title: Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis.
abstract: Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.
authors.affiliation: Departamento de Biologia Celular, Laboratório de Biologia Molecular, Instituto de Biologia, Universidade de Brasília. msueli@unb.br
authors.forename: Maria Sueli S
authors.initials: MS
authors.lastname: Felipe
authors.forename: Fernando A G
authors.initials: FA
authors.lastname: Torres
authors.forename: Andrea Q
authors.initials: AQ
authors.lastname: Maranhão
authors.forename: Ildinete
authors.initials: I
authors.lastname: Silva-Pereira
authors.forename: Marcio J
authors.initials: MJ
authors.lastname: Poças-Fonseca
authors.forename: Elida G
authors.initials: EG
authors.lastname: Campos
authors.forename: Lídia M P
authors.initials: LM
authors.lastname: Moraes
authors.forename: Fabrício B M
authors.initials: FB
authors.lastname: Arraes
authors.forename: Maria José A
authors.initials: MJ
authors.lastname: Carvalho
authors.forename: Rosângela V
authors.initials: RV
authors.lastname: Andrade
authors.forename: André M
authors.initials: AM
authors.lastname: Nicola
authors.forename: Marcus M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Rosália S A
authors.initials: RS
authors.lastname: Jesuíno
authors.forename: Maristela
authors.initials: M
authors.lastname: Pereira
authors.forename: Célia M A
authors.initials: CM
authors.lastname: Soares
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Brígido
mesh_terms: D020224:Expressed Sequence Tags; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal; D006801:Humans; D010228:Paracoccidioides / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity; D010229:Paracoccidioidomycosis / Q000382:microbiology*; D014158:Transcription, Genetic
chemical_list: D005656:Fungal Proteins