title: Impact of disease severity on quality of life in adults with asthma.
abstract: Health-related quality of life is increasingly used as an outcome measure in asthma. The aim of this study was to define the relationship between asthma symptoms, lung function and health related quality of life in a community based sample of people with asthma ranging from no recent asthma to severe persistent asthma. We recruited subjects at the age of 42 years from a well-described community cohort, the Melbourne Epidemiological Study of Childhood Asthma, to define this association. 161 subjects completed a respiratory symptom survey, the Asthma Quality of Life Questionnaire and had lung function testing. According to the previous surveys and when applicable in agreement with GINA, subjects were classified into 4 groups: no recent asthma, sporadic asthma, intermittent asthma and persistent asthma, with the persistent asthma group further categorised by wheezing frequency and lung function. 55 had no recent asthma, 31 had sporadic asthma, 39 had intermittent asthma and 36 had persistent asthma. There was clear evidence of lower total scores with increased asthma severity, with median scores of 6.8 for the sporadic asthma group, 6.4 for the intermittent and 5.5 for the persistent asthma group compared to 6.9 in those with no recent asthma. All domain scores within the intermittent and persistent asthma groups were lower than scores for the no recent asthma group (p < 0.01). Those with persistent asthma and low FEV1% had the lowest quality of life scores (4.6). Analysis of this population cohort highlights that health related quality of life in patients with asthma strongly depends on symptom frequency and lung function and underlines the necessity of adequate treatment.
authors.affiliation: Department of Respiratory Medicine, Royal Children's Hospital, Parkville, Australia.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Horak
authors.forename: Susan M
authors.initials: SM
authors.lastname: Sawyer
authors.forename: Mary
authors.initials: M
authors.lastname: Roberts
authors.forename: Anna
authors.initials: A
authors.lastname: Lanigan
authors.forename: John B
authors.initials: JB
authors.lastname: Carlin
authors.forename: Anthony
authors.initials: A
authors.lastname: Olinsky
authors.forename: Colin F
authors.initials: CF
authors.lastname: Robertson
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology*; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D017063:Outcome Assessment, Health Care / Q000379:methods*; D011788:Quality of Life; D020127:Recovery of Function; D012129:Respiratory Function Tests / Q000706:statistics & numerical data*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D011795:Surveys and Questionnaires