Identification of variant-specific surface proteins in Giardia muris trophozoites.
Giardia lamblia undergoes antigenic variation, a process that might allow the parasite to evade the host's immune response and adapt to different environments. Here we show that Giardia muris, a related species that naturally infects rodents, possesses multiple variant-specific surface proteins (VSPs) and expresses VSPs on its surface, suggesting that it undergoes antigenic variation similar to that of G. lamblia.
Ropolo
Andrea S
AS
Cátedra de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Nacional de Córdoba, Haya de la Torre S/N, Pabellón Argentina 2do piso, Ciudad Universitaria, CP 5000 Córdoba, Argentina.
Saura
Alicia
A
Carranza
Pedro G
PG
Lujan
Hugo D
HD
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D005872:Giardia / Q000235:genetics / Q000276:immunology*; D005873:Giardiasis / Q000276:immunology*; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D051381:Rats; D017208:Rats, Wistar
D008565:Membrane Proteins