title: [Effects of Guanyu capsule on the behavior and cerebral cortex monoamine neurotransmitters in depressive model of olfactory bulb damage rats].
abstract: OBJECTIVE
  To investigate the behavioral changes and the levels of monoamine neurotransmitters in the anterior cortex in the olfactory bulb damage rats after being treated with Guanyu capsules (GYC).
  
  
  METHODS
  Open-field test and step-down passive avoidance test were used to observe the behavior in model rats. HPLC-ECD was used to analyze the influences of GYC on the levels of monoamine neurotransmitters.
  
  
  RESULTS
  In the model rats, there was a characteristic hyperactivity in the Open-field and learning deficits in step-down passive avoidance (P < 0.01). The contents of 5-HT reduced, and the rate of DOPAC/DA increased significantly (P < 0.01). GYC 1.2, 0.6 g x kg(-1) could correct behavioral changes increase the contents of 5-HT, and decrease DOPAC/DA level (P < 0.01).
  
  
  CONCLUSIONS
  GYC can correct behavioral changes in rats model of olfactory bulb damage, and regulating 5-HT and DA metabolism in cortex is one of the antidepressive mechanisms of GYC.
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Jing-xia
authors.initials: JX
authors.lastname: Wang
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Gan-sheng
authors.initials: GS
authors.lastname: Zhong
authors.forename: De-qin
authors.initials: DQ
authors.lastname: Zhang
authors.forename: Su-min
authors.initials: SM
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Li-na
authors.initials: LN
authors.lastname: Ou
authors.forename: Xue-min
authors.initials: XM
authors.lastname: Gao
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D030024:Curcuma / Q000737:chemistry; D003863:Depression / Q000209:etiology / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D032492:Dryopteris / Q000737:chemistry; D008297:Male; D009830:Olfactory Bulb / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism
chemical_list: D015306:Biogenic Monoamines; D004365:Drugs, Chinese Herbal; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D004298:Dopamine