Vitamin B3 and sirtuin function.
Sirtuins are NAD(+)-dependent protein deacetylases that are involved in transcriptional regulation, metabolism, apoptosis, differentiation and ageing. These unique enzymes are inhibited by nicotinamide, which is a form of vitamin B3. Recent studies have uncovered the molecular basis for nicotinamide inhibition, and provided the framework to understand the physiological processes mediated by sirtuins and to develop strategies to modulate their cellular activity.
Denu
John M
JM
University of Wisconsin Medical School, Department of Biomolecular Chemistry, 1300 University Avenue, Madison, WI 53706, USA. jmdenu@wisc.edu
D000375:Aging / Q000502:physiology; D017209:Apoptosis; D002454:Cell Differentiation; D006801:Humans; D009536:Niacinamide / Q000502:physiology*; D037761:Sirtuins / Q000502:physiology*; D014158:Transcription, Genetic
D009536:Niacinamide; D037761:Sirtuins