title: Assessment of pulmonary function in COPD.
abstract: Pulmonary function testing is used in the diagnosis of chronic obstructive pulmonary disease (COPD) and the staging of COPD severity. The current diagnostic criterion for airflow obstruction is a ratio of forced expiratory volume in 1 second (FEV (1)) to forced vital capacity (FVC) < 70%. However this absolute definition can lead to false-negative determinations in younger patients and false-positive determinations in the elderly. Nevertheless, screening spirometry is advocated and becomes feasible in the physician office setting with the availability of compact, relatively affordable apparatus that meets the appropriate technical specifications. Spirometry should be complemented by measurement of lung volumes using body plethysmography in those with evidence of airflow obstruction. Small airways disease can be detected by various techniques that measure airway and total respiratory system resistance. There is renewed interest in the forced oscillation technique and impulse oscillometry because of their noninvasiveness and potential ability to distinguish small from larger airway disease. Finally, pulmonary function testing has an important role in preoperative risk assessment; for example, in patients being considered for lung volume reduction surgery or resection of a lung nodule.
authors.affiliation: Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, 10833 Le Conte Avenue, 37-131 CHS, Los Angeles, CA 90095, USA. ccooper@mednet.ucla.edu
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Cooper
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000403:Airway Resistance / Q000187:drug effects; D001993:Bronchodilator Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D012129:Respiratory Function Tests / Q000379:methods*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013147:Spirometry / Q000379:methods
chemical_list: D001993:Bronchodilator Agents