Cyclin D1 overexpression in esophageal cancer from southern China and its clinical significance.
Little reports showed cyclin D1 changes in esophageal cancer from southern China. In this study, we detected cyclin D1 expression in esophageal carcinomas from southern China 61% and 35% cases showed increased expression of cyclin D1 in esophageal carcinomas and the adjacent epithelia, respectively. Significant difference for cyclin D1 expression was found between esophageal carcinomas and the adjacent epithelia. Comparing cyclin D1 expression in the carcinomas at different stages, we found significant alterations. The results suggested that cyclin D1 was involved in the earlier event and accumulated as the cancer evolved to a later stage in some esophageal carcinomas.
Xiao-Ping
Huang
H
State Key Laboratory of Oncology in Southern China, Department of Thoracic Surgery, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China.
Tie-Hua
Rong
R
Peng
Lin
L
Qiu-Liang
Wu
W
Guang-Yu
Yao
Y
Jing-Hui
Hou
H
Xiao-Dong
Su
S
Xiao-Dong
Li
L
Bao-Jiang
Li
L
Peng-Yuan
Zhang
Z
Kai
Long
L
Zhi-Fan
Huang
H
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002681:China; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D020869:Gene Expression Profiling; D006801:Humans; D009367:Neoplasm Staging; D020133:Reverse Transcriptase Polymerase Chain Reaction
D019938:Cyclin D1