Leptin regulates energetic tradeoffs between body fat and humoural immunity.
Mounting an immune response requires a relatively substantial investment of energy and marked reductions in energy availability can suppress immune function and presumably increase disease susceptibility. We have previously demonstrated that a moderate reduction in energy stores via partial surgical lipectomy (LIPx) impairs humoural immunity of Siberian hamsters (Phodopus sungorus). Here we tested the hypothesis that LIPx-induced decreases in immunity are mediated by changes in the adipose tissue hormone leptin. Hamsters received bilateral surgical removal of inguinal white adipose tissue (IWATx) or sham surgeries (Sham). Half the animals in each group received osmotic minipumps containing murine leptin (0.5mulh-1 for 10 days) whereas the remaining animals received minipumps containing vehicle alone; all animals were subsequently challenged with the novel antigen keyhole limpet haemocyanin (KLH). In general, serum leptin and anti-KLH antibodies were significantly correlated with one another with higher levels generally indicating enhanced immunity. In addition, IWATx hamsters had significantly lower serum anti-KLH IgG compared with sham animals. Exogenous leptin, however, attenuated LIPx-induced immune suppression but did not affect humoural immunity in sham animals. These results suggest that reductions in energy availability lead to impairments in humoural immunity and that leptin can serve as a neuroendocrine signal between body fat and immunity regulating humoural immune responses.
Demas
Gregory E
GE
Program in Neural Science and Center for the Integrative Study of Animal Behavior and Department of Biology, Indiana University, Bloomington, IN 47405 USA. gdemas@bio.indiana.edu
Sakaria
Sangeeta
S
D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology*; D006224:Cricetinae; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006433:Hemocyanins; D007074:Immunoglobulin G / Q000097:blood; D020738:Leptin / Q000097:blood / Q000276:immunology* / Q000494:pharmacology; D017111:Phodopus
D000906:Antibodies; D007074:Immunoglobulin G; D020738:Leptin; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin