title: Herpes simplex virus type 2 status at age 26 is not related to early circumcision in a birth cohort.
abstract: OBJECTIVE
  The objective of this study was to determine if circumcision in early childhood affects the risk of acquiring herpes simplex virus type 2 (HSV-2) infection.
  
  
  METHODS
  Study members were born in 1972-1973 in Dunedin, New Zealand. Circumcision status was sought at age 3, when the cohort was established. Information about sexual behavior was obtained at ages 21 and 26. Serum was tested for HSV-2 antibodies at age 26 for 435 men (82.9% of the surviving cohort).
  
  
  RESULTS
  Of eligible men, 40.2% had been circumcised. The prevalence of HSV-2 antibodies was 7.3% in uncircumcised men and 7.4% in circumcised men. Social and sexual factors were very similar between the 2 groups and adjustment had no effect on the association (odds ratio, 1.1; 95% confidence interval, 0.46-2.5). Seroconversion rates according to years since first sexual intercourse were 0.85 and 0.86 per 100 person-years for uncircumcised and circumcised men.
  
  
  CONCLUSIONS
  The results support a lack of association between circumcision status and HSV-2 acquisition, although a small effect cannot be ruled out.
authors.affiliation: Department of Preventive and Social Medicine, University of Otago Medical School, Dunedin, New Zealand. nigel.dickson@stonebow.otago.ac.nz
authors.forename: Nigel
authors.initials: N
authors.lastname: Dickson
authors.forename: Thea
authors.initials: T
authors.lastname: van Roode
authors.forename: Charlotte
authors.initials: C
authors.lastname: Paul
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002944:Circumcision, Male / Q000706:statistics & numerical data*; D015331:Cohort Studies; D006558:Herpes Genitalis / Q000097:blood / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D018258:Herpesvirus 2, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D015995:Prevalence
chemical_list: D000914:Antibodies, Viral