Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure.
BACKGROUND
It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein over an extended period and may thus mirror oxidative stress over a prolonged time frame. Therefore, we tested the hypothesis that anti-oxLDL antibodies correlate with the control of heart failure (HF), as manifested by hospital admissions for cardiac dysfunction.


METHODS
One hundred and two consecutive patients attending the HF clinic with either systolic or diastolic HF were enrolled and the quality of clinical control was evaluated by assessing hospital admissions over the year prior to index determination of the oxidative stress marker. Antibodies to oxLDL were determined by ELISA and pro-BNP levels were also measured.


RESULTS
Most patients (mean age 71.5 years) had systolic HF; mean NYHA functional class was 2.7 and mean left ventricular ejection fraction was 39.7%. Anti-oxLDL antibodies, but not pro-BNP, correlated significantly with mean NYHA score (averaged from all clinic visits in the year prior to blood testing), and with hospital admissions over the year prior to blood testing. Mean IgG anti-oxLDL antibody levels in patients with hospital admissions were 3.4 times higher than those in subjects not hospitalized over the previous year.


CONCLUSIONS
IgG anti-oxLDL antibody levels correlate with the severity of HF.
George
Jacob
J
The Department of Cardiology, Tel Aviv Sourasky Medical Center, Israel; The Sackler Faculty of Medicine, Tel Aviv University, Israel. jacobg@post.tau.ac.il
Wexler
Dov
D
Roth
Arie
A
Barak
Tomer
T
Sheps
David
D
Keren
Gad
G
D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood; D012189:Retrospective Studies; D012720:Severity of Illness Index
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; D010446:Peptide Fragments; D011498:Protein Precursors; C099252:oxidized low density lipoprotein; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain