On the existence of cellular tocopheryl phosphate, its synthesis, degradation and cellular roles: a hypothesis.
The finding that alpha-tocopheryl phosphate is present in cells in small amounts, that it can be synthesized and hydrolyzed supports the hypothesis that alpha-tocopheryl phosphate might be a signaling molecule. The possible pathways needed for the synthesis, hydrolysis and signaling are considered in this hypothesis as well the possible extension of this reaction to additional molecules such as tocopherols and tocotrienols. A possible mechanism of action of other tocopherol esters (succinate and maleate) is also hypothesized.
Negis
Yesim
Y
Department of Biochemistry, Marmara University, Istanbul, Turkey.
Zingg
Jean-Marc
JM
Ogru
Esra
E
Gianello
Robert
R
Libinaki
Roksan
R
Azzi
Angelo
A
D002468:Cell Physiological Phenomena; D006801:Humans; D006868:Hydrolysis; D008954:Models, Biological; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000378:metabolism
C012552:alpha-tocopherol phosphate; D024502:alpha-Tocopherol