title: Effects of silver nanoparticles on the fluidity of bilayer in phospholipid liposome.
abstract: This paper describes the formation and characterization of liposome entrapping the silver nanoparticles in bilayer. Silver nanoparticles were entrapped in the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposome, named as silver-loaded liposome. Specifically, above the gel to liquid-crystalline phase transition temperature of this lipid (i.e., 41 degrees C), it was observed that membrane fluidities of silver-loaded liposomes were increased, and fluorescence anisotropy values were reduced from 0.114 to 0.097. This might be due to the structural modifications and interactions between DPPC molecules and silver nanoparticles within the bilayer. It was also confirmed that silver nanoparticles were entrapped in hydrophobic region of lipid bilayer with transmission electron microscopy (TEM) and electron energy loss spectroscopy (EELS) measurements.
authors.affiliation: Department of Chemical Engineering, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Park
authors.forename: Seong-Geun
authors.initials: SG
authors.lastname: Oh
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Mun
authors.forename: Sung-Sik
authors.initials: SS
authors.lastname: Han
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D016880:Anisotropy; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry; D005454:Fluorescence Polarization; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D008560:Membrane Fluidity; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers; D012834:Silver / Q000737:chemistry*; D013053:Spectrophotometry; D013696:Temperature
chemical_list: D004337:Drug Carriers; D008051:Lipid Bilayers; D008081:Liposomes; D011108:Polymers; C422409:liquid crystal polymer; D015060:1,2-Dipalmitoylphosphatidylcholine; D012834:Silver