title: Evaluation of efficacy of an automated single-voxel proton MRS algorithm on a 3T system.
abstract: OBJECTIVE
  To evaluate the efficacy of a fully automatic, single-voxel, proton MR spectroscopy algorithm on a 3.0T MR system.
  
  
  METHODS
  The PROBE/SVQ algorithm (GE Medical Systems) was evaluated on a General Electric (GE) Signa LX-3T system. Ten normal volunteers (female, 21.1+/-2.0 years old) participated in the study. Nine representative regions of interest were examined, namely, right and left frontal white matter; right and left parietal white matter; right and left basal ganglia; right and left dentate nucleus; and pons.
  
  
  RESULTS
  The mean coefficients of variation in all regions for the N-acetyl-aspartate to creatine ratio (NAA/Cr), choline to creatine ratio (Cho/Cr), and choline to N-acetyl-aspartate ratio (Cho/NAA) were 10.2+/-2.4%, 11.4+/-3.2% and 12.6+/-1.4%, respectively.
  
  
  CONCLUSIONS
  A fully automated spectroscopic examination under clinical setting utilizing the PROBE/SVQ algorithm appears to be a reliable method, extending the window of routine clinical assessment of brain metabolism.
authors.affiliation: Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, University of Niigata, 2-746 Asahimachi-dohri, Niigata-shi, Niigata 951-8518, Japan. mook@clg.niigata-u.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohkubo
authors.forename: Teruo
authors.initials: T
authors.lastname: Kimura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Matsuzawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Matsuda
authors.forename: Ingrid L
authors.initials: IL
authors.lastname: Kwee
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakada
mesh_terms: D000328:Adult; D000465:Algorithms; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001331:Automation; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline