title: Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis.
abstract: Genome features of the Bacillus cereus group genomes (representative strains of Bacillus cereus, Bacillus anthracis and Bacillus thuringiensis sub spp. israelensis) were analyzed and compared with the Bacillus subtilis genome. A core set of 1381 protein families among the four Bacillus genomes, with an additional set of 933 families common to the B. cereus group, was identified. Differences in signal transduction pathways, membrane transporters, cell surface structures, cell wall, and S-layer proteins suggesting differences in their phenotype were identified. The B. cereus group has signal transduction systems including a tyrosine kinase related to two-component system histidine kinases from B. subtilis. A model for regulation of the stress responsive sigma factor sigmaB in the B. cereus group different from the well studied regulation in B. subtilis has been proposed. Despite a high degree of chromosomal synteny among these genomes, significant differences in cell wall and spore coat proteins that contribute to the survival and adaptation in specific hosts has been identified.
authors.affiliation: Integrated Genomics, 2201 W. Campbell Park Dr., Chicago, IL 60612, USA.
authors.forename: Iain
authors.initials: I
authors.lastname: Anderson
authors.forename: Alexei
authors.initials: A
authors.lastname: Sorokin
authors.forename: Vinayak
authors.initials: V
authors.lastname: Kapatral
authors.forename: Gary
authors.initials: G
authors.lastname: Reznik
authors.forename: Anamitra
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Natalia
authors.initials: N
authors.lastname: Mikhailova
authors.forename: Henry
authors.initials: H
authors.lastname: Burd
authors.forename: Victor
authors.initials: V
authors.lastname: Joukov
authors.forename: Denis
authors.initials: D
authors.lastname: Kaznadzey
authors.forename: Theresa
authors.initials: T
authors.lastname: Walunas
authors.lastname: Markd'Souza
authors.forename: Niels
authors.initials: N
authors.lastname: Larsen
authors.forename: Gordon
authors.initials: G
authors.lastname: Pusch
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Liolios
authors.forename: Yuri
authors.initials: Y
authors.lastname: Grechkin
authors.forename: Alla
authors.initials: A
authors.lastname: Lapidus
authors.forename: Eugene
authors.initials: E
authors.lastname: Goltsman
authors.forename: Lien
authors.initials: L
authors.lastname: Chu
authors.forename: Michael
authors.initials: M
authors.lastname: Fonstein
authors.forename: S Dusko
authors.initials: SD
authors.lastname: Ehrlich
authors.forename: Ross
authors.initials: R
authors.lastname: Overbeek
authors.forename: Nikos
authors.initials: N
authors.lastname: Kyrpides
authors.forename: Natalia
authors.initials: N
authors.lastname: Ivanova
mesh_terms: D001408:Bacillus anthracis / Q000235:genetics*; D001409:Bacillus cereus / Q000235:genetics*; D001412:Bacillus subtilis / Q000235:genetics*; D001413:Bacillus thuringiensis / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics; D002473:Cell Wall / Q000235:genetics; D016680:Genome, Bacterial; D023281:Genomics; D008562:Membrane Glycoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D026801:Synteny
chemical_list: D001426:Bacterial Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C055764:S-layer proteins