New class of bacterial membrane oxidoreductases.
A new class of bacterial multisubunit membrane-bound electron-transfer complexes has been identified based on biochemical and bioinformatic data. It contains subunits homologous to the three-subunit molybdopterin oxidoreductases and four additional subunits, two of which are c-type cytochromes. The complex was purified from the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus, and putative operons for similar complexes were identified in a wide range of bacteria. In most cases, the presence of the new complex is anticorrelated with the cytochrome bc or bf electron-transfer complex, suggesting that it replaces it functionally. This appears to be a widespread yet previously unrecognized protein complex involved in energy metabolism in bacteria.
Yanyushin
Mikhail F
MF
Institute of Basic Biological Problems, Russian Academy of Science, Pushchino, Moscow region, 142290 Russia.
del Rosario
Melissa C
MC
Brune
Daniel C
DC
Blankenship
Robert E
RE
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D041861:Chloroflexus / Q000201:enzymology* / Q000235:genetics; D019295:Computational Biology; D045304:Cytochromes c / Q000737:chemistry / Q000145:classification / Q000235:genetics; D004579:Electron Transport / Q000235:genetics; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D016680:Genome, Bacterial; D008565:Membrane Proteins / Q000737:chemistry* / Q000145:classification* / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D009876:Operon; D010802:Phylogeny; D021122:Protein Subunits / Q000737:chemistry / Q000145:classification / Q000235:genetics; D040681:Structural Homology, Protein
D001426:Bacterial Proteins; D008565:Membrane Proteins; D021122:Protein Subunits; D045304:Cytochromes c; D003576:Electron Transport Complex IV