Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps.
da Silva
Tereza Cristina
TC
Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87, CEP 05508-900 São Paulo, SP, Brazil.
Paula da Silva
Ana
A
Akisue
Gokithi
G
Luis Avanzo
José
J
Kazumi Nagamine
Márcia
M
Fukumasu
Heidge
H
Matsuzaki
Patrícia
P
César Raspantini
Paulo
P
Haraguchi
Mitsue
M
Lima Górniak
Silvana
S
Dagli
Maria Lúcia Zaidan
ML
D000236:Adenoma / Q000139:chemically induced / Q000517:prevention & control*; D000477:Alkylating Agents / Q000633:toxicity; D027703:Amaranthaceae; D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000517:prevention & control*
D000477:Alkylating Agents; D028321:Plant Preparations; D004052:Diethylnitrosamine