title: Androgens and prostate cancer: are the descriptors valid?
abstract: The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (AI)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.
authors.forename: Pradip
authors.initials: P
authors.lastname: Roy-Burman
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Tindall
authors.forename: Diane M
authors.initials: DM
authors.lastname: Robins
authors.forename: Norman M
authors.initials: NM
authors.lastname: Greenberg
authors.forename: Mary J C
authors.initials: MJ
authors.lastname: Hendrix
authors.forename: Suresh
authors.initials: S
authors.lastname: Mohla
authors.forename: Robert H
authors.initials: RH
authors.lastname: Getzenberg
authors.forename: John T
authors.initials: JT
authors.lastname: Isaacs
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Pienta
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology; D000728:Androgens / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D000726:Androgen Antagonists; D000728:Androgens; D011944:Receptors, Androgen