[The effect of desloratadine on the TXB2 and leukotrienes levels in the nasal lavage fluid of allergic rhinitis animal model].
OBJECTIVE
To observe the thromboxane (TX)B2 and cysteinyl leukotrienes (LTs) levels in the nasal lavage fluid of allergic rhinitis model and to observe the effect of desloratadine on the mediators.


METHODS
In the positive control group, 8-12 week old male or female guinea pigs were intranasal sensitized and challenged with ovalbumin solution. The antihistamine treatment group was treated with desloratadine and the negative control group was sham-sensitized and sham-challenged. The nasal lavage fluid of each group was collected 5 hours after challenge and the levels of TXB2 and LTs in the nasal lavage fluid were measured.


RESULTS
In the positive control group, the TXB2 and LTs levels were the highest of the three groups and the desloratadine treated group had lower level (P < 0.05 and P < 0.01). The negative control showed the lowest level.


CONCLUSIONS
Our study demonstrated that in this model of allergic rhinitis, the levels of TXB2 and LTs in nasal lavage fluid increased dominantly after allergen challenge and desloratadine could inhibit the release of TXB2 and LTs, which implied that the therapeutic mechanism of desloratadine might contribute to the inhibitory effect on TXB2 and LTs production or release in allergic rhinitis subjects.
Zhao
Yu
Y
Department of Otolaryngology, Prince of Wales Hospital, Chinese University of Hongkong, Shatin, N.T, Hongkong SAR, China. zhaoyu@surgery.cuhk.edu.hk
Van Hasselt
C A
CA
Woo
Kangsang
K
Wong
Yeukoi
Y
Leung
Pingcheung
P
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D039563:Histamine H1 Antagonists, Non-Sedating / Q000494:pharmacology*; D015289:Leukotrienes / Q000032:analysis; D017336:Loratadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D017817:Nasal Lavage Fluid / Q000737:chemistry; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D013929:Thromboxane B2 / Q000032:analysis
D039563:Histamine H1 Antagonists, Non-Sedating; D015289:Leukotrienes; D013929:Thromboxane B2; D017336:Loratadine; C121345:desloratadine