title: Poly(ADP-ribose) polymerase activation by reactive nitrogen species--relevance for the pathogenesis of inflammation.
abstract: Oxidative and nitrosative stress triggers DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) polymerase (PARP). Nitrogen-derived reactive oxidant species capable of involving DNA single strand breakage and PARP activation include peroxynitrite (the reaction product of nitric oxide and superoxide), but not nitric oxide per se. Activation of PARP may dramatically lower the intracellular concentration of its substrate, nicotinamide adenine dinucleotide, thus slowing the rate of glycolysis, electron transport, and subsequently ATP formation. This process can result in cell dysfunction and cell death. Here we review the role of reactive nitrogen species in the process of PARP activation, followed by the effect of pharmacological inhibition or genetic inactivation of PARP on the course of various forms of inflammation.
authors.affiliation: Department of Human Physiology and Clinical Experimental Research, Semmelweis University Medical School, Budapest, Hungary. szabocsaba@aol.com
authors.forename: Csaba
authors.initials: C
authors.lastname: Szabó
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D007249:Inflammation / Q000201:enzymology / Q000209:etiology*; D051379:Mice; D008954:Models, Biological; D030421:Peroxynitrous Acid / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000096:biosynthesis*; D026361:Reactive Nitrogen Species / Q000502:physiology*
chemical_list: D026361:Reactive Nitrogen Species; D030421:Peroxynitrous Acid; D011065:Poly(ADP-ribose) Polymerases