title: Stereoselective reduction of ketones by Daucus carota hairy root cultures.
abstract: Reduction of acetophenone by Daucus carota hairy root cultures afforded (S)-phenylethanol in high yield (96%) and excellent enantiomeric excess (ee>or=98%). Aromatic ketones, keto esters, and a simple aliphatic ketone were reduced with good stereoselectivity (ee=62-98%) and moderate to high chemical yields (25-90%).
authors.affiliation: Département de chimie, Faculté des sciences et de génie, CREFSIP, Université Laval, G1K 7P4, Québec , QC, Canada.
authors.forename: Dave
authors.initials: D
authors.lastname: Caron
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Coughlan
authors.forename: Mathieu
authors.initials: M
authors.lastname: Simard
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bernier
authors.forename: Yves
authors.initials: Y
authors.lastname: Piché
authors.forename: Robert
authors.initials: R
authors.lastname: Chênevert
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000378:metabolism; D001711:Biotransformation; D018552:Daucus carota / Q000378:metabolism*; D007659:Ketones / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D010626:Phenylethyl Alcohol / Q000737:chemistry / Q000378:metabolism; D018517:Plant Roots / Q000378:metabolism*; D013237:Stereoisomerism; D046509:Tissue Culture Techniques
chemical_list: D000098:Acetophenones; D007659:Ketones; D010626:Phenylethyl Alcohol; C038699:acetophenone