A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results.
The subproject 1.5 "Neurobiology of Suicidal Behavior" is a multicenter study assessing peripheral parameters of the serotonergic, noradrenergic, and dopaminergic transmitter systems. Additionally, stress hormones and the lipid system as well as inhibitory and excitatory amino acids will be investigated. The different parameters are collected in cerebral spinal fluid (CSF), blood, and saliva. Patients with a depressive spectrum disorder with and without a suicide attempt (during the last three weeks) and being medication free for two weeks are included in the study. So far, 103 patients and controls have been recruited. The design and development of this project as well as interconnections with the others subprojects are described. Preliminary results about the stress hormone system and suicidality are presented.
Bronisch
Thomas
T
Max-Planck Institute of Psychiatry, Munich, Germany. bronisch@mpipsykl.mpg.de
Brunner
Jürgen
J
Bondy
Brigitta
B
Rujescu
Dan
D
Bishof
Gerd
G
Heuser
Isabella
I
Müller-Oerlinghausen
Bruno
B
Hawellek
Barbara
B
Maier
Wolfgang
W
Rao
Marie Luise
ML
Felber
Werner
W
Lewitzka
Ute
U
Oehler
Jochen
J
Broocks
Andreas
A
Hohagen
Fritz
F
Lauterbach
Erik
E
D000374:Aggression / Q000523:psychology; D001007:Anxiety / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007175:Impulsive Behavior / Q000523:psychology; D050356:Lipid Metabolism; D008995:Monoamine Oxidase / Q000097:blood; D009638:Norepinephrine / Q000378:metabolism; D011446:Prospective Studies; D012701:Serotonin / Q000378:metabolism*; D013406:Suicide, Attempted / Q000208:ethnology* / Q000523:psychology*
D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine