The role of optic nerve blood flow in the pathogenesis of glaucoma.
Many theories have surfaced regarding the exact mechanisms behind glaucomatous damage, but the complex nature of the disease and the inaccessibility of the internal structures of the human eye have limited current knowledge. Increased intraocular pressure is the risk factor most often associated with glaucomatous optic neuropathy; ischemic insult to the optic nerve has also been suggested as a possible cause of cellular damage. The aim of this review is to cover the possible role of optic nerve head hemodynamics in the pathogenesis of glaucoma.
Harris
Alon
A
Department of Ophthalmology, Room 137, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA. alharris@indiana.edu
Rechtman
Ehud
E
Siesky
Brent
B
Jonescu-Cuypers
Christian
C
McCranor
Lynne
L
Garzozi
Hana J
HJ
D000375:Aging / Q000502:physiology; D001783:Blood Flow Velocity; D001794:Blood Pressure; D005902:Glaucoma, Open-Angle / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D009898:Optic Disk / Q000098:blood supply*; D012039:Regional Blood Flow