Messenger RNA surveillance: neutralizing natural nonsense.
Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.
Weischenfeldt
Joachim
J
Section of Gene Therapy Research, Copenhagen University Hospital, Juliane Mariesvej 20 section 9322, DK-2100 Copenhagen, Denmark. Joachim.weischenfeldt@rh.hosp.dk
Lykke-Andersen
Jens
J
Porse
Bo
B
D000818:Animals; D017173:Caenorhabditis elegans; D018389:Codon, Nonsense / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D011544:Pseudogenes / Q000235:genetics*; D020365:RNA Helicases / Q000378:metabolism; D020871:RNA Stability / Q000235:genetics / Q000502:physiology*; D020537:RNA, Small Nucleolar / Q000235:genetics*
D018389:Codon, Nonsense; D020537:RNA, Small Nucleolar; D020365:RNA Helicases