[Sensitivity of nanoparticlized cefazolin sodium to the bacteria in vitro].
OBJECTIVE
To investigate whether the in vitro sensitivity of cefazolin sodium to the bacteria was altered after nanoparticlization.


METHODS
The minimal inhibitory concentrations (MIC) of cefazolin sodium before and after nanoparticlization to S. aureaus and E. coli. were determined by microdilution.


RESULTS
The MIC of nanoparticlized cefazolin sodium to S. aureaus and E. coli. had no significant change compared with that of non-nanoparticlized one.


CONCLUSIONS
Nanoparticlization will not decrease the sensitivity of cefazolin sodium to the bacteria.
Zou
Long
L
Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China.
Fan
Xue-Gong
XG
Gui
Hui
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D049329:Nanostructures; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002437:Cefazolin