title: [Animal experimental study of the treatment of periapical disease with recombinant human bone morphogenetic protein-2 composite].
abstract: OBJECTIVE
  To investigate the effect of the treatment of periapical diseases with recombinant human netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application.
  
  
  METHODS
  The endotoxin-bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical were built. The rhBMP-2 composite was mixed by rhBMP-2, TCP, collagen and metronidazole and used in the treatment cal diseases in dog models as root apex screen. The imageology and pathology research were went on.
  
  
  RESULTS
  The effective rate of the experimental group was remarkably higher than that of the carrier group and the control group with remarkable ference (P < 0.05). The quality of the repair of tissue was obviously better than the two other groups.
  
  
  CONCLUSIONS
  The rhBMP-2 composite is a promising biological root-canal filling material.
authors.affiliation: Dept. of Dentistry, Affiliated Hospital of the Medical College, Hangzhou Teachers College, Hangzhou 310015, China.
authors.forename: Huo-Guang
authors.initials: HG
authors.lastname: Peng
authors.forename: Zhu-Ping
authors.initials: ZP
authors.lastname: Wang
authors.forename: Ting-Yan
authors.initials: TY
authors.lastname: Liu
authors.forename: Duo
authors.initials: D
authors.lastname: Wang
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D003094:Collagen; D004285:Dogs; D006801:Humans; D010483:Periapical Diseases; D011994:Recombinant Proteins; D012387:Root Canal Filling Materials; D016212:Transforming Growth Factor beta
chemical_list: D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D012387:Root Canal Filling Materials; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen