title: Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV.
abstract: Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. Here, CaMKIV knockout mice (CaMKIV(-/-)) were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIV(-/-) exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV(-/-) mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. fanny.shum@utoronto.ca
authors.forename: Fanny W F
authors.initials: FW
authors.lastname: Shum
authors.forename: Shanelle W
authors.initials: SW
authors.lastname: Ko
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Lee
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
mesh_terms: D000698:Analgesia; D000818:Animals; D001007:Anxiety / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D001522:Behavior, Animal; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4 / Q000172:deficiency* / Q000378:metabolism; D003624:Darkness; D005106:Exploratory Behavior; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010121:Oxytocin / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013216:Reflex, Startle / Q000235:genetics; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D013550:Swimming
chemical_list: D012333:RNA, Messenger; D010121:Oxytocin; D054734:Calcium-Calmodulin-Dependent Protein Kinase Type 4