Sodium sieving in children.
Sodium sieving is a consequence of dissociation between the amount of water and sodium transported over the peritoneal membrane. This dissociation occurs in the presence of aquaporin-mediated water transport. Sieving of sodium can be used as a rough measure for aquaporin-mediated water transport. Icodextrin contains glucose polymers, inducing ultrafiltration by colloid osmosis. Therefore, aquaporins play a minor role in ultrafiltration, which is confirmed by the absence of sodium sieving. Icodextrin is very suitable for the daytime dwell in children on a nightly intermittent peritoneal dialysis regimen. Ultrafiltration obtained with icodextrin is similar to ultrafiltration obtained with 3.86% glucose after a 12-hour dwell. When using icodextrin in children, it is also confirmed by the absence of sodium sieving that the aquaporins play a minor role in ultrafiltration.
Rusthoven
Esther
E
Department of Pediatric Nephrology and Dialysis, University Medical Center, Utrecht, The Netherlands. erusthoven@xs4all.nl
Krediet
Raymond T
RT
Willems
Hans L
HL
Monnens
Leo A
LA
Schröder
Cornelis H
CH
D020346:Aquaporins / Q000187:drug effects / Q000502:physiology; D001692:Biological Transport; D002648:Child; D002675:Child, Preschool; D015314:Dialysis Solutions / Q000494:pharmacology; D005936:Glucans / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D000077607:Icodextrin; D007223:Infant; D007676:Kidney Failure, Chronic / Q000628:therapy; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010537:Peritoneum / Q000187:drug effects / Q000503:physiopathology*; D012964:Sodium / Q000502:physiology*; D014883:Water-Electrolyte Imbalance / Q000503:physiopathology*
D020346:Aquaporins; D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D012964:Sodium; D005947:Glucose