title: Biofilm formation by Salmonella enterica serovar Typhimurium and Escherichia coli on epithelial cells following mixed inoculations.
abstract: Biofilms were formed by inoculations of Salmonella enterica serovar Typhimurium and Escherichia coli on HEp-2 cells. Inoculations of S. enterica serovar Typhimurium and E. coli resulted in the formation of an extensive biofilm of S. enterica serovar Typhimurium. In experiments where an E. coli biofilm was first formed followed by challenge with S. enterica serovar Typhimurium, there was significant biofilm formation by S. enterica serovar Typhimurium. The results of this study indicate that S. enterica serovar Typhimurium can outgrow E. coli in heterologous infections and displace E. coli when it forms a biofilm on HEp-2 cells.
authors.affiliation: Department of Microbiology, University of Iowa College of Medicine, 51 Newton Road, 3334 -BSB, Iowa City, IA 52242, USA.
authors.forename: Cristina L C
authors.initials: CL
authors.lastname: Esteves
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Jones
authors.forename: Steven
authors.initials: S
authors.lastname: Clegg
mesh_terms: D018441:Biofilms; D018920:Coculture Techniques; D004847:Epithelial Cells / Q000382:microbiology*; D004926:Escherichia coli; D017930:Genes, Reporter; D006801:Humans; D012486:Salmonella typhimurium / Q000254:growth & development