title: Septic knee arthritis after intra-articular hyaluronate injection. Two case reports.
abstract: Intraarticular sodium hyaluronate injection to treat osteoarthritis is associated with minor side effects. Infections seem uncommon. We report two cases of septic knee arthritis. One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids. In the other patient, a 78-year-old woman, Neisseria mucosa knee arthritis occurred after a single sodium hyaluronate injection. Faultless aseptic technique is essential when administering hyaluronate viscosupplementation. Patients should be informed of the risk of septic arthritis.
authors.affiliation: Rheumatology Department, Archet 1 Teaching Hospital, CHU de Nice, 151 Rte St Antoine de Ginestière, BP 3079, 06202 Nice cedex 3, France. albert-sabonnadiere.c@chu-nice.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Albert
authors.forename: Olivier
authors.initials: O
authors.lastname: Brocq
authors.forename: Delphine
authors.initials: D
authors.lastname: Gerard
authors.forename: Christian
authors.initials: C
authors.lastname: Roux
authors.forename: Liana
authors.initials: L
authors.lastname: Euller-Ziegler
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects / Q000473:pathology; D042807:Neisseria mucosa / Q000302:isolation & purification / Q000502:physiology; D016870:Neisseriaceae Infections / Q000209:etiology* / Q000473:pathology; D020370:Osteoarthritis, Knee / Q000150:complications / Q000188:drug therapy*; D010068:Oxacillin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000209:etiology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000502:physiology
chemical_list: D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006820:Hyaluronic Acid; D010068:Oxacillin