[Some interactions of natural and synthetic anionic polymers with biologically active substances].
Anionic polymers are nowadays extensively used in drug form technology, especially in drug delivery and drug targeting. Development of proper drug and macromolecular excipient composition allows controlled drug delivery in the term of the drug concentration in blood or other tissues, and in the term of the action-time. Between anionic polymers most frequently carbopols, eudragits, alginates and pectins are used. Application of anionic polymers in drug form technology is an up to date problem. According to new synthesis methods and new anionic polymers, new drug delivery systems would be researched. Most selective and safe devices should be developed, concerning biodegradation aspects.
Musiał
Witold
W
Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku Akademia Medyczna we Wrocławiu. witold@bf.uni.wroc.pl1
Kubis
Aleksander A
AA
D000180:Acrylic Resins; D000464:Alginates / Q000493:pharmacokinetics; D000818:Animals; D000838:Anions; D001673:Biodegradation, Environmental; D001692:Biological Transport; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006801:Humans; D010368:Pectins / Q000493:pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids / Q000493:pharmacokinetics; D011145:Polyvinyls / Q000493:pharmacokinetics; D011480:Protease Inhibitors / Q000493:pharmacokinetics
D000180:Acrylic Resins; D000464:Alginates; D000838:Anions; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D011480:Protease Inhibitors; C006912:carboxypolymethylene; C038300:methylmethacrylate-methacrylic acid copolymer; D010368:Pectins