A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction.
Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl-NaI under microwave irradiation.
Kazmaier
Uli
U
Institut für Organische Chemie, Universität des Saarlandes, D-66123 Saarbrücken, Germany. u.kazmaier@mx.uni-saarland.de
Ackermann
Stefanie
S
D008872:Microwaves; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D013237:Stereoisomerism; D013844:Thiazoles / Q000138:chemical synthesis*
D010455:Peptides; D013844:Thiazoles