title: Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc.
abstract: Novel bifunctional chelating agents bearing an aromatic rigid backbone have been synthesized and characterized on the basis of spectroscopic techniques. These macrocyclic multidentate chelating agents were conjugated with monoclonal antibody which forms stable complexes with 99mTc with high radiochemical purity.
authors.affiliation: Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
authors.forename: Bhupender S
authors.initials: BS
authors.lastname: Chhikara
authors.forename: Nitin
authors.initials: N
authors.lastname: Kumar
authors.forename: Vibha
authors.initials: V
authors.lastname: Tandon
authors.forename: Anil K
authors.initials: AK
authors.lastname: Mishra
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007553:Isotope Labeling; D015394:Molecular Structure; D013440:Sulfides / Q000737:chemistry*; D013667:Technetium / Q000032:analysis*
chemical_list: D000473:Alkanes; D002614:Chelating Agents; D013440:Sulfides; D013667:Technetium