[Myocardial preconditioning with volatile anesthetics. General anesthesia as protective intervention?].
Reduction of the perioperative cardiovascular risk with pharmacological interventions plays a prominent role in routine anesthesia practice. For example, perioperative beta-blockade is well established in anesthesiological treatment of patients. There is a growing body of evidence supporting the cardioprotective effects of volatile anesthetics known as anesthetic-induced preconditioning. There are numerous and complex data from animal studies. The mechanisms of anesthetic-induced preconditioning have been extensively studied but have still not been clearly identified. Initial clinical data show the cardioprotective effects of volatile agents by looking at parameters of myocardial function and laboratory values and therefore, the question of the relevance of these data for routine clinical practice has been raised. This review gives a summary of the currently available data focusing on the mechanisms of anesthesiological preconditioning and clinical studies.
Buchinger
H
H
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.
Grundmann
U
U
Ziegeler
S
S
D000758:Anesthesia; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D020011:Protective Agents; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D018685:Anesthetics, Inhalation; D020011:Protective Agents