A risk score predicted coronary heart disease and stroke in a Chinese cohort.
OBJECTIVE
This article aims to address two issues: first, whether risk scores derived from Caucasian cohorts can accurately predict coronary heart disease (CHD) in a Chinese population; second, derivation and validation of a new risk prediction score for cardiovascular disease (CVD) from a Chinese cohort.


METHODS
A cohort of 4,400 male steelworkers (18-74 years old) recruited between 1974-1980 was followed up for an average 13.5 years. A Cox model was used to predict 10 year risk of CHD, ischemic, and hemorrhagic stroke based on blood pressure, age, total cholesterol, body mass index, and smoking status.


RESULTS
The prediction rule from the European Recommendations greatly overestimates the risk of CHD in Orientals. The new models had good predictive ability, with the area under receiver operating characteristic curves (AUCs area) in the derivation set being 0.76, 0.72, and 0.82 for CHD, ischemic, and hemorrhagic stroke separately; AUCs in the validation set were equally good, at 0.76, 0.78, and 0.82, respectively.


CONCLUSIONS
The risk stratification rules derived from Caucasian cohorts overestimates the CHD risk in Orientals, and we derive a specific risk stratification rule for CHD, ischemic and hemorrhagic stroke for Chinese men.
Zhang
Xiao-Fei
XF
Department of Epidemiology, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College, People's Republic of China. zhang_xiaofei@hotmail.com
Attia
John
J
D'Este
Catherine
C
Yu
Xue-Hai
XH
Wu
Xi-Gui
XG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology / Q000208:ethnology; D003327:Coronary Disease / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D004812:Epidemiologic Methods; D006801:Humans; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D018570:Risk Assessment / Q000379:methods*; D020521:Stroke / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology*; D044465:White People