Secondary diabetes mellitus: late complication of glycogen storage disease type 1b.
We report a 22 year-old male with glycogen storage disease type 1 (GSD-1) who developed diabetes mellitus secondary to pancreatic islet beta-cell insufficiency. Diabetes mellitus should be considered among the late complications of GSD-1. The pathogenesis of the conversion, from a disease characterized by hypoglycemia to a disease dominated by hyperglycemia, is discussed.
Spiegel
Ronen
R
Department of Pediatrics A, HaEmek Medical Center, Afula 18101, Israel. spiegelr@zahav.net.il
Rakover-Tenenbaum
Yardena
Y
Mandel
Hanna
H
Lumelski
Dmitry
D
Admoni
Osnat
O
Horovitz
Yoseph
Y
D000328:Adult; D003920:Diabetes Mellitus / Q000209:etiology* / Q000473:pathology; D005953:Glycogen Storage Disease Type I / Q000150:complications* / Q000473:pathology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007515:Islets of Langerhans / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000000981:diagnostic imaging; D010186:Pancreatic Function Tests; D014057:Tomography, X-Ray Computed