title: Maternal and female fetal virilization caused by pregnancy luteomas.
abstract: OBJECTIVE
  To present the maternal and female fetal virilization caused by excessive androgen secretion of pregnancy luteomas.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University-based teaching hospital.
  
  
  METHODS
  A nulligravida woman suffering from bilateral hydronephrosis and recurrent acute pyelonephritis caused by bilateral solid ovarian tumors presented virilization during the third trimester. Without prompt surgical intervention, the maternal hyperandrogenemia returned to a normal level and regression of bilateral ovarian tumors occurred spontaneously after a female fetus with clitoral hypertrophy and temporal hyperandrogenemia was delivered. In spite of lacking histology, the clinical course is compared to that of pregnancy luteomas.
  
  
  METHODS
  Noninvasive imaging assessment.
  
  
  METHODS
  Maternal and female fetal virilization.
  
  
  RESULTS
  Regression of androgen-secreting pregnancy luteomas and hyperandrogenism during the puerperium but apparent female fetal clitoral hypertrophy.
  
  
  CONCLUSIONS
  The maternal and female fetal virilization was caused by exaggerating androgen secretion of bilateral ovarian solid tumors. Spontaneous regression of ovarian tumors and hyperandrogenemia during the puerperium is the natural course of pregnancy luteomas, not true neoplasms.
authors.affiliation: Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei, Taiwan, ROC.
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Wang
authors.forename: Her-Young
authors.initials: HY
authors.lastname: Su
authors.forename: Jah-Yao
authors.initials: JY
authors.lastname: Liu
authors.forename: Fung-Wei
authors.initials: FW
authors.lastname: Chang
authors.forename: Chi-Huang
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D018311:Luteoma / Q000150:complications / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014770:Virilism / Q000175:diagnosis* / Q000209:etiology