title: A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population.
abstract: Lipid abnormalities are strongly linked with coronary heart disease and are common in type 2 diabetes. However, little is known about the genetic determinants of serum lipids in African populations. An autosomal genome scan was performed for linkage to five plasma lipid phenotypes (total cholesterol, triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and VLDL-cholesterol (VLDL-C)) in the Africa-America Diabetes Mellitus (AADM) study. Two hundred and ninety-five affected sibling pairs with type 2 diabetes mellitus enrolled from Ghana and Nigeria were genotyped for 390 microsatellite markers with an average inter-marker distance of 9cM. Multipoint variance components linkage analysis showed that HDL-C had a LOD score of 4.34 near marker D7S3061 and 3.00 near marker D7S513. Some clustering of linkage evidence to several lipid phenotypes was observed on chromosomes 5 (LDL-C, total cholesterol, VLDL-C), chromosome 7 (HDL-C, TG) and chromosome 19 (total cholesterol, LDL-C, TG). Principal component analysis of the five phenotypes yielded two factors, one (TG, HDL-C and VLDL) of which was linked to QTLs on chromosomes 2, 5 and 7, while the other (total cholesterol and LDL-C) was linked to a different set of QTLs on chromosomes 2, 5 and 18. Several of these regions have been reported to be linked to lipids in other studies. Follow up investigations are warranted in view of the central role serum lipids play in the aetiopathogenesis of cardiovascular disease.
authors.affiliation: National Human Genome Center, Howard University, Genetic Epidemiology Unit, College of Medicine, 2216 6th Street, NW, Washington, DC 20059, USA.
authors.forename: Adebowale A
authors.initials: AA
authors.lastname: Adeyemo
authors.forename: Thomas
authors.initials: T
authors.lastname: Johnson
authors.forename: Joseph
authors.initials: J
authors.lastname: Acheampong
authors.forename: Johnnie
authors.initials: J
authors.lastname: Oli
authors.forename: Godfrey
authors.initials: G
authors.lastname: Okafor
authors.forename: Albert
authors.initials: A
authors.lastname: Amoah
authors.forename: Samuel
authors.initials: S
authors.lastname: Owusu
authors.forename: Kofi
authors.initials: K
authors.lastname: Agyenim-Boateng
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Eghan
authors.forename: Fayeofori
authors.initials: F
authors.lastname: Abbiyesuku
authors.forename: Olufemi
authors.initials: O
authors.lastname: Fasanmade
authors.forename: Theresa
authors.initials: T
authors.lastname: Rufus
authors.forename: Ayo
authors.initials: A
authors.lastname: Doumatey
authors.forename: Guanjie
authors.initials: G
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Yuanxiu
authors.initials: Y
authors.lastname: Chen
authors.forename: Paulette
authors.initials: P
authors.lastname: Furbert-Harris
authors.forename: Georgia
authors.initials: G
authors.lastname: Dunston
authors.forename: Francis
authors.initials: F
authors.lastname: Collins
authors.forename: Charles
authors.initials: C
authors.lastname: Rotimi
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D023281:Genomics; D005838:Genotype; D005869:Ghana / Q000208:ethnology; D006801:Humans; D008126:Lod Score; D008875:Middle Aged; D009549:Nigeria / Q000208:ethnology; D040641:Quantitative Trait Loci; D014481:United States / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D002784:Cholesterol