Middle infrared, quantum cascade laser optoelectronic absorption system for monitoring glucose in serum.
Advances in middle infrared technology are leading researchers beyond the Fourier transform infrared spectrometer and to the quantum cascade laser. While most research focuses on gas-phase detection, recent research explores its use for condensed-phase matter studies. This work investigates its use for monitoring biologically relevant samples of glucose in serum. Samples with physiological glucose concentrations were monitored with a laser at 1036 cm-1. A 0.992 R2 linearity value was observed. In addition, using another laser at 1194 cm-1 as a measure of the background spectroscopic characteristics, a linearity of 0.998 R2 was observed. The average predictive standard errors of the mean (SEM) were 32.5 and 24.7 mg/dL, respectively, for each method. Quantum cascade lasers could be used to develop middle infrared devices for uses beyond the confines of the laboratory.
Martin
W Blake
WB
University of Alabama at Birmingham, Department of Biomedical Engineering, 1075 13th St. S, Suite 370, AL 35294, USA. bmartin@medicraft.com
Mirov
Sergey
S
Venugopalan
Ramakrishna
R
D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation* / Q000379:methods; D004582:Electronics, Medical; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007834:Lasers; D055095:Optics and Photonics / Q000295:instrumentation*; D011789:Quantum Theory; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods
D001786:Blood Glucose