title: Cytotoxic activity of some natural and synthetic guaianolides.
abstract: Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.
authors.affiliation: Dipartimento di Chimica Organica, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy. bruno@dicpm.unipa.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.forename: Antonella
authors.initials: A
authors.lastname: Maggio
authors.forename: Rosa Angela
authors.initials: RA
authors.lastname: Raccuglia
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D017239:Paclitaxel / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C064339:repin; D017239:Paclitaxel