Sterically-controlled regioselective para-substitutions of aniline.
Introduction of sterically demanding 1-isopropyl-2-methylpropyl or triisopropylsilyl groups at the nitrogen of aniline allows high-yielding regioselective para-substitution to be achieved using a lithiation/substitution sequence.
Dyer
Philip W
PW
Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK. p.w.dyer@durham.ac.uk
Fawcett
John
J
Griffith
Gerald A
GA
Hanton
Martin J
MJ
Olivier
Céline
C
Patterson
Adam R
AR
Suhard
Samuel
S