title: Paratesticular cysts with benign epithelial proliferations of wolffian origin.
abstract: Paratesticular cysts with benign epithelial proliferations (BEPs) are rare. Only 10 cases were found in a series of 431 paratesticular cysts and were classified as follows: cystadenoma, 5; papilloma, 2; and hamartoma, 3. Four cystadenomas showed multiple papillae lined by CD10+ epithelial cells with hyperchromatic nuclei. The remaining lesion showed areas with a microcystic, glandular, cribriform pattern, with small, benign glands without atypia. Urothelial papilloma presented BEPs with cytokeratin (CK) 7+ and CD10+ and CK20- umbrella-like cells. The mural papilloma was lined by proliferative cylindrical cells exhibiting strong CK7 and CD10 expression. The 3 Wolffian hamartomas were characterized by strongly CD10+ epithelium surrounded by smooth muscle cells. The consistent CD10 expression in BEPs of paratesticular cysts suggests a Wolffian origin. The differential diagnosis of paratesticular cysts with BEP vs metastatic prostatic and primary borderline or malignant tumors is discussed.
authors.affiliation: Department of Pathology, La Paz University Hospital, Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Nistal
authors.forename: Pilar
authors.initials: P
authors.lastname: González-Peramato
authors.forename: Alvaro
authors.initials: A
authors.lastname: Serrano
authors.forename: Maria
authors.initials: M
authors.lastname: Vega-Perez
authors.forename: Maria P
authors.initials: MP
authors.lastname: De Miguel
authors.forename: Javier
authors.initials: J
authors.lastname: Regadera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018292:Cystadenoma, Papillary / Q000378:metabolism / Q000473:pathology; D003560:Cysts / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology*; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000378:metabolism; D008297:Male; D008650:Mesonephros / Q000473:pathology*; D008875:Middle Aged; D015260:Neprilysin / Q000378:metabolism; D010212:Papilloma / Q000378:metabolism / Q000473:pathology; D013733:Testicular Diseases / Q000378:metabolism / Q000473:pathology*
chemical_list: D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins; D015260:Neprilysin