Are factor V and prothrombin mutations associated with increased risk of oral cancer?
BACKGROUND
Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore, a search for a similar association of other thrombosis-related factors with oral cancer is justified.


METHODS
In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy controls.


RESULTS
Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia (p < 0.001).


CONCLUSIONS
There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in oncogenesis in the oral region.
Vairaktaris
Eleftherios
E
Department of Maxillofacial Surgery, University of Athens Medical School, Vas. Sofias 93 & Dim. Soutsou 1, Athens, Greece.
Yapijakis
Christos
C
Wiltfang
Jörg
J
Ries
Jutta
J
Vylliotis
Antonis
A
Derka
Spyridoula
S
Vasiliou
Stavros
S
Neukam
Friedrich W
FW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000097:blood / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin