Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice.
Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.
da Silva
Marcelo Aparecido
MA
Departamento de Química Orgânica, Instituto de Química, c.p. 355, CEP 14800-900, UNESP, Araraquara, SP, Brazil.
Rafacho
Bruna Paola Murino
BP
Hiruma-Lima
Clelia Akiko
CA
da Rocha
Lúcia Regina Machado
LR
dos Santos
Lourdes Campaner
LC
Sannomiya
Miriam
M
Souza-Brito
Alba Regina Monteiro
AR
Vilegas
Wagner
W
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D031451:Strychnos / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts