Cyclophilin B escorts the hepatitis C virus RNA polymerase: a viral achilles heel?
A recent report by Watashi et al. (2005) in Molecular Cell reveals a role for the host cell prolyl isomerase cyclophilin B (CyPB) in the replication of the hepatitis C viral genome, opening potential avenues for antiviral therapeutic intervention.
Heitman
Joseph
J
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Cullen
Bryan R
BR
D021983:Cyclophilins / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008024:Ligands; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D014779:Virus Replication
D008024:Ligands; C081786:cyclophilin B; D012321:DNA-Directed RNA Polymerases; D021983:Cyclophilins; D019696:Peptidylprolyl Isomerase