[Animal experimental study of the treatment of periapical disease with recombinant human bone morphogenetic protein-2 composite].
OBJECTIVE
To investigate the effect of the treatment of periapical diseases with recombinant human netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application.


METHODS
The endotoxin-bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical were built. The rhBMP-2 composite was mixed by rhBMP-2, TCP, collagen and metronidazole and used in the treatment cal diseases in dog models as root apex screen. The imageology and pathology research were went on.


RESULTS
The effective rate of the experimental group was remarkably higher than that of the carrier group and the control group with remarkable ference (P < 0.05). The quality of the repair of tissue was obviously better than the two other groups.


CONCLUSIONS
The rhBMP-2 composite is a promising biological root-canal filling material.
Peng
Huo-Guang
HG
Dept. of Dentistry, Affiliated Hospital of the Medical College, Hangzhou Teachers College, Hangzhou 310015, China.
Wang
Zhu-Ping
ZP
Liu
Ting-Yan
TY
Wang
Duo
D
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D003094:Collagen; D004285:Dogs; D006801:Humans; D010483:Periapical Diseases; D011994:Recombinant Proteins; D012387:Root Canal Filling Materials; D016212:Transforming Growth Factor beta
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D012387:Root Canal Filling Materials; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen