title: [Expressions of survivin and nm23 and the relationship among the expressions and the axillary lymph node metastasis in breast cancer].
abstract: OBJECTIVE
  To investigate the expressions of Survivin protein and nm23 protein and the relationship among the expressions and axillary lymph node metastasis in breast cancer.
  
  
  METHODS
  The expression of Survivin and nm23 in 80 cases of breast cancer tissues were detected by immunohistochemistry SP method, and their correlation with axillary lymph node metastasis and 5-year disease free survival (DFS) were analysed.
  
  
  RESULTS
  Survivin protein positive expression rate was 68.75% (55/80) in breast cancer tissues, which had positive correlation with the axillary lymph nodes metastasis but negative correlation with 5 years FS (P < 0.05); nm23 protein expression had negative correlation with the axillary lymph nodes metastasis but positive to 5 years FS (P < 0.05). Survivin and nm23 proteins expression had no obvious correlation with the breast cancer pathology type, patient age and clinical stage (P > 0.05).
  
  
  CONCLUSIONS
  The anti-apoptosis effect of Survivin protein and the anti-metastasis effect of nm23 protein may be important in the occurrence and advancement of breast cancer, suggesting that it may be a new indicator of prognostic and judgement in breast cancer.
authors.affiliation: Department of Breast Surgery, Xiangya Hospital of Central South University, Changsha, Hunan. maojie1166@sina.com
authors.forename: Jie
authors.initials: J
authors.lastname: Mao
authors.forename: Jian
authors.initials: J
authors.lastname: Hai
authors.forename: Heng-Ping
authors.initials: HP
authors.lastname: Shu
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Wu
authors.forename: Hui-Yin
authors.initials: HY
authors.lastname: Ou
authors.forename: Sha-Yang
authors.initials: SY
authors.lastname: Luo
authors.forename: Shou-Man
authors.initials: SM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D012189:Retrospective Studies; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins; D000077022:Survivin; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase