"Acute myelogenous leukemia like" translocations in CML blast crisis: two new cases of inv(16)/t(16;16) and a review of the literature.
We describe two patients with CML blast crisis with clonal evolution affecting 16q22 (t(16;16)(p13;q22) and inv(16)(p13;q22), abnormalities of core binding factor, usually found in de novo acute myeloid leukemia (AML)). The bone marrow of both cases showed myelomonocytic (M4) differentiation and eosinophilia. Both patients had prominent extramedullary disease and had poor response to treatment. A literature search focused on patients with CML and additional chromosome changes more typical of AML, revealed that the morphology of the blasts correlated with the finding typical of the underlying "AML" cytogenetic abnormality and an overall very poor clinical outcome, even in the groups with "favorable" AML type translocations.
Patel
Bhaumik B
BB
Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Internal Medicine, Division of Hematology-Oncology, Karmanos Cancer Institute, 4HW-4238, 4100 John R, Detroit, MI 48201, USA.
Mohamed
Anwar N
AN
Schiffer
Charles A
CA
D001752:Blast Crisis / Q000235:genetics*; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged