title: Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?
abstract: Plasma concentrations of soluble tumor necrosis factor alpha (TNF-alpha) receptor type I (sTNF-RI) were assessed in two complex regional pain syndrome (CRPS) patient groups (n = 30 and n = 16) and healthy controls (n = 25). Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI (1,661.8 +/- 146.8 pg/mL) compared with those with CRPS with identical clinical appearance but without hyperalgesia (1,155.9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS.
authors.affiliation: Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. maihoefner@physiologie1.uni-erlangen.de
authors.forename: Christian
authors.initials: C
authors.lastname: Maihöfner
authors.forename: Hermann O
authors.initials: HO
authors.lastname: Handwerker
authors.forename: Bernhard
authors.initials: B
authors.lastname: Neundörfer
authors.forename: Frank
authors.initials: F
authors.lastname: Birklein
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D020918:Complex Regional Pain Syndromes / Q000097:blood* / Q000503:physiopathology; D004487:Edema / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005727:Ganglia, Spinal / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006930:Hyperalgesia / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000378:metabolism; D036421:Nerve Fibers, Unmyelinated / Q000378:metabolism; D009437:Neuralgia / Q000097:blood / Q000503:physiopathology; D020078:Neurogenic Inflammation / Q000097:blood / Q000503:physiopathology; D009619:Nociceptors / Q000378:metabolism / Q000503:physiopathology; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012737:Sex Factors; D012881:Skin Temperature / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha