title: [The hypoglycemic effects of crude polysaccharides extract from Momordica charantia in mice].
abstract: OBJECTIVE
  In order to study the hypoglycemic effects of crude polysaccharides extract from Momordica charantia in normal and diabetic mice.
  
  
  METHODS
  Oral glucose tolerance test was carried out in 24 normal mice, CPS was orally administered in experiment group at 1 g/kg BW. 80 diabetic mice (type 1 and type 2 diabetic model) were divided into two groups randomly, CPS was administered at ad lib and fasted condition in experiment group at 1 g/kg BW, blood glucose was measured at different time.
  
  
  RESULTS
  In normal mice, after administered glucose (3g/kgBW) the blood glucose level of experiment group at 0.5, 1 h was significantly lower than that of control group (16.4% and 16.5% lower than control group respectively, P < 0.05 and P < 0.01). In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h, 4h were lower than that of control group (P < 0.05 and P < 0.01 respectively).
  
  
  CONCLUSIONS
  CPS can improve OGTT in normal mice, and has significant hypoglycemic effect in two types diabetic mice.
authors.affiliation: Department of Nutrition, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Zi-Xin
authors.initials: ZX
authors.lastname: Zheng
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Teng
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Liu
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Qiu
authors.forename: Hong
authors.initials: H
authors.lastname: Ouyang
authors.forename: Changyong
authors.initials: C
authors.lastname: Xue
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides