Synthesis of (+)-sulcatine G.
The total synthesis of (+)-sulcatine G is described. A key structural feature of sulcatine G is the highly functionalized, enantiomerically pure cyclobutane ring. We have prepared (+)-sulcatine G using a new strategy for bicyclic ring construction, Rh-mediated intramolecular C-H insertion followed by intramolecular alkylation.
Taber
Douglass F
DF
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA. taberdf@udel.edu
Frankowski
Kevin J
KJ
D000478:Alkylation; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry; D001487:Basidiomycota / Q000737:chemistry; D003500:Cyclization; D004952:Esters / Q000737:chemistry; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*
D000935:Antifungal Agents; D004952:Esters; D012717:Sesquiterpenes; C467820:sulcatine G