title: Chromosome 1p loss: a favorable prognostic factor in low-grade gliomas.
abstract: Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor (EGFR) gene amplification, and p53 expression was performed in a series of 131 low-grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression-free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression-free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low-grade gliomas.
authors.affiliation: INSERM U711 et Université Pierre et Marie Curie Paris VI, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Kujas
authors.forename: Julie
authors.initials: J
authors.lastname: Lejeune
authors.forename: Alexandra
authors.initials: A
authors.lastname: Benouaich-Amiel
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Crinière
authors.forename: Florence
authors.initials: F
authors.lastname: Laigle-Donadey
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marie
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
authors.forename: Marc
authors.initials: M
authors.lastname: Polivka
authors.forename: Michèle
authors.initials: M
authors.lastname: Bernier
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chretien
authors.forename: Anne
authors.initials: A
authors.lastname: Couvelard
authors.forename: Laurent
authors.initials: L
authors.lastname: Capelle
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Philippe
authors.initials: P
authors.lastname: Cornu
authors.forename: Philippe
authors.initials: P
authors.lastname: Broët
authors.forename: Joëlle
authors.initials: J
authors.lastname: Thillet
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Carpentier
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
authors.forename: Khê
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D008967:Molecular Biology / Q000379:methods