title: Tuberculosis, HIV seroprevalence and intravenous drug abuse in prisoners.
abstract: High rates of tuberculosis (TB) and HIV are believed to exist in Russian prisons. Prisoners with TB were studied in order to identify the following: 1) prevalence of HIV, and risk factors for HIV and other blood-borne virus infections; and 2) clinical and social factors that might compromise TB treatment effectiveness and/or patient adherence and, hence, encourage treatment failure. A 1-yr cross-sectional prevalence study of 1,345 prisoners with TB was conducted at an in-patient TB facility in Samara, Russian Federation. HIV and hepatitis B and/or C co-infection occurred in 12.2% and 24.1% of prisoners, respectively, and rates were significantly higher than in civilians. Overall, 48.6% of prisoners used drugs, of which 88.3% were intravenous users. Prisoners were more likely to be intravenous drug users and HIV positive compared with civilians with TB, and 40.2% of prisoners shared needles. Two-thirds of prisoners (68.6%) had received previous TB drug therapy (frequently multiple, interrupted courses) and were significantly more likely than civilians to have had previous therapy consistent with the high drug-resistance rates seen. Prisons are major drivers of the tuberculosis and HIV epidemics. Novel strategies are needed to reduce the spread of blood borne diseases, particularly in intravenous drug users.
authors.affiliation: HPA National Mycobacterium Reference Unit, Dept of Microbiology and Infection, King's College Hospital (Dulwich), East Dulwich Grove, London SE22 8QF, UK. francis.drobniewski@kcl.ac.uk
authors.forename: F A
authors.initials: FA
authors.lastname: Drobniewski
authors.forename: Y M
authors.initials: YM
authors.lastname: Balabanova
authors.forename: M C
authors.initials: MC
authors.lastname: Ruddy
authors.forename: C
authors.initials: C
authors.lastname: Graham
authors.forename: S I
authors.initials: SI
authors.lastname: Kuznetzov
authors.forename: G I
authors.initials: GI
authors.lastname: Gusarova
authors.forename: S M
authors.initials: SM
authors.lastname: Zakharova
authors.forename: A S
authors.initials: AS
authors.lastname: Melentyev
authors.forename: I M
authors.initials: IM
authors.lastname: Fedorin
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D005260:Female; D015528:HIV Seroprevalence; D006801:Humans; D008297:Male; D010349:Patient Compliance; D015995:Prevalence; D011329:Prisoners; D012307:Risk Factors; D012426:Russia; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy / Q000523:psychology
chemical_list: D000995:Antitubercular Agents