[Vilon effect on consequences of repeated radioactive and mercuric impact in small doses].
The purpose of the study was to determine the efficacy of vilon administration in rats after reiterated exposure to ecotoxicants (mercury in concentration near to maximum allowable one and gamma-radiation in small dose). In 24 hours after repeated radioactive and mercuric impact (RMI) and for 30 consecutive days the animals reported lymphopenia. At the same time the indices of DNA leucocytes content and structure did not differ from the parameters of intact animals, this could evidence the development of adaptation reactions. Vilon administration led to the normalization of the lymphocytes number by the 30th day after repeated irradiation (contrary to the radioactive- chemical control), while the number of granulocytes in the test group was higher than that in the intact control group. Study of the survival rate in rats revealed that Vilon reduced morbidity of rats in the course of 15 months after RMI.
Ivanov
S D
SD
Khavinson
V Kh
VKh
Malinin
V V
VV
Kovan'ko
E G
EG
Iamshanov
V A
VA
Kondrat'eva
A V
AV
Morozov
V G
VG
D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000528:radiation effects; D001774:Blood Chemical Analysis; D004151:Dipeptides / Q000627:therapeutic use*; D005720:Gamma Rays; D008297:Male; D017669:Mercury Compounds / Q000633:toxicity; D020262:Mercury Poisoning, Nervous System / Q000188:drug therapy*; D009566:Nitrates / Q000633:toxicity; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats
D004151:Dipeptides; D017669:Mercury Compounds; D009566:Nitrates; D011837:Radiation-Protective Agents; C029948:mercury nitrate; C415909:lysylglutamic acid