title: Structure, properties, and probable physiological role of small heat shock protein with molecular mass 20 kD (Hsp20, HspB6).
abstract: This review is devoted to critical analysis of data concerning the structure and functions of small heat shock proteins with apparent molecular mass 20 kD (Hsp20). We describe the structure of Hsp20, its phosphorylation by different protein kinases, interaction of Hsp20 with other small heat shock proteins, and chaperone activity of Hsp20. The distribution of Hsp20 in different animal tissues and the factors affecting expression of Hsp20 are also described. Data on the possible involvement of Hsp20 in regulation of platelet aggregation and glucose transport are presented and analyzed. Special attention is paid to literature data describing probable regulatory effect of Hsp20 on contraction of smooth muscle. Two hypotheses postulating direct effect of Hsp20 on actomyosin interaction or its effect on cytoskeleton are compared and analyzed. The most recent data on the effect of Hsp20 on apoptosis and contractile activity of cardiomyocytes are also presented.
authors.affiliation: Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia. NBGusev@mail.ru
authors.forename: N B
authors.initials: NB
authors.lastname: Gusev
authors.forename: O V
authors.initials: OV
authors.lastname: Bukach
authors.forename: S B
authors.initials: SB
authors.lastname: Marston
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050886:HSP20 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008970:Molecular Weight; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology; D032383:Myocytes, Cardiac / Q000502:physiology; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D010974:Platelet Aggregation / Q000502:physiology; D014018:Tissue Distribution
chemical_list: D050886:HSP20 Heat-Shock Proteins; C494382:HSPB6 protein, human; D006360:Heat-Shock Proteins; D010750:Phosphoproteins