title: Sildenafil increases cerebrovascular reactivity: a transcranial Doppler study.
abstract: The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.
authors.affiliation: Fondazione Santa Lucia IRCCS, Rome, Italy. marina.diomedi@uniroma2.it
authors.forename: M
authors.initials: M
authors.lastname: Diomedi
authors.forename: F
authors.initials: F
authors.lastname: Sallustio
authors.forename: B
authors.initials: B
authors.lastname: Rizzato
authors.forename: F
authors.initials: F
authors.lastname: Ferrante
authors.forename: G
authors.initials: G
authors.lastname: Leone
authors.forename: E
authors.initials: E
authors.lastname: Spera
authors.forename: M
authors.initials: M
authors.lastname: Scarfini
authors.forename: G
authors.initials: G
authors.lastname: Bernardi
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000139:chemically induced / Q000503:physiopathology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000139:chemically induced / Q000503:physiopathology; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D010919:Placebos; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D010919:Placebos; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate