title: Relationships of soluble APO-1 (Fas/CD95) concentrations, obesity, and serum lipid parameters in healthy adults.
abstract: To investigate the relationships of apoptosis with obesity and lipid parameters, we measured serum soluble APO-1 (sAPO-1) concentrations, body mass index (BMI), and serum lipid profiles in 176 healthy adults. Serum sAPO-1 levels were measured by enzyme immunoassay. There were no significant differences in mean sAPO-1 concentrations between men and women, nor between subjects with and without obesity. However, women with high-density lipoprotein cholesterol (HDL-C) <50.2 mg/dl exhibited significantly higher sAPO-1 concentrations than those with HDL-C >50.2 mg/dl (ie, 45.6 +/- 10.4 pg/ml vs 31.5 +/- 11.3 pg/ml, p <0.05). Serum sAPO-1 concentrations averaged 46.8 +/- 10.7 pg/ml in women with serum triglyceride >137.4 mg/dl, which was significantly above the mean value (32.6 +/- 12.0 pg/ml, p <0.05) in those with serum triglyceride <137.4 mg/dl. Men with elevated sAPO-1 concentrations showed significantly higher waist-to-hip ratio (WHR) and total body fat (TBF) compared to those with diminished sAPO-1 levels, although no differences were noted in mean values of lipid profiles between the 2 groups of men. Serum sAPO-1 concentrations correlated significantly with HDL-C (r = - 0.41, p <0.05) and triglyceride (r = 0.35, p <0.05) in women and WHR (r = 0.25, p <0.05) and TBF (r = 0.21, p <0.05) in men. In conclusion, serum sAPO-1 appears to have an important relationship to serum lipid levels and body adiposity in healthy adults.
authors.affiliation: Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea. jwchoi@inha.ac.kr
authors.forename: Jong Weon
authors.initials: JW
authors.lastname: Choi
authors.forename: Soon Ki
authors.initials: SK
authors.lastname: Kim
mesh_terms: D050154:Adiposity; D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006262:Health; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D012727:Sex Characteristics; D012995:Solubility; D049629:Waist-Hip Ratio; D019014:fas Receptor / Q000097:blood* / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D019014:fas Receptor