title: Probing drug action using in vitro pharmacological profiles.
abstract: The history of structure-activity relationships in drug design represents a long search for appropriate descriptors of broad biological action at the molecular level. In this context, recent work showing that in vitro pharmacological profiles can be used as exquisite descriptors of the broad biological effects of compounds represents an important breakthrough. Generalization of the methodology could have important implications for drug discovery and development. It might also provide a novel and insightful way to study systems biology.
authors.affiliation: Cerep, 128 rue Danton, 92500 Rueil-Malmaison, France. n.froloff@cerep.com
authors.forename: Nicolas
authors.initials: N
authors.lastname: Froloff
mesh_terms: D066298:In Vitro Techniques; D015335:Molecular Probes; D010600:Pharmacology
chemical_list: D015335:Molecular Probes