[Ginseng modulates the immune response via its effect on cytokine production--secondary publication].
Ginseng has been shown to modulate the immune system. In this study, ginseng"s effects against chronic P. aeruginosa lung infection in animal models and its cytokine-modulating effects on leukocytes were investigated. Leukocytes cultured with ginseng produced more interleukin-12. Animal models treated with ginseng s.c. showed a much faster bacterial clearance, milder lung pathology, activation of phagocytes and a Th1 immune response. These results suggest that ginseng treatment induced a Th1-like immune response, which improved the pathologic course in our animal models.
Song
Zhijun
Z
H:S Rigshospitalet, Diagnostisk Center, Klinisk Mikrobiologisk Afdeling og Epidemiklinikken. zhijun.song@rh.hosp.dk
Moser
Claus
C
Wu
Hong
H
Larsen
Maria Waldorff
MW
Johansen
Helle Krogh
HK
Faber
Viggo
V
Kharazmi
Arsalan
A
Høiby
Niels
N
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D018664:Interleukin-12 / Q000096:biosynthesis; D005894:Panax; D010586:Phagocytes / Q000276:immunology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000276:immunology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology
D016207:Cytokines; D007155:Immunologic Factors; D010936:Plant Extracts; D018664:Interleukin-12