Hair cycle induction by hair plucking in Mini rats.
Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a transgenic rat in which the growth hormone (GH) expression is suppressed by the presence of an antisense transgene for the rat GH gene, and the hair cycle of male Mini rats enters a long-lasting telogen phase after 8 weeks old. In the present study, effects of hair plucking on the hair cycle in the dorsal skin of 11-week-old male Mini rats were examined up to 54 days after the hair plucking. As a result, hair plucking brought about an anagen phase, and hair cycle arrest in telogen phase occurred again. Male Mini rats, having follicles in anagen-inducible long-lasting telogen phase, will offer a powerful tool for investigating the molecular nature and organization of the so-called hair cycle clock.
Umeda-Ikawa
Aya
A
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan.
Ishii
Yoshiyuki
Y
Doi
Kunio
K
D000818:Animals; D030801:Animals, Genetically Modified; D013006:Growth Hormone / Q000172:deficiency; D006197:Hair / Q000502:physiology*; D018859:Hair Follicle / Q000502:physiology*; D006204:Hair Removal; D008297:Male; D051381:Rats
D013006:Growth Hormone