[Immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid on perennial allergic rhinitis].
OBJECTIVE
To observe the immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with perennial allergic rhinitis.


METHODS
Sixty patients with perennial allergic rhinitis were randomly divided into two groups, 30 in the test group were treated with BCG-PSN plus ketotefen and 30 in the control group were treated with ketotefen respectively. All patients were followed up and assessed for 3 months, and the blood samples were collected before treatment and 3 months after treatment for measuring the blood IgA, IgG, IgM, IgE, CD3, CD4 and CD8.


RESULTS
In the test group, the total effective rate was significantly higher comparable to that in the control group. After treatment of BCG-PSN, blood CD3, CD4 and CD4/CD8 were significantly increased. IgE significantly reduced (P < 0.05).


CONCLUSIONS
BCG polysaccharides nucleic acid can modulate the cellular immunofunction of patients with perennial allergic rhinitis and can increase the curative rate on perennial allergic rhinitis.
Tang
Siquan
S
Department of Otorhinolaryngology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China. tangsiqu@126.com
Zhao
Bingling
B
Zhang
Guoyuan
G
Liu
Longyue
L
Zhou
Tianming
T
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000737:chemistry*; D009696:Nucleic Acids / Q000627:therapeutic use; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D011135:Polysaccharides, Bacterial