High-density doxorubicin-conjugated polymeric nanoparticles via ring-opening metathesis polymerization.
High-density doxorubicin-conjugated polymeric nanoparticles are prepared via ring-opening metathesis polymerization and sustained release of nearly 50% of the anticancer agent is observed after 24 h in mildly acidic aqueous solution.
Bertin
Paul A
PA
Department of Chemistry and Center for Nanofabrication and Molecular Self-Assembly, Northwestern University, Evanston, IL 60208-3113, USA.
Smith
DeeDee
D
Nguyen
SonBinh T
ST
D004317:Doxorubicin / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*; D012996:Solutions
D011108:Polymers; D012996:Solutions; D004317:Doxorubicin