Copper(II) acetate promoted intramolecular diamination of unactivated olefins.
A concise method for the synthesis of cyclic sulfamides and vicinal diamines is presented. This method is enabled by Cu(OAc)2 and demonstrates a new transformation for this metal. Both five- and six-membered vicinal diamine-containing heterocycles have been synthesized in good to excellent yields, and substrate-based asymmetric induction has been achieved. This is the first reported example of intramolecular diamination of olefins.
Zabawa
Thomas P
TP
Department of Chemistry, 618 Natural Sciences Complex, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Kasi
Dhanalakshmi
D
Chemler
Sherry R
SR