Microcracks in cortical bone: how do they affect bone biology?
Microcrack accumulation in cortical bone has been implicated in skeletal fragility and stress fractures. These cracks have also been shown to affect the mechanical and material properties of cortical bone. Their growth has been linked to osteocyte apoptosis and the initiation of the remodeling process, which also has a role in their repair. Clinically, osteoporosis is diagnosed using dual energy x-ray absorptiometry. However, evidence now indicates that bone mass alone is insufficient to satisfactorily explain the skeletal fragility of osteoporosis and consideration needs to be given to bone quality in the diagnosis and treatment of the disease. Bone quality includes parameters such as trabecular and cortical microarchitecture, morphology, bone turnover, degree of mineralization of the bone matrix, and significantly, the amount of microdamage present in the bone. Current clinical treatments concentrate on the inhibition of osteoclast activity to maintain bone mass in osteoporotic patients. However, these cells have a major role in removing existing microcracks from the bone matrix, and hence the use of bone resorption- inhibiting drugs may lead to insufficient bone repair and therefore an increase in microdamage accumulation and loss of bone quality.
O'Brien
Fergal J
FJ
Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland. fjobrien@rcsi.ie
Brennan
Orlaith
O
Kennedy
Oran D
OD
Lee
T Clive
TC
D000818:Animals; D001857:Bone Matrix / Q000473:pathology; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D012968:Etidronic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D050723:Fractures, Bone / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D010011:Osteocytes / Q000473:pathology / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D000068296:Risedronic Acid; D013314:Stress, Mechanical
D002121:Calcium Channel Blockers; D000068296:Risedronic Acid; D012968:Etidronic Acid