title: Palladium-assisted multicomponent synthesis of 2-aryl-4-aminoquinolines and 2-aryl-4-amino[1,8]naphthyridines.
abstract: A palladium-mediated multicomponent domino reaction leading to 2-aryl-4-amino-quinolines and 2-aryl-4-amino[1,8]naphthyridines is reported. The scope of the reaction was examined using carbon monoxide, two 2-ethynyl-arylamines, four aryl iodides, and 10 primary amines as substrates. The selection of the appropriate catalytic system was achieved testing several palladium/phosphine systems and overrides previously reported drawbacks associated with the use of primary amines in related reactions. Moreover several features concerning the role of both palladium [(0) and (II)] and phosphines are reported.
authors.affiliation: Istituto di Chimica Organica Alessandro Marchesini, Facoltà di Farmacia, Università degli Studi di Milano, Via Venezian, 21, 20133 Milano, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Abbiati
authors.forename: Antonio
authors.initials: A
authors.lastname: Arcadi
authors.forename: Valentina
authors.initials: V
authors.lastname: Canevari
authors.forename: Luca
authors.initials: L
authors.lastname: Capezzuto
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Rossi