title: [Alcohol-induced arterial hypertension and genetic polymorphism of alcohol-metabolizing enzymes].
abstract: OBJECTIVE
  To study arterial pressure (AP) and heart rate (HR) in patients suffering from alcohol withdrawal syndrome (AWS) with relation to genetic polymorphism of alcohol dehydrogenase-2 (ADG2) and aldehyde dehydrogenase-2 (AlDG2).
  
  
  METHODS
  AP and HR were analysed for 36 alcoholics (83 hospitalizations, including repeated ones) with genotypes ADG2 and AIDG2 at admission to and discharge from narcological hospital.
  
  
  RESULTS
  ADG2 genotypes distribution was the following: ADG2-1/1--61.1% (n = 22); ADG2-1/2--36.1% (n = 13); ADG2-2/2--2.8% 9n = 1). All the patients had a genotype AIDG2-1/1. A hypertensive reaction occurred in 75.9% inpatients with AWS. At admission, patients with genotype ADG2-1/1 had significantly higher systolic AP and HR vs those with allele ADG2-2: 146.6 +/- 17.0 mmHg against 141.2 +/- 14.9 mmHg, 95.6 +/- 13.9 b/min vs 88.5 +/- 12.2 b/min, respectively. In homozygous genotype ADG2-1/1 AP and HR were higher than in heterozygotes: SAP 152.3 +/- 12.9 mm Hg vs 145.2 +/- 16.2 mm Hg, pulse pressure 57.2 +/- 11.9 vs 50.0 +/- 15.1 mm Hg, HR 96.8 +/- 13.4 b/min vs 87.7 +/- 12.0 b/min. The groups had similar mean diastolic pressure. At discharge, AWS standard therapy resulted in a significant lowering of AP and HR in the study group. Mean values of the parameters in groups with different genotypes did not differe at discharge.
  
  
  CONCLUSIONS
  Population of alcoholics from the Moscow Region had allele polymorphism ADG2. Genetic polymorphism AlDG2 is not typical for this group. Hypertensive reaction was registered in the majority of alcoholics in AWS. Higher systolic, pulse pressure and heart rate were significantly higher in the AWS group with genotype ADG2-1/1. Controlled alcohol withdrawal entails a significant reduction of AP and HR.
authors.forename: V S
authors.initials: VS
authors.lastname: Moiseev
authors.forename: P P
authors.initials: PP
authors.lastname: Ogurtsov
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Kobalova
authors.forename: N S
authors.initials: NS
authors.lastname: Ovchinnikov
authors.forename: I V
authors.initials: IV
authors.lastname: Garmash
authors.forename: N V
authors.initials: NV
authors.lastname: Mazurchik
authors.forename: G A
authors.initials: GA
authors.lastname: Shipulin
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D001794:Blood Pressure; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000201:enzymology / Q000235:genetics*
chemical_list: D000431:Ethanol; C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial