title: Frigocyclinone, a novel angucyclinone antibiotic produced by a Streptomyces griseus strain from Antarctica.
abstract: A new angucyclinone antibiotic, frigocyclinone, was isolated from Streptomyces griseus strain NTK 97, consisting of a tetrangomycin moiety attached through a C-glycosidic linkage with the aminodeoxysugar ossamine. Frigocyclinone showed antibacterial activities against Gram-positive bacteria.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, au der Morgenstelle 28, D-72076 Tübingen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Bruntner
authors.forename: Tatiana
authors.initials: T
authors.lastname: Binder
authors.forename: Wasu
authors.initials: W
authors.lastname: Pathom-aree
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bull
authors.forename: Olivier
authors.initials: O
authors.lastname: Potterat
authors.forename: Carsten
authors.initials: C
authors.lastname: Puder
authors.forename: Stefan
authors.initials: S
authors.lastname: Hörer
authors.forename: Angela
authors.initials: A
authors.lastname: Schmid
authors.forename: Walter
authors.initials: W
authors.lastname: Bolek
authors.forename: Klaus
authors.initials: K
authors.lastname: Wagner
authors.forename: Gerhard
authors.initials: G
authors.lastname: Mihm
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000864:Antarctic Regions; D000880:Anthraquinones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D013056:Spectrophotometry, Ultraviolet; D013305:Streptomyces griseus / Q000378:metabolism*
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C502980:frigocyclinone