title: [Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study].
abstract: The P300 component of the event-related potential (ERP) is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS) to process incoming information.
  
  
  OBJECTIVE
  To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300), in relation to a P300 normative database.
  
  
  METHODS
  15 right-handed individuals (7 male and 8 female), between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design.
  
  
  RESULTS
  Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database.
  
  
  CONCLUSIONS
  The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning.
authors.affiliation: Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, IPUB, Brazil. marianamoliveira@yahoo.com
authors.forename: Mariana
authors.initials: M
authors.lastname: Montenegro
authors.forename: Heloisa
authors.initials: H
authors.lastname: Veiga
authors.forename: Andréa
authors.initials: A
authors.lastname: Deslandes
authors.forename: Maurício
authors.initials: M
authors.lastname: Cagy
authors.forename: Kaleb
authors.initials: K
authors.lastname: McDowell
authors.forename: Fernando
authors.initials: F
authors.lastname: Pompeu
authors.forename: Roberto
authors.initials: R
authors.lastname: Piedade
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001960:Bromazepam / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004311:Double-Blind Method; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D018377:Neurotransmitter Agents; D002110:Caffeine; D001960:Bromazepam