title: [Recombination within the human leucocyte antigen].
abstract: Understanding with greater clearness the characteristics of recombination within the human leucocyte antigen(HLA) is of deep significance to gaining an insight into the evolutionary process of shaping HLA allelic diversity and ultimately the human resistance against diverse pathogens. Family studies and statistical analysis of recombination have provided estimations of recombination fractions across the major histocompatibility complex and have identified the potential recombination hotspots. Other characteristics such as haplotype specificity and sequence motifs have been intensively studied. The recombination fractions, hotspots and other characters are reviewed in this paper.
authors.affiliation: Department of Immunology, Affiliated Hospital for Academy of Military Medical Sciences, National Center of Biomedical Analysis Lab of Immunoassay, Beijing, 100039 PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Luo
authors.forename: Yu-ying
authors.initials: YY
authors.lastname: Sun
authors.forename: Yong-zhi
authors.initials: YZ
authors.lastname: Xi
mesh_terms: D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D011995:Recombination, Genetic / Q000235:genetics*
chemical_list: D006680:HLA Antigens