Colon targeted delivery systems: review of polysaccharides for encapsulation and delivery.
Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon-based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. Recent research into the utilization of the metabolic activity and the colonic microenvironment in the lower gastrointestinal tract has attained great value in the design of novel colon-targeted delivery systems based on natural biodegradable polymers. In the current article, special emphasis has been placed on polysaccharide systems, with minimal chemical modification, that have been exploitedfor colon targeting. These polysaccharide based encapsulation and targeted delivery systems are envisaged to have an immense potential for the development of food/nutraceutical formulations for colon-based diseases, including colorectal cancer.
Kosaraju
Shantha L
SL
Food Science Australia, 671 Snydes Rd., Private Bag 16, Werribee, Victoria 3030, Australia. shantha.kosaraju@csiro.au
D000464:Alginates / Q000008:administration & dosage; D000688:Amylose / Q000008:administration & dosage; D000818:Animals; D002214:Capsules; D048271:Chitosan / Q000008:administration & dosage; D002809:Chondroitin Sulfates / Q000008:administration & dosage; D003106:Colon / Q000187:drug effects*; D003505:Cyclodextrins / Q000008:administration & dosage; D003911:Dextrans / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005685:Galactans / Q000008:administration & dosage; D006801:Humans; D007444:Inulin / Q000008:administration & dosage; D008351:Mannans / Q000008:administration & dosage; D010368:Pectins / Q000008:administration & dosage; D053149:Plant Gums; D011134:Polysaccharides / Q000008:administration & dosage*; D013213:Starch / Q000008:administration & dosage
D000464:Alginates; D002214:Capsules; D003505:Cyclodextrins; D003911:Dextrans; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; D010368:Pectins; D013213:Starch; D007444:Inulin; D000688:Amylose; D002809:Chondroitin Sulfates; D048271:Chitosan; C007894:guar gum