Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients.
Postprandial hypertriglyceridemia is considered as a risk factor for cardiovascular disease in Type 2 diabetes. However, little is known about the underlying mechanisms. Since the recently discovered apolipoprotein (apo) AV was identified as a modulator of triglyceride (TG) metabolism, the aim of the study was to determine the postprandial apoAV profile of Type 2 diabetic patients. We compared data from 11 patients with Type 2 diabetes mellitus to that of 12 non-diabetic normolipidemic subjects following the ingestion of a lipid-rich cream. Postprandial apoAV was elevated in diabetic patients but no correlation was observed either with plasma TG concentration or with the intensity of lipoprotein lipase-dependent lipolysis. These data obtained in human subjects suggest that plasma apoAV concentration does not play an acute or a direct role in the regulation of plasma TG in the postprandial state.
Pruneta-Deloche
Valérie
V
UMR 585 INSERM/INSA, Physiopathologie des Lipides et Membranes, Villeurbanne, France. valerie.pruneta-deloche@insa-lyon.fr
Ponsin
Gabriel
G
Groisne
Laure
L
Fruchart-Najib
Jamila
J
Lagarde
Michel
M
Moulin
Philippe
P
D000328:Adult; D000072040:Apolipoprotein A-V; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008066:Lipolysis / Q000502:physiology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D014280:Triglycerides / Q000097:blood*
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001053:Apolipoproteins; D001054:Apolipoproteins A; D014280:Triglycerides