[Effects of Bromazepam in qEEG by type writing].
The efficiency with which an information is processed by the brain's neural circuitry can be altered by neuromodulators. The use of Bromazepam in the pharmacological treatment of anxiety disorders is due to its anxiolytic property. However, the effects of this benzodiazepine in motor learning tasks are not entirely understood. In this context, the goal of this study was to assess the effects of Bromazepam (6 mg) on psychophysiological, behavioral, and electrophysiological variables, during the process of learning a motor task. The sample consisted of 26 healthy individuals, of both sexes, between 19 and 36 years of age. The control (placebo) and experimental (Bromazepam 6 mg) groups were submitted to a typewriting task, in a randomized, double-blind design. The results did not reveal differences for phychophysiological and behavioral variables between the groups. Statistical tests pointed out to an interaction between condition and moment, and a hemisphere main effect, i.e. a reduction of relative power in the right hemisphere. This reduction suggests a specialization of the neural circuitry in the hemisphere contralateral to the finger used in the task. Such reduction is independent from the drug administration.
Machado
Dionis
D
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Bastos
Victor Hugo
VH
Cunha
Marlo
M
Furtado
Vernon
V
Cagy
Maurício
M
Piedade
Roberto
R
Ribeiro
Pedro
P
D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects; D001960:Bromazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D004594:Electrophysiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009048:Motor Skills / Q000187:drug effects* / Q000502:physiology
D014151:Anti-Anxiety Agents; D001960:Bromazepam