Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study.
Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies.
Linnebank
M
M
Department of Neurology, University Hospital Bonn, Bonn, Germany. michael.linnebank@ukb.uni-bonn.de
Montenarh
M
M
Kölsch
H
H
Linnebank
A
A
Schnez
K
K
Schweichel
D
D
Pohl
C
C
Urbach
H
H
Heun
R
R
Harbrecht
U
U
Klockgether
T
T
Wüllner
U
U
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006710:Homocysteine / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D012333:RNA, Messenger / Q000096:biosynthesis; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D020521:Stroke / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)