title: Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms.
abstract: Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/(on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.
authors.affiliation: UCLA-Geffen School of Medicine, Los Angeles, CA, USA. cmd@mednet.ucla.edu
authors.forename: C
authors.initials: C
authors.lastname: DeGiorgio
authors.forename: C
authors.initials: C
authors.lastname: Heck
authors.forename: S
authors.initials: S
authors.lastname: Bunch
authors.forename: J
authors.initials: J
authors.lastname: Britton
authors.forename: P
authors.initials: P
authors.lastname: Green
authors.forename: M
authors.initials: M
authors.lastname: Lancman
authors.forename: J
authors.initials: J
authors.lastname: Murphy
authors.forename: P
authors.initials: P
authors.lastname: Olejniczak
authors.forename: J
authors.initials: J
authors.lastname: Shih
authors.forename: S
authors.initials: S
authors.lastname: Arrambide
authors.forename: J
authors.initials: J
authors.lastname: Soss
mesh_terms: D003371:Cough / Q000209:etiology; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods* / Q000639:trends; D004566:Electrodes; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D010612:Pharyngitis / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome; D014630:Vagus Nerve / Q000502:physiology* / Q000601:surgery; D014832:Voice Disorders / Q000209:etiology