Interleukin-6: An osteotropic factor influencing bone formation?
Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted.
Franchimont
Nathalie
N
Department of Rheumatology, Center for Cellular and Molecular Therapy, University of Liège, CHU Sart-Tilman, Belgium. nfranchimont@ulg.ac.be
Wertz
Sylvie
S
Malaise
Michel
M
D000818:Animals; D017209:Apoptosis; D001862:Bone Resorption / Q000503:physiopathology; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D020738:Leptin / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology / Q000473:pathology / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D019947:Receptors, Interleukin-6 / Q000502:physiology; D015398:Signal Transduction
D015850:Interleukin-6; D020738:Leptin; D019947:Receptors, Interleukin-6