title: Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan.
abstract: In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1 -OHP-gluc was 0.117 micromol/mol creatinine in the exposed group and 0.073 micromol/mol creatinine in the reference group (difference in mean concentrations: 0.044 micromol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 micromol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 micromol/mol creatinine [95% Cl: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.
authors.affiliation: Department of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: Ching-Huang
authors.initials: CH
authors.lastname: Lai
authors.forename: Saou-Hsing
authors.initials: SH
authors.lastname: Liou
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Shih
authors.forename: Perng-Jy
authors.initials: PJ
authors.lastname: Tsai
authors.forename: Hsiao-Lung
authors.initials: HL
authors.lastname: Chen
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Buckley
authors.forename: Paul T
authors.initials: PT
authors.lastname: Strickland
authors.forename: Jouni J K
authors.initials: JJ
authors.lastname: Jaakkola
mesh_terms: D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003430:Cross-Sectional Studies; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D005965:Glucuronates / Q000652:urine*; D006801:Humans; D016273:Occupational Exposure; D011721:Pyrenes; D012907:Smoking / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology; D001335:Vehicle Emissions
chemical_list: C093851:1-hydroxypyrene-glucuronide; D000395:Air Pollutants, Occupational; D015415:Biomarkers; D005965:Glucuronates; D011721:Pyrenes; D001335:Vehicle Emissions