title: [Cardiovascular effects of human atrial natriuretic peptide during pediatric renal transplantation].
abstract: BACKGROUND
  We evaluated the cardiovascular effects of human atrial natriuretic peptide (hANP) in the pediatric recipients undergoing renal transplantation.
  
  
  METHODS
  Anesthesia was maintained by inhalation of nitrous-oxide and isoflurane in oxygen. Intravenous infusion of hANP at a rate of 0.05 microg x kg(-1) x min(-1) was started on the anastomosis of the renal artery after the fresh frozen plasma had been loaded to achieve PCWP above 17 mmHg. We examined cardiovascular changes by using a pulmonary artery catheter and transesophageal echocardiography. The measurements were done before and after 15 minutes of hANP infusion.
  
  
  RESULTS
  An increase in CI and a reduction in PCWP were significant.
  
  
  CONCLUSIONS
  The low-dose infusion of hANP was useful in pediatric recipients undergoing renal transplantation for the optimal anesthetic care in view of the improvement of cardiovascular functions.
authors.affiliation: First Department of Anesthesiology, Toho University School of Medicine, Tokyo 143-8541.
authors.forename: Takashi
authors.initials: T
authors.lastname: Terada
authors.forename: Yohachiro
authors.initials: Y
authors.lastname: Hirano
authors.forename: Reika
authors.initials: R
authors.lastname: Akutsu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Toyoda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Maki
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Ochiai
mesh_terms: D000293:Adolescent; D000769:Anesthesia, Inhalation; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D002648:Child; D002675:Child, Preschool; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D016030:Kidney Transplantation; D008297:Male; D011669:Pulmonary Wedge Pressure
chemical_list: D009320:Atrial Natriuretic Factor