Effect of human interferon preparations on lymphoblastogenesis in Down's syndrome.
The best characterised properties of human interferon, its antiviral (AV) and cell multiplication inhibitory (CMI) activities, are controlled, in an unexplained manner, by genes on chromosomes 21 (refs 1-4; 14-16). Human and animal interferons have various immunosuppressive effects, among them the inhibition in vitro of DNA synthesis in activated lymphocytes. Using mitogen- and antigen-stimulated lymphocytes from normal subjects (disomic 21) and others with Down's syndrome (trisomic 21), we have found that DNA synthesis is inhibited to a greater degree in the latter by both fibroblastoid and leukocyte interferons. We suggest that this property is also regulated by genes on chromosome 21.
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Department of Medical Biochemistry and Pediatrics, University of Calgary, Alberta, Canada.
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D049109:Cell Proliferation / Q000187:drug effects; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004247:DNA / Q000032:analysis / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects; D004314:Down Syndrome / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology / Q000494:pharmacology; D007372:Interferons / Q000276:immunology / Q000494:pharmacology*; D007621:Karyotyping; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology
D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D004247:DNA; D007372:Interferons