title: Oxa1/Alb3/YidC system for insertion of membrane proteins in mitochondria, chloroplasts and bacteria (review).
abstract: Recent studies have shown that there is a pathway that is evolutionarily conserved for the insertion of proteins into the membrane in mitochondria, chloroplasts, and bacteria. In this pathway, the Oxa1/Alb3/YidC proteins are believed to function as membrane insertases that play an important role in the membrane protein biogenesis of respiratory and energy transduction proteins. Additional roles of the Oxa1/Alb3/YidC members may be in the lateral integration of proteins into the lipid bilayer, and in the folding and assembly of proteins into membrane protein complexes.
authors.affiliation: Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Yi
authors.forename: Ross E
authors.initials: RE
authors.lastname: Dalbey
mesh_terms: D029681:Arabidopsis Proteins / Q000502:physiology; D001419:Bacteria / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D002736:Chloroplasts / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000502:physiology; D029968:Escherichia coli Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology; D024101:Mitochondrial Proteins / Q000378:metabolism* / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D021381:Protein Transport; D020524:Thylakoids / Q000502:physiology
chemical_list: C106404:ALBINO 3 protein, Arabidopsis; D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; C090858:OXA1 protein; C412443:YIDC protein, E coli; D003576:Electron Transport Complex IV