JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).
Luckman
Steven P
SP
Hughes
David E
DE
Coxon
Fraser P
FP
Russell
Graham G
GG
Rogers
Michael J
MJ
D000818:Animals; D001862:Bone Resorption / Q000266:history* / Q000378:metabolism; D002478:Cells, Cultured; D004164:Diphosphonates / Q000266:history* / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000266:history / Q000378:metabolism; D049673:History, 20th Century; D008148:Lovastatin / Q000031:analogs & derivatives / Q000266:history / Q000494:pharmacology; D008798:Mevalonic Acid / Q000266:history* / Q000378:metabolism; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D017368:Protein Prenylation / Q000187:drug effects; D018631:ras Proteins / Q000266:history* / Q000378:metabolism
D004164:Diphosphonates; C012258:mevastatin; D008148:Lovastatin; D019204:GTP-Binding Proteins; D018631:ras Proteins; D008798:Mevalonic Acid