title: [Toxocariasis in children from a subtropical region].
abstract: Toxocariasis is present worldwide but people living in areas with sanitary deficiencies are considered at the highest risk of infection, particularly children. The aim of this work was to know clinical and immunological aspects of infantile toxocariasis in a subtropical region in Argentina. For this purpose, 182 children of both sexes, 0-16 years old and with eosinophilia higher than 10%, living in Resistencia City (Northeast Argentina) were studied. Clinical examination, personal and epidemiological data recording, parasitological fecal examination and dosage of Toxocara canis IgG and IgM levels by EIE were performed; all positive sera were confirmed by Western Blot. Out of 182 children, 122 were positive for T. canis-IgG (67.0%); 28.8% lack of potable drinking water at home, 58.8% lack of sewerage facilities, 91.1% referred a close contact with dogs or cats, 30.0% had a history of geophagia and 86.7% lived along streets without pavement. The clinical forms of the infection were: 77.8% asymptomatic, 6.7% ocular larva migrans and 15.5% visceral larva migrans. In 22 children the serological follow up until 18 months after treatment showed 10 children without change in IgG levels, in 11 it decreased but remained high, and in one it increased. There were 19 children with high levels of T. canis-IgM; in 8 it decreased along treatment, in one it remained stable and 10 of them became negative. There was one child considered as a re-infection case. Results highlight the importance that health authorities should assign to this infection in regions with sanitary deficiencies, where toxocariasis is usually not recognized as a relevant public health problem.
authors.affiliation: Area de Inmunología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Argentina.
authors.forename: Maria De Los Angeles
authors.initials: Mde L
authors.lastname: Lopez
authors.forename: Graciela
authors.initials: G
authors.lastname: Martin
authors.forename: Myrian Del Carmen
authors.initials: Mdel C
authors.lastname: Chamorro
authors.forename: Jose
authors.initials: J
authors.lastname: Mario Alonso
mesh_terms: D000293:Adolescent; D000818:Animals; D001118:Argentina / Q000453:epidemiology; D002415:Cats; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D004285:Dogs; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007815:Larva Migrans / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D007816:Larva Migrans, Visceral / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D017166:Toxocara canis / Q000276:immunology*; D014120:Toxocariasis / Q000097:blood / Q000453:epidemiology / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M