[Molecular mechanism of diabetic retinopathy: role of advanced glycation end products(AGEs) and their receptor (RAGE) in the pathogenesis of diabetic retinopathy].
There is a growing body of evidence that advanced glycation end product-receptor(AGE-RAGE) interaction elicits oxidative stress generation, thus indicating that it is involved in the pathogenesis of diabetic retinopathy. Inhibition of AGE formation or blockade of the downstream RAGE signaling is a promising therapeutic strategy for treatment of patients with diabetic retinopathy.
Yamagishi
Sho-ichi
S
Department of Internal Medicine III, Kurume University School of Medicine, Japan.
Imaizumi
Tsutomu
T
D000818:Animals; D017209:Apoptosis; D003930:Diabetic Retinopathy / Q000209:etiology* / Q000628:therapy; D042783:Endothelial Cells; D011464:Epoprostenol / Q000096:biosynthesis; D005136:Eye Proteins / Q000502:physiology; D017127:Glycation End Products, Advanced / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000166:cytology; D009389:Neovascularization, Pathologic; D009414:Nerve Growth Factors / Q000502:physiology; D018384:Oxidative Stress; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology; D012170:Retinal Vein Occlusion / Q000209:etiology; D012171:Retinal Vessels / Q000166:cytology; D015843:Serpins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D000099174:Pigment Epithelium-Derived Factor
D011464:Epoprostenol; D005136:Eye Proteins; D017127:Glycation End Products, Advanced; D009414:Nerve Growth Factors; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D015843:Serpins; D042461:Vascular Endothelial Growth Factor A; D000099174:Pigment Epithelium-Derived Factor