Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides.
Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.
Menzies
Barbara E
BE
Veterans Affairs Puget Sound Health Care System, S-111-ID, 1660 S. Columbian Way, Seattle, WA 98108, USA. bmenzies@u.washington.edu
Kenoyer
Aimee
A
D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis / Q000235:genetics*; D004817:Epidermis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000378:metabolism; D013203:Staphylococcal Infections / Q000378:metabolism*; D013211:Staphylococcus aureus; D013682:Teichoic Acids / Q000378:metabolism
D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid