title: Effect of volume guarantee combined with assist/control vs synchronized intermittent mandatory ventilation.
abstract: OBJECTIVE
  To compare the effect of combining assist/control with volume-guarantee (AC+VG) vs synchronized intermittent mandatory ventilation with VG (SIMV+VG) on tidal volume (V(T)), peak inspiratory pressure (PIP), mean airway pressure (MAP), respiratory rate, heart rate, oxygen saturation (SpO(2)), and minute volume (MV) in preterm infants.
  
  
  METHODS
  A total of 12 infants were randomized to receive AC+VG, followed by SIMV+VG, or the opposite sequence for four alternating 2-hour periods.
  
  
  RESULTS
  Airway pressure of machine breaths was higher during SIMV. MV and V(Te) were similar, but more variable during synchronized intermittent mandatory ventilation. The V(Te) of unsupported breaths during SIMV was lower than machine breaths of SIMV and AC. There was more tachycardia and tachypnea with a lower and more variable SpO(2) during SIMV.
  
  
  CONCLUSIONS
  SIMV+VG is associated with higher work of breathing indicated by tachycardia, tachypnea and lower SpO(2) compared to AC+VG. VG appears to be more effective when combined with AC than with SIMV.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Georgetown University Children's Medical Center, Washington, DC 20007, USA.
authors.forename: Kabir
authors.initials: K
authors.lastname: Abubakar
authors.forename: Martin
authors.initials: M
authors.lastname: Keszler
mesh_terms: D045422:Continuous Positive Airway Pressure; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007385:Intermittent Positive-Pressure Ventilation; D012121:Respiration, Artificial / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012143:Respiratory Physiological Phenomena; D013990:Tidal Volume; D014939:Work of Breathing