Synthesis, spectroscopy and antiproliferative activity of cis- and trans-platinum(II) complexes with diethyl (pyridin-4-ylmethyl)phosphate. X-ray crystal structure of trans-Pt(II) complex.
Preparations of cis- and trans-platinum(II) complexes of diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe) have been described. These complexes were identified and characterized by far-IR, 1H NMR, 13C NMR, 31P NMR and 195Pt NMR and microanalyses. The crystal and molecular structure of trans-platinum(II) complex i.e., trans-[PtCl2(4-pmOpe)2] was determined by the X-ray diffraction. Novel complexes were assayed for their potential antiproliferative effect against HT 29 (colorectal adenocarcinoma) and A 549 (non-small cell lung cancer) cell lines as well as normal human peripheral blood lymphocytes. The results obtained indicate that novel analogues of cis-diamminedichloroplatinum(II) cause inhibition of cells growth which suggest that they could be chemotherapeutic drugs in the future.
Kalinowska
Urszula
U
Department of Bioinorganic Chemistry, Medical University, Muszyńskiego 1, 90-151 Łódź, Poland.
Matławska
Ksenia
K
Checińska
Lilianna
L
Domagała
Małgorzata
M
Kontek
Renata
R
Osiecka
Regina
R
Ochocki
Justyn
J
D000230:Adenocarcinoma / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010755:Organophosphates / Q000737:chemistry*; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
D010755:Organophosphates; D017671:Platinum Compounds; D011725:Pyridines; C505745:diethyl (pyridin-4-ylmethyl)phosphate