Childhood respiratory infections and hospital admissions for COPD.
BACKGROUND
Chronic Obstructive Pulmonary Disease (COPD) exacerbations are associated with viral infections. We wished to determine if respiratory viral infection of children in the community was associated with hospital admissions of patients with exacerbations of COPD.


METHODS
We collected data over a 45-month period from the Northern Ireland Regional Virus Laboratory and from a general hospital in the same locality. We studied the relationship between upper respiratory infections in children and COPD admissions. We also examined the role of school holidays.


RESULTS
Correlations were seen between the frequency of all viral infections in children and the number of adult COPD hospitalizations (P<0.005). Subgroup analysis showed distinct relationships with epidemics of; influenza A (P<0.001), influenza B (P<0.05), adenovirus (P=0.05), respiratory syncytial virus (P<0.005) and hospital admissions of patients with COPD. There were significantly fewer COPD admissions in the week after the start of a school holiday period (P<0.05).


CONCLUSIONS
When children are hospitalized with viral respiratory infection there is an associated rise in adult COPD admissions. This suggests exacerbations of COPD are associated with epidemics of respiratory viruses. When children are on school holidays there is a reduction in COPD admissions in the community. This provides further support for respiratory viruses in the pathogenesis of COPD exacerbations.
McManus
T E
TE
Department of Respiratory Medicine, Mater Hospital, Belfast BT14 6AB, UK. TerryMcManus@doctors.org.uk
Coyle
P V
PV
Kidney
J C
JC
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006693:Holidays; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009660:Northern Ireland / Q000453:epidemiology; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000821:virology; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology