Impaired spatial coding within objects but not between objects in prosopagnosia.
BACKGROUND
Patients with prosopagnosia from occipitotemporal lesions have impaired perception of the configuration of facial features. This may be an example of impaired "within-object" spatial coding, which others propose to be distinct from "between-object" spatial coding.


OBJECTIVE
To determine whether the prosopagnosic deficit in perceiving spatial configuration was specific to within-face and not between-face spatial coding and whether the deficit was face-selective or extended to objects other than faces.


METHODS
Six prosopagnosic patients were tested using an oddity paradigm in which they detected which of three simultaneously seen stimuli was an altered target. In the "within-face" task, the target face had altered interocular distance or mouth position. In the "between-face" task, the target face was located farther away from the other two. In the "within-object" task, the stimulus was a two-dot pattern, and the target pattern had altered interdot distance.


RESULTS
Spatial judgments were impaired within faces for all six patients and within the two-dot pattern for five of six patients. However, all six had normal between-face spatial perception.


CONCLUSIONS
Impaired perception of spatial relations in prosopagnosia is selective to the spatial structure within individual objects and spares the perception of spatial location of objects. It is not specific to faces. It reveals a process involved in analyzing object structure, consistent with the patients' deficits in recognizing facial identity, and illustrates a different type of "visuospatial" defect.
Barton
Jason J S
JJ
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. jasonbarton@shaw.ca
Cherkasova
Mariya V
MV
D000328:Adult; D001925:Brain Damage, Chronic / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology; D005145:Face; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D020238:Prosopagnosia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D013028:Space Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*; D014795:Visual Pathways / Q000293:injuries / Q000473:pathology / Q000503:physiopathology