[Study of antiradical activity of new compounds by chemiluminescence].
Antioxidative and antiradical properties of a new antioxidant cerebroprotective drug, enoxifol (benzimidasole derivative), were compared with mexidol by means of three chemiluminescent techniques: luminol autooxidation system, Fe2+-induced lipid chemiluminescence and lucigenin-induced chemiluminescence with superoxide generation by xanthine-xanthine oxidase system. Enoxifol exhibited higher antiradical activity than mexidol. This was shown by suppression of luminol radicals and superoxide anion-radical generation. Antioxidant properties of enoxifol were also demonstrated by decreasing of Fe2+-induced lipid chemiluminescence. The recognized properties of enoxifol influencing chemiluminescent processes confirm the results, obtained earlier by means of indirect methods of free radical processes study in vitro and in vivo (decrease of LPO products, activation of antioxidant enzymes), also can underline its pharmacological effects.
Kosolapov
V A
VA
Spasov
A A
AA
Anisimova
V A
VA
D000166:Acridines / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry*; D001562:Benzimidazoles / Q000737:chemistry*; D002951:Citrates / Q000737:chemistry; D019343:Citric Acid; D005296:Ferrous Compounds / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D008163:Luminescent Measurements; D008165:Luminol / Q000737:chemistry; D018696:Neuroprotective Agents / Q000737:chemistry*; D010084:Oxidation-Reduction; D010847:Picolines / Q000737:chemistry; D000077559:Sodium Citrate; D019820:Xanthine / Q000737:chemistry; D014969:Xanthine Oxidase / Q000737:chemistry
D000166:Acridines; D000975:Antioxidants; D001562:Benzimidazoles; D002951:Citrates; D005296:Ferrous Compounds; D005609:Free Radicals; D018696:Neuroprotective Agents; D010847:Picolines; D019820:Xanthine; D000077559:Sodium Citrate; C033472:10,10'-dimethyl-9,9'-biacridinium; D019343:Citric Acid; C070020:emoxypine succinate; C016600:ferrous citrate; D008165:Luminol; D014969:Xanthine Oxidase