title: Squamous cell metaplasia of the nasopharyngeal epithelium and its association with adult-onset otitis media with effusion.
abstract: CONCLUSIONS
  The common association between adult-onset otitis media with effusion (AO-OME) and squamous cell metaplasia (SCM) of the epithelium of Rosenmüller's fossa, which is near the Eustachian tube orifice, implies the predictive role of metaplasia, which probably compromises the drainage function of the middle ear.
  
  
  OBJECTIVE
  To determine the effects of nasopharyngeal epithelial changes (SCM) on AO-OME. AO-OME is a multifactorial and insidious disease that may necessitate detailed investigation, i.e. biopsy of the nasopharynx, because of possible underlying nasopharyngeal malignancy.
  
  
  METHODS
  Fifty-two patients with AO-OME (study group) and 29 with a unilateral neck mass in the posterior triangle without AO-OME (control group) were enrolled. Nasopharyngeal biopsies taken from all subjects were evaluated with regard to surface epithelial changes of the nasopharynx.
  
  
  RESULTS
  Nasopharyngeal biopsies revealed SCM in 34/52 patients (65%) in the study group and 9/29 (31%) in the control group (p<0.05). During the follow-up period, recurrence of effusion occurred in 56% of the group with SCM and 22% of the group without it.
authors.affiliation: Department of Ear Nose and Throat-Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Doğru
authors.forename: Hasan
authors.initials: H
authors.lastname: Yasan
authors.forename: Ozden
authors.initials: O
authors.lastname: Candir
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tüz
authors.forename: Metin
authors.initials: M
authors.lastname: Ciriş
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D004724:Endoscopy; D004847:Epithelial Cells / Q000473:pathology; D005064:Eustachian Tube / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008199:Lymphadenitis / Q000150:complications; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D008876:Middle Ear Ventilation; D009296:Nasal Cavity / Q000473:pathology; D009305:Nasopharynx / Q000473:pathology*; D009333:Neck; D010034:Otitis Media with Effusion / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D014388:Tuberculosis, Lymph Node / Q000150:complications