Triple helicate constructed by covalent bondings: crystal structure and effective synthesis based on propeller-like substructures.
A triple helicate, having a macrocyclic aromatic amide structure, was synthesized in high yield because of a preorganized component of the tertiary benzenetrianilide moieties in a propeller-like syn conformation at both ends. The helicity was derived from tilted T-shaped aromatic-aromatic (CH-pi) interactions between each of the N-phenyl rings. [structure: see text]
Tominaga
Masahide
M
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.
Masu
Hyuma
H
Katagiri
Kosuke
K
Kato
Takako
T
Azumaya
Isao
I