title: Matrix metalloproteinases in cerebrovascular diseases.
abstract: Matrix metalloproteinases are important factors for tissue remodelling and are activated during several physiological and pathological conditions, including cerebrovascular diseases. We give an overview of the structure, production and physiological effects of these widely distributed proteases and describe the genetic background and regulation pathways. In particular, we discuss the role of matrix metalloproteinases in vascular remodelling concerning ischaemic stroke, brain haemorrhage, vascular dementia, carotid artery plaques and cerebral aneurysms.
authors.affiliation: Department of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany. fatar@neuro.ma.uni-heidelberg.de
authors.forename: Marc
authors.initials: M
authors.lastname: Fatar
authors.forename: Mark
authors.initials: M
authors.lastname: Stroick
authors.forename: Martin
authors.initials: M
authors.lastname: Griebe
authors.forename: Michael
authors.initials: M
authors.lastname: Hennerici
mesh_terms: D002561:Cerebrovascular Disorders / Q000201:enzymology / Q000209:etiology* / Q000235:genetics; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000502:physiology*
chemical_list: D020782:Matrix Metalloproteinases