title: Clonal granulocytes in polycythaemia vera and essential thrombocythaemia have shortened telomeres.
abstract: Summary The purpose of this study was to evaluate telomere length in peripheral blood granulocytes and mononuclear cells collected from 22 women with polycythaemia vera (PV) and essential thrombocythaemia (ET). PV and ET are chronic myeloproliferative diseases whose heterogeneity of stem cell origin and clonal development has been established through analysis of X-chromosome inactivation patterns. The results from clonality assay and determination of telomere length show that only clonal granulocytes have shortened telomeres.
authors.affiliation: Ematologia Oncologica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. annamaria.ferraris@istge.it
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ferraris
authors.forename: Natalija
authors.initials: N
authors.lastname: Pujic
authors.forename: Rosa
authors.initials: R
authors.lastname: Mangerini
authors.forename: Davide
authors.initials: D
authors.lastname: Rapezzi
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallamini
authors.forename: Omar
authors.initials: O
authors.lastname: Racchi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Casciaro
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Gaetani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002999:Clone Cells; D005260:Female; D006098:Granulocytes / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000648:ultrastructure; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007963:Leukocytes, Mononuclear / Q000648:ultrastructure; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000276:immunology*; D016615:Telomere / Q000648:ultrastructure*; D013920:Thrombocythemia, Essential / Q000150:complications / Q000276:immunology*