title: Heparan sulphate proteoglycans: the sweet side of development.
abstract: Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
authors.affiliation: Department of Experimental Medical Science, Lund Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden. udo.hacker@med.lu.se
authors.forename: Udo
authors.initials: U
authors.lastname: Häcker
authors.forename: Kent
authors.initials: K
authors.lastname: Nybakken
authors.forename: Norbert
authors.initials: N
authors.lastname: Perrimon
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006025:Glycosaminoglycans / Q000096:biosynthesis; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D015398:Signal Transduction
chemical_list: D006025:Glycosaminoglycans; D019812:Heparan Sulfate Proteoglycans