[The influence of the exogenous melanin on the development of the second generation of the female Wistar rats exposed during the critical period of the pegnancy at the nonsterilizing doses of different rate means].
The purpose of this study was to estimate the radio-protective activity of melanin for the reproductive status of Wistar rats. Wistar rats were exposed in utero either to the single gamma-irradiation on the tenth day of embryogenesis with the dose of 1 Gy or to the chronic gamma-irradiation with the total dose of 1 Gy during the first 10 days of embryogenesis. Such things like the ability of the rats to conceive, the embryogeny and early postnatal ontogeny of rat's posterity were studied. These doses of the radiation and the melanin did not produce the significant damages of the reproductive function of the survival offsprings of the first generation. The possible mechanisms of radio-protective effect of melanin on reproductive system of animals which have been exposed with the nonsterilizing doses at different mean dose rate were discussed.
Palyga
G F
GF
Zhavorokov
L P
LP
Chibisova
O F
OF
Pavlova
L N
LN
Ivanov
V L
VL
Kolganova
O I
OI
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D047108:Embryonic Development / Q000187:drug effects* / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D008297:Male; D018811:Maternal Exposure; D008543:Melanins / Q000494:pharmacology*; D011247:Pregnancy; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008543:Melanins; D011837:Radiation-Protective Agents