Neural surveillance of skeletal homeostasis.
Endowed with sympathetic and peptidergic nerves, the vertebrate skeleton is under constant surveillance by the nervous system. In addition to pituitary hormone secretion, centrally regulated sympathetic release, as elegantly demonstrated by Karsenty and colleagues, integrate to control both components of skeletal remodeling, osteoblastic bone formation, and osteoclastic bone resorption (Elefteriou et al., 2005).
Zaidi
Mone
M
Department of Medicine and The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, New York 10029, USA.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D013564:Sympathetic Nervous System / Q000378:metabolism*