title: A newly discovered Fc receptor that explains IgG-isotype disparities in effector responses.
abstract: The known IgG FcRs primarily mediate inflammation by interacting with IgG1, even though IgG2 isotypes tend to be more pathogenic. A novel FcgammaR that binds IgG2 but not IgG1 has just been identified, potentially explaining differences in biological activity that are seen with various IgG isotypes.
authors.affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive 217, Rockville, Maryland 20852, USA.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bolland
mesh_terms: D000818:Animals; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D017452:Receptors, IgG / Q000235:genetics / Q000378:metabolism*
chemical_list: D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D017452:Receptors, IgG