Screening of Korean medicinal plants for lipase inhibitory activity.
The pancreatic lipase inhibitory activity of the aqueous ethanol extracts obtained from 19 medicinal plants was evaluated in vitro by a continuous-monitoring pH-Stat technique using tributyrin as a substrate. Of the extracts tested, those of Juniperus communis (bark) and Illicium religiosum (wood) exhibited the strongest activity with an IC50 value of 20.4 and 21.9 microg/mL, respectively.
Kim
Hye Young
HY
Food Function Research Division, Korea Food Research Institute, Kyonggi-do 463-746, Republic of Korea. khyey@kfri.re.kr
Kang
Mun Hui
MH
D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D029523:Illicium; D020128:Inhibitory Concentration 50; D018653:Juniperus; D007723:Korea; D008049:Lipase / Q000037:antagonists & inhibitors / Q000187:drug effects*; D008519:Medicine, Traditional; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D014934:Wood
D019440:Anti-Obesity Agents; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D008049:Lipase