Stereoselective synthesis of 3-alkylideneoxindoles via palladium-catalyzed domino reactions.
We have developed efficient catalytic methods for the stereoselective and diversity synthesis of various (E)-, (Z)-, and disubstituted 3-alkylideneoxindoles and 3-alkylidenebenzofuran-2-ones via palladium-catalyzed Heck/Suzuki-Miyaura, Heck/Heck, and Heck/carbonylation/Suzuki-Miyaura domino reactions.
Yanada
Reiko
R
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Obika
Shingo
S
Inokuma
Tsubasa
T
Yanada
Kazuo
K
Yamashita
Masayuki
M
Ohta
Shunsaku
S
Takemoto
Yoshiji
Y
D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D010165:Palladium