title: Plasma levels of soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin are associated with relapsing-remitting disease course of multiple sclerosis.
abstract: Adhesion molecule mediated leukocyte migration into the central nervous system is considered to be a critical step in the pathogenesis of multiple sclerosis (MS). We measured plasma levels of the soluble adhesion molecules sPECAM-1, sP-selectin and sE-selectin in 166 MS patients and in 36 healthy blood donors with ELISA. sPECAM-1, sP-selectin and sE-selectin plasma concentrations showed a significant increase in the relapsing-remitting disease course of MS and were elevated during relapse. These findings indicate that sPECAM-1, sP-selectin and sE-selectin might be implemented as paraclinical markers of disease activity in MS with restriction to the clinical course of the disease.
authors.affiliation: Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
authors.forename: Bettina
authors.initials: B
authors.lastname: Kuenz
authors.forename: Andreas
authors.initials: A
authors.lastname: Lutterotti
authors.forename: Michael
authors.initials: M
authors.lastname: Khalil
authors.forename: Rainer
authors.initials: R
authors.lastname: Ehling
authors.forename: Claudia
authors.initials: C
authors.lastname: Gneiss
authors.forename: Florian
authors.initials: F
authors.lastname: Deisenhammer
authors.forename: Markus
authors.initials: M
authors.lastname: Reindl
authors.forename: Thomas
authors.initials: T
authors.lastname: Berger
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000097:blood*; D018450:Disease Progression; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000145:classification / Q000473:pathology; D019007:P-Selectin / Q000097:blood*
chemical_list: D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019007:P-Selectin