title: First nosocomial outbreak of Pseudomonas aeruginosa producing an integron-borne metallo-beta-lactamase (VIM-2) in the United States.
abstract: Carbapenemases are rare in the United States. This is the first report of a United States nosocomial outbreak of pan-resistant Pseudomonas aeruginosa infections due to an integron-borne metallo-beta-lactamase, VIM-2. This emergence of carbapenemases on mobile genetic elements in the United States warrants surveillance.
authors.affiliation: John H. Stroger, Jr. Hospital, Rush University, Chicago, Illinois 60612, USA.
authors.forename: K
authors.initials: K
authors.lastname: Lolans
authors.forename: A M
authors.initials: AM
authors.lastname: Queenan
authors.forename: K
authors.initials: K
authors.lastname: Bush
authors.forename: A
authors.initials: A
authors.lastname: Sahud
authors.forename: J P
authors.initials: JP
authors.lastname: Quinn
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D006801:Humans; D032023:Integrons; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D017422:Sequence Analysis, DNA; D014481:United States / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases