Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities.
The anti-allergic and anti-oxidative activities of curcumin-related compounds (glycosides, reductants and bis-demethoxy analogs) were investigated to elucidate the underlying active mechanisms and structural features of curcumin in exerting these activities. The anti-allergic activities were assessed by measurement of histamine release from rat basophilic leukemia cells, RBL-2H3. Curcumin and tetrahydrocurcumin (THC) caused a marked decrease in histamine release. Glycosides of curcumin, bis-demethoxycurcumin and THC also inhibited the release of histamine, though less potently than curcumin did. The anti-oxidative activities were assessed by measurement of cell-free or cellular radical scavenging. All compounds but diglycosides or bis-demethoxycurcumin analogs distinctly exerted anti-oxidative effects. The relationship between both of these activities revealed that all compounds with potent radical scavenging activities caused a definite decrease in histamine release, but some compounds with non-potent radical scavenging activities also inhibited the histamine release. These results suggest that the hydroxy groups of curcumin play a significant role in exerting both the anti-oxidative and anti-allergic activities, and that most of the compounds develop the anti-allergic activities through mechanisms related to anti-oxidative activities, but some through mechanisms unrelated to anti-oxidation activity.
Suzuki
Makoto
M
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Nakamura
Tomonori
T
Iyoki
Sachi
S
Fujiwara
Akihiro
A
Watanabe
Yuhya
Y
Mohri
Kunihiko
K
Isobe
Kimiaki
K
Ono
Kageyoshi
K
Yano
Shingo
S
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D045744:Cell Line, Tumor; D003208:Concanavalin A / Q000494:pharmacology; D003474:Curcumin / Q000031:analogs & derivatives / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D051381:Rats
D018926:Anti-Allergic Agents; D000975:Antioxidants; D003208:Concanavalin A; D000001:Calcimycin; D003474:Curcumin