Germ cells: sex and repression in mice.
The mouse Blimp1 gene encodes a transcriptional repressor that is essential for B-cell development. Recent studies have shown that the Blimp1 protein also plays a critical role in the specification of mouse primordial germ cells.
Raz
Erez
E
Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11 37070, Goettingen,Germany.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005854:Germ Cells / Q000166:cytology*; D051379:Mice; D008954:Models, Biological; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000378:metabolism* / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology
C513258:Prdm1 protein, mouse; D012097:Repressor Proteins; D014157:Transcription Factors; D000074462:Positive Regulatory Domain I-Binding Factor 1