[Stress proteins in Alzheimer's disease].
Alzheimer's disease (AD) progression can be restricted by brain self-defense systems for a long time since the onset. Among these an exclusive role is played by the system of stress proteins, or heat shock proteins. In AD, stress proteins play primarily a neuroprotective role, which is realized through at least 7 mechanisms: 1) restriction of apoptosis; 2) restriction of NO overproduction; 3) disaggregation of extracellular Abeta aggregates; 4) acceleration of Abeta elimination from intercellular space; 5) restriction of tau-protein hyperphosphorylation; 6) protection of neurons from glutamate toxicity; 7) restriction of intracellular Abeta cytotoxicity. Results of studies on protective effects of heat shock proteins in AD allow creation of a new trend in the field of the treatment, related with developing methods of activation of stress protein self-defense system in order to restrict neurodegenerative disorders. The given review presents theoretical and experimental prerequisites for such an approach, and substantiates its possible efficiency.
Malyshev
I Iu
IIu
Manukhina
E B
EB
D000544:Alzheimer Disease / Q000097:blood* / Q000473:pathology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D018450:Disease Progression; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans
D006360:Heat-Shock Proteins