title: Elevated TFPI levels in female hyperhomocysteinemic patients.
abstract: OBJECTIVE
  Hyperhomocysteinemia is a risk factor for cardiovascular diseases, while tissue factor pathway inhibitor (TFPI) regulates the extrinsic pathway of blood coagulation. We investigated the in vivo influence of elevated homocysteine concentrations on TFPI levels.
  
  
  METHODS
  Total TFPI levels of 82 hyperhomocysteinemic patients were determined.
  
  
  RESULTS
  The patients' TFPI levels were significantly elevated compared to blood donors, with a more pronounced effect in females than in males.
  
  
  CONCLUSIONS
  We have shown a gender-dependent TFPI elevation in hyperhomocysteinemic patients.
authors.affiliation: Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
authors.forename: Elmar
authors.initials: E
authors.lastname: Thyzel
authors.forename: Sabine
authors.initials: S
authors.lastname: Siegling
authors.forename: Christian
authors.initials: C
authors.lastname: Götting
authors.forename: Knut
authors.initials: K
authors.lastname: Kleesiek
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013923:Thromboembolism / Q000097:blood / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D015415:Biomarkers; D008074:Lipoproteins; D014280:Triglycerides; C051928:lipoprotein-associated coagulation inhibitor; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine