title: Intralesional fibrous septum in chordoma: a clinicopathologic and immunohistochemical study of 122 lesions.
abstract: Intralesional fibrous septum (IFS) generally is considered a reactive tissue in chordoma; however, little is known about its significance. We studied 122 chordomas for IFS using immunohistochemical techniques and compared IFS and lobular growth patterns (LGPs) formed by IFS with clinicopathologic parameters. Seventy-nine tumors (64.8%) revealed IFS. However, IFS frequently was infiltrated and interrupted by tumor cells with increased expression of proteases; only 33 (42%) of 79 tumors had LGP. In non-skull base chordomas, IFS and LGP were associated with nuclear pleomorphism, a previously described prognostic indicator, mitosis, and the MIB-1 labeling index, indicating a role of IFS and LGP in tumor growth or progression. Paradoxically, patients without LGP tended to have a worse prognosis than those with LGP. We believe that IFS exerts diverse influences on chordoma; however, invasion of IFS leading to loss of the LGP indicates advanced stages of tumor development, possibly predicting an unfavorable prognosis in chordoma.
authors.affiliation: Department of Pathology, Faculty of Medicine, Magdeburg University, Magdeburg, Germany.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Naka
authors.forename: Carsten
authors.initials: C
authors.lastname: Boltze
authors.forename: Doerthe
authors.initials: D
authors.lastname: Kuester
authors.forename: Amir
authors.initials: A
authors.lastname: Samii
authors.forename: Christian
authors.initials: C
authors.lastname: Herold
authors.forename: Helmut
authors.initials: H
authors.lastname: Ostertag
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
authors.forename: Albert
authors.initials: A
authors.lastname: Roessner
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002817:Chordoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D005355:Fibrosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D011379:Prognosis
chemical_list: D019394:Ki-67 Antigen; D010447:Peptide Hydrolases