title: Origin of plasmid-mediated quinolone resistance determinant QnrA.
abstract: Plasmid-mediated resistance to quinolones is increasingly reported in studies of Enterobacteriaceae. Using a PCR-based strategy, a series of gram-negative species were screened for qnrA-like genes. Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78, rue du General Leclerc, 94275 Le Kremlin-Bicêtre, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Jose-Manuel
authors.initials: JM
authors.lastname: Rodriguez-Martinez
authors.forename: Hedi
authors.initials: H
authors.lastname: Mammeri
authors.forename: Alain
authors.initials: A
authors.lastname: Liard
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015363:Quinolones / Q000494:pharmacology*; D020592:Shewanella / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D014871:Water Microbiology
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D015363:Quinolones