title: Concentrations of interleukin (IL)-1alpha, IL-1 soluble receptor type II (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra) in the peritoneal fluid and serum of infertile women with endometriosis.
abstract: OBJECTIVE
  Endometriosis is an immune system-related gynaecological disease, characterised by an increase in number and activation of peritoneal macrophages. One of macrophage-derived factors is interleukin (IL)-1. The effects of IL-1 are inhibited by IL-1 receptor type II (IL-1 RII), soluble forms of IL-1 RII (IL-1 sRII) and IL-1 receptor antagonist (IL-1 Ra). The aim of our work was to study the IL-1alpha, IL-1 sRII and IL-1 Ra levels in the peritoneal fluid (PF) and serum of women with endometriosis in relation to stage of disease.
  
  
  METHODS
  Concentrations of IL-1alpha, IL-1 sRII and IL-1 Ra were measured by ELISA assay in the PF and serum of 58 women; 43 with and 15 without endometriosis (control group).
  
  
  RESULTS
  Elevated PF and serum IL-1alpha and IL-1 Ra levels in the women with endometriosis in comparison with the control group were observed. IL-1 sRII levels in PF and serum were higher in the controls than in the women with endometriosis. Concentrations of IL-1alpha and IL-1 sRII were higher in advanced endometriosis, but higher IL-1 Ra was observed in the early stage of the disease.
  
  
  CONCLUSIONS
  Impairment of regulation IL-1 activity in the peritoneal fluid and serum of women with endometriosis may play an important role in the pathogenesis and development of the disease.
authors.affiliation: Department of Immunology and Serology, Silesian Medical Academy, Raciborska 15, 40-074 Katowice, Poland.
authors.forename: Zdzisława
authors.initials: Z
authors.lastname: Kondera-Anasz
authors.forename: Justyna
authors.initials: J
authors.lastname: Sikora
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Mielczarek-Palacz
authors.forename: Monika
authors.initials: M
authors.lastname: Jońca
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry; D004715:Endometriosis / Q000097:blood / Q000150:complications* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology*; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000032:analysis* / Q000097:blood; D010535:Laparoscopy; D017472:Receptors, Interleukin-1 / Q000032:analysis* / Q000097:blood; D053574:Receptors, Interleukin-1 Type II; D012795:Sialoglycoproteins / Q000032:analysis* / Q000097:blood
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D053574:Receptors, Interleukin-1 Type II; D012795:Sialoglycoproteins