Association between the Ser128Arg variant of the E-selectin and risk of coronary artery disease in the central China.
BACKGROUND
The E-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of coronary atherosclerosis. It has been suggested that a S/R (Ser128Arg) polymorphism of E-selectin might be associated with the predisposition to coronary artery disease (CAD). Our purpose was to determine whether this S/R polymorphism influences the risk of CAD in Chinese patients.


RESULTS
We studied the human E-selectin gene polymorphism in a Chinese population by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). This polymorphism was determined in 248 CAD patients and in 256 control subjects. Frequencies of the SS, SR, and RR genotypes were found as 86.7%, 13.3%, and 0.0% in CAD patients and 93.8%, 6.2%, and 0.0% in control subjects, respectively. Frequency of the R allele was higher among CAD patients compared to controls(6.7% vs. 3.1%). However, either the genotype or the allele distribution of Ser128Arg polymorphism of E-selectin was statistically significantly different between the two groups (P<0.05). The odds ratio for the risk of CAD associated with the R allele was 2.21 (CI95%:1.20-4.07).


CONCLUSIONS
These results suggest that the SR genotype of the E-selectin gene polymorphism in codon 128 is a genetic factor that may determine an individual's susceptibility for CAD in Chinese.
Li
Yan
Y
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, People's Republic of China. yanlitf@hotmail.com
Wei
Ye-Sheng
YS
Wang
Ming
M
Zhang
Ping-An
PA
Jiang
Xue-Jun
XJ
Huang
Cong-Xin
CX
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D019040:E-Selectin / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012189:Retrospective Studies; D012307:Risk Factors
D019040:E-Selectin; D005819:Genetic Markers; D004247:DNA