Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma.
We report a patient with adult T-cell lymphoma who developed acute myeloid leukemia (AML) after allogeneic cord blood transplantation (CBT). Fluorescence in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the AML to be of donor origin. Although 25 cases of donor cell leukemia (DCL) occurring after allogeneic bone marrow transplantation have previously been reported, there have been no reports of DCL after CBT. This case is the first-reported DCL patient after CBT.
Matsunaga
Takuya
T
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan. matunaga@sapmed.ac.jp
Murase
Kazuyuki
K
Yoshida
Makoto
M
Fujimi
Akihito
A
Iyama
Satoshi
S
Kuribayashi
Kageaki
K
Sato
Tsutomu
T
Kogawa
Katsuhisa
K
Hirayama
Yasuo
Y
Sakamaki
Sumio
S
Kohda
Kyuhei
K
Niitsu
Yoshiro
Y
D000208:Acute Disease; D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D036101:Cord Blood Stem Cell Transplantation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000235:genetics; D016399:Lymphoma, T-Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000235:genetics; D020080:Tandem Repeat Sequences; D014019:Tissue Donors; D018183:Transplantation Chimera; D014184:Transplantation, Homologous