title: Rapid 1H[13C]-resolved diffusion and spin-relaxation measurements by NMR spectroscopy.
abstract: Hadamard-encoded heteronuclear-resolved NMR diffusion and relaxation measurements allow overlapping signal decays to be resolved with substantially shorter measuring times than are generally associated with 2D heteronuclear cross-correlation experiments. Overall measuring time requirements can be reduced by approximately an order of magnitude, compared to typical 2D heteronuclear single-quantum correlation-resolved diffusion or relaxation measurements. Specifically, in cases where chemical shift correlation information provides enhanced spectral resolution, the use of Hadamard encoding can be used to overcome uniqueness challenges that are associated with the analysis of concurrent dynamic processes and the extraction of time constants from overlapping exponential signal decays. This leads to substantially improved resolution of similar time constants than can be achieved solely through the use of post-acquisition processing techniques. In the ideal case of complete spectral separation of the signal decays, the usual constraint that time constants must be sufficiently different to resolve by exponential analysis can be circumvented entirely. Hadamard-based pulse sequences have been used to determine 1H[13C]-resolved diffusion coefficients and spin-relaxation time constants for the chemically similar components of an aqueous solution of ethanol, glycerol, and poly(ethylene glycol), and a dye-containing block-copolymer solution, which exhibit significant spectral overlap in their 1H NMR spectra.
authors.affiliation: Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Steinbeck
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Chmelka
mesh_terms: D002247:Carbon Isotopes; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards; D011522:Protons; D012015:Reference Standards
chemical_list: D002247:Carbon Isotopes; D011522:Protons