Neutrophil-derived serine proteases in immune complex-mediated diseases.
Neutrophil-derived serine proteases play an important role in fighting infections. However, emerging data suggest that these proteases also regulate noninfectious inflammatory responses. Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases.
Raptis
Sofia Z
SZ
Washington University School of Medicine, St. Louis, MO 63110, USA.
Pham
Christine T N
CT
D000818:Animals; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D003594:Cytoplasmic Granules / Q000201:enzymology; D006801:Humans; D007105:Immune Complex Diseases / Q000201:enzymology* / Q000276:immunology*; D007239:Infections / Q000201:enzymology / Q000276:immunology; D007249:Inflammation / Q000201:enzymology / Q000276:immunology; D051379:Mice; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology*; D012697:Serine Endopeptidases / Q000276:immunology*
D012697:Serine Endopeptidases