title: DISC1 and neurocognitive function in schizophrenia.
abstract: We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%-4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA. kburdick@lij.edu
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Burdick
authors.forename: Colin A
authors.initials: CA
authors.lastname: Hodgkinson
authors.forename: Philip R
authors.initials: PR
authors.lastname: Szeszko
authors.forename: Todd
authors.initials: T
authors.lastname: Lencz
authors.forename: Jenny M
authors.initials: JM
authors.lastname: Ekholm
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
authors.forename: David
authors.initials: D
authors.lastname: Goldman
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003071:Cognition / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012306:Risk; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*; D014706:Verbal Learning / Q000502:physiology
chemical_list: C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins