title: A study on trend of relapse in leprosy and factors influencing relapse.
abstract: A retrospective analysis of data pertaining to the rural field operation area of the Central Leprosy Teaching and Research Institute, Chengalpattu, Tamil Nadu, was carried out to determine the magnitude of relapse after MDT and its significance with other variables. The study included 3248 leprosy patients who have successfully completed treatment during 1987-2003, of whom 2892 were PB and 356 MB cases. A total of 58 cases of relapse was reported which gives a crude cumulative relapse rate of 1.78% for the 16-year period of follow-up and the rates for PB and MB were 1.9% and 0.84% respectively. With respect to PB cases, 68% of relapses were reported in the first 3 years of RFT. The person-year relapse rate was highly significant with regard to the number of skin lesions (p<0.0002) and nerve involvement (p<0.0002). The person-year relapse rate did not differ significantly between PB and MB leprosy, male and female, and child and adult cases. RFT year cohort relapse rate reveals that the introduction of MB-MDT regimen for PB leprosy had resulted in the reduction of relapses among PB cases after 1998. The relapse rate with reference to the time gap after RFT reveals that relapse declines with passage of time after RFT. The risk of relapse was very low in both PB and MB leprosy which fact emphasizes that proper counselling about signs and symptoms of relapse during RFT is adequate to combat the problem. A majority of relapses occurred in the first three years after RFT. The number of skin lesions and involvement of nerves were the main risk factors for relapse.
authors.affiliation: Division of Epidemiology and Statistics, Central Leprosy Teaching and Research Institute (CLTRI), Chengalpattu 603 001, Tamil Nadu.
authors.forename: M K Showkath
authors.initials: MK
authors.lastname: Ali
authors.forename: D M
authors.initials: DM
authors.lastname: Thorat
authors.forename: M
authors.initials: M
authors.lastname: Subramanian
authors.forename: G
authors.initials: G
authors.lastname: Parthasarathy
authors.forename: U
authors.initials: U
authors.lastname: Selvaraj
authors.forename: V
authors.initials: V
authors.lastname: Prabhakar
mesh_terms: D000328:Adult; D002648:Child; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007194:India; D007917:Leprostatic Agents / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy*; D016015:Logistic Models; D008297:Male; D008911:Minocycline / Q000627:therapeutic use; D015999:Multivariate Analysis; D009166:Mycobacterium leprae / Q000254:growth & development*; D015242:Ofloxacin / Q000627:therapeutic use; D012008:Recurrence; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use; D012424:Rural Population
chemical_list: D007917:Leprostatic Agents; D015242:Ofloxacin; D008911:Minocycline; D012293:Rifampin