Vitreous leptin levels in retinal disease.
OBJECTIVE
The purpose of this study was to investigate the relationship between vitreous leptin levels and retinal diseases.


METHODS
Levels of vitreous leptin were evaluated in proliferative diabetic retinopathy (PDR) and a variety of other retinopathies including: macular disease, neovascular maculopathies, primary retinal detachments, and vascular occlusive disease.


RESULTS
In patients with PDR (N=7), the average vitreous level of leptin (37.4 ng/ml) was significantly higher than that in patients with PVR (<1.0 ng/ml, P<0.05). Vitreous leptin level in patients with PVR or macular disease (N=18), with or without diabetes, was not significantly different from the control subjects who had retinal detachment only (N=7).


CONCLUSIONS
The results show that the leptin level in vitreous taps is elevated in PDR. We suggest that leptin plays an active role in PDR.
Maberley
D
D
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada. crtg_vancouver@hotmail.com
Cui
J Z
JZ
Matsubara
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012164:Retinal Diseases / Q000378:metabolism* / Q000601:surgery; D012720:Severity of Illness Index; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
D015415:Biomarkers; D020738:Leptin