Azadirachtin derivatives from seed kernels of Azadirachta excelsa.
Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11alpha-azadirachtin H (7), 11beta-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were established by spectroscopic techniques, and the structure of 3 was confirmed by X-ray analysis. Compounds 1-7 and 9 exhibited toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 0.75-1.92 microg/g body weight, in 92 h.
Kanokmedhakul
Somdej
S
Department of Chemistry, Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. somdej@kku.ac.th
Kanokmedhakul
Kwanjai
K
Prajuabsuk
Thirada
T
Panichajakul
Sanha
S
Panyamee
Piyanan
P
Prabpai
Samran
S
Kongsaeree
Palangpon
P
D000818:Animals; D031601:Azadirachta / Q000737:chemistry*; D018360:Crystallography, X-Ray; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009036:Moths / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013785:Thailand
D036701:Limonins; C010329:azadirachtin