[Acute enterovirus uveitis in infants].
Enterovirus uveitis (EU) is a new infant eye disease that was first detected and identified in Russia in 1980-1981. Three subtypes of human echoviruses (EV19K, EV11A, and EV11/B) caused 5 nosocomial outbreaks of EU in different Siberian cities and towns in 1980-1989, by affecting more than 750 children mainly below one year of age. Sporadic and focal EU cases (more than 200) were also retrospectively diagnosed in other regions of Russia and in different countries of the former Soviet Union. There were following clinical manifestations: common symptoms of the infection; acute uveitis (rapid focal iridic destruction, pupillary deformities, formation of membranes in the anterior chamber of the eye); and in 15-30% of cases severe complications, cataract, glaucoma, vision impairments. Uveitis strains EV19 and EV11 caused significant uveitis in primates after inoculation into the anterior chamber of the eye, as well as sepsis-like fatal disease with liver necrosis after venous infection. The uveitis strains are phylogenetically and pathogenetically close for primates to strains EV19 and EV11 isolated from young children with sepsis-like disease. The contents of this review have been published in the Reviews in Medical Virology, 2004, vol. 14, p. 241-254.
Lashkevich
V A
VA
Koroleva
G A
GA
Lukashev
A N
AN
Denisova
E V
EV
Katargina
L A
LA
Khoroshilova-Maslova
I P
IP
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D002386:Cataract / Q000209:etiology; D003429:Cross Reactions; D004195:Disease Models, Animal; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D029822:Enterovirus B, Human / Q000235:genetics / Q000276:immunology; D005123:Eye / Q000821:virology; D005901:Glaucoma / Q000209:etiology; D006801:Humans; D007223:Infant; D007498:Iris / Q000473:pathology; D017720:Molecular Epidemiology; D009500:Neutralization Tests; D010802:Phylogeny; D011323:Primates; D011681:Pupil Disorders; D012367:RNA, Viral / Q000235:genetics; D012426:Russia / Q000453:epidemiology; D014605:Uveitis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D014786:Vision Disorders / Q000209:etiology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D012367:RNA, Viral