title: Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'.
abstract: Although classical psychopathological studies have shown the presence of an independent diagnostic category, 'atypical psychosis', most psychotic patients are currently classified into two major diagnostic categories, schizophrenia and bipolar disorder, by the Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM-IV) criteria. 'Atypical psychosis' is characterized by acute confusion without systematic delusion, emotional instability, and psychomotor excitement or stupor. Such clinical features resemble those seen in organic mental syndrome, and differential diagnosis is often difficult. Because patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) sometimes show organic mental disorder, 'atypical psychosis' may be caused by mutations of mitochondrial DNA (mtDNA) in some patients. In the present study whole mtDNA was sequenced for seven patients with various psychotic disorders, who could be categorized as 'atypical psychosis'. None of them had known mtDNA mutations pathogenic for mitochondrial encephalopathy. Two of seven patients belonged to a subhaplogroup F1b1a with low frequency. These results did not support the hypothesis that clinical presentation of some patients with 'atypical psychosis' is a reflection of subclinical mitochondrial encephalopathy. However, the subhaplogroup F1b1a may be a good target for association study of 'atypical psychosis'.
authors.affiliation: Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan.
authors.forename: An-A
authors.initials: AA
authors.lastname: Kazuno
authors.forename: Kae
authors.initials: K
authors.lastname: Munakata
authors.forename: Kanako
authors.initials: K
authors.lastname: Mori
authors.forename: Masashi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nanko
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Kohda
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Akiyama
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Washizuka
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D017931:DNA Primers; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics*; D030561:Databases, Nucleic Acid; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics* / Q000523:psychology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D017931:DNA Primers; D004272:DNA, Mitochondrial