title: [Investigation of solubility properties of nifluminic acid containing cyclodextrins and polyvidone].
abstract: One of the most important task of the pharmaceutical technology is to reach a possible high gastrointestinal absorbtion of the active ingredient. Therefore, it is necessary to have a good solubility in the gastric/intestinal medium. In this way the applied drug quantity and unwanted side effects can be reduced with solubility increasing. The water-insoluble drug's solubility and bioavailability can be increased by the alteration of their physicochemical properties. Nifluminic acid is a frequently used anti-inflammatory drug with low aqueous solubility. Inclusion complexation with cyclodextrins is an efficacious method to improve the solubility, stability and bioavailability. Ternary systems were prepared and investigated to use nifluminic acid, hydoxypropyl-beta-cyclodextrin and polyvidone. The aims of the study were to investigate the solubility rate, the in vitro diffusion ability, to determine the n-octanol/water partition coefficient, and to study the thermoanalitycal properties of products. The results suggested that complexation with cyclodextrin and the use of polyvidone is better method than to prepare binary systems. Inclusion complexation was presumed in the event of the ternary composition to improve the bioavailability of nifluminic acid.
authors.affiliation: Szegedi Tudományegyetem, Gyógyszerésztudományi Kar, Gyógyszertechnológiai Intézet, Szeged, Eötvös.
authors.forename: Rita
authors.initials: R
authors.lastname: Ambrus
authors.forename: Mihály
authors.initials: M
authors.lastname: Kata
authors.forename: István
authors.initials: I
authors.lastname: Eros
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Aigner
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004338:Drug Combinations; D006801:Humans; D007408:Intestinal Absorption; D009544:Niflumic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D011205:Povidone / Q000737:chemistry*; D012995:Solubility
chemical_list: D003505:Cyclodextrins; D004338:Drug Combinations; D009544:Niflumic Acid; D011205:Povidone