RNA turnover: unexpected consequences of being tailed.
In eukaryotic cells, the 3' poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3' end poly(A) tails in the nuclear surveillance and turnover of noncoding RNAs and intergenic mRNAs of unknown function.
Anderson
James T
JT
Department of Biological Sciences, Marquette University, PO Box 1881, Milwaukee, Wisconsin 53201, USA.
D005057:Eukaryotic Cells / Q000502:physiology*; D008957:Models, Genetic; D046912:Multiprotein Complexes / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000378:metabolism*; D039104:RNA 3' Polyadenylation Signals / Q000235:genetics / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics / Q000502:physiology*; D020871:RNA Stability / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
D046912:Multiprotein Complexes; D012333:RNA, Messenger; D009713:Nucleotidyltransferases