Are those phospholipids in your pocket?
The identification of phospholipids ligands for the nuclear receptors SF-1 and LRH-1 raise exciting new questions in the areas of signaling and metabolism. Do these receptors provide cells with a mechanism to alter genomic activities in response to phospholipid flux? The tools now exist to address these questions, and more.
Forman
Barry Marc
BM
Gene Regulation and Drug Discovery, The Beckman Research Institute at The City of Hope National Medical Center, Gonda Diabetes Research Center, 1500 East Duarte Road, Duarte, California 91010, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins; D006801:Humans; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology*; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C082631:NR5A2 protein, human; D010743:Phospholipids; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors