title: Effects of seprafilm on peritoneal fibrinolytic system.
abstract: BACKGROUND
  There is a high incidence of adhesions after ventral hernia repair with polypropylene mesh. The purpose of the present study was to evaluate the efficacy of Seprafilm in the prevention of adhesion formation and effect on peritoneal fibrinolytic activity.
  
  
  METHODS
  An incisional hernia model was created in rats. In the experimental group Seprafilm was placed between polypropylene mesh and abdominal organs. On the 14th day adhesions were evaluated and tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), plasminogen activator inhibitor (PAI) type 1 and 2 were measured in peritoneal biopsy specimens.
  
  
  RESULTS
  Adhesions were significantly reduced in the Seprafilm group (P = 0.002). Nevertheless, there were no difference between the two groups in levels of tPA, PAI-1 and PAI-2. However, the levels of uPA were significantly decreased in the Seprafilm group.
  
  
  CONCLUSIONS
  The adhesion preventive effect of Seprafilm is not directly related in peritoneal fibrinolytic activity. Instead, the physical properties (barrier, hydroflotation and sliconizing effect) of the membrane are primarily responsible for adhesion prevention.
authors.affiliation: Süleyman Demirel University Medical School, Isparta, Turkey. drtarhan@yahoo.com
authors.forename: Omer Ridvan
authors.initials: OR
authors.lastname: Tarhan
authors.forename: Aydan
authors.initials: A
authors.lastname: Eroglu
authors.forename: Recep
authors.initials: R
authors.lastname: Cetin
authors.forename: Ayper
authors.initials: A
authors.lastname: Y Nce
authors.forename: Mahmut
authors.initials: M
authors.lastname: Bulbul
authors.forename: Y Rfan
authors.initials: YR
authors.lastname: Altuntas
mesh_terms: D034861:Abdominal Wall / Q000601:surgery; D000818:Animals; D002266:Carboxymethylcellulose Sodium; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D008567:Membranes, Artificial; D010532:Peritoneal Diseases / Q000517:prevention & control*; D010537:Peritoneum / Q000378:metabolism*; D015849:Plasminogen Inactivators / Q000378:metabolism; D011126:Polypropylenes; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D008567:Membranes, Artificial; D015849:Plasminogen Inactivators; D011126:Polypropylenes; C118198:Seprafilm; D006820:Hyaluronic Acid; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; D002266:Carboxymethylcellulose Sodium