title: Chromosomics.
abstract: The term "chromosomics" is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner during the cell cycle. It also deals with species-specific differences in the architecture of chromosomes, which has been overlooked in the past. Chromosomics includes research into chromatin-modification-mediated changes in the architecture of chromosomes, which may influence the functions and life-spans of cells, tissues, organs and individuals. It also addresses the occurrence and prevalence of chromosomal gaps and breaks.
authors.affiliation: Institute of Human Genetics and Anthropology, Jena, Germany. ucla@mti.uni-jena.de
authors.forename: U
authors.initials: U
authors.lastname: Claussen
mesh_terms: D002875:Chromosomes / Q000235:genetics* / Q000648:ultrastructure*; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure; D003582:Cytogenetics / Q000639:trends; D006801:Humans