title: An improved synthesis of Fmoc-N-methyl-alpha-amino acids.
abstract: A highly efficient and environmentally more benign synthesis of Fmoc-N-methyl-alpha-amino acids from the corresponding Fmoc-amino acid, via intermediate 5-oxazolidinones, has been developed by using Lewis acid catalysis for the reductive opening of the oxazolidinone ring.
authors.affiliation: Department of Chemistry, Organic Chemistry, Uppsala University Box 599, SE-751 24 Uppsala, Sweden.
authors.forename: Suode
authors.initials: S
authors.lastname: Zhang
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.forename: Thomas
authors.initials: T
authors.lastname: Norström
authors.forename: Per I
authors.initials: PI
authors.lastname: Arvidsson
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D005449:Fluorenes / Q000737:chemistry*; D008027:Light; D013058:Mass Spectrometry; D012542:Scattering, Radiation; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000596:Amino Acids; D005449:Fluorenes