title: Gaining weight: the Keystone Symposium on PPAR and LXR.
abstract: The nuclear receptor superfamily consists of 48 mammalian transcription factors that regulate nearly all aspects of development, inflammation, and metabolism. Two subclasses, the Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs), are lipid-sensing receptors that have critical roles in lipid and glucose metabolism. The parallel epidemics of obesity and diabetes shine a spotlight on the potential for therapeutic manipulation of PPARs and LXRs to combat these diseases. In recognition of this, a recent Keystone Symposium was devoted to these metabolic receptors. Here, we summarize some of the major highlights and future projections discussed at the meeting.
authors.affiliation: Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Lehrke
authors.forename: Gabriel
authors.initials: G
authors.lastname: Pascual
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Glass
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Lazar
mesh_terms: D017667:Adipocytes / Q000502:physiology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D015894:Genome, Human; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008024:Ligands; D050356:Lipid Metabolism; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*; D015430:Weight Gain
chemical_list: D004268:DNA-Binding Proteins; D008024:Ligands; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047492:Peroxisome Proliferator-Activated Receptors; D018160:Receptors, Cytoplasmic and Nuclear