title: [Two-stage administration sedation method for gastroscopy in hypoxia predisposed patients].
abstract: OBJECTIVE
  To explore the safety and the efficacy of two-stage administration sedation method (with propofol plus midazolam) in the analgesia gastroscopy for hypoxia predisposed patients.
  
  
  METHODS
  Sixty-four hypoxia predisposed patients (with snore or expectoration) were divided into two groups and received sedation respectively with two-stage administration method and routine continuum administration method before gastroscopy. We analyzed the alteration of SBP, DBP, SpO2, sedation level, the degree of pharyngeal malaise, recovery time, dose of propofol,the lethe degree of upset, and procedure of gastroscopy to evaluate the safety and the efficacy of the two methods in the analgesia gastroscopy for hypoxia predisposed patients.
  
  
  RESULTS
  Compared with routine continuum administration sedation method, two-stage administration sedation method had little influence on SpO2, so it reduced the accident of respiratory arrest (P < 0.01). The gastroscopy could be achieved at the lower sedation level with two stage administration method (P <0.01), so that the recovery time was shortened (P < 0.01). The degree of pharyngeal malaise in the patients with two-stage administration sedation method was higher than that of patients with routine continuum administrationsedation method (P < 0.01), and the dose of propofol used for sedation decreased (P < 0.01). While the lethe degree of gastroscopy upset and alteration of SBP, DBP were rated similarly in both groups (P > 0.05), and the lethe degree of gastroscopy procedure in two-stage administration method group was significantly lower than that of routine continuum adminis- tration method group (P <0.01).
  
  
  CONCLUSIONS
  The two-stage administration sedation method is a new effective and safe sedation method for gastroscopy in the hypoxia predisposed patients.
authors.affiliation: Department of Digestion, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.forename: Ding-Hua
authors.initials: DH
authors.lastname: Xiao
authors.forename: Shou-Rong
authors.initials: SR
authors.lastname: Shen
mesh_terms: D000328:Adult; D000698:Analgesia; D005260:Female; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol