Latifolians A and B, novel JNK3 kinase inhibitors from the Papua New Guinean plant Gnetum latifolium.
As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR analysis. The relative configurations were assigned after examination of the ROESY data and through detailed molecular modeling studies.
Rochfort
Simone J
SJ
Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
Towerzey
Leanne
L
Carroll
Anthony
A
King
Gordon
G
Michael
Adam
A
Pierens
Greg
G
Rali
Topul
T
Redburn
Joanne
J
Whitmore
Jaqueline
J
Quinn
Ronald J
RJ
D044182:Benzylisoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035684:Gnetum / Q000737:chemistry*; D048057:Mitogen-Activated Protein Kinase 10 / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D044182:Benzylisoquinolines; D004791:Enzyme Inhibitors; C503006:latifolian A; C503007:latifolian B; D048057:Mitogen-Activated Protein Kinase 10