title: Morpho-functional features in adolescent males under iodine deficiency of the Saratov region.
abstract: An auxological study of 538 adolescent males (from 12 to 17) from different settlements of the Saratov region with various degrees of industrialization and iodine deficiency was carried out. All subjects have undergone an ultra-sound screening of thyroid volume to reveal the frequency of endemic goiter in each group. The results obtained during investigation showed the existence of deviations in the physical development of boys with goiter in skinfold thickness, body circumferences (chest, shoulder, and forearm), biacromial and biiliocristal diameters, transversal and sagittal chest diameters, body height and weight, BMI, leg length, and corpus length, all of which are greater in healthy adolescents (SD = 1.0, p = 0.000). In 46 subjects with endemic goiter, characteristics of metabolic status were investigated by the method of registration of endogenous intoxication (Malakhova, 1995). In comparison to the control group, a 1.2 times lower LAMM level in erythrocytes (p < 0.05) and 1.1 in urine (p < 0.05), and an increase by 2.3 in the LAMM level in blood plasma (p < 0.01) were detected. The relative percentage of catabolic substances exceeded the control values by 3.2 (p < 0.001). The OP level in erythrocytes is reduced by 2.2 (p < 0.01), in urine (p < 0.01) by 8.4. The OP level is higher in plasma by 3.0 (p < 0.01). The adolescents with endemic goiter have a reallocation of protein matter between erythrocytes, plasma and urine. The spectrogram of erythrocytes shows lowering metabolites on membrane frames, which testifies to the destruction of the structurally functional properties of erythrocytes, and a lowering of absorption properties in glycocalix erythrocytes.
authors.affiliation: Biological Faculty of Saratov State University, Moscow, Russia. popovskyL@mail.ru
authors.forename: Aleksey
authors.initials: A
authors.lastname: Popovsky
authors.forename: Roman
authors.initials: R
authors.lastname: Kireev
authors.forename: Irena
authors.initials: I
authors.lastname: Khomyakova
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001774:Blood Chemical Analysis; D001837:Body Weights and Measures / Q000706:statistics & numerical data; D004912:Erythrocytes / Q000378:metabolism; D006043:Goiter, Endemic / Q000453:epidemiology*; D006801:Humans; D007455:Iodine / Q000172:deficiency*; D008297:Male; D009842:Oligopeptides / Q000378:metabolism; D012426:Russia / Q000453:epidemiology; D012741:Sexual Maturation / Q000502:physiology; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D009842:Oligopeptides; D007455:Iodine