Severe ankylosing spondylitis and diffuse systemic sclerosis: case report of a genetic trap.
A rare association of ankylosing spondylitis (AS) and systemic sclerosis (SSc) is reported in a Brazilian Mestizo patient presenting a human leucocyte antigen (HLA) genotype that included HLA SSc-susceptibility genes previously reported in different ethnic groups and HLA-B27 associated with AS. The underlying genetic background supporting the full expression of both SSc- and AS-susceptibility alleles and the pertinent literature are discussed.
Kayser
C
C
Department of Rheumatology, Sao Paulo Federal University, UNIFESP, São Paulo, Brazil.
Alvarenga
M C V
MC
Neves
A S
AS
Gerbase-De Lima
M
M
Andrade
L E C
LE
D000328:Adult; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D012595:Scleroderma, Systemic / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000235:genetics* / Q000276:immunology
D015796:HLA-B27 Antigen