Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents.
A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.
Kidwai
Mazaahir
M
Department of Chemistry, University of Delhi, Delhi 110007, India. kidwai_chemistry@yahoo.co.uk
Saxena
Shilpi
S
Khan
M Khalilur Rahman
MK
Thukral
Sharanjit S
SS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002254:Carbonates; D004787:Environmental Pollution / Q000517:prevention & control; D004926:Escherichia coli / Q000187:drug effects; D008872:Microwaves; D011188:Potassium; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012996:Solutions; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014867:Water
D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D002254:Carbonates; D012996:Solutions; D014867:Water; C037593:potassium carbonate; D011188:Potassium