Nonsteroidal anti-inflammatory drugs for rheumatoid arthritis during pregnancy.
OBJECTIVE
I am treating two pregnant patients who have rheumatoid arthritis with nonsteroidal anti-inflammatory drugs. Are these medications safe at high doses during pregnancy?


CONCLUSIONS
While these medications do not appear to increase overall rates of congenital malformations, they do increase the risk of ductus arteriosus constriction or closure.
Florescu
Ana
A
Motherisk Program, Hospital for Sick Children, Toronto, Ont.
Koren
Gideon
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004374:Ductus Arteriosus, Patent / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012306:Risk
D000894:Anti-Inflammatory Agents, Non-Steroidal