Granular-cell basal cell carcinoma of the skin.
Granular cell basal cell carcinoma (GBCC) is a very rare variant of BCC, of which ten cases have been reported in the literature. We describe here a new case of GBCC studied immunohistochemically. The tumor developed on the face of a 71-year old man and showed typical features of GBCC, i.e. a tumor reminiscent of nodular BCC consisting of cells with a granular eosinophilic cytoplasm. Immunohistochemically, tumor cells expressed cytoplasmic reactivity for keratins, CD68 and CD15 antigens, bcl-2 oncoprotein and nuclear reactivity for the p63 protein. Based on a review of the literature, the salient features of GBCC are discussed.
Kanitakis
Jean
J
Laboratory of Dermatopathology, Edouard Herriot Hospital, 69437 Lyon cedex 03, France. kanitakis@lyon.inserm.fr
Chouvet
Brigitte
B
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology