Risk factors for primary liver carcinoma in Chinese population.
OBJECTIVE
To evaluate the risk factors for primary liver carcinoma (PLC) in Chinese population.


METHODS
Chinese Biomedical Literature Database, China Hospital Knowledge Database and MEDLINE were searched. All the related literatures were screened, and the risk factors for PLC in Chinese population were studied. Heterogeneity was evaluated by odds ratio (OR) q test. Combined OR and its 95% confidence interval (95%CI) were calculated, the association between the investigated risk factors and PLC was determined. Validity and bias of the findings were evaluated by sensitivity analysis and funnel plot analysis respectively.


RESULTS
Fifty-five of one hundred and ninety identified studies were accepted according to the inclusive criteria. Ten factors related to PLC were demonstrated by sensitive analysis and funnel plot analysis. They were cirrhosis (OR = 11.97, P = 0.000), HBV infection (OR = 11.34, P = 0.000), HCV infection (OR = 4.28, P = 0.000), family history of liver cancer (OR = 3.49, P = 0.000), unstable emotion (OR = 2.20, P = 0.000), depressed characters (OR = 3.07, P = 0.000), aflatoxin (OR = 1.80, P = 0.000), alcoholic (OR = 1.88, P = 0.000), intake of musty food (OR = 1.87, P = 0.000) and drinking contaminated water from pond (OR = 1.77, P = 0.003).


CONCLUSIONS
The main risk factors for PLC in China are liver diseases, family history of liver carcinoma, poor psychic status, aflatoxin, and some unhealthy behaviors.
Luo
Rui-Hong
RH
Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China. ruihongluo2002@yahoo.com.cn
Zhao
Zhi-Xin
ZX
Zhou
Xu-Yu
XY
Gao
Zhi-Liang
ZL
Yao
Ji-Lu
JL
D000428:Alcohol Drinking / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005192:Family Health; D005506:Food Contamination; D015438:Health Behavior; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology*; D012307:Risk Factors