Pharmacokinetics of therapeutic monoclonal antibodies used in oncology.
This review presents the clinical pharmacokinetics of the marketed therapeutic monoclonal antibodies used in oncology. Aspects regarding absorption, tissue distribution, elimination as well as factors influencing pharmacokinetics, pharmacodynamics and kinetic interactions are also discussed.
Levêque
Dominique
D
Hôspital de Hautepierre, pharmacie, Avenue Molière, 67000 Strasbourg. dominique.leveque@chru-strasbourg.fr
Wisniewski
Sandra
S
Jehl
François
F
D000911:Antibodies, Monoclonal / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D018796:Immunoconjugates / Q000493:pharmacokinetics; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy
D000911:Antibodies, Monoclonal; D018796:Immunoconjugates