title: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps.
abstract: The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.
authors.affiliation: Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA. wmurphy@cvm.tamu.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Murphy
authors.forename: Denis M
authors.initials: DM
authors.lastname: Larkin
authors.forename: Annelie
authors.initials: A
authors.lastname: Everts-van der Wind
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bourque
authors.forename: Glenn
authors.initials: G
authors.lastname: Tesler
authors.forename: Loretta
authors.initials: L
authors.lastname: Auvil
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Beever
authors.forename: Bhanu P
authors.initials: BP
authors.lastname: Chowdhary
authors.forename: Francis
authors.initials: F
authors.lastname: Galibert
authors.forename: Lisa
authors.initials: L
authors.lastname: Gatzke
authors.forename: Christophe
authors.initials: C
authors.lastname: Hitte
authors.forename: Stacey N
authors.initials: SN
authors.lastname: Meyers
authors.forename: Denis
authors.initials: D
authors.lastname: Milan
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
authors.forename: Greg
authors.initials: G
authors.lastname: Pape
authors.forename: Heidi G
authors.initials: HG
authors.lastname: Parker
authors.forename: Terje
authors.initials: T
authors.lastname: Raudsepp
authors.forename: Margarita B
authors.initials: MB
authors.lastname: Rogatcheva
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Schook
authors.forename: Loren C
authors.initials: LC
authors.lastname: Skow
authors.forename: Michael
authors.initials: M
authors.lastname: Welge
authors.forename: James E
authors.initials: JE
authors.lastname: Womack
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'brien
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Pevzner
authors.forename: Harris A
authors.initials: HA
authors.lastname: Lewin
mesh_terms: D000818:Animals; D002415:Cats / Q000235:genetics; D002417:Cattle / Q000235:genetics; D002503:Centromere / Q000235:genetics; D043171:Chromosomal Instability; D002869:Chromosome Aberrations; D019457:Chromosome Breakage; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics; D033481:Chromosomes, Mammalian / Q000235:genetics*; D019295:Computational Biology; D004285:Dogs / Q000235:genetics; D019143:Evolution, Molecular; D016678:Genome; D015894:Genome, Human; D006736:Horses / Q000235:genetics; D006801:Humans; D008322:Mammals / Q000235:genetics*; D051379:Mice / Q000235:genetics; D009369:Neoplasms / Q000235:genetics; D051381:Rats / Q000235:genetics; D013552:Swine / Q000235:genetics; D026801:Synteny; D016615:Telomere / Q000235:genetics