Umbilical cord blood-derived cells for tissue repair.
Hematopoietic tissue-derived cells, including stem cells, have been shown to generate solid organ tissue-specific cells. Besides bone marrow and peripheral blood, umbilical cord blood (UCB) has the advantage of being an easily accessible stem cell source provided as a banked cell product. Using the xenogeneic human into NOD/SCID mouse stem cell transplant model preliminary data suggest UCB-derived tissue-specific cells generated in liver, pancreas, CNS and endothelium. In a clinical sex-mismatched UCB transplant setting Y-positive, UCB-derived gastrointestinal epithelial cells and CNS-specific cells have been identified in female patients. The potential therapeutic use of UCB cells for tissue repair is, however, limited by a low total stem cell number available and by HLA-disparity.
Körbling
M
M
Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Robinson
S
S
Estrov
Z
Z
Champlin
R
R
Shpall
E
E
D000818:Animals; D002454:Cell Differentiation; D002493:Central Nervous System Diseases / Q000628:therapy; D036101:Cord Blood Stem Cell Transplantation; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D004847:Epithelial Cells / Q000166:cytology; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology / Q000637:transplantation; D041981:Gastrointestinal Tract / Q000166:cytology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008107:Liver Diseases / Q000628:therapy