Reversal of hepatoma cells resistance to anticancer drugs is correlated to cell proliferation kinetics, telomere length and telomerase activity.
BACKGROUND
Clinical and experimental observations indicate that resistance to anticancer drugs may be spontaneously reversible over time.


METHODS
This work is a mathematical and statistical analysis of the relationship, during a 9-month experiment, between the resistance of repeatedly re-seeded hepatoma cells to methotrexate (MTX) or to cisplatin (cisP) and untreated cell proliferation, telomere length and telomerase activity.


RESULTS
All variables showed complex oscillations, as previously published. In this work, cell proliferation was modelized by the logistic model, and the proliferation rates (a-values) together with their variations (va-values) were calculated.


CONCLUSIONS
Significant correlations were discovered between cell resistance to treatments and a-values, va-values, telomere length and telomerase activities. These results open new insights into the handling of chemotherapy in the treatment of cancers.
Chau
Nguyen Phong
NP
Equipe Biomath-Biostat, Université Paris 7-Denis Diderot, 2 place Jussieu, 75251 Paris, France.
Deschatrette
Jean
J
Wolfrom
Claire
C
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D048708:Cell Growth Processes / Q000502:physiology; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016015:Logistic Models; D008727:Methotrexate / Q000494:pharmacology*; D011237:Predictive Value of Tests; D051381:Rats; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000502:physiology*
D000970:Antineoplastic Agents; D019098:Telomerase; D002945:Cisplatin; D008727:Methotrexate