Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving.
BACKGROUND
Dysfunction of the prefrontal cortex is implicated in craving for drugs and food. This study explores the effect of prefrontal cortex stimulation on food craving.


METHODS
In a randomized double-blind parallel group study, 28 women, who reported frequent cravings for food were exposed to foods that typically elicit strong cravings before and after a single session of real or sham 10-Hz repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex at an intensity of 110% individual motor threshold.


RESULTS
Self-reported food craving during exposure to the experimental foods remained stable before and after real stimulation compared with sham stimulation in which cravings increased over the experimental session. Consumption of snack foods within a 5-min period after stimulation did not differ between groups.


CONCLUSIONS
Prefrontal stimulation inhibits the development of craving. A longer period of observation is necessary to establish whether there is an effect on food consumption.
Uher
Rudolf
R
Institute of Psychiatry, King's College London, London, United Kingdom. r.uher@iop.kcl.ac.uk
Yoganathan
Daniella
D
Mogg
Andrew
A
Eranti
Savithasri V
SV
Treasure
Janet
J
Campbell
Iain C
IC
McLoughlin
Declan M
DM
Schmidt
Ulrike
U
D000293:Adolescent; D000328:Adult; D016739:Behavior, Addictive / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology / Q000523:psychology*; D005247:Feeding Behavior / Q000502:physiology / Q000523:psychology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D017397:Prefrontal Cortex / Q000502:physiology* / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*