title: Insertion/deletion polymorphism of the angiotensin converting enzyme gene in coronary artery disease in southern Turkey.
abstract: Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Three hundred and seven patients (187 males and 120 females, aged between 35-80, mean 54.3 +/-9.8 years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %). However, in patients with CAD the frequency of II genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95 % CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.
authors.affiliation: Cukurova University, School of Medicine, Department of Cardiology, 01330 Adana, Turkey. kanarya@cu.edu.tr
authors.forename: Esmeray
authors.initials: E
authors.lastname: Acarturk
authors.forename: Gulen
authors.initials: G
authors.lastname: Attila
authors.forename: Abdi
authors.initials: A
authors.lastname: Bozkurt
authors.forename: Onur
authors.initials: O
authors.lastname: Akpinar
authors.forename: Selcuk
authors.initials: S
authors.lastname: Matyar
authors.forename: Gulsah
authors.initials: G
authors.lastname: Seydaoglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D007703:Peptidyl-Dipeptidase A