Tensides from the group of propylene oxide and ethylene oxide copolymers. X. Solubilization of acetylsalicylic acid by polyetherodiol micelles.
The process of structural solubilization of acetylsalicylic acid in balanced systems (weight-balanced) by micelles of Rokopols of 30p160 and 30p60 types and, for comparison, by those of F-68 and F-108 Pluronics was investigated. The determined viscosity and hydrodynamic parameters allowed for the calculation of solubilizing activity of polyetherodiol micelles--n(s(A)). The results of the investigation point at Rokopols as an excipient, which may help to obtain new drug delivery systems.
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Department of Physical Chemistry, Institute of Chemistry, Faculty of Pharmacy, Scholl of Medicine, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001241:Aspirin / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers; D004852:Epoxy Compounds / Q000737:chemistry; D004987:Ethers / Q000737:chemistry* / Q000493:pharmacokinetics; D005027:Ethylene Oxide / Q000737:chemistry; D008823:Micelles; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry* / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004852:Epoxy Compounds; D004987:Ethers; D008823:Micelles; D011108:Polymers; D013501:Surface-Active Agents; D005027:Ethylene Oxide; D001241:Aspirin; C009068:propylene oxide