title: Half-life analysis of pancreas and kidney transplants.
abstract: Although graft and patient survival data are available for pancreas and kidney transplants, they are rarely reported in terms of half-life. Our aim was to determine whether a more relevant measure of outcome is patient and allograft half-life. Using the data from the Organ Procurement and Transplantation Network Registry on kidney and pancreas transplants from January 1988 to December 1996, patient and graft half-life and 95% confidence intervals were calculated and demographic variables compared. No significant differences were found between demographic variables. Kidneys transplanted in diabetics as a simultaneous kidney-pancreas (SPK) fared better than diabetics receiving a kidney alone (9.6 vs. 6.3 years). Pancreatic graft survival in an SPK pair was better than pancreas after kidney transplant or pancreas transplant alone (11.2 vs. 2.5 years). Because kidney and pancreatic grafts have a longer half-life when transplanted with their mate grafts, we should consider the relative benefits of SPKs over pancreas after kidney transplant or pancreas transplant alone to limit the loss of precious resources.
authors.affiliation: Duke University Medical Center, Department of Surgery, Durham, NC 27710, USA. marro007@mc.duke.edu
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Marroquin
authors.forename: Erick B
authors.initials: EB
authors.lastname: Edwards
authors.forename: Bradley H
authors.initials: BH
authors.lastname: Collins
authors.forename: Dev M
authors.initials: DM
authors.lastname: Desai
authors.forename: Janet E
authors.initials: JE
authors.lastname: Tuttle-Newhall
authors.forename: Paul C
authors.initials: PC
authors.lastname: Kuo
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000601:surgery; D005006:Ethnicity; D005260:Female; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D016035:Pancreas Transplantation / Q000401:mortality / Q000502:physiology*; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data; D014481:United States / Q000453:epidemiology