title: Tumour biology: senescence in premalignant tumours.
abstract: Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.
authors.affiliation: Spanish National Cancer Centre (CNIO), Madrid 28029, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Collado
authors.forename: Jesús
authors.initials: J
authors.lastname: Gil
authors.forename: Alejo
authors.initials: A
authors.lastname: Efeyan
authors.forename: Carmen
authors.initials: C
authors.lastname: Guerra
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Schuhmacher
authors.forename: Marta
authors.initials: M
authors.lastname: Barradas
authors.forename: Alberto
authors.initials: A
authors.lastname: Benguría
authors.forename: Angel
authors.initials: A
authors.lastname: Zaballos
authors.forename: Juana M
authors.initials: JM
authors.lastname: Flores
authors.forename: Mariano
authors.initials: M
authors.lastname: Barbacid
authors.forename: David
authors.initials: D
authors.lastname: Beach
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000483:Alleles; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016922:Cellular Senescence; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D011905:Genes, ras / Q000235:genetics; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D020411:Oligonucleotide Array Sequence Analysis; D011230:Precancerous Conditions / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D001616:beta-Galactosidase / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D006570:Heterochromatin; D001616:beta-Galactosidase