title: Design and initial evaluation of an implantable sonomicrometer and CW Doppler flowmeter for simultaneous recordings with a multichannel telemetry system.
abstract: We have developed a sonomicrometer and continuous wavelength (CW) Doppler flowmeter for a multichannel telemetry system. These developments will enable us to measure ventricular dimension and coronary artery blood velocity, which are valuable parameters to characterize sudden cardiac death (SCD) in ambulatory animal models of ventricular arrhythmias. The design goals for the sensors were accuracy, low power consumption, small size and compatibility with each other. The circuits were designed successfully and tested simultaneously in vivo. The CW Doppler flowmeter draws 9 mA and the sonomicrometer draws 28 mA on a 5-V supply. The ability to measure heart dimension and blood velocity will add significantly to our understanding of the sequence of events leading up to spontaneous sudden cardiac death.
authors.affiliation: Biomedical Engineering Department, University of Alabama at Birmingham, Birmingham, AL 35294, USA. wei@crml.uab.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Kong
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Rollins
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Ideker
authors.forename: William M
authors.initials: WM
authors.lastname: Smith
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D018056:Hemorheology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods; D019736:Prostheses and Implants; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods; D018617:Ultrasonography, Doppler, Pulsed / Q000295:instrumentation* / Q000379:methods