title: Sodium and calcium action potential in pituitary cells.
abstract: Several endocrine cells or their neoplastic derivatives generate action potentials similar to those seen in neurones, and in the adrenal chromaffin cell such regenerative potentials depend primarily on a sodium mechanism. Kidokoro has described action potentials in the GH3 rat pituitary cell line which seem to depend on a calcium mechanism. We have re-investigated the action potential in GH3 cells and found that it results from combined Na and Ca mechanisms in physiological conditions. In addition, we have recorded similar electrical excitability from two human pituitary tumours grown in vitro.
authors.affiliation: Department of Neurology and Pathology, beth Israel Hospital/Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: B
authors.initials: B
authors.lastname: Biales
authors.forename: M A
authors.initials: MA
authors.lastname: Dichter
authors.forename: A
authors.initials: A
authors.lastname: Tischler
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects; D002460:Cell Line; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D012964:Sodium; D002118:Calcium