Combining multiple quantitative and qualitative goals when assessing biomanufacturing strategies under uncertainty.
This paper reports how financial and operational results from bioprocess simulations can be combined with other criteria pertinent to decision-making predictions to provide a more holistic approach to the evaluation of biomanufacturing alternatives. The classical additive weighting method, which is a multiattribute decision-making technique that can account for both the quantitative and qualitative parameters that ultimately need to be considered, is used. Its application is demonstrated through a case study that addresses whether start-up companies should invest in a stainless steel pilot plant or use disposable equipment for the production of early phase clinical trial material. The technique is extended to allow for uncertainty in parameters. An illustration of its use to compare alternatives based on cumulative frequency curves of the aggregate scores is provided. For cases where it is difficult to discriminate between the options, plots of risk versus reward are shown to be useful for identifying the best alternative based on the risk preference of the company's management.
Farid
Suzanne S
SS
The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. s.farid@ucl.ac.uk
Washbrook
John
J
Titchener-Hooker
Nigel J
NJ
D001709:Biotechnology / Q000191:economics / Q000379:methods* / Q000458:organization & administration; D003661:Decision Support Techniques; D009010:Monte Carlo Method; D013269:Stochastic Processes