AAA+ proteins: have engine, will work.
The AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.
Hanson
Phyllis I
PI
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. phanson@cellbiology.wustl.edu
Whiteheart
Sidney W
SW
D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D017124:Conserved Sequence; D018360:Crystallography, X-Ray; D004261:DNA Replication; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D013379:Substrate Specificity
D000251:Adenosine Triphosphatases