title: Acylphloroglucinol derivatives from Mahurea palustris.
abstract: Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 microM range.
authors.affiliation: Joint Service Unit No. 2597, National Center for Scientific Research (CNRS)-Pierre Fabre, Sciences and Technologies Institute of Medicine of Toulouse, 31432 Toulouse, France. georges.massiot@pierre-fabre.com
authors.forename: Georges
authors.initials: G
authors.lastname: Massiot
authors.forename: Christophe
authors.initials: C
authors.lastname: Long
authors.forename: Bruno
authors.initials: B
authors.lastname: David
authors.forename: Marie-Jeanne
authors.initials: MJ
authors.lastname: Serrano
authors.forename: Florence
authors.initials: F
authors.lastname: Daubié
authors.forename: Frédéric
authors.initials: F
authors.lastname: Alby
authors.forename: Frédéric
authors.initials: F
authors.lastname: Ausseil
authors.forename: Martine
authors.initials: M
authors.lastname: Knibiehler
authors.forename: Christian
authors.initials: C
authors.lastname: Moretti
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Hoffmann
authors.forename: Christophe
authors.initials: C
authors.lastname: Cazaux
authors.forename: Catherine
authors.initials: C
authors.lastname: Lavaud
mesh_terms: D028084:Clusiaceae / Q000737:chemistry*; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005616:French Guiana; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D010696:Phloroglucinol; D019951:DNA Polymerase beta