title: Secondary diabetes mellitus: late complication of glycogen storage disease type 1b.
abstract: We report a 22 year-old male with glycogen storage disease type 1 (GSD-1) who developed diabetes mellitus secondary to pancreatic islet beta-cell insufficiency. Diabetes mellitus should be considered among the late complications of GSD-1. The pathogenesis of the conversion, from a disease characterized by hypoglycemia to a disease dominated by hyperglycemia, is discussed.
authors.affiliation: Department of Pediatrics A, HaEmek Medical Center, Afula 18101, Israel. spiegelr@zahav.net.il
authors.forename: Ronen
authors.initials: R
authors.lastname: Spiegel
authors.forename: Yardena
authors.initials: Y
authors.lastname: Rakover-Tenenbaum
authors.forename: Hanna
authors.initials: H
authors.lastname: Mandel
authors.forename: Dmitry
authors.initials: D
authors.lastname: Lumelski
authors.forename: Osnat
authors.initials: O
authors.lastname: Admoni
authors.forename: Yoseph
authors.initials: Y
authors.lastname: Horovitz
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000209:etiology* / Q000473:pathology; D005953:Glycogen Storage Disease Type I / Q000150:complications* / Q000473:pathology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007515:Islets of Langerhans / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000000981:diagnostic imaging; D010186:Pancreatic Function Tests; D014057:Tomography, X-Ray Computed