title: Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice.
abstract: Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.
authors.affiliation: Departamento de Química Orgânica, Instituto de Química, c.p. 355, CEP 14800-900, UNESP, Araraquara, SP, Brazil.
authors.forename: Marcelo Aparecido
authors.initials: MA
authors.lastname: da Silva
authors.forename: Bruna Paola Murino
authors.initials: BP
authors.lastname: Rafacho
authors.forename: Clelia Akiko
authors.initials: CA
authors.lastname: Hiruma-Lima
authors.forename: Lúcia Regina Machado
authors.initials: LR
authors.lastname: da Rocha
authors.forename: Lourdes Campaner
authors.initials: LC
authors.lastname: dos Santos
authors.forename: Miriam
authors.initials: M
authors.lastname: Sannomiya
authors.forename: Alba Regina Monteiro
authors.initials: AR
authors.lastname: Souza-Brito
authors.forename: Wagner
authors.initials: W
authors.lastname: Vilegas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D031451:Strychnos / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts