Genetic polymorphisms and risk of recurrent deep venous thrombosis in young people: prospective cohort study.
OBJECTIVE
To determine the incidence of deep venous thrombosis (DVT) recurrence in young people, and its association with some genetic polymorphisms (FV G1691A, FII G20210A, MTHFR C677T, PAI-1 4G/5G).


METHODS
Prospective cohort study.


METHODS
A database was established prospectively to follow-up a cohort of unselected patients who had had a first episode of objectively proven DVT under the age of 40 years. All patients had DNA analysis for heritable thrombophilia. We excluded patients with deficiency of antithrombin, protein C or protein S, malignant disease, antiphospholipid syndrome, or a requirement for long-term antithrombotic treatment. The end-point was objective evidence of symptomatic DVT recurrence.


RESULTS
Eighty-seven patients were enrolled in the study. Mean duration of follow-up was 4.07 years. At 2 years, the cumulative recurrence rate was 19.3%. The risk of risk was not related to presence or absence of laboratory evidence of genetic polymorphisms: FV G1619A (HR 1.26 [95%CI: 0.64-2.46]; p = 0.51), FII G20210A (HR 0.81 [95%CI: 0.35-1.89]; p = 0.62), MTHFR C677T (HR 1.26 [95%CI: 0.56-2.81]; p = 0.58), PAI-1 4G/5G (0.84 [95%CI: 0.35-2.05]; p = 0.71).


CONCLUSIONS
In this study, the risk of recurrent deep venous thrombosis in young people was not related with the presence of FV G1691A, FII G20210A, MTHFR C677T or PAI-1 4G/5G polymorphisms.
Mansilha
A
A
Department of Vascular Surgery, S. João University Hospital, Porto, Portugal. mansilha@netcabo.pt
Araújo
F
F
Severo
M
M
Sampaio
S M
SM
Toledo
T
T
Albuquerque
R
R
D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2) / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001779:Blood Coagulation Factors / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012008:Recurrence; D020246:Venous Thrombosis / Q000235:genetics*
D001779:Blood Coagulation Factors; D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2)