Renal leiomyoma associated with Epstein-Barr virus in a pediatric transplant patient.
Renal leiomyoma is a rare smooth muscle tumor of the kidney. An association between Epstein-Barr virus and smooth muscle tumors in immunocompromised patients recently has been recognized. We describe a pediatric renal transplant patient who developed an Epstein-Barr virus-associated renal leiomyoma in his transplant kidney 5 years posttransplantation. Possible factors involved in the tumor pathogenesis in our patient are discussed, including immunosuppression, growth hormone therapy, and Epstein-Barr virus induction.
Dionne
Janis M
JM
Division of Pediatric Nephrology, Department of Pathology, British Columbia's Children's Hospital, Vancouver, British Columbia, Canada. jdionne@cw.bc.ca
Carter
James E
JE
Matsell
Douglas
D
MacNeily
Andrew E
AE
Morrison
Kevin B
KB
de Sa
Derek
D
D002675:Child, Preschool; D018562:Disease Transmission, Infectious; D020031:Epstein-Barr Virus Infections / Q000635:transmission*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D006869:Hydronephrosis / Q000150:complications; D007668:Kidney / Q000002:abnormalities / Q000737:chemistry / Q000473:pathology / Q000821:virology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000821:virology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D009395:Nephritis, Interstitial / Q000209:etiology; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D011859:Radiography; D012008:Recurrence; D006435:Renal Dialysis; D014184:Transplantation, Homologous / Q000009:adverse effects*; D014463:Ultrasonography; D014521:Urethra / Q000002:abnormalities; D014552:Urinary Tract Infections / Q000209:etiology
D012367:RNA, Viral