title: In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata.
abstract: Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.
authors.affiliation: Department of General Dentistry, University of Texas Health Science Center at San Antonio, Mail Code 7914, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. oliveirae@uthscsa.edu
authors.forename: E R
authors.initials: ER
authors.lastname: Oliveira
authors.forename: A W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: W R
authors.initials: WR
authors.lastname: Kirkpatrick
authors.forename: B J
authors.initials: BJ
authors.lastname: Coco
authors.forename: T F
authors.initials: TF
authors.lastname: Patterson
authors.forename: S W
authors.initials: SW
authors.lastname: Redding
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D004357:Drug Synergism; D054714:Echinocandins; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests / Q000379:methods; D010456:Peptides, Cyclic / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D014230:Triazoles; C101425:posaconazole; D015725:Fluconazole; D000077336:Caspofungin