Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men.
BACKGROUND
Plasma concentrations of long-chain n-3 polyunsaturated fatty acids are lower in vegetarians and in vegans than in omnivores. No data are available on whether these concentrations differ between long- and short-term vegetarians and vegans.


OBJECTIVE
We compared plasma fatty acid composition in meat-eaters, vegetarians, and vegans and examined whether the proportions of eicosapentaenoic acid (20:5n-3; EPA), docosapentaenoic acid (22:5n-3; DPA), and docosahexaenoic acid (22:6n-3; DHA) were related to the subjects' duration of adherence to their diets or to the proportions of plasma linoleic acid (18:2n-6; LA) and alpha-linolenic acid (18:3n-3; ALA).


METHODS
The present cross-sectional study included 196 meat-eating, 231 vegetarian, and 232 vegan men in the United Kingdom. Information on anthropometry, diet, and smoking habits was obtained through a questionnaire. Total fatty acid composition in plasma was measured.


RESULTS
The proportions of plasma EPA and DHA were lower in the vegetarians and in the vegans than in the meat-eaters, whereas only small differences were seen for DPA. Plasma EPA, DPA, and DHA proportions were not significantly associated with the duration of time since the subjects became vegetarian or vegan, which ranged from <1 y to >20 y. In the vegetarians and the vegans, plasma DHA was inversely correlated with plasma LA.


CONCLUSIONS
The proportions of plasma long-chain n-3 fatty acids were not significantly affected by the duration of adherence to a vegetarian or vegan diet. This finding suggests that when animal foods are wholly excluded from the diet, the endogenous production of EPA and DHA results in low but stable plasma concentrations of these fatty acids.
Rosell
Magdalena S
MS
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom. magdalena.rosell@cancer.org.uk
Lloyd-Wright
Zouë
Z
Appleby
Paul N
PN
Sanders
Thomas A B
TA
Allen
Naomi E
NE
Key
Timothy J
TJ
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D014676:Diet, Vegetarian; D004281:Docosahexaenoic Acids / Q000097:blood; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; C077446:Pikasol; D004281:Docosahexaenoic Acids; C026219:docosapentaenoic acid