Antibiotics and ribosomes: interaction and resistance.
This session was convened by Dr Joyce Sutcliffe (Pfizer Central Research, Groton, CT, USA) and Dr R Leclerq (Hôpital Côte de Nacre, Caen, France), with the assistance of the Committee Member Advisor, Dr Patrice Courvalin (Institut Pasteur, Paris, France). It included several presentations in which recent advances on understanding interactions of antibiotics with the ribosome, and mechanisms of action of such drugs, were discussed. The majority of speakers focused on antibiotic interaction with the large ribosomal subunit. Exciting new developments in the field of ribosomal research were highlighted by publication, just several weeks before the conference, of high-resolution crystallographic structures of the large and small ribosomal subunits. With this in mind, several speakers discussed biochemical and genetic data on antibiotic-ribosome interactions within the context of newly available structural information.
Mankin
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University of Illinois, Center for Pharmaceutical Biotechnology, M/C 870, Chicago, IL 60607-7173, USA. shura@uic.edu