title: IS26-associated In4-type integrons forming multiresistance loci in enterobacterial plasmids.
abstract: Three distinct multiresistant loci from enterobacterial plasmids each comprised an integron and an IS26-associated sequence. Sequence comparison suggested a common ancestral structure that derived from an IS26 insertion into the 5' conserved segment of an In4-type integron and evolved through acquisition of gene cassettes and IS26-mediated recruitment of additional resistance genes of diverse origin.
authors.affiliation: Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas. Sofias 127, Athens 11521, Greece. miriagou@mail.pasteur.gr
authors.forename: Vivi
authors.initials: V
authors.lastname: Miriagou
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
authors.forename: Eva
authors.initials: E
authors.lastname: Tzelepi
authors.forename: Laura
authors.initials: L
authors.lastname: Villa
authors.forename: Leonidas S
authors.initials: LS
authors.lastname: Tzouvelekis
mesh_terms: D003001:Cloning, Molecular; D004251:DNA Transposable Elements / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000187:drug effects / Q000235:genetics*; D019143:Evolution, Molecular; D032023:Integrons / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA
chemical_list: D004251:DNA Transposable Elements