Effect of chronic intake of sweet substance on nociceptive thresholds and feeding behavior of Rattus norvegicus (Rodentia, Muridae).
The investigation of the influence of sweetened food on feeding behavior targeted to non-sucrose nutrients as well as the sensitivity to painful stimuli in isolated and grouped animals is the aim of the present work. The tail withdrawal latencies in the tail-flick test (a spinal reflex) were measured before and immediately after the treatment with tap water or sucrose (62, 125 or 250 g/l). Our findings suggest that: (a) The analgesic effect of sucrose intake depends on the concentration of sucrose solution and on the time during which the solution is consumed; (b) the most effective concentration of sucrose followed by antinociceptive effect was the one of 250 g/l in both isolated and grouped animals; (c) considering the individually caged rats, the intake of sucrose in the highest concentration (250 g/l) was the smallest as compared with the consumption of sucrose in more diluted solutions (62.5 and 125 g/l), but this higher sweetened solution was followed by antinociception; (d) animals treated with concentrated sucrose solution ate smaller quantities of pellets than animals treated with tap water; (e) tonic intake of highly concentrated sweet substance seems to be crucial for the increase of the nociceptive threshold in our model of sweet substance-induced antinociception.
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Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, School of Medicine of Ribeirão Preto of the University of São Paulo (FMRP-USP), Avenue of Bandeirantes, 3900, Ribeirão Preto (SP) 14049-900, Brazil.
Rebouças
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EC
Freitas
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RL
Caires
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MP
Cardoso
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Resende
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Shimizu-Bassi
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Elias-Filho
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Coimbra
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D000698:Analgesia; D000818:Animals; D019422:Dietary Sucrose / Q000008:administration & dosage*; D004326:Drinking; D004435:Eating / Q000187:drug effects*; D008297:Male; D009619:Nociceptors / Q000502:physiology; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D013623:Tail; D013997:Time Factors
D019422:Dietary Sucrose; D012996:Solutions