title: Orbital meningioma with a granular cell component in a dog, with extracranial metastasis.
abstract: A meningioma with a significant component of granular cells is described in the left ocular orbit of a 5-year-old male Golden retriever dog that presented with exophthalmos. The neoplastic mass surrounded the optic nerve. Microscopically, the tumour was characterized by nests of large, round to polygonal cells, variable in size, with eccentric nuclei and abundant eosinophilic cytoplasm, containing PAS-positive granules. In focal areas, cells were smaller and occasionally formed whorl-like structures. Immunohistochemical analysis revealed that neoplastic cells reacted positively for vimentin and, with less intensity, for neuron specific enolase and S-100, whereas they were negative for glial fibrillary acidic protein and cytokeratins. Metastatic growths, formed by similar cells, were seen in the lung and heart.
authors.affiliation: Departamento de Patología Animal: Medicina Animal (Anatomía Patológica), Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Pérez
authors.forename: E
authors.initials: E
authors.lastname: Vidal
authors.forename: N
authors.initials: N
authors.lastname: González
authors.forename: J
authors.initials: J
authors.lastname: Benavides
authors.forename: M C
authors.initials: MC
authors.lastname: Ferreras
authors.forename: M
authors.initials: M
authors.lastname: Villagrasa
authors.forename: M
authors.initials: M
authors.lastname: Pumarola
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D003594:Cytoplasmic Granules / Q000378:metabolism; D004283:Dog Diseases; D004285:Dogs; D037901:Euthanasia, Animal; D005094:Exophthalmos / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D017809:Fatal Outcome; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008579:Meningioma / Q000737:chemistry / Q000150:complications / Q000556:secondary / Q000662:veterinary*; D009918:Orbital Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D010503:Periodic Acid-Schiff Reaction / Q000662:veterinary; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase