title: Serratia marcescens prosthesis infection successfully treated with meropenem after imipenem failure.
abstract: A 78-year-old woman developed an early knee-prosthesis infection due to multiresistant Serratia marcescens that was successfully treated with high-dose meropenem, after failure of a long-term therapy combining imipenem and multiple surgical interventions. Because of its lower neurotoxicity, meropenem might be preferred to imipenem/cilastatin for the treatment of osteo-articular infections due to multiresistant Gram-negative bacilli in the elderly.
authors.affiliation: Service de Maladies Infectieuses et Tropicales, Hôpital Necker, Université Paris V, 149 rue de Sèvres, 75743 Paris Cedex 15, France. aglefort@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Lefort
authors.forename: S
authors.initials: S
authors.lastname: Righi
authors.forename: F
authors.initials: F
authors.lastname: Jauréguy
authors.forename: T
authors.initials: T
authors.lastname: Bégué
authors.forename: M
authors.initials: M
authors.lastname: Robineau
authors.forename: O
authors.initials: O
authors.lastname: Bouchaud
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000368:Aged; D000583:Amikacin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D007720:Knee Prosthesis / Q000382:microbiology*; D000077731:Meropenem; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016868:Serratia Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D012706:Serratia marcescens / Q000187:drug effects* / Q000302:isolation & purification*; D013845:Thienamycins / Q000627:therapeutic use; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D000583:Amikacin; D000077731:Meropenem