title: Time to diagnosis of intraspinal tumors.
abstract: The aim of this study was to assess the time to diagnosis in patients with intraspinal tumors and to assess factors contributing to a long delay in some patients. Patients who were admitted at our hospital over a 15-year period (1986-2000) with an intraspinal (either intradural or extradural) tumor were included. Records of patients were studied for variables such as sex, age, diagnosis, date of diagnosis, initial symptoms, symptoms at diagnosis, level of tumor, original diagnosis and diagnostic technique [CT-myelography, CT-caudography or magnetic resonance imaging (MRI)]. The median time to diagnosis of 108 patients with an intraspinal tumor was 12.3 months (range: 4 days-14.4 years). Most common initial symptoms were back and/or neck pain, pain radiating to one extremity and walking disturbances. There was no distinctive clinical pattern between intramedullary and extramedullary tumors regarding initial symptoms. At the time of diagnosis, patients presented with moderate to severe neurological deficits: weakness in one extremity in 26%, sphincter disturbance (20%) and paraparesis (12%). Improved imaging of the spinal cord by MRI did not result in earlier detection of the intraspinal tumor. The time to diagnosis is explained by non-specific and slowly progressing signs and symptoms. A high rate of clinical suspicion should be present to diagnose an intraspinal tumor at an early stage.
authors.affiliation: Department of Neurology, St Elisabeth Hospital, Tilburg, The Netherlands. k.jellema@elisabeth.nl
authors.forename: K
authors.initials: K
authors.lastname: Jellema
authors.forename: J J
authors.initials: JJ
authors.lastname: Overbeeke
authors.forename: H L J M
authors.initials: HL
authors.lastname: Teepen
authors.forename: L H
authors.initials: LH
authors.lastname: Visser
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D013125:Spinal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed / Q000379:methods