A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections.
Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively). We conducted a prospective study of URI and LRI in adults with hematologic malignancies during a 4-year period. We retrospectively tested samples by reverse-transcription polymerase chain reaction for hMPV and analyzed clinical data. Twenty-two (9%) of 251 episodes of respiratory infection tested positive for hMPV. Sixteen (73%) of the illnesses occurred in hematopoietic stem-cell transplant recipients. Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality.
Williams
John V
JV
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2581, USA. john.williams@vanderbilt.edu
Martino
Rodrigo
R
Rabella
Núria
N
Otegui
Magdalena
M
Parody
Rocio
R
Heck
Joshua M
JM
Crowe
James E
JE
D000328:Adult; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D029121:Metapneumovirus / Q000302:isolation & purification*; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000150:complications / Q000401:mortality / Q000821:virology*; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000150:complications / Q000401:mortality / Q000821:virology*