Itching for progress.
The study of itch remains a neglected field, with a number of barriers limiting satisfactory therapy in the majority of instances. We review recent advances, focusing on the identification of the neural pathways, distinct from pain, that signal itch; methods to measure itch as scratch in humans; and the identification of a role for H4 receptors in mediating itch (in the mouse).
Rees
J
J
Dermatology, University of Edinburgh, Edinburgh, UK. johnathan.rees@ed.ac.uk
Murray
C S
CS
D000818:Animals; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009434:Neural Pathways / Q000503:physiopathology; D011537:Pruritus / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D011968:Receptors, Histamine / Q000502:physiology
D006633:Histamine Antagonists; D011968:Receptors, Histamine