title: Vestibular symptoms and signs are correlated with abnormal neurogenic vestibular evoked potentials in patients with multiple sclerosis.
abstract: OBJECTIVE
  Symptoms of disequilibrium in multiple sclerosis (MS) are common. Neurogenic vestibular evoked potentials (NVsEPs) are saccular responses to tone-pip acoustic stimuli and are recordable from the parietal areas ipsilaterally to the stimulated ear. We wished to determine possible correlations of abnormal findings in NVsEP with clinical neurological findings related to the vestibular system, and demyelination seen on MRI.
  
  
  METHODS
  NVsEPs were performed by delivering a 1 kHz tone-pip stimulus monoaurally with contralateral masking noise via headphones. Brainstem auditory evoked potentials were performed in the standard manner.
  
  
  RESULTS
  Thirty-three patients had either been diagnosed with MS or had possible MS. There is statistical evidence that the presence of symptoms is likely to give an abnormal NVsEP, but no correlation exists between the presence or absence of vestibular symptoms and signs and an abnormal BAEP. No correlation was found between the presence of brainstem lesions on MRI and an abnormal NVsEP. Correlation exists between abnormal NVsEP and the level of disability using Expanded Disability Status Scale scores.
  
  
  CONCLUSIONS
  We have found that with increasing involvement of abnormal NVsEPs, there is a significant correlation with symptoms and signs that can be referred to the vestibular system.
authors.affiliation: Department of Clinical Neurophysiology, The Cyprus Institute of Neurology & Genetics, 6 International Airport Avenue, PO Box 23462, Nicosia 1683, Cyprus. neurophy@cing.ac.cy
authors.forename: E S
authors.initials: ES
authors.lastname: Papathanasiou
authors.forename: C
authors.initials: C
authors.lastname: Piperidou
authors.forename: M
authors.initials: M
authors.lastname: Pantzaris
authors.forename: I
authors.initials: I
authors.lastname: Iliopoulos
authors.forename: M
authors.initials: M
authors.lastname: Petsa
authors.forename: T
authors.initials: T
authors.lastname: Kyriakides
authors.forename: K A
authors.initials: KA
authors.lastname: Kleopa
authors.forename: S S
authors.initials: SS
authors.lastname: Papacostas
mesh_terms: D000293:Adolescent; D000328:Adult; D003711:Demyelinating Diseases; D004185:Disability Evaluation; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D015837:Vestibular Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*