title: Manganese superoxide dismutase in pathogenic fungi: an issue with pathophysiological and phylogenetic involvements.
abstract: Manganese-containing superoxide dismutases (MnSODs) are ubiquitous metalloenzymes involved in cell defence against endogenous and exogenous reactive oxygen species. In fungi, using this essential enzyme for phylogenetic analysis of Pneumocystis and Ganoderma genera, and of species selected among Ascomycota, Basidiomycota and Zygomycota, provided interesting results in taxonomy and evolution. The role of mitochondrial and cytosolic MnSODs was explored in some pathogenic Basidiomycota yeasts (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. gattii, Malassezia sympodialis), Ascomycota filamentous fungi (Aspergillus fumigatus), and Ascomycota yeasts (Candida albicans). MnSOD-based phylogenetic and pathogenic data are confronted in order to evaluate the roles of fungal MnSODs in pathophysiological mechanisms.
authors.affiliation: ECOPA (EA 3609), Lille Pasteur Institute, France. emilie.frealle@pasteur-lille.fr
authors.forename: Emilie
authors.initials: E
authors.lastname: Fréalle
authors.forename: Christophe
authors.initials: C
authors.lastname: Noël
authors.forename: Eric
authors.initials: E
authors.lastname: Viscogliosi
authors.forename: Daniel
authors.initials: D
authors.lastname: Camus
authors.forename: Eduardo
authors.initials: E
authors.lastname: Dei-Cas
authors.forename: Laurence
authors.initials: L
authors.lastname: Delhaes
mesh_terms: D001203:Ascomycota / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D001487:Basidiomycota / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D009181:Mycoses / Q000382:microbiology / Q000503:physiopathology*; D010802:Phylogeny; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase