title: Immune regulation of viral infection and vice versa.
abstract: In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicate the virus. Analysis of these issues is key to understanding acute and chronic diseases caused by viruses. Two concepts drive our approach: (1) the simultaneous analysis of immune and viral mechanisms allows novel insights, and (2) genetic tests in vivo are necessary to establish mechanisms.
authors.affiliation: Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. virgin@wustl.edu
authors.forename: Herbert W
authors.initials: HW
authors.lastname: Virgin
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000276:immunology / Q000821:virology; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology; D018142:Gammaherpesvirinae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000276:immunology / Q000821:virology; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000821:virology; D051379:Mice; D029322:Norovirus / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014765:Viral Vaccines / Q000494:pharmacology; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D017735:Virus Latency / Q000276:immunology; D014779:Virus Replication / Q000276:immunology
chemical_list: D014765:Viral Vaccines