title: The role of trivalent dimethylated arsenic in dimethylarsinic acid-promoted skin and lung tumorigenesis in mice: tumor-promoting action through the induction of oxidative stress.
abstract: We investigated the relationship between lung- and skin-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice. The incidence of lung tumors induced by lung tumor initiator (4NQO) and DMA(V) were, as well as 8-oxo-2'-deoxyguanosine (8-oxodG), suppressed by cotreatment with (-)epigallocatechin gallate (EGCG). When mice were topically treated with trivalent dimethylated arsenic (DMA(III)), a further reductive metabolite of DMA(V), not only an increase in skin tumors but also an elevation of 8-oxodG in epidermis were observed. These results suggest that tumor promotion due to DMA(V) administration is mediated by DMA(III) through the induction of oxidative stress.
authors.affiliation: Department of Environmental Toxicology and Carcinogenesis, Nihon University College of Pharmacy, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Mizoi
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Takabayashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakano
authors.forename: Yan
authors.initials: Y
authors.lastname: An
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sagesaka
authors.forename: Koichi
authors.initials: K
authors.lastname: Kato
authors.forename: Shoji
authors.initials: S
authors.lastname: Okada
authors.forename: Kenzo
authors.initials: K
authors.lastname: Yamanaka
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000236:Adenoma / Q000139:chemically induced* / Q000378:metabolism; D000287:Administration, Topical; D000818:Animals; D002101:Cacodylic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006540:Herbicides / Q000378:metabolism / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D018384:Oxidative Stress / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000378:metabolism
chemical_list: D002273:Carcinogens; D006540:Herbicides; C472511:dimethylarsinous acid; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002101:Cacodylic Acid; D003849:Deoxyguanosine