title: The effects of BIS-GMA and TEG-DMA on female mouse fertility.
abstract: OBJECTIVE
  The current study evaluated the effect of bisphenol A glycerolate dimethacrylate (BIS-GMA) and triethyleneglycol dimethacrylate (TEG-DMA) on female mouse fertility.
  
  
  METHODS
  Adult female mice were exposed to BIS-GMA or TEG-DMA (0, 25 and 100 microg/kg) intragastrically daily for 28 d and then mated with sexually mature untreated male mice and after mating their fertility was assessed.
  
  
  RESULTS
  In females exposed to BIS-GMA at both doses significant increases in the total number of resorptions out of the total number of implantations were observed, with a significant increase in the number of animals with resorptions at the higher dose. Significant reductions in body weights and significant increases in ovary weights were also observed. Exposure to TEG-DMA at a dose of 100 microg/kg resulted in significant reductions in pregnancy rates and a significant increase in the total number of embryonal resorptions. Significant reductions in body and uterine weights were also observed in females exposed to TEG-DMA.
  
  
  CONCLUSIONS
  The results suggest that both BIS-GMA and TEG-DMA have reproductive toxic effects in female mice.
authors.affiliation: Department of Applied Biology, Faculty of Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. darmani@just.edu.jo
authors.forename: Homa
authors.initials: H
authors.lastname: Darmani
authors.forename: Ahmad S
authors.initials: AS
authors.lastname: Al-Hiyasat
mesh_terms: D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D003188:Composite Resins / Q000009:adverse effects*; D003764:Dental Materials / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011109:Polymethacrylic Acids / Q000009:adverse effects*; D011247:Pregnancy / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
chemical_list: D003188:Composite Resins; D003764:Dental Materials; D011109:Polymethacrylic Acids; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate