Chromosome 1p loss: a favorable prognostic factor in low-grade gliomas.
Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor (EGFR) gene amplification, and p53 expression was performed in a series of 131 low-grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression-free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression-free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low-grade gliomas.
Kujas
Michèle
M
INSERM U711 et Université Pierre et Marie Curie Paris VI, France.
Lejeune
Julie
J
Benouaich-Amiel
Alexandra
A
Crinière
Emmanuelle
E
Laigle-Donadey
Florence
F
Marie
Yannick
Y
Mokhtari
Karima
K
Polivka
Marc
M
Bernier
Michèle
M
Chretien
Fabrice
F
Couvelard
Anne
A
Capelle
Laurent
L
Duffau
Hugues
H
Cornu
Philippe
P
Broët
Philippe
P
Thillet
Joëlle
J
Carpentier
Antoine F
AF
Sanson
Marc
M
Hoang-Xuan
Khê
K
Delattre
Jean-Yves
JY
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology / Q000379:methods