title: Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones.
abstract: A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.
authors.affiliation: Departamento de Antibioticos, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50670-901 Recife, Brasil.
authors.forename: R H
authors.initials: RH
authors.lastname: Mourão
authors.forename: T G
authors.initials: TG
authors.lastname: Silva
authors.forename: A L M
authors.initials: AL
authors.lastname: Soares
authors.forename: E S
authors.initials: ES
authors.lastname: Vieira
authors.forename: J N
authors.initials: JN
authors.lastname: Santos
authors.forename: M C A
authors.initials: MC
authors.lastname: Lima
authors.forename: V L M
authors.initials: VL
authors.lastname: Lima
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: J
authors.initials: J
authors.lastname: Barbe
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000401:mortality; D004353:Drug Evaluation, Preclinical; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: C507737:3-benzyl-5-acridinylidene-thiazolidine-2,4-dione; C507736:5-benzylidene-3-(4-methyl-benzyl)-thiazolidine-2,4-dione; D000166:Acridines; D001593:Benzyl Compounds; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D014280:Triglycerides; D000077154:Rosiglitazone