Topiramate and severe metabolic acidosis: case report.
Topiramate infrequently induces anion gap metabolic acidosis through carbonic anhydrase inhibition on the distal tubule of the nephron--a type 2 renal tubular acidosis. We report on a 40 years old woman previously healthy that developed significant asymptomatic metabolic acidosis during topiramate therapy at a dosage of 100 mg/day for three months. Stopping medication was followed by normalization of the acid-base status within five weeks. This infrequent side effect appears unpredictable and should be given careful attention.
Burmeister
Jayme E
JE
Serviços de Clínica Médica e de Nefrologia, Hospital Luterano. burmeister@via-rs.net
Pereira
Rafael R
RR
Hartke
Elisa M
EM
Kreuz
Michele
M
D000141:Acidosis, Renal Tubular / Q000139:chemically induced* / Q000175:diagnosis; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008875:Middle Aged; D000077236:Topiramate
D002257:Carbonic Anhydrase Inhibitors; D000077236:Topiramate; D005632:Fructose