title: Electroanalytical study of the antidepressant sertraline.
abstract: A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 x 10(-6) and 1.20 x 10(-6) mol L(-1). Limits of detection and quantification were found to be 1.5 x 10(-7) and 5.0 x 10 (-7) mol L(-1), respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.
authors.affiliation: REQUIMTE, Instituto Superior de Engenharia do Porto, Portugal.
authors.forename: Henri P A
authors.initials: HP
authors.lastname: Nouws
authors.forename: Cristina
authors.initials: C
authors.lastname: Delerue-Matos
authors.forename: Aquiles A
authors.initials: AA
authors.lastname: Barros
authors.forename: José A
authors.initials: JA
authors.lastname: Rodrigues
mesh_terms: D004563:Electrochemistry / Q000379:methods*; D017022:Flow Injection Analysis; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis*; D020280:Sertraline / Q000032:analysis*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline