[Hearing screening in infants with congenital cytomegalovirus infection].
To investigate the impact of congenital cytomegalovirus infection on the hearing ability in infants.



By using the tools of distortion product otoacoustic emission (DPOAE) and auditory brain-stem response (ABR), the hearing ability of 38 infants with congenital cytomegalovirus infection and 16 cases of normal controls during neonatal periods was screened with a follow-up study at 6 and 24 months.



In infants with congenital cytomegalovirus infection, 86.8% (66/76) ears at neonatal stage and 76.3% (58/76) ears at 6 months passed the tests; while in normal controls, 96.9% (31/32) ears passed the tests. The reaction threshold of ABR V in infants with congenital cytomegalovirus infection was higher than that in normal controls (P<0.005). Furthermore,in infants with congenital cytomegalovirus infection, 13 ears (17.1%) were extreme hearing loss, 5 ears (6.6%) were severe hearing loss, and 6 ears (7.9%) were moderately severe hearing loss. The incidence of hearing loss during the follow-up was 7.9% (3/38) at neonatal stage, 23.7% (9/38) at 3-4 months, and 7.9% (3/38) after 6 months.



The congenital cytomegalovirus infection could cause the prompt and late-onset hearing loss. The combination of the laboratory evidence with the dynamic hearing screening may contribute to the early detection of hearing loss in infants with congenital cytomegalovirus infection.
Mo
Wei
W
The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. mowei@yahoo.com.cn
Zhang
Yi-ying
YY
Lei
Yun-qiu
YQ
Sun
Wei
W
Shao
Pei-fen
PF
Sun
Yue-feng
YF
Zhou
Yuan-yuan
YY
Zhao
Zheng-yan
ZY
D002681:China / Q000453:epidemiology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005500:Follow-Up Studies; D006312:Hearing Loss, Bilateral / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D017084:Otoacoustic Emissions, Spontaneous