title: Koshikamide A2, a cytotoxic linear undecapeptide isolated from a marine sponge of Theonella sp.
abstract: Koshikamide A2 (2) was isolated as a cytotoxic metabolite from a marine sponge of Theonella sp. Its structure was elucidated to be a linear undecapeptide by spectroscopic and chemical methods, together with enzymatic conversion to known koshikamide A1 (1). The new peptide moderately inhibited the growth of P388 murine leukemia cells.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Araki
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047232:Theonella / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; C506242:koshikamide A2