title: Late sequelae of radiotherapy in adults.
abstract: Around 3-5 million cancer patients receive radiotherapy worldwide every year. Improved cure rates have led to physicians being confronted with a range of late radiation sequelae, broadly of two types-late effects on normal tissues (LENT) and radiation-induced second malignancies (RISM). These late changes affect the function and quality of life of cancer survivors, increase with increasing radiation dose and show a relationship with time. Overall risks for LENT and RISM are 5-10% and 2-10%, respectively, and the potential benefits of radiotherapy outweigh these risks.
authors.affiliation: Department of Radiotherapy, Institute Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences (AIIMS), Ansari Nagar, 110029 New Delhi, India. drbkmohanti@rediffmail.com
authors.forename: Bidhu K
authors.initials: BK
authors.lastname: Mohanti
authors.forename: Manishi
authors.initials: M
authors.lastname: Bansal
mesh_terms: D000328:Adult; D003238:Connective Tissue / Q000528:radiation effects*; D006801:Humans; D007194:India; D009369:Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects*