High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users.
Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3 pg/ml versus 1352.6 pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.
Kim
Dai-Jin
DJ
Department of Psychiatry, College of Medicine, Korea University Ansan Hospital, Kyunggi Province, Seoul, Korea.
Roh
Sungwon
S
Kim
Yujung
Y
Yoon
Su-Jung
SJ
Lee
Hae-Kook
HK
Han
Chang-Su
CS
Kim
Yong-Ku
YK
D000328:Adult; D019969:Amphetamine-Related Disorders / Q000097:blood*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D008875:Middle Aged
D019208:Brain-Derived Neurotrophic Factor; D000697:Central Nervous System Stimulants; D008694:Methamphetamine