title: HIV type 1 strains common in Europe, Africa, and Asia cocirculate in Yemen.
abstract: To determine the HIV-1 genetic diversity in Yemen, 19 strains collected from men and women were sequenced in pol and six of those were full genome sequenced; all were phylogenetically analyzed. Using the pol sequence data, nine (47.3%) were subtype B, six (31.6%) subtype C, two (10.5%) subtype D, one strain (5.3%) subtype A, and another (5.3%) a unique recombinant form (URF). Concordant phylogenies were also obtained for the six strains full genome sequenced. Most of the strains were from the capitol, Sana'a (n=16). Five of the C strains clustered with African Cs, and one clustered with the Indian C strains. Of the two subtype D strains, one clustered with Ugandan strains and one with Cameroon. The subtype A strain was similar to a Cameroon variant of subtype A and the URF strain was a recombinant between CRF11, CRF13, and subtype B. The HIV epidemic in Yemen is extremely complex, with strains of HIV-1 that have originated in East and West Africa, Europe, and India.
authors.affiliation: United States Naval Medical Research Unit No. 3, Cairo, Egypt. DarwishM@namru3.org
authors.forename: Magdi D
authors.initials: MD
authors.lastname: Saad
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Jaufy
authors.forename: Robert R
authors.initials: RR
authors.lastname: Grahan
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nadai
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Earhart
authors.forename: Jose L
authors.initials: JL
authors.lastname: Sanchez
authors.forename: Jean K
authors.initials: JK
authors.lastname: Carr
mesh_terms: D000328:Adult; D000349:Africa; D001208:Asia; D005060:Europe; D005260:Female; D015684:Gene Products, pol / Q000235:genetics; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D010802:Phylogeny; D015006:Yemen
chemical_list: D015684:Gene Products, pol