title: Low incidence of hepatotoxicity in a cohort of HIV patients treated with lopinavir/ritonavir.
abstract: We describe the hepatotoxicity encountered in a cohort of HIV-positive patients treated with lopinavir/ritonavir. We used the database from the SCOLTA project, an on-line pharmacovigilance programme involving 25 Italian infectious disease centres. A total of 755 patients were followed, over a mean observation period of 16 months. The incidence of severe events was low despite the high prevalence of patients co-infected with hepatitis virus at enrollment.
authors.affiliation: I Divisione di Malattie Infettive, Ospedale Luigi Sacco, Milan, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonfanti
authors.forename: Elena
authors.initials: E
authors.lastname: Ricci
authors.forename: Giovanni
authors.initials: G
authors.lastname: Penco
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Orofino
authors.forename: Teresa
authors.initials: T
authors.lastname: Bini
authors.forename: Claudio
authors.initials: C
authors.lastname: Sfara
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Miccolis
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cristina
authors.forename: Tiziana
authors.initials: T
authors.lastname: Quirino
mesh_terms: D000293:Adolescent; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D019694:Hepatitis B, Chronic / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008107:Liver Diseases / Q000453:epidemiology; D061466:Lopinavir; D008297:Male; D008875:Middle Aged; D011358:Product Surveillance, Postmarketing; D011744:Pyrimidinones / Q000009:adverse effects*; D019438:Ritonavir / Q000009:adverse effects*
chemical_list: D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir