title: Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma.
abstract: OBJECTIVE
  To report a case of the lacrimal gland tumor diagnosed as carcinosarcoma (true mixed tumor) arising from a pleomorphic adenoma.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  An 80-year-old Japanese woman was referred with a well-circumscribed tumor in the lacrimal fossa.
  
  
  RESULTS
  The tumor was excised, but the deepest portion remained because of heavy bleeding. Histopathologically, the tumor consisted of osteosarcomatous cells. No epithelial or myoepithelial component was identified by immunohistochemistry. Two months later, the tumor progressed further and was excised completely with lateral orbitotomy. The tumor consisted primarily of osteosarcomatous component but also had epithelial components including carcinoma and pleomorphic adenoma. Examinations did not detect local recurrence and metastasis at 10 post-operative months.
  
  
  CONCLUSIONS
  The tumor was diagnosed as true carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. When lacrimal gland tumors containing sarcomatous components are encountered, carcinosarcoma should be included in the differential diagnosis.
authors.affiliation: Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan. takahira@kenroku.kanazawa-u.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahira
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Minato
authors.forename: Nobutada
authors.initials: N
authors.lastname: Katori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
mesh_terms: D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005134:Eye Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor