Structural revision of aspernigrin A, reisolated from Cladosporium herbarum IFB-E002.
Aspernigrin A was reisolated as a secondary metabolite of the Cynodon dactylon-associated endophytic fungus Cladosporium herbarum IFB-E002 coproducing rubrofusarin B, fonsecinone A, 7-hydroxy-4-methoxy-5-methylcoumarin, orlandin, kotanin, and 3beta,5alpha,6beta-trihydroxyergosta-7,22-diene. The structure of aspernigrin A, previously elucidated to be 4-benzyl-6-oxo-1,6-dihydropyridine-3-carboxamide (1), was revised as 6-benzyl-4-oxo-1,4-dihydropyridine-3-carboxamide (2) on the basis of its additional NMR spectroscopic data and the X-ray crystallographic analysis.
Ye
Yong H
YH
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
Zhu
Hai L
HL
Song
Yong C
YC
Liu
Jun Y
JY
Tan
Ren X
RX
D002963:Cladosporium / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004095:Dihydropyridines / Q000737:chemistry* / Q000302:isolation & purification*; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular
D004095:Dihydropyridines; C503028:aspernigrin A