[Modulating effect of amino acids on cerebella of rats of various age in organotypic tissue culture].
There was studied in cerebella organotypic tissue culture the effect of effective concentrations (0.05 ng/ml) of 20 amino acids on the development of of proliferative activity in peripheral fields of explants of rats of various age: 3 days and 18 months old. The amino acids glycine, asparagine, lysine, arginine, proline, glutamine acid, cysteine, valine and isoleucine acid are active, inducing a more intensive growth zone in explants in 3-day old rats, as compared to control. The inhibitory effect was not observed. In the cerebella explant of old rats there was observed the inhibitory effect of 7 amino acids due to the apoptosis. This effect might be take in account by the synthesis of bioregulator peptides, contained these amino acids.
Komashnia
A V
AV
Chalisova
N I
NI
Pennijainen
V A
VA
Aniskina
A I
AI
Konovalova
Iu V
IuV
D000367:Age Factors; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis; D002531:Cerebellum / Q000187:drug effects* / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids