title: Prevalence of moderate or severe left ventricular diastolic dysfunction in obese persons with obstructive sleep apnea.
abstract: We investigated prior to gastric bypass surgery the prevalence of left ventricular diastolic dysfunction (LVDD) by Doppler and tissue Doppler echocardiography in 14 obese women and in 6 obese men, mean age 45 years, with a mean body mass index of 49+/-5 kg/m2 who had nocturnal polysomnography for obstructive sleep apnea (OSA). The Doppler and tissue Doppler echocardiographic data were analyzed blindly without knowledge of the clinical characteristics or whether OSA was present or absent. Of 20 patients, 8 (40%) had no OSA, 4 (20%) had mild OSA, and 8 (40%) had moderate or severe OSA. Moderate or severe LVDD was present in 4 of 8 patients (50%) with moderate or severe OSA and in none of 12 patients (0%) with no or mild OSA (p<0.01). Obese patients with moderate or severe OSA have a higher prevalence of moderate or severe LVDD than obese patients with no or mild OSA.
authors.affiliation: Department of Medicine, Divisions of Cardiology and Pulmonary/Critical Care, New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Jasdeep
authors.initials: J
authors.lastname: Sidana
authors.forename: Wilbert S
authors.initials: WS
authors.lastname: Aronow
authors.forename: Gautham
authors.initials: G
authors.lastname: Ravipati
authors.forename: Brian
authors.initials: B
authors.lastname: Di Stante
authors.forename: John A
authors.initials: JA
authors.lastname: McClung
authors.forename: Robert N
authors.initials: RN
authors.lastname: Belkin
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Lehrman
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D015992:Body Mass Index; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D017286:Polysomnography; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000453:epidemiology*