title: Heterotopic ossification related to toxic epidermal necrolysis in a patient with Behçet's disease.
abstract: We describe a 44-year-old woman with an 18-year-history of Behçet's disease (BD) in whom heterotopic ossification (HO) developed as a complication of toxic epidermal necrolysis (TEN). The patient presented with high fever, a progressive erythematous rash including target-like lesions, flaccid blister formations, and severe detachment. The patient was diagnosed with TEN, and methylprednisolone therapy was started. In the 2nd month of her hospital course, painful limitation developed in both her elbow and shoulder joints. Laboratory and radiographic findings confirmed HO of these areas. BD associated with TEN and HO is a previously unreported entity. In such a condition, determination of underlying genetic abnormality is important. Additionally, HO should be considered as a potential cause of the symptoms related to the joints.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Nehir
authors.initials: N
authors.lastname: Samanci
authors.forename: Nilufer
authors.initials: N
authors.lastname: Balci
authors.forename: Erkan
authors.initials: E
authors.lastname: Alpsoy
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D004551:Elbow Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D009999:Ossification, Heterotopic / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D026741:Physical Therapy Modalities; D011859:Radiography; D018570:Risk Assessment; D012720:Severity of Illness Index; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome; D014421:Turkey
chemical_list: D008775:Methylprednisolone