title: One click, two clicks: the past shapes the future in auditory cortex.
abstract: What are the synaptic and cellular mechanisms by which stimulus context shapes cortical responses? In this issue of Neuron, Wehr and Zador describe intracellular recordings of responses to click pairs in rat primary auditory cortex (A1) and offer new insights into the successive roles of inhibition and synaptic depression in suppressing responses to the second click in many A1 neurons.
authors.affiliation: Center for Acoustic and Auditory Research, The Institute for Systems Research, University of Maryland, College Park 20742, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fritz
authors.forename: Shihab
authors.initials: S
authors.lastname: Shamma
authors.forename: Mounya
authors.initials: M
authors.lastname: Elhilali
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology* / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats