A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methods.
This article is a report of the design and methods of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. This longitudinal, population-based study was initiated to investigate the genetic determinants of cardiovascular disease and its risk factors. Between October 2000 and April 2004, this family study enrolled 1,214 Eskimos from several coastal villages in the Norton Sound region of Western Alaska. Examinations included a physical, laboratory determinations, and measures of subclinical disease. This study will generate a genome-wide scan for loci influencing cardiovascular disease-related traits. Relations between subclinical atherosclerosis and markers of inflammation will be examined using historic and newly drawn samples. The study will provide data on CVD prevalence, risk factors and the relative contribution of genetic and environmental determinants in Alaska Native peoples. Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations.
Howard
Barbara V
BV
MedStar Research Institute, Washington, DC, USA. Barbara.v.howard@medstar.net
Devereux
Richard B
RB
Cole
Shelley A
SA
Davidson
Michael
M
Dyke
Bennett
B
Ebbesson
Sven O E
SO
Epstein
Stephen E
SE
Robinson
David R
DR
Jarvis
Betty
B
Kaufman
David J
DJ
Laston
Sandra
S
MacCluer
Jean W
JW
Okin
Peter M
PM
Roman
Mary J
MJ
Romenesko
Terry
T
Ruotolo
Giacomo
G
Swenson
Michael
M
Wenger
Charlotte R
CR
Williams-Blangero
Sarah
S
Zhu
Jianhui
J
Saccheus
Clarence
C
Fabsitz
Richard R
RR
Robbins
David C
DC
D000328:Adult; D000368:Aged; D000413:Alaska / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000235:genetics*; D015340:Epidemiologic Research Design; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D005838:Genotype; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D004930:Inuit; D008019:Life Style / Q000208:ethnology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011159:Population Surveillance / Q000379:methods; D012307:Risk Factors
D018836:Inflammation Mediators