title: Osseous metastasis of pineoblastoma: a case report and review of the literature.
abstract: OBJECTIVE
  To review the literature on the occurrence of osseous metastases in recurrent pineoblastoma, and to report upon the feasibility and efficacy of treatment using intensive conventional chemotherapy to achieve a remission, followed by consolidation with marrow ablative chemotherapy and autologous hemopoietic stem cell rescue.
  
  
  METHODS
  An adult with isolated extraneural, osseous and bone marrow metastases from a pineoblastoma, received conventional cyclical chemotherapy, followed by consolidation with marrow ablative chemotherapy (thiotepa, carboplatin and temozolomide) and autologous hemopoietic stem cell rescue.
  
  
  RESULTS
  A complete radiographic and histopathologic response was achieved after almost one year of conventional chemotherapy that was tolerated without significant sequelae. Following successful harvesting of peripheral blood stem cells, the patient underwent myeloablative chemotherapy with autologous stem cell rescue, without difficulty in hemopoietic reconstitution and without serious or permanent side effects.
  
  
  CONCLUSIONS
  Osseous metastases from pineoblastoma are an extremely rare occurrence. We conclude that conventional chemotherapy can achieve a complete response, and subsequent consolidation with marrow ablative chemotherapy and autologous hemopoietic stem cell rescue is feasible and well tolerated.
authors.affiliation: Department of Pediatrics, New York University of School of Medicine, New York, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Constantine
authors.forename: Douglas C
authors.initials: DC
authors.lastname: Miller
authors.forename: Sharon
authors.initials: S
authors.lastname: Gardner
authors.forename: Casilda
authors.initials: C
authors.lastname: Balmaceda
authors.forename: Jonathan
authors.initials: J
authors.lastname: Finlay
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D019046:Bone Marrow Neoplasms / Q000556:secondary* / Q000628:therapy; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D018237:Germinoma / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D010870:Pineal Gland / Q000473:pathology*; D010871:Pinealoma / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome