title: Plasma ropivacaine levels during awake intracranial surgery.
abstract: Plasma ropivacaine levels produced by routine scalp infiltration for field block were assayed in eight patients undergoing awake intracranial surgery. Levels peaked within approximately 13 minutes, indicating rapid systemic absorption of ropivacaine. Potentially toxic plasma drug levels were achieved in three of eight patients, although no untoward effects attributable to elevated levels of ropivacaine were observed. Clinical vigilance is indicated during scalp infiltration with ropivacaine.
authors.affiliation: Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. paul.audu@jefferson.edu
authors.forename: Paul B
authors.initials: PB
authors.lastname: Audu
authors.forename: Chuck
authors.initials: C
authors.lastname: Wilkerson
authors.forename: Richard
authors.initials: R
authors.lastname: Bartkowski
authors.forename: Kevin
authors.initials: K
authors.lastname: Gingrich
authors.forename: Eugene
authors.initials: E
authors.lastname: Viscusi
authors.forename: David
authors.initials: D
authors.lastname: Andrews
mesh_terms: D000328:Adult; D000368:Aged; D000577:Amides / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010865:Pilot Projects; D000077212:Ropivacaine; D012535:Scalp; D014851:Wakefulness
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine