title: Bioresorbable composites prepared by supercritical fluid foaming.
abstract: Bone is a natural composite construct, with a gradient structure going from a loose interconnected cellular core to an outer dense wall, thus minimizing bone weight while keeping a high mechanical resistance. Due to this unique and complex structure, bone defects are difficult to replace or repair. Tissue engineering aims at providing artificial bone grafts. Several techniques have been proposed to produce porous structures or scaffolds, but, as yet, with no optimal solutions. This article focuses on bioresorbable ceramic-polymer composite foams obtained by supercritical fluid foaming. This flexible technique enables an adequate morphology and suitable properties for bone tissue engineering to be obtained. Composite scaffolds are biocompatible, allowing cell proliferation and differentiation.
authors.affiliation: Laboratoire de Technologie des Composites et Polymères (LTC), Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
authors.forename: L M
authors.initials: LM
authors.lastname: Mathieu
authors.forename: M-O
authors.initials: MO
authors.lastname: Montjovent
authors.forename: P-E
authors.initials: PE
authors.lastname: Bourban
authors.forename: D P
authors.initials: DP
authors.lastname: Pioletti
authors.forename: J-A E
authors.initials: JA
authors.lastname: Månson
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000737:chemistry / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D017886:Durapatite / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry; D011312:Pressure; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D046911:Macromolecular Substances; D011108:Polymers; D012997:Solvents; D017886:Durapatite