title: [Damage of genetic material in somatic cells of mice exposed to low doses of X-rays].
abstract: Pzh:SFIS mice were exposed during 8 weeks, 5 days per week to doses of 0.05 Gy; 0.10 Gy; 0.20 Gy of X-rays. Samples were taken at 24 h and at 72 h after the end of irradiation for micronucleus test, in the case of estimation induction of DNA damages also at 24 h and at 1, 4 and 8 weeks. Subchronic exposure of mice to low doses of ionizing radiation induced damages of genetic material of theirs somatic cells. The enhanced frequency of micronuclei were observed in reticulocytes and polychromatic erythrocytes of bone marrow after each of dose. Subchronic exposure to X-rays induced also DNA single strand breaks in bone marrow lymphocytes. Damage were observed up to 8 weeks after the end of exposure. Results obtained in this study confirmed sensitivity of bone marrow cells to low doses of X-rays.
authors.affiliation: Zakład Ochrony Radiologicznej i Radiobiologii, Państwowy Zakład Higieny, 00-791 Warszawa.
authors.forename: Małgorzata M
authors.initials: MM
authors.lastname: Dobrzyńska
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D015162:Micronucleus Tests; D013997:Time Factors; D014916:Whole-Body Irradiation; D014965:X-Rays / Q000009:adverse effects*