title: The significance of clinical markers in the prediction of hemodynamic and cardiac complications of capnoperitoneum in patients at risk.
abstract: OBJECTIVE
  The aim of this prospective study was to find out the predictive value of concomitant diseases of cardiovascular system (CVS), lungs and kidneys as well as metabolic diseases to be able to anticipate the potential origin of hemodynamic and cardiopulmonary complications as a result of insufflated CO2 peritoneum.
  
  
  METHODS
  The study investigated eleven patients at the anaesthetic risk of ASA III-IV and cardiac risk of NYHA II-III in whom elective laparoscopic surgical intervention had been indicated.
  
  
  RESULTS
  We have found out that the significance of the increase in biologic ANP markers, catecholamines and PRA was not sufficient to signal the deepening of cardiac dysfunction, latent cardiac failure or hemodynamic disorder (p > 0.01). The courses of regression lines have shown the dependence on the increased IAP (intra-abdominal pressure) of capnoperitoneum in PRA and adrenaline. The reactions of biologic markers correlated with reactions of clinical hemodynamic markers of BP and HR. We have proved that the increased level of IAP causes a significant increase in CVP (p < 0.01) being one of the factors determining the preload of right ventricle (RV) and in coincidence with intact transpulmonary circulation also the optimal function of left ventricle (LV).
  
  
  CONCLUSIONS
  Our investigation of peroperative clinical and biologic markers of hemodynamics and neuroendocrine response to operative stress and development of CO2 peritoneum has proved that the course of laparoscopic operations in patients in the risk group of ASA III-IV and NYHA III does not necessarily have to be deteriorated by complications. It can be assumed that increased values of biologic markers regulate the neurohumoral response in the physiologic range and do not predict a severe CVS dysfunction within its course. (Tab. 2, Fig. 3, Ref. 22.)
authors.affiliation: Department of Surgery, Jessenius Faculty of Medicine, Comenius University and Martinus University Hospital, Martin, Slovakia. jan92@post.sk
authors.forename: J
authors.initials: J
authors.lastname: Janik
authors.forename: L
authors.initials: L
authors.lastname: Sutiak
authors.forename: R
authors.initials: R
authors.lastname: Pullmann
authors.forename: M
authors.initials: M
authors.lastname: Lojdlova
authors.forename: D
authors.initials: D
authors.lastname: Mistuna
authors.forename: A
authors.initials: A
authors.lastname: Mikolajcik
mesh_terms: D000005:Abdomen; D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002245:Carbon Dioxide; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology; D002395:Catecholamines / Q000097:blood; D006439:Hemodynamics; D006801:Humans; D010535:Laparoscopy; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D011312:Pressure; D012083:Renin / Q000097:blood; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002395:Catecholamines; D002245:Carbon Dioxide; D009320:Atrial Natriuretic Factor; D012083:Renin