title: Physical activity in leisure-time and risk of cancer: 14-year follow-up of 28,000 Danish men and women.
abstract: OBJECTIVE
  The preventive effect of physical activity on risk of cancer in general remains controversial. This study aimed at assessment of the associations between leisure- time physical activity and incidence of cancer in the general population of adult men and women.
  
  
  METHODS
  13,216 women and 18,718 men aged 20-93 years selected from the general population participated in a health examination including a questionnaire with information on physical activity, smoking, alcohol intake, postmenopausal hormones, and socioeconomic status. Incident cases of cancers where recorded during a follow-up period of 14 years. The six most frequent cancer cases in both sexes were included in this analysis.
  
  
  RESULTS
  A highly significant inverse association was seen between vigorous physical activity in leisure time and cancer of the ovary, adjusted rate ratio being 0.33 (95% CI 0.16-0.67; p = 0.001) for the most physical active women. In men there was a highly significant increase for non-melanoma skin cancer, with adjusted rate ratio of 1.72 (95% CI 1.23-2.40; p = 0.001), for the most active men and vigorous activity was associated with a non-significant lower risk of colon cancer, the adjusted rate ratio being 0.72 (95% CI 0.47-1.11; p = 0.06).
  
  
  CONCLUSIONS
  Generally, there were no, or only weakly, inverse associations between physical activity in leisure time and incidence of cancer, except for cancer of the ovary.
authors.affiliation: The Copenhagen City Heart Study, Epidemiological Research Unit, Bispebjerg University Hospital, Denmark. peter@schnohr.dk
authors.forename: Peter
authors.initials: P
authors.lastname: Schnohr
authors.forename: Morten
authors.initials: M
authors.lastname: Grønbaek
authors.forename: Liselotte
authors.initials: L
authors.lastname: Petersen
authors.forename: Hans Ole
authors.initials: HO
authors.lastname: Hein
authors.forename: Thorkild I A
authors.initials: TI
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003718:Denmark / Q000453:epidemiology; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007899:Leisure Activities; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D017698:Postmenopause; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires