Epidermal growth factor receptor (EGF-R) in Dupuytren's disease.
The aim of this paper was to examine participation of the epidermal growth factor receptor (EGF-R) signal pathway in the pathogenesis of Dupuytren's disease. The study showed changes in the ratio of membrane EGF-R to its intracellular level during the different clinical stages of Dupuytren's contracture progression. Our observations of a high ratio of surface to intracellular EGF-R in the palmar aponeurosis of patients with second degree of Dupuytren's disease (Iselin's classification), which was significantly higher than this ratio in control palmar fascia (P=0.022), would suggest that EGF-R has a role in the involutional phase of the disease.
Augoff
K
K
Department of Traumatic Surgery and Hand Surgery, Medical University, Wrocław, Poland. augoffka@chir.am.wroc.pl
Taboła
R
R
Kula
J
J
Gosk
J
J
Rutowski
R
R
D000368:Aged; D049109:Cell Proliferation; D018450:Disease Progression; D004387:Dupuytren Contracture / Q000473:pathology / Q000503:physiopathology*; D066246:ErbB Receptors / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D066246:ErbB Receptors