Plasma Proteome Database as a resource for proteomics research.
Plasma is one of the best studied compartments in the human body and serves as an ideal body fluid for the diagnosis of diseases. This report provides a detailed functional annotation of all the plasma proteins identified to date. In all, gene products encoded by 3778 distinct genes were annotated based on proteins previously published in the literature as plasma proteins and the identification of multiple peptides from proteins under HUPO's Plasma Proteome Project. Our analysis revealed that 51% of these genes encoded more than one protein isoform. All single nucleotide polymorphisms involving protein-coding regions were mapped onto the protein sequences. We found a number of examples of isoform-specific subcellular localization as well as tissue expression. This database is an attempt at comprehensive annotation of a complex subproteome and is available on the web at http://www.plasmaproteomedatabase.org.
Muthusamy
Babylakshmi
B
Institute of Bioinformatics, Bangalore, India.
Hanumanthu
G
G
Suresh
Shubha
S
Rekha
B
B
Srinivas
D
D
Karthick
L
L
Vrushabendra
B M
BM
Sharma
Salil
S
Mishra
Goparani
G
Chatterjee
Pritam
P
Mangala
K S
KS
Shivashankar
H N
HN
Chandrika
K N
KN
Deshpande
Nandan
N
Suresh
M
M
Kannabiran
N
N
Niranjan
Vidya
V
Nalli
Anuradha
A
Prasad
T S Keshava
TS
Arun
K S
KS
Reddy
Raghunath
R
Chandran
Sreenath
S
Jadhav
Trafina
T
Julie
D
D
Mahesh
M
M
John
S Lynate
SL
Palvankar
Kshitish
K
Sudhir
D
D
Bala
P
P
Rashmi
N S
NS
Vishnupriya
G
G
Dhar
Kaushik
K
Reshma
S
S
Chaerkady
Raghothama
R
Gandhi
T K B
TK
Harsha
H C
HC
Mohan
S Sujatha
SS
Deshpande
Krishna S
KS
Sarker
Malabika
M
Pandey
Akhilesh
A
D020816:Amino Acid Motifs; D001798:Blood Proteins / Q000737:chemistry* / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D030562:Databases, Protein; D015894:Genome, Human; D006801:Humans; D013058:Mass Spectrometry; D010455:Peptides / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms; D017434:Protein Structure, Tertiary; D040901:Proteomics / Q000379:methods*; D013997:Time Factors
D001798:Blood Proteins; D010455:Peptides; D020033:Protein Isoforms