The effect of hemodynamic changes induced by propofol induction on cerebral oxygenation in young and elderly patients.
OBJECTIVE
To investigate the difference of regional cerebral oxygen saturation (rSo2) decrease in response to the decrease in mean arterial blood pressure (MAP) in young and elderly patients.


METHODS
Prospective clinical study.


METHODS
Medical center hospital.


METHODS
Twenty-four American Society of Anesthesiologists physical status I and II patients, 12 of whom were young and the other 12 elderly, scheduled for elective surgery requiring general anesthesia. Patients received propofol 2 mg/kg (young patient group) and propofol 1.5 mg/kg (elderly patient group) as an induction drug.


METHODS
MAP and rSo2 were recorded continuously for 5 minutes after propofol administration.


RESULTS
MAP values at the second to fifth minutes and rSo2 at the second minute after propofol administration were significantly lower than baseline in both groups (P<.05). The rSo2 decrease was minimal, and the slopes of the rSo2 decrease in response to the MAP decrease in the young and elderly groups were 0.093+/-0.012 (P<.001) and 0.112+/-0.016 (P<.001) (mean+/-SEM), respectively.


CONCLUSIONS
After propofol induction, there was no difference between young and elderly patients in rSo2 decrease in response to the decrease in MAP.
Hung
Yu-Chun
YC
Department of Anesthesiology, Mackay Memorial Hospital, and Mackay Medicine, Nursing and Management College, Taipei, Taiwan, 10449.
Huang
Chun-Jen
CJ
Kuok
Chi Hang
CH
Chen
Chien-Chuan
CC
Hsu
Yung-Wei
YW
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D015742:Propofol / Q000494:pharmacology*; D011446:Prospective Studies
D018686:Anesthetics, Intravenous; D010100:Oxygen; D015742:Propofol