Techniques of SNP genotyping and remote sensing applied for elucidation of the contribution of polygene and environmental factors to inter-individual variation in skin pigmentation phenotype.
We present a conceptual framework for applying techniques of SNP genotyping as a molecular biological approach and remote sensing as an ecological approach to elucidation of the contribution of polygene and environmental factors to inter-individual variation in skin pigmentation phenotype. Additionally, we discuss the obstacles that frustrate our efforts to identify how the human genome encodes the complex phenotype and suggest the use of computational methods designed for knowledge discovery within hereditary database.
Anno
Sumiko
S
Department of Engineering, Shibaura Institute of Technology, Tokyo, Japan. annou@sic.shibaura-it.ac.jp
Kudo
Susumu
S
Hamasaki
Keita
K
Matsumura
Kazunari
K
Yamamoto
Takushi
T
Ogata
Koretsugu
K
D001272:Atmosphere / Q000032:analysis; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D004777:Environment; D014644:Genetic Variation; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012880:Skin Pigmentation / Q000235:genetics*; D013053:Spectrophotometry / Q000379:methods; D013686:Telemetry / Q000379:methods