Thermal behaviour and stability in Olanzapine.
The stability and thermal behaviour of two anhydrate phases and a new mixed water:DMSO solvate of Olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine) are studied by different methods: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and Raman scattering (RS). Single crystal structural data for the latter phase are presented, confirming the presence of the (Olanzapine)(2) dimer as the structural building unit of all known phases of the drug, either anhydrate or solvated. An apparent interconversion between both solid state forms is shown to be an artifact and explained in terms of a melting-recrystallization process.
Polla
Griselda I
GI
Unidad de Actividad Física, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, San Martín, 1650 Buenos Aires, Argentina.
Vega
Daniel R
DR
Lanza
Hilda
H
Tombari
Dora G
DG
Baggio
Ricardo
R
Ayala
Alejandro Pedro
AP
Filho
Josué Mendes
JM
Fernández
Daniel
D
Leyva
Gabriela
G
Dartayet
Gustavo
G
D014150:Antipsychotic Agents / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D004121:Dimethyl Sulfoxide; D004355:Drug Stability; D006358:Hot Temperature; D008958:Models, Molecular; D000077152:Olanzapine; D012997:Solvents; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry; D014961:X-Ray Diffraction
D014150:Antipsychotic Agents; D012997:Solvents; D001569:Benzodiazepines; D000077152:Olanzapine; D004121:Dimethyl Sulfoxide