title: Taurine prevents fructose-diet induced collagen abnormalities in rat skin.
abstract: OBJECTIVE
  The aim of the study is to investigate the effect of taurine administration on the content and characteristics of skin collagen in high-fructose-fed rats.
  
  
  METHODS
  Adult male Wistar rats were divided into four groups of six each: a control group (CON) and a taurine-supplemented control group (CON+TAU), a high fructose diet-fed group (FRU), and a taurine supplemented fructose diet-fed group (FRU+TAU). After 30 days, collagen was isolated from the skin, and its physicochemical properties were studied.
  
  
  RESULTS
  Fructose administration caused an accumulation of collagen and extensive cross-linking. This was evidenced by increases in glycation, fluorescence, and peroxidation in collagen samples. The physicochemical properties of collagen, like shrinkage temperature, aldehyde content, solubility pattern, and susceptibility to denaturing agents, were altered in the fructose-fed rats. The sodium dodecyl sulphate-polyacrylamide gel electrophoretic (SDS-PAGE) pattern of collagen from fructose-fed rats showed and elevated beta component of Type I collagen. Simultaneous administration of taurine alleviated these changes.
  
  
  CONCLUSIONS
  The positive influence of taurine on both collagen content and its properties suggests a potential mechanism for the ability of taurine to delay diabetic complications.
authors.affiliation: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608002, India.
authors.forename: Thirugnanam Anitha
authors.initials: TA
authors.lastname: Nandhini
authors.forename: Velusami
authors.initials: V
authors.lastname: Thirunavukkarasu
authors.forename: Mambakkam Katchapeswaran
authors.initials: MK
authors.lastname: Ravichandran
authors.forename: Carani Venkataraman
authors.initials: CV
authors.lastname: Anuradha
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry / Q000378:metabolism*; D004032:Diet; D005632:Fructose / Q000008:administration & dosage*; D017127:Glycation End Products, Advanced; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012995:Solubility; D013654:Taurine / Q000494:pharmacology*
chemical_list: D017127:Glycation End Products, Advanced; D013654:Taurine; D005632:Fructose; D003094:Collagen