title: Duration of postviral airway hyperresponsiveness in children with asthma: effect of atopy.
abstract: BACKGROUND
  Respiratory viruses induce asthma exacerbations and airway hyperresponsiveness (AHR). Atopy is an important risk factor for asthma persistence.
  
  
  OBJECTIVE
  We sought to evaluate whether atopy is a risk factor for prolonged AHR after upper respiratory tract infections (URIs).
  
  
  METHODS
  Twenty-five children (13 atopic and 12 nonatopic children) with intermittent virus-induced asthma were studied. Clinical evaluation, skin prick tests, methacholine bronchoprovocation, questionnaires, and a nasal wash specimen were obtained at baseline. For 9 months, subjects completed diary cards with respiratory symptoms. During their first reported cold, a nasal wash specimen was obtained. Methacholine provocation was performed 10 days and 5, 7, 9, and 11 weeks later. In case a new cold developed, the provocation schedule was followed from the beginning.
  
  
  RESULTS
  Viruses were detected in 17 (68%) of 25 patients during their first cold, with rhinovirus being most commonly identified (82%). AHR increased significantly 10 days after the URI, equally in both groups (P = .67), and remained so up to the fifth week. Duration of AHR in subjects experiencing a single URI ranged from 5 to 11 weeks, without a significant difference between groups. In the duration of the study, atopic children experienced more colds and asthma exacerbations than nonatopic children. Thus for duration of AHR, significant prolongation was noted in the atopic group when assessed cumulatively.
  
  
  CONCLUSIONS
  In asthmatic children the duration of AHR after a single natural cold is 5 to 11 weeks. However, an increased rate of symptomatic cold and asthma episodes in atopic children is associated with considerable cumulative prolongation of AHR, which might help explain the role of atopy as a risk factor for asthma persistence.
authors.affiliation: Allergy Unit, 2nd Pediatric Clinic, University of Athens.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Xepapadaki
authors.forename: Nikolaos G
authors.initials: NG
authors.lastname: Papadopoulos
authors.forename: Apostolos
authors.initials: A
authors.lastname: Bossios
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Manoussakis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Manousakas
authors.forename: Photini
authors.initials: P
authors.lastname: Saxoni-Papageorgiou
mesh_terms: D001249:Asthma / Q000150:complications*; D016535:Bronchial Hyperreactivity / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D003139:Common Cold / Q000150:complications; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D008297:Male; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000150:complications*; D013997:Time Factors; D014777:Virus Diseases / Q000150:complications* / Q000175:diagnosis; D014780:Viruses / Q000302:isolation & purification