title: Pharmacokinetics of therapeutic monoclonal antibodies used in oncology.
abstract: This review presents the clinical pharmacokinetics of the marketed therapeutic monoclonal antibodies used in oncology. Aspects regarding absorption, tissue distribution, elimination as well as factors influencing pharmacokinetics, pharmacodynamics and kinetic interactions are also discussed.
authors.affiliation: Hôspital de Hautepierre, pharmacie, Avenue Molière, 67000 Strasbourg. dominique.leveque@chru-strasbourg.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Levêque
authors.forename: Sandra
authors.initials: S
authors.lastname: Wisniewski
authors.forename: François
authors.initials: F
authors.lastname: Jehl
mesh_terms: D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D018796:Immunoconjugates / Q000493:pharmacokinetics; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D018796:Immunoconjugates