Intralesional fibrous septum in chordoma: a clinicopathologic and immunohistochemical study of 122 lesions.
Intralesional fibrous septum (IFS) generally is considered a reactive tissue in chordoma; however, little is known about its significance. We studied 122 chordomas for IFS using immunohistochemical techniques and compared IFS and lobular growth patterns (LGPs) formed by IFS with clinicopathologic parameters. Seventy-nine tumors (64.8%) revealed IFS. However, IFS frequently was infiltrated and interrupted by tumor cells with increased expression of proteases; only 33 (42%) of 79 tumors had LGP. In non-skull base chordomas, IFS and LGP were associated with nuclear pleomorphism, a previously described prognostic indicator, mitosis, and the MIB-1 labeling index, indicating a role of IFS and LGP in tumor growth or progression. Paradoxically, patients without LGP tended to have a worse prognosis than those with LGP. We believe that IFS exerts diverse influences on chordoma; however, invasion of IFS leading to loss of the LGP indicates advanced stages of tumor development, possibly predicting an unfavorable prognosis in chordoma.
Naka
Takahiko
T
Department of Pathology, Faculty of Medicine, Magdeburg University, Magdeburg, Germany.
Boltze
Carsten
C
Kuester
Doerthe
D
Samii
Amir
A
Herold
Christian
C
Ostertag
Helmut
H
Iwamoto
Yukihide
Y
Oda
Yoshinao
Y
Tsuneyoshi
Masazumi
M
Roessner
Albert
A
D001859:Bone Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D002817:Chordoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D005355:Fibrosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D011379:Prognosis
D019394:Ki-67 Antigen; D010447:Peptide Hydrolases