Role of stereotactic radiosurgery in the treatment of brain metastases.
Stereotactic radiosurgery (SRS) is a highly conformal form of radiation therapy designed to deliver a high dose in a single treatment to the target volume while sparing adjacent normal tissues. Its role in the treatment of brain metastases continues to be defined, but the recently reported RTOG 95-08 trial demonstrated a survival benefit with the addition of SRS to whole-brain radiation therapy in select patients with a single brain metastasis, as well as a local control and palliative benefit in select patients with 1 to 3 brain metastases. The authors review the role of SRS in the treatment of brain metastases and discuss the use of SRS with or without whole-brain radiation therapy, optimal dose of SRS, SRS delivery methods, and selection of appropriate patients for SRS.
Hazard
Lisa J
LJ
Department of Radiation Oncology, Huntsman Cancer Hospital, Salt Lake City, Utah 84112, USA. lisa.hazard@hci.utah.edu
Jensen
Randy L
RL
Shrieve
Dennis C
DC
D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery*; D003704:Dementia / Q000453:epidemiology; D006801:Humans; D011832:Radiation Injuries / Q000453:epidemiology; D016634:Radiosurgery; D012189:Retrospective Studies; D016019:Survival Analysis