Longitudinal study to explore chronic neuropsychologic effects on solvent exposed workers.
OBJECTIVE
The aim of the study was to examine possible neurotoxic effects on the central nervous system (CNS) in relation to a chronic solvent exposure at the workplace.


METHODS
The collective included 127 workers exposed to solvent mixtures, such as spray painters and printers. They were examined twice by means of a physical examination, neuropsychological testbattery, biological and air monitoring.


RESULTS
Major component of the solvents were white spirits in concentrations up to 127 ppm in air and 2,666 microg/l in blood. Single substances were mainly toluene and xylenes in concentrations below current threshold values at the workplace. During the 2 yr interval, the concentrations of solvents decreased, and no significant associations between the neuropsychological tests and the solvent exposure were found. Regarding the whole working history of each participant, we found a significant reduction on information processing velocity and performance in the trailmaking test, as well as more complaints of workers with higher solvent exposure in the past.


CONCLUSIONS
A slight increase of subjective complaints and a deteriorated power of concentration seems to be associated with chronic solvent exposure.
Ihrig
Andreas
A
Institute and Outpatient Clinic of Occupational and Social Medicine, University Hospital Heidelberg, Hospitalstrasse 1, 69115 Heidelberg, Germany.
Dietz
Michael C
MC
Bader
Michael
M
Triebig
Gerhard
G
D000328:Adult; D002490:Central Nervous System / Q000187:drug effects; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009498:Neurotoxins / Q000009:adverse effects*; D016273:Occupational Exposure; D012997:Solvents / Q000506:poisoning*
D009498:Neurotoxins; D012997:Solvents