[Therapeutic perspectives in ischemic conditions].
Recently the angiogenic mechanism of platelet-derived growth factor-CC was discovered. This factor is capable of mobilize endothelial progenitor cells in ischemic conditions, and induce differentiation of bone marrow cells into endothelial cells. The possibility of modulating the activity of this factor may provide a new strategy for treating ischemic diseases.
Rossi
Giuliano
G
Primario Medico f.r., Ospedale San Filippo Neri, Roma.
D000818:Animals; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D017202:Myocardial Ischemia / Q000188:drug therapy; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D042461:Vascular Endothelial Growth Factor A / Q000187:drug effects
D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A