The smoking-thrombolysis paradox and acute ischemic stroke.
Smokers with acute myocardial infarction have better outcomes after thrombolysis than nonsmokers. The authors evaluated the independent effect of smoking on short-term outcome following IV thrombolysis for acute ischemic stroke. After adjusting for covariates, recent smokers who received thrombolysis had a significantly greater drop in 24-hour median stroke severity scores from baseline than nonsmokers who received thrombolysis and lower mortality over 1 year.
Ovbiagele
Bruce
B
Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA. Ovibes@mednet.ucla.edu
Saver
Jeffrey L
JL
D000367:Age Factors; D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D001786:Blood Glucose / Q000502:physiology; D002545:Brain Ischemia / Q000188:drug therapy / Q000401:mortality* / Q000503:physiopathology; D015984:Causality; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000401:mortality* / Q000503:physiopathology; D015897:Comorbidity; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology*; D020521:Stroke / Q000188:drug therapy / Q000401:mortality* / Q000503:physiopathology; D015996:Survival Rate; D014026:Nicotiana / Q000378:metabolism; D016896:Treatment Outcome
D001786:Blood Glucose; D005343:Fibrinolytic Agents