title: Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay.
abstract: Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.
authors.affiliation: The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia.
authors.forename: Kate L
authors.initials: KL
authors.lastname: Seib
authors.forename: Mark P
authors.initials: MP
authors.lastname: Simons
authors.forename: Hsing-Ju
authors.initials: HJ
authors.lastname: Wu
authors.forename: Alastair G
authors.initials: AG
authors.lastname: McEwan
authors.forename: William M
authors.initials: WM
authors.lastname: Nauseef
authors.forename: Michael A
authors.initials: MA
authors.lastname: Apicella
authors.forename: Michael P
authors.initials: MP
authors.lastname: Jennings
mesh_terms: D001681:Biological Assay; D002470:Cell Survival; D006069:Gonorrhea / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism* / Q000382:microbiology*; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*