Botulinum toxin a in the treatment of chromhidrosis.
BACKGROUND
Chromhidrosis is an uncommon disorder characterized by secretion of colored sweat by apocrine glands, typically localized to the face or axilla. The current treatments available for chromhidrosis are time consuming and frequently ineffective.


OBJECTIVE
Our purpose is to demonstrate a novel approach to the treatment of apocrine chromhidrosis.


METHODS
We report a case of apocrine chromhidrosis successfully treated with botulinum toxin A (BTX-A; Botox).


RESULTS
BTX-A therapy successfully controlled facial chromhidrosis, and the effects were visible at 19 weeks post-treatment. The therapeutic benefits may be attributed to its inhibitory effects on cholinergic stimulation, adrenergic stimulation, and substance P release, although further studies are necessary to elucidate the precise mechanism of action.


CONCLUSIONS
This report demonstrates a new therapeutic approach to patients suffering from chromhidrosis.
Wu
Jessie M
JM
School of Medicine, University of Sheffield, UK.
Mamelak
Adam J
AJ
Nussbaum
Rachel
R
McElgunn
Patrick S J
PS
D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage*; D002610:Cheek / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence; D013543:Sweat Gland Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
D009465:Neuromuscular Agents; D001905:Botulinum Toxins