Usefulness of serum endothelin levels in predicting death and myocardial infarction but not coronary progression in postmenopausal women with coronary disease (from the Women's Angiographic Vitamin and Estrogen [WAVE] study).
We performed a cohort study of 392 postmenopausal women who had coronary disease to assess whether baseline serum endothelin-1 level predicts angiographic disease progression, nonfatal myocardial infarction, or death. Angiographic progression was defined as the annualized change in minimal lumen diameter of all qualifying lesions for each patient. Twenty-nine patients died or had a myocardial infarction during follow-up. Each picogram per milliliter increase in endothelin-1 was associated with a 1.8-fold increased risk of death or myocardial infarction. After adjustment for potential confounders, endothelin-1 remained a predictor of clinical events but was not correlated with angiographic progression.
Ruo
Bernice
B
Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Tripputi
Mark T
MT
Hsue
Priscilla Y
PY
Saigo
Masahiko
M
Ouyang
Pamela
P
Waters
David D
DD
D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D018450:Disease Progression; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging; D017698:Postmenopause; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic
D015415:Biomarkers; D019332:Endothelin-1