title: Warthin's tumour and smoking.
abstract: OBJECTIVE
  In an evaluation of our patients with parotid gland neoplasms, we noticed that patients with a Warthin's tumour were heavy smokers. The aim of this study was to confirm earlier findings in the literature concerning a possible association between smoking and the development of a Warthin's tumour.
  
  
  METHODS
  A case control study was performed using the clinical records and discharge letters of all consecutive patients with a Warthin's tumour in the pathology database of our hospital covering the last 15 years. Patients with a pleomorphic adenoma and a group of patients visiting our audiology department were used as controls.
  
  
  RESULTS
  A smoking history was found in 97.5% of the patients with a Warthin's tumour. Of the patients with a pleomorphic adenoma, 59% had a smoking history; 56.5% of the audiology group had a smoking history. Mean age at the time of the operation was 60.1 years of age in the Warthin's tumour group and 48.6 for the pleomorphic adenoma group.
  
  
  CONCLUSIONS
  The mean age for the development of a Warthin's tumour is ten years older than for a pleomorphic adenoma. Furthermore, the development seems to be closely related to smoking habits.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University Medical Centre, Utrecht, Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: de Ru
authors.forename: R F
authors.initials: RF
authors.lastname: Plantinga
authors.forename: M H J M
authors.initials: MH
authors.lastname: Majoor
authors.forename: P P G
authors.initials: PP
authors.lastname: van Benthem
authors.forename: P J
authors.initials: PJ
authors.lastname: Slootweg
authors.forename: P H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: G J
authors.initials: GJ
authors.lastname: Hordijk
mesh_terms: D000235:Adenolymphoma / Q000209:etiology*; D008949:Adenoma, Pleomorphic / Q000209:etiology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000209:etiology*; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D013997:Time Factors