Use of consumer product ingredients for patch testing.
BACKGROUND
Patch testing for suspected sensitivity to cosmetics and other personal care products is usually done by testing with nonirritating products "as is" and by panels of antigens likely to contain causative ingredients. Most allergic reactions are reportedly due to sensitivity to either fragrances or preservatives. Although most preservatives found in patients' products are available for patch testing, only a small number of fragrance ingredients are available, and fragrance components are seldom labeled. Most personal care products contain many other ingredients, and unless the patient reacts to the whole product and the ingredients are obtained from the manufacturer, most of these are seldom tested.


OBJECTIVE
To investigate the importance of testing with these other ingredients.


METHODS
Investigators reviewed patch-test records of patients who presented with eruptions compatible with the use of their personal care products and who were tested with available ingredients that were listed on the labels of products they were using. This allowed testing with many ingredients in products that are too irritant for "as is" testing. Some of the results included those of persons who were tested in other series, so these were separated.


RESULTS
Of patch tests with 52 cosmetic ingredients also tested in other series, 3.4% produced at least one+or greater reaction. Of those antigens tested only when present in products used by the patient, 55 of the 121 ingredients produced at least one+reaction, and about 3.6% of the test results were positive.


CONCLUSIONS
Adding ingredients found in the patient's personal care products to patch tests done on those compatible with exposure increases the positive yield in patch testing, and the number of positive results is likely to increase as more ingredients are available for testing.
Guin
Jere D
JD
D000485:Allergens / Q000009:adverse effects; D003358:Cosmetics / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008499:Medical Records; D010328:Patch Tests / Q000592:standards*; D011237:Predictive Value of Tests; D012189:Retrospective Studies
D000485:Allergens; D003358:Cosmetics