title: Evaluation of bilateral cingulum with tractography in patients with Alzheimer's disease.
abstract: A fiber-tracking algorithm was used to extract fractional anisotropy of bilateral cingulum bundles in patients with probable Alzheimer's disease and normal aging controls. In addition, their hippocampal volumes were measured manually. Relative to normal controls, Alzheimer's disease patients showed a significant reduction of fractional anisotropy and hippocampal volumes. Significant correlation was observed between fractional anisotropy values and volumes of hippocampi and mini-mental state examination scores. This study suggests that lower anisotropy of cingulum bundles is associated with cognitive dysfunction and atrophy of the limbic system.
authors.affiliation: Department of Radiology, Peking University First Hospital, Beijing 100034, PR China. ouyangxu2004@vip.sina.com
authors.forename: Sheng
authors.initials: S
authors.lastname: Xie
authors.forename: Jiang Xi
authors.initials: JX
authors.lastname: Xiao
authors.forename: Yin Hua
authors.initials: YH
authors.lastname: Wang
authors.forename: Hong Kun
authors.initials: HK
authors.lastname: Wu
authors.forename: Gao Lang
authors.initials: GL
authors.lastname: Gong
authors.forename: Xue Xiang
authors.initials: XX
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000544:Alzheimer Disease / Q000473:pathology*; D016880:Anisotropy; D001284:Atrophy / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D013223:Statistics as Topic