Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.
Several efficient synthetic routes for 2-, 4-, and 6-aryl-1,2,4-triazine-3,5-diones were developed. Derivatives were synthesized and studied as gonadotropin-releasing hormone antagonists in an effort to understand structure-activity relationships of the monocyclic compounds.
Pontillo
Joseph
J
Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, USA.
Guo
Zhiqiang
Z
Wu
Dongpei
D
Struthers
R Scott
RS
Chen
Chen
C
D006801:Humans; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D011485:Protein Binding; D011966:Receptors, LHRH / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D007659:Ketones; D011966:Receptors, LHRH; D014227:Triazines