[Study on chemical constituents in rhizome of Pinellia ternata].
OBJECTIVE
To study the chemical constituents in rhizome of Pinellia ternata.


METHODS
The constituents were isolated by silica-gel and Sephadex LH-20 chromatography. The structures were identified by spectroscopic analysis including 2D NMR techniques.


RESULTS
Six compounds were obtained and identified as stigmast-4-en-3-one(I), cycloartenol(II), 5alpha,8alpha-epidioxyergosta-6,22-dien-3-ol(III), beta-sitosterol-3-O-beta-D-glucoside-6'-eicosanate(IV), alpha-monpalmitin(V), beta-sitosterol(VI). The bioactive assay indicated that: compound III was active against the human tumor cell lines HCT-8, Bel-7402, BGC-823, A549, A2780.


CONCLUSIONS
Compounds I-IV were isolated from Pinellia ternata for the first time, compound II was the first triterpene isolated from this genus. Compound III may be one of the antitumor constituents of P. ternata.
He
Ping
P
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Li
Shuai
S
Wang
Su-juan
SJ
Yang
Yong-chun
YC
Shi
Jian-gong
JG
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification*; D030021:Pinellia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D013265:Stigmasterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes
C503471:5alpha,8alpha-epidioxyergosta-6,22-dien-3-beta-ol; D000972:Antineoplastic Agents, Phytogenic; D010840:Phytosterols; D014315:Triterpenes; C488470:stigmast-4-en-3-one; D013265:Stigmasterol; C100089:cycloartenol; D004875:Ergosterol