Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in Germany.
A total of 486 Streptococcus pneumoniae isolates were collected in 2003 and 2004 in Germany and revealed the following resistance rates: penicillin G (7.2%) and erythromycin A (18.9%). Telithromycin exhibited good in vitro activity (MIC at which 90% of the isolates tested were inhibited, 0.125 microg/ml). However, one erm(B)-positive isolate was found to be telithromycin resistant (MIC, 8 microg/ml).
Reinert
Ralf René
RR
Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, D-52057 Aachen, Germany. Reinert@rwth-aachen.de
van der Linden
Mark
M
Al-Lahham
Adnan
A
D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D018942:Macrolides / Q000494:pharmacology; D008565:Membrane Proteins / Q000235:genetics; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D011018:Pneumonia, Pneumococcal / Q000453:epidemiology* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D048628:Ketolides; D018942:Macrolides; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D004917:Erythromycin; C106791:telithromycin