Immunogenicity and immunological memory induced by a 7-valent pneumococcal CRM197 conjugate vaccine in symptomatic HIV-1 infected children.
A 7-valent CRM197 conjugate pneumococcal vaccine (PCV)-induced immune response were evaluated in all Greek symptomatic HIV-1 infected children and 21 age-matched controls. PCV immunogenicity was inferior in HIV patients compared with the controls although differences in geometric mean concentrations (GMC) were not significant (P>.05). Immune responses were strikingly different after anamnestic immunization, given in all study subjects, 12 months later. HIV-positive children achieved lower GMC for all serotypes compared with the controls (P=.002) and avidity for all except serotype 6B was inferior compared to baseline. Long-term PCV effectiveness is expected to be reduced among symptomatic HIV-1 infected children.
Spoulou
Vana I
VI
1st Department of Pediatrics, Division of Infectious Diseases, Aghia Sophia Children's Hospital, Athens University School of Medicine, Thivon and M. Asias St., Goudi 11527, Athens, Greece. vspoulou@cc.uoa.gr
Tsoumas
Dimitris L
DL
Papaevangelou
Vana G
VG
Mostrou
Glykeria I
GI
Theodoridou
Maria C
MC
D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis; D000915:Antibody Affinity; D002648:Child; D005260:Female; D006115:Greece; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D007156:Immunologic Memory / Q000276:immunology*; D007700:Kinetics; D008297:Male; D022242:Pneumococcal Vaccines / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate