Simple surface modification of poly(epsilon-caprolactone) to induce its apatite-forming ability.
A biodegradable polymer coated with a bone-like apatite layer on its surface is useful as a scaffold for bone tissue regeneration. In this work, a poly(epsilon-caprolactone) (PCL) surface was modified by an O2 plasma surface treatment to form oxygen-containing functional groups. The plasma-treated samples were subsequently dipped alternately in an alcoholic solution containing calcium ions and one containing phosphate ions to deposit apatite precursors on the surface. The surface-modified PCL samples formed a dense and uniform surface bone-like apatite layer after immersion for 24 h in a simulated body fluid with ion concentrations approximately equal to those of human blood plasma. This surface-modification process is applicable to two-dimensional PCL plates and three-dimensional PCL meshes. In the resulting apatite-PCL composite, the apatite layer strongly adhered to the PCL surface and remained intact after a tape-detachment test. Therefore, this type of composite material will be a useful scaffold for bone tissue engineering.
Oyane
Ayako
A
Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan. a-oyane@aist.go.jp
Uchida
Masaki
M
Yokoyama
Yoshiro
Y
Choong
Cleo
C
Triffitt
James
J
Ito
Atsuo
A
D020341:Absorbable Implants; D000438:Alcohols / Q000737:chemistry; D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D021621:Imaging, Three-Dimensional; D007477:Ions; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D012038:Regeneration; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D013499:Surface Properties; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods; D014961:X-Ray Diffraction
D000438:Alcohols; D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D007477:Ions; D010710:Phosphates; D011091:Polyesters; C016240:polycaprolactone; D010100:Oxygen; D002118:Calcium