title: Low prevalence of asthma in westernizing countries-myth or reality? Prevalence of asthma in Estonia--a report from the "FinEsS" study.
abstract: OBJECTIVE
  The aim of this study was to examine the prevalence of asthma among adults in Estonia by using different diagnostic methods and criteria for the disease.
  
  
  METHODS
  In 1995-1996, a postal questionnaire was randomly distributed in three areas of Estonia to a representative sample of 22,579 subjects aged 15-64 years. The participation rate was 78%. A clinical follow-up study including structured interview, skin prick test, lung function, and methacholine test, was performed from 1997 to 2000 among randomly selected responders to the postal questionnaire. Of 2676 subjects, 53% participated.
  
  
  RESULTS
  The prevalence of physician-diagnosed asthma for the postal questionnaire (PQ) was 2.7%, and in the same subjects for the structured interview (SI) 3.8%. Respiratory symptoms, except recurrent wheeze, were more common in the SI than PQ. Combinations of symptoms, except wheezing with breathlessness apart from cold, were more prevalent in the PQ responders. The prevalence of asthma defined by different symptom combinations varied from 5.4% to 8.2%. Among responders, 71-87% demonstrated bronchial hyperreactivity defined as methacholine reactivity=8 mg/mL. The symptom combinations used as surrogate variables for asthma were strongly associated with a positive skin test.
  
  
  CONCLUSIONS
  The low prevalence of physician-diagnosed asthma probably reflects a considerable underdiagnosis of asthma in Estonia. Disease criteria for asthma based on symptom combinations together with hyperreactivity yielded a prevalence of 5%-8%, which is similar to the prevalence of asthma among adults in neighboring Western countries.
authors.affiliation: National Institute for Health Development, Tallinn, Estonia. marimeren@hotmail.com
authors.forename: Mari
authors.initials: M
authors.lastname: Meren
authors.forename: Aet
authors.initials: A
authors.lastname: Raukas-Kivioja
authors.forename: Lii
authors.initials: L
authors.lastname: Jannus-Pruljan
authors.forename: Helle-Mai
authors.initials: HM
authors.lastname: Loit
authors.forename: Eva
authors.initials: E
authors.lastname: Rönmark
authors.forename: Bo
authors.initials: B
authors.lastname: Lundbäck
mesh_terms: D000293:Adolescent; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000453:epidemiology; D016085:Bronchoconstrictor Agents; D004957:Estonia / Q000453:epidemiology; D006801:Humans; D007407:Interviews as Topic; D016210:Methacholine Chloride; D008875:Middle Aged; D015995:Prevalence; D012882:Skin Tests; D011795:Surveys and Questionnaires
chemical_list: D018927:Anti-Asthmatic Agents; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride