title: CXCR3 polymorphisms associated with risk of asthma.
abstract: The chemokine (C-X-C motif) receptor 3 (CXCR3) gene, on chromosome Xq13, is known to have critical roles in inflammatory and immune responses. In an effort to discover polymorphisms have been implicated in asthma, we investigated the genetic polymorphisms in CXCR3 to evaluate it as a potential candidate gene for a host genetic study of asthma. Statistical analysis revealed that one SNP in intron 1, c.12+234G > A, showed significant association with the risk of asthma development (P = 0.007, OR = 0.81). By subgroup analyses stratified by gender and atopic status, the genetic effect of c.12+234G > A on asthma was more apparent among male atopic subjects (P = 0.0009, OR = 0.61). Our findings suggest that polymorphisms in CXCR3 might be one of the genetic factors for the risk of asthma development, especially in male atopic subjects. CXCR3 variation/haplotype information identified in this study will provide valuable information and insight into strategies for the control of asthma and its subgroup, atopy.
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., WooLim Lion's Valley, 371-28, Seoul 153-803, Republic of Korea.
authors.forename: Hyun Sub
authors.initials: HS
authors.lastname: Cheong
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
authors.forename: Lyoung Hyo
authors.initials: LH
authors.lastname: Kim
authors.forename: Byung Lae
authors.initials: BL
authors.lastname: Park
authors.forename: Soo-Taek
authors.initials: ST
authors.lastname: Uh
authors.forename: Yong Hooun
authors.initials: YH
authors.lastname: Kim
authors.forename: Gune-Il
authors.initials: GI
authors.lastname: Lym
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Jong-Keuk
authors.initials: JK
authors.lastname: Lee
authors.forename: Hung Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Ha-Jung
authors.initials: HJ
authors.lastname: Ryu
authors.forename: Bok Ghee
authors.initials: BG
authors.lastname: Han
authors.forename: Jun Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Chan
authors.initials: C
authors.lastname: Park
authors.forename: Kuchan
authors.initials: K
authors.lastname: Kimm
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
authors.forename: Bermseok
authors.initials: B
authors.lastname: Oh
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: C515187:CXCR3 protein, human; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine