title: Synthesis and transdermal penetration of NSAID glycoside esters.
abstract: The glucoside and mannoside derivatives of the NSAIDs flurbiprofen, ibuprofen, ketoprofen and naproxen were synthesised and their penetration through human skin was determined. Experimental transdermal flux data showed that the parent NSAIDs penetrated human skin to a much higher extent than the glycosides.
authors.affiliation: School of Pharmacy, North-West University, Potchefstroom 2520, South Africa.
authors.forename: Henk
authors.initials: H
authors.lastname: Swart
authors.forename: Jaco C
authors.initials: JC
authors.lastname: Breytenbach
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hadgraft
authors.forename: Jeanetta
authors.initials: J
authors.lastname: du Plessis
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D004952:Esters / Q000138:chemical synthesis / Q000493:pharmacokinetics; D005260:Female; D005947:Glucose / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D008358:Mannose / Q000737:chemistry; D000442:Octanols / Q000737:chemistry; D012869:Skin Absorption / Q000502:physiology*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004952:Esters; D006027:Glycosides; D000442:Octanols; D014867:Water; D005947:Glucose; D008358:Mannose