title: Recombinant activated factor VII as an adjunct to packing for liver injury with hepatic venous disruption.
abstract: Injuries to the juxtahepatic veins represent a small proportion of all liver injuries but constitute the most challenging and deadly form of hepatic trauma. Recombinant activated factor VII, established as a crucial therapy for enhancing hemostasis in hemophiliacs with inhibitors, has also been used to correct coagulopathy after traumatic injury. We report two children with hepatic venous injury requiring perihepatic packing and recombinant activated factor VII to successfully control hemorrhage.
authors.affiliation: Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA.
authors.forename: Joachim
authors.initials: J
authors.lastname: Chino
authors.forename: David
authors.initials: D
authors.lastname: Paolini
authors.forename: Anh
authors.initials: A
authors.lastname: Tran
authors.forename: Prasad
authors.initials: P
authors.lastname: Mathew
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Howdieshell
mesh_terms: D000063:Accidents, Traffic; D002648:Child; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006465:Hemoperitoneum / Q000175:diagnosis / Q000628:therapy*; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D015601:Injury Severity Score; D007813:Laparotomy / Q000379:methods; D008099:Liver / Q000293:injuries*; D008107:Liver Diseases / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015942:Factor VIIa