title: MicroRNA gene expression deregulation in human breast cancer.
abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.
authors.affiliation: Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Marilena V
authors.initials: MV
authors.lastname: Iorio
authors.forename: Manuela
authors.initials: M
authors.lastname: Ferracin
authors.forename: Chang-Gong
authors.initials: CG
authors.lastname: Liu
authors.forename: Angelo
authors.initials: A
authors.lastname: Veronese
authors.forename: Riccardo
authors.initials: R
authors.lastname: Spizzo
authors.forename: Silvia
authors.initials: S
authors.lastname: Sabbioni
authors.forename: Eros
authors.initials: E
authors.lastname: Magri
authors.forename: Massimo
authors.initials: M
authors.lastname: Pedriali
authors.forename: Muller
authors.initials: M
authors.lastname: Fabbri
authors.forename: Manuela
authors.initials: M
authors.lastname: Campiglio
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ménard
authors.forename: Juan P
authors.initials: JP
authors.lastname: Palazzo
authors.forename: Anne
authors.initials: A
authors.lastname: Rosenberg
authors.forename: Piero
authors.initials: P
authors.lastname: Musiani
authors.forename: Stefano
authors.initials: S
authors.lastname: Volinia
authors.forename: Italo
authors.initials: I
authors.lastname: Nenci
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
authors.forename: Patrizia
authors.initials: P
authors.lastname: Querzoli
authors.forename: Massimo
authors.initials: M
authors.lastname: Negrini
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Croce
mesh_terms: D015152:Blotting, Northern; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs