title: Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus.
abstract: Overexpression of decoy receptor (DcR) 3 protein, a recently discovered member of the tumor necrosis factor receptor superfamily, was examined in 40 esophagogastrectomy specimens containing areas of Barrett esophagus (n = 27), low-grade dysplasia (n = 27), high-grade dysplasia or carcinoma in situ (n = 22), and esophageal adenocarcinoma (EAC; n = 28) with immunohistochemical analysis. The results revealed significantly more overexpression of DcR3 in high-grade dysplasia or carcinoma in situ and EAC than in benign esophageal mucosa (both P < .0001), Barrett esophagus (both P < .001), and low-grade dysplasia (P < .01 and P = .033, respectively). Low-grade dysplasia also showed significant overexpression of DcR3 compared with benign esophagus (P < .05) but not with Barrett esophagus (P > .05). DcR3 overexpression seems to negatively correlate with the grade of EAC. Our results suggest that overexpression of DcR3 protein might aid in the diagnosis of high-grade dysplasia or carcinoma in situ and EAC and also might serve as a potential therapeutic target.
authors.affiliation: Department of Pathology, Zhengzhou University School of Medicine, Henan, China.
authors.forename: Huixiang
authors.initials: H
authors.lastname: Li
authors.forename: Lurong
authors.initials: L
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Lou
authors.forename: Ivan
authors.initials: I
authors.lastname: Ding
authors.forename: Sunghee
authors.initials: S
authors.lastname: Kim
authors.forename: Luping
authors.initials: L
authors.lastname: Wang
authors.forename: Jiaoti
authors.initials: J
authors.lastname: Huang
authors.forename: P Anthony
authors.initials: PA
authors.lastname: Di Sant'Agnese
authors.forename: Jun-Yi
authors.initials: JY
authors.lastname: Lei
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis*; D053323:Receptors, Tumor Necrosis Factor, Member 6b; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505911:TNFRSF6B protein, human