Infantile case of occlusive microvascular retinopathy after bone marrow transplantation.
BACKGROUND
A variety of anterior and posterior segment ocular complications following bone marrow transplantation (BMT) have been well documented in adults and children, but retinal complications after BMT in infants have rarely been reported.


METHODS
A 6-month-old male infant developed occlusive microvascular retinopathy after BMT to treat acute lymphocytic leukemia.


METHODS
Four months after the transplantation, retinal edema, hemorrhage, soft exudates, and neovascularization were found in the posterior pole fundus of the right eye and in the peripheral fundus of the left eye. After oral prednisolone was administered, the retinal lesions regressed and cicatrices with chorioretinal atrophy and fibrous tissue formed.


CONCLUSIONS
Neovascularization following occlusive microvascular retinopathy after BMT in infant eyes responds well to oral prednisolone. The visual prognosis depends on the foveal involvement of the retinopathy.
Kawase
Eriko
E
Department of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan. kawase@eye-center.org
Azuma
Noriyuki
N
Shioda
Yoko
Y
Kumagai
Masaaki
M
D000284:Administration, Oral; D001284:Atrophy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002829:Choroid / Q000473:pathology; D004596:Electroretinography; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000601:surgery; D011239:Prednisolone / Q000627:therapeutic use; D012160:Retina / Q000473:pathology; D012166:Retinal Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015861:Retinal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D019172:Transplantation Conditioning
D005938:Glucocorticoids; D011239:Prednisolone