Diagnostic utility of the subjective peripheral neuropathy screen in HIV-infected persons with peripheral sensory polyneuropathy.
A retrospective analysis of the Johns Hopkins University HIV neurology database was performed to assess the sensitivity and specificity of the Subjective Peripheral Neuropathy Screen (SPNS) for detecting HIV-associated neuropathies. The SPNS, a 3-item scale that evaluates lower extremity neuropathic symptoms, was administered to 75 patients from the HIV neurology outpatient clinic. Patients graded the severity of each symptom on a scale of 1 to 10, and the sensitivity, specificity, and diagnostic efficiency of the SPNS were calculated for each symptom. The results showed that the SPNS had a sensitivity of 47%, a specificity of 83%, a positive predictive value of 70%, and a diagnostic efficacy of 67%. The SPNS appears to be a useful screening tool for HIV-associated sensory neuropathies; it has a high specificity and a good positive predictive value.
Venkataramana
Anita B
AB
Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
Skolasky
Richard L
RL
Creighton
Jason A
JA
McArthur
Justin C
JC
D000328:Adult; D000553:Ambulatory Care; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D006987:Hypesthesia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009462:Neurology / Q000379:methods*; D010146:Pain / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D011115:Polyneuropathies / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D011795:Surveys and Questionnaires