Virology, pathology, and clinical manifestations of West Nile virus disease.
West Nile virus (WNV) causes epidemics of febrile illness, meningitis, encephalitis, and flaccid paralysis. Since it was first detected in New York City in 1999, and through 2004, >16,000 WNV disease cases have been reported in the United States. Over the past 5 years, research on WNV disease has expanded rapidly. This review highlights new information regarding the virology, clinical manifestations, and pathology of WNV disease, which will provide a new platform for further research into diagnosis, treatment, and possible prevention of WNV through vaccination.
Hayes
Edward B
EB
Centers for Disease Control and Prevention, Fort Collins, Colorado 80526, USA. ebh2@cdc.gov
Sejvar
James J
JJ
Zaki
Sherif R
SR
Lanciotti
Robert S
RS
Bode
Amy V
AV
Campbell
Grant L
GL
D000998:Antiviral Agents / Q000627:therapeutic use; D006801:Humans; D014765:Viral Vaccines / Q000627:therapeutic use; D014901:West Nile Fever / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000821:virology*; D014902:West Nile virus / Q000254:growth & development*
D000998:Antiviral Agents; D014765:Viral Vaccines