Bilateral primary orbital non-Hodgkin's lymphoma in a patient with scleroderma: a case report.
Orbital presentation of non-Hodgkin's Lymphoma (NHL) is uncommon but occurs both as the only site of disease and as a site of recurrence. Primary orbital NHLs are usually low-grade, and mostly extranodal marginal zone/mucosa associated lymphoid tissue B-cell neoplasms. They are commonly associated with chronic inflammatory conditions. The issue of bilaterality in orbital lymphoma is not very common. The onset of malignant lymphoproliferation may precede, follow, or exist simultaneously with scleroderma. Different treatment modalities were applied in orbital NHL such as surgery, radiation therapy, chemotherapy or both. We report a 57-year-old man with scleroderma presenting with eyelid hernias who had biopsy-proven marginal zone NHL, successfully treated with radiotherapy and combined chemotherapy, and also review the literature.
Alacacioglu
Inci
I
Division of Hematology, Dokuz Eylul University School of Medicine, Inciralti Izmir, Turkey.
Ozcan
Mehmet Ali
MA
Kocak
Nilufer
N
Demiral
Ayse
A
Piskin
Ozden
O
Demirkan
Fatih
F
Ozsan
Guner Hayri
GH
Saatci
Ali Osman
AO
Undar
Bulent
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002452:Cell Count; D005141:Eyelid Diseases / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D012074:Remission Induction; D045745:Scleroderma, Limited / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D016896:Treatment Outcome