Tumour size is an important predictor for the outcome after liver transplantation for hepatocellular carcinoma.
OBJECTIVE
Recently, there is a tendency to expand tumour sizes qualifying for OLT. The present study re-evaluates tumour size and histopathological features as selection criteria for OLT.


METHODS
Retrospective analysis of 93 adult HCC patients underwent OLT between June 1985 and December 2003. Median follow-up was 28 months (1-222 months). The Milan criteria were routinely applied since 1994.


RESULTS
Five year survival rate of HCC patients was significantly lower than in patients transplanted for benign diseases, 41 and 71%, respectively (p<0.0001). Multivariate analysis revealed that the presence of vascular invasion represents the most significant predictor (p<0.001) affecting the survival rate. Survival was also significantly impaired when the tumour size was >5 cm (p<0.05), whereas the number of nodules had no significant effect on survival. Consequently, the survival rate for HCC fulfilling the Milan criteria histologically improved to 70% since 1994.


CONCLUSIONS
Tumour size has been shown to be the most important pre-operatively detectable predictor for patient survival after OLT.
Löhe
F
F
Department of Surgery, Ludwig-Maximilians-University of Munich, Klinikum Grosshadern, Marchioninistr. 15, D-81377 Munich, Germany. floehe@med.uni-muenchen.de
Angele
M K
MK
Gerbes
A L
AL
Löhrs
U
U
Jauch
K-W
KW
Schauer
R J
RJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D015996:Survival Rate