title: [Oxidative injury and serum cytokines in coal workers with pneumoconiosis].
abstract: OBJECTIVE
  To inquire into the implication of oxidative injury and two cytokines TGF-beta1 and FGF in the occurrence and development of coal worker's Pneumoconiosis.
  
  
  METHODS
  The methods of nitrate reductase, TBA, and xanthine oxidase were used to detect the levels of serum NO, MDA and SOD respectively in 50 patients suffering from coal worker's Pneumoconiosis and 50 healthy controls, then ELISA was performed to detect the level of TGF-beta1 and FGF in the two groups.
  
  
  RESULTS
  The levels of NO and MDA in serum of patients with coal worker's Pneumoconiosis were higher than those in the controls; the level of SOD was lower in the patients than in the controls; and there were statistically significant differences between the two groups (P<0.05). Statistically significant differences in TGF-beta1 and FGF were also noted between the two group.
  
  
  CONCLUSIONS
  In this study, the patients with coal worker's Pneumoconiosis were found to have abnormity of oxyradical reaction, unblanced oxidation/antioxidation state, and abnormally high expression of cytokine, which might have relations with the occurrence and development of coal worker's Pneumoconiosis.
authors.affiliation: Department of Occupational Medicine, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Yao
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Wang
authors.forename: Mian-zhen
authors.initials: MZ
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Wang
mesh_terms: D000368:Aged; D003032:Coal Mining; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D016676:Macrophages, Alveolar / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D011009:Pneumoconiosis / Q000097:blood* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D009569:Nitric Oxide; D005346:Fibroblast Growth Factors; D013482:Superoxide Dismutase