Evolution of the NadR regulon in Enterobacteriaceae.
The NAD biosynthetic pathway and NAD transformations in E. coli and S. typhi are well characterized. Using comparative genomics methods we describe the NadR regulon in other Enterobacteriaceae, identity new candidate regulon members and demonstrate that even a very simple regulon covering an essential methabolic pathway could be different in closely related genomes.
Gerasimova
Anna V
AV
Laboratory of Bioinformatics, State Scientific Center GOSNIIGenetika, 1-iy Dorozhny proezd 1, Moscow, 113545, Russia. a_gerasimova@yahoo.com
Gelfand
Mikhail S
MS
D001426:Bacterial Proteins / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D004269:DNA, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D018085:Regulon / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*; D013045:Species Specificity
D001426:Bacterial Proteins; D004269:DNA, Bacterial; C117105:NadR protein, bacteria; D012097:Repressor Proteins