A role of SAND-family proteins in endocytosis.
Caenorhabditis elegans has recently been used as an attractive model system to gain insight into mechanisms of endocytosis in multicellular organisms. A combination of forward and reverse genetics has identified a number of new membrane trafficking factors. Most of them have mammalian homologues which function in the same transport events. We describe a novel C. elegans gene sand-1, whose loss of function causes profound endocytic defects in many tissues. SAND-1 belongs to a conserved family of proteins present in all eukaryotic species, whose genome is sequenced. However, SAND family has not been previously characterized in metazoa. Our comparison of C. elegans SAND-1 and its yeast homologue, Mon1p, showed a conserved role of the SAND-family proteins in late steps of endocytic transport.
Poteryaev
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Friedrich Miescher Laboratory of the Max Planck Society, Spemannstrasse 39, Tuebingen D-72076, Germany. dmitry.poteryaev@tuebingen.mpg.de
Spang
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D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000494:pharmacology* / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; C506114:SAND-1 protein, C elegans