Role of cytokine polymorphisms in the risk of distal gastric cancer development.
We review the current information concerning the role of cytokine polymorphisms and the risk of develop distal gastric cancer in different populations. We have included populations colonized with Helicobacter pylori as well as populations without colonization. We found that the study of polymorphisms alone seems insufficient to assess gastric cancer risk and it is necessary to examine environmental factors in different ethnic groups and geographic areas along with the study of H. pylori strains to define better the risk factors associated with distal gastric cancer.
Perez-Perez
Guillermo I
GI
Department of Medicine and Microbiology, New York University School of Medicine and Veterans Affairs Medical Center, 423 East 23rd Street, New York, NY 10010, USA. perezg02@med.nyu.edu
Garza-Gonzalez
Elvira
E
Portal
Cynthia
C
Olivares
Asalia Z
AZ
D016022:Case-Control Studies; D005260:Female; D005828:Genetics, Population; D005838:Genotype; D016480:Helicobacter pylori / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000502:physiology
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha