title: Phenanthroindolizidine alkaloids from the stems of Ficus septica.
abstract: In addition to six known phenanthroindolizidine alkaloids, eight new alkaloids, namely, ficuseptines B-D (1-3), 10R,13aR-tylophorine N-oxide (4), 10R,13aR-tylocrebrine N-oxide (5), 10S,13aR-tylocrebrine N-oxide (6), 10S,13aR-isotylocrebrine N-oxide (7), and 10S,13aS-isotylocrebrine N-oxide (8), were isolated from a methanol extract of the stems of Ficus septica. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Cytotoxicity of some of these alkaloids was assessed in vitro using the HONE-1 and NUGC cell lines.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China.
authors.forename: Amooru G
authors.initials: AG
authors.lastname: Damu
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Li-Shian
authors.initials: LS
authors.lastname: Shi
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Li
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Kuoh
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Wu
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030681:Ficus / Q000737:chemistry*; D006801:Humans; D007212:Indolizines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007212:Indolizines; D010616:Phenanthrenes; C503000:ficuseptine B; C503001:ficuseptine C; C503002:ficuseptine D