title: Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses.
abstract: In two studies, six healthy adult horses were given imipenem-cilastatin by slow intravenous (i.v.) infusion at an imipenem dosage of 10 mg/kg (study 1) and 20 mg/kg (study 2). The same horses were used in each dosage schedule, with a 2-week washout period between studies. In each dosage group, serial blood and synovial fluid samples were collected for 6 h after completion of the infusion. HPLC was used to determine the imipenem concentration in all samples. Imipenem was well tolerated by all horses at both dosages; no adverse effects were noted during the study period or during the 24-hour postinfusion observation period. The pharmacokinetic profiles of imipenem in the plasma and synovial fluid indicate that an imipenem dosage of 10-20 mg/kg by slow i.v. infusion q6h (every 6 h) is appropriate for most susceptible pathogens.
authors.affiliation: Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, PA 19348, USA. orsini@vet.upenn.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Orsini
authors.forename: P J
authors.initials: PJ
authors.lastname: Moate
authors.forename: R C
authors.initials: RC
authors.lastname: Boston
authors.forename: T
authors.initials: T
authors.lastname: Norman
authors.forename: J
authors.initials: J
authors.lastname: Engiles
authors.forename: C E
authors.initials: CE
authors.lastname: Benson
authors.forename: R
authors.initials: R
authors.lastname: Poppenga
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D015377:Cilastatin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006736:Horses / Q000378:metabolism*; D015378:Imipenem / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D007262:Infusions, Intravenous / Q000662:veterinary; D008826:Microbial Sensitivity Tests; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination