[Role of platelet activating factor in hepatorenal syndrome].
OBJECTIVE
To investigate the relationship between platelet activating factor (PAF) and occurrence of hepatorenal syndrome (HRS).


METHODS
A total of 57 cases of patients with liver cirrhosis or hepatitis gravis were enrolled. The serum concentrations of PAF, lipopolysaccharide (LPS) and prothrombin activity (PTA), total bilirubin, and serum creatinine were detected in patients combined with HRS and in patients without HRS in hospital at the term. The correlations among the PAF, LPS, and the function of liver and kidney were analyzed.


RESULTS
The concentrations of PAF and LPS in the patients combined with HRS were significantly higher than those patients without HRS. There were linear correlations between the PAF and LPS level, the total bilirubin level and PAF level, the PAF level and serum creatinine level.


CONCLUSIONS
The PAF associates with the occurrence of HRS. The PAF may mediate the occurrence of HRS induced by LPS. The PAF level may forecast whether patients with liver failure will take place HRS.
Xie
De-Sheng
DS
Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.
Xie
Yu-Tao
YT
D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006530:Hepatorenal Syndrome / Q000378:metabolism*; D006801:Humans; D008297:Male; D010972:Platelet Activating Factor / Q000378:metabolism*
D015415:Biomarkers; D010972:Platelet Activating Factor