title: A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methods.
abstract: This article is a report of the design and methods of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. This longitudinal, population-based study was initiated to investigate the genetic determinants of cardiovascular disease and its risk factors. Between October 2000 and April 2004, this family study enrolled 1,214 Eskimos from several coastal villages in the Norton Sound region of Western Alaska. Examinations included a physical, laboratory determinations, and measures of subclinical disease. This study will generate a genome-wide scan for loci influencing cardiovascular disease-related traits. Relations between subclinical atherosclerosis and markers of inflammation will be examined using historic and newly drawn samples. The study will provide data on CVD prevalence, risk factors and the relative contribution of genetic and environmental determinants in Alaska Native peoples. Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations.
authors.affiliation: MedStar Research Institute, Washington, DC, USA. Barbara.v.howard@medstar.net
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Richard B
authors.initials: RB
authors.lastname: Devereux
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Michael
authors.initials: M
authors.lastname: Davidson
authors.forename: Bennett
authors.initials: B
authors.lastname: Dyke
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Epstein
authors.forename: David R
authors.initials: DR
authors.lastname: Robinson
authors.forename: Betty
authors.initials: B
authors.lastname: Jarvis
authors.forename: David J
authors.initials: DJ
authors.lastname: Kaufman
authors.forename: Sandra
authors.initials: S
authors.lastname: Laston
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.forename: Peter M
authors.initials: PM
authors.lastname: Okin
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Roman
authors.forename: Terry
authors.initials: T
authors.lastname: Romenesko
authors.forename: Giacomo
authors.initials: G
authors.lastname: Ruotolo
authors.forename: Michael
authors.initials: M
authors.lastname: Swenson
authors.forename: Charlotte R
authors.initials: CR
authors.lastname: Wenger
authors.forename: Sarah
authors.initials: S
authors.lastname: Williams-Blangero
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhu
authors.forename: Clarence
authors.initials: C
authors.lastname: Saccheus
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: David C
authors.initials: DC
authors.lastname: Robbins
mesh_terms: D000328:Adult; D000368:Aged; D000413:Alaska / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000208:ethnology* / Q000235:genetics*; D015340:Epidemiologic Research Design; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D005838:Genotype; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D004930:Inuit; D008019:Life Style / Q000208:ethnology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011159:Population Surveillance / Q000379:methods; D012307:Risk Factors
chemical_list: D018836:Inflammation Mediators