title: Organochlorine contaminants in human adipose tissues from China: mass balance approach for estimating historical Chinese exposure to DDTs.
abstract: Concentrations of persistent organochlorines (OCs), such as DDTs, hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), polychlorinated biphenyls (PCBs), and chlordane compounds (CHLs) were determined in 34 human adipose tissues collected from Guizhou Province, southern China, during 2002. DDT was the predominant contaminant among OCs analyzed; concentrations ranged from 420 to 20 000 ng/g on a lipid wt basis (average +/- sd: 5700 +/- 4100 ng/g). Concentrations of DDTs and the ratio of p,p'-DDT/ sigmaDDT in humans in China were significantly higher than those reported for developed countries. DDT levels in humans in Guizhou Province were comparable to those from Shanghai City, implying the presence of significant sources of DDTs in inland and coastal areas in China. Age-dependent accumulation of HCH concentration was found in this study, possibly because of the considerable reduction in average dairy intake (ADI) of HCHs by Chinese during the recent two decades. On the basis of the information of the ADI rates, half-lives, and body burdens of DDTs, the magnitude of historical DDT exposures by Chinese was estimated. This suggested that approximately 80% of DDTs deposited in Chinese adipose tissues was accumulated before the 1990s. The monitoring of OC levels and epidemiological studies are needed in China to understand the status of contamination and the risks to humans.
authors.affiliation: Graduate School of Science and Technology, Kumamoto University 2-39-1 Kurokami, Kumamoto 860-8555 Japan. nakata@sci.kumamoto-u.ac.jp
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nasu
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Abe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitano
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: Fan
authors.forename: Weihua
authors.initials: W
authors.lastname: Li
authors.forename: Xucheng
authors.initials: X
authors.lastname: Ding
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China; D003634:DDT / Q000032:analysis / Q000266:history / Q000493:pharmacokinetics*; D004781:Environmental Exposure; D016021:Epidemiologic Studies; D005260:Female; D049673:History, 20th Century; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000266:history / Q000493:pharmacokinetics*; D007306:Insecticides / Q000032:analysis / Q000266:history / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged
chemical_list: D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D003634:DDT