title: Role of mitochondria in the mechanisms of glutamate toxicity.
abstract: Current data on glutamate-induced functional and morphological changes in mitochondria correlating with or being a result of their membrane potential changes are reviewed. The important role of Ca2+, Na+, and H+ in the potentiation of such changes is considered. It is assumed that glutamate-induced loss of mitochondrial potential is mediated by Ca2+ overload resulting in the induction of nonspecific permeability of the inner mitochondrial membrane.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia. isaev@genebee.msu.su
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: N A
authors.initials: NA
authors.lastname: Andreeva
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D002118:Calcium / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D018846:Excitatory Amino Acids / Q000502:physiology*; D018698:Glutamic Acid / Q000633:toxicity*; D006706:Homeostasis; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010539:Permeability; D017470:Receptors, Glutamate / Q000187:drug effects / Q000378:metabolism
chemical_list: D018846:Excitatory Amino Acids; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D002118:Calcium