title: Designing effective hybrid toxins.
abstract: A study of a well-designed androgen-mustard conjugate provides evidence supporting a novel mechanism for its selective toxicity in androgen-receptor-positive cancer cells. This represents a solid step forward on the path toward effective hybrid toxins for targeted cancer therapy.
authors.affiliation: Department of Chemistry, University of Illinois, 600 South Mathews , Urbana, Illinois 61801, USA. jkatzene@uiuc.edu
authors.forename: John A
authors.initials: JA
authors.lastname: Katzenellenbogen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D000922:Immunotoxins / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000922:Immunotoxins