Energizer: PGC-1 alpha keeps the heart going.
In the current issue of Cell Metabolism, Arany et al. (2005) demonstrate essential roles for PGC-1alpha in cardiac metabolism, proving several long-postulated functions while disproving others. These experiments conclusively reinforce the logic of rescuing PGC-1alpha as a novel therapeutic target in heart failure.
Sano
Motoaki
M
Department of Medicine, Center for Cardiovascular Development, Baylor College of Medicine, Houston, Texas 77030, USA.
Schneider
Michael D
MD
D000818:Animals; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors
D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors