title: Philadelphia-chromosome positive thrombocythemia in a child.
abstract: Philadelphia-chromosome positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood has been described in adults. It is rare in children. We present a case of Philadelphia positive thrombocythemia in a child who was managed with a combination of imatinib and hydroxyurea. Although a reduction in the BCR-ABL transcript was documented, the thrombocytosis was refractory to imatinib alone and required the addition of hydroxyurea.
authors.affiliation: Department of Hematology, AIIMS, Delhi, India.
authors.forename: Pravas
authors.initials: P
authors.lastname: Mishra
authors.forename: M
authors.initials: M
authors.lastname: Mahapatra
authors.forename: Rajat
authors.initials: R
authors.lastname: Kumar
authors.forename: Ashish
authors.initials: A
authors.lastname: Dixit
authors.forename: Tathagat
authors.initials: T
authors.lastname: Chatterjee
authors.forename: Seema
authors.initials: S
authors.lastname: Tyagi
authors.forename: D R
authors.initials: DR
authors.lastname: Choudhry
authors.forename: S
authors.initials: S
authors.lastname: Sazawal
authors.forename: V P
authors.initials: VP
authors.lastname: Choudhry
mesh_terms: D001549:Benzamides; D001853:Bone Marrow / Q000648:ultrastructure; D002648:Child; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000627:therapeutic use; D000068877:Imatinib Mesylate; D010677:Philadelphia Chromosome; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use; D013922:Thrombocytosis / Q000188:drug therapy / Q000235:genetics*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D006918:Hydroxyurea