Lithium chloride: an active and simple catalyst for cyanosilylation of aldehydes and ketones.
LiCl acts as a highly effective catalyst for cyanosilylation of various aldehydes and ketones to the corresponding silylated cyanohydrins. The reaction proceeds smoothly with a substrate/catalyst molar ratio of 100-100,000 at 20-25 degrees C under solvent-free conditions. alpha,beta-Unsaturated aldehydes are completely converted to the 1,2-adducts. The cyanation products can be isolated by direct distillation of the reaction mixture.
Kurono
Nobuhito
N
Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan.
Yamaguchi
Masayo
M
Suzuki
Ken
K
Ohkuma
Takeshi
T