title: Aggressive basal cell carcinoma in the nasal region.
abstract: It is extremely rare for basal cell carcinoma (BCC) to metastasize, so it is often only simply excised. However, BCC may cause severe local tissue destruction, which often extends to surrounding muscle, cartilage, and bone; it is then termed "aggressive" BCC. We evaluated the safety margin and the reconstruction method in four cases of nasal BCC that were diagnosed as aggressive BCC histopathologically or by imaging, including magnetic resonance imaging (MRI) and computerized tomography (CT) and then treated by excision. The results showed that the larger the aggressive BCC was, the smaller the histopathological safety margins became. The lateral nasal region was classified into three regions, and individual reconstruction was performed according to anatomical unit, resulting in favorable outcomes. Nasal BCC should be closely examinated, it requires a careful treatment strategy similar to that for other malignant skin tumors.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Osaka City University Medical School, Osaka, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Motomura
authors.forename: Toshiko
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Teruichi
authors.initials: T
authors.lastname: Harada
authors.forename: Michinari
authors.initials: M
authors.lastname: Muraoka
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D009666:Nose; D019651:Plastic Surgery Procedures; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery*; D013524:Surgical Flaps; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome