title: Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis.
abstract: Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies. The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage. In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality. Fluorescence in situ hybridization revealed tetrasomy 8 and trisomy 8 concurrently in all but one of the bone marrow samples. The clonal relationship between trisomy 8 and tetrasomy 8 in these cases remains to be clarified. Patients with tetrasomy 8 have a poor prognosis, and only 1 out of 33 patients was free of disease 3 years after autologous bone marrow transplantation. Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8.
authors.affiliation: Second Department of Internal Medicine, Propaedeutic, Haematology Unit, University of Athens, Attikon Hospital, 1 Rimini Street, Haidari 124 62, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsirigotis
authors.forename: Sotirios
authors.initials: S
authors.lastname: Papageorgiou
authors.forename: Danai
authors.initials: D
authors.lastname: Abatzis
authors.forename: Sofia
authors.initials: S
authors.lastname: Athanatou
authors.forename: Constantinos
authors.initials: C
authors.lastname: Girkas
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Pappa
authors.forename: Constantinos
authors.initials: C
authors.lastname: Pangalos
authors.forename: Efstathios
authors.initials: E
authors.lastname: Papageorgiou
authors.forename: John
authors.initials: J
authors.lastname: Dervenoulas
authors.forename: Sotirios
authors.initials: S
authors.lastname: Raptis
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D011379:Prognosis