Gastrin and cancer: a review.
In 1905, a Cambridge physiologist, John Sydney Edkins, initially identified a hormone responsible of gastric acid secretion, which he called gastric secretin, or gastrin. While gastrin's role in acid secretion is now well defined, more recent studies have implicated the various isoforms of gastrin in cancer. Important advances in the last decade have included the recognition of biological activity for processing intermediates such as progastrin and the glycine-extended gastrin. Here, we give an overview of the roles of these peptides in cancer, highlighted by molecular, cellular and integrated studies on animal models for progastrin-derived peptides and their receptors.
Ferrand
Audrey
A
IFR31, Institut Louis Bugnard, BP 84225, Unité INSERM 531, Biologie et Pathologie Digestives, 31432 TOULOUSE, Cedex 4, France. audrey.ferrand@toulouse.inserm.fr
Wang
Timothy C
TC
D000818:Animals; D005755:Gastrins / Q000235:genetics / Q000502:physiology*; D006728:Hormones / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D020033:Protein Isoforms / Q000502:physiology; D011498:Protein Precursors / Q000235:genetics; D015398:Signal Transduction
D005755:Gastrins; D006728:Hormones; D020033:Protein Isoforms; D011498:Protein Precursors; C013706:big gastrin