title: [Study of changes in the enzyme-salt composition affecting the permeability of ocular tissues under infrasound phonophoresis].
abstract: This paper deals with the study of infrasound phonophoresis-induced changes in biochemical factors, which affect the permeability of eyeball tissues. During 10 days, the rabbit right eye was exposed to an infrasound in the changing pressure mode at 4 Hz and 173 dB for 10 minutes every day. The left eye remained control. After finishing a series of studies, the animals were slaughtered, the eyes were enucleated and prepared into individual tissues. Changes in sodium-potassium composition were investigated in the first series. By causing a reduction in the cellular content of K+, infrasound exposure was found to cause a decrease in membranous potential and activation Na-channel, as confirmed by the elevated intracellular levels of Na+. This in turn enhances ocular tissue permeability for drugs without damaging the structure of a cell membrane. Changes in the activity of the following enzymes: beta-glucosidase, cathepsin D, and hy- aluronidase. Infrasound was ascertained to enhance the activity of beta-glucosidase, which accounts for the lower levels of glucose in ocular tissues and points to the activation and acceleration of biochemical processes in the tissues. At the same time the increased concentrations of cathepsin D and hyaluronidase found in ocular tissues were responsible for a temporary reduction in the viscosity of hyaluronic acid, which promotes resolution of opacities, adhesions or scars and increased tissue permeability.
authors.forename: V V
authors.initials: VV
authors.lastname: Filatov
mesh_terms: D000818:Animals; D002402:Cathepsin D / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000528:radiation effects; D005123:Eye / Q000166:cytology / Q000378:metabolism* / Q000528:radiation effects; D006821:Hyaluronoglucosaminidase / Q000378:metabolism*; D007424:Intracellular Fluid / Q000378:metabolism; D015612:Phonophoresis / Q000379:methods*; D011188:Potassium / Q000378:metabolism*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism*; D001617:beta-Glucosidase / Q000378:metabolism*
chemical_list: D012964:Sodium; D001617:beta-Glucosidase; D006821:Hyaluronoglucosaminidase; D002402:Cathepsin D; D011188:Potassium