title: Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome.
abstract: BACKGROUND
  Associations between hyperuricemia, cardiovascular diseases and diabetes have been reported, but few of the studies have been conducted in the Korean population. The present study examined a Korean adult population with respect to the relationships between serum uric acid concentrations and hypertension, insulin resistance, and the risk factors of metabolic syndrome.
  
  
  RESULTS
  A total of 53,477 subjects were divided into 4 groups according to serum uric acid quartiles. The incidence of hypertension in all subjects was higher in the first quartile than in the third plus fourth quartile (odds ratio (OR) 1.192, p < 0.001). Homeostasis model assessment index was found to be associated with serum uric acid concentration in all subjects (OR 1.193, p < 0.001), and the serum uric acid concentration was positively correlated with the risk factors of metabolic syndrome. In addition, the number of metabolic syndrome variables increased as serum uric acid concentration increased.
  
  
  CONCLUSIONS
  Serum uric acid concentration was found to be independently correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome. In addition, even those with a serum uric acid concentration in the normal range showed an increased risk of metabolic syndrome as serum uric acid concentration increased.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Yoo
authors.forename: Ki Chul
authors.initials: KC
authors.lastname: Sung
authors.forename: Hun Sub
authors.initials: HS
authors.lastname: Shin
authors.forename: Byung Jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Bum Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Kang
authors.forename: Man Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Jung Ro
authors.initials: JR
authors.lastname: Park
authors.forename: Hyang
authors.initials: H
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Won Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Dong Geuk
authors.initials: DG
authors.lastname: Keum
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid