Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland.
To define the role of surgical management of lung metastases in ACC. Twenty ACC patients referred to lung metastasectomy were retrospectively reviewed. Twenty-six operations were performed; at the first metastasectomy, a resection with clear margins (R0) was achieved in 11 patients (55%), 3 are alive and well. Four out of 9 patients with residual disease (R2) are still alive. Median survival after metastasectomy was 78 and 52 months for R0 and R2 (p=0.4); median freedom from progression (FFP) in R0 and R2 groups was 30 and 15 months (p=0.2), respectively. A better outcome was obtained for patients with a disease-free interval 36 months and 6 metastases and bilateral involvement were critical in achieving a R0 intervention. Lung metastasectomy provided a prolonged FFP in a high selected subset of patients with ACC. However, if this could be translated into a survival benefit, it is still to be demonstrated.
Locati
Laura D
LD
Medical Oncology Unit/Head and Neck Unit, Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy. laura.locati@istitutotumori.mi.it
Guzzo
Marco
M
Bossi
Paolo
P
Massone
Paolo P Brega
PP
Conti
Barbara
B
Fumagalli
Elena
E
Bareggi
Claudia
C
Cantù
Giulio
G
Licitra
Lisa
L
D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000556:secondary / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008168:Lung / Q000601:surgery*; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms