[Study on determination of desloratadine in human serum and its pharmacokinetics by HPLC/MS].
To study the determination of desloratadine in human serum and its pharmacokinetics in healthy volunteers.



A single oral dose of 10 mg desloratadine was given to 18 healthy volunteers. The serum concentrations of desloratadine were determined by HPLC-MS assay. The pharmacokinetics parameters of desloratadine tablets were calculated with program 3P97.



The main pharmacokinetics parameters of desloratadine tablets were as followsút(max)(1.611 +/-0.366)h, C(max) (4.455+/-1.990)microg x L(-1), AUC(0-t) (58.50+/-21.34)microg x L(-1) x h(-1), AUC(0-infinity) (60.59+/-22.32)microg x L(-1) x h(-1), t(1/2(ke)) (20.303+/-5.833)h, Ke (0.0372+/-0.0116)h(-1) and CL(0.1838+/-0.0563)L x h(-1).



Desloratadine tablet is absorbed quicker in the 18 healthy volunteers than the reports and its peak blood concentration reached at 1.5 h after oral administration with t(1/2) 20 h.
Lu
Xiao-yang
XY
Department of Clinical Pharmacology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Sheng-Tu
Jian-zhong
JZ
Chen
Zhi-gen
ZG
Huang
Ming-zhu
MZ
Zhou
Hui-li
HL
Zheng
Guo-gang
GG
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D039563:Histamine H1 Antagonists, Non-Sedating / Q000097:blood* / Q000493:pharmacokinetics*; D006801:Humans; D017336:Loratadine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D013058:Mass Spectrometry / Q000379:methods
D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; C121345:desloratadine