Vascular engineering for bypass surgery.
Since the introduction of synthetic vascular grafts in the 1960s, only two-stage endothelial cell seeding has demonstrated any significant improvement over conventional vascular grafts, and its benefits have yet to be demonstrated on a large scale. Tissue engineering is a rapidly expanding field with great potential, but efforts to construct tissue-engineered arterial grafts have, to date, yielded little clinical success. This review explores the latest approaches to the construction of a superior vascular graft, along with its potential for use in the clinic in the future.
Daly
Chris D
CD
University of Queensland, Centre for Research in Vascular Biology, 4072, QLD, Australia.
Campbell
Gordon R
GR
Walker
Phillip J
PJ
Campbell
Julie H
JH
D000818:Animals; D001808:Blood Vessels / Q000637:transplantation; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D023822:Tissue Engineering; D014656:Vascular Surgical Procedures / Q000379:methods