title: Insulin-like growth factor-I (IGF-1) mRNA levels and chicken muscle growth.
abstract: Insulin-like Growth Factor-1 is a key regulator of muscle development and metabolism in birds and other vertebrate species. In a first part, the present paper sums up the specificities of the IGF system in birds and especially those related to muscle development. In a second part, it reviews available data obtained with avian genetic or nutritional models. Data obtained by comparing genetic models with large variations of overall body growth show a positive relation between endocrine IGF-1 and growth rate. Data obtained using both genetic and nutritional models show a positive relation between muscle IGF-1 mRNA levels, which determine paracrine IGF-1 levels, and post hatch muscle growth.
authors.affiliation: Station de Recherches Avicoles, INRA, 37380, Nouzilly, France. duclos@tours.inra.fr
authors.forename: M J
authors.initials: MJ
authors.lastname: Duclos
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D001823:Body Composition; D002645:Chickens / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D004435:Eating; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D023421:Models, Animal; D024510:Muscle Development / Q000235:genetics; D009132:Muscles / Q000378:metabolism*; D009154:Mutation; D009752:Nutritional Status; D019899:Paracrine Communication; D012333:RNA, Messenger / Q000378:metabolism*; D013045:Species Specificity; D015430:Weight Gain
chemical_list: D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I