title: Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma.
abstract: OBJECTIVE
  To investigate the role of survivin expression in the pathogenesis of colorectal carcinoma.
  
  
  METHODS
  Immunohistochemistry S-P method and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were used to detect the expression of survivin and apoptotic cell in situ in colorectal cancerous tissues, para-cancerous tissues and normal tissues of 48 cases of colorectal carcinoma.
  
  
  RESULTS
  The survivin positive unit (PU) was higher in cancerous tissues (38.76+/-5.14) than in para-cancerous (25.17+/-7.26) or normal tissues (0.57+/-0.03) (P<0.05). The apoptosis index (AI) of para-cancerous tissues was (7.51+/-2.63%) higher than cancerous tissues (4.65+/-1.76%). The expression of survivin was associated with pathological grade, lymph node metastasis and Dukes stage of colorectal carcinoma.
  
  
  CONCLUSIONS
  Survivin expression may play an important role in carcinogenesis of colorectal carcinoma and may be associated with malignant biological behaviors of colorectal carcinoma.
authors.affiliation: Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China. liu9861jun@yahoo.com.cn
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tan
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Shan-Min
authors.initials: SM
authors.lastname: Wu
authors.forename: He-Sheng
authors.initials: HS
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin