title: Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia.
abstract: It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors. Logistic regression analysis showed that neither tHcy nor MTHFR polymorphisms were associated with schizophrenia. Homozygosity for MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (P<0.01), which was mainly driven by the male group. The A1298C variant did not show any association with tHcy concentrations. In conclusion, these results do not confirm an independent relationship of tHcy and MTHFR genotype with risk of schizophrenia.
authors.affiliation: Psychiatric University Hospital Institut Pere Mata, Unitat de Psiquiatria, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain. elisabet.vilella@urv.net
authors.forename: Elisabet
authors.initials: E
authors.lastname: Vilella
authors.forename: Carmen
authors.initials: C
authors.lastname: Virgos
authors.forename: Michelle
authors.initials: M
authors.lastname: Murphy
authors.forename: Lourdes
authors.initials: L
authors.lastname: Martorell
authors.forename: Joaquín
authors.initials: J
authors.lastname: Valero
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Simó
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
authors.forename: Joan
authors.initials: J
authors.lastname: Fernández-Ballart
authors.forename: Antonio
authors.initials: A
authors.lastname: Labad
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012737:Sex Factors
chemical_list: D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)