Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice.
In mice, vancomycin and linezolid treatment disrupted the anaerobic intestinal microflora, based on denaturing gradient gel electrophoresis analysis, and promoted colonization by Klebsiella pneumoniae and vancomycin-resistant enterococci. However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen.
Pultz
Nicole J
NJ
Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, Ohio 44106, USA.
Stiefel
Usha
U
Donskey
Curtis J
CJ
D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000254:growth & development; D017576:Daptomycin / Q000008:administration & dosage / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D000069349:Linezolid; D051379:Mice; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D014640:Vancomycin / Q000008:administration & dosage / Q000494:pharmacology*; D020713:Vancomycin Resistance; D001618:beta-Lactamases / Q000378:metabolism
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D001618:beta-Lactamases; D000069349:Linezolid; D017576:Daptomycin