Rapid synthesis of cyclopropane-dipeptide analogues.
The synthesis of cyclopropane-substituted nitrile-dipeptides is reported. The straightforward transformation of the nitrile function into an amide or methylketone function leads to dipeptide analogues of potentially interesting pharmacologic profile.
McMath
Andrew
A
Laboratoire de Chimie Thérapeutique, Amiens, France.
Guillaume
Dominique
D
D000596:Amino Acids; D003521:Cyclopropanes / Q000138:chemical synthesis*; D004151:Dipeptides / Q000138:chemical synthesis; D004791:Enzyme Inhibitors / Q000494:pharmacology
D000596:Amino Acids; D003521:Cyclopropanes; D004151:Dipeptides; D004791:Enzyme Inhibitors; C030797:cyclopropane