title: Multiple scattering in optical coherence tomography. I. Investigation and modeling.
abstract: We present a new model of optical coherence tomography (OCT) taking into account multiple scattering. A theoretical analysis and experimental investigation reveals that in OCT, despite multiple scattering, the field backscattered from the sample is generally spatially coherent and that the resulting interference signal with the reference field is stationary relative to measurement time. On the basis of this result, we model an OCT signal as a sum of spatially coherent fields with random-phase arguments--constant during measurement time--caused by multiple scattering. We calculate the mean of such a random signal from classical results of statistical optics and a Monte Carlo simulation. OCT signals predicted by our model are in very good agreement with a depth scan measurement of a sample consisting of a mirror covered with an aqueous suspension of microspheres. We discuss other comprehensive OCT models based on the extended Huygens-Fresnel principle, which rest on the assumption of partially coherent interfering fields.
authors.affiliation: Laboratoire d'Optique Biomédicale, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland. boris.karamata@a3.epfl.ch
authors.forename: Boris
authors.initials: B
authors.lastname: Karamata
authors.forename: Markus
authors.initials: M
authors.lastname: Laubscher
authors.forename: Marcel
authors.initials: M
authors.lastname: Leutenegger
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bourquin
authors.forename: Theo
authors.initials: T
authors.lastname: Lasser
authors.forename: Patrick
authors.initials: P
authors.lastname: Lambelet
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008027:Light; D008954:Models, Biological; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence / Q000379:methods*