Androgens and prostate cancer: are the descriptors valid?
The term androgen-independent cancer has now become a misnomer. Given that the androgen receptor can be activated by even low androgen concentrations or via protein modifications or other protein-protein interactions, a growing prostate cancer has the chance of assuming an androgen depletion-independent state, without necessarily bypassing the androgen signaling processes. It is thus suggested that "androgen-independent (AI)" cancer should be more accurately termed "androgen depletion-independent (ADI)" cancer.
Roy-Burman
Pradip
P
Tindall
Donald J
DJ
Robins
Diane M
DM
Greenberg
Norman M
NM
Hendrix
Mary J C
MJ
Mohla
Suresh
S
Getzenberg
Robert H
RH
Isaacs
John T
JT
Pienta
Kenneth J
KJ
D000726:Androgen Antagonists / Q000494:pharmacology; D000728:Androgens / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000502:physiology*; D015398:Signal Transduction
D000726:Androgen Antagonists; D000728:Androgens; D011944:Receptors, Androgen