title: Animal models of multiple system atrophy.
abstract: Multiple system atrophy (MSA) is a fatal neurodegenerative disorder presenting with autonomic failure and motor impairment, primarily comprising L-dopa-resistant parkinsonism but occasionally involving cerebellar ataxia. These features result from progressive multisystem neuronal loss that is associated with oligodendroglial alpha-synuclein inclusions. The growing number of animal models for MSA reflects the search for a preclinical test-bed for elucidating MSA pathogenesis and for developing novel therapeutic interventions. Here, the currently available MSA animal models will be reviewed and leads for future research will be identified.
authors.affiliation: Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.
authors.forename: Nadia
authors.initials: N
authors.lastname: Stefanova
authors.forename: François
authors.initials: F
authors.lastname: Tison
authors.forename: Markus
authors.initials: M
authors.lastname: Reindl
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Gregor K
authors.initials: GK
authors.lastname: Wenning
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D019578:Multiple System Atrophy / Q000473:pathology* / Q000503:physiopathology; D051381:Rats