title: [Effects of early weaning on the blood glucose, blood lipid and hormone of rat fed a high fat diet].
abstract: OBJECTIVE
  To observe the effects of early weaning on the blood glucose, blood lipid and hormone of rat fed a high fat diet.
  
  
  METHODS
  Male Wistar rats were randomly divided into two groups after born 17 days according to body weight. One group was early weaned in the 17th day, the other was breastfed until the 24th day. After 4 weeks fed with basic diet, 12 rats were randomly selected from each group and were sacrificed. The other rats of each group were further randomly divided into 2 groups according to body weight. One group was fed a high fat diet, the other was fed the basic diet. The rats were sacrificed respectively at the end of the experiment. The blood glucose, serum lipids, and hormones were measured.
  
  
  RESULTS
  Compared with the normal weaning rats, the weight and fat pad of early weaning rats significantly increased and the level of blood glucose, serum lipids, insulin, leptin also increased significantly (P < 0.05), the level of HDL, FT3 decreased (P < 0.05).
  
  
  CONCLUSIONS
  The tendency of obesity in early weaning rats were more obvious than normal weaning rats after fed a high fat diet.
authors.affiliation: School of Public Health, Harbin Medical University, Harbin 150086, China.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Wang
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Sun
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005247:Feeding Behavior / Q000502:physiology; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014886:Weaning
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D008055:Lipids