Regional cerebral blood flow in a patient with Nasu-Hakola disease.
We report a functional neuroimaging study of a 43-year-old woman with Nasu-Hakola disease (NHD). Regional cerebral blood flow (rCBF) images were measured with technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT). rCBF was decreased in the bilateral frontal lobes and thalamus. This finding was consistent with the known underlying neuropathology in patients with NHD. Brain SPECT is useful for demonstrating the pathophysiologic brain region in patients with NHD.
Takeshita
Tohru
T
Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. tohru@med.teikyo-u.ac.jp
Kaminaga
Tatsuro
T
Tatsumi
Tomoko
T
Hatanaka
Yuki
Y
Furui
Shigeru
S
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D025063:Chromosome Disorders / Q000000981:diagnostic imaging; D003545:Cysteine / Q000031:analogs & derivatives; D015140:Dementia, Vascular / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000151:congenital / Q000000981:diagnostic imaging*; D008569:Memory Disorders / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010009:Osteochondrodysplasias / Q000151:congenital / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013577:Syndrome
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine