title: Evolving management strategies for heparin-induced thrombocytopenia.
abstract: New treatment strategies based on the availability of alternative anticoagulants have improved outcomes for patients with heparin-induced thrombocytopenia (HIT). Patients with HIT are at an extreme risk of thrombosis even after the discontinuation of heparin. Maintaining a high degree of awareness and instituting alternative anticoagulation immediately on suspicion of HIT are the two keys to preventing death, limb amputation, and other complications such as pulmonary embolism, myocardial infarction, or stroke; stopping heparin alone is inadequate. Warfarin should not be used early or unopposed with HIT, and when appropriate, transition to warfarin must be done cautiously to avoid venous limb gangrene or central skin necrosis. The direct thrombin inhibitors (DTIs) lepirudin and argatroban are approved by the US Food and Drug Administration for treating HIT and both are effective for improving patient outcomes. Because of its favorable pharmacologic characteristics, the DTI bivalirudin has been successfully employed in HIT, particularly in patients with multiorgan failure.
authors.affiliation: Baylor College of Medicine, Texas Medical Center, Houston, TX, USA. lrice@bcm.tmc.edu
authors.forename: Lawrence
authors.initials: L
authors.lastname: Rice
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001120:Arginine / Q000031:analogs & derivatives; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D010875:Pipecolic Acids / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011655:Pulmonary Embolism / Q000209:etiology / Q000517:prevention & control; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010875:Pipecolic Acids; D010975:Platelet Aggregation Inhibitors; D013449:Sulfonamides; D014859:Warfarin; D006493:Heparin; D001120:Arginine; C031942:argatroban