The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits.
The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided into three groups: control, Al-only and Al+DE. The Al-only and Al+DE animals received injections of Al2(SO43.18H2O 600 micromol Al/kg 5 days per week for 3 weeks. One week after the last Al injection the Al+DE rabbits were given deferiprone 750 micromol/kg/day intragastrically for 2 weeks. At the 42nd day the animals were sacrificed and the organs were taken and digested. Blood was taken from the ear artery three times (at the initiation of the experiment, before and after deferiprone administration). The aluminum and copper, zinc, manganese were determined by atomic absorption spectrophotometry. Our results showed that deferiprone could highly mobilize aluminum stores from tissues. At the end of experiment the aluminum contents of bone, kidney, liver and brain in Al+DE were significantly lower than that in Al-only rabbits. The copper, zinc, manganese contents were not affected by deferiprone administration.
Liu
Ping
P
Department of Chemistry and Microbacteria Detection, College of Public Health, Shandong University, Wenhuaxilu 44, Jinan 250012, PR China.
Yao
Yu-Na
YN
Wu
Shi-De
SD
Dong
Huai-Jun
HJ
Feng
Guo-Chang
GC
Yuan
Xiao-Yan
XY
D000535:Aluminum / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000097:blood / Q000378:metabolism*; D000077543:Deferiprone; D008345:Manganese / Q000097:blood / Q000378:metabolism*; D011728:Pyridones / Q000494:pharmacology*; D011817:Rabbits; D013057:Spectrum Analysis; D015032:Zinc / Q000097:blood / Q000378:metabolism*
D011728:Pyridones; D000077543:Deferiprone; D008345:Manganese; D003300:Copper; D000535:Aluminum; D015032:Zinc