[Effects of Guanyu capsule on the behavior and cerebral cortex monoamine neurotransmitters in depressive model of olfactory bulb damage rats].
OBJECTIVE
To investigate the behavioral changes and the levels of monoamine neurotransmitters in the anterior cortex in the olfactory bulb damage rats after being treated with Guanyu capsules (GYC).


METHODS
Open-field test and step-down passive avoidance test were used to observe the behavior in model rats. HPLC-ECD was used to analyze the influences of GYC on the levels of monoamine neurotransmitters.


RESULTS
In the model rats, there was a characteristic hyperactivity in the Open-field and learning deficits in step-down passive avoidance (P < 0.01). The contents of 5-HT reduced, and the rate of DOPAC/DA increased significantly (P < 0.01). GYC 1.2, 0.6 g x kg(-1) could correct behavioral changes increase the contents of 5-HT, and decrease DOPAC/DA level (P < 0.01).


CONCLUSIONS
GYC can correct behavioral changes in rats model of olfactory bulb damage, and regulating 5-HT and DA metabolism in cortex is one of the antidepressive mechanisms of GYC.
Wang
Jing-xia
JX
Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
Zhang
Jian-jun
JJ
Zhong
Gan-sheng
GS
Zhang
De-qin
DQ
Hu
Su-min
SM
Li
Wei
W
Ou
Li-na
LN
Gao
Xue-min
XM
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D030024:Curcuma / Q000737:chemistry; D003863:Depression / Q000209:etiology / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D032492:Dryopteris / Q000737:chemistry; D008297:Male; D009830:Olfactory Bulb / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism
D015306:Biogenic Monoamines; D004365:Drugs, Chinese Herbal; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D004298:Dopamine