title: Role for mannose binding lectin in the prevention of Mycoplasma infection.
abstract: Polymorphisms in exon 1 of the MBL-2 gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P = 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P = 0.0087). The lectin was shown to bind to three strains of mycoplasma.
authors.affiliation: MW Turner, Immunobiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.
authors.forename: Renata M J
authors.initials: RM
authors.lastname: Hamvas
authors.forename: Marina
authors.initials: M
authors.lastname: Johnson
authors.forename: Arine M
authors.initials: AM
authors.lastname: Vlieger
authors.forename: Clare
authors.initials: C
authors.lastname: Ling
authors.forename: Andrea
authors.initials: A
authors.lastname: Sherriff
authors.forename: Angela
authors.initials: A
authors.lastname: Wade
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Klein
authors.forename: Malcolm W
authors.initials: MW
authors.lastname: Turner
authors.forename: A David B
authors.initials: AD
authors.lastname: Webster
mesh_terms: D005434:Flow Cytometry; D006801:Humans; D037601:Mannose-Binding Lectin / Q000378:metabolism*; D009174:Mycoplasma / Q000378:metabolism; D009175:Mycoplasma Infections / Q000378:metabolism*
chemical_list: D037601:Mannose-Binding Lectin