[Expression and significance of cyclin D1 in human adenoid cystic carcinoma].
OBJECTIVE
To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clinical characters.


METHODS
The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue.


RESULTS
The expression of cyclin D1 in normal tissue was negative, significantly different from PA and ACC (P < 0.05). The expression level of PA was significantly lower than ACC (P < 0.05). High expression of cyclin D1 was correlated with clinical stage and histological classification (P < 0.05), but not with sex, age, tumor site, recurrence, metastasis.


CONCLUSIONS
High expression of cyclin D1 promotes the formation and development of ACC.
He
Wei
W
Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China.
Cao
Xuan-Ping
XP
Li
Long-Jiang
LJ
D002277:Carcinoma; D003528:Carcinoma, Adenoid Cystic; D019938:Cyclin D1; D005260:Female; D006801:Humans; D008875:Middle Aged; D012468:Salivary Gland Neoplasms
D019938:Cyclin D1