title: [A clinical study of non-erosive reflux disease].
abstract: OBJECTIVE
  [corrected] To investigate the differences and similarities between non-erosive reflux disease (NERD) and reflux disease (RE).
  
  
  METHODS
  This study covered 30 patients who were grouped by endoscopy into the cases of NERD (n=17) or RE (n=13). The two groups' symptom, mentality, and damage to life quality were compared. Biopsy was performed at 3 cm above LES in oesophagus. The patients were placed under ambulatory 24-h oesophageal pH and Bilitec2000 monitoring. And their responses to the same anti-reflux treatment were evaluated.
  
  
  RESULTS
  (1) The proportion of female (58.82%) in NERD group was much higher than that (15.38%) in RE group (P<0.05). (2) There was no remarkable difference in symptom, damage to life quality between the NERD and RE groups (P>0.05). But in respect to mentality, the NERD group had significantly higher anxiety and depression scores than did the RE group (P<0.05). (3) No noticeable difference in the pathological results of biopsy was seen between the NERD and RE groups (P>0.05). (4) The NERD group had less abnormal reflux, compared with the RE group (P<0.05). (5) The NERD group gave less response to treatment, compared to the RE group (P<0.05).
  
  
  CONCLUSIONS
  NERD may be a kind of reflux disease different from RE.
authors.affiliation: Department of Gastroenterology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Gong
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Xue-qin
authors.initials: XQ
authors.lastname: Wang
authors.forename: You-ling
authors.initials: YL
authors.lastname: Zhu
mesh_terms: D000328:Adult; D004947:Esophagus / Q000473:pathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male