Characteristics of benign lymphoadenosis of oral mucosa.
OBJECTIVE
To investigate the pathological characteristics and carcinogenesis mechanism of benign lymphoadenosis of oral mucosa (BLOM).


METHODS
The expressions of Ki-67, CD34 and apoptosis were evaluated by immunohistochemical SP staining in 64 paraffin-embedded tissue samples. Of them, 9 were from BLOM with dysplasia, 15 from BLOM without dysplasia, 15 from oral squamous cell carcinoma (OSCC), 15 from oral precancerosis, and 10 from normal tissues. Cell proliferation, apoptosis and angiogenesis of tissue samples were also analyzed.


RESULTS
The expression of Ki-67 in BLOM with dysplasia, oral precancerosis and OSCC was significantly higher than in BLOM without dysplasia and normal mucosa. The microvascular density (MVD) in BLOM with and without dysplasia, oral precancerosis, and OSCC was significantly higher than in normal mucosa. Apoptosis in BLOM and oral precancerosis was significantly higher than in OSCC and normal mucosa.


CONCLUSIONS
Benign lymphoadenosis of oral mucosa has potentialities of cancerization.
Li
Shu-Xia
SX
Department of Oral Pathology, School of Stomatology, Peking University, Beijing 100081, China. lishuxia@sina.com
Yu
Shi-Feng
SF
Sun
Kai-Hua
KH
D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D006801:Humans; D020287:In Situ Nick-End Labeling; D008221:Lymphoid Tissue / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*