Congenital MLL-positive B-cell acute lymphoblastic leukemia (B-ALL) switched lineage at relapse to acute myelocytic leukemia (AML) with persistent t(4;11) and t(1;6) translocations and JH gene rearrangement.
Congenital acute leukemia is a rare form of childhood leukemia, in which lineage conversion at relapse is very rarely reported. Here we describe a case of congenital B-cell acute lymphoblastic leukemia (B-ALL) with t(4;11) and t(1;6) translocations, which at relapse underwent a switch to monocytic lineage with persistence of the original cytogenetic translocations and clonal rearrangement of the JH gene. Similar to the other described cases of congenital acute leukemia with lineage conversion, our case had a MLL gene rearrangement and followed an aggressive clinical course.
Jiang
Jie-Gen
JG
Department of Pathology, Columbia University, New York, NY 10032, USA.
Roman
Elizabeth
E
Nandula
Subhadra V
SV
Murty
Vundavalli V S
VV
Bhagat
Govind
G
Alobeid
Bachir
B
D002051:Burkitt Lymphoma / Q000151:congenital / Q000175:diagnosis / Q000235:genetics*; D019070:Cell Lineage; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D020732:Cytogenetic Analysis; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007144:Immunoglobulin J-Chains / Q000235:genetics; D016130:Immunophenotyping; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012008:Recurrence; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains; D007144:Immunoglobulin J-Chains; C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase