The role of adrenomedullin in angiogenesis.
Adrenomedullin (AM) is a 52 amino acid peptide originally isolated from human pheochromocytoma. It was initially demonstrated to have profound effects in vascular cell biology, since AM protects endothelial cells from apoptosis, promotes angiogenesis and affects vascular tone and permeability. This review article summarizes the literature data concerning the relationship between AM and angiogenesis and describes the relationship between vascular endothelial growth factor, hypoxia and AM and tumor angiogenesis. Finally, the role of AM as a potential target of antiangiogenic therapy is discussed.
Ribatti
Domenico
D
Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico, I-70124 Bari, Italy. ribatti@anatomia.uniba.it
Nico
Beatrice
B
Spinazzi
Raffaella
R
Vacca
Angelo
A
Nussdorfer
Gastone G
GG
D053607:Adrenomedullin; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D015870:Gene Expression; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010455:Peptides / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D010455:Peptides; D042461:Vascular Endothelial Growth Factor A; D053607:Adrenomedullin