Angiogenesis, vasculogenesis, and induction of healing in chronic wounds.
A key central stage of wound healing requires neovascularization of the wound base granulation tissue. In the adult, neovascularization is now known to occur by both angiogenesis and vasculogenesis. Understanding the biology of these 2 processes offers promising new therapeutic options for patients who suffer from chronic, nonhealing ischemic wounds. The authors review the current literature on the processes of angiogenesis and vasculogenesis and how it relates to wound healing.
Bauer
Stephen M
SM
University of Pennsylvania, Department of Surgery, Philadelphia, PA 19124, USA.
Bauer
Richard J
RJ
Velazquez
Omaida C
OC
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002454:Cell Differentiation; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D033581:Stem Cell Transplantation / Q000379:methods; D014647:Varicose Ulcer / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D043925:Angiogenesis Inducing Agents; D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins