[The analysis of I125 brachytherapy complications in cases of uveal melanoma].
OBJECTIVE
Analysis of type and frequency of complications after brachytherapy 1125 between 1-12 months after treatment and during the following controls.


METHODS
147 persons (76 men and 71 women) aged 23-86 years (mean 57 years), were treated in our clinic in 1998-2001. In 43% of the cases the thickness of the tumor was more than 8 mm and in 94% the maximum diameter was bigger than 8.1 mm. The irradiation dose was 80-120 Gy, mean 100 Gy.


RESULTS
Regression and stabilization of the tumor was achieved in 84.3% of all cases. Complications of different type and intensity associated with brachytherapy I125 were observed in majority of the cases. The complications observed were: radiation retinopathy (52%), radiation maculopathy (33.6%), radiation optic neuropathy (25.3%), vitreous hemorrhage (8.8%), glaucoma (20.5%) and cataract (18.5%).


CONCLUSIONS
125I brachytherapy yields good results in cases of uveal melanoma, however it's associated with post radiation complications.
Pogrzebielski
Arkadiusz
A
Z Katedry i Kliniki Okulistyki Collegium Medicum Uniwersytetu Jagiellońiskiego w Krakowie.
Starzycka
Maria
M
Romanowska-Dixon
Bozena
B
Jakubowska
Barbara
B
Szpakowicz
Urszula
U
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D002386:Cataract / Q000209:etiology; D005260:Female; D005901:Glaucoma / Q000209:etiology; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000209:etiology; D011829:Radiation Dosage; D012164:Retinal Diseases / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000532:radiotherapy*; D014823:Vitreous Hemorrhage / Q000209:etiology
D007457:Iodine Radioisotopes