title: Synthesis and cytotoxicity of novel sansalvamide A derivatives.
abstract: Described are the syntheses of 14 derivatives of the natural product Sansalvamide A, where two are more active against HCT 116 colon cancer cell lines than the natural product. These derivatives were synthesized using a combinatorial-type strategy that permits elucidation of the amino acid role in the cytotoxicity, and they lay the groundwork for development of new anticancer agents. [structure: see text]
authors.affiliation: Department of Chemistry, Molecular Biology Institute, and Center for Applied and Experimental Genomics, 5500 Campanile Road, 208 CSL, San Diego State University, San Diego, CA 92182-1030, USA.
authors.forename: Chris L
authors.initials: CL
authors.lastname: Carroll
authors.forename: Jennifer V C
authors.initials: JV
authors.lastname: Johnston
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kekec
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Brown
authors.forename: Emily
authors.initials: E
authors.lastname: Parry
authors.forename: Julia
authors.initials: J
authors.lastname: Cajica
authors.forename: Irene
authors.initials: I
authors.lastname: Medina
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Cook
authors.forename: Ricardo
authors.initials: R
authors.lastname: Corral
authors.forename: Po-Shen
authors.initials: PS
authors.lastname: Pan
authors.forename: Shelli R
authors.initials: SR
authors.lastname: McAlpine
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D047630:Depsipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C119376:sansalvamide A