Phenserine Axonyx.
The acetylcholinesterase inhibitor phenserine, the (-)-enantiomer of a phenylcarbamate derivative of physostigmine, is being developed as a potential therapy for Alzheimer's disease by Axonyx, under license from the National Institutes of Health/National Institute on Aging. In March 2005, Axonyx suspended patient recruitment for the ongoing phase III trials of phenserine, after the drug failed to meet the primary endpoints of the first of these trials, but in May 2005, the company was planning to reformulate the drug.
Thatte
Urmila
U
Department of Clinical Pharmacology, TN Medical College, Mumbai 400 008, India. mthatte@bom5.vsnl.net.in
D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D015394:Molecular Structure; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D002800:Cholinesterase Inhibitors; D010830:Physostigmine; C092280:phenserine