title: Bilateral hemodynamic responses to auditory stimulation in newborn infants.
abstract: We studied hemodynamic auditory evoked responses of 20 healthy full-term neonates with near-infrared spectroscopy. The instrument used allows the measurements to be performed simultaneously above both auditory cortices. The stimulation consisted of 5-s trains of sound (700-ms interstimulus interval) with a 25-s silent interval. In response to the stimulation, a significant increase in concentration of oxygenated hemoglobin was detected in 14 out of 21 measurements. The mean latency of the largest response was 9.63+/-2.20 s (mean+/-SD) and the mean amplitude was 1.02+/-0.53 microM. The response amplitude was significantly larger in active (1.28+/-0.59 microM) than in quiet sleep (0.76+/-0.32 microM). The latency of the oxygenated hemoglobin concentration response was significantly shorter (r=-0.70 and p=0.0023) for infants with higher gestational age.
authors.affiliation: Laboratory of Biomedical Engineering, Helsinki University of Technology, University of Helsinki, Helsinki, Finland. kalle.kotilahti@hut.fi
authors.forename: Kalle
authors.initials: K
authors.lastname: Kotilahti
authors.forename: Ilkka
authors.initials: I
authors.lastname: Nissilä
authors.forename: Minna
authors.initials: M
authors.lastname: Huotilainen
authors.forename: Riikka
authors.initials: R
authors.lastname: Mäkelä
authors.forename: Nasia
authors.initials: N
authors.lastname: Gavrielides
authors.forename: Tommi
authors.initials: T
authors.lastname: Noponen
authors.forename: Patrick
authors.initials: P
authors.lastname: Björkman
authors.forename: Vineta
authors.initials: V
authors.lastname: Fellman
authors.forename: Toivo
authors.initials: T
authors.lastname: Katila
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D001303:Auditory Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D005865:Gestational Age; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D012890:Sleep / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013223:Statistics as Topic
chemical_list: D006454:Hemoglobins