title: Fruit acids do not enhance sodium lauryl sulphate-induced cumulative irritant contact dermatitis in vivo.
abstract: Combined exposure to different irritants in the workplace may lead to irritant contact dermatitis, which is the main type of occupational dermatitis among bakers and confectioners. Following previous work on "tandem irritation", a panel of healthy volunteers was exposed twice daily for 4 days to the organic fruit acids: citric, malic, and lactic acid, either alone or in tandem application with 0.5% sodium lauryl sulphate (SLS) in a repetitive irritation test. Irritant cutaneous reactions were quantified by visual scoring and non-invasive measurement of transepidermal water loss and skin colour reflectance. Twice daily application of either citric or malic acid alone did not induce a significant irritant reaction. Combined exposure to one of the fruit acids and SLS caused marked barrier disturbance, but the latter irritant effect was smaller than that obtained by combined exposure to SLS and water. Thus, combined exposure to the above-mentioned fruit acids and SLS did not enhance cumulative skin irritation.
authors.affiliation: Department of Dermatology, Friedrich-Schiller-University, Erfurter Strasse 35, DE-07740 Jena, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Schliemann-Willers
authors.forename: Silke
authors.initials: S
authors.lastname: Fuchs
authors.forename: Peter
authors.initials: P
authors.lastname: Kleesz
authors.forename: Romano
authors.initials: R
authors.lastname: Grieshaber
authors.forename: Peter
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000328:Adult; D019343:Citric Acid; D002957:Citrus; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology; D004347:Drug Interactions; D005260:Female; D019649:Food Industry; D005638:Fruit; D006801:Humans; D007509:Irritants; D019344:Lactic Acid; D008293:Malates; D008297:Male; D011237:Predictive Value of Tests; D016037:Single-Blind Method; D012882:Skin Tests; D012967:Sodium Dodecyl Sulfate; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D007509:Irritants; D008293:Malates; D019343:Citric Acid; D019344:Lactic Acid; D012967:Sodium Dodecyl Sulfate; C030298:malic acid