Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms.
Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/(on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.
DeGiorgio
C
C
UCLA-Geffen School of Medicine, Los Angeles, CA, USA. cmd@mednet.ucla.edu
Heck
C
C
Bunch
S
S
Britton
J
J
Green
P
P
Lancman
M
M
Murphy
J
J
Olejniczak
P
P
Shih
J
J
Arrambide
S
S
Soss
J
J
D003371:Cough / Q000209:etiology; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods* / Q000639:trends; D004566:Electrodes; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D010612:Pharyngitis / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome; D014630:Vagus Nerve / Q000502:physiology* / Q000601:surgery; D014832:Voice Disorders / Q000209:etiology