title: A case of multicentric reticulohistiocytosis with multiple lytic skull lesions.
abstract: Multicentric reticulohistiocytosis (MR) is a rare multisystemic disorder of unknown aetiology characterized by cutaneous and joint manifestations. It is associated with malignancy in up to 31% of cases. Common radiological findings are peri-articular erosions and osteolytic punched-out areas. We present a case of MR with cutaneous nodules, joint pains, and multiple lytic skull lesions--a combination that has not been described before. Osteolytic activity of proinflammatory cytokines (tumour necrosis factor-alpha and interleukin-1) may explain the peri-articular erosions often seen in MR, and the multiple lytic skull lesions seen in our patient.
authors.affiliation: Dermatology Department, Royal London Hospital, and Department of Dermatology, The Middlesex Hospital, London, UK. sgyho@doctors.net.uk
authors.forename: S G Y
authors.initials: SG
authors.lastname: Ho
authors.forename: R C
authors.initials: RC
authors.lastname: Yu
mesh_terms: D000328:Adult; D015616:Histiocytosis, Non-Langerhans-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007592:Joint Diseases / Q000473:pathology; D008297:Male; D011859:Radiography; D012871:Skin Diseases / Q000473:pathology*; D012886:Skull / Q000000981:diagnostic imaging / Q000473:pathology*