Troponin for prediction of cardiovascular collapse in acute colchicine overdose.
The use of colchicine, a treatment for acute gout and familial Mediterranean fever, is limited by its toxicity. A relatively low dose of colchicine may be fatal. After a colchicine overdose, monitoring should include 6-12 hourly serum troponin measurements. A rising troponin level predicts cardiovascular collapse and is an indication for more intensive management.
van Heyningen
C
C
University Hospital Aintree, Liverpool L9 7AL, UK. charles.vanheyningen@aht.nwest.nhs.uk
Watson
I D
ID
D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003078:Colchicine / Q000506:poisoning*; D062787:Drug Overdose / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D006074:Gout Suppressants / Q000506:poisoning*; D006323:Heart Arrest / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D006074:Gout Suppressants; D019210:Troponin I; D003078:Colchicine