[Gene testing of hereditary cancer on comprehensive gene medical examination support system].
It has been estimated that genetic factors or a combination of genetic and environmental factors play a role in the development of 10-15% of all cancers. A genetic cause of hereditary cancer has been identified in more than 40 diseases till now. For preventing this cancer, gene testing is essential because it has no definite clinical marker as in hereditary non-polyposis colorectal cancer: HNPCC. Much more experience must be accumulated in this testing at the clinical base in order to increase specificity and sensitivity while safeguarding ethical, legal and social issues (ELSI). Recently, the Personal Information Protection Law was enforced. Gene inspection involving hereditary cancer should be carried out under a comprehensive gene medical examination organization. It is important for the family doctor, medical specialist, and gene inspection person in charge to cooperate closely with one another, and this will be a subject of future study.
Shirahama
Shuya
S
Center for Molecular Biology and Cytogenetics Gene Analysis Section, SRL Inc., Tokyo, Japan.
Ito
Taichi
T
Hosoya
Mina
M
Kosaki
Tomoko
T
Ijuin
Junko
J
Kakimoto
Atsushi
A
Ishihara
Yoshimori
Y
Tamura
Kazuo
K
Sugai
Sachiko
S
Arai
Masami
M
Miki
Yoshio
Y
Muto
Tetsuichiro
T
Utsunomiya
Joji
J
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics; D030541:Databases, Genetic; D005816:Genetic Complementation Test; D005817:Genetic Counseling; D005820:Genetic Testing; D006801:Humans; D007258:Informed Consent; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D016133:Polymerase Chain Reaction