Isolation and characterization of 1,3-dicapryloyl-2-linoleoylglycerol: a novel triglyceride from berries of Hippophae rhamnoides.
1,3-Dicapryloyl-2-linoleoylglycerol (1), a novel triglyceride, was isolated from berries of Hippophae rhamnoides. The structure was elucidated on the basis of MS, 1D and 2D NMR experiments including HMQC and HMBC. The metal chelating, free radical scavenging, and lipid peroxidation inhibiting properties of the compound were also estimated with particular reference to radiation protection. In case of metal chelation and superoxide ion scavenging, 1 showed maximum inhibition at 50 microg/ml (11%) and 100 microg/ml (55%), respectively, whereas in lipid peroxidation, 1 showed maximum inhibition (57%) at 2 mg/ml as compared to quercetin as a control.
Swaroop
Anand
A
Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur, H.P.-176061, India.
Sinha
Arun Kumar
AK
Chawla
Raman
R
Arora
Rajesh
R
Sharma
Rakesh Kumar
RK
Kumar
Jonala Kotesh
JK
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002614:Chelating Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004075:Diglycerides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D031281:Hippophae / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C504499:1,3-dicapryloyl-2-linoleoylglycerol; D000975:Antioxidants; D002614:Chelating Agents; D004075:Diglycerides