Serial proton spectroscopy in a case of adult-onset subacute sclerosing panencephalitis.
A case of subacute sclerosing panencephalitis in a 27-year-old man was serially evaluated with proton magnetic resonance spectroscopy. Metabolic abnormalities included decreased N-acetylaspartate and elevated choline and myo-inositol in a lesion visible on magnetic resonance imaging and in normal-appearing white matter. Lactate appeared increased within the lesion. Metabolic impairment was persistent after intrathecal interferon-alpha treatment. Spectroscopy pointing to ongoing inflammation, gliosis, and possible membrane turnover was more sensitive than imaging in detecting widespread pathology within the white matter.
Michael
Nikolaus
N
Department of Psychiatry, University of Münster, Albert-Schweitzer-Strasse 11, 48129 Münster, Germany.
Erfurth
Andreas
A
Lüdemann
Peter
P
Schuierer
Gerhard
G
Möller
Harald E
HE
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D004565:Electroconvulsive Therapy / Q000379:methods; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007294:Inositol / Q000378:metabolism; D016898:Interferon-alpha / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D013344:Subacute Sclerosing Panencephalitis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*
D007155:Immunologic Factors; D016898:Interferon-alpha; D011522:Protons; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D002794:Choline