title: Use of a soft reservoir bag in a fully heparin-coated closed-loop cardiopulmonary bypass system for distal aortic perfusion during aortic surgery.
abstract: A fully heparin-coated closed-loop cardiopulmonary bypass system has recently been introduced into clinical practice. Without a venous reservoir, however, it does not allow control of the preload to the heart. We connected a soft reservoir bag in parallel with a centrifugal pump to enable preload control and clinically evaluated this modified system for distal aortic perfusion during aortic surgery. We have used the modified system in 17 patients since November 2002. For venous drainage, we use long narrow cannulae (21 +/- 2 French). We administered 1 mg/kg heparin without cardiotomy suction and 2 mg/kg heparin with suction. We compared the clinical results with those in 13 patients who underwent distal aortic perfusion with an open cardiopulmonary bypass circuit between January 2002 and February 2004. We also analyzed factors affecting the coagulation system in these 30 patients using multiple regression analysis. With the modified system, venous drainage was adequate despite the use of smaller cannulae, and heparin reduction was not associated with thrombotic complication or elevated D-D dimer levels. Abrupt rises in proximal aortic pressure on aortic cross-clamping could be avoided by allowing blood to drain into the soft reservoir bag. Clinical results were not different from those with an open system. In the multiple regression analysis, the peak activated clotting time tended to correlate with postoperative platelet counts. This system is effective in controlling the preload to the heart and allows the safe reduction of heparin dosage. It therefore seems useful for distal aortic perfusion during aortic surgery.
authors.affiliation: Department of Cardiovascular Surgery, Hokkaido University Hospital, Kita-ku, Sapporo 060-8648, Japan. shiyanor@med.hokudai.ac.jp
authors.forename: Norihiko
authors.initials: N
authors.lastname: Shiiya
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kunihara
authors.forename: Keishu
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D001011:Aorta / Q000601:surgery*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000295:instrumentation*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000295:instrumentation / Q000379:methods*
chemical_list: D000925:Anticoagulants; D006493:Heparin