Positron emission tomography after fetal transplantation in Huntington's disease.
Huntington's disease (HD) is a progressive disorder with no known cure. We report two-year postoperative positron emission tomography (PET) data from 7 HD patients who underwent intrastriatal fetal transplantation. Patients showed widespread reductions in glucose uptake with no significant change over 2 years. Dopamine receptor binding was significantly reduced in HD striatum. D1 binding did not change significantly following transplantation, but there was a significant loss of D2 binding. These findings may reflect loss of graft viability and/or disease progression. There was no significant relationship between changes in PET and clinical function. In summary, there was no benefit from transplantation.
Furtado
Sarah
S
Pacific Parkinson's Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.
Sossi
Vesna
V
Hauser
Roberta A
RA
Samii
Ali
A
Schulzer
Michael
M
Murphy
Colleen B
CB
Freeman
Thomas B
TB
Stoessl
A Jon
AJ
D000704:Analysis of Variance; D016332:Fetal Tissue Transplantation; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods; D011485:Protein Binding / Q000502:physiology; D011954:Receptors, Dopamine / Q000378:metabolism; D013997:Time Factors
D011954:Receptors, Dopamine