title: Lack of alkaline phosphatase activity predicts meningioma recurrence.
abstract: Meningiomas usually are benign intracranial tumors. However, some recur despite gross total resection, invade surrounding structures, or, rarely, metastasize. Reduced expression of the nonspecific tissue-type alkaline phosphatase (Pal) has been reported in high-grade meningiomas. To search for a predictor for recurrence, we studied Pal expression by histoenzymology in a series of 54 meningiomas with gross total removal. Pal expression was mostly altered in grades II and III meningiomas (P = .000014) and meningiomas with high MIB-1 values (P = .001). Pal expression correlated with cytogenetic data (P = .000033) and with recurrence (P = .0064); all tumors that recurred had abnormal Pal expression (13/13). In univariate analysis, Pal expression was the only variable correlated with recurrence-free survival (P = .035). Histochemical detection of Pal is a useful, easy, and low-cost technique to predict recurrence in meningiomas.
authors.affiliation: Department of Pathology, Faculty of Medicine, Timone Hospital, Marseille, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Bouvier
authors.forename: Agnès
authors.initials: A
authors.lastname: Liprandi
authors.forename: Carole
authors.initials: C
authors.lastname: Colin
authors.forename: Roch
authors.initials: R
authors.lastname: Giorgi
authors.forename: Benoit
authors.initials: B
authors.lastname: Quilichini
authors.forename: Philippe
authors.initials: P
authors.lastname: Metellus
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008579:Meningioma / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D000469:Alkaline Phosphatase