title: A model for Rab GTPase localization.
abstract: The human genome encodes almost 70 Rab GTPases. These proteins are C-terminally geranylgeranylated and are localized to the surfaces of distinct membrane-bound compartments in eukaryotic cells. This mini review presents a working model for how Rabs achieve and maintain their steady-state localizations. Data from a number of laboratories suggest that Rabs participate in the generation of macromolecular assemblies that generate functional microdomains within a given membrane compartment. Our data suggest that these complex interactions are important for the cellular localization of Rab proteins at steady state.
authors.affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu
authors.forename: S
authors.initials: S
authors.lastname: Pfeffer
mesh_terms: D000818:Animals; D015894:Genome, Human; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D020691:rab GTP-Binding Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*
chemical_list: D020691:rab GTP-Binding Proteins