title: Neutrophil-derived serine proteases in immune complex-mediated diseases.
abstract: Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.
authors.affiliation: Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Sofia Z
authors.initials: SZ
authors.lastname: Raptis
authors.forename: Christine T N
authors.initials: CT
authors.lastname: Pham
mesh_terms: D000818:Animals; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D003594:Cytoplasmic Granules / Q000201:enzymology; D006801:Humans; D007105:Immune Complex Diseases / Q000201:enzymology* / Q000276:immunology*; D007239:Infections / Q000201:enzymology / Q000276:immunology; D007249:Inflammation / Q000201:enzymology / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology*; D012697:Serine Endopeptidases / Q000276:immunology*
chemical_list: D012697:Serine Endopeptidases