The 5-HT2C receptor antagonist RO 60-0491 counteracts rats' retention deficits in a recognition memory task.
The effects of the 5-HT2C receptor antagonist RO 60-0491 on recognition memory were investigated in the rat by using the object recognition task. Post-training administration of RO 60-0491 at 3 mg/kg, but not at 1 mg/kg, counteracted rats' performance deficits in the object recognition task, suggesting that this 5-HT2C receptor antagonist compound modulates storage and/or retrieval of information.
Pitsikas
Nikolaos
N
Department of Pharmacology, School of Medicine, University of Thessaly, 22, Papakiriazi str., 412-22 Larissa, Greece. npitsikas@med.uth.gr
Sakellaridis
Nikolaos
N
D000818:Animals; D001522:Behavior, Animal; D004192:Discrimination, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects*; D012153:Retention, Psychology / Q000187:drug effects*; D058830:Serotonin 5-HT2 Receptor Antagonists; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology
D009281:Naphthalenes; C506337:RO 60-0491; D058830:Serotonin 5-HT2 Receptor Antagonists; D014508:Urea