title: Designing trials and deciding on therapy in complex diseases: what can we do to improve?
authors.affiliation: Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA 22908-0717, USA. wknaus@virginia.edu
authors.forename: William A
authors.initials: WA
authors.lastname: Knaus
mesh_terms: D018806:APACHE; D002986:Clinical Trials as Topic; D012107:Research Design; D013812:Therapeutics; D014481:United States; D014486:United States Food and Drug Administration