title: On the road to bioremediation of "dioxin".
abstract: Mohammadi and Sylvestre report engineering of a dioxygenase to create an enzyme that attacks dibenzofuran in the lateral position. Subsequent oxidation and a second dioxygenation produced ring-open products. All metabolites were unambiguously identified by 1H-NMR. This new pathway targets degradation of chlorinated dibenzofurans.
authors.affiliation: Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps-Universität, D-35032 Marburg, Germany. buckel@staff.uni-marburg.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Buckel
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D001673:Biodegradation, Environmental; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000737:chemistry / Q000378:metabolism*; D049308:Dioxygenases / Q000737:chemistry / Q000378:metabolism*; D004785:Environmental Pollutants / Q000378:metabolism* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010105:Oxygenases / Q000737:chemistry / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D010105:Oxygenases; D049308:Dioxygenases; C108163:dioxin dioxygenase