title: Association of malignant disease with critical leg ischaemia.
abstract: BACKGROUND
  The aim of the study was to determine the prevalence of malignant disease in patients with critical leg ischaemia (CLI).
  
  
  METHODS
  : Data for all patients with CLI presenting to a tertiary vascular unit over an 18-month interval were collected prospectively. Patients with clinical, laboratory or radiological features suggestive of malignancy were evaluated further.
  
  
  RESULTS
  Of 192 patients admitted with CLI, 22 (11.5 per cent) were found to have an associated malignancy; ten had lung cancer. Fifteen were anaemic on presentation. The prevalence of occult malignancy in patients with acute leg ischaemia was 16 per cent (ten of 62) compared with 9.2 per cent (12 of 130) in those with chronic CLI. Eleven of 22 of patients with CLI and malignancy died within 6 months, compared with 35 (20.6 per cent) of 170 patients with no evidence of malignancy.
  
  
  CONCLUSIONS
  A high prevalence of occult cancer was found in patients presenting with CLI; this was associated with a significantly increased mortality rate at 6 months.
authors.affiliation: Department of Vascular Surgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
authors.forename: K
authors.initials: K
authors.lastname: El Sakka
authors.forename: R P S
authors.initials: RP
authors.lastname: Gambhir
authors.forename: M
authors.initials: M
authors.lastname: Halawa
authors.forename: P
authors.initials: P
authors.lastname: Chong
authors.forename: H
authors.initials: H
authors.lastname: Rashid
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D011446:Prospective Studies