title: Prolonged QT interval in pediatric sickle cell disease.
abstract: We recently cared for a patient with sickle cell disease (SCD) who presented with cardiac arrest and was found to have a prolonged corrected QT interval (QTc). This prompted us to perform a retrospective review of all electrocardiograms performed in patients with SCD during the last two years. Among 142 patients with ECG results, we identified 12 patients (8 males and 4 females), who had one or more documented measurements of prolonged QTc intervals. The relatively high prevalence of borderline or moderately prolonged QTc intervals in our patient population warrants further investigation.
authors.affiliation: Baylor College of Medicine, Houston, TX 77030-4215, USA. bumuelle@txccc.org
authors.forename: Brigitta U
authors.initials: BU
authors.lastname: Mueller
authors.forename: Kahlil J
authors.initials: KJ
authors.lastname: Martin
authors.forename: William
authors.initials: W
authors.lastname: Dreyer
authors.forename: Louis I
authors.initials: LI
authors.lastname: Bezold
authors.forename: Donald H
authors.initials: DH
authors.lastname: Mahoney
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006801:Humans; D008133:Long QT Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity