Maternal and female fetal virilization caused by pregnancy luteomas.
OBJECTIVE
To present the maternal and female fetal virilization caused by excessive androgen secretion of pregnancy luteomas.


METHODS
Case report.


METHODS
University-based teaching hospital.


METHODS
A nulligravida woman suffering from bilateral hydronephrosis and recurrent acute pyelonephritis caused by bilateral solid ovarian tumors presented virilization during the third trimester. Without prompt surgical intervention, the maternal hyperandrogenemia returned to a normal level and regression of bilateral ovarian tumors occurred spontaneously after a female fetus with clitoral hypertrophy and temporal hyperandrogenemia was delivered. In spite of lacking histology, the clinical course is compared to that of pregnancy luteomas.


METHODS
Noninvasive imaging assessment.


METHODS
Maternal and female fetal virilization.


RESULTS
Regression of androgen-secreting pregnancy luteomas and hyperandrogenism during the puerperium but apparent female fetal clitoral hypertrophy.


CONCLUSIONS
The maternal and female fetal virilization was caused by exaggerating androgen secretion of bilateral ovarian solid tumors. Spontaneous regression of ovarian tumors and hyperandrogenemia during the puerperium is the natural course of pregnancy luteomas, not true neoplasms.
Wang
Yu-Chi
YC
Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei, Taiwan, ROC.
Su
Her-Young
HY
Liu
Jah-Yao
JY
Chang
Fung-Wei
FW
Chen
Chi-Huang
CH
D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D018311:Luteoma / Q000150:complications / Q000175:diagnosis*; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014770:Virilism / Q000175:diagnosis* / Q000209:etiology