DISC1 and neurocognitive function in schizophrenia.
We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%-4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia.
Burdick
Katherine E
KE
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA. kburdick@lij.edu
Hodgkinson
Colin A
CA
Szeszko
Philip R
PR
Lencz
Todd
T
Ekholm
Jenny M
JM
Kane
John M
JM
Goldman
David
D
Malhotra
Anil K
AK
D000328:Adult; D000704:Analysis of Variance; D003071:Cognition / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012306:Risk; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*; D014706:Verbal Learning / Q000502:physiology
C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins