Genetic mutual relationship between PTEN and p53 in gastric cancer.
Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric cancer patients. We observed the LOH of PTEN in 11.1% of the patients with normal p53s and 46.2% of the patients with p53 gene mutations. The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development.
Oki
Eiji
E
Department of Surgery and Science, Graduate School of Kyushu University 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. okieiji@surg2.med.kyushu-u.ac.jp
Tokunaga
Eriko
E
Nakamura
Toshihiko
T
Ueda
Naoyuki
N
Futatsugi
Motonori
M
Mashino
Kohjiro
K
Yamamoto
Manabu
M
Watanabe
Masayuki
M
Ikebe
Masahiko
M
Kakeji
Yoshihiro
Y
Baba
Hideo
H
Maehara
Yoshihiko
Y
D000368:Aged; D005260:Female; D016158:Genes, p53; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D009154:Mutation; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human