Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians.
Negative affect such as depression and anxiety has been reported to be associated with morbidity and mortality, and polymorphisms of the serotonin transporter (5HTT) gene may be associated with such affect disorders. Hypothesizing that 5HTT gene polymorphisms could influence human longevity via negative affect; we compared the polymorphic variation of the 5HTT gene between 265 Japanese centenarians and control subjects. In addition, we evaluated the relationships between the 5HTT genotype and the physical, cognitive, and biologic status of centenarians, as indicated by the Barthel Index, the Mini-Mental State Examination, and serum albumin concentration, respectively. The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly women. A significant effect of the 5HTT genotype on serum albumin concentration was observed in both sexes. Although, there was sex optionality, the l allele may carry a longevity advantage possibly through behavioral mechanisms.
Gondo
Yasuyuki
Y
Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan. ygondo@tmig.or.jp
Hirose
Nobuyoshi
N
Arai
Yasumichi
Y
Yamamura
Ken
K
Shimizu
Ken-Ichirou
K
Takayama
Michiyo
M
Ebihara
Yoshinori
Y
Nakazawa
Susumu
S
Inagaki
Hiroki
H
Masui
Yukie
Y
Kitagawa
Koji
K
D000328:Adult; D000339:Affect / Q000502:physiology*; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005838:Genotype; D015577:Geriatric Assessment; D006801:Humans; D007564:Japan; D008136:Longevity / Q000235:genetics* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism
D050486:Serotonin Plasma Membrane Transport Proteins