Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs.
The identification of novel biochemical components of the renin-angiotensin system (RAS) has added a further layer of complexity to the classical concept of this cardiovascular regulatory system. It is now clear that there is a counter-regulatory arm within the RAS that is mainly formed by the angiotensin-converting enzyme 2-angiotensin (1-7)-receptor Mas axis. The functions of this axis are often opposite to those attributed to the major component of the RAS, angiotensin II. This review will highlight the current knowledge concerning the cardiovascular effects of angiotensin-(1-7) through a direct interaction with its receptor Mas or through an indirect interplay with the kallikrein-kinin system. In addition, there will be a discussion of its role in the beneficial effects of angiotensin-converting enzyme inhibitors and angio-tensin receptor type 1 (AT1) antagonists, and the potential of this peptide and its receptor as a novel targets for new cardiovascular drugs.
Santos
Robson A S
RA
Departamento de Fisiologia e Biofísica, Avenue Antônio Carlos, 6627-ICB-UFMG, 31 270-901-Belo Horizonte, MG, Brazil.
Ferreira
Anderson J
AJ
Pinheiro
Sérgio V B
SV
Sampaio
Walkyria O
WO
Touyz
Rhian
R
Campagnole-Santos
Maria José
MJ
D000803:Angiotensin I / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D015507:Drugs, Investigational / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000378:metabolism*
D002316:Cardiotonic Agents; D015507:Drugs, Investigational; D010446:Peptide Fragments; D011945:Receptors, Angiotensin; D000803:Angiotensin I; C118790:angiotensin I (1-7)