title: Randomized, prospective comparison of postoperative pain in low- versus high-pressure pneumoperitoneum.
abstract: BACKGROUND
  Reduced postoperative pain after laparoscopic cholecystectomy (LC) compared to open cholecystectomy (OC) may be able to be further optimized. To reduce pain, focus should be directed on the effects of individual components of pain.
  
  
  METHODS
  A double-blind, randomized, controlled trial was carried out in a tertiary care hospital. Fifty-three elective patients with symptomatic gallstones were enrolled into the study. Patients were randomized to low- or high-pressure pneumoperitoneum groups. In all patients, gas pressure was set to 15 mmHg during placement of ports. Later on, in the low-pressure group, the rest of the procedure was performed at 10 mmHg pressure. At 6 and 24 h postoperatively, a short-form McGill Questionnaire (MPQ) was obtained from all patients. Patients were then asked to complete a 10-cm visual analogue scale (VAS) for abdominal pain.
  
  
  RESULTS
  Pain scores were generally low for both groups. Statistical comparisons of mean cumulative McGill score and VAS abdominal pain scores in both groups did not reach statistical significance at 6 and 24 h after operation.
  
  
  CONCLUSIONS
  There was no correlation between high- and low-pressure laparoscopy and postoperative pain after LC. Peritoneal stretching may be more responsible for shoulder pain but has less effect on intensity of abdominal pain or incisional pain. On the basis of these negative findings, routine use of low-pressure pneumoperitoneum for alleviation of postoperative pain following LC is not recommended.
authors.affiliation: Fifth Department of Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Koc
authors.forename: Tamer
authors.initials: T
authors.lastname: Ertan
authors.forename: Mesut
authors.initials: M
authors.lastname: Tez
authors.forename: M Ali
authors.initials: MA
authors.lastname: Kocpinar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kilic
authors.forename: Erdal
authors.initials: E
authors.lastname: Gocmen
authors.forename: A Kessaf
authors.initials: AK
authors.lastname: Aslar
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D017081:Cholecystectomy, Laparoscopic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology*; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects* / Q000379:methods; D011312:Pressure