title: [Micrometastases in patients with colorectal cancer: markers for metastatic potential or proofs for residual disease].
abstract: It is know that bone marrow micrometastases are an indicator of poor prognosis in patients with epithelial tumors. At the same time little is known if they reflect minimal residual disease or cells distribution and marked metastatic potential. We aimed to perform a clinical study, which though with little gathered clinical material has a direction--investigation of bone marrow in patients with colorectal cancer by the time of surgery, carefully rendering an account of staging and performing curative resection. In intraoperatively done bone marrow biopsy with following investigation for cytoceratin 19 positive cells we found ol presence of metastatic cells in some the studied patients. Finding micrometastases in patients with colorectal cancer is a marker for more agressive course of the disease and for the need to change some of recent methods of treatment.
authors.forename: I
authors.initials: I
authors.lastname: Iovchev
authors.forename: D
authors.initials: D
authors.lastname: Trifonov
authors.forename: A
authors.initials: A
authors.lastname: Popkharitov
authors.forename: F
authors.initials: F
authors.lastname: Khadzhipetkov
authors.forename: S
authors.initials: S
authors.lastname: Nikolov
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D001856:Bone Marrow Examination; D019046:Bone Marrow Neoplasms / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007633:Keratins / Q000032:analysis; D009362:Neoplasm Metastasis; D018365:Neoplasm, Residual
chemical_list: D014408:Biomarkers, Tumor; D007633:Keratins