Dendritic-cell trafficking to lymph nodes through lymphatic vessels.
Antigen-presenting dendritic cells often acquire foreign antigens in peripheral tissues such as the skin. Optimal encounter with naive T cells for the presentation of these antigens requires that the dendritic cells migrate to draining lymph nodes through lymphatic vessels. In this article, we review important aspects of what is known about dendritic-cell trafficking into and through lymphatic vessels to lymph nodes. We present these findings in the context of information about lymphatic-vessel biology. Gaining a better understanding of the crosstalk between dendritic cells and lymphatic vessels during the migration of dendritic cells to lymph nodes is essential for future advances in manipulating dendritic-cell migration as a means to fine-tune immune responses in clinical settings.
Randolph
Gwendalyn J
GJ
Department of Gene and Cell Medicine, Icahn Research Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1496, New York, New York 10029, USA. gwendalyn.randolph@mssm.edu
Angeli
Veronique
V
Swartz
Melody A
MA
D000818:Animals; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D002633:Chemotaxis / Q000187:drug effects; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D042601:Lymphatic Vessels / Q000166:cytology / Q000276:immunology*
D018925:Chemokines; D007155:Immunologic Factors