title: Azadirachtin derivatives from seed kernels of Azadirachta excelsa.
abstract: Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11alpha-azadirachtin H (7), 11beta-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa. Their structures were established by spectroscopic techniques, and the structure of 3 was confirmed by X-ray analysis. Compounds 1-7 and 9 exhibited toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 0.75-1.92 microg/g body weight, in 92 h.
authors.affiliation: Department of Chemistry, Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. somdej@kku.ac.th
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.forename: Thirada
authors.initials: T
authors.lastname: Prajuabsuk
authors.forename: Sanha
authors.initials: S
authors.lastname: Panichajakul
authors.forename: Piyanan
authors.initials: P
authors.lastname: Panyamee
authors.forename: Samran
authors.initials: S
authors.lastname: Prabpai
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
mesh_terms: D000818:Animals; D031601:Azadirachta / Q000737:chemistry*; D018360:Crystallography, X-Ray; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009036:Moths / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013785:Thailand
chemical_list: D036701:Limonins; C010329:azadirachtin