[The effect of hypoxen on the stress-induced ulcerogenesis in rats].
Immobilization stress induced ulcerous damage in the stomach mucosa of test rats. Prophylactic treatment with hypoxen in a daily dose of 50 mg/kg over a 5-day period decreased the number of ulcers and the total area of erosive injury in the mucous membrane, decreased the lipid peroxidation rate, and reduced the involution of thymus gland. This drug action can be classified as gastroprotective.
Novikov
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Losenkova
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Novikov
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D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000473:pathology; D007103:Immobilization; D008297:Male; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D000975:Antioxidants; D010647:Phenyl Ethers; C085806:olifen