title: Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese.
abstract: BACKGROUND
  Low-density lipoprotein receptor-related protein 1 (LRP1) and alpha-2-macroglobulin (A2M) are two plausible candidate genes for Alzheimer disease (AD) based on their important biological function and positional information. To date, numerous studies have investigated their possible association with AD but the results are controversial.
  
  
  METHODS
  To investigate the potential genetic contribution of the two genes in the Han Chinese population, we performed a case-control association study using 10 polymorphisms (4 in LRP1 and 6 in A2M) that span approximately the whole corresponding gene.
  
  
  RESULTS
  Comparison of allele, genotype, and haplotype frequencies for polymorphisms in A2M revealed no significant differences between patients and control subjects. For the LRP1 gene, however, we found an overrepresentation of the CTCG haplotype in the control group (p = .002). The difference was still of statistical significance in the apolipoprotein E (APOE) epsilon 4 negative subjects (p(CTCG) = .003). Multiple logistic regression analysis did not show any evidence of synergism between A2M, LRP1, and APOE.
  
  
  CONCLUSIONS
  Our results indicate that the CTCG haplotype of LRP1 may reduce the risk of late-onset AD, but A2M is not associated with this disease in the Han Chinese population.
authors.affiliation: Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Bio-X Center, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Bian
authors.forename: Jian Dong
authors.initials: JD
authors.lastname: Yang
authors.forename: Ting Wei
authors.initials: TW
authors.lastname: Guo
authors.forename: Yun
authors.initials: Y
authors.lastname: Duan
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Guo Yin
authors.initials: GY
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D005819:Genetic Markers; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D000511:alpha-Macroglobulins; D004247:DNA