Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation.
The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.
Ravn
Lasse S
LS
Department of Medicine B2142, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hofman-Bang
Jacob
J
Dixen
Ulrik
U
Larsen
Severin Olesen
SO
Jensen
Gorm
G
Haunsø
Stig
S
Svendsen
Jesper Hastrup
JH
Christiansen
Michael
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics*; D018570:Risk Assessment
C489619:KCNE2 protein, human; D024642:Potassium Channels, Voltage-Gated