Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.
The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease.
Yoo
Jane
J
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101, USA.
Omori
Miyuki
M
Gyarmati
Dora
D
Zhou
Baohua
B
Aye
Theingi
T
Brewer
Avery
A
Comeau
Michael R
MR
Campbell
Daniel J
DJ
Ziegler
Steven F
SF
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D003876:Dermatitis, Atopic / Q000097:blood / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015603:Keratinocytes / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D018418:Th2 Cells / Q000378:metabolism* / Q000473:pathology; D019076:Transgenes / Q000235:genetics; D000094632:Thymic Stromal Lymphopoietin
D016207:Cytokines; D007073:Immunoglobulin E; D000094632:Thymic Stromal Lymphopoietin