Synthesis, proton and 13C NMR and reaction mechanism studies of novel isoindolones derivatives, obtained through TAWERS procedure.
A series of novel isoindolone derivatives (13-18) were prepared in goods yields by applying the TAWERS methodology. A general approach for formation of isoindolones from the aza-Wittig reaction of iminophosphoranes with dialdehydes under neutral and mild conditions was realized. Using 1D NMR a [1,3]-hydride migration was detected. The assignment of the structures and conformation behavior of the derivatives was achieved using 1D and 2D NMR (NOESY, DEPT, HMQC, and HMBC).
Corona
David
D
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior C. Universitaria, Delegación Apartado Postal 70-213, 04510 Coyoacán, México. david.corona@correo.unam.mx
Díaz
Eduardo
E
Guzmán
Angel
A
Jankowski
Christophe K
CK
D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011522:Protons
D007211:Indoles; D011522:Protons