The chemokine CXCL13 (BLC): a putative diagnostic marker for neuroborreliosis.
Using protein expression profiling, the authors identified an upregulation of the chemokine B lymphocyte chemoattractant (BLC) in the CSF of patients with neuroborreliosis but not in patients with noninflammatory and various other inflammatory neurologic diseases. This upregulation was confirmed by ELISA, showing increased BLC levels in every neuroborreliosis patient while being undetectable in patients with noninflammatory neurologic diseases. These results point to BLC as a putative additional diagnostic marker for neuroborreliosis.
Rupprecht
T A
TA
Department of Neurology, Ludwig-Maximilians University, Munich, Germany.
Pfister
H W
HW
Angele
B
B
Kastenbauer
S
S
Wilske
B
B
Koedel
U
U
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000276:immunology*; D054382:Chemokine CXCL13; D019743:Chemokines, CXC / Q000134:cerebrospinal fluid* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology; D009443:Neuritis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D040081:Protein Array Analysis; D015854:Up-Regulation / Q000276:immunology
D000906:Antibodies; D015415:Biomarkers; C110663:CXCL13 protein, human; D054382:Chemokine CXCL13; D019743:Chemokines, CXC