title: Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats.
abstract: The abundance of cellular superoxide dismutase (Mn-SOD) was examined immunocytochemically in different regions of the brain of Long-Evans Cinnamon (LEC) rats at 4 and 50 weeks of age. When all animals develop chronic hepatitis, the substantia nigra and striatum showed a marked increase in Mn-SOD immunoreactivity versus Long-Evans agouti (LEA) rats of the same age. Mn-SOD was localized predominantly in dopaminergic neurons. The elevation of Mn-SOD level in the dopaminergic neurons of LEC rats may reflect the oxidative stress caused by copper accumulation in this brain area. Our data suggest that LEC rats may contribute to the mechanistic study of neurological manifestations in nigro-striatal dopaminergic system of Wilson's disease.
authors.affiliation: Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Dong Woon
authors.initials: DW
authors.lastname: Kim
authors.forename: Tae-Beom
authors.initials: TB
authors.lastname: Ahn
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Gye Sun
authors.initials: GS
authors.lastname: Jeon
authors.forename: Je Hoon
authors.initials: JH
authors.lastname: Seo
authors.forename: Beom S
authors.initials: BS
authors.lastname: Jeon
authors.forename: Sa Sun
authors.initials: SS
authors.lastname: Cho
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006505:Hepatitis / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000201:enzymology / Q000235:genetics; D007150:Immunohistochemistry; D017072:Neostriatum / Q000201:enzymology; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D020332:Rats, Inbred LEC; D013378:Substantia Nigra / Q000201:enzymology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D014446:Tyrosine 3-Monooxygenase; D013482:Superoxide Dismutase; D004298:Dopamine