Selective targeting of DNA for cleavage within DNA-histone assemblies by a spermine-[CpW(CO)3Ph]2 conjugate.
In contrast to the histone-modifying action of other complexes of the type CpML(n)R, the compound obtained by linking the phenyl rings of two CpW(CO)(3)Ph moieties to the DNA-binding agent spermine selectively cleaves DNA in DNA-histone assemblies.
Shell
Thomas A
TA
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA.
Mohler
Debra L
DL
D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D004249:DNA Damage; D005609:Free Radicals / Q000737:chemistry; D006657:Histones / Q000737:chemistry* / Q000528:radiation effects; D008027:Light; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000528:radiation effects; D010777:Photochemistry; D013096:Spermine / Q000737:chemistry* / Q000528:radiation effects; D014414:Tungsten / Q000737:chemistry* / Q000528:radiation effects
D005609:Free Radicals; D006657:Histones; D009942:Organometallic Compounds; D013096:Spermine; D004247:DNA; D014414:Tungsten