G-protein beta3 subunit C825T polymorphism tends to be associated with seasonal variation in young male college students.
This study investigated the relationship between G-protein beta(3) subunit (GNB3) C825T polymorphism and seasonal variation in 189 young male college students. The subjects were genotyped for C825T and were evaluated by the Seasonality Pattern Assessment Questionnaire. The Global Seasonality Score (GSS) between the three genotypes revealed a marginal difference. The heterozygotes showed significantly higher seasonal variations in GSS than the homozygotes. The prevalence of heterozygotes tended to be higher in seasonals compared with normal subjects, although it was not statistically significant. These results suggest that GNB3 C825T polymorphism tends to be related to seasonal variation in mood and behavior in the normal population.
Lee
Heon-Jeong
HJ
Department of Psychiatry, Anam Hospital, Korea University College of Medicine, Anam-Dong, Seongbuk-Gu, Seoul 136-705, Korea.
Sung
Seung-Mo
SM
Han
Chang-Su
CS
Kim
Yong-Ku
YK
Kim
Seung-Hyun
SH
Lee
Min-Soo
MS
Joe
Sook-Haeng
SH
Jung
In-Kwa
IK
Kim
Leen
L
D000328:Adult; D000339:Affect / Q000502:physiology; D001519:Behavior / Q000502:physiology; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011581:Psychological Tests; D012621:Seasons; D011795:Surveys and Questionnaires
C454420:G-protein beta3 subunit; D004247:DNA; D020962:Heterotrimeric GTP-Binding Proteins