Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones.
A novel one-step synthesis of 2,3-dihydro-1H-quinazolin-4-ones from 2-nitrobenzamides is reported. These reactions are mediated by stannous chloride in 0.02 M methanolic or ethanolic HCl solution and proceed in good yields.
Yoo
Choong Leol
CL
Department of Chemistry, University of California-Davis, One Shields Avenue, Davis, CA 95616-5295, USA. mjkurth@ucdavis.edu
Fettinger
James C
JC
Kurth
Mark J
MJ
D000438:Alcohols / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011799:Quinazolines / Q000138:chemical synthesis*; D017971:Tin Compounds / Q000737:chemistry*
D000438:Alcohols; D001549:Benzamides; D011799:Quinazolines; D017971:Tin Compounds; C023599:stannous chloride