[Meta-analysis on the relationship of chlamydia pneumonia infection and coronary heart disease].
OBJECTIVE
To determine the relationship of chlamydia pneumonia (CP) infection and coronary heart disease (CHD).


METHODS
Studies published before 2004 that had reported on correlations between CHD and CP were collected. Studies were sorted into four sorts according to different testing methods. We determined to use either fixed effect model or random effect model according to the result of heterogeneity test. Meta-analysis was done by RevMan 4.2.


RESULTS
Totally 29 studies were included into the review. The odd ratio (OR) to review all literature enzyme-linked immunosorbent assay (ELISA), dot-immunogdd filtration assay (DIGFA), and micro-immunofluorescence (MIF) was 4.00 (3.07, 5.22), 2.86 (1.89, 4.32), 14.89 (1.46, 151.57), and 4.46 (3.15, 6.32).


CONCLUSIONS
CP infection is associated with CHD, CP infection may be one of the risk factors of CHD.
Wang
Shu-kang
SK
Institute of Epidemiology and Statistics, School of Public Health, Shandong University, Jinan 250012, China. wsk2001@sdu.edu
Wang
Jie-zhen
JZ
D000907:Antibodies, Bacterial / Q000097:blood*; D002690:Chlamydia Infections; D016993:Chlamydophila pneumoniae; D003327:Coronary Disease / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D012307:Risk Factors
D000907:Antibodies, Bacterial