title: Role of morphogens in neural crest cell determination.
abstract: The neural crest is a transient, migratory cell population found in all vertebrate embryos that generate a diverse range of cell and tissue derivatives including, but not limited, to the neurons and glia of the peripheral nervous system, smooth muscle, connective tissue, melanocytes, craniofacial cartilage, and bone. Over the past few years, many studies have provided tremendous insights into understanding the mechanisms regulating the induction and migration of neural crest cell development. This review highlights the surprising and perhaps unexpected roles for morphogens in these distinct processes. A comparison of studies performed in several different vertebrates emphasizes the requirement for coordination between multiple signaling pathways in the induction and migration of neural crest cells in the developing embryo.
authors.affiliation: Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA.
authors.forename: Natalie C
authors.initials: NC
authors.lastname: Jones
authors.forename: Paul A
authors.initials: PA
authors.lastname: Trainor
mesh_terms: D000663:Amphibians; D000818:Animals; D001717:Birds; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005399:Fishes; D053823:Hedgehog Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008322:Mammals; D009432:Neural Crest / Q000166:cytology* / Q000254:growth & development*; D012176:Retinoids / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013045:Species Specificity; D015534:Trans-Activators / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012176:Retinoids; D015534:Trans-Activators