Mechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia.
A thorough understanding of the renal and cardiovascular adaptations to normal gestation is essential for proper diagnosis and management of hypertensive disorders and renal diseases during pregnancy. Here, we briefly review the renal hemodynamic changes of normal pregnancy. In addition, we present new findings and current concepts related to the underlying hormonal and molecular mechanisms. Finally, we speculate on the potential contribution of these insights from normal pregnancy to the pathogenesis of preeclampsia.
Conrad
K P
KP
Department of Obstetrics/Gynecology, University of Pittsburgh School of Medicine and Magee-Women's Research Institute, Pittsburgh, PA 15213, USA. rsikpc@mwri.magee.edu
Novak
J
J
Danielson
L A
LA
Kerchner
L J
LJ
Jeyabalan
A
A
D000818:Animals; D004108:Dilatation, Pathologic; D005260:Female; D005919:Glomerular Filtration Rate; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy / Q000502:physiology*; D014664:Vasodilation
D006728:Hormones