[Effects of glyprolines on development and healing of acetate ulcers in rats].
We studied glyprolines influence on development and healing of acetate ulcers in rats. A maximal ulcer area has developed four days after application of acetic acid to gastric serous mucosa. Estimation of ulcer area in the control and experimental animals receiving a physiological solution or peptides was carried out on day 4 or 7 after ulcerogenesis. Single administration of PGP, PG or GP in an equimolar dose of 3.7 mcmol/kg (i/p) during 1-3 days after the application significantly reduced ulcers by 88%, 93% and 94%, respectively, compared to the controls. Administration of these peptides for 4-6 days after application led to a significant reduction of the lesions by 46,50 and 96%, respectively, vs controls. Thus, glyprolines inhibit development of acetic ulcers and enhance their healing.
Bakaeva
Z V
ZV
Samonina
G E
GE
D000085:Acetates / Q000009:adverse effects; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000085:Acetates; D004151:Dipeptides; D009842:Oligopeptides; D010455:Peptides; C113164:prolyl-glycyl-proline; C057749:prolylglycine; C015248:glycylproline; D011392:Proline