Paralogs and mutational robustness linked through transcriptional reprogramming.
A recent analysis of genome-wide expression patterns and regulatory motif content of paralogous yeast genes strongly suggests that mutational robustness (backup) between paralogous genes is achieved via transcriptional reprogramming of one paralog to compensate for the loss or silencing of the other.
Koonin
Eugene V
EV
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda MD 20894, USA. koonin@ncbi.nlm.nih.gov
D019143:Evolution, Molecular; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*