title: Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy.
abstract: Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients.
authors.affiliation: Department of Molecular Immunology, Belozersky Institute of Physico-Chemical Biology, Moscow State University, Vorobjovy Gory, Moscow 119899, Russia.
authors.forename: Yuriy V
authors.initials: YV
authors.lastname: Shebzukhov
authors.forename: Ekaterina P
authors.initials: EP
authors.lastname: Koroleva
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Khlgatian
authors.forename: Maria A
authors.initials: MA
authors.lastname: Lagarkova
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Meshcheryakov
authors.forename: Mikhail R
authors.initials: MR
authors.lastname: Lichinitser
authors.forename: Julia
authors.initials: J
authors.lastname: Karbach
authors.forename: Elke
authors.initials: E
authors.lastname: Jager
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Kuprash
authors.forename: Sergei A
authors.initials: SA
authors.lastname: Nedospasov
mesh_terms: D000906:Antibodies / Q000097:blood* / Q000276:immunology; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D014408:Biomarkers, Tumor / Q000097:blood* / Q000276:immunology; D003110:Colonic Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D013940:Thymidylate Synthase / Q000276:immunology*; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000906:Antibodies; D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; D013940:Thymidylate Synthase; D005472:Fluorouracil