title: Recent advances in proton pump inhibitors.
abstract: Mechanism of action and shortcomings of the approved proton pump inhibitors are reviewed. Advances in the design of new proton pump K(+) and S site inhibitors are presented. Design criteria incorporated into the structure of investigational proton pump inhibitors to address these drawbacks are discussed.
authors.affiliation: Apotex Research Inc, Medicinal Chemistry Department, 150 Signet Drive, Toronto, Ontario M9L 1T9, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Tam
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Leung-Toung
authors.forename: K
authors.initials: K
authors.lastname: Karimian