[Antioxidative defense in patients with acute coronary syndrome and concomitant type 2 diabetes and its modification by lisinopril].
OBJECTIVE
To study antioxidative defense in patients with acute coronary syndrome (ACS) and concomitant type 2 diabetes and its modification by lisinopril.


METHODS
Activity of glutathione reductase and myeloperoxidase in neutrophils, catalase and superoxide dismutase in blood was measured in 94 patients with ACS (including 35 with diabetes) and the patients were followed up for 1 year.


RESULTS
Number of coronary events during observation was significantly higher in patients with diabetes. At baseline these patients had significantly lower catalase activity which was associated with elevated blood glucose, circulating immune complexes, creatinine, and proteinuria. Baseline catalase activity was the lowest in diabetic patients with events (reinfarction or death) during follow-up. The latter patients had highest levels of blood creatinine and proteinuria, and most pronounced left ventricular systolic dysfunction. The use of lisinopril during initial hospitalization was associated with elevation of catalase activity, lowering of creatinine and elimination of proteinuria.
Kratnov
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AE
Popov
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SA
Kratnov
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Dem'iankova
Iu O
IuO
D000208:Acute Disease; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D017706:Lisinopril / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects*; D009195:Peroxidase / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D017706:Lisinopril; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase