Aminoglycoside ototoxicity: permeant drugs cause permanent hair cell loss.
Waguespack
J R
JR
Neuroscience Center and Kresge Hearing Laboratories, Louisiana State University Health Sciences Center, New Orleans 70112, USA.
Ricci
A J
AJ
D000617:Aminoglycosides / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D004096:Dihydrostreptomycin Sulfate / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D034381:Hearing Loss / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects*; D040542:Mechanotransduction, Cellular / Q000187:drug effects*; D008954:Models, Biological; D008956:Models, Chemical
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007473:Ion Channels; D004096:Dihydrostreptomycin Sulfate