title: Amygdala reactivity to emotional faces predicts improvement in major depression.
abstract: Behavioral studies suggest that emotional reactivity in depressed persons predicts subsequent symptom reduction. Using functional magnetic resonance imaging in a prospective study, we show that greater amygdala activation to emotional facial expressions among depressed patients predicts symptom reduction 8 months later, controlling for initial depression severity and medication status. Functional magnetic resonance imaging may thus be used as a method to identify neural markers in depressed patients at risk for poor outcome.
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, NY 11794-2500, USA.
authors.forename: Turhan
authors.initials: T
authors.lastname: Canli
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Cooney
authors.forename: Philippe
authors.initials: P
authors.lastname: Goldin
authors.forename: Maulik
authors.initials: M
authors.lastname: Shah
authors.forename: Heidi
authors.initials: H
authors.lastname: Sivers
authors.forename: Moriah E
authors.initials: ME
authors.lastname: Thomason
authors.forename: Susan
authors.initials: S
authors.lastname: Whitfield-Gabrieli
authors.forename: John D E
authors.initials: JD
authors.lastname: Gabrieli
authors.forename: Ian H
authors.initials: IH
authors.lastname: Gotlib
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000098:blood supply / Q000503:physiopathology*; D003865:Major Depressive Disorder / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012306:Risk; D013997:Time Factors
chemical_list: D010100:Oxygen