title: [Role of platelet activating factor in hepatorenal syndrome].
abstract: OBJECTIVE
  To investigate the relationship between platelet activating factor (PAF) and occurrence of hepatorenal syndrome (HRS).
  
  
  METHODS
  A total of 57 cases of patients with liver cirrhosis or hepatitis gravis were enrolled. The serum concentrations of PAF, lipopolysaccharide (LPS) and prothrombin activity (PTA), total bilirubin, and serum creatinine were detected in patients combined with HRS and in patients without HRS in hospital at the term. The correlations among the PAF, LPS, and the function of liver and kidney were analyzed.
  
  
  RESULTS
  The concentrations of PAF and LPS in the patients combined with HRS were significantly higher than those patients without HRS. There were linear correlations between the PAF and LPS level, the total bilirubin level and PAF level, the PAF level and serum creatinine level.
  
  
  CONCLUSIONS
  The PAF associates with the occurrence of HRS. The PAF may mediate the occurrence of HRS induced by LPS. The PAF level may forecast whether patients with liver failure will take place HRS.
authors.affiliation: Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Xie
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Xie
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006530:Hepatorenal Syndrome / Q000378:metabolism*; D006801:Humans; D008297:Male; D010972:Platelet Activating Factor / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D010972:Platelet Activating Factor