title: Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats.
abstract: Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased following treatment with maternal alcohol in a dose-dependent fashion. The present results suggest that suppression of NOS expression in the hippocampus of offspring rats with maternal alcohol mediates the associated developmental retardation and/or anomalies.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea.
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Myoung-Hwa
authors.initials: MH
authors.lastname: Lee
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Sam-Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Young-Je
authors.initials: YJ
authors.lastname: Sim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
authors.forename: Se-Keun
authors.initials: SK
authors.lastname: Park
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D002492:Central Nervous System Depressants / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D006624:Hippocampus / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000199:Actins; D002492:Central Nervous System Depressants; D012333:RNA, Messenger; D000431:Ethanol; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase