title: Therapeutic role of mitoxantrone in multiple sclerosis.
abstract: Mitoxantrone is approved by several health authorities for treatment of active forms of relapsing-remitting or secondary progressive multiple sclerosis (SPMS). This review provides an outline on relevant preclinical as well as clinical studies, places mitoxantrone in the context of other therapeutic approaches against multiple sclerosis (MS), and discusses relevant side effects. The current knowledge of the putative mechanisms of action of the compound is discussed.
authors.affiliation: Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany. oliver.neuhaus@uni-duesseldorf.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Neuhaus
authors.forename: Bernd C
authors.initials: BC
authors.lastname: Kieseier
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D006801:Humans; D008942:Mitoxantrone / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology
chemical_list: D008942:Mitoxantrone