[Molecular and genetic characterization of rifampicin- and/or izoniazid-resistent strains of M. tuberculosis, isolated in Novosibirsk and Tomsk regions].
The purpose of the work was to study rifampicin- and izoniazid-resistent strains of M. tuberculosis, circulating in Western Siberia, by VNTR and IS6110 typing. The authors also studied genetic causes of resistance to these antibiotics and undertook a search of new VNTR loci, displaying polymorphism in genomes of closely related clonally-disseminated variants of Mycobacterium tuberculosis in W-Beijing family model analysis.
Tat'kov
S I
SI
Norkina
O V
OV
Filipenko
M L
ML
Sivkov
A Iu
AIu
Boldyrev
A N
AN
Azaev
M Sh
MSh
Kinsht
V N
VN
Kurunov
Iu N
IuN
Krasnov
V A
VA
Medvedeva
E V
EV
Baranova
O I
OI
Ivlev-Duntau
A P
AP
Bodnev
S A
SA
Blinova
L N
LN
Pasechnikov
A D
AD
D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D018598:Minisatellite Repeats / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012294:Rifamycins / Q000494:pharmacology*; D012800:Siberia / Q000453:epidemiology; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
D000995:Antitubercular Agents; D012294:Rifamycins; D007538:Isoniazid