title: Phytochemical and pharmacological study of Sedum dendroideum leaf juice.
abstract: The fresh juice from leaves of Sedum dendroideum Moc & Sessé (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1-1g/kg) of the lyophilized Sedum dendroideum juice (L J) caused a significant dose-related reduction of acetic acid-induced writhing response (ID(50)=631 mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1g/kg) in mice. In the formalin-induced nociception in mice, L J (1g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum.
authors.affiliation: Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21 941-590 Rio de Janeiro, RJ, Brazil.
authors.forename: Giany O
authors.initials: GO
authors.lastname: De Melo
authors.forename: David do C
authors.initials: Ddo C
authors.lastname: Malvar
authors.forename: Frederico A
authors.initials: FA
authors.lastname: Vanderlinde
authors.forename: Priscilla A
authors.initials: PA
authors.lastname: Pires
authors.forename: Wellington S
authors.initials: WS
authors.lastname: Côrtes
authors.forename: Pedro Germano
authors.initials: PG
authors.lastname: Filho
authors.forename: Michelle F
authors.initials: MF
authors.lastname: Muzitano
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Kaiser
authors.forename: Sônia S
authors.initials: SS
authors.lastname: Costa
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000032:analysis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry*; D031963:Sedum / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005419:Flavonoids