title: Molecular design, chemical synthesis, and evaluation of cytosine-carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA.
abstract: The designed cytosine-carbohydrate hybrid molecule selectively recognized and stabilized the bulged duplex DNA possessing the complementary bulged DNA base, guanine, while the nucleotide base itself did not exhibit any such ability. It was also found that the assistance of the carbohydrate to stabilize the interaction between the nucleotide base and the complementally bulge DNA base is very helpful for the selective recognition and stabilization of the single-bulged duplex DNA.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Idutsu
authors.forename: Ayaka
authors.initials: A
authors.lastname: Sasaki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsumura
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
mesh_terms: D020137:Base Pair Mismatch; D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry*; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D006147:Guanine; D007364:Intercalating Agents; D015335:Molecular Probes; D009691:Nucleic Acid Denaturation; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D002241:Carbohydrates; D007364:Intercalating Agents; D015335:Molecular Probes; D006147:Guanine; D003596:Cytosine; D004247:DNA