title: Cognitive therapy does not prevent a response to tryptophan depletion in patients also treated with antidepressants.
abstract: BACKGROUND
  Acute tryptophan depletion (ATD) induces depressive symptoms in remitted depressed patients treated with serotonergic medications, but not in patients treated with noradrenergic medications or electroconvulsive therapy. A recent study suggests that cognitive therapy (CT) protects against the effects of ATD, but the evidence is questionable. The present study compared the effect of ATD in patients who were treated with antidepressant medication and CT (n = 17) versus antidepressant medication alone (n = 23) during their latest episode.
  
  
  METHODS
  Forty remitted depressed patients underwent high-dose and low-dose ATD in a randomized double-blind crossover design.
  
  
  RESULTS
  There were no differences in response to ATD between treatment groups. This applied to groups defined by lifetime and by recent CT experience.
  
  
  CONCLUSIONS
  Cognitive therapy does not protect against the effects of rapidly lowered plasma tryptophan levels in remitted depressed patients who are also treated with antidepressant medication.
authors.affiliation: Department of Psychology, Leiden University, The Netherlands. vanderdoes@fsw.leiden.univ.nl
authors.forename: A J Willem
authors.initials: AJ
authors.lastname: Van der Does
authors.forename: Linda
authors.initials: L
authors.lastname: Booij
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001519:Behavior; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D014364:Tryptophan / Q000172:deficiency*
chemical_list: D000928:Antidepressive Agents; D014364:Tryptophan