A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.
Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.
Hunt
Mary C
MC
Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry C1-74, Karolinska University Hospital at Huddinge, Stockholm, Sweden. mary.hunt@labmed.ki.se
Yamada
Junji
J
Maltais
Lois J
LJ
Wright
Mathew W
MW
Podesta
Ernesto J
EJ
Alexson
Stefan E H
SE
D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D051379:Mice; D005810:Multigene Family; D010170:Palmitoyl-CoA Hydrolase / Q000235:genetics; D051381:Rats; D009626:Terminology as Topic
D010170:Palmitoyl-CoA Hydrolase