The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease.
In 927 biologically unrelated Caucasian patients with coronary artery disease it was investigated whether the NcoI restriction fragment length polymorphism of the muscle-specific creatine kinase (CKMM) gene is associated with aerobic power and with the response to physical training. Physical training significantly (P<0.001) increased peak oxygen consumption in the GG, AG and AA NcoI genotypes. Covariate-adjusted peak oxygen consumption at baseline, after training and the response to training were not different across CKMM NcoI genotypes.
Defoor
Johan
J
Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, K.U. Leuven, Leuven, Belgium.
Martens
Kevin
K
Matthijs
Gert
G
Zieliñska
Dominika
D
Schepers
Dirk
D
Philips
Tim
T
Vlietinck
Robert
R
Fagard
Robert
R
Vanhees
Luc
L
D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics*; D052283:Creatine Kinase, MM Form / Q000235:genetics*; D005080:Exercise Test; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D044465:White People
D052283:Creatine Kinase, MM Form