Anorexia/cachexia-related quality of life for children with cancer.
BACKGROUND
Anorexia is a common symptom in patients with cancer, which can lead to poor tolerance of treatment and can contribute to cachexia in extreme cases. Children with advanced-stage cancer are especially vulnerable to malnutrition resulting from anorexia and cachexia. Currently, there are no instruments that measure common concerns specifically associated with anorexia and cachexia in children with cancer. The purpose of the current article was to test the psychometric properties of a newly developed pediatric Functional Assessment of Anorexia and Cachexia Therapy (peds-FAACT) for children with cancer.


METHODS
Ninety-six patients (ages 7-17 yrs) receiving cancer treatment and their parents were asked to complete the 12-item peds-FAACT. The authors implemented both classical test theory and item response theory to evaluate the agreement between parents and patients, internal consistency and unidimensionality of the scale, and stability of items across subgroups.


RESULTS
As a result, a patient-reported six-item scale was recommended as the core measure for all pediatric patients with cancer and four additional peripheral items were recommended for adolescent patients.


CONCLUSIONS
The peds-FAACT demonstrated good psychometric properties, differentiated patients with different functional performance status, and was determined to be a useful tool for future clinical trials.
Lai
Jin-Shei
JS
Center on Outcomes, Research and Education (CORE), Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA. js-lai@northwestern.edu
Cella
David
D
Peterman
Amy
A
Barocas
Joshua
J
Goldman
Stewart
S
D000293:Adolescent; D017677:Age Distribution; D000855:Anorexia / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D002100:Cachexia / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D011379:Prognosis; D011594:Psychometrics; D011788:Quality of Life; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires