Philadelphia-chromosome positive thrombocythemia in a child.
Philadelphia-chromosome positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood has been described in adults. It is rare in children. We present a case of Philadelphia positive thrombocythemia in a child who was managed with a combination of imatinib and hydroxyurea. Although a reduction in the BCR-ABL transcript was documented, the thrombocytosis was refractory to imatinib alone and required the addition of hydroxyurea.
Mishra
Pravas
P
Department of Hematology, AIIMS, Delhi, India.
Mahapatra
M
M
Kumar
Rajat
R
Dixit
Ashish
A
Chatterjee
Tathagat
T
Tyagi
Seema
S
Choudhry
D R
DR
Sazawal
S
S
Choudhry
V P
VP
D001549:Benzamides; D001853:Bone Marrow / Q000648:ultrastructure; D002648:Child; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000627:therapeutic use; D000068877:Imatinib Mesylate; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use; D013922:Thrombocytosis / Q000188:drug therapy / Q000235:genetics*
D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D006918:Hydroxyurea