title: Lithium chloride: an active and simple catalyst for cyanosilylation of aldehydes and ketones.
abstract: LiCl acts as a highly effective catalyst for cyanosilylation of various aldehydes and ketones to the corresponding silylated cyanohydrins. The reaction proceeds smoothly with a substrate/catalyst molar ratio of 100-100,000 at 20-25 degrees C under solvent-free conditions. alpha,beta-Unsaturated aldehydes are completely converted to the 1,2-adducts. The cyanation products can be isolated by direct distillation of the reaction mixture.
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan.
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Kurono
authors.forename: Masayo
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohkuma