title: Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol.
abstract: The cationic complexes (1,2-diaminoethane)(maltolato)platinum(II) ([Pt(en)(ma)]+) and (1R,2R-1,2-diaminocyclohexane)(maltolato)platinum(II) ([Pt(R,R-DACH)(ma)]+) have been prepared and the structure of [Pt(R,R-DACH)(ma)]NO3 has been determined by single crystal X-ray diffraction. The geometry of the metal in [Pt(R,R-DACH)(ma)]NO3 is essentially square planar and the maltolate ligand has a geometry similar to other chelate complexes involving this ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and the IC50 values are approximately 32 microM in HeLa cells and 26 microM in K562 cells. In these cell lines the cytotoxicity of cisplatin is higher than the maltolate complexes by a factor of 2 to 3 whereas the cytotoxicity of carboplatin is lower than the maltolate complexes.
authors.affiliation: School of Chemistry, The University of Melbourne, Melbourne, Vic. 3010, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Carland
authors.forename: Kristine J
authors.initials: KJ
authors.lastname: Tan
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: White
authors.forename: Jodie
authors.initials: J
authors.lastname: Stephenson
authors.forename: Vincent
authors.initials: V
authors.lastname: Murray
authors.forename: William A
authors.initials: WA
authors.lastname: Denny
authors.forename: W David
authors.initials: WD
authors.lastname: McFadyen
mesh_terms: D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011753:Pyrones / Q000737:chemistry*
chemical_list: D003959:Diamines; D017671:Platinum Compounds; D011753:Pyrones; C008316:maltol