Out of synch: Clock mutation causes obesity in mice.
The Clock gene encodes an essential component of the "master clock" driving circadian rhythm in the hypothalamic suprachiasmatic nucleus (SCN). New evidence that Clock mutant mice are hyperphagic and obese suggests a previously unrecognized link between molecular controls of circadian rhythm and energy homeostasis.
Williams
Diana L
DL
Department of Medicine, Harborview Medical Center, and University of Washington, Seattle, Washington 98104, USA.
Schwartz
Michael W
MW
D000818:Animals; D056926:CLOCK Proteins; D051379:Mice; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism
D015534:Trans-Activators; D056926:CLOCK Proteins; C538944:Clock protein, mouse