title: Latifolians A and B, novel JNK3 kinase inhibitors from the Papua New Guinean plant Gnetum latifolium.
abstract: As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR analysis. The relative configurations were assigned after examination of the ROESY data and through detailed molecular modeling studies.
authors.affiliation: Natural Product Discovery, Eskitis Institute, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Simone J
authors.initials: SJ
authors.lastname: Rochfort
authors.forename: Leanne
authors.initials: L
authors.lastname: Towerzey
authors.forename: Anthony
authors.initials: A
authors.lastname: Carroll
authors.forename: Gordon
authors.initials: G
authors.lastname: King
authors.forename: Adam
authors.initials: A
authors.lastname: Michael
authors.forename: Greg
authors.initials: G
authors.lastname: Pierens
authors.forename: Topul
authors.initials: T
authors.lastname: Rali
authors.forename: Joanne
authors.initials: J
authors.lastname: Redburn
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Whitmore
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
mesh_terms: D044182:Benzylisoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035684:Gnetum / Q000737:chemistry*; D048057:Mitogen-Activated Protein Kinase 10 / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D044182:Benzylisoquinolines; D004791:Enzyme Inhibitors; C503006:latifolian A; C503007:latifolian B; D048057:Mitogen-Activated Protein Kinase 10