Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L.
Inhibition of HBsAg release against hepatitis B virus (HBV) was investigated in an aqueous extract prepared from the aerial parts (stems and leaves) of Agrimonia eupatoria. The inhibitory effect on HBsAg secretion was footed using aqueous extracts of Agrimonia eupatoria at four different temperatures (37 degrees C 45 degrees C, 55 degrees C and 60 degrees C), and the extract prepared at 60 degrees C was found to have the greatest effect. The inhibitory activity of Agrimonia eupatoria extracts on HBsAg secretion varied over the growing season and was the highest at mid-July. This inhibitory activity was also shown with the aqueous extracts of two other species of the genus Agrimonia: A. pilosa and A. coreana pilosella. These results suggest that some plants of the genus Agrimonia contain potential antiviral activity against HBV.
Kwon
Dur Han
DH
Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-333, Republic of Korea. dhkwon@kribb.re.kr
Kwon
Hyuk Yun
HY
Kim
Hyun Jung
HJ
Chang
Eun Joo
EJ
Kim
Man Bae
MB
Yoon
Seung Kew
SK
Song
Eun Young
EY
Yoon
Do Young
DY
Lee
Young Hee
YH
Choi
In Seong
IS
Choi
Yong Kyung
YK
D031981:Agrimonia; D002460:Cell Line; D006509:Hepatitis B / Q000188:drug therapy; D006514:Hepatitis B Surface Antigens / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects*; D006358:Hot Temperature; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems
D006514:Hepatitis B Surface Antigens; D010936:Plant Extracts