Cardiac resynchronization therapy--how big of a miracle?
This review examines the clinical benefit of cardiac resynchronization therapy (CRT) in patients with severe heart failure symptoms and interventricular conduction delay. The magnitude of CRT effects on exercise duration, quality of life, and reversal of adverse remodeling are compared to angiotensin-converting enzyme (ACE) inhibitor therapy and combined beta-blocker/ACE inhibitor therapy. Overall, CRT delivers substantial improvement in clinical well-being to an extent similar to or greater than what would be expected with neurohormonal intervention alone.
Adamson
Philip B
PB
University of Oklahoma Health Sciences Center, 920 SL Young Boulevard, WP3120, Oklahoma City, OK 73190, USA. philip-adamson@ouhsc.edu
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D017079:Exercise Tolerance; D006329:Heart Conduction System / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D018579:Patient Selection; D011788:Quality of Life; D020257:Ventricular Remodeling / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors