title: [Study on independent factors on the prognosis of colorectal carcinoma: TNM stage, tumor budding, perineural invasion, peritumoral-lymphocytic infiltration and urine glucose].
abstract: OBJECTIVE
  To study the influence of clinical and pathological-morphological parameters on the prognosis of colorectal carcinoma.
  
  
  METHODS
  Univariate and multivariate Cox proportional hazard model were used to study the influence of clinical and pathological-morphological factors on the prognosis in 226 colorectal carcinoma cases.
  
  
  RESULTS
  Using univariate analysis, data showed that the factors significantly related to disease prognosis would include: the depth of direct spread, vessel invasion, perineural invasion, tumor budding, peritumoral-lymphocytic infiltration, Crohn-like reaction, number of positive lymph nodes, distant metastasis, TNM stage and urine glucose. Multivariate Cox proportional hazard model showed that six factors were identified to be associated with higher relative-risk (RR), including: older age, advanced TNM stage, more severe budding, perineural invasion, less peritumoral-lymphocytic infiltration and urine glucose.
  
  
  CONCLUSIONS
  Age, TNM stage, tumor budding, perineural invasive, peritumoral-lymphocytic infiltration and urine glucose were independent predictors to the prognosis of colorectal carcinoma.
authors.affiliation: Department of Pathology and Pathophysiology, Centre for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China.
authors.forename: Fang-ying
authors.initials: FY
authors.lastname: Xu
authors.forename: Jian-kang
authors.initials: JK
authors.lastname: Dong
authors.forename: Yi-min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Mei-juan
authors.initials: MJ
authors.lastname: Qu
authors.forename: Fen-juan
authors.initials: FJ
authors.lastname: Wang
authors.forename: Yi-sen
authors.initials: YS
authors.lastname: Jin
authors.forename: Guo-ping
authors.initials: GP
authors.lastname: Ren
authors.forename: Mao-de
authors.initials: MD
authors.lastname: Lai
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006029:Glycosuria; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors