title: Stilbenophane analogues of deoxycombretastatin A-4.
abstract: A new family of polyoxygenated stilbenophanes has been synthesized as conformationally restricted analogues of antimitotic combretastatins. By means of the McMurry olefination process, compounds derived from diethyleneglycol and 1,6-hexanediol were obtained, whereas Grubbs' catalyst failed in producing the ring-closing metathesis to this kind of macrocyclic products.
authors.affiliation: Laboratorio de Química Orgánica y Farmacéutica, Universidad de Salamanca, Facultad de Farmacia, Campus Miguel de Unamuno, E-37007, Salamanca, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Mateo
authors.forename: Concepción
authors.initials: C
authors.lastname: Pérez-Melero
authors.forename: Rafael
authors.initials: R
authors.lastname: Peláez
authors.forename: Manuel
authors.initials: M
authors.lastname: Medarde
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; C504774:stilbenophane; C058728:fosbretabulin