Decrease of serotonin transporters in blood platelets after epileptic seizures.
Serotonin transporter (SERT) was studied by [3H]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average KD and BMax were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.
Cupello
Aroldo
A
Istituto di Bioimmagini e Fisiologia Molecolare, CNR, Sezione di Genova, Italy. dcupel@neurologia.unige.it
Favale
Emilio
E
Audenino
Daniela
D
Scarrone
Simona
S
Gastaldi
Stefania
S
Albano
Claudio
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D004830:Epilepsy, Tonic-Clonic / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D026901:Membrane Transport Proteins / Q000097:blood*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D017374:Paroxetine / Q000097:blood / Q000493:pharmacokinetics; D012640:Seizures / Q000378:metabolism*; D012701:Serotonin / Q000097:blood; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors / Q000097:blood / Q000493:pharmacokinetics
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017374:Paroxetine; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; C493230:SLC6A4 protein, human