One-step assembly of functionalized gamma-butyrolactones from benzoins or benzaldehydes via an N-heterocyclic carbene-mediated tandem reaction.
We describe here a direct, efficient, one-step construction of gamma,gamma-difunctionalized gamma-butyrolactones from benzoins or benzaldehydes via a tandem reaction promoted by 1,3-dimethyl imidazolin-2-ylidene, an N-heterocyclic carbene (NHC). [reaction: see text]
Ye
Wei
W
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China 200032.
Cai
Guanliang
G
Zhuang
Zeyang
Z
Jia
Xueshun
X
Zhai
Hongbin
H
D015107:4-Butyrolactone / Q000138:chemical synthesis*; D001547:Benzaldehydes / Q000737:chemistry*; D001573:Benzoin / Q000031:analogs & derivatives* / Q000737:chemistry*; D002384:Catalysis; D006838:Hydrocarbons / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure
D001547:Benzaldehydes; D006838:Hydrocarbons; C030011:carbene; D001573:Benzoin; D015107:4-Butyrolactone; D008697:Methane