Phosphoinositide lipid second messengers: new paradigms for calcium channel modulation.
Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" G(q/11)-mediated signal.
Delmas
Patrick
P
Laboratoire de Neurophysiologie Cellulaire, CNRS, UMR 6150, Faculté de Médecine, IFR Jean Roche, Bd. Pierre Dramard, 13916 Marseille Cedex 20, France. delmas.p@jean-roche.univ-mrs.fr
Coste
Bertrand
B
Gamper
Nikita
N
Shapiro
Mark S
MS
D000818:Animals; D015220:Calcium Channels / Q000145:classification / Q000502:physiology*; D008958:Models, Molecular; D008959:Models, Neurological; D010716:Phosphatidylinositols / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*
D015220:Calcium Channels; D010716:Phosphatidylinositols