Nitrite mitigates lipid peroxidation in rat gastric mucosa.
Sodium nitrite, a nitric oxide (NO) donor in the acid pH, has been found to mitigate lipid peroxidation in rat gastric mucosa, and it elevated both Cu, Zn- and Mn-forms of the superoxide dismutase in this tissue. Putrescine, a simple polyamine of anti-oxidant properties has been shown to normalize lipid peroxidation levels in nitrite-treated animals.
Grudziński
Ireneusz P
IP
Department of Applied Physiology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.
Frankiewicz-Jóźko
Anna
A
Szarska
Ewa
E
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011700:Putrescine / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism*
D000975:Antioxidants; D013482:Superoxide Dismutase; D012977:Sodium Nitrite; D011700:Putrescine