title: [An experimental study on repairing bone defect with the biodegradable polycaprolactone material].
abstract: OBJECTIVE
  To investigate the ability of the biodegradable polycaprolactone (PCL) material to repair bone defect and to evaluate the feasibility of using the PCL as the scaffold in tissue engineering bone.
  
  
  METHODS
  The bone defect models of 4. 5 mm x 12 mm were made in the bilateral femoral condyle of 65 New Zealand white rabbits. The PCL cylinder was implanted into the right side of defect (experimental group, n = 60), the high dense hydroxyapatite was implanted into the left side of defect (control group, n = 60), and the incision was sutured without any implants (blank group, n = 5). The samples were harvested and observed by examinations of gross, X-ray, bone density, 99mTc-MDP bone scanning, gamma-display ratio and scanning electron microscope (SEM) after 3, 6, 9 and 12 months of operation. The results were compared between the experimental group and control group.
  
  
  RESULTS
  At 3, 6, 9 and 12 months after operation, the gross and X-ray examinations indicated that the bone defect filled with the new bone on the PCL-tissue surface, and no delayed inflammatory reaction appeared. The average bone mineral density was greater in the experimental group than that in the control group, and the difference had statistical significance (P< 0. 05). The results of 99mTc-MDP bone scanning and gamma-display ratio showed that the nuclide uptake was more in the PCL group than that in the control group. The SEM result proved that the new compact bone formed on the PCL migrating surface as the PCL degraded gradually,but the collagen fiber sheath formed around the hydroxyapatite in the control group.
  
  
  CONCLUSIONS
  PCL possesses good biocompatibility and high bone inductive potentiality, it can be used to repair bone defect.
authors.affiliation: Orthopedics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China. ahmatjiang@hotmail.com
authors.forename: Yusup
authors.initials: Y
authors.lastname: Aahmat
authors.forename: Tongyi
authors.initials: T
authors.lastname: Chen
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Chen
authors.forename: Dapeng
authors.initials: D
authors.lastname: Liu
authors.forename: Zhenbin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D001847:Bone Diseases / Q000503:physiopathology / Q000601:surgery*; D001861:Bone Regeneration; D018786:Bone Substitutes; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005260:Female; D005269:Femur / Q000293:injuries / Q000503:physiopathology / Q000601:surgery; D048091:Guided Tissue Regeneration; D008297:Male; D011091:Polyesters; D011817:Rabbits; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters