title: [Successful management of a patient with rhabdomyolysis and marked elevation of serum creatine kinase level].
abstract: We experienced successful management of a patient with severe rhabdomyolysis by conservative treatment. A 41-year-old man developed Stanford-A-type acute aortic dissection and underwent an emergent replacement of the aortic root and arch. After the weaning from cardiopulmonary bypass, his left femoral artery was found non-pulsatile, probably due to extension of the aortic dissection, and femoro-femoral artery bypass surgery was added. Estimated ischemia time of the lower extremities was 7 hours. On admission to the intensive care unit (ICU), his left lower extremity showed signs of reperfusion injury accompanied with marked elevation of serum creatine kinase (12,397 IU x l(-1)) and myoglobin (19,980 ng x ml(-1)), and impaired oxygenation (a ratio of PaO2 to FIO2, 130 mmHg). We performed (1) moderately aggressive infusion treatment, (2) maintenance of hyperdynamic states using catecholamine, (3) diuresis therapy using atrial natriuretic peptide and furosemide, and (4) lung protective strategy. Although serum creatinine increased to 2.0 mg x dl(-1) on postoperative day (POD) 1, diuresis was maintained and the level of creatinine returned to normal on POD 6. He was extubated on POD 6 and discharged on POD 7. The early start of these combined therapies seems to have prevented acute renal failure without blood purification.
authors.affiliation: Department of Surgical Intensive Care Unit, National Cardiovascular Center, Osaka 565-8565.
authors.forename: Makiko
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Tachibana
authors.forename: Hideaki
authors.initials: H
authors.lastname: Imanaka
authors.forename: Muneyuki
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takauchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Inamori
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D000714:Anastomosis, Surgical; D000784:Aortic Dissection / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D003131:Combined Modality Therapy; D003402:Creatine Kinase / Q000097:blood*; D004630:Emergencies; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood*; D011182:Postoperative Care; D011183:Postoperative Complications; D015427:Reperfusion Injury / Q000150:complications*; D012206:Rhabdomyolysis / Q000209:etiology / Q000628:therapy*; D012720:Severity of Illness Index; D013577:Syndrome
chemical_list: D009211:Myoglobin; D003402:Creatine Kinase