Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells.
The development of the calcium signalling field, from its early beginnings some 40 years ago to the present, is described. Calcium signalling in exocrine gland acinar cells and the effects of neurotransmitter- or hormone-elicited rises in the cytosolic calcium ion concentration on ion channel gating are reviewed. The highly polarized arrangement of the organelle systems in living acinar cells is described as well as its importance for the physiologically relevant local and polarized calcium signalling events.
Petersen
Ole H
OH
MRC Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK. o.h.petersen@liv.ac.uk
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002413:Cations, Divalent / Q000378:metabolism; D004594:Electrophysiology / Q000266:history*; D005088:Exocrine Glands / Q000166:cytology / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007473:Ion Channels / Q000266:history*; D018408:Patch-Clamp Techniques / Q000266:history*
D002413:Cations, Divalent; D007473:Ion Channels