title: Serosal involvement in gastrointestinal cancer: its assessment and significance.
abstract: There is an increasing burden upon diagnostic histopathologists to identify accurately factors of prognostic and therapeutic implication in gastrointestinal cancer. It is perhaps partly because of the use of rigid sequential staging systems, such as the Dukes' classification, that some factors, perhaps most notably involvement of surgical margins (especially in rectal cancer) and serosal involvement (particularly in oesophageal, colonic and rectal cancer), have been relatively neglected until more recently. This is surprising and concerning because both of these pathologically derived parameters strongly correlate with subsequent locoregional recurrence and, ultimately, with prognosis. Whilst the occurrence and significance of serosal involvement have been well recognized in gastric cancer for many years, relatively little attention has been paid to the phenomenon in oesophageal cancer and yet both pleural and peritoneal involvement may be comparatively commonly identified in oesophageal cancer. Serosal involvement and transperitoneal spread are also of considerable prognostic importance in primary appendiceal carcinoma. Only more recently has the significance of serosal involvement been appreciated in colonic and rectal cancer. In the colon, the phenomenon is now recognized to be one of the most important factors in predicting transperitoneal spread and overall prognosis. Furthermore, there is increasing interest in alternative novel strategies, including intraperitoneal chemotherapy and radical peritoneal surgery, as legitimate therapeutic options in many gastrointestinal cancers.
authors.affiliation: Department of Histopathology, Gloucestershire Royal Hospital, Gloucester, UK.
authors.forename: L
authors.initials: L
authors.lastname: Ludeman
authors.forename: N A
authors.initials: NA
authors.lastname: Shepherd
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D010537:Peritoneum / Q000473:pathology*; D010994:Pleura / Q000473:pathology; D011379:Prognosis