title: Infiltrative trichilemmal carcinoma treated with 5% imiquimod cream.
abstract: BACKGROUND
  Trichilemmal carcinoma (TLC) is a rare cutaneous neoplasm that occurs in the sun-exposed skin of the elderly. Although the clinical behavior of TLC appears to be relatively indolent, wide excision or Mohs micrographic surgery is the recommended treatment owing to its locally aggressive growth. Recently, imiquimod has become an important part of the armamentarium in the treatment of nonmelanoma skin cancer.
  
  
  OBJECTIVE
  This article serves to remind dermatologists that in addition to Mohs micrographic surgery and surgical excision, imiquimod 5% cream may have a role in the treatment of TLC.
  
  
  METHODS
  In addition to a review of the literature, we present a case of TLC successfully treated with 5% imiquimod cream.
  
  
  CONCLUSIONS
  Its nonsurgical approach and excellent cosmetic result make imiquimod 5% cream another promising therapeutic option for TLC, even though it is histologically infiltrative.
authors.affiliation: Department of Dermatology, College of Medicine, Pusan National University, Busan, Korea.
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jo
authors.forename: Hyun-Chang
authors.initials: HC
authors.lastname: Ko
authors.forename: Ho-Sun
authors.initials: HS
authors.lastname: Jang
authors.forename: Moon-Bum
authors.initials: MB
authors.lastname: Kim
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Oh
authors.forename: Kyung-Sool
authors.initials: KS
authors.lastname: Kwon
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D005145:Face / Q000473:pathology; D005260:Female; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D000077271:Imiquimod; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod