Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation.
Despite recent advances in understanding the immunopathogenesis of oral lichen planus (LP), the initial triggers of lesion formation and the essential pathogenic pathways are unknown. It is therefore not surprising that the clinical management of oral LP poses considerable difficulties to the dermatologist and the oral physician. A consensus meeting was held in France in March 2003 to discuss the most controversial aspects of oral LP. Part 1 of the meeting report focused on (1) the relationship between oral LP and viral infection, with special emphasis on hepatitis C virus (HCV), and (2) oral LP pathogenesis, in particular the immune mechanisms resulting in lymphocyte infiltration and keratinocyte apoptosis. Part 2 focuses on patient management and therapeutic approaches and includes discussion on malignant transformation of oral LP.
Lodi
Giovanni
G
Department of Medicine, Surgery, and Dentistry, University of Milan, Italy. giovanni.lodi@unimi.it
Scully
Crispian
C
Carrozzo
Marco
M
Griffiths
Mark
M
Sugerman
Philip B
PB
Thongprasom
Kobkan
K
D002471:Cell Transformation, Neoplastic; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D017676:Lichen Planus, Oral / Q000188:drug therapy* / Q000473:pathology*; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology*
D007166:Immunosuppressive Agents