Role of mitochondria in the mechanisms of glutamate toxicity.
Current data on glutamate-induced functional and morphological changes in mitochondria correlating with or being a result of their membrane potential changes are reviewed. The important role of Ca2+, Na+, and H+ in the potentiation of such changes is considered. It is assumed that glutamate-induced loss of mitochondrial potential is mediated by Ca2+ overload resulting in the induction of nonspecific permeability of the inner mitochondrial membrane.
Isaev
N K
NK
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia. isaev@genebee.msu.su
Andreeva
N A
NA
Stel'mashuk
E V
EV
Zorov
D B
DB
D002118:Calcium / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D018846:Excitatory Amino Acids / Q000502:physiology*; D018698:Glutamic Acid / Q000633:toxicity*; D006706:Homeostasis; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010539:Permeability; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism
D018846:Excitatory Amino Acids; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D002118:Calcium