title: Psychophysiological effects of a web-based stress management system: a prospective, randomized controlled intervention study of IT and media workers [ISRCTN54254861].
abstract: BACKGROUND
  The aim of the present study was to assess possible effects on mental and physical well-being and stress-related biological markers of a web-based health promotion tool.
  
  
  METHODS
  A randomized, prospectively controlled study was conducted with before and after measurements, involving 303 employees (187 men and 116 women, age 23-64) from four information technology and two media companies. Half of the participants were offered web-based health promotion and stress management training (intervention) lasting for six months. All other participants constituted the reference group. Different biological markers were measured to detect possible physiological changes.
  
  
  RESULTS
  After six months the intervention group had improved statistically significantly compared to the reference group on ratings of ability to manage stress, sleep quality, mental energy, concentration ability and social support. The anabolic hormone dehydroepiandosterone sulphate (DHEA-S) decreased significantly in the reference group as compared to unchanged levels in the intervention group. Neuropeptide Y (NPY) increased significantly in the intervention group compared to the reference group. Chromogranin A (CgA) decreased significantly in the intervention group as compared to the reference group. Tumour necrosis factor alpha (TNFalpha) decreased significantly in the reference group compared to the intervention group. Logistic regression analysis revealed that group (intervention vs. reference) remained a significant factor in five out of nine predictive models.
  
  
  CONCLUSIONS
  The results indicate that an automatic web-based system might have short-term beneficial physiological and psychological effects and thus might be an opportunity in counteracting some clinically relevant and common stress and health issues of today.
authors.affiliation: Uppsala University, Department of Public Health and Caring Sciences, Section for Social Medicine/CEOS, Uppsala Science Park, SE-751 85 Uppsala, Sweden. dan.hasson@pubcare.uu.se
authors.forename: Dan
authors.initials: D
authors.lastname: Hasson
authors.forename: Ulla Maria
authors.initials: UM
authors.lastname: Anderberg
authors.forename: Töres
authors.initials: T
authors.lastname: Theorell
authors.forename: Bengt B
authors.initials: BB
authors.lastname: Arnetz
mesh_terms: D000328:Adult; D001291:Attitude of Health Personnel; D015415:Biomarkers / Q000097:blood; D053379:Chromogranin A; D002864:Chromogranins / Q000097:blood; D015928:Cognitive Behavioral Therapy; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005246:Feedback; D005260:Female; D006126:Group Processes; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D019451:Information Management; D020407:Internet; D008297:Male; D008402:Mass Media; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood; D009786:Occupational Health Services; D015397:Program Evaluation; D011446:Prospective Studies; D012647:Self-Assessment; D013315:Stress, Psychological / Q000503:physiopathology / Q000628:therapy*; D013548:Sweden; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015415:Biomarkers; D053379:Chromogranin A; D002864:Chromogranins; D009478:Neuropeptide Y; D014409:Tumor Necrosis Factor-alpha; D019314:Dehydroepiandrosterone Sulfate