Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke.
Heart-fatty acid-binding protein (H-FABP) is a small cytosolic protein involved in intracellular fatty acid transport. This protein, highly concentrated in the heart, is quickly released into plasma after myocardial injury. Results from numerous studies suggest that H-FABP is an excellent marker for the early detection of myocardial damage. H-FABP is also expressed in the brain, although in lower concentrations than in the heart. Recent preliminary studies also investigated the usefulness of H-FABP for the diagnosis of acute and chronic neurological disorders. These potential applications of H-FABP in clinical practice are reviewed in this article, with a strong focus on the early diagnosis of acute myocardial infarction and stroke.
Lescuyer
Pierre
P
Department of Bioinformatics and Structural Biology, Biomedical Proteomics Research Group, Geneva University, Geneva, Switzerland. Pierre.Lescuyer@medecine.unige.ch
Allard
Laure
L
Hochstrasser
Denis F
DF
Sanchez
Jean-Charles
JC
D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis; D001930:Brain Injuries / Q000175:diagnosis; D002352:Carrier Proteins / Q000032:analysis*; D042241:Early Diagnosis; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis*; D019636:Neurodegenerative Diseases / Q000175:diagnosis; D020521:Stroke / Q000175:diagnosis*
D015415:Biomarkers; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins