title: Radical hydroxyalkylation of C-H bond adjacent to nitrogen of tertiary amides, ureas, and amines.
abstract: Tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the Et3B/air conditions, thereby providing a unique and simple means for the radical sp3 C-H transformation of nitrogen-containing molecules.
authors.affiliation: Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan. takey@my-pharm.ac.jp
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yoshimitsu
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Arano
authors.forename: Hiroto
authors.initials: H
authors.lastname: Nagaoka
mesh_terms: D000478:Alkylation; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D014510:Urease / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D000588:Amines; D005609:Free Radicals; D014510:Urease; D009584:Nitrogen