A convenient method for synthesis of cyclic peptide libraries.
Cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. Owing to the robustness of amide bond chemistry, the ability to explore extensive chemical diversity by incorporation of unnatural and natural amino acids, and the ability to explore conformational diversity, through the incorporation of various constraints, arrays of cyclic peptides can be tailored to broadly sample chemical diversity. We describe the combination of a safety catch linker with a directed-sorted procedure for the synthesis of large arrays of diverse cyclic peptides for high-throughput screening.
Bourne
Gregory T
GT
Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia.
Nielson
Jonathon L
JL
Coughlan
Justin F
JF
Darwen
Paul
P
Campitelli
Marc R
MR
Horton
Douglas A
DA
Rhümann
Andreas
A
Love
Stephen G
SG
Tran
Tran T
TT
Smythe
Mark L
ML
D000596:Amino Acids / Q000737:chemistry; D001331:Automation; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D019151:Peptide Library; D010456:Peptides, Cyclic