Successful recovery of aplastic anemia following orthotopic liver transplantation for non-A-E acute liver failure.
This report describes a teenager who developed aplastic anemia (AA) because of non-A-E acute liver failure (ALF) requiring orthotopic liver transplantation (OLT). His AA did not recover spontaneously and he required treatment with ATG 9 months post-OLT. Bone marrow recovery occurred 4 months after immunotherapy and coincided with further intensification of immunusuppression required to treat early chronic rejection of the liver graft. Three years post-OLT he remains well with good bone marrow and liver function. Intensification of immunosuppression can lead to successful resolution of AA associated with non-A-E ALF.
Rajwal
S R
SR
Children's Liver and G.I. Unit, St James's University Hospital, Leeds, UK. sanjay.rajwal@leedsth.nhs.uk
Davison
S M
SM
Stringer
M D
MD
Kinsey
S E
SE
McClean
P
P
D000293:Adolescent; D000741:Anemia, Aplastic / Q000209:etiology* / Q000601:surgery*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017114:Liver Failure, Acute / Q000150:complications* / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents