title: Microcoil nuclear magnetic resonance spectroscopy.
abstract: In comparison with most analytical chemistry techniques, nuclear magnetic resonance has an intrinsically low sensitivity, and many potential applications are therefore precluded by the limited available quantity of certain types of sample. In recent years, there has been a trend, both commercial and academic, towards miniaturization of the receiver coil in order to increase the mass sensitivity of NMR measurements. These small coils have also proved very useful in coupling NMR detection with commonly used microseparation techniques. A further development enabled by small detectors is parallel data acquisition from many samples simultaneously, made possible by incorporating multiple receiver coils into a single NMR probehead. This review article summarizes recent developments and applications of "microcoil" NMR spectroscopy.
authors.affiliation: Department of Electrical and Computer Engineering, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 4221 Beckman Institute, 405 N. Mathews, Urbana, IL 61801, USA. agwebb@uiuc.edu
authors.forename: A G
authors.initials: AG
authors.lastname: Webb
mesh_terms: D008904:Miniaturization; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000295:instrumentation / Q000379:methods*; D011506:Proteins / Q000032:analysis; D012680:Sensitivity and Specificity
chemical_list: D011506:Proteins