Cholesterol embolization treated with corticosteroids--two case reports.
Cholesterol embolization (CE) is a potentially serious complication associated with invasive arterial maneuvers, in which standard therapy has not been established. We experienced two cases of CE in patients with severe atherosclerosis whose renal function deteriorated within a few months after invasive arterial maneuvers. CE was confirmed either by renal biopsy (case 1) or skin biopsy (case 2). Oral administration of prednisolone at a daily dose of 30 mg (0.4 mg/kg) was effective to improve their renal function. Our observation suggests that corticosteroid therapy may be beneficial in some patients with CE.
Koga
Jun-ichiro
J
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Ohno
Masahiko
M
Okamoto
Kazuhiko
K
Nakasuga
Kazuta
K
Ito
Hiroyuki
H
Nagafuji
Koji
K
Shimono
Nobuyuki
N
Koga
Hideyuki
H
Hayashida
Akihiro
A
Arita
Takeshi
T
Maruyama
Toru
T
Kaji
Yoshikazu
Y
Harada
Mine
M
D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology; D006328:Cardiac Catheterization / Q000009:adverse effects; D017023:Coronary Angiography; D003404:Creatinine / Q000097:blood; D017700:Embolism, Cholesterol / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*
D005938:Glucocorticoids; D011239:Prednisolone; D003404:Creatinine