title: Cytotoxic diterpenoids from the soft coral Sinularia microclavata.
abstract: The soft coral Sinularia microclavata collected from the bay of Sanya, Hainan Island, China, yielded a new diterpenoid, microclavatin (1), and a known cembranolide, capillolide (2). The structure of compound 1 was determined on the basis of spectroscopic methods and X-ray single-crystal diffraction analysis. Microclavatin (1) showed cytotoxic activities against tumor cell lines KB and MCF with IC50 values of 5.0 and 20.0 microg/mL, respectively, and capillolide (2) showed potent cytotoxic activity against tumor cell lines (A-549) with an IC50 value of 0.5 microg/mL.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China.
authors.forename: Cui-Xian
authors.initials: CX
authors.lastname: Zhang
authors.forename: Su-Jun
authors.initials: SJ
authors.lastname: Yan
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Zhang
authors.forename: Wei-Gang
authors.initials: WG
authors.lastname: Lu
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Su
authors.forename: Long-Mei
authors.initials: LM
authors.lastname: Zeng
authors.forename: Liang-Quan
authors.initials: LQ
authors.lastname: Gu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Yang
authors.forename: Yong-Ju
authors.initials: YJ
authors.lastname: Lian
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C420035:capillolide; C503026:microclavatin