title: Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis.
abstract: Tazarotene and calcipotriol are both effective in the treatment of psoriasis. An investigator-blind, bilateral comparison of 44 lesion pairs in 19 patients was conducted to evaluate the efficacy, side effects and duration of therapeutic effects of once-daily tazarotene 0.1% gel plus petrolatum with twice-daily calcipotriol 0.005% ointment in plaque psoriasis. It consisted of a 12-week treatment phase, followed by a 4-week post-treatment observation phase. At the end of the treatment phase, tazarotene-petrolatum was as effective as calcipotriol in both objective and subjective overall efficacy assessment. Calcipotriol had a significantly greater effect in reducing erythema than tazarotene-petrolatum at weeks 2-8. At week 16, tazarotene-petrolatum demonstrated a significantly better maintenance effect in all parameters. Local irritation was noted only in tazarotene-petrolatum-treated lesions. Once-daily tazarotene 0.1% gel plus petrolatum was as effective as twice-daily calcipotriol 0.005% ointment in the treatment of plaque psoriasis, but had a better maintenance effect after the cessation of therapy.
authors.affiliation: Department of Dermatology, Veterans General Hospital-Kaohsiung, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan. tytzung@isca.vghks.gov.tw
authors.forename: Tien-Yi
authors.initials: TY
authors.lastname: Tzung
authors.forename: Jen-Chin
authors.initials: JC
authors.lastname: Wu
authors.forename: Nei-Jen
authors.initials: NJ
authors.lastname: Hsu
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Chen
authors.forename: Luo-Ping
authors.initials: LP
authors.lastname: Ger
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000008:administration & dosage*; D009824:Ointments; D010577:Petrolatum / Q000008:administration & dosage; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D012176:Retinoids
chemical_list: D002117:Calcitriol; D003879:Dermatologic Agents; D005782:Gels; D009539:Nicotinic Acids; D009824:Ointments; D010577:Petrolatum; C055085:calcipotriene; C086827:tazarotene; D012176:Retinoids