title: Pure red cell aplasia in B-cell lymphoproliferative disorder treated with rituximab: report of two cases and review of the literature.
abstract: Pure red cell aplasia (PRCA) is an unusual cause of anemia in patients with chronic lymphoproliferative disorders. Here, we present two cases of PRCA, one associated with chronic lymphocytic leukemia (CLL) and the other with splenic marginal zone lymphoma, in which the PRCA responded dramatically to treatment with rituximab. We then review the literature on PRCA in lymphoma and response to rituximab. PRCA associated with CLL or lymphoma may be another indication for rituximab therapy.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Kalyani.Narra@drexel.edu
authors.forename: Kalyani
authors.initials: K
authors.lastname: Narra
authors.forename: Hossein
authors.initials: H
authors.lastname: Borghaei
authors.forename: Tahseen
authors.initials: T
authors.lastname: Al-Saleem
authors.forename: Martin
authors.initials: M
authors.lastname: Höglund
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: Smith
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000069283:Rituximab
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab