title: Brush allodynia in hospitalized headache patients.
abstract: OBJECTIVE
  To describe the incidence and time course of dynamic mechanical allodynia (brush allodynia, BA) in an inpatient headache population.
  
  
  BACKGROUND
  Four types of cutaneous allodynia (heat, cold, static mechanical [pressure], and dynamic mechanical [brush] allodynia) can be studied in headache patients. In episodic migraineurs, the development of cutaneous allodynia heralds a change in treatment response. However, little is known about the functional significance of BA, and little is known about the frequency of any type of cutaneous allodynia among patients with chronic or more severe headache disorders. Methods.-The protocol was approved by the institutional review board of our university hospital. A total of 78 subjects were tested for allodynia on days 1, 3, and 5 of an inpatient hospital stay using a 4 x 4 folded gauze pad stroked 10 times at three bilateral sites (forehead, jaw, and forearm). Subjects were queried about the signs and symptoms of their headaches. Headache intensity was graded with a verbal 11-point scale and the intensity of allodynia was graded using a 10 cm visual analog scale.
  
  
  RESULTS
  A total of 61 patients had transformed migraine (TM). BA was present at some point during the hospitalization in 32 subjects (41%). Neither age nor duration of daily headache correlated with headache severity. Headache intensity, a history of sensory symptoms or weakness, and subjective blurred vision accompanying the headache correlated with the presence of BA (P< or = .05). Unilateral headaches were more likely to be associated with BA (P = .01), independent of headache severity. When headache was unilateral, BA was greatest ipsilateral to the headache. BA did not influence outcome as measured by length of stay or the likelihood of being discharged headache-free. The rate of decline of headache intensity and allodynia score were similar.
  
  
  CONCLUSIONS
  BA is common in hospitalized headache patients. Subjects with more severe unilateral headaches were more likely to have BA. The presence of BA did not predict treatment failure in an inpatient setting.
authors.affiliation: Department of Neurology, Thomas Jefferson University Hospital, Neurology, Philadelphia, PA 19107, USA.
authors.forename: William B
authors.initials: WB
authors.lastname: Young
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Richardson
authors.forename: Pragati
authors.initials: P
authors.lastname: Shukla
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003027:Cluster Headache / Q000503:physiopathology*; D005260:Female; D020773:Headache Disorders / Q000503:physiopathology*; D006760:Hospitalization; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D007297:Inpatients; D008137:Longitudinal Studies; D008297:Male; D010812:Physical Stimulation; D016896:Treatment Outcome