[Effectiveness of antireflux therapy in asthmatic children with gastroesophageal reflux disease].
There is an increased interest within literature regarding the relationship between gastro-esophageal reflux disease and asthma. The study was performed to assess the efficiency of antireflux therapy in asthmatic children. In a group of asthmatic children (n = 34, 22 male, age range: 2, 5-17 years) the pulmonary function tests were made by means of spirometry in those patients in which reflux disease was diagnosed by means of 24h esophageal pH-monitoring and upper digestive endoscopy. All these patients were reevaluated by means of spirometry 3 months after the antireflux therapy with ranitidine and cisapride added to antiasthmatic therapy. Three months later the results showed a significant decrease in frequency of asthma exacerbations from 3.18 +/- 4.86 to 0.45 +/- 0.80 (p = 0.016). There is also a significant increase of FEV1 (p = 0.04) and of FEV1/FVC (p = 0.018) in asthmatic patients with reflux disease and a positive symptomatic index, and of FEV1/FVC (p = 0.002) in all asthmatic children with abnormal gastro-esophageal reflux respectively. In conclusion, by adding antireflux therapy in asthmatic children there is a significant improvement in clinical and some of functional parameters.
Farcău
Dorin
D
Clinica Pediatric III - UMF "Iuliu Haţieganu", Cluj-Napoca, România.
Dreghiciu
Daniela
D
Cherecheş-Panţa
Paraschiva
P
Popa
Mirela
M
Farcău
Mihaela
M
Nanulescu
Mircea
M
D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D020117:Cisapride / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D011899:Ranitidine / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D018927:Anti-Asthmatic Agents; D000897:Anti-Ulcer Agents; D001993:Bronchodilator Agents; D011899:Ranitidine; D020117:Cisapride