Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. I. Taxonomy, fermentation, isolation and biological properties.
New phenylfuropyridinones and related compounds, designated citridones A, B, B' and C, were isolated along with known CJ-16,173, from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Citridones (75 microM) potentiate the miconazole activity against Candida albicans, decreasing the IC50 value of miconazole from 14.5 nM to 3.5 to approximately 6.3 nM.
Fukuda
Takashi
T
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Yamaguchi
Yuichi
Y
Masuma
Rokuro
R
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004357:Drug Synergism; D005285:Fermentation; D005663:Furans / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000145:classification / Q000378:metabolism*; D011728:Pyridones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D005663:Furans; D011728:Pyridones; D008825:Miconazole