An unusual transitory increase of lupus anticoagulant in dengue virus infection complicated with cerebral ischaemia.
Dengue is a common mosquito-transmitted viral disease prevalent at many undeveloped and developing countries. Although, neurological complication and hemostatic disturbance are common in dengue virus infection, cerebral ischaemia is barely mentioned. A 61-year-old woman experienced an acute onset of right hemiparesis in her early course of dengue virus type II infection. Extensive laboratory investigation revealed an increase of lupus anticoagulant activity and a prolonged activated partial thromboplastin time that were normalized in the convalescent stage. Her human leucocyte antigens were A2, A11, B8, Cw7, DR4 and DR9. This patient highlights the co-operation between transient activation of humoral immunity and preferential immunogenetic for coagulopathic thrombosis in specific viral disease.
Chen
Wei-Hsi
WH
Department of Neurology, Chang Gung Memorial Hospital, Niao Sung Hsiang, Kaohsiung 833, Taiwan, ROC. e49130@ms14.hinet.net
D002545:Brain Ischemia / Q000097:blood* / Q000473:pathology; D003715:Dengue / Q000097:blood*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008875:Middle Aged; D013997:Time Factors
D016682:Lupus Coagulation Inhibitor