Prevalence of resistance mechanisms against macrolides and lincosamides in methicillin-resistant coagulase-negative staphylococci in the Czech Republic and occurrence of an undefined mechanism of resistance to lincosamides.
High occurrence of the non-macrolide-lincosamide-streptogramin B resistance genes msrA (53%) and linA/linA' (30%) was found among 98 methicillin-resistant coagulase-negative staphylococci additionally resistant to macrolides and/or lincosamides. The gene msrA predominated in Staphylococcus haemolyticus (43 of 62 isolates). In Staphylococcus epidermidis, it was present in 7 of 27 isolates. A novel mechanism of resistance to lincosamides appears to be present in 10 genetically related isolates of S. haemolyticus in the absence of ermA, ermC, msrA, and linA/linA'.
Novotna
Gabriela
G
Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 14220, Czechoslovakia.
Adamkova
Václava
V
Janata
Jiri
J
Melter
Oto
O
Spizek
Jaroslav
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D003030:Coagulase / Q000378:metabolism; D018153:Czech Republic / Q000453:epidemiology; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D015994:Incidence; D055231:Lincosamides; D018942:Macrolides / Q000494:pharmacology*; D026901:Membrane Transport Proteins / Q000235:genetics; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000145:classification / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003030:Coagulase; D055231:Lincosamides; D018942:Macrolides; D026901:Membrane Transport Proteins; C066202:msrA protein, Staphylococcus epidermidis