title: Increased proportion of high-affinity dopamine D2 receptors in rats with excitotoxic damage of the entorhinal cortex, an animal model of schizophrenia.
abstract: Excitotoxic lesions of the left entorhinal cortex (EC) cause dopamine supersensitivity. In order to determine if these lesions selectively alter the high-affinity state of dopamine D2 receptors (D2(High)), these high-affinity states were measured by competition between dopamine and [3H]domperidone in striata from lesioned rats and sham-operated animals. The proportion of D2(High) sites was significantly elevated by 200% in the EC-lesioned rats while that of the D1(High) sites, measured by dopamine/[3H]SCH23390 competition, was unaltered. These results provide a biochemical basis for behavioral supersensitivity in rats with EC lesions.
authors.affiliation: Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University School of Medicine, 2630 Sugitani, Toyama 930-0194, Japan. sumiyo@ms.toyama-mpu.ac.jp
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Philip
authors.initials: P
authors.lastname: Seeman
authors.forename: Takashi
authors.initials: T
authors.lastname: Uehara
authors.forename: Hiroko
authors.initials: H
authors.lastname: Itoh
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsunoda
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000378:metabolism; D018728:Entorhinal Cortex / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D007839:Functional Laterality; D008297:Male; D008694:Methamphetamine / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology*
chemical_list: D001552:Benzazepines; D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D008694:Methamphetamine