title: [Sensitivity of nanoparticlized cefazolin sodium to the bacteria in vitro].
abstract: OBJECTIVE
  To investigate whether the in vitro sensitivity of cefazolin sodium to the bacteria was altered after nanoparticlization.
  
  
  METHODS
  The minimal inhibitory concentrations (MIC) of cefazolin sodium before and after nanoparticlization to S. aureaus and E. coli. were determined by microdilution.
  
  
  RESULTS
  The MIC of nanoparticlized cefazolin sodium to S. aureaus and E. coli. had no significant change compared with that of non-nanoparticlized one.
  
  
  CONCLUSIONS
  Nanoparticlization will not decrease the sensitivity of cefazolin sodium to the bacteria.
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zou
authors.forename: Xue-Gong
authors.initials: XG
authors.lastname: Fan
authors.forename: Hui
authors.initials: H
authors.lastname: Gui
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D049329:Nanostructures; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin