title: In vivo pressure estimation using subharmonic contrast microbubble signals: proof of concept.
abstract: Changes in ambient pressure affects the reflectivity of ultrasound contrast microbubbles leading to an excellent correlation between subharmonic signals and hydrostatic pressure. The aortas of two dogs were scanned with an experimental pulse-echo system to validate in vivo pressure estimation based on subharmonic microbubble signals. Results matched well with instantaneous pressure measurements (from 20-60 mmHg) obtained simultaneously with a pressure catheter (root mean square errors <27%).
authors.forename: Flemming
authors.initials: F
authors.lastname: Forsberg
authors.forename: Ji-Bin
authors.initials: JB
authors.lastname: Liu
authors.forename: William T
authors.initials: WT
authors.lastname: Shi
authors.forename: Junji
authors.initials: J
authors.lastname: Furuse
authors.forename: Masafumi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Barry B
authors.initials: BB
authors.lastname: Goldberg
mesh_terms: D000465:Algorithms; D000818:Animals; D001011:Aorta / Q000000981:diagnostic imaging* / Q000502:physiology*; D001795:Blood Pressure Determination / Q000379:methods*; D003287:Contrast Media; D004285:Dogs; D004452:Echocardiography / Q000379:methods*; D005240:Feasibility Studies; D005290:Ferric Compounds; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007501:Iron; D045423:Microbubbles; D010087:Oxides; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D010087:Oxides; C069727:Sonazoid; D007501:Iron