title: [Autofluorescence laryngoscopy in the diagnosis of laryngeal cancer--early results].
abstract: BACKGROUND
  During oncogenesis significant changes in tissue properties occur that result in alteration of fluorescence characteristics of the tissue. The aim of our study was to determine the usefulness of autofluorescence technique in diagnostic of laryngeal epithelium lesions.
  
  
  METHODS
  40 patients admitted to the Department of Otolaryngology Wroclaw Medical University due to different laryngeal lesions were included into the study. They underwent white light laryngoscopy followed by autofluorescence videoendoscopy. AF was induced by blue light of xenon short arc lamp and processed by a D-light AF System (Storz). Autofluorescence and white light images were immediately assessed and later compared with to histopathological findings.
  
  
  RESULTS
  Normal laryngeal mucosa showed a typical green fluorescence signal. Squamous cell carcinoma displayed a diminished green fluorescence and in some cases presented reddish-yellow color.
  
  
  CONCLUSIONS
  We revealed that autofluorescence laryngoscopy is very helpful, supplementary tool in diagnosis of laryngeal pathology. Autofluorescence laryngoscopy is noninvasive technique designed especially for diagnostic of early and premalignant lesions.
authors.affiliation: Klinika Otolaryngologii AM we Wrocławiu.
authors.forename: Maria
authors.initials: M
authors.lastname: Zalesska-Krecicka
authors.forename: Tomasz
authors.initials: T
authors.lastname: Krecicki
authors.forename: Marcin
authors.initials: M
authors.lastname: Fraczek
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Bereś-Pawlik
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zatoński
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005453:Fluorescence; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007828:Laryngoscopy / Q000379:methods*; D008297:Male; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity