title: [Renal aging].
abstract: Frequently underestimated, the deterioration of the renal function characteristic of the aging has very prominent clinical consequences. In the present article some aspects of the cellular and molecular biology of this process are analysed. The critical role of the oxidative stress and of TGFbeta are underlined. Determinant genetic factors are also mentioned. Such a knowledge can contribute to develop therapeutical strategies to prevent the decline of the.renal function that happens with the aging.
authors.affiliation: Sección de Nefrología y Unidad de Investigación, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Madrid.
authors.forename: G
authors.initials: G
authors.lastname: Pérez Rivero
authors.forename: M P
authors.initials: MP
authors.lastname: Torres Ruiz
authors.forename: I
authors.initials: I
authors.lastname: Serrano
authors.forename: H
authors.initials: H
authors.lastname: Bouarich
authors.forename: D
authors.initials: D
authors.lastname: Rodríguez Puyol
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D015152:Blotting, Northern; D005109:Extracellular Matrix / Q000378:metabolism; D005609:Free Radicals; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D007672:Kidney Cortex / Q000378:metabolism / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D013482:Superoxide Dismutase