[Decrease of mutagenic action of cyclophosphamide by buckwheat melanin preparation].
Melanins are polyphenolic pigments of plants, animals and microbes with antioxidant and antiradiation activity. Water-soluble melanin from buckwheat is experienced as antimutagenic means (0.01-10 mg/kg per os) for cyclophosphamide (20 mg/kg i.p.) in the 3 series of experiments. The frequency of chromosome aberrations in the cells of mice bone marrow after mutagene is reduced 2-6 times once under influence of melanin.
Baraboĭ
V A
VA
Durnev
A D
AD
Oreshchenko
A V
AV
Alekseeva
T N
TN
Ogarkov
V N
VN
Samusenok
L V
LV
Pestunovich
V A
VA
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity*; D019612:Fagopyrum / Q000737:chemistry*; D008297:Male; D008543:Melanins / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000633:toxicity*
D016587:Antimutagenic Agents; D008543:Melanins; D009153:Mutagens; D003520:Cyclophosphamide