title: Snapshot of the allele-specific variation in human gene expression.
abstract: The analysis of gene differential expression is complicated by the potentially subtle differences associated with alterations in a single allele as well as by variations between individuals that arise from environmental or physiological factors. To circumvent these analytic problems, a method, named allele-specific differential expression analysis, was developed to compare the relative expression levels of two alleles of the same gene within the same cellular sample. The studies of allele-specific expression revealed that differential expression is relatively common in the human population.
authors.affiliation: Department of Pathology, Duke University Meeical Center, Durham, NC, USA.
authors.forename: Hai
authors.initials: H
authors.lastname: Yan
mesh_terms: D000483:Alleles; D002460:Cell Line; D004247:DNA / Q000032:analysis; D015870:Gene Expression; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D004247:DNA