title: [The expression of ki-67, topoIIalpha in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the expression of ki-67 and topo II alpha in laryngeal squamous cell carcinoma, and the relationship between its intensity and the histological grade clinical stage and lymphoma metastasis.
  
  
  METHODS
  The levels of ki-67 and topo II alpha in larynx were measured by immunohistochemical method.
  
  
  RESULTS
  The positive rate of ki-67 and topo II alpha in laryngeal squamous cell carcinoma were 43.86% and 45.74%, respectively, and that in the control group were 5.66% and 5.98%, respectively. And significant difference was found between the two groups (P < 0.01). The intensity of ki-67 and topo II alpha expression correlated with histological grade. topo II alpha/ki-67 has a relationship to lymphoma metastasis.
  
  
  CONCLUSIONS
  The intensity of ki-67 and topo II alpha expression can evaluate the histological grade of carcinoma. topo II alpha/ki-67 is an indicator of prognosis of Laryngeal Squamous Cell carcinoma.
authors.affiliation: Department of Otorhinolaryngology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430022, China. dg2003wh@163.com
authors.forename: Gang
authors.initials: G
authors.lastname: Deng
authors.forename: Chengzhang
authors.initials: C
authors.lastname: Yang
authors.forename: Wangyan
authors.initials: W
authors.lastname: Chen
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D004250:DNA Topoisomerases, Type II / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D004268:DNA-Binding Proteins; D019394:Ki-67 Antigen; D004250:DNA Topoisomerases, Type II