title: Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea.
abstract: The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
authors.affiliation: Department of Clinical Pathology, The Catholic University of Korea, Medical College, Korea.
authors.forename: Jehoon
authors.initials: J
authors.lastname: Lee
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Kang
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Cho
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Shin
authors.forename: Young Na
authors.initials: YN
authors.lastname: Yum
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Oh
authors.forename: Sheen Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Myung Sil
authors.initials: MS
authors.lastname: Hwang
authors.forename: Chul Joo
authors.initials: CJ
authors.lastname: Lim
authors.forename: Ki Hwa
authors.initials: KH
authors.lastname: Yang
authors.forename: Kyungja
authors.initials: K
authors.lastname: Han
mesh_terms: D000208:Acute Disease; D000230:Adenocarcinoma / Q000821:virology; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007723:Korea; D007938:Leukemia / Q000821:virology*; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000821:virology; D007951:Leukemia, Myeloid / Q000821:virology; D008175:Lung Neoplasms / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000821:virology; D011533:Proviruses / Q000235:genetics*
chemical_list: D004279:DNA, Viral