Quinine for the treatment of uncomplicated Plasmodium falciparum malaria in eastern Sudan.
An observational clinical trial was conducted in New Halfa, eastern Sudan, in November and December 2003. Sixty-two patients with uncomplicated Plasmodium falciparum malaria were treated with oral quinine (10 mg/kg thrice daily for 7 d); 47 (76%) of these patients were followed-up to day 28, and 5 (10.6%) of them appeared to have late treatment failures. The parasitological failures were early R1 in two (4.3%) patients and late R1 in three (6.4%) patients. The reappearance of parasites in three of these five patients were true recrudescences rather than a re-infection, based on genetic evidence. The present results and those of earlier investigations indicate that the response to quinine in this area may be faltering.
Adam
Ishag
I
New Halfa Teaching Hospital, Sudan. ishagadam@hotmail.com
Salih
Isam
I
Elbashir
Mustafa Idris
MI
D000284:Administration, Oral; D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011803:Quinine / Q000627:therapeutic use*; D013397:Sudan; D016896:Treatment Outcome
D000962:Antimalarials; D011803:Quinine