Recombinant proteins of Cryptosporidium parvum induce proliferation of mesenteric lymph node cells in infected mice.
Recombinant antigens of Cryptosporidium parvum, Cp900 and Cp40 but not Cp15, stimulated C. parvum-specific proliferative immune responses of mesenteric lymph node cells in C57BL/6J mice infected with different isolates (MD, GCH1, UCP, and IOWA) of C. parvum, indicating that both Cp900 and Cp40 are immunodominant targets of cellular immune responses during C. parvum infection.
Singh
Inderpal
I
Division of Infectious Diseases, Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA. inderpal.singh@tufts.edu
Theodos
Cynthia
C
Tzipori
Saul
S
D000818:Animals; D049109:Cell Proliferation; D016785:Cryptosporidium parvum / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008198:Lymph Nodes / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
C094890:CP15 protein, Cryptosporidium parvum; D015800:Protozoan Proteins; D011994:Recombinant Proteins