title: Self-reported effects of methadone on cigarette smoking in methadone-maintained subjects.
abstract: Subjects maintained on methadone evidence a high level of interest in quitting cigarette smoking. Readiness to quit may result, at least partially, from direct pharmacological interactions between methadone and brain nicotinic acetylcholine receptors. The aim of the present study was to assess: (1) self-reported changes in smoking habits after admission to a methadone maintenance treatment (MMT) program; (2) acute effects of methadone administration on smoking behavior in MMT patients. The study was conducted between May and December 2001, in two public outpatient MMT clinics located in Warsaw, Poland. The patients (41 men, 30 women) reported smoking fewer cigarettes after admission to the program. Most subjects (67.6%) changed their favorite brand of cigarettes after admission. Mean nicotine content (mg/cigarette) significantly decreased. On the other hand, the subjects did not report any effects of methadone administration on smoking parameters. The above findings suggest that initiation of MMT is associated with positive changes in smoking behavior. However, these changes may not be related to direct pharmacological interactions between methadone and nicotine.
authors.affiliation: Department of Prevention and Treatment of Addictions, Institute of Psychiatry and Neurology, 9 Sobieskiego St., PL-02957 Warsaw, Poland.
authors.forename: Helena
authors.initials: H
authors.lastname: Baran-Furga
authors.forename: Karina
authors.initials: K
authors.lastname: Chmielewska
authors.forename: Anna
authors.initials: A
authors.lastname: Bogucka-Bonikowska
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Habrat
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kostowski
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Bienkowski
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000627:therapeutic use*; D011044:Poland; D012650:Self Disclosure; D012907:Smoking; D016540:Smoking Cessation; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D008691:Methadone