title: [Expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance].
abstract: OBJECTIVE
  To investigate the expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance.
  
  
  METHODS
  RT-PCR method was used to examine the expression of TGF-beta1 mRNA in normal and carcinomatous prostate tissues.
  
  
  RESULTS
  The relative content of TGF-beta1 mRNA of normal prostate tissues was (0.74 +/- 0.11), while those of carcinomatous prostate tissues at T1-T2 and T3-T4 stages were (0.69 +/- 0.10) and (0.44 +/- 0.08) respectively, with significant difference between T1-T2 and T3-T4 (P < 0.05). And the relative contents of TGF-beta1 mRNA of carcinomatous prostate tissues with Gleason score < or = 5, 6-8 and > or = 9 were (0.70 +/- 0.12), (0.54 +/- 0.11) and (0.42 +/- 0.09) respectively.
  
  
  CONCLUSIONS
  The expression of TGF-beta1 mRNA was negatively correlated with the clinical stage and Gleason score of prostate carcinoma.
authors.affiliation: Department of Urology, the No. 1 Hospital of China Medical University, Shenyang, Liaoning 110001, China. lizheliang@hotmail.com
authors.forename: Ze-liang
authors.initials: ZL
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Li
authors.forename: Chui-ze
authors.initials: CZ
authors.lastname: Kong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D016212:Transforming Growth Factor beta