The role of cavitation in acoustically activated drug delivery.
Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.
Husseini
Ghaleb A
GA
Department of Chemical Engineering, Brigham Young University, Provo, Utah 84602, USA.
Diaz de la Rosa
Mario A
MA
Richardson
Eric S
ES
Christensen
Douglas A
DA
Pitt
William G
WG
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008823:Micelles; D020442:Poloxamer; D013050:Spectrometry, Fluorescence; D014465:Ultrasonics
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008823:Micelles; D020442:Poloxamer; D004317:Doxorubicin