[A comparative study of the dynamics of deep burns healing in using medullary allogenic fibroblast-like mesenchymal stem cells from bone marrow immobilized on biodegrading membranes or taken from cultural plastic].
Transplantation of suspention of allogenic fibroblast-like mesenchymal stem cells (AFMSC) of the bone marrow and AFMSC immobilized on the biodegradable membrane (BM) stimulates healing of deep burn wounds compared to control (without cell transplantation) because these cells produce biologically active substances into the wound. AFMSC immobilized on BM activate repair processes in the wounds earlier. This may be due to their higher functional activity created in the monolayer by adequate intercellular interactions. To avoid complications caused by low diffuse properties of BM (protein precipitation), BM should be removed from the surface of the burn wound maximum 3 days after its application.
Rasulov
M F
MF
Sevast'ianov
V I
VI
Egorova
V A
VA
Bogatyrev
S R
SR
Zaĭdenov
V A
VA
Potapov
I V
IV
Onishchenko
N A
NA
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000166:cytology; D002056:Burns / Q000473:pathology / Q000628:therapy*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D018914:Cells, Immobilized; D005347:Fibroblasts / Q000166:cytology; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D033581:Stem Cell Transplantation / Q000379:methods*
D001672:Biocompatible Materials