[Activation of psoriasis in patients undergoing treatment with interferon-beta].
Psoriasis is a chronic, inflammatory skin disorder that is induced and aggravated by a number of endogenous and exogenous factors. Traditionally lithium, beta blockers, NSAIDs, ACE inhibitors and antimalarials have been associated with psoriasis, but interferon can also be a triggering factor. We present two patients with multiple sclerosis who suffered from activation of psoriasis in relation to interferon-beta treatment. In one of the patients, psoriasiform injection site lesions persisted six years after termination of the interferon treatment.
Navne
Johan Emdal
JE
Odense Universitetshospital, Dermato-venerologisk Afdeling I, og Laegemiddelinformationscentralen, Afdeling KKA.
Hedegaard
Ulla
U
Bygum
Anette
A
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000473:pathology; D011565:Psoriasis / Q000139:chemically induced* / Q000473:pathology
D000276:Adjuvants, Immunologic; D016899:Interferon-beta