title: Image-based diagnosis of Alzheimer-type dementia: measurements of hippocampal and ventricular areas in MR images.
abstract: We studied the possibility of objective diagnosis of Alzheimer-type dementia through radiological findings by evaluating cerebral and hippocampal atrophy in magnetic resonance images of patients with dementia. A statistically significant difference was seen in the hippocampus area index (HAI) and the ventricle area index (VAI) of healthy elderly individuals. Discriminant analysis with these two indexes demonstrated a sensitivity of 90.2% and a specificity of 81.8%, with an overall accuracy of 87.7%. Multiple discriminant analysis with VAI and HAI by stage of dementia showed an overall accuracy of 61.6% for discrimination of four stages. These results indicate that quantitative magnetic resonance imaging measurements can be used as an objective diagnostic technique for Alzheimer-type dementia.
authors.affiliation: Institute of Biomedical Engineering, Nagaoka University of Technology, Niigata, Japan. kodama@stn.nagaokaut.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Kodama
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Fukumoto
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D000704:Analysis of Variance; D001284:Atrophy; D016022:Case-Control Studies; D002552:Cerebral Ventricles / Q000473:pathology*; D016002:Discriminant Analysis; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male