Antiglial cell autoantibodies and childhood epilepsy: a case report.
We report the case of a patient with severe partial epilepsy associated with a focal rolandic, pathologically proven, cortical dysplasia. By measuring intracellular calcium concentrations, functional antiglial non-glutamate receptor 3 (GluR3) autoantibodies were identified in the serum of this patient. Antineuronal autoantibodies, which interfere with GluR3-receptor function, also were detected. This observation provides new clues about the involvement of immunologic mechanisms in epileptic disorders.
Roubertie
Agathe
A
Inserm U-583, Hôpital Saint Eloi, Montpellier, France.
Boukhaddaoui
Hassan
H
Sieso
Victor
V
de Saint-Martin
Anne
A
Lellouch-Tubiana
Arielle
A
Hirsch
Edouard
E
Echenne
Bernard
B
Valmier
Jean
J
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D002118:Calcium / Q000032:analysis; D002478:Cells, Cultured / Q000187:drug effects; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000209:etiology / Q000276:immunology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007608:Kainic Acid / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D008297:Male; D009457:Neuroglia / Q000737:chemistry / Q000276:immunology*; D009474:Neurons / Q000737:chemistry / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000276:immunology
D001323:Autoantibodies; D005904:Glial Fibrillary Acidic Protein; D018091:Receptors, AMPA; C104723:glutamate receptor ionotropic, AMPA 3; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D007608:Kainic Acid; D002118:Calcium