title: Common carotid intima-media thickness measurement is not a pertinent predictor for secondary cardiovascular events after coronary bypass surgery. A prospective study.
abstract: OBJECTIVE
  We aimed to assess the utility of common carotid intima-media thickness (CCA-IMT) to predict secondary cardiovascular events after coronary artery bypass grafting (CABG). In primary prevention, carotid-IMT is known as a valuable cardiovascular risk marker, but its interest in secondary prevention has been less studied. We hypothesized that CCA-IMT could be used for peri-operative and long-term risk stratification in candidates for CABG.
  
  
  METHODS
  A total of 609 patients (66.8+/-9.2 years) were prospectively enrolled for preoperative CCA-IMT measurement and follow-up. The primary end-point combined cardiovascular death, non-fatal acute coronary syndromes, stroke, secondary coronary revascularization and peripheral arterial surgery during follow-up. The secondary end-point was the 1-month post-operative death. Univariate and multivariate analysis were performed by usual methods.
  
  
  RESULTS
  A subgroup of 150 patients (24.6%) was individualized with a CCA-IMT above 90th percentile (>0.90 mm) or presenting plaques in their CCA. At 1 month, there was no significant difference in the prevalence of elevated CCA-IMT between deceased patients and survivors (16.7 vs. 24.9%, P=ns). During a mean follow-up of 41.8+/-16 months, 121 patients (19.8%) met the primary end-point. High CCA-IMT was predictive (OR=1.67, 95% CI 1.14-2.46, P=0.009) in the univariate analysis. In the multivariate analysis, age (OR=1.03, 95% CI 1.00-1.05, P=0.029) concomitant valvular surgery (OR=2.17, P=0.003) arrhythmia (OR=2.20, P=0.021), and peripheral arterial disease (OR=2.41, P<0.001) were significant independent prognostic factors whereas CCA-IMT failed to remain independently significant.
  
  
  CONCLUSIONS
  Pre-operative CCA-IMT can provide prognostic information for candidates to CABG. However, clinical data present stronger prognostic values.
authors.affiliation: Department of Thoracic & Cardiovascular Surgery and Vascular Medicine, Dupuytren University Hospital, 2 Avenue Martin Luther King, Limoges 87042, France. aboyans@unilim.fr
authors.forename: Victor
authors.initials: V
authors.lastname: Aboyans
authors.forename: Jérôme
authors.initials: J
authors.lastname: Guilloux
authors.forename: Philippe
authors.initials: P
authors.lastname: Lacroix
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yildiz
authors.forename: Annabel
authors.initials: A
authors.lastname: Postil
authors.forename: Marc
authors.initials: M
authors.lastname: Laskar
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000150:complications; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography