title: Leukocytoclastic vasculitis: a rare manifestation of propylthiouracil hypersensitivity.
abstract: OBJECTIVE
  We report a case of leukocytoclastic vasculitis as a manifestation of propylthiouracil hypersensitivity.
  
  
  METHODS
  A 66-year-old woman with a history of a toxic adenoma was referred for evaluation of a purpuric rash on the legs and buttocks bilaterally. She was biochemically hyperthyroid. Biopsy of the skin lesions revealed leukocytoclastic vasculitis. Propylthiouracil therapy was discontinued, and methimazole started. The purpuric rash resolved and surgical treatment for toxic adenoma resulted in euthyroid state.
  
  
  CONCLUSIONS
  This report indicated that leukocytoclastic vasculitis should be considered in the differential diagnosis of patients with a vasculitic rash. The discontinuation of the propylthiouracil was associated with disappearance of the lesions.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. cihangirerem@hotmail.com
authors.forename: Cihangir
authors.initials: C
authors.lastname: Erem
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yucel
authors.forename: Ziya
authors.initials: Z
authors.lastname: Ya
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Reis
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kocak
authors.forename: Arif
authors.initials: A
authors.lastname: Hacihasanoglu
mesh_terms: D000236:Adenoma / Q000150:complications / Q000188:drug therapy; D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005076:Exanthema / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006044:Goiter, Nodular / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy; D008713:Methimazole / Q000627:therapeutic use; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole; D011441:Propylthiouracil