Obese subjects with heart failure have lower N-terminal pro-brain natriuretic peptide plasma levels irrespective of aetiology.
N-terminal pro-brain natriuretic peptide (NT-proBNP) may be useful in the diagnosis of heart failure and ventricular dysfunction. Obesity is an independent cardiovascular risk factor. The purpose of this study was to measure NT-proBNP plasma levels in obese and non-obese subjects with heart failure and to compare levels in subjects with ischaemic and dilated aetiology. In this study, obese subjects had 63% lower NT-proBNP plasma levels than non-obese subjects (p < 0.01). In multivariate analysis, BMI was inversely associated with NT-proBNP plasma levels (p < 0.05) and a 17% decrease in natriuretic peptide levels was attributed to obesity (p < 0.036). When we analyzed data according to the aetiology of heart failure, we found that both groups (ischaemic and dilated) had a 65% decrease in NT-proBNP plasma levels in obese subjects compared to non-obese subjects.
Rivera
Miguel
M
Department of Cardiology, Research Center La Fe Hospital, José María Haro, Valencia, Spain. rivera_jmi@gva.es
Cortés
Raquel
R
Salvador
Antonio
A
Bertomeu
Vicente
V
de Burgos
Fernando García
FG
Payá
Rafael
R
Portolés
Manuel
M
Taléns-Visconti
Raquel
R
Martinez-Dolz
Luis
L
Valero
Ricardo
R
Sevilla
Begoña
B
Climent
Vicente
V
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000150:complications*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain