title: [Study on the mechanism of oocyte aneuploidy by spectral karyotyping].
abstract: OBJECTIVE
  To establish the method of detecting oocyte aneuploidy by spectral karyotyping (SKY).
  
  
  METHODS
  The unfertilized oocytes were fixed 1-2 days after oocyte retrieval. Spectral karyotyping was performed according to the protocol.
  
  
  RESULTS
  64% of oocytes were normal, 36% of oocytes were aneuploidy, of which 22% were due to nondisjunction and 14% unbalanced predivision.
  
  
  CONCLUSIONS
  SKY is an effective method for detecting oocyte aneuploidy. Both nondisjunction and unbalanced predivision are involved in oocyte aneuploidy formation.
authors.affiliation: Department of Gynecology and Obstetrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030 PR China. chenwenyyy@yahoo.com
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.forename: Gui-jin
authors.initials: GJ
authors.lastname: Zhu
authors.forename: Liselotte
authors.initials: L
authors.lastname: Mettler
mesh_terms: D000782:Aneuploidy; D005260:Female; D006801:Humans; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D015203:Reproducibility of Results; D032681:Spectral Karyotyping / Q000379:methods*