[In vitro antifungal activity of voriconazole against dermatophytes and superficial isolates of Scopulariopsis brevicaulis].
We have studied the in vitro antifungal activity of voriconazole, fluconazole and itraconazole against 252 clinical isolates of dermatophytes and Scopulariopsis brevicaulis by a standardized agar diffusion method (NeoSensitabs). Several important factors such as temperature (28 degrees C vs. 35 degrees C) and incubation time (2-10 days vs. 18-74 h) were adapted to dermatophytes and Scopulariopsis requirements. Voriconazole showed an excellent activity against most species of dermatophytes, higher than itraconazole and fluconazole. However, S. brevicaulis isolates were highly resistant to all azoles used in this study. Voriconazole might be an interesting antifungal alternative to refractory superficial mycoses.
Carrillo-Muñoz
Alfonso Javier
AJ
Departamento de Microbiología, ACIA, Apartado Postal 10178, E-08080, Barcelona, Spain. acarrillo@ya.com
Cárdenes
Carmen Delia
CD
Carrillo-Orive
Bartolomé
B
Rodríguez
Virginia
V
Del Valle
Osacr
O
Casals
José Bou
JB
Ezkurra
Pilar Ariadna
PA
Quindós
Guillermo
G
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000302:isolation & purification; D001203:Ascomycota / Q000187:drug effects* / Q000302:isolation & purification; D003881:Dermatomycoses / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D026141:Drug Resistance, Multiple, Fungal; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; D065819:Voriconazole