Genetic linkage of a novel autosomal dominant restrictive cardiomyopathy locus.
BACKGROUND
In recent years, non-syndromic idiopathic cardiomyopathies have increasingly been characterised as autosomal dominant conditions caused by single gene mutations. Loci have been identified for hypertrophic and dilated cardiomyopathy, and in some cases the same loci are associated with restrictive cardiomyopathy (RCM). In a kindred with RCM that we previously reported, we ruled out the known cardiomyopathy loci and other candidate genes by linkage analysis and mutation screening.


RESULTS
Here we report a genome-wide analysis in this family that has resulted in linkage to a region on chromosome 10.


CONCLUSIONS
There are no genes in the interval that are known to cause idiopathic cardiomyopathy, and thus this linkage represents localisation of a new RCM locus.
Zhang
J
J
Kumar
A
A
Kaplan
L
L
Fricker
F J
FJ
Wallace
M R
MR
D002313:Cardiomyopathy, Restrictive / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree
D005819:Genetic Markers