title: Antibody class switch recombination: roles for switch sequences and mismatch repair proteins.
abstract: Mechanisms and targeting of antibody class switch DNA recombination are reviewed. Particular emphasis is on the roles for the DNA sequences comprising switch (S) regions, including the S-region tandem repeats, and on the roles of proteins that are involved in both DNA mismatch repair and in class switch recombination.
authors.affiliation: Genetics Program, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Min
authors.forename: Erik
authors.initials: E
authors.lastname: Selsing
mesh_terms: D000818:Animals; D020137:Base Pair Mismatch; D003564:Cytidine Deaminase / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D017578:Immunoglobulin Class Switching; D007134:Immunoglobulin Switch Region; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D011995:Recombination, Genetic; D020080:Tandem Repeat Sequences; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D004247:DNA; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase