title: Cerebellar atrophy in temporal lobe epilepsy.
abstract: OBJECTIVE
  The goal of this work was to determine the presence and degree of cerebellar atrophy in chronic temporal lobe epilepsy, its clinical seizure correlates, and its association with general cortical atrophy.
  
  
  METHODS
  Study participants were 78 persons with temporal lobe epilepsy and 63 age- and gender-matched healthy controls. All subjects underwent high-resolution MRI with manual tracing of the cerebellum. Clinical seizure features and history were obtained by structured interview and review of medical records.
  
  
  RESULTS
  The epilepsy group exhibited significant abnormality in cerebellar volume, with mean reductions ranging from 4 to 6.6% depending on adjustments. Significantly more individual subjects with epilepsy exhibited cerebellar atrophy compared with controls across all operational definitions or thresholds of abnormality including z < or = -2.0 (13% TLE, 3.4% controls) and z < or = 1.5 (22% TLE, 3.4% controls). Clinical seizure features reflecting both neurodevelopmental (history of initial precipitating injuries) and severity of course (longer duration, increased number of lifetime generalized tonic-clonic seizures) factors were associated with cerebellar atrophy. Atrophy of the cerebellum could be observed independent of more general (cerebral) atrophic processes.
  
  
  CONCLUSIONS
  The presence of cerebellar atrophy is a reflection of the extratemporal abnormalities that can be observed in localization-related temporal lobe epilepsy, which may be due, at least in part, to factors associated with epilepsy chronicity.
authors.affiliation: Department of Neurology, University of Wisconsin, Madison, WI 53792, USA. hermann@neurology.wisc.edu
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Hermann
authors.forename: Katherine
authors.initials: K
authors.lastname: Bayless
authors.forename: Russ
authors.initials: R
authors.lastname: Hansen
authors.forename: Joy
authors.initials: J
authors.lastname: Parrish
authors.forename: Michael
authors.initials: M
authors.lastname: Seidenberg
mesh_terms: D000328:Adult; D000367:Age Factors; D001284:Atrophy; D016022:Case-Control Studies; D002531:Cerebellum / Q000473:pathology*; D018450:Disease Progression; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data; D008875:Middle Aged; D012196:Review Literature as Topic