1166C mutation of angiotensin II type 1 receptor gene is correlated with umbilical blood flow velocimetry in women with preeclampsia.
OBJECTIVE
To ascertain the frequency of polymorphic variants of the gene coding for angiotensin II type 1 receptor (AT1) and its correlation with umbilical artery (UA) blood flow velocity in a group of women with preeclampsia (PE).


METHODS
AT1 polymorphism, pulsatility index (PI) in UA, and perinatal outcome in 47 women with PE and in 113 healthy pregnant women were investigated. Investigation of AT1 receptor genotypes was performed by PCR/RFLP assays. PI value has been measured by Doppler velocimetry technique.


RESULTS
The overrepresentation of CC homozygotic genotype in PE group (6.4% vs. 2.7%) and the overrepresentation of mutated C allele in the PE group were observed (28.7% vs. 23.0%). Analyzing PI index we observed statistically significant differences between PE and control groups. Comparing PI values in PE group between genotypes: AA vs. AC + CC statistically significant differences (p < 0.05) have been observed.


CONCLUSIONS
Observed overrepresentation of mutated C allele of the AT1 gene was correlated with increased blood flow in umbilical artery in women with preeclampsia. Doppler velocimetry might be a useful tool for indication in the high-risk group with overrepresentation of C alleles.
Seremak-Mrozikiewicz
Agnieszka
A
Department of Perinatology and Gynecology, University School of Medical Sciences, Poznań, Poland. asm@data.pl
Dubiel
Mariusz
M
Drews
Krzysztof
K
Breborowicz
Grzegorz H
GH
Mrozikiewicz
Przemysław M
PM
D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics* / Q000503:physiopathology*; D011247:Pregnancy; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D014470:Umbilical Cord / Q000098:blood supply* / Q000502:physiology
D044140:Receptor, Angiotensin, Type 1