Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.
Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described.
Kuehn
Markus H
MH
Department of Ophthalmology and Visual Sciences, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Fingert
John H
JH
Kwon
Young H
YH
D017209:Apoptosis; D005901:Glaucoma / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012165:Retinal Ganglion Cells / Q000473:pathology*
D018696:Neuroprotective Agents