[Progress in research on function and mechanism of cardiac vascular system of taurine].
The function for cardiac vascular system of taurine is extensive, and the mechanism is complicated. Taurine protects the cells from the cell injury caused by ischemia etc. Through repressing apoptosis, prevents endothelial dysfunction caused by hyperglycemia, hypercholesterolemia, smoking and homocysteine; suppresses the proliferation and calcification in vascular smooth muscle cells, promotes metabolization and excretion of cholesterol in the animal models of hyperlipemia, and confers the resistance to an oxidant, hypochlorous acid, produced by neutrophil on cells, and taurine chrolamine to inhibit activation of NF-kappaB, which might be associated with anti-atherosclerotic effect. Taurine mainly acts inside the cell. However, taurine transport system becomes aberrant in pathological myocardial and vascular tissue. In addition, taurine improves cardiovascular function in fructose-induced hypertension and an iron-overload murine animal models.
Hua
Hao-ming
HM
Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
Ito
Takashi
T
Qiu
Zhi-gang
ZG
Azuma
Junichi
J
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008419:Materia Medica / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000473:pathology; D013654:Taurine / Q000494:pharmacology*
D000975:Antioxidants; D008419:Materia Medica; D013654:Taurine