Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis.
Adhesion molecule mediated leukocyte migration into the central nervous system is considered to be a critical step in the pathogenesis of multiple sclerosis (MS). We measured plasma levels of the soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin in 166 MS patients and in 36 healthy blood donors with ELISA. sPECAM-1, sP-selectin and sE-selectin plasma concentrations showed a significant increase in the relapsing-remitting disease course of MS and were elevated during relapse. These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease.
Kuenz
Bettina
B
Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
Lutterotti
Andreas
A
Khalil
Michael
M
Ehling
Rainer
R
Gneiss
Claudia
C
Deisenhammer
Florian
F
Reindl
Markus
M
Berger
Thomas
T
D000328:Adult; D015815:Cell Adhesion Molecules / Q000097:blood*; D018450:Disease Progression; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000145:classification / Q000473:pathology; D019007:P-Selectin / Q000097:blood*
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019007:P-Selectin