title: Efficient internal pallidal stimulation in Gilles de la Tourette syndrome: a case report.
abstract: The usefulness of deep brain stimulation (DBS) of thalamic nuclei in Gilles de la Tourette syndrome (GTS) has recently been advocated. We report on a 14-month follow-up study of a patient with intractable GTS in whom bilateral DBS of the internal globus pallidus was carried out. Tic frequency per minute decreased by 73% in the postoperative phase and in particular the vocal tics became less intense. Pronation/ supination bradykinesia of the left extremities was a well-tolerated, permanent side effect. Pallidal DBS could become a valuable rescue therapy for otherwise intractable GTS.
authors.affiliation: Department of Neuroscience, Centre Hospitalier de Luxembourg, Luxembourg. diederdn@pt.lu
authors.forename: Nico J
authors.initials: NJ
authors.lastname: Diederich
authors.forename: Karin
authors.initials: K
authors.lastname: Kalteis
authors.forename: Mara
authors.initials: M
authors.lastname: Stamenkovic
authors.forename: Vannina
authors.initials: V
authors.lastname: Pieri
authors.forename: François
authors.initials: F
authors.lastname: Alesch
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods*; D005500:Follow-Up Studies; D007839:Functional Laterality; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D020323:Tics / Q000503:physiopathology / Q000628:therapy; D005879:Tourette Syndrome / Q000628:therapy*