title: Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis.
abstract: OBJECTIVE
  We aimed to evaluate antioxidant paraoxonase 1 activity together with malondialdehyde (MDA) (an oxidative stress parameter) levels in patients with rheumatoid arthritis.
  
  
  METHODS
  Fifty-seven rheumatoid arthritis patients were included in the study and subgrouped according to disease activity (active, n = 31; inactive, n = 26) and compared with healthy controls (n = 25). Serum paraoxonase 1 activity and MDA levels were measured according to an enzymatic spectrophotometric method.
  
  
  RESULTS
  Serum MDA level was higher (P = 0.001) whereas paraoxonase 1 activity was lower (P = 0.001) in the patient group than the controls. When active and inactive subgroups were compared with the control group, there was a statistically significant difference between each parameter. Serum MDA levels were significantly higher, while paraoxonase 1 activity was lower in the active and inactive rheumatoid arthritis groups than the control group. But there was not any difference between active and inactive patients with RA. There was a negative correlation between MDA levels and paraoxonase 1 activity.
  
  
  CONCLUSIONS
  Increased reactive oxygen species levels in rheumatoid arthritis may result in a pro-oxidation environment, which in turn could result in decreased antioxidant paraoxonase 1 activity and increased MDA levels.
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Turkey. gbaskol@yahoo.com
authors.forename: Gulden
authors.initials: G
authors.lastname: Baskol
authors.forename: Huseyin
authors.initials: H
authors.lastname: Demir
authors.forename: Mevlut
authors.initials: M
authors.lastname: Baskol
authors.forename: Eser
authors.initials: E
authors.lastname: Kilic
authors.forename: Filiz
authors.initials: F
authors.lastname: Ates
authors.forename: Derya
authors.initials: D
authors.lastname: Kocer
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Muhtaroglu
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood*; D043303:Aryldialkylphosphatase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000097:blood
chemical_list: D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D043303:Aryldialkylphosphatase