title: Prevention of perinatal transmission of hepatitis B to babies at high risk: an evaluation.
abstract: We aimed to determine factors associated with successful vaccination coverage and development of infection in high-risk infants born to hepatitis B infected women. Immunisation of 860/932 (92%) of babies was started within 48 h of birth and three doses of vaccination completed for 794/921 (86%). Only 543 (58%) infants were tested and 26 (4.9%) were found to have evidence of current infection. Delayed start of immunisation was significantly associated with unbooked pregnancy, maternal hepatitis B e-markers and year. Current infection in the baby was strongly associated with maternal hepatitis B e-status, ethnicity and year of vaccination. The proportion of infants developing infection declined after 1998, coinciding with the publication of national recommendations and the wider use of the accelerated schedule.
authors.affiliation: Immunisation Department, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK.
authors.forename: David
authors.initials: D
authors.lastname: Sloan
authors.forename: Mary
authors.initials: M
authors.lastname: Ramsay
authors.forename: Leonie
authors.initials: L
authors.lastname: Prasad
authors.forename: David
authors.initials: D
authors.lastname: Gelb
authors.forename: Chong Gee
authors.initials: CG
authors.lastname: Teo
mesh_terms: D018562:Disease Transmission, Infectious; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000517:prevention & control* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control / Q000821:virology; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines