Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry.
In this paper, an analytical method for the determination of six iodinated X-ray contrast agents (amidotrizoic acid, iohexol, iomeprol, iopamidol, iopromide, and ioxitalamic acid), iodide, and iodate in water samples is presented. The method is based on a separation of the analytes by ion chromatography (IC) and a subsequent detection by inductively-coupled plasma mass spectrometry (ICP-MS). The method was optimised with respect to separation conditions (column type and eluent composition) and extensively validated. Without pre-concentration of the samples, limits of detection below 0.2 microg/l could be achieved whereby reproducibility was below 6% for all compounds under investigation.
Sacher
Frank
F
DVGW-Technologiezentrum Wasser, Karlsruher Strasse 84, 76139 Karlsruhe, Germany. sacher@tzw.de
Raue
Brigitte
B
Brauch
Heinz-Jürgen
HJ
D002852:Chromatography, Ion Exchange / Q000295:instrumentation / Q000379:methods*; D003287:Contrast Media / Q000032:analysis*; D003974:Diatrizoate Meglumine / Q000032:analysis; D017613:Iodine Compounds / Q000032:analysis; D007457:Iodine Radioisotopes; D007472:Iohexol / Q000031:analogs & derivatives / Q000032:analysis; D007479:Iopamidol / Q000031:analogs & derivatives / Q000032:analysis; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000032:analysis; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D014874:Water Pollutants, Chemical / Q000032:analysis*
D003287:Contrast Media; D017613:Iodine Compounds; D007457:Iodine Radioisotopes; D014874:Water Pollutants, Chemical; D007483:Iothalamic Acid; C057937:iomeprol; D003974:Diatrizoate Meglumine; D007472:Iohexol; C038192:iopromide; C002587:ioxitalamic acid; D007479:Iopamidol