title: The medium-term results of treatment with hydroxyapatite implants.
abstract: Although the short-term results of implants with synthetic hydroxyapatite (HA), a bioactive material, have been favorable, few reports have been published concerning medium-term outcomes for this therapy. The authors recently analyzed data supplied by 37 medical facilities nationwide concerning the outcomes of synthetic HA implants [Bonfil (BF); Mitsubishi Materials Corporation, Tokyo] in 138 patients followed up for at least 5 years after treatment. When the data were analyzed, the patients were divided into two groups: the disease site-filling group (62 cases where bone defects created by disease were filled with synthetic HA) and the donor site-filling group (76 cases where bone defects created by bone donation were filled with synthetic HA). In the disease site-filling group, synthetic HA was used in combination with autologous bone or autogenous bone marrow donated from the same patient in 77% of cases. In the donor site-filling group, only synthetic HA was used in most cases. The average follow-up period after implantation was 7.9 years in the disease site-filling group and 9.1 years in the donor site-filling group. Therapy was rated radiographically as "very effective" or "effective" in 81% of patients in the disease site-filling group and in 89% of patients in the donor site-filling group. The therapy was not rated as "ineffective" in any case from either group. These results suggest that synthetic HA may serve as a very useful substitute for cancellous bone if used carefully, with its initial strength taken into account.
authors.affiliation: Koga Clinic of Orthopedic Surgery, 3-30-4, Higashiogu, Arakawa-ku, Tokyo, 116-0012, Japan. kaz-shibuya-03@m2.pbc.ne.jp
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shibuya
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kurosawa
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Niwa
mesh_terms: D000077:Acetabulum / Q000002:abnormalities / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017824:Bone Cysts, Aneurysmal / Q000175:diagnosis / Q000601:surgery; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus / Q000473:pathology / Q000601:surgery; D007085:Ilium / Q000473:pathology / Q000601:surgery; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged
chemical_list: D018786:Bone Substitutes; D017886:Durapatite