Recent advances in proton pump inhibitors.
Mechanism of action and shortcomings of the approved proton pump inhibitors are reviewed. Advances in the design of new proton pump K(+) and S site inhibitors are presented. Design criteria incorporated into the structure of investigational proton pump inhibitors to address these drawbacks are discussed.
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Apotex Research Inc, Medicinal Chemistry Department, 150 Signet Drive, Toronto, Ontario M9L 1T9, Canada.
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Leung-Toung
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Karimian
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