title: JBMR anniversary classic. Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. Originally published in Volume 7, number 4, pp 581-9 (1998).
authors.forename: Steven P
authors.initials: SP
authors.lastname: Luckman
authors.forename: David E
authors.initials: DE
authors.lastname: Hughes
authors.forename: Fraser P
authors.initials: FP
authors.lastname: Coxon
authors.forename: Graham G
authors.initials: GG
authors.lastname: Russell
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rogers
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000266:history* / Q000378:metabolism; D002478:Cells, Cultured; D004164:Diphosphonates / Q000266:history* / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000266:history / Q000378:metabolism; D049673:History, 20th Century; D008148:Lovastatin / Q000031:analogs & derivatives / Q000266:history / Q000494:pharmacology; D008798:Mevalonic Acid / Q000266:history* / Q000378:metabolism; D051379:Mice; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D017368:Protein Prenylation / Q000187:drug effects; D018631:ras Proteins / Q000266:history* / Q000378:metabolism
chemical_list: D004164:Diphosphonates; C012258:mevastatin; D008148:Lovastatin; D019204:GTP-Binding Proteins; D018631:ras Proteins; D008798:Mevalonic Acid