Effect of reduced glutathione treatment on selenosis, blood selenium concentration and glutathione peroxidase activity after repeated short-term selenium exposure in buffalo calves.
Effects of repeated feeding of selenium, when given alone or along with reduced glutathione, on whole blood selenium levels, selenosis and glutathione peroxidase activity, was studied in buffalo calves. After feeding 2.5 mg/kg of BW sodium selenite, good correlation was found between the onset of selenosis and whole blood selenium concentrations. Adverse effects appeared when the whole blood selenium concentrations increased above 2 microg/ml and mortality occurred when they exceeded 3.4 microg/ml. Reduced glutathione, given i.v. at 5 mg/kg of BW arrested the progress of selenosis and prevented mortality which was 100% in the sodium selenite supplemented group; also a reduced whole blood selenium concentration was noted. Whole blood selenium concentrations were a better and more sensitive indicator of selenium status than glutathione peroxidase activity alone.
Deore
Milind Devidas
MD
Department of Pharmacology and Toxicology, College of Veterinary Sciences, Punjab Agricultural University, Ludhiana 141004, Punjab, India. mdeore@hotmail.com
Srivastava
Anil Kumar
AK
Sharma
Suresh Kumar
SK
D000818:Animals; D002020:Buffaloes / Q000097:blood*; D005978:Glutathione / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood*; D008297:Male; D012643:Selenium / Q000097:blood* / Q000633:toxicity
D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium