Bone mineral density in premenopausal women with major depression.
OBJECTIVE
To investigate the relationship between the major depression and bone mineral density (BMD) in premenopausal women.


METHODS
We compared BMD, plasma cortisol level, osteocalcin and C-telopeptide levels of 35 premenopausal women with major depression with those of 30 healthy women who were matched for age and body mass index. Major depression was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders (fourth edition) criteria. Nineteen patients had mild and 16 patients had moderate severity of major depression as measured by Hamilton rating scale for depression.


RESULTS
Women with any risk factor for osteoporosis were excluded from the study. All women underwent BMD measurement by DEXA at lumbar (L2-4) and femoral neck region. After an overnight fasting, plasma cortisol levels were measured at 08:00 h by using competitive immunoassay method. Osteocalcin and C-telopeptide were used for the evaluation of bone turnover. There were no significant differences in BMD, plasma cortisol level, osteocalcin and C-telopeptide levels between the patients and the control groups. There was also no correlation between the plasma cortisol level, the duration and the severity of disease, antidepressant drug use and BMD.


CONCLUSIONS
Major depression had no significant effect on BMD and bone turnover markers in our patient group of mild to moderate severity of the disorder.
Yazici
Aylin Ertekin
AE
Department of Psychiatry, Mersin University Medical School, Mersin, Turkey.
Bagis
Selda
S
Tot
Senel
S
Sahin
Gunsah
G
Yazici
Kemal
K
Erdogan
Canan
C
D000328:Adult; D015519:Bone Density; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D003865:Major Depressive Disorder / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood
D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen; D006854:Hydrocortisone