title: Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atria.
abstract: Mechanism of chronic volume overload-induced AT.
  
  
  BACKGROUND
  Atrial dilatation associated with chronic volume overload (CVO) plays an important role in the development of atrial fibrillation (AF). However, the underlying mechanisms are unknown.
  
  
  RESULTS
  CVO-induced atrial dilatation was created in Japanese white rabbits using arteriovenous shunt formation for 6 weeks. Epicardial action potentials were measured from both atria in Langendorff-perfused sham-operated control hearts (n=8) and in CVO hearts (n=8) using high-resolution optical mapping techniques. The left atrial diameter was greater in CVO hearts (16.0+/-0.4 mm) compared to control hearts (11.0+/-0.8 mm). During steady-state pacing, right and left atrial conduction velocities were significantly lower in CVO hearts compared to control hearts (P<0.01). Rapid atrial pacing did not induce atrial tachyarrhythmia (AT) in any control hearts. However, in seven of eight CVO hearts 16 episodes of AT were induced, of which 9 exhibited a single reentrant circuit. The remaining 7 episodes exhibited a focal pattern of excitation without evidence of reentry. Interestingly, the activation rate was higher during reentry (16.1+/-1.5 Hz) compared to focal AT (9.8+/-1.0 Hz). In addition, 15 of 16 episodes occurred in the posterior left atrium (PLA). In all seven CVO hearts, AT was self-sustained for more than 10 minutes.
  
  
  CONCLUSIONS
  CVO caused atrial dilatation, conduction slowing, and AT associated with reentrant and focal excitation originating from the PLA. These results suggest that the PLA may play an important role in AT induction associated with CVO-induced atrial dilation.
authors.affiliation: Department of Molecular Pharmacology, Shinshu University School of Medicine, Nagano, Japan. hirose@sch.md.shinshu-u.ac.jp
authors.forename: Masamichi
authors.initials: M
authors.lastname: Hirose
authors.forename: Yasuchika
authors.initials: Y
authors.lastname: Takeishi
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Laurita
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Chiba
mesh_terms: D000818:Animals; D016275:Atrial Function; D002908:Chronic Disease; D004108:Dilatation, Pathologic; D004452:Echocardiography; D006325:Heart Atria; D006329:Heart Conduction System / Q000503:physiopathology; D006940:Hyperemia / Q000150:complications* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011817:Rabbits; D013610:Tachycardia / Q000209:etiology*; D013997:Time Factors; D016277:Ventricular Function, Left