title: Exercise-induced changes in mitral regurgitation in patients with prior myocardial infarction and left ventricular dysfunction: relation to mitral deformation and left ventricular function and shape.
abstract: OBJECTIVE
  The aim of this study was to assess the relationship between exercise-induced changes in mitral regurgitation (MR) and echocardiographic characteristics of mitral deformation, global left ventricular (LV) function and shape at rest and after exercise.
  
  
  RESULTS
  Forty consecutive patients with ischaemic MR due to prior myocardial infarction (MI), ejection fraction <45% in sinus rhythm underwent exercise-echocardiographic testing. Exercise-induced changes in effective regurgitant orifice (ERO) were compared with baseline and exercise-induced changes in mitral deformation and global LV function and shape. There was significant correlation between exercise-induced changes in ERO and changes in coaptation distance (r=0.80, P<0.0001), tenting area (r=0.79, P<0.0001) and mitral annular diameter (r=0.65, P<0.0001), as well as in end-systolic sphericity index (r=-0.50, P=0.001, respectively), and wall motion score index (r=0.44, P=0.004). In contrast, exercise-induced changes in ERO were not related to the echocardiographic features at rest. By stepwise multiple regression model, the exercise-induced changes in mitral deformation were found to independently correlate with exercise-induced changes in ERO (generalized r(2)=0.80, P<0.0001).
  
  
  CONCLUSIONS
  Exercise-induced changes in severity of ischaemic MR in patients with LV dysfunction due to prior MI were independently related to changes in mitral deformation.
authors.affiliation: Department for Diagnostic and Catheterization Laboratories, Institute for Cardiovascular Disease, Clinical Center of Serbia, 8 Koste Todorovica, 11000 Belgrade, Yugoslavia.
authors.forename: Vojislav
authors.initials: V
authors.lastname: Giga
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojic
authors.forename: Bosiljka
authors.initials: B
authors.lastname: Vujisic-Tesic
authors.forename: Ana
authors.initials: A
authors.lastname: Djordjevic-Dikic
authors.forename: Jelena
authors.initials: J
authors.lastname: Stepanovic
authors.forename: Branko
authors.initials: B
authors.lastname: Beleslin
authors.forename: Milan
authors.initials: M
authors.lastname: Petrovic
authors.forename: Milan
authors.initials: M
authors.lastname: Nedeljkovic
authors.forename: Ivana
authors.initials: I
authors.lastname: Nedeljkovic
authors.forename: Natasa
authors.initials: N
authors.lastname: Milic
mesh_terms: D025401:Echocardiography, Stress; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000473:pathology* / Q000503:physiopathology; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology