title: Bioassay-guided isolation of antimicrobial benzopyrans and phloroglucinol derivatives from Hypericum species.
abstract: Recently the crude methanol extracts of six Hypericum species were analysed against a panel of microorganisms and it was found that H. caprifoliatum Cham. & Schlecht., H. myrianthum Cham. & Schlecht. and H. polyanthemum Klotzsch ex Reichardt were the most active. This paper reports the activity of the hexane, chloroform and methanol fractions of these plants as well as the activity of some isolated compounds against Staphylococcus aureus determined by bioautographic procedures.
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS. Av. Ipiranga, 2752, 90610-000 Porto Alegre, RS, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Dall'agnol
authors.forename: Alexandre
authors.initials: A
authors.lastname: Ferraz
authors.forename: Ana P
authors.initials: AP
authors.lastname: Bernardi
authors.forename: Daniela
authors.initials: D
authors.lastname: Albring
authors.forename: Carolina
authors.initials: C
authors.lastname: Nör
authors.forename: Elfrides E S
authors.initials: EE
authors.lastname: Schapoval
authors.forename: Gilsane L
authors.initials: GL
authors.lastname: von Poser
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001578:Benzopyrans / Q000737:chemistry; D001681:Biological Assay / Q000379:methods; D006801:Humans; D020902:Hypericum; D008826:Microbial Sensitivity Tests; D010696:Phloroglucinol / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D010936:Plant Extracts; D010696:Phloroglucinol