title: [Effects of Bromazepam in qEEG by type writing].
abstract: The efficiency with which an information is processed by the brain's neural circuitry can be altered by neuromodulators. The use of Bromazepam in the pharmacological treatment of anxiety disorders is due to its anxiolytic property. However, the effects of this benzodiazepine in motor learning tasks are not entirely understood. In this context, the goal of this study was to assess the effects of Bromazepam (6 mg) on psychophysiological, behavioral, and electrophysiological variables, during the process of learning a motor task. The sample consisted of 26 healthy individuals, of both sexes, between 19 and 36 years of age. The control (placebo) and experimental (Bromazepam 6 mg) groups were submitted to a typewriting task, in a randomized, double-blind design. The results did not reveal differences for phychophysiological and behavioral variables between the groups. Statistical tests pointed out to an interaction between condition and moment, and a hemisphere main effect, i.e. a reduction of relative power in the right hemisphere. This reduction suggests a specialization of the neural circuitry in the hemisphere contralateral to the finger used in the task. Such reduction is independent from the drug administration.
authors.affiliation: Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Dionis
authors.initials: D
authors.lastname: Machado
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Bastos
authors.forename: Marlo
authors.initials: M
authors.lastname: Cunha
authors.forename: Vernon
authors.initials: V
authors.lastname: Furtado
authors.forename: Maurício
authors.initials: M
authors.lastname: Cagy
authors.forename: Roberto
authors.initials: R
authors.lastname: Piedade
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects; D001960:Bromazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D004594:Electrophysiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009048:Motor Skills / Q000187:drug effects* / Q000502:physiology
chemical_list: D014151:Anti-Anxiety Agents; D001960:Bromazepam