Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.
Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, beta-sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99% at a concentration of 100 microg/mL.
Jiménez
Adelina
A
Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatria, Centro Medico Siglo XXI, IMSS, Mexico. adelinaj@servidor.unam.mx
Meckes
Mariana
M
Alvarez
Victor
V
Torres
Javier
J
Parra
Ruth
R
D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018432:Drug Resistance, Multiple; D006801:Humans; D019684:Magnoliopsida; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000995:Antitubercular Agents; D010936:Plant Extracts