title: The mimetics of antiadhesive peptides as the inhibitors of Mycobacterium kansasii phagocytosis.
abstract: The alpha-guanidino acids derived of 15 proteinaceous amino acids, omega-guanidino acids with gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the mimetics of antiadhesive peptides in Mycobacteria phagocytosis inhibition. The crystal structure of omega-guanidino acids used was determined by X-ray structural analysis. It follows from our experiments that the proper distance between guanidine and carboxyl groups of effector molecules is of decisive importance for their inhibitory activity.
authors.affiliation: Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wroclaw, Poland.
authors.forename: Ignacy Z
authors.initials: IZ
authors.lastname: Siemion
authors.forename: Monika
authors.initials: M
authors.lastname: Gawłowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Slepokura
authors.forename: Monika
authors.initials: M
authors.lastname: Biernat
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Wieczorek
mesh_terms: D000578:Amidines / Q000737:chemistry / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D019791:Guanidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000502:physiology; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D019909:Mycobacterium kansasii; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*
chemical_list: D000578:Amidines; D000596:Amino Acids; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; C004946:glycocyamine; D019791:Guanidine; D005998:Glycine