title: [Electroencephalography measures in motor skill learning and effects of bromazepam].
abstract: Neuromodulators change brain's neural circuitry. Bromazepam is often been used in the pharmacological treatment of anxiety disorders. Few papers links this anxiolytic to motor tasks. The purpose of this study was to examine motor and electrophysiological changes produced by administration of bromazepam in differents doses (3 and 6 mg). The sample consisted of 39 healthy individuals, of both sexes, between 20 and 30 years of age. The control (placebo) and experimental (bromazepam 3mg and bromazepam 6 mg) groups were submitted to a typewriting task, in a randomized, double-blind design. The results did not reveal differences on score and time of the attention test. In the comportamental analysis was noticed blocks as main effect to behavioral variables (time and mistakes in the task). Electrophysiological data showed significants interactions to: laterally/condition/moment; laterally/condition; laterally/moment; condition/moment; condition/site.
authors.affiliation: Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Brazil. victorhvbastos@uol.com.br
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Bastos
authors.forename: Dionis
authors.initials: D
authors.lastname: Machado
authors.forename: Marlo
authors.initials: M
authors.lastname: Cunha
authors.forename: Claudio Elidio
authors.initials: CE
authors.lastname: Portella
authors.forename: Maurício
authors.initials: M
authors.lastname: Cagy
authors.forename: Vernon
authors.initials: V
authors.lastname: Furtado
authors.forename: Roberto
authors.initials: R
authors.lastname: Piedade
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001960:Bromazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006225:Hand / Q000502:physiology; D006801:Humans; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009048:Motor Skills / Q000187:drug effects* / Q000502:physiology
chemical_list: D014151:Anti-Anxiety Agents; D001960:Bromazepam