Kinetic resolution of alcohols using a 1,2-dihydroimidazo[1,2-a]quinoline enantioselective acylation catalyst.
A new enantioselective acylation catalyst (Cl-PIQ), designed to provide enhanced pi-stacking with benzylic and cinnamyl alcohol substrates, was found to give considerably increased reaction rates and selectivities compared with the first-generation catalyst CF(3)-PIP. [reaction: see text]
Birman
Vladimir B
VB
Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, MO 63130, USA. birman@wustl.edu
Jiang
Hui
H
D000215:Acylation; D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007700:Kinetics; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*
C510438:1,2-dihydroimidazo(1,2-a)quinoline; C510439:2-phenyl-6-trifluoromethyl-dihydroimidazo(1,2-a)pyridine; D000438:Alcohols; D011725:Pyridines; D011804:Quinolines