[Maternal diabetes and congenital malformations].
Maternal diabetes is a known risk factor for congenital malformations. Maternal hyperglycemia is a non-specific teratogen. The risk of congenital malformations, even with optimal metabolic control, is considerably elevated compared with non-diabetic pregnancies. The relationship between maternal hyperglycemia in early pregnancy and the risk of congenital malformations seems to be linear without any threshold level. To diminish the risk of congenital malformations, close preconceptional and first-trimester diabetic control and folic acid supplementation of 5 mg/day are recommended.
Johansen
Malene Nygaard
MN
Syddansk Universitet, Epidemiologi, og Kolding Sygehus, Børneafdelingen. malene.johansen@get2net.dk
Garne
Ester
E
D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D012307:Risk Factors
D005492:Folic Acid