Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors.
In the continuation of efforts to modify the structure of our novel DP-IV inhibitors, a series of pyrazolidine derivatives with heteroaryl urea was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV).
Ahn
Jin Hee
JH
Medicinal Science Division, Korea Research Institute of Chemical Technology, Taejon 305-600, Korea. jhahn@krict.re.kr
Jung
Sun Ho
SH
Kim
Jin Ah
JA
Song
Seog Beom
SB
Kwon
Soon Ji
SJ
Kim
Kwang Rok
KR
Rhee
Sang Dal
SD
Park
Sung-Dae
SD
Lee
Jae Mok
JM
Kim
Sung Soo
SS
Cheon
Hyae Gyeong
HG
D000818:Animals; D018819:Dipeptidyl Peptidase 4 / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*
D011480:Protease Inhibitors; D011720:Pyrazoles; D018819:Dipeptidyl Peptidase 4