Long-lasting enhancement of corticostriatal transmission by taurine: role of dopamine and acetylcholine.
1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLE(TAU). 2. The occurrence of LLE(TAU) was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors. 3. LLE(TAU) was prevented by scopolamine, a muscarinic antagonist, and significantly suppressed by the nicotinic antagonist mecamylamine. 4. Thus, dopaminergic and cholinergic mechanisms, in concert with the taurine transporter and glycine receptors, contribute critically to the induction of corticostriatal LLE(TAU).
Chepkova
A N
AN
Department of Neurophysiology, Heinrich-Heine-Universität, Düsseldorf, Germany.
Sergeeva
O A
OA
Haas
H L
HL
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009434:Neural Pathways; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*; D013654:Taurine / Q000494:pharmacology*
D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013654:Taurine; D017868:Cyclic AMP-Dependent Protein Kinases; D000109:Acetylcholine; D004298:Dopamine