title: [Modulating effect of amino acids on cerebella of rats of various age in organotypic tissue culture].
abstract: There was studied in cerebella organotypic tissue culture the effect of effective concentrations (0.05 ng/ml) of 20 amino acids on the development of of proliferative activity in peripheral fields of explants of rats of various age: 3 days and 18 months old. The amino acids glycine, asparagine, lysine, arginine, proline, glutamine acid, cysteine, valine and isoleucine acid are active, inducing a more intensive growth zone in explants in 3-day old rats, as compared to control. The inhibitory effect was not observed. In the cerebella explant of old rats there was observed the inhibitory effect of 7 amino acids due to the apoptosis. This effect might be take in account by the synthesis of bioregulator peptides, contained these amino acids.
authors.forename: A V
authors.initials: AV
authors.lastname: Komashnia
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: V A
authors.initials: VA
authors.lastname: Pennijainen
authors.forename: A I
authors.initials: AI
authors.lastname: Aniskina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Konovalova
mesh_terms: D000367:Age Factors; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids