Transforming growth factor-beta: importance in long-term peritoneal membrane changes.
We have provided evidence from adenovirus-mediated gene transfer to the peritoneum that transforming growth factor-beta1 mimics many of the functional and structural changes in the peritoneum in patients on long-term peritoneal dialysis, including fibrosis, increased submesothelial thickness, angiogenesis, increased solute transport, and ultrafiltration dysfunction. We review several key properties of this important fibrogenic molecule.
Margetts
Peter J
PJ
Department of Medicine, McMaster University, Hamilton, Ontario, Canada. margetts@mcmaster.ca
Oh
Kook-Hwan
KH
Kolb
Martin
M
D006801:Humans; D010532:Peritoneal Diseases / Q000209:etiology; D010537:Peritoneum / Q000187:drug effects* / Q000293:injuries; D016212:Transforming Growth Factor beta / Q000009:adverse effects / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1