Insights into the role of fibroblasts in human autoimmune diseases.
Traditional wisdom has considered fibroblasts as contributing to the structural integrity of tissues rather than playing a dynamic role in physiological or pathological processes. It is only recently that they have been recognized as comprising diverse populations of cells exhibiting complex patterns of biosynthetic activity. They represent determinants that react to stimuli and help define tissue remodelling through the expression of molecules imposing constraints on their cellular neighbourhood. Moreover, fibroblasts can initiate the earliest molecular events leading to inflammatory responses. Thus they must now be viewed as active participants in tissue reactivity. In this short review, I will provide an overview of contemporary thought about the contribution of fibroblasts to the pathogenesis of autoimmune processes through their expression of, and responses to, mediators of inflammation and tissue remodelling.
Smith
T J
TJ
Division of Molecular Medicine, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. tjsmith@ucla.edu
D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D019013:CD40 Antigens / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D009915:Orbit / Q000276:immunology; D017526:Receptor, IGF Type 1 / Q000276:immunology; D011989:Receptors, Thyrotropin / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology
D019013:CD40 Antigens; D016207:Cytokines; D011989:Receptors, Thyrotropin; D023201:CD40 Ligand; D017526:Receptor, IGF Type 1