Assessment of potential application of binary mixtures of 2,4-d with novel aminophosphonates.
A series of new aminoalkane- and aminofluorenephosphonates was synthesized for agrochemical application. The particular compounds had different alkyl substituents at the carbon, nitrogen and phosphorus atoms. Their pesticidal activity was checked by applying various experimental methods. These included the measurements of compounds' potency: to inhibit growth of cucumber and germination of white mustard seeds, to influence on the membrane potential of algae and to damage human erythrocyte membranes resulting in hemolysis. All the aminophosphonates were also used in equimolar binary mixtures with the well-known herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), to check, if using such mixtures, the biological efficiencies found for particular compounds could be enhanced due to interactions between aminophosphonates and 2,4-D. The results demonstrated, that depending on the structural features of the compounds, the final effects differed from antagonistic, through additive to the most promising synergistic ones. However, the type of interaction between 2,4-D and the compounds studied found in different experiments was somewhat different. In order to estimate those effects various statistical methods were used (toxic unit method, isobole method).
Sarapuk
Janusz
J
Department of Physics and Biophysics, Agricultural University, Norwida, Poland. js@ozi.ar.wroc.pl
Klesczyńska
Halina
H
Bonarska
Dorota
D
Bielecki
Krzysztof
K
Trela
Zenon
Z
Kordas
Leszek
L
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D018553:Cucumis sativus / Q000187:drug effects*; D004338:Drug Combinations; D005449:Fluorenes / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D063065:Organophosphonates / Q000494:pharmacology*; D010575:Pesticides / Q000138:chemical synthesis* / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*
D004338:Drug Combinations; D005449:Fluorenes; D006540:Herbicides; D063065:Organophosphonates; D010575:Pesticides; D011437:Propylamines; D015084:2,4-Dichlorophenoxyacetic Acid