A small gem with great powers: geminin keeps neural progenitors thriving.
Timing and extent of cell expansion and specialization in the developing nervous system are tightly controlled. In a recent issue of Genes and Development, Seo and coworkers (2005a) show that geminin (Gem), a protein involved in cell cycle control, also regulates the transition from proliferating neural progenitors to differentiating neurons.
Aigner
Stefan
S
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. gage@salk.edu
Gage
Fred H
FH
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D064248:Geminin; D018507:Gene Expression Regulation, Developmental; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D014981:Xenopus; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; C577998:GMNN protein, Xenopus; D064248:Geminin; D029867:Xenopus Proteins