Clinical features of status epilepticus in patients with HIV infection.
The authors reviewed the records of 42 patients with HIV infection and status epilepticus (SE). Brain tumor and infection were the most common etiologies. The median duration of SE was 2.0 +/- 10 hours. Most patients (37 [88%]) responded to IV benzodiazepine or phenytoin treatment. Nevertheless, 12 (29%) patients died and 15 (36%) developed new neurologic deficits. In patients with HIV infection, aggressive management of seizures may limit the risk of SE.
Lee
Kelly C
KC
School of Pharmacy, Loma Linda University, 11262 Campus Street, West Hall 1333, Loma Linda, CA 92350, USA. kclee@rx.llu.edu
Garcia
Paul A
PA
Alldredge
Brian K
BK
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage; D001569:Benzodiazepines / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000150:complications* / Q000276:immunology*; D002494:Central Nervous System Infections / Q000150:complications* / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007275:Injections, Intravenous; D008223:Lymphoma / Q000150:complications / Q000276:immunology; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000276:immunology; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage; D012189:Retrospective Studies; D012307:Risk Factors; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D013226:Status Epilepticus / Q000188:drug therapy / Q000209:etiology*; D015996:Survival Rate; D016781:Toxoplasmosis, Cerebral / Q000150:complications / Q000276:immunology
D044966:Anti-Retroviral Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D010672:Phenytoin