title: Successful treatment of Aspergillus prosthetic valve endocarditis with oral voriconazole.
abstract: Aspergillus endocarditis is very difficult to cure, even with aggressive surgical debridement and antifungal therapy. Patients with embolic involvement of the central nervous system have an extremely poor prognosis. We describe a patient with prosthetic valve endocarditis due to Aspergillus fumigatus who developed emboli in the brain, eye, and lower extremities. With aggressive surgical debridement of involved sites, aortic valve and root replacement, and long-term therapy with oral voriconazole, he remains without any evidence of infection 2 years later.
authors.affiliation: Hospital of The University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Reis
authors.forename: Todd D
authors.initials: TD
authors.lastname: Barton
authors.forename: Alberto
authors.initials: A
authors.lastname: Pochettino
authors.forename: Omaida
authors.initials: O
authors.lastname: Velazquez
authors.forename: Michael
authors.initials: M
authors.lastname: McGarvey
authors.forename: Bonnie
authors.initials: B
authors.lastname: Milas
authors.forename: Annette
authors.initials: A
authors.lastname: Reboli
authors.forename: Mindy G
authors.initials: MG
authors.lastname: Schuster
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy*; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole