Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients.
Using quantitative autoradiography, the present study examined ionotropic glutamatergic receptor binding sites using [3H]dizocilpine, [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate, and [3H]kainate in the posterior cingulate cortex of schizophrenia patients and matched controls. We found a significant increase in [3H]dizocilpine binding in the superficial layers (41%, p<0.001) and deep layers (30%, p=0.004) of the posterior cingulate cortex in the schizophrenia group compared with controls. No significant differences were observed in [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and [3H]kainate binding. In summary, the present study has for the first time demonstrated that the glutamatergic system is affected in the posterior cingulate cortex in schizophrenia patients. The fact that only the N-methyl-D-aspartate receptor densities are significantly altered suggests that this is unlikely to be caused by a simple decrease in glutamatergic transmission.
Newell
Kelly A
KA
Neuroscience Institute of Schizophrenia and Allied Disorders, University of Wollongong, New South Wales, Australia.
Zavitsanou
Katerina
K
Huang
Xu-Feng
XF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001345:Autoradiography / Q000379:methods; D016022:Case-Control Studies; D003710:Demography; D016291:Dizocilpine Maleate / Q000493:pharmacokinetics; D018690:Excitatory Amino Acid Agonists / Q000493:pharmacokinetics; D018691:Excitatory Amino Acid Antagonists / Q000493:pharmacokinetics; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007608:Kainic Acid / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D011485:Protein Binding / Q000187:drug effects; D017470:Receptors, Glutamate / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D014316:Tritium / Q000493:pharmacokinetics; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000493:pharmacokinetics
D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D017470:Receptors, Glutamate; D014316:Tritium; D016291:Dizocilpine Maleate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid