title: Nitric oxide in wound-healing.
abstract: Modulation of the complex process of wound-healing remains a surgical challenge. Little improvement beyond controlling infection, gentle tissue handling, and debridement of necrotic tissue has been had in the modern era. However, increasing appreciation of the process from a biomolecular perspective offers the potential for making significant strides in wound modulation. The bioactive molecule nitric oxide was found to have wide-ranging impact on cellular activities, including the cellular responses engendered by wound healing. Current research suggests that nitric oxide and several nitric oxide donors can exert biologic effects, although the particular net responses of cells contributing to wound repair are context-dependent.
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1500, USA. isenberj@mail.nih.gov
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Isenberg
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Ridnour
authors.forename: Michael Graham
authors.initials: MG
authors.lastname: Espey
authors.forename: David A
authors.initials: DA
authors.lastname: Wink
authors.forename: David D
authors.initials: DD
authors.lastname: Roberts
mesh_terms: D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy
chemical_list: D009569:Nitric Oxide