title: Simultaneous onset of mitral regurgitation requiring surgery due to primary chordal rupture in middle-aged identical twins.
abstract: Primary chordal rupture is a leading cause of severe mitral regurgitation requiring surgery. It has previously been documented that there is a high probability of the occurrence of primary chordal rupture in patients with histological evidence of myxysomatous changes in the mitral valve. The precise etiology of primary chordal rupture and/or myxysomatous changes remains obscure and the relative contribution of genetic factors is debated. We report a pair of middle-aged identical twins requiring surgery for mitral regurgitation due to primary chordal rupture, and discuss the etiology of primary chordal rupture and/or myxysomatous changes.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Mieno
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Horimoto
authors.forename: Kunio
authors.initials: K
authors.lastname: Asada
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D002315:Cardiopulmonary Bypass; D002815:Chordae Tendineae / Q000000981:diagnostic imaging / Q000601:surgery*; D004200:Diseases in Twins; D004452:Echocardiography; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000601:surgery; D006341:Heart Rupture / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*