Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists.
5-Nitrobenzimidazole derivatives with varying substituents at 2-position have been designed, synthesized, and evaluated for angiotensin II antagonistic activity. A drug-receptor interaction model has been proposed.
Bali
Alka
A
University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh, India.
Bansal
Yogita
Y
Sugumaran
M
M
Saggu
Jatinder Singh
JS
Balakumar
P
P
Kaur
Gurpreet
G
Bansal
Gulshan
G
Sharma
Ajay
A
Singh
Manjeet
M
D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D008958:Models, Molecular; D011485:Protein Binding; D013329:Structure-Activity Relationship
D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles