title: Thermal behaviour and stability in Olanzapine.
abstract: The stability and thermal behaviour of two anhydrate phases and a new mixed water:DMSO solvate of Olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine) are studied by different methods: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and Raman scattering (RS). Single crystal structural data for the latter phase are presented, confirming the presence of the (Olanzapine)(2) dimer as the structural building unit of all known phases of the drug, either anhydrate or solvated. An apparent interconversion between both solid state forms is shown to be an artifact and explained in terms of a melting-recrystallization process.
authors.affiliation: Unidad de Actividad Física, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, San Martín, 1650 Buenos Aires, Argentina.
authors.forename: Griselda I
authors.initials: GI
authors.lastname: Polla
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Vega
authors.forename: Hilda
authors.initials: H
authors.lastname: Lanza
authors.forename: Dora G
authors.initials: DG
authors.lastname: Tombari
authors.forename: Ricardo
authors.initials: R
authors.lastname: Baggio
authors.forename: Alejandro Pedro
authors.initials: AP
authors.lastname: Ayala
authors.forename: Josué Mendes
authors.initials: JM
authors.lastname: Filho
authors.forename: Daniel
authors.initials: D
authors.lastname: Fernández
authors.forename: Gabriela
authors.initials: G
authors.lastname: Leyva
authors.forename: Gustavo
authors.initials: G
authors.lastname: Dartayet
mesh_terms: D014150:Antipsychotic Agents / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D004121:Dimethyl Sulfoxide; D004355:Drug Stability; D006358:Hot Temperature; D008958:Models, Molecular; D000077152:Olanzapine; D012997:Solvents; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D014150:Antipsychotic Agents; D012997:Solvents; D001569:Benzodiazepines; D000077152:Olanzapine; D004121:Dimethyl Sulfoxide