title: Improving 1-year outcome in first-episode psychosis: OPUS trial.
abstract: BACKGROUND
  Because early illness course and outcome may affect the long-term outcome of schizophrenia-spectrum disorders, it is especially important to address poor outcome in this early critical period.
  
  
  OBJECTIVE
  To evaluate whether integrated treatment compared with standard treatment reduced the proportion of patients with poor clinical and social outcome after 1 year.
  
  
  METHODS
  A total of 547 patients with first-episode psychosis were included in the study, 275 randomly assigned to integrated treatment and 272 to standard treatment. Measures assessed psychotic symptoms and social functioning.
  
  
  RESULTS
  There was a significant beneficial effect of integrated treatment v. standard treatment on "any poor outcome". Integrated treatment had a significantly better effect on "any poor outcome" in patients with schizophrenia compared with patients in standard treatment.
  
  
  CONCLUSIONS
  The integrated treatment significantly reduced the proportion of patients with poor clinical and social outcome compared with standard treatment.
authors.affiliation: Department of Psychiatry, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. lonepetersen@mail.dk
authors.forename: Lone
authors.initials: L
authors.lastname: Petersen
authors.forename: Merete
authors.initials: M
authors.lastname: Nordentoft
authors.forename: Pia
authors.initials: P
authors.lastname: Jeppesen
authors.forename: Johan
authors.initials: J
authors.lastname: Ohlenschaeger
authors.forename: Anne
authors.initials: A
authors.lastname: Thorup
authors.forename: Torben Østergaard
authors.initials: TØ
authors.lastname: Christensen
authors.forename: Gertrud
authors.initials: G
authors.lastname: Krarup
authors.forename: Jytte
authors.initials: J
authors.lastname: Dahlstrøm
authors.forename: Bodil
authors.initials: B
authors.lastname: Haastrup
authors.forename: Per
authors.initials: P
authors.lastname: Jørgensen
mesh_terms: D000293:Adolescent; D000328:Adult; D019033:Delivery of Health Care, Integrated / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011618:Psychotic Disorders / Q000628:therapy*; D012917:Social Adjustment; D017211:Treatment Failure