title: Asymmetric synthesis of 3,3-diarylpropanals with chiral diene-rhodium catalysts.
abstract: A general route to enantioenriched 3,3-diarylpropanals is presented. These useful building blocks are prepared via an asymmetric rhodium-catalyzed conjugate addition of arylboronic acids to cinnamaldehyde derivatives in the presence of chiral dienes. The addition of both electron-poor as well as electron-rich boronic acids proceeds smoothly with various enals in 63-90% yield with high enantioselectivities (89-93% ee).
authors.affiliation: Laboratorium für Organische Chemie, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Paquin
authors.forename: Christian
authors.initials: C
authors.lastname: Defieber
authors.forename: Corey R J
authors.initials: CR
authors.lastname: Stephenson
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira