Use of prebiotics for inflammatory bowel disease.
The relevance of diet in both the pathogenesis and the therapy of inflammatory bowel disease is an evolving science. Disturbance of intestinal microflora (dysbiosis) is putatively a key element in the environmental component causing inflammatory bowel disease. Prebiotics are among the dietary components used in an attempt to counteract dysbiosis. Such predominantly carbohydrate dietary components exert effects on the luminal environment by physicochemical changes through pH alteration, by production of short chain fatty acids and by selectively promoting putatively 'health-beneficial' bacteria. The present review elaborates on some of the background rationale and mechanisms on the use of prebiotics. Additionally, published animal and human trials are discussed.
Szilagyi
Andrew
A
Division of Gastroenterology, Faculty of Medicine, The Sir Mortimer B Davis Jewish General Hospital, McGill University School of Medicine, Montreal, Canada.
D000818:Animals; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome