Plasma ropivacaine levels during awake intracranial surgery.
Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.
Audu
Paul B
PB
Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. paul.audu@jefferson.edu
Wilkerson
Chuck
C
Bartkowski
Richard
R
Gingrich
Kevin
K
Viscusi
Eugene
E
Andrews
David
D
D000328:Adult; D000368:Aged; D000577:Amides / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010865:Pilot Projects; D000077212:Ropivacaine; D012535:Scalp; D014851:Wakefulness
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine