Endothelial function in pediatric patients on peritoneal dialysis: the need for data.
Cardiovascular complications are emerging as the primary cause of death for patients with childhood end-stage renal disease. Children with end-stage renal failure are subjected to many of the risk factors for cardiovascular disease identified in adult patients. Dysfunction of the endothelium is presently regarded as a first but reversible step in the development of atherosclerosis. Noninvasive techniques to assess endothelial function have been recently developed and have been proven to predict future mortality in adult patients. These techniques are readily applicable to pediatric patients. Endothelial dysfunction has been demonstrated in children in all stages of renal failure. Data on pediatric patients treated with peritoneal dialysis are currently lacking, however. Considering the abundance of cardiovascular risk factors specific to treatment with peritoneal dialysis, such studies should be initiated.
Lilien
Marc R
MR
Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands. m.lilien@wkz.azu.nl
Schröder
Cornelis H
CH
Koomans
Hein A
HA
D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D014652:Vascular Diseases / Q000209:etiology / Q000503:physiopathology*