Evaluation of the developmental toxicity of 8-2 telomer B alcohol.
The potential maternal and developmental toxicity of 8-2 Telomer B Alcohol was assessed in rats. Groups of 22 time-mated female Crl:CD (SD)IGS BR rats were administered oral gavage doses as suspensions of 8-2 Telomer B Alcohol in aqueous 0.5% methylcellulose from day 6 through 20 of gestation (G) at daily doses of either 0, 50, 200, or 500 mg/kg. Under the conditions of this study, adverse maternal toxicity was produced at 500 mg kg(- 1) day(- 1) and consisted of maternal mortality, decreased body weights and body weight gains, and increased clinical observations of toxicity. One litter at 500 mg kg(- 1) day(- 1) consisted of one early resorption and was believed to be secondary to overt maternal toxicity, although single conceptus litters occur historically in this strain of rats. Developmental toxicity at 500 mg kg(- 1) day(- 1) consisted of increased fetal skeletal variations (delayed pelvic bone ossification and wavy ribs). At 200 and 500 mg kg(- 1) day(- 1), there were transient reductions in maternal feed consumption. In addition, there were slight increases in the incidence of delayed fetal skull bone ossification at 200 and 500 mg kg(- 1) day(- 1). The no-observed-adverse-effect level (NOAEL), defined as the highest dose at which adverse effects attributable to the test substance were not detected, for both maternal and developmental toxicity, is considered to be 200 mg kg(- 1) day(- 1). Thus, 8-2 Telomer B Alcohol is not considered to be a selective developmental toxicant in rats. The transient and quantitative nature of the observations in the 200 mg/kg group supports the conclusion that these findings were not adverse.
Mylchreest
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DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19711, USA.
Munley
S M
SM
Kennedy
G L
GL
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005233:Fatty Alcohols / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000473:pathology; D005327:Fetal Resorption / Q000139:chemically induced; D005865:Gestational Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D051381:Rats; D012744:Sex Ratio; D013723:Teratogens; D015430:Weight Gain / Q000187:drug effects; D005466:Fluorocarbons
D005233:Fatty Alcohols; D013723:Teratogens; C505284:1,1,2,2-tetrahydroheptadecafluorodecanol-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol; D005466:Fluorocarbons