In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.
The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates.
Philip
Annie
A
Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas-Houston Medical School, 6431 Fannin, MSB 2.112, Houston, TX 77030, USA.
Odabasi
Zekaver
Z
Rodriguez
Jose
J
Paetznick
Victor L
VL
Chen
Enuo
E
Rex
John H
JH
Ostrosky-Zeichner
Luis
L
D000666:Amphotericin B / Q000494:pharmacology; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000145:classification / Q000187:drug effects*; D004357:Drug Synergism; D054714:Echinocandins; D005670:Fusarium / Q000145:classification / Q000187:drug effects*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D000077612:Anidulafungin; D065819:Voriconazole