title: Nasal and bronchial response to exercise in patients with asthma and rhinitis: the role of nitric oxide.
abstract: BACKGROUND
  Physical exercise is associated with a decrease in nasal resistance in rhinitis and an increase in bronchial resistance in asthma. The objective was to evaluate the relationship between the levels of nasal nitric oxide (nNO) and exhaled bronchial nitric oxide (eNO) with bronchial responses to exercise in patients with rhinitis and asthma.
  
  
  METHODS
  We submitted 24 subjects with asthma and rhinitis to an exercise test. A decrease in FEV(1)> or =15% was considered positive. The volume of the nasal cavity and the minimal cross-sectional area (MCA) was evaluated by means of acoustic rhinometry (AR), and nNO and eNO were evaluated by chemoluminiscence. The measurements were recorded at baseline, 15 and 50 min after the end of the exercise test.
  
  
  RESULTS
  The exercise test was positive in 17 cases. Fifteen minutes after exercise test, the nasal volume increased by 57% (P < 0.0001) and was still increased by 30% after 50 min (P < 0.0001). There was no correlation between decrease in FEV(1) and increase in nasal volume. The baseline value of nNO was 1185 +/- 439 ppb, and the value at 15 and 50 min was 1165 +/- 413 and 1020 +/- 368 ppb, the latter value being significantly lower (P < 0.01) than the baseline. The baseline value of eNO was 21 +/- 19 ppb, with no significant differences at 15 and 50 min. There was no significant correlation between either the decrease in FEV(1) and the nasal response, or the baseline eNO and nNO values.
  
  
  CONCLUSIONS
  The nasal and bronchial response to exercise is completely different in rhinitis and asthma; in the former, an increase in nasal volume occurs, while in the latter there is a drop in FEV(1). There is no relationship between the values of nasal or exhaled NO and the nasal and bronchial response after exercise.
authors.affiliation: Unidad de Alergia, Servicio de Neumología y Alerdia Respiratoria, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Valero
authors.forename: C
authors.initials: C
authors.lastname: Serrano
authors.forename: J L
authors.initials: JL
authors.lastname: Valera
authors.forename: A
authors.initials: A
authors.lastname: Barberá
authors.forename: A
authors.initials: A
authors.lastname: Torrego
authors.forename: J
authors.initials: J
authors.lastname: Mullol
authors.forename: C
authors.initials: C
authors.lastname: Picado
mesh_terms: D000328:Adult; D001249:Asthma / Q000378:metabolism / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000503:physiopathology; D001980:Bronchi / Q000737:chemistry; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000737:chemistry; D015508:Nasal Obstruction / Q000503:physiopathology; D009569:Nitric Oxide / Q000032:analysis* / Q000378:metabolism; D012220:Rhinitis / Q000378:metabolism / Q000503:physiopathology*; D023842:Rhinometry, Acoustic
chemical_list: D009569:Nitric Oxide