title: In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.
abstract: The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates.
authors.affiliation: Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas-Houston Medical School, 6431 Fannin, MSB 2.112, Houston, TX 77030, USA.
authors.forename: Annie
authors.initials: A
authors.lastname: Philip
authors.forename: Zekaver
authors.initials: Z
authors.lastname: Odabasi
authors.forename: Jose
authors.initials: J
authors.lastname: Rodriguez
authors.forename: Victor L
authors.initials: VL
authors.lastname: Paetznick
authors.forename: Enuo
authors.initials: E
authors.lastname: Chen
authors.forename: John H
authors.initials: JH
authors.lastname: Rex
authors.forename: Luis
authors.initials: L
authors.lastname: Ostrosky-Zeichner
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000145:classification / Q000187:drug effects*; D004357:Drug Synergism; D054714:Echinocandins; D005670:Fusarium / Q000145:classification / Q000187:drug effects*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D000077612:Anidulafungin; D065819:Voriconazole