title: [Study on chemical constituents in rhizome of Pinellia ternata].
abstract: OBJECTIVE
  To study the chemical constituents in rhizome of Pinellia ternata.
  
  
  METHODS
  The constituents were isolated by silica-gel and Sephadex LH-20 chromatography. The structures were identified by spectroscopic analysis including 2D NMR techniques.
  
  
  RESULTS
  Six compounds were obtained and identified as stigmast-4-en-3-one(I), cycloartenol(II), 5alpha,8alpha-epidioxyergosta-6,22-dien-3-ol(III), beta-sitosterol-3-O-beta-D-glucoside-6'-eicosanate(IV), alpha-monpalmitin(V), beta-sitosterol(VI). The bioactive assay indicated that: compound III was active against the human tumor cell lines HCT-8, Bel-7402, BGC-823, A549, A2780.
  
  
  CONCLUSIONS
  Compounds I-IV were isolated from Pinellia ternata for the first time, compound II was the first triterpene isolated from this genus. Compound III may be one of the antitumor constituents of P. ternata.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Su-juan
authors.initials: SJ
authors.lastname: Wang
authors.forename: Yong-chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Jian-gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification*; D030021:Pinellia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D013265:Stigmasterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes
chemical_list: C503471:5alpha,8alpha-epidioxyergosta-6,22-dien-3-beta-ol; D000972:Antineoplastic Agents, Phytogenic; D010840:Phytosterols; D014315:Triterpenes; C488470:stigmast-4-en-3-one; D013265:Stigmasterol; C100089:cycloartenol; D004875:Ergosterol