Macular thickness after cataract surgery with intracameral cefuroxime.
OBJECTIVE
To determine whether the use of prophylactic intracameral cefuroxime during phacoemulsification cataract surgery is associated with increased macular thickening in the postoperative period.


METHODS
Hull and East Yorkshire Eye Hospital, Hull, United Kingdom.


METHODS
In this prospective randomized double-masked clinical study, the study group received 1 mg of intracameral cefuroxime and the control group received intracameral balanced salt solution only. Ocular coherence tomography was performed 5 (+/-1) weeks after surgery.


RESULTS
Intracameral cefuroxime did not have a statistically significant effect on postoperative macular thickness compared with nonadministration of intracameral antibacterials. All patients in both groups achieved a postoperative best corrected visual acuity of 6/9 or better.


CONCLUSIONS
Use of 1 mg of intracameral cefuroxime was not associated with increased macular thickness 4 weeks to 6 weeks postoperatively.
Gupta
Mamta S
MS
Hull and East Yorkshire Eye Hospital, Hull, Yorkshire, UK. sgupta6502@aol.com
McKee
Hamish D R
HD
Saldaña
Manuel
M
Stewart
Owen G
OG
D000085:Acetates / Q000008:administration & dosage; D000867:Anterior Chamber / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002444:Cefuroxime / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D019654:Lens Implantation, Intraocular; D008269:Macular Edema / Q000139:chemically induced / Q000175:diagnosis; D008903:Minerals / Q000008:administration & dosage; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012965:Sodium Chloride / Q000008:administration & dosage; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects
D000085:Acetates; D000900:Anti-Bacterial Agents; C030660:BSS solution; D004338:Drug Combinations; D008903:Minerals; D012965:Sodium Chloride; D002444:Cefuroxime