title: Reactivity of a new class of P450 enzyme models.
abstract: P450 enzyme models carrying a SO3(-) ligand coordinating to iron have been synthesized and characterized. These complexes show characteristics very similar to those of iron-heme cofactors of P450 enzymes. Their reactivity towards different reactions catalyzed by P450 enzymes such as epoxidation of double bonds, hydroxylation of non-activated C-H bonds, N-dealkylation of amines, and cleavage of diols (C-C-bond cleavage) has been investigated.
authors.affiliation: Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
authors.forename: Dominik
authors.initials: D
authors.lastname: Meyer
authors.forename: Tycho
authors.initials: T
authors.lastname: Leifels
authors.forename: Laura
authors.initials: L
authors.lastname: Sbaragli
authors.forename: Wolf-D
authors.initials: WD
authors.lastname: Woggon
mesh_terms: D003198:Computer Simulation; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D013056:Spectrophotometry, Ultraviolet; D013447:Sulfites / Q000378:metabolism
chemical_list: D008024:Ligands; D013447:Sulfites; D003577:Cytochrome P-450 Enzyme System