Pro-inflammatory mediator leukotriene D4 induces transcriptional activity of potentially oncogenic genes.
The inflammatory mediator LTD4 (leukotriene D4) is present at high levels in many inflammatory conditions, and areas of chronic inflammation have an increased risk for subsequent cancer development. We demonstrate here that following LTD4 stimulation, beta-catenin is translocated to the nucleus, triggering the transcriptional activity of the TCF (T-cell factor)/LEF (lymphoid enhancer factor) family of transcription factors. These events are dependent on phosphoinositide-3 kinase activation and glycogen synthase kinase inhibition. Our data suggest that, similar to Wnt signalling, LTD4 increases free beta-catenin and targets it to the nucleus.
Mezhybovska
M
M
Experimental Pathology, Department of Laboratory Medicine, Lund University, University Hospital Malmö, Malmö SE-205 02, Sweden.
Wikström
K
K
Ohd
J F
JF
Sjölander
A
A
D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D015212:Inflammatory Bowel Diseases / Q000235:genetics; D017998:Leukotriene D4 / Q000502:physiology*; D009857:Oncogenes; D021381:Protein Transport; D014158:Transcription, Genetic
D017998:Leukotriene D4