title: [Treatment strategy for children with Wilms tumor].
abstract: Wilms tumor has an excellent prognosis according to the findings of the National Wilms Tumor Study (NWTS). The NWTS has been aiming to reduce the intensity of treatment for low-risk groups. Pathologic assessment or statistical analysis has identified the appropriate staging system suited to this treatment regimen. The Japanese Wilms Tumor Study (JWiTS) has been following the NWTS-5 regimen to increase survival rates and tumor-free survival rates from 1996. This study aims to establish a central review system of pathology and to study the presence of WT1 mutation in tumor samples. In addition, JWiTS focuses on developing an online database that can be shared over the Internet. However, the prognosis in patients with malignant rhabdoid tumor of the kidney (MRTK) is still poor. JWiTS has started to consider a new regimen for MRTK.
authors.affiliation: Division of Pediatric Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fukuzawa
mesh_terms: D002648:Child; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D003131:Combined Modality Therapy; D016162:Genes, Wilms Tumor; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D019656:Loss of Heterozygosity; D009154:Mutation; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D025721:WT1 Proteins / Q000235:genetics; D009396:Wilms Tumor / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy*
chemical_list: D025721:WT1 Proteins