Severe cytomegalovirus enterocolitis after standard chemotherapy for non-Hodgkin's lymphoma.
Reports of cytomegalovirus (CMV) colitis mainly concern patients with immunocompromisation resulting from, among others, HIV infection, allogeneic bone marrow transplantation and solid organ transplantation. CMV colitis rarely occurs during standard chemotherapy for non-Hodgkin's lymphoma (NHL). An unusual case of CMV enterocolitis in a 62-year-old patient is reported. After a first course of salvage chemotherapy for NHL, diffuse erosions and sloughing mucosa were seen throughout the large bowel. The final diagnosis was based on histological findings. Although ganciclovir and foscarnet are effective for CMV viremia, their use in the treatment of severe diarrhea in our patient did not result in improvement for one week, whereas concomitant use of octreotide led to rapid improvement. Octreotide may therefore be an effective agent for severe colitis.
Nomura
Kenichi
K
Department of Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan. nomuken@koto.kpu-m.ac.jp
Kamitsuji
Yuri
Y
Kono
Eri
E
Matsumoto
Yosuke
Y
Yoshida
Naohisa
N
Konishi
Hideyuki
H
Horiike
Shigeo
S
Okanoue
Takeshi
T
Taniwaki
Masafumi
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D003586:Cytomegalovirus Infections / Q000139:chemically induced* / Q000188:drug therapy; D003907:Dexamethasone / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D004760:Enterocolitis / Q000139:chemically induced* / Q000188:drug therapy / Q000821:virology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use; D014750:Vincristine / Q000009:adverse effects
D005765:Gastrointestinal Agents; D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D015282:Octreotide