Total synthesis of scutellarin-7-O-glucuronide.
Scutellarin-7-O-glucuronide (1) has been synthesized from 2-hydroxyl-4,5,6-trimethoxyacetophenone through eight steps, including Michael addition, cyclization, hydrogenation, hydroxyl protection, deprotection, etc. The overall yield of 13% is much higher than that reported (0.6%) by L. Farkas, G. Mezey-Vàndor et al. in 1974.
Cui
Jian-Mei
JM
Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
Fang
Gang
G
Duan
Ya-Bo
YB
Liu
Qian
Q
Wu
Li-Ping
LP
Zhang
Guo-Hong
GH
Wu
Song
S
D000098:Acetophenones / Q000737:chemistry; D019659:Asteraceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry; D006865:Hydrogenation
C504842:2-hydroxyl-4,5,6-trimethoxyacetophenone; D000098:Acetophenones; D047309:Flavones; C504841:scutellarin-7-O-glucuronide