Final height after treatment of early puberty in short adopted girls with gonadotrophin releasing hormone agonist with or without growth hormone.
OBJECTIVE
To compare final height data after treatment with gonadotrophin releasing hormone agonist (GnRHa) alone or in combination with growth hormone (GH) in short adopted girls with early puberty.


METHODS
A randomized controlled trial.


METHODS
Twenty-six girls with onset of puberty before 10 years of age were treated for 3 years with either GnRHa alone (group A, n = 12) or with GnRHa and GH (group B, n = 14). Mean age at start of treatment was 9.6 years in both groups, bone age was 10.7 (SD 1.1) years in group A and 11.6 (0.8) years in group B.


RESULTS
Initial height prediction with average Bayley & Pinneau tables was 149.8 (5.6) and 146.8 (4.8) cm, respectively. Bone age at discontinuation of treatment was 12.3 (0.9) and 13.0 (0.6) years in group A and B, respectively. Height gain defined as the difference between initial height prediction and attained final height, was significantly different between group A and B (5.2 (3.7) and 8.2 (3.4) cm, P < 0.05) using average tables for height prediction. With accelerated tables for prediction the numbers were -1.0 (3.6) and 3.3 (3.5) cm, respectively. At final height, there was no significant difference in height: group A: 155.0 (5.6) cm and group B: 155.0 (5.5) cm.


CONCLUSIONS
After 3 years of GnRHa treatment in adopted girls with early puberty, FH is significantly higher than initial height prediction. The addition of GH resulted in a limited further increase in height gain. In the interpretation of the results methodological issues concerning height prediction have to be taken into account.
Mul
D
D
Erasmus MC/Sophia Children's Hospital, Subdivision of Endocrinology, Rotterdam, the Netherlands. d.mul@erasmusmc.nl
Oostdijk
W
W
Waelkens
J J J
JJ
Drop
S L S
SL
D000300:Adoption; D001827:Body Height / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008572:Menarche / Q000502:physiology; D011629:Puberty, Precocious / Q000188:drug therapy*; D016896:Treatment Outcome
D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone