A recurring theme in protein engineering: the design, stability and folding of repeat proteins.
Repeat proteins are ubiquitous and are involved in a myriad of essential processes. They are typically non-globular structures that act as diverse scaffolds for the mediation of protein-protein interactions. These excitingly different structures, which arise from tandem arrays of a repeated structural motif, have generated significant interest with respect to protein engineering and design. Recent advances have been made in the design and characterisation of repeat proteins. The highlights include re-engineering of binding specificity, quantitative models of repeat protein stability and kinetic studies of repeat protein folding.
Main
Ewan R G
ER
Cambridge University Chemical Laboratory, Cambridge University, Lensfield Road, Cambridge CB2 1EW, UK.
Lowe
Alan R
AR
Mochrie
Simon G J
SG
Jackson
Sophie E
SE
Regan
Lynne
L
D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D015202:Protein Engineering; D017510:Protein Folding