title: The influence of environment on development of the mucosal immune system.
abstract: The mucosal immune system expresses active responses against pathogens and also tolerance against harmless food and commensal bacterial antigens. The mechanisms that determine which of these outcomes occur after recognition of antigens by T-cells are not clear. One possibility is that it is determined by the initial interaction between a dendritic and a naïve T-cell in organised lymphoid tissue. However, such organised structures are, evolutionarily, quite recent and the original immune system must have made appropriate responses in more diffuse immunological architecture; a second possibility is that the critical interaction is between primed T-cells and their environment, in the lamina propria of the intestine. The mucosal immune system of neonates is poorly developed and inefficient at expressing appropriate immune responses. Development is influenced by a range of environmental factors including maternally derived antigen or antibody and commensal flora and pathogens. The intestine is a complex immunological structure in which the immune system and the macro- and microenvironment interact.
authors.affiliation: School of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU, UK. mick.bailey@bristol.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Bailey
authors.forename: K
authors.initials: K
authors.lastname: Haverson
authors.forename: C
authors.initials: C
authors.lastname: Inman
authors.forename: C
authors.initials: C
authors.lastname: Harris
authors.forename: P
authors.initials: P
authors.lastname: Jones
authors.forename: G
authors.initials: G
authors.lastname: Corfield
authors.forename: B
authors.initials: B
authors.lastname: Miller
authors.forename: C
authors.initials: C
authors.lastname: Stokes
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017951:Antigen Presentation; D003713:Dendritic Cells / Q000276:immunology; D004777:Environment; D005260:Female; D007107:Immune System / Q000254:growth & development*; D007108:Immune Tolerance; D007112:Immunity, Maternally-Acquired; D018928:Immunity, Mucosal; D008221:Lymphoid Tissue / Q000254:growth & development / Q000276:immunology; D018448:Models, Immunological; D011247:Pregnancy; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology