title: Distributed neural actions of anti-parkinsonian therapies as revealed by PET.
abstract: There is a limited understanding of how different anti-parkinsonian treatments act at the neuronal systems level. Using positron emission tomography we examined the effects of levodopa and deep brain stimulation of the subthalamic nucleus on patterns of regional cerebral blood flow in patients with Parkinson's disease during a homogenous cognitive-behavioural state rather than during an unspecified resting state. We found that when medicated precuneus, frontal, parietal, cerebellar and midbrain areas were relatively more activated than when stimulated, whereas when stimulated the precentral gyrus, caudate and thalamus were relatively more activated than when medicated. Areas that were activated by both treatments included the temporal gyri, anterior thalamus, and midbrain. Regions of prefrontal cortex showed relatively greater activation in the "off treatment" conditions of both the medicated and stimulated groups. Our findings suggest that the two treatment methods may lead to symptomatic relief via both common and different sites of action.
authors.affiliation: MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom.
authors.forename: I K
authors.initials: IK
authors.lastname: Goerendt
authors.forename: A D
authors.initials: AD
authors.lastname: Lawrence
authors.forename: M A
authors.initials: MA
authors.lastname: Mehta
authors.forename: J S
authors.initials: JS
authors.lastname: Stern
authors.forename: P
authors.initials: P
authors.lastname: Odin
authors.forename: D J
authors.initials: DJ
authors.lastname: Brooks
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000378:metabolism / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D015331:Cohort Studies; D046690:Deep Brain Stimulation; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa