title: Twenty years of percutaneous treatments for cystic echinococcosis: a preliminary assessment of their use and safety.
abstract: Image-guided percutaneous treatments for echinococcal cysts were introduced in the mid-eighties. Today they represent a third therapeutic option, after surgery and benzimidazole derivatives. Two types of percutaneous treatments are available, based on the destruction of the germinal layer or the evacuation of the endocyst. To assess the extent of their use and their safety, a Medline search of the literature on this subject was performed. The number of cysts treated, their anatomical sites, the complications and, length of follow-up (when available), were all examined. The results show that percutaneous treatments for cystic echinococcosis are safe and efficacious in selected anatomical sites, provided basic safety issues are correctly addressed. However, before drawing final conclusions, a more detailed analysis of the literature is needed. Percutaneous treatments could be simplified and made more effective if a scolecidal agent could be found that melts the entire endocyst without causing harm to the biliary epithelium.
authors.affiliation: Divisione di Malattie Infettive e Tropicali, IRCCS San Matteo, University of Pavia, Italy. selim@unipv.it
authors.forename: E
authors.initials: E
authors.lastname: Brunetti
authors.forename: G
authors.initials: G
authors.lastname: Troia
authors.forename: A L
authors.initials: AL
authors.lastname: Garlaschelli
authors.forename: R
authors.initials: R
authors.lastname: Gulizia
authors.forename: C
authors.initials: C
authors.lastname: Filice
mesh_terms: D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D001658:Biliary Fistula / Q000209:etiology; D017115:Catheter Ablation / Q000009:adverse effects / Q000295:instrumentation; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004443:Echinococcosis / Q000188:drug therapy / Q000601:surgery*; D004444:Echinococcosis, Hepatic / Q000188:drug therapy / Q000601:surgery; D048209:Echinococcus granulosus / Q000187:drug effects / Q000254:growth & development; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D007814:Larva; D007902:Length of Stay; D008100:Liver Abscess / Q000209:etiology; D011183:Postoperative Complications; D012008:Recurrence; D013396:Suction / Q000009:adverse effects / Q000295:instrumentation
chemical_list: D000871:Anthelmintics