title: Responses across the gravity continuum: hypergravity to microgravity.
abstract: In response to hypergravity, it appears that the larger the animal, the greater the response, if present. Therefore, the response of a rat exceeds that of a mouse in the same hypergravity environment. When investigated in the microgravity environment of space flight, this appears to hold true. The lack of definitive data obtained in space for either species makes the extrapolation of the continuum to levels below Earth-gravity problematic. However, in systems where responses are detected for both space flight and acceleration by centrifugation, a gravitational continuum is present supporting the "principle of continuity". For those and similar systems, it appears that the use of hypergravity could be used to predict responses to space flight.
authors.affiliation: Life Sciences Division, NASA - Ames Research Center, Moffett Field, CA 94035, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Wade
mesh_terms: D000818:Animals; D001823:Body Composition; D001831:Body Temperature; D001835:Body Weight; D001842:Bone and Bones / Q000502:physiology; D002498:Centrifugation; D004734:Energy Metabolism; D006128:Growth; D006801:Humans; D018471:Hypergravity; D007107:Immune System / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000502:physiology; D014893:Weightlessness