Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8.
We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14-18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.
Hosoi
Toru
T
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.
Okuma
Yasunobu
Y
Ono
Atsushi
A
Nomura
Yasuyuki
Y
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D017931:DNA Primers; D020738:Leptin / Q000494:pharmacology*; D051379:Mice; D010766:Phosphorylation
D017931:DNA Primers; D020738:Leptin