'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants.
Novel water-soluble isopeptides of Abeta1-42 mutants, '26-O-acyl isoAbeta1-42 (26-AIAbeta42) mutants', which were efficiently converted to intact Abeta1-42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of Abeta1-42 mutants.
Sohma
Youhei
Y
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
Chiyomori
Yousuke
Y
Kimura
Maiko
M
Fukao
Fukue
F
Taniguchi
Atsuhiko
A
Hayashi
Yoshio
Y
Kimura
Tooru
T
Kiso
Yoshiaki
Y
D000215:Acylation; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis* / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000235:genetics; D012995:Solubility; D013997:Time Factors; D014867:Water / Q000737:chemistry
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D014867:Water