New gene and cell-based therapies for lung cancer.
Lung cancer is the leading cause of cancer-related mortality in men and women in the United States, in part, because of the poor treatment options available. New treatment strategies that specifically target discreet steps in the molecular and cellular pathogenesis of this disease are under development. This review highlights many of the basic defects that result in the cellular transformation and subsequent progression of lung cancer, and how the understanding of those fundamental defects lead to the formulation of rational gene-based or cell-based therapies.
Batra
R K
RK
Division of Pulmonary and Critical Care Medicine, GLA-VAHCS, UCLA School of Medicine, Jonsson Comprehensive Cancer Center, 90073, USA. rbatra@ucla.edu
Sharma
S
S
Dubinett
S M
SM