Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.
The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.
Shi
Hong
H
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Kunming, China. sub@mail.kiz.ac.cn.
Dong
Yong-Li
YL
Wen
Bo
B
Xiao
Chun-Jie
CJ
Underhill
Peter A
PA
Shen
Pei-Dong
PD
Chakraborty
Ranajit
R
Jin
Li
L
Su
Bing
B
D041322:Chromosomes, Human, Y / Q000235:genetics*; D019143:Evolution, Molecular; D005202:Asia, Eastern; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D011157:Population Dynamics
D005819:Genetic Markers