title: Transcriptional interference mediated by retrotransposons within the genome of their host: lessons from alleles of the white gene from Drosophila melanogaster.
abstract: Systematic sequencing of model genomes has accelerated our knowledge on genome structure and shown that a large proportion of intergenic regions are made up of mobile element families. Among them, retrotransposons that are mobilized via an RNA intermediate and thus do not excise during their replication cycle are certainly essential factors able to imprint novel and heritable transcriptional regulation within the genome of their host. Today, a crucial complement to the systematic sequencing data is thus to elucidate the potential role of these elements in the regulation of nearby genes, and ultimately in the evolution of eukaryotic genomes.
authors.affiliation: INSERM U384, Faculté de Médecine, Clermont-Ferrand, France.
authors.forename: S
authors.initials: S
authors.lastname: Desset
authors.forename: Ch
authors.initials: Ch
authors.lastname: Vaury
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D016678:Genome; D008957:Models, Genetic; D018626:Retroelements; D014158:Transcription, Genetic
chemical_list: D004251:DNA Transposable Elements; D018626:Retroelements