title: Paclitaxel, cisplatin, 5-fluorouracil and radiotherapy in the management of advanced squamous cell carcinoma of the head and neck: a phase II trial.
abstract: Aim of the present study was to test, activity and toxicity of a rapidly alternating chemoradiation (paclitaxel based) in 31 patients with unresectable, locally advanced or recurrent after surgery, head and neck cancer. Three-year overall survival and progression-free survival were 61.4 and 73.7%, respectively. Main side effects remain a major problem.
authors.affiliation: Department of Medical Oncology, S. Croce General Hospital, Cuneo, Italy. mcmerlano@tiscali.it
authors.forename: Marco
authors.initials: M
authors.lastname: Merlano
authors.forename: Elvio G
authors.initials: EG
authors.lastname: Russi
authors.forename: Gianmauro
authors.initials: G
authors.lastname: Numico
authors.forename: Ida
authors.initials: I
authors.lastname: Colantonio
authors.forename: Ornella
authors.initials: O
authors.lastname: Garrone
authors.forename: Antonio
authors.initials: A
authors.lastname: Pelissero
authors.forename: Cristina
authors.initials: C
authors.lastname: Granetto
authors.forename: Milena
authors.initials: M
authors.lastname: Gasco
authors.forename: Gianna
authors.initials: G
authors.lastname: Di Costanzo
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Heouaine
authors.forename: Riccardo
authors.initials: R
authors.lastname: Vigna Taglianti
authors.forename: Marco
authors.initials: M
authors.lastname: Cipolat
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil