title: [Influence of Xinqin tablets on guinea-pig nasal hypersensitivity].
abstract: OBJECTIVE
  To study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity.
  
  
  METHODS
  2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase (NOS) were examined.
  
  
  RESULTS
  Xinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase.
  
  
  CONCLUSIONS
  Xinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.
authors.affiliation: West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Jun-rong
authors.initials: JR
authors.lastname: Du
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Wei
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Long
mesh_terms: D000818:Animals; D030023:Asarum / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D031363:Scutellaria / Q000737:chemistry; D014051:Toluene 2,4-Diisocyanate
chemical_list: D004365:Drugs, Chinese Herbal; C000617119:xinqin; D014051:Toluene 2,4-Diisocyanate; D006632:Histamine; D019001:Nitric Oxide Synthase