The effects of BIS-GMA and TEG-DMA on female mouse fertility.
OBJECTIVE
The current study evaluated the effect of bisphenol A glycerolate dimethacrylate (BIS-GMA) and triethyleneglycol dimethacrylate (TEG-DMA) on female mouse fertility.


METHODS
Adult female mice were exposed to BIS-GMA or TEG-DMA (0, 25 and 100 microg/kg) intragastrically daily for 28 d and then mated with sexually mature untreated male mice and after mating their fertility was assessed.


RESULTS
In females exposed to BIS-GMA at both doses significant increases in the total number of resorptions out of the total number of implantations were observed, with a significant increase in the number of animals with resorptions at the higher dose. Significant reductions in body weights and significant increases in ovary weights were also observed. Exposure to TEG-DMA at a dose of 100 microg/kg resulted in significant reductions in pregnancy rates and a significant increase in the total number of embryonal resorptions. Significant reductions in body and uterine weights were also observed in females exposed to TEG-DMA.


CONCLUSIONS
The results suggest that both BIS-GMA and TEG-DMA have reproductive toxic effects in female mice.
Darmani
Homa
H
Department of Applied Biology, Faculty of Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. darmani@just.edu.jo
Al-Hiyasat
Ahmad S
AS
D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D003188:Composite Resins / Q000009:adverse effects*; D003764:Dental Materials / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011109:Polymethacrylic Acids / Q000009:adverse effects*; D011247:Pregnancy / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D003188:Composite Resins; D003764:Dental Materials; D011109:Polymethacrylic Acids; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate