Allele-specific genotyping by using guanine and gold electrochemical oxidation signals.
Electrochemical DNA biosensors have become strong candidates for DNA based analysis. Allele-specific genotyping is also one of the important research areas, where electrochemical approaches provide promising advances. Recently reported two methods based on electrochemical guanine and colloidal gold (Au) nanoparticle oxidation signals are reviewed and compared with the existing genotyping methods in this report.
Ozsoz
Mehmet
M
Ege University, Faculty of Pharmacy, Analytical Chemistry Department, 35100 Bornova, Izmir, Turkey. ozsozs@pharm.ege.edu.tr
Erdem
Arzum
A
Ozkan
Dilsat
D
Kara
Pinar
P
Karadeniz
Hakan
H
Meric
Burcu
B
Kerman
Kagan
K
Girousi
Stella
S
D000483:Alleles; D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods*; D004563:Electrochemistry / Q000379:methods*; D005838:Genotype; D006046:Gold / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D009154:Mutation; D049329:Nanostructures / Q000737:chemistry; D010084:Oxidation-Reduction
D006147:Guanine; D006046:Gold; D004247:DNA