title: Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors.
abstract: In the continuation of efforts to modify the structure of our novel DP-IV inhibitors, a series of pyrazolidine derivatives with heteroaryl urea was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV).
authors.affiliation: Medicinal Science Division, Korea Research Institute of Chemical Technology, Taejon 305-600, Korea. jhahn@krict.re.kr
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Ahn
authors.forename: Sun Ho
authors.initials: SH
authors.lastname: Jung
authors.forename: Jin Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Seog Beom
authors.initials: SB
authors.lastname: Song
authors.forename: Soon Ji
authors.initials: SJ
authors.lastname: Kwon
authors.forename: Kwang Rok
authors.initials: KR
authors.lastname: Kim
authors.forename: Sang Dal
authors.initials: SD
authors.lastname: Rhee
authors.forename: Sung-Dae
authors.initials: SD
authors.lastname: Park
authors.forename: Jae Mok
authors.initials: JM
authors.lastname: Lee
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Hyae Gyeong
authors.initials: HG
authors.lastname: Cheon
mesh_terms: D000818:Animals; D018819:Dipeptidyl Peptidase 4 / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008810:Mice, Inbred C57BL; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D011480:Protease Inhibitors; D011720:Pyrazoles; D018819:Dipeptidyl Peptidase 4