title: Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.
abstract: Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds.
authors.affiliation: Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Pontillo
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Guo
authors.forename: Dongpei
authors.initials: D
authors.lastname: Wu
authors.forename: R Scott
authors.initials: RS
authors.lastname: Struthers
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
mesh_terms: D006801:Humans; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D011485:Protein Binding; D011966:Receptors, LHRH / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D007659:Ketones; D011966:Receptors, LHRH; D014227:Triazines