title: Radial compression elasticity of single DNA molecules studied by vibrating scanning polarization force microscopy.
abstract: The radial compression properties of single DNA molecules have been studied using vibrating scanning polarization force microscopy. By imaging DNA molecules at different vibration amplitude set-point values, we obtain the correlations between radially applied force and DNA compression, from which the radial compressive elasticity can be deduced. The estimated elastic modulus is approximately 20-70 MPa under small external forces (<0.4 nN) and increases to approximately 100-200 MPa for large loads.
authors.affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
authors.forename: Xing-Fei
authors.initials: XF
authors.lastname: Zhou
authors.forename: Jie-Lin
authors.initials: JL
authors.lastname: Sun
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: An
authors.forename: Yun-Chang
authors.initials: YC
authors.lastname: Guo
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Fang
authors.forename: Chanmin
authors.initials: C
authors.lastname: Su
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xiao
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Huang
authors.forename: Min-Qian
authors.initials: MQ
authors.lastname: Li
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Shen
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
mesh_terms: D019245:Compressive Strength; D003198:Computer Simulation; D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D004548:Elasticity; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008846:Micromanipulation / Q000379:methods*; D018625:Microscopy, Atomic Force / Q000379:methods*; D008859:Microscopy, Polarization / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013314:Stress, Mechanical; D014732:Vibration
chemical_list: D004247:DNA