Animal models of multiple system atrophy.
Multiple system atrophy (MSA) is a fatal neurodegenerative disorder presenting with autonomic failure and motor impairment, primarily comprising L-dopa-resistant parkinsonism but occasionally involving cerebellar ataxia. These features result from progressive multisystem neuronal loss that is associated with oligodendroglial alpha-synuclein inclusions. The growing number of animal models for MSA reflects the search for a preclinical test-bed for elucidating MSA pathogenesis and for developing novel therapeutic interventions. Here, the currently available MSA animal models will be reviewed and leads for future research will be identified.
Stefanova
Nadia
N
Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.
Tison
François
F
Reindl
Markus
M
Poewe
Werner
W
Wenning
Gregor K
GK
D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D019578:Multiple System Atrophy / Q000473:pathology* / Q000503:physiopathology; D051381:Rats