Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence.
Genetic factors play a role in the vulnerability to cocaine dependence. The reinforcing properties of cocaine are related to the dopaminergic system, and, in particular, the dopamine receptors have been linked to the reward mechanisms. The present study examines the role of the variants TaqI A of the dopamine D2 receptor gene and BalI of the dopamine D3 receptor gene in a Brazilian sample consisting of 730 cocaine dependents and 782 healthy controls. The studied polymorphisms did not show any difference in allelic frequencies or genotypic distribution between the groups. Our data do not support a role for the dopamine D2 receptor gene TaqI A and dopamine D3 receptor gene BalI gene polymorphisms in the susceptibility to cocaine dependence in a Brazilian sample.
Messas
Guilherme
G
Neuroscience Laboratory, Department of Psychiatry, University of São Paulo School of Medicine, Brazil.
Meira-Lima
Ivanor
I
Turchi
Marília
M
Franco
Olavo
O
Guindalini
Camila
C
Castelo
Adauto
A
Laranjeira
Ronaldo
R
Vallada
Homero
H
D001483:Base Sequence; D016022:Case-Control Studies; D019970:Cocaine-Related Disorders / Q000235:genetics*; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3
D017931:DNA Primers; C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3