title: Antioxidant effects of combined vitamins C and E in acute myocardial infarction. The randomized, double-blind, placebo controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT) trial.
abstract: OBJECTIVE
  There is a large body of evidence that reactive oxygen species (ROS) produced during myocardial ischemia and reperfusion play a crucial role in myocardial damage and endothelial dysfunction. The MIVIT pilot trial was designed to test the effects of antioxidant vitamins C and E on the clinical outcome of patients with AMI.
  
  
  RESULTS
  In this randomized, double-blind, multicenter trial, 800 patients (mean age 62) with AMI were randomly allocated to receive, on top of routine medication, one of two treatments: vitamin C (1000 mg/12 h infusion) followed by 1200 mg/24 h orally and vitamin E (600 mg/24 h) or matching placebo for 30 days. Primary end point (composite of in-hospital cardiac mortality, non-fatal new myocardial infarction, VT/VF/asystole, shock/pulmonary edema) occurred less frequently in patients treated with antioxidants (55 [14%] vs 75 [19%], OR 0.82 [95% CI, 0.68-1.00], p=0.048).
  
  
  CONCLUSIONS
  This randomized pilot trial shows that supplementation with antioxidant vitamins is safe and seems to positively influence the clinical outcome of patients with AMI. A larger study is warranted to provide further evidence of this promising and inexpensive regimen.
authors.affiliation: Postgraduate Medical School, Department of Cardiology, Grochowski Hospital, Warsaw.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jaxa-Chamiec
authors.forename: Bronisław
authors.initials: B
authors.lastname: Bednarz
authors.forename: Dorota
authors.initials: D
authors.lastname: Drozdowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Gessek
authors.forename: Jacek
authors.initials: J
authors.lastname: Gniot
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Janik
authors.forename: Teresa
authors.initials: T
authors.lastname: Kawka-Urbanek
authors.forename: Paweł
authors.initials: P
authors.lastname: Maciejewski
authors.forename: Michał
authors.initials: M
authors.lastname: Ogórek
authors.forename: Michał
authors.initials: M
authors.lastname: Szpajer
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D010865:Pilot Projects; D011044:Poland / Q000453:epidemiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014810:Vitamin E; D001205:Ascorbic Acid