title: Abdominal adiposity assessed by dual energy X-ray absorptiometry provides a sex-independent predictor of insulin sensitivity in older adults.
abstract: BACKGROUND
  An increase in total adiposity and in particular an abdominal distribution of adiposity may contribute to the decline in metabolic insulin sensitivity observed in older men and women. The objective of this cross-sectional study was to determine which measure of abdominal adiposity would provide the best sex-independent predictor of metabolic insulin sensitivity in older men and women.
  
  
  METHODS
  Insulin sensitivity and abdominal adiposity were measured in healthy, nondiabetic older (64 +/- 6 years; mean +/- standard deviation) men (n = 23) and women (n = 31). Metabolic Insulin Sensitivity Index (S(I)) was determined from a frequently sampled insulin-assisted intravenous glucose tolerance test. Body fat mass and abdominal fat mass were determined from dual energy X-ray absorptiometry (DXA) scans. Anthropometric measures included waist and hip circumferences, height, and body weight.
  
  
  RESULTS
  Although waist circumference, waist index (waist circumference divided by height), and waist-hip ratio (WHR) were all lower in women than in men, there was no sex difference in DXA L1-L4 fat mass. In univariate analyses, S(I) was significantly inversely related with body weight, body mass index, waist circumference, waist index, percentage of total body and abdominal fat, and DXA L1-L4 fat mass but not with WHR. The DXA L1-L4 fat mass was identified as the best independent predictor of S(I), accounting for 41.2% of the variance (p <.0001) in a stepwise multiple regression model that controlled for sex.
  
  
  CONCLUSIONS
  WHR is not associated with S(I) in either men or women. Abdominal adiposity measured by DXA L1-L4 fat mass provides a sex-independent predictor of S(I) in older men and women.
authors.affiliation: Department of Internal Medicine, Division of Geriatrics, University of Michigan Health System, and the GRECC VA Ann Arbor Healthcare System, 48105, USA.
authors.forename: Cathy C
authors.initials: CC
authors.lastname: Lee
authors.forename: Scott G
authors.initials: SG
authors.lastname: Glickman
authors.forename: Donald R
authors.initials: DR
authors.lastname: Dengel
authors.forename: Michael D
authors.initials: MD
authors.lastname: Brown
authors.forename: Mark A
authors.initials: MA
authors.lastname: Supiano
mesh_terms: D000005:Abdomen; D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose