Synthesis of cell-penetrating peptides for cargo delivery.
Cell-penetrating peptides (CPPs) have served as vehicles for the delivery of different molecules and particles into cells. The efficiency and noninvasive nature of peptide-mediated cellular transduction provides a promising tool for biomedical research. Studies of cell-penetrating constructs that deliver oligonucleotides, peptides, and proteins have elucidated several important cellular signaling mechanisms. Here we briefly describe the major classes of cell-penetrating peptides. We also present various strategies used to couple different cargoes to CPPs.
Pooga
Margus
M
Estonian Biocentre, Tartu.
Langel
Ulo
U
D000595:Amino Acid Sequence; D000818:Animals; D002477:Cells / Q000378:metabolism; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015195:Drug Design; D066298:In Vitro Techniques; D008967:Molecular Biology / Q000379:methods; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics
D004337:Drug Carriers; D010455:Peptides