Failure to find association between TRAR4 and schizophrenia in the Chinese Han population.
The TRAR4 gene locates in SCZD5 (MIM 603175), which a number of studies have linked with schizophrenia. One recent study suggested that three TRAR4 variants (M1: rs4305745, P=0.0014; M2: rs6903874, P=0.0026; M3: rs6937506, P=0.0052) in the 3'-UTR were associated with schizophrenia. To replicate these findings, we conducted a family-based association study within a sample of 235 Chinese Han trios. However, we didn't find significant evidence of preferential transmission of the three variants across all the trios (all P values>0.2). Thus, we conclude that TRAR4 is not a major or independent determinant in the occurrence of schizophrenia in the Chinese Han population.
Duan
S
S
Bio-X Center, Shanghai Jiao Tong University, Shanghai, China, and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.
Du
J
J
Xu
Y
Y
Xing
Q
Q
Wang
H
H
Wu
S
S
Chen
Q
Q
Li
X
X
Li
X
X
Shen
J
J
Feng
G
G
He
L
L
D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D004252:DNA Mutational Analysis; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D011237:Predictive Value of Tests; D043562:Receptors, G-Protein-Coupled; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D000095383:Trace Amine-Associated Receptors
D018797:Cell Cycle Proteins; D005819:Genetic Markers; D009687:Nuclear Proteins; D043562:Receptors, G-Protein-Coupled; C493988:TAAR6 protein, human; D000095383:Trace Amine-Associated Receptors