[Roles of glial cell line-derived neurotropic factor in motoneuron development and motoneuron disease].
OBJECTIVE
To review research progress of the relation between glial cell line-derived neurotropic factor (GDNF) and motor neuron development and motor neuron disease.


METHODS
The recent articles on GDNF and motor neurons were extensively reviewed. The molecular structure, the mode of action and the route of administration of GDNF were investigated.


RESULTS
GDNF plays extensive roles in the development and disease of motor neuron. GDNF might regulate the development of the motor neurons of the spinal cord to some extent and also save the injured motor neurons.


CONCLUSIONS
GDNF has a potential clinical value and inestimable future in the treatment of motor neuron diseases.
Cai
Weisong
W
Department of Pediatric Surgery, the Major Laboratory of Health Ministry for Congenital Malformation Research, Second Clinical College (Shengjing Hospital), China Medical University, Shenyang Liaoning, 110004, P. R. China.
Zhao
Hongyu
H
Yuan
Zhengwei
Z
D000818:Animals; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000494:pharmacology* / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D016472:Motor Neuron Disease / Q000188:drug therapy* / Q000503:physiopathology; D009046:Motor Neurons / Q000187:drug effects* / Q000502:physiology; D009410:Nerve Degeneration / Q000188:drug therapy / Q000503:physiopathology
D051100:Glial Cell Line-Derived Neurotrophic Factor