title: A custom-made distraction device for experimental mandibular distraction osteogenesis.
abstract: Distraction osteogenesis has recently become popular in craniofacial reconstruction, after it was first described for long bones. Despite the widespread clinical use of this technique, currently, lack of an ideal experimental model for small animals hampers investigations focused on its molecular basis, which warrants further elucidation. The authors developed a new device for distraction of the rat mandible and, to asses its effectiveness, practiced on 30 animals assigned to either an acute 3-mm distraction group (n = 7) or a gradual distraction group (0.25 mm twice a day for 6 days; n = 23). The authors applied the devices to a localization that allowed them to perform the ostomies posterior to the molar teeth. Because of a U-shaped plate that the authors used for posterior pin fixation, their device maintained its stability until the end of the study, despite the delicate anatomy of the bone at the posterior part of the mandible. Additionally, the authors described a practical and easy method of transient mandibular stabilization method that facilitates the manipulations while the mouth is open for safer airway control during surgery. This new nutrition technique with enteral feeding solution solved the problem of progressive weight loss after surgery. Application of the device was easy and practical, without demanding complex manipulations. The authors did not observe any device dislodgement or a high rate of accidental fractures during the manipulations. They demonstrated that the device works properly and is able to create ossified regenerate bones that fill the entire distraction gap, which can be used for various investigations during distraction osteogenesis.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Gülhane Military Medical Academy, Etlik, Ankara, Turkey. muhieski@yahoo.com
authors.forename: Muhitdin
authors.initials: M
authors.lastname: Eski
authors.forename: Mustafa
authors.initials: M
authors.lastname: Nisanci
authors.forename: Yakup
authors.initials: Y
authors.lastname: Cil
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sengezer
authors.forename: Ayhan
authors.initials: A
authors.lastname: Ozcan
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D004867:Equipment Design; D008297:Male; D008334:Mandible / Q000601:surgery*; D019186:Mandibular Advancement / Q000295:instrumentation*; D019857:Osteogenesis, Distraction / Q000295:instrumentation*; D051381:Rats; D017207:Rats, Sprague-Dawley