title: Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats.
abstract: Selective Serotonin Reuptake Inhibitors (SSRIs) are designed to treat adults, but are increasingly prescribed for adolescents. SSRIs might cause permanent changes in serotonin-related behavior in adolescents, since their serotonergic system is still developing. Male Wistar rats were treated with paroxetine (15 mg/kg p.o.) or fluvoxamine (30 mg/kg p.o.) throughout adolescence. After a washout period their behavior in the elevated plus-maze, prepulse inhibition test, Forced swimming test and elevated T-maze were studied. In addition, the effects of the 5-HT(1A) receptor agonist 8-OH-DPAT on sexual behavior and lower lip retraction were measured. Paroxetine mildly inhibited weight gain during treatment. Both SSRIs caused a reduction in ejaculation frequency and in time spent on the open arm of the elevated plus-maze in adult rats. Fluvoxamine slightly increased avoidance latency in the elevated T-maze compared to paroxetine. No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior.
authors.affiliation: Department of Anatomy, Radboud University Nijmegen Medical Centre, (Intern Mail Nr. 230) Postbus 9101 6500 HB, Nijmegen, The Netherlands. t.dejong@pnf.umcn.nl
authors.forename: Trynke R
authors.initials: TR
authors.lastname: de Jong
authors.forename: Liselore J A E
authors.initials: LJ
authors.lastname: Snaphaan
authors.forename: Tommy
authors.initials: T
authors.lastname: Pattij
authors.forename: Jan G
authors.initials: JG
authors.lastname: Veening
authors.forename: Marcel D
authors.initials: MD
authors.lastname: Waldinger
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Cools
authors.forename: Berend
authors.initials: B
authors.lastname: Olivier
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000161:Acoustic Stimulation / Q000379:methods; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004307:Dose-Response Relationship, Radiation; D004347:Drug Interactions; D016666:Fluvoxamine / Q000494:pharmacology*; D007266:Inhibition, Psychological; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D017374:Paroxetine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013216:Reflex, Startle / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013550:Swimming
chemical_list: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D016666:Fluvoxamine; D017374:Paroxetine; D012701:Serotonin; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors