title: Increased human immunodeficiency virus type 1 (HIV-1) env compartmentalization in the presence of HIV-1-associated dementia.
abstract: The human immunodeficiency virus type 1 (HIV-1) surface Env protein has been implicated in the development of HIV-1-associated dementia (HAD). HIV-1 env diversity was analyzed by heteroduplex tracking assay in 27 infected subjects with various neurological statuses. env compartmentalization between the blood and cerebral spinal fluid (CSF) was apparent with all neurological categories. However, in subjects with HAD, significantly more CSF virus was represented by CNS-unique env variants. Variants specialized for replication in the CNS may play a larger role in the development of HAD. Alternatively, HAD may be associated with a more pronounced state of immunosuppression that permits more extensive replication and independent evolution within the CNS compartment.
authors.affiliation: University of North Carolina at Chapel Hill, UNC Center for AIDS Research, Chapel Hill, NC 27599-7295, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Ritola
authors.forename: Kevin
authors.initials: K
authors.lastname: Robertson
authors.forename: Susan A
authors.initials: SA
authors.lastname: Fiscus
authors.forename: Colin
authors.initials: C
authors.lastname: Hall
authors.forename: Ronald
authors.initials: R
authors.lastname: Swanstrom
mesh_terms: D015526:AIDS Dementia Complex / Q000209:etiology / Q000821:virology*; D000328:Adult; D000595:Amino Acid Sequence; D001921:Brain / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D015686:Gene Products, env / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D014779:Virus Replication
chemical_list: D015686:Gene Products, env