title: Adiponectin serum concentrations in men with coronary artery disease: the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study.
abstract: BACKGROUND
  Adiponectin, the most abundant adipocytokine of adipose tissue cells, has recently been found to be decreased in coronary artery disease (CAD). Data concerning adiponectin in different stages of CAD are rare, and it was not investigated if adiponectin levels are influenced by the severity of angina pectoris.
  
  
  METHODS
  Thus, we measured adiponectin serum levels by means of ELISA in 1626 male probands, including 273 control subjects, 367 subjects with silent CAD, 608 patients with stable, and 378 patients with unstable angina.
  
  
  RESULTS
  As compared to controls (8.56; 5.85 to 12.85 microg/ml) and subjects with silent CAD (8.60; 5.99 to 12.64 microg/ml), adiponectin was significantly decreased in patients with stable (7.22; 5.06 to 10.41 microg/ml; p < 0.001 for both) and unstable angina (6.72; 4.08 to 10.08 microg/ml; p < 0.001 for both). By a logistic regression analysis, low adiponectin levels were identified as a significant independent predictor for stable and unstable angina (p < 0.001 for both). No significant differences of adiponectin were observed, neither between the stable and unstable angina group, nor between any classes of angina according to the Canadian Cardiovascular Society (CCS) Angina Score for stable angina.
  
  
  CONCLUSIONS
  These results suggest, that decreased adiponectin levels are indicative for symptomatic CAD, but are not further influenced by the progression of this disease.
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University, Graz, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Pilz
authors.forename: Winfried
authors.initials: W
authors.lastname: Maerz
authors.forename: Gisela
authors.initials: G
authors.lastname: Weihrauch
authors.forename: Karine
authors.initials: K
authors.lastname: Sargsyan
authors.forename: Gunter
authors.initials: G
authors.lastname: Almer
authors.forename: Markus
authors.initials: M
authors.lastname: Nauck
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Boehm
authors.forename: Bernhard R
authors.initials: BR
authors.lastname: Winkelmann
authors.forename: Harald
authors.initials: H
authors.lastname: Mangge
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol