Molarless-induced changes of spines in hippocampal region of SAMP8 mice.
We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses.
Kubo
Kin-Ya
KY
Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan. kubo@dent.asahi-u.ac.jp
Iwaku
Fumihiko
F
Watanabe
Kazuko
K
Fujita
Masafumi
M
Onozuka
Minoru
M
D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D049229:Dendritic Spines / Q000502:physiology* / Q000648:ultrastructure; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008963:Molar / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure; D011930:Reaction Time; D016622:Silver Staining / Q000379:methods; D013997:Time Factors