title: Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice.
abstract: In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.
authors.affiliation: Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, 10701 East Blvd., Cleveland, OH 44106, USA.
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Pultz
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000254:growth & development; D001427:Bacterial Toxins / Q000378:metabolism*; D002432:Cecum / Q000382:microbiology*; D016360:Clostridioides difficile / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D004768:Enterotoxins / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D004768:Enterotoxins