title: Warfarin-induced leukocytoclastic vasculitis.
abstract: Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy.
authors.affiliation: Ambulatory Care Pharmacy, University of Southern California School of Pharmacy, Los Angeles, CA 90033, USA.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Yaghoubian
authors.forename: Binh
authors.initials: B
authors.lastname: Ngo
authors.forename: May
authors.initials: M
authors.lastname: Mak
authors.forename: Enrique
authors.initials: E
authors.lastname: Ostrzega
authors.forename: Jane
authors.initials: J
authors.lastname: Tesoro
authors.forename: Gladys H Moriguchi
authors.initials: GH
authors.lastname: Mitani
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin