Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc.
Novel bifunctional chelating agents bearing an aromatic rigid backbone have been synthesized and characterized on the basis of spectroscopic techniques. These macrocyclic multidentate chelating agents were conjugated with monoclonal antibody which forms stable complexes with 99mTc with high radiochemical purity.
Chhikara
Bhupender S
BS
Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
Kumar
Nitin
N
Tandon
Vibha
V
Mishra
Anil K
AK
D000473:Alkanes / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007553:Isotope Labeling; D015394:Molecular Structure; D013440:Sulfides / Q000737:chemistry*; D013667:Technetium / Q000032:analysis*
D000473:Alkanes; D002614:Chelating Agents; D013440:Sulfides; D013667:Technetium