title: Effects of lidocaine with and without epinephrine on plasma epinephrine and lidocaine concentrations and hemodynamic values during third molar surgery.
abstract: Lidocaine with epinephrine is currently the most common local anesthetic agent used for impacted third molar surgery. The purpose of the present study was to define the adverse hemodynamic effects and plasma concentrations of lidocaine and epinephrine on 17 healthy patients during the impacted teeth operations. Arterial blood pressure (systolic blood pressure, diastolic blood pressure), heart rate, peripheral oxygen saturation range, and electrocardiography were measured by an automatic noninvasive pressure device and monitor. High-performance liquid chromatography was used to measure the changes of plasma concentrations of epinephrine and lidocaine from blood samples taken 5 different times during the operation. We concluded that lidocaine-epinephrine is effective local anesthetic and had no important adverse events in healthy patients during the third molar surgery.
authors.affiliation: Department of Oral Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. dmeral@hacettepe.edu.tr
authors.forename: Gokce
authors.initials: G
authors.lastname: Meral
authors.forename: Ferda
authors.initials: F
authors.lastname: Tasar
authors.forename: Filiz
authors.initials: F
authors.lastname: Sayin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Saysel
authors.forename: Sedef
authors.initials: S
authors.lastname: Kir
authors.forename: Erdem
authors.initials: E
authors.lastname: Karabulut
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004562:Electrocardiography; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008964:Molar, Third / Q000601:surgery; D010100:Oxygen / Q000097:blood; D018709:Statistics, Nonparametric; D014081:Tooth Extraction; D014662:Vasoconstrictor Agents / Q000097:blood / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D008012:Lidocaine; D010100:Oxygen; D004837:Epinephrine