The genetics of human drug response.
The genetics of variable drug response appears to be a more tractable complex trait than common disease predisposition. This has implications for prioritizing research and for experimental design, and in particular argues for extensive use of candidate gene based approaches in pharmacogenetic association studies. Eventually, when whole genome scanning becomes feasible, it may be appropriate to consider weighting schemes that assign higher prior probabilities of variants in genes related to the mode of action of metabolism of medicines.
Goldstein
David B
DB
Department of Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK. d.goldstein@duke.edu
D005796:Genes / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends*; D010599:Pharmacokinetics