title: Decoding Tat: the biology of HIV Tat posttranslational modifications.
abstract: The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.
authors.affiliation: Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hetzer
authors.forename: Wilma
authors.initials: W
authors.lastname: Dormeyer
authors.forename: Martina
authors.initials: M
authors.lastname: Schnölzer
authors.forename: Melanie
authors.initials: M
authors.lastname: Ott
mesh_terms: D001120:Arginine / Q000378:metabolism; D015696:Gene Products, tat / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus; D001120:Arginine