Radical cross-linked albumin microspheres as potential drug delivery systems: preparation and in vitro studies.
The aim of this research is the preparation of acryloylated bovine serum albumin microspheres and the evaluation of their employment in drug delivery. The influence of preparation parameters on albumin microspheres and the chemicophysical properties of loaded drugs were investigated. In particular, we focused our attention on acylation albumin degree, amount of acryloylated albumin against comonomer in the polymerization step, and finally the release profile. We considered on the interaction drug-matrix, the fuctionalization degree of albumin, and the water affinity of matrix.
Iemma
F
F
Dipartimento di Scienze Farmaceutiche, Università della Calabria, Rende, Italy. francesca.iemma@unical.it
Spizzirri
U G
UG
Puoci
F
F
Muzzalupo
R
R
Trombino
S
S
Picci
N
N
D000179:Acrylates / Q000737:chemistry; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000645:Ammonium Sulfate / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D001378:Azasteroids / Q000737:chemistry; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry; D004061:Diflunisal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D013196:Dihydrotestosterone / Q000031:analogs & derivatives / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005472:Fluorouracil / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009942:Organometallic Compounds / Q000737:chemistry; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D011433:Propranolol / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D012709:Serum Albumin / Q000737:chemistry*
D000179:Acrylates; D000319:Adrenergic beta-Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001378:Azasteroids; D003432:Cross-Linking Reagents; D009942:Organometallic Compounds; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; C450681:phenyllithium; D013196:Dihydrotestosterone; C031276:ammonium peroxydisulfate; C031563:17-N,N-diethylcarbamoyl-4-methyl-4-azaandrostane-3-one; D004061:Diflunisal; D011433:Propranolol; C036658:acrylic acid; D000645:Ammonium Sulfate; D005472:Fluorouracil