[Electroencephalography measures in motor skill learning and effects of bromazepam].
Neuromodulators change brain's neural circuitry. Bromazepam is often been used in the pharmacological treatment of anxiety disorders. Few papers links this anxiolytic to motor tasks. The purpose of this study was to examine motor and electrophysiological changes produced by administration of bromazepam in differents doses (3 and 6 mg). The sample consisted of 39 healthy individuals, of both sexes, between 20 and 30 years of age. The control (placebo) and experimental (bromazepam 3mg and bromazepam 6 mg) groups were submitted to a typewriting task, in a randomized, double-blind design. The results did not reveal differences on score and time of the attention test. In the comportamental analysis was noticed blocks as main effect to behavioral variables (time and mistakes in the task). Electrophysiological data showed significants interactions to: laterally/condition/moment; laterally/condition; laterally/moment; condition/moment; condition/site.
Bastos
Victor Hugo
VH
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Brazil. victorhvbastos@uol.com.br
Machado
Dionis
D
Cunha
Marlo
M
Portella
Claudio Elidio
CE
Cagy
Maurício
M
Furtado
Vernon
V
Piedade
Roberto
R
Ribeiro
Pedro
P
D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001960:Bromazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006225:Hand / Q000502:physiology; D006801:Humans; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009048:Motor Skills / Q000187:drug effects* / Q000502:physiology
D014151:Anti-Anxiety Agents; D001960:Bromazepam