title: Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica.
abstract: Bioassay-directed fractionation of the EtOAc extract of Kadsura japonica has led to the isolation of six new C18 dibenzocyclooctadiene lignans, schizanrins I, J, K, L, M, N, along with four known C19 homolignans, taiwanschirins A, B, C, and heteroclitin F. The elucidations of the new structures were based on spectral analysis. Bioassay evaluation against human type B hepatitis revealed that taiwanschirins A and B showed strong activity for anti-HBsAg and a medium effect for anti-HBeAg at 25 microg/mL (12.9 and 11.9 microM for taiwanschirins A and B, respectively).
authors.affiliation: National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C.
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Ming-Der
authors.initials: MD
authors.lastname: Wu
authors.forename: Ray-Ling
authors.initials: RL
authors.lastname: Huang
authors.forename: Li-Ming Yang
authors.initials: LM
authors.lastname: Kuo
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Hsu
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Chia-Cheng
authors.initials: CC
authors.lastname: Hung
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Chi-Wi
authors.initials: CW
authors.lastname: Ong
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D034242:Cyclooctanes / Q000737:chemistry / Q000494:pharmacology; D006509:Hepatitis B / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000187:drug effects*; D006513:Hepatitis B e Antigens / Q000187:drug effects*; D006801:Humans; D032135:Kadsura; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D034242:Cyclooctanes; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017705:Lignans; D010936:Plant Extracts