Expression patterns of nm23 genes during mouse organogenesis.
Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis. Whereas nm23-M1 and -M3 are preferentially expressed in the nervous and sensory systems, nm23-M2 mRNA is found ubiquitously. Irrespective of the developmental state studied, nm23-M4 mRNA is only expressed at low levels in a few embryonic organs. In the cerebellum and cerebral cortex, nm23-M1, -M2, and -M3 are present in the neuronal differentiation layer, whereas nm23-M4 mRNA is distributed in the proliferating layer. Thus, nm23 mRNA is differentially expressed, and the diverse NDPK isoforms are sequentially involved in various developmental processes.
Amrein
Lilian
L
EA DRED 483, Laboratoire de Biologie de la Différenciation et du Développement, Université Victor Ségalen, Bordeaux 2, 33 076, Bordeaux Cedex, France.
Barraud
Perrine
P
Daniel
Jean-Yves
JY
Pérel
Yves
Y
Landry
Marc
M
D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002490:Central Nervous System / Q000196:embryology* / Q000378:metabolism*; D015870:Gene Expression; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics* / Q000378:metabolism; D054778:NM23 Nucleoside Diphosphate Kinases; D061107:Nucleoside Diphosphate Kinase D; D038081:Organogenesis / Q000502:physiology*; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D054778:NM23 Nucleoside Diphosphate Kinases; D020033:Protein Isoforms; D012333:RNA, Messenger; C517939:Nme1 protein, mouse; C517941:Nme2 protein, mouse; C517944:Nme3 protein, mouse; C517947:Nme4 protein, mouse; D061107:Nucleoside Diphosphate Kinase D; D020559:Monomeric GTP-Binding Proteins