title: Dietary unripe apple polyphenol inhibits the development of food allergies in murine models.
abstract: The incidence of type I allergic disorders has been increasing worldwide, particularly, the hypersensitivity to food. We first showed that apple condensed tannin (ACT) intake would inhibit the development of the oral sensitization and that the inhibition could correlate with the rise in the population of TCR(gamma)delta-T cells in the intestinal intraepithelial lymphocytes (IEL) using W/W(V) mice and B10A mice which were ovalbumin (OVA)-orally sensitized. Serum OVA-specific immunoglobulin E and immunoglobulin G1 titers in the OVA-orally sensitized W/W(V) and B10A mice ad libitium fed ACT were extremely inhibited compared to those of the control. The ACT intakes of OVA-sensitized W/W(V) and B10A mice inhibited the immediate reduction of the body temperature or the rise in serum histamine induced by active systemic anaphylaxis. The proportions of the TCR(gamma)delta-T cells in the IEL of the OVA-orally sensitized W/W(V) and B10A mice ad libitium fed ACT were significantly greater than that in the controls. Furthermore, ACT feeding by itself could induce the rise in the percentage of the TCR(gamma)delta-T cells among the IEL of the W/W(V) and B10A mice. This suggests that the ACT intake may prevent the development of food allergies and this effect could be correlated with the rise in the percentage of TCR(gamma)delta-T cells among the IEL.
authors.affiliation: National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku Tokyo 158-8501, Japan. akiyama@nihs.go.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akiyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sato
authors.forename: Takahiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Megumi H
authors.initials: MH
authors.lastname: Nagaoka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shoji
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Kanda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yamada
authors.forename: Mamoru
authors.initials: M
authors.lastname: Totsuka
authors.forename: Reiko
authors.initials: R
authors.lastname: Teshima
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Sawada
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
authors.forename: Tamio
authors.initials: T
authors.lastname: Maitani
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D001831:Body Temperature; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D005512:Food Hypersensitivity / Q000517:prevention & control*; D006632:Histamine / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D027845:Malus / Q000737:chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D010047:Ovalbumin / Q000276:immunology; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D059808:Polyphenols; D044945:Proanthocyanidins / Q000008:administration & dosage / Q000627:therapeutic use*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000485:Allergens; D005419:Flavonoids; D007074:Immunoglobulin G; D010636:Phenols; D059808:Polyphenols; D044945:Proanthocyanidins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D007073:Immunoglobulin E; D006632:Histamine; D010047:Ovalbumin