Kisspeptins and GPR54--the new biology of the mammalian GnRH axis.
Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.
Aparicio
Samuel A J R
SA
University of Cambridge Department of Oncology, Hutchison-MRC Research Centre, Cambridge CB2 2XZ, United Kingdom. saparicio@bccrc.ca
D000818:Animals; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D059648:Kisspeptins; D051379:Mice; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1; D018013:Receptors, Neuropeptide / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D025521:Tumor Suppressor Proteins
D012739:Gonadal Steroid Hormones; C106628:KISS1 protein, human; C118688:KISS1R protein, human; C491407:Kiss1 protein, mouse; C492248:Kiss1r protein, mouse; D059648:Kisspeptins; D011506:Proteins; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1; D018013:Receptors, Neuropeptide; D025521:Tumor Suppressor Proteins; D007987:Gonadotropin-Releasing Hormone