title: Paraneoplastic chorea with leukoencephalopathy presenting with obsessive-compulsive and behavioral disorder.
abstract: Chorea is a rare manifestation of paraneoplastic disease and is associated with CV2/CRMP-5 antibodies. Obsessive-compulsive disorder and large-scale white matter abnormalities on MRI have not been previously reported in association with these antibodies. We report on a case of CV2 paraneoplastic syndrome with obsessive-compulsive behavior preceding the motor manifestations of chorea with associated leukoencephalopathy on MRI. The literature on paraneoplastic chorea is reviewed.
authors.affiliation: Department of Neurology, Movement Disorders Center, University of Florida College of Medicine, Gainesville, Florida, USA. muehlschlegel@neurology.ufl.edu
authors.forename: Susanne
authors.initials: S
authors.lastname: Muehlschlegel
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Foote
authors.forename: Dominique
authors.initials: D
authors.lastname: Coco
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Yachnis
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Fernandez
mesh_terms: D000368:Aged; D001344:Autopsy / Q000379:methods; D002421:Caudate Nucleus / Q000473:pathology; D002819:Chorea / Q000150:complications* / Q000473:pathology; D015140:Dementia, Vascular / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000473:pathology