title: Contribution of retinal neurons to d-wave of primate photopic electroretinograms.
abstract: The purpose of this study was to determine the contribution of different types of retinal neurons to the d-wave of the primate electroretinogram using pharmacological agents. NMDA + TTX was used to suppress inner retinal activity, and APB and PDA to block the activity of the ON- and OFF-pathways, respectively. Results indicated that the inner retinal neurons had a small but certain contribution to the d-wave. The initial rapid phase of the d-wave originates from the activity of the cone OFF-pathway nearly exclusively, and the later slow phase is shaped by the cone photoreceptors. The cone ON-pathway acts in a direction opposite to that of the other components.
authors.affiliation: Department of Ophthalmology, Nagoya University School of Medicine, Showa-ku, Japan. ueno@med.nagoya-u.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Ueno
authors.forename: Mineo
authors.initials: M
authors.lastname: Kondo
authors.forename: Makiko
authors.initials: M
authors.lastname: Ueno
authors.forename: Kentaro
authors.initials: K
authors.lastname: Miyata
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
authors.forename: Yozo
authors.initials: Y
authors.lastname: Miyake
mesh_terms: D000613:Aminobutyrates; D000818:Animals; D004596:Electroretinography; D008253:Macaca mulatta; D016202:N-Methylaspartate; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D010875:Pipecolic Acids; D011323:Primates; D012160:Retina / Q000502:physiology*; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology; D013779:Tetrodotoxin; D014795:Visual Pathways / Q000502:physiology
chemical_list: D000613:Aminobutyrates; D010875:Pipecolic Acids; D013779:Tetrodotoxin; C029262:2,3-piperidinedicarboxylic acid; D016202:N-Methylaspartate; C012729:2-amino-4-phosphonobutyric acid