Morphinane alkaloids with cell protective effects from Sinomenium acutum.
One new morphinane alkaloid, sinomenine N-oxide (1), and one new natural occurring morphinane alkaloid, N-demethylsinomenine (2), together with six known alkaloids, 7,8-didehydro-4-hydroxy-3,7-dimethoxymorphinan-6-ol (3), sinomenine (4), sinoacutine (5), N-norsinoacutine, acutumine, and acutumidine, were isolated from the stems of Sinomenium acutum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 2, 3, and 5 have protective effects against hydrogen peroxide-induced cell injury.
Bao
Guan-Hu
GH
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Qin
Guo-Wei
GW
Wang
Rui
R
Tang
Xi-Can
XC
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000633:toxicity*; D015394:Molecular Structure; D009019:Morphinans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D032841:Sinomenium / Q000737:chemistry*; D014947:Wounds and Injuries / Q000139:chemically induced
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D009019:Morphinans; C503036:sinomenine N-oxide; D006861:Hydrogen Peroxide