title: [Effects of orthodontic force on tumor necrosis factor alpha protein expression in the inflammatory periodontal tissues].
abstract: OBJECTIVE
  To explore the combined effects of orthodontic force and inflammation on the remodelling of periodontal tissues.
  
  
  METHODS
  The upper first molars underwent mesial orthodontic force on 48 rats suffering experimental periodontitis and 48 rats injected lipopolysaccharide, respectively.
  
  
  RESULTS
  The TNF-alpha protein expression in the compressed periodontal tissues fluctuated during 0, 2, 12 hours and 2, 7, 14 days stages, the OD value got to the peak in the compressed periodontal tissues in 2 days.
  
  
  CONCLUSIONS
  The mechanical remodelling effects were hindered due to the circumstance of acute or chronic inflammation. The research suggests that the orthodontic treatment to adult patients with periodontal inflammation should be taken carefully.
authors.affiliation: Dental Department, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Xiao
authors.forename: Yang-Xi
authors.initials: YX
authors.lastname: Chen
authors.forename: Ding
authors.initials: D
authors.lastname: Bai
authors.forename: Jing-Ju
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Pei-Jia
authors.initials: PJ
authors.lastname: Duan
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D008963:Molar; D010518:Periodontitis; D051381:Rats; D013314:Stress, Mechanical; D014409:Tumor Necrosis Factor-alpha
chemical_list: D014409:Tumor Necrosis Factor-alpha