title: Biosynthetic (14)C-labelling of xanthohumol in hop cones.
abstract: Xanthohumol (Xn) has well-established chemopreventive potential in vitro. In order to carry out in vivo bioavailability and tissue distribution studies,( 14)C-labelled Xn was produced by biolabelling. Supplying hop sprouts with 5 mCi [U-(14)C]glucose led to incorporation of (14)C into Xn. Delivering the radioactive precursor at once resulted in Xn with a specific activity of 318 microCi.mmol(-1); if however the amount was supplied in aliquots over 4 days a specific activity of only 53.1 microCi.mmol(-1) Xn was obtained.
authors.affiliation: Pharmakognosie und Analytische Phytochemie, Universität des Saarlandes, Saarbrücken, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Berwanger
authors.forename: Norbert
authors.initials: N
authors.lastname: Frank
authors.forename: Jutta
authors.initials: J
authors.lastname: Knauft
authors.forename: Hans
authors.initials: H
authors.lastname: Becker
mesh_terms: D002250:Carbon Radioisotopes; D005419:Flavonoids; D005947:Glucose / Q000378:metabolism; D027582:Humulus / Q000378:metabolism*; D007553:Isotope Labeling / Q000379:methods*; D011427:Propiophenones / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D027343:Rhizome / Q000378:metabolism
chemical_list: D002250:Carbon Radioisotopes; D005419:Flavonoids; D011427:Propiophenones; D005947:Glucose; C104536:xanthohumol