title: The caregene study: muscle-specific creatine kinase gene and aerobic power in coronary artery disease.
abstract: In 927 biologically unrelated Caucasian patients with coronary artery disease it was investigated whether the NcoI restriction fragment length polymorphism of the muscle-specific creatine kinase (CKMM) gene is associated with aerobic power and with the response to physical training. Physical training significantly (P<0.001) increased peak oxygen consumption in the GG, AG and AA NcoI genotypes. Covariate-adjusted peak oxygen consumption at baseline, after training and the response to training were not different across CKMM NcoI genotypes.
authors.affiliation: Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, K.U. Leuven, Leuven, Belgium.
authors.forename: Johan
authors.initials: J
authors.lastname: Defoor
authors.forename: Kevin
authors.initials: K
authors.lastname: Martens
authors.forename: Gert
authors.initials: G
authors.lastname: Matthijs
authors.forename: Dominika
authors.initials: D
authors.lastname: Zieliñska
authors.forename: Dirk
authors.initials: D
authors.lastname: Schepers
authors.forename: Tim
authors.initials: T
authors.lastname: Philips
authors.forename: Robert
authors.initials: R
authors.lastname: Vlietinck
authors.forename: Robert
authors.initials: R
authors.lastname: Fagard
authors.forename: Luc
authors.initials: L
authors.lastname: Vanhees
mesh_terms: D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics*; D052283:Creatine Kinase, MM Form / Q000235:genetics*; D005080:Exercise Test; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D044465:White People
chemical_list: D052283:Creatine Kinase, MM Form