Human p53 tumor suppressor gene (TP53) and schizophrenia: case-control and family studies.
The human p53 tumor suppressor gene (TP53) is considered as a candidate susceptibility gene for schizophrenia because of its functions in neurodevelopment. To test for an association between TP53 and schizophrenia, both the case-control study and the transmission disequilibrium test (TDT) were performed on genotype data from eight polymorphisms in TP53. Our samples included 286 Toronto schizophrenia cases and 264 controls, and 163 Portuguese nuclear families. In the Toronto case-control study significant differences of allele frequencies of the CAA Ins/Del (p=0.027) and the 16bp Ins/Del (p=0.022) were detected. In TDT analysis we found significant differences for transmission of the CAA Ins/Del (p=0.017) in Portuguese schizophrenia families. Haplotype analysis also showed a significant association between TP53 and schizophrenia. These results provide further evidence that TP53 may play a role in the pathogenesis of schizophrenia.
Ni
Xingqun
X
Neuroscience Research Department, Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Canada M5T 1R8.
Trakalo
Joseph
J
Valente
Jose
J
Azevedo
Maria H
MH
Pato
Michelle T
MT
Pato
Carlos N
CN
Kennedy
James L
JL
D001923:Brain Chemistry / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D009864:Ontario / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics; D011174:Portugal / Q000453:epidemiology; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53