title: Effects of modified low-density lipoproteins on human retinal pericyte survival.
abstract: According to a current paradigm cardiovascular diseases can be initiated by exposure of vascular cells to qualitatively modified low-density lipoproteins (LDL). Capillary leakage, an early feature of diabetic retinopathy, results in the exposure of retinal pericytes to modified LDL, including glycated (G-LDL) and heavily oxidized glycated LDL (HOG-LDL). We demonstrate here that modified LDL inhibits the proliferation and survival of cultured human retinal pericytes. Modified LDL also induced DNA fragmentation in bovine retinal pericytes. Overall, HOG-LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG-LDL could be implicated in the development of diabetic retinopathy.
authors.affiliation: Medicine Endocrinology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Song
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Barth
authors.forename: Kangmo
authors.initials: K
authors.lastname: Lu
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Yu
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Cynthia K
authors.initials: CK
authors.lastname: Gittinger
authors.forename: W Scott
authors.initials: WS
authors.lastname: Argraves
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Lyons
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival; D053938:DNA Fragmentation / Q000187:drug effects; D017127:Glycation End Products, Advanced; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D020286:Pericytes / Q000166:cytology* / Q000187:drug effects; D012160:Retina / Q000166:cytology*; D000093844:Glycated Proteins
chemical_list: D017127:Glycation End Products, Advanced; D008077:Lipoproteins, LDL; C031797:glycated lipoproteins, LDL; D000093844:Glycated Proteins