title: Obese subjects with heart failure have lower N-terminal pro-brain natriuretic peptide plasma levels irrespective of aetiology.
abstract: N-terminal pro-brain natriuretic peptide (NT-proBNP) may be useful in the diagnosis of heart failure and ventricular dysfunction. Obesity is an independent cardiovascular risk factor. The purpose of this study was to measure NT-proBNP plasma levels in obese and non-obese subjects with heart failure and to compare levels in subjects with ischaemic and dilated aetiology. In this study, obese subjects had 63% lower NT-proBNP plasma levels than non-obese subjects (p < 0.01). In multivariate analysis, BMI was inversely associated with NT-proBNP plasma levels (p < 0.05) and a 17% decrease in natriuretic peptide levels was attributed to obesity (p < 0.036). When we analyzed data according to the aetiology of heart failure, we found that both groups (ischaemic and dilated) had a 65% decrease in NT-proBNP plasma levels in obese subjects compared to non-obese subjects.
authors.affiliation: Department of Cardiology, Research Center La Fe Hospital, José María Haro, Valencia, Spain. rivera_jmi@gva.es
authors.forename: Miguel
authors.initials: M
authors.lastname: Rivera
authors.forename: Raquel
authors.initials: R
authors.lastname: Cortés
authors.forename: Antonio
authors.initials: A
authors.lastname: Salvador
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
authors.forename: Fernando García
authors.initials: FG
authors.lastname: de Burgos
authors.forename: Rafael
authors.initials: R
authors.lastname: Payá
authors.forename: Manuel
authors.initials: M
authors.lastname: Portolés
authors.forename: Raquel
authors.initials: R
authors.lastname: Taléns-Visconti
authors.forename: Luis
authors.initials: L
authors.lastname: Martinez-Dolz
authors.forename: Ricardo
authors.initials: R
authors.lastname: Valero
authors.forename: Begoña
authors.initials: B
authors.lastname: Sevilla
authors.forename: Vicente
authors.initials: V
authors.lastname: Climent
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000150:complications*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain