Pregnancy in patients with previous successful renal transplantation.
OBJECTIVE
To evaluate the risk factors affecting pregnancy, perinatal outcomes, and short-term graft condition in women who underwent renal transplantation.


METHODS
Between May 1998 and January 2005, the histories of 20 pregnancies in 17 renal transplant recipients were reviewed retrospectively at the Ministry of Health Aegean Obstetrics and Gynecology Teaching Hospital.


RESULTS
There were significant associations between high serum creatinine level (>1.5 mg/dL) prior to pregnancy and preterm delivery (P=0.04), and between short interval between transplantation and pregnancy (<2 years) and increased rate of cesarean sections (P=0.04). There were no significant changes in serum creatinine levels during pregnancy in these women, and there were no acute rejection and graft loss during pregnancy or in the 6 months following delivery.


CONCLUSIONS
These findings suggest that, although pregnancy does not adversely affect short-term renal allograft function, the rates of obstetric and perinatal complications are increased. Risk factors present before conception are a short interval between renal transplantation and pregnancy and poor renal function.
Yildirim
Y
Y
Ministry of Health Aegean Obstetrics and Gynecology Teaching Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey. Ykuzeyli@mynet.com
Uslu
A
A
D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
D003404:Creatinine