Leukocytoclastic vasculitis: a rare manifestation of propylthiouracil hypersensitivity.
OBJECTIVE
We report a case of leukocytoclastic vasculitis as a manifestation of propylthiouracil hypersensitivity.


METHODS
A 66-year-old woman with a history of a toxic adenoma was referred for evaluation of a purpuric rash on the legs and buttocks bilaterally. She was biochemically hyperthyroid. Biopsy of the skin lesions revealed leukocytoclastic vasculitis. Propylthiouracil therapy was discontinued, and methimazole started. The purpuric rash resolved and surgical treatment for toxic adenoma resulted in euthyroid state.


CONCLUSIONS
This report indicated that leukocytoclastic vasculitis should be considered in the differential diagnosis of patients with a vasculitic rash. The discontinuation of the propylthiouracil was associated with disappearance of the lesions.
Erem
Cihangir
C
Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. cihangirerem@hotmail.com
Yucel
Yusuf
Y
Ya
Ziya
Z
Reis
Abdulkadir
A
Kocak
Mustafa
M
Hacihasanoglu
Arif
A
D000236:Adenoma / Q000150:complications / Q000188:drug therapy; D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005076:Exanthema / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006044:Goiter, Nodular / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy; D008713:Methimazole / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis
D013956:Antithyroid Agents; D008713:Methimazole; D011441:Propylthiouracil