[Expression of foot and mouth disease virus antigens in transgenic plants].
Owing to its geographical distribution and its highly contagious character, the foot and mouth disease (FMD) virus is responsible for one of the most dreaded of all livestock diseases. The currently-used vaccine is polyvalent and is based on an inactivated virus. Current research on FMD vaccines focuses on the creation of vaccines that are easier and cheaper to produce, and that avoid manipulation of large quantities of virus. The use of transgenic plants to express relevant antigens has been evaluated for the purpose of vaccine production. The authors' working group has taken the FMD virus as a model to evaluate the feasibility of using transgenic plants to express viral antigens and to develop experimental vaccines. The purpose of this paper is to set forth the working group's results in the expression of FMD antigens in transgenic plants.
Dus Santos
M J
MJ
Instituto de Virología, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, INTA-Castelar, C.C 77, Castelar (1712), Buenos Aires, Argentina.
Wigdorovitz
A
A
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D007114:Immunization / Q000662:veterinary; D030821:Plants, Genetically Modified; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D014765:Viral Vaccines / Q000276:immunology*
D000956:Antigens, Viral; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D014765:Viral Vaccines