title: Doppler ultrasound assessment and serum cancer antigen 125 in the diagnosis of ovarian tumors.
abstract: OBJECTIVE
  To differentiate benign from malignant ovarian tumors based on sonographic detection of a solid component.
  
  
  METHODS
  Sixty-three women with ovarian masses were evaluated preoperatively by gray scale and power/color Doppler ultrasonographic examination, with specific predefined criteria for the solid component. Sensitivity, specificity, and positive and negative predictive values were calculated and assessed against the histopathologic outcome. The contribution of cancer antigen (CA) 125 levels to the diagnostic accuracy was also assessed.
  
  
  RESULTS
  Sensitivity, specificity, and positive and negative predictive values were 100%, 95.2%, 91.3% and 100%, respectively, with two false-positive results. Had an elevated CA 125 level (>35 U/mL) been included in the malignancy criteria, the false-positive results would have been eliminated, giving an accuracy of 100%.
  
  
  CONCLUSIONS
  Sonographic evaluation with predefined specific criteria for the detection of a solid tumor component is an accurate method of preoperative discrimination between benign and malignant ovarian tumors. A serum CA 125 assay may assist in eliminating false-positive results.
authors.affiliation: Erciyes University, Department of Radiology, Kayseri, Turkey. nerdogan@erciyes.edu.tr
authors.forename: N
authors.initials: N
authors.lastname: Erdoğan
authors.forename: B
authors.initials: B
authors.lastname: Ozçelik
authors.forename: I S
authors.initials: IS
authors.lastname: Serin
authors.forename: M
authors.initials: M
authors.lastname: Akgün
authors.forename: F
authors.initials: F
authors.lastname: Oztürk
mesh_terms: D000291:Adnexal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000097:blood*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011300:Preoperative Care; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000592:standards
chemical_list: D018394:CA-125 Antigen