[Relationship between the aldosterone synthase (CYP11B2)-344C/T polymorphism and small artery compliance].
OBJECTIVE
To investigate the relationship between the aldosterone synthase (CYP11B2)-344C/T polymorphism and small artery compliance (C(2)).


METHODS
C(2) was measured by CVProfilor DO-2020 in 224 subjects, including 123 subjects with an abnormal C(2) and 101 normal controls. Genotypes of CYP11B2 were determined by polymerase chain reaction-based restriction fragment length polymorphism analysis.


RESULTS
The frequencies of the CYP11B TT genotype and T allele in subjects with an abnormal C(2) were slightly higher than in normal controls, but the differences did not reach statistical significance (55.3% vs 41.6%, P > 0.05, 75.6% vs 66.8%, P > 0.05. However, when CT was combined with CC, the frequency of TT in subjects with an abnormal C(2) was significantly higher than in normal controls (P < 0.05). By CANOVA, TT subjects had a lower C(2) than CT and CC subjects (P < 0.05). Logistic regression analysis revealed that TT genotype was associated with abnormal C(2) (P = 0.043, OR = 1.93 95% CI 1.02-3.63).


CONCLUSIONS
The CYP11B-344C/T polymorphism is associated with small artery compliance, and TT subjects are susceptible to abnormality of small arterial compliance.
Li
Xin-li
XL
Department of Cardiology, The Fist Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. xinli3267@yeah.net
Liang
Li-rong
LR
Ni
Chun-hui
CH
Wang
Zhen-zhen
ZZ
Li
Ai-ping
AP
Liao
Jing
J
Zhou
Jian-wei
JW
Cao
Ke-jiang
KJ
Huang
Jun
J
D000328:Adult; D001160:Arterioles / Q000502:physiology*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D019405:Cytochrome P-450 CYP11B2