title: Heteroaromatic side-chain analogs of pregabalin.
abstract: A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
authors.affiliation: PGRD Michigan Laboratories, Ann Arbor, MI 48105, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Schelkun
authors.forename: Po-wai
authors.initials: PW
authors.lastname: Yuen
authors.forename: David J
authors.initials: DJ
authors.lastname: Wustrow
authors.forename: Jack
authors.initials: J
authors.lastname: Kinsora
authors.forename: Ti-Zhi
authors.initials: TZ
authors.lastname: Su
authors.forename: Mark G
authors.initials: MG
authors.lastname: Vartanian
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004195:Disease Models, Animal; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D051379:Mice; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D000069583:Pregabalin; D012640:Seizures / Q000517:prevention & control*; D013237:Stereoisomerism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid