title: Antioxidant activity of aryltetralone lignans and derivatives from Virola sebifera (Aubl.).
abstract: Aryltetralone lignans bearing methylenedioxy groups (1a-b; 2a-b) were isolated from seeds of Virola sebifera. Their antioxidant activities were evaluated by inhibition of lipid peroxidation as indicated by TBARS and chemiluminescence emission (CL) assays. The lignan 1c, 'having a 2'-hydroxy-4',5'-methylenedioxyphenyl group, was the most active compound with TBARS/CL Q 1/2 values of 0.89 and 0.10 microg/mL, respectively. The catechol derivatives 3 and 4, obtained by demethylenation of lignans 1a and 2a, were of similar activity to 1c, and all were much more effective as antioxidants than alpha-tocopherol.
authors.affiliation: Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil.
authors.forename: Kênnia R
authors.initials: KR
authors.lastname: Rezende
authors.forename: Solange C
authors.initials: SC
authors.lastname: Davino
authors.forename: Sílvia B M
authors.initials: SB
authors.lastname: Barros
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D026324:Myristicaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D017705:Lignans