title: Severe acute enteritis in a multiple myeloma patient receiving bortezomib and spinal radiotherapy: case report.
abstract: Proteasome inhibitors have been reported to enhance radiosensitivity in vitro. A case of potential clinical interaction between bortezomib, a proteasome inhibitor, and spine radiation is reported. A woman undergoing palliative radiotherapy to the T12 -S2 spine with concurrent bortezomib developed unexpectedly severe, acute radiation enteritis requiring hospital admission. Clinicians are advised to consider the potential for interactions of bortezomib with radiotherapy when the two agents are used simultaneously in the clinic.
authors.affiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. mmohiuddin@partners.org
authors.forename: M M
authors.initials: MM
authors.lastname: Mohiuddin
authors.forename: D C
authors.initials: DC
authors.lastname: Harmon
authors.forename: T F
authors.initials: TF
authors.lastname: Delaney
mesh_terms: D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001897:Boronic Acids / Q000009:adverse effects* / Q000627:therapeutic use*; D000069286:Bortezomib; D003131:Combined Modality Therapy; D004751:Enteritis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000532:radiotherapy*; D010166:Palliative Care; D011719:Pyrazines / Q000009:adverse effects* / Q000627:therapeutic use*; D011832:Radiation Injuries; D013125:Spinal Neoplasms / Q000532:radiotherapy*
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib