title: Antihypertensive treatment and new-onset diabetes mellitus.
abstract: The various antihypertensive regimens have varying effects on glucose metabolism and the development of diabetes mellitus. Recent large hypertension trials have shown great differences in the development of new-onset diabetes among antihypertensive drug therapies. The incidence of diabetes is unchanged or increased by thiazide diuretics and b-adrenergic blockers, and unchanged or decreased by angiotensin-converting enzyme inhibitors, calcium channel blockers, and angiotensin-receptor blockers. The differences in new-onset diabetes mellitus have not influenced the outcome of cardiovascular mortality and morbidity in all of the large clinical trials, but drug-induced diabetes among hypertensive patients is known to carry the same cardiovascular risk as that seen in patients with previously known diabetes; however, it might take years for the increased risk to become apparent.
authors.affiliation: Clinica Medica, Ospedale S Gerardo, University of Milan-Bicocca, Via Donizetti 106, 200 52 Monza, Italy. giuseppe.mancia@unimib.it.
authors.forename: Tonje Amb
authors.initials: TA
authors.lastname: Aksnes
authors.forename: Henrik M
authors.initials: HM
authors.lastname: Reims
authors.forename: Sverre E
authors.initials: SE
authors.lastname: Kjeldsen
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mancia
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects / Q000145:classification / Q000378:metabolism* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011236:Prediabetic State / Q000097:blood / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose