title: Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation.
abstract: The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.
authors.affiliation: Department of Medicine B2142, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lasse S
authors.initials: LS
authors.lastname: Ravn
authors.forename: Jacob
authors.initials: J
authors.lastname: Hofman-Bang
authors.forename: Ulrik
authors.initials: U
authors.lastname: Dixen
authors.forename: Severin Olesen
authors.initials: SO
authors.lastname: Larsen
authors.forename: Gorm
authors.initials: G
authors.lastname: Jensen
authors.forename: Stig
authors.initials: S
authors.lastname: Haunsø
authors.forename: Jesper Hastrup
authors.initials: JH
authors.lastname: Svendsen
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*; D018570:Risk Assessment
chemical_list: C489619:KCNE2 protein, human; D024642:Potassium Channels, Voltage-Gated