[Cardiac amyloidosis revealing multiple myeloma].
BACKGROUND
Amyloidosis is a rare disease characterized by an extracellular accumulation of a protein polysaccharid complex (Amyloid). Cardiac involvement is considered as a major prognostic factor.


METHODS
We report the case of two women, hospitalized for heart failure. The diagnosis of cardiac amyloidosis was suggested by echocardiography: Left ventricular concentric hypertrophy and typical amyeloid infiltration with hyperechoic, shiny and granite-like aspect of the interventricular septum. The histological confirmation was obtained by gastric biopsy in the first case and biopsy of the salivary glands in the second revealing an amyloidosis AL. This cardiac amyloidosis was secondary to multiple myeloma: monoclonal Gammopathy with immunoglobulin Lambda in the first and Kappa in the second, and the presence of a plasmocyte infiltration in the sternal puncture.


CONCLUSIONS
Amyloidosis is a rare pathology, the cardiac involvement is frequent in the type AL and can occur with or without clinical manifestations. Echocardiography should be systematic in patients with confirmed amyloidosis.
Denguir
Hichem
H
Service de cardiologie du CHU de Monastir.
Ben-Hamda
Khaldoun
K
Gharbi
Mostari
M
Addad
Faouzi
F
Hammami
Sonia
S
Mlika
Azmi
A
Abbes
Fehmi
F
Moussa
Adnene
A
Betbout
Fethi
F
Gamra
Habib
H
Maatouk
Faouzi
F
Dridi
Zohra
Z
Zakhama
Abdelfettah
A
Mahjoub
Sylvia
S
Ben-Farhat
Mohamed
M
D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology*; D001706:Biopsy; D004452:Echocardiography; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis*; D011379:Prognosis