[Morpho- and angiogenetic characteristics of uterine leiomyoma].
Ordinary and cellular leiomyomas of 147 patients (age 23 - 65 years) were studied histologically and immunomorphologically. Five females with rapidly growing tumors were operated after therapy with gonadotropines blockers. Variants with weak and pronounced proliferative activity of neoplastic myocytes and various activity of neoangiogenesis were distinguished. The latter may be either phases of development or different tumour types. Use of gonadotropine blockers inhibits myocyte proliferation and activates formation of stroma.
Zaĭrat'iants
O V
OV
Sidorova
I S
IS
Levakov
S A
SA
Levin
E M
EM
Opalenov
K V
KV
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D007889:Leiomyoma / Q000098:blood supply* / Q000145:classification* / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D011506:Proteins / Q000032:analysis; D014594:Uterine Neoplasms / Q000098:blood supply* / Q000145:classification* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011506:Proteins; D042461:Vascular Endothelial Growth Factor A