title: Genomic views of chromatin.
abstract: With the availability of complete genome sequences for a number of organisms, a major challenge has become to understand how chromatin and its epigenetic modifications regulate genome function. High-throughput microarray and sequencing technologies are being combined with biochemical and immunological enrichment methods to obtain genome-scale views of chromatin in a variety of organisms. The data pinpoint novel, genomic elements and expansive chromatin domains, and offer insight into the functions of histone modifications. In parallel, state-of-the-art imaging techniques are being used to investigate higher-order chromatin organization, and are beginning to bridge our understanding of chromatin biology with that of chromosome structure.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
authors.forename: Dana J
authors.initials: DJ
authors.lastname: Huebert
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Bernstein
mesh_terms: D000107:Acetylation; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D023281:Genomics; D006657:Histones / Q000378:metabolism; D008745:Methylation
chemical_list: D002843:Chromatin; D006657:Histones