title: Global physiological understanding and metabolic engineering of microorganisms based on omics studies.
abstract: Through metabolic engineering, scientists seek to modify the metabolic pathways of living organisms to facilitate optimized, efficient production of target biomolecules. During the past decade, we have seen notable improvements in biotechnology, many of which have been based on metabolically engineered microorganisms. Recent developments in the fields of functional genomics, transcriptomics, proteomics, and metabolomics have changed metabolic engineering strategies from the local pathway level to the whole system level. This article focuses on recent advances in the field of metabolic engineering, which have been powered by the combined approaches of the various "omics" that allow us to understand the microbial metabolism at a global scale and to develop more effectively redesigned metabolic pathways for the enhanced production of target bioproducts.
authors.affiliation: Corporate R&D, LG Chem, Ltd./Research Park, Yuseong-gu, Daejeon, Republic of Korea. park_sj@lgchem.com
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
authors.forename: S Y
authors.initials: SY
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Cho
authors.forename: T Y
authors.initials: TY
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: M-J
authors.initials: MJ
authors.lastname: Han
mesh_terms: D001698:Biomedical Engineering / Q000639:trends*; D001709:Biotechnology / Q000639:trends; D005786:Gene Expression Regulation; D005818:Genetic Engineering; D016678:Genome; D016680:Genome, Bacterial; D016681:Genome, Fungal; D015202:Protein Engineering / Q000379:methods*; D020543:Proteome / Q000032:analysis*; D011994:Recombinant Proteins / Q000096:biosynthesis*
chemical_list: D020543:Proteome; D011994:Recombinant Proteins