Humoral immunity in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.
Abnormal immunoglobulin synthesis within the central nervous system is a common finding in patients with multiple sclerosis (MS) that is often used for diagnosis. However, it is not clear whether antibodies, or the B-cells and plasma cells that make them, are critical to the pathogenesis of MS. Here we review the descriptive data that suggest a role for antibody in the pathogenesis of MS. The results of B-cell and antibody depletion studies in the animal model for MS, experimental autoimmune encephalomyelitis, are summarized, as well as early data using a chimeric monoclonal antibody to deplete B-cells in patients with MS.
Cross
Anne H
AH
Department of Neurology & Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA. crossa@neuro.wustl.edu
Stark
Jennifer L
JL
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000936:Antigen-Antibody Complex / Q000378:metabolism; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001323:Autoantibodies / Q000096:biosynthesis* / Q000134:cerebrospinal fluid / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology; D003165:Complement System Proteins / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008212:Lymphocyte Depletion; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy; D004676:Myelin Basic Protein / Q000276:immunology; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein; D051381:Rats
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000961:Antilymphocyte Serum; D001323:Autoantibodies; C571326:MOG protein, human; C571327:Mog protein, mouse; C571328:Mog protein, rat; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D003165:Complement System Proteins