title: Retinoids as therapeutic agents: today and tomorrow.
abstract: Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.
authors.affiliation: ALIX, Bio-Incubateur de l'ESBS, Boulevard Sebastien Brandt, 67400 Illkirch, France. vivat@alix-pharma.fr
authors.forename: Valerie
authors.initials: V
authors.lastname: Vivat-Hannah
authors.forename: F Christopher
authors.initials: FC
authors.lastname: Zusi
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004304:Dosage Forms; D004347:Drug Interactions; D006801:Humans; D023421:Models, Animal; D009369:Neoplasms / Q000188:drug therapy*; D012176:Retinoids / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D004304:Dosage Forms; D012176:Retinoids; D014157:Transcription Factors