title: A phenoxazine compound, 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one reverses the phenylephrine or high-K+ induced contraction of smooth muscles in rat aorta and guinea pig tenia cecum.
abstract: 2-Amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one (Phx-1) reversed concentration dependently the contraction of both rat aorta and guinea pig tenia cecum induced by phenylephrine or high-K(+). Since Phx-1 suppresses the responses of human mononuclear cells to phytohemagglutinin, (Akazawa et al. Tohoku J. Exp. Med., 196, 185-192, 2002), Phx-1 may be useful for developing new vasorelaxing agents with immunosuppressive action.
authors.affiliation: Department of Physiology, Tokyo Medical University, Tokyo 460-8402, Japan.
authors.forename: Saifuding
authors.initials: S
authors.lastname: Musha
authors.forename: Masaru
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yukisato
authors.initials: Y
authors.lastname: Ishida
authors.forename: Seiko
authors.initials: S
authors.lastname: Kato
authors.forename: Masato
authors.initials: M
authors.lastname: Konishi
authors.forename: Akio
authors.initials: A
authors.lastname: Tomoda
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000502:physiology; D002432:Cecum / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010078:Oxazines / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats
chemical_list: C104202:2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one; D010078:Oxazines; D010656:Phenylephrine; D011188:Potassium