Myocardial regeneration by endogenous adult progenitor cells.
New strategies are urgently needed for the treatment of terminal heart-failure. Recently, new therapeutic strategies were developed to induce cardiac regeneration and thereby enhancing myocardial performance by using the patients own cell pool. In the quest for adequate donor cells skeletal myoblasts, bone marrow (BM) derived cells, endothelial progenitor cells (EPCs) and resident cardiac stem cells but also cytokine application were examined. This review critically discusses the recent findings in the field of endogenous adult progenitor cells and proposes new areas for future research.
Müller
Patrick
P
Klinik für Innere Medizin III, Kardiologie, Angiologie and internistische Intensivmedizin, Universität des Saarlandes, Kirrberger Strasse, D-66421 Homburg/Saar, Germany.
Beltrami
Antonio Paolo
AP
Cesselli
Daniela
D
Pfeiffer
Peter
P
Kazakov
Andrey
A
Böhm
Michael
M
D000328:Adult; D006801:Humans; D009206:Myocardium / Q000166:cytology* / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000166:cytology* / Q000473:pathology; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*