Ischemic stroke subtypes and thrombophilia in young and elderly Brazilian stroke patients admitted to a rehabilitation hospital.
OBJECTIVE
We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients.


METHODS
A total of 130 consecutive young and 200 elderly stroke patients were studied.


RESULTS
Prevalence of thrombophilia was, respectively: protein S deficiency (11.5% versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (1.5% versus 2%), antithrombin III deficiency (0% versus 0%), lupus anticoagulant (0% versus 0.5%), anticardiolipin antibodies (3% versus 10%; P=0.01), hyperhomocysteinemia (31.5% versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10% versus 5%), and heterocigosis (27.6% versus 41.9%; P=0.01).


CONCLUSIONS
Prothrombotic conditions were more frequent in stroke of undetermined cause.
Carod-Artal
Francisco Javier
FJ
Neurology Department, The Sarah Network of Rehabilitation Hospitals, Sarah Hospital, Brasilia, DF, Brazil. javier@bsb.sarah.br
Nunes
Simone Vilela
SV
Portugal
Dalton
D
Silva
Tania Virginia Fernandes
TV
Vargas
Antonio Pedro
AP
D020016:Activated Protein C Resistance / Q000097:blood; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000737:chemistry; D002545:Brain Ischemia / Q000473:pathology / Q000534:rehabilitation* / Q000628:therapy; D001938:Brazil; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006761:Hospitals; D006801:Humans; D020138:Hyperhomocysteinemia / Q000473:pathology; D016682:Lupus Coagulation Inhibitor / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies; D020151:Protein C Deficiency / Q000097:blood; D018455:Protein S Deficiency / Q000097:blood; D012046:Rehabilitation / Q000379:methods*; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D000071939:Stroke Rehabilitation; D019851:Thrombophilia / Q000150:complications*; D013927:Thrombosis
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; C095381:factor V Leiden; D005165:Factor V