Plasma coagulation factor VII activity and its correlates in healthy men.
OBJECTIVE
The aim of this study was to investigate the plasma coagulation factor VII activity and its correlates in healthy Australian men.


METHODS
Cross-sectional study.


METHODS
Free living subjects.


METHODS
A total of 139 healthy Australian males aged 20-55 y with widely varying intakes of individual fatty acids.


METHODS
The concentration of phospholipid fatty acids and the parameters of biochemistry were analysed by standard methods. Citrated plasma factor VII activity was measured by using the ACL 200 system with commercially available kits.


RESULTS
In the stepwise multiple regression, controlled for age, body mass index and dietary groups, the two most important variables of factor VII activity were selected in the forward entry model with R (2) = 0.474 and P < 0.0001 from 19 independent variables, which were significantly correlated with plasma factor VII activity in age-adjusted bivariate analysis where significance was considered at P < 0.01. Plasma factor VII activity was strongly negatively correlated with prothrombin time (PT) (Std. Coeff. -0.550), and significantly positively correlated with plasma phospholipid (PL) stearic acid (Std. Coeff. 0.285).


CONCLUSIONS
Increased factor VII activity was associated with shortening of PT. All types of fatty-acid concentrations of PLs were significantly positively correlated with factor VII activity; however, stearic acid was more potent than other fatty acids in healthy Australian men.


BACKGROUND
Meat Research Corporation of Australia.
Li
D
D
Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. duoli@zju.edu.cn
Turner
A
A
Sinclair
A J
AJ
D000328:Adult; D003430:Cross-Sectional Studies; D004032:Diet; D014676:Diet, Vegetarian; D005167:Factor VII / Q000378:metabolism*; D005227:Fatty Acids / Q000008:administration & dosage* / Q000032:analysis*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D011517:Prothrombin Time; D012044:Regression Analysis; D013229:Stearic Acids / Q000008:administration & dosage / Q000032:analysis
D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D013229:Stearic Acids; C031183:stearic acid; D005167:Factor VII