[Suppression of glial fibrillary acidic protein expression in astrocytes of the superficial glial limiting membrane after traumatic subarachnoid hemorrhage].
Although typical astrocytic reaction to brain injury is accompanied by an increase of glial fibrillary acidic protein (GFAP) expression, to what degree this reaction is universal remains to be elucidated. The aim of the present study was to investigate the reaction of superficial glial limiting membrane of human brain to traumatic subarachnoid hemorrhage. Using light microscopy and immunocytochemistry, it was found that a suppresion of GFAP expression in astrocytes of superficial glial limiting membrane occurred up to 3 days following the brain trauma. The data obtained suggest the existence of regional peculiarities of astrocytic reaction.
Korzhevskiĭ
D E
DE
Nikoleĭshvili
M G
MG
Otellin
V A
VA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001253:Astrocytes / Q000378:metabolism*; D001930:Brain Injuries / Q000150:complications*; D015536:Down-Regulation; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008566:Membranes / Q000378:metabolism; D008875:Middle Aged; D009457:Neuroglia / Q000378:metabolism; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000378:metabolism*
D005904:Glial Fibrillary Acidic Protein