Subacute oral toxicity study of diethylphthalate based on the draft protocol for "Enhanced OECD Test Guideline no. 407".
We performed a 28-day repeated-dose toxicity study of diethylphthalate based on the draft protocol of the "Enhanced OECD Test Guideline 407" to investigate whether it has endocrine-mediated properties according to this assay. Diethylphthalate was orally administered to SD rats at doses of 0, 40, 200, and 1,000 mg/kg/day for at least 28 days, but no endocrine-mediated effects were detected based on any of the parameters examined, suggesting that diethylphthalate does not possess endocrine properties according to this assay.
Shiraishi
Keiji
K
Chemicals Evaluation and Research Institute, 3-822 Ishii, Hita, Oita 877-0061, Japan.
Miyata
Katusi
K
Houshuyama
Satsuki
S
Imatanaka
Nobuya
N
Umano
Takaaki
T
Minobe
Yasushi
Y
Yamasaki
Kanji
K
D000284:Administration, Oral; D000313:Adrenal Medulla / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D019983:Guideline Adherence; D017408:Guidelines as Topic; D007441:Intubation, Gastrointestinal; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size; D010314:Partial Thromboplastin Time; D010795:Phthalic Acids / Q000008:administration & dosage / Q000633:toxicity*; D010968:Plasticizers / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D014554:Urination / Q000187:drug effects
D010795:Phthalic Acids; D010968:Plasticizers; C007379:diethyl phthalate