Koshikamide A2, a cytotoxic linear undecapeptide isolated from a marine sponge of Theonella sp.
Koshikamide A2 (2) was isolated as a cytotoxic metabolite from a marine sponge of Theonella sp. Its structure was elucidated to be a linear undecapeptide by spectroscopic and chemical methods, together with enzymatic conversion to known koshikamide A1 (1). The new peptide moderately inhibited the growth of P388 murine leukemia cells.
Araki
Takahiro
T
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657.
Matsunaga
Shigeki
S
Fusetani
Nobuhiro
N
D000595:Amino Acid Sequence; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D047232:Theonella / Q000737:chemistry*
D009842:Oligopeptides; C506242:koshikamide A2