[Effect of geniposide on serum IL-1beta and TNF-alpha of rheumatoid arthritis rats].
OBJECTIVE
To study the effect of geniposide on serum IL-1beta and TNF-alpha levels of rheumatoid arthritis rats, as well as the mechanism of this drug.


METHODS
To establish an experimental rat model of type II collagen-induced arthritic (CIA). The inhibitory effects on paw edema were observed, and serum IL-1beta and TNF-alpha levels were determined in experimental rats.


RESULTS
Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1beta and TNF-alpha were significantly decreased by geniposide at high dose or medium dose (P < 0.01).


CONCLUSIONS
Geniposide can lower serum IL-1beta and TNF-alpha levels in rheumatoid arthritis rats. The effect may be close related to inhibitory development of rheumatoid arthritis by the agent.
Zhu
Jiang
J
Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China.
Gao
Xin
X
Xie
Wen-li
WL
Jin
Yu-zhang
YZ
Sun
Wen-jun
WJ
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D024043:Collagen Type II; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D032062:Gardenia / Q000737:chemistry; D006614:Hindlimb / Q000473:pathology; D007375:Interleukin-1 / Q000097:blood*; D039823:Iridoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011714:Pyrans / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D024043:Collagen Type II; D007375:Interleukin-1; D039823:Iridoids; D011714:Pyrans; D014409:Tumor Necrosis Factor-alpha; C007835:geniposide