[Study on independent factors on the prognosis of colorectal carcinoma: TNM stage, tumor budding, perineural invasion, peritumoral-lymphocytic infiltration and urine glucose].
OBJECTIVE
To study the influence of clinical and pathological-morphological parameters on the prognosis of colorectal carcinoma.


METHODS
Univariate and multivariate Cox proportional hazard model were used to study the influence of clinical and pathological-morphological factors on the prognosis in 226 colorectal carcinoma cases.


RESULTS
Using univariate analysis, data showed that the factors significantly related to disease prognosis would include: the depth of direct spread, vessel invasion, perineural invasion, tumor budding, peritumoral-lymphocytic infiltration, Crohn-like reaction, number of positive lymph nodes, distant metastasis, TNM stage and urine glucose. Multivariate Cox proportional hazard model showed that six factors were identified to be associated with higher relative-risk (RR), including: older age, advanced TNM stage, more severe budding, perineural invasion, less peritumoral-lymphocytic infiltration and urine glucose.


CONCLUSIONS
Age, TNM stage, tumor budding, perineural invasive, peritumoral-lymphocytic infiltration and urine glucose were independent predictors to the prognosis of colorectal carcinoma.
Xu
Fang-ying
FY
Department of Pathology and Pathophysiology, Centre for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China.
Dong
Jian-kang
JK
Zhu
Yi-min
YM
Qu
Mei-juan
MJ
Wang
Fen-juan
FJ
Jin
Yi-sen
YS
Ren
Guo-ping
GP
Lai
Mao-de
MD
D000368:Aged; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006029:Glycosuria; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors