title: Ceftazidime in acute myeloid leukemia patients with febrile neutropenia: helpfulness of continuous intravenous infusion in maximizing pharmacodynamic exposure.
abstract: The pharmacokinetic-pharmacodynamic profile of a fixed 6-g daily continuous intravenous infusion of ceftazidime was assessed in 20 febrile neutropenic patients with acute myeloid leukemia. Mean steady-state ceftazidime concentrations averaging 40 mg/liter from day 2 on ensured maximized pharmacodynamic exposure (values close to four to five times the MIC breakpoint against Pseudomonas aeruginosa). However, large intra- and interindividual pharmacokinetic variability was documented throughout the study period.
authors.affiliation: Institute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, P. le S. Maria della Misericordia 3, 33100 Udine, Italy. federico.pea@med.uniud.it
authors.forename: Federico
authors.initials: F
authors.lastname: Pea
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
authors.forename: Daniela
authors.initials: D
authors.lastname: Damiani
authors.forename: Federica
authors.initials: F
authors.lastname: Pavan
authors.forename: Francesco
authors.initials: F
authors.lastname: Cristini
authors.forename: Renato
authors.initials: R
authors.lastname: Fanin
authors.forename: Mario
authors.initials: M
authors.lastname: Furlanut
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D002442:Ceftazidime / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007262:Infusions, Intravenous; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009503:Neutropenia / Q000150:complications / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002442:Ceftazidime