Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline.
There are previous reports of dilated cardiomyopathy (DCM) in recessive dystrophic epidermolysis bullosa (RDEB), a debilitating blistering skin disorder. The pathogenesis of DCM in RDEB remains uncertain, although dietary deficiency of selenium and carnitine have been implicated. A 6 year old girl with RDEB who died of DCM is reported; attention is drawn to the possible role of two potentially cardiotoxic drugs, amitriptyline and cisapride.
Taibjee
S M
SM
Department of Dermatology, Birmingham Children's Hospital, UK. saleemtaibjee@blueyonder.co.uk
Ramani
P
P
Brown
R
R
Moss
C
C
D000639:Amitriptyline / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced*; D020117:Cisapride / Q000009:adverse effects / Q000627:therapeutic use; D004820:Epidermolysis Bullosa / Q000150:complications / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000627:therapeutic use
D000929:Antidepressive Agents, Tricyclic; D017366:Serotonin Receptor Agonists; D000639:Amitriptyline; D020117:Cisapride