Human soluble leptin receptor number in healthy normotensive individuals with high normal blood pressure.
BACKGROUND
High normal blood pressure (BP) seems to be related to increased cardiovascular risk in healthy normotensive subjects, whereas hyperleptinemia enhances both sympathetic tone and arterial BP. The aim of our study was to determine the human soluble leptin receptor number in healthy normotensive subjects with high normal BP and to compare these findings to those of healthy normotensive individuals with normal BP levels.


METHODS
We studied 36 healthy normotensive individuals with high normal BP (19 men and 17 women, mean age 42+/-8 years, body mass index [BMI] 23+/-1.5 kg/m2) and 40 healthy normotensive individuals with normal BP (23 men and 17 women, mean age 43+/-7 years, BMI 23.2+/-1.4 kg/m2). The two groups are matched for age, sex, and BMI. The human soluble leptin receptor number and immunoreactive leptin levels were determined in the study population by enzyme-linked immunoassay and radioimmunoassay, respectively.


RESULTS
Mean plasma leptin levels were significantly higher, whereas mean human soluble leptin receptor numbers were lower in the group with high normal BP compared with the normotensive group (10+/-4.8 v 6+/-2.7 ng/mL, P<.001 and 18+/-7 v 27+/-9 IU/mL, P<.001, respectively).


CONCLUSIONS
Our findings indicate that normotensive individuals with high normal BP have statistically significantly higher plasma leptin levels and lower numbers of human soluble leptin receptors. This observation may play a important role in the pathogenesis of cardiovascular events in this special group of patients and needs further investigation.
Papadopoulos
Dimitrios P
DP
Department of Cardiology, Laiko Hospital, and Laboratory of Experimental Surgery and Surgical Research, Athens Medical School, Athens, Greece. jimpapdoc@yahoo.com
Makris
Thomas K
TK
Krespi
Panagiota G
PG
Poulakou
Maria
M
Paizis
Ioannis A
IA
Hatzizacharias
Antonios N
AN
Perrea
Despina
D
Votteas
Vasilios V
VV
D000328:Adult; D000375:Aging / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000378:metabolism*; D054411:Receptors, Leptin; D012727:Sex Characteristics
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin