Do regulatory T cells play a role in the control of homeostatic proliferation?
The control of peripheral lymphocyte numbers is a fundamental aspect of the immune system. Regulatory T cells are involved in the suppression of autoimmune, antitumor, allergic, and other inflammatory responses, as well as in facilitating graft acceptance. In this paper, we discuss whether the control of homeostatic proliferation is another facet of the immune system that is controlled by regulatory T cells. A review of the published data connecting regulatory T cells with the control of homeostatic proliferation indicates that several key questions remain open. One of these relates to the stage at which regulatory T cells could play a role (i.e., T-cell proliferation vs. survival).
Curotto de Lafaille
Maria A
MA
Molecular Pathogenesis Progam, Skirball Institute of Biomolecular Medicine, and Department of Pathology, New York University School of Medicine, New York 10016, USA.
Shen
Shiqian
S
Olivares-Villagómez
Danyvid
D
Camps-Ramírez
Marlin
M
Lafaille
Juan J
JJ
D002455:Cell Division / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D015851:Interleukin-7; D016212:Transforming Growth Factor beta