[Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men].
OBJECTIVE
To identify single nucleotide polymorphisms (SNP) of the angiotensin II type 2 receptor (AGTR2) gene, and to determine whether the AGTR2 polymorphisms are associated with essential hypertension in a male Chinese population.


METHODS
Direct DNA sequencing was performed in 20 subjects. 96 male hypertensive patients and 107 normal controls were included to assess the contribution of the SNP of AGTR2 gene to hypertension.


RESULTS
Seven SNP of the AGTR2 gene were identified, of which 4 were reported for the first time. A case-control study including two polymorphisms (A1675G and T1334C) showed a significant increase in the A1675 allele frequency among male hypertensive subjects as compared with normotensive subjects (49.0% vs 34.6%, P < 0.05).


CONCLUSIONS
The AGTR2 A1675G polymorphism might be involved in the development of essential hypertension in male Chinese.
Qiao
Wei-wei
WW
Shandong Provincial Hospital, Clinical Medical College of Shandong University, Jinan 250021, China.
Zhang
Kui-xing
KX
Liu
Tong-bao
TB
Liu
Guo-xiang
GX
Xu
Shi-jie
SJ
D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*
D044139:Receptor, Angiotensin, Type 2