title: Job strain and autonomic indices of cardiovascular disease risk.
abstract: BACKGROUND
  Despite the epidemiological evidence linking job strain to cardiovascular disease, more insight is needed into the etiologic mechanisms. This, in turn, would help to more precisely identify risk.
  
  
  METHODS
  We measured Job Strain using the Job Content Questionnaire, 8/day diary reports, and nationally standardized occupational code linkage, as well as autonomic regulation utilizing heart rate variability including spectral-derived components and QT interval variability in 36 healthy mid-aged males with varying strain jobs. The subjects wore Holter-monitors for 48 hr; this included a work and rest day.
  
  
  RESULTS
  Job strain (P = 0.02) and low decision latitude (P = 0.004) were associated with a reduction in cardiac vagal control (HFP) persisting throughout the 48 hr. Job strain was also associated with elevations in sympathetic control during working hours (P = 0.003).
  
  
  CONCLUSIONS
  The disturbed cardiovascular regulatory pattern associated with job strain may help explain the increased risk of cardiovascular diseases linked with occupational exposure.
authors.affiliation: Department of Physical Therapy, School of Health and Environment, University of Massachusetts, Lowell, Massachusetts 01854, USA. Sean_Collins@uml.edu
authors.forename: Sean M
authors.initials: SM
authors.lastname: Collins
authors.forename: Robert A
authors.initials: RA
authors.lastname: Karasek
authors.forename: Kevin
authors.initials: K
authors.lastname: Costas
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D003657:Decision Making; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D016272:Occupational Health; D013315:Stress, Psychological; D014630:Vagus Nerve / Q000502:physiology