title: Association of HLA DQB1 0602 in sarcoidosis patients with small fiber neuropathy.
abstract: OBJECTIVE
  Sarcoidosis has been reported to be associated with the HLA genes, in particular DQB1.
  
  
  METHODS
  High resolution DQB 1 of 103 sarcoidosis patients was obtained by sequence-based typing; low resolution HLA-A/B/DRB 1 typing was performed by serological and molecular methods. Small fiber neuropathy (SFN) was established by thermal threshold testing.
  
  
  RESULTS
  Sixty-seven patients suffered from SFN (SFN+), in 36 patients SFN was absent (SFN-). Comparing HLA DQB 1 typings of SFN+ patients, SFN- patients and control individuals revealed a significant increase of the allele DQB 1 0602 in SFN+ patients compared to controls.
  
  
  CONCLUSIONS
  This association might be correlated with a severe course of the disease.
authors.affiliation: Tissue Typing Laboratory, University Hospital Maastricht, The Netherlands.
authors.forename: Christina E M
authors.initials: CE
authors.lastname: Voorter
authors.forename: Marjolein
authors.initials: M
authors.lastname: Drent
authors.forename: Elske
authors.initials: E
authors.lastname: Hoitsma
authors.forename: Karin G
authors.initials: KG
authors.lastname: Faber
authors.forename: Ella M
authors.initials: EM
authors.lastname: van den Berg-Loonen
mesh_terms: D000328:Adult; D000483:Alleles; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000235:genetics* / Q000276:immunology; D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010641:Phenotype; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000150:complications / Q000235:genetics* / Q000276:immunology
chemical_list: D005819:Genetic Markers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D004247:DNA