title: Tools and strategies for physiological genomics: the Rat Genome Database.
abstract: The broad goal of physiological genomics research is to link genes to their functions using appropriate experimental and computational techniques. Modern genomics experiments enable the generation of vast quantities of data, and interpretation of this data requires the integration of information derived from many diverse sources. Computational biology and bioinformatics offer the ability to manage and channel this information torrent. The Rat Genome Database (RGD; http://rgd.mcw.edu) has developed computational tools and strategies specifically supporting the goal of linking genes to their functional roles in rat and, using comparative genomics, to human and mouse. We present an overview of the database with a focus on these unique computational tools and describe strategies for the use of these resources in the area of physiological genomics.
authors.affiliation: Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Simon N
authors.initials: SN
authors.lastname: Twigger
authors.forename: Dean
authors.initials: D
authors.lastname: Pasko
authors.forename: Jeff
authors.initials: J
authors.lastname: Nie
authors.forename: Mary
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authors.lastname: Shimoyama
authors.forename: Susan
authors.initials: S
authors.lastname: Bromberg
authors.forename: Dan
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authors.lastname: Campbell
authors.forename: Jiali
authors.initials: J
authors.lastname: Chen
authors.forename: Norberto
authors.initials: N
authors.lastname: dela Cruz
authors.forename: Chunyu
authors.initials: C
authors.lastname: Fan
authors.forename: Cindy
authors.initials: C
authors.lastname: Foote
authors.forename: Glenn
authors.initials: G
authors.lastname: Harris
authors.forename: Brian
authors.initials: B
authors.lastname: Hickmann
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ji
authors.forename: Weihong
authors.initials: W
authors.lastname: Jin
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.forename: Jedidiah
authors.initials: J
authors.lastname: Mathis
authors.forename: Nataliya
authors.initials: N
authors.lastname: Nenasheva
authors.forename: Rajni
authors.initials: R
authors.lastname: Nigam
authors.forename: Victoria
authors.initials: V
authors.lastname: Petri
authors.forename: Dorothy
authors.initials: D
authors.lastname: Reilly
authors.forename: Victor
authors.initials: V
authors.lastname: Ruotti
authors.forename: Eric
authors.initials: E
authors.lastname: Schauberger
authors.forename: Kathy
authors.initials: K
authors.lastname: Seiler
authors.forename: Ronit
authors.initials: R
authors.lastname: Slyper
authors.forename: Jennifer
authors.initials: J
authors.lastname: Smith
authors.forename: Weiye
authors.initials: W
authors.lastname: Wang
authors.forename: Wenhua
authors.initials: W
authors.lastname: Wu
authors.forename: Lan
authors.initials: L
authors.lastname: Zhao
authors.forename: Angela
authors.initials: A
authors.lastname: Zuniga-Meyer
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Tonellato
authors.forename: Anne E
authors.initials: AE
authors.lastname: Kwitek
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Jacob
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D016678:Genome / Q000235:genetics*; D023281:Genomics / Q000379:methods*; D051381:Rats / Q000235:genetics* / Q000502:physiology*