Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study.
Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.
Furukawa
Toru
T
Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryomachi, Sendai, 980-8575, Japan. furukawa@mail.tains.tohoku.ac.jp
Klöppel
Günter
G
Volkan Adsay
N
N
Albores-Saavedra
Jorge
J
Fukushima
Noriyoshi
N
Horii
Akira
A
Hruban
Ralph H
RH
Kato
Yo
Y
Klimstra
David S
DS
Longnecker
Daniel S
DS
Lüttges
Jutta
J
Offerhaus
G Johan A
GJ
Shimizu
Michio
M
Sunamura
Makoto
M
Suriawinata
Arief
A
Takaori
Kyoichi
K
Yonezawa
Suguru
S
D014408:Biomarkers, Tumor / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D018282:Cystadenocarcinoma, Mucinous / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D018283:Cystadenocarcinoma, Papillary / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007124:Immunoenzyme Techniques; D009077:Mucins / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000145:classification* / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor; D009077:Mucins