title: Gene expression profiles in peripheral blood mononuclear cells from patients with subacute sclerosing panencephalitis using oligonucleotide microarrays.
abstract: To investigate the molecular basis for measles virus persistence in patients with subacute sclerosing panencephalitis (SSPE), the authors used a high-density oligonucleotide microarray, and found that the expression of granulysin in peripheral blood mononuclear cells was significantly lower in the patients than in the controls. By a quantitative reverse transcriptase-polymerase chain reaction, the mRNA levels of granulysin were decreased in 30 SSPE patients, and were increased in 7 measles patients, as compared to the 23 controls. These results imply that granulysin might play a role in the host defense against measles virus and possibly be involved in the pathogenesis or pathophysiology of SSPE.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. take-m@pediatr.med.kyushu-u.ac.jp
authors.forename: Megumi
authors.initials: M
authors.lastname: Takemoto
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kira
authors.forename: Koichi
authors.initials: K
authors.lastname: Kusuhara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Torisu
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Sakai
authors.forename: Toshiro
authors.initials: T
authors.lastname: Hara
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis / Q000235:genetics; D002648:Child; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007564:Japan; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D013344:Subacute Sclerosing Panencephalitis / Q000378:metabolism*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; C075005:GNLY protein, human; D012333:RNA, Messenger