title: [Polymorphism of apolipoprotein E gene and natural longevity in the Xinjiang Uighur people: an association study].
abstract: OBJECTIVE
  To explore the distribution of polymorphisms of apolipoprotein E(apoE) gene and its relation to natural longevity in the Xinjiang Uighur people.
  
  
  METHODS
  Using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP), the authors obtained data from centenarians(n=42), 90-year-old people (n=102), 65-70-year-old people (n=70) and controls(n=53).
  
  
  RESULTS
  The frequencies of apoE genotypes epsilon 3/4, epsilon 3/3 and epsilon 2/3 were 2.4%, 69.0% and 23.8% respectively in the centenarian group, and the frequencies of their epsilon 4, epsilon 3 and epsilon 2 alleles were 1.2%, 82.1% and 16.7%. The frequencies of genotype epsilon 3/4 and epsilon 4, epsilon 3 allele in the centenarian group were significantly lower than those in controls(P< 0.01), whereas the frequencies of genotype epsilon 2/3 and epsilon 2 allele in the centenarian group were significantly higher than those in controls(P< 0.01). Longevity was noted to be positively correlated with epsilon 2 and negatively correlated with epsilon 4.
  
  
  CONCLUSIONS
  This relationship reflects a genetic influence on differential survival and may point to pleiotropic age-dependent effects on longevity.
authors.affiliation: Cardiology Department of Internal Medicine, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830054 PR China. mayilawu@medmail.com.cn
authors.forename: Wufuer
authors.initials: W
authors.lastname: Mayila
authors.forename: Ming-wu
authors.initials: MW
authors.lastname: Fang
authors.forename: Zu-heng
authors.initials: ZH
authors.lastname: Cheng
authors.forename: Chang-chun
authors.initials: CC
authors.lastname: Qiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D001057:Apolipoproteins E