Downregulation of the major histocompatibility complex class I molecules by human herpesvirus type 8 and impaired natural killer cell activity in primary effusion lymphoma development.
Primary effusion lymphomas (PELs) are invariably infected by human herpesvirus type 8 (HHV8) and often co-infected by Epstein-Barr virus (EBV). We found that expression of major histocompatibility complex class I (MHC-I) surface molecules was significantly decreased in PEL cells when compared with HHV8 negative lymphomas, irrespective of EBV infection. MHC-I downregulation rendered PEL cells sensitive to recognition and killing by natural killer (NK) cells. Intriguingly, analysis of MHC-I non-restricted cytotoxicity in two PEL patients indicated a reduced NK cell activity when compared with healthy individuals. These data suggest that PEL outgrowth may require an impaired NK cell function.
Sirianni
Maria Caterina
MC
Clinical Immunology, Department of Clinical Medicine, University of Roma La Sapienza, Italy. mariacaterina.sirianni@uniroma1.it
Libi
Fabio
F
Campagna
Massimo
M
Rossi
Davide
D
Capello
Daniela
D
Sciaranghella
Gaia
G
Carbone
Antonio
A
Simonelli
Cecilia
C
Monini
Paolo
P
Gaidano
Gianluca
G
Ensoli
Barbara
B
D001402:B-Lymphocytes / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D003601:Cytotoxicity Tests, Immunologic; D004279:DNA, Viral / Q000032:analysis; D015536:Down-Regulation; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000276:immunology; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000821:virology*; D012698:Serologic Tests
D015415:Biomarkers; D004279:DNA, Viral; D015395:Histocompatibility Antigens Class I