LRP 1 B functions as a receptor for Pseudomonas exotoxin.
Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor.
Pastrana
Diana V
DV
Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, MD 20892-4263, USA.
Hanson
Alison J
AJ
Knisely
Jane
J
Bu
Guojun
G
Fitzgerald
David J
DJ
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000633:toxicity; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004591:Electrophoresis, Polyacrylamide Gel; D018014:Gene Transfer Techniques; D008567:Membranes, Artificial; D009154:Mutation / Q000235:genetics; D011145:Polyvinyls; D011485:Protein Binding / Q000187:drug effects; D011500:Protein Synthesis Inhibitors / Q000378:metabolism* / Q000633:toxicity; D011973:Receptors, LDL / Q000378:metabolism*; D018675:Toxicity Tests; D005465:Fluorocarbon Polymers
D001426:Bacterial Proteins; D008567:Membranes, Artificial; D011145:Polyvinyls; D011500:Protein Synthesis Inhibitors; D011973:Receptors, LDL; C434476:LRP1B protein, human; C111749:pseudomonas exoprotein A protein, Pseudomonas aeruginosa; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers