title: Molecular remodeling in the failing human heart.
abstract: Heart failure is a progressive and fatal disease process. Arrhythmias and progressive cardiac dysfunction account for most of the morbidity and mortality in patients with heart failure. In general, the physiologic mechanisms responsible for progressive myocyte dysfunction, remodeling, and arrhythmias involve signaling mechanisms that alter myocardial gene expression. These changes in gene expression are complex and involve contractile proteins, ion channels, Ca++ handling, apoptosis, cell metabolism, the extracellular matrix, signal transduction pathways, and growth factors.
authors.affiliation: Division of Cardiology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Campus Box B139, Denver, CO 80262, USA.
authors.forename: DeeAnn M
authors.initials: DM
authors.lastname: Rivera
authors.forename: Brian D
authors.initials: BD
authors.lastname: Lowes
mesh_terms: D000200:Action Potentials; D018450:Disease Progression; D015870:Gene Expression; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D032342:Muscle Cells / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D015221:Potassium Channels / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D015221:Potassium Channels