Synthesis, characterization, and antitumoral activity of polyoxometalate loaded starch nanocomplexes.
Using a reverse-phase microemulsion polymerization method and an encapsulating method, polyoxometalates (POMs) K6SiW11TiO40 incorporating starch microspheres have been prepared and structurally characterized by elemental analyses, IR, UV-vis, and NMR spectroscopy. The size of SiW11TiO40/starch particles is about 40-60 nm. The polyoxometalate encapsulated by a starch microsphere retains the parent structure. The starch microsphere is a good carrier, as it is able to enhance the antitumoral activity of POMs and decrease the toxicity of POMs as well.
Wang
Xiaohong
X
Faculty of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Xu
Linlin
L
Li
Yingwei
Y
Li
Feng
F
D000970:Antineoplastic Agents / Q000008:administration & dosage; D002470:Cell Survival / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000737:chemistry; D004058:Diffusion; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry*; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D008422:Materials Testing; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013213:Starch / Q000737:chemistry*; D017973:Tungsten Compounds / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry*
D000970:Antineoplastic Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D017973:Tungsten Compounds; D013213:Starch