AMPK and p53 help cells through lean times.
Cells that encounter low nutrient conditions often respond by arresting cell division or becoming apoptotic. Recent work by Jones and colleagues (Jones et al.,2005) reveals how the AMP-activated kinase mediates this process by phosphorylating and activating the tumor suppressor p53.
Thoreen
Carson C
CC
The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Sabatini
David M
DM
D055372:AMP-Activated Protein Kinases; D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D002477:Cells / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D009097:Multienzyme Complexes; D016159:Tumor Suppressor Protein p53; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose