title: Intravenous administration of Gd-DTPA prior to DWI does not affect the apparent diffusion constant.
abstract: MRI measurements of water diffusion and blood perfusion are increasingly used for the evaluation of organ functionality and tissue viability (e.g., in tumors). While diffusion-weighted imaging is performed without contrast agents, measurement of blood perfusion is normally performed based on the administration of paramagnetic substances such as gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA). Simultaneous measurements of these two parameters are often preferred. However, it may be argued that Gd-DTPA causes constriction of small blood vessels or alters hemodynamic parameters such as blood viscosity, thereby corrupting subsequent measurements of the apparent diffusion constant (ADC). The objective of the current study was to investigate the possible changes in the ADC in tumors following intravenous administration of 0.2 and 0.4 mmol/kg of Gd-DTPA in mice. The study was conducted with C3H mouse mammary carcinomas inoculated in the right foot of the animal subjects. The results were compared with findings in a sham group, demonstrating that Gd-DTPA had no significant impact on the ADC as measured in a 7-T animal system.
authors.affiliation: MR Research Center, Aarhus University Hospital, Aarhus, DK8200 Aarhus N, Denmark. gangchen@mr.au.dk
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Sune Nørhøj
authors.initials: SN
authors.lastname: Jespersen
authors.forename: Michael
authors.initials: M
authors.lastname: Pedersen
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
authors.forename: Michael R
authors.initials: MR
authors.lastname: Horsman
authors.forename: Hans
authors.initials: H
authors.lastname: Stødkilde-Jørgensen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D015674:Mammary Neoplasms, Animal / Q000098:blood supply*; D051379:Mice; D009368:Neoplasm Transplantation
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA