title: Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides.
abstract: Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.
authors.affiliation: Veterans Affairs Puget Sound Health Care System, S-111-ID, 1660 S. Columbian Way, Seattle, WA 98108, USA. bmenzies@u.washington.edu
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Menzies
authors.forename: Aimee
authors.initials: A
authors.lastname: Kenoyer
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis / Q000235:genetics*; D004817:Epidermis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000378:metabolism; D013203:Staphylococcal Infections / Q000378:metabolism*; D013211:Staphylococcus aureus; D013682:Teichoic Acids / Q000378:metabolism
chemical_list: D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid