title: Successful bone marrow transplantation for life threatening xanthogranuloma disseminatum in neurofibromatosis type-1.
abstract: A 2-yr and 9-month-old female patient with neurofibromatosis type-1 presented with hepatomegaly, anemia, thrombocytopenia, and croupy cough and diagnosed with xanthogranuloma disseminatum (XD). She failed chemotherapy consisting of steroids, 6-mercaptopurine and methotrexate. A partial response to HLH-94 therapy that included etoposide and cyclosporine A was initially observed. However, she continued to have significant organ dysfunction without further improvement at 6 months of therapy. She then received matched unrelated donor bone marrow transplantation (BMT) following carmustine, etoposide, cytarabine and melphelan conditioning with complete resolution of symptoms. BMT is an option in therapy-resistant, life threatening XD cases.
authors.affiliation: Division of Hematology/Oncology, Children's Hospital of Michigan, MI 48201, USA. ssavasan@med.wayne.edu
authors.forename: Süreyya
authors.initials: S
authors.lastname: Savaşan
authors.forename: Laurie
authors.initials: L
authors.lastname: Smith
authors.forename: Carolyn
authors.initials: C
authors.lastname: Scheer
authors.forename: Roger
authors.initials: R
authors.lastname: Dansey
authors.forename: Esteban
authors.initials: E
authors.lastname: Abella
mesh_terms: D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009456:Neurofibromatosis 1 / Q000150:complications*; D019172:Transplantation Conditioning; D014972:Xanthogranuloma, Juvenile / Q000209:etiology / Q000628:therapy*