Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica.
Bioassay-directed fractionation of the EtOAc extract of Kadsura japonica has led to the isolation of six new C18 dibenzocyclooctadiene lignans, schizanrins I, J, K, L, M, N, along with four known C19 homolignans, taiwanschirins A, B, C, and heteroclitin F. The elucidations of the new structures were based on spectral analysis. Bioassay evaluation against human type B hepatitis revealed that taiwanschirins A and B showed strong activity for anti-HBsAg and a medium effect for anti-HBeAg at 25 microg/mL (12.9 and 11.9 microM for taiwanschirins A and B, respectively).
Kuo
Yao-Haur
YH
National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C.
Wu
Ming-Der
MD
Huang
Ray-Ling
RL
Kuo
Li-Ming Yang
LM
Hsu
Ya-Wen
YW
Liaw
Chia-Ching
CC
Hung
Chia-Cheng
CC
Shen
Ya-Ching
YC
Ong
Chi-Wi
CW
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D034242:Cyclooctanes / Q000737:chemistry / Q000494:pharmacology; D006509:Hepatitis B / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000187:drug effects*; D006513:Hepatitis B e Antigens / Q000187:drug effects*; D006801:Humans; D032135:Kadsura; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D034242:Cyclooctanes; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017705:Lignans; D010936:Plant Extracts