Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats.
Tea has long been believed to be a healthy beverage, and its beneficial effects are almost all attributed to catechins. The effect of catechins on postprandial hypertriglyceridemia in rats was investigated in this study. A lipid emulsion administered orally to rats with (-)-epigallocatechin gallate at a dose of 100 mg/kg resulted in the increase in plasma triacylglycerol being significantly inhibited after 1 and 2 h compared to the case without (-)-epigallocatechin gallate. The effect of (-)-epigallocatechin was weaker than that of (-)-epigallocatechin gallate. A tea extract (THEA-FLAN 90S), mainly composed of catechins with a galloyl moiety, dose-dependently suppressed postprandial triacylglycerol after the administration of a lipid emulsion at doses of 50-200 mg/kg. The administration of the tea extract alone at a dose of 200 mg/kg had no effect on the plasma triacylglycerol level. These results strongly suggest that catechins with a galloyl moiety would be promising agents for suppressing dietary fat absorption through the small intestine.
Suzuki
Yuko
Y
Central Research Institute, ITO EN, LTD., Shizuoka 421-0516, Japan. yu-suzuki@itoen.co.jp
Unno
Tomonori
T
Kobayashi
Makoto
M
Nozawa
Ayumu
A
Sagesaka
Yuko
Y
Kakuda
Takami
T
D000818:Animals; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D015228:Hypertriglyceridemia / Q000097:blood / Q000517:prevention & control*; D008297:Male; D019518:Postprandial Period; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D013662:Tea; D014280:Triglycerides; D002392:Catechin; C057580:gallocatechol