title: Prevalence of herpes simplex virus (types 1 and 2), varicella-zoster virus, cytomegalovirus, and human herpesvirus 6 and 7 DNA in cerebrospinal fluid of Middle Eastern patients with encephalitis.
abstract: HSV-1 DNA was detected in 32 (30%) of 106 cerebrospinal fluid samples from patients with encephalitis. Cytomegalovirus, varicella-zoster virus, and human herpesvirus 6 (HHV-6) DNAs were each detected in three patients (3%); herpes simplex virus type 2 (HSV-2) and HHV-7 PCRs were negative. HSV detection was associated with seizure (P = 0.02), especially focal seizure (P = 0.0002), and pathological computed tomography (P = 0.02) with focal lesions (P = 0.0004).
authors.affiliation: Department of Clinical Chemistry and Microbiology, University of Damascus, Syria.
authors.forename: Ali I
authors.initials: AI
authors.lastname: Ibrahim
authors.forename: Michel T
authors.initials: MT
authors.lastname: Obeid
authors.forename: Muhidien J
authors.initials: MJ
authors.lastname: Jouma
authors.forename: Klaus
authors.initials: K
authors.lastname: Roemer
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Mueller-Lantzsch
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Gärtner
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification; D004279:DNA, Viral / Q000134:cerebrospinal fluid*; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid / Q000821:virology*; D005260:Female; D006564:Herpesviridae / Q000302:isolation & purification*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000302:isolation & purification; D018258:Herpesvirus 2, Human / Q000235:genetics / Q000302:isolation & purification; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification; D016199:Herpesvirus 7, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D004279:DNA, Viral