title: When pouring water on the fire makes it burn brighter.
abstract: Earlier work seems to suggest that overexpression of uncoupling protein 1 would be anti-inflammatory. However, new findings show that expression of uncoupling protein 1 in aortic smooth muscle cells of mice increases reactive oxygen species, activates the renin-angiotensin system, elevates blood pressure, and worsens atherosclerosis.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Fogelman
mesh_terms: D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D001794:Blood Pressure; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007473:Ion Channels; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D024101:Mitochondrial Proteins; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000473:pathology; D010743:Phospholipids / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012083:Renin / Q000378:metabolism; D000071256:Uncoupling Protein 1
chemical_list: D000809:Angiotensins; D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D010743:Phospholipids; D017382:Reactive Oxygen Species; C000604371:UCP1 protein, human; C000604372:Ucp1 protein, mouse; D000071256:Uncoupling Protein 1; D012083:Renin