Dietary approach to decrease aging-related CNS inflammation.
We demonstrate that the spontaneously hypertensive rat stroke-prone rat (SHRsp) undergoes premature aging of the CNS compared to the related normotensive Wistar Kyoto rat (WKY) as demonstrated by presence of activated microglia/macrophages, increased expression of inducible nitric oxide synthase and increased astrogliosis. We tested the hypothesis that dietary intake of phase 2 protein inducers would decrease these aging-associated degenerative changes. The source of dietary phase 2 protein inducers was dried broccoli sprouts of a cultivar containing high amounts of glucoraphanin that gives rise to phase 2 protein-inducing isothiocyanate sulforaphane. This diet significantly decreased the aging-related degenerative changes in the SHRsp CNS. We conclude that modest changes in diet may have profound effects on the aging CNS.
Noyan-Ashraf
M H
MH
Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
Sadeghinejad
Z
Z
Juurlink
B H J
BH
D000375:Aging; D000818:Animals; D001253:Astrocytes / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D015153:Blotting, Western; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D001937:Brassica / Q000737:chemistry; D002493:Central Nervous System Diseases / Q000473:pathology / Q000517:prevention & control*; D004032:Diet; D005947:Glucose / Q000008:administration & dosage / Q000031:analogs & derivatives; D005961:Glucosinolates; D007096:Imidoesters / Q000008:administration & dosage; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology / Q000517:prevention & control*; D008264:Macrophages / Q000737:chemistry; D017628:Microglia / Q000737:chemistry; D019001:Nitric Oxide Synthase / Q000032:analysis; D052247:Nitric Oxide Synthase Type II; D010091:Oximes; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013116:Spinal Cord / Q000737:chemistry / Q000473:pathology; D013454:Sulfoxides
D015415:Biomarkers; D005961:Glucosinolates; D007096:Imidoesters; D010091:Oximes; D013454:Sulfoxides; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D005947:Glucose; C119494:glucoraphanin