title: The relationship between serum resistin, leptin, adiponectin, ghrelin levels and bone mineral density in middle-aged men.
abstract: OBJECTIVE
  Body weight is a significant predictor of bone mass. Hormonal factors such as sex hormones, insulin, leptin and adiponectin are thought to play a role in the mechanisms controlling the association of body weight and fat mass with bone mass. However, contradictory results have been reported for the association between serum adipocytokines and bone mineral density (BMD). We therefore examined whether the serum adipocytokine and ghrelin levels, markers of fat metabolism, are associated with BMD in male adults.
  
  
  METHODS
  For 80 male adults (average age 54.5 +/- 6.4 years; average body mass index (BMI) 24.4 +/- 2.5 kg/m2), the correlations between serum resistin, leptin, adiponectin and ghrelin levels with BMD were investigated.
  
  
  RESULTS
  Among the adipocytokines, serum resistin levels were negatively correlated with lumbar spine BMD (r = -0.237, P = 0.05). After adjustment was made for age and BMI, log-transformed serum leptin showed a significant negative correlation with lumbar spine BMD, which was not seen on bivariate analysis (r = -0.237, P = 0.039). Femoral neck BMD was marginally associated only with serum adiponectin levels (r = -0.226, P = 0.062). In multiple regression analyses, among the adipokines, only resistin was a significant determinant of lumbar spine BMD, although the variance was small (R2 = 0.256). Serum ghrelin levels were not correlated with the BMD of either body site.
  
  
  CONCLUSIONS
  Serum resistin level showed a significant negative correlation with lumbar spine BMD, although the variance was small. Further studies are needed to elucidate the role of adipocytokines in bone metabolism.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Sacred Heart Hospital, Hallym University, Pyungchon-dong, Dongan-gu, Anyang-city, Kyungki-do, Chunchon, Korea. okwendo@yahoo.co.kr
authors.forename: Ki Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Won Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Baek
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Yoon
authors.forename: Moo Il
authors.initials: MI
authors.lastname: Kang
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Yun
authors.forename: Cheol Young
authors.initials: CY
authors.lastname: Park
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Ihm
authors.forename: Moon Gi
authors.initials: MG
authors.lastname: Choi
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Yoo
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Park
mesh_terms: D052242:Adiponectin; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000097:blood; D005272:Femur Neck; D054439:Ghrelin; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D052243:Resistin; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D036361:Peptide Hormones; C499624:RETN protein, human; D052243:Resistin; D014280:Triglycerides; D004958:Estradiol; D002784:Cholesterol