title: [Effectiveness of Nao'an Capsule on stroke prevention among high risk population in Nanhui, Shanghai].
abstract: OBJECTIVE
  To evaluate the effectiveness of stroke prevention among high risk population, using Nao'an Capsules.
  
  
  METHODS
  Participants were selected from 696,558 residents in Nanhui, using county of Shanghai city. Individuals aged 35 years old and over with at least one risk factor exposure to stroke, received cerebral vascular hemodynamic examination. 18,271 cases meeting the criteria of cerebral vascular hemodynamic indexes accumulative score below 70 points were defined as individuals with high-risk and targets to receive intervention. According to the willingness of the participants, 10,313 cases received Nao'an Capsules for intensive intervention based on general intervention measures compared to 7958 cases only receiving general intervention. After the implementation of intervention, incidence and mortality rates of stroke and the effectiveness of three-year intervention were studied.
  
  
  RESULTS
  Incidence of stroke in Nao'an Capsules group was significantly lower than that of the general intervention (P < 0.01) with 53.8% in males and 58.4% in females. The relative risk (RR) in two gender groups were 0.46 (0.33 - 0.64) and 0.39 (0.30 - 0.50) respectively. Multiple logistic regression analysis indicated that the history of hypertension, accumulative score of cerebral vascular hemodynamic indexes, age, gender and Nao'an Capsules intervention were the variables selected into the equation and significantly related to stroke. Among the variables, Nao'an Capsule was the strongest factor with a RR of 0.41.
  
  
  CONCLUSIONS
  Incidence of stroke in Nao'an Capsule intervention group was significantly lower than that in the general intervention group after 3 years of intervention, suggesting that Nao'an Capsule intervention was the strongest factor affecting stroke occurrence in individuals at high-risk.
authors.affiliation: Shanghai Institute of Cerebral Vascular Disease Intervention and Cure, Shanghai 201318, China.
authors.forename: Gui-qing
authors.initials: GQ
authors.lastname: Wang
authors.forename: Jiu-yi
authors.initials: JY
authors.lastname: Huang
authors.forename: Feng-ying
authors.initials: FY
authors.lastname: Shen
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Cao
authors.forename: Ji-ping
authors.initials: JP
authors.lastname: Guo
authors.forename: Xue-hai
authors.initials: XH
authors.lastname: Yu
authors.forename: Wei-yan
authors.initials: WY
authors.lastname: Mou
authors.forename: Su-chun
authors.initials: SC
authors.lastname: Wang
authors.forename: Yong-ju
authors.initials: YJ
authors.lastname: Yang
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Lin
authors.forename: Guo-xin
authors.initials: GX
authors.lastname: Fu
mesh_terms: D000328:Adult; D000368:Aged; D002214:Capsules; D002681:China / Q000453:epidemiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006266:Health Education; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal