title: Clinical responses to smallpox vaccine in vaccinia-naive and previously vaccinated populations: undiluted and diluted Lancy-Vaxina vaccine in a single-blind, randomized, prospective trial.
abstract: We conducted a single-blind, randomized trial of 2 dilutions (1:1 or 1:10) of Lancy-Vaxina vaccine (Berna Biotech) in vaccinia-naive persons (n=36) and persons previously vaccinated >25 years ago (n=76). All vaccinees responded successfully to the vaccination. There were no significant differences in the size of the skin lesions, the number of adverse events, the amount of viral shedding, or the level of antibody responses between the undiluted (n=56) and diluted (n = 56) vaccine groups. Compared with vaccinia-naive persons, previously vaccinated persons exhibited significantly smaller and more rapidly evolving skin lesions and fewer adverse events. Previously vaccinated persons had significantly higher neutralizing antibody levels before the administration of the study vaccine than vaccinia-naive persons, and viral shedding from lesions in previously vaccinated persons was lower and diminished more rapidly than from lesions in vaccinia-naive persons.
authors.affiliation: Department of Virology, National Institute of Health, Seoul, South Korea.
authors.forename: Sung-Han
authors.initials: SH
authors.lastname: Kim
authors.forename: Sang-Gu
authors.initials: SG
authors.lastname: Yeo
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
authors.forename: Wan-Beom
authors.initials: WB
authors.lastname: Park
authors.forename: Chang-Seop
authors.initials: CS
authors.lastname: Lee
authors.forename: Ki-Deok
authors.initials: KD
authors.lastname: Lee
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Kim
authors.forename: Nam-Joong
authors.initials: NJ
authors.lastname: Kim
authors.forename: Young-Taek
authors.initials: YT
authors.lastname: Kim
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Jee
authors.forename: Haewol
authors.initials: H
authors.lastname: Cho
authors.forename: Myoung-don
authors.initials: MD
authors.lastname: Oh
authors.forename: Kang-Won
authors.initials: KW
authors.lastname: Choe
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D009500:Neutralization Tests; D016037:Single-Blind Method; D012867:Skin / Q000473:pathology; D012900:Smallpox Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D014611:Vaccination; D014616:Vaccinia virus / Q000276:immunology / Q000302:isolation & purification; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D012900:Smallpox Vaccine