Eunicellin-based diterpenoids, australins A-D, isolated from the soft coral Cladiella australis.
The EtOAc extract of a Taiwanese soft coral, Caldiella australis, yielded four new eunicellin-based diterpenoids, australins A-D (1-4). The chemical structures of these metabolites were determined on the basis of extensive spectroscopic (including 1D and 2D NMR) analyses and by comparison of their NMR spectral data with those of related metabolites. Metabolite 2 was found to possess a moderate cytotoxic activity against selected breast and liver cancer cell lines.
Ahmed
Atallah F
AF
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
Wu
Ming-Hsuan
MH
Wang
Guey-Horng
GH
Wu
Yang-Chang
YC
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; C476503:eunicellin