title: Changes in quality of life among low-income men treated for prostate cancer.
abstract: OBJECTIVE
  To investigate as the primary objective changes over time in general and disease-specific health-related quality of life (HRQOL) among low-income men treated for prostate cancer in a longitudinal prospective study.
  
  
  METHODS
  Study participants were recruited from a state-funded program providing free prostate cancer treatment to impoverished men. We included men who completed telephone interviews and self-administered questionnaires at study enrollment and 6 months of follow-up. Covariates univariately associated with HRQOL change scores were included in multivariate linear regression models. All HRQOL models were controlled for age at enrollment, race, baseline HRQOL, and treatment effects at baseline and follow-up.
  
  
  RESULTS
  Subjects with greater baseline Gleason scores experienced more negative changes in their physical health than did men with lower Gleason scores. Men with less than a high school education experienced greater improvement in their mental well-being than did men with more than a high school education. Those experiencing treatment effects at baseline displayed greater positive changes in their urinary function than did those without treatment effects at baseline. Finally, men experiencing treatment effects at follow-up were characterized by profound reductions in sexual function compared with those free of treatment effects at follow-up.
  
  
  CONCLUSIONS
  This work provides new insights into HRQOL over time in a low-income, multiethnic group of patients with prostate cancer.
authors.affiliation: Department of Urology, Jonsson Comprehensive Cancer Center, University of California, Health Services, Los Angeles, California 90095, USA.
authors.forename: Rondeep
authors.initials: R
authors.lastname: Brar
authors.forename: Sally L
authors.initials: SL
authors.lastname: Maliski
authors.forename: Lorna
authors.initials: L
authors.lastname: Kwan
authors.forename: Tracey L
authors.initials: TL
authors.lastname: Krupski
authors.forename: Mark S
authors.initials: MS
authors.lastname: Litwin
mesh_terms: D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011203:Poverty; D011471:Prostatic Neoplasms / Q000628:therapy*; D011788:Quality of Life