[Evaluation of tumor necrosis factor-alpha and tumor necrosis factor-beta in serum of patients with endometriosis].
OBJECTIVE
To evaluate the levels of tumor necrosis factor-alpha (TNF-alpha) and tumor necrosis factor-beta (TNF-beta) before and after conservative laparoscopic surgery in patients with endometriosis.


METHODS
The levels of TNF-alpha and TNF-beta in the serum of both 82 patients with EMS and 68 controls were determined by ELISA.


RESULTS
The levels of TNF-alpha and TNF-beta in the serum of patients with EMS were significantly higher than those of the controls (P < 0.01), and they increased with the clinical terms ( P < 0.05). After clearance of endometrosis foci with laparoscopic conservative surgery, the TNF-alpha levels decreased significantly in EMS III - IV, and TNF-beta levels decreased significantly in EMS I - IV.


CONCLUSIONS
Measuring TNF-alpha and TNF-beta levels in the serum of patients with EMS may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of the surgery.
Luo
Min
M
Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
He
Yuan-Li
YL
Peng
Dong-Xian
DX
Liu
Mu-Biao
MB
Chen
Yan-Ying
YY
D000293:Adolescent; D000328:Adult; D004715:Endometriosis / Q000097:blood* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D008233:Lymphotoxin-alpha / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha