title: Genes that mediate breast cancer metastasis to lung.
abstract: By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.
authors.affiliation: Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: Andy J
authors.initials: AJ
authors.lastname: Minn
authors.forename: Gaorav P
authors.initials: GP
authors.lastname: Gupta
authors.forename: Peter M
authors.initials: PM
authors.lastname: Siegel
authors.forename: Paula D
authors.initials: PD
authors.lastname: Bos
authors.forename: Weiping
authors.initials: W
authors.lastname: Shu
authors.forename: Dilip D
authors.initials: DD
authors.lastname: Giri
authors.forename: Agnes
authors.initials: A
authors.lastname: Viale
authors.forename: Adam B
authors.initials: AB
authors.lastname: Olshen
authors.forename: William L
authors.initials: WL
authors.lastname: Gerald
authors.forename: Joan
authors.initials: J
authors.lastname: Massagué
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D045744:Cell Line, Tumor; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D009362:Neoplasm Metastasis / Q000235:genetics*; D012334:RNA, Neoplasm / Q000032:analysis / Q000235:genetics; D015203:Reproducibility of Results; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: D012334:RNA, Neoplasm