[Use of sodium hypochlorite in therapy for acute intoxications with methemoglobin formers].
The study of these intoxications has demonstrated that the blood level of methemoglobin (MH) is in conformity with the severity of intoxication. The pathospecific therapeutic effect of sodium hypochlorite (SHC) in acute intoxications of varying severity has been found to appear as a significant intensification of demethemoglobinization and as a three-fold reduction in the half-life of MH. The nonspecific effect of SHC manifests itself in correcting metabolic acidosis and in improving blood oxygenation. The use of SHC accelerates the regression of clinical manifestations of disease and reduces the length of inpatient treatment.
Petrov
S I
SI
El'kov
A N
AN
Luzhnikov
E A
EA
Gol'dfarb
Iu S
IuS
Il'iashenko
K K
KK
Belova
M B
MB
D000293:Adolescent; D000328:Adult; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008706:Methemoglobin / Q000032:analysis*; D008708:Methemoglobinemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D011041:Poisoning / Q000097:blood / Q000150:complications / Q000188:drug therapy; D012973:Sodium Hypochlorite / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D000931:Antidotes; D008706:Methemoglobin; D012973:Sodium Hypochlorite