title: A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus.
abstract: Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.
authors.affiliation: Department of Molecular Biology, University of Aarhus, Denmark.
authors.forename: Sys Zoffmann
authors.initials: SZ
authors.lastname: Glud
authors.forename: Annette Balle
authors.initials: AB
authors.lastname: Sørensen
authors.forename: Mindaugas
authors.initials: M
authors.lastname: Andrulis
authors.forename: Bruce
authors.initials: B
authors.lastname: Wang
authors.forename: Eisaku
authors.initials: E
authors.lastname: Kondo
authors.forename: Randi
authors.initials: R
authors.lastname: Jessen
authors.forename: Laszlo
authors.initials: L
authors.lastname: Krenacs
authors.forename: Eva
authors.initials: E
authors.lastname: Stelkovics
authors.forename: Matthias
authors.initials: M
authors.lastname: Wabl
authors.forename: Edgar
authors.initials: E
authors.lastname: Serfling
authors.forename: Alois
authors.initials: A
authors.lastname: Palmetshofer
authors.forename: Finn Skou
authors.initials: FS
authors.lastname: Pedersen
mesh_terms: D000818:Animals; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000276:immunology*; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D050778:NFATC Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D012192:Retroviridae Infections / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000276:immunology*; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016662:Virus Integration / Q000276:immunology
chemical_list: D050778:NFATC Transcription Factors; C494009:Nfatc3 protein, mouse; D025521:Tumor Suppressor Proteins