[Finding cholinesterase in endotheliocytes: cholinesterase inhibition by organophosphorus compounds leads to endotheliocyte deformation].
Toxic action of some organophosphorus cholinesterase inhibitors (including phosphacol) on the state of microvessels was studied in rats. Cholinesterase was found in endotheliocytes and it was established that phosphacol inhibited this enzyme. This was one of the factors responsible for deformation of the luminal relief of the vessels and for violation of the blood microcirculation. The expression of these effects was different for various organophosphorus compounds.
Prozorovskiĭ
V B
VB
Skopichev
V G
VG
D000818:Animals; D002196:Capillaries / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002802:Cholinesterases / Q000032:analysis*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology* / Q000648:ultrastructure; D008833:Microcirculation / Q000187:drug effects*; D008855:Microscopy, Electron, Scanning; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010261:Paraoxon / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D002802:Cholinesterases; D010261:Paraoxon