Synthesis of benzo[b]furans via CuI-catalyzed ring closure.
A wide variety of benzo[b]furans were synthesized efficiently via a CuI-catalyzed ring closure of 2-haloaromatic ketones. The methodology was tolerant to various functional groups, affording benzofurans in 72-99% yields.
Chen
Cheng-yi
CY
Department of Process Research, Merck & Co. Inc., P.O. Box 2000, Rahway, NJ 07065, USA. cheng_chen@merck.com
Dormer
Peter G
PG
D001572:Benzofurans / Q000138:chemical synthesis*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy
D001572:Benzofurans; D003300:Copper