IGF-1, inflammation and stem cells: interactions during muscle regeneration.
Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental processes, such as proliferation, differentiation, survival, growth, apoptosis and regeneration. Mouse genetics have provided important insights into the signalling mechanisms that are necessary for the coordination of muscle repair. Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms.
Mourkioti
Foteini
F
EMBL Mouse Biology Unit Campus A. Buzzati-Traverso, via Ramarini 32, 00016 Monterotondo-Scalo (RM), Italy.
Rosenthal
Nadia
N
D000818:Animals; D007249:Inflammation / Q000276:immunology; D007334:Insulin-Like Growth Factor I / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D018482:Muscle, Skeletal / Q000276:immunology / Q000502:physiology*; D012038:Regeneration / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013234:Stem Cells / Q000276:immunology
D007334:Insulin-Like Growth Factor I