title: [Efficacy of cow's kumiss in the treatment of large intestine dysbacteriosis and its impact on tolerability of antituberculosis agents in patients with respiratory tract tuberculosis].
abstract: Dysbacteriosis of the large intestine is one of severe complications of long-term use of antituberculosis agents in the treatment of respiratory tract tuberculosis that results in a significant decrease of tolerability of antituberculosis agents, persistence of tuberculosis intoxication and slower involution of the tuberculosis process in the lungs. When the complex treatment with antituberculosis agents was accompanied by the use of cow's kumiss for correction of the large intestine dysbacteriosis, the intoxication signs disappeared in 12% of the patients in the main group, while in the patients of the control group the level of the intoxication syndrome increased twice. The rate of the tuberculosis lesions regression evident from the lung roentgenograms was 2.7-fold higher in the main group vs. the control (62 and 23% respectively). The indices of the lung functional capacity recovery in the patients of the main group vs. the control were also higher (41 and 33% respectively). Hepatic toxic reactions in the patients not given cow's kumiss for correction of dysbacteriosis were 8 times more frequent vs. the control. The results of the study made it possible to develop recommendations for phthisiologists in the use of cow's kumiss as one of the methods of pathogenetic therapy in complex treatment of patients with respiratory tract tuberculosis in sanatoria.
authors.forename: N I
authors.initials: NI
authors.lastname: Dugina
authors.forename: S D
authors.initials: SD
authors.lastname: Mitrokhin
authors.forename: T V
authors.initials: TV
authors.lastname: Chebotareva
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003108:Colonic Diseases / Q000178:diet therapy* / Q000209:etiology / Q000382:microbiology; D003611:Dairy Products; D005260:Female; D006801:Humans; D007420:Intestine, Large / Q000382:microbiology; D008297:Male; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents