title: Cell therapy plus transmyocardial laser revascularization for refractory angina.
abstract: We describe the use of autologous bone marrow cells combined with transmyocardial laser revascularization in a 74-year-old man with refractory angina. Baseline cardiac magnetic resonance imaging revealed a markedly depressed left ventricle systolic function and an extensive area of myocardial ischemia. During surgery, 11 laser shots using a CO2 Heart Laser System (PLC Medical Systems, Milford, MA) were fired and a 5-mL cell suspension containing 21.5 x 10(6) bone marrow cells/mL was delivered by multiple injections into the myocardium. At 6 months after the procedure, another cardiac magnetic resonance imaging showed an almost complete resolution of the perfusion defect and an improvement in left ventricular contractility.
authors.affiliation: Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil. luis.gowdak@incor.usp.br
authors.forename: Luís Henrique W
authors.initials: LH
authors.lastname: Gowdak
authors.forename: Isolmar T
authors.initials: IT
authors.lastname: Schettert
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Rochitte
authors.forename: Luiz Augusto F
authors.initials: LA
authors.lastname: Lisboa
authors.forename: Luís Alberto O
authors.initials: LA
authors.lastname: Dallan
authors.forename: Luiz Antônio M
authors.initials: LA
authors.lastname: César
authors.forename: José Eduardo
authors.initials: JE
authors.lastname: Krieger
authors.forename: José Antônio F
authors.initials: JA
authors.lastname: Ramires
authors.forename: Sérgio A de
authors.initials: SA
authors.lastname: Oliveira
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000628:therapy*; D016026:Bone Marrow Transplantation; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009204:Myocardial Revascularization / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000628:therapy*