[State of the endothelial system and expression of tissue hypoxia in children with bronchial asthma of atopic geneses].
In investigation were included 33 children with mild and moderate bronchial asthma of atopic geneses, average duration of the disease 3,5+/-1,9 years, average frequency of asthma attacks was less then once per month (night attacks 2-3 times per week), factors of initiation were dust and sharp smells. It was shown, that in atopic bronchial asthma in children, disbalance in endothelial system is developed, the content of endothelin-1, vasoconstrictor peptide of endotheliocytes, is increased by 64%. At the same time, coefficient of correlation between redox-potential NADP/NADPH and content of IgE decreases from 0,79 (p<0,01) in norm to 0,57 (p<0,05). Obtained data raises the issue of necessity of inclusion in the therapy of bronchial asthma the remedies which prevent bioenergetic failure.
Barbakadze
T R
TR
Acad. N.V. Karsanov Republican Centre of Medical Biophysics and Introduction of New Biomedical Technologies, Tbilisi State Medical University, Georgia.
Garakanidze
I G
IG
Mamuchishvili
I G
IG
Tatulashvili
D R
DR
D001249:Asthma / Q000209:etiology* / Q000276:immunology / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications* / Q000276:immunology / Q000378:metabolism*; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D007070:Immunoglobulin A / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D010084:Oxidation-Reduction; D012867:Skin / Q000098:blood supply* / Q000378:metabolism* / Q000503:physiopathology
D019332:Endothelin-1; D007070:Immunoglobulin A; D007073:Immunoglobulin E