Highly regio-, chemo- and diastereoselective synthesis of oxa-bridged spirocycles: a novel observation of reverse selectivity.
The reverse regio- and diastereoselectivities are observed between the reactions involving 5- and 6-membered-ring cyclic carbonyl ylide dipoles with alpha-methylene ketones. A mild catalytic route to synthesize spirocyclic systems with high regio-, chemo- and diastereoselectivities is described.
Muthusamy
Sengodagounder
S
Central Salt and Marine Chemicals Research Institute (CSIR), Bhavnagar 364 002, India. muthu@csmcri.org
Krishnamurthi
Janagiraman
J
Nethaji
Munirathnam
M