Detection of IL-20 and its receptors on psoriatic skin.
The aim of this study was to investigate the expression of interleukin-20 (IL-20) and its receptors on psoriatic skin by immunohistochemical analysis and to evaluate the correlation of CD8-positive T lymphocytes with epidermal proliferation. Overexpression of IL-20 and its receptors was detected in the keratinocytes of the lesional skin of psoriasis and spongiotic dermatitis. The expression pattern of IL-20 spreads throughout the whole layer of epidermis, while IL-19 was expressed in up to three or four layers suprabasally. The serum level of IL-20 in psoriatic patients was significantly lower than that in healthy controls. IL-20 upregulated KGF transcripts on CD8-positive T cells. We hypothesize that overexpression of IL-20 is correlated with keratinocyte proliferation that acts through their receptor complex expressed by keratinocytes themselves. Furthermore, IL-20 can stimulate CD8-positive lymphocytes to produce KGF, which may contribute to sustaining the hyperproliferative status of the keratinocytes.
Wei
Chi-Chen
CC
Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan, Taiwan.
Chen
Wei-Yu
WY
Wang
Yo-Ching
YC
Chen
Po-Jen
PJ
Lee
Julia Yu-Yun
JY
Wong
Tak-Wah
TW
Chen
Wen Chieh
WC
Wu
Jen-Chin
JC
Chen
Guan-Ying
GY
Chang
Ming-Shi
MS
Lin
Yu-Chih
YC
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism; D007378:Interleukins / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism; D011565:Psoriasis / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D018123:Receptors, Interleukin / Q000276:immunology / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000276:immunology / Q000378:metabolism*
C496453:FGF7 protein, human; C421250:IL19 protein, human; D007378:Interleukins; D018123:Receptors, Interleukin; C492510:interleukin-20 receptor; D051523:Fibroblast Growth Factor 7; D016753:Interleukin-10; D005346:Fibroblast Growth Factors; C422042:interleukin 20