Unravelling hepatitis C virus replication from genome to function.
Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this pathogen has met with roadblocks that impeded progress. Its replication was restricted to humans or experimentally infected chimpanzees, and efficient growth of the virus in cell culture failed until very recently. Nevertheless hard-fought progress has been made and the first wave of antiviral drugs is entering clinical trials.
Lindenbach
Brett D
BD
Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Rice
Charles M
CM
D000818:Animals; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D016174:Hepacivirus / Q000737:chemistry / Q000235:genetics* / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
D012367:RNA, Viral; D014764:Viral Proteins