title: Reactive oxygen species and human inflammatory periodontal diseases.
abstract: Reactive oxygen species (ROS) have emerged as important signaling molecules in the regulation of various cellular processes. They can be generated by the mitochondrial electron transport chain in mitochondria and activation of polymorphonuclear leukocytes (PMN) during inflammatory conditions. Excessive generation of ROS may result in attack of and damage to most intracellular and extracellular components in a living organism. Moreover, ROS can directly induce and/or regulate apoptotic and necrotic cell death. Periodontal pathologies are inflammatory and degenerative diseases. Several forms of periodontal diseases are associated with activated PMN. Damage of tissues in inflammatory periodontal pathologies can be mediated by ROS resulting from the physiological activity of PMN during the phagocytosis of periodontopathic bacteria.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Atatürk University, 25240 Erzurum, Turkey. cfcanakci@yahoo.com
authors.forename: C F
authors.initials: CF
authors.lastname: Canakçi
authors.forename: Y
authors.initials: Y
authors.lastname: Ciçek
authors.forename: V
authors.initials: V
authors.lastname: Canakçi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D010510:Periodontal Diseases / Q000378:metabolism* / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species