3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes?
3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 microM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).
Chomcheon
Porntep
P
Program of Biotechnology and Department of Chemistry, Faculty of Science, Chulalongkorn University, Thailand.
Wiyakrutta
Suthep
S
Sriubolmas
Nongluksna
N
Ngamrojanavanich
Nattaya
N
Isarangkul
Duangnate
D
Kittakoop
Prasat
P
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis / Q000737:chemistry; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009574:Nitro Compounds; D010946:Plants, Medicinal; D011422:Propionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013785:Thailand
D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D015415:Biomarkers; D009574:Nitro Compounds; D011422:Propionates; C015392:3-nitropropionic acid