title: Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats.
abstract: The aging process is associated with cognitive impairment and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, as well as with oxidative stress. We determined some parameters of oxidative stress in homogenates of hippocampus, hypothalamus and adrenal glands from male 2-, 6- and 24-months-old Wistar rats. A significant age-dependent increase in the generation of free radicals was observed in hippocampus, hypothalamus and adrenal glands, as well as on lipid peroxidation in hippocampus and hypothalamus. The glutathione peroxidase (GPx) activity was significantly reduced in hypothalamus and hippocampus from 6-months-old rats; a decline on GPx and catalase activities in adrenal glands of 24-months-old animals was also present. Interestingly, a great decrease in total antioxidant capacity was found in all tissues tested. Reported findings support the idea that oxidative events participate on multiple neuroendocrine-metabolic impairments and suggest that the oxidative stress found in hippocampus, hypothalamus and adrenals might be associated with age-related physiological deficits.
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas-Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. ionara@ufrgs.br
authors.forename: Ionara
authors.initials: I
authors.lastname: Rodrigues Siqueira
authors.forename: Cíntia
authors.initials: C
authors.lastname: Fochesatto
authors.forename: Iraci Lucena
authors.initials: IL
authors.lastname: da Silva Torres
authors.forename: Carla
authors.initials: C
authors.lastname: Dalmaz
authors.forename: Carlos
authors.initials: C
authors.lastname: Alexandre Netto
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D050050:Protein Carbonylation / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D005609:Free Radicals