title: Isolation and characterization of 1,3-dicapryloyl-2-linoleoylglycerol: a novel triglyceride from berries of Hippophae rhamnoides.
abstract: 1,3-Dicapryloyl-2-linoleoylglycerol (1), a novel triglyceride, was isolated from berries of Hippophae rhamnoides. The structure was elucidated on the basis of MS, 1D and 2D NMR experiments including HMQC and HMBC. The metal chelating, free radical scavenging, and lipid peroxidation inhibiting properties of the compound were also estimated with particular reference to radiation protection. In case of metal chelation and superoxide ion scavenging, 1 showed maximum inhibition at 50 microg/ml (11%) and 100 microg/ml (55%), respectively, whereas in lipid peroxidation, 1 showed maximum inhibition (57%) at 2 mg/ml as compared to quercetin as a control.
authors.affiliation: Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur, H.P.-176061, India.
authors.forename: Anand
authors.initials: A
authors.lastname: Swaroop
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Sinha
authors.forename: Raman
authors.initials: R
authors.lastname: Chawla
authors.forename: Rajesh
authors.initials: R
authors.lastname: Arora
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Sharma
authors.forename: Jonala Kotesh
authors.initials: JK
authors.lastname: Kumar
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002614:Chelating Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004075:Diglycerides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D031281:Hippophae / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C504499:1,3-dicapryloyl-2-linoleoylglycerol; D000975:Antioxidants; D002614:Chelating Agents; D004075:Diglycerides