Lipid carrier systems for targeted drug and gene delivery.
For effective chemotherapy, it is necessary to deliver therapeutic agents selectively to their target sites, since most drugs are associated with both beneficial effects and side effects. The use of lipid dispersion carrier systems, such as lipid emulsions and liposomes, as carriers of lipophilic drugs has attracted particular interest. A drug delivery system can be defined as a methodology for manipulating drug distribution in the body. Since drug distribution depends on the carrier, administration route, particle size of the carrier, lipid composition of the carrier, electric charge of the carrier and ligand density of the targeting carrier, these factors must be optimized. Recently, the lipid carrier system has also been applied to gene delivery systems for gene therapy. However, in both drug and gene medicine cases, a lack of cell-selectivity limits the wide application of this kind of drug and/or gene therapy. Therefore, lipid carrier systems for targeted drug and gene delivery must be developed for the rational therapy. In this review, we shall focus on the progress of research into lipid carrier systems for drug and gene delivery following systemic or local injection.
Hashida
Mitsuru
M
Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. hashidam@pharm.kyoto-u.ac.jp
Kawakami
Shigeru
S
Yamashita
Fumiyoshi
F
D004337:Drug Carriers; D004655:Emulsions; D015870:Gene Expression; D018014:Gene Transfer Techniques; D015552:Injections, Intralesional; D008055:Lipids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010316:Particle Size
D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids