title: Bilateral progressive enophthalmos as the presenting sign of metastatic breast carcinoma.
abstract: A 51-year-old woman, without systemic symptoms, complained of slowly progressive receding eyes. She had severe bilateral enophthalmos and markedly restricted extraocular movements in all fields of gaze. Computed tomography showed an infiltrative homogenous mass filling both orbits. Gynecologic and systemic investigation revealed bilateral lobular breast carcinoma, without metastasis to other organs. She was started on chemotherapy and 2 years after the diagnosis remains in good general health, despite persistence of severe enophthalmos. This case serves to emphasize that bilateral progressive enophthalmos may be the presenting sign of metastatic breast carcinoma even when local symptoms in the breast are absent. Clinicians should be aware of this sign to establish an early diagnosis and treatment.
authors.affiliation: Department of Ophthalmology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Allan C P
authors.initials: AC
authors.lastname: Gonçalves
authors.forename: Frederico C
authors.initials: FC
authors.lastname: Moura
authors.forename: Mário L R
authors.initials: ML
authors.lastname: Monteiro
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D015841:Enophthalmos / Q000175:diagnosis*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide