title: [Roles of glial cell line-derived neurotropic factor in motoneuron development and motoneuron disease].
abstract: OBJECTIVE
  To review research progress of the relation between glial cell line-derived neurotropic factor (GDNF) and motor neuron development and motor neuron disease.
  
  
  METHODS
  The recent articles on GDNF and motor neurons were extensively reviewed. The molecular structure, the mode of action and the route of administration of GDNF were investigated.
  
  
  RESULTS
  GDNF plays extensive roles in the development and disease of motor neuron. GDNF might regulate the development of the motor neurons of the spinal cord to some extent and also save the injured motor neurons.
  
  
  CONCLUSIONS
  GDNF has a potential clinical value and inestimable future in the treatment of motor neuron diseases.
authors.affiliation: Department of Pediatric Surgery, the Major Laboratory of Health Ministry for Congenital Malformation Research, Second Clinical College (Shengjing Hospital), China Medical University, Shenyang Liaoning, 110004, P. R. China.
authors.forename: Weisong
authors.initials: W
authors.lastname: Cai
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000818:Animals; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D016472:Motor Neuron Disease / Q000188:drug therapy* / Q000503:physiopathology; D009046:Motor Neurons / Q000187:drug effects* / Q000502:physiology; D009410:Nerve Degeneration / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor