title: [The relation of local immune status to efficacy of immunotherapy in patients with condyloma acuminatum].
abstract: OBJECTIVE
  To study the local immune status and its relation to immunotherapy in patients with condyloma acuminatum.
  
  
  METHODS
  Clinical efficacy of 5% imiquimod cream in treating 30 patients with condyloma acuminatum was observed. The expressions of Human Leukocyte Antigen (HLA)-DR, CD1a, CD16 and Intercellular Adhesion Molecule (ICAM)-1 were detected by immunohistochemistry in lesions of these patients before treatment.
  
  
  RESULTS
  The imiquimod cream was found to be efficacious in 20 cases after 8 weeks' treatment. Before treatment, the expressions of HLA-DR, CD1a, CD16 and ICAM-1 in the lesions of responders were significantly higher than those in the lesions of nonresponders (P<0.05).
  
  
  CONCLUSIONS
  Higher expressions of HLA-DR, CD1a, CD16 and ICAM-1 suggested that immunotherapy might have efficacy in treating condyloma acuminatum.
authors.affiliation: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Yi-zhi
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Feng-yuan
authors.initials: FY
authors.lastname: Li
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage*; D003218:Condylomata Acuminata / Q000276:immunology / Q000628:therapy*; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology / Q000628:therapy*; D005832:Genital Diseases, Male / Q000276:immunology / Q000628:therapy*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D000077271:Imiquimod; D007167:Immunotherapy; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000096:biosynthesis
chemical_list: D000634:Aminoquinolines; D006684:HLA-DR Antigens; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG; D018799:Intercellular Adhesion Molecule-1; D000077271:Imiquimod