title: 2B4/CD48-mediated regulation of lymphocyte activation and function.
abstract: 2B4 (CD244) is a member of the CD2 subset of the Ig superfamily. This molecule is expressed on innate immune cells, including NK cells, and on subsets of T cells. The 2B4 molecule interacts with CD48, which is widely expressed on hemopoietic cells. Although earlier reports demonstrated a role for 2B4 as an activating receptor in both mice and humans, recent studies of 2B4-deficient mice have suggested that 2B4 functions predominantly as an inhibitory receptor in mice. In addition, 2B4 may also act as a costimulatory ligand for cells expressing CD48. Thus, the 2B4 molecule is more multifunctional than previously understood. In this study, we delineate the current view of 2B4-CD48 interactions among lymphocytes and other cells.
authors.affiliation: Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. erika@liai.org
authors.forename: Erika
authors.initials: E
authors.lastname: Assarsson
authors.forename: Taku
authors.initials: T
authors.lastname: Kambayashi
authors.forename: Catrine M
authors.initials: CM
authors.lastname: Persson
authors.forename: Benedict J
authors.initials: BJ
authors.lastname: Chambers
authors.forename: Hans-Gustaf
authors.initials: HG
authors.lastname: Ljunggren
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D000071178:CD48 Antigen; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D000071176:Signaling Lymphocytic Activation Molecule Family; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D000071178:CD48 Antigen; C000604065:CD48 protein, human; C490007:Cd244a protein, mouse; C000604066:Cd48 protein, mouse; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family