title: Eunicellin-based diterpenoids, australins A-D, isolated from the soft coral Cladiella australis.
abstract: The EtOAc extract of a Taiwanese soft coral, Caldiella australis, yielded four new eunicellin-based diterpenoids, australins A-D (1-4). The chemical structures of these metabolites were determined on the basis of extensive spectroscopic (including 1D and 2D NMR) analyses and by comparison of their NMR spectral data with those of related metabolites. Metabolite 2 was found to possess a moderate cytotoxic activity against selected breast and liver cancer cell lines.
authors.affiliation: Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Ming-Hsuan
authors.initials: MH
authors.lastname: Wu
authors.forename: Guey-Horng
authors.initials: GH
authors.lastname: Wang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C476503:eunicellin