title: Reward and anxiety in genetic animal models of childhood depression.
abstract: One of the most important criteria for major depressive disorder in adults and in children and adolescents as well, is the loss of interest in or pleasure from typically enjoyable experiences or activities: anhedonia. Anxiety is frequently co-morbid with depression. We examined reward and anxiety in genetic animal models of childhood depression. Two different "depressed" lines were studied: the Flinders Sensitive Line (FSL) and their controls, Sprague-Dawley (SD) rats and the Wistar Kyoto (WKY) line and their controls, Wistar rats. Recently, we found that prepubertal rats (about 35 days old) from these lines exhibited increased immobility in the swim test, and abnormal social play observed after 24-h isolation. We hypothesized that FSL and WKY prepubertal rats will further show anhedonia in two different behavioral assays: the conditioned place preference test (CPP), examining the rewarding aspect of social interaction and the saccharin preference test. Behavior in the open field paradigm and freezing behavior in the CPP apparatus were also used as measures of anxiety. WKY, but not FSL prepubertal rats, consumed less of the saccharin solution compared to their control line. FSL, and WKY prepubertal rats found social interaction to be rewarding to a similar extent as their control lines, in the CPP test. Only the WKY rats showed anxiety in behavior in the open field and freezing behavior in the CPP paradigm. The results suggest that WKY prepubertal rats are anxious and sensitive to stress-induced anhedonia, while FSL prepubertal rats exhibit none of these symptoms.
authors.affiliation: Interdisciplinary Program in the Brain Sciences, Bar-Ilan University, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Malkesman
authors.forename: Y
authors.initials: Y
authors.lastname: Braw
authors.forename: O
authors.initials: O
authors.lastname: Zagoory-Sharon
authors.forename: O
authors.initials: O
authors.lastname: Golan
authors.forename: Y
authors.initials: Y
authors.lastname: Lavi-Avnon
authors.forename: M
authors.initials: M
authors.lastname: Schroeder
authors.forename: D H
authors.initials: DH
authors.lastname: Overstreet
authors.forename: G
authors.initials: G
authors.lastname: Yadid
authors.forename: A
authors.initials: A
authors.lastname: Weller
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000150:complications* / Q000235:genetics; D002648:Child; D003214:Conditioning, Classical / Q000502:physiology; D003865:Major Depressive Disorder / Q000150:complications* / Q000235:genetics; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000502:physiology; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012201:Reward; D012741:Sexual Maturation; D012919:Social Behavior; D013045:Species Specificity; D013315:Stress, Psychological / Q000150:complications* / Q000235:genetics; D013649:Taste / Q000235:genetics / Q000502:physiology