title: Biological compatibility of polymethyl methacrylate, hydrophilic acrylic and hydrophobic acrylic intraocular lenses.
abstract: OBJECTIVE
  Extensive clinical investigations of the biocompatibility of different intraocular lenses (IOLs) have been made in an effort to optimize the outcome of modern cataract surgery. The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs.
  
  
  METHODS
  Thirteen adult albino rabbits had phacoemulsification/aspiration of the crystalline lens followed by implantation of a posterior chamber IOL in each eye. Three types of IOLs were studied: Hydroview (Bausch and Lomb; n = 7), Acrysof (Alcon, USA; n = 7), and polymethyl methacrylate (PMMA; HOYA, Japan; n = 7). The animals were killed by intravenous pentobarbital 1, 4, or 8 weeks later. The IOLs were explanted and stained with hematoxylin and eosin, and observed under a light microscope. The shape of mouse ascites-induced macrophages on the anterior surface of the three different IOL types (Hydroview, PMMA, and Acrysof) was studied after 24 h of oven culture.
  
  
  RESULTS
  Hydrophilic acrylic IOLs showed the highest affinity for lens epithelial cell (LEC) outgrowth, and the lowest and slowest maturation rate reaction of macrophages. PMMA IOLs showed the lowest affinity for LEC outgrowth, and the highest reaction of macrophages. Hydrophobic acrylic IOLs showed intermediate results both regarding LECs and macrophages.
  
  
  CONCLUSIONS
  Results suggest that IOL biomaterial properties are the key factor that influences the quantity of monocytes/macrophages as well as the process of their maturation/senescence. LEC outgrowth is influenced both by the biomaterial of IOLs and by the monocyte/macrophage reaction.
authors.affiliation: Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan. w.barbour@doctor.com
authors.forename: Walid
authors.initials: W
authors.lastname: Barbour
authors.forename: Shizuya
authors.initials: S
authors.lastname: Saika
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ohnishi
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D004847:Epithelial Cells / Q000166:cytology; D015726:Giant Cells / Q000166:cytology; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000166:cytology; D007910:Lenses, Intraocular; D008264:Macrophages / Q000166:cytology; D009000:Monocytes / Q000166:cytology; D018918:Phacoemulsification; D019904:Polymethyl Methacrylate; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D019904:Polymethyl Methacrylate