Electron microscopic characterization of gels formed by blood cells of leukemia patients at hypertonicity.
At hypertonicity some blood cells of patients suffering chronic leukemia can form gel like layers around themselves. These gels, which are sensitive to hyaluronidase, but not to trypsin are investigated by electron microscopy. The study revealed that the gels comprise a network of nanoparticles, which have diameters between 50 and 150 nm, are regularly ordered and linked to each other.
Golovanov
Michael V
MV
Oncology Center, 24 Kashirskoye Shose, 115478 Moscow, Russia.
Bauer
Johann
J
D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D004912:Erythrocytes / Q000502:physiology* / Q000648:ultrastructure; D005782:Gels; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood* / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000648:ultrastructure; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*
D005782:Gels; D012462:Saline Solution, Hypertonic