A model for the interaction of two chemicals.
We describe a method for studying the interaction of two anesthetic agents, Morphine and Midazolam, acting simultaneously in the same individual. Representing the levels of the two chemicals by diffusion processes, we assume their interaction is governed by a linear combination of the separate components. Pharmacological data is used to estimate the model parameters and, in particular, to determine the coefficient in the linear combination. This leads to the conclusion that the two chemicals have a counteractive effect.
Sen
Pali
P
Department of Mathematics and Statistics, University of North Florida, Jacksonville, FL. 32224, USA. psen@unf.edu
Bell
Denis
D
D000777:Anesthetics / Q000494:pharmacology*; D004058:Diffusion; D004347:Drug Interactions; D006801:Humans; D008874:Midazolam / Q000494:pharmacology*; D008954:Models, Biological; D008956:Models, Chemical; D009020:Morphine / Q000494:pharmacology*; D013269:Stochastic Processes
D000777:Anesthetics; D009020:Morphine; D008874:Midazolam