title: Early detection and intervention in psychosis: an ethical paradigm shift.
abstract: This paper will first posit the rationale for intervention before onset, then outline the current usual practice of treating schizophrenia and the determinants of that practice. Recent developments that permit or demand a change in this practice will then be elaborated. The article concludes with an elaboration of the currently known risks and benefits of early intervention research. The ethics of early intervention are undergoing a paradigm shift, a shift that supports early intervention research as being necessary to bring empirical balance to territory that is currently overpopulated with zealous opinions.
authors.affiliation: Yale Psychiatric Research, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06519, USA. Thomas.mcglashan@yale.edu
authors.forename: Thomas H
authors.initials: TH
authors.lastname: McGlashan
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D042241:Early Diagnosis; D004992:Ethics, Medical; D006801:Humans; D008605:Mental Health Services / Q000941:ethics / Q000639:trends*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000628:therapy*; D018570:Risk Assessment; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents