Elevated TFPI levels in female hyperhomocysteinemic patients.
OBJECTIVE
Hyperhomocysteinemia is a risk factor for cardiovascular diseases, while tissue factor pathway inhibitor (TFPI) regulates the extrinsic pathway of blood coagulation. We investigated the in vivo influence of elevated homocysteine concentrations on TFPI levels.


METHODS
Total TFPI levels of 82 hyperhomocysteinemic patients were determined.


RESULTS
The patients' TFPI levels were significantly elevated compared to blood donors, with a more pronounced effect in females than in males.


CONCLUSIONS
We have shown a gender-dependent TFPI elevation in hyperhomocysteinemic patients.
Thyzel
Elmar
E
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Siegling
Sabine
S
Götting
Christian
C
Kleesiek
Knut
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013923:Thromboembolism / Q000097:blood / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D015415:Biomarkers; D008074:Lipoproteins; D014280:Triglycerides; C051928:lipoprotein-associated coagulation inhibitor; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine