Antimitotic properties of pterocarpans isolated from Platymiscium floribundum on sea urchin eggs.
This study reports the antimitotic effects on sea urchin eggs of five known pterocarpans: (+)-3,10-dihydroxy-9-methoxypterocarpan, (+)-3,9-dimethoxypterocarpan [(+)-homopterocarpin], (+)-2,3,9-trimethoxypterocarpan, (+)-3,4-dihydroxy-9-methoxypterocarpan [(+)-vesticarpan] and (+)-3-hydroxy-9-methoxypterocarpan [(+)-medicarpin], isolated from the trunk of Platymiscium floribundum, a native tree from Brazil. All tested compounds showed strong activity in this assay, with 2,3,9-trimethoxypterocarpan being the most active (log IC50 of -8.10 +/- 0.02; -7.91 +/- 0.01; -7.97 +/- 0.02 M for first and third cleavages, and blastulae stages, respectively). These data suggest that the 2-methoxy substituent can be an important pharmacophoric unit.
Militão
Gardênia Carmen
GC
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Ceará, Brasil.
Jimenez
Paula Christine
PC
Wilke
Diego Veras
DV
Pessoa
Cláudia
C
Falcão
Maria José
MJ
Sousa Lima
Mary Anne
MA
Silveira
Edilberto Rocha
ER
de Moraes
Manoel Odorico
MO
Costa-Lotufo
Letícia Veras
LV
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D020128:Inhibitory Concentration 50; D008938:Mitosis / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012617:Sea Urchins; D014197:Trees; D014934:Wood
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts