title: [TS-1 therapy via intestinal catheter used for tube feeding in a patient with gastric cancer after total gastrectomy].
abstract: The patient was a 76-year-old man having gastric cancer with peritoneal dissemination. He underwent total gastrectomy for resection of the primary tumor and improvement of the oral intake. He developed ileus and peritonitis after the surgery, which necessitated two additional operations. An intestinal stoma was thus therefore created using a catheter for tube feeding, and tube feeding was initiated after the surgery. Nutrients, as well as TS-1 (taken out of the capsule; 80 mg/day) were administered via the catheter for tube feeding. This therapy was followed by a reduction in tumor marker levels and improvement of the patient's performance status (PS), after which the patient could be discharged. He stayed at home for about 8 months, with a much-improved quality of life during this period. We concluded that the TS-1 therapy via the catheter used for alimentation was effective for the treatment of cancer in this patient. We report our experience with this case, in which tube feeding became necessary after total gastrectomy, but administration of TS-1 via the same catheter used for alimentation improved the patient's PS and made it possible for him to receive chemotherapy at home.
authors.affiliation: First Dept. of Surgery, Faculty of Medicine, Kagawa University.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hagiike
authors.forename: Yuka
authors.initials: Y
authors.lastname: Tsuboi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Akamoto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yachida
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Izuishi
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Karasawa
authors.forename: Fuminori
authors.initials: F
authors.lastname: Goda
authors.forename: Setsuo
authors.initials: S
authors.lastname: Okada
authors.forename: Hisashi
authors.initials: H
authors.lastname: Usuki
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeta
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002404:Catheterization; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004750:Enteral Nutrition / Q000295:instrumentation*; D005743:Gastrectomy; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary; D011725:Pyridines / Q000008:administration & dosage*; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid