Synthesis, spectra and biomimetic properties of copper(II)-copper(II) and copper(II)-zinc(II) binuclear complexes with CuN5 chromophores.
X-band electron spin resonance (ESR) and UV-vis spectra of a homobinuclear [(Bipy)2Cu-E-Im-Cu(Bipy)2](BF4)3 and a heterobinuclear [(Bipy)2Cu-E-Im-Zn(Bipy)2](BF4)3 complexes, E-Im=2-ethylimidazolate ion have been described as possible models for superoxide dismutase (SOD). Magnetic moment and ESR spectral measurements of the homobinuclear complex have shown an antiferromagnetic exchange interaction. From pH-dependent ESR and UV-vis spectral measurements studies, these complexes have been found to be stable over 8.5-10.5 pH range. These complexes catalyze the dismutation of superoxide (O2-) at biological pH. All the observations indicate that these complexes act as good possible models for superoxide dismutase.
Patel
R N
RN
Department of Chemistry, A.P.S. University, Rewa 486003, India. rnp64@yahoo.co.uk
Singh
Nripendra
N
Shukla
K K
KK
Gundla
V L N
VL
Chauhan
U K
UK
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003116:Color; D003300:Copper / Q000737:chemistry*; D004121:Dimethyl Sulfoxide; D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011514:Proteus vulgaris / Q000187:drug effects; D012996:Solutions / Q000737:chemistry; D013053:Spectrophotometry; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism; D015032:Zinc / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D012996:Solutions; D013481:Superoxides; D003300:Copper; D013482:Superoxide Dismutase; D015032:Zinc; D004121:Dimethyl Sulfoxide