title: Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung.
abstract: This study investigated the relation between positive thyroid transcription factor 1 (TTF1) staining and survival of patients affected by primary adenocarcinoma (ADC) of the lung. Pathological tissue from consecutive ADC patients was collected from 2002 to 2004. The anti-TTF1 antibody (8G7G3/1, dilution of 1/200) was used. Thyroid transcription factor 1 staining was assessed for each tumour as positive or negative. Probability of survival was estimated by Kaplan-Meier and difference tested by log-rank test. A Cox's regression multivariate analysis was carried out. In all, 106 patients were studied (66% male, 69% PS0-1, 83% with stage III or IV). Tumours expressed positive TTF1 staining in 66% of cases. Multivariate analysis demonstrated an independent lower risk of death for patients whose tumour expresses positive TTF1 staining (HR = 0.51, 95% CI 0.30-0.85; P = 0.01) and higher grade of differentiation (HR = 0.40, 95% CI 0.24-0.68; P = 0.001). In conclusion, positive TTF1 staining strongly and independently correlates with survival of patients with primary ADC of the lung.
authors.affiliation: Faculty of Medicine - Assistance Publique Hôpitaux de Marseille, Department of Thoracic Oncology, Fédération des Maladies Respiratoires, Hôpital Sainte-Marguerite, Marseille, France. fabrice.barlesi@mail.ap-hm.fr
authors.forename: F
authors.initials: F
authors.lastname: Barlési
authors.forename: D
authors.initials: D
authors.lastname: Pinot
authors.forename: A
authors.initials: A
authors.lastname: Legoffic
authors.forename: C
authors.initials: C
authors.lastname: Doddoli
authors.forename: B
authors.initials: B
authors.lastname: Chetaille
authors.forename: J-P
authors.initials: JP
authors.lastname: Torre
authors.forename: P
authors.initials: P
authors.lastname: Astoul
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016019:Survival Analysis; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors