The sweet and sour of cancer: glycans as novel therapeutic targets.
A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules. Such novel agents might be used alone or in combination with operative and/or chemoradiation strategies for treating cancer.
Fuster
Mark M
MM
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, 92093-0687, USA.
Esko
Jeffrey D
JD
D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D009385:Neoplastic Processes; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D011134:Polysaccharides / Q000502:physiology*; D019139:Tumor Escape / Q000276:immunology
D011134:Polysaccharides