title: Nonsteroidal anti-inflammatory drugs for rheumatoid arthritis during pregnancy.
abstract: OBJECTIVE
  I am treating two pregnant patients who have rheumatoid arthritis with nonsteroidal anti-inflammatory drugs. Are these medications safe at high doses during pregnancy?
  
  
  CONCLUSIONS
  While these medications do not appear to increase overall rates of congenital malformations, they do increase the risk of ductus arteriosus constriction or closure.
authors.affiliation: Motherisk Program, Hospital for Sick Children, Toronto, Ont.
authors.forename: Ana
authors.initials: A
authors.lastname: Florescu
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004374:Ductus Arteriosus, Patent / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012306:Risk
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal