title: A common pathway for intracellular reactive oxygen species production by glycoxidative and nitroxidative stress in vascular endothelial cells and smooth muscle cells.
abstract: A large body of evidence suggests that carbonyl compounds induce intracellular signaling by increasing oxidative stress in the cell; however, the mechanisms involved have not been fully described. The focus of our research is on the pathway in which antioxidative enzymes are modified and inactivated by carbonyl compounds, resulting in the accumulation of active oxygen species in the cell. A common pathway appears to exist for cellular signaling evoked by nitroxidative stress. It could be concluded that some glycoxidative stress and nitroxidative stress cause intracellular signaling via similar mechanisms. The elucidation of the pathway for extracellular stress-induced reactive oxygen species (ROS) production would be important for our understanding of the role of ROS as signaling molecules.
authors.affiliation: Department of Biochemistry, Osaka University Graduate School of Medicine, B1, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. proftani@biochem.med.osaka-u.ac.jp
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Taniguchi
authors.forename: Motoko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sakiyama
authors.forename: Yong Seek
authors.initials: YS
authors.lastname: Park
authors.forename: Michio
authors.initials: M
authors.lastname: Asahi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Misonou
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003847:Deoxyglucose / Q000493:pharmacokinetics; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D009130:Muscle, Smooth / Q000502:physiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011765:Pyruvaldehyde / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014471:Umbilical Veins / Q000187:drug effects / Q000502:physiology
chemical_list: D017382:Reactive Oxygen Species; D011765:Pyruvaldehyde; D003847:Deoxyglucose