title: Higher lesion conspicuity for SENSE dynamic MRI in detecting hypervascular hepatocellular carcinoma: analysis through the measurements of liver SNR and lesion-liver CNR comparison with conventional dynamic MRI.
abstract: The aim of our study was to compare the signal-to-noise ratio (SNR) of liver parenchyma and the contrast-to-noise ratio (CNR) of hypervascular hepatocellular carcinoma (HCC) between conventional and SENSE dynamic MRI. Thirty-one consecutive patients who were strongly suspected of having HCC were enrolled in our study. The subjects consisted of 20 men and 11 women aged 52 years to 79 years (mean 66.8 years). Dynamic MRI was performed for each patient, with SENSE (SENSE MRI) and without SENSE (conventional MRI) on separate days. For the quantitative analysis, the liver SNR and the lesion-liver CNR of 25 hypervascular HCCs detected on both conventional and SENSE dynamic MRI were measured. The liver SNR of the arterial phase and the portal venous phase was 84.1+/-24.7 and 104.7+/-34.3, respectively, in conventional MRI, while it was 62.9+/-19.5 and 44.5+/-18.2, respectively, in SENSE MRI. SENSE MRI showed a statistically significantly lower SNR than conventional MRI (P<0.01). The lesion-liver CNR was 26.3+/-15.9 in conventional MRI and 39.0+/-19.6 in SENSE MRI. The lesion-liver CNR in SENSE MRI was significantly higher than in conventional MRI (P<0.01). The SNR in SENSE MRI is significantly lower than in conventional MRI, although the lesion CNR is significantly higher than in conventional MRI.
authors.affiliation: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan. otanaka@koto.kpu-m.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Tanaka
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Ito
authors.forename: Kei
authors.initials: K
authors.lastname: Yamada
authors.forename: Takao
authors.initials: T
authors.lastname: Kubota
authors.forename: Osamu
authors.initials: O
authors.lastname: Kizu
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kato
authors.forename: Takuji
authors.initials: T
authors.lastname: Yamagami
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA