title: Long-term (56-week) oral administration of probiotic Enterococcus faecium M-74 decreases the expression of sICAM-1 and monocyte CD54, and increases that of lymphocyte CD49d in humans.
abstract: OBJECTIVE
  To study the effects of long-term probiotic [Enterococcus faecium (EF) M-74 strain] application in humans with respect to adhesion molecules, both soluble forms (sICAM-1, sPECAM-1) and their expression on leukocytes.
  
  
  METHODS
  Double-blinded randomized and placebo controlled study lasting for 60 weeks. A single capsule containing either 2x10(9) of bacteria EF M-74 with 50 microg of organically bound selenium (E-group) or placebo (P-group) was given to volunteers. Peripheral blood was analyzed for the expression of particular adhesive molecules.
  
  
  CONCLUSIONS
  We observed significant changes in CAMs expression in terms of a decrease in sICAM-1, CD54 on monocytes and CD11b on lymphocytes after one-year administration of Enterococcus faecium M-74 in humans. Anti-adhesion-aimed therapeutic modalities may provide the future approach to prevention and treatment of cardiovascular diseases. Application of probiotics may be part of such strategies. (Tab. 2, Fig. 6, Ref. 41.)
authors.affiliation: Department of Arrhythmias, Slovak Institute of Cardiovascular Diseases, Bratislava, Slovakia. hlivak@susch.sk
authors.forename: P
authors.initials: P
authors.lastname: Hlivak
authors.forename: E
authors.initials: E
authors.lastname: Jahnova
authors.forename: J
authors.initials: J
authors.lastname: Odraska
authors.forename: M
authors.initials: M
authors.lastname: Ferencik
authors.forename: L
authors.initials: L
authors.lastname: Ebringer
authors.forename: Z
authors.initials: Z
authors.lastname: Mikes
mesh_terms: D000284:Administration, Oral; D000368:Aged; D004311:Double-Blind Method; D016984:Enterococcus faecium; D005260:Female; D006801:Humans; D039441:Integrin alpha4 / Q000096:biosynthesis*; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis; D019936:Probiotics / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D039441:Integrin alpha4