Antineoplastic effects of butanolic residue of Pfaffia paniculata.
We have previously reported a reduction in the accumulation of ascitic fluid in Ehrlich tumor-bearing mice following treatment with the powdered roots of Pfaffia paniculata. The aim of this study was to investigate which extracts from these roots presented antineoplastic properties. Thus, the effects of the ethanolic extract, butanolic residue, or aqueous residue from Pfaffia paniculata on animal survival and tumor growth in mice bearing this tumor were studied. Butanolic residue-treated mice survived longer than untreated mice. This result points to an antineoplastic effect exerted by the butanolic fraction from the roots of P. paniculata on this tumor model.
Matsuzaki
Patrícia
P
Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, CEP 05508-900, São Paulo-SP, Brazil.
Haraguchi
Mitsue
M
Akisue
Gokithi
G
Oloris
Sílvia Catarina Salgado
SC
Nagamine
Márcia Kazumi
MK
da Silva
Tereza Cristina
TC
Sakai
Monica
M
de Souza Monteiro Fonseca
Evelise
E
Palermo-Neto
João
J
Górniak
Silvana Lima
SL
Dagli
Maria Lúcia Zaidan
ML
D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000627:therapeutic use*; D000440:Butanols / Q000737:chemistry*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D000431:Ethanol / Q000737:chemistry; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D015996:Survival Rate; D014867:Water / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D000440:Butanols; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol