Clonal granulocytes in polycythaemia vera and essential thrombocythaemia have shortened telomeres.
Summary The purpose of this study was to evaluate telomere length in peripheral blood granulocytes and mononuclear cells collected from 22 women with polycythaemia vera (PV) and essential thrombocythaemia (ET). PV and ET are chronic myeloproliferative diseases whose heterogeneity of stem cell origin and clonal development has been established through analysis of X-chromosome inactivation patterns. The results from clonality assay and determination of telomere length show that only clonal granulocytes have shortened telomeres.
Ferraris
Anna Maria
AM
Ematologia Oncologica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. annamaria.ferraris@istge.it
Pujic
Natalija
N
Mangerini
Rosa
R
Rapezzi
Davide
D
Gallamini
Andrea
A
Racchi
Omar
O
Casciaro
Salvatore
S
Gaetani
Gian Franco
GF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002999:Clone Cells; D005260:Female; D006098:Granulocytes / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000648:ultrastructure; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007963:Leukocytes, Mononuclear / Q000648:ultrastructure; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000276:immunology*; D016615:Telomere / Q000648:ultrastructure*; D013920:Thrombocythemia, Essential / Q000150:complications / Q000276:immunology*