title: Antineoplastic effects of butanolic residue of Pfaffia paniculata.
abstract: We have previously reported a reduction in the accumulation of ascitic fluid in Ehrlich tumor-bearing mice following treatment with the powdered roots of Pfaffia paniculata. The aim of this study was to investigate which extracts from these roots presented antineoplastic properties. Thus, the effects of the ethanolic extract, butanolic residue, or aqueous residue from Pfaffia paniculata on animal survival and tumor growth in mice bearing this tumor were studied. Butanolic residue-treated mice survived longer than untreated mice. This result points to an antineoplastic effect exerted by the butanolic fraction from the roots of P. paniculata on this tumor model.
authors.affiliation: Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, CEP 05508-900, São Paulo-SP, Brazil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Matsuzaki
authors.forename: Mitsue
authors.initials: M
authors.lastname: Haraguchi
authors.forename: Gokithi
authors.initials: G
authors.lastname: Akisue
authors.forename: Sílvia Catarina Salgado
authors.initials: SC
authors.lastname: Oloris
authors.forename: Márcia Kazumi
authors.initials: MK
authors.lastname: Nagamine
authors.forename: Tereza Cristina
authors.initials: TC
authors.lastname: da Silva
authors.forename: Monica
authors.initials: M
authors.lastname: Sakai
authors.forename: Evelise
authors.initials: E
authors.lastname: de Souza Monteiro Fonseca
authors.forename: João
authors.initials: J
authors.lastname: Palermo-Neto
authors.forename: Silvana Lima
authors.initials: SL
authors.lastname: Górniak
authors.forename: Maria Lúcia Zaidan
authors.initials: ML
authors.lastname: Dagli
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000627:therapeutic use*; D000440:Butanols / Q000737:chemistry*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D000431:Ethanol / Q000737:chemistry; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D015996:Survival Rate; D014867:Water / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000440:Butanols; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000431:Ethanol