Paraneoplastic syndrome and intrathoracic Castleman disease.
We report two cases of intrathoracic Castleman disease presenting with paraneoplastic syndrome. Patient 1 was a 10-year-old girl with short stature. She was found to have delayed bone age, slow growth velocity, and iron-deficiency anemia, which was refractory to treatment. Thrombocytosis and hypergammaglobulinemia were later detected. Chest X-ray revealed a hilar mass. Patient 2 was a 14-year-old boy who had severe cough, progressive mucocutaneous erosion, and dermatitis. Chest X-ray showed a mediastinal mass. Sections of skin biopsy showed findings consistent with pemphigus disease. In each case, the histological diagnosis of Castleman disease was made.
Hung
Iou-Jih
IJ
Department of Medicine, Division of Hematology/Oncology, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan. wuhungij@ms37.hinet.net
Lin
Jainn-Jim
JJ
Yang
Chao-Ping
CP
Hsueh
Chuen
C
D000293:Adolescent; D000740:Anemia / Q000209:etiology; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D005076:Exanthema / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D019226:Oral Ulcer / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D010392:Pemphigus / Q000209:etiology; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome