Postradiation malignant fibrous histiocytoma and osteosarcoma of a patient with high telomerase activities.
BACKGROUND
An extremely rare case of postradiation malignant fibrous histiocytoma (MFH) and osteosarcoma (OS) secondary to radiation therapy for leukemia-related osteolytic lesions is presented. In addition, the telomere biology of these tumors was investigated.


METHODS
A 14-year-old boy was diagnosed with acute lymphocytic leukemia. The right tibia was irradiated at a total dose of 60 Gy, and the left tibia was irradiated at a total dose of 40 Gy. The left tibia developed MFH and the right tibia developed OS.


RESULTS
Telomere reduction (MFH 70.2, OS 70.0%) and high telomerase activities (MFH 12.1, OS 17.7 TPG) were observed. These results reflect an aggressive feature of postradiation sarcomas.


CONCLUSIONS
Prognosis for patients diagnosed with postradiation sarcoma is poor due to its aggressiveness. However, even if sarcoma occurs after irradiation in more than two fields in a single patient, improvements in prognosis are anticipated with appropriate chemotherapies and wide resection.
Matsuo
Toshihiro
T
Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. tmatsuo@hiroshima-u.ac.jp
Sugita
Takashi
T
Shimose
Shoji
S
Kubo
Tadahiko
T
Yasunaga
Yuji
Y
Hiyama
Eiso
E
Ochi
Mitsuo
M
D000293:Adolescent; D001859:Bone Neoplasms / Q000201:enzymology* / Q000209:etiology; D018219:Histiocytoma, Benign Fibrous / Q000201:enzymology* / Q000209:etiology; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000201:enzymology* / Q000209:etiology; D010014:Osteolysis / Q000532:radiotherapy; D012516:Osteosarcoma / Q000201:enzymology* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000532:radiotherapy; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism; D013977:Tibia / Q000528:radiation effects
D019098:Telomerase