[Structural changes in the medullary nucleus ambiguus and cardiac autonomic ganglia of growing rats under influence of the immobilization stress].
The objective of this study was to evaluate the quantitative and qualitative histological changes in the medullary nucleus ambiguus (NA) and cardiac autonomic ganglia (CAG) of the growing organism under the influence of immobilization stress of different duration. The experiments were performed on 56 outbred albino rats with the initial age of 30 days. Immobilization stress was induced by placing the rats into special chambers with a controllable volume of the inner space for 3, 7, 15 and 30 days. NA and CAG were studied on paraffin sections using the neurohistological methods and a quantitative analysis. Morphological and morphometric changes have demonstrated the retardation of the growth of neurocyte cell bodies and of their nuclei both in medullary NA and CAG as compared to those in control animals, which are regarded as an indication of a disturbance of the histogenesis of the nervous tissue in postnatal development. The degree of structural changes of the components of autonomic nervous system studied was directly related to the duration of experimental exposure to immobilization stress.
Smirnov
A V
AV
Pisarev
V B
VB
Samusev
R P
RP
D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D005725:Ganglia, Autonomic / Q000254:growth & development / Q000473:pathology*; D006321:Heart / Q000254:growth & development / Q000294:innervation*; D007103:Immobilization; D008526:Medulla Oblongata / Q000254:growth & development / Q000473:pathology*; D051381:Rats; D013315:Stress, Psychological / Q000209:etiology / Q000473:pathology*