Modifications in avoidance reactions of mice, on a second exposure to the hot plate, resist to various amnesia-inducing treatments.
The avoidance responses of mice exposed to the hot plate (55 degrees C) were found to be modified when tested a second time. In fact, when forepaws licking was no longer observed, the rearing was clearly anticipated (7 s instead of 15 s) as well as jumping (24 s instead of 55 s). These modifications of avoidance strategies as well as their latencies were still observed even 24 days after the first exposure. Avoidance responses were prevented by morphine or haloperidol injected prior to the first exposure, but not with scopolamine or diazepam. These modifications were not affected in mice injected with morphine or submitted to either a supramaximal electroshock or to ether anesthesia delivered immediately after the first hot plate exposure. Among the various known types of memory, these modifications could be linked to procedural memory.
Suaudeau
Charles
C
IFRMP 23, Unité de Neuropsychopharmacologie Expérimentale, CNRS FRE 2735, U.F.R. de Médecine et Pharmacie, 76183 Rouen Cedex, France.
do-Rego
Jean-Claude
JC
Costentin
Jean
J
D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal; D003704:Dementia / Q000209:etiology / Q000517:prevention & control*; D003975:Diazepam / Q000008:administration & dosage; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock / Q000009:adverse effects; D004986:Ether / Q000627:therapeutic use; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000008:administration & dosage; D009294:Narcotics / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000008:administration & dosage; D013697:Thermosensing / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D000927:Anticonvulsants; D018492:Dopamine Antagonists; D018727:Muscarinic Antagonists; D009294:Narcotics; D004986:Ether; D009020:Morphine; D012601:Scopolamine; D006220:Haloperidol; D003975:Diazepam