[Effects of different penetration enhancers on percutaneous absorption of lappaconitine gel in vitro].
OBJECTIVE
To study the effects of different penetration enhancers on the transcutaneous permeability of lappaconitine gel in vitro and therefore to screen out the effective accelerator to enhance the permeation rate of lappaconitine.


METHODS
Using improved Franz-type diffusion cell and excised big mouse skin in vitro as transdermal barrier, the kinetics parameters such as cumulative permeation quantity, permeation rate and permeation lagged time were determined by HPLC. The enhancement ability of four different enhancers such as azone (Azone), propylene glycol (PG), oleic acid (OA) and lauryl alcohol (LA), was investigated when used either uniquely or combinatively each other at random.


RESULTS
When used combinatively, Azone + PG, LA + PG, OA + PG can enhance the cumulative permeation quantity, OA + PG was the best one among them.


CONCLUSIONS
The selection of the best penetration enhancers provided reference for lappaconitine transdermal delivery.
Wang
Ying-zi
YZ
Beijing University of Traditional Chinese Medicine, Beijing 100102, China. wangyzi@sina.com
Ren
Tian-chi
TC
Xiao
Yong-qing
YQ
D000157:Aconitine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000279:Administration, Cutaneous; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D007851:Dodecanol / Q000494:pharmacology; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D019301:Oleic Acid / Q000494:pharmacology*; D019946:Propylene Glycol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption / Q000187:drug effects*
D018712:Analgesics, Non-Narcotic; D001381:Azepines; D004338:Drug Combinations; D007851:Dodecanol; C035229:laurocapram; D019301:Oleic Acid; D019946:Propylene Glycol; D000157:Aconitine; C022150:lappaconitine