title: Condensation reaction between angiotensin II and dicarboxylic acid in water at high temperature without any catalytic agent additive.
abstract: The condensation reaction of angiotensin II and tartaric acid in water at 100-140 degrees C proceeded without any added catalytic agent. One of the products, N-CO-tartarylangiotensin II, was confirmed by LC-MS, positive-ion MALDI-MS, and the fluorescamine method as a condensation product. The initial concentration of the substrates, temperatures, and initial pH affected the yield of the product. The higher concentrations and temperatures increased the concentration of the condensation product. The optimal pH for the condensation reaction was 3.0. The other C4 saturated dicarboxylic acids, malic and succinic acids, were also condensed by angiotensin II.
authors.affiliation: Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Asano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maeda
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Taro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Maeda
authors.forename: Shuji
authors.initials: S
authors.lastname: Adachi
mesh_terms: D000804:Angiotensin II / Q000737:chemistry*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003998:Dicarboxylic Acids / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008293:Malates / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013386:Succinates / Q000737:chemistry; D013644:Tartrates / Q000737:chemistry; D013696:Temperature; D014867:Water
chemical_list: D003998:Dicarboxylic Acids; D008293:Malates; D013386:Succinates; D013644:Tartrates; D014867:Water; D000804:Angiotensin II; C030298:malic acid; C029768:tartaric acid