title: Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.
abstract: Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 microM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 microM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.
authors.affiliation: School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0666, USA.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Mosel
authors.forename: Raluca
authors.initials: R
authors.lastname: Dumitru
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Hornby
authors.forename: Audrey L
authors.initials: AL
authors.lastname: Atkin
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Nickerson
mesh_terms: D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005204:Farnesol / Q000494:pharmacology*; D007700:Kinetics; D044967:Serum / Q000378:metabolism*
chemical_list: D003470:Culture Media; D005204:Farnesol