In vitro efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus.
We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V. vulnificus in vitro, and this combination regimen can be a good choice as the empirical treatment for suspected necrotizing fasciitis due to V. vulnificus.
Kim
Dong-Min
DM
Department of Laboratory Medicine, Chosun University Medical School, 588 Seoseok-dong, Dong-gu, Gwang-Ju 501-717, South Korea.
Lym
Yong
Y
Jang
Sook Jin
SJ
Han
Hulin
H
Kim
Young Gi
YG
Chung
Choon-Hae
CH
Hong
Soon Pyo
SP
D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000592:standards; D002439:Cefotaxime / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008911:Minocycline / Q000494:pharmacology; D041261:Vibrio vulnificus / Q000187:drug effects* / Q000254:growth & development
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D008911:Minocycline; D002439:Cefotaxime