title: Optical coherence tomography characteristics of choroidal metastasis.
abstract: OBJECTIVE
  To report 4 patients (7 eyes) with choroidal metastasis (primary: breast [2], lung [1], and unknown [1]) visualized with optical coherence tomography (OCT).
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Four patients (7 eyes) with choroidal metastasis participated in the study.
  
  
  METHODS
  Clinical examination, ultrasonography, fluorescein angiography, and OCT were performed in all cases.
  
  
  METHODS
  Optical coherence tomography characteristics.
  
  
  RESULTS
  Three patients suffered a gradual onset of blurred vision in both eyes. The fourth presented a unilateral decrease in visual acuity. Bilateral choroidal lesions with various degrees of exudative retinal detachment (RD) were present in 3 of our 4 patients, and there was 1 case of a unilateral unifocal choroidal lesion. Optical coherence tomography revealed anterior displacement of the photoreceptor layer by subretinal fluid (hyporeflective space) overlying a hyperreflective thickened retinal pigment epithelium-choriocapillaris complex. Subretinal deposits with several degrees of hyperreflectivity were seen, as well as loss of normal retinal architecture with intraretinal splitting, identified as regions of low reflectance within the neurosensory retina. After chemotherapy, OCT demonstrated improvement of the serous RD and reduction of the lesion's size with recovery of the normal retinal architecture.
  
  
  CONCLUSIONS
  Optical coherence tomography in patients with choroidal metastasis allows evaluation of secondary retinal-retinal pigment epithelial changes. In addition, the technique is useful in the follow-up of lesions after treatment. However, some limitations result from the choroidal location of the metastasis. Further studies with clinicopathological correlation are needed to confirm our observations.
authors.affiliation: Retina and Vitreous Service, Clínica Oftalmológica Centro Caracas, Caracas, Venezuela. areval1@telcel.net.ve
authors.forename: J Fernando
authors.initials: JF
authors.lastname: Arevalo
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Fernandez
authors.forename: Reinaldo A
authors.initials: RA
authors.lastname: Garcia
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000556:secondary*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D012160:Retina / Q000473:pathology; D012163:Retinal Detachment / Q000175:diagnosis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence