title: Immunohistochemical detection of the expression of the cell adhesion molecules E-cadherin, desmoglein-2, beta4-integrin, ICAM-1 and HCAM (CD44s) in Warthin's tumour of the parotid gland.
abstract: The study of the expression of cell adhesion molecules (CAMs), E-cadherin, desmoglein-2, beta4-integrin, HCAM (CD44s) and ICAM-1 in Warthin's tumours. Twenty formalin--fixed, paraffin--embedded parotid Warthin's tumours were studied using an Envision/HRP immunohistochemical technique. Beta4-integrin was strongly expressed in all cell-basement membrane and intercellular contacts of the epithelium, E-cadherin and desmoglein-2 in cell-cell contacts, but not in basal cell-basement membrane connections and on columnar cells' luminal surfaces, HCAM (CD44s) in intercellular contacts of both luminal (mainly), basal cells and also in the periphery of monocytic-lymphocytic stroma, and ICAM-1 was weak to moderate expressed in both luminal and basal epithelial cells and strongly in the germinal lymphocytic centres. CAM expression suggests a bilayered excretory ductal structure of the neoplastic epithelium in Warthin's tumour, as a result of hyperplastic process of the glandular epithelium that interacts with the excessive lymphoid tissue of the stroma.
authors.affiliation: Department of Oral Medicine and Maxillofacial Pathology, Dental School, Aristotle University of Thessaloniki, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Andreadis
authors.forename: Apostolos
authors.initials: A
authors.lastname: Epivatianos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Poulopoulos
authors.forename: Alexandros
authors.initials: A
authors.lastname: Nomikos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Christidis
authors.forename: Georgios
authors.initials: G
authors.lastname: Papazoglou
authors.forename: Demetrios
authors.initials: D
authors.lastname: Antoniades
authors.forename: Calypso
authors.initials: C
authors.lastname: Barbatis
mesh_terms: D000235:Adenolymphoma / Q000378:metabolism* / Q000473:pathology; D015820:Cadherins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D051301:Desmoglein 2 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D039663:Integrin beta4 / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D015820:Cadherins; D015815:Cell Adhesion Molecules; D051301:Desmoglein 2; D039663:Integrin beta4; D009363:Neoplasm Proteins