[Photodynamic inhibition of infection caused by herpes simplex virus type 1 in the cultured cells, by using 5-aminolevulinic acid-induced porphyrins].
On simulating infection caused by different herpes simplex virus type 1 (HSV-1) variants responsive and unresponsive to the drugs acyclovir and phosphonoacetic acid in the cultured Vero and C6 cells has revealed the higher ability of target cells to accumulate 5-aminolevulenic acid (ALA)-induced endogenous porphyrins, which determines the selectivity of their photo damages. Optimal conditions have been defined for all the studied HSV-1 variants to show a virus-inhibiting effect upon photodynamic exposure of infected and ALA-treated cell cultures.
Kvacheva
Z B
ZB
Lobanok
E S
ES
Votiakov
V I
VI
Shukanova
N A
NA
Vorobeĭ
A V
AV
Nikolaeva
S N
SN
Titov
L P
LP
D000622:Aminolevulinic Acid / Q000494:pharmacology*; D000818:Animals; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000188:drug therapy / Q000503:physiopathology*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000096:biosynthesis*; D051381:Rats; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects* / Q000528:radiation effects*
D017319:Photosensitizing Agents; D011166:Porphyrins; D000622:Aminolevulinic Acid