Successful treatment of a patient with synchronous advanced non-small cell lung cancer and acute myeloid leukemia by a combination of gefitinib, low-dose cytarabine and aclarubicin.
There are few reports describing simultaneous occurrence of acute leukemia and lung cancer. We describe here an 83-year-old woman who simultaneously developed advanced adenocarcinoma of the lung and acute myeloid leukemia. She could not receive intensive chemotherapy due to poor performance status. This patient was treated with a combination of gefitinib, low-dose cytarabine and aclarubicin. This combination could be safely administered in the elderly patient with poor performance status and was effective for both lung cancer and acute myeloid leukemia.
Takigawa
Nagio
N
Department of Pulmonary Medicine, National Hospital Organization, Minarmi-Okayama Medical Center, 4066 Hayashima, Okayama 701-0304, Japan. takigawan@s-okayama.hosp.go.jp
Takeuchi
Makoto
M
Shibayama
Takuo
T
Yoshida
Isao
I
Kawata
Noriko
N
Tada
Atsuhiko
A
Ueoka
Hiroshi
H
Takahashi
Kiyoshi
K
D015250:Aclarubicin / Q000008:administration & dosage; D000208:Acute Disease; D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D016330:Frail Elderly; D000077156:Gefitinib; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy*; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D011799:Quinazolines / Q000008:administration & dosage
D011799:Quinazolines; D003561:Cytarabine; D015250:Aclarubicin; D000077156:Gefitinib