title: Thrombophilic abnormalities and recurrence of venous thromboembolism in patients treated with standardized anticoagulant treatment.
abstract: BACKGROUND
  Whether patients with hereditary or acquired thrombophilia have an increased risk for recurrence of venous thromboembolism (deep vein thrombosis and/or pulmonary embolism) is still controversial. The aim of this study was to evaluate the incidence of recurrence of venous thromboembolism in patients with and without thrombophilic abnormalities treated with standardized anticoagulant treatment.
  
  
  METHODS
  Database was from a prospective multicenter randomized study aimed at evaluating the long-term clinical benefit of extending to 1 year the 3-month oral anticoagulant treatment after a first episode of idiopathic proximal deep vein thrombosis. The screening for thrombophilia included antithrombin, protein C, protein S deficiencies, resistance to activated protein C and/or factor V R506Q mutation, the mutation 20210GA of the prothrombin gene, hyperhomocysteinemia and antiphospholipid antibodies. The diagnosis of venous thromboembolism recurrence was done by objective tests and adjudicated by a panel unaware of the results of the thrombophilia screening.
  
  
  RESULTS
  A screening for thrombophilic abnormalities was performed in 195 patients. Twenty of 57 (35.1%) thrombophilic patients experienced a recurrence of venous thromboembolism as compared with 29 of 138 (21.0%) patients without thrombophilia (HR=1.78, 95% CI 1.002-3.140, p=0.046). The difference in VTE recurrence between patients with and without thrombophilia was accounted for by those who received 3 months of oral anticoagulation (HR=3.21, 95% CI 1.349-7.616, p=0.008). No difference between thrombophilic and non-thrombophilic patients was observed in the time interval from the index episode to recurrent venous thromboembolism (29.1+/-23.9 and 30.6+/-19.8 months, respectively).
  
  
  CONCLUSIONS
  Thrombophilic abnormalities are associated with an increased risk of venous thromboembolism recurrence. The role of thrombophilia in the long-term management of venous thromboembolism should be addressed in prospective management studies.
authors.affiliation: Sezione di Medicina Interna e Cardiovascolare, Dipartimento di Medicina Interna, Università di Perugia, Via Enrico Dal Pozzo, 06123 Perugia, Italy.
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Santamaria
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Agnelli
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Taliani
authors.forename: Paolo
authors.initials: P
authors.lastname: Prandoni
authors.forename: Marco
authors.initials: M
authors.lastname: Moia
authors.forename: Mario
authors.initials: M
authors.lastname: Bazzan
authors.forename: Giuliana
authors.initials: G
authors.lastname: Guazzaloca
authors.forename: Walter
authors.initials: W
authors.lastname: Ageno
authors.forename: Adriano
authors.initials: A
authors.lastname: Bertoldi
authors.forename: Mauro
authors.initials: M
authors.lastname: Silingardi
authors.forename: Cristina
authors.initials: C
authors.lastname: Tomasi
authors.forename: Giovan Battista
authors.initials: GB
authors.lastname: Ambrosio
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies; D013923:Thromboembolism / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants