title: Failure of thromboprophylaxis in pregnancy caused by dual deficiencies of protein S and protein C.
abstract: Protein S and protein C deficiencies are commonly identified biochemical abnormalities associated with a hypercoagulable state; they result in an increased incidence of venous thromboembolism. We report the case of a pregnant woman with dual deficiencies of protein S and protein C, who encountered a venous thromboembolism 7 days postpartum despite of the use of danaparoid.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Morikawa
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Emi H
authors.initials: EH
authors.lastname: Kato
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Wada
authors.forename: Shigenori
authors.initials: S
authors.lastname: Suzuki
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakuragi
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
mesh_terms: D000328:Adult; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D049590:Postpartum Period / Q000187:drug effects; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011292:Premedication; D020151:Protein C Deficiency / Q000150:complications; D018455:Protein S Deficiency / Q000150:complications; D013927:Thrombosis / Q000188:drug therapy / Q000517:prevention & control*; D017211:Treatment Failure; D020246:Venous Thrombosis / Q000209:etiology
chemical_list: D006493:Heparin