Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.
Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand (i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.
Williams
Fionnuala
F
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland. fionnuala.williams@bll.n-i.nhs.uk
Meenagh
Ashley
A
Sleator
Carole
C
Cook
Daniel
D
Fernandez-Vina
Marcelo
M
Bowcock
Anne M
AM
Middleton
Derek
D
D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D018448:Models, Immunological; D010641:Phenotype; D011971:Receptors, Immunologic / Q000235:genetics*; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3
D015236:HLA-C Antigens; C093100:KIR2DL1 protein, human; C496212:KIR2DS1 protein, human; C433932:KIR2DS2 protein, human; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3