Stroke research in the modern era: images versus dogmas.
Recovery of function following ischaemic stroke is a fascinating clinical observation. It comprises several modes, e.g. spectacular recovery in a matter of hours or days and gradual recovery over months or even years. That a non-functioning neural system can regain its function, even partially so, is challenging because of the obvious therapeutic implications. Until the mid-70s, however, dogmas largely prevailed which underpinned the then nihilistic approach to stroke patients. Proving these dogmas wrong has been a major achievement of modern stroke research. Thanks particularly to physiological imaging, key observations from the basic neurosciences have translated into the clinical realm in ways immediately understandable to the clinician, allowing the emergence of pathophysiology-based management.
Baron
Jean-Claude
JC
Department of Neurology and Stroke Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. jcb54@cam.ac.uk
D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D011859:Radiography; D011877:Radionuclide Imaging; D020127:Recovery of Function / Q000502:physiology; D020521:Stroke / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*