[Morphological changes of human erythrocytes during cold storage].
The work illustrates the sensitivity of microscopy method for intravital analysis of quantitative ratio of peripheric blood erythrocyte forms in patients with vibration disease when elucidating the role of morphological state of these cells in the formation of the pathological clinical manifestations. We have examined 61 patients with vibration disease due to the effect of local vibration. It was demonstrated that vibration disease development is accompanied by a progressive increase of erythrocyte invaginated forms: stomatocytes in patient blood. It was established, that a loss of hypothermic resistance of erythrocyte form could serve as a diagnostic test of the pathological process manifestation degree. Therefore, if the accumulation rate (C, % per day) of prehemolytic erythrocyte forms under conditions of blood hypothermic storage (4 degrees C) is within 3.5 < C < 5.0 interval, the 1st stage of the disease is detected while the IInd stage of disease is detected when C > 5.
Kulieshova
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D000328:Adult; D003080:Cold Temperature; D004912:Erythrocytes / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000175:diagnosis*; D012212:Rheology; D013048:Specimen Handling; D014732:Vibration / Q000009:adverse effects*