Tools and strategies for physiological genomics: the Rat Genome Database.
The broad goal of physiological genomics research is to link genes to their functions using appropriate experimental and computational techniques. Modern genomics experiments enable the generation of vast quantities of data, and interpretation of this data requires the integration of information derived from many diverse sources. Computational biology and bioinformatics offer the ability to manage and channel this information torrent. The Rat Genome Database (RGD; http://rgd.mcw.edu) has developed computational tools and strategies specifically supporting the goal of linking genes to their functional roles in rat and, using comparative genomics, to human and mouse. We present an overview of the database with a focus on these unique computational tools and describe strategies for the use of these resources in the area of physiological genomics.
Twigger
Simon N
SN
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Pasko
Dean
D
Nie
Jeff
J
Shimoyama
Mary
M
Bromberg
Susan
S
Campbell
Dan
D
Chen
Jiali
J
dela Cruz
Norberto
N
Fan
Chunyu
C
Foote
Cindy
C
Harris
Glenn
G
Hickmann
Brian
B
Ji
Yuan
Y
Jin
Weihong
W
Li
Dawei
D
Mathis
Jedidiah
J
Nenasheva
Nataliya
N
Nigam
Rajni
R
Petri
Victoria
V
Reilly
Dorothy
D
Ruotti
Victor
V
Schauberger
Eric
E
Seiler
Kathy
K
Slyper
Ronit
R
Smith
Jennifer
J
Wang
Weiye
W
Wu
Wenhua
W
Zhao
Lan
L
Zuniga-Meyer
Angela
A
Tonellato
Peter J
PJ
Kwitek
Anne E
AE
Jacob
Howard J
HJ
D000818:Animals; D003001:Cloning, Molecular; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D016678:Genome / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D051381:Rats / Q000235:genetics* / Q000502:physiology*