title: Spectral priors improve near-infrared diffuse tomography more than spatial priors.
abstract: We compare the benefits of spatial and spectral priors in near-infrared diffuse tomography image reconstruction. Although previous studies that incorporated anatomical spatial priors have shown improvement in algorithm convergence and resolution, our results indicate that functional parameter quantification by this approach can be suboptimal. The incorporation of a priori spectral information significantly improves the accuracy observed in recovered images. Specifically, phantom results show that the maximum total hemoglobin concentration ([Hb(T)]) in a region of heterogeneity reached 91% of the true value compared to 63% using spatial priors. The combination of both priors produced results accurate to 98% of the true [Hb(T)]. When both spatial and spectral priors were applied in a healthy volunteer, glandular tissue showed a higher [Hb(T)], water fraction, and scattering power compared to adipose tissue.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA. Ben.A.Brooksby.Th05@Alum.Dartmouth.org
authors.forename: Ben
authors.initials: B
authors.lastname: Brooksby
authors.forename: Subhadra
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Shudong
authors.initials: S
authors.lastname: Jiang
authors.forename: Hamid
authors.initials: H
authors.lastname: Dehghani
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
authors.forename: John
authors.initials: J
authors.lastname: Weaver
authors.forename: Christine
authors.initials: C
authors.lastname: Kogel
authors.forename: Steven P
authors.initials: SP
authors.lastname: Poplack
mesh_terms: D000465:Algorithms; D000818:Animals; D001940:Breast / Q000737:chemistry / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D010100:Oxygen / Q000097:blood*; D019047:Phantoms, Imaging; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*
chemical_list: D006454:Hemoglobins; D010100:Oxygen