Failure of thromboprophylaxis in pregnancy caused by dual deficiencies of protein S and protein C.
Protein S and protein C deficiencies are commonly identified biochemical abnormalities associated with a hypercoagulable state; they result in an increased incidence of venous thromboembolism. We report the case of a pregnant woman with dual deficiencies of protein S and protein C, who encountered a venous thromboembolism 7 days postpartum despite of the use of danaparoid.
Morikawa
Mamoru
M
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Yamada
Hideto
H
Kato
Emi H
EH
Wada
Shinichiro
S
Suzuki
Shigenori
S
Sakuragi
Noriaki
N
Minakami
Hisanori
H
D000328:Adult; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D049590:Postpartum Period / Q000187:drug effects; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011292:Premedication; D020151:Protein C Deficiency / Q000150:complications; D018455:Protein S Deficiency / Q000150:complications; D013927:Thrombosis / Q000188:drug therapy / Q000517:prevention & control*; D017211:Treatment Failure; D020246:Venous Thrombosis / Q000209:etiology
D006493:Heparin