title: In vivo transfer of plasmid-encoded ACC-1 AmpC from Klebsiella pneumoniae to Escherichia coli in an infant and selection of impermeability to imipenem in K. pneumoniae.
abstract: We describe in vivo selection of a Klebsiella pneumoniae strain with diminished imipenem susceptibility attributable to plasmid-encoded ACC-1 beta-lactamase production and loss of a 36-kDa major outer membrane protein, together with transfer of this plasmid from K. pneumoniae to Escherichia coli in a Tunisian infant.
authors.affiliation: Service de Microbiologie, Hôpital Robert Debré, 48 Bd Sérurier, 75395 Paris cedex 19, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.forename: Béatrice
authors.initials: B
authors.lastname: Burghoffer
authors.forename: Valérie
authors.initials: V
authors.lastname: Gautier
authors.forename: Naïma
authors.initials: N
authors.lastname: Brahimi
authors.forename: Patricia
authors.initials: P
authors.lastname: Mariani-Kurkdjian
authors.forename: Alaa
authors.initials: A
authors.lastname: El-Ghoneimi
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Guillaume
authors.initials: G
authors.lastname: Arlet
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics*; D003227:Conjugation, Genetic; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007223:Infant; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D008297:Male; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D012641:Selection, Genetic; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D015378:Imipenem; C048795:AmpC beta-lactamases; D001618:beta-Lactamases