title: Interstitial Doppler optical coherence tomography.
abstract: Doppler optical coherence tomography (OCT) can image tissue structure and blood flow at micrometer-scale resolution but has limited imaging depth. We report a novel, linear-scanning, needle-based Doppler OCT system using angle-polished gradient-index or ball-lensed fibers. A prototype system with a 19-guage (diameter of approximately 0.9 mm) echogenic needle is constructed and demonstrates in vivo imaging of bidirectional blood flow in rat leg and abdominal cavity. To our knowledge, this is the first demonstration of Doppler OCT through a needle probe in interstitial applications to visualize deeply situated microcirculation.
authors.affiliation: University Health Network, Toronto, Ontario, Canada. victor.yang@utoronto.ca
authors.forename: Victor X D
authors.initials: VX
authors.lastname: Yang
authors.forename: You X
authors.initials: YX
authors.lastname: Mao
authors.forename: Nigel
authors.initials: N
authors.lastname: Munce
authors.forename: Beau
authors.initials: B
authors.lastname: Standish
authors.forename: Walter
authors.initials: W
authors.lastname: Kucharczyk
authors.forename: Norman E
authors.initials: NE
authors.lastname: Marcon
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
authors.forename: I Alex
authors.initials: IA
authors.lastname: Vitkin
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D015150:Echocardiography, Doppler / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D007089:Image Enhancement / Q000295:instrumentation*; D008833:Microcirculation / Q000000981:diagnostic imaging* / Q000502:physiology*; D051381:Rats; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D018084:Ultrasonography, Interventional / Q000295:instrumentation* / Q000379:methods