title: Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.
abstract: The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These results suggest that the neuroprotective effect of the KD on the KA-induced toxicity may be, in part, mediated via an increased expression of CB.
authors.affiliation: Department of Anatomy and Neurobiology, Institute of Health Science, College of Medicine, Gyeongsang National University, 92 Chilam-dong, Chinju, Kyungnam 660-751, Republic of Korea.
authors.forename: Hae Sook
authors.initials: HS
authors.lastname: Noh
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Park
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Han
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
mesh_terms: D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D005526:Food, Formulated; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D007608:Kainic Acid; D007657:Ketone Bodies / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
chemical_list: C576499:Calb1 protein, mouse; D064092:Calbindin 1; D064026:Calbindins; D007657:Ketone Bodies; D064030:S100 Calcium Binding Protein G; D007608:Kainic Acid