[Drug tendon disorders].
Tendinitis is a rare adverse reaction described after drugs use. It's described with drug belonging to the same class. Physiopathology is still unknown. Fluoroquinolones especially pefloxacine, were the most incriminated. This drug induced tendinitis in older people aged more than 60 years. Approximatively one case out of five leads to tendon breaking off. The others lead to a favourable outcome after drug withdrawal. In three cases, tendinitis was described with statines, and concerned 2 men and 1 woman, aged more than 50 years. Simvastatine was suspected in two cases and the outcome was favourable in all cases after drug withdrawal. Other drugs, like corticosteroids, can exceptionally induce this side effect that can be serious. Consequences of drug tendinitis can then be dangerous and prescription of this class, and especially fluoroquinolones, must be cautions.
Daghfous
Riadh
R
Centre National de Pharmacovigilance, Sis Hôpital Charles Nicolle, Tunis.
El Aidli
Sihem
S
Gheni
Refaat
R
Belkahia
Chalbi
C
D000305:Adrenal Cortex Hormones; D000368:Aged; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D015994:Incidence; D008875:Middle Aged; D052256:Tendinopathy / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology
D000305:Adrenal Cortex Hormones; D024841:Fluoroquinolones; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors