title: Wound care with antibacterial honey (Medihoney) in pediatric hematology-oncology.
abstract: The physiologic process of wound healing is impaired and prolonged in pediatric patients receiving chemotherapy. Due to profound immunosuppression, wound infection can easily spread and act as the source of sepsis. Referring to in vitro studies, which confirmed the antibacterial potency of special honey preparations against typical isolates of nosocomially acquired wound infections (including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant enterococci) and considering the encouraging reports from other groups, Medihoney has now been used in wound care at the Department of Pediatric Oncology, Children's Hospital, University of Bonn for 3 years. Supplemented with clinical data from pediatric oncology patients, this article reviews the scientific background and our promising experience with Medihoney in wound care issues at our institution. To collect and analyze the available experience, we prepare an internet-based data documentation module for pediatric wound care with Medihoney.
authors.affiliation: Department of Pediatric Hematology and Oncology, Children's Hospital, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany. asimon@ukb.uni-bonn.de
authors.forename: Arne
authors.initials: A
authors.lastname: Simon
authors.forename: Kai
authors.initials: K
authors.lastname: Sofka
authors.forename: Gertrud
authors.initials: G
authors.lastname: Wiszniewsky
authors.forename: Gisela
authors.initials: G
authors.lastname: Blaser
authors.forename: Udo
authors.initials: U
authors.lastname: Bode
authors.forename: Gudrun
authors.initials: G
authors.lastname: Fleischhack
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000276:immunology; D006722:Honey; D006801:Humans; D016867:Immunocompromised Host; D016106:Methicillin Resistance / Q000187:drug effects; D020713:Vancomycin Resistance / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents