title: Are those phospholipids in your pocket?
abstract: The identification of phospholipids ligands for the nuclear receptors SF-1 and LRH-1 raise exciting new questions in the areas of signaling and metabolism. Do these receptors provide cells with a mechanism to alter genomic activities in response to phospholipid flux? The tools now exist to address these questions, and more.
authors.affiliation: Gene Regulation and Drug Discovery, The Beckman Research Institute at The City of Hope National Medical Center, Gonda Diabetes Research Center, 1500 East Duarte Road, Duarte, California 91010, USA.
authors.forename: Barry Marc
authors.initials: BM
authors.lastname: Forman
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins; D006801:Humans; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology*; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C082631:NR5A2 protein, human; D010743:Phospholipids; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors