A facile synthesis of the GalNAcbeta1-->4Gal target sequence of respiratory pathogens.
The carbohydrate sequence, GalNAcbeta1-->4Gal, is the target for the adhesion of several respiratory pathogens. The sequence was prepared in an optimized synthesis in forms that allow conjugation to scaffolds or surfaces.
Autar
Reshma
R
Utrecht Institute for Pharmaceutical Sciences, Department of Medicinal Chemistry, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Liskamp
Rob M J
RM
Pieters
Roland J
RJ
D000116:Acetylgalactosamine / Q000737:chemistry*; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000138:chemical synthesis* / Q000378:metabolism; D005690:Galactose / Q000737:chemistry*; D006193:Haemophilus influenzae / Q000378:metabolism; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D012137:Respiratory System / Q000382:microbiology; D013211:Staphylococcus aureus / Q000378:metabolism
D004187:Disaccharides; C033878:N-acetylgalactosaminyl-(1-4)-galactose; D000116:Acetylgalactosamine; D005690:Galactose