Decoding Tat: the biology of HIV Tat posttranslational modifications.
The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed.
Hetzer
Claudia
C
Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Dormeyer
Wilma
W
Schnölzer
Martina
M
Ott
Melanie
M
D001120:Arginine / Q000378:metabolism; D015696:Gene Products, tat / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus; D001120:Arginine