Firing up mitochondrial activities with PTPMT1.
Pagliarini et al (2005) recently identified a new mitochondrial specific protein tyrosine phosphatase, PTPMT1. This report comments on its consequences for mitochondrial function and on its potential to act as a therapeutic target in diabetes and cancer.
Boisclair
Yves
Y
Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA.
Tremblay
Michel L
ML
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000628:therapy; D015870:Gene Expression; D006801:Humans; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000201:enzymology / Q000378:metabolism; D050356:Lipid Metabolism; D008928:Mitochondria / Q000201:enzymology* / Q000502:physiology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000628:therapy; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D000255:Adenosine Triphosphate; D017027:Protein Tyrosine Phosphatases