title: Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines.
abstract: To demonstrate the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St. Luke's Medical Center in Quezon City, between 1999 and 2001 in Metro Manila, and adjoining provinces the Philippines, with a laboratory-confirmed dengue virus infection were evaluated. One third of the patients had DHF, and most of these patients were without shock. Restlessness, epistaxis, and abdominal pain were more associated with DHF. The platelet count was significantly lower in the DHF group than in the DF group before and after defervescence. In the DHF patients, the hematocrit was significantly increased before defervescence, and decreased the day after due to administration of intravenous fluid. Coagulation abnormalities associated with most DHF patients were thrombocytopenia and an increased fibrinolysis, but not disseminated intravascular coagulation. We present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and consequently earlier appropriate treatment of dengue virus infections.
authors.affiliation: Department of Pediatrics, and Research and Biotechnology Division, St. Luke's Medical Center, Quezon City, The Philippines.
authors.forename: Celia C
authors.initials: CC
authors.lastname: Carlos
authors.forename: Kazunori
authors.initials: K
authors.lastname: Oishi
authors.forename: Maria T D D
authors.initials: MT
authors.lastname: Cinco
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Mapua
authors.forename: Shingo
authors.initials: S
authors.lastname: Inoue
authors.forename: Deu John M
authors.initials: DJ
authors.lastname: Cruz
authors.forename: Mary Ann M
authors.initials: MA
authors.lastname: Pancho
authors.forename: Carol Z
authors.initials: CZ
authors.lastname: Tanig
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Matias
authors.forename: Kouichi
authors.initials: K
authors.lastname: Morita
authors.forename: Filipinas F
authors.initials: FF
authors.lastname: Natividad
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nagatake
mesh_terms: D000293:Adolescent; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006400:Hematocrit; D006402:Hematologic Diseases / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010679:Philippines / Q000453:epidemiology; D010976:Platelet Count; D019595:Severe Dengue / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*