[Effect of family history and clinical features of metabolic syndrome on certain anthropometric, clinical, biochemical, metabolical parameters and the method of diabetes treatment in women with gestational diabetes].
Etiopathogenesis of gestational diabetes mellitus (GDM) is still unknown. It has been suggested, that GDM may be a clinical feature of the Metabolic Syndrome (MS). The aim of the study was to asses the effects of parents history of MS clinical features (diabetes mellitus type 2, obesity, arterial hypertension) on certain anthropometric measures, clinical, biochemical and metabolic parameters and on the method of GDM treatment. 156 GDM women aged from 19 to 43 years (mean +/- SD:29.7 +/- 5.8 years) were included in this study. They were divided into two groups, 73 women with positive family history and 83 with negative family history. These groups were compared with regard to age, time of diagnosis of GDM, BMI before pregnancy, increase of weight during pregnancy, fasting glycaemia, fasting insulinaemia, HBA1c, HOMA indices of insulin resistance and method of GDM treatment with regard to maximal doses of insulin used during pregnancy. All parameters except BMI were assessed at the diagnosis of GDM. Gestational diabetics with positive family history of MS clinical features were older (mean +/- SD:30.7 +/- 6.4 vs 28.9 +/- 5.2 years) and have a greater BMI before pregnancy (26.34 +/- 6.12 vs 23.31 +/- 4.7 kg/m2) with GDM diagnosed earlier (29.3 +/- 3.5 vs 30.7 +/- 3.4 week) than in the gestational diabetics with negative family history. There were not significant differences between groups in fasting glycaemia, fasting insulinaemia, increase in weight during pregnancy at GDM diagnosis, HbA1c, HOMA-IR and maximal dose of insulin during pregnancy. There were significant positive correlation between age and BMI in women without family between age and BMI in positive family history group. In both groups were not correlations between age, time of GDM diagnosis and BMI. In positive family history 52% of women were treated with insulin during pregnancy. In negative family history 37% of women were treated with insulin.


CONCLUSIONS
positive one or both parents history of MS clinical features (diabetes mellitus type 2, obesity, arterial hypertension) my be predisposing cause of greater BMI before pregnancy, earlier diagnosis of GDM and more frequently insulin treatment during pregnancy comparing with gestational diabetics with negative family history of analyzed MS clinical features.
Sokup
Alina
A
Katedra i Klinika Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych, Akademii Medycznej w Bydgoszczy. alinasokup@o2.pl
Tyloch
Małgorzata
M
Szymański
Wiesław
W
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000235:genetics* / Q000503:physiopathology*; D011247:Pregnancy; D012307:Risk Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C025617:glucosylated hemoglobin A