title: [Oxidative stress parameter analysis in rat brains during long-term ethanol intoxication].
abstract: The aim of this research was to define the influence of long-term ethanol intoxication on the changes in end products of lipid peroxidation, reacting with thiobarbituric acid (TBA-reactive products) and free SH-groups concentrations in rat brains. The experiment was conducted on male Lewis rats. The experimental groups received a 1-molar ethanol solution and the control group received tap water. The animals were killed after 4, 8 and 12 weeks of intoxication and their brains were collected for further examination, encompassing measurement of the concentration of TBA-reactive products and free SH-groups. A statistically significant increase in the concentration of TBA-reactive products in 4th week of intoxication and decrease in the concentration of free SH-groups in 8th and 12th week of intoxication--compared to the control group--was noticed.
authors.affiliation: Zakład Medycyny Sadowej Uniwersytetu Medycznego w Lodzi. mbarzdo@wp.pl
authors.forename: Maciej
authors.initials: M
authors.lastname: Barzdo
authors.forename: Ewa
authors.initials: E
authors.lastname: Gloc
authors.forename: Agnieszka P
authors.initials: AP
authors.lastname: Jurczyk
authors.forename: Ewa
authors.initials: E
authors.lastname: Meissner
authors.forename: Beata
authors.initials: B
authors.lastname: Jankowska
authors.forename: Jarosław
authors.initials: J
authors.lastname: Berent
authors.forename: Stefan
authors.initials: S
authors.lastname: Szram
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D013438:Sulfhydryl Compounds / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D013438:Sulfhydryl Compounds; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol