Directed ortho lithiation of N-alkylphenylaziridines.
The ortho lithiation-trapping sequence of phenylaziridines is described. This methodology, which counts on the ability of the aziridino group to act as a directed metalation group (DMG), provides an easy access to functionalized arylaziridines as well as to phthalans and phthalides. The importance of the aziridine N-substituent in this DoM reaction is stressed as well. [reaction: see text]
Capriati
Vito
V
Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, I-70126 Bari, Italy.
Florio
Saverio
S
Luisi
Renzo
R
Musio
Biagia
B