title: Statistical analysis of the DIAMOND MI study by the multipole method.
abstract: We present a new method to describe the dynamics of the beat-to-beat RR time series. The classification of the phase-space plots obtained from RR time series is performed by a calculation of parameters which describe the features of the two-dimensional plot. We demonstrate that every parameter has its specific consequence on the evaluation of the state of the cardiac function. By applying the method to the DIAMOND MI study we demonstrate that these parameters have more prognostic power than previously suggested risk markers. The results suggest that the RR intervals constitute a highly complex time series which necessitates the use of refined mathematical-statistical methods in order to reveal pathologies in the heart rate.
authors.affiliation: Department of Cardiology, Amtssygehuset i Gentofte, Copenhagen University Hospital, Denmark.
authors.forename: R M
authors.initials: RM
authors.lastname: Olesen
authors.forename: P E Bloch
authors.initials: PE
authors.lastname: Thomsen
authors.forename: K
authors.initials: K
authors.lastname: Saermark
authors.forename: M
authors.initials: M
authors.lastname: Glikson
authors.forename: S
authors.initials: S
authors.lastname: Feldman
authors.forename: M
authors.initials: M
authors.lastname: Lewkowicz
authors.forename: J
authors.initials: J
authors.lastname: Levitan
mesh_terms: D004311:Double-Blind Method; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D010627:Phenethylamines / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D013223:Statistics as Topic; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D010627:Phenethylamines; D013449:Sulfonamides; C063533:dofetilide