Microbial transformation of mestranol by Cunninghamella elegans.
The microbial transformation of an oral contraceptive, mestranol (1) by Cunninghamella elegans yielded two hydroxylated metabolites, 6beta-hydroxymestranol (2) and 6beta,12beta-dihydroxymestranol (3). Metabolite 3 was found to be a new compound. These metabolites were structurally characterized on the basis of spectroscopic techniques.
Choudhary
Muhammad Iqbal
MI
International Center for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Musharraf
Syed Ghulam
SG
Siddiqui
Zafar Ali
ZA
Khan
Naik Tameen
NT
Ali
Rahat Azhar
RA
Ur-Rahman
Atta
A
D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008656:Mestranol / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D008656:Mestranol