title: Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners.
abstract: A series of C-4-anilino- and C-4-imido-substituted new podophyllotoxin congeners have been designed, synthesized, and evaluated for their cytotoxicity and DNA topoisomerase-II (topo-II) inhibition potential. Some of these compounds have exhibited promising in vitro anticancer and topo-II inhibition activity.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, Andhra Pradesh, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: N Lakshmi
authors.initials: NL
authors.lastname: Gayatri
authors.forename: D Rajasekhar
authors.initials: DR
authors.lastname: Reddy
authors.forename: P S Murali
authors.initials: PS
authors.lastname: Mohan Reddy
authors.forename: M
authors.initials: M
authors.lastname: Arifuddin
authors.forename: Sunanda G
authors.initials: SG
authors.lastname: Dastidar
authors.forename: Anand K
authors.initials: AK
authors.lastname: Kondapi
authors.forename: M
authors.initials: M
authors.lastname: Rajkumar
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007094:Imides / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors
chemical_list: D000814:Aniline Compounds; D000970:Antineoplastic Agents; D007094:Imides; D011355:Prodrugs; D059005:Topoisomerase II Inhibitors; D011034:Podophyllotoxin; C023650:aniline