Transcriptional regulation and transformation by Myc proteins.
Myc genes are key regulators of cell proliferation, and their deregulation contributes to the genesis of most human tumours. Recently, a wealth of data has shed new light on the biochemical functions of Myc proteins and on the mechanisms through which they function in cellular transformation.
Adhikary
Sovana
S
Institute for Molecular Biology and Tumour Research, University of Marburg, Emil-Mannkopff-Strasse 2, 35033 Marburg, Germany.
Eilers
Martin
M
D001665:Binding Sites; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins