title: Effects of acute administration of methamphetamine on Narp mRNA in rat brain.
abstract: Narp (neuronal activity-regulated pentraxin) is a secreted immediate early gene product functioning as a cluster factor for the AMPA receptor subtype of glutamate receptors. This study was designed to examine the effects of acute administration of methamphetamine (MAP) on the Narp gene in rat brain using reverse transcription - polymerase chain reaction (RT-PCR). Acute administration of MAP [4.6 mg/kg, intraperitoneally (i.p.)] increased Narp mRNA in the prefrontal cortex, whereas the same treatment with MAP decreased Narp mRNA in the hippocampus. Therefore, Narp gene could be involved in the MAP-induced effects.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Tottori Unversity, Tottori, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iwata
authors.forename: Chiko
authors.initials: C
authors.lastname: Shinbori
authors.forename: Gen-I
authors.initials: GI
authors.lastname: Hazama
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Shirayama
authors.forename: Ryuzou
authors.initials: R
authors.lastname: Kawahara
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism*; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D000099153:Pentraxins