title: Auxin transport.
abstract: Polar transport of auxin is essential for normal plant growth and development. On a cellular level, directional auxin transport is primarily controlled by an efflux carrier complex that is characterized by the PIN-FORMED (PIN) family of proteins. Detailed developmental studies of PIN distribution and subcellular localization have been combined with the analysis of changes in localized auxin levels to map PIN-mediated auxin movement throughout Arabidopsis tissues. Plant orthologs of mammalian multidrug-resistance/P-glycoproteins (MDR/PGPs) also function in auxin efflux. MDR/PGPs appear to stabilize efflux complexes on the plasma membrane and to function as ATP-dependent auxin transporters, with the specificity and directionality of transport being provided by interacting PIN proteins.
authors.affiliation: Department of Horticulture, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Blakeslee
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Peer
authors.forename: Angus S
authors.initials: AS
authors.lastname: Murphy
mesh_terms: D001692:Biological Transport; D002352:Carrier Proteins / Q000502:physiology; D007210:Indoleacetic Acids / Q000378:metabolism*; D008954:Models, Biological; D063245:Plant Development; D010940:Plant Proteins / Q000502:physiology; D010944:Plants / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D007210:Indoleacetic Acids; D010940:Plant Proteins