Recent progress in protein farnesyltransferase inhibition.
This review aims to provide a recent update on protein farnesyltransferase inhibition, covering the period 1999 to mid 2000. A brief overview of the project rationale and its most recent evolution is also presented. For each inhibitor series, the most advanced molecules are presented along with a short description of the patent environment, focusing on second generation patents that cover new applications for protein farnesyltransferase inhibitors (PFTIs).
Lamothe
M
M
Division de Chimie Médicinale IV, Centre de Recherche Pierre Fabre, 81106 Castres, Cédex 06, France. marie.lamothe@pierre-fabre.com
Perez
M
M