Successful pregnancy in a 45-year-old woman with elevated day 3 serum follicle stimulating hormone and a short follicular phase.
OBJECTIVE
To determine if a successful pregnancy is possible in a woman aged 45 with elevated day 3 serum follicle stimulating hormone (FSH), a short follicular phase, and failure to attain a mature follicle before ovulating.


METHODS
Ethinyl/estradiol (20 microg daily) was given from day 2 of the menstrual cycle until follicular maturation was attained. Progesterone support of 200 mg twice daily progesterone vaginal suppositories were given in the luteal phase.


RESULTS
A mature follicle was attained on day 12 with a serum estradiol of 335 pg/ml. Successful pregnancy and delivery were attained.


CONCLUSIONS
This is the third reported case of a successful pregnancy in a woman > or = 45 years old with hypergonadotropism, and the first one reported that was also complicated by a short follicular phase.
Katsoff
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, NJ, USA.
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D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007273:Injections, Intramuscular; D008183:Luteal Phase / Q000187:drug effects; D008875:Middle Aged; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011374:Progesterone / Q000008:administration & dosage*; D013488:Suppositories
D013488:Suppositories; D004997:Ethinyl Estradiol; D011374:Progesterone; D005640:Follicle Stimulating Hormone