A rapid synthesis of hexofuranose-like iminosugars using ring-closing metathesis.
Two new 1-N-iminosugars have been prepared as hexofuranose analogues in an efficient manner by an RCM-based route. Both 3,4-disubstituted pyrrolidines display moderate inhibitory activity against Mycobacterium smegmatis galactan biosynthesis. [structure: see text]
Cren
Sylvaine
S
School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
Wilson
Claire
C
Thomas
Neil R
NR
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002236:Carbohydrate Conformation; D003500:Cyclization; D005685:Galactans / Q000096:biosynthesis / Q000378:metabolism; D050113:Imino Furanoses / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005685:Galactans; D050113:Imino Furanoses