title: SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization.
abstract: CONCLUSIONS
  SpA is a web-accessible system for the management, visualization and statistical analysis of T-cell receptor spectratype data. Users upload data from their spectratype analyzers to SpA, which saves the raw data and user-defined supplementary covariates to a secure database. The statistical engine performs several data analyses and statistical summaries. The visualization engine displays spectratype histograms in a Java applet and in an image file suitable for download. All of these results are also saved to the database and remain accessible to the user. Additional statistical tools specific to the analysis of multiple spectratypes are also available through the SpA interface.
  
  
  BACKGROUND
  The service is freely accessible via the web at http://www.duke.edu/~kepler/spa.html. Additional technical support and specialized statistical analysis and consultation are available by arrangement with the authors and, depending on the service requested, may be subject to fee.
authors.affiliation: Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27708, USA.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.forename: John K
authors.initials: JK
authors.lastname: Tomfohr
authors.forename: Blythe H
authors.initials: BH
authors.lastname: Devlin
authors.forename: Marcella
authors.initials: M
authors.lastname: Sarzotti
authors.forename: M Louise
authors.initials: ML
authors.lastname: Markert
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Kepler
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D017931:DNA Primers / Q000737:chemistry; D003628:Database Management Systems; D030562:Databases, Protein; D019672:Genes, T-Cell Receptor / Q000235:genetics; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011381:Programming Languages; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface
chemical_list: D017931:DNA Primers; D011948:Receptors, Antigen, T-Cell