title: Cholesterol embolization treated with corticosteroids--two case reports.
abstract: Cholesterol embolization (CE) is a potentially serious complication associated with invasive arterial maneuvers, in which standard therapy has not been established. We experienced two cases of CE in patients with severe atherosclerosis whose renal function deteriorated within a few months after invasive arterial maneuvers. CE was confirmed either by renal biopsy (case 1) or skin biopsy (case 2). Oral administration of prednisolone at a daily dose of 30 mg (0.4 mg/kg) was effective to improve their renal function. Our observation suggests that corticosteroid therapy may be beneficial in some patients with CE.
authors.affiliation: Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Koga
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ohno
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Okamoto
authors.forename: Kazuta
authors.initials: K
authors.lastname: Nakasuga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Nagafuji
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shimono
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Koga
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hayashida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Arita
authors.forename: Toru
authors.initials: T
authors.lastname: Maruyama
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kaji
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology; D006328:Cardiac Catheterization / Q000009:adverse effects; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D017700:Embolism, Cholesterol / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone; D003404:Creatinine