Successful treatment of Aspergillus prosthetic valve endocarditis with oral voriconazole.
Aspergillus endocarditis is very difficult to cure, even with aggressive surgical debridement and antifungal therapy. Patients with embolic involvement of the central nervous system have an extremely poor prognosis. We describe a patient with prosthetic valve endocarditis due to Aspergillus fumigatus who developed emboli in the brain, eye, and lower extremities. With aggressive surgical debridement of involved sites, aortic valve and root replacement, and long-term therapy with oral voriconazole, he remains without any evidence of infection 2 years later.
Reis
Lisa J
LJ
Hospital of The University of Pennsylvania, Philadelphia, PA, USA.
Barton
Todd D
TD
Pochettino
Alberto
A
Velazquez
Omaida
O
McGarvey
Michael
M
Milas
Bonnie
B
Reboli
Annette
A
Schuster
Mindy G
MG
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy*; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole