title: Splenic hypoperfusion as a sign of systemic amyloidosis.
abstract: BACKGROUND
  The spleen is frequently involved in systemic amyloidosis; however, the computed tomographic (CT) or magnetic resonance (MR) pattern of splenic amyloidosis is not sufficiently described in the literature. This study evaluated the contrast-enhanced CT and MR findings of the spleen in patients with systemic amyloidosis.
  
  
  METHODS
  Data were extracted by reviewing pathology and radiology department records of the teaching hospital of Naples over 10 years, from 1 January 1993 to 31 December 2002. Thirty-three patients with amyloidosis were identified, 10 of whom had a CT scan and two of whom had an MR study. The population-based study was composed of 12 patients with histologically proved amyloidosis who underwent contrast-enhanced CT or MR scan of the abdomen. The spleen and liver were evaluated for organ size and perfusion.
  
  
  RESULTS
  The spleen was hypoperfused in nine of 12 patients. Mild splenomegaly was present in only one case. Hepatomegaly was associated with markedly acute left lobe margin in nine patients and with rounded anterior profile of segments 3 and 4 in four patients. Moreover, a large area of low attenuation with indefinite geographic margins involving the right hepatic lobe was observed in three patients.
  
  
  CONCLUSIONS
  The finding of splenic hypoperfusion may be a marker of systemic amyloidosis, which represents a useful clue when clinical findings fail to suggest the proper diagnosis.
authors.affiliation: IBB, University Federico II, Naples, Italy.
authors.forename: P P
authors.initials: PP
authors.lastname: Mainenti
authors.forename: L
authors.initials: L
authors.lastname: Camera
authors.forename: S
authors.initials: S
authors.lastname: Nicotra
authors.forename: T
authors.initials: T
authors.lastname: Cantalupo
authors.forename: E
authors.initials: E
authors.lastname: Soscia
authors.forename: D
authors.initials: D
authors.lastname: Di Vizio
authors.forename: G
authors.initials: G
authors.lastname: Insabato
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013154:Spleen / Q000098:blood supply*; D013158:Splenic Diseases / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed