[Creutzfeldt-Jakob disease and other human forms of transmissible spongiform encephalopathy in Italy: a mortality study carried out from different data sources].
Creutzfeldt-Jakob Disease (CJD) is a rare pathology (about 1 case per million) but it has a great importance for Public Health; the Italian National CJD register has been established in the Istituto Superiore di Sanita (ISS) since 1993, and epidemiological studies on CJD have been carried out as well. This paper reports a mortality study carried out comparing and integrating data from the two available sources: the National CJD Register and the Italian Data Base on Mortality, processed by the ISS Statistics Unit, on the data collected by the Italian Census Bureau (ISTAT). The study allowed to estimate: the underreporting of CJD mortality to both sources, the misclassification of ISTAT data and the integrated mortality rates from CJD in Italy: 1.58 per million persons aged 25 or more, average rate during the period 1993-1999.
Conti
Susanna
S
Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy. pocchia@iss.it
Masocco
Maria
M
Solimini
Renata
R
Toccaceli
Virgilia
V
Vichi
Monica
M
Ladogana
Anna
A
Almonti
Susanna
S
Puopolo
Maria
M
Pocchiari
Maurizio
M
D000047:Academies and Institutes / Q000706:statistics & numerical data; D000328:Adult; D000368:Aged; D002423:Cause of Death; D007562:Creutzfeldt-Jakob Syndrome / Q000145:classification / Q000175:diagnosis / Q000401:mortality*; D016208:Databases, Factual / Q000706:statistics & numerical data; D003951:Diagnostic Errors; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D038801:International Classification of Diseases; D007558:Italy / Q000453:epidemiology; D008297:Male; D008498:Medical Record Linkage; D008875:Middle Aged; D011159:Population Surveillance; D017096:Prion Diseases / Q000145:classification / Q000175:diagnosis / Q000401:mortality*; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies