title: Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats.
abstract: OBJECTIVE
  Alpha-lipoic acid (ALA) has been used as an antioxidant. The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats.
  
  
  METHODS
  ALA at 1 mg/kg was intra-peritoneally injected, followed by 75 microg/kg CCK-octapeptide injected thrice subcutaneously after 1, 3, and 5 h. This whole procedure was repeated for 5 d. We checked the pancreatic weight/body weight ratio, the secretion of pro-inflammatory cytokines and the levels of lipase, amylase of serum. Repeated CCK octapeptide treatment resulted in typical laboratory and morphological changes of experimentally induced pancreatitis.
  
  
  RESULTS
  ALA significantly decreased the pancreatic weight/body weight ratio and serum amylase and lipase in CCK octapeptide-induced acute pancreatitis. However, the secretion of IL-1beta, IL-6, and TNF-alpha were comparable in CCK octapeptide-induced acute pancreatitis.
  
  
  CONCLUSIONS
  ALA may have a protective effect against CCK octapeptide-induced acute pancreatitis.
authors.affiliation: Department of Microbiology, College of Medicine, Kyung Hee University #1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea.
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Park
authors.forename: Sang-Wan
authors.initials: SW
authors.lastname: Seo
authors.forename: Ok-Sun
authors.initials: OS
authors.lastname: Choi
authors.forename: Cheung-Seog
authors.initials: CS
authors.lastname: Park
mesh_terms: D000208:Acute Disease; D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D006949:Hyperlipidemias / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D010195:Pancreatitis / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D008063:Thioctic Acid; D002766:Cholecystokinin