title: Evaluation of insulin sensitivity in patients with Klinefelter's syndrome: a hyperinsulinemic euglycemic clamp study.
abstract: Patients with Klinefelter's syndrome have a higher incidence of diabetes mellitus and the percentage of insulin resistance was reported to be high in these patients. However, little is known about the insulin sensitivity assessed by the hyperinsulinemic euglycemic clamp in these patients. In the present study, subjects included 13 newly diagnosed patients with Klinefelter's syndrome, and 9 age- and body mass index-matched healthy males. The hyperinsulinemic euglycemic clamp was performed in all patients and controls. Insulin resistance was present in five (38.5%) patients with Klinefelter's syndrome. Compared with control subjects, patients with Klinefelter's syndrome had elevated plasma concentrations of fasting insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin, whereas they had reduced plasma free testosterone and total testosterone concentrations. The multivariate linear regression analysis showed that fasting glucose, fasting insulin, free testosterone, and total testosterone were independently associated with M-value. In conclusion, the present study by using hyperinsulinemic euglycemic clamp indicates the high prevalence of insulin resistance in Klinefelter's syndrome patients. However, these patients did not have reduced mean M-values compared with the controls, although their plasma insulin levels were significantly elevated. It is possible that hyperinsulinemia may be the primary metabolic abnormality rather than insulin resistance.
authors.affiliation: Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yesilova
authors.forename: Cagatay
authors.initials: C
authors.lastname: Oktenli
authors.forename: S Yavuz
authors.initials: SY
authors.lastname: Sanisoglu
authors.forename: Ugur
authors.initials: U
authors.lastname: Musabak
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Metin
authors.initials: M
authors.lastname: Ozata
authors.forename: Kemal
authors.initials: K
authors.lastname: Dagalp
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015309:Glucose Clamp Technique; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007713:Klinefelter Syndrome / Q000503:physiopathology*; D008297:Male
chemical_list: D012739:Gonadal Steroid Hormones