title: Development of a safety index of transarterial chemoembolization for hepatocellular carcinoma to prevent acute liver damage.
abstract: BACKGROUND
  Transarterial chemoembolization (TACE) is the most effective palliative treatment for hepatocellular carcinoma (HCC), but may cause acute liver damage.
  
  
  METHODS
  One hundred and ninteen patients with unresectable HCCs, undergoing TACE, were studied prospectively. A safety index to prevent acute liver damage was developed by using logistic regression.
  
  
  RESULTS
  Acute liver damage by TACE was not related to the gender or age, but was mostly correlated to Child's classification (beta = 1.89, OR = 6.6, CI: 2.07, 21.01) and the amount of Lipiodol (beta = 0.09, OR = 1.09, CI: 1.02, 1.16) used for the TACE.
  
  
  CONCLUSIONS
  In treatment of a Child's B/C patient by TACE, no more than 20 ml Lipiodol should be used.
authors.affiliation: Department of Radiology, Taichung Veterans General Hospital, Taiwan, ROC.
authors.forename: Jen I
authors.initials: JI
authors.lastname: Hwang
authors.forename: Wai-Keung
authors.initials: WK
authors.lastname: Chow
authors.forename: Siu-Wan
authors.initials: SW
authors.lastname: Hung
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Cheng
authors.forename: Yung-Jen
authors.initials: YJ
authors.lastname: Ho
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D015251:Epirubicin / Q000008:administration & dosage; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D017114:Liver Failure, Acute / Q000209:etiology / Q000517:prevention & control*; D008113:Liver Neoplasms / Q000628:therapy*; D016015:Logistic Models; D011446:Prospective Studies
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin; D007459:Iodized Oil