title: Epigenetic silencing in embryogenesis.
abstract: Transcription profiling of early embryos emphasizes that differential gene expression is a fundamental control mechanism of development. Precise regulatory mechanisms operate on a background of epigenetic changes in chromatin composition, modification, and architecture that are integral for the development of a pluripotent embryo into an adult.
authors.affiliation: Human Genome Unit, Medical Research Council, Western General Hospital, Crewe Road, Edinburgh EH4 9XU, UK. r.meehan@hgu.mrc.ac.uk
authors.forename: Richard R
authors.initials: RR
authors.lastname: Meehan
authors.forename: Donncha S
authors.initials: DS
authors.lastname: Dunican
authors.forename: Alexey
authors.initials: A
authors.lastname: Ruzov
authors.forename: Sari
authors.initials: S
authors.lastname: Pennings
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000502:physiology*; D020868:Gene Silencing / Q000502:physiology*; D006801:Humans