title: Pulse requirements for x-ray diffraction imaging of single biological molecules.
abstract: In this paper we estimate the required pulse parameters for the future application of x-ray free electron lasers to imaging single biological molecules. The parameters are determined by a tradeoff between minimizing image degradation due to damage and maximizing the image signal-to-noise ratio. We discuss several means to alleviate the pulse requirements, and compare the requirements with parameters of two planned x-ray lasers.
authors.affiliation: Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551, USA.
authors.forename: Stefan P
authors.initials: SP
authors.lastname: Hau-Riege
authors.forename: Richard A
authors.initials: RA
authors.lastname: London
authors.forename: Gosta
authors.initials: G
authors.lastname: Huldt
authors.forename: Henry N
authors.initials: HN
authors.lastname: Chapman
mesh_terms: D001704:Biopolymers / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects*; D003198:Computer Simulation; D018499:Linear Energy Transfer; D008956:Models, Chemical; D008968:Molecular Conformation / Q000528:radiation effects; D010316:Particle Size; D014961:X-Ray Diffraction / Q000379:methods*; D014965:X-Rays
chemical_list: D001704:Biopolymers