Role for mannose binding lectin in the prevention of Mycoplasma infection.
Polymorphisms in exon 1 of the MBL-2 gene, resulting in reduced plasma levels of mannose binding lectin, were significantly overrepresented in 23 patients with primary antibody deficiency and culture-proven mycoplasma infections (P = 0.0038). This association persisted with the inclusion of a further nine suspected (doxycycline-responsive) cases (P = 0.0087). The lectin was shown to bind to three strains of mycoplasma.
Hamvas
Renata M J
RM
MW Turner, Immunobiology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.
Johnson
Marina
M
Vlieger
Arine M
AM
Ling
Clare
C
Sherriff
Andrea
A
Wade
Angela
A
Klein
Nigel J
NJ
Turner
Malcolm W
MW
Webster
A David B
AD
D005434:Flow Cytometry; D006801:Humans; D037601:Mannose-Binding Lectin / Q000378:metabolism*; D009174:Mycoplasma / Q000378:metabolism; D009175:Mycoplasma Infections / Q000378:metabolism*
D037601:Mannose-Binding Lectin