title: Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases.
abstract: OBJECTIVE
  The objective of this study was to assess the role of stereotactic radiosurgery in the management of newly diagnosed multiple intracranial metastases from known primary cancer locations.
  
  
  METHODS
  Fifty (29 women and 21 men) patients received radiosurgery for newly diagnosed 3 or more metastatic brain tumors. Their mean age was 53 years. Lung cancer was the most common primary cancer (66%).
  
  
  RESULTS
  Arrest in the growth of irradiated tumors was achieved in 41 (82%) patients. Eight patients (16%) required further intervention for tumors in other brain locations. Mean survival after diagnosis of brain disease was 12 months and the brain disease-controlled period was 19 months. The period of brain disease control prolonged (P=.03) with decreasing tumor volumes (<10 mL). Control of treated tumors positively affected survival after diagnosis of brain disease (P=.0001).
  
  
  CONCLUSIONS
  Radiosurgery as an adjuvant improves survival in patients with cancer who have newly diagnosed multiple intracranial metastases by arresting the growth of tumors.
authors.affiliation: Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA. ajawah@lsuhsc.edu
authors.forename: Ajay
authors.initials: A
authors.lastname: Jawahar
authors.forename: Mark
authors.initials: M
authors.lastname: Shaya
authors.forename: Peter
authors.initials: P
authors.lastname: Campbell
authors.forename: Federico
authors.initials: F
authors.lastname: Ampil
authors.forename: Brian K
authors.initials: BK
authors.lastname: Willis
authors.forename: Donald
authors.initials: D
authors.lastname: Smith
authors.forename: Anil
authors.initials: A
authors.lastname: Nanda
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D017567:Karnofsky Performance Status; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome