title: Recombinant human erythropoietin in pediatric patients: efficacy in facilitating autologous blood donation in spinal deformity surgery.
abstract: Preoperative autologous blood donation (PABD) is a widely used practice in orthopaedic elective surgery, but many pediatric patients are unable to complete the program of pre-deposit. Twenty-three consecutive patients undergoing spinal surgery for scoliosis received 6 administrations of 10000U of recombinant human erythropoietin (rHuEpo). Preop hemoglobin (Hb) levels and the numbers of collected and of autologous and allogeneic blood transfused units were determined. These results were compared with a previously-operated group of 28 patients, who differed only by the absence of concomitant erythropoietin therapy. Significant higher numbers of collected blood units and Hb levels were measured, and all of the patients completed the PABD program. A significantly lower requirement for allogeneic blood in the <<rHuEpo-treated>> group was observed: 1 vs 9 patients (4.3%-32.1%; p < 0.001). The study documents the efficacy of rHuEpo in facilitating the completion of a PABD program and in reducing exposure to allogeneic blood in pediatric patients undergoing corrective spinal surgery.
authors.affiliation: Istituto di Clinica Ortopedica e Traumatologica-Università degli Studi di Verona.
authors.forename: D
authors.initials: D
authors.lastname: Regis
authors.forename: M
authors.initials: M
authors.lastname: Franchini
authors.forename: F
authors.initials: F
authors.lastname: Corallo
authors.forename: P
authors.initials: P
authors.lastname: Bartolozzi
mesh_terms: D000293:Adolescent; D001804:Blood Transfusion, Autologous / Q000379:methods*; D002648:Child; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D011300:Preoperative Care; D011994:Recombinant Proteins; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D012600:Scoliosis / Q000601:surgery* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin