title: COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study.
abstract: This is the first study of a possible molecular genetic basis for schizophrenia with obsessive-compulsive disorder (OCD). We performed a case-control association study of the catechol-O-methyltransferase (COMT) Val158Met polymorphism in schizophrenia-OCD patients, OCD and healthy controls. One hundred and thirteen schizophrenia-OCD patients, 79 OCD patients and 171 control subjects were genotyped for the Val(158)Met polymorphism in the COMT gene. There was no significant difference in allele and genotype distribution of the COMT gene between schizophrenia-OCD patients and healthy controls. The low-activity Met allele and Met/Met genotype were more frequent in OCD men than in schizophrenia-OCD and control individuals. This difference, however, was not statistically significant following correction for multiple comparisons. These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-OCD.
authors.affiliation: Tirat Hacarmel Mental Health Center, Tirat Carmel, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Poyurovsky
authors.forename: Elena
authors.initials: E
authors.lastname: Michaelovsky
authors.forename: Amos
authors.initials: A
authors.lastname: Frisch
authors.forename: Gabriela
authors.initials: G
authors.lastname: Knoll
authors.forename: Ilan
authors.initials: I
authors.lastname: Amir
authors.forename: Boris
authors.initials: B
authors.lastname: Finkel
authors.forename: Feodor
authors.initials: F
authors.lastname: Buniak
authors.forename: Haggai
authors.initials: H
authors.lastname: Hermesh
authors.forename: Ronit
authors.initials: R
authors.lastname: Weizman
mesh_terms: D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008715:Methionine; D020125:Mutation, Missense; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D014633:Valine
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine