title: Synthesis, gas-phase photoelectron spectroscopic, and theoretical studies of stannylated dinuclear iron dithiolates.
abstract: Stannylated dinuclear iron dithiolates (mu-SSnMe(2)CH(2)S)[Fe(CO)(3)](2), (mu-SCH(2)SnMe(2)CH(2)S) [Fe(CO)(3)](2), and (mu-SCH(2)SnMe(3))(2)[Fe(CO)(3)](2), which are structurally similar to the active site of iron-only hydrogenase, were synthesized and studied by gas-phase photoelectron spectroscopy. The orbital origins of ionizations were assigned by comparison of He I and He II photoelectron spectra and with the aid of hybrid density functional electronic structure calculations. Stannylation lowers the ionization energy of sulfur lone pair orbitals in these systems owing to a geometry-dependent interaction. The Fe-Fe sigma bond, which is the HOMO in all these systems, is also substantially destabilized by stannylation due to a previously unrecognized geometry-dependent interaction between axial sulfur lone pair orbitals and the Fe-Fe sigma bond. Since cleaving the Fe-Fe sigma bond is a key step in the mechanism of action of iron-only hydrogenase, these newly recognized geometry-dependent interactions may be utilized in designing biologically inspired hydrogenase catalysts.
authors.affiliation: Department of Chemistry, The University of Arizona, Tucson, 85721, USA. rglass@u.arizona.edu
authors.forename: Richard S
authors.initials: RS
authors.lastname: Glass
authors.forename: Nadine E
authors.initials: NE
authors.lastname: Gruhn
authors.forename: Edward
authors.initials: E
authors.lastname: Lorance
authors.forename: Maya S
authors.initials: MS
authors.lastname: Singh
authors.forename: Nhu Y T
authors.initials: NY
authors.lastname: Stessman
authors.forename: Uzma I
authors.initials: UI
authors.lastname: Zakai
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D006864:Hydrogenase / Q000737:chemistry* / Q000378:metabolism; D007506:Iron-Sulfur Proteins / Q000737:chemistry* / Q000378:metabolism; D008962:Models, Theoretical; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013816:Thermodynamics; D014001:Tin / Q000737:chemistry*
chemical_list: D007506:Iron-Sulfur Proteins; D009942:Organometallic Compounds; D014001:Tin; C118830:iron hydrogenase; D006864:Hydrogenase