Immunodetection of the signal transducer and activator of transcription-3 in canine haemangioma and haemangiosarcoma.
The aim of this study was to examine the expression of signal transducer and activator of transcription 3 (STAT3) in canine haemangiomas and haemangiosarcomas. STAT3 protein was demonstrated in both the cytoplasm and nuclei of labelled cells. The expression of STAT3 was observed in 87.50% (35/40) of both haemangiomas and haemangiosarcomas and 72.22% (13/18) of haemangiomas and 100% (22/22) haemangiosarcomas. The percentage of positive cells in haemangiomas and haemangiosarcomas was statistically significant difference (P<0.0001). These preliminary results indicate that STAT3 is overexpressed in malignant tumours.
Petterino
Claudio
C
Department of Public Health, School of Veterinary Medicine, University of Padua, Strada Romea 16, Agripolis, Legnaro (PD), Italy. claudio.petterino@unipd.it
Rossetti
Enrica
E
Drigo
Michele
M
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D015972:Gene Expression Regulation, Neoplastic; D006391:Hemangioma / Q000378:metabolism* / Q000662:veterinary*; D006394:Hemangiosarcoma / Q000378:metabolism* / Q000662:veterinary*; D007150:Immunohistochemistry; D050796:STAT3 Transcription Factor / Q000032:analysis* / Q000276:immunology*
D050796:STAT3 Transcription Factor