title: LRP 1 B functions as a receptor for Pseudomonas exotoxin.
abstract: Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor.
authors.affiliation: Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, MD 20892-4263, USA.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Pastrana
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Hanson
authors.forename: Jane
authors.initials: J
authors.lastname: Knisely
authors.forename: Guojun
authors.initials: G
authors.lastname: Bu
authors.forename: David J
authors.initials: DJ
authors.lastname: Fitzgerald
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000633:toxicity; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004591:Electrophoresis, Polyacrylamide Gel; D018014:Gene Transfer Techniques; D008567:Membranes, Artificial; D009154:Mutation / Q000235:genetics; D011145:Polyvinyls; D011485:Protein Binding / Q000187:drug effects; D011500:Protein Synthesis Inhibitors / Q000378:metabolism* / Q000633:toxicity; D011973:Receptors, LDL / Q000378:metabolism*; D018675:Toxicity Tests; D005465:Fluorocarbon Polymers
chemical_list: D001426:Bacterial Proteins; D008567:Membranes, Artificial; D011145:Polyvinyls; D011500:Protein Synthesis Inhibitors; D011973:Receptors, LDL; C434476:LRP1B protein, human; C111749:pseudomonas exoprotein A protein, Pseudomonas aeruginosa; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers