title: Effect of ethanol and thermally oxidized sunflower oil ingestion on phospholipid fatty acid composition of rat liver: protective role of Cuminum cyminum L.
abstract: OBJECTIVE
  The current study was undertaken to assess the effect of ethanol and thermally oxidized sunflower oil ingestion on liver phospholipid fatty acids and the protective role of Cuminum cyminum L.
  
  
  METHODS
  Ethanol was administered at a level of 20% and thermally oxidized sunflower oil at a level of 15% for 45 days. C. cyminum was administered at a dosage of 250 mg/kg body weight for 45 days. We investigated the changes in the liver phospholipid fatty acid composition.
  
  
  RESULTS
  Ethanol and thermally oxidized sunflower oil administration modifies the fatty acid composition and the analysis of fatty acids showed that there was a significant increase in the concentrations of 16:0, 16:1, 18:0, 18:1 and 18:2, whereas the concentration of 20:4 was significantly decreased. The concentrations of 16:0, 16:1, 18:0, 18:1 and 20:4 were near normal in cumin-treated rats.
  
  
  CONCLUSIONS
  The present investigation shows that cumin prevents the changes in the composition of fatty acids, which were produced by ethanol and thermally oxidized oil.
authors.affiliation: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
authors.forename: Aruna
authors.initials: A
authors.lastname: Kode
authors.forename: Rukkumani
authors.initials: R
authors.lastname: Rajagopalan
authors.forename: Suresh Varma
authors.initials: SV
authors.lastname: Penumathsa
authors.forename: Venugopal P
authors.initials: VP
authors.lastname: Menon
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D028527:Cuminum / Q000737:chemistry*; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D008099:Liver / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils / Q000378:metabolism / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000074242:Sunflower Oil
chemical_list: D005227:Fatty Acids; D010743:Phospholipids; D010936:Plant Extracts; D010938:Plant Oils; D000074242:Sunflower Oil; D000431:Ethanol