title: Bone mineral content, corrected for height or bone area, measured by DXA is not reduced in children with chronic renal disease or in hypoparathyroidism.
abstract: The combination of poor growth and parathyroid and mineral disorders complicates the diagnosis of renal bone disease in children with chronic renal insufficiency (CRI), and the role of dual X-ray absorptiometry (DXA) is unclear. We aimed to examine the role of DXA in assessing variation in size-adjusted bone mineral content (BMC) in children with CRI and compare it with a cohort with hypoparathyroidism (HPT) and pseudo-hypoparathyroidism (PHPIa). In 29 patients with CRI (21 male) with a median age of 11 years (10th, 90th centiles 4.4, 14.6) and 10 patients with HPT and PHPIa (three male), with a median age of 13.7 years (7, 16) lumbar spine (LS) and total body (TB) BMC were measured by DXA. Age-, gender- and height-matched data allowed calculation of percentage predicted bone area for age and gender (pBAr) and percentage predicted BMC for bone area and height. In the CRI group, the median glomerular filtration rate (GFR) was 27.4 ml/min per 1.73 m2 (7.1, 69.5), and the median duration of illness was 9.3 years (2.1, 12.1). Median height standard deviation score (Ht SDS) was -1.6 (-3.0, 0.3), and, as expected, median LS and TB pBAr were low at 82% (68, 974) and 76% (63, 92), respectively. LS and TB predicted BMC (pBMC) SDS (corrected for bone size) were generally high, with a median value of 0.4 (-0.9, 1.4) and 0.4 (-0.1,0.9), respectively. Analysis of the prepubertal subset of children (n=15) showed that median percentage predicted LS BMC for height was 104% (80, 116), whereas the median TB BMC for height was 96% (74, 108). Median Ht SDS of the HPT and PHPIa cohort was -0.3 (-2.9, 0.3) and median LS and TB pBAr were 90% (66, 100) and 91% (76, 98), respectively. Median LS and TB pBMC SDS were 0.6 (-0.4, 1.8) and 0.7 (0.3, 1.1), respectively. Median percentage predicted LS and TB BMC for height were 102% (82, 114) and 102% (92, 122). There was no relationship between pBMC SDS and duration of illness, GFR, vitamin D dose, serum intact parathyroid hormone (PTH), serum calcium/phosphate product or serum total alkaline phosphatase (ALP) in the CRI or the HPT cohort. However, one of the highest pBMC SDSs was recorded in a child with PHPIa before she started on any treatment. In children with CRI, BMC, when adjusted for co-existing growth retardation, is similar to that observed in children with hypoparathyroidism. The correct reading of BMC needs a correction for bone size.
authors.affiliation: Bone and Endocrine Research Group, Department of Child Health, Royal Hospital For Sick Children, Yorkhill, Glasgow, G3 8SJ, UK. gcl328@clinmed.gla.ac.uk
authors.forename: S Faisal
authors.initials: SF
authors.lastname: Ahmed
authors.forename: Shiuli
authors.initials: S
authors.lastname: Russell
authors.forename: Rajeeb
authors.initials: R
authors.lastname: Rashid
authors.forename: T James
authors.initials: TJ
authors.lastname: Beattie
authors.forename: Anna V
authors.initials: AV
authors.lastname: Murphy
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Ramage
authors.forename: Heather
authors.initials: H
authors.lastname: Maxwell
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001827:Body Height; D015519:Bone Density; D001842:Bone and Bones / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size; D011547:Pseudohypoparathyroidism / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology