title: Study of the labeling of two novel RGD-peptidic derivatives with the precursor [99mTc(H2O)3(CO)3]+ and evaluation for early angiogenesis detection in cancer.
abstract: In the initial stages of tumor formation, overexpression of integrins identifying the RGD sequence (Arg-Gly-Asp) is observed. The aim of the present study was the synthesis and labeling of two novel RGD derivatives, via the precursor [99mTc(H2O)3(CO)3]+, as well as the radiochemical and radiopharmacological evaluation of the labeled products. The labeling led to the formation of a single product in each case (>98%), with noteworthy in vitro stability, fast blood clearance and elimination by the hepatobiliary and the urinary systems.
authors.affiliation: Biomedica Life Sciences S.A., Athens, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Psimadas
authors.forename: M
authors.initials: M
authors.lastname: Fani
authors.forename: C
authors.initials: C
authors.lastname: Zikos
authors.forename: S
authors.initials: S
authors.lastname: Xanthopoulos
authors.forename: S C
authors.initials: SC
authors.lastname: Archimandritis
authors.forename: A D
authors.initials: AD
authors.lastname: Varvarigou
mesh_terms: D000818:Animals; D005260:Female; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000378:metabolism; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D017556:Technetium Compounds; C047981:arginyl-glycyl-aspartic acid