title: Effect of short-term treatment with pravastatin on cytokines and cytokine receptors in patients with chronic heart failure due to ischemic and nonischemic disease.
abstract: The antiinflammatory effect of lipoproteins through neutralization of circulating endotoxin has questioned the safety of lipid-lowering drugs in chronic heart failure (CHF). We measured serum levels of interleukin-6, tumor necrosis factor (TNF)-alpha, and soluble TNF-alpha receptors 1 and 2 before and after 1-month treatment with pravastatin 40 mg in 58 patients with CHF. Short-term treatment with pravastatin attenuated the immune response in patients with CHF due to ischemic or nonischemic etiology.
authors.affiliation: Department of Cardiology, University Hospital, Antwerp, Belgium.
authors.forename: Viviane M
authors.initials: VM
authors.lastname: Conraads
authors.forename: Johan M
authors.initials: JM
authors.lastname: Bosmans
authors.forename: Annemie J
authors.initials: AJ
authors.lastname: Schuerwegh
authors.forename: Luc S
authors.initials: LS
authors.lastname: De Clerck
authors.forename: Chris H
authors.initials: CH
authors.lastname: Bridts
authors.forename: Floris L
authors.initials: FL
authors.lastname: Wuyts
authors.forename: Wim J
authors.initials: WJ
authors.lastname: Stevens
authors.forename: Christiaan J
authors.initials: CJ
authors.lastname: Vrints
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016207:Cytokines / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000175:diagnosis; D017035:Pravastatin / Q000008:administration & dosage*; D011336:Probability; D011446:Prospective Studies; D018121:Receptors, Cytokine / Q000187:drug effects* / Q000378:metabolism; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D018121:Receptors, Cytokine; D017035:Pravastatin