title: [Effect of E-selectin A561C (S128R) polymorphism on blood pressure].
abstract: OBJECTIVE
  To investigate the effect of E-selectin A561C (S128R) polymorphism on blood pressure.
  
  
  METHODS
  347 essential hypertensive patients (male 163 and female 184, age 46.08 +/- 12.49 y, and body mass index 26.13 +/- 3.14 kg/m(2)) and 315 normal controls (male 93 and female 222, age 42.21 +/- 14.67 y, and body mass index 25.66 +/- 3.19 kg/m(2)) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Phenotypic measurements included blood pressure, blood glucose, serum triglycerides, serum total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, serum uric acid, blood urea nitrogen, nitric oxide, endothelin, angiotensin I, and II and plasma aldosterone.
  
  
  RESULTS
  The frequencies of the AC and CC genotypes (6.92%) and C allele (4.76%) were significantly (P = 0.029 and 0.013) higher in hypertensive patients than normal controls (3.17% and 2.22%). The relative risk of hypertension associated with the C allele was 2.197 (95% CI: 1.164-4.144). Both diastolic blood pressure and mean arterial pressure were higher in C allele carriers than AA subjects (P = 0.049 and 0.024). Furthermore, C allele carriers, compared with AA subjects, had higher concentrations of blood glucose, and total and LDL cholesterol (P = 0.031, 0.046, and 0.003) and lower concentrations of nitric oxide (P = 0.036).
  
  
  CONCLUSIONS
  The E-selectin A561C (S128R) polymorphism might affect blood pressure in Chinese.
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
authors.forename: Hai-ling
authors.initials: HL
authors.lastname: Chen
authors.forename: Qi
authors.initials: Q
authors.lastname: Hua
authors.forename: Rong-kun
authors.initials: RK
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000328:Adult; D019040:E-Selectin / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D019040:E-Selectin