title: Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography.
abstract: BACKGROUND
  Endoscopic retrograde cholangiopancreatography (ERCP) is the most complex gastrointestinal procedure, which needs patients' cooperation. The aim of this study was to observe the quality and safety of sedation with propofol in patients undergoing therapeutic ERCP.
  
  
  METHODS
  Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups. One group,given intravenously propofol,and the other sedated with routine method,served as the control. Blood pressure,heart rate, oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation, performance, recovery time and amnesia served as variables postoperation.
  
  
  RESULTS
  Blood pressure elevated in four patients in the propofol group, less than in the control group (P < 0.01). Seven patients showed decreased blood pressure after administration of propofol, but none in the control group (P < 0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P < 0.01). The time for performance in the propofol group (P < 0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P < 0.01). The degree of amnesia better in the propofol group than in the control group (P < 0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01).
  
  
  CONCLUSIONS
  Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives.
authors.affiliation: Digestive Department, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. chenwiexing@hotmail.com
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Chen
authors.forename: Hui-Jia
authors.initials: HJ
authors.lastname: Lin
authors.forename: Wei-Fang
authors.initials: WF
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhong
authors.forename: Chao-Hui
authors.initials: CH
authors.lastname: Yu
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Li
authors.forename: Zhu-Ying
authors.initials: ZY
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D000647:Amnesia / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D016022:Case-Control Studies; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010349:Patient Compliance; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D020127:Recovery of Function; D012120:Respiration Disorders / Q000209:etiology; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D010100:Oxygen; D015742:Propofol