title: In vitro interactions of Aspilia africana (Pers.) C.D. Adams, a traditional antimalarial medicinal plant, with artemisinin against Plasmodium falciparum.
abstract: Traditional antimalarial medicinal preparations are widely used concurrently with antimalarial drugs in malaria endemic areas. The plant Aspilia africana (Pers.) C.D. Adams is commonly used for traditional treatment of malaria symptoms in East and Central Africa. An in vitro study of interactions between an extract from this plant with artemisinin against two strains of Plasmodium falciparum showed an antagonist relationship against both the chloroquine-sensitive D10 and the chloroquine- and sulphonamide-resistant K1 strains of Plasmodium falciparum. The extract reduced accumulation of radiolabelled dihydroartemisinin ((3)H-DHA) by erythrocytes infected with the chloroquine- and sulphonamide-resistant K1 strain of Plasmodium falciparum while it increased its accumulation by erythrocytes infected with the chloroquine-sensitive D10 strain. These results suggest complex interactions between the antimalarial medicinal plant and artemisinin. This study also proposes an in vitro approach to investigating interactions between antimalarial drugs and traditional medicines.
authors.affiliation: Department of Pharmacology and Therapeutics, Makerere University, Medical School, Box 7072 Kampala, Uganda. pwaako@med.mak.ac.ug
authors.forename: P J
authors.initials: PJ
authors.lastname: Waako
authors.forename: P
authors.initials: P
authors.lastname: Smith
authors.forename: P I
authors.initials: PI
authors.lastname: Folb
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000378:metabolism / Q000494:pharmacology*; D019659:Asteraceae; D004347:Drug Interactions; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D007194:India; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D010936:Plant Extracts; D012717:Sesquiterpenes; C039060:artenimol; C031327:artemisinin