Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones.
A novel set of acridinylidene thiazolidinediones and benzylidene thiazolidinediones was synthesized by nucleophilic addition of cyanoacrylates. Some of these compounds were evaluated for their glucose lowering capability and their effects on the triglyceride level in alloxan diabetic mice.
Mourão
R H
RH
Departamento de Antibioticos, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50670-901 Recife, Brasil.
Silva
T G
TG
Soares
A L M
AL
Vieira
E S
ES
Santos
J N
JN
Lima
M C A
MC
Lima
V L M
VL
Galdino
S L
SL
Barbe
J
J
Pitta
I R
IR
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000401:mortality; D004353:Drug Evaluation, Preclinical; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
C507737:3-benzyl-5-acridinylidene-thiazolidine-2,4-dione; C507736:5-benzylidene-3-(4-methyl-benzyl)-thiazolidine-2,4-dione; D000166:Acridines; D001593:Benzyl Compounds; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D014280:Triglycerides; D000077154:Rosiglitazone