Biotransformation of alpha-santonin by cell suspension cultures of five plants.
Cell suspension cultures of five plants (Catharanthus roseus, Ginkgo biloba, Platycodon grandiflorum, Taxus cuspidata, Phytolacca asinosa) were employed to bioconvert the eudesmanolide compound, alpha-santonin. Reactions occurring were hydroxylation (C-1, C-11 and C-15), reduction of the double bond [1(2) or 3(4)], rearrangment of the eudesmanolide skeleton to a guaianolide skeleton and lactone-ring hydrolysis. Four new compounds were identified.
Yang
Lin
L
College of Life and Environmental Sciences, The Central University for Nationalities, 100081, Beijing, P.R. China.
Dai
Jungui
J
Sakai
Junichi
J
Ando
Masayoshi
M
D001711:Biotransformation; D030008:Catharanthus / Q000166:cytology / Q000378:metabolism; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D020441:Ginkgo biloba / Q000166:cytology / Q000378:metabolism; D015394:Molecular Structure; D029603:Phytolacca / Q000166:cytology / Q000378:metabolism; D059828:Plant Cells; D010944:Plants / Q000378:metabolism*; D031238:Platycodon / Q000166:cytology / Q000378:metabolism; D012500:Santonin / Q000737:chemistry / Q000378:metabolism*; D013045:Species Specificity; D020946:Taxus / Q000166:cytology / Q000378:metabolism
D012500:Santonin