Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension.
The association of 4 genetic polymorphisms, NAD(P)H oxidase, manganesesuperoxide dismutase (MnSOD), catalase, and endothelial nitric oxide synthase (e-NOS), was assessed with arsenic-related hypertension risk among 79 hypertensive cases and 213 controls in an arseniasis-hyperendemic area of Taiwan. Overall, MnSOD polymorphism significantly increased the risk of hypertension regardless of arsenic exposure. NADPH oxidase and eNOS polymorphisms were significantly associated with hypertension risk in the high arsenic exposure group; however, catalase polymorphism was not associated with hypertension. Groups were further stratified by triglyceride levels to evaluate whether the cumulative arsenic exposure combined the three polymorphisms together. The adjusted adds ratios (ORs) of at least two risk factors of the cumulative arsenic exposure and MnSOD, NADPH oxidase, and eNOS three-polymorphism combination versus any one risk factor of them were 0.8 (95% CI 0.3-2.3) for individuals with low triglyceride levels (<110 mg/dl) and 2.5 (95% CI 1.0-6.01) for high-triglyceride groups (>110 mg/dl), respectively. These results suggested that the NADPH oxidase, MnSOD, and e-NOS polymorphisms, but not catalase, might play a role in the development of arsenic-related hypertension, especially in subjects with high triglyceride levels.
Hsueh
Yu-Mei
YM
Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan. ymhsueh@tmu.edu.tw
Lin
Pinpin
P
Chen
Hui-Wen
HW
Shiue
Horng-Sheng
HS
Chung
Chi-Jung
CJ
Tsai
Chiao-Tzu
CT
Huang
Yung-Kay
YK
Chiou
Hung-Yi
HY
Chen
Chien-Jen
CJ
D000328:Adult; D001151:Arsenic / Q000633:toxicity*; D002374:Catalase / Q000235:genetics; D004781:Environmental Exposure; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*; D011795:Surveys and Questionnaires; D013624:Taiwan; D014881:Water Supply
D002374:Catalase; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D013482:Superoxide Dismutase; D019255:NADPH Oxidases; D001151:Arsenic