title: Incidence of hypertrophic scars among African Americans linked to vitamin D-3 metabolism?
abstract: The pathogenesis and progression of wound-healing involve intricate pathways and numerous chemical mediators. This remains an area of intense study as undesirable results of this process, such as hypertrophic scars and keloids, can result in significant morbidity. These lesions are distinct in their characteristics, although they are similar in their distribution in patients with darker skin colors. There is a robust inflammatory mechanism behind the formation of hypertrophic scars and keloids. Furthermore, their development may be intimately related to vitamin D-3, which has been shown to be a powerful anti-inflammatory agent. This chemical is made in the skin, whose production is influenced by various factors of which the amount of melanin is a crucial one. More specifically, an increase in pigmentation has been shown to decrease the amount of vitamin D-3 synthesis in the skin. Thus, this paper proposes the hypothesis linking the propensity of inflammation and subsequent scarring in darker-skinned individuals to the reduced levels of vitamin D-3 production in their skin.
authors.affiliation: Department of Surgery, Medicine and Organismal Biology & Anatomy, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA.
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Cooke
authors.forename: Anna
authors.initials: A
authors.lastname: Chien
authors.forename: Amy
authors.initials: A
authors.lastname: Brodsky
authors.forename: Raphael C
authors.initials: RC
authors.lastname: Lee
mesh_terms: D001741:Black or African American / Q000235:genetics / Q000706:statistics & numerical data*; D002762:Cholecalciferol / Q000172:deficiency* / Q000378:metabolism; D017439:Cicatrix, Hypertrophic / Q000453:epidemiology / Q000208:ethnology* / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000378:metabolism*; D008543:Melanins / Q000378:metabolism; D012880:Skin Pigmentation; D014945:Wound Healing
chemical_list: D008543:Melanins; D002762:Cholecalciferol