title: Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice.
abstract: In mice, vancomycin and linezolid treatment disrupted the anaerobic intestinal microflora, based on denaturing gradient gel electrophoresis analysis, and promoted colonization by Klebsiella pneumoniae and vancomycin-resistant enterococci. However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen.
authors.affiliation: Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, Ohio 44106, USA.
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Pultz
authors.forename: Usha
authors.initials: U
authors.lastname: Stiefel
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000254:growth & development; D017576:Daptomycin / Q000008:administration & dosage / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D000069349:Linezolid; D051379:Mice; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D014640:Vancomycin / Q000008:administration & dosage / Q000494:pharmacology*; D020713:Vancomycin Resistance; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D001618:beta-Lactamases; D000069349:Linezolid; D017576:Daptomycin