Labeling studies on the formation pathway of Nepsilon-carboxymethyllysine in maillard-type reactions.
Nepsilon-carboxymethyllysine (CML) is among the most often studied advanced glycation end products (AGEs) in foods and medicine, and several pathways have been suggested for its formation. Based on the results of model studies using glucose labeled with carbon-13 in different positions, a new pathway is proposed for CML formation without involving free glyoxal or autoxidation reactions.
Kasper
Martina
M
Department of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, D-85748 Garching, Germany.
Schieberle
Peter
P
D002247:Carbon Isotopes; D017127:Glycation End Products, Advanced; D008239:Lysine / Q000031:analogs & derivatives* / Q000737:chemistry; D015416:Maillard Reaction; D008958:Models, Molecular
D002247:Carbon Isotopes; D017127:Glycation End Products, Advanced; C048496:N(6)-carboxymethyllysine; D008239:Lysine