Ketogenic diet increases calbindin-D28k in the hippocampi of male ICR mice with kainic acid seizures.
The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These results suggest that the neuroprotective effect of the KD on the KA-induced toxicity may be, in part, mediated via an increased expression of CB.
Noh
Hae Sook
HS
Department of Anatomy and Neurobiology, Institute of Health Science, College of Medicine, Gyeongsang National University, 92 Chilam-dong, Chinju, Kyungnam 660-751, Republic of Korea.
Kang
Sang Soo
SS
Kim
Dong Wook
DW
Kim
Young Hee
YH
Park
Chang Hwan
CH
Han
Jae Yoon
JY
Cho
Gyeong Jae
GJ
Choi
Wan Sung
WS
D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D005526:Food, Formulated; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D007608:Kainic Acid; D007657:Ketone Bodies / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
C576499:Calb1 protein, mouse; D064092:Calbindin 1; D064026:Calbindins; D007657:Ketone Bodies; D064030:S100 Calcium Binding Protein G; D007608:Kainic Acid