title: [Antisecretory therapy as a component of hemostasis in acute gastroduodenal ulcer bleedings].
abstract: Results of antisecretory therapy (pyrenzepin, H(2)-blockers, inhibitors of proton pump, octreotid) in 962 patients with acute gastroduodenal ulcer bleedings (AGDUB) were analyzed over 14-years period. Antisecretory treatment in AGDUB has principally different goals and potential depending on risk of bleeding's recurrence and morphological changes in tissue of gastroduodenal ulcer. Antisecretory therapy is the main treatment in high risk of AGDUB recurrence or before urgent surgery. Intravenous infusion of omeprazol has demonstrated the highest clinical efficacy due to maximal inhibition of gastric secretion and absence of negative influences on oxygen regimen in tissue of ulcer.
authors.forename: V K
authors.initials: VK
authors.lastname: Gostishchev
authors.forename: M A
authors.initials: MA
authors.lastname: Evseev
mesh_terms: D000208:Acute Disease; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D015738:Famotidine / Q000627:therapeutic use; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D015282:Octreotide / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000150:complications* / Q000188:drug therapy*; D010438:Peptic Ulcer Hemorrhage / Q000150:complications* / Q000188:drug therapy*; D010890:Pirenzepine / Q000627:therapeutic use; D054328:Proton Pump Inhibitors
chemical_list: D000897:Anti-Ulcer Agents; D005765:Gastrointestinal Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D010890:Pirenzepine; D015738:Famotidine; D009853:Omeprazole; D015282:Octreotide