tRNA turnaround.
Two recently published papers (Takano et al., 2005 and Shaheen and Hopper, 2005) demonstrate that in S. cerevisiae, cytoplasmic tRNAs can be transported into the nucleus. This retrograde movement may expose mature tRNAs to nuclear proofreading or it may regulate tRNA availability in response to amino acid availability.
Dahlberg
James
J
Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA.
Lund
Elsebet
E
D021581:Active Transport, Cell Nucleus; D000596:Amino Acids / Q000172:deficiency / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D008954:Models, Biological; D029543:Nucleocytoplasmic Transport Proteins / Q000378:metabolism; D012326:RNA Splicing; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D020931:ran GTP-Binding Protein / Q000378:metabolism
D000596:Amino Acids; C110033:MTR10 protein, S cerevisiae; D029543:Nucleocytoplasmic Transport Proteins; D012331:RNA, Fungal; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D012343:RNA, Transfer; D020931:ran GTP-Binding Protein