Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction.
Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis-related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.
Mizuno
Hiroya
H
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Sato
Hiroshi
H
Sakata
Yasuhiko
Y
Ohnishi
Yozo
Y
Hishida
Eiji
E
Kinjo
Kunihiro
K
Nakatani
Daisaku
D
Shimizu
Masahiko
M
Kondo
Hiroya
H
Tanaka
Toshihiro
T
Ozaki
Kouichi
K
Hirayama
Atsushi
A
Ito
Hiroshi
H
Otsu
Kinya
K
Hori
Masatsugu
M
D050197:Atherosclerosis / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic; D011379:Prognosis; D012008:Recurrence; D015996:Survival Rate
D008233:Lymphotoxin-alpha