Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder.
This prospective study aimed to determine whether patients with endometriosis are having different level of interlukin-17 (IL-17) in peritoneal fluid when compared with patients without endometriosis. The patients with minimal/mild endometriosis had a significantly higher level of IL-17 in peritoneal fluid compared with those with moderate/severe endometriosis or without endometriosis. The concentration of IL-17 in peritoneal fluid was significantly higher when endometriosis and infertility coexist. However, the concentration of IL-17 in peritoneal fluid did not correlate with the phase of the menstrual cycle in the patients with or without endometriosis. Our study suggested that IL-17 might play an important role in the pathogenesis of early endometriosis and endometriosis-associated infertility.
Zhang
Xinmei
X
Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Xu
Hong
H
Lin
Jun
J
Qian
Yuli
Y
Deng
Lin
L
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry*; D016022:Case-Control Studies; D004715:Endometriosis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism*; D008597:Menstrual Cycle / Q000502:physiology; D011446:Prospective Studies
D020381:Interleukin-17