Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners.
A series of C-4-anilino- and C-4-imido-substituted new podophyllotoxin congeners have been designed, synthesized, and evaluated for their cytotoxicity and DNA topoisomerase-II (topo-II) inhibition potential. Some of these compounds have exhibited promising in vitro anticancer and topo-II inhibition activity.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, Andhra Pradesh, India. ahmedkamal@iict.res.in
Gayatri
N Lakshmi
NL
Reddy
D Rajasekhar
DR
Mohan Reddy
P S Murali
PS
Arifuddin
M
M
Dastidar
Sunanda G
SG
Kondapi
Anand K
AK
Rajkumar
M
M
D000814:Aniline Compounds / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007094:Imides / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors
D000814:Aniline Compounds; D000970:Antineoplastic Agents; D007094:Imides; D011355:Prodrugs; D059005:Topoisomerase II Inhibitors; D011034:Podophyllotoxin; C023650:aniline