Pharmacological effects of Ukrain in rats and rabbits.
The effect of Ukrain administered in various doses on mean blood pressure (MAP) and breathing rate in rats and rabbits was evaluated. It was found that MAP was reduced and breathing rate increased significantly in both animal species. Maximum tolerated dose (MTD) of Ukrain was 10-fold higher in rats than in rabbits, and it amounted to 3.5 mg x kg(-1) and 0.35 mg x kg(-1), respectively. Possible clinical implications of these findings were discussed.
Remiszewska
M
M
Department of Pharmacology, Drug Institute, 30/34 Chełmska Str., 00-725 Warsaw, Poland.
Wutkiewicz
M
M
Jastrzebski
Z
Z
Czyzewska-Szafran
H
H
Danysz
A
A
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001600:Berberine Alkaloids; D001794:Blood Pressure / Q000187:drug effects*; D008297:Male; D020714:Maximum Tolerated Dose; D010617:Phenanthridines; D011817:Rabbits; D051381:Rats; D011921:Rats, Inbred WKY; D012119:Respiration / Q000187:drug effects*
D000470:Alkaloids; D001600:Berberine Alkaloids; D010617:Phenanthridines; C060921:ukrain