title: The elastin connection and melanoma progression.
abstract: Matrikines, i.e. matrix fragments with cytokine-like properties, have been ascribed a major role in regulating tumour progression. The invasive front of melanoma is characterised by intense fragmentation of dermal elastic fibres. Elastase-mediated elastolysis liberates elastin fragments, i.e. elastokines, that stimulate several aspects of melanoma progression such as to enhance melanoma cell invasion through type I collagen or increase angiogenesis. Induced-membrane-type 1 metalloprotease (MT1-MMP) expression following elastin receptor (S-Gal) occupancy by elastokines is responsible for those biological activities. Several matrix-derived peptides with a GXXPG consensus sequence adopting a type VIII beta-turn conformation were as potent as elastokines in promoting angiogenesis in a Matrigel assay, and galectin-3 also contains several similar repeats within its N-terminal domain. We propose that S-Gal might constitute a novel therapeutic target for controlling melanoma progression.
authors.affiliation: UMR 6198 CNRS, IFR 53 Biomolecules, Université de Reims, Reims, France. william.hornebeck@univ-reims.fr
authors.forename: William
authors.initials: W
authors.lastname: Hornebeck
authors.forename: Arnaud
authors.initials: A
authors.lastname: Robinet
authors.forename: Laurent
authors.initials: L
authors.lastname: Duca
authors.forename: Frank
authors.initials: F
authors.lastname: Antonicelli
authors.forename: Jean
authors.initials: J
authors.lastname: Wallach
authors.forename: Georges
authors.initials: G
authors.lastname: Bellon
mesh_terms: D000595:Amino Acid Sequence; D018450:Disease Progression; D004549:Elastin / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology*; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D011956:Receptors, Cell Surface; C054901:elastin-binding proteins; D004549:Elastin; D020782:Matrix Metalloproteinases