title: Noncatalytic mono-N-methylation of aniline in supercritical methanol: the kinetics and acid/base effect.
abstract: Aniline is easily N-methylated in supercritical methanol without catalyst at 350 degrees C and 0.237 g cm-3 to give mono-N-methylaniline with high selectivity, and the reaction rate is increased by a small amount of base (LiOH, NaOH, KOH, and CH3ONa), indicating a difference in the reaction mechanism from the ordinary acid-catalyzed one.
authors.affiliation: Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Higashi, Tsukuba, Ibaraki 305-8565, Japan. chikulin@ni.aist.go.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takebayashi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Morita
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Abe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Furuya
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sugeta
authors.forename: Katsuto
authors.initials: K
authors.lastname: Otake
mesh_terms: D000143:Acids / Q000737:chemistry*; D000468:Alkalies / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D007700:Kinetics; D000432:Methanol / Q000737:chemistry*; D008745:Methylation
chemical_list: D000143:Acids; D000468:Alkalies; D000814:Aniline Compounds; C023650:aniline; D000432:Methanol