Stilbenophane analogues of deoxycombretastatin A-4.
A new family of polyoxygenated stilbenophanes has been synthesized as conformationally restricted analogues of antimitotic combretastatins. By means of the McMurry olefination process, compounds derived from diethyleneglycol and 1,6-hexanediol were obtained, whereas Grubbs' catalyst failed in producing the ring-closing metathesis to this kind of macrocyclic products.
Mateo
Carmen
C
Laboratorio de Química Orgánica y Farmacéutica, Universidad de Salamanca, Facultad de Farmacia, Campus Miguel de Unamuno, E-37007, Salamanca, Spain.
Pérez-Melero
Concepción
C
Peláez
Rafael
R
Medarde
Manuel
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry*
D000970:Antineoplastic Agents; D013267:Stilbenes; C504774:stilbenophane; C058728:fosbretabulin