title: [Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men].
abstract: OBJECTIVE
  To identify single nucleotide polymorphisms (SNP) of the angiotensin II type 2 receptor (AGTR2) gene, and to determine whether the AGTR2 polymorphisms are associated with essential hypertension in a male Chinese population.
  
  
  METHODS
  Direct DNA sequencing was performed in 20 subjects. 96 male hypertensive patients and 107 normal controls were included to assess the contribution of the SNP of AGTR2 gene to hypertension.
  
  
  RESULTS
  Seven SNP of the AGTR2 gene were identified, of which 4 were reported for the first time. A case-control study including two polymorphisms (A1675G and T1334C) showed a significant increase in the A1675 allele frequency among male hypertensive subjects as compared with normotensive subjects (49.0% vs 34.6%, P < 0.05).
  
  
  CONCLUSIONS
  The AGTR2 A1675G polymorphism might be involved in the development of essential hypertension in male Chinese.
authors.affiliation: Shandong Provincial Hospital, Clinical Medical College of Shandong University, Jinan 250021, China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Qiao
authors.forename: Kui-xing
authors.initials: KX
authors.lastname: Zhang
authors.forename: Tong-bao
authors.initials: TB
authors.lastname: Liu
authors.forename: Guo-xiang
authors.initials: GX
authors.lastname: Liu
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Xu
mesh_terms: D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*
chemical_list: D044139:Receptor, Angiotensin, Type 2