Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis.
This prospective study, performed in 76 children with a urinary tract infection (UTI), evaluates the diagnostic value of procalcitonin (PCT) and proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) in children with acute pyelonephritis documented by dimercaptosuccinic acid scintigraphy (DMSA). Renal parenchymal involvement was assessed by (99m )Tc-DMSA scintigraphy within 7 days of admission. The diagnosis of acute pyelonephritis was confirmed only in patients with reversible lesions on scintigraphy. According to DMSA scan results, patients were divided into two groups, lower UTI or acute pyelonephritis. In acute pyelonephritis, serum PCT level was found to be significantly higher than it is in the lower UTI (p <0.001). Also, significantly higher serum proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) levels were detected in those with acute pyelonephritis than those with lower UTI (p <0.001). We conclude that both serum PCT and proinflammatory cytokine levels may be used as accurate markers for diagnosis of acute pyelonephritis.
Gürgöze
Metin Kaya
MK
Department of Pediatrics, Firat University Faculty of Medicine, Elazig, Turkey. mkgurgoze@yahoo.com
Akarsu
Saadet
S
Yilmaz
Erdal
E
Gödekmerdan
Ahmet
A
Akça
Zehra
Z
Ciftçi
Ismail
I
Aygün
A Denizmen
AD
D000208:Acute Disease; D001424:Bacterial Infections; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007668:Kidney / Q000000981:diagnostic imaging; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000473:pathology; D011498:Protein Precursors / Q000097:blood*; D011704:Pyelonephritis / Q000097:blood* / Q000000981:diagnostic imaging / Q000382:microbiology; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014463:Ultrasonography; D014552:Urinary Tract Infections / Q000175:diagnosis
C000606589:CALCA protein, human; D018836:Inflammation Mediators; D007375:Interleukin-1; D015850:Interleukin-6; D011498:Protein Precursors; D014409:Tumor Necrosis Factor-alpha; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide