A review of the mechanisms implicated in the pathogenesis of the diabetic foot.
The developmental pathway toward diabetic foot ulceration is best described as multifactorial. A critical triad of neuropathy, minor foot trauma, and foot deformity has been identified in greater than 63% of foot ulcers. In addition to these risk factors, increased peak plantar pressures, autonomic and motor neuropathy, limited joint mobility, and impaired wound healing contribute to the formation of diabetic foot ulcers. It is essential to understand the pathogenesis of foot ulcers so that appropriate treatments may be developed.
Dinh
Thanh L
TL
Division of Podiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Veves
Aristidis
A
D017719:Diabetic Foot / Q000209:etiology*; D003929:Diabetic Neuropathies / Q000150:complications; D018450:Disease Progression; D016523:Foot Ulcer / Q000209:etiology; D006801:Humans; D012039:Regional Blood Flow / Q000502:physiology; D012307:Risk Factors