title: Application of three-dimensional magnetic resonance image registration for monitoring hip joint diseases.
abstract: The purpose of this study was to estimate the accuracy of a method in which three-dimensional (3D) magnetic resonance (MR) volume registration is used for monitoring hip joint disease. Data were analyzed using a normalized cross-correlation (NCC) algorithm involving a user-selected 3D box including the proximal femur. Most of the femoral head was not included in the 3D box because it can become deformed during the course of disease. The accuracy of registration around the femoral head was evaluated using five phantoms and clinical MR data of 17 patients with hip joint disease. In the phantom experiment, registration accuracy was evaluated using four fiducial markers attached to the femoral head. In the experiment using clinical data, registration accuracy was evaluated using a landmark in the femoral head. The registration accuracy in the phantom and clinical experiment was 0.43+/-0.18 mm (S.D.) and 1.12+/-0.46 mm (S.D.), respectively. The former is a value less than half the minimum dimension of a voxel (1.25 x 1.25 x 1.0 mm). Although the latter is slightly larger than the minimum dimension of a voxel, actual errors would be smaller because of the uncertainty in landmark localization. In conclusion, the present method based on an NCC algorithm can be used to accurately register serial MR images of the femoral heads with an error on the order of a voxel. We believe that this method is sufficiently accurate for monitoring hip joint diseases.
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. masaki-tko@umin.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Takao
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Sugano
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishii
authors.forename: Hisahi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Jun
authors.initials: J
authors.lastname: Masumoto
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Miki
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Sato
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tamura
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D018450:Disease Progression; D005270:Femur Head / Q000473:pathology*; D006621:Hip Joint; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007592:Joint Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging