Reduced vascular reactivity after chronic nitroglycerine administration: EDHF mechanism is also downregulated.
von der Weid
Pierre-Yves
PY
Mucosal Inflammation and Smooth Muscle Research Groups, Department of Physiology & Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. vonderwe@ucalgary.ca
Coleman
Harold A
HA
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology; D001685:Biological Factors / Q000378:metabolism; D015536:Down-Regulation; D004361:Drug Tolerance; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*
D000975:Antioxidants; D001685:Biological Factors; D024681:Potassium Channels, Calcium-Activated; D014665:Vasodilator Agents; C067410:endothelium-dependent hyperpolarization factor; D005996:Nitroglycerin; D001205:Ascorbic Acid