title: In vitro efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus.
abstract: We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V. vulnificus in vitro, and this combination regimen can be a good choice as the empirical treatment for suspected necrotizing fasciitis due to V. vulnificus.
authors.affiliation: Department of Laboratory Medicine, Chosun University Medical School, 588 Seoseok-dong, Dong-gu, Gwang-Ju 501-717, South Korea.
authors.forename: Dong-Min
authors.initials: DM
authors.lastname: Kim
authors.forename: Yong
authors.initials: Y
authors.lastname: Lym
authors.forename: Sook Jin
authors.initials: SJ
authors.lastname: Jang
authors.forename: Hulin
authors.initials: H
authors.lastname: Han
authors.forename: Young Gi
authors.initials: YG
authors.lastname: Kim
authors.forename: Choon-Hae
authors.initials: CH
authors.lastname: Chung
authors.forename: Soon Pyo
authors.initials: SP
authors.lastname: Hong
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000592:standards; D002439:Cefotaxime / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008911:Minocycline / Q000494:pharmacology; D041261:Vibrio vulnificus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D008911:Minocycline; D002439:Cefotaxime