title: Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma.
abstract: OBJECTIVE
  In order to clarify clinical efficacy of commercially available 5-fluorouracil (5-FU) topical cream, a clinical study was conducted.
  
  
  METHODS
  Two to three cubic millimetres of 5-FU topical cream (Kyowa, Roche) was applied on 50 cases of various types of cholesteatoma (50 patients) two to five times with the interval of 2 weeks, and its clinical efficacy was evaluated by the criteria we developed.
  
  
  RESULTS
  In total, 59% of the cholesteatomas showed good effect, 29% of them showed fair effect, and the effect was poor in the remaining 12%. It was particularly effective in cholesteatomas in the EAC, attic cholesteatomas with an aerated mastoid, and in recurrent-type cholesteatomas.
  
  
  CONCLUSIONS
  5-FU topical cream appeared effective for the treatment of cholesteatomas.
authors.affiliation: Division of Otorhinolaryngology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. htak0831@net.nagasaki-u.ac.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Funabiki
authors.forename: Seishi
authors.initials: S
authors.lastname: Hasebe
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fukuda-Yamamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Kaieda
authors.forename: Tetsu
authors.initials: T
authors.lastname: Iwanaga
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Kumagami
authors.forename: Kenji
authors.initials: K
authors.lastname: Takasaki
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002781:Cholesteatoma / Q000188:drug therapy* / Q000473:pathology; D004427:Ear Diseases / Q000188:drug therapy* / Q000473:pathology; D004431:Ear, External / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil