Sequencing of aromatase inhibitors.
Since the development of the third-generation aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, these agents have been the subject of intensive research to determine their optimal use in advanced breast cancer. Not only have they replaced progestins in second-line therapy and challenged the role of tamoxifen in first-line, but there is also evidence for a lack of cross-resistance between the steroidal and nonsteroidal AIs, meaning that they may be used in sequence to obtain prolonged clinical benefit. Many questions remain, however, as to the best sequence of the two types of AIs and of the other available agents, including tamoxifen and fulvestrant, in different patient groups.
Bertelli
G
G
South West Wales Cancer Institute, Sketty, Swansea SA2 8QA, UK. gianfilippo.bertelli@swansea-tr.wales.nhs.uk
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D047072:Aromatase Inhibitors / Q000008:administration & dosage* / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D013256:Steroids / Q000008:administration & dosage
D047072:Aromatase Inhibitors; D013256:Steroids