[Selection of the receptor fluid based on main drug' s dissolvability in the in-vitro skin permeation study].
OBJECTIVE
To select the receptor fluid used in the in-vitro skin permeation study of CVD from Shuxin transdermal patch.


METHODS
The saturated concentration of CVD in different receptor fluid was determined by RP-HPLC with precolumn ultraviolet derivatization. And the selection of receptor fluid was based on main drug's dissolvability.


RESULTS
The concentration of CVD in 30% ethanol/physiological saline was the highest among seven kinds of receptor fluid.


CONCLUSIONS
The method used to select the receptor fluid based on main drug's dissolvability in the in-vitro skin permeation study is credible and convenient.
Wei
Min
M
Guangzhou University of TCM, Guangzhou 510405.
Zhou
Liling
L
Huang
Chunqing
C
Jiang
Yingying
Y
D000279:Administration, Cutaneous; D000470:Alkaloids / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D000431:Ethanol; D066298:In Vitro Techniques; D010539:Permeability; D010946:Plants, Medicinal / Q000737:chemistry*; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012965:Sodium Chloride; D012995:Solubility; D012997:Solvents / Q000493:pharmacokinetics*
D000470:Alkaloids; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D012997:Solvents; D000431:Ethanol; D012965:Sodium Chloride