Therapeutic targets in Paracoccidioides brasiliensis: post-transcriptome perspectives.
The rise in antifungal resistance, observed as a result of the increasing numbers of immunocompromised patients, has made the discovery of new targets for drug therapy imperative. The description of the Paracoccidioides brasiliensis transcriptome has allowed us to find alternatives to refine current therapy against paracoccidioidomycosis. We used comparative analysis of expressed sequence tags to find promising drug targets that have been addressed in other pathogens. We divided the analysis into six different categories, based on the involvement of the targeted mechanisms in the cell: i) cell wall construction, ii) plasma membrane composition, iii) cellular machinery, iv) cellular metabolism, v) signaling pathways, and vi) other essential processes. Through this approach, it has been possible to infer strategies to develop alternative drugs against this pathogen.
Amaral
André Corrêa
AC
Departamento de Biologia Celular, IB, Universidade de Brasília, Brasília, DF, Brazil.
Fernandes
Larissa
L
Galdino
Alexsandro Sobreira
AS
Felipe
Maria Sueli Soares
MS
Soares
Célia Maria de Almeida
CM
Pereira
Maristela
M
D000935:Antifungal Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D015195:Drug Design; D020224:Expressed Sequence Tags; D006801:Humans; D010228:Paracoccidioides / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
D000935:Antifungal Agents