Cell therapy plus transmyocardial laser revascularization for refractory angina.
We describe the use of autologous bone marrow cells combined with transmyocardial laser revascularization in a 74-year-old man with refractory angina. Baseline cardiac magnetic resonance imaging revealed a markedly depressed left ventricle systolic function and an extensive area of myocardial ischemia. During surgery, 11 laser shots using a CO2 Heart Laser System (PLC Medical Systems, Milford, MA) were fired and a 5-mL cell suspension containing 21.5 x 10(6) bone marrow cells/mL was delivered by multiple injections into the myocardium. At 6 months after the procedure, another cardiac magnetic resonance imaging showed an almost complete resolution of the perfusion defect and an improvement in left ventricular contractility.
Gowdak
Luís Henrique W
LH
Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil. luis.gowdak@incor.usp.br
Schettert
Isolmar T
IT
Rochitte
Carlos Eduardo
CE
Lisboa
Luiz Augusto F
LA
Dallan
Luís Alberto O
LA
César
Luiz Antônio M
LA
Krieger
José Eduardo
JE
Ramires
José Antônio F
JA
Oliveira
Sérgio A de
SA
D000368:Aged; D000789:Angina, Unstable / Q000628:therapy*; D016026:Bone Marrow Transplantation; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009204:Myocardial Revascularization / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000628:therapy*