Cellular iron: ferroportin is the only way out.
Ferroportin is the sole cellular efflux channel for iron and is regulated by the iron regulatory hormone hepcidin, which binds ferroportin and induces its internalization and degradation. New studies of ferroportin knockout mice define a key role for this transporter in physiological iron balance.
Ganz
Tomas
T
Department of Medicine, David Gefen School of Medicine, Unvirsity of California, Los Angeles, California 90095, USA.
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism / Q000502:physiology; D027682:Cation Transport Proteins / Q000378:metabolism*; D064451:Hepcidins; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D000098742:Ferroportin
D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; C578702:HAMP protein, human; C579599:Hamp protein, mouse; D064451:Hepcidins; D000098742:Ferroportin; D007501:Iron