SNAREs and traffic.
SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now generally accepted to be the major players in the final stage of the docking and the subsequent fusion of diverse vesicle-mediated transport events. The SNARE-mediated process is conserved evolutionally from yeast to human, as well as mechanistically and structurally across different transport events in eukaryotic cells. In the post-genomic era, a fairly complete list of "all" SNAREs in several organisms (including human) can now be made. This review aims to summarize the key properties and the mechanism of action of SNAREs in mammalian cells.
Hong
Wanjin
W
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Sinapore, Singapore. mcbhwj@imcb.a-star.edu
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D005089:Exocytosis; D005786:Gene Expression Regulation; D006801:Humans; D008561:Membrane Fusion; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D050600:SNARE Proteins; D017386:Sequence Homology, Amino Acid; D033921:Vesicular Transport Proteins / Q000737:chemistry* / Q000502:physiology*
D050600:SNARE Proteins; D033921:Vesicular Transport Proteins