title: Postradiation malignant fibrous histiocytoma and osteosarcoma of a patient with high telomerase activities.
abstract: BACKGROUND
  An extremely rare case of postradiation malignant fibrous histiocytoma (MFH) and osteosarcoma (OS) secondary to radiation therapy for leukemia-related osteolytic lesions is presented. In addition, the telomere biology of these tumors was investigated.
  
  
  METHODS
  A 14-year-old boy was diagnosed with acute lymphocytic leukemia. The right tibia was irradiated at a total dose of 60 Gy, and the left tibia was irradiated at a total dose of 40 Gy. The left tibia developed MFH and the right tibia developed OS.
  
  
  RESULTS
  Telomere reduction (MFH 70.2, OS 70.0%) and high telomerase activities (MFH 12.1, OS 17.7 TPG) were observed. These results reflect an aggressive feature of postradiation sarcomas.
  
  
  CONCLUSIONS
  Prognosis for patients diagnosed with postradiation sarcoma is poor due to its aggressiveness. However, even if sarcoma occurs after irradiation in more than two fields in a single patient, improvements in prognosis are anticipated with appropriate chemotherapies and wide resection.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. tmatsuo@hiroshima-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsuo
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
authors.forename: Shoji
authors.initials: S
authors.lastname: Shimose
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Kubo
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yasunaga
authors.forename: Eiso
authors.initials: E
authors.lastname: Hiyama
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000201:enzymology* / Q000209:etiology; D018219:Histiocytoma, Benign Fibrous / Q000201:enzymology* / Q000209:etiology; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000201:enzymology* / Q000209:etiology; D010014:Osteolysis / Q000532:radiotherapy; D012516:Osteosarcoma / Q000201:enzymology* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000532:radiotherapy; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism; D013977:Tibia / Q000528:radiation effects
chemical_list: D019098:Telomerase