title: Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma.
abstract: We report a patient with adult T-cell lymphoma who developed acute myeloid leukemia (AML) after allogeneic cord blood transplantation (CBT). Fluorescence in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the AML to be of donor origin. Although 25 cases of donor cell leukemia (DCL) occurring after allogeneic bone marrow transplantation have previously been reported, there have been no reports of DCL after CBT. This case is the first-reported DCL patient after CBT.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan. matunaga@sapmed.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshida
authors.forename: Akihito
authors.initials: A
authors.lastname: Fujimi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Kageaki
authors.initials: K
authors.lastname: Kuribayashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Kogawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Sumio
authors.initials: S
authors.lastname: Sakamaki
authors.forename: Kyuhei
authors.initials: K
authors.lastname: Kohda
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000208:Acute Disease; D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D036101:Cord Blood Stem Cell Transplantation; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000235:genetics; D016399:Lymphoma, T-Cell / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000235:genetics; D020080:Tandem Repeat Sequences; D014019:Tissue Donors; D018183:Transplantation Chimera; D014184:Transplantation, Homologous