title: Therapeutic immunization of highly active antiretroviral therapy-treated HIV-1-infected patients: safety and immunogenicity of an HIV-1 gag/poly-epitope DNA vaccine.
abstract: In view of the global emergency posed by lack of access to highly active antiretroviral therapy (HAART) and the limitations of current drug regimens, alternative therapeutic strategies are urgently needed. Cellular immune responses elicited by HIV-1 exert some control over virus replication, therefore the enhancement of HIV-1-specific responses by therapeutic vaccination might lead to viral containment without HAART. We evaluated the safety and immunogenicity, in HIV-1-infected individuals under HAART suppression, of a DNA vaccine, pTHr.HIVA.
authors.affiliation: MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
authors.forename: Lucy
authors.initials: L
authors.lastname: Dorrell
authors.forename: Hongbing
authors.initials: H
authors.lastname: Yang
authors.forename: Astrid Kn
authors.initials: AK
authors.lastname: Iversen
authors.forename: Christopher
authors.initials: C
authors.lastname: Conlon
authors.forename: Annie
authors.initials: A
authors.lastname: Suttill
authors.forename: Mary
authors.initials: M
authors.lastname: Lancaster
authors.forename: Tao
authors.initials: T
authors.lastname: Dong
authors.forename: Inese
authors.initials: I
authors.lastname: Cebere
authors.forename: Anne
authors.initials: A
authors.lastname: Edwards
authors.forename: Sarah
authors.initials: S
authors.lastname: Rowland-Jones
authors.forename: Tomás
authors.initials: T
authors.lastname: Hanke
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McMichael
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D004341:Drug Evaluation; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005260:Female; D015750:Genes, gag / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D000939:Epitopes; D019444:Vaccines, DNA; C509463:pTHr.HIVA