title: Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee.
abstract: We describe a 21-year-old man with a large osteochondral defect of the knee after septic arthritis, successfully treated by transplant of mesenchymal stem cells (MSC) from bone marrow and a new type of interconnected porous hydroxyapatite ceramic (IP-CHA). We confirmed successful cartilage-like tissue regeneration by a second arthroscopy. Biopsy of the repaired tissue revealed cartilage-like regeneration and bone formation. We were able to regenerate new bone and cartilage-like tissue in a one-stage operation, without sacrificing autologous bone or other tissue. This cultured MSC and IP-CHA hybrid material transplant represents a novel treatment for a severe osteochondral defect after septic arthritis.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Japan. nadachi@hiroshima-u.ac.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Adachi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
authors.forename: Masataka
authors.initials: M
authors.lastname: Deie
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000328:Adult; D001170:Arthritis, Infectious / Q000473:pathology / Q000628:therapy*; D001706:Biopsy; D002356:Cartilage / Q000502:physiology; D002516:Ceramics / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D017886:Durapatite / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000166:cytology; D020370:Osteoarthritis, Knee / Q000473:pathology / Q000628:therapy*; D012038:Regeneration; D012720:Severity of Illness Index; D033581:Stem Cell Transplantation
chemical_list: D017886:Durapatite