[The chromosome aberrations in human peripheral blood lymphocytes 43-46 years after the acute radiation disease].
Cytogenetic study of workers, who had an acute radiation syndrome of the medium (ARS II), severe (ARS III) and extremely severe (ARS III-IV) degrees in 1953-1957, was performed. Lymphocytes from peripheral blood were cultured and analyzed with using the routine chromosome staining (4 individuals) and FISH (2 individuals) methods. In each case 4000-1000 metaphase slides were analyzed with the group chromosome kariotyping. A high frequency of chromosome aberrations (CA) was revealed, i.e.: 9.33-9.8 CA per 100 cells for ARS II patients, 28.6 and 36.6 CA per 100 cells for patients with the severe ARS. The main type of rearrangement is stable CA (up to 90%). The CA frequency exceeds the level of spontaneous CA (control--20 individuals) and CA of the patients, who had Chronic Radiation Disease (CrRD) 45 years ago (20 individuals). By 43-46 years of the control. No cancer diseases or hematopoietic pathology were revealed by 43-46 years of follow-up.
Okladnikova
N D
ND
Pesternikova
V S
VS
D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects*; D020732:Cytogenetic Analysis; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000097:blood / Q000166:cytology; D008297:Male; D011832:Radiation Injuries / Q000175:diagnosis*; D018788:Radioactive Hazard Release; D013997:Time Factors