The production of hydrogen peroxide during early-stage protein aggregation: a common pathological mechanism in different neurodegenerative diseases?
By means of an ESR spin-trapping method, we have shown that Abeta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
Tabner
B J
BJ
Magnetic Resonance Laboratory, University of Lancaster, Lancaster LA1 4YQ, UK.
Turnbull
S
S
Fullwood
N J
NJ
German
M
M
Allsop
D
D
D000682:Amyloid / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D009410:Nerve Degeneration / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D010455:Peptides
D000682:Amyloid; D005609:Free Radicals; D010455:Peptides; D006861:Hydrogen Peroxide