title: Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence.
abstract: Genetic factors play a role in the vulnerability to cocaine dependence. The reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. The present study examines the role of the variants TaqI A of the dopamine D2 receptor gene and BalI of the dopamine D3 receptor gene in a Brazilian sample consisting of 730 cocaine dependents and 782 healthy controls. The studied polymorphisms did not show any difference in allelic frequencies or genotypic distribution between the groups. Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.
authors.affiliation: Neuroscience Laboratory, Department of Psychiatry, University of São Paulo School of Medicine, Brazil.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Messas
authors.forename: Ivanor
authors.initials: I
authors.lastname: Meira-Lima
authors.forename: Marília
authors.initials: M
authors.lastname: Turchi
authors.forename: Olavo
authors.initials: O
authors.lastname: Franco
authors.forename: Camila
authors.initials: C
authors.lastname: Guindalini
authors.forename: Adauto
authors.initials: A
authors.lastname: Castelo
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Laranjeira
authors.forename: Homero
authors.initials: H
authors.lastname: Vallada
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D019970:Cocaine-Related Disorders / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3
chemical_list: D017931:DNA Primers; C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3