"Corination" of the proANP converting enzyme.
The membrane protease, corin, has been shown to be the proatrial natriuretic peptide (ANP)-converting enzyme. Like mice lacking ANP, corin-deficient animals are hypertensive and have cardiac hypertrophy.
Potter
Lincoln R
LR
Deparment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000737:chemistry* / Q000235:genetics*; D001794:Blood Pressure; D006332:Cardiomegaly / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D012697:Serine Endopeptidases / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
D018076:DNA, Complementary; D006728:Hormones; D010455:Peptides; D009320:Atrial Natriuretic Factor; C485617:Corin protein, mouse; D012697:Serine Endopeptidases