No evidence of plasticity in hair follicles of recipients after allogeneic hematopoietic stem cell transplantation.
Here we show in a prospective quantitative study of 115 patients after allogeneic hematopoietic stem cell transplantation that hair follicles remain exclusively of recipient type despite full whole blood donor-type chimerism. Our data indicate that unmanipulated hematopoietic donor stem cells do not contribute directly to reconstitution even in an organ at highest need for repair.
Rovó
Alicia
A
Division of Hematology, University Hospital Basel, Basel, Switzerland. aliciarovo@bluewin.ch
Meyer-Monard
Sandrine
S
Heim
Dominik
D
Arber
Caroline
C
Passweg
Jakob R
JR
Gratwohl
Alois
A
Tichelli
André
A
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D018859:Hair Follicle / Q000166:cytology / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012038:Regeneration / Q000502:physiology*; D018183:Transplantation Chimera / Q000502:physiology*