Domino coupling relay approach to polycyclic pyrrole-2-carboxylates.
CuBr2-catalyzed three-component coupling of N-benzylallylamine, ethyl glyoxalate, and terminal alkynes afforded glycine-tethered 1,6-enynes, which were further transformed into polycyclic pyrrole-2-carboxylates via novel cycloisomerization/Diels-Alder cycloaddition/dehydrogenation sequence under iridium-catalyzed conditions.
Yamamoto
Yoshihiko
Y
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan. yamamoto@apchem.nagoya-u.ac.jp
Hayashi
Hiroki
H
Saigoku
Tomoaki
T
Nishiyama
Hisao
H