Ileocolic free flap reconstruction, concomitant chemotherapy and radiotherapy and assessment of speech and swallowing function during management of advanced cancer of the larynx and hypopharynx: preliminary report.
CONCLUSIONS
The new technique of ileocolic free flap reconstruction provides a better quality of life in terms of swallowing and speech for patients who have undergone laryngopharyngectomy with concomitant chemotherapy and radiotherapy (CCRT).


OBJECTIVE
To compare and contrast the swallowing and speech outcomes of patients who underwent total laryngopharyngectomy with ileocolic free flap reconstruction and to analyze the survival rate after surgery and CCRT.


METHODS
This was a follow-up study of 12 patients with advanced (stages III, IVA and IVB) laryngeal and hypopharyngeal cancer who underwent major surgery, CCRT (with one exception) and ileocolic free flap reconstruction.


RESULTS
All patients were able to tolerate single-stage combined management comprising total laryngopharyngectomy with or without radical neck dissection plus ileocolic free flap reconstruction and postoperative CCRT (with one exception), without immediate morbidity or mortality. Eleven patients were diagnosed with hypopharyngeal cancer and one with laryngeal cancer. The mean interval between surgery and CCRT was 34.1 days. The mean follow-up period was 16.5 months. Four patients died during the follow-up period as a result of local recurrence (n=2), distant metastasis (n=1) and suicide (n=1). One patient was alive with disease despite neck recurrence.
Leu
Yi-Shing
YS
The Department of Otolaryngology-Head & Neck Surgery, Mackay Memorial Hospital, Taipei, Taiwan. lys@ms2.mmh.org.tw
Hsiao
Hung-Tao
HT
Chang
Yuan-Ching
YC
Yang
Cheng-Chien
CC
Lee
Jehn-Chuan
JC
Chen
Yu-Jen
YJ
Chang
Yi-Fang
YF
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D002423:Cause of Death; D003106:Colon / Q000637:transplantation*; D003679:Deglutition / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D007080:Ileocecal Valve / Q000637:transplantation*; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000534:rehabilitation; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010611:Pharyngectomy / Q000534:rehabilitation; D011788:Quality of Life; D019651:Plastic Surgery Procedures; D013060:Speech / Q000502:physiology*; D013524:Surgical Flaps; D015996:Survival Rate; D016896:Treatment Outcome
D000970:Antineoplastic Agents