title: Integrated treatment of first-episode psychosis: effect of treatment on family burden: OPUS trial.
abstract: BACKGROUND
  The families of patients with first-episode psychosis often play a major role in care and often experience lack of support.
  
  
  OBJECTIVE
  To determine the effect of integrated treatment v. standard treatment on subjective burden of illness, expressed emotion (EE), knowledge of illness and satisfaction with treatment in key relatives of patients with a first episode of schizophrenia-spectrum disorder.
  
  
  METHODS
  Patients with ICD-10 schizophrenia-spectrum disorders (first episode) were randomly assigned to integrated treatment or to standard treatment. Integrated treatment consisted of assertive community treatment, psychoeducational multi-family groups and social skills training. Key relatives were assessed with the Social Behaviour Assessment Schedule (SBAS, burden of illness), the 5-min speech sample (EE), and a multiple choice questionnaire at entry and after 1 year.
  
  
  RESULTS
  Relatives in integrated treatment felt less burdened and were significantly more satisfied with treatment than relatives in standard treatment. There were no significant effects of intervention groups on knowledge of illness and EE.
  
  
  CONCLUSIONS
  The integrated treatment reduced family burden of illness and improved satisfaction with treatment.
authors.affiliation: Bispebjerg Hospital, Department of Psychiatry, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. pj02@bbh.hosp.dk
authors.forename: Pia
authors.initials: P
authors.lastname: Jeppesen
authors.forename: Lone
authors.initials: L
authors.lastname: Petersen
authors.forename: Anne
authors.initials: A
authors.lastname: Thorup
authors.forename: Maj-Britt
authors.initials: MB
authors.lastname: Abel
authors.forename: Johan
authors.initials: J
authors.lastname: Oehlenschlaeger
authors.forename: Torben Ø
authors.initials: TØ
authors.lastname: Christensen
authors.forename: Gertrud
authors.initials: G
authors.lastname: Krarup
authors.forename: Ralf
authors.initials: R
authors.lastname: Hemmingsen
authors.forename: Per
authors.initials: P
authors.lastname: Jørgensen
authors.forename: Merete
authors.initials: M
authors.lastname: Nordentoft
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D017281:Cost of Illness; D019033:Delivery of Health Care, Integrated / Q000592:standards*; D019260:Expressed Emotion; D005190:Family / Q000523:psychology*; D005192:Family Health; D005260:Female; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012044:Regression Analysis; D012559:Schizophrenia / Q000628:therapy*; D011795:Surveys and Questionnaires