title: Highly enantioselective synthesis of fluorinated gamma-amino alcohols through proline-catalyzed cross-Mannich reaction.
abstract: A new, simple route for the synthesis of fluorinated beta-alkyl gamma-amino alcohols in optically pure form in only two steps and featuring proline catalysis from inexpensive and readily available starting materials is described. The applied strategy allows for the introduction of diversity into both the beta-fluoroalkyl and alpha-alkyl groups of these compounds. [reaction: see text]
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain.
authors.forename: Santos
authors.initials: S
authors.lastname: Fustero
authors.forename: Diego
authors.initials: D
authors.lastname: Jiménez
authors.forename: Juan F
authors.initials: JF
authors.lastname: Sanz-Cervera
authors.forename: María
authors.initials: M
authors.lastname: Sánchez-Roselló
authors.forename: Elisabet
authors.initials: E
authors.lastname: Esteban
authors.forename: Antonio
authors.initials: A
authors.lastname: Simón-Fuentes
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D006845:Hydrocarbons, Fluorinated; D008352:Mannich Bases; D011392:Proline