title: OK432 (picibanil) efficacy in an adult with cystic cervical lymphangioma. A case report.
abstract: Cervical cystic lymphangioma (CCL) is a rare and benign tumour involving congenital and cystic abnormalities derived from lymphatic vessels. The most accepted treatment continues to be surgical excision. However, when this infiltrates vital neurovascular neck structures, complete excision is difficult and if only partial, the recurrence rate is very high. The most frequently used alternative treatment is to inject sclerosants into the lesion. The use of these techniques has reported good results in children; however, there are few references thereof with regard to adults. We are reporting on a cervical cystic lymphangioma in a male aged 22, treated with an intra-lesion injection of 20 cc with 0.01 mg/cc dilution of OK-432 (picibanil) in physiological serum. Sole complications were fever and local reaction where the solution was injected. One month after treatment the lymphangioma had totally remitted and sixteen months later continues in remittance.
authors.affiliation: Servicio de Cirugía Maxilofacial, Hospital de Cruces, Osakidetza.
authors.forename: Juan
authors.initials: J
authors.lastname: Alonso
authors.forename: Luis
authors.initials: L
authors.lastname: Barbier
authors.forename: Julio
authors.initials: J
authors.lastname: Alvarez
authors.forename: Laura
authors.initials: L
authors.lastname: Romo
authors.forename: Jesús C
authors.initials: JC
authors.lastname: Martín
authors.forename: Iciar
authors.initials: I
authors.lastname: Arteagoitia
authors.forename: Joseba
authors.initials: J
authors.lastname: Santamaría
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D018191:Lymphangioma, Cystic / Q000188:drug therapy*; D008297:Male; D010844:Picibanil / Q000627:therapeutic use*; D012074:Remission Induction; D012597:Sclerosing Solutions / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D012597:Sclerosing Solutions; D010844:Picibanil