title: The continued value of central histopathological review of testicular tumours.
abstract: OBJECTIVE
  Central histopathological review of testicular tumours prior to definitive treatment can have an important impact on patient management. This study was designed to assess the continued value of central review in the light of increasing subspecialization and increased numbers of consultant histopathologists.
  
  
  RESULTS
  The original and review reports of 291 testicular cancer specimens from 1998 to 2002 were analysed, looking particularly at major diagnosis, vascular invasion and the tumour elements within non-seminomatous germ cell tumours (NSGCT). When a diagnosis was altered any effect on subsequent patient management was assessed. There was a discrepancy in tumour type in 11 cases (4%) compared with 6% in 1992-1997. The commonest change was from seminoma to NSGCT or combined germ cell tumour (5/11). There was also diagnostic difficulty with spermatocytic seminoma (3/11). The clinical management of all 11 cases was influenced as a result of the review diagnosis. Discrepancies in vascular invasion were noted in 13 of the 126 NSGCTs (10%) compared with 20% in 1992-1997. Differences in NSGCT tumour elements, though clinically less important, were frequent in both groups.
  
  
  CONCLUSIONS
  There continues to be a small number of significant and clinically important errors identified following central histopathological review of testicular tumours. This study highlights the value of central review and supports its continued practice in the management of testicular tumours.
authors.affiliation: Department of Cellular Pathology, Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Delaney
authors.forename: C D
authors.initials: CD
authors.lastname: Sayers
authors.forename: M A
authors.initials: MA
authors.lastname: Walker
authors.forename: G M
authors.initials: GM
authors.lastname: Mead
authors.forename: J M
authors.initials: JM
authors.lastname: Theaker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D018237:Germinoma / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis; D010338:Pathology, Clinical / Q000592:standards; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018239:Seminoma / Q000175:diagnosis; D013736:Testicular Neoplasms / Q000175:diagnosis*; D013737:Testis / Q000473:pathology