Mycobacterial manipulation of the host cell.
Phagosome biogenesis, the process by which macrophages neutralize ingested pathogens and initiate antigen presentation, has entered the field of cellular mycobacteriology research largely owing to the discovery 30 years ago that phagosomes harboring mycobacteria are refractory to fusion with lysosomes. In the past decade, the use of molecular genetics and biology in different model systems to study phagosome biogenesis have made significant advances in understanding subtle mechanisms by which mycobacteria inhibit the maturation of its phagosome. Thus, we are beginning to appreciate the extent to which these pathogens are able to interfere with innate immune responses and manipulate defense mechanisms to enhance their survival within the human host cell. Here, we summarize current knowledge about phagosome maturation arrest in infected macrophages and the subsequent attenuation of the macrophage-initiated adaptive anti-mycobacterial immune defenses.
Hestvik
Anne Lise K
AL
Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, 2733 Heather St. Vancouver, BC, Canada V5Z 3J5.
Hmama
Zakaria
Z
Av-Gay
Yossef
Y
D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*; D009163:Mycobacterium bovis / Q000254:growth & development / Q000472:pathogenicity*; D009169:Mycobacterium tuberculosis / Q000254:growth & development / Q000472:pathogenicity*; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology*; D014376:Tuberculosis / Q000382:microbiology