title: Severe transfusion-related acute lung injury.
abstract: A 46-yr-old man developed severe hypoxemia, pulmonary infiltrates, and an acute decrease in his leukocyte count shortly after transfusion of fresh-frozen plasma (FFP) during recovery from cardiac surgery. Cardiogenic pulmonary edema was excluded. Granulocyte-reactive and agglutinating alloantibodies were detected in the serum of the fresh-frozen plasma donor. The cross-match with the patient's granulocytes revealed antibodies specific for HLA class I. Transfusion-related acute lung injury (TRALI) is a potentially life-threatening, under-recognized and under-reported complication of transfusion. Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and could save lives.
  
  
  CONCLUSIONS
  Transfusion-related acute lung injury (TRALI) is a potentially life-threatening, probably under-recognized and under-reported complication of transfusing blood products. Conservative transfusion strategies and preclusion of the implicated blood donors with granulocyte-reactive antibodies from future blood donation may prevent TRALI and potentially save lives.
authors.affiliation: *Department of Intensive Care Medicine and †Department of Hematology and Central Hematology Laboratory, Division of Transfusion Medicine, University Hospital-Inselspital, Bern, Switzerland; and ‡Blood Transfusion Service, SRC Bern Ltd., Bern, Switzerland.
authors.forename: Lukas
authors.initials: L
authors.lastname: Brander
authors.forename: Angelika
authors.initials: A
authors.lastname: Reil
authors.forename: Juergen
authors.initials: J
authors.lastname: Bux
authors.forename: Behrouz Mansouri
authors.initials: BM
authors.lastname: Taleghani
authors.forename: Bruno
authors.initials: B
authors.lastname: Regli
authors.forename: Jukka
authors.initials: J
authors.lastname: Takala
mesh_terms: D000208:Acute Disease; D000918:Antibody Specificity; D001772:Blood Cell Count; D006348:Cardiac Surgical Procedures; D006098:Granulocytes / Q000276:immunology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000276:immunology; D011859:Radiography; D065227:Transfusion Reaction
chemical_list: D007518:Isoantibodies