title: Lack of impact of ABO blood group or corresponding isoantibodies on the immune response after rabies vaccination.
abstract: Demand for rabies hyperimmunoglobulin has increased recently, requiring optimization of vaccination schemes for immunized plasma donors. Possible resemblance of rabies vaccine to blood group antigens and consequential association of the immune response to rabies vaccine and blood group or corresponding isoantibodies has not yet been investigated. We analyzed antirabies antibodies after rabies vaccination and ABO blood group in 142 individuals, and isoantibody titers in 92 of those individuals. We did not find any correlation of the immune response with blood group or isoantibody levels. There was also no correlation with the sex of individuals, but there was a weak correlation between age and rabies-specific antibody level. Rabies vaccination schemes for immunized donors cannot be optimized on the basis of blood groups or isoantibody titers.
authors.affiliation: University Clinic for Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria. christoph.buchta@meduniwien.ac.at
authors.forename: Christoph
authors.initials: C
authors.lastname: Buchta
authors.forename: Günther
authors.initials: G
authors.lastname: Körmöczi
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Rainer
authors.initials: R
authors.lastname: Puhr
authors.forename: Marion
authors.initials: M
authors.lastname: Kompatscher
authors.forename: Gerhard
authors.initials: G
authors.lastname: Jüngling
authors.forename: Jana
authors.initials: J
authors.lastname: List
authors.forename: Maria
authors.initials: M
authors.lastname: Macher
authors.forename: Paul
authors.initials: P
authors.lastname: Höcker
authors.forename: Thomas
authors.initials: T
authors.lastname: Watkins-Riedel
authors.forename: Markus
authors.initials: M
authors.lastname: Dettke
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D000918:Antibody Specificity / Q000276:immunology; D001317:Austria; D001782:Blood Donors; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology; D013223:Statistics as Topic
chemical_list: D000017:ABO Blood-Group System; D007518:Isoantibodies; D011819:Rabies Vaccines