title: Evolution of the NadR regulon in Enterobacteriaceae.
abstract: The NAD biosynthetic pathway and NAD transformations in E. coli and S. typhi are well characterized. Using comparative genomics methods we describe the NadR regulon in other Enterobacteriaceae, identity new candidate regulon members and demonstrate that even a very simple regulon covering an essential methabolic pathway could be different in closely related genomes.
authors.affiliation: Laboratory of Bioinformatics, State Scientific Center GOSNIIGenetika, 1-iy Dorozhny proezd 1, Moscow, 113545, Russia. a_gerasimova@yahoo.com
authors.forename: Anna V
authors.initials: AV
authors.lastname: Gerasimova
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Gelfand
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D004269:DNA, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D018085:Regulon / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*; D013045:Species Specificity
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C117105:NadR protein, bacteria; D012097:Repressor Proteins