title: [Comparative study of the physical dependence on proline analog of dermorphin and morphine].
abstract: On the model of acute physical dependence, naloxone treatment of animals dependent on D-Pro6 peptide ([D-Pro6]DM) (a demorphin analog) led to tremor, shaking, convulsions, and rare jumps typical of morphine-dependent animals. The variety and intensity of reactions depended on the naloxone dose and the interval between naloxone and peptide injections. In the state of reject syndrome upon peptide and morphine subchronic treatments according to identical schedules, the symptoms in [D-Pro6]DM dependent animals were much less pronounced than in morphine-dependent ones.
authors.forename: L S
authors.initials: LS
authors.lastname: Guzevatykh
authors.forename: D V
authors.initials: DV
authors.lastname: Valuĭskikh
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: T G
authors.initials: TG
authors.lastname: Emel'ianova
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Alfeeva
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000008:administration & dosage / Q000633:toxicity*; D009021:Morphine Dependence / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009842:Oligopeptides / Q000008:administration & dosage / Q000633:toxicity*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
chemical_list: D009292:Narcotic Antagonists; D009842:Oligopeptides; C480702:dermorphin, (DPro(6))-; D009270:Naloxone; D009020:Morphine