title: Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome.
abstract: BACKGROUND
  The present study was designed to investigate the effects of polycystic ovary syndrome (PCOS) and of obesity on serum parathyroid hormone (RhoTauEta), 25-hydroxyvitamin D (25-OH-vitamin D), and 1,25-dihydroxyvitamin D [1,25-(OH)2-vitamin D] concentrations and the possible associations of the above calciotropic hormones with the hormonal and metabolic characteristics of the syndrome.
  
  
  METHODS
  We studied 58 obese [body mass index (BMI)>30 kg/m2] women with PCOS, 64 overweight (BMI, 25-30 kg/m2) women with the syndrome, 169 normal-weight (BMI<25 kg/m2) women with PCOS, 29 obese controls (ovulatory women without clinical or biochemical hyperandrogenemia), 14 overweight controls, and 70 normal-weight controls. Blood samples were collected (at 0900 after an overnight fast) between the 3rd and 6th days of a menstrual cycle in the control groups and during a spontaneous bleeding episode in the PCOS groups. Circulating concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone, Delta4-androstenedione, 17alpha-hydroxyprogesterone, sex-hormone-binding globulin (SHBG), insulin, glucose, PTH, 25-OH-vitamin D, and 1,25-(OH)2-vitamin D were measured.
  
  
  RESULTS
  Both PCOS and increased body weight had a significant positive effect on serum PTH values. PTH concentrations were significantly correlated with age, BMI, glucose, PRL, SHBG, and testosterone. Only the correlations with testosterone and PRL were BMI-independent. The effect of PCOS on PTH concentrations remained significant after adjustment for BMI, but not after adjustment for testosterone concentration. Increased body weight also had a significant negative effect on 25-OH- and 1,25-(OH)2-vitamin D concentrations, but no association with the syndrome was observed.
  
  
  CONCLUSIONS
  The results of the present study are in agreement with previous data supporting an association of increased PTH and decreased vitamin D metabolite concentrations with obesity. Moreover, the present findings indicate, for the first time, that PTH probably is also linked to PCOS-associated hyperandrogenism.
authors.affiliation: Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. argic@med.auth.gr
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Panidis
authors.forename: Christos
authors.initials: C
authors.lastname: Balaris
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Farmakiotis
authors.forename: David
authors.initials: D
authors.lastname: Rousso
authors.forename: Anargyros
authors.initials: A
authors.lastname: Kourtis
authors.forename: Vassilios
authors.initials: V
authors.lastname: Balaris
authors.forename: Ilias
authors.initials: I
authors.lastname: Katsikis
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Zournatzi
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diamanti-Kandarakis
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D