Heparan sulphate proteoglycans: the sweet side of development.
Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.
Häcker
Udo
U
Department of Experimental Medical Science, Lund Center for Stem Cell Biology and Cell Therapy, Lund University, Sweden. udo.hacker@med.lu.se
Nybakken
Kent
K
Perrimon
Norbert
N
D000818:Animals; D005786:Gene Expression Regulation; D006025:Glycosaminoglycans / Q000096:biosynthesis; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D015398:Signal Transduction
D006025:Glycosaminoglycans; D019812:Heparan Sulfate Proteoglycans