title: Wavelength and vulnerability to atrial fibrillation: Insights from a computer model of human atria.
abstract: OBJECTIVE
  To explain the contradictory results related to the concept of critical cardiac wavelength in the initiation and perpetuation of atrial fibrillation (AF).
  
  
  METHODS
  A biophysically based computer model was used to: (1) study the relationship between wavelength and AF perpetuation in the presence of multiple re-entrant wavelets, (2) evaluate the performance of different existing methods for wavelength estimation in the presence of different arrhythmogenic substrates, and (3) document the impact of either heterogeneities in refractoriness or the presence of a mother rotor on wavelength estimation.
  
  
  RESULTS
  The simulations confirmed that the wavelength must be below a critical value for AF to be sustained, when the perpetuation mechanism relies on multiple re-entrant wavelets. The estimated value of wavelength was not the same for all methods tested and depended in part on the nature of the spatio-temporal organization of the AF dynamics.
  
  
  CONCLUSIONS
  A priori information about the underlying wavelet dynamics is needed for a correct interpretation of the cardiac wavelength as estimated by the current clinical methods.
authors.affiliation: Signal Processing Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 11, Switzerland. vincent.jacquemet@epfl.ch
authors.forename: Vincent
authors.initials: V
authors.lastname: Jacquemet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Virag
authors.forename: Lukas
authors.initials: L
authors.lastname: Kappenberger
mesh_terms: D001281:Atrial Fibrillation / Q000503:physiopathology*; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans