Nitric oxide in wound-healing.
Modulation of the complex process of wound-healing remains a surgical challenge. Little improvement beyond controlling infection, gentle tissue handling, and debridement of necrotic tissue has been had in the modern era. However, increasing appreciation of the process from a biomolecular perspective offers the potential for making significant strides in wound modulation. The bioactive molecule nitric oxide was found to have wide-ranging impact on cellular activities, including the cellular responses engendered by wound healing. Current research suggests that nitric oxide and several nitric oxide donors can exert biologic effects, although the particular net responses of cells contributing to wound repair are context-dependent.
Isenberg
Jeff S
JS
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1500, USA. isenberj@mail.nih.gov
Ridnour
Lisa A
LA
Espey
Michael Graham
MG
Wink
David A
DA
Roberts
David D
DD
D006801:Humans; D009569:Nitric Oxide / Q000737:chemistry / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy
D009569:Nitric Oxide