title: Liver dysfunction in severe ovarian hyperstimulation syndrome.
abstract: We report the case of a 32-year-old woman suffering from severe liver dysfunction in the course of ovarian hyperstimulation syndrome (OHSS). Complications occurred after successful fertilization subsequent to ovarian stimulation with human menopausal gonadotropin followed by ovulation induction with human chorionic gonadotropin. Because of nausea, vomiting, abdominal distention and enlarged ovaries on an ultrasound examination, she was admitted on the diagnosis of OHSS. During the course of hospitalization severe hepatic injury developed. An increase of more than 100-fold in blood aminotransferase activity was observed. Applied treatment resulted in gradual reduction of ovarian size and resolution of ascites, as well as pleural and pericardial effusions. The patient was discharged from hospital after 46 days. Follow-up examinations at the 13th and 32nd weeks of gestation did not reveal any abnormalities. Pregnancy developed without complications and the woman went into spontaneous labor, giving birth to a viable child at 38 weeks' gestation. Taking into account the above case and previously published reports, the issue of liver dysfunction may have a great impact on the understanding both the pathology and the treatment of OHSS.
authors.affiliation: Department of Obstetrics and Gynecology, County Specialistic Hospital, Rzeszow, Poland.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Obrzut
authors.forename: Waldemar
authors.initials: W
authors.lastname: Kuczyński
authors.forename: Cezary
authors.initials: C
authors.lastname: Grygoruk
authors.forename: Lechosław
authors.initials: L
authors.lastname: Putowski
authors.forename: Sabina
authors.initials: S
authors.lastname: Kluz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Skret
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008596:Menotropins / Q000008:administration & dosage; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D010062:Ovulation Induction / Q000009:adverse effects; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D006063:Chorionic Gonadotropin; D008596:Menotropins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase