Improvement of T1 determination of hyperpolarized 129Xe in mouse brain under controlled-flow.
The method of determining the longitudinal relaxation time of hyperpolarized 129Xe in the mouse brain has been established in vivo with the ventilation technique under controlled-flow conditions. The uptake and washout processes for nine mice were traced through observation of time-dependent changes in NMR (nuclear magnetic resonance) signal amplitudes and analyzed by means of a two-compartment model, thus providing the quantitative value of 14.1+/-1.6 s as the relaxation time.
Kimura
Atsuomi
A
Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. kimura@sahs.med.osaka-u.ac.jp
Wakayama
Tetsuya
T
Narazaki
Michiko
M
Kawata
Yoko
Y
Ueyama
Tsuyoshi
T
Fujiwara
Hideaki
H
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019047:Phantoms, Imaging; D014979:Xenon Isotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003287:Contrast Media; D014979:Xenon Isotopes