Conformational diastereoisomerism in a chiral pretzelane.
The introduction of a stereogenic center by a stereospecific synthesis into an optically active, donor-acceptor pretzelane, that exhibits helicity as well as fixed chirality, leads to a marked preference for one conformational diastereoisomer over the other in both acetone and dimethylsulfoxide that can be understood from computational models.
Liu
Yi
Y
California NanoSystems Institute and the Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
Vignon
Scott A
SA
Zhang
Xiyun
X
Houk
K N
KN
Stoddart
J Fraser
JF