title: The safety and accuracy of sentinel-node biopsy in early-stage invasive breast cancer--Turkish experience.
abstract: The purpose of this prospective study was to investigate the correlation of sentinel lymph node (SLN) and axillary lymph node (ALN) metastasis in early-stage invasive breast cancer in a single institution. One hundred and fifteen patients with early-stage invasive breast cancer first underwent SLND followed by an appropriate surgical procedure (modified radical mastectomy, lumpectomy + axillary dissection, simple mastectomy + mammoplasty). In this series, a radioactive agent (technetium) was used to investigate the sentinel lymph node/nodes. In 28 (24.3%) patients, metastases were found in both SLN and axillary dissections. There were no metastases in either of these procedures in 69 (60%) patients. SLN metastasis was found in 13 (11.3%) patients, but no axillary metastasis was found. No skip metastasis was detected. Five patients in whom the sentinel node was not found were also negative for axillary metastasis. As the studies progress in this direction, it might be possible to avoid axillary dissection in patients with early breast cancer in whom metastasis in SLN cannot be detected. We believe this will reduce morbidity from breast cancer surgeries.
authors.affiliation: General Surgery Department, Sişli Etfal Training and Research Hospital, Istanbul, Turkey. abutkebudi@yahoo.com
authors.forename: Abut
authors.initials: A
authors.lastname: Kebudi
authors.forename: Adnan
authors.initials: A
authors.lastname: Işgör
authors.forename: Murat
authors.initials: M
authors.lastname: Atay
authors.forename: Gürkan
authors.initials: G
authors.lastname: Yetkin
authors.forename: Dehan
authors.initials: D
authors.lastname: Yazici
authors.forename: Aygün
authors.initials: A
authors.lastname: Yildiz
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D013667:Technetium; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium