title: Resolution of hypophosphatemia is associated with recovery of hepatic function in children with fulminant hepatic failure.
abstract: Fulminant hepatic failure (FHF) is a rare but often fatal disease in children. Clinical and laboratory predictors of liver regeneration and recovery, however, have not been well established. We hypothesized that hypophosphatemia may indicate recovery of liver synthetic function in children with FHF. We retrospectively reviewed the medical records of children with FHF who were admitted to UCLA and recovered hepatic function either spontaneously or by liver transplantation (LTx). Serum phosphate (Ph) and prothrombin time or international normalized ratio (INR) were compared over the patient's clinical course. Records of 39 children who spontaneously recovered experienced profound hypophosphatemia that resolved as liver synthetic function improved. Similar patterns were seen in the 84 children who recovered after LTx. We found that hypophosphatemia precedes the recovery of liver synthetic function in children with FHF who recovered with or without transplantation, and that Ph levels return to normal as liver synthetic function improves. These data suggest that hypophosphatemia may be a useful laboratory indicator of recovering liver function in children with FHF.
authors.affiliation: Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Texas and Memorial Hermann Children's Hospital, Houston, Texas 77030-0708, USA. Ruben.E.Quiros@uth.tmc.edu
authors.forename: Rubén E
authors.initials: RE
authors.lastname: Quirós-Tejeira
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Molina
authors.forename: Lirona
authors.initials: L
authors.lastname: Katzir
authors.forename: Angela
authors.initials: A
authors.lastname: Lie
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Vargas
authors.forename: Marvin E
authors.initials: ME
authors.lastname: Ament
authors.forename: Sue V
authors.initials: SV
authors.lastname: McDiarmid
authors.forename: Martín G
authors.initials: MG
authors.lastname: Martín
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000503:physiopathology*; D017114:Liver Failure, Acute / Q000097:blood* / Q000503:physiopathology; D016031:Liver Transplantation; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers