[Antibodies to retinal S antigen in the tear and serum as an indicator of the nature of a course of endogenous uveitis in children].
Antibodies (IgM and IgG) to retinal S antigen were studied by enzyme immunoassay in the tear (n = 135) and blood serum (n = 221) samples taken from 45 children with chronic endogenous uveitis during a follow-up (for 6 months to 5 years). The studies have confirmed the early evidence that detection of serum autoantibodies may be used for the diagnosis of autoimmune and infectious-and-autoimmune uveitis, the verification and prediction of renal alterations, risks for lesions in the second eye in unilateral uveitis and prerecurrence in bilateral uveitis. Criteria for detecting antibodies to lacrimal S antigen were developed. Its has been ascertained that it is expedient to use this procedure as a method for controlling the efficiency of treatment in uveitis involving the posterior parts of the eye, confirming, and predicting the risk for involvement of the retina into an inflammatory process, detecting trends for development of chronic forms of both bilateral and unilateral uveitis. Simultaneous accumulation of IgM and/or IgG antibodies in the lacrimal fluid and serum, as well as imbalance, i.e. a prolonged enhancement of only local or only systemic response to S antigen (of both classes), are prognostically unfavorable.
Slepova
O S
OS
Katargina
L A
LA
Sidorova
T V
TV
Bykovskaia
G N
GN
Zueva
M V
MV
Tsapenko
I V
IV
Shevchenko
T F
TF
Ostrovskiĭ
M A
MA
Kalamkarov
G R
GR
D000293:Adolescent; D019393:Arrestin / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D011379:Prognosis; D013666:Tears / Q000276:immunology*; D013997:Time Factors; D014605:Uveitis / Q000276:immunology* / Q000378:metabolism
D019393:Arrestin; D001323:Autoantibodies; D015415:Biomarkers