[Outpatient diagnosis of oxidant stress in patients with carbohydrate metabolism disturbance in metabolic syndrome].
OBJECTIVE
To compare lipid peroxidation (LPO), (NO)-endothelium system in disorders of glucose tolerance (DGT) in patients with metabolic syndrome (MS) and diabetes mellitus type 2 (DM2).


METHODS
The trial included 178 patients with DGT and DM2 within MS (WHO, 1999). The control group consisted of 40 healthy subjects free of MS. Mean age of the examinees was 52.26 +/- 0.79 years. Four groups of patients were identified. Group 1--34 patients with DM2 running for 6.73 +/- 1.01 years; group 2--92 patients with newly diagnosed DM2; group 3--52 patients with DGT; group 4--healthy controls matched by sex and age. 139 (78.1%) females and 39 (21.9%) males had impaired carbohydrate metabolism. Measurements were made of blood pressure, fasting and postprandial glucose, HbA1c, total cholesterol, triglycerides, beta-lipoproteins, dienic conjugates, malonic dialdehyde in erythrocytes and blood plasm. NO-endothelium system was assessed by concentration of nitrate-ions in plasm and erythrocytes, count of circulating desquamated endotheliocytes (CDE).


RESULTS
A significant rise of LPO was seen depending on severity and duration of carbohydrate disbolism in all the patients compared to the controls. Concentration nitrate-ions of plasm and erythrocytes increases in newly diagnosed DM2 and DGT. In long-lasting DM2 NO3 in plasm and erythrocytes falls. Count of CDE elevates reaching maximum in DM2 running for 6.73 +/- 1.01 years.


CONCLUSIONS
MS patients at the stage of DGT demonstrate intensified LPO, elevated concentration of the end metabolites NO-nitrates and conditions for endotheliocytes desquamation. These processes promote early development of angiopathy in DM. DGT are reversible, therefore, these MS patients are perspective for prophylaxis. The presence of oxidant stress in such patients should be considered in prescription of relevant medication.
Romanenko
I A
IA
Poliatykina
T S
TS
Budnikova
N V
NV
Tomilova
I K
IK
Akaĭzin
E S
ES
Pakhrova
O A
OA
Arkhipova
S L
SL
D000553:Ambulatory Care; D050260:Carbohydrate Metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis*; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D016491:Peripheral Vascular Diseases / Q000209:etiology
D009569:Nitric Oxide