CD4+CD25+-regulatory T cells from mouse to man.
Immunological tolerance is one of the fundamental concepts of the immune system. During the past decade, CD4+CD25+-regulatory T cells have emerged as key players in the development of tolerance to autoantigens as well as to foreign antigens. Still many questions remain illusive regarding the basic properties of CD4+CD25+-regulatory T cells. This review aims to recapitulate some of the current understandings about the phenotype, function and clinical relevance of murine and human CD4+CD25+-regulatory T cells.
Wing
K
K
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. kajsa.wing@rheuma.gu.se
Suri-Payer
E
E
Rudin
A
A
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D010641:Phenotype; D015375:Receptors, Interleukin-2 / Q000032:analysis* / Q000276:immunology
D015375:Receptors, Interleukin-2