title: Gastrinoma of the stomach: a case report.
abstract: Gastrinomas of the stomach are extremely rare endocrine tumors producing Zollinger-Ellison syndrome. We report here the case of a patient with gastrinoma of the stomach who presented regional and hepatic metastases at the time of diagnosis. The endocrine tumor was discovered incidentally 8 yr after the onset of symptoms related to peptic ulcer, which responded to medical treatment with a proton pump inhibitor. Surgery did not cure the patient, as demonstrated by provocative tests showing serum gastrin responses indicative of residual disease. A long-term treatment with the somatostatin analog lanreotide induced a biochemical response and was associated with a substantially stable disease.
authors.affiliation: Department of Medicine and Gastroenterology, Bellaria Hospital, University of Bologna, 40139 Bologna, Italy. andrea.tartaglia@hotmail.com
authors.forename: Andreas
authors.initials: A
authors.lastname: Tartaglia
authors.forename: Chiara
authors.initials: C
authors.lastname: Vezzadini
authors.forename: Silvia
authors.initials: S
authors.lastname: Bianchini
authors.forename: Paolo
authors.initials: P
authors.lastname: Vezzadini
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005743:Gastrectomy; D015408:Gastrinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D010437:Peptic Ulcer; D010456:Peptides, Cyclic / Q000627:therapeutic use; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin