title: [Investigations of pyrazine derivatives. Part XXVII. Synthesis and tuberculostatic activity of some 6-alkoxypyrazine-2-carbotioamids].
abstract: It was found that reaction of sodium alcoholates and cyanopyrazine yields alkoxypyrazine-nitriles. In heterogenic reaction both 2-alkylimidesters-6-chloropyrazine or 2-alkylimidoesters-6-alkoxypyrazine can be obtained dependent. This is dependent on quantity of alcohol used for reaction. Final products, alkoxypyrazinethioamides were tested for tuberculostatic activity (MIC within 31-500 mcg/cm3).
authors.affiliation: Zaklad Chemii Organicznej, Akademia Medyczna, ul. K. Marksa 107, 80-416 Gdańsk.
authors.forename: B
authors.initials: B
authors.lastname: Milczarska
authors.forename: H
authors.initials: H
authors.lastname: Foks
authors.forename: M
authors.initials: M
authors.lastname: Janowiec
authors.forename: Z
authors.initials: Z
authors.lastname: Zwolska-Kwiek
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D008826:Microbial Sensitivity Tests; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D011719:Pyrazines