Holding the line on hepatic fat.
When chronically elevated, insulin increases hepatic lipogenesis and VLDL synthesis. However, the hormone reduces liver lipids when acutely elevated. Work in this issue of Cell Metabolism (Najjar at al., 2005) suggests a new mechanism for the inhibition of the rate-limiting enzyme in liver, fatty acid synthase.
Saltiel
Alan R
AR
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D004789:Enzyme Activation; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005234:Fatty Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D007328:Insulin / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D011485:Protein Binding
D015703:Antigens, CD; C069847:CD66 antigens; D002272:Carcinoembryonic Antigen; C486183:Ceacam1 protein, mouse; D015815:Cell Adhesion Molecules; D007328:Insulin; D064429:Fatty Acid Synthases