Lower brain-derived neurotrophic factor in serum of relapsing remitting MS: reversal by glatiramer acetate.
Neuronal growth factors may exert a neuroprotective effect in multiple sclerosis (MS). We found reduced levels of brain-derived neurotrophic factors (BDNF) in the serum and CSF of relapsing-remitting MS patients, which was reversed by therapy with glatiramer acetate. BDNF may play a protective role in MS, and immunomodulation therapy, such as with glatiramer acetate, may enhance the action this mechanism.
Azoulay
David
D
Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
Vachapova
Veronika
V
Shihman
Boris
B
Miler
Ariel
A
Karni
Arnon
A
D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use*
D019208:Brain-Derived Neurotrophic Factor; D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate