Assessment of PINK1 (PARK6) polymorphisms in Finnish PD.
Recent data has demonstrated that mutations in PINK1, encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK1 contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population.
Clarimón
Jordi
J
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35 Room 1A1000, MSC 3707, Bethesda, MD 20892, USA. clarimon@mail.nih.gov
Eerola
Johanna
J
Hellström
Olli
O
Peuralinna
Terhi
T
Tienari
Pentti J
PJ
Singleton
Andrew B
AB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase