title: [Effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy].
abstract: BACKGROUND
  The purpose of this study is to examine the effects of neutrophil elastase inhibitor on postoperative cytokine levels in patients after esophagectomy.
  
  
  METHODS
  Fifteen patients were divided into two groups; group 1: 9 patients receiving neutrophil elastase inhibitor (0.2 mg x kg(-1) x hr(-1) from the admission to ICU to extubation), group 2: 6 patients as a control. We measured neutrophil elastase activity, interleukin 1-beta, interleukin 6 and interleukin 8 preoperatively, just after the admission to ICU, and 24, 48 and 72 hours after the surgery.
  
  
  RESULTS
  There were significant differences in neutrophil elastase activity and interleukin 8 in group 1 24 hours after the surgery, compared with those in group 2. The time necessary for mechanical ventilation in group 1 was shorter than that in group 2 (group 1: 44.7 +/- 24.7 hrs, group 2: 112.8 +/- 90.3 hrs, P = 0.048).
  
  
  CONCLUSIONS
  The administration of neutrophil elastase inhibitor may be useful for patients after esophagectomy to reduce overexpression of plasma cytokine levels after surgery.
authors.affiliation: Department of General Surgical Science and Gunma University, Graduate School of Medicine, Maebashi 371-8511.
authors.forename: Ei
authors.initials: E
authors.lastname: Yamaki
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Ogata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hinohara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kadoi
authors.forename: Fumio
authors.initials: F
authors.lastname: Kunimoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D016207:Cytokines / Q000097:blood*; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D019272:Leukocyte Elastase / Q000097:blood; D008171:Lung Diseases / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D011184:Postoperative Period; D012121:Respiration, Artificial; D015843:Serpins / Q000008:administration & dosage*; D013449:Sulfonamides / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D016207:Cytokines; D016209:Interleukin-8; D015843:Serpins; D013449:Sulfonamides; C069195:sivelestat; D019272:Leukocyte Elastase; D005998:Glycine