title: Modeling control strategies of respiratory pathogens.
abstract: Effectively controlling infectious diseases requires quantitative comparisons of quarantine, infection control precautions, case identification and isolation, and immunization interventions. We used contact network epidemiology to predict the effect of various control policies for a mildly contagious disease, such as severe acute respiratory syndrome, and a moderately contagious disease, such as smallpox. The success of an intervention depends on the transmissibility of the disease and the contact pattern between persons within a community. The model predicts that use of face masks and general vaccination will only moderately affect the spread of mildly contagious diseases. In contrast, quarantine and ring vaccination can prevent the spread of a wide spectrum of diseases. Contact network epidemiology can provide valuable quantitative input to public health decisionmaking, even before a pathogen is well characterized.
authors.affiliation: Division of Mathematical Modeling, University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada. babak.pourbohloul@bccdc.ca
authors.forename: Babak
authors.initials: B
authors.lastname: Pourbohloul
authors.forename: Lauren Ancel
authors.initials: LA
authors.lastname: Meyers
authors.forename: Danuta M
authors.initials: DM
authors.lastname: Skowronski
authors.forename: Mel
authors.initials: M
authors.lastname: Krajden
authors.forename: David M
authors.initials: DM
authors.lastname: Patrick
authors.forename: Robert C
authors.initials: RC
authors.lastname: Brunham
mesh_terms: D001955:British Columbia / Q000453:epidemiology; D004196:Disease Outbreaks / Q000517:prevention & control*; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control; D017757:Infectious Disease Transmission, Professional-to-Patient / Q000517:prevention & control; D008397:Masks / Q000592:standards; D008954:Models, Biological; D010356:Patient Isolation / Q000592:standards; D011634:Public Health / Q000379:methods; D011790:Quarantine / Q000592:standards; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control* / Q000635:transmission; D014505:Urban Population