title: Of mice and men: the iron age.
abstract: Recently, mutations causing juvenile hemochromatosis have been identified in a novel gene, hemojuvelin (HJV), located on chromosome 1. Mouse models of this disease have now been developed by 2 groups, Huang et al. and Niederkofler et al., through targeted disruption of the Hjv gene (see the related articles beginning on pages 2180 and 2187). These mutant mice will allow further investigation into the role of HJV in the regulation of iron homeostasis, a role that to date remains elusive.
authors.affiliation: Institut Cochin, INSERM 567, CNRS 8104, Université Paris 5, Paris, France. vaulont@cochin.inserm.fr
authors.forename: Sophie
authors.initials: S
authors.lastname: Vaulont
authors.forename: Dan-Qing
authors.initials: DQ
authors.lastname: Lou
authors.forename: Lydie
authors.initials: L
authors.lastname: Viatte
authors.forename: Axel
authors.initials: A
authors.lastname: Kahn
mesh_terms: D000818:Animals; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D004195:Disease Models, Animal; D058851:GPI-Linked Proteins; D006432:Hemochromatosis / Q000235:genetics* / Q000378:metabolism; D000071020:Hemochromatosis Protein; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout
chemical_list: D058851:GPI-Linked Proteins; C481006:HJV protein, human; D000071020:Hemochromatosis Protein; D008565:Membrane Proteins; D007501:Iron