title: Anticoccidial efficacy of drinking water soluble diclazuril on experimental and field coccidiosis in broiler chickens.
abstract: Prophylactic and curative capacity of water soluble formulation of Diclazuril (Diclosol 1%) and feed additive form (Clinacox, 0.5%) were tested against Eimeria infection in broiler chickens. Such testing was performed both experimentally and in the field. Toltrazuril (Baycox, 2.5%) was used as reference control drug. Water soluble formulation of Diclazuril induced a marked inhibitory effect on the different stages of the parasite life cycle in experimentally infected treated birds especially when applied on the day when blood first appeared in the faeces [fifth day post-infection (d.p.i.)] as well as on the second day of blood dropping (6 d.p.i.). Both tested dosage levels of Diclazuril water soluble formulation in drinking water (5 and 10 ppm) showed the same effect in controlling coccidial infection and reducing the total oocyst numbers, lesion and faecal scores. Moreover, there was no significant difference in the efficacy of water soluble form of Diclazuril and the reference control drug (Toltrazuril, 25 ppm). In addition, testing the water soluble formulation (5 ppm) in naturally infected poultry farm (20,000 birds), showed the same anticoccidial effect observed when using Toltrazuril, as a treatment for coccidiosis. In conclusion, addition of Diclazuril at the dose of 5 ppm in the drinking water of naturally coccidia infected bird induced the same effect as 25 ppm of Toltrazuril as a treatment for coccidiosis in chickens.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. drelbanna3@yahoo.com
authors.forename: H A
authors.initials: HA
authors.lastname: El-Banna
authors.forename: M M
authors.initials: MM
authors.lastname: El-Bahy
authors.forename: H Y
authors.initials: HY
authors.lastname: El-Zorba
authors.forename: M
authors.initials: M
authors.lastname: El-Hady
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000737:chemistry / Q000627:therapeutic use*; D004326:Drinking; D009570:Nitriles / Q000737:chemistry / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000517:prevention & control; D011897:Random Allocation; D012995:Solubility; D016896:Treatment Outcome; D014227:Triazines / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D003049:Coccidiostats; D009570:Nitriles; D014227:Triazines; C057884:diclazuril