title: Macular hole development in fellow eyes of patients with unilateral macular hole.
abstract: OBJECTIVE
  To determine the incidence of developing an idiopathic full-thickness macular hole in fellow eyes that have vitreofoveal attachments and perifoveal vitreous detachment in patients with unilateral idiopathic macular hole.
  
  
  METHODS
  Retrospective cross-sectional observational study.
  
  
  METHODS
  The fellow eyes of 201 patients with full-thickness macular holes were examined by optical coherence tomography (OCT). A subset of 58 fellow eyes with vitreofoveal attachments and perifoveal vitreous detachment was observed during follow-up, and the changes in the vitreofoveal attachment within 24 months from the initial OCT examination were investigated.
  
  
  RESULTS
  In the 58 eyes, the vitreofoveal relationship changed in 27 eyes. Among the 27 eyes, three eyes developed a full-thickness macular hole, and the other 24 eyes developed a posterior vitreous detachment only over the fovea or a complete posterior vitreous detachment without macular hole formation. The vitreofoveal relationship did not change in 31 eyes during the 24-month period.
  
  
  CONCLUSIONS
  From an analysis of the changes in the vitreoretinal relationship identified by OCT, three (11%) of 27 fellow eyes in patients with unilateral idiopathic macular hole developed a full-thickness macular hole.
authors.affiliation: Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Niwa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Terasaki
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Ito
authors.forename: Yozo
authors.initials: Y
authors.lastname: Miyake
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D005128:Eye Diseases / Q000175:diagnosis*; D005260:Female; D005584:Fovea Centralis / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012167:Retinal Perforations / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014822:Vitreous Body / Q000473:pathology*; D020255:Vitreous Detachment / Q000175:diagnosis*