[Progress in type III secretion system].
Many Gram-negative bacteria use the type III secretion system (TTSS) to inject toxin proteins into host cells, then cause the plague disease, typhoid fever, diarrhea disease etc. Chaperone proteins is one of four components of MTSS and play an important role in helping the secretion of toxin proteins. Although these proteins had been found for almost ten years, the detailed function of chaperones is enigmatic. In this review, a brief introduction is given about the progress of classification, function of chaperones and characteristics of the interactions between chaperones and substrates.
Wang
Li
L
State Key Laboratory of Medical Microbiology and Biosafety, Institute of Biotechnology, Academy of Military Sciences, Beijing 100071, China. wangl@bioinf.bmi.ac.cn
Wang
Yu-Ming
YM
Yue
Jun-Jie
JJ
Liang
Long
L
Huang
Pei-Tang
PT
D006090:Gram-Negative Bacteria / Q000378:metabolism*; D018832:Molecular Chaperones / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D017510:Protein Folding
D018832:Molecular Chaperones