Innate and adaptive immunity: the yin and yang of celiac disease.
Celiac disease is a multigenetic complex inflammatory disorder with an autoimmune component, induced by gluten, a protein found in wheat. It is a unique human disease model to dissect the innate and adaptive immune mechanisms underlying T-cell-mediated tissue destruction and the development of T-cell lymphoma in conditions of chronic T-cell activation.
Jabri
Bana
B
Department of Pathology, Medicine and Pediatrics, University of Chicago, Chicago, IL 60637, USA. bjabri@bsd.uchicago.edu
Kasarda
Donald D
DD
Green
Peter H R
PH
D001327:Autoimmune Diseases / Q000276:immunology*; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate