title: Itching for progress.
abstract: The study of itch remains a neglected field, with a number of barriers limiting satisfactory therapy in the majority of instances. We review recent advances, focusing on the identification of the neural pathways, distinct from pain, that signal itch; methods to measure itch as scratch in humans; and the identification of a role for H4 receptors in mediating itch (in the mouse).
authors.affiliation: Dermatology, University of Edinburgh, Edinburgh, UK. johnathan.rees@ed.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Rees
authors.forename: C S
authors.initials: CS
authors.lastname: Murray
mesh_terms: D000818:Animals; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009434:Neural Pathways / Q000503:physiopathology; D011537:Pruritus / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D011968:Receptors, Histamine / Q000502:physiology
chemical_list: D006633:Histamine Antagonists; D011968:Receptors, Histamine