Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. II. Structure elucidation.
The structures of citridones A, B, B' and C, new potentiators of miconazole activity against Candida albicans produced by Penicillium sp. FKI-1938, were elucidated by various spectroscopic analyses including UV, NMR, and MS and degradation experiments. Although citridones B and B' were isolated as a mixture, each structure was also elucidated, indicating that they exist in equilibrium of hemiacetal epimerization. Citridones A, B and B' have a similar phenylfuropyridone moiety.
Fukuda
Takashi
T
School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000935:Antifungal Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004357:Drug Synergism; D005663:Furans / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008825:Miconazole / Q000494:pharmacology; D008968:Molecular Conformation; D010407:Penicillium / Q000378:metabolism*; D011728:Pyridones / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D005663:Furans; D011728:Pyridones; D008825:Miconazole