title: 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.
abstract: A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A(1)AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A(2A)AR.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, via Bonanno 6, 56126 Pisa, Italy. manera@farm.unipi.it
authors.forename: Clementina
authors.initials: C
authors.lastname: Manera
authors.forename: Laura
authors.initials: L
authors.lastname: Betti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Cavallini
authors.forename: Gino
authors.initials: G
authors.lastname: Giannaccini
authors.forename: Adriano
authors.initials: A
authors.lastname: Martinelli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Ortore
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Saccomanni
authors.forename: Letizia
authors.initials: L
authors.lastname: Trincavelli
authors.forename: Tiziano
authors.initials: T
authors.lastname: Tuccinardi
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Ferrarini
mesh_terms: D000818:Animals; D002417:Cattle; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009287:Naphthyridines / Q000378:metabolism*; D043705:Receptor, Adenosine A2A / Q000378:metabolism*
chemical_list: D009287:Naphthyridines; D043705:Receptor, Adenosine A2A