Expression of neuronal nuclear antigen (NeuN) in epithelial neuroendocrine carcinoma.
Expression of neuronal nuclei (NeuN), a mouse-derived neuronal-specific monoclonal antibody, has been found in almost all neuronal cell types throughout the nervous system. The authors have demonstrated NeuN immunoreactivity in 56% of epithelial neuroendocrine carcinomas (ENEC) (19/34): 4 of 7 (57%) grade 1 ENECs (carcinoid), 4 of 5 (90%) grade 2 ENECs (atypical carcinoid), and 11 of 22 (50%) grade 3 ENECs (small and large cell neuroendocrine carcinoma). Of the NeuN-positive cases, the immunoreactivity was localized primarily in the cytoplasm in 11 cases and in the nucleus in the remaining. Even though NeuN is not a highly sensitive marker for solo use, it would be useful as an adjunct in the panel immunohisto- chemistry of cases with histologic features suspicious of neuroendocrine differentiation.
Shuangshoti
Shanop
S
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. trcssh@md.chula.ac.th
Mujananon
Sukrutai
S
Chaipipat
Mookda
M
Keetacheeva
Kanista
K
Shuangshoti
Somruetai
S
D034961:Antigens, Nuclear / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry* / Q000175:diagnosis / Q000473:pathology*; D002467:Cell Nucleus / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D009419:Nerve Tissue Proteins / Q000032:analysis*; D014018:Tissue Distribution
D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins; C506808:neuronal nuclear antigen NeuN, human