title: Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola.
abstract: From the antibacterial fraction of the roots of Garcinia kola, 3'',4',4''',5,5'',7,7''-heptahydroxy-3,8''-biflavanone (GB1) was isolated as the major constituent, whose interesting conformations were studied on the basis of its 1D and 2D NMR spectra obtained at different temperatures and in different solvents. GB1 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) with MIC of 32 and 128 microg/ml, respectively.
authors.affiliation: Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Song-Fong
authors.initials: SF
authors.lastname: Lee
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Zhen-Dan
authors.initials: ZD
authors.lastname: He
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D044946:Biflavonoids / Q000737:chemistry* / Q000494:pharmacology; D029763:Garcinia kola / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D044946:Biflavonoids