Infectivity of Cryptosporidium hominis and Cryptosporidium parvum genotype 2 isolates in immunosuppressed Mongolian gerbils.
One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 x 10(5) oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained for 21 to 22 days. The data suggest that immunosuppressed gerbils provide a reliable rodent model of persistent C. hominis infection.
Baishanbo
Asiya
A
Laboratoire d'Immunologie et d'Immunopathologie, CHU Clemenceau, 14033 Caen Cedex, France.
Gargala
Gilles
G
Delaunay
Agnès
A
François
Arnaud
A
Ballet
Jean-Jacques
JJ
Favennec
Loïc
L
D000818:Animals; D003457:Cryptosporidiosis / Q000276:immunology*; D016785:Cryptosporidium parvum / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D005838:Genotype; D005849:Gerbillinae; D007165:Immunosuppression Therapy