GM1 ganglioside prevented the decline of hippocampal neurogenesis associated with D-galactose.
Hippocampal neurogenesis is thought to play a functional role in hippocampal-dependent learning and memory. The neurogenic capability of the hippocampus declines with age and may be associated with a decline in cognitive function. In the present study, an established model of ageing in mice was used to test the protective effects of GM1 ganglioside on hippocampal neurogenesis. This model uses D-galactose treatment to cause neuronal injury and reduced neurogenesis. GM1 significantly increased the proliferation, long-term survival and neuronal differentiation of hippocampal progenitors that had been injured with D-galactose. This study demonstrates that GM1 can protect hippocampal neurogenesis from D-galactose injury. Therefore, GM1 may protect neurogenesis in the ageing brain.
Zhang
Qing
Q
Department of Pharmacology, School of Basic Medicine, Peking Union Medical College and Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing 100005, China.
Huang
Yigang
Y
Li
Xuekun
X
Cui
Xu
X
Zuo
Pingping
P
Li
Jifeng
J
D000704:Analysis of Variance; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D000089622:Doublecortin Domain Proteins; D005677:G(M1) Ganglioside / Q000627:therapeutic use*; D005690:Galactose / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007150:Immunohistochemistry / Q000379:methods; D020287:In Situ Nick-End Labeling / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009410:Nerve Degeneration / Q000139:chemically induced / Q000517:prevention & control*; D009479:Neuropeptides / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011897:Random Allocation; D012038:Regeneration / Q000187:drug effects
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; C079240:Mtap2 protein, mouse; D009479:Neuropeptides; D018696:Neuroprotective Agents; D005677:G(M1) Ganglioside; D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine; D005690:Galactose