[Effect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages].
It is stated that Livagen (Lys-Glu-Asp-Ala) is a weakly hydrolyzed peptide. Peptide hydrolases of small intestine do not hydrolyze Livagen even to a small extent. Under in vitro conditions Livagen reduces glycil-L-leucinedipeptidase activity in small intestine by 50%. After two weeks of Livagen administration per os in rats the digestive enzymes activity in young animals reduces, while in old animals it increases. It should be mentioned that the activity of enzymes in old rats after Livagen administration in the majority of cases approaches to the level of the activity in young animals of control group.
Timofeeva
N M
NM
Khavinson
V Kh
VKh
Malinin
V V
VV
Nikitina
A A
AA
Egorova
V V
VV
D000367:Age Factors; D000818:Animals; D004150:Dipeptidases / Q000378:metabolism*; D006868:Hydrolysis; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
C473185:Livagen; D009842:Oligopeptides; D010455:Peptides; D004150:Dipeptidases; C020825:cytosol non-specific dipeptidase