title: The effects of sevoflurane and hyperventilation on electrocorticogram spike activity in patients with refractory epilepsy.
abstract: We investigated the effects of sevoflurane and hyperventilation on intraoperative electrocorticogram (ECoG) spike activity in 13 patients with intractable epilepsy. Grid electrodes were placed on the brain surface and ECoG was recorded under the following conditions: 1) 0.5 minimal alveolar anesthetic concentration (MAC) sevoflurane, 2) 1.5 MAC sevoflurane, and 3) 1.5 MAC sevoflurane with hyperventilation. The number of spikes per 5 min and the percentage of leads with spikes were assessed in each condition. In 4 patients with chronically implanted-subdural electrodes, the leads with seizure onset and with spikes during the interictal periods in the awake state were compared with those during sevoflurane anesthesia at 0.5 MAC and 1.5 MAC. The number of spikes and the percentage of leads with spikes were significantly more under 1.5 MAC sevoflurane anesthesia compared with those under 0.5 MAC sevoflurane (P < 0.05). The induction of hyperventilation significantly increased the number of spikes and percentage of leads with spikes (P < 0.05). With 0.5 MAC sevoflurane, the leads with spikes were similar to those at seizure onset in the awake state, whereas with 1.5 MAC sevoflurane, spikes were similar to those occurring during interictal periods in the awake state. These results indicate that sevoflurane and hyperventilation can affect the frequency and extent of ECoG spike activity in patients with intractable epilepsy. Careful attention should be paid to the concentration of sevoflurane used and ventilatory status when intraoperative EcoG is used to localize epileptic lesions.
  
  
  CONCLUSIONS
  Electrocorticogram can be used to define the location and extent of epileptic foci during epilepsy surgery. However, electrocorticogram can be affected by anesthetic technique. The present study found that sevoflurane concentration and hyperventilation affected the frequency and the extent of electrocorticogram spike activity in epileptic patients.
authors.affiliation: Departments of *Anesthesiology and †Neurosurgery, Nara Medical University, Kashihara; ‡Department of Neurosurgery, Nara Prefectural Nara Hospital, Nara, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kurita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Tohru
authors.initials: T
authors.lastname: Hoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakase
authors.forename: Toshisuke
authors.initials: T
authors.lastname: Sakaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Furuya
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000927:Anticonvulsants / Q000627:therapeutic use; D001784:Blood Gas Analysis; D004351:Drug Resistance; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D000077149:Sevoflurane; D013696:Temperature
chemical_list: D018685:Anesthetics, Inhalation; D000927:Anticonvulsants; D008738:Methyl Ethers; D000077149:Sevoflurane