[Renal aging].
Frequently underestimated, the deterioration of the renal function characteristic of the aging has very prominent clinical consequences. In the present article some aspects of the cellular and molecular biology of this process are analysed. The critical role of the oxidative stress and of TGFbeta are underlined. Determinant genetic factors are also mentioned. Such a knowledge can contribute to develop therapeutical strategies to prevent the decline of the.renal function that happens with the aging.
Pérez Rivero
G
G
Sección de Nefrología y Unidad de Investigación, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Madrid.
Torres Ruiz
M P
MP
Serrano
I
I
Bouarich
H
H
Rodríguez Puyol
D
D
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D015152:Blotting, Northern; D005109:Extracellular Matrix / Q000378:metabolism; D005609:Free Radicals; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D007672:Kidney Cortex / Q000378:metabolism / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics
D000975:Antioxidants; D005609:Free Radicals; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D013482:Superoxide Dismutase