Nuclear inositol lipid metabolism: more than just second messenger generation?
A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-beta1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
Martelli
Alberto M
AM
Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia Umana, Cell Signalling Laboratory, Università di Bologna, 40126 Bologna, Italy.
Follo
Matilde Yung
MY
Evangelisti
Camilla
C
Falà
Federica
F
Fiume
Roberta
R
Billi
Anna Maria
AM
Cocco
Lucio
L
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D050356:Lipid Metabolism; D054799:Phospholipase C beta; D015290:Second Messenger Systems; D010738:Type C Phospholipases / Q000378:metabolism
D002843:Chromatin; D007527:Isoenzymes; D007294:Inositol; D010738:Type C Phospholipases; C518033:PLCB1 protein, human; D054799:Phospholipase C beta