title: [Hearing screening in infants with congenital cytomegalovirus infection].
abstract: To investigate the impact of congenital cytomegalovirus infection on the hearing ability in infants.
  
  
  
  By using the tools of distortion product otoacoustic emission (DPOAE) and auditory brain-stem response (ABR), the hearing ability of 38 infants with congenital cytomegalovirus infection and 16 cases of normal controls during neonatal periods was screened with a follow-up study at 6 and 24 months.
  
  
  
  In infants with congenital cytomegalovirus infection, 86.8% (66/76) ears at neonatal stage and 76.3% (58/76) ears at 6 months passed the tests; while in normal controls, 96.9% (31/32) ears passed the tests. The reaction threshold of ABR V in infants with congenital cytomegalovirus infection was higher than that in normal controls (P<0.005). Furthermore,in infants with congenital cytomegalovirus infection, 13 ears (17.1%) were extreme hearing loss, 5 ears (6.6%) were severe hearing loss, and 6 ears (7.9%) were moderately severe hearing loss. The incidence of hearing loss during the follow-up was 7.9% (3/38) at neonatal stage, 23.7% (9/38) at 3-4 months, and 7.9% (3/38) after 6 months.
  
  
  
  The congenital cytomegalovirus infection could cause the prompt and late-onset hearing loss. The combination of the laboratory evidence with the dynamic hearing screening may contribute to the early detection of hearing loss in infants with congenital cytomegalovirus infection.
authors.affiliation: The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. mowei@yahoo.com.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Mo
authors.forename: Yi-ying
authors.initials: YY
authors.lastname: Zhang
authors.forename: Yun-qiu
authors.initials: YQ
authors.lastname: Lei
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Pei-fen
authors.initials: PF
authors.lastname: Shao
authors.forename: Yue-feng
authors.initials: YF
authors.lastname: Sun
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zhou
authors.forename: Zheng-yan
authors.initials: ZY
authors.lastname: Zhao
mesh_terms: D002681:China / Q000453:epidemiology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005500:Follow-Up Studies; D006312:Hearing Loss, Bilateral / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D017084:Otoacoustic Emissions, Spontaneous