title: Assessment of the efficacy of nonablative long-pulsed 1064-nm Nd:YAG laser treatment of wrinkles compared at 2, 4, and 6 months.
abstract: Rhytides represent an aesthetic problem for a large percentage of the population. Many methods, both noninvasive and invasive, have been used for the treatment of wrinkles. Recently, the long-pulsed 1064-nm Nd:YAG laser has been shown to enhance dermal collagen synthesis without damaging the epidermis. The purpose of this preliminary study is to evaluate the use of the long-pulsed Nd:YAG laser in the nonablative treatment of periocular and perioral wrinkles. Ten patients with facial wrinkles were treated with the long-pulsed 1064-nm Nd:YAG laser, at a spot size of 5 mm in diameter, energy density of 13 J/cm2, exposure time per pulse of 300 microseconds, and a repetition rate of 7 Hz. All patients had a total of three treatments, once every 2 weeks. Subjective (patient satisfaction index [SI]) and objective (both physician- and computer program-based clinical index [CI]) assessments were performed before the first and third treatment sessions, and at 2, 4, and 6 months after the last treatment. At 6 months after the final treatment session, the patients' subjective SI was maintained at 40%, and had peaked at 50% 2 months after the final session. Physician assessment showed a CI of 40% at the 6-month assessment point and the computer program showed a 50% CI. The greatest level of effect with long-pulsed Nd:YAG laser nonablative skin rejuvenation for facial wrinkles was seen 2 months after the final treatment. Effects were still visible at the 6-month period, but showed a tendency to decrease. Maintenance treatments are required to achieve good patient satisfaction.
authors.affiliation: Instituto Médico Vilafortuny /Antoni De Gimbernat Foundation, Cambrils, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Trelles
authors.forename: X
authors.initials: X
authors.lastname: Alvarez
authors.forename: M J
authors.initials: MJ
authors.lastname: Martín-Vázquez
authors.forename: O
authors.initials: O
authors.lastname: Trelles
authors.forename: M
authors.initials: M
authors.lastname: Velez
authors.forename: J L
authors.initials: JL
authors.lastname: Levy
authors.forename: I
authors.initials: I
authors.lastname: Allones
mesh_terms: D000328:Adult; D000538:Aluminum Silicates; D062109:Dermatologic Surgical Procedures; D004890:Erythema / Q000209:etiology; D005145:Face / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017075:Laser Coagulation / Q000295:instrumentation / Q000379:methods*; D007834:Lasers / Q000145:classification; D008297:Male; D008875:Middle Aged; D009354:Neodymium; D010149:Postoperative Pain / Q000209:etiology; D017060:Patient Satisfaction; D010781:Photography; D012060:Rejuvenation; D012867:Skin / Q000473:pathology; D015595:Skin Aging / Q000473:pathology*; D012984:Software; D016896:Treatment Outcome; D015019:Yttrium
chemical_list: D000538:Aluminum Silicates; D009354:Neodymium; D015019:Yttrium