A new synthesis of isoaurones: cytotoxic activity of compounds related to the alleged structure of isoaurostatin.
A new synthesis of isoaurones related to the alleged structure of isoaurostatin, via Heck intramolecular cyclization of cinnamic esters of 2-iodophenols, is reported. The cytotoxic activity of these isoaurones is lower than that of the structurally very similar 4-arylcoumarins.
Rizzi
Eleonora
E
Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, I 20133 Milano, Italy.
Dallavalle
Sabrina
S
Merlini
Lucio
L
Beretta
Giovanni Luca
GL
Pratesi
Graziella
G
Zunino
Franco
F
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002289:Carcinoma, Non-Small-Cell Lung; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003500:Cyclization; D004952:Esters; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001572:Benzofurans; D004952:Esters; C486837:aurone; C433579:isoaurostatin