title: [The catalytic rate constant. Effect of acetone on acidic hydrolysis of ester cyclohexyl acidacetylomethyl (AmMC)].
abstract: The catalytic rate constants k(HCl) were established for hydrolysis of beta-lactam moiety in AmMC using equation k(obs) = k(H2O) + k(HCl)[HCl]. The estimate the effect of aceton the relation log k(HCl) = log kD + k Z(mu)/D was applied. The rate constant increases with the decrease of dielectric constant of the solvent.
authors.affiliation: Zakład Chemii Farmaceutycznej, Akademia Medyczna, ul. Grunwaldzka 6, 60-780 Poznań.
authors.forename: A
authors.initials: A
authors.lastname: Barańczyk
authors.forename: M
authors.initials: M
authors.lastname: Zajac
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000096:Acetone / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002384:Catalysis; D003510:Cyclohexanes; D004951:Esterification; D006868:Hydrolysis / Q000187:drug effects; D047090:beta-Lactams / Q000737:chemistry*
chemical_list: C112420:(1-(aminomethyl)-3-methylcyclohexyl)acetic acid; D000085:Acetates; D000900:Anti-Bacterial Agents; D003510:Cyclohexanes; D047090:beta-Lactams; D000096:Acetone