Conjugated polymer-based fluorescence turn-on sensor for nitric oxide.
A turn-on fluorescent sensor for NO (g) in solution was synthesized using a bipyridyl-substituted poly(p-phenylene vinylene) derivative (CP1) as the sensory scaffold. The action of NO (g) upon the CP1-Cu(II) complex reduces it to the CP1-Cu(I) complex with a concomitant 2.8-fold increase in emission intensity. The reagent is selective for NO (g) versus other biological reactive nitrogen species, except for nitroxyl, and has a detection sensitivity limit of 6.3 nM. [structure: see text]
Smith
Rhett C
RC
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tennyson
Andrew G
AG
Lim
Mi Hee
MH
Lippard
Stephen J
SJ
D003300:Copper / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D009569:Nitric Oxide / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D011108:Polymers; D009569:Nitric Oxide; D003300:Copper