[A retrospective cohort study on the natural history of human immunodeficiency virus among formal plasma donors in central China].
OBJECTIVE
To study the time span from human immunodeficiency virus (HIV) infection to full bloom AIDS and to death.


METHODS
Among formal plasma donors (FPD) from 2 counties in central China, 178 HIV cases were confirmed by western blot method but received no ARV treatment under a retrospective cohort study. Data on personal information, history on plasma donation, as well as dates regarding HIV diagnostic confirmation, onset of AIDS and death was collected through reviewing laboratory and medical records thus the course of disease for each case was identified. Incubation and survival time were calculated, using Kaplan-Meier method.


RESULTS
The incubation period was 8.31 years on average (95% CI: 8.04 - 8.58 years). The cumulative incidence rate of AIDS was 6.41/100 person-years after HIV infection. The survival time was 9.90 (95% CI: 8.20 - 11.60) months after the onset of AIDS.


CONCLUSIONS
According to the findings from this study, the average incubation was shorter than 9.5 years which was reported by UNAIDS. Comparing with figures that had been reported by UNAIDS, AIDS incidence rate among this population was lower within 6 years but higher since the 7th year on after being infected but the survival time was shorter.
Lü
Fan
F
National Center for Sexually Transmitted Disease and Acquired Immune Deficiency Syndrome Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhang
Li-fen
LF
Wang
Zhe
Z
Qiao
Xiao-chun
XC
Li
Dong-min
DM
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000635:transmission*; D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000009:adverse effects; D015995:Prevalence; D012189:Retrospective Studies