Pathophysiological aspects of vascular calcification in chronic renal failure.
The nephrology community has progressively recognized that vascular calcification in patients with chronic renal failure is a major problem in terms of morbidity and mortality. This type of soft tissue calcification is not only passive, as thought previously, but implies active processes as well. It results from disturbances of the normal balance between calcification inhibitors and promoters, acting both at the systemic and the local level, and from the phenotypic change of smooth muscle cells towards osteoblast-like calcifying cells in the vessel wall. The recognition of the main factors involved will allow in the future a more appropriate prophylactic and therapeutic approach of this clinically important complication of chronic renal failure.
Drüeke
T B
TB
Inserm U507 and Service de Néphrologie, Hôpital Necker, Paris. drueke@necker.fr
D000328:Adult; D002114:Calcinosis / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D002118:Calcium / Q000097:blood / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D002648:Child; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008297:Male; D032389:Myocytes, Smooth Muscle / Q000473:pathology; D010641:Phenotype; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus / Q000097:blood; D012306:Risk; D014652:Vascular Diseases / Q000097:blood / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control
D010710:Phosphates; D010758:Phosphorus; D002118:Calcium