Ontogeny of hematological cell and biochemical profiles in maternal and fetal baboons (Papio species).
The normal ranges of hematological cell profiles and biochemistry are documented in adult non-pregnant, pregnant, juvenile, and neonatal baboons. Despite the extensive use of the baboon as a model for the study of various aspects of pregnancy, there is no data from paired mothers and their fetuses at different stages of gestation. Hematologic and biochemical profile data were obtained from eight non-pregnant female baboons, 37 mothers and 38 fetal baboons at 30 +/- 2, 90 +/- 2, 125 +/- 2, and 175 +/- 2 days of gestation (mean +/- range; dGA; term, 180 dGA). Changes observed in fetal and maternal blood during normal baboon pregnancy were similar to those reported in human pregnancy. The level of alkaline phosphatase was two times higher in fetal blood circulation than that reported in human pregnancy.
Schlabritz-Loutsevitch
Natalia E
NE
Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227-5301, USA. nschlabr@icarus.sfbr.org
Hubbard
Gene B
GB
Jenkins
Susan L
SL
Martin
Helen C
HC
Snider
Cathy S
CS
Frost
Patrice A
PA
Leland
M Michelle
MM
Havill
Lorena M
LM
McDonald
Thomas J
TJ
Nathanielsz
Peter W
PW
D000818:Animals; D000831:Animals, Newborn; D001772:Blood Cell Count / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary; D001835:Body Weight / Q000502:physiology; D002585:Cesarean Section / Q000662:veterinary; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D010215:Papio / Q000097:blood* / Q000196:embryology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*