title: Acid normalization and improved esophageal motility after Nissen fundoplication: equivalent outcomes in patients with normal and ineffective esophageal motility.
abstract: BACKGROUND
  Severe gastroesophageal reflux disease may result in acquired esophageal dysmotility. The correct surgical approach to associated gastroesophageal reflux disease and dysmotility is controversial, in particular whether the "gold-standard" total fundoplication of Nissen is appropriate compared with partial fundoplication. Our unit has performed total fundoplication for all patients, irrespective of esophageal motility, and this article describes that experience.
  
  
  METHODS
  Ninety-eight patients undergoing antireflux surgery were divided into 2 groups. Group 1 (n=60) consisted of patients with normal esophageal motility, and group 2 (n=38) had dysmotility. All patients underwent preoperative and postoperative manometry, 24-hour pH testing, symptom scoring, and quality-of-life assessment.
  
  
  RESULTS
  The median postoperative acid score was not significantly different between groups 1 and 2. Eighty-eight percent of patients with normal motility and 89% of patients with dysmotility had no symptoms or minor symptoms, with a significant improvement in quality of life 6 months after surgery. There was a significant increase in esophageal wave amplitude in both groups, and 20 patients (53%) in the dysmotility group reverted to normal motility after surgery. Recurrent symptoms were associated with postoperative abnormal pH profiles in 5 patients from group 1 and 3 from group 2.
  
  
  CONCLUSIONS
  Preoperative dysmotility is not a contraindication for total fundoplication. Postoperative acid control is associated with improved esophageal clearance and symptoms.
authors.affiliation: University Department of Surgery, St James' Hospital, Dublin 8, Ireland.
authors.forename: Narayanasamy
authors.initials: N
authors.lastname: Ravi
authors.forename: Nael
authors.initials: N
authors.lastname: Al-Sarraf
authors.forename: Tracey
authors.initials: T
authors.lastname: Moran
authors.forename: James
authors.initials: J
authors.lastname: O'Riordan
authors.forename: Suzanne
authors.initials: S
authors.lastname: Rowley
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Byrne
authors.forename: John V
authors.initials: JV
authors.lastname: Reynolds
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015154:Esophageal Motility Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome