Phytochemical and pharmacological study of Sedum dendroideum leaf juice.
The fresh juice from leaves of Sedum dendroideum Moc & Sessé (Crassulaceae) is used in Brazilian traditional medicine for the treatment of gastric and inflammatory disorders. The present investigation was carried out to evaluate in vivo antinociceptive and anti-inflammatory activities of this plant material. The oral administration (0.1-1g/kg) of the lyophilized Sedum dendroideum juice (L J) caused a significant dose-related reduction of acetic acid-induced writhing response (ID(50)=631 mg/kg) and inhibited croton oil-induced ear oedema formation (66% inhibition at 1g/kg) in mice. In the formalin-induced nociception in mice, L J (1g/kg) only inhibited the second phase of nociception (46%). Phytochemical investigation revealed four known kaempferol glycosides, here, described at the first time for this species. These flavonoids probably explain the antinociceptive and anti-inflammatory effects of the fresh juice of Sedum dendroideum.
De Melo
Giany O
GO
Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21 941-590 Rio de Janeiro, RJ, Brazil.
Malvar
David do C
Ddo C
Vanderlinde
Frederico A
FA
Pires
Priscilla A
PA
Côrtes
Wellington S
WS
Filho
Pedro Germano
PG
Muzitano
Michelle F
MF
Kaiser
Carlos R
CR
Costa
Sônia S
SS
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000032:analysis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry*; D031963:Sedum / Q000737:chemistry*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005419:Flavonoids