Recent advances in renal phosphate transport.
Phosphate (Pi) homeostasis is achieved by adjusting the intestinal absorption and the renal excretion. Renal proximal reabsorption of Pi is regulated by controlling the amount of NaPi-IIa cotransporters in the brush border membrane of proximal tubules. Therefore, the understanding of the molecular mechanisms that control the apical expression of NaPi-IIa is required to have a full picture of how phosphate balancing takes place. In this review we will summarize our present knowledge about the mechanisms involved in the regulation of the apical expression and membrane retrieval of this family of transporters.
Hernando
Nati
N
Physiologisches Institut, Universität Zürich-Irchel, Zurich, Switzerland. hernando@physiol.unizh.ch
Biber
Jürg
J
Forster
Ian
I
Murer
Heini
H
D000042:Absorption; D000818:Animals; D001692:Biological Transport; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D015398:Signal Transduction
D010710:Phosphates