title: Two cyclopeptides from the seeds of Annona cherimola.
abstract: Bioassay-guided fractionation of cytotoxic of methanol extract of the seeds of Annona cherimola provided two novel cyclic peptides, cherimolacyclopeptide E (1) and cherimolacyclopeptide F (2), which exhibited significant cytotoxic activity against the KB (human nasopharyngeal carcinoma) cell culture system. The peptide 1 and 2 were elucidated by MS/MS fragmentation experiments using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR analyses and chemical degradation.
authors.affiliation: Laboratoire de Chimie Organique et Thérapeutique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop Dakar-Fann, Sénégal. alassanewele@yahoo.fr
authors.forename: Alassane
authors.initials: A
authors.lastname: Wélé
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Brouard
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pousset
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
mesh_terms: D000595:Amino Acid Sequence; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C506420:cherimolacyclopeptide E; C506421:cherimolacyclopeptide F