Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay.
Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.
Seib
Kate L
KL
The School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia.
Simons
Mark P
MP
Wu
Hsing-Ju
HJ
McEwan
Alastair G
AG
Nauseef
William M
WM
Apicella
Michael A
MA
Jennings
Michael P
MP
D001681:Biological Assay; D002470:Cell Survival; D006069:Gonorrhea / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism* / Q000382:microbiology*; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*