[Establishment of maca mulatta model of resuscitation after selective cerebral ultra-deep hypothermic blood flow occlusion].
OBJECTIVE
To study the feasibility of resuscitation after selective cerebral ultra-deep hypothermia and blood flow occlusion.


METHODS
Ten 4-10 year-old maca mulattas were divided into 3 groups: four-vessel occlusion group, two-vessel occlusion group and identical temperature perfusion group. MRI were examinated before and after operation, the vital signs and the hemodynamical parameters were observed during the experiment, neurological deficient evaluation was performed after operation.


RESULTS
In all of the ten monkeys, the hemodynamical parameters of two-vessel occulation were steady during the operation, and all of them lived after filling 60 minutes. MRI were normal after operation, and the function of neurological deficient scale was normal. The others of identical temperature perfusion group and four-vessel occlusion group were not resuscitation after filling 60 minutes and died.


CONCLUSIONS
Monkey could resuscitate from selective cerebral ultra-deep hypothermia and blood flow occlusion of bilateral common carotid artery in 60 minutes.
Zhou
Jie
J
Department of Neurosurgery, the Second Affiliated Hospital of Kunming Medical College, Kunming 650101, China.
Feng
Zhong-tang
ZT
Gao
Yong-jun
YJ
Fang
Shao-long
SL
Fu
Deng-li
DL
Jiang
Ji-yao
JY
Xu
Wei
W
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control*; D017536:Carotid Artery, Common / Q000601:surgery; D004195:Disease Models, Animal; D005112:Extracorporeal Circulation / Q000009:adverse effects* / Q000379:methods; D007036:Hypothermia, Induced; D008253:Macaca mulatta; D008297:Male; D015424:Reperfusion / Q000379:methods*; D012151:Resuscitation; D014711:Vertebral Artery / Q000601:surgery