title: Molecular organization of the antifungal and anticancer drug 2-(2,4-dihydroxyphenylo)-5,6-dichlorobenzothiazole in solution and in monolayers: an effect of pH.
abstract: 2-(2,4-Dihydroxyphenylo)-5,6-dichlorobenzothiazol (dHBBT) is a new anticancer, antifungal and antibacterial drug characterised also by cytostatic and anticancer activity. The effect of pH on the molecular organization of dHBBT in monomolecular layers and in solution has been studied by electronic absorption and FT-IR spectroscopies. The analysis of the spectroscopic data suggests that at neutral and at high pH values (pH 6-8) dHBBT appears in the anionic form that prevents the formation of dimers due to the electrostatic repulsion between the molecules.
authors.affiliation: Department of Physics, Agricultural University, Lublin, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Gagoś
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Menestrina
authors.forename: Andrzej
authors.initials: A
authors.lastname: Niewiadomy
authors.forename: Wiesław I
authors.initials: WI
authors.lastname: Gruszecki
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012118:Resorcinols / Q000737:chemistry*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C506216:2-(2,4-dihydroxyphenyl)-5,6-dichlorobenzothiazole; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D012118:Resorcinols; D012996:Solutions