[Antidepressant effect of L-tryptophan in male rats with dysbalance thyreoid hormones].
The activity of L-tryptophan was studied on young male rats in depressive state caused by thyreoid hormone dysbalance. The immobilization time in the Porsolt forced swim test in thyreoidectomized rats was significantly increased in comparison to the intact control. The replacement therapy with triiodothyronin (T3) reduced the level of depressed behavior to the initial value. Chronic administration of L-tryptophan significantly decreased the total immobilization time in all the test groups, irrespective of the hormonal state. However, the effect of L-tryptophan was more pronounced in T3-treated rats.
Masalova
O O
OO
Sapronov
N S
NS
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007037:Hypothyroidism / Q000150:complications* / Q000378:metabolism; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism; D014284:Triiodothyronine / Q000627:therapeutic use; D014364:Tryptophan / Q000627:therapeutic use*
D000928:Antidepressive Agents; D014284:Triiodothyronine; D014364:Tryptophan