[The relation of local immune status to efficacy of immunotherapy in patients with condyloma acuminatum].
OBJECTIVE
To study the local immune status and its relation to immunotherapy in patients with condyloma acuminatum.


METHODS
Clinical efficacy of 5% imiquimod cream in treating 30 patients with condyloma acuminatum was observed. The expressions of Human Leukocyte Antigen (HLA)-DR, CD1a, CD16 and Intercellular Adhesion Molecule (ICAM)-1 were detected by immunohistochemistry in lesions of these patients before treatment.


RESULTS
The imiquimod cream was found to be efficacious in 20 cases after 8 weeks' treatment. Before treatment, the expressions of HLA-DR, CD1a, CD16 and ICAM-1 in the lesions of responders were significantly higher than those in the lesions of nonresponders (P<0.05).


CONCLUSIONS
Higher expressions of HLA-DR, CD1a, CD16 and ICAM-1 suggested that immunotherapy might have efficacy in treating condyloma acuminatum.
Zhang
Min
M
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Yi-zhi
YZ
Wang
Lin
L
Wang
Sheng
S
Li
Feng-yuan
FY
D000287:Administration, Topical; D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage*; D003218:Condylomata Acuminata / Q000276:immunology / Q000628:therapy*; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology / Q000628:therapy*; D005832:Genital Diseases, Male / Q000276:immunology / Q000628:therapy*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D000077271:Imiquimod; D007167:Immunotherapy; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000096:biosynthesis
D000634:Aminoquinolines; D006684:HLA-DR Antigens; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG; D018799:Intercellular Adhesion Molecule-1; D000077271:Imiquimod