Cord blood transplantation in adult patients.
Early clinical reports outlining outcomes for primarily pediatric patients undergoing UCB transplantation point to delayed time to hematopoietic recovery and favorable incidence and severity of GvHD. Recently, clinical reports in adult patients identified the feasibility of UCB transplantation for those patients lacking an available histocompatible-related or unrelated adult donor Intensive clinical and laboratory research is ongoing focused on strategies to foster UCB allogeneic donor engraftment thereby allowing wider application of this stem cell source for patients requiring allogeneic transplantation.
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Medicine and Pathology, Case Western Reserve University, University Hospitals Comprehensive Cancer Center, Cleveland, Ohio, USA.
Laughlin
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D000328:Adult; D001771:Blood Banks; D036101:Cord Blood Stem Cell Transplantation; D005312:Fetal Blood / Q000276:immunology; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D014184:Transplantation, Homologous