Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy.
OBJECTIVE
Sarcoidosis has been reported to be associated with the HLA genes, in particular DQB1.


METHODS
High resolution DQB 1 of 103 sarcoidosis patients was obtained by sequence-based typing; low resolution HLA-A/B/DRB 1 typing was performed by serological and molecular methods. Small fiber neuropathy (SFN) was established by thermal threshold testing.


RESULTS
Sixty-seven patients suffered from SFN (SFN+), in 36 patients SFN was absent (SFN-). Comparing HLA DQB 1 typings of SFN+ patients, SFN- patients and control individuals revealed a significant increase of the allele DQB 1 0602 in SFN+ patients compared to controls.


CONCLUSIONS
This association might be correlated with a severe course of the disease.
Voorter
Christina E M
CE
Tissue Typing Laboratory, University Hospital Maastricht, The Netherlands.
Drent
Marjolein
M
Hoitsma
Elske
E
Faber
Karin G
KG
van den Berg-Loonen
Ella M
EM
D000328:Adult; D000483:Alleles; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000235:genetics* / Q000276:immunology; D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010641:Phenotype; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications / Q000235:genetics* / Q000276:immunology
D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D004247:DNA