Effects of magnesium sulfate on supraceliac aortic unclamping in experimental dogs.
Intravascular administration of magnesium (Mg) causes vasodilation and increases renal blood flow. The aim of this study was to investigate the renal effect of Mg following unclamping of the supraceliac aorta. Mongrels were divided into two groups, control (group C, n=7) and Mg group (group Mg, n=7). In group Mg, 30 mg/kg MgSO4 was injected as a bolus immediately prior to unclamping the supraceliac aorta and thereafter as an infusion (10 mg/kg/hr). The group C received an equivalent volume of saline solution. Systemic hemodynamics, renal artery blood flow, renal cortical blood flow (RCBF), renal vascular resistance, and renal function were compared. Following the aortic unclamping, cardiac output and RCBF were less attenuated, and the systemic and renal vascular resistance was elevated to a lesser degree in the group Mg compared to the group C. There was no significant difference in the plasma renin activity, serum creatinine and Cystatin-C between the two groups. The present study shows that Mg infusion improves systemic hemodynamics and RCBF after aortic unclamping. However, we did not observe any improvement in renal function when Mg was administered after supraceliac aortic unclamping.
Jang
Youngho
Y
Department of Anesthesiology and Pain Medicine, School of Medicine and Institute for Medical Science, Keimyung University, Daegu, Korea. weonjo@dsmc.or.kr
Shin
Hyoung Yong
HY
Kim
Jin Mo
JM
Lee
Mi Young
MY
Keum
Dong Yoon
DY
D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology / Q000601:surgery*; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D012079:Renal Circulation / Q000187:drug effects*; D012083:Renin / Q000097:blood
D055316:Cystatin C; D015891:Cystatins; D008278:Magnesium Sulfate; D003404:Creatinine; D012083:Renin; D008274:Magnesium; D002118:Calcium