[Protective effects of gastrodin on the cellular model of Alzheimer's disease induced by Abeta25-35].
OBJECTIVE
To assess the effects of gastrodin (GAS) on the induced neurons of Alzheimer's disease (AD).


METHODS
The cellular model of AD was established with primary cultured cerebral cortical and hippocampal cells induced by Abeta325-35. The total saponin ginseng was taken as positive control. The effects of gastrodin on the cellular model of AD were studied by morphological observation and biochemical methods.


RESULTS
Compared with the control, the cellular model induced by Abeta25-35 showed remarkable morphological changes, significant increase in LDH release, and significant decrease in cell survival. When different doses of gastrodin, total saponin of ginseng were added beforehand, significant decrease in LDH release and significant increase in cell survival were noted by comparison with the experimental control, which indicated that the two medicines could protect the cells from the damage induced by Abeta25-35 to some extent.


CONCLUSIONS
The results suggested that gastrodin has potential effects on the prevention and therapy of AD.
Liu
Zhong-hua
ZH
Department of Human Anatomy, Medical School of Xi'an Jiaotong University, Xi'an 710061, China.
Hu
Hai-tao
HT
Feng
Gai-feng
GF
Zhao
Zhi-ying
ZY
Mao
Nai-ying
NY
D000544:Alzheimer Disease / Q000139:chemically induced / Q000473:pathology*; D016229:Amyloid beta-Peptides; D000818:Animals; D000831:Animals, Newborn; D001592:Benzyl Alcohols / Q000494:pharmacology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D005960:Glucosides / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology; D009474:Neurons / Q000166:cytology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016229:Amyloid beta-Peptides; D001592:Benzyl Alcohols; D005960:Glucosides; D018696:Neuroprotective Agents; C045345:gastrodin