title: Impaired platelet [3H]paroxetine binding in female patients with borderline personality disorder.
abstract: BACKGROUND
  There have been few studies of platelet paroxetine binding in borderline personality disorder (BPD).
  
  
  OBJECTIVE
  Our aim was to determine whether female BPD subjects show abnormalities in platelet paroxetine binding.
  
  
  METHODS
  Twenty-one female BPD subjects and 16 age- and gender-matched normal control subjects were assessed using the following: (1) Diagnostic Interview for Borderlines, Revised, (2) Diagnostic Assessment for Personality Pathology: Brief Questionnaire, and (3) Barratt Impulsivity Scale. Platelets were collected and assayed for platelet paroxetine binding.
  
  
  RESULTS
  Bmax was lower in the BPD group (p < 0.0001), but differences in Kd only reached a trend level. There were no associations with trait dimensions independent of diagnosis.
  
  
  CONCLUSIONS
  Reduced platelet paroxetine binding in female BPD patients may reflect presynaptic serotonin dysfunction.
authors.affiliation: Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
authors.forename: N M K
authors.initials: NM
authors.lastname: Ng Ying Kin
authors.forename: Joel
authors.initials: J
authors.lastname: Paris
authors.forename: George
authors.initials: G
authors.lastname: Schwartz
authors.forename: Hallie
authors.initials: H
authors.lastname: Zweig-Frank
authors.forename: Howard
authors.initials: H
authors.lastname: Steiger
authors.forename: N P V
authors.initials: NP
authors.lastname: Nair
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D010159:Palate / Q000378:metabolism*; D017374:Paroxetine / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology
chemical_list: D012701:Serotonin; D017374:Paroxetine