title: A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results.
abstract: The subproject 1.5 "Neurobiology of Suicidal Behavior" is a multicenter study assessing peripheral parameters of the serotonergic, noradrenergic, and dopaminergic transmitter systems. Additionally, stress hormones and the lipid system as well as inhibitory and excitatory amino acids will be investigated. The different parameters are collected in cerebral spinal fluid (CSF), blood, and saliva. Patients with a depressive spectrum disorder with and without a suicide attempt (during the last three weeks) and being medication free for two weeks are included in the study. So far, 103 patients and controls have been recruited. The design and development of this project as well as interconnections with the others subprojects are described. Preliminary results about the stress hormone system and suicidality are presented.
authors.affiliation: Max-Planck Institute of Psychiatry, Munich, Germany. bronisch@mpipsykl.mpg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Bronisch
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brunner
authors.forename: Brigitta
authors.initials: B
authors.lastname: Bondy
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: Gerd
authors.initials: G
authors.lastname: Bishof
authors.forename: Isabella
authors.initials: I
authors.lastname: Heuser
authors.forename: Bruno
authors.initials: B
authors.lastname: Müller-Oerlinghausen
authors.forename: Barbara
authors.initials: B
authors.lastname: Hawellek
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Marie Luise
authors.initials: ML
authors.lastname: Rao
authors.forename: Werner
authors.initials: W
authors.lastname: Felber
authors.forename: Ute
authors.initials: U
authors.lastname: Lewitzka
authors.forename: Jochen
authors.initials: J
authors.lastname: Oehler
authors.forename: Andreas
authors.initials: A
authors.lastname: Broocks
authors.forename: Fritz
authors.initials: F
authors.lastname: Hohagen
authors.forename: Erik
authors.initials: E
authors.lastname: Lauterbach
mesh_terms: D000374:Aggression / Q000523:psychology; D001007:Anxiety / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007175:Impulsive Behavior / Q000523:psychology; D050356:Lipid Metabolism; D008995:Monoamine Oxidase / Q000097:blood; D009638:Norepinephrine / Q000378:metabolism; D011446:Prospective Studies; D012701:Serotonin / Q000378:metabolism*; D013406:Suicide, Attempted / Q000208:ethnology* / Q000523:psychology*
chemical_list: D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine