Uveitis in Gaucher disease.
OBJECTIVE
Chronic uveitis has been previously reported in a patient with Gaucher's disease and improved with enzyme replacement therapy. This report describes the course of uveitis in two other patients with type I Gaucher's disease.


METHODS
Observational case reports.


METHODS
Review of all patients in a large referral clinic for Gaucher's disease for incidence of uveitis.


RESULTS
Two patients with uveitis among 527 patients (0.4%) were found. Each had a different clinical outcome from the other and from the patient cited in the literature.


CONCLUSIONS
Both patients have mild Gaucher's disease, but one patient has uveitis well controlled for 10 years solely by local corticosteroids, whereas the other has suffered progression of uveitis despite enzyme replacement therapy.
Dweck
Altoon
A
Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel. gaucher@szmc.org.il
Rozenman
Jaacov
J
Ronen
Suzy
S
Zimran
Ari
A
Elstein
Deborah
D
D000328:Adult; D005260:Female; D005776:Gaucher Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D005938:Glucocorticoids / Q000627:therapeutic use; D005962:Glucosylceramidase / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology
D005938:Glucocorticoids; D005962:Glucosylceramidase