Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism.
1. Strong etiological association exists between dysfunctional metabolism of brain lipids, age-related changes in the cerebral vasculature and neurodegenerative features characteristic of Alzheimer's disease (AD) brain. 2. In this short review, recent experimental evidence for these associations is further discussed below.
Lukiw
Walter J
WJ
LSU Neuroscience Center, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite 8D, New Orleans, Louisiana, 70112-2272, USA. wlukiw@lsuhsc.edu
Pappolla
Miguel
M
Pelaez
Ricardo Palacios
RP
Bazan
Nicolas G
NG
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001928:Brain Diseases, Metabolic / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D010084:Oxidation-Reduction
D008074:Lipoproteins; D002784:Cholesterol