title: Comparison of the antiinflammatory effects of Drosera rotundifolia and Drosera madagascariensis in the HET-CAM assay.
abstract: The antiinflammatory effects of ethanol and aqueous extracts from Drosera rotundifolia and from Drosera madagascariensis were compared in vivo in the HET-CAM assay. Both extracts from D. rotundifolia and the ethanol extract from D. madagascariensis showed remarkable efficacy at doses of 500 microg/pellet. The inhibition of the inflammation by the extracts was stronger than that by 50 microg hydrocortisone/pellet. In contrast, there was only a very weak effect observed at a dose of 500 microg/pellet of the water extract from D. madagascariensis. The chemical analyses of the extracts showed that the effect cannot be attributed to naphthoquinones, but might be due to flavonoids. Ellagic acid obviously plays an important role in the antiangiogenic effect of the Drosera extracts.
authors.affiliation: Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Universität Regensburg, D-93040 Regensburg, Germany.
authors.forename: Dietrich H
authors.initials: DH
authors.lastname: Paper
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Karall
authors.forename: Michaela
authors.initials: M
authors.lastname: Kremser
authors.forename: Liselotte
authors.initials: L
authors.lastname: Krenn
mesh_terms: D000482:Allantois / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001681:Biological Assay; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D029787:Drosera; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts