Acylphloroglucinol derivatives from Mahurea palustris.
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 microM range.
Massiot
Georges
G
Joint Service Unit No. 2597, National Center for Scientific Research (CNRS)-Pierre Fabre, Sciences and Technologies Institute of Medicine of Toulouse, 31432 Toulouse, France. georges.massiot@pierre-fabre.com
Long
Christophe
C
David
Bruno
B
Serrano
Marie-Jeanne
MJ
Daubié
Florence
F
Alby
Frédéric
F
Ausseil
Frédéric
F
Knibiehler
Martine
M
Moretti
Christian
C
Hoffmann
Jean-Sébastien
JS
Cazaux
Christophe
C
Lavaud
Catherine
C
D028084:Clusiaceae / Q000737:chemistry*; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005616:French Guiana; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D004791:Enzyme Inhibitors; D010696:Phloroglucinol; D019951:DNA Polymerase beta