title: Outcome in patients with basilar artery occlusion treated conventionally.
abstract: BACKGROUND
  Most data on the outcome of basilar artery occlusion are from recent case series of patients treated with intra-arterial thrombolysis. The limited knowledge on the outcome after a conventional treatment approach comes from a few small case series of highly selected patients.
  
  
  OBJECTIVE
  To provide more data on the outcome of conventional treatment.
  
  
  METHODS
  Data were analysed on patients from three centres with symptomatic basilar artery occlusion treated conventionally. Conventional therapy was defined as treatment with antiplatelets, anticoagulation, or both.
  
  
  RESULTS
  Data were available on 82 patients. The case fatality was 40%. Among survivors, 65% remained dependent (Rankin score 4-5). Patients younger than 60 years (odds ratio = 3.1 (95% confidence interval, 1.0 to 9.5)) and those with a minor stroke (OR = 3.1 (1.0 to 9.6)) were more likely to have a good outcome (Rankin score 0-3). Patients with a progressive stroke were less likely to have a good outcome (OR = 0.3 (0.08 to 1.2)) than patients with a maximum deficit at onset or fluctuating symptoms at presentation.
  
  
  CONCLUSIONS
  Conventional treatment of symptomatic basilar artery occlusion is associated with a poor outcome in almost 80% of patients, which emphasises the importance of the search for a more effective treatment approach.
authors.affiliation: University Medical Centre Utrecht, Department of Neurology, HP G 03.228, PO Box 85500, 3508 GA Utrecht, Netherlands. w.j.schonewille@neuro.azu.nl
authors.forename: W J
authors.initials: WJ
authors.lastname: Schonewille
authors.forename: A
authors.initials: A
authors.lastname: Algra
authors.forename: J
authors.initials: J
authors.lastname: Serena
authors.forename: C A
authors.initials: CA
authors.lastname: Molina
authors.forename: L J
authors.initials: LJ
authors.lastname: Kappelle
mesh_terms: D000367:Age Factors; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014715:Vertebrobasilar Insufficiency / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors