title: Catalytic asymmetric synthesis with rh-diene complexes: 1,4-addition of arylboronic acids to unsaturated esters.
abstract: A general route to enantioenriched tert-butyl 3,3-diarylpropanoates is presented. These useful building blocks are prepared via an asymmetric rhodium-catalyzed conjugate addition of arylboronic acids to unsaturated tert-butyl esters in the presence of chiral dienes as ligands. The addition of both electron-poor and electron-rich boronic acids proceeds smoothly with various enoates in 63-90% yield with high enantioselectivites (89-94% ee). [reaction: see text]
authors.affiliation: Laboratorium für Organische Chemie, ETH Hönggerberg, HCI H335, 8093 Zürich, Switzerland.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Paquin
authors.forename: Corey R J
authors.initials: CR
authors.lastname: Stephenson
authors.forename: Christian
authors.initials: C
authors.lastname: Defieber
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira