EFFECT of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats.
Nicotinic acetylcholine (nAChR) and N-methyl-D-aspartate receptors (NMDARs) play critical roles in memory function. This study administered chronic nicotine to determine the alterations of N-methyl-D-aspartate receptor subunit 2A and 2B (NR2A, NR2B) and the alterations of alpha7nAChR receptor. It was determined that the effectivity of nicotine and the data support that nicotine increases hippocampal NR2A and B expression. Additionally, the role of nicotine in the cognitive improvement was not supported by the antioxidative mechanisms or the authors observed no effect of nicotine on lipid peroxidation at the hippocampus.
Delibas
Namik
N
Department of Biochemistry, Suleyman Demirel University, Medical Faculty, Isparta, Turkey. ndelibas@hotmail.com
Doguc
Duygu Kumbul
DK
Sutcu
Recep
R
Eroglu
Erol
E
Gökalp
Osman
O
D000367:Age Factors; D000375:Aging; D000818:Animals; D015153:Blotting, Western; D003071:Cognition / Q000187:drug effects; D005731:Ganglionic Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism*; D064569:alpha7 Nicotinic Acetylcholine Receptor
D005731:Ganglionic Stimulants; D009538:Nicotine; D016194:Receptors, N-Methyl-D-Aspartate; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; C579165:Chrna7 protein, rat; C121001:NR2B NMDA receptor