Comparison between sequence analysis and a line probe assay for testing genotypic resistance of human immunodeficiency virus type 1 to antiretroviral drugs.
The purpose of this study was to compare a line probe assay (LiPA) with sequence analysis for the detection of mutations conferring resistance to nucleoside and non-nucleoside inhibitors in human immunodeficiency reverse transcriptase and protease inhibitors. The limitations for interpreting LiPA make it unacceptable for routine clinical practice.
García-Bujalance
S
S
Department of Microbiology and Parasitology, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain. sgarciab.hulp@salud.madrid.org
de Guevara
C Ladrón
CL
González-García
J
J
Arribas
J R
JR
Gutiérrez
A
A
D019380:Anti-HIV Agents / Q000494:pharmacology*; D001483:Base Sequence; D024882:Drug Resistance, Viral; D005838:Genotype; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
D019380:Anti-HIV Agents