title: Monte Carlo simulation of light-tissue interaction: three-dimensional simulation for trans-illumination-based imaging of skin lesions.
abstract: Three-dimensional, voxel-based, and wavelength-dependent skin lesion models are developed and simulated using Monte Carlo techniques. The optical geometry of the Nevoscope with trans-illumination is used in the simulations for characterizing the lesion thickness. Based on the correlation analysis between the lesion thickness and the diffuse reflectance, optical wavelengths are selected for multispectral imaging of skin lesions using the Nevoscope. Tissue optical properties reported by various researchers are compiled together to form a voxel library. Tissue models used in the simulations are developed using the voxel library which offers flexibility in updating the optical properties and adding new media types into the models independent of the Monte Carlo simulation code.
authors.affiliation: Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
authors.forename: Sachin V
authors.initials: SV
authors.lastname: Patwardhan
authors.forename: Atam P
authors.initials: AP
authors.lastname: Dhawan
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Relue
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003198:Computer Simulation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D009506:Nevus / Q000473:pathology / Q000503:physiopathology; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D012878:Skin Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*