title: Reexploring the possible roles of some genes associated with nasopharyngeal carcinoma using microarray-based detection.
abstract: In gene expression profiling, nasopharyngeal carcinoma (NPC) 5-8F cells differ from 6-10B cells in terms of their high tumorigenicity and metastatic ability. Differentially expressed genes from the two cell types were analyzed by combining with MILANO (the automatic custom annotation of microarray results which is based on all the available published work in PubMed). The results showed that five genes, including CTSD, P63, CSE1L, BPAG1 and EGR1, have been studied or mentioned in published work on NPC. Subsequently, we reevaluated the roles of these genes in the pathogenesis of NPC by combining the data of gene chips from NPCs versus NPs and pooled cells from 5-8F, 6-10B and CNE2 versus NPs. The results suggested that the roles of BPAG1 and EGR1 are possibly different from those reported in previous NPC studies. These five genes are likely to be involved in the proliferation, apoptosis, invasion and metastasis of NPC. A reexploration of the genes will further define their roles in the pathogenesis of NPC.
authors.affiliation: Cancer Research Institute, Xiangya Medical School, Central South University, Changsha 410078, China.
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Fang
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Liu
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Xie
authors.forename: Xu-Yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Ren
authors.forename: Xin
authors.initials: X
authors.lastname: Deng
authors.forename: Qiu-Zhen
authors.initials: QZ
authors.lastname: Liu
authors.forename: Zhong-Xi
authors.initials: ZX
authors.lastname: Huang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Ding
authors.forename: Kai-Tai
authors.initials: KT
authors.lastname: Yao
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins