Imaging the renin-angiotensin- aldosterone system in the heart.
The influence of the renin-angiotensin system (RAS) is recognized in cardiac and vascular injury. An extrinsic RAS has been known for decades, and an equally important intrinsic RAS has been discovered recently. The latter leads to pathologic tissue alterations in the absence of systemic stimuli and may be the main source of local tissue effects of RAS. A new radiotracer fluorobenzoyl-lisinopril was synthesized by radiolabeling benzoic acid active ester with 18F and reacting that with the epsilon-amino group of lisinopril. The presence of angiotensin-converting enzyme (ACE) activity and angiotensin II receptors was examined in relation to myocardial fibrosis. This tissue-specific radioligand represents the first study of ACE in the human heart. This article presents preliminary data on imaging the RAS in the human cardiac tissue and discusses the potential for clinical application of these imaging techniques to human patients.
Shirani
Jamshid
J
Geisinger Medical Center, Division of Cardiology, 100 North Academy Avenue, Danville, PA 17822, USA. jshirani1@geisinger.edu
Loredo
Maria L
ML
Eckelman
William C
WC
Jagoda
Elaine M
EM
Dilsizian
Vasken
V
D000818:Animals; D004719:Endomyocardial Fibrosis / Q000188:drug therapy / Q000503:physiopathology*; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006333:Heart Failure / Q000000981:diagnostic imaging*; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D011945:Receptors, Angiotensin / Q000096:biosynthesis*; D012084:Renin-Angiotensin System; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D011945:Receptors, Angiotensin; D007703:Peptidyl-Dipeptidase A