Preclinical evidence for GABAB agonists as a pharmacotherapy for cocaine addiction.
A variety of studies indicate that GABA(B) receptor agonists may be useful in the treatment of addictive disorders. This brief review summarizes self-administration studies in rats which show that baclofen and other GABA(B) agonists may have specific effects on the reinforcing effects of cocaine. Preliminary clinical data with baclofen have also been encouraging. The obstacles and issues related to the use of GABA drugs in addiction therapy are briefly addressed.
Roberts
David C S
DC
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. dcsrobts@wfubmc.edu
D000818:Animals; D019970:Cocaine-Related Disorders / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D051381:Rats
D018755:GABA Agonists