International Equine Gene Mapping Workshop Report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources.
A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7%) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are < or = 5 cM and only 3% > or = 20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.
Penedo
M C T
MC
School of Veterinary Medicine, University of California, Davis, CA, USA. mctorrespenedo@ucdavis.edu
Millon
L V
LV
Bernoco
D
D
Bailey
E
E
Binns
M
M
Cholewinski
G
G
Ellis
N
N
Flynn
J
J
Gralak
B
B
Guthrie
A
A
Hasegawa
T
T
Lindgren
G
G
Lyons
L A
LA
Røed
K H
KH
Swinburne
J E
JE
Tozaki
T
T
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D005819:Genetic Markers; D006736:Horses / Q000235:genetics*; D016013:Likelihood Functions; D014960:X Chromosome
D005819:Genetic Markers