A note on the antitubercular activities of 1-aryl-5-benzylsulfanyltetrazoles.
A set of 32 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was synthesized. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis. The activity against M. tuberculosis becomes higher with increasing electron-accepting properties of the substituents on the phenyl ring. On the other hand, any substitution on the benzylic moiety decreases the activity.
Adamec
Jan
J
Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, Hradec Králové, Czech Republic.
Waisser
Karel
K
Kunes
Jirí
J
Kaustová
Jarmila
J
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000995:Antitubercular Agents; D013777:Tetrazoles