title: Current status of genetic modification of T cells for cancer treatment.
abstract: Clinical studies of adoptive immunotherapy with T cells have shown activity directed at hematologic and solid malignancies and viral infections. Genetic modification of infused T cells offers the prospect of improving such therapies and has already been used to track infused T cells, insert suicide genes and redirect the immune response towards specific Ag. Pre-clinical studies are evaluating novel approaches to genetically modify T cells to confer resistance to tumor evasion mechanisms. There is also increasing interest in developing suicide gene strategies as a failsafe mechanism to eradicate genetically modified cells should adverse effects occur.
authors.forename: G
authors.initials: G
authors.lastname: Dotti
authors.forename: H E
authors.initials: HE
authors.lastname: Heslop
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D018014:Gene Transfer Techniques; D041722:Genes, Transgenic, Suicide; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism / Q000637:transplantation
chemical_list: D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins