title: Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia.
abstract: Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARbeta, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARbeta was more frequent in adult ALL than that in childhood ALL (p=0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL (p=0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL (p=0.01).
authors.affiliation: Department of Medicine, Kochi Medical School, Okoh-cho, Nankoku, Kochi 783-8505, Japan.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Seisho
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Wolf K
authors.initials: WK
authors.lastname: Hofmann
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ikezoe
authors.forename: Jacques J M
authors.initials: JJ
authors.lastname: van Dongen
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szczepański
authors.forename: Claus R
authors.initials: CR
authors.lastname: Bartram
authors.forename: Norihide
authors.initials: N
authors.lastname: Yoshino
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Taguchi
authors.forename: H Phillip
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018899:CpG Islands; D019175:DNA Methylation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins