Glucocorticosteroids in allergic inflammation: clinical benefits in allergic rhinitis, rhinosinusitis, and otitis media.
Allergic rhinitis, rhinosinusitis, and otitis media are among the most common health problems encountered in general practice. Although frequently trivialized, they affect the quality of life, represent a significant socioeconomic burden, and are associated with some serious complications. In addition, allergic rhinitis, rhinosinusitis, and otitis media are often considered as comorbidities. These disorders involve an inflammatory process of the respiratory mucosa of the nose, paranasal sinuses, or middle ear. Because of their well-known anti-inflammatory effects, the role of glucocorticosteroids in the management of these three disorders has been questioned, evaluated, and, in some cases, established.
van Cauwenberge
P
P
Department of Otorhinolaryngology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium. paul.vancauwenberge@urgent.be
Van Hoecke
H
H
Vandenbulcke
L
L
Van Zele
T
T
Bachert
C
C
D000281:Administration, Intranasal; D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy*; D007273:Injections, Intramuscular; D009298:Nasal Polyps / Q000188:drug therapy; D010034:Otitis Media with Effusion / Q000188:drug therapy; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy; D012852:Sinusitis / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids