[Oxidative injury and serum cytokines in coal workers with pneumoconiosis].
OBJECTIVE
To inquire into the implication of oxidative injury and two cytokines TGF-beta1 and FGF in the occurrence and development of coal worker's Pneumoconiosis.


METHODS
The methods of nitrate reductase, TBA, and xanthine oxidase were used to detect the levels of serum NO, MDA and SOD respectively in 50 patients suffering from coal worker's Pneumoconiosis and 50 healthy controls, then ELISA was performed to detect the level of TGF-beta1 and FGF in the two groups.


RESULTS
The levels of NO and MDA in serum of patients with coal worker's Pneumoconiosis were higher than those in the controls; the level of SOD was lower in the patients than in the controls; and there were statistically significant differences between the two groups (P<0.05). Statistically significant differences in TGF-beta1 and FGF were also noted between the two group.


CONCLUSIONS
In this study, the patients with coal worker's Pneumoconiosis were found to have abnormity of oxyradical reaction, unblanced oxidation/antioxidation state, and abnormally high expression of cytokine, which might have relations with the occurrence and development of coal worker's Pneumoconiosis.
Yao
Wu
W
Department of Occupational Medicine, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Wang
Zhi-ming
ZM
Wang
Mian-zhen
MZ
Wang
Na
N
D000368:Aged; D003032:Coal Mining; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D016676:Macrophages, Alveolar / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D011009:Pneumoconiosis / Q000097:blood* / Q000473:pathology; D013482:Superoxide Dismutase / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D009569:Nitric Oxide; D005346:Fibroblast Growth Factors; D013482:Superoxide Dismutase