Reactions of peroxynitrite with globin proteins and their possible physiological role.
It is now widely accepted that, besides their well-established function in O(2) transport, hemoglobin and myoglobin also undergo several redox reactions aimed to scavenge toxic free radicals and reactive oxygen and nitrogen species. At least some of these reactions are believed to play an important physiological role in the defense against oxidative stress. This aspect is exemplified by the recently discovered neuroglobin, a globin expressed in the brain. Rather than being considerably involved in reversible O(2) binding, neuroglobin is likely to undergo redox reactions to protect neurons against oxidative and potentially pathogenic pathways, as those operating after episodes of tissue hypoxia or ischemia. A major part of the cellular damage occurring under such conditions has been ascribed to formation of peroxynitrite, that originates from the reaction between two biologically important free radicals, nitric oxide (NO ) and superoxide. Here we review the current knowledge of the reactions of different forms of hemoglobin, myoglobin, and neuroglobin with peroxynitrite and discuss their physiological role on the basis of measured rate constants and on the probability of occurrence of these reactions in vivo.
Herold
Susanna
S
Laboratorium für Anorganische Chemie, Eidgenössische Technische Hochschule, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
Fago
Angela
A
D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D005609:Free Radicals; D005914:Globins / Q000737:chemistry* / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry; D006736:Horses; D006801:Humans; D000860:Hypoxia; D007511:Ischemia / Q000473:pathology; D007700:Kinetics; D008956:Models, Chemical; D009211:Myoglobin / Q000737:chemistry; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism; D000078787:Neuroglobin; D009569:Nitric Oxide / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000737:chemistry / Q000494:pharmacology*; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species
D005609:Free Radicals; D006454:Hemoglobins; D009211:Myoglobin; D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D000255:Adenosine Triphosphate; D005914:Globins; D010100:Oxygen; D002118:Calcium