Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis.
Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.
Felipe
Maria Sueli S
MS
Departamento de Biologia Celular, Laboratório de Biologia Molecular, Instituto de Biologia, Universidade de Brasília. msueli@unb.br
Torres
Fernando A G
FA
Maranhão
Andrea Q
AQ
Silva-Pereira
Ildinete
I
Poças-Fonseca
Marcio J
MJ
Campos
Elida G
EG
Moraes
Lídia M P
LM
Arraes
Fabrício B M
FB
Carvalho
Maria José A
MJ
Andrade
Rosângela V
RV
Nicola
André M
AM
Teixeira
Marcus M
MM
Jesuíno
Rosália S A
RS
Pereira
Maristela
M
Soares
Célia M A
CM
Brígido
Marcelo M
MM
D020224:Expressed Sequence Tags; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D016681:Genome, Fungal; D006801:Humans; D010228:Paracoccidioides / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity; D010229:Paracoccidioidomycosis / Q000382:microbiology*; D014158:Transcription, Genetic
D005656:Fungal Proteins