Relationships of soluble APO-1 (Fas/CD95) concentrations, obesity, and serum lipid parameters in healthy adults.
To investigate the relationships of apoptosis with obesity and lipid parameters, we measured serum soluble APO-1 (sAPO-1) concentrations, body mass index (BMI), and serum lipid profiles in 176 healthy adults. Serum sAPO-1 levels were measured by enzyme immunoassay. There were no significant differences in mean sAPO-1 concentrations between men and women, nor between subjects with and without obesity. However, women with high-density lipoprotein cholesterol (HDL-C) <50.2 mg/dl exhibited significantly higher sAPO-1 concentrations than those with HDL-C >50.2 mg/dl (ie, 45.6 +/- 10.4 pg/ml vs 31.5 +/- 11.3 pg/ml, p <0.05). Serum sAPO-1 concentrations averaged 46.8 +/- 10.7 pg/ml in women with serum triglyceride >137.4 mg/dl, which was significantly above the mean value (32.6 +/- 12.0 pg/ml, p <0.05) in those with serum triglyceride <137.4 mg/dl. Men with elevated sAPO-1 concentrations showed significantly higher waist-to-hip ratio (WHR) and total body fat (TBF) compared to those with diminished sAPO-1 levels, although no differences were noted in mean values of lipid profiles between the 2 groups of men. Serum sAPO-1 concentrations correlated significantly with HDL-C (r = - 0.41, p <0.05) and triglyceride (r = 0.35, p <0.05) in women and WHR (r = 0.25, p <0.05) and TBF (r = 0.21, p <0.05) in men. In conclusion, serum sAPO-1 appears to have an important relationship to serum lipid levels and body adiposity in healthy adults.
Choi
Jong Weon
JW
Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea. jwchoi@inha.ac.kr
Kim
Soon Ki
SK
D050154:Adiposity; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006262:Health; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D012727:Sex Characteristics; D012995:Solubility; D049629:Waist-Hip Ratio; D019014:fas Receptor / Q000097:blood* / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D019014:fas Receptor