Warfarin-induced leukocytoclastic vasculitis.
Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy.
Yaghoubian
Bahareh
B
Ambulatory Care Pharmacy, University of Southern California School of Pharmacy, Los Angeles, CA 90033, USA.
Ngo
Binh
B
Mak
May
M
Ostrzega
Enrique
E
Tesoro
Jane
J
Mitani
Gladys H Moriguchi
GH
D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced*; D014859:Warfarin / Q000009:adverse effects*
D000925:Anticoagulants; D014859:Warfarin