title: Contact-dependent inhibition of growth in Escherichia coli.
abstract: Bacteria have developed mechanisms to communicate and compete with each other for limited environmental resources. We found that certain Escherichia coli, including uropathogenic strains, contained a bacterial growth-inhibition system that uses direct cell-to-cell contact. Inhibition was conditional, dependent upon the growth state of the inhibitory cell and the pili expression state of the target cell. Both a large cell-surface protein designated Contact-dependent inhibitor A (CdiA) and two-partner secretion family member CdiB were required for growth inhibition. The CdiAB system may function to regulate the growth of specific cells within a differentiated bacterial population.
authors.affiliation: Molecular, Cellular, and Developmental Biology, University of California-Santa Barbara (UCSB), Santa Barbara, CA 93106, USA.
authors.forename: Stephanie K
authors.initials: SK
authors.lastname: Aoki
authors.forename: Rupinderjit
authors.initials: R
authors.lastname: Pamma
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Hernday
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Bickham
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Braaten
authors.forename: David A
authors.initials: DA
authors.lastname: Low
mesh_terms: D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D019295:Computational Biology; D003260:Contact Inhibition; D017077:Culture Media, Conditioned; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity / Q000502:physiology; D048168:Escherichia coli K12 / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D010861:Fimbriae, Bacterial / Q000378:metabolism; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D044404:Genomic Islands; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D009154:Mutation; D016366:Open Reading Frames; D014774:Virulence
chemical_list: C503242:CdiA protein, E coli; C513104:CdiB protein, E coli; D017077:Culture Media, Conditioned; D029968:Escherichia coli Proteins; D008565:Membrane Proteins