[Normodipin in correction of platelet rheology in hypertensive patients with metabolic syndrome].
OBJECTIVE
To determine a therapeutic effect of normodipin on intravascular platelet activity in patients with arterial hypertension (AH) and metabolic syndrome (MS).


METHODS
Twenty patients received normodipin for one month in a dose 10 mg/day. The drug activity was assessed by dynamics of anthropometric indices, lipid spectrum of the blood, lipid peroxidation in plasma and platelets, antioxidant protection of blood liquid and platelets, intravascular platelet activity. The results were processed statistically.


RESULTS
Normodipin in hypertensive patients with MS has a positive effect on peroxidation and platelet aggregation. Long-term normodipin administration promoted stabilization of the effect.


CONCLUSIONS
To reduce body mass in hypertensive patients with MS it is necessary to combine normodipin administration with nonpharmacological medication.
Medvedev
I N
IN
Gromnatskiĭ
N I
NI
D017311:Amlodipine / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
D008055:Lipids; D017311:Amlodipine