title: Intracoronary continuous adenosine infusion.
abstract: BACKGROUND
  Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined.
  
  
  RESULTS
  Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured after 3 dosages of IC adenosine infusion (180, 240 and 300 microg/min) in 30 patients. The phase II study was performed to compare the hyperemic efficacy of IC infusion (240 microg/min) with IC bolus injection (40, 80 microg) and intravenous (IV) infusion (140 microg x kg (-1) x min(-1)) of adenosine in 20 patients. In the phase I study, no significant differences in FFR were observed with the 3 different doses of IC infusion (p = 0.06). In the phase II study, FFR after an IC bolus injection (0.83+/-0.06) was significantly higher than with IV (0.79+/-0.07) or IC (0.78+/-0.09) infusion (p < 0.01). However, no difference in FFR was observed for IC and IV infusions.
  
  
  CONCLUSIONS
  IC infusion of adenosine seems to be a safe and effective method of inducing maximal hyperemia for FFR measurement.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center, Seoul.
authors.forename: Bon-Kwon
authors.initials: BK
authors.lastname: Koo
authors.forename: Cheol-Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Na
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Youn
authors.forename: In-Ho
authors.initials: IH
authors.lastname: Chae
authors.forename: Dong-Ju
authors.initials: DJ
authors.lastname: Choi
authors.forename: Hyo-Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Myoung-Mook
authors.initials: MM
authors.lastname: Lee
authors.forename: Byung-Hee
authors.initials: BH
authors.lastname: Oh
authors.forename: Young-Bae
authors.initials: YB
authors.lastname: Park
authors.forename: Yun-Shik
authors.initials: YS
authors.lastname: Choi
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Tahk
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D023921:Coronary Stenosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced*; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged
chemical_list: D000241:Adenosine