title: Allergenicity of a whey hypoallergenic formula in genetically at risk babies: four case reports.
abstract: BACKGROUND
  Hydrolysate formulas (HF) have been developed with the goal of reducing the allergenicity of cow's milk (CM) proteins, thus providing a suitable formula for feeding babies with CM allergy (CMA).
  
  
  OBJECTIVE
  More recently, whey HFs have provoked 208 reactions in babies at high risk of atopy when given for CMA prevention.
  
  
  METHODS
  We report the clinical and immunologic findings of four babies apparentlly sensitized by a partially whey hydrolysate formula (PWHF) in the nursery. They were exclusively BM (breast milk)-fed by their mothers avoiding highly allergenic foods, but experienced anaphylaxis after a re-feeding with the PWHF.
  
  
  RESULTS
  Sensitization to PWHF seems to have occurred in the first days of life. No baby suffered from allergic symptoms during BM-feeding.
  
  
  CONCLUSIONS
  These case reports suggest that a PWHF may be allergenic not only in an already sensitized subject, but also sensitizing in a genetically predisposed baby being immunogenic in the IgE system. These data strongly indicate that maternal diets during BM-feeding, in two instances suggested by family doctors, are effective as a BM complement.
authors.affiliation: Department of Pediatrics, Allergy and Clinical Immunology Division, University of Rome La Sapienza, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cantani
authors.forename: M
authors.initials: M
authors.lastname: Micera
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D041943:Infant Formula; D008297:Male; D016269:Milk Hypersensitivity / Q000517:prevention & control*; D008894:Milk Proteins / Q000276:immunology*; D011492:Protein Hydrolysates / Q000276:immunology*; D000067816:Whey Proteins
chemical_list: D008894:Milk Proteins; D011492:Protein Hydrolysates; D000067816:Whey Proteins