title: Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosis.
abstract: BACKGROUND
  Markers of cardiac injury, including troponin-T (TnT), are used to diagnose acute coronary syndrome (ACS); however, markers for plaque instability may be more useful for diagnosing ACS at the earliest stage. Lectin-like oxidized LDL receptor-1 (LOX-1) appears to play crucial roles in the pathogenesis of atherosclerotic plaque rupture and ACS onset. LOX-1 is released in part as soluble LOX-1 (sLOX-1) by proteolytic cleavage.
  
  
  RESULTS
  We examined serum sLOX-1 levels in 521 patients, consisting of 427 consecutive patients undergoing coronary angiography, including 80 ACS patients, 173 symptomatic coronary heart disease patients, 122 patients with significant coronary stenosis without ischemia, and 52 patients without apparent coronary atherosclerosis plus 34 patients with noncardiac acute illness and 60 patients with noncardiac chronic illness. Time-dependent changes in sLOX-1 and TnT levels were analyzed in an additional 40 ACS patients. Serum sLOX-1 levels were significantly higher in ACS than the other groups and were associated with ACS as shown by multivariable logistic regression analyses. Given a cutoff value of 1.0 ng/mL, sLOX-1 can discriminate ACS from other groups with 81% and 75% of sensitivity and specificity, respectively. sLOX-1 can also discriminate ACS without ST elevation or abnormal Q waves and ACS without TnT elevation from non-ACS with 91% and 83% of sensitivity, respectively. Peak values of sLOX-1 in ACS were observed earlier than those of TnT.
  
  
  CONCLUSIONS
  sLOX-1 appears to be a useful marker for early diagnosis of ACS.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Hayashida
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kume
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Murase
authors.forename: Manabu
authors.initials: M
authors.lastname: Minami
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakagawa
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Inada
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Akira
authors.initials: A
authors.lastname: Ueda
authors.forename: Goro
authors.initials: G
authors.lastname: Kominami
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kambara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D037102:Lectins / Q000097:blood; D008297:Male; D008875:Middle Aged; D051127:Scavenger Receptors, Class E / Q000097:blood*
chemical_list: D015415:Biomarkers; D037102:Lectins; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E