Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.
Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 microM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 microM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.
Mosel
Daniel D
DD
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0666, USA.
Dumitru
Raluca
R
Hornby
Jacob M
JM
Atkin
Audrey L
AL
Nickerson
Kenneth W
KW
D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005204:Farnesol / Q000494:pharmacology*; D007700:Kinetics; D044967:Serum / Q000378:metabolism*
D003470:Culture Media; D005204:Farnesol