title: Plasma Proteome Database as a resource for proteomics research.
abstract: Plasma is one of the best studied compartments in the human body and serves as an ideal body fluid for the diagnosis of diseases. This report provides a detailed functional annotation of all the plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on proteins previously published in the literature as plasma proteins and the identification of multiple peptides from proteins under HUPO's Plasma Proteome Project. Our analysis revealed that 51% of these genes encoded more than one protein isoform. All single nucleotide polymorphisms involving protein-coding regions were mapped onto the protein sequences. We found a number of examples of isoform-specific subcellular localization as well as tissue expression. This database is an attempt at comprehensive annotation of a complex subproteome and is available on the web at http://www.plasmaproteomedatabase.org.
authors.affiliation: Institute of Bioinformatics, Bangalore, India.
authors.forename: Babylakshmi
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authors.lastname: Muthusamy
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authors.initials: G
authors.lastname: Hanumanthu
authors.forename: Shubha
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authors.lastname: Suresh
authors.forename: B
authors.initials: B
authors.lastname: Rekha
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authors.lastname: Srinivas
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authors.lastname: Karthick
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authors.initials: BM
authors.lastname: Vrushabendra
authors.forename: Salil
authors.initials: S
authors.lastname: Sharma
authors.forename: Goparani
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authors.lastname: Mishra
authors.forename: Pritam
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authors.lastname: Chatterjee
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authors.lastname: Mangala
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authors.lastname: Shivashankar
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authors.lastname: Chandrika
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authors.lastname: Deshpande
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authors.lastname: Suresh
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authors.lastname: Kannabiran
authors.forename: Vidya
authors.initials: V
authors.lastname: Niranjan
authors.forename: Anuradha
authors.initials: A
authors.lastname: Nalli
authors.forename: T S Keshava
authors.initials: TS
authors.lastname: Prasad
authors.forename: K S
authors.initials: KS
authors.lastname: Arun
authors.forename: Raghunath
authors.initials: R
authors.lastname: Reddy
authors.forename: Sreenath
authors.initials: S
authors.lastname: Chandran
authors.forename: Trafina
authors.initials: T
authors.lastname: Jadhav
authors.forename: D
authors.initials: D
authors.lastname: Julie
authors.forename: M
authors.initials: M
authors.lastname: Mahesh
authors.forename: S Lynate
authors.initials: SL
authors.lastname: John
authors.forename: Kshitish
authors.initials: K
authors.lastname: Palvankar
authors.forename: D
authors.initials: D
authors.lastname: Sudhir
authors.forename: P
authors.initials: P
authors.lastname: Bala
authors.forename: N S
authors.initials: NS
authors.lastname: Rashmi
authors.forename: G
authors.initials: G
authors.lastname: Vishnupriya
authors.forename: Kaushik
authors.initials: K
authors.lastname: Dhar
authors.forename: S
authors.initials: S
authors.lastname: Reshma
authors.forename: Raghothama
authors.initials: R
authors.lastname: Chaerkady
authors.forename: T K B
authors.initials: TK
authors.lastname: Gandhi
authors.forename: H C
authors.initials: HC
authors.lastname: Harsha
authors.forename: S Sujatha
authors.initials: SS
authors.lastname: Mohan
authors.forename: Krishna S
authors.initials: KS
authors.lastname: Deshpande
authors.forename: Malabika
authors.initials: M
authors.lastname: Sarker
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
mesh_terms: D020816:Amino Acid Motifs; D001798:Blood Proteins / Q000737:chemistry* / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D015894:Genome, Human; D006801:Humans; D013058:Mass Spectrometry; D010455:Peptides / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms; D017434:Protein Structure, Tertiary; D040901:Proteomics / Q000379:methods*; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D010455:Peptides; D020033:Protein Isoforms