Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole.
The purpose of the present study was to characterize the solid state properties of ternary solid dispersions made up of PVP VA64, Myrj 52 and itraconazole. The solid dispersions were prepared by dissolving the materials in methylene chloride, followed by evaporation under reduced pressure of the solvent at 55 degrees C in a rotovapor. Binary and ternary solid dispersions were characterized by standard and modulated temperature differential scanning calorimetry and X-ray powder diffraction. Although PVP VA64 and itraconazole were found to be completely miscible in the solid state, addition of a small amount of Myrj 52 to the drug-polymer system leads to separation of itraconazole thus demonstrating that Myrj 52 expels the drug from the polymer phase.
Wang
Xin
X
Laboratorium voor Farmacotechnologie en Biofarmacie, Faculteit Farmaceutische Wetenschappen, K.U.Leuven, Campus Gasthuisberg O+N, Herestraat 49, B-3000 Leuven, Belgium.
Michoel
Armand
A
Van den Mooter
Guy
G
D000935:Antifungal Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004355:Drug Stability; D017964:Itraconazole / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature; D014753:Vinyl Compounds / Q000737:chemistry*; D014961:X-Ray Diffraction
D000935:Antifungal Agents; D004304:Dosage Forms; D011759:Pyrrolidines; D012997:Solvents; D013501:Surface-Active Agents; D014753:Vinyl Compounds; C402301:poly(vinylpyrrolidone-co-vinyl-acetate); D017964:Itraconazole; D011092:Polyethylene Glycols; D008752:Methylene Chloride; C009314:polyethylene glycol monostearate