title: Topical budesonide for treating giant rectal pseudopolyposis.
abstract: Pseudopolyps are a frequent finding in the course of inflammatory bowel disease. They are non-neoplastic lesions resulting from a regenerative and healing process that leaves inflamed colonic mucosa in polypoid configuration. Data about their management is lacking. "Giant" pseudopolyps can be mistaken for adenocarcinomas and, as they rarely regress with medical management alone, a surgical resection is often required. A case ofgiantpseudopolyposis treated non-surgically, in a patient with concomitant ulcerative colitis and chronic hepatitis B, is reported, representing a co-morbidity complicating an eventual conservative treatment. The clinical implementation of topical budesonide was originally tested, resulting in clinical, endoscopic and histological remission. Budesonide seems a promising therapy for IBD, particularly when a comorbidity with viral hepatitis exist.
authors.affiliation: First Department of Internal Medicine, Sismanogleion Hospital, Athens, Greece. hpilichos@hotmail.com
authors.forename: Charalampos
authors.initials: C
authors.lastname: Pilichos
authors.forename: Athena
authors.initials: A
authors.lastname: Preza
authors.forename: Maria
authors.initials: M
authors.lastname: Demonakou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kapatsoris
authors.forename: Constantinos
authors.initials: C
authors.lastname: Bouras
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D019819:Budesonide / Q000008:administration & dosage*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000473:pathology; D007417:Intestinal Polyps / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012002:Rectal Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D019819:Budesonide