title: The molecular basis of neutral aminoacidurias.
abstract: Recent success in the molecular cloning and identification of apical neutral amino acid transporters has shed a new light on inherited neutral amino acidurias, such as Hartnup disorder and Iminoglycinuria. Hartnup disorder is caused by mutations in the neutral amino acid transporter B(0) AT1 (SLC6A19). The transporter is found in kidney and intestine, where it is involved in the resorption of all neutral amino acids. The molecular defect underlying Iminoglycinuria has not yet been identified. However, two transporters, the proton amino acid transporter PAT1 (SLC36A1) and the IMINO transporter (SLC6A20) appear to play key roles in the resorption of glycine and proline. A model is presented, involving all three transporters that can explain the phenotypic variability of iminoglycinuria.
authors.affiliation: School of Biochemistry and Molecular Biology, Australian National University, Canberra.
authors.forename: Angelika
authors.initials: A
authors.lastname: Bröer
authors.forename: Juleen A
authors.initials: JA
authors.lastname: Cavanaugh
authors.forename: John E J
authors.initials: JE
authors.lastname: Rasko
authors.forename: Stefan
authors.initials: S
authors.lastname: Bröer
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000235:genetics / Q000378:metabolism; D021542:Amino Acids, Neutral / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D000608:Renal Aminoacidurias / Q000378:metabolism*
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D021542:Amino Acids, Neutral