Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol.
The cationic complexes (1,2-diaminoethane)(maltolato)platinum(II) ([Pt(en)(ma)]+) and (1R,2R-1,2-diaminocyclohexane)(maltolato)platinum(II) ([Pt(R,R-DACH)(ma)]+) have been prepared and the structure of [Pt(R,R-DACH)(ma)]NO3 has been determined by single crystal X-ray diffraction. The geometry of the metal in [Pt(R,R-DACH)(ma)]NO3 is essentially square planar and the maltolate ligand has a geometry similar to other chelate complexes involving this ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and the IC50 values are approximately 32 microM in HeLa cells and 26 microM in K562 cells. In these cell lines the cytotoxicity of cisplatin is higher than the maltolate complexes by a factor of 2 to 3 whereas the cytotoxicity of carboplatin is lower than the maltolate complexes.
Carland
Michael
M
School of Chemistry, The University of Melbourne, Melbourne, Vic. 3010, Australia.
Tan
Kristine J
KJ
White
Jonathan M
JM
Stephenson
Jodie
J
Murray
Vincent
V
Denny
William A
WA
McFadyen
W David
WD
D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D003959:Diamines / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011753:Pyrones / Q000737:chemistry*
D003959:Diamines; D017671:Platinum Compounds; D011753:Pyrones; C008316:maltol