Genomic views of chromatin.
With the availability of complete genome sequences for a number of organisms, a major challenge has become to understand how chromatin and its epigenetic modifications regulate genome function. High-throughput microarray and sequencing technologies are being combined with biochemical and immunological enrichment methods to obtain genome-scale views of chromatin in a variety of organisms. The data pinpoint novel, genomic elements and expansive chromatin domains, and offer insight into the functions of histone modifications. In parallel, state-of-the-art imaging techniques are being used to investigate higher-order chromatin organization, and are beginning to bridge our understanding of chromatin biology with that of chromosome structure.
Huebert
Dana J
DJ
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
Bernstein
Bradley E
BE
D000107:Acetylation; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D023281:Genomics; D006657:Histones / Q000378:metabolism; D008745:Methylation
D002843:Chromatin; D006657:Histones