Glycation products as markers and predictors of the progression of diabetic complications.
The structure of a growing number of glycation and advanced glycation end products has been elucidated. Measuring these products can be used to assess cumulative glycemic and glycoxidative damage in diabetes and other chronic conditions. The predictive power of a given glycation product can be tested in large prospective studies that evaluate the risk of developing diabetic micro- and macrovascular disease over years following the quantitative determination of that marker. This article provides a comprehensive review of the field, comparing the merits of each marker, whether in skin, serum, or other tissue. Several conclusions are drawn, one of which identifies skin glycation products as powerful predictors of the risk of developing diabetic complications.
Monnier
Vincent M
VM
Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. vmm3@cwru.edu
Sell
David R
DR
Genuth
Saul
S
D015415:Biomarkers / Q000032:analysis; D003094:Collagen / Q000032:analysis; D048909:Diabetes Complications / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D018450:Disease Progression; D017127:Glycation End Products, Advanced / Q000032:analysis*; D006801:Humans; D012867:Skin / Q000737:chemistry
D015415:Biomarkers; D017127:Glycation End Products, Advanced; D003094:Collagen