title: Effects of atrial arrhytmias on the regurgitation of a monoleaflet prosthetic heart valve.
abstract: Many patients who receive a prosthetic heart valve also have or acquire cardiac arrhythmias. However, most in vitro studies of prosthetic valves examine them under normal rhythms. In this study, a monoleaflet prosthetic heart valve was tested in vitro under conditions that simulated normal sinus rhythm, first degree atrioventricular heart block, and atrial fibrillation (fixed and variable ventricular rates). Atrial contraction was simulated by an active atrial chamber. The timing between the atrium and ventricle was adjusted to simulate various types of arrhythmias. The closing, leakage, and total regurgitant volumes and fractions increased for each type of atrial arrhythmia when compared to normal sinus rhythm. The peak regurgitant flow increased for first degree atrioventricular heart block and atrial fibrillation with a fixed ventricular rate compared to normal sinus rhythm.
authors.affiliation: Department of Surgery, Division of Artificial Organs, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA. czapanta@psu.edu
authors.forename: Conrad M
authors.initials: CM
authors.lastname: Zapanta
mesh_terms: D001145:Arrhythmias, Cardiac / Q000150:complications*; D001281:Atrial Fibrillation / Q000150:complications; D001705:Bioprosthesis; D006325:Heart Atria; D006327:Heart Block / Q000150:complications; D006349:Heart Valve Diseases / Q000150:complications*; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D066298:In Vitro Techniques; D008955:Models, Cardiovascular