Amyloid: toward terminology clarification. Report from the Nomenclature Committee of the International Society of Amyloidosis.
The modern nomenclature of amyloidosis now includes 25 human and 8 animal fibril proteins. To be included in the list, the protein has to be a major fibril protein in extracellular deposits, which have the characteristics of amyloid, including affinity for Congo red with resulting green birefringence. Synthetic fibrils with amyloid properties are best named 'amyloid-like'. With increasing knowledge, however, the borders between different protein aggregates tend to become less sharp.
Westermark
Per
P
Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden. Per.Westermark@genpat.uu.se
Benson
Merrill D
MD
Buxbaum
Joel N
JN
Cohen
Alan S
AS
Frangione
Blas
B
Ikeda
Shu-Ichi
S
Masters
Colin L
CL
Merlini
Giampaolo
G
Saraiva
Maria J
MJ
Sipe
Jean D
JD
D000682:Amyloid / Q000145:classification*; D000686:Amyloidosis / Q000145:classification*; D006801:Humans; D009626:Terminology as Topic
D000682:Amyloid