Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma.
OBJECTIVE
In order to clarify clinical efficacy of commercially available 5-fluorouracil (5-FU) topical cream, a clinical study was conducted.


METHODS
Two to three cubic millimetres of 5-FU topical cream (Kyowa, Roche) was applied on 50 cases of various types of cholesteatoma (50 patients) two to five times with the interval of 2 weeks, and its clinical efficacy was evaluated by the criteria we developed.


RESULTS
In total, 59% of the cholesteatomas showed good effect, 29% of them showed fair effect, and the effect was poor in the remaining 12%. It was particularly effective in cholesteatomas in the EAC, attic cholesteatomas with an aerated mastoid, and in recurrent-type cholesteatomas.


CONCLUSIONS
5-FU topical cream appeared effective for the treatment of cholesteatomas.
Takahashi
Haruo
H
Division of Otorhinolaryngology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. htak0831@net.nagasaki-u.ac.jp
Funabiki
Kazuo
K
Hasebe
Seishi
S
Fukuda-Yamamoto
Tomomi
T
Kaieda
Satoru
S
Iwanaga
Tetsu
T
Kumagami
Hidetaka
H
Takasaki
Kenji
K
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002781:Cholesteatoma / Q000188:drug therapy* / Q000473:pathology; D004427:Ear Diseases / Q000188:drug therapy* / Q000473:pathology; D004431:Ear, External / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil