title: Regenerative medicine of the trachea: the first human case.
abstract: OBJECTIVE
  The objective of the present study was to demonstrate regenerative medicine of the tracheal tissue by using an in situ tissue engineering technique for airway reconstruction.
  
  
  METHODS
  Based on the previous successful experimental animal studies, the current regenerative technique was applied to repair of the trachea of a 78-year-old woman with thyroid cancer. A Marlex mesh tube covered by collagen sponge was used as a tissue scaffold. The operative intervention included right hemithyroidectomy, resection of the trachea, and tracheoplasty using the scaffold. The right half of three rings of the trachea was resected, and the scaffold material was sutured to the defect of the trachea.
  
  
  RESULTS
  After 2 weeks, the mesh collagen structure of the artificial material could be seen with endoscopy in most of the implanted area. The artificial material was covered with epithelial growth after 2 months. Epithelialization continued to cover the artificial material completely for 2 years without any complications.
  
  
  CONCLUSIONS
  The current regenerative technique avoided tracheotomy, a second operation, and deformity. Good epithelialization has been observed on the tracheal luminal surface without any complications for 2 years. Although long-term observation is required, regenerative medicine of the tracheal tissue appears feasible for airway reconstruction.
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, School of Medicine, Fukushima City, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Omori
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kanemaru
authors.forename: Ryo
authors.initials: R
authors.lastname: Asato
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamashita
authors.forename: Shinzo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Akhmar
authors.initials: A
authors.lastname: Magrufov
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D001705:Bioprosthesis; D003094:Collagen; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D007820:Laryngeal Mucosa / Q000254:growth & development; D011126:Polypropylenes; D013526:Surgical Mesh; D013964:Thyroid Neoplasms / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*; D014132:Trachea / Q000502:physiology / Q000601:surgery*
chemical_list: D011126:Polypropylenes; D003094:Collagen