title: [Expression and significance of cyclin D1 in human adenoid cystic carcinoma].
abstract: OBJECTIVE
  To observe the expression of cyclin D1 in human adnoid cystic carcinoma and its correlation with clinical characters.
  
  
  METHODS
  The expression of cycline D1 was evaluated with immunohistochemical method in forty-one cases of human adnoid cystic carcinoma, 15 cases of PA and 12 cases of normal salivary gland tissue.
  
  
  RESULTS
  The expression of cyclin D1 in normal tissue was negative, significantly different from PA and ACC (P < 0.05). The expression level of PA was significantly lower than ACC (P < 0.05). High expression of cyclin D1 was correlated with clinical stage and histological classification (P < 0.05), but not with sex, age, tumor site, recurrence, metastasis.
  
  
  CONCLUSIONS
  High expression of cyclin D1 promotes the formation and development of ACC.
authors.affiliation: Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Xuan-Ping
authors.initials: XP
authors.lastname: Cao
authors.forename: Long-Jiang
authors.initials: LJ
authors.lastname: Li
mesh_terms: D002277:Carcinoma; D003528:Carcinoma, Adenoid Cystic; D019938:Cyclin D1; D005260:Female; D006801:Humans; D008875:Middle Aged; D012468:Salivary Gland Neoplasms
chemical_list: D019938:Cyclin D1