1,4-benzoxazin-3-one, 2-benzoxazolinone and gallic acid from Calceolaria thyrsiflora Graham and their antibacterial activity.
Secondary metabolites, DIBOA, HBOA, 7-OH-HBOA, BOA and gallic acid, were isolated and quantified from Calceolaria thyrsiflora Graham, a native medicinal plant of Chile belonging to the Scrophulariaceae family. The highest DIBOA contents were determined in leaves (145 mmol kg(-1) dry wt) and flowers (161 mmol kg(-1) dry wt). Antibacterial activities of DIBOA, HBOA, BOA, gallic acid and infusions of flowers and leaves were determined. The phytomedicinal properties attributed to C. thyrsiflora Graham could be understood on the basis of its antibacterial activity.
Bravo
Héctor R
HR
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla, Santiago, Chile. scopaja@uchile.cl
Copaja
Sylvia V
SV
Figueroa-Duarte
Sebastián
S
Lamborot
Madeleine
M
San Martín
José
J
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D048588:Benzoxazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001583:Benzoxazoles / Q000737:chemistry* / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D005707:Gallic Acid / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D028083:Scrophulariaceae / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
C436752:2-hydroxy-1,4-benzoxazin-3-one; D000900:Anti-Bacterial Agents; D048588:Benzoxazines; D001583:Benzoxazoles; D010078:Oxazines; C017057:benzoxazolone; C104846:2,4-dihydroxy-1,4-benzoxazin-3-one; D005707:Gallic Acid