Ferula hermonis impairs sexual behavior in hormone-primed female rats.
The influence of Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with F. hermonis extract acutely (30 and 60 mg/kg) or subchronically (1 and 10 mg/kg daily for 10 consecutive days). A significant reduction in lordosis responses was observed in rats after acute (60 mg/kg) or subchronic (1 and 10 mg/kg) administration of the plant extract. Similarly, a decrease in proceptive behaviors was exhibited by F. hermonis treated rats in comparison with EB+P controls. No difference was found in the patterns of paced mating behavior between control and treated animals. The present results demonstrate that the acute or repeated ingestion of F. hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats.
Zanoli
Paola
P
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy. zanoli.paola@unimore.it
Zavatti
Manuela
M
Rivasi
Marianna
M
Baraldi
Mario
M
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005309:Ferula / Q000737:chemistry*; D010052:Ovariectomy / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects*; D011187:Posture / Q000502:physiology; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D004338:Drug Combinations; D010936:Plant Extracts; D011374:Progesterone; D004958:Estradiol