Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive and motor impairment.
Cognitive and motor deficits have been proposed as markers of abnormal neurodevelopment in schizophrenia and have been associated with genetic liability. In a multicenter study involving 106 subjects, 56 with deficit schizophrenia and 50 with nondeficit schizophrenia, we tested the hypothesis that the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism is associated with cognitive and motor deficits either in schizophrenia as a whole or in its deficit subtype. The COMT Val(158)Met polymorphism shared 6.6% of the executive/attention dysfunction variance in patients with schizophrenia and 15.6% of the motor impairment variance in patients with deficit schizophrenia. These results support the hypothesis that the COMT Val(158)Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only.
Galderisi
Silvana
S
Department of Psychiatry, University of Naples SUN, Naples, Italy. sgalderi@tin.it
Maj
Mario
M
Kirkpatrick
Brian
B
Piccardi
Paola
P
Mucci
Armida
A
Invernizzi
Giordano
G
Rossi
Alessandro
A
Pini
Stefano
S
Vita
Antonio
A
Cassano
Paolo
P
Stratta
Paolo
P
Severino
Giovanni
G
Del Zompo
Maria
M
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000150:complications*; D016001:Confidence Intervals; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics*; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000150:complications*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D012565:Schizophrenic Psychology; D014633:Valine / Q000235:genetics*
D012333:RNA, Messenger; D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine