Uterine tumour resembling an ovarian sex cord tumour.
Endometrial stromal sarcomas account for 0.25% of all uterine malignancies. These tumours were originally divided into low grade and high grade stromal sarcomas, but the recent World Health Organisation classification (2003) recognises low grade stromal sarcoma and undifferentiated endometrial sarcoma. Low grade sarcomas may exhibit other forms of differentiation, including smooth muscle and sex cord differentiation. In the latter form, the tumour contains epithelial-like or sex cord-like elements often with epithelioid appearance, arranged in nests, cords, trabeculae, solid, or tubular structures. If this element predominates, the tumour is considered to be a uterine tumour resembling ovarian sex cord tumour, and may cause diagnostic difficulties. This case report describes the histological and immunohistochemical features of a uterine stromal sarcoma showing exclusively a pattern reminiscent of ovarian sex cord tumour.
Sutak
J
J
Department of Pathology, Great Western Hospital, Marlborough Road, Swindon SN3 6BB, UK.
Lazic
D
D
Cullimore
J E
JE
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D015260:Neprilysin / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000473:pathology; D018203:Sarcoma, Endometrial Stromal / Q000378:metabolism / Q000473:pathology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D015260:Neprilysin