[Thymodepressin protects murine bone marrow CFU-S from the hyperthermic damage].
Was studied the influence of the Thymodepressin (dipeptide D-iEW--a new Russian immuno- and haemodepressant), on the hyperthermic sensitivity of haemopoietic precursors (CFU-S) and tumor model cells (EL-4 and Rauscher leukaemia). It was determined, that the injection of the Thymodepressin to donor mice, or the incubation with the preparation of the marrowy cells of normal mice provides the increasing of the CFU-S resistance to the following heating (43 degrees C). On the contrary, Thymodepressin-treated tumor cells became even more heat-sensitive. The data show that Thymodepressin can be useful for protection the haemopoietic precursors not only from radiation and chemotherapy, as it was shown earlier, but also from the hyperthermy.
Semenets
T N
TN
Semina
O V
OV
Deĭgin
V I
VI
Maliutina
Ia V
IaV
Saenko
A S
AS
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006358:Hot Temperature; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D010455:Peptides / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology
D010455:Peptides; D020011:Protective Agents; C449663:thymodepressin