title: Echoes from the past--are we still in an RNP world?
abstract: Availability of the human genome sequence and those of other species is unmeasured in their value for a comprehensive understanding of the architecture, function and evolution of genomes and cells. Various mechanisms keep genomes in flux and generate intra- and interspecies variation. The conversion of RNA modules into DNA and their more or less random integration into chromosomes (retroposition) is in many lineages including our own the most pervasive and perhaps the most enigmatic. The proclivity of such events in extant multicellular eukaryotes, even in more recent evolutionary times, gives the impression that the transition period from the RNP (ribonucleoprotein) world to the emergence of modern cells, where DNA became the predominant carrier of genetic information, has lasted billions of years and is an endlessly drawn-out process rather than the punctuated event one might expect. Apart from the impact of such RNA-mediated processes as retroposition, the role of RNA in a wide variety of cellular functions has only recently become more widely appreciated.
authors.affiliation: Institute of Experimental Pathology, ZMBE, University of Munster, Munster, Germany. RNA.world@uni-muenster.de
authors.forename: J
authors.initials: J
authors.lastname: Brosius
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans; D018626:Retroelements / Q000235:genetics*
chemical_list: D018626:Retroelements