title: The incidence of herpes zoster in a United States administrative database.
abstract: BACKGROUND
  Few recent studies have reported data on the incidence of herpes zoster (HZ) in U.S. general clinical practice.
  
  
  OBJECTIVE
  To estimate the age- and sex-specific incidence of HZ among U.S. health plan enrollees.
  
  
  METHODS
  Data for the years 2000 to 2001 were obtained from the Medstat MarketScan database, containing health insurance enrollment and claims data from over 4 million U.S. individuals. Incident HZ cases were identified through HZ diagnosis codes on health care claims. The burden of HZ among high-risk individuals with recent care for cancer, HIV, or transplantation was examined in sub-analyses. Overall incidence rates were age- and sex-adjusted to the 2000 U.S. population.
  
  
  METHODS
  MarketScan U.S. health plan enrollees of all ages.
  
  
  RESULTS
  We identified 9,152 incident cases of HZ (3.2 per 1,000 person-years) (95% confidence interval [CI], 3.1 to 3.2 per 1,000). Annual HZ rates per 1,000 person-years were higher among females (3.8) than males (2.6) (P<.0001). HZ rates rose sharply with age, and were highest among individuals over age 80 (10.9 per 1,000 person-years) (95% CI, 10.2 to 11.6). The incidence of HZ per 1,000 person-years among patients with evidence of recent care for transplantation, HIV infection, or cancer (10.3) was greater than for individuals without recent care for these conditions (3.0) (P<.0001).
  
  
  CONCLUSIONS
  The overall incidence of HZ reported in the present study was found to be similar to rates observed in U.S. analyses conducted 10 to 20 years earlier, after age- and sex-standardizing estimates from all studies to the 2000 U.S. population. The higher rate of HZ in females compared with males contrasts with prior U.S. studies.
authors.affiliation: Department of Health Economic Statistics, Merck Research Laboratories, Blue Bell, PA, USA. ralph_insinga@merck.com
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Insinga
authors.forename: Robbin F
authors.initials: RF
authors.lastname: Itzler
authors.forename: James M
authors.initials: JM
authors.lastname: Pellissier
authors.forename: Patricia
authors.initials: P
authors.lastname: Saddier
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Nikas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D016208:Databases, Factual; D005260:Female; D006562:Herpes Zoster / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D014481:United States / Q000453:epidemiology