title: Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.
abstract: B cell chronic lymphocytic leukemia (CLL) CD38 expression is variable and may predict outcome. Inducible nitric oxide synthase (NOS2) expression regulates CLL cell apoptosis. IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression. We compared IL-4 and IFN-gamma serum levels between CLL patients and normal individuals, and determined whether serum IL-4 and IFN-gamma levels correlated with CLL cell CD38 expression and NOS enzyme activity. IL-4 levels, but not IFN-gamma levels, differed between normal individuals and CLL patients. Furthermore, there was an association of IL-4 levels, but not IFN-gamma levels, with CD38 and NOS2 expression in CLL patients.
authors.affiliation: Department of Medicine, Division of Rheumatology, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA. marc.levesque@duke.edu
authors.forename: Marc C
authors.initials: MC
authors.lastname: Levesque
authors.forename: Youwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Bethany E
authors.initials: BE
authors.lastname: Beasley
authors.forename: Charles W
authors.initials: CW
authors.lastname: O'Loughlin
authors.forename: Jon P
authors.initials: JP
authors.lastname: Gockerman
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Moore
authors.forename: J Brice
authors.initials: JB
authors.lastname: Weinberg
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000097:blood*; D000328:Adult; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood*; D008297:Male; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000097:blood*; D011379:Prognosis
chemical_list: D015847:Interleukin-4; D007371:Interferon-gamma; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D051997:ADP-ribosyl Cyclase 1