title: [Neurologic disease due to adenovirus infection].
abstract: The aim of this study was to assess the prevalence of adenovirusm (ADV) infections in neurological disorders. A total of 108 cerebrospinal fluid (CSF) samples from 79 encephalitis cases, 7 meningitis and 22 other neurological diseases analysed in our laboratory between 2000 and 2002 were studied. Forty nine (47.4%) belonged to immunocompromised patients. Viral genome was detected using nested polymerase chain reaction (Nested-PCR) and ADV genotypes were identified using partial gene sequence analysis of hexon gene. Adenovirus were detected in 6 of 108 (5.5%) CSF samples tested. All of these were from encephalitis cases, 6/79, representing 7.6% of them. No statistically significant differences were observed (p > 0.05) between the immunocompromised and non immunocompromised patients with ADV infection of the central nervous system. Two ADV genotypes (B1 and C) were identified. In conclusion, our results describe the role of ADV in neurologic infections in Argentina. The results contribute to the knowledge of ADV epidemiology, specially in encephalitis.
authors.affiliation: Servicio de Neurovirosis, Instituto Nacional de Enfermedades Infecciosas, ANLIS-Dr. Carlos G. Malbrán, Buenos Aires, Argentina. clema@anlis.gov.ar
authors.forename: Cristina L
authors.initials: CL
authors.lastname: Lema
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Cisterna
authors.forename: Maria Cecilia
authors.initials: MC
authors.lastname: Freire
mesh_terms: D000258:Adenovirus Infections, Human / Q000134:cerebrospinal fluid / Q000821:virology*; D000260:Adenoviruses, Human / Q000235:genetics / Q000302:isolation & purification*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020805:Central Nervous System Viral Diseases / Q000134:cerebrospinal fluid / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies