Effect of aqueous extract from Nigella sativa L. on guinea pig isolated heart.
A potent inhibitory effect of aqueous extract from N. sativa on calcium channel of guinea pig heart was found comparable and even greater than that of diltazem. The results may also indicate an opening effect for the plant on potassium channel of isolated heart.
Shafei
Mohammad Naser
MN
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, 91735, Iran.
Boskabady
Mohammad Hossein
MH
Parsaee
Heydar
H
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D031881:Nigella sativa; D010936:Plant Extracts / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D014867:Water
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D010936:Plant Extracts; D015221:Potassium Channels; D014867:Water; D004110:Diltiazem