title: [Effects of different penetration enhancers on percutaneous absorption of lappaconitine gel in vitro].
abstract: OBJECTIVE
  To study the effects of different penetration enhancers on the transcutaneous permeability of lappaconitine gel in vitro and therefore to screen out the effective accelerator to enhance the permeation rate of lappaconitine.
  
  
  METHODS
  Using improved Franz-type diffusion cell and excised big mouse skin in vitro as transdermal barrier, the kinetics parameters such as cumulative permeation quantity, permeation rate and permeation lagged time were determined by HPLC. The enhancement ability of four different enhancers such as azone (Azone), propylene glycol (PG), oleic acid (OA) and lauryl alcohol (LA), was investigated when used either uniquely or combinatively each other at random.
  
  
  RESULTS
  When used combinatively, Azone + PG, LA + PG, OA + PG can enhance the cumulative permeation quantity, OA + PG was the best one among them.
  
  
  CONCLUSIONS
  The selection of the best penetration enhancers provided reference for lappaconitine transdermal delivery.
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100102, China. wangyzi@sina.com
authors.forename: Ying-zi
authors.initials: YZ
authors.lastname: Wang
authors.forename: Tian-chi
authors.initials: TC
authors.lastname: Ren
authors.forename: Yong-qing
authors.initials: YQ
authors.lastname: Xiao
mesh_terms: D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000279:Administration, Cutaneous; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D007851:Dodecanol / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D019301:Oleic Acid / Q000494:pharmacology*; D019946:Propylene Glycol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D001381:Azepines; D004338:Drug Combinations; D007851:Dodecanol; C035229:laurocapram; D019301:Oleic Acid; D019946:Propylene Glycol; D000157:Aconitine; C022150:lappaconitine