title: AMPK and p53 help cells through lean times.
abstract: Cells that encounter low nutrient conditions often respond by arresting cell division or becoming apoptotic. Recent work by Jones and colleagues (Jones et al.,2005) reveals how the AMP-activated kinase mediates this process by phosphorylating and activating the tumor suppressor p53.
authors.affiliation: The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
authors.forename: Carson C
authors.initials: CC
authors.lastname: Thoreen
authors.forename: David M
authors.initials: DM
authors.lastname: Sabatini
mesh_terms: D055372:AMP-Activated Protein Kinases; D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D002477:Cells / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D016159:Tumor Suppressor Protein p53; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose