The first synthesis of chiral PNA monomer-cyclen conjugates.
A synthetic route to novel chiral PNA monomer-cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil-PNA monomer-cyclen conjugates can rapidly bind Zn2+ in aqueous solution, and the structure of the Zn(II) complex was confirmed facilely by HRMS spectra, 1H NMR spectra and elemental analysis.
Ma
Li-Jian
LJ
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu 610064, P. R. China.
Zhang
Guo-Lin
GL
Chen
Shan-Yong
SY
Wu
Bo
B
You
Jing-Song
JS
Xia
Chuan-Qin
CQ
Yu
Xiao-Qi
XQ
D002942:Circular Dichroism; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014498:Uracil / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
D000080027:Cyclams; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D020135:Peptide Nucleic Acids; D014498:Uracil; C038072:cyclen; D015032:Zinc