title: Acne is not a stigma of HIV infection: a review of 36 patients.
abstract: BACKGROUND
  Several diseases with follicular occlusion have been described in HIV-infected patients and can appear isolated or associated with each other in an independent disease named 'HIV-associated follicular syndrome'. Worsening of cutaneous lesions during the course of infection in patients with previous acne vulgaris, late onset or severe forms of acne have been reported in HIV-infected patients.
  
  
  METHODS
  A prospective study of 335 HIV-infected patients was performed in our hospital. A meticulous dermatological exploration in all patients was made, and multiple data were stored into a Microsoft Access 97 program. Patients diagnosed as having acne were considered separately, and we studied their characteristics. A statistical analysis with SPSS 9.0 (Statistical Package for the Social Sciences) was performed.
  
  
  RESULTS
  Thirty-six patients (10.8%) were diagnosed as having acne. Papulopustular lesions were the most frequent clinical presentation. Most lesions were localized on the face or on the back, and 80% of patients had mild to moderate acne; 40% of them required no treatment and the remainder was treated with topical measures, oral antibiotics and isotretinoin. 85% of cases reported the onset of acne during adolescence or before HIV infection and without any relationship with this disease. No relation between acne intensity and stage of HIV infection was observed. A multivariate analysis showed that the most important variable was age.
  
  
  CONCLUSIONS
  In contrast to previous reports, no greater intensity or modifications in acne lesions were observed in our HIV-infected patients during the course of the disease. In the majority of cases, cutaneous lesions started before HIV infection, during adolescence, and the most important factor for suffering from acne was young age. In contrast to data reported in the literature, no relation of acne lesions to CD4 lymphocyte count or AIDS case criteria was found in our patients.
  
  
  CONCLUSIONS
  Acne in HIV-infected patients has characteristics similar to those in non-HIV-infected patients. The age is the most important factor for the appearance of lesions that usually develop during adolescence. Acne lesions are not modified by HIV infection, and no relationship with the severity of HIV infection has been observed.
authors.affiliation: Department of Dermatology, Juan Canalejo Hospital, La Coruña, Spain. almagro@canalejo.org
authors.forename: M
authors.initials: M
authors.lastname: Almagro
authors.forename: J
authors.initials: J
authors.lastname: Del Pozo
authors.forename: J
authors.initials: J
authors.lastname: García-Silva
authors.forename: M
authors.initials: M
authors.lastname: Pérez-García
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez-Lozano
authors.forename: S
authors.initials: S
authors.lastname: Pértega
authors.forename: E
authors.initials: E
authors.lastname: Fonseca
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011336:Probability; D011446:Prospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution
chemical_list: D019380:Anti-HIV Agents; D007641:Keratolytic Agents