title: Improvement of T1 determination of hyperpolarized 129Xe in mouse brain under controlled-flow.
abstract: The method of determining the longitudinal relaxation time of hyperpolarized 129Xe in the mouse brain has been established in vivo with the ventilation technique under controlled-flow conditions. The uptake and washout processes for nine mice were traced through observation of time-dependent changes in NMR (nuclear magnetic resonance) signal amplitudes and analyzed by means of a two-compartment model, thus providing the quantitative value of 14.1+/-1.6 s as the relaxation time.
authors.affiliation: Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. kimura@sahs.med.osaka-u.ac.jp
authors.forename: Atsuomi
authors.initials: A
authors.lastname: Kimura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Wakayama
authors.forename: Michiko
authors.initials: M
authors.lastname: Narazaki
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ueyama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019047:Phantoms, Imaging; D014979:Xenon Isotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D003287:Contrast Media; D014979:Xenon Isotopes