Molecular design, chemical synthesis, and evaluation of cytosine-carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA.
The designed cytosine-carbohydrate hybrid molecule selectively recognized and stabilized the bulged duplex DNA possessing the complementary bulged DNA base, guanine, while the nucleotide base itself did not exhibit any such ability. It was also found that the assistance of the carbohydrate to stabilize the interaction between the nucleotide base and the complementally bulge DNA base is very helpful for the selective recognition and stabilization of the single-bulged duplex DNA.
Idutsu
Yusuke
Y
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Sasaki
Ayaka
A
Matsumura
Shuichi
S
Toshima
Kazunobu
K
D020137:Base Pair Mismatch; D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry*; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D006147:Guanine; D007364:Intercalating Agents; D015335:Molecular Probes; D009691:Nucleic Acid Denaturation; D013329:Structure-Activity Relationship; D013696:Temperature
D002241:Carbohydrates; D007364:Intercalating Agents; D015335:Molecular Probes; D006147:Guanine; D003596:Cytosine; D004247:DNA