title: Pre-procedural ACE-activity does not predict symptomatic in-stent restenosis.
abstract: BACKGROUND
  Several studies indicate that ACE-activity is related to atherosclerosis. We investigated the correlation between ACE-activity, in plasma as well as in the atherosclerotic plaque, and in-stent restenosis.
  
  
  RESULTS
  ACE-activity was measured in blood samples from 178 patients who underwent a percutaneous coronary intervention with stent placement. During 8 months follow-up, 51 of these patients had an adverse clinical event. ACE-activity did not differ between patients with or without adverse events (21.5 vs. 23.1 nM/ml/min; P=0.36). Tissue samples were obtained with an atherectomy catheter before elective stent placement in another group of 13 patients with de novo stenosis. In this tissue, we determined the ACE-content immunohistologically. These patients were scheduled for follow-up quantitative coronary angiography after 12 months. In this group, the quantity of ACE was not correlated to the late luminal loss (0.31 vs. 0.38 mm; P=0.76).
  
  
  CONCLUSIONS
  In this study, pre-procedural ACE-activity, in plasma as well as in the atherosclerotic plaque, does not predict the occurrence of in-stent restenosis.
authors.affiliation: Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: Wagenaar
authors.forename: B M
authors.initials: BM
authors.lastname: Rahel
authors.forename: A J
authors.initials: AJ
authors.lastname: van Boven
authors.forename: A A
authors.initials: AA
authors.lastname: Voors
authors.forename: A C
authors.initials: AC
authors.lastname: van der Wal
authors.forename: H W M
authors.initials: HW
authors.lastname: Plokker
authors.forename: W H
authors.initials: WH
authors.lastname: van Gilst
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D017225:Atherectomy, Coronary; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D023903:Coronary Restenosis / Q000201:enzymology* / Q000601:surgery; D023921:Coronary Stenosis / Q000201:enzymology / Q000628:therapy*; D003331:Coronary Vessels / Q000201:enzymology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011379:Prognosis; D011475:Prosthesis Failure; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015607:Stents; D013997:Time Factors
chemical_list: D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A