Role of the AZFd locus in spermatogenesis.
To determine the prevalence of Y-chromosome microdeletions among infertile men and to correlate the clinical presentation of the men with specific deletions, microdeletion analysis in 53 infertile men (30 nonobstructive azoospermic, 23 severely oligozoospermic patients), and 100 age-matched, fathered normospermic men who had fathered children was performed by the multiplex PCR with 18 different Y-chromosome-specific STS primer sets, spanning the AZFa, AZFb, AZFd, and AZFc regions. Detection of the same locus deletion of the AZFd region in three cases indicated the possible importance of the genes located in this region in spermatogenesis.
Müslümanoglu
Muhammed Hamza
MH
Department of Medical Genetics, Osmangazi University Medical Faculty, Meşelik, Eskişehir, Turkey.
Turgut
Mehmet
M
Cilingir
Oguz
O
Can
Cavit
C
Ozyürek
Yusuf
Y
Artan
Sevilhan
S
D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D056426:Genetic Loci; D005819:Genetic Markers / Q000502:physiology; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000453:epidemiology / Q000235:genetics; D015995:Prevalence; D029589:Seminal Plasma Proteins / Q000235:genetics / Q000502:physiology*; D013091:Spermatogenesis / Q000235:genetics*
D005819:Genetic Markers; D029589:Seminal Plasma Proteins