title: [Immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid on perennial allergic rhinitis].
abstract: OBJECTIVE
  To observe the immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with perennial allergic rhinitis.
  
  
  METHODS
  Sixty patients with perennial allergic rhinitis were randomly divided into two groups, 30 in the test group were treated with BCG-PSN plus ketotefen and 30 in the control group were treated with ketotefen respectively. All patients were followed up and assessed for 3 months, and the blood samples were collected before treatment and 3 months after treatment for measuring the blood IgA, IgG, IgM, IgE, CD3, CD4 and CD8.
  
  
  RESULTS
  In the test group, the total effective rate was significantly higher comparable to that in the control group. After treatment of BCG-PSN, blood CD3, CD4 and CD4/CD8 were significantly increased. IgE significantly reduced (P < 0.05).
  
  
  CONCLUSIONS
  BCG polysaccharides nucleic acid can modulate the cellular immunofunction of patients with perennial allergic rhinitis and can increase the curative rate on perennial allergic rhinitis.
authors.affiliation: Department of Otorhinolaryngology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China. tangsiqu@126.com
authors.forename: Siquan
authors.initials: S
authors.lastname: Tang
authors.forename: Bingling
authors.initials: B
authors.lastname: Zhao
authors.forename: Guoyuan
authors.initials: G
authors.lastname: Zhang
authors.forename: Longyue
authors.initials: L
authors.lastname: Liu
authors.forename: Tianming
authors.initials: T
authors.lastname: Zhou
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000737:chemistry*; D009696:Nucleic Acids / Q000627:therapeutic use; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000628:therapy*
chemical_list: D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D011135:Polysaccharides, Bacterial