title: Acute painful neuropathy in thallium poisoning.
abstract: Dysesthesia, allodynia, distal muscle weakness, and sensory impairment were noted in two patients with acute thallium intoxication. Two months later, nerve conduction studies showed an axonal degeneration. Sural nerve biopsy disclosed a decreased fiber density in the large myelinated fibers. Quantitative sensory testing also revealed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy confirmed a loss of epidermal nerves indicating an involvement of the small sensory nerves.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan.
authors.forename: H-C
authors.initials: HC
authors.lastname: Kuo
authors.forename: C-C
authors.initials: CC
authors.lastname: Huang
authors.forename: Y-T
authors.initials: YT
authors.lastname: Tsai
authors.forename: C-C
authors.initials: CC
authors.lastname: Chu
authors.forename: S-T
authors.initials: ST
authors.lastname: Hsieh
authors.forename: N-S
authors.initials: NS
authors.lastname: Chu
mesh_terms: D000208:Acute Disease; D001706:Biopsy; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects / Q000473:pathology; D018908:Muscle Weakness / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects / Q000473:pathology; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009437:Neuralgia / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D009475:Neurons, Afferent / Q000187:drug effects / Q000473:pathology; D009619:Nociceptors / Q000187:drug effects / Q000473:pathology; D010525:Peripheral Nerves / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D020886:Somatosensory Disorders / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D013497:Sural Nerve / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D013793:Thallium / Q000506:poisoning*
chemical_list: D013793:Thallium