title: Macular thickness after cataract surgery with intracameral cefuroxime.
abstract: OBJECTIVE
  To determine whether the use of prophylactic intracameral cefuroxime during phacoemulsification cataract surgery is associated with increased macular thickening in the postoperative period.
  
  
  METHODS
  Hull and East Yorkshire Eye Hospital, Hull, United Kingdom.
  
  
  METHODS
  In this prospective randomized double-masked clinical study, the study group received 1 mg of intracameral cefuroxime and the control group received intracameral balanced salt solution only. Ocular coherence tomography was performed 5 (+/-1) weeks after surgery.
  
  
  RESULTS
  Intracameral cefuroxime did not have a statistically significant effect on postoperative macular thickness compared with nonadministration of intracameral antibacterials. All patients in both groups achieved a postoperative best corrected visual acuity of 6/9 or better.
  
  
  CONCLUSIONS
  Use of 1 mg of intracameral cefuroxime was not associated with increased macular thickness 4 weeks to 6 weeks postoperatively.
authors.affiliation: Hull and East Yorkshire Eye Hospital, Hull, Yorkshire, UK. sgupta6502@aol.com
authors.forename: Mamta S
authors.initials: MS
authors.lastname: Gupta
authors.forename: Hamish D R
authors.initials: HD
authors.lastname: McKee
authors.forename: Manuel
authors.initials: M
authors.lastname: Saldaña
authors.forename: Owen G
authors.initials: OG
authors.lastname: Stewart
mesh_terms: D000085:Acetates / Q000008:administration & dosage; D000867:Anterior Chamber / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002444:Cefuroxime / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D019654:Lens Implantation, Intraocular; D008269:Macular Edema / Q000139:chemically induced / Q000175:diagnosis; D008903:Minerals / Q000008:administration & dosage; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012965:Sodium Chloride / Q000008:administration & dosage; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; C030660:BSS solution; D004338:Drug Combinations; D008903:Minerals; D012965:Sodium Chloride; D002444:Cefuroxime