Pathogenesis and treatment of human T-cell leukemia virus infection.
The pathogenesis of human T-cell leukemia virus (HTLV)-induced adult T-cell leukemia-lymphoma (ATLL) was explored using an infectious molecular viral clone and a transgenic mouse model. Activation of nuclear factor-kappaB by the HTLV transcriptional transactivator protein Tax was found to be important for lymphocyte immortalization and tumorigenesis. Interferon-gamma regulates tumor development owing primarily to angiostatic effects. Translational clinical studies of chemotherapy, interferon-alpha, and nucleoside reverse transcriptase inhibitors have also assisted in identifying the pathogenic features of ATLL.
Ratner
Lee
L
Division of Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. lratner@im.wustl.edu
D000818:Animals; D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004195:Disease Models, Animal; D016356:Gene Products, tax / Q000378:metabolism; D016355:Genes, pX; D015490:HTLV-I Infections / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism
D044966:Anti-Retroviral Agents; D000970:Antineoplastic Agents; D016356:Gene Products, tax; D016328:NF-kappa B