title: Vision abnormalities in young children exposed prenatally to organic solvents.
abstract: Despite an accumulating body of evidence demonstrating that the visual system is an important target for organic solvent toxicity in adults, little attention has been paid to the visual functioning of children with prenatal exposure to organic solvents. The present study aimed to: (1) determine prospectively whether prenatal solvent exposure increases the risk of visual deficits in infants and (2) assess the relationship between estimates of exposure level and integrity of visual responses. A sample of 21 infants born to women who were occupationally exposed to solvents during pregnancy was compared with 27 non-exposed age-matched control infants. All mothers were recruited from Motherisk, an antenatal counseling service in Toronto, Canada. Contrast sensitivity and grating acuity were assessed using a sweep visual evoked potential (VEP) technique whereas chromatic- and achromatic mechanisms were assessed using a transient VEP technique. Exposure level was estimated from questionnaire data obtained during pregnancy. Testers were masked to exposure status. Results showed a significant reduction in contrast sensitivity in the low and intermediate spatial frequency range in solvent-exposed infants compared to controls (p<0.001). With respect to grating acuity, there was a significant effect of exposure level, with children in the high exposed having reduced grating acuity compared with children in the low exposed group (p<0.025) and controls (p=0.02). Regarding color vision, 26.3% of infants in the exposed group versus 0% of the controls produced abnormal VEP responses to the red-green onset stimulus (p<0.01), but not to either blue-yellow or achromatic stimuli. No differences were found with respect to latency or amplitude of chromatic and achromatic response. These findings suggest that prenatal solvent exposure is associated with selective visual deficits, including reduced contrast sensitivity and abnormal red-green vision. Increasing levels of exposure may lead to further visual deficits affecting grating acuity. These findings support the need for a re-evaluation of current occupational exposure standards for pregnant women.
authors.affiliation: Toronto Rehabilitation Institute, Toronto, Ont., Canada M5G 2A2. till.christine@torontorehab.on.ca
authors.forename: Christine
authors.initials: C
authors.lastname: Till
authors.forename: Carol A
authors.initials: CA
authors.lastname: Westall
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
authors.forename: Irena
authors.initials: I
authors.lastname: Nulman
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Rovet
mesh_terms: D000328:Adult; D002675:Child, Preschool; D015331:Cohort Studies; D003118:Color Perception / Q000187:drug effects; D015350:Contrast Sensitivity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004781:Environmental Exposure; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D016273:Occupational Exposure; D010775:Photic Stimulation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012030:Refractive Errors / Q000139:chemically induced / Q000453:epidemiology; D012684:Sensory Thresholds; D012997:Solvents / Q000009:adverse effects*; D014786:Vision Disorders / Q000139:chemically induced*; D014785:Vision, Ocular / Q000187:drug effects / Q000502:physiology
chemical_list: D012997:Solvents