Dietary Garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake.
The influence of 3.3% Garcinia cambogia extract on the properties of mouse skin with or without 10% sucrose water loading was investigated. Mice (7-week-old) were given free access to a control diet or a diet containing Garcinia cambogia extract. They were also given water alone or both water and sucrose water. Their skin was compared by both biochemical and histological methods. The collagen and triacylglycerol contents were not significantly different among the four groups. Similarly, electron microscopy revealed no differences in the thickness of the dermis layer or the subcutaneous tissue layer. Mice given the diet containing Garcinia cambogia tended to have a reduced total number of adipocytes, but not significantly. These results suggest that Garcinia cambogia supplementation for at least 4 weeks does not induce a negative effect on skin properties in mice irrespective of excessive sucrose intake.
Oikawa
Daichi
D
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Hirakawa
Hachidai
H
Hayamizu
Kohsuke
K
Nakamura
Yoshinori
Y
Shiba
Nobuya
N
Nakanishi
Tomonori
T
Iwamoto
Hisao
H
Tachibana
Tetsuya
T
Furuse
Mitsuhiro
M
D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D029761:Garcinia cambogia; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D019440:Anti-Obesity Agents; D004040:Dietary Carbohydrates; D010936:Plant Extracts; D014280:Triglycerides; D013395:Sucrose; D003094:Collagen