title: Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
abstract: Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87, CEP 05508-900 São Paulo, SP, Brazil.
authors.forename: Tereza Cristina
authors.initials: TC
authors.lastname: da Silva
authors.forename: Ana
authors.initials: A
authors.lastname: Paula da Silva
authors.forename: Gokithi
authors.initials: G
authors.lastname: Akisue
authors.forename: José
authors.initials: J
authors.lastname: Luis Avanzo
authors.forename: Márcia
authors.initials: M
authors.lastname: Kazumi Nagamine
authors.forename: Heidge
authors.initials: H
authors.lastname: Fukumasu
authors.forename: Patrícia
authors.initials: P
authors.lastname: Matsuzaki
authors.forename: Paulo
authors.initials: P
authors.lastname: César Raspantini
authors.forename: Mitsue
authors.initials: M
authors.lastname: Haraguchi
authors.forename: Silvana
authors.initials: S
authors.lastname: Lima Górniak
authors.forename: Maria Lúcia Zaidan
authors.initials: ML
authors.lastname: Dagli
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000517:prevention & control*; D000477:Alkylating Agents / Q000633:toxicity; D027703:Amaranthaceae; D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000517:prevention & control*
chemical_list: D000477:Alkylating Agents; D028321:Plant Preparations; D004052:Diethylnitrosamine