title: Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and Positron Emission Tomography.
abstract: OBJECTIVE
  Parametric analysis of (15)O-water positron emission tomography (PET) studies allows determination of blood flow (BF), perfusable tissue fraction (PTF), and volume of distribution (V (d)) with high spatial resolution. In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated.
  
  
  METHODS
  Monte Carlo simulations were performed using typical perfusion values for brain, tumor, and heart. Clinical evaluation was performed using seven cerebral and 10 myocardial (15)O-water PET studies. Basis function (BFM), linear least squares (LLS), and generalized linear least squares (GLLS) methods were used to calculate BF, PTF, or V(d).
  
  
  RESULTS
  Monte Carlo simulations and human studies showed that, for low BF values (<1 ml/min(-1)ml(-1), BF, PTF, and V(d) were calculated with accuracies better than 5% for all methods tested. For high BF (>2 ml/min(-1)ml(-1)), use of BFM provided more accurate V(d) compared with (G)LLS.
  
  
  CONCLUSIONS
  In general, BFM provided the most accurate estimates of BF, PTF, and V(d).
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands. r.boellaard@vumc.nl
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.forename: Paul
authors.initials: P
authors.lastname: Knaapen
authors.forename: Abraham
authors.initials: A
authors.lastname: Rijbroek
authors.forename: Gert J J
authors.initials: GJ
authors.lastname: Luurtsema
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply*; D003331:Coronary Vessels / Q000033:anatomy & histology; D006801:Humans; D016018:Least-Squares Analysis; D016014:Linear Models; D008955:Models, Cardiovascular; D009010:Monte Carlo Method; D009369:Neoplasms / Q000098:blood supply*; D010104:Oxygen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D014867:Water / Q000378:metabolism*
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water