Clinical trials targeting lung cancer with active immunotherapy: the scope of vaccines.
Successful active immunotherapy is expected to be specific and nontoxic. Until now, the success of immunotherapy in cancer has been sporadic and unpredictable. This has been attributable in part to the lack of a full understanding of the mechanistic underpinnings of immune regulation. Furthermore, the lack of systematic success of immunotherapy, as argued in this review, stems from failing to effectively target tumors such as non-small cell lung cancer. In this review, the rationale and design for induction of immunity to non-small cell lung cancer and clinical trials of the most important lung cancer vaccines in development are discussed.
Raez
Luis E
LE
Division of Hematology-Oncology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, 1475 NW 12 Avenue, Miami, FL 33136, USA. lraez@med.miami.edu
Santos
Edgardo S
ES
Mudad
Raja
R
Podack
Eckhard R
ER
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000276:immunology*; D002986:Clinical Trials as Topic; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D008264:Macrophages; D013601:T-Lymphocytes
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines