title: Interest of multifunctional lipid excipients: case of Gelucire 44/14.
abstract: This paper focuses on the interest of a multifunctional lipid excipient from the lauroyl macrogolglycerides, i.e., Gelucire 44/14. This compound, characterized by a drop point of 44 degrees C and a HLB (Hydrophilic Lipophilic Balance) of 14, is made of a specific mixture, leading to particular properties. Gelucire 44/14 forms a fine emulsion in contact with aqueous fluids, inducing a pseudo-solubilization of poorly water-soluble active substances and thus increasing their bioavailability. It could be used either as a binder for immediate release pellets by melt granulation or as a self-emulsifying drug delivery system by capsule molding or as a powder obtained by cryogenic grinding. These different methods and their interests are then discussed.
authors.affiliation: Groupe Technologie des Poudres à Usage Pharmaceutique, Equipe IMSAPS, EA 581, UFR Pharmacie, France. odile.chambin@u-bourgogne.fr
authors.forename: O
authors.initials: O
authors.lastname: Chambin
authors.forename: V
authors.initials: V
authors.lastname: Jannin
mesh_terms: D000082:Acetaminophen / Q000737:chemistry / Q000493:pharmacokinetics; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D005079:Excipients / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D018712:Analgesics, Non-Narcotic; D002214:Capsules; D003692:Delayed-Action Preparations; D005079:Excipients; D008055:Lipids; C104509:gelucire 44-14; D000082:Acetaminophen; D011092:Polyethylene Glycols