[Protective effect of purariae isoflavone on apoptosis cells of nasal mocosas in ovariectomized rats].
OBJECTIVE
To study the protective effect of purariae isoflavone on apoptosis cells of atrophic nasal mucosas in ovariectomized rats.


METHODS
60 rats were divided into four groups as control, ovariectomized, ovariectomized + nylestriol (O + N) and ovariectomized + purariae isoflavone (O + P), each with 15 rats. Earlier apotosis cells of mucosas taken from nasal septum were measured with flow cytometry.


RESULTS
Compared with control group, and the number of apoptosis cells of mucosas increased after being ovariectomized,and the number of apoptosis cells of mucosas in O + N and O + D group didn't change.


CONCLUSIONS
Nylestriol and purariae isoflavone might have effects on protecting cells of mucosas from lacking of estrogen by decreasing apoptosis cells in ovariectomized rats.
Qi
Ben-Ming
BM
The First People's Hospital of Yunnan Province, Kunming 650001, China. qibenming@21cn.com
Cai
Chun-Chun
CC
Deng
Xiao-Ming
XM
Zhang
Lin
L
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004847:Epithelial Cells / Q000473:pathology*; D045166:Estradiol Congeners / Q000494:pharmacology; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000473:pathology*; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D029908:Pueraria / Q000737:chemistry; D011800:Quinestrol / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D045166:Estradiol Congeners; D007529:Isoflavones; D020011:Protective Agents; C010722:nylestriol; D011800:Quinestrol