Randomized controlled trial of vaginal misoprostol versus vaginal misoprostol and isosorbide dinitrate for termination of pregnancy at 13-29 weeks.
When compared to the use of 12 hourly 200 microg vaginal misoprostol on its own, the addition of a single dose of 5 mg did not significantly increase the abortion or delivery rate in pregnancy termination at 13-29 weeks gestation. All patients were given intravenous syntocinon at 30 mU/min from the first dose of misoprostol onwards.
Hidar
Samir
S
Department of Obstetrics and Gynaecology, Farhat Hached University Teaching Hospital, 4002, Sousse, Tunisia. hidar.samir@gnet.tn
Bouddebous
Mohamed
M
Chaïeb
Anouar
A
Jerbi
Mehdi
M
Bibi
Mohamed
M
Khaïri
Hédi
H
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced; D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D016896:Treatment Outcome
D000020:Abortifacient Agents, Nonsteroidal; D020030:Nitric Oxide Donors; D016595:Misoprostol; D007548:Isosorbide Dinitrate