Lack of Delta like 1 and 4 expressions in nude thymus anlages.
Notch signaling is required for the early steps in T cell development. However, distribution of Notch ligands in the thymus anlages is not clear. We investigated the expressions of Delta like (Dll) 1 and Dll4 in the mouse thymus anlages. In the normal thymus anlages on embryonic day 13, Dll4 is strongly expressed throughout the epithelial region, but Dll1 is expressed only in scattered cells. In contrast, epithelial cells of the nude thymus anlages express neither Dll1 nor Dll4. These results indicate that expressions of Dll1 and Dll4 in thymic epithelial cells are regulated by Foxn1 transcriptional factor.
Tsukamoto
Noriyuki
N
Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi-cho, Funai-gun, Kyoto 629-0392, Japan.
Itoi
Manami
M
Nishikawa
Mitsuo
M
Amagai
Takashi
T
D000818:Animals; D002478:Cells, Cultured; D004268:DNA-Binding Proteins; D004628:Embryonic Structures; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D017403:In Situ Hybridization; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; D014157:Transcription Factors; C090140:Whn protein; C064045:delta protein