ABCG1: how critical for cholesterol transport?
In the current issue of Cell Metabolism, Kennedy et al. (2005) have extended our understanding of the ABCG1 transporter. Their studies demonstrate that, at least in macrophages, ABCG1 is responsible for much of the cholesterol efflux that utilizes mature HDL as an acceptor.
Shachter
Neil S
NS
Columbia University, 630 W. 168th Street, PH 10-305, New York, New York 10032, USA.
D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism; D006579:Heterozygote; D006720:Homozygote; D008074:Lipoproteins / Q000378:metabolism / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism
C487540:ABCG1 protein, mouse; D000070998:ATP Binding Cassette Transporter, Subfamily G, Member 1; D018528:ATP-Binding Cassette Transporters; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D012333:RNA, Messenger; D002784:Cholesterol