title: The reaction of [Fe(pic)3] with hydrogen peroxide: a UV-visible and EPR spectroscopic study (Hpic = picolinic acid).
abstract: The Gif family of catalysts, based on an iron salt and O2 or H2O2 in pyridine, allows the oxygenation of cyclic saturated hydrocarbons to ketones and alcohols under mild conditions. The reaction between [Fe(pic)3] and hydrogen peroxide in pyridine under GoAgg(III)(Fe(III)/Hpic catalyst) conditions was investigated by UV-visible spectrophotometry. Reactions were monitored at 430 and 520 nm over periods ranging from a few minutes to several hours at 20 degrees C. A number of kinetically stable intermediates were detected, and their relevance to the processes involved in the assembly of the active GoAgg(III) catalyst was determined by measuring the kinetics in the presence and absence of cyclohexane. EPR measurements at 110 K using hydrogen peroxide and t-BuOOH as oxidants were used to further probe these intermediates. Our results indicate that in wet pyridine [Fe(pic)3] undergoes reversible dissociation of one picolinate ligand, establishing an equilibrium with [Fe(pic)2(py)(OH)]. Addition of aqueous hydrogen peroxide rapidly generates the high-spin complex [Fe(pic)2(py)(eta1-OOH)] from the labilised hydroxy species. Subsequently the hydroperoxy species undergoes homolysis of the Fe-O bond, generating HOO. and [Fe(pic)2(py)2], the active oxygenation catalyst.
authors.affiliation: School of Chemistry, University of St Andrews, St Andrews, Fife, Scotland, UK KY16 9ST. slj2@st-andrews.ac.uk
authors.forename: Sneh L
authors.initials: SL
authors.lastname: Jain
authors.forename: Pravat
authors.initials: P
authors.lastname: Bhattacharyya
mesh_terms: D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005290:Ferric Compounds / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007700:Kinetics; D010848:Picolinic Acids / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013997:Time Factors
chemical_list: D005290:Ferric Compounds; D010848:Picolinic Acids; D006861:Hydrogen Peroxide; C030614:picolinic acid