title: Pulmonary sarcoidosis: comparison of findings of inspiratory and expiratory high-resolution CT and pulmonary function tests between smokers and nonsmokers.
abstract: OBJECTIVE
  The purpose of our study was to compare the high-resolution CT and pulmonary function test findings of smokers and nonsmokers with pulmonary sarcoidosis.
  
  
  METHODS
  Full inspiratory and expiratory high-resolution CT of the thorax and pulmonary function tests were performed in 46 patients (23 smokers and 23 lifelong nonsmokers) with histologically proven sarcoidosis. The median interval between high-resolution CT and pulmonary function tests was 8 days (range, 0-27 days). High-resolution CT findings were categorized into six patterns, and the overall extent of each pattern was scored independently (high-resolution CT score). Correlation between each high-resolution CT score with each pulmonary functional parameter was performed using Spearman's rank correlation and stepwise multiple regression analysis.
  
  
  RESULTS
  Air trapping on expiration (45/46 patients, 98%) and small nodules on inspiration (all 46 patients, 100%) were the most common findings. Smokers had a greater extent of emphysema than nonsmokers (p = 0.002). No significant difference was seen in the extent of air trapping, consolidation, ground-glass attenuation, reticular opacities, or small nodules between smokers and nonsmokers. On Spearman's rank correlation, the extent of air trapping negatively correlated with forced vital capacity in smokers (p < 0.05) but not in nonsmokers. The extent of small nodules negatively correlated with forced vital capacity and positively correlated with the ratio of forced expiratory volume in 1 sec to forced vital capacity in nonsmokers (p < 0.05, both) but not in smokers, respectively. On stepwise multiple regression analysis, the extent of air trapping on CT was independently associated with decreased forced vital capacity (p < 0.05), and cigarette smoking was the main determinant of decrease in maximum midexpiratory flow and forced expiratory flow at 50% of vital capacity (p < 0.01).
  
  
  CONCLUSIONS
  Cigarette smoking confounds the correlation between the CT and pulmonary function test findings in patients with sarcoidosis. Therefore, smoking history must be taken into account when correlating the extent of parenchymal sarcoidosis on CT with functional impairment.
authors.affiliation: Department of Radiology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan. terra@med.kurume-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Terasaki
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Nestor L
authors.initials: NL
authors.lastname: Müller
authors.forename: Junko
authors.initials: J
authors.lastname: Sadohara
authors.forename: Masafumi
authors.initials: M
authors.lastname: Uchida
authors.forename: Takeharu
authors.initials: T
authors.lastname: Koga
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
authors.forename: Naofumi
authors.initials: N
authors.lastname: Hayabuchi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012907:Smoking / Q000503:physiopathology; D014057:Tomography, X-Ray Computed