title: A graphical approach for evaluating effective connectivity in neural systems.
abstract: The identification of effective connectivity from time-series data such as electroencephalogram (EEG) or time-resolved function magnetic resonance imaging (fMRI) recordings is an important problem in brain imaging. One commonly used approach to inference effective connectivity is based on vector autoregressive models and the concept of Granger causality. However, this probabilistic concept of causality can lead to spurious causalities in the presence of latent variables. Recently, graphical models have been used to discuss problems of causal inference for multivariate data. In this paper, we extend these concepts to the case of time-series and present a graphical approach for discussing Granger-causal relationships among multiple time-series. In particular, we propose a new graphical representation that allows the characterization of spurious causality and, thus, can be used to investigate spurious causality. The method is demonstrated with concurrent EEG and fMRI recordings which are used to investigate the interrelations between the alpha rhythm in the EEG and blood oxygenation level dependent (BOLD) responses in the fMRI. The results confirm previous findings on the location of the source of the EEG alpha rhythm.
authors.affiliation: Department of Statistics, The University of Chicago, Chicago, IL 60637, USA. eichler@statlab.uni-heidelberg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Eichler
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008390:Markov Chains; D008959:Models, Neurological; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen