Gaudichanolides A and B, clerodane diterpenes from Baccharis gaudichaudiana.
Two new clerodane diterpenoids, gaudichanolides A (1) and B (2), were isolated from the dried twigs of Baccharis gaudichaudiana, together with 7-oxo-16,19-dihydroxy-3,4-dehydroclerodan-15,20-diacid dilactone, spathulenol, 4,10-aromadendranediol, kobusone, trans-cosanyl ferulate, and defuscin. The structures and relative stereochemistry of 1 and 2 were elucidated by detailed 2D NMR spectroscopic experiments, and the absolute stereochemistry of 1 was determined by X-ray crystallographic analysis.
Hayashi
Ken-ichiro
K
Department of Biochemistry, Okayama University of Science, 1-1 Ridai-cho, Okayama City, 700-0005 Japan.
Kanamori
Takashi
T
Yamazoe
Atsushi
A
Yamada
Masashi
M
Nozaki
Hiroshi
H
D031175:Baccharis / Q000737:chemistry*; D001938:Brazil; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D045785:Diterpenes, Clerodane; C503033:gaudichanolide A; C503034:gaudichanolide B