title: Feasibility of US-guided high-intensity focused ultrasound treatment in patients with advanced pancreatic cancer: initial experience.
abstract: The study was approved by the university ethics committee, and informed consent was obtained from all patients. The purpose of this study was to prospectively evaluate ultrasonographically guided high-intensity focused ultrasound in the treatment of patients with advanced-stage pancreatic cancer. Eight patients underwent high-intensity focused ultrasound ablation, and laboratory and radiologic examinations were performed after intervention. Changes in symptoms and survival time were noted at follow-up. No complications were observed, and preexisting severe back pain disappeared after intervention. Follow-up images revealed an absence of tumor blood supply and shrinkage of the ablated tumor. Four patients died, and four patients were alive at the time of this writing, with a median survival time of 11.25 months. The authors conclude that high-intensity focused ultrasound ablation is safe and feasible in the treatment of advanced pancreatic cancer.
authors.affiliation: Institute of Ultrasonic Engineering in Medicine and Clinical Center for Tumor Therapy of 2nd Affiliated Hospital, Chongqing University of Medical Sciences, 1 Medical College Road, Box 153, Chongqing 400016, China. mfengwu@yahoo.com
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.forename: Zhi-Biao
authors.initials: ZB
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Chen
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Zou
authors.forename: Jin
authors.initials: J
authors.lastname: Bai
authors.forename: Ke-Quan
authors.initials: KQ
authors.lastname: Li
authors.forename: Cheng-Bing
authors.initials: CB
authors.lastname: Jin
authors.forename: Fang-Lin
authors.initials: FL
authors.lastname: Xie
authors.forename: Hai-Bing
authors.initials: HB
authors.lastname: Su
mesh_terms: D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D018084:Ultrasonography, Interventional