title: Control of grip and stick in cell adhesion through lateral relationships of membrane glycoproteins.
abstract: Although cell adhesion to substrate must ultimately depend on 'sticking' by physical forces at the outer surface, we suggest that control is exercised through the 'grip' of the cytoskeleton. Our experiments indicate that grip can be relaxed by agents which release surface glycoproteins from some form of side-to-side organisation, and can be consolidated by suitable cross-linking to augment this organisation.
authors.affiliation: Biosciences Division, Unilever Research/Welwyn Laboratory, Sharnbrook, UK.
authors.forename: D A
authors.initials: DA
authors.lastname: Rees
authors.forename: C W
authors.initials: CW
authors.lastname: Lloyd
authors.forename: D
authors.initials: D
authors.lastname: Thom
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D003599:Cytoskeleton / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008954:Models, Biological; D037121:Plant Lectins / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins; D037121:Plant Lectins