Effects of Byakko-ka-ninjin-to on salivary secretion and bladder function in rats.
Byakko-ka-ninjin-to (BN) is a Kampo medicine (traditional Japanese medicine) that is frequently used to treat xerostomia, which is also a side effect of anticholinergic agents such as oxybutynin and propiverine widely used for the treatment of patients with urinary incontinence or frequency. We investigated the effects of BN on salivation and bladder function in rats, in the presence and absence of oxybutynin. Treatment with BN alone resulted in a slight increase in salivary secretions. In contrast, pilocarpine, a known muscarinic agonist, produced a significant increase in salivary secretions that could be blocked by pretreatment with oxybutynin. A single oral dose of BN at 200mg/kg body weight just before oxybutynin treatment resulted in less inhibition by oxybutynin of pilocarpine-induced salivation. However, BN had no effect on the decreased amplitude of bladder contractions that result from oxybutynin administration. These results suggest that BN might be useful for the xerostomia induced by anticholinergic agents, without influencing their beneficial effect on micturition.
Sakaguchi
Masaru
M
Tsumura Research Institute, Medicinal Evaluation Laboratory, Research Division, 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan. sakaguchi.masaru@mail.tsumuru.co.jp
Goto
Kazuhiro
K
Ichiki
Hiroyuki
H
Hattori
Naoko
N
Iizuka
Akira
A
Yamamoto
Masahiro
M
Takeda
Shuichi
S
Ishige
Atsushi
A
Aburada
Masaki
M
Yasuda
Masako
M
Yamamoto
Toshinori
T
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D008333:Mandelic Acids / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010862:Pilocarpine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012472:Salivation / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology; D014987:Xerostomia / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D008333:Mandelic Acids; D010936:Plant Extracts; C108060:byakko-ka-ninjin-to; D010862:Pilocarpine; C005419:oxybutynin