Syphilis in the HIV-infected patient: an update on epidemiology, diagnosis, and management.
After a decade of unprecedented declines, incidence of early-stage syphilis in the United States and Europe has increased significantly since 2000. These cases have occurred at disproportionately elevated rates among people infected with HIV. Speculation continues as to whether the clinical spectrum of syphilis is qualitatively different among those individuals who are HIV infected. Recent data suggest that individuals who are immune compromised because of HIV have a higher likelihood of developing neurosyphilis. Recommendations for treatment of syphilis remain the same for patients with and without HIV.
Zellan
Jonathan
J
State University of New York Downstate Medical Center, Box 1187, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Augenbraun
Michael
M
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D003430:Cross-Sectional Studies; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D015994:Incidence; D007273:Injections, Intramuscular; D009494:Neurosyphilis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D010401:Penicillin G Benzathine / Q000008:administration & dosage; D017410:Practice Guidelines as Topic; D011339:Probenecid / Q000008:administration & dosage; D013587:Syphilis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D013591:Syphilis, Cutaneous / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission; D013592:Syphilis, Latent / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D016896:Treatment Outcome
D000658:Amoxicillin; D004318:Doxycycline; D011339:Probenecid; D010401:Penicillin G Benzathine