Primary platelet adhesion receptors.
Thrombotic diseases such as heart attack and stroke remain a major health concern in the Western world despite existing anti-thrombotic drugs. Current studies are revealing structure-function relationships of primary platelet adhesion receptors mediating adhesion, activation and aggregation, and the molecular mechanisms underlying platelet thrombus formation. Platelet adhesion is relevant not only to thrombotic disease, but there is increasing evidence of a specific role for platelets in vascular processes such as inflammation and atherogenesis. This review focuses on recent advances in understanding the molecular basis for platelet thrombus formation, in particular the receptors, glycoprotein (GP)Ib-IX-V and GPVI, that initiate platelet adhesion and activation at high shear stress.
Yip
Jana
J
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Shen
Yang
Y
Berndt
Michael C
MC
Andrews
Robert K
RK
D003094:Collagen / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008954:Models, Biological; D010973:Platelet Adhesiveness / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D013927:Thrombosis / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism
D016023:Integrins; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor; D003094:Collagen