Monocyte chemoattractant protein-1 level in serum of patients with acute spinal cord injury.
OBJECTIVE
To detect the concentration of monocyte chemoattractant protein-1 (MCP-1) in the serum of patients with incomplete spinal cord injury and evaluate its relation with the pathologic classification of the spinal cord injury.


METHODS
MCP-1 concentration in the serum of patients with incomplete spinal cord injury (iSCI), single spine compression and healthy subjects were detected by ELISA, respectively in the present study and the magnetic resonance imaging data of these patients were studied at the same time on a blind base.


RESULTS
Serum level of MCP-1 in iSCI patients was 428 pg/ml +/- 11 pg/ml by ELISA, which was higher than both that of the patients with single spine compression and of controls, with the concentration of 184 pg/ml +/- 21 pg/ml and 124 pg/ml +/- 15 pg/ml, respectively. There was significant difference between any two groups (P < 0.01). iSCI patients with normal MRI showed a lower serum level of MCP-1 as 312 pg/ml+/- 30 pg/ml. Pathological classification of spinal cord edema and hematoma corresponded to 390 pg/ml +/- 16 pg/ml and 508 pg/ml+/- 24 pg/ml in the concentration of MCP-1.


CONCLUSIONS
MCP-1 may induce secondary inflammatory response by recruiting inflammatory cells to the injury site and thus affect the prognosis of spinal cord injury.
Liu
Shi-qing
SQ
Deparment of Orthopaedics of Renmin Hospital, Wuhan University, China. martin1354@163.com
Ma
Yong-gang
YG
Peng
Hao
H
Fan
Li
L
D000208:Acute Disease; D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000097:blood* / Q000473:pathology
D018932:Chemokine CCL2