Antibody class switch recombination: roles for switch sequences and mismatch repair proteins.
Mechanisms and targeting of antibody class switch DNA recombination are reviewed. Particular emphasis is on the roles for the DNA sequences comprising switch (S) regions, including the S-region tandem repeats, and on the roles of proteins that are involved in both DNA mismatch repair and in class switch recombination.
Min
Irene M
IM
Genetics Program, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Selsing
Erik
E
D000818:Animals; D020137:Base Pair Mismatch; D003564:Cytidine Deaminase / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D017578:Immunoglobulin Class Switching; D007134:Immunoglobulin Switch Region; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D011995:Recombination, Genetic; D020080:Tandem Repeat Sequences; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D004247:DNA; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase