title: Drug-induced hypersensitivity syndrome due to carbamazepine associated with reactivation of human herpesvirus 7.
abstract: We report a 63-year-old Japanese man with epilepsy who developed skin eruptions, liver dysfunction, high fever, leukocytosis and atypical lymphocytosis 4 weeks after he had started taking carbamazepine. Titers of human herpesvirus 7 (HHV-7)-specific IgG antibodies were significantly increased and HHV-7 DNA was detected in his serum by polymerase chain reaction. These findings suggested that reactivation of HHV-7 could contribute to the development of drug-induced hypersensitivity syndrome.
authors.affiliation: Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan. hhara@med.nihon-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hara
authors.forename: Maiko
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Ai
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tochigi
authors.forename: Akie
authors.initials: A
authors.lastname: Matsunaga
authors.forename: Hidenao
authors.initials: H
authors.lastname: Shimizu
authors.forename: Junko
authors.initials: J
authors.lastname: Goshima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy; D005500:Follow-Up Studies; D016199:Herpesvirus 7, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D016133:Polymerase Chain Reaction / Q000379:methods; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D018570:Risk Assessment; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000188:drug therapy; D012720:Severity of Illness Index
chemical_list: D004279:DNA, Viral; D002220:Carbamazepine; D011239:Prednisolone