title: Tridemethylisovelleral, a potent cytotoxic agent.
abstract: The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaldehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral.
authors.affiliation: Department of Organic Chemistry, Lund University, PO Box 124, S-221 00 Lund, Sweden.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Aujard
authors.forename: Daniel
authors.initials: D
authors.lastname: Röme
authors.forename: Erwan
authors.initials: E
authors.lastname: Arzel
authors.forename: Martin
authors.initials: M
authors.lastname: Johansson
authors.forename: Dick
authors.initials: D
authors.lastname: de Vos
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C507089:tridemethylisovelleral; C089286:isovelleral