Bioavailability of indomethacin in liposomes.
The research concerned the influence of the liposomally-entrapped indomethacin on its absorption after intragastric administration to rats. It was found that the indomethacin entrapped in liposomes has a favorable influence on the bioavailability in comparison to sole indomethacin suspension.
Stozek
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Department of Pharmaceutical Technology and Biopharmaceutics, School of Medicine, 16 Krupnicza Str., 31-123 Kraków, Poland.
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D007213:Indomethacin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D008081:Liposomes; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008081:Liposomes; D007213:Indomethacin