Cell migration in 3D matrix.
The ability of cells to migrate within the extracellular matrix and to remodel it depends as much on the physical and biochemical characteristics of a particular matrix as on cellular properties. Analyzing the different modes of migration of cells in matrices, and how cells switch between these modes, is vital for understanding a variety of physiological and pathological processes. Recent work provides new insights, but also raises some debates about the mechanisms and regulation of cell migration in three-dimensional matrices.
Even-Ram
Sharona
S
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892-4370, USA. sram@dir.nidcr.nih.gov
Yamada
Kenneth M
KM
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D020559:Monomeric GTP-Binding Proteins