title: Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents.
abstract: A series of Oroxylin A derivatives, prepared by alkylation and condensation, were fully characterized by spectroscopic methods. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that acylation of 7-OH group in Oroxylin A significantly enhanced the activity as compared to their parent compound (Oroxylin A).
authors.affiliation: Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: T
authors.initials: T
authors.lastname: Hari Babu
authors.forename: P V
authors.initials: PV
authors.lastname: Srinivas
authors.forename: B S
authors.initials: BS
authors.lastname: Sastry
authors.forename: K
authors.initials: K
authors.lastname: Hara Kishore
authors.forename: U S N
authors.initials: US
authors.lastname: Murty
authors.forename: J
authors.initials: J
authors.lastname: Madhusudana Rao
mesh_terms: D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids; C080669:5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one