[Biological properties of HIV-1 variants circulating among drug users in Russia].
Human immunodeficiency virus type 1 variants belonging to subtype A, as well as recombinant gaga/engvB variants, derived from HIV-infected patients living in the Moscow and Perm Regions, were isolated and characterized. Intravenous administration of psychoactive drugs was a major risk factor of the infection for all the patients. All the examined isolates of HIV-1 types A and A/B were shown to be characterized by a low virus-specific activity and to be used as secondary CCR5 and CXCR4 protein receptors. The findings suggest that the domination of subtype A variant in this risk group is unassociated with fundamental differences in biological properties between the isolates of this subtype and recombinant viruses.
Khanina
T A
TA
Selimova
L M
LM
Kazennikova
E V
EV
Bobkov
A F
AF
Bobkova
M R
MR
Pokrovskiĭ
V V
VV
Zverev
S Ia
SIa
Braganza
R
R
Nicolson
K
K
Weber
D
D
D000595:Amino Acid Sequence; D005260:Female; D015752:Genes, env / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D012426:Russia / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000821:virology*