title: Positively selected sites in the Arabidopsis receptor-like kinase gene family.
abstract: We analyze members of the receptor-like kinase (RLK) gene family in Arabidopsis thaliana for positive selection. Likelihood analyses find evidence for positive selection in 12 of the 52 RLK family sequences groups. These 12 groups represent 97 of the 403 sequences analyzed. The majority of genes in groups subject to positive selection have not been functionally characterized, but sites under selection are predominantly located in the extracellular region. The pattern of selection in the extracellular leucine-rich repeat (LRR) motif of groups 14 and 51 is similar to previous studies where positively selected positions are located in a solvent exposed beta-strand that may determine disease specificity, raising the possibility that some RLK genes function in a similar role.
authors.affiliation: Bioinformatics Research Center, Campus Box 7566, North Carolina State University, Raleigh, NC, 27695-7566, USA, muse@stat.ncsu.edu.
authors.forename: Errol
authors.initials: E
authors.lastname: Strain
authors.forename: Spencer V
authors.initials: SV
authors.lastname: Muse
mesh_terms: D017360:Arabidopsis / Q000145:classification* / Q000201:enzymology / Q000235:genetics*; D029681:Arabidopsis Proteins / Q000145:classification* / Q000235:genetics*; D007930:Leucine / Q000235:genetics; D010770:Phosphotransferases / Q000145:classification* / Q000235:genetics*; D010802:Phylogeny
chemical_list: D029681:Arabidopsis Proteins; D010770:Phosphotransferases; D007930:Leucine