[Functional significance of L-type high voltage-gated calcium channels after sustained ethanol exposure].
Functional significance of enhancement of L-type high voltage-gated calcium channels (HVCCs) induced by sustained ethanol exposure in mouse cerebral cortical neurons were focused in this review. Sustained ethanol exposure to the neurons induced up-regulation of L-type HVCCs, which was due to increased expression of a 1 and a 2/ delta 1 subunits. In the cerebral cortex prepared from alcohol-dependent mice, similar pattern of alterations in the expressed subunits examined were also found. These data indicate that the increased expression of alpha 1 and alpha 2/ delta 1 subunits of L-type HVCCs is an essential biochemical event in cerebral cortex of alcohol-dependent mouse.
Katsura
Masashi
M
Department of Pharmacology, Kawasaki Medical University, 577, Matsushima, Kurashiki 701-0192, Japan.
Ohkuma
Seitaro
S
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism
D015220:Calcium Channels