The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell proliferation, cell survival and cell migration. Given that the development of malignancy is often associated with perturbations in these processes, it is not surprising that FAK activity is altered in cancer cells. Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target.
McLean
Gordon W
GW
The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.
Carragher
Neil O
NO
Avizienyte
Egle
E
Evans
Jeff
J
Brunton
Valerie G
VG
Frame
Margaret C
MC
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D018450:Disease Progression; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009369:Neoplasms / Q000503:physiopathology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction
D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; C496051:Ptk2 protein, mouse