Acitretin-induced enthesitis in a patient with psoriatic arthritis.
A patient with psoriatic arthritis and cutaneous psoriasis took acitretin for 10 years to treat his skin lesions. Radiographs disclosed exuberant ossifications in several entheses. Their features were not typical for psoriatic arthritis but were consistent with acitretin-induced hyperostosis. Retinoids are known to induce hyperostosis, most notably when they are used in high dosages and over long periods. The concomitant presence of two conditions affecting the entheses may explain the exuberant nature of the ossifications in our patient.
Vincent
Véronique
V
Rheumatology Department, CHU Purpan Teaching Hospital, place du Docteur Baylac, 31059 Toulouse, France. fournie.b@chu-toulouse.fr
Zabraniecki
Laurent
L
Loustau
Olivier
O
Godfrin
Bertrand
B
Latour
Frédérique Bertrand
FB
Railhac
Jean-Jacques
JJ
Fournié
Bernard
B
D017255:Acitretin / Q000009:adverse effects* / Q000627:therapeutic use; D000843:Ankle Joint / Q000000981:diagnostic imaging; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001175:Arthrography; D005500:Follow-Up Studies; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008023:Ligaments, Articular / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D007641:Keratolytic Agents; D017255:Acitretin