title: Identification and characterization of a novel member of murine semaphorin family.
abstract: The semaphorin gene family contains a large number of secreted type or transmembrane type proteins, and some of them function as the repulsive and attractive cues of axon guidance during development. Here we report a novel member of murine class 3 semaphorin genes, semaphorin 3G (Sema3G), mapped on chromosome 14. In adulthood, Sema3G is mainly expressed in the lung and kidney, and a little in the brain. Interestingly, in the adult rodent brain Sema3G is expressed only in the granular layer of the cerebellum, as determined by Northern blot and in situ hybridization analyses. We also found that Sema3G binds Neuropilin-2, but not Neuropilin-1, and induces the repulsion of sympathetic axons, but not dorsal root ganglion axons, indicating that Sema3G utilizes Neuropilin-2 as a receptor to repel specific types of axons.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. taniguti@m.u-tokyo.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Masuda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fukaya
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kataoka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Mishina
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yaginuma
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takao
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002642:Chick Embryo; D003001:Cloning, Molecular; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D039942:Neuropilin-1 / Q000378:metabolism; D039943:Neuropilin-2 / Q000378:metabolism; D040121:Semaphorin-3A / Q000378:metabolism; D039961:Semaphorins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013045:Species Specificity
chemical_list: D039943:Neuropilin-2; C488217:Sema3a protein, mouse; D040121:Semaphorin-3A; D039961:Semaphorins; C505763:semaphorin 3G, mouse; D039942:Neuropilin-1