title: Treatment of verruca plantaris with a combination of topical fluorouracil and salicylic acid.
abstract: A medical record review was conducted to determine the clinical outcome and average time to resolution of verruca plantaris in 20 patients treated with twice-daily applications of either 0.5% or 5.0% topical fluorouracil combined with topical 17% and 40% salicylic acid. Seven patients used 0.5% fluorouracil, and 13 used 5.0% fluorouracil. All of the lesions were sharply debrided at regular 1- or 2-week intervals. All 20 patients achieved full clinical resolution in a mean +/- SD of 82.5 +/- 56.6 days. Three patients (15%) had recurrent lesions, which subsequently resolved with repeated treatment. Two patients (10%) developed local dermatitis, which resolved with temporary discontinuation of the medication and the addition of a topical corticosteroid. It was observed that the twice-daily application of topical fluorouracil and salicylic acid is a safe and effective treatment for verruca plantaris.
authors.affiliation: Podiatry Division, Department of Orthopedics, Cabrini Medical Center, New York, NY 10003, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Young
authors.forename: Greg E
authors.initials: GE
authors.lastname: Cohen
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000963:Antimetabolites / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D005534:Foot Diseases / Q000188:drug therapy*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014860:Warts / Q000188:drug therapy*
chemical_list: D000963:Antimetabolites; D007641:Keratolytic Agents; D020156:Salicylic Acid; D005472:Fluorouracil