title: How increased pertussis vaccination coverage is changing the epidemiology of pertussis in Italy.
abstract: The epidemiology of pertussis in Italy is described by using data from the statutory notification system and from seroepidemiology studies. Starting from the 1990s, the incidence of pertussis in Italy has shown a sharp decline and is now at the lowest level ever reached. During this time period vaccination coverage has increased from 88% in 1998 to 95% in 2003. In 1996-97, the prevalence of subjects with levels of IgG antibodies against PT greater than 2EU/ml was 77.6%. The increase in vaccination coverage will probably change the pattern of disease transmission and increase the number of susceptible adults, unless administration of booster doses to adolescents and adults is considered.
authors.affiliation: Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. rota@iss.it
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Rota
authors.forename: Fortunato
authors.initials: F
authors.lastname: D'Ancona
authors.forename: Marco
authors.initials: M
authors.lastname: Massari
authors.forename: Donatella
authors.initials: D
authors.lastname: Mandolini
authors.forename: Anna
authors.initials: A
authors.lastname: Giammanco
authors.forename: Patrizia
authors.initials: P
authors.lastname: Carbonari
authors.forename: Stefania
authors.initials: S
authors.lastname: Salmaso
authors.forename: Marta Luisa
authors.initials: ML
authors.lastname: Ciofi degli Atti
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D037141:Mandatory Programs; D032541:Mass Vaccination; D010567:Pertussis Vaccine; D011159:Population Surveillance; D012042:Registries; D016036:Seroepidemiologic Studies; D014917:Whooping Cough / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine