title: Lymphoma with large-plaque parapsoriasis treated with PUVA.
abstract: We report on a 78-year-old Japanese woman with a 50-year history of large-plaque parapsoriasis that had evolved into cutaneous T-cell lymphoma. Her large-plaque parapsoriasis had been treated with psoralen plus ultraviolet A for 10 years. Subsequently an isolated nodule appeared on her right lower leg. Prior or concurrent patches or plaques were absent. Histology revealed a diffuse nonepidermotropic infiltrate of large lymphocytes in the dermis, which had enlarged nuclei and prominent nucleoli. A diagnosis of CD30- cutaneous large T-cell lymphoma was made. Following systemic chemotherapy, there was clinical improvement. No evidence of recurrence or systemic lymphoma has subsequently been found.
authors.affiliation: Department of Dermatology, Department of Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science. 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan. risat@koto.kpu-m.ac.jp
authors.forename: Risa
authors.initials: R
authors.lastname: Tamagawa
authors.forename: Norito
authors.initials: N
authors.lastname: Katoh
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shimazaki
authors.forename: Akira
authors.initials: A
authors.lastname: Okano
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Kaori
authors.initials: K
authors.lastname: Ichihashi
authors.forename: Koji
authors.initials: K
authors.lastname: Masuda
authors.forename: Saburo
authors.initials: S
authors.lastname: Kishimoto
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D035002:Lower Extremity; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D011701:PUVA Therapy; D011565:Psoriasis / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology