[Influence of exogenous supplementation with luteinizing hormone during controlled ovarian hyperstimulation on the results of IVF cycle].
OBJECTIVE
To evaluate the effect of exogenous luteinizing hormone in in vitro fertilization cycles with depot GnRH agonist and low residual LH levels.


METHODS
Prospective randomized clinical trial.


METHODS
2nd Department of Gynecology and Obstetrics, Medical Faculty and L. Pasteur University Hospital Kosice


METHODS
In the prospective randomized clinical trial the effect of exogenous LH on outcomes of assisted reproduction was evaluated. The total number of 68 in vitro fertilization cycles in normogonadotrophic women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH controlled ovarian stimulation were included. In all cycles the low residual LH level in the middle of stimulation was detected. The cycles were randomized into three groups. The first group was stimulated with pure recombinant FSH. In the second group the exogenous LH activity in the form of human menotrophin was added. And in the third group the human recombinant LH was added.


RESULTS
Better outcomes of assisted reproduction were detected in both groups with exogenous LH activity. But these results, except the dosage of FSH, were not statistically significant. The increase of pregnancy rate by more than one fifth in these both groups can be considered as clinically relevant.


CONCLUSIONS
It can not be positively proved at the base of our results that exogenous LH activity in cycles with low residual LH level can improve outcomes of assisted reproduction. It could be appropriate in the future to select women that can profit from exogenous LH activity according to other parameters not only to the LH serum level.
Toporcerová
S
S
II. Gynekologicko-pôrodnická klinika LF UPJS a FN L Pasteura, Kosice.
Hredzák
R
R
Ostró
A
A
Zdilová
V
V
Potoceková
D
D
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists; D006801:Humans; D007986:Luteinizing Hormone / Q000008:administration & dosage*; D008596:Menotropins / Q000008:administration & dosage; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy
D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone