Effects of selegiline alone or with donepezil on memory impairment in rats.
Selegiline, a monoamine oxidase-B inhibitor, is reported to improve memory and learning in dementia of Alzheimer's type. However, only a few studies have reported its use in animal models. Here, we evaluated the effects of selegiline only or its combined use with donepezil, a selective acetylcholinesterase inhibitor on memory impairment, using a Morris water maze. Selegiline dose-dependently attenuated ethylcholine aziridinium ion-induced memory impairment. Co-administration of selegiline and donepezil, at doses that do not exert efficacy individually, significantly ameliorated scopolamine+p-chlorophenylalanine-induced memory deficits. These results suggest that selegiline improves memory impairment mediated by the cholinergic system, and provide evidence of the usefulness of co-treatment with selegiline and donepezil for treating spatial deficits in dementia.
Takahata
Kazue
K
Research Institute, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka 580-0011, Japan.
Minami
Akiko
A
Kusumoto
Haruko
H
Shimazu
Seiichiro
S
Yoneda
Fumio
F
D000704:Analysis of Variance; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D001388:Aziridines / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D000077265:Donepezil; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004924:Escape Reaction / Q000187:drug effects; D010134:Fenclonine / Q000633:toxicity; D007189:Indans / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000633:toxicity; D012642:Selegiline / Q000494:pharmacology*; D013997:Time Factors
D000978:Antiparkinson Agents; D001388:Aziridines; D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D012642:Selegiline; D000077265:Donepezil; C044894:ethylcholine aziridinium; D012601:Scopolamine; D002794:Choline; D010134:Fenclonine