The functional neuroanatomy of coordinated orofacial movements: sparse sampling fMRI of whistling.
Whistling serves as a model for a skilful coordinated orofacial movement with sensorimotor integration of auditory and proprioceptive input. The neural substrate of whistling was investigated by sparse sampling functional MRI (fMRI) where the motor task occurred during a silent interval between successive image acquisitions to minimize task-related imaging artefacts. Whistling recruited a symmetrically represented neural network including primary motor and ventral premotor cortex (PMv), SMA, cingulate gyrus, basal ganglia, primary and secondary somatosensory cortex, amygdala, thalamus and cerebellum. A temporal analysis revealed higher activity of left sensory cortex, right PMv and cerebellum during late execution compared to initiation of whistling. Task-related signal changes in right PMv and right paravermal cerebellum were found to correlate with the amplitude of the whistle sound in a separate correlation analysis. The findings emphasize the role of ventral premotor cortex, cerebellum and somatosensory areas as integrators of afferent input within a distributed orofacial sensorimotor network.
Dresel
Christian
C
Department of Neurology, Klinikum rechts der Isar, Technische Universitaet Muenchen, Moehlstrasse 28, D-81675 Munich, Germany. dresel@lrz.tu-muenchen.de
Castrop
Florian
F
Haslinger
Bernhard
B
Wohlschlaeger
Afra M
AM
Hennenlotter
Andreas
A
Ceballos-Baumann
Andres O
AO
D000328:Adult; D000368:Aged; D001921:Brain / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D003627:Data Interpretation, Statistical; D005145:Face / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008046:Lip / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D009055:Mouth / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011930:Reaction Time / Q000502:physiology; D012119:Respiration; D013003:Somatosensory Cortex / Q000502:physiology
D010100:Oxygen