title: Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction.
abstract: Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis-related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mizuno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Yozo
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Eiji
authors.initials: E
authors.lastname: Hishida
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kinjo
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nakatani
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shimizu
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kondo
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Kinya
authors.initials: K
authors.lastname: Otsu
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics* / Q000401:mortality; D011110:Polymorphism, Genetic; D011379:Prognosis; D012008:Recurrence; D015996:Survival Rate
chemical_list: D008233:Lymphotoxin-alpha