title: Usefulness of serum endothelin levels in predicting death and myocardial infarction but not coronary progression in postmenopausal women with coronary disease (from the Women's Angiographic Vitamin and Estrogen [WAVE] study).
abstract: We performed a cohort study of 392 postmenopausal women who had coronary disease to assess whether baseline serum endothelin-1 level predicts angiographic disease progression, nonfatal myocardial infarction, or death. Angiographic progression was defined as the annualized change in minimal lumen diameter of all qualifying lesions for each patient. Twenty-nine patients died or had a myocardial infarction during follow-up. Each picogram per milliliter increase in endothelin-1 was associated with a 1.8-fold increased risk of death or myocardial infarction. After adjustment for potential confounders, endothelin-1 remained a predictor of clinical events but was not correlated with angiographic progression.
authors.affiliation: Division of General Internal Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Bernice
authors.initials: B
authors.lastname: Ruo
authors.forename: Mark T
authors.initials: MT
authors.lastname: Tripputi
authors.forename: Priscilla Y
authors.initials: PY
authors.lastname: Hsue
authors.forename: Masahiko
authors.initials: M
authors.lastname: Saigo
authors.forename: Pamela
authors.initials: P
authors.lastname: Ouyang
authors.forename: David D
authors.initials: DD
authors.lastname: Waters
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D018450:Disease Progression; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging; D017698:Postmenopause; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic
chemical_list: D015415:Biomarkers; D019332:Endothelin-1