title: Monocyte chemoattractant protein-1 level in serum of patients with acute spinal cord injury.
abstract: OBJECTIVE
  To detect the concentration of monocyte chemoattractant protein-1 (MCP-1) in the serum of patients with incomplete spinal cord injury and evaluate its relation with the pathologic classification of the spinal cord injury.
  
  
  METHODS
  MCP-1 concentration in the serum of patients with incomplete spinal cord injury (iSCI), single spine compression and healthy subjects were detected by ELISA, respectively in the present study and the magnetic resonance imaging data of these patients were studied at the same time on a blind base.
  
  
  RESULTS
  Serum level of MCP-1 in iSCI patients was 428 pg/ml +/- 11 pg/ml by ELISA, which was higher than both that of the patients with single spine compression and of controls, with the concentration of 184 pg/ml +/- 21 pg/ml and 124 pg/ml +/- 15 pg/ml, respectively. There was significant difference between any two groups (P < 0.01). iSCI patients with normal MRI showed a lower serum level of MCP-1 as 312 pg/ml+/- 30 pg/ml. Pathological classification of spinal cord edema and hematoma corresponded to 390 pg/ml +/- 16 pg/ml and 508 pg/ml+/- 24 pg/ml in the concentration of MCP-1.
  
  
  CONCLUSIONS
  MCP-1 may induce secondary inflammatory response by recruiting inflammatory cells to the injury site and thus affect the prognosis of spinal cord injury.
authors.affiliation: Deparment of Orthopaedics of Renmin Hospital, Wuhan University, China. martin1354@163.com
authors.forename: Shi-qing
authors.initials: SQ
authors.lastname: Liu
authors.forename: Yong-gang
authors.initials: YG
authors.lastname: Ma
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.forename: Li
authors.initials: L
authors.lastname: Fan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000097:blood* / Q000473:pathology
chemical_list: D018932:Chemokine CCL2