title: Suicide prevention by lithium SUPLI--challenges of a multi-center prospective study.
abstract: Several studies have shown that there is a significantly increased risk of suicide related mortality in patients with a positive history of suicide attempts. The SUPLI-Study is the first prospective, randomized, double blind, placebo controlled multi-center trial focusing on the proposed suicide preventive effects of lithium in patients with suicidal behavior but not suffering from bipolar disorder or recurrent major depressive disorder. Patients with a recent history of a suicide attempt are treated with lithium versus placebo during a 12 month period. The hypothesis is that lithium treatment will lead to a 50% reduction of suicidal behavior. The protocol of the study and preliminary results are presented.
authors.affiliation: Department of Psychiatry and Psychotherapy, Universitätsklinikum Schleswig-Holstein, Luebeck, Germany. lauterbach.e@psychiatry.uni-luebeck.de
authors.forename: Erik
authors.initials: E
authors.lastname: Lauterbach
authors.forename: Bernd
authors.initials: B
authors.lastname: Ahrens
authors.forename: Werner
authors.initials: W
authors.lastname: Felber
authors.forename: Bruno Muller
authors.initials: BM
authors.lastname: Oerlinghausen
authors.forename: Birgit
authors.initials: B
authors.lastname: Kilb
authors.forename: Gerd
authors.initials: G
authors.lastname: Bischof
authors.forename: Isabella
authors.initials: I
authors.lastname: Heuser
authors.forename: Petra
authors.initials: P
authors.lastname: Werner
authors.forename: Barbara
authors.initials: B
authors.lastname: Hawellek
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Ute
authors.initials: U
authors.lastname: Lewitzka
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Thomas
authors.initials: T
authors.lastname: Bronisch
authors.forename: Kneginja
authors.initials: K
authors.lastname: Richter
authors.forename: Günther
authors.initials: G
authors.lastname: Niklewski
authors.forename: Andreas
authors.initials: A
authors.lastname: Broocks
authors.forename: Fritz
authors.initials: F
authors.lastname: Hohagen
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use*; D011446:Prospective Studies; D000092864:Suicide Prevention
chemical_list: D014150:Antipsychotic Agents; D016651:Lithium Carbonate