Tadalafil-associated priapism.
A healthy 46-year-old man presented to the Emergency Department with a 36-hour history of persistent, painful erection after taking the cyclic guanylyl monophosphate-specific phosphodiesterase 5 inhibitor tadalafil. He had no other identified contributing factors for priapism. After confirmation of ischemic priapism and failure of bedside management in the Emergency Department, the patient underwent operative caverno-spongiosal shunting. Postoperatively, the erection initially rebounded but gradually receded with manual compression over 48 hours. At outpatient follow-up, the patient remained flaccid without erections. To our knowledge, this is the first report of tadalafil-associated priapism.
King
Stephen H
SH
Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA. shking@u.washington.edu
Hallock
Maralyn
M
Strote
Jared
J
Wessells
Hunter
H
D000328:Adult; D002243:Carbolines / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D011317:Priapism / Q000139:chemically induced*; D000068581:Tadalafil
D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil