title: Positron emission tomography after fetal transplantation in Huntington's disease.
abstract: Huntington's disease (HD) is a progressive disorder with no known cure. We report two-year postoperative positron emission tomography (PET) data from 7 HD patients who underwent intrastriatal fetal transplantation. Patients showed widespread reductions in glucose uptake with no significant change over 2 years. Dopamine receptor binding was significantly reduced in HD striatum. D1 binding did not change significantly following transplantation, but there was a significant loss of D2 binding. These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation.
authors.affiliation: Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Furtado
authors.forename: Vesna
authors.initials: V
authors.lastname: Sossi
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Hauser
authors.forename: Ali
authors.initials: A
authors.lastname: Samii
authors.forename: Michael
authors.initials: M
authors.lastname: Schulzer
authors.forename: Colleen B
authors.initials: CB
authors.lastname: Murphy
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Freeman
authors.forename: A Jon
authors.initials: AJ
authors.lastname: Stoessl
mesh_terms: D000704:Analysis of Variance; D016332:Fetal Tissue Transplantation; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods; D011485:Protein Binding / Q000502:physiology; D011954:Receptors, Dopamine / Q000378:metabolism; D013997:Time Factors
chemical_list: D011954:Receptors, Dopamine