Targeting malaria parasite proteins to the erythrocyte.
The intraerythrocytic stages of the protozoan parasite Plasmodium falciparum reside within a parasitophorous vacuole (PV) and set up unique "extraparasite, intraerythrocyte" protein-trafficking pathways that target parasite-encoded proteins to the erythrocyte cytoplasm and cell surface. Two recent articles report the identification of trafficking motifs that regulate the transport of parasite-encoded proteins across the PV. These articles greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the erythrocyte cytoplasm or cell membrane.
Templeton
Thomas J
TJ
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA. tjt2001@med.cornell.edu
Deitsch
Kirk W
KW
D000595:Amino Acid Sequence; D000818:Animals; D004912:Erythrocytes / Q000469:parasitology* / Q000648:ultrastructure; D017125:Genes, Protozoan; D006790:Host-Parasite Interactions; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D015800:Protozoan Proteins / Q000378:metabolism*; D016415:Sequence Alignment; D014617:Vacuoles / Q000469:parasitology*
D015800:Protozoan Proteins