Receptor systems: will mining the receptorome yield novel targets for pharmacotherapy?
We have recently defined the receptorome as 'that part of the proteome encoding receptors'. In this article, I provide a general overview of the members of the receptorome as well as methods used to screen the receptorome-both in silico and physically. Case histories of receptorome-based discovery efforts are then highlighted and the relevance of this approach to the discovery and validation of molecular targets for drug abuse treatment is emphasized.
Roth
Bryan L
BL
Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH 44106, USA. bryan.roth@case.edu
D015195:Drug Design; D006801:Humans; D008024:Ligands; D011956:Receptors, Cell Surface / Q000378:metabolism*; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000378:metabolism
D008024:Ligands; D011956:Receptors, Cell Surface