Synthesis of C4-modified acanthoic acid analogs and their biological evaluation as nitric oxide inhibitors.
Synthesis and biological evaluation of a series of C4-modified acanthoic acid analogs are reported. Among them, the analog 7 and 10 exhibit potent cellular inhibitory activity in NO inhibition assay.
Lee
Kwang-Ok
KO
College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Min
Kyung-Hoon
KH
Suh
Young-Ger
YG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000378:metabolism; D009573:Nitrites / Q000032:analysis; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D008070:Lipopolysaccharides; D009573:Nitrites; C099958:acanthoic acid; D009569:Nitric Oxide