Suppressive effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant on ethanol-induced gastric mucosal injury in rats.
Ethanol has been found to induce ulcerative gastric lesion in humans. The present study investigated the in vivo protective effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant against ethanol-induced gastric mucosal injury in rats. The rats were treated with 80% ethanol for 3 d after pretreatment with two doses of astaxanthin (5 and 25 mg/kg of body weight respectively) for 3 d, while the control rats received only 80% ethanol for 3 d. The oral administration of astaxanthin (5 and 25 mg/kg of body weight) showed significant protection against ethanol-induced gastric lesion and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment with astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin.
Kim
Jeong-Hwan
JH
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, South Korea.
Choi
Seok-Keun
SK
Choi
Sang-Yun
SY
Kim
Han-Kyeom
HK
Chang
Hyo-Ihl
HI
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry* / Q000235:genetics; D002374:Catalase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D013482:Superoxide Dismutase / Q000378:metabolism; D024341:Xanthophylls; D019207:beta Carotene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D024341:Xanthophylls; D019207:beta Carotene; D000431:Ethanol; D008315:Malondialdehyde; C005948:astaxanthine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase