title: Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study.
abstract: Hyperhomocysteinemia is a risk factor for ischemic stroke. We investigated five functional polymorphisms involved in homocysteine metabolism in each 159 stroke patients and controls. The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043). This study suggests that the investigated polymorphisms are no major risk factors for stroke, although MTHFR c. 677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies.
authors.affiliation: Department of Neurology, University Hospital Bonn, Bonn, Germany. michael.linnebank@ukb.uni-bonn.de
authors.forename: M
authors.initials: M
authors.lastname: Linnebank
authors.forename: M
authors.initials: M
authors.lastname: Montenarh
authors.forename: H
authors.initials: H
authors.lastname: Kölsch
authors.forename: A
authors.initials: A
authors.lastname: Linnebank
authors.forename: K
authors.initials: K
authors.lastname: Schnez
authors.forename: D
authors.initials: D
authors.lastname: Schweichel
authors.forename: C
authors.initials: C
authors.lastname: Pohl
authors.forename: H
authors.initials: H
authors.lastname: Urbach
authors.forename: R
authors.initials: R
authors.lastname: Heun
authors.forename: U
authors.initials: U
authors.lastname: Harbrecht
authors.forename: T
authors.initials: T
authors.lastname: Klockgether
authors.forename: U
authors.initials: U
authors.lastname: Wüllner
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D016001:Confidence Intervals; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006710:Homocysteine / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D012333:RNA, Messenger / Q000096:biosynthesis; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D020521:Stroke / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2)