Cytotoxic diterpenoids from the soft coral Sinularia microclavata.
The soft coral Sinularia microclavata collected from the bay of Sanya, Hainan Island, China, yielded a new diterpenoid, microclavatin (1), and a known cembranolide, capillolide (2). The structure of compound 1 was determined on the basis of spectroscopic methods and X-ray single-crystal diffraction analysis. Microclavatin (1) showed cytotoxic activities against tumor cell lines KB and MCF with IC50 values of 5.0 and 20.0 microg/mL, respectively, and capillolide (2) showed potent cytotoxic activity against tumor cell lines (A-549) with an IC50 value of 0.5 microg/mL.
Zhang
Cui-Xian
CX
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, People's Republic of China.
Yan
Su-Jun
SJ
Zhang
Guang-Wen
GW
Lu
Wei-Gang
WG
Su
Jing-Yu
JY
Zeng
Long-Mei
LM
Gu
Liang-Quan
LQ
Yang
Xiao-Ping
XP
Lian
Yong-Ju
YJ
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; C420035:capillolide; C503026:microclavatin