Transforming growth factor beta and connective tissue growth factor are involved in the evolution of nevus of Nanta.
We report a 59-year-old Japanese male with nevus of Nanta on the face. Histological examination revealed a nest of nevus cells in the dermis and ossification beneath the nevus. Positive staining for transforming growth factor-beta and connective tissue growth factor suggested the involvement of these growth factors in the ossification of nevus of Nanta.
Keida
Tomoko
T
Department of Dermatology, Seibo Hospital, Tokyo, Japan.
Hayashi
Nobukazu
N
Kawakami
Michiko
M
Kawashima
Makoto
M
D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D055513:Connective Tissue Growth Factor; D005500:Follow-Up Studies; D006801:Humans; D017874:Immediate-Early Proteins / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000378:metabolism*; D008233:Lymphotoxin-alpha / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000473:pathology* / Q000601:surgery; D009999:Ossification, Heterotopic / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
D015415:Biomarkers; C526317:CCN2 protein, human; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008233:Lymphotoxin-alpha; D055513:Connective Tissue Growth Factor