title: Predictive value of C-reactive protein in patients with unstable angina pectoris undergoing coronary artery stent implantation.
abstract: In-stent restenosis is a major problem following coronary stent implantation, and inflammation plays an active role. We evaluated the effectiveness of the inflammatory marker C-reactive protein (CRP) as a predictor of in-stent restenosis after successful stent implantation, in 86 patients with unstable angina pectoris. Plasma CRP was measured in all patients before the procedure, and at 48 - 72 h and 1, 2 and 3 months post-procedure. An angiographic loss of 50% at follow-up was accepted as in-stent restenosis. We found negative and positive predictive values of the pre-procedural plasma CRP for determining 6-month in-stent restenosis of 34% and 61%, respectively. We also found a strong correlation between the 3-month post-procedural CRP value and 6-month in-stent restenosis; the negative and positive predictive values being 8% and 76%, respectively. In conclusion, we showed that a plasma CRP value > 3 mg/l in the third month after coronary stent implantation was a strong predictor of angiographic in-stent restenosis.
authors.affiliation: Department of Cardiology, Firat University School of Medicine, Elaziğ, Turkey. ilgink@yahoo.com
authors.forename: I
authors.initials: I
authors.lastname: Karaca
authors.forename: K
authors.initials: K
authors.lastname: Aydin
authors.forename: M
authors.initials: M
authors.lastname: Yavuzkir
authors.forename: E
authors.initials: E
authors.lastname: Ilkay
authors.forename: M
authors.initials: M
authors.lastname: Akbulut
authors.forename: A
authors.initials: A
authors.lastname: Isik
authors.forename: N
authors.initials: N
authors.lastname: Arslan
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000096:biosynthesis* / Q000378:metabolism; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000175:diagnosis*; D023921:Coronary Stenosis; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D015607:Stents; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein