trans-5-aminopipecolyl-aegPNA chimera: design, synthesis, and study of binding preferences with DNA/RNA in duplex/triplex mode.
The design and synthesis of novel chiral PNA monomer based on trans-5-aminopipecolic acid is reported. The trans diequatorial disposition of the 1,4 ring substituents in six-membered 5-aminopipecolic acid derivative could be favorable over trans 1,3 axial-equatorial disposition in 4-aminopipecolic acid of PNA. Studies on the synthesis of trans-4/5-aminopipecolyl PNA-eagPNA chimeras and their binding preferences to DNA/RNA in duplex/triplex modes are described.
Lonkar
Pallavi S
PS
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India. va.kumar@ncl.res.in
Kumar
Vaijayanti A
VA
D004247:DNA / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization
D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA