title: Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome.
abstract: The best characterised properties of human interferon, its antiviral (AV) and cell multiplication inhibitory (CMI) activities, are controlled, in an unexplained manner, by genes on chromosomes 21 (refs 1-4; 14-16). Human and animal interferons have various immunosuppressive effects, among them the inhibition in vitro of DNA synthesis in activated lymphocytes. Using mitogen- and antigen-stimulated lymphocytes from normal subjects (disomic 21) and others with Down's syndrome (trisomic 21), we have found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons. We suggest that this property is also regulated by genes on chromosome 21.
authors.affiliation: Department of Medical Biochemistry and Pediatrics, University of Calgary, Alberta, Canada.
authors.forename: C G
authors.initials: CG
authors.lastname: Cupples
authors.forename: Y H
authors.initials: YH
authors.lastname: Tan
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004247:DNA / Q000032:analysis / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects; D004314:Down Syndrome / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology / Q000494:pharmacology; D007372:Interferons / Q000276:immunology / Q000494:pharmacology*; D007621:Karyotyping; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D004247:DNA; D007372:Interferons