title: DNA pooling analysis of ADHD and genes regulating vesicle release of neurotransmitters.
abstract: ADHD is one of the most prevalent, and heritable behavioural disorders in childhood. Genetic associations have been reported with polymorphic variants within or near to dopamine pathway genes. Recently snap-25 has also shown association with ADHD in several datasets. We therefore investigated other genes that produce proteins that interact with SNAP-25 in the mechanism of vesicular release of neurotransmitters at the synapse. A total of 106 SNPs were screened for minor allele frequency greater than 5% and 61 SNPs selected for analysis in DNA pools made up from an ADHD clinical sample of DSM-IV combined type probands (n = 180) and a control sample of 90 males and 90 females. Initial screening identified several SNPs that showed allele frequency differences of 5% or more. One SNP in the synaptophysin gene showed suggestive evidence of association following case-control and TDT analysis and warrants further investigation.
authors.affiliation: MRC Social, Genetic Developmental Psychiatry Centre, Institute of Psychiatry, United Kingdom.
authors.forename: K J
authors.initials: KJ
authors.lastname: Brookes
authors.forename: J
authors.initials: J
authors.lastname: Knight
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: P
authors.initials: P
authors.lastname: Asherson
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000378:metabolism*; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D005788:Gene Pool; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D013569:Synapses / Q000378:metabolism*
chemical_list: D005819:Genetic Markers; D018377:Neurotransmitter Agents; D004247:DNA