Transforming growth factor beta(2) increases in subretinal fluid in rhegmatogenous retinal detachment with subretinal strands.
OBJECTIVE
To compare transforming growth factor (TGF) beta(2) levels in subretinal fluid of rhegmatogenous retinal detachment with or without subretinal strand formation.


METHODS
We assessed total and mature TGF-beta(2) levels in subretinal fluid obtained from 24 eyes with rhegmatogenous retinal detachment using an enzyme-linked immunosorbent assay. Group I comprised 18 specimens from eyes without subretinal strands, while group II comprised 6 specimens from eyes with subretinal strands.


RESULTS
Total and mature TGF-beta(2) levels were higher in group II than in group I (p=0.01 and p=0.07, respectively).


CONCLUSIONS
The concentrations of total and mature TGF-beta(2) were higher in cases of rhegmatogenous retinal detachment associated with subretinal strand formation compared to those without subretinal strand formation.
Hirase
Kumiko
K
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Sugiyama
Tetsuya
T
Ikeda
Tsunehiko
T
Sotozono
Chie
C
Yasuhara
Toru
T
Koizumi
Kan
K
Kinoshita
Shigeru
S
D001826:Body Fluids / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053781:Transforming Growth Factor beta2
C509041:TGFB2 protein, human; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2