Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.
Hamzah
H G
HG
Pierce
A
A
Stewart
W A
WA
Peter Downes
C
C
Gray
A
A
Irvine
A
A
Spooncer
E
E
Whetton
A D
AD
D018952:Antigens, CD34 / Q000378:metabolism*; D001549:Benzamides; D002630:Chemotactic Factors / Q000494:pharmacology*; D016207:Cytokines / Q000494:pharmacology*; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
D018952:Antigens, CD34; D001549:Benzamides; D002630:Chemotactic Factors; D016207:Cytokines; D018129:Phosphatidylinositol Phosphates; D010879:Piperazines; D011743:Pyrimidines; C060974:phosphatidylinositol 3,4,5-triphosphate; D000068877:Imatinib Mesylate