title: Differences in regional wash-in and wash-out time constants for xenon-CT ventilation studies.
abstract: Xenon-enhanced computed tomography (Xe-CT) has been used to measure regional ventilation by determining the wash-in (WI) and wash-out (WO) rates of stable Xe. We tested the common assumption that WI and WO rates are equal by measuring WO-WI in different anatomic lung regions of six anesthetized, supine sheep scanned using multi-detector-row computed tomography (MDCT). We further investigated the effect of tidal volume, image gating (end-expiratory EE versus end-inspiratory EI), local perfusion, and inspired Xe concentration on this phenomenon.
  
  
  RESULTS
  WO time constant was greater than WI in all lung regions, with the greatest differences observed in dependent base regions. WO-WI time constant difference was greater during EE imaging, smaller tidal volumes, and with higher Xe concentrations. Regional perfusion did not correlate with WI-WO. We conclude that Xe-WI rate can be significantly different from the WO rate, and the data suggest that this effect may be due to a combination of anatomic and fluid mechanical factors such as Rayleigh-Taylor instabilities set up at interfaces between two gases of different densities.
authors.affiliation: Departments of Radiology and Biomedical Engineering, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
authors.forename: Deokiee
authors.initials: D
authors.lastname: Chon
authors.forename: Brett A
authors.initials: BA
authors.lastname: Simon
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Beck
authors.forename: Hidenori
authors.initials: H
authors.lastname: Shikata
authors.forename: Osama I
authors.initials: OI
authors.lastname: Saba
authors.forename: Chulho
authors.initials: C
authors.lastname: Won
authors.forename: Eric A
authors.initials: EA
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008168:Lung / Q000502:physiology*; D008176:Lung Volume Measurements / Q000379:methods; D011651:Pulmonary Artery / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000502:physiology*; D015656:Respiratory Mechanics; D012756:Sheep; D013990:Tidal Volume / Q000502:physiology; D013997:Time Factors; D014018:Tissue Distribution / Q000502:physiology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014655:Vascular Resistance / Q000502:physiology; D014980:Xenon Radioisotopes / Q000493:pharmacokinetics
chemical_list: D014980:Xenon Radioisotopes