Sulfotransferase1A1 and risk of postmenopausal breast cancer.
The detoxification enzyme sulfotransferase1A1 (SULT1A1) is implicated in the inactivation of estrogens and the activation of promutagens and procarcinogens. SULT1A1 activity varies among individuals, and this difference in phenotype is, in part, controlled by genetic polymorphism (Arg-->His in codon 213). It is hypothesized that the His allele contributes to the risk of postmenopausal breast cancer. Frequencies of the Arg/His alleles were estimated in 229 postmenopausal breast cancer patients and 227 age-matched controls using a PCR-RFLP assay. Allele frequencies and genotype distributions were not statistically different between postmenopausal breast cancer patients and the population-based controls, i.e. neither of the alleles is associated with an increased risk of breast cancer in the present study.
Jerevall
Piiha-Lotta
PL
Department of Biomedicine and Surgery, Division of Cellbiology, Faculty of Health Sciences, University Hospital, S-581 85 Linköping, Sweden.
Ahmadi
Ahmad
A
Bergman
Malin
M
Stål
Olle
O
Wingren
Sten
S
D000368:Aged; D000483:Alleles; D015239:Arylsulfotransferase / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics* / Q000378:metabolism
D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human