title: A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.
abstract: Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Brown
authors.forename: E
authors.initials: E
authors.lastname: Peet
authors.forename: S B
authors.initials: SB
authors.lastname: Manuck
authors.forename: D E
authors.initials: DE
authors.lastname: Williamson
authors.forename: R E
authors.initials: RE
authors.lastname: Dahl
authors.forename: R E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: A R
authors.initials: AR
authors.lastname: Hariri
mesh_terms: D000679:Amygdala / Q000201:enzymology* / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood; D017384:Sequence Deletion; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase; D010100:Oxygen