Decreased prevalence of virulence factors among ciprofloxacin-resistant uropathogenic Escherichia coli isolates.
Ciprofloxacin resistance was identified in 18% and 6% of consecutively collected, clinically significant urinary tract isolates of Escherichia coli from inpatients and outpatients, respectively. In comparison to ciprofloxacin-susceptible isolates, there were fewer resistant isolates that expressed beta-hemolysis (outpatient, 9% versus 87%, P < 0.0001; inpatient, 4% versus 76%, P < 0.0001) and that had a papEF genotype, genes encoding P fimbriae (outpatient, 30% versus 70%, P = 0.0004; inpatient, 26% versus 70%, P < 0.0001).
Drews
S J
SJ
Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
Poutanen
S M
SM
Mazzulli
T
T
McGeer
A J
AJ
Sarabia
A
A
Pong-Porter
S
S
Rzayev
Y
Y
Willey
B
B
Green
K
K
Low
D E
DE
D001437:Bacteriuria / Q000382:microbiology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000472:pathogenicity*; D006461:Hemolysis; D006801:Humans; D009268:Nalidixic Acid / Q000494:pharmacology; D037521:Virulence Factors / Q000032:analysis*
D037521:Virulence Factors; D009268:Nalidixic Acid; D002939:Ciprofloxacin