Dendrimeric micelles for controlled drug release and targeted delivery.
This review highlights the developments in dendrimer-based micelles for drug delivery. Dendrimers, the perfectly branched monodisperse macromolecules, have certain structural advantages that make them attractive candidates as drug carriers for controlled release or targeted delivery. As polymeric micelle-based approaches precede the work in dendrimers, these are also discussed briefly. The review concludes with a perspective on possible applications of biaryl-based dendrimeric micelles that exhibit environment-dependent conformations, in drug delivery.
Ambade
Ashootosh V
AV
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Savariar
Elamprakash N
EN
Thayumanavan
S
S
D000666:Amphotericin B / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D046911:Macromolecular Substances; D008823:Micelles; D015394:Molecular Structure; D011073:Polyamines; D011092:Polyethylene Glycols
D004337:Drug Carriers; D046911:Macromolecular Substances; D008823:Micelles; D011073:Polyamines; D011092:Polyethylene Glycols; D000666:Amphotericin B