title: 'O-Acyl isopeptide method' for the efficient preparation of amyloid beta peptide 1-42 mutants.
abstract: Novel water-soluble isopeptides of Abeta1-42 mutants, '26-O-acyl isoAbeta1-42 (26-AIAbeta42) mutants', which were efficiently converted to intact Abeta1-42 mutants with no byproduct formation under physiological conditions, were synthesized. These isopeptides provide a new system useful for investigating the biological function of Abeta1-42 mutants.
authors.affiliation: Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Sohma
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Chiyomori
authors.forename: Maiko
authors.initials: M
authors.lastname: Kimura
authors.forename: Fukue
authors.initials: F
authors.lastname: Fukao
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tooru
authors.initials: T
authors.lastname: Kimura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiso
mesh_terms: D000215:Acylation; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis* / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000235:genetics; D012995:Solubility; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D014867:Water