Ubiquitin and ubiquitin-like proteins as multifunctional signals.
Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins. The central structural element of these post-translational modifications is the ubiquitin superfold. A common ancestor based on this superfold has evolved to give various proteins that are involved in diverse activities in the cell.
Welchman
Rebecca L
RL
School of Biomedical Sciences,University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
Gordon
Colin
C
Mayer
R John
RJ
D000818:Animals; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism / Q000502:physiology*; D014452:Ubiquitins / Q000378:metabolism / Q000502:physiology*
D025801:Ubiquitin; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex