title: tRNA turnaround.
abstract: Two recently published papers (Takano et al., 2005 and Shaheen and Hopper, 2005) demonstrate that in S. cerevisiae, cytoplasmic tRNAs can be transported into the nucleus. This retrograde movement may expose mature tRNAs to nuclear proofreading or it may regulate tRNA availability in response to amino acid availability.
authors.affiliation: Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA.
authors.forename: James
authors.initials: J
authors.lastname: Dahlberg
authors.forename: Elsebet
authors.initials: E
authors.lastname: Lund
mesh_terms: D021581:Active Transport, Cell Nucleus; D000596:Amino Acids / Q000172:deficiency / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D008954:Models, Biological; D029543:Nucleocytoplasmic Transport Proteins / Q000378:metabolism; D012326:RNA Splicing; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D020931:ran GTP-Binding Protein / Q000378:metabolism
chemical_list: D000596:Amino Acids; C110033:MTR10 protein, S cerevisiae; D029543:Nucleocytoplasmic Transport Proteins; D012331:RNA, Fungal; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D012343:RNA, Transfer; D020931:ran GTP-Binding Protein