The association of race, sociodemographic, and behavioral characteristics with response to highly active antiretroviral therapy in women.
OBJECTIVE
To determine the association of race with clinical and laboratory outcomes after initiation of highly active antiretroviral therapy (HAART) in HIV-1-infected women in the United States.


METHODS
Prospective cohort study.


METHODS
A total of 961 HIV-1-infected women participating in the Women's Interagency HIV Study initiating HAART between July 1, 1995 and September 30, 2003.


RESULTS
Over a median of 5.1 years of follow-up, in univariate Cox regression analyses, white women were more likely than African American women to attain a virologic response (relative hazard [RH]=1.34, P=0.005), less likely to experience viral rebound (RH=0.76, P=0.051), and less likely to die (RH=0.63, P=0.040). There were no significant differences, however, among racial groups in outcomes after adjustment for pre-HAART CD4, HIV-1 RNA, history of AIDS-defining illness, age, antiretroviral therapy use, baseline HIV-1 exposure category, and post-HAART behavioral and clinical variables associated with poorer response (discontinuation of HAART, lower income, smoking, current drug use, and depression). Continuous HAART use and lack of depression differed by race and were the strongest predictors of favorable outcomes.


CONCLUSIONS
No significant differences by race were found in virologic, immunologic, or clinical outcomes after adjustment for continued HAART use and depression. These findings suggest that strategies to enhance HAART continuation, including assessing pharmacogenetic influences that may result in greater toxicity and discontinuation rates, and treating depression can improve individual and population-based effects of treatment and potentially mitigate racial disparities in AIDS-related outcomes.
Anastos
Kathryn
K
Department of Medicine, Montefiore Medical Center, Bronx, NY 10467, USA. kanastos@verizon.net
Schneider
Michael F
MF
Gange
Stephen J
SJ
Minkoff
Howard
H
Greenblatt
Ruth M
RM
Feldman
Joseph
J
Levine
Alexandra
A
Delapenha
Robert
R
Cohen
Mardge
M
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D003863:Depression / Q000150:complications; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000208:ethnology* / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D010349:Patient Compliance; D011446:Prospective Studies; D012959:Socioeconomic Factors