Is high cerebral perfusion pressure and cerebral flow predictive of impending seizures in preeclampsia? A case report.
Transcranial Doppler ultrasound was used to demonstrate elevated estimated cerebral perfusion pressure (CPP) and cerebral flow index (CFI) in a preeclamptic patient. She subsequently developed eclampsia. After magnesium sulfate therapy her CPP and CFI were within the normal range and she did not experience further seizures. This finding suggests that cerebral overperfusion may be at least one of the etiologies involved in the pathogenesis of eclampsia.
Belfort
Michael A
MA
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Utah, Salt Lake City 84132, USA. uvmbelfo@IHC.com
D000328:Adult; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation / Q000502:physiology; D004461:Eclampsia / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008278:Magnesium Sulfate / Q000627:therapeutic use; D010298:Parity; D011225:Pre-Eclampsia / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D018570:Risk Assessment; D012640:Seizures / Q000175:diagnosis* / Q000503:physiopathology; D017585:Ultrasonography, Doppler, Transcranial
D008278:Magnesium Sulfate