title: Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature.
abstract: Primary angiosarcoma of the spleen is a very rare neoplasm with a poor prognosis. The definitive diagnosis is usually based on the histologic evaluation of the splenectomy specimen. We describe a case of angiosarcoma diagnosed by fine-needle aspiration cytology prior to splenectomy. A 69-year-old white woman presented with heterogeneous lesions in the spleen during a follow-up computed tomographic scan for a history of liposarcoma of the right buttock. A malignant endothelial neoplasm was diagnosed by fine-needle aspiration cytology using immunocytochemistry, and a splenectomy confirmed the presence of angiosarcoma. To our knowledge, this is the first well-documented and confirmed case of primary angiosarcoma of the spleen diagnosed by fine-needle aspiration cytology. This report emphasizes the value of fine-needle aspiration cytology as an important diagnostic tool in splenic neoplasms.
authors.affiliation: Department of Pathology, University of Miami School of Medicine, Miami, FL 33136, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Delacruz
authors.forename: Merce
authors.initials: M
authors.lastname: Jorda
authors.forename: Carmen
authors.initials: C
authors.lastname: Gomez-Fernandez
authors.forename: Pasquale
authors.initials: P
authors.lastname: Benedetto
authors.forename: Parvin
authors.initials: P
authors.lastname: Ganjei
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D004730:Endothelium, Vascular / Q000737:chemistry / Q000473:pathology; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006394:Hemangiosarcoma / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII