title: Demographics of HIV-1 infection in Denmark: results from the Danish HIV Cohort Study.
abstract: We used a population-based cohort study design to describe the demographic characteristics of the HIV-infected population in Denmark and their variation over time. HIV treatment in Denmark is restricted to 9 centres, and all 3941 HIV-1 infected patients more than 15 y old seen at these centres in 1995-2003 were included. We found an estimated HIV prevalence of 70 per 100,000, and a mean annual incidence rate of 5.1 per 100,000 persons. The number of newly infected individuals was stable with a median of 231 per y (period 1995-2002), whereas the number of deaths decreased from 166 in 1995 to 50 in 2000 (p=0.000) and remained stable thereafter. Of the enrolled patients, 75% were males, 80% were Caucasian, 13% were black African, and the primary risk behaviour was male-to-male sexual contact (44%), heterosexual contact (36%), and injection drug use (11%). During the y 1995-2003 we found an increase in age at diagnosis (p=0.000), and no major changes in gender, race, mode of infection, or baseline CD4+ cell count and viral load, neither overall not within subgroups of patients. In this period 14.5% had AIDS at the time of HIV diagnosis. Our data do not confirm concerns about unmonitored evolution in the HIV epidemic in Denmark.
authors.affiliation: Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark. nicolai.lohse@ouh.fyns-amt.dk
authors.forename: Nicolai
authors.initials: N
authors.lastname: Lohse
authors.forename: Ann-Brit Eg
authors.initials: AB
authors.lastname: Hansen
authors.forename: Søren
authors.initials: S
authors.lastname: Jensen-Fangel
authors.forename: Gitte
authors.initials: G
authors.lastname: Kronborg
authors.forename: Birgit
authors.initials: B
authors.lastname: Kvinesdal
authors.forename: Court
authors.initials: C
authors.lastname: Pedersen
authors.forename: Carsten S
authors.initials: CS
authors.lastname: Larsen
authors.forename: Axel
authors.initials: A
authors.lastname: Møller
authors.forename: Lars
authors.initials: L
authors.lastname: Willumsen
authors.forename: Niels
authors.initials: N
authors.lastname: Obel
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D003710:Demography; D003718:Denmark / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000208:ethnology / Q000635:transmission; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D012307:Risk Factors; D019562:Viral Load
chemical_list: D012367:RNA, Viral