title: 3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.
abstract: An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dukat
authors.forename: Anna
authors.initials: A
authors.lastname: Ramunno
authors.forename: Rita
authors.initials: R
authors.lastname: Banzi
authors.forename: M Imad
authors.initials: MI
authors.lastname: Damaj
authors.forename: Billy
authors.initials: B
authors.lastname: Martin
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
mesh_terms: D003460:Crystallization; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009538:Nicotine / Q000031:analogs & derivatives / Q000378:metabolism; D011485:Protein Binding; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism; D012997:Solvents; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D011725:Pyridines; D011978:Receptors, Nicotinic; D012997:Solvents; C403531:nicotinic receptor alpha4beta2; D009538:Nicotine