title: Virology, pathology, and clinical manifestations of West Nile virus disease.
abstract: West Nile virus (WNV) causes epidemics of febrile illness, meningitis, encephalitis, and flaccid paralysis. Since it was first detected in New York City in 1999, and through 2004, >16,000 WNV disease cases have been reported in the United States. Over the past 5 years, research on WNV disease has expanded rapidly. This review highlights new information regarding the virology, clinical manifestations, and pathology of WNV disease, which will provide a new platform for further research into diagnosis, treatment, and possible prevention of WNV through vaccination.
authors.affiliation: Centers for Disease Control and Prevention, Fort Collins, Colorado 80526, USA. ebh2@cdc.gov
authors.forename: Edward B
authors.initials: EB
authors.lastname: Hayes
authors.forename: James J
authors.initials: JJ
authors.lastname: Sejvar
authors.forename: Sherif R
authors.initials: SR
authors.lastname: Zaki
authors.forename: Robert S
authors.initials: RS
authors.lastname: Lanciotti
authors.forename: Amy V
authors.initials: AV
authors.lastname: Bode
authors.forename: Grant L
authors.initials: GL
authors.lastname: Campbell
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D006801:Humans; D014765:Viral Vaccines / Q000627:therapeutic use; D014901:West Nile Fever / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000821:virology*; D014902:West Nile virus / Q000254:growth & development*
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines