3-(2-Aminoethyl)pyridine analogs as alpha4beta2 nicotinic cholinergic receptor ligands.
An examination of several 3-(2-aminoethyl)pyridine analogs suggests that they likely orient at alpha4beta2 nicotinic cholinergic receptors in a different fashion than their correspondingly substituted nicotine analogs.
Dukat
Małgorzata
M
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
Ramunno
Anna
A
Banzi
Rita
R
Damaj
M Imad
MI
Martin
Billy
B
Glennon
Richard A
RA
D003460:Crystallization; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009538:Nicotine / Q000031:analogs & derivatives / Q000378:metabolism; D011485:Protein Binding; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000737:chemistry* / Q000378:metabolism; D012997:Solvents; D013329:Structure-Activity Relationship
D008024:Ligands; D011725:Pyridines; D011978:Receptors, Nicotinic; D012997:Solvents; C403531:nicotinic receptor alpha4beta2; D009538:Nicotine