"Low-dose" recombinant activated factor VII results in less blood and blood product use in traumatic hemorrhage.
BACKGROUND
This study was designed to compare mortality and blood product use in patients who received recombinant activated factor VII (rFVIIa) for traumatic hemorrhage to a matched historic control.


METHODS
Trauma registry data of bleeding trauma patients who received rFVIIa (40 microg/kg, repeated once if needed) included 28-day mortality; pre- and post-rFVIIa international normalized ratio; and packed red blood cell (PRBC), fresh frozen plasma, platelet, and cryoprecipitate requirements. A control group was created of bleeding patients who did not receive rFVIIa by matching for Injury Severity Score and age. The chi2 and Student's t tests were used to test for significance.


RESULTS
Twenty-nine patients, well matched to 72 control patients, made up the rFVIIa group. rFVIIa corrected international normalized ratio within 4 hours (from 4.4 to 1.2; p < 0.0001). There was no difference in mortality (control, 40.3%; rFVIIa, 41.4%). The rFVIIa group required significantly fewer PRBC transfusions than the control group (18.3 +/- 7.5 vs. 22.0 +/- 9.7; p = 0.036). Compared with the control group, the rFVIIa group required fewer platelet transfusions (1.4 +/- 1.2 vs. 2.3 +/- 2.1; p = 0.01) and less cryoprecipitate (0.59 +/- 0.54 vs. 1.5 +/- 1.8; p = 0.006).


CONCLUSIONS
rFVIIa resulted in significantly less PRBC, platelet, and cryoprecipitate use and equivalent mortality when compared with the matched control group, with no increase in complications.
Harrison
T Daniel
TD
Department of Surgery, Lehigh Valley Hospital, Allentown, Pennsylvania 18105-1556, USA. sally.lutz@lvh.com
Laskosky
Jason
J
Jazaeri
Omid
O
Pasquale
Michael D
MD
Cipolle
Mark
M
D000328:Adult; D001803:Blood Transfusion / Q000706:statistics & numerical data; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005167:Factor VII / Q000627:therapeutic use*; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015601:Injury Severity Score; D019934:International Normalized Ratio; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D012042:Registries; D016896:Treatment Outcome; D014949:Wounds, Nonpenetrating / Q000150:complications*
D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa