title: Intermediate versus hard end points in clinical trials on hypertension.
abstract: The main features of randomized clinical trials performed in the field of hypertension treatment are reviewed, based either on the evaluation of clinical events or on the assessment of surrogate outcome measures. The advantages, limitations, and clinical relevance of each approach are highlighted.
authors.affiliation: Clinica Medica, Ospedale S. Gerardo, Via Donizetti 106, 20052 Monza (Milano), Italy. guido.grassi@unimib.it
authors.forename: Guido
authors.initials: G
authors.lastname: Grassi
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents