Social defeat: risk factor for schizophrenia?
The hypothesis that chronic and long-term experience of 'social defeat' may increase the risk for schizophrenia is proposed. This increased risk may result from sensitisation of the mesolimbic dopamine system and/or increased baseline activity of this system. Data supporting the social defeat hypothesis are presented.
Selten
Jean-Paul
JP
Cantor-Graae
Elizabeth
E
D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000378:metabolism; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000208:ethnology / Q000209:etiology* / Q000378:metabolism; D012930:Social Dominance; D012931:Social Environment; D014171:Transients and Migrants / Q000523:psychology
D015259:Dopamine Agents; D004298:Dopamine