[Using aphobazol for treatment of the emotional stress after exposure to ionizing radiation].
Emotional stress after radiation may aggravate the course of radiation-induced diseases. The use of the selective anxiolytic aphobazol (a drug from a mercaptobenzamidasol group) corrects development of adaptive reactions to stress in the blood system and normalizes its compensatory potentialities in animals under conditions of combined influence of intensive long-term emotional stress and low-dose irradiation. In lethally irradiated animals the treatment of stressed animals with aphobazol favourably influenced the course of acute radiation disease, enhanced recovery processes in the blood system, increased the animals' survival. The use of aphobazol completely removed a negative effect of emotional stress in indralin-protected animals. Thus, pharmacological correction of the emotional stress caused by different doses of radiation is not only a symptomatic but also a pathogenetically justified form of treatment.
Moroz
B B
BB
Deshevoĭ
Iu B
IuB
Seredenin
S B
SB
Lebedev
V G
VG
Lyrshchikova
A V
AV
D000222:Adaptation, Physiological / Q000528:radiation effects; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D010636:Phenols / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin