[Research status of genodermatoses in China].
Among over 300 genodernatoses, causative genes have been identified in 170 monogenetic diseases, while gene mapping has been performed in over 100 monogenetic and polygenctic skin diseases. Researches in genodermatoses has rapidly advanced in China in recent ten years. The causative genes involved in multiple familial trichoepithelioma and primary erythermalgia have been found. Two independent genome-wide scans with DNA markers have been performed to detect genetic linkage related to psoriasis and vitiligo. In this review article, we summarize these most recent findings.
Zhang
Xue-Jun
XJ
Key Laboratory of Genome Research at Anhui, Institute of Dermatology, Anhui Medical University, Hefei 230032, China. ayzxj@vip.sina.com.cn
Chen
Jian-jun
JJ
Gao
Min
M
D004916:Erythromelalgia / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D062556:NAV1.7 Voltage-Gated Sodium Channel; D011506:Proteins / Q000235:genetics; D011565:Psoriasis / Q000235:genetics*; D015222:Sodium Channels / Q000235:genetics; D014820:Vitiligo / Q000235:genetics*
D006680:HLA Antigens; D062556:NAV1.7 Voltage-Gated Sodium Channel; C484393:PSORS1C1 protein, human; D011506:Proteins; C486866:SCN9A protein, human; D015222:Sodium Channels