title: A new reactivity pattern for vinyl bromides: cine-substitution via palladium catalysed C-N coupling/Michael addition reactions.
abstract: Palladium catalysed C-N bond formation can be used to convert vinyl bromides to the corresponding enamines, which are reacted in situ with alkylidene malonates to provide Michael adducts. The overall transformation results in cine-substitution of the starting vinyl bromide.
authors.affiliation: Department of Chemistry, University of Bath, Bath BA2 7AY, UK. m.c.willis@bath.ac.uk
authors.forename: Michael C
authors.initials: MC
authors.lastname: Willis
authors.forename: Jay
authors.initials: J
authors.lastname: Chauhan
authors.forename: William G
authors.initials: WG
authors.lastname: Whittingham
mesh_terms: D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis*; D007659:Ketones / Q000138:chemical synthesis*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004952:Esters; D007659:Ketones; D014753:Vinyl Compounds; D010165:Palladium; C003763:vinyl bromide