title: Determination of norfloxacin using a terbium-sensitized electrogenerated chemiluminescence method.
abstract: A simple electrogenerated chemiluminescence (ECL) analysis method for the determination of norfloxacin (NFLX) is reported. It is based on ECL produced by Na(2)SO(3), which is sensitized by the Tb-NFLX complex. The relative ECL intensity of the Tb(3+)-NFLX-Na(2)SO(3) system is proportional to the amount of NFLX. The optimized experimental conditions were investigated. The linear range and detection limit for NFLX were 1.0 x 10(-10)-8.0 x 10(-7) mol/L and 2.8 x 10(-11) mol/L, respectively. This method was successfully applied to the determination of NFLX in a capsule. NFLX in urine can be directly detected without pretreatment or separation.
authors.affiliation: Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.
authors.forename: Shi-Lv
authors.initials: SL
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Hui-Chun
authors.initials: HC
authors.lastname: Zhao
authors.forename: Lin-Pei
authors.initials: LP
authors.lastname: Jin
authors.forename: Zhong-Lun
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Yan-Zhen
authors.initials: YZ
authors.lastname: Zheng
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D009643:Norfloxacin / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry; D013725:Terbium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D013431:Sulfates; D013725:Terbium; C012036:sodium sulfate; D009643:Norfloxacin