title: Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland.
abstract: To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four out of 9 patients with residual disease (R2) are still alive. Median survival after metastasectomy was 78 and 52 months for R0 and R2 (p=0.4); median freedom from progression (FFP) in R0 and R2 groups was 30 and 15 months (p=0.2), respectively. A better outcome was obtained for patients with a disease-free interval 36 months and 6 metastases and bilateral involvement were critical in achieving a R0 intervention. Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC. However, if this could be translated into a survival benefit, it is still to be demonstrated.
authors.affiliation: Medical Oncology Unit/Head and Neck Unit, Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy. laura.locati@istitutotumori.mi.it
authors.forename: Laura D
authors.initials: LD
authors.lastname: Locati
authors.forename: Marco
authors.initials: M
authors.lastname: Guzzo
authors.forename: Paolo
authors.initials: P
authors.lastname: Bossi
authors.forename: Paolo P Brega
authors.initials: PP
authors.lastname: Massone
authors.forename: Barbara
authors.initials: B
authors.lastname: Conti
authors.forename: Elena
authors.initials: E
authors.lastname: Fumagalli
authors.forename: Claudia
authors.initials: C
authors.lastname: Bareggi
authors.forename: Giulio
authors.initials: G
authors.lastname: Cantù
authors.forename: Lisa
authors.initials: L
authors.lastname: Licitra
mesh_terms: D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000556:secondary / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008168:Lung / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms