Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin.
Quinine remains a reliable treatment for falciparum malaria in most parts of the world. We report recrudescence of imported Plasmodium falciparum malaria following quinine treatment in the context of concurrent phenytoin use. Supported by a subtherapeutic quinine level, we hypothesise that a drug interaction with phenytoin may compromise the efficacy of quinine in the treatment of malaria.
Fabre
C
C
Department of Paediatric Emergency Medicine, Guy's and St Thomas' NHS Foundation Trust, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Criddle
J
J
Nolder
D
D
Klein
J L
JL
D000927:Anticonvulsants / Q000627:therapeutic use; D000962:Antimalarials / Q000627:therapeutic use*; D004347:Drug Interactions; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D016779:Malaria, Cerebral / Q000188:drug therapy; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010672:Phenytoin / Q000627:therapeutic use; D011803:Quinine / Q000097:blood / Q000627:therapeutic use*; D012008:Recurrence
D000927:Anticonvulsants; D000962:Antimalarials; D010672:Phenytoin; D011803:Quinine