Endometrial cancer: population attributable risks from reproductive, familial and socioeconomic factors.
In this study, based on the Swedish Family-Cancer Database, risk factors and their population attributable fractions (PAFs) for endometrial cancer were studied. Over 700,000 women at ages 51-68 years, accumulating 23 million person-years at risk, were entered into Poisson analysis. Overall, reproductive factors (parity and age at last birth) showed a relative risk (RR) of 1.91 and a PAF of 45.51% when the reference group was women with a parity of 3+ and the last childbirth at ages over 34 years. The RR for family history was 2.33 but the PAF was only 2.09%. The RR for socioeconomic factors was a modest 1.12 but the PAF was 6.34%. The combined PAF of these three types of risk factors was 51.84%. Although the present analysis lacked data on some important risk factors for endometrial cancer, the results suggest that a large proportion of the etiology of endometrial cancer can be defined by known epidemiological risk factors.
Hemminki
Kari
K
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. K.Hemminki@dkfz.de
Bermejo
Justo Lorenzo
JL
Granström
Charlotta
C
D000368:Aged; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D008423:Maternal Age; D008875:Middle Aged; D010298:Parity; D010375:Pedigree; D016012:Poisson Distribution; D011247:Pregnancy; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012959:Socioeconomic Factors; D013548:Sweden / Q000453:epidemiology