title: Auditory processing deficits in unilaterally and bilaterally injured hypoxic-ischemic rats.
abstract: Hypoxic-ischemic represents a common cause of damage to the prenatal brain and can co-occur with prematurity. Prematurity is associated with emergent language impairments, and it has been suggested that rapid auditory processing deficits play a causal role in language difficulties. We previously demonstrated rapid auditory processing deficits in juvenile rats receiving neonatal unilateral hypoxic-ischemic injury, but these deficits appeared to resolve by adulthood. The current study compared unilaterally and bilaterally injured hypoxic-ischemic rats on auditory tasks, to assess whether rapid auditory processing recovery in adulthood is related to this aspect of injury. Current results indicate that while neonatal unilateral and bilateral hypoxic-ischemic injury both lead to rapid auditory processing deficits in the juvenile period, only rats with bilateral hypoxic-ischemic injury exhibit deficits that persist into adulthood.
authors.affiliation: Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, Storrs, Connecticut, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: McClure
authors.forename: Steven W
authors.initials: SW
authors.lastname: Threlkeld
authors.forename: Glenn D
authors.initials: GD
authors.lastname: Rosen
authors.forename: R
authors.initials: R
authors.lastname: Holly Fitch
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001308:Auditory Perceptual Disorders / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000254:growth & development / Q000473:pathology; D004307:Dose-Response Relationship, Radiation; D007839:Functional Laterality; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000502:physiology; D013997:Time Factors