[Influence of basic fibroblast growth factors on the migration, proiferation of osteoblasts and periodontal ligament fibroblasts].
OBJECTIVE
In order to determine the influence of bFGF on the biological characteristics of osteoblasts and periodontal ligament cells, the author investigate the influence of bFGF on the migration, proliferation of osteoblasts and periodontal ligament fibroblasts between osteoblasts and fibroblasts.


METHODS
The forth generation of osteoblasts and periodontal ligament fibroblast were obtained and the wounding model in vitro of them was founded. The cells were cultured in mediums with or without bFGF. Their migration and proliferation were observed and measured.


RESULTS
Osteoblasts migrated faster than fibroblasts in common culture medium without bFGF and the periodontal ligament fibroblasts in culture medium with bFGF had higher migration rate than other groups. bFGF promoted the proliferation of both two kinds of cells.


CONCLUSIONS
bFGF could accelerate periodontal fibroblasts' proliferation and migration.
Tan
Zhen
Z
Key Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China.
Gong
Ping
P
Zhao
Qing
Q
D049109:Cell Proliferation; D002478:Cells, Cultured; D016222:Fibroblast Growth Factor 2; D005347:Fibroblasts; D010006:Osteoblasts; D010513:Periodontal Ligament
D016222:Fibroblast Growth Factor 2