[Executive control functions and neuropsychiatric disorders -- perspectives for research und clinical practice].
Executive control functions are higher cognitive functions for complex goal-oriented behavior in situations where routine mechanisms are not available or inappropriate. In clinical practice executive dysfunction presents with deficits in cognitive function as well as social behavior and drive. Executive control functions rely on intact networks involving prefrontal cortex and subcortical structures, which can be modulated by monoaminergic neurotransmitters. Deficits of executive control have been described in a variety of neuropsychiatric disorders. We present a review of the findings with a focus on movement disorders, schizophrenia and affective disorders. We emphasize similarities between these disorders regarding the pathophysiology of fronto-subcortical networks. Based on these similarities, principles of pharmacological and rehabilitative strategies can be applied to the treatment of executive deficits in a variety of neuropsychiatric disorders without being specific for one disease. Since executive dysfunction is highly relevant to prognosis, controlled trials of these treatments are urgently needed.
Kaiser
S
S
Psychiatrische Universitätsklinik Heidelberg.
Mundt
C
C
Weisbrod
M
M
D001480:Basal Ganglia Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D002540:Cerebral Cortex / Q000502:physiology / Q000503:physiopathology; D003071:Cognition / Q000502:physiology*; D015928:Cognitive Behavioral Therapy; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D019964:Mood Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D009069:Movement Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D009422:Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D010554:Personality Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D011597:Psychomotor Performance; D012565:Schizophrenic Psychology