Diterpenoids from the Chinese herb Caryopteris terniflora and their antibacterial and antitumor activity.
Two ent-kaurene type diterpenoids, diterpenoids A (1) and B (2) were isolated from the Chinese herb Caryopteris terniflora and defined as ent-7beta, 11alpha,14-trihydroxy-18-aldehyde-11beta-20-epoxy-kaur-16-en15-one and ent-7beta,14-dihydroxy-11alpha-methoxy-18-aldehyde-11beta-20-epoxy-kaur-16-en-15-one respectively. Compounds 1 and 2 showed significant antibacterial and antitumour activity.
Zhang
Yong-Hong
YH
Department of Pharmacy, Fujian Medical University, Fuzhou 350004, PR. China. zhangyh@mail.fjmu.edu.cn
Wang
Yan-Lin
YL
Wei
Qing-Yi
QY
Cai
Yu-Jun
YJ
Wang
Qin
Q
Liu
Zhong-Li
ZL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D029648:Verbenaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C503616:ent-7beta,11alpha,14-trihydroxy-18-aldehyde-11beta-20-epoxy-kaur-16-en15-one; C503614:ent-7beta,14-dihydroxy-11alpha-methoxy-18-aldehyde-11beta-20-epoxy-kaur-16-en-15-one