Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia.
Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARbeta, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARbeta was more frequent in adult ALL than that in childhood ALL (p=0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL (p=0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL (p=0.01).
Yang
Yang
Y
Department of Medicine, Kochi Medical School, Okoh-cho, Nankoku, Kochi 783-8505, Japan.
Takeuchi
Seisho
S
Hofmann
Wolf K
WK
Ikezoe
Takayuki
T
van Dongen
Jacques J M
JJ
Szczepański
Tomasz
T
Bartram
Claus R
CR
Yoshino
Norihide
N
Taguchi
Hirokuni
H
Koeffler
H Phillip
HP
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018899:CpG Islands; D019175:DNA Methylation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism*
D009363:Neoplasm Proteins