title: Recent immunohistochemical markers in the differential diagnosis of primary and metastatic carcinomas of the liver.
abstract: Differential diagnosis of primary and metastatic carcinomas of the liver can be problematic and may require immunohistochemical work-up. Recently, new immunohistochemical markers have been introduced with promising results in this area. We studied three of these markers, human hepatocyte antibody (HepPar-1), human epithelial-related antigen (MOC-31), and thyroid transcription factor-1 (TTF-1), in cell-block sections of fine-needle aspirations from 30 hepatocellular carcinomas and 27 metastatic carcinomas from various sites. Of 27 metastatic carcinomas, all but one were positive for MOC-31 and, all but one were negative for HepPar-1. TTF-1 was positive only in the nuclei of metastatic poorly differentiated neuroendocrine carcinoma from the lung. Of 30 hepatocellular carcinomas, 26 were positive for HepPar-1 and all were negative for MOC-31, while TTF-1 showed cytoplasmic staining in 23 cases. HepPar-1, MOC-31, and TTF-1 are complementary markers in the differential diagnosis of primary and metastatic carcinomas of the liver, with high sensitivity and specificity.
authors.affiliation: Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. mgokden@uams.edu
authors.forename: Murat
authors.initials: M
authors.lastname: Gokden
authors.forename: Anjali
authors.initials: A
authors.lastname: Shinde
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D009362:Neoplasm Metastasis / Q000473:pathology*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor