Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats.
The abundance of cellular superoxide dismutase (Mn-SOD) was examined immunocytochemically in different regions of the brain of Long-Evans Cinnamon (LEC) rats at 4 and 50 weeks of age. When all animals develop chronic hepatitis, the substantia nigra and striatum showed a marked increase in Mn-SOD immunoreactivity versus Long-Evans agouti (LEA) rats of the same age. Mn-SOD was localized predominantly in dopaminergic neurons. The elevation of Mn-SOD level in the dopaminergic neurons of LEC rats may reflect the oxidative stress caused by copper accumulation in this brain area. Our data suggest that LEC rats may contribute to the mechanistic study of neurological manifestations in nigro-striatal dopaminergic system of Wilson's disease.
Kim
Dong Woon
DW
Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea.
Ahn
Tae-Beom
TB
Kim
Jong Min
JM
Jeon
Gye Sun
GS
Seo
Je Hoon
JH
Jeon
Beom S
BS
Cho
Sa Sun
SS
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006505:Hepatitis / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000201:enzymology / Q000235:genetics; D007150:Immunohistochemistry; D017072:Neostriatum / Q000201:enzymology; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D020332:Rats, Inbred LEC; D013378:Substantia Nigra / Q000201:enzymology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D013482:Superoxide Dismutase; D004298:Dopamine