title: Habituation reduces novelty-induced FOS expression in the striatum and cingulate cortex.
abstract: Exposure to novel environments is known to induce c-fos expression in the cingulate cortex and dorsomedial striatum. This study examined the effects of 1, 3, and 7 days of exposure to sequential exposure to three novel environments. It was hypothesized that the ability of novel environment shuttling (NES) would induce c-fos expression as indicated by cells displaying FOS-like immunoreactivity (FLI) in the striatum and cingulate cortex which would decrease with repeated exposure. NES elicited FLI in both the cingulate cortex and striatum when compared to home-cage controls and this effect was attenuated with repeated exposure. Behavioral measures of activity decreased with repeated exposure suggesting that the decrease in FLI may be due to either a reduction in motor activity or increasing familiarity with the environments.
authors.affiliation: Psychology Department, Wheaton College, 501 East College Ave, Wheaton, IL 60187, USA. william.m.struthers@wheaton.edu
authors.forename: William M
authors.initials: WM
authors.lastname: Struthers
authors.forename: Aimee
authors.initials: A
authors.lastname: DuPriest
authors.forename: Jason
authors.initials: J
authors.lastname: Runyan
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002452:Cell Count / Q000379:methods; D003342:Corpus Striatum / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006179:Gyrus Cinguli / Q000378:metabolism*; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D016761:Oncogene Proteins v-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016761:Oncogene Proteins v-fos