Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice.
In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.
Pultz
Nicole J
NJ
Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, 10701 East Blvd., Cleveland, OH 44106, USA.
Donskey
Curtis J
CJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000254:growth & development; D001427:Bacterial Toxins / Q000378:metabolism*; D002432:Cecum / Q000382:microbiology*; D016360:Clostridioides difficile / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D004768:Enterotoxins / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D004768:Enterotoxins