Body size and composition and the risk of lymphohematopoietic malignancies.
Reports of associations between body size and composition and risk of lymphohematopoietic malignancies have been inconsistent. In a prospective study of 40,909 people aged 27-75 years and followed up for an average of 8.4 years, we measured fat mass and fat-free mass (using bioelectrical impedance analysis) and measured waist circumference directly. All malignancies were ascertained via the population cancer registry. The risk of myeloid leukemia was positively associated with body mass index (compared with those < 25 kg/m2, overweight and obese persons' hazard ratios [HRs] = 5.3, 95% confidence interval [CI] = 1.9 to 15.2 and HR = 5.0, 95% CI = 1.6 to 15.5, respectively; P = .006), fat-free mass (per 10-kg increase HR = 1.83, 95% CI = 1.15 to 2.90; P = .01), and waist circumference (per 10-cm increase HR = 1.35, 95% CI = 1.06 to 1.72; P = .02). Lymphoproliferative malignancies and subgroups showed little relationship with body size.
MacInnis
Robert J
RJ
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia.
English
Dallas R
DR
Hopper
John L
JL
Giles
Graham G
GG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D015992:Body Mass Index; D049628:Body Size; D016001:Confidence Intervals; D017097:Electric Impedance; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D014739:Victoria / Q000453:epidemiology; D049629:Waist-Hip Ratio