title: Endoscopic submucosal dissection for early gastric cancer.
abstract: Endoscopic mucosal resection (EMR) has been accepted as a treatment of early gastric cancer (EGC). The number of EMR procedures for EGC has been increasing because a patient's quality of life after EMR is superior to that after surgical gastrectomy. In Japan, most EMR have been performed using the strip biopsy method; however, in some cases we experienced local recurrences when multiple fragments had been resected by this method. Single-fragment resection is preferable for correct histological diagnosis and a patient's prognosis. Recently, dramatic changes have occurred in the operational technique and design of the accessory apparatus. In 1996, we developed a special endoscopic knife, called the insulation-tipped electrosurgical knife (IT knife), which consists of a conventional diathermic needle knife with a ceramic ball at the top to minimize the risk of perforation. This knife can cut submucosa safely and remove a lesion completely. We named this method endoscopic submucosal dissection (ESD). Using this procedure, 96% of the tumors (471/488) were completely resected in one piece. During the follow-up period, there were no recurrent cases. One-piece resection by ESD using the IT knife improves the quality of life and prognosis for patients with early gastric cancer.
authors.affiliation: Endoscopy and GI Oncology Division, Shizuoka Cancer Center Hospital, Shizuoka, Japan. h.ono@scchr.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ono
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D013505:Digestive System Surgical Procedures; D004210:Dissection; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000601:surgery*