Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform.
A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki-Heck-type arylation, a Liebeskind-Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.
Muraoka
Nobuhiro
N
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
Mineno
Masahiro
M
Itami
Kenichiro
K
Yoshida
Jun-ichi
J