Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study.
Motivated by strong correlations between plasma levels of triglycerides (TG) and adiposity traits, we conducted a series of bivariate genome-wide linkage analyses of TG with body mass index (BMI), total fat mass (FAT), percentage of body fat (FATPC), and abdominal subcutaneous fat (ASF). Maximum lod scores of 3.3, 3.0, 2.2 and 2.4, respectively, were found on chromosome 19q13. This linkage region includes the APOE gene, a predictor of variation in lipid-lipoprotein levels, and the hormone-sensitive lipase (LIPE) gene, a key enzyme in the mobilization of fatty acids from triglyceride stores. In addition, the adiposity measures together with the APOE marker showed significant association with TG levels (p = 0.02 to p = 0.03). In summary, these results suggest that one or more QTLs in the 19q13 region jointly influence TG levels and adiposity. Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL.
Feitosa
Mary F
MF
Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S. Euclid, St. Louis, MO 63110-1093, USA. maryf@wubios.wustl.edu
Rice
Treva
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North
Kari E
KE
Kraja
Aldi
A
Rankinen
Tuomo
T
Leon
Arthur S
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Skinner
James S
JS
Blangero
John
J
Bouchard
Claude
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Rao
D C
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D050154:Adiposity / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D044383:Black People / Q000235:genetics; D015992:Body Mass Index; D002888:Chromosomes, Human, Pair 19; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D009765:Obesity / Q000097:blood / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D002787:Sterol Esterase / Q000235:genetics; D014280:Triglycerides / Q000097:blood / Q000235:genetics*; D044465:White People / Q000235:genetics
D001057:Apolipoproteins E; D014280:Triglycerides; D002787:Sterol Esterase