title: Eleven new 2-pyrones from a Fungi Imperfecti, Trichurus terrophilus, found in a screening study guided by immunomodulatory activity.
abstract: In a screening study on immunomodulatory fungal constituents, eleven new 2-pyrones tentatively named TT-1 (1), and TT-2-11 (2-11) have been isolated from a Fungi Imperfecti, Trichurus terrophilus, and designated rasfonin (1), and trichurusin B-K (2-11), respectively. Compounds 1-4 exhibited considerably high immunosuppressive activities, and compounds 8-11 have shown moderate ones. The structure-activity relationships of these constituents have also been discussed.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. fujimoto@p.chiba-u.ac.jp
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Eriko
authors.initials: E
authors.lastname: Sone
authors.forename: Satomi
authors.initials: S
authors.lastname: Maeda
authors.forename: Kohki
authors.initials: K
authors.lastname: Akiyama
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D007155:Immunologic Factors; D011753:Pyrones