title: Out of synch: Clock mutation causes obesity in mice.
abstract: The Clock gene encodes an essential component of the "master clock" driving circadian rhythm in the hypothalamic suprachiasmatic nucleus (SCN). New evidence that Clock mutant mice are hyperphagic and obese suggests a previously unrecognized link between molecular controls of circadian rhythm and energy homeostasis.
authors.affiliation: Department of Medicine, Harborview Medical Center, and University of Washington, Seattle, Washington 98104, USA.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Williams
authors.forename: Michael W
authors.initials: MW
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D056926:CLOCK Proteins; D051379:Mice; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism
chemical_list: D015534:Trans-Activators; D056926:CLOCK Proteins; C538944:Clock protein, mouse