title: Therapeutic targets in Paracoccidioides brasiliensis: post-transcriptome perspectives.
abstract: The rise in antifungal resistance, observed as a result of the increasing numbers of immunocompromised patients, has made the discovery of new targets for drug therapy imperative. The description of the Paracoccidioides brasiliensis transcriptome has allowed us to find alternatives to refine current therapy against paracoccidioidomycosis. We used comparative analysis of expressed sequence tags to find promising drug targets that have been addressed in other pathogens. We divided the analysis into six different categories, based on the involvement of the targeted mechanisms in the cell: i) cell wall construction, ii) plasma membrane composition, iii) cellular machinery, iv) cellular metabolism, v) signaling pathways, and vi) other essential processes. Through this approach, it has been possible to infer strategies to develop alternative drugs against this pathogen.
authors.affiliation: Departamento de Biologia Celular, IB, Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: André Corrêa
authors.initials: AC
authors.lastname: Amaral
authors.forename: Larissa
authors.initials: L
authors.lastname: Fernandes
authors.forename: Alexsandro Sobreira
authors.initials: AS
authors.lastname: Galdino
authors.forename: Maria Sueli Soares
authors.initials: MS
authors.lastname: Felipe
authors.forename: Célia Maria de Almeida
authors.initials: CM
authors.lastname: Soares
authors.forename: Maristela
authors.initials: M
authors.lastname: Pereira
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D015195:Drug Design; D020224:Expressed Sequence Tags; D006801:Humans; D010228:Paracoccidioides / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D000935:Antifungal Agents