title: Are factor V and prothrombin mutations associated with increased risk of oral cancer?
abstract: BACKGROUND
  Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore, a search for a similar association of other thrombosis-related factors with oral cancer is justified.
  
  
  METHODS
  In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy controls.
  
  
  RESULTS
  Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia (p < 0.001).
  
  
  CONCLUSIONS
  There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in oncogenesis in the oral region.
authors.affiliation: Department of Maxillofacial Surgery, University of Athens Medical School, Vas. Sofias 93 & Dim. Soutsou 1, Athens, Greece.
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Vairaktaris
authors.forename: Christos
authors.initials: C
authors.lastname: Yapijakis
authors.forename: Jörg
authors.initials: J
authors.lastname: Wiltfang
authors.forename: Jutta
authors.initials: J
authors.lastname: Ries
authors.forename: Antonis
authors.initials: A
authors.lastname: Vylliotis
authors.forename: Spyridoula
authors.initials: S
authors.lastname: Derka
authors.forename: Stavros
authors.initials: S
authors.lastname: Vasiliou
authors.forename: Friedrich W
authors.initials: FW
authors.lastname: Neukam
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000235:genetics*; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000097:blood / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin