[Influences of cardiopulmonary bypass in elderly patients].
Organ hypofunction by aging exaggerate damages, which are caused by cardiopulmonary bypass. The main cause of organ dysfunction after cardiopulmonary bypass is systemic inflammatory response, which is induced by continuous interaction of blood with unphysiologic surfaces, shear stress to blood cells, and incorporation of abnormal substances. To reduce the postoperative complications after cardiovascular surgery in elderly patients, intensive and careful control of cardiopulmonary bypass and several kinds of anti-inflammatory treatment are important.
Tabayashi
Koichi
K
Department of Cardiovascular Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D013504:Cardiovascular Surgical Procedures; D002319:Cardiovascular System / Q000503:physiopathology; D003165:Complement System Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007937:Leukapheresis; D008099:Liver / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage; D010974:Platelet Aggregation; D011183:Postoperative Complications / Q000209:etiology* / Q000517:prevention & control; D012137:Respiratory System / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology* / Q000517:prevention & control
D016207:Cytokines; D003165:Complement System Proteins; D008775:Methylprednisolone