title: Effectiveness of antiinfectives.
abstract: BACKGROUND
  Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality.
  
  
  METHODS
  First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-line therapy, consisting of a proton pump inhibitor, bismuth, metronidazole, and tetracycline, in the case of failure, is chosen as the most cost-effective method of H. pylori eradication.
  
  
  CONCLUSIONS
  The effectiveness of these antiinfectives is limited by lack of compliance with treatment regimens, and increasing antibiotic resistance.
authors.affiliation: Adelaide and Meath Hospital, and Trinity College, Dublin, Ireland.
authors.forename: Ramona
authors.initials: R
authors.lastname: McLoughlin
authors.forename: Colm
authors.initials: C
authors.lastname: O'Morain
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000188:drug therapy*; D006801:Humans; D010349:Patient Compliance; D054328:Proton Pump Inhibitors; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors