title: Sentinel node biopsy in squamous cell cancer of the oral cavity and oral pharynx: a diagnostic meta-analysis.
abstract: BACKGROUND
  The sentinel node biopsy concept has been gaining support in the head and neck cancer literature during only the last few years, and several pilot studies have been published. This procedure aims to avoid unnecessary treatment to the clinically negative neck by identifying the patients with occult neck disease.
  
  
  METHODS
  We performed a systematic review and a diagnostic meta-analysis of all published literature regarding sentinel node biopsies in head and neck cancer until December 2003 using established guidelines. Using the pooled sensitivity rates obtained from the meta-analysis and treatment outcomes from published literature, we created a decision analysis model to identify the treatment arm with better payoffs.
  
  
  RESULTS
  A total of 301 patients with oral cavity primary tumors and 46 patients with oropharyngeal primary tumors from 19 articles were included for the meta-analysis. The pooled sensitivity result using the random effects model was 0.926 (95% confidence interval, 0.852-0.964). The cumulative payoff for the sentinel node biopsy arm was lower than that for the elective node dissection arm by about 1%. The payoffs were assigned for the recurrence and mortality rates only and did not take into account the morbidity caused by the procedures.
  
  
  CONCLUSIONS
  The sentinel node biopsy procedure has shown high sensitivity rates in pilot studies for oral and oropharyngeal squamous cell cancer across the globe and is reliable and reproducible. This study provides a firm evidence base for forthcoming trials on the role of sentinel node biopsy in head and neck cancer.
authors.affiliation: Otolaryngology-Head-Neck Surgery, Freeman Hospital, Newcastle upon Tyne, UK. vinidh.paleri@nuth.nhs.uk
authors.forename: Vinidh
authors.initials: V
authors.lastname: Paleri
authors.forename: Guy
authors.initials: G
authors.lastname: Rees
authors.forename: Puveendran
authors.initials: P
authors.lastname: Arullendran
authors.forename: Taimur
authors.initials: T
authors.lastname: Shoaib
authors.forename: Suren
authors.initials: S
authors.lastname: Krishman
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000401:mortality; D003663:Decision Trees; D006801:Humans; D008197:Lymph Node Excision; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000401:mortality; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D010610:Pharyngeal Neoplasms / Q000175:diagnosis* / Q000401:mortality; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy