title: Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity.
abstract: Four new flavonoids, brosimacutins J-M (1 - 4), were isolated from the bark of Brosimum acutifolium Huber together with a known flavan, brosimine A (5). The structures of compounds 1-4 were elucidated by spectroscopic means. 27 constituents of this plant including compounds 1-5 were evaluated for their cytotoxic activity against murine leukemia P388 cells. Although no compounds tested had any reversal effect on vincristine resistance, brocimacutins J-M (1-4) were cytotoxic to vincristine-resistant P388 cells (IC50 4.4 - 19 microg/mL).
authors.affiliation: Research & Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Takashima.Junko@me.m-pharma.co.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Takashima
authors.forename: Kanki
authors.initials: K
authors.lastname: Komiyama
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ishiyama
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ohsaki
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001572:Benzofurans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D020128:Inhibitory Concentration 50; D007941:Leukemia P388 / Q000517:prevention & control; D051379:Mice; D029586:Moraceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D005419:Flavonoids; D010936:Plant Extracts