title: Novel antitrypanosomal agents.
abstract: Trypanosomes are the causative agents of Chagas' disease in Central and South America and sleeping sickness in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on only six drugs, five of which were developed > 30 years ago. In addition, these drugs display undesirable toxic side effects and the emergence of drug-resistant trypanosomes has been reported. Therefore, the development of new drugs in the treatment of Chagas' disease and sleeping sickness is urgently required. This article summarises the recent progress in identifying novel lead compounds for antitrypanosomal chemotherapy. Particular emphasis is placed on those agents showing promising, selective antitrypanosomal activity.
authors.affiliation: School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 TJ7, UK. dsteverding@hotmail.com
authors.forename: Dietmar
authors.initials: D
authors.lastname: Steverding
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Tyler
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000378:metabolism; D015507:Drugs, Investigational / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D015507:Drugs, Investigational; D014344:Trypanocidal Agents