The emergence of toxicogenomics: a case study of molecularization.
This paper described the efforts of scientists at the National Institute of Environmental Health Sciences (NIEHS) and their allies in the National Toxicology Program to molecularize toxicology by fostering the emergence of a new discipline: toxicogenomics. I demonstrate that the molecularization of toxicology at the NIEHS began in a process of 'co-construction'. However, the subsequent emergence of the discipline of toxicogenomics has required the deliberate development of communication across the myriad disciplines necessary to produce toxicogenomic knowledge; articulation of emergent forms, standards, and practices with extant ones; management of the tensions generated by grounding toxicogenomics in traditional toxicological standards and work practices even it transforms those standards and practices; and identification and stabilization of roles for toxicogenomic knowledge in markets and service sites, such as environmental health risk assessment and regulation. This paper describes the technological, institutional, and inter-sectoral strategies that scientists have pursued in order to meet these challenges. In so doing, this analysis offers a vista into both the means and meanings of molecularization.
Shostak
Sara
S
D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D009316:National Institutes of Health (U.S.); D020411:Oligonucleotide Array Sequence Analysis / Q000266:history*; D043922:Toxicogenetics / Q000266:history*; D014116:Toxicology / Q000266:history; D014481:United States