[Study on preparation of refined Xiong-gui sustained release pills].
OBJECTIVE
To optimize the molding formula of refined Xiong-gui sustained release pills, types and assorted dosages of water-soluble and non water-soluble drug carrier were studied.


METHODS
An orthogonal design was performed to sift the pill formulation. The processing conditions were determining in terms of roundness, hardness, viscosity, fluidity, easily drop.


CONCLUSIONS
According to the final optimal formula, the amount of drug release can be detected instantly, while remaining over 80% at 10 h.
Li
Hui
H
Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. lihuiyiren@sina.com
Bian
Bao-lin
BL
Meng
Fan-yun
FY
Wang
Yi-tao
YT
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000032:analysis; D029971:Angelica sinensis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D030004:Ligusticum / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C027820:ligustilide; D015107:4-Butyrolactone