title: Analysis of captan on nitrile glove surfaces using a portable attenuated total reflection fourier transform infrared spectrometer.
abstract: This study developed a method to produce uniform captan surface films on a disposable nitrile glove for quantitation with a portable attenuated total reflection Fourier transform infrared (ATR-FTIR) spectrometer. A permeation test was performed using aqueous captan formulation. Uniform captan surface films were produced using solvent casting with 2-propanol and a 25 mm filter holder connected to a vacuum manifold to control solvent evaporation. The coefficient of variation of the reflectance at 1735 +/- 5 cm(-1) was minimized by selection of the optimum solvent volume, airflow rate, and evaporation time. At room temperature, the lower to upper quantifiable limits were 0.31-20.7 microg/cm2 (r = 0.9967; p < or = 0.05) for the outer glove surface and 0.55-17.5 microg/cm2 (r = 0.9409; p < or = 0.05) for the inner surface. Relative humidity and temperature did not affect the uncoated gloves at the wavelength of captan analysis. Glove screening using ATR-FTIR was necessary as a control for between-glove variation. Captan permeation, after 8 hours exposure to an aqueous concentration of 217 mg/mL of Captan 50-WP, was detected at 0.8 +/- 0.3 microg/cm2 on the inner glove surface. ATR-FTIR can detect captan permeation and can determine the protectiveness of this glove in the field.
authors.affiliation: Department of Environmental Health Sciences, and UCLA Center for Occupational and Environmental Health, School of Public Health, 650 Charles Young Jr. Drive South, Los Angeles, California 90095-1772, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Phalen
authors.forename: Shane S
authors.initials: SS
authors.lastname: Que Hee
mesh_terms: D000465:Algorithms; D002215:Captan / Q000032:analysis* / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000032:analysis* / Q000737:chemistry; D019544:Equipment Failure Analysis / Q000379:methods*; D017575:Gloves, Protective; D008422:Materials Testing; D009570:Nitriles / Q000032:analysis* / Q000737:chemistry; D010539:Permeability; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D020099:Coated Materials, Biocompatible; D009570:Nitriles; D002215:Captan