title: Prediction of early and late recurrence in patients with breast carcinoma.
abstract: BACKGROUND
  The clinical course of patients with recurrent breast carcinoma varies greatly. Better characterization of an individual's clinical course for recurrent patients may aid in their clinical management. However, less attention has been paid to evaluating factors associated with the timing of recurrence in those patients. We investigated the clinicopathological indicators that determined the timing of recurrence by univariate and multivariate analysis.
  
  
  METHODS
  We retrospectively examined data on 1428 curatively treated Japanese patients who had been surgically treated for breast cancer between 1983 and 2002. From these, 244(17.1%)who had clearly died of recurrence were entered into this study.
  
  
  RESULTS
  By univariate analysis, tumor size, estrogen receptor(ER), and progesterone receptor(PgR)were significantly correlated with time to recurrence. Multivariate analysis indicated that the time between operation and recurrence was independently influenced by ER and PR.
  
  
  CONCLUSIONS
  Our research shows that ER and PgR are independent factors influencing the timing of recurrence of breast carcinoma after curative resection. The combined analysis of these independent factors facilitates prediction of the time to recurrence for each patient.
authors.affiliation: Department of Surgery, Oita Prefectural Hospital, Bunyo 476, Oita 870-8511, Japan. t3996@go2.enjoy.ne.jp
authors.forename: Hideya
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Kohichi
authors.initials: K
authors.lastname: Tsuji
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ueo
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone