[Influence of Xinqin tablets on guinea-pig nasal hypersensitivity].
OBJECTIVE
To study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity.


METHODS
2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase (NOS) were examined.


RESULTS
Xinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase.


CONCLUSIONS
Xinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.
Zhang
Rong
R
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Yu
Yan
Y
Du
Jun-rong
JR
Liu
Jian
J
Zhang
Jie
J
Wei
Ting
T
Li
Xin
X
Li
Jiang
J
Long
Rui
R
D000818:Animals; D030023:Asarum / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D031363:Scutellaria / Q000737:chemistry; D014051:Toluene 2,4-Diisocyanate
D004365:Drugs, Chinese Herbal; C000617119:xinqin; D014051:Toluene 2,4-Diisocyanate; D006632:Histamine; D019001:Nitric Oxide Synthase