title: Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction.
abstract: The effect of edaravone as an inhibitor of ischemic brain damage in addition to routine treatment was retrospectively examined in 70 patients with lacunar infarction who were admitted within 24 hours of symptom onset. Clinical status was assessed using the National Institutes of Health Stroke Scale (NIHSS). The modified Rankin Scale (MRS) was used to assess clinical outcomes at 3 months after onset, with a good outcome defined as MRS score < or =2. Risk factors were also evaluated, including evidence of hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, and a history of smoking longer than 2 months. The probability of a good outcome and independence at 3 months was assessed by backward stepwise logistic regression analysis based on the maximum likelihood ratio. Administration of edaravone yielded an odds ratio with multivariate adjustment of 6.49 (95% confidence interval, 1.35 to 50.32; p < 0.05) for a good outcome at 3 months. Higher baseline NIHSS score and higher age also adversely affected the outcome at 3 months (p < 0.005). Administration of edaravone improves the outcome of patients with lacunar infarction.
authors.affiliation: The Department of Neurology, Neurological Institute, Nippon Medical School Chiba-Hokusoh Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mishina
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Komaba
authors.forename: Shiro
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Shushi
authors.initials: S
authors.lastname: Kominami
authors.forename: Takaharu
authors.initials: T
authors.lastname: Fukuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Mizunari
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000208:Acute Disease; D000368:Aged; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D020520:Brain Infarction / Q000188:drug therapy* / Q000503:physiopathology; D000077553:Edaravone; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine