title: The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis.
abstract: The pathogenesis of neonatal necrotizing enterocolitis remains poorly understood. Recent evidence suggests that PAF (platelet activating factor) and human toll-like receptors (TLRs) contribute to the pro-inflammatory response that is characteristic of NEC pathology. Understanding the regulation of these molecular interactions may provide new approaches for prevention or treatment of this dreaded condition.
authors.affiliation: Department of Pediatrics, Evanston Northwestern Healthcare and The Evanston Northwestern Healthcare Research Institute, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201, USA. mca113@northwestern.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Caplan
authors.forename: Dyan
authors.initials: D
authors.lastname: Simon
authors.forename: Tamas
authors.initials: T
authors.lastname: Jilling
mesh_terms: D001419:Bacteria / Q000276:immunology; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D020345:Enterocolitis, Necrotizing / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D010972:Platelet Activating Factor / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D016207:Cytokines; D010972:Platelet Activating Factor; D051193:Toll-Like Receptors