title: Bone morphogenetic protein 5 expression in the rat ovary: biological effects on granulosa cell proliferation and steroidogenesis.
abstract: Recently, the role of several elements of the bone morphogenetic protein (BMP) family has been studied in the ovary, some of them being crucial for ovarian function. In the present work, we have studied bone morphogenetic protein 5 (BMP5) expression and its biological role in the rat ovary. BMP5 is expressed by rat granulosa cells (GCs) and exerts specific biological effects on proliferation and steroidogenesis of these cells in an autocrine manner. These effects were shown to be associated with an increase in cyclin D2 protein level and a decrease in steroidogenic acute regulatory (StAR) protein expression in GCs in vitro. Ultimately, BMP5 actions were inhibited by follistatin. Overall, these data show that BMP5 is a novel element of the BMP family that might play a fully paracrine role in rodent ovarian folliculogenesis.
authors.affiliation: Physiologie de la Reproduction et des Comportements, UMR 6175 INRA-CNRS-Université F. Rabelais de Tours Haras Nationaux, 37380 Nouzilly, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Pierre
authors.forename: Claudine
authors.initials: C
authors.lastname: Pisselet
authors.forename: Joelle
authors.initials: J
authors.lastname: Dupont
authors.forename: Martine
authors.initials: M
authors.lastname: Bontoux
authors.forename: Philippe
authors.initials: P
authors.lastname: Monget
mesh_terms: D000818:Animals; D055417:Bone Morphogenetic Protein 5; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000187:drug effects / Q000378:metabolism; D056742:Cyclin D2; D016213:Cyclins / Q000187:drug effects / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D038681:Follistatin / Q000494:pharmacology; D005786:Gene Expression Regulation; D006107:Granulosa Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010053:Ovary; D010750:Phosphoproteins / Q000187:drug effects / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000378:metabolism*; D000098682:Steroidogenic Acute Regulatory Protein
chemical_list: D055417:Bone Morphogenetic Protein 5; D019485:Bone Morphogenetic Proteins; C486197:Ccnd2 protein, rat; D056742:Cyclin D2; D016213:Cyclins; D038681:Follistatin; D010750:Phosphoproteins; D012333:RNA, Messenger; D013256:Steroids; D000098682:Steroidogenic Acute Regulatory Protein; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D002786:Cholesterol Side-Chain Cleavage Enzyme