title: Wegener's granulomatosis with eosinophilia.
abstract: Wegener's granulomatosis with eosinophilia both in blood and tissue samples has been rarely reported. A 25-year-old woman developed fever, granulomatous inflammation of nasal mucosa, pulmonary hemorrhage, suprascleritis, and cutaneous vasculitis. She showed eosinophilia in blood and biospy samples of skin, nasal mucosa, and lung. She was positive for proteinase 3-antineutrophil cytoplasmic antibody. She had no history of asthma. We diagnosed her as Wegener's granulomatosis with eosinophilia rather than Churg-Strauss syndrome. Her mucocutaneous and pulmonary lesions were successfully treated with high-dose corticosteroid and methotrexate, but her suprascleritis required pulsed cyclophosphamide.
authors.affiliation: Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shoda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kanda
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tanaka
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Komagata
authors.forename: Yoshikata
authors.initials: Y
authors.lastname: Misaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D001168:Arthritis / Q000209:etiology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004802:Eosinophilia / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D009297:Nasal Mucosa / Q000473:pathology; D015423:Scleritis / Q000188:drug therapy / Q000209:etiology
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008727:Methotrexate