[The expression of ICAM-1 in laryngeal carcinoma and it's significance].
OBJECTIVE
To study the expression of ICAM-1 in laryngeal carcinoma and it's significance.


METHODS
ICAM-1 were detected in 78 cases laryngeal carcinoma, 30 cases dysplasia and 5 cases normal by SP immunohistochemistry.


RESULTS
ICAM-1 can be expressed on the lymphocytes of patients with laryngeal carcinoma, but not cells of normal, dysplasia and cancer. The first and second stages laryngeal carcinoma had stronger ICAM-1 expression than those of the third and fourth stages (P < 0.05). ICAM-1 expression in laryngeal carcinoma with cervical metastasis was higher than that without cervical metastasis (P < 0.05). Three and five years survival rate in patients with higher ICAM-1 expression were higher than those of patients with lower ICAM-1 expression (P < 0.05).


CONCLUSIONS
These results implicate that the development, metastasis and prognosis of laryngeal carcinoma may be correlated to ICAM-1 expression of lymphocyte.
Wang
Mingfang
M
Department of Otorhinolaryngology, the Affiliated Hospital of Henan Science and Technology University, Luoyang, 471003, China. wmf@mail.haust.edu.cn
Zhang
Chao
C
Xing
Luqi
L
Lu
Eryong
E
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009333:Neck; D011379:Prognosis
D018799:Intercellular Adhesion Molecule-1