Molecular organization of the antifungal and anticancer drug 2-(2,4-dihydroxyphenylo)-5,6-dichlorobenzothiazole in solution and in monolayers: an effect of pH.
2-(2,4-Dihydroxyphenylo)-5,6-dichlorobenzothiazol (dHBBT) is a new anticancer, antifungal and antibacterial drug characterised also by cytostatic and anticancer activity. The effect of pH on the molecular organization of dHBBT in monomolecular layers and in solution has been studied by electronic absorption and FT-IR spectroscopies. The analysis of the spectroscopic data suggests that at neutral and at high pH values (pH 6-8) dHBBT appears in the anionic form that prevents the formation of dimers due to the electrostatic repulsion between the molecules.
Gagoś
Mariusz
M
Department of Physics, Agricultural University, Lublin, Poland.
Menestrina
Gianfranco
G
Niewiadomy
Andrzej
A
Gruszecki
Wiesław I
WI
D000935:Antifungal Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D052160:Benzothiazoles / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012118:Resorcinols / Q000737:chemistry*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared
C506216:2-(2,4-dihydroxyphenyl)-5,6-dichlorobenzothiazole; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D052160:Benzothiazoles; D012118:Resorcinols; D012996:Solutions