title: [Optimization study on extraction technology of the seed of Ziziphus jujuba var. spinosa by orthogonal design with multi-targets].
abstract: OBJECTIVE
  To optimize extraction technology of the seed of Ziziphus jujuba var. spinosa with the targets of the total saponin, total jujuboside A and B and total flavonoids.
  
  
  METHODS
  In the method of one-way and orthogonal tests, ethanol concentration, amount of ethanol, extraction time and extraction times were the factors in orthogonal test, and each factor with three levels.
  
  
  RESULTS
  Ethanol concentration and extraction times had significant effect on all the targets, other factors should be selected in accordance with production practice.
  
  
  CONCLUSIONS
  The best extraction technology is to extract for three times with 8 fold ethanol solution (60%), and 1.5 h each time.
authors.affiliation: Department of Chinese Pharmacy , Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
authors.forename: Xiao-liang
authors.initials: XL
authors.lastname: Wang
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Ming-xia
authors.initials: MX
authors.lastname: Chen
authors.forename: Ze-feng
authors.initials: ZF
authors.lastname: Wang
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000431:Ethanol; D047309:Flavones / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000032:analysis; D012639:Seeds / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D047309:Flavones; D012503:Saponins; D000431:Ethanol; C087808:jujuboside A