Impact of hypertension and apolipoprotein E4 on poststroke cognition in subjects >75 years of age.
OBJECTIVE
The apolipoprotein E4 allele (APOE4) associates with increased dementia risk, and hypertension may associate with mild cognitive deficits. We examined whether nondemented stroke patients with (1) a prestroke history of hypertension and (2) APOE4 were more cognitively impaired at 3 months after stroke.


METHODS
A total of 257 participants were genotyped and outcomes from neuropsychological evaluations analyzed using regression.


RESULTS
Total Cambridge Assessment for Mental Disorders in the Elderly (CAMCOG) and speed of working memory significantly associated with hypertension. No outcomes significantly associated with APOE4.


CONCLUSIONS
Subjects with prestroke hypertension had more impaired global cognition and slower access to information held in working memory.
Rowan
E
E
Institute for Aging and Health, University of Newcastle upon Tyne, UK. e.n.rowan@ncl.ac.uk
Morris
C M
CM
Stephens
S
S
Ballard
C
C
Dickinson
H
H
Rao
H
H
Saxby
B K
BK
McLaren
A T
AT
Kalaria
R N
RN
Kenny
R A
RA
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001281:Atrial Fibrillation / Q000235:genetics; D003071:Cognition; D003072:Cognition Disorders / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012737:Sex Factors; D020521:Stroke / Q000235:genetics* / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4; D001057:Apolipoproteins E