Suicide prevention by lithium SUPLI--challenges of a multi-center prospective study.
Several studies have shown that there is a significantly increased risk of suicide related mortality in patients with a positive history of suicide attempts. The SUPLI-Study is the first prospective, randomized, double blind, placebo controlled multi-center trial focusing on the proposed suicide preventive effects of lithium in patients with suicidal behavior but not suffering from bipolar disorder or recurrent major depressive disorder. Patients with a recent history of a suicide attempt are treated with lithium versus placebo during a 12 month period. The hypothesis is that lithium treatment will lead to a 50% reduction of suicidal behavior. The protocol of the study and preliminary results are presented.
Lauterbach
Erik
E
Department of Psychiatry and Psychotherapy, Universitätsklinikum Schleswig-Holstein, Luebeck, Germany. lauterbach.e@psychiatry.uni-luebeck.de
Ahrens
Bernd
B
Felber
Werner
W
Oerlinghausen
Bruno Muller
BM
Kilb
Birgit
B
Bischof
Gerd
G
Heuser
Isabella
I
Werner
Petra
P
Hawellek
Barbara
B
Maier
Wolfgang
W
Lewitzka
Ute
U
Pogarell
Oliver
O
Hegerl
Ulrich
U
Bronisch
Thomas
T
Richter
Kneginja
K
Niklewski
Günther
G
Broocks
Andreas
A
Hohagen
Fritz
F
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use*; D011446:Prospective Studies; D000092864:Suicide Prevention
D014150:Antipsychotic Agents; D016651:Lithium Carbonate