[Effects of orthodontic force on tumor necrosis factor alpha protein expression in the inflammatory periodontal tissues].
OBJECTIVE
To explore the combined effects of orthodontic force and inflammation on the remodelling of periodontal tissues.


METHODS
The upper first molars underwent mesial orthodontic force on 48 rats suffering experimental periodontitis and 48 rats injected lipopolysaccharide, respectively.


RESULTS
The TNF-alpha protein expression in the compressed periodontal tissues fluctuated during 0, 2, 12 hours and 2, 7, 14 days stages, the OD value got to the peak in the compressed periodontal tissues in 2 days.


CONCLUSIONS
The mechanical remodelling effects were hindered due to the circumstance of acute or chronic inflammation. The research suggests that the orthodontic treatment to adult patients with periodontal inflammation should be taken carefully.
Xiao
Li-Wen
LW
Dental Department, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Chen
Yang-Xi
YX
Bai
Ding
D
Zhang
Jing-Ju
JJ
Duan
Pei-Jia
PJ
D000328:Adult; D000818:Animals; D006801:Humans; D008963:Molar; D010518:Periodontitis; D051381:Rats; D013314:Stress, Mechanical; D014409:Tumor Necrosis Factor-alpha
D014409:Tumor Necrosis Factor-alpha