title: Lack of antagonism between abacavir, lamivudine, and tenofovir against wild-type and drug-resistant HIV-1.
abstract: Potential contributors to the high rate of virologic failure observed for tenofovir, abacavir, and lamivudine include a low genetic barrier to resistance for this regimen and antagonistic drug-drug interactions. To examine the second possibility, we tested combinations of abacavir, tenofovir, and lamivudine against wild-type and drug-resistant HIV-1 in vitro using peripheral blood mononuclear cells and MT-4 cells. Antagonistic interactions were not detected for any combination. If the systems examined accurately reflect the in vivo situation, antagonism does not substantially contribute to the poor efficacy of this triple combination.
authors.affiliation: GlaxoSmithKline, Research Triangle Park, NC 27705, USA. ernest.r.lanier@gsk.com
authors.forename: E Randall
authors.initials: ER
authors.lastname: Lanier
authors.forename: Richard
authors.initials: R
authors.lastname: Hazen
authors.forename: Lisa
authors.initials: L
authors.lastname: Ross
authors.forename: Andy
authors.initials: A
authors.lastname: Freeman
authors.forename: Robert
authors.initials: R
authors.lastname: Harvey
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002461:Cell Line, Transformed; D015224:Dideoxynucleosides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics; D004359:Drug Therapy, Combination; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D019259:Lamivudine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009154:Mutation; D063065:Organophosphonates / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000068698:Tenofovir; D000099227:Abacavir
chemical_list: D000225:Adenine; D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D019259:Lamivudine; D063065:Organophosphonates; D000068698:Tenofovir; D000099227:Abacavir