The Leptospira interrogans lexA gene is not autoregulated.
Footprinting and mutagenesis experiments demonstrated that Leptospira interrogans LexA binds the palindrome TTTGN(5)CAAA found in the recA promoter but not in the lexA promoter. In silico analysis revealed that none of the other canonical SOS genes is under direct control of LexA, making the leptospiral lexA gene the first described which is not autoregulated.
Cuñé
Jordi
J
Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Cullen
Paul
P
Mazon
Gerard
G
Campoy
Susana
S
Adler
Ben
B
Barbe
Jordi
J
D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D018983:DNA Footprinting; D004260:DNA Repair / Q000502:physiology; D006706:Homeostasis / Q000235:genetics*; D007921:Leptospira interrogans / Q000235:genetics*; D008969:Molecular Sequence Data; D016296:Mutagenesis; D012697:Serine Endopeptidases / Q000235:genetics*; D014158:Transcription, Genetic / Q000502:physiology; D000099160:LexA Repressor Protein
D001426:Bacterial Proteins; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein