Will admixture mapping work to find disease genes?
Admixture mapping is the first experimentally practical method for carrying out a whole-genome association scan, and is thus a promising method for detecting risk factors for common disease. The goal of the community should now be to aggressively test whether the method is useful in practice for localizing disease genes, by carrying out at least three high-powered studies. We also propose a stringent criteria we believe the community should adopt before declaring a statistically significant admixture association to disease.
Reich
David
D
Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.usa
Patterson
Nick
N
D002874:Chromosome Mapping / Q000379:methods* / Q000592:standards; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D006801:Humans; D012307:Risk Factors