[Effect of heptral and folic acid on the hepatic functions during toxic hepatitis].
The aim of study was to evaluate effectiveness of heptral (S-Adonosylmethionine-Adomet) and folic acid during the acute toxic damage of the liver induced by carbon tetrachloride. Experiments have been carried out on pubertal rats. The carbon tetrachloride intoxication was performed by subcutaneous injection of CCL(4) 1 ml/kg dissolved in 1 ml of olive oil. The activity of aspartat-and alaninaminotransferases, alkaline phosphatase, the content of free and total billirubine in the blood, as well as total oxidant and antioxidant activity of the blood, were measured by the spectrophotometric techniques. Oxidative stress, cytolyses of the hepatocytes and cholestasis were observed during CCL(4) intoxication. Heptral, and in less degree, folic acid improved liver function during the acute toxic damage, but complex therapy with heptral and folic acid revealed more expressive hepatoprotective effect. It is suggested that better positive effect of complex therapy with heptral and folic acid compared with monotherapy by each drug is probably associated with resynthesis of methionine from homocystein (toxic metabolite of adenosylmethionine) by folate. This combination allows reducing the side effects of heptral induced by homocysteine.
Gogolauri
M I
MI
Department of Pharmacology, Tbilisi State Medical University, Georgia.
Antelava
N A
NA
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005492:Folic Acid / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012436:S-Adenosylmethionine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D012436:S-Adenosylmethionine; D005492:Folic Acid