Podocyte biology in human disease.
The podocyte is a highly specialized cell that plays a key role in regulating the glomerular filtration barrier. A number of advances have been made in recent years, linked to the discovery of single-gene defects in hereditary glomerular disease, which highlight the role of this cell in preventing proteinuria. This article reviews the molecular biology of the podocyte, focusing on known genetic abnormalities.
de Zoysa
Janak Rashme
JR
Department of Renal Medicine, Auckland City Hospital, Auckland, New Zealand. janakz@adhb.govt.nz
Topham
Peter Stewart
PS
D002453:Cell Cycle; D003599:Cytoskeleton / Q000502:physiology; D005374:Filtration; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D007678:Kidney Glomerulus / Q000196:embryology / Q000378:metabolism; D009024:Morphogenesis; D050199:Podocytes / Q000166:cytology / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D042461:Vascular Endothelial Growth Factor A