title: Effect of aqueous extract from Nigella sativa L. on guinea pig isolated heart.
abstract: A potent inhibitory effect of aqueous extract from N. sativa on calcium channel of guinea pig heart was found comparable and even greater than that of diltazem. The results may also indicate an opening effect for the plant on potassium channel of isolated heart.
authors.affiliation: Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, 91735, Iran.
authors.forename: Mohammad Naser
authors.initials: MN
authors.lastname: Shafei
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Boskabady
authors.forename: Heydar
authors.initials: H
authors.lastname: Parsaee
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D031881:Nigella sativa; D010936:Plant Extracts / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D014867:Water
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D010936:Plant Extracts; D015221:Potassium Channels; D014867:Water; D004110:Diltiazem