Androgens and cognitive function.
Decrements in cognitive functioning are a common complaint among men with late-onset hypogonadism (LOH). This article reviews the neurobiologic connection between gonadal steroids and cognitive functions, developmental effects and activational effects throughout the lifespan. Studies of hormone replacement therapy in older men are reviewed as well as epidemiological studies of endogenous hormones and cognition. While many studies of Androgen Replacement Therapy (ART) in older men suggest a potential beneficial effect on cognition, most studies to date have been small and need further replication with larger sample sizes.
Cherrier
M M
MM
Department of Psychiatry and Behavioral Sciences, University of Washington, School of Medicine and Veterans Administration Puget Sound Health Care System, Seattle 98108, USA. cherrier@u.washington.edu
D000368:Aged; D000375:Aging; D000728:Androgens / Q000008:administration & dosage / Q000172:deficiency / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000188:drug therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000502:physiology
D000728:Androgens; D013739:Testosterone