title: An independent confirmation of a quantitative trait locus for milk yield and composition traits on bovine chromosome 26.
abstract: Several reports have demonstrated that bovine chromosome 26 (BTA26) harbours significant or suggestive quantitative trait loci (QTL) for milk production and composition traits in dairy cattle. Our previous study showed that a C/T substitution in the bovine TCF7L2 gene on BTA26 was significantly linked to QTL for protein yield (PY) in a Canadian dairy cattle population. Actually, this polymorphism was one of the markers derived from a genome-wide screening of QTL for milk PY using an amplified fragment length polymorphism technique combined with a DNA pooling strategy. In the present study, 990 Holstein bulls with complete genotype and phenotype data from 14 sire families were analysed to confirm, if the QTL effects exist in other populations. Statistical analysis revealed that this marker was significantly associated with PY, protein percentage, milk yield and fat yield (FY) (p < 0.001) in the US Holstein population. These results indicate that this QTL region has a pleiotrophic effecton different milk traits and is portable in different populations.
authors.affiliation: Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USA. jiangz@wsu.edu
authors.forename: Z
authors.initials: Z
authors.lastname: Jiang
authors.forename: S
authors.initials: S
authors.lastname: De
authors.forename: M D
authors.initials: MD
authors.lastname: Garcia
authors.forename: K B
authors.initials: KB
authors.lastname: Griffin
authors.forename: X L
authors.initials: XL
authors.lastname: Wu
authors.forename: Q
authors.initials: Q
authors.lastname: Xiao
authors.forename: J J
authors.initials: JJ
authors.lastname: Michal
authors.forename: B S
authors.initials: BS
authors.lastname: Sharma
authors.forename: G B
authors.initials: GB
authors.lastname: Jansen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D004247:DNA / Q000737:chemistry; D005787:Gene Frequency; D005838:Genotype; D007774:Lactation / Q000235:genetics*; D008892:Milk / Q000737:chemistry* / Q000378:metabolism*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D040641:Quantitative Trait Loci; D051820:TCF Transcription Factors / Q000235:genetics* / Q000502:physiology; D058118:Transcription Factor 7-Like 2 Protein
chemical_list: D051820:TCF Transcription Factors; D058118:Transcription Factor 7-Like 2 Protein; D004247:DNA