title: Comparison of acellular pertussis vaccines-induced immunity against infection due to Bordetella pertussis variant isolates in a mouse model.
abstract: A significant increase in the incidence of pertussis in adolescents and adults has been observed in vaccinated populations. Concomitantly, emergence of novel pertussis toxin and pertactin types in circulating Bordetella pertussis isolates was noticed. In this study, immunity induced by acellular vaccines against infection due to isolates expressing different pertactin types and fimbriae was monitored in a mouse model. In accordance with previous studies, the effect of a bicomponent DTPa vaccine on bacterial clearance was lower when compared with tri- or pentavalent DTPa vaccines. Whatever the isolates used to infect mice, the tri- or pentavalent DTPa vaccines were both efficacious in inducing immunity that resulted in clearance of infection. These findings suggest that re-emergence of pertussis might not be related to emergence of isolates escaping vaccine protection. The present study reduces potential concerns about acellular vaccine efficacy, but frequent monitoring of protection and surveillance of the evolution of the B. pertussis population remains of particular importance.
authors.affiliation: Research & Development, GlaxoSmithKline Biologicals, Rue de l'Institut 89, 1330 Rixensart, Belgium. philippe.denoel@gskbio.com
authors.forename: Philippe
authors.initials: P
authors.lastname: Denoël
authors.forename: Fabrice
authors.initials: F
authors.lastname: Godfroid
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
authors.forename: Hans
authors.initials: H
authors.lastname: Hallander
authors.forename: Jan
authors.initials: J
authors.lastname: Poolman
mesh_terms: D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008168:Lung / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010567:Pertussis Vaccine / Q000737:chemistry / Q000276:immunology*; D015203:Reproducibility of Results; D013045:Species Specificity; D022282:Vaccines, Acellular / Q000737:chemistry / Q000276:immunology; D014917:Whooping Cough / Q000382:microbiology* / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine; D022282:Vaccines, Acellular