CXCR3 polymorphisms associated with risk of asthma.
The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G > A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G > A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.
Cheong
Hyun Sub
HS
Department of Genetic Epidemiology, SNP Genetics, Inc., WooLim Lion's Valley, 371-28, Seoul 153-803, Republic of Korea.
Park
Choon-Sik
CS
Kim
Lyoung Hyo
LH
Park
Byung Lae
BL
Uh
Soo-Taek
ST
Kim
Yong Hooun
YH
Lym
Gune-Il
GI
Lee
Jong-Young
JY
Lee
Jong-Keuk
JK
Kim
Hung Tae
HT
Ryu
Ha-Jung
HJ
Han
Bok Ghee
BG
Kim
Jun Woo
JW
Park
Chan
C
Kimm
Kuchan
K
Shin
Hyoung Doo
HD
Oh
Bermseok
B
D000328:Adult; D001249:Asthma / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution
C515187:CXCR3 protein, human; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine