title: Successful treatment of a patient with synchronous advanced non-small cell lung cancer and acute myeloid leukemia by a combination of gefitinib, low-dose cytarabine and aclarubicin.
abstract: There are few reports describing simultaneous occurrence of acute leukemia and lung cancer. We describe here an 83-year-old woman who simultaneously developed advanced adenocarcinoma of the lung and acute myeloid leukemia. She could not receive intensive chemotherapy due to poor performance status. This patient was treated with a combination of gefitinib, low-dose cytarabine and aclarubicin. This combination could be safely administered in the elderly patient with poor performance status and was effective for both lung cancer and acute myeloid leukemia.
authors.affiliation: Department of Pulmonary Medicine, National Hospital Organization, Minarmi-Okayama Medical Center, 4066 Hayashima, Okayama 701-0304, Japan. takigawan@s-okayama.hosp.go.jp
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Takuo
authors.initials: T
authors.lastname: Shibayama
authors.forename: Isao
authors.initials: I
authors.lastname: Yoshida
authors.forename: Noriko
authors.initials: N
authors.lastname: Kawata
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Tada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueoka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage; D000208:Acute Disease; D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D016330:Frail Elderly; D000077156:Gefitinib; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy*; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D011799:Quinazolines / Q000008:administration & dosage
chemical_list: D011799:Quinazolines; D003561:Cytarabine; D015250:Aclarubicin; D000077156:Gefitinib