title: Kinetic resolutions of azomethine imines via copper-catalyzed [3 + 2] cycloadditions.
abstract: An effective method has been developed for the kinetic resolution of racemic azomethine imines via [3 + 2] cycloadditions with alkynes catalyzed by a chiral copper complex. Efficient kinetic resolution is observed for a variety of N1 and C5 substituents on the dipole, thereby furnishing a wide array of useful enantioenriched azomethine imines, which can readily be transformed into monocyclic and bicyclic pyrazolidinones.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Andrés
authors.initials: A
authors.lastname: Suárez
authors.forename: C Wade
authors.initials: CW
authors.lastname: Downey
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Fu