The ganglioside GD3 as the Greek goddess Hecate: several faces turned towards as many directions.
The disialoganglioside GD3 can mediate biological functions as diverse as proliferation, differentiation, and apoptosis. Since intracellular level of GD3 is crucial for the cell, understanding the mechanisms by which GD3 metabolism is tightly regulated seems of particular importance. GD3 can be enlisted among the most potent natural inducers of mitochondrial damage and apoptosis. However, some cell types resist GD3-mediated mitochondrial damage through complex mechanisms which are beginning to be unveiled.
Malisan
Florence
F
Laboratory of Immunology and Signal Transduction, Department of Experimental Medecine and Biochemical sciences, University "Tor Vergata", Rome, Italy. malisan@med.uniroma2.it
Testi
Roberto
R
D000818:Animals; D005732:Gangliosides / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*
D005732:Gangliosides; C026226:ganglioside, GD3