title: Assessment of potential application of binary mixtures of 2,4-d with novel aminophosphonates.
abstract: A series of new aminoalkane- and aminofluorenephosphonates was synthesized for agrochemical application. The particular compounds had different alkyl substituents at the carbon, nitrogen and phosphorus atoms. Their pesticidal activity was checked by applying various experimental methods. These included the measurements of compounds' potency: to inhibit growth of cucumber and germination of white mustard seeds, to influence on the membrane potential of algae and to damage human erythrocyte membranes resulting in hemolysis. All the aminophosphonates were also used in equimolar binary mixtures with the well-known herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), to check, if using such mixtures, the biological efficiencies found for particular compounds could be enhanced due to interactions between aminophosphonates and 2,4-D. The results demonstrated, that depending on the structural features of the compounds, the final effects differed from antagonistic, through additive to the most promising synergistic ones. However, the type of interaction between 2,4-D and the compounds studied found in different experiments was somewhat different. In order to estimate those effects various statistical methods were used (toxic unit method, isobole method).
authors.affiliation: Department of Physics and Biophysics, Agricultural University, Norwida, Poland. js@ozi.ar.wroc.pl
authors.forename: Janusz
authors.initials: J
authors.lastname: Sarapuk
authors.forename: Halina
authors.initials: H
authors.lastname: Klesczyńska
authors.forename: Dorota
authors.initials: D
authors.lastname: Bonarska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bielecki
authors.forename: Zenon
authors.initials: Z
authors.lastname: Trela
authors.forename: Leszek
authors.initials: L
authors.lastname: Kordas
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D018553:Cucumis sativus / Q000187:drug effects*; D004338:Drug Combinations; D005449:Fluorenes / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D063065:Organophosphonates / Q000494:pharmacology*; D010575:Pesticides / Q000138:chemical synthesis* / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D005449:Fluorenes; D006540:Herbicides; D063065:Organophosphonates; D010575:Pesticides; D011437:Propylamines; D015084:2,4-Dichlorophenoxyacetic Acid