title: Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer.
abstract: The relationship between lipid soluble antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response were examined in healthy subjects (n = 14), patients with benign prostate hyperplasia BPH (n = 20), localized (n = 40) and metastatic (n = 38) prostate cancer. Prostate cancer patients had higher concentrations of malondialdehyde (p < 0.05) and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and beta-carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had a higher Gleason score (p < 0.01) and had more hormonal treatment, but lower concentrations of PSA (p < 0.05), alpha-tocopherol (p < or = 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, PSA was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (rs= 0.353, p = 0.002). C-reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (rs= -0.263, p = 0.020) and lycopene (rs= -0.269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: Ahmed S K
authors.initials: AS
authors.lastname: Almushatat
authors.forename: Dinesh
authors.initials: D
authors.lastname: Talwar
authors.forename: Peter A
authors.initials: PA
authors.lastname: McArdle
authors.forename: Cathy
authors.initials: C
authors.lastname: Williamson
authors.forename: Naveed
authors.initials: N
authors.lastname: Sattar
authors.forename: Denis St J
authors.initials: DS
authors.lastname: O'Reilly
authors.forename: Mark A
authors.initials: MA
authors.lastname: Underwood
authors.forename: Donald C
authors.initials: DC
authors.lastname: McMillan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000975:Antioxidants / Q000032:analysis*; D002338:Carotenoids / Q000097:blood*; D016022:Case-Control Studies; D018450:Disease Progression; D006801:Humans; D007249:Inflammation; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D018384:Oxidative Stress; D011470:Prostatic Hyperplasia / Q000276:immunology / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000503:physiopathology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D000975:Antioxidants; D002338:Carotenoids; D008315:Malondialdehyde