title: Dose response modelling of Escherichia coli O157 incorporating data from foodborne and environmental outbreaks.
abstract: A human dose response model for Escherichia coli O157 would enable prediction of risk of infection to humans following exposure from either foodborne or environmental pathways. However, due to the severe nature of the disease, volunteer human dose response studies cannot be carried out. Surrogate models from Shigella fed to humans and E. coli O157 to rabbits have been utilised but are significantly different to one another. In addition data obtained by animal exposure may not be representative for human beings. An alternative approach to generating and validating a dose response model is to use quantitative data obtained from actual human outbreaks. This work collates outbreak data obtained from global sources and these are fitted using exponential and beta-Poisson models. The best fitting model was found to be the beta-Poisson model using a beta-binomial likelihood and the authors favour the exact version of this model. The confidence levels in this model encompass a previously published Shigella dose response model. The potential incorporation of this model into QMRAs is discussed together with applications of the model to help explain foodborne outbreaks.
authors.affiliation: School of Biological Sciences, University of Aberdeen, Cruickshank Building, Aberdeen, AB24 3UU, UK. n.strachan@abdn.ac.uk
authors.forename: Norval J C
authors.initials: NJ
authors.lastname: Strachan
authors.forename: Michael P
authors.initials: MP
authors.lastname: Doyle
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kasuga
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Rotariu
authors.forename: Iain D
authors.initials: ID
authors.lastname: Ogden
mesh_terms: D000818:Animals; D015169:Colony Count, Microbial / Q000379:methods*; D004195:Disease Models, Animal; D004196:Disease Outbreaks; D004927:Escherichia coli Infections / Q000453:epidemiology*; D019453:Escherichia coli O157 / Q000254:growth & development*; D006801:Humans; D015233:Models, Statistical; D011817:Rabbits; D012307:Risk Factors