Synthesis and cytotoxicity of novel sansalvamide A derivatives.
Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in the cytotoxicity, and they lay the groundwork for development of new anticancer agents. [structure: see text]
Carroll
Chris L
CL
Department of Chemistry, Molecular Biology Institute, and Center for Applied and Experimental Genomics, 5500 Campanile Road, 208 CSL, San Diego State University, San Diego, CA 92182-1030, USA.
Johnston
Jennifer V C
JV
Kekec
Ahmet
A
Brown
Joseph D
JD
Parry
Emily
E
Cajica
Julia
J
Medina
Irene
I
Cook
Kristina M
KM
Corral
Ricardo
R
Pan
Po-Shen
PS
McAlpine
Shelli R
SR
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D047630:Depsipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D047630:Depsipeptides; C119376:sansalvamide A