title: Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents.
abstract: A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. kidwai_chemistry@yahoo.co.uk
authors.forename: Mazaahir
authors.initials: M
authors.lastname: Kidwai
authors.forename: Shilpi
authors.initials: S
authors.lastname: Saxena
authors.forename: M Khalilur Rahman
authors.initials: MK
authors.lastname: Khan
authors.forename: Sharanjit S
authors.initials: SS
authors.lastname: Thukral
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002254:Carbonates; D004787:Environmental Pollution / Q000517:prevention & control; D004926:Escherichia coli / Q000187:drug effects; D008872:Microwaves; D011188:Potassium; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012996:Solutions; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D002254:Carbonates; D012996:Solutions; D014867:Water; C037593:potassium carbonate; D011188:Potassium