title: In vitro release of clomipramine HCl and buprenorphine HCl from poly adipic anhydride (PAA) and poly trimethylene carbonate (PTMC) blends.
abstract: Controlled drug-delivery technology is concerned with the systematic release of a pharmaceutical agent to maintain a therapeutic level of the drug in the body for modulated and/or prolonged periods of time. This may be achieved by incorporating the therapeutic agent into a degradable polymer vehicle, which releases the agent continuously as the matrix erodes. In this study, poly trimethylene carbonate (PTMC), an aliphatic polycarbonate, and poly adipic anhydride (PAA), an aliphatic polyanhydride, were synthesized via melt condensation and ring-opening polymerization of trimethylene carbonate and adipic acid, respectively. The release of clomipramine HCl and buprenorphine HCl from discs prepared with the use of PTMC-PAA blends in phosphate buffer (pH 7.4) are also described. Clomipramine HCl and buprenorphine HCl were both used as hydrophilic drug models. Theoretical treatment of the data with the Peppas model revealed that release of clomipramine HCl (5%) in devices containing 70% PTMC or more followed a Fickian diffusion model. However, the releases of buprenorphine HCl (5%) in the same devices were anomalous. For devices containing 50% and more PAA, surface erosion may play a significant role in the release of both molecules.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P. O. Box 14155-6451, Tehran, Iran. dinarvand@sina.tums.ac.ir
authors.forename: Rassoul
authors.initials: R
authors.lastname: Dinarvand
authors.forename: Mohammed Massoud
authors.initials: MM
authors.lastname: Alimorad
authors.forename: Massoud
authors.initials: M
authors.lastname: Amanlou
authors.forename: Hamid
authors.initials: H
authors.lastname: Akbari
mesh_terms: D000272:Adipates / Q000737:chemistry*; D000701:Analgesics, Opioid / Q000493:pharmacokinetics; D000812:Anhydrides / Q000737:chemistry*; D000929:Antidepressive Agents, Tricyclic / Q000493:pharmacokinetics*; D002047:Buprenorphine / Q000493:pharmacokinetics; D002997:Clomipramine / Q000493:pharmacokinetics*; D004058:Diffusion; D004146:Dioxanes / Q000737:chemistry*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D011076:Polycarboxylate Cement / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012044:Regression Analysis; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors
chemical_list: D000272:Adipates; D000701:Analgesics, Opioid; D000812:Anhydrides; D000929:Antidepressive Agents, Tricyclic; D004146:Dioxanes; D011076:Polycarboxylate Cement; D011108:Polymers; C504784:poly adipic anhydride; C005506:polycarbonate; C059299:polytrimethylene carbonate; D002047:Buprenorphine; C029900:adipic acid; D002997:Clomipramine