title: Dietary Garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake.
abstract: The influence of 3.3% Garcinia cambogia extract on the properties of mouse skin with or without 10% sucrose water loading was investigated. Mice (7-week-old) were given free access to a control diet or a diet containing Garcinia cambogia extract. They were also given water alone or both water and sucrose water. Their skin was compared by both biochemical and histological methods. The collagen and triacylglycerol contents were not significantly different among the four groups. Similarly, electron microscopy revealed no differences in the thickness of the dermis layer or the subcutaneous tissue layer. Mice given the diet containing Garcinia cambogia tended to have a reduced total number of adipocytes, but not significantly. These results suggest that Garcinia cambogia supplementation for at least 4 weeks does not induce a negative effect on skin properties in mice irrespective of excessive sucrose intake.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Oikawa
authors.forename: Hachidai
authors.initials: H
authors.lastname: Hirakawa
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Hayamizu
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Nobuya
authors.initials: N
authors.lastname: Shiba
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Hisao
authors.initials: H
authors.lastname: Iwamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tachibana
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D029761:Garcinia cambogia; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D004040:Dietary Carbohydrates; D010936:Plant Extracts; D014280:Triglycerides; D013395:Sucrose; D003094:Collagen