Integrin regulation.
Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified. However, a key unresolved question is how integrins propagate signals across the plasma membrane.
Ginsberg
Mark H
MH
Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.
Partridge
Anthony
A
Shattil
Sanford J
SJ
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism* / Q000502:physiology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010710:Phosphates / Q000378:metabolism; D011487:Protein Conformation; D011494:Protein Kinases / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D016608:Talin / Q000378:metabolism
D016023:Integrins; D010710:Phosphates; D016608:Talin; D011494:Protein Kinases