Angiotensin III as well as angiotensin II regulates water flow through aquaporins in a clam worm.
Angiotensin III has been reported to exist in various animals and tissues. The physiological role, however, is still unclear except that brain angiotensin III is a central regulator of vasopressin release. In this study, angiotensin III as well as angiotensin II enhanced an increase in body weight of clam worms of Perinereis sp. under a hypo-osmotic condition and suppressed a decrease in body weight under a hyper-osmotic condition. When clam worms were treated with tetrachloroaurate (III) after angiotensin-treatment, these enhancing and suppressive effects of the angiotensins under hypo- and hyper-osmotic conditions were inhibited. In contrast, when clam worms were pretreated with tetrachloroaurate (III) before angiotensin-treatment, these effects of angiotensins were not inhibited. Since tetrachloroaurate (III) is a representative blocker of aquaporins, these results indicate that angiotensin III as well as angiotensin II regulates water flow through aquaporins in clam worms.
Satou
Ryousuke
R
United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Nakagawa
Tsutomu
T
Ido
Hiroki
H
Tomomatsu
Masayuki
M
Suzuki
Fumiaki
F
Nakamura
Yukio
Y
D000804:Angiotensin II / Q000494:pharmacology*; D000805:Angiotensin III / Q000494:pharmacology*; D000818:Animals; D000845:Annelida / Q000187:drug effects* / Q000502:physiology; D020346:Aquaporins / Q000037:antagonists & inhibitors / Q000502:physiology*; D001692:Biological Transport / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D017612:Gold Compounds / Q000494:pharmacology; D006982:Hypertonic Solutions / Q000494:pharmacology; D007038:Hypotonic Solutions / Q000494:pharmacology; D008954:Models, Biological; D014867:Water / Q000378:metabolism*
D020346:Aquaporins; D002712:Chlorides; D017612:Gold Compounds; D006982:Hypertonic Solutions; D007038:Hypotonic Solutions; D014867:Water; D000804:Angiotensin II; D000805:Angiotensin III; C024568:gold tetrachloride, acid