Reproducing cardiac restitution properties using the Fenton-Karma membrane model.
Modern models of cardiac membranes are often highly complex and computationally expensive, particularly when used in long simulations of spatially extended models of cardiac tissue. Therefore, there is a need for simpler membrane models that preserve the features of the complex models deemed important. This communication describes an empirical procedure that was used to choose the parameters of the three-variable Fenton-Karma (FK3V) model to reproduce the restitution properties of the Courtemanche-Ramirez-Nattel model of atrial tissue. The resulting parameter values for the FK3V model and the sensitivity table for all its parameters are provided. Thus, this study gives insight into the behavior of the FK3V model and the effect of its parameters on restitution properties.
Oliver
Robert A
RA
Department of Biomedical Engineering, Duke University, P.O. Box 90281, Durham, NC 27708, USA. robert.oliver@duke.edu
Krassowska
Wanda
W
D000818:Animals; D016275:Atrial Function / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008955:Models, Cardiovascular