[Expression of extracellular matrix metalloproteinase inducer during normal pregnancy].
OBJECTIVE
To study the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) during normal pregnancy.


METHODS
The expression of EMMPRIN was studied with immunohistochemistry in normal pregnancy.


RESULTS
The expression of EMMPRIN was obvious, and appeared mainly on membrane of cytotrophoblast, syncytiotrophoblast, cytotrophoblast column of the villi of gestational weeks 6 to 9, mid-term and term placenta and extravillous cytotrophoblast of deciduas of mid-term and term placenta. The expression reached a peak level at gestational week 6 and gradually decreased from week 7 and stabilized to a low level at mid-term and term placenta when the expression of extravillous cytotrophoblast of deciduas was increased.


CONCLUSIONS
EMMPRIN may be an important factor for implantation during early pregnancy and participate in maintaining gestation during mid-term and term pregnancy.
Wang
Yong-qing
YQ
Department of Obstetrics and Gynecology, the Second Hospital of China Medical University, Shenyang 110003, China.
Li
Jun
J
Shang
Tao
T
Wang
Yan-ling
YL
D051926:Basigin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy / Q000378:metabolism*
C497886:BSG protein, human; D051926:Basigin