[Expression and clinical significance of nm23-H1, Fas and FasL in colorectal carcinoma tissues].
OBJECTIVE
To investigate the expression and clinical significance of nm23-H1, Fas and FasL in colorectal carcinoma tissues.


METHODS
The expression levels of nm23-H1, Fas and FasL in 48 cases of colorectal carcinoma tissues and 15 cases of normal colorectal tissues were determined by SP immunohistochemical staining.


RESULTS
Positive expression rates of nm23-H1, Fas and FasL in colorectal carcinoma were (25.0 +/- 2.6)%, (41.7 +/- 2.7) and (77.1 +/- 2.7)% respectively; the positive expression rates of nm23-H1 and Fas were lower than that in the normal colorectal tissues (P<0.01); the FasL expression rate in colorectal carcinoma tissues was higher than that in the normal colorectal tissues (P<0.01); the lower expression of nm23-H1 and Fas, and the higher expression of FasL in colorectal carcinoma were correlated with the type of carcinoma histology, lymph node metastasis, Dukes' stage and prognosis (P<0.01).


CONCLUSIONS
These results suggest that the lower expression of nm23-H1 and Fas and higher expression of FasL may be used as a good indicator in evaluating lymph node metastasis and prognosis.
Lin
Man-hua
MH
Institute of Laboratory Medicine, Guangdong Medical College, Zhanjiang 524023, China.
Yao
Yun-hong
YH
Yu
Jian-hua
JH
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis* / Q000235:genetics; D048069:Tumor Necrosis Factors / Q000096:biosynthesis* / Q000235:genetics; D019014:fas Receptor
C491901:FAS protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D054778:NM23 Nucleoside Diphosphate Kinases; D018124:Receptors, Tumor Necrosis Factor; D048069:Tumor Necrosis Factors; D019014:fas Receptor; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase