title: Synthesis, proton and 13C NMR and reaction mechanism studies of novel isoindolones derivatives, obtained through TAWERS procedure.
abstract: A series of novel isoindolone derivatives (13-18) were prepared in goods yields by applying the TAWERS methodology. A general approach for formation of isoindolones from the aza-Wittig reaction of iminophosphoranes with dialdehydes under neutral and mild conditions was realized. Using 1D NMR a [1,3]-hydride migration was detected. The assignment of the structures and conformation behavior of the derivatives was achieved using 1D and 2D NMR (NOESY, DEPT, HMQC, and HMBC).
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior C. Universitaria, Delegación Apartado Postal 70-213, 04510 Coyoacán, México. david.corona@correo.unam.mx
authors.forename: David
authors.initials: D
authors.lastname: Corona
authors.forename: Eduardo
authors.initials: E
authors.lastname: Díaz
authors.forename: Angel
authors.initials: A
authors.lastname: Guzmán
authors.forename: Christophe K
authors.initials: CK
authors.lastname: Jankowski
mesh_terms: D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011522:Protons
chemical_list: D007211:Indoles; D011522:Protons