title: Type III mixed cryoglobulinemia associated with digital necrotic ulcer successfully treated with intermittent intravenous pulse cyclophosphamide--a case report.
abstract: Cryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin Glambda (IgGlambda) and IgMlambda type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.
authors.affiliation: Department of Cardiovascular, Dicle University of Medicine, Diyarbakir, Turkey. omercak@dicle.edu.tr
authors.forename: Omer
authors.initials: O
authors.lastname: Cakir
authors.forename: Orhan
authors.initials: O
authors.lastname: Ayyildiz
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Isikdogan
mesh_terms: D000293:Adolescent; D003449:Cryoglobulinemia / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D005385:Fingers / Q000098:blood supply / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous / Q000379:methods*; D009336:Necrosis; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide