title: Fetal Doppler Hypoxic index for the prediction of abnormal fetal heart rate at delivery in chronic fetal distress.
abstract: OBJECTIVE
  To design a Doppler Hypoxic index (HI), which takes into account both the duration and the intensity of fetal flow redistribution (i.e. hypoxia) for predicting the occurrence of abnormal fetal heart rate (FHR) at delivery.
  
  
  METHODS
  Sixty-six pregnancies with hypertension and/or growth retardation (IUGR) were investigated (age: 23+/-5 years; primigravidas: 30%, CS 59%; hospitalisation: 10+/-8 days, IUGR (<10 c) 82%, intensive care 23%, fetal death 1). Umbilical (URI) and cerebral (CRI) Doppler resistance indices, and the C/U ratio (CRI/URI) were measured every 2 days from admission to delivery. HI was calculated by summing the daily %C/U reduction (in % from normal cut-off limit 1.1) over the period of observation (or mean C/U reduction in % from 1.1 x number of days of observation). Doppler C/U and HI were compared with fetal heart rate (FHR) traces, and perinatal data.
  
  
  RESULTS
  HI > 160% was associated with abnormal FHR in 80% of the cases (PPV = 87%, NPV = 88%). HI > 160% predicted the occurrence of abnormal FHR 8+/-6 days before they happened.
  
  
  CONCLUSIONS
  A combination of intensity and duration of the fetal flow redistribution (i.e. hypoxia) evaluated by Doppler is correlated with the occurrence of abnormal fetal heart rate.
authors.affiliation: Unité INSERM 619, CHU Hôpital Trousseau, 37044 Tours, France. arbeille@med.univ-tours.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Arbeille
authors.forename: Franck
authors.initials: F
authors.lastname: Perrotin
authors.forename: Aida
authors.initials: A
authors.lastname: Salihagic
authors.forename: Hakan
authors.initials: H
authors.lastname: Sthale
authors.forename: Jacques
authors.initials: J
authors.lastname: Lansac
authors.forename: Lawrence D
authors.initials: LD
authors.lastname: Platt
mesh_terms: D000328:Adult; D002908:Chronic Disease; D036861:Delivery, Obstetric; D005260:Female; D005316:Fetal Distress / Q000150:complications*; D005317:Fetal Growth Retardation; D005311:Fetal Hypoxia / Q000175:diagnosis*; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D018608:Ultrasonography, Doppler / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods*