title: Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia.
abstract: Schizophrenia has a complex and non-Mendelian mode of inheritance. Recently, trinucleotide repeat (TNR)-containing genes have been considered as the candidate genes predisposing to schizophrenia. The purpose of this study was to determine whether a genetic association could be observed between schizophrenia and the TNR polymorphisms within the KLHL1AS/SCA8, PPP2R2B/SCA12, and TBP/SCA17 genes. We studied 100 unrelated schizophrenia patients and 124 controls without evident neurodegenerative or psychiatric disorders. The overall allele frequency distributions of the KLHL1AS/SCA8 and PPP2R2B/SCA12 genes were not significantly different between the schizophrenic patients and the control subjects (P>0.05). The allele frequency distribution in the schizophrenic patients was significantly different from that in the controls at the TBP/SCA17 gene (P=0.0149), with an increased frequency of 36 repeats in the patients and two patients carrying 45 TNR expansions were identified. TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27. The study suggests that TNR expansions of the TBP/SCA17 gene may contribute to the genetic risk of schizophrenia in rare cases.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei 105, Taiwan.
authors.forename: Chiung-Mei
authors.initials: CM
authors.lastname: Chen
authors.forename: Hsien-Yuan
authors.initials: HY
authors.lastname: Lane
authors.forename: Yih-Ru
authors.initials: YR
authors.lastname: Wu
authors.forename: Long-Sun
authors.initials: LS
authors.lastname: Ro
authors.forename: Fen-Lin
authors.initials: FL
authors.lastname: Chen
authors.forename: Wei-Ling
authors.initials: WL
authors.lastname: Hung
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Hou
authors.forename: Cheng-Yueh
authors.initials: CY
authors.lastname: Lin
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Huang
authors.forename: I-Cheng
authors.initials: IC
authors.lastname: Chen
authors.forename: Bing-Wen
authors.initials: BW
authors.lastname: Soong
authors.forename: Ming-Liang
authors.initials: ML
authors.lastname: Li
authors.forename: Hsiu-Mei
authors.initials: HM
authors.lastname: Hsieh-Li
authors.forename: Ming-Tsan
authors.initials: MT
authors.lastname: Su
authors.forename: Guey-Jen
authors.initials: GJ
authors.lastname: Lee-Chen
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics; D010749:Phosphoprotein Phosphatases / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D054648:Protein Phosphatase 2; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012559:Schizophrenia / Q000235:genetics*; D035381:TATA-Binding Protein Associated Factors / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
chemical_list: C415906:ATXN8OS gene product, human; D009419:Nerve Tissue Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D035381:TATA-Binding Protein Associated Factors; C505936:PPP2R2B protein, human; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2