title: Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population.
abstract: Disrupted-in-Schizophrenia-1 (DISC1), identified by cytogenetic approaches in a pedigree with familial psychosis, is considered a candidate susceptibility gene for schizophrenia in some populations. In the pedigree, the TRAX gene, located adjacent to DISC1 on the disrupted chromosome 1, may also contribute to the pathophysiology of the familial schizophrenia. We studied association of the DISC1 and TRAX genes with schizophrenia in 338 Japanese by analyzing 15 single nucleotide polymorphisms (SNPs), including 12 SNPs in DISC1 and three in TRAX, respectively. No significant difference was observed between the patients and controls in allelic frequencies or genotypic distributions of 15 SNPs. A weak trend for the association in genotypic distribution of one SNP in TRAX (major homo/hetero/minor homo: 0.324/0.431/0.245 vs. 0.293/0.526/0.181 for patients vs controls, p = 0.039 in the 2 x 3 comparison) turned out to be insignificant after Bonferroni correction. Haplotype analysis did not support the association between the patients and controls. The present study suggests that the DISC1/TRAX locus may not have a major role in Japanese schizophrenia.
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655 Japan.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Maeda
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Akira
authors.initials: A
authors.lastname: Sawa
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002878:Chromosomes, Human, Pair 1; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C412476:DISC1 protein, human; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; C498305:TSNAX protein, human