A population-based case-control study of isolated ocular coloboma.
OBJECTIVE
To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma.


METHODS
The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit.


RESULTS
Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% CI: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases.


CONCLUSIONS
It is necessary to study the preventable environmental factors in the origin of these ocular defects.
Vogt
Gábor
G
Hospital and Central Outpatients Clinics of the Hungarian State Railways, Podmaniczky u. 111, H-1062 Budapest, Hungary. gabor.vogt@tosho.hu
Puhó
Erzsébet
E
Czeizel
Andrew E
AE
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D001724:Birth Weight; D016022:Case-Control Studies; D002829:Choroid / Q000002:abnormalities*; D003103:Coloboma / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D006896:Hydroxyethylrutoside / Q000009:adverse effects; D007223:Infant; D007231:Infant, Newborn; D007498:Iris / Q000002:abnormalities*; D008297:Male; D008423:Maternal Age; D009900:Optic Nerve / Q000002:abnormalities*; D012042:Registries
D006896:Hydroxyethylrutoside