Loading and release of charged dyes using ultrathin hydrogels.
The anionic dyes methyl orange (MO) and allura red (AR) were used as model drugs to assess the loading and release by layer-by-layer assembled ultrathin hydrogels prepared via the amide formation of poly(acrylic acid-co-N-isopropylacrylamide) with AAc contents of 5, 10, and 15 mol % plus poly(vinylamine hydrochloride). The amount of MO loaded was potentially controlled by changing the dye concentrations, film thickness, and AAc content of the copolymers. The release of AR was controlled by the NaCl concentration and pH. We conclude that the polymeric matrices of ultrathin hydrogels have great potential for the loading and release of charged drugs.
Serizawa
Takeshi
T
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.
Matsukuma
Daisuke
D
Akashi
Mitsuru
M
D000178:Acrylamides / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D000838:Anions / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry*; D004396:Coloring Agents / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008567:Membranes, Artificial; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors
D000178:Acrylamides; D000179:Acrylates; D000577:Amides; D000838:Anions; D001391:Azo Compounds; D004396:Coloring Agents; D020100:Hydrogels; D008567:Membranes, Artificial; C090629:N-isopropylacrylamide-acrylic acid copolymer; D011108:Polymers; D011145:Polyvinyls; C005915:Allura Red AC Dye; C008996:poly(vinylamine); C100258:methyl orange