Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: a protective role for IL-10?
HIV infection causes immune activation that leads to oxidative damage. Proinflammatory cytokines may promote such damage and the regulatory cytokine IL-10 may protect against such damage. To examine the relation of these cytokines to oxidative damage, 67 cases of oxidative damage and 67 matched controls were selected from the reaching for excellence in adolescent health (REACH) study. Subjects were young (15-23 years), largely female (76%), HIV-positive (73%) and black (69%). Proinflammatory cytokines were not significantly associated with oxidative damage but plasma IL-10 had a significant, negative association with oxidative damage. This finding is consistent with a protective role for IL-10 in diminishing oxidative damage during immune activation.
Stephensen
Charles B
CB
USDA-ARS Western Human Nutrition Research Center at the University of California, Davis and Department of Nutrition, University of California, Davis, CA 95616, USA.
Marquis
Grace S
GS
Douglas
Steven D
SD
Wilson
Craig M
CM
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology*; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology*; D016015:Logistic Models; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000276:immunology*
D016207:Cytokines; D016753:Interleukin-10; D008315:Malondialdehyde