title: Pneumonectomy for unilateral destroyed lung with pulmonary hypertension due to systemic blood flow through broncho-pulmonary shunts.
abstract: OBJECTIVE
  Three decades ago, a few patients with pulmonary hypertension and respiratory failure associated with a unilateral destroyed lung were reported to have been treated by a pneumonectomy. In the present study, we investigated the clinical features, operative indications, and results of four cases with pulmonary hypertension that underwent a pneumonectomy for a unilateral destroyed lung.
  
  
  METHODS
  Four patients (three males, one female) with a destroyed lung and pulmonary hypertension (mean pulmonary arterial pressure >25 mmHg) were treated by a pneumonectomy between 1999 and 2002 at our institution. Their mean age was 59 years old (range 42-68 years). The underlying lung disease, Medical Research Council (MRC) dyspnea scale, respiratory function, arterial blood gas analysis, pulmonary arterial pressure, preoperative management, operative procedure, and postoperative course for each were reviewed retrospectively.
  
  
  RESULTS
  The underlying lung disease that caused the destroyed lung was bronchiectasis in two patients, chronic empyema with bronchopleural fistula in one, and necrotizing pneumonia in one. The average mean pulmonary artery pressure was 33 mmHg (range 25-42 mmHg), which decreased to 27 mmHg (range 19-36 mmHg) after occlusion of the pulmonary artery in the affected lung. Following the pneumonectomy, the average mean pulmonary artery pressure was decreased to 17 mmHg (range 11-25 mmHg). Chronic inflammatory symptoms and functional impairments (showed by blood gas analysis, pulmonary arterial pressure, or MRC dyspnea scale) improved post-pneumonectomy. There was no operative death, though postoperative cardiorespiratory failure occurred in one patient. All patients were discharged from the hospital.
  
  
  CONCLUSIONS
  We concluded that a pneumonectomy procedure may be indicated for selected patients with a unilateral destroyed lung and pulmonary hypertension due to systemic blood flow though broncho-pulmonary shunts.
authors.affiliation: Department of Surgery, National Hospital Organization Kinki-chuo Chest Medical Center, 1180 Nagasonechou Sakai city, Osaka 591-8555, Japan. h-tanaka@kch.hosp.go.ch
authors.forename: Hisaichi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Akihide
authors.initials: A
authors.lastname: Matsumura
authors.forename: Meinoshin
authors.initials: M
authors.lastname: Okumura
authors.forename: Keiji
authors.initials: K
authors.lastname: Iuchi
mesh_terms: D000328:Adult; D000368:Aged; D001983:Bronchial Fistula / Q000150:complications / Q000601:surgery; D001987:Bronchiectasis / Q000150:complications / Q000601:surgery; D004653:Empyema / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology* / Q000601:surgery*; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010995:Pleural Diseases / Q000150:complications / Q000601:surgery; D011013:Pneumonectomy / Q000379:methods*; D011014:Pneumonia / Q000150:complications / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome