title: A reaction for sp(3)-sp(3) C-C bond formation via cooperation of Lewis acid-promoted/Rh-catalyzed C-H bond activation.
abstract: A new method for intermolecular sp3-sp3 C-C bond formation between primary aliphatic alcohol and olefin by use of a RhCl(PPh3)3 (cat.)/BF3.OEt2 (2.5 equiv)/BuBr (0.5 equiv)/toluene system was first disclosed, which possessed quite significant utilities for organic synthesis, especially for that of secondary alcohols. The most significant aspect is the discovery that rhodium-catalyzed C-H bond activation of alcohols is feasible under Lewis acid-promoted conditions.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Chun-An
authors.initials: CA
authors.lastname: Fan
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Zhao
authors.forename: Wu-Jiong
authors.initials: WJ
authors.lastname: Xia