title: Development of a polyvinyl alcohol hydrogel for temperature measurement by MRI.
abstract: This paper describes the development of a Polyvinyl alcohol hydrogel (PVA-H) model for calibration and measurement of temperature using image contrast on MRI using DMSO/H_2O as a solvent to alter the freezing and melting points of PVA-H. Tissues exposed to temperature changes above 41 degrees C or below 0 degrees C exhibit increasingly extensive and irreversible damage, depending on the exposure duration. MR images can provide a map of temperature if there is sufficient tissue signal. To evaluate treatment principles using temperature changes (hyperthermia, cryotherapy), a model simulating tissue may be useful to provide a reproducible test environment. PVA-H is water soluble and can be seen on MRI. It can be used to construct complicated shapes such as vascular structure, soft tissues, and so on. Therefore, PVA-H can be useful to measure temperatures and assume the distribution of temperature under treatment. In this paper, we applied PVA-H as a temperature detector and calibrated temperature from image contrast. The results exhibit good capability as a temperature detector not only of high temperature (around 41 degrees C), but also of low temperature (as low as -23 degrees C).
authors.affiliation: Section of Neuroradiology, Department of Radiology, Geneva University Hospital, Geneva, Switzerland. ota@fmail.ifs.tohoku.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohta
authors.forename: J Paul
authors.initials: JP
authors.lastname: Jacobson
authors.forename: Emile
authors.initials: E
authors.lastname: Hiltbrand
authors.forename: Alexis
authors.initials: A
authors.lastname: Kelekis
authors.forename: Marko
authors.initials: M
authors.lastname: Ivancevic
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Rüfenacht
authors.forename: Hiroo
authors.initials: H
authors.lastname: Iwata
authors.forename: Sadami
authors.initials: S
authors.lastname: Tsutsumi
mesh_terms: D002138:Calibration; D017679:Cryotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D011142:Polyvinyl Alcohol; D013557:Switzerland; D013696:Temperature; D014481:United States
chemical_list: C062364:polyvinyl alcohol hydrogel; D011142:Polyvinyl Alcohol