title: Sinus node dysfunction concomitant with Brugada syndrome.
abstract: BACKGROUND
  A genetic correlation between Brugada syndrome (BS) and sinus node dysfunction (SND) has been proposed, although the clinical and electrophysiologic characteristics of this concomitant condition are unknown.
  
  
  RESULTS
  The study comprised 5 patients with symptomatic BS (4 with spontaneous episodes of ventricular fibrillation (VF) and 1 with syncope) of whom 3 had a documented sinus pause > 3 s (a 42- and 62-year-old man, and a 49-year-old woman). Only 1 of them had a family history of sudden death; 2 of them had also had an episode of atrial fibrillation or flutter. Electrophysiologic study demonstrated prolonged sinus node recovery time in 2 patients (2.6 s and > 5 s), in whom a cardiac pacemaker had been implanted before the diagnosis of BS was made after episodes of VF. Finally, all 3 patients received an implantable cardioverter defibrillator, including 2 upgrades from pacemaker.
  
  
  CONCLUSIONS
  SND is not a rare concomitant disorder in BS and there is a possible genetic connection.
authors.affiliation: Department of Cardiology, Juntendo University Shizuoka Hospital, Shizuoka, Japan. sumi@med.juntendo.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Sumiyoshi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakazato
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokano
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yasuda
authors.forename: Yoriaki
authors.initials: Y
authors.lastname: Mineda
authors.forename: Yasuro
authors.initials: Y
authors.lastname: Nakata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D012849:Sinoatrial Node / Q000503:physiopathology*; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy