Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2).
Keratinocyte growth factor-2 (KGF-2) is found in dermal papilla fibroblasts and its receptor, fibroblast growth factor receptor 2 (FGFR2), in the neighboring outer root sheath of keratinocytes. Administration of recombinant human KGF-2 (rhKGF-2) at 10 ng ml(-1) significantly stimulated human hair-follicle cell proliferation in organ culture (26-35%). Thus, rhKGF-2 is a promising therapeutic agent to stimulate human hair growth.
Jang
Jun-Hyeog
JH
Department of Biochemistry, Inha University College of Medicine, Incheon 400-712, Korea. juhjang@inha.ac.kr
D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000235:genetics; D051526:Fibroblast Growth Factor 10 / Q000235:genetics / Q000494:pharmacology*; D018859:Hair Follicle / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
C496463:FGF10 protein, human; D051526:Fibroblast Growth Factor 10; D011994:Recombinant Proteins