title: The impact of size of the adnexal mass on the accuracy of frozen section diagnosis.
abstract: OBJECTIVE
  We recently showed that frozen section diagnosis has an almost perfect specificity for the diagnosis of malignancy in an adnexal mass, whereas the sensitivity was, though good, not perfect. The aim of the present study was to examine whether the accuracy of frozen section diagnosis is affected by the size of the adnexal masses.
  
  
  METHODS
  We included women that underwent frozen section diagnosis for adnexal mass surgery. For each patient we recorded serum CA125 level, menopausal status, tumour size, and histologic classification both at frozen section diagnosis and at definite histological examination. We calculated sensitivity and specificity of frozen section diagnoses, both in tumours below and above 10 cm diameter.
  
  
  RESULTS
  We included 257 patients, of whom 142 had a benign tumour, 28 had a borderline tumour and 87 had a malignant tumour at definitive histological assessment. In case frozen section diagnosis showed malignancy, this was always confirmed at final histological assessment. In women with a tumour <10 cm, there was only 1 false negative diagnosis in 50 women with a benign frozen section diagnosis, whereas there were 11 false negative diagnoses in 97 women in women with a tumour > or = 10 cm. The corresponding likelihood ratios of a benign diagnosis for presence of malignancy were .15 for tumours > or = 10 cm and 0.03 for tumours <10 cm, respectively.
  
  
  CONCLUSIONS
  The accuracy of frozen section diagnosis is dependent on tumour size. In adnexal masses > or = 10 cm, a benign result of the frozen section diagnosis is less reliable than in women with a tumour <10 in cm.
authors.affiliation: Department of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven, The Netherlands. peggy.geomini@12move.nl
authors.forename: Peggy M A J
authors.initials: PM
authors.lastname: Geomini
authors.forename: Laura D
authors.initials: LD
authors.lastname: Zuurendonk
authors.forename: Gérard L
authors.initials: GL
authors.lastname: Bremer
authors.forename: Jan
authors.initials: J
authors.lastname: de Graaff
authors.forename: Roy F P M
authors.initials: RF
authors.lastname: Kruitwagen
authors.forename: Ben W J
authors.initials: BW
authors.lastname: Mol
mesh_terms: D000290:Adnexa Uteri / Q000378:metabolism / Q000473:pathology*; D000291:Adnexal Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000378:metabolism; D005260:Female; D005629:Frozen Sections; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D018394:CA-125 Antigen