title: Response of diffuse sclerosing osteomyelitis of the mandible to alendronate: follow-up study by 99mTc scintigraphy.
abstract: We report a case of diffuse sclerosing osteomyelitis of the mandible responded to alendronate, after a poor response to intravenous antibiotics, antibiotic irrigation-perfusion, and decortication. The patient was given an intravenous infusion of 10mg of alendronate. Pain resolved within 24 h. There were no severe adverse events. Increased uptake of 99mTc in the mandible almost completely disappeared 3 months after treatment.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime, Japan. sahino@m.ehime-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Hino
authors.forename: R
authors.initials: R
authors.lastname: Murase
authors.forename: N
authors.initials: N
authors.lastname: Terakado
authors.forename: S
authors.initials: S
authors.lastname: Shintani
authors.forename: H
authors.initials: H
authors.lastname: Hamakawa
mesh_terms: D000328:Adult; D019386:Alendronate / Q000008:administration & dosage / Q000627:therapeutic use*; D005157:Facial Pain / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008334:Mandible / Q000000981:diagnostic imaging*; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013667:Technetium
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium; D019386:Alendronate