title: Diagnostic model for sensitization in workers exposed to occupational high molecular weight allergens.
abstract: BACKGROUND
  Occupational allergy has great impact on workers exposed to high molecular weight (HMW) allergens. The present study is aimed to develop and validate a generic diagnostic model for sensitization to HMW allergens, defined as positive IgE.
  
  
  METHODS
  The model was developed in pooled data from Dutch laboratory animal (LA) workers and bakers using logistic regression analysis. Validity was assessed internally by bootstrapping procedure, and externally in British LA workers.
  
  
  RESULTS
  The model included working hours/week, work-related symptoms, total IgE, and IgE to common allergen. Significant interactions between the type of work and the predictors resulted in different scores for LA workers and bakers. Internal and external validation showed that the model was satisfactorily calibrated and discriminated between workers at high and low risk of being sensitized.
  
  
  CONCLUSIONS
  It is possible to develop a generic model for sensitization to occupational HMW allergens. However, the weighing of predictors differs across specific work environments.
authors.affiliation: Institute for Risk Assessment Sciences, Environmental and Occupational Health Group, Utrecht University, Utrecht, The Netherlands.
authors.forename: Eva
authors.initials: E
authors.lastname: Suarthana
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Vergouwe
authors.forename: Mark
authors.initials: M
authors.lastname: Nieuwenhuijsen
authors.forename: Dick
authors.initials: D
authors.lastname: Heederik
authors.forename: Diederick E
authors.initials: DE
authors.lastname: Grobbee
authors.forename: Evert
authors.initials: E
authors.lastname: Meijer
mesh_terms: D000328:Adult; D000485:Allergens; D003296:Cooking; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D016015:Logistic Models; D017056:Medical Laboratory Personnel; D008970:Molecular Weight; D016273:Occupational Exposure
chemical_list: D000485:Allergens; D007073:Immunoglobulin E