title: Prediction of prognosis in the UM-X7.1 hamster model of congestive heart failure using the Tei index.
abstract: BACKGROUND
  Cardiac function is difficult to evaluate in small animal models of heart disease. The Doppler Tei index is a simple and non-invasive measure that can express global cardiac function even in small animal models of congestive heart failure. However, its ability to predict prognosis has not been evaluated.
  
  
  RESULTS
  We tested the hypothesis that cardiac functional indices, such as the Tei index, can predict the prognosis of hamsters with cardiac dysfunction. The Tei index, defined as the sum of the isovolume contraction and relaxation time divided by ejection time, and the percent fractional shortening of the left ventricle was measured in 48 anesthetized male hamsters (19.7+/-0.4 weeks old) with cardiac dysfunction (UM-X7.1), using Doppler and 2-dimensional echocardiography. The hamsters were separated into 2 groups based on the median Tei index (0.50) and % fractional shortening (FS) (21%). Kaplan-Meier analysis determined the survival rates of the groups. Both the Tei index and %FS enabled significant distinction of better and poorer survival (p < 0.01), and the survival curves were less overlapped when the animals were separated according to the Tei index.
  
  
  CONCLUSIONS
  The Tei index can predict prognosis in a small animal model of heart failure.
authors.affiliation: Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Otsuji
authors.forename: Shiro
authors.initials: S
authors.lastname: Yoshifuku
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kamogawa
authors.forename: Toshinori
authors.initials: T
authors.lastname: Yuasa
authors.forename: Eiji
authors.initials: E
authors.lastname: Kuwahara
authors.forename: Kunitsugu
authors.initials: K
authors.lastname: Takasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uemura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakashiki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Miyata
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hamasaki
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Biro
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minagoe
authors.forename: Chuwa
authors.initials: C
authors.lastname: Tei
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D015150:Echocardiography, Doppler / Q000379:methods; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction; D011379:Prognosis