Pre-procedural ACE-activity does not predict symptomatic in-stent restenosis.
BACKGROUND
Several studies indicate that ACE-activity is related to atherosclerosis. We investigated the correlation between ACE-activity, in plasma as well as in the atherosclerotic plaque, and in-stent restenosis.


RESULTS
ACE-activity was measured in blood samples from 178 patients who underwent a percutaneous coronary intervention with stent placement. During 8 months follow-up, 51 of these patients had an adverse clinical event. ACE-activity did not differ between patients with or without adverse events (21.5 vs. 23.1 nM/ml/min; P=0.36). Tissue samples were obtained with an atherectomy catheter before elective stent placement in another group of 13 patients with de novo stenosis. In this tissue, we determined the ACE-content immunohistologically. These patients were scheduled for follow-up quantitative coronary angiography after 12 months. In this group, the quantity of ACE was not correlated to the late luminal loss (0.31 vs. 0.38 mm; P=0.76).


CONCLUSIONS
In this study, pre-procedural ACE-activity, in plasma as well as in the atherosclerotic plaque, does not predict the occurrence of in-stent restenosis.
Wagenaar
L J
LJ
Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands.
Rahel
B M
BM
van Boven
A J
AJ
Voors
A A
AA
van der Wal
A C
AC
Plokker
H W M
HW
van Gilst
W H
WH
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D017225:Atherectomy, Coronary; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D023903:Coronary Restenosis / Q000201:enzymology* / Q000601:surgery; D023921:Coronary Stenosis / Q000201:enzymology / Q000628:therapy*; D003331:Coronary Vessels / Q000201:enzymology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011379:Prognosis; D011475:Prosthesis Failure; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015607:Stents; D013997:Time Factors
D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A