Effects of acute administration of methamphetamine on Narp mRNA in rat brain.
Narp (neuronal activity-regulated pentraxin) is a secreted immediate early gene product functioning as a cluster factor for the AMPA receptor subtype of glutamate receptors. This study was designed to examine the effects of acute administration of methamphetamine (MAP) on the Narp gene in rat brain using reverse transcription - polymerase chain reaction (RT-PCR). Acute administration of MAP [4.6 mg/kg, intraperitoneally (i.p.)] increased Narp mRNA in the prefrontal cortex, whereas the same treatment with MAP decreased Narp mRNA in the hippocampus. Therefore, Narp gene could be involved in the MAP-induced effects.
Fukumoto
Makoto
M
Department of Neuropsychiatry, Faculty of Medicine, Tottori Unversity, Tottori, Japan.
Iwata
Masaaki
M
Shinbori
Chiko
C
Hazama
Gen-I
GI
Shirayama
Yukihiko
Y
Kawahara
Ryuzou
R
D000818:Animals; D002097:C-Reactive Protein / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism*; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000099153:Pentraxins
D002097:C-Reactive Protein; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D000099153:Pentraxins