title: Impact of hypertension and apolipoprotein E4 on poststroke cognition in subjects >75 years of age.
abstract: OBJECTIVE
  The apolipoprotein E4 allele (APOE4) associates with increased dementia risk, and hypertension may associate with mild cognitive deficits. We examined whether nondemented stroke patients with (1) a prestroke history of hypertension and (2) APOE4 were more cognitively impaired at 3 months after stroke.
  
  
  METHODS
  A total of 257 participants were genotyped and outcomes from neuropsychological evaluations analyzed using regression.
  
  
  RESULTS
  Total Cambridge Assessment for Mental Disorders in the Elderly (CAMCOG) and speed of working memory significantly associated with hypertension. No outcomes significantly associated with APOE4.
  
  
  CONCLUSIONS
  Subjects with prestroke hypertension had more impaired global cognition and slower access to information held in working memory.
authors.affiliation: Institute for Aging and Health, University of Newcastle upon Tyne, UK. e.n.rowan@ncl.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Rowan
authors.forename: C M
authors.initials: CM
authors.lastname: Morris
authors.forename: S
authors.initials: S
authors.lastname: Stephens
authors.forename: C
authors.initials: C
authors.lastname: Ballard
authors.forename: H
authors.initials: H
authors.lastname: Dickinson
authors.forename: H
authors.initials: H
authors.lastname: Rao
authors.forename: B K
authors.initials: BK
authors.lastname: Saxby
authors.forename: A T
authors.initials: AT
authors.lastname: McLaren
authors.forename: R N
authors.initials: RN
authors.lastname: Kalaria
authors.forename: R A
authors.initials: RA
authors.lastname: Kenny
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001281:Atrial Fibrillation / Q000235:genetics; D003071:Cognition; D003072:Cognition Disorders / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012737:Sex Factors; D020521:Stroke / Q000235:genetics* / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E