Effects of aminopentol on in utero development in rats.
Aminopentol (AP1), the backbone and main hydrolysis product of the mycotoxin fumonisin B1 (FB1), is present in corn-based foods which are consumed daily as a substantial part of the diet in some areas of the world. The toxicity of FB1 has been attributed to altered sphingolipid metabolism, but the toxicity of AP1 is less certain. Epidemiological correlations and in vitro studies have suggested that AP1 can increase neural tube defects (NTDs), but no in vivo developmental study of AP1 was done prior to this study. AP1 was given once daily to rats by gavage on gestation days (GD) 3-16 at doses of 0, 15, 30, 60, or 120 mg/kg. Reproductive and developmental parameters were measured at GD 17, one day after the last dose, and on GD 20. In addition, on GD 17, maternal and fetal tissues were analyzed for sphingolipid content.


CONCLUSIONS
AP1 reduced dam body weight gain, but was less toxic than FB1. AP1 was not teratogenic, did not affect tissue sphingolipid ratios, did not alter reproduction or development of fetuses, and produced no dose-related histopathological effects in dams.
Collins
Thomas F X
TF
Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. tcollins@cfsan.fda.gov
Sprando
Robert L
RL
Black
Thomas N
TN
Olejnik
Nicholas
N
Eppley
Robert M
RM
Shackelford
Mary E
ME
Howard
Paul C
PC
Rorie
James I
JI
Bryant
Mark
M
Ruggles
Dennis I
DI
D000383:Agriculture; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002264:Carboxylic Acids / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005333:Fetus / Q000473:pathology; D008297:Male; D009436:Neural Tube Defects / Q000139:chemically induced / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013107:Sphingolipids / Q000378:metabolism; D014599:Uterus / Q000187:drug effects; D003313:Zea mays
D002264:Carboxylic Acids; D013107:Sphingolipids; C110744:aminopentol