title: Effectiveness of lubrication of endotracheal tube cuff with chamomile-extract for prevention of postoperative sore throat and hoarseness.
abstract: OBJECTIVE
  To determine the efficacy of lubrication of the endotracheal tube cuff with Chamomile extract (Kamillosan M) before intubation on postoperative sore throat and hoarseness.
  
  
  METHODS
  The authors randomly assigned 161 patients ASA (American Society of Anesthesiologists) physical status I, II elective surgical, orthopedic, gynecological or urological into 2 groups. The study group received 10 puffs of total 370 mg of Chamomile extract (Kamillosan M spray) lubricated at cuff of endotracheal tube while the control group did not receive any lubrication before intubation. Standard general anesthesia with tracheal intubation was given in both groups. Sore throat and hoarseness were recorded in post anesthetic care unit and at 24 h after operation.
  
  
  RESULTS
  One hundred and sixty-one ASA physical status I, II elective surgical patients were recruited. Forty one out of 81 patients (50.6%) in the Chamomile group, scored no postoperative sore throat in the post-anesthesia care unit compared with 45 out of 80 patients (56.3%) in the control group p=0.386. Postoperative sore throat and hoarseness both in the postanesthesia care unit and at 24 h postoperation were not statistically different. There was no statistically significant relationship between sore throat or hoarseness and postoperative nausea or vomiting, ASA physical status, gender, history of smoking, grade of laryngoscopic view, number of intubation attempts, condition during intubation, use of oral airway and couching during extubation.
  
  
  CONCLUSIONS
  Lubrication of endotracheal tube cuff with Chamomile extract spray before intubation can not prevent post operative sore throat and hoarseness.
authors.affiliation: Department of Anesthesiology and Clinical Epidemiology Unit, Faculty of Medicine, Chulalongkorn University, Rama IV Rd., Pathumwan, Bangkok 10330, Thailand.
authors.forename: Somrat
authors.initials: S
authors.lastname: Charuluxananan
authors.forename: Pradthana
authors.initials: P
authors.lastname: Sumethawattana
authors.forename: Rungrat
authors.initials: R
authors.lastname: Kosawiboonpol
authors.forename: Wanna
authors.initials: W
authors.lastname: Somboonviboon
authors.forename: Thewarug
authors.initials: T
authors.lastname: Werawataganon
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006685:Hoarseness / Q000517:prevention & control; D006801:Humans; D007442:Intubation, Intratracheal; D008153:Lubrication; D008297:Male; D008875:Middle Aged; D009822:Oils, Volatile / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000517:prevention & control*; D010612:Pharyngitis / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D012717:Sesquiterpenes / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D009822:Oils, Volatile; D010936:Plant Extracts; D012717:Sesquiterpenes; C056251:Kamillosan