title: [Effect of hypoxia on the expression of urokinase-type plasminogen activator in human tongue squamous cell carcinoma cells (Tca8113)].
abstract: OBJECTIVE
  To observe the expression of urokinase-type plasminogen activator (uPA) in human tongue squamous carcinoma cells (Tca8113) under hypoxia, in order to explore the relation between hypoxia and invasion and metastasis of oral cancer.
  
  
  METHODS
  Under different hypoxic times(0, 3, 6, 12, 24 h), the expression of uPA protein was examined quantitatively using immunohistochemical technique (IH) and flow cytometry (FCM).
  
  
  RESULTS
  Hypoxia promoted the expression of uPA. The longer hypoxic time was, the higher expression of uPA was.
  
  
  CONCLUSIONS
  Hypoxia can promote invasion and metastasis of oral squamous carcinoma through stimulating the expression of uPA.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
authors.forename: Sheng-Zhi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Liang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Cheng
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Bi
authors.forename: Zu-Yi
authors.initials: ZY
authors.lastname: Mao
authors.forename: Do-Zhang
authors.initials: DZ
authors.lastname: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell; D006801:Humans; D009062:Mouth Neoplasms; D009361:Neoplasm Invasiveness; D014062:Tongue Neoplasms; D014568:Urokinase-Type Plasminogen Activator
chemical_list: D014568:Urokinase-Type Plasminogen Activator