title: Koniamborine, the first pyrano[3,2-b]indole alkaloid and other secondary metabolites from Boronella koniambiensis.
abstract: Two new alkaloids, (-)-cis-1,2-dihydroxy-1,2-dihydromedicosmine (3) and koniamborine (4), have been isolated from Boronella koniambiensis aerial parts. Their structures have been established from NMR and mass data. Koniamborine is a novel type of alkaloid, which derives from the pyrano[3,2-b]indole basic skeleton, described for the first time from nature. 6-Methoxy-1-methylisatin, also present in the plant material, can be considered biogenetically as a degradation product of the fused pyrone ring of 4.
authors.affiliation: Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Grougnet
authors.forename: Prokopios
authors.initials: P
authors.lastname: Magiatis
authors.forename: Nikolas
authors.initials: N
authors.lastname: Fokialakis
authors.forename: Sofia
authors.initials: S
authors.lastname: Mitaku
authors.forename: Alexios-Leandros
authors.initials: AL
authors.lastname: Skaltsounis
authors.forename: François
authors.initials: F
authors.lastname: Tillequin
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification*; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D009510:New Caledonia; D027821:Rutaceae / Q000737:chemistry*
chemical_list: C503025:1,2-dihydroxy-1,2-dihydromedicosmine; D006576:Heterocyclic Compounds, 4 or More Rings; D026121:Indole Alkaloids; C503024:koniamborine