Crystal structures of aza-beta3-peptides, a new class of foldamers relying on a framework of hydrazinoturns.
Crystals of aza-beta3-peptides have been obtained. This gives the first opportunity for hydrazino peptides, in the sense of oligomers built exclusively with alpha-hydrazinoacetic units, to be observed in the solid state. The structures make it clear that the H-bond network developed by aza-beta3-peptides differs radically from those of the corresponding beta3-peptides but strongly resembles that of the alpha-aminoxy peptides. Our study contributes to the current interest in hydrazino peptides as an extension of the beta-peptide concept.
Salaün
Arnaud
A
SESO, UMR CNRS 6510, Université de Rennes I, and Laboratoire du Solide et Inorganique Moléculaire, UMR CNRS 6511, 263 avenue du General Leclerc CS 74205, 35042 Rennes Cedex, France.
Potel
Michel
M
Roisnel
Thierry
T
Gall
Philippe
P
Le Grel
Philippe
P
D001372:Aza Compounds / Q000737:chemistry* / Q000145:classification*; D018360:Crystallography, X-Ray; D019281:Dimerization; D006834:Hydrazines / Q000737:chemistry* / Q000145:classification*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000145:classification; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
D001372:Aza Compounds; D006834:Hydrazines; D010455:Peptides; C029424:hydrazine