Lysophospholipids in the nervous system.
This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics: Signaling Lipids and Drugs of Abuse" held in Washington, D.C., 15-17 April 2004, organized by Dr. Rao Rapaka. Lysophospholipids represent one class of lipids that has many important actions mediated by G protein-coupled receptors. While influencing a large number of biologically important systems, this discussion will focus on the nervous system, including areas of future research.
Chun
Jerold
J
Department of Molecular Biology, The Helen L, Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND-118, La Jolla, CA 92037, USA. jchun@scripps.edu
D000818:Animals; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000737:chemistry; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D009420:Nervous System / Q000378:metabolism*; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism
D008055:Lipids; D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine; C032881:lysophosphatidic acid