title: Comparison of clinical efficacy of Newfactan versus Surfacten for the treatment of respiratory distress syndrome in the newborn infants.
abstract: Newfactan is a domestically developed, bovine lung-derived, semi-synthetic surfactant. The aim of this study was to compare the clinical efficacy of Newfactan with that of Surfacten in the treatment of respiratory distress syndrome (RDS). Newfactan or Surfacten was randomly allocated to 492 newborn infants who were diagnosed as RDS and required surfactant instillation in four participating hospitals. The comparisons were made individually in two subsets of infants by birth weight (<1,500 g group [n=253] and > or =1,500 g group [n=239]). Short-term responses to surfactant and acute complications, such as the total doses of surfactant instilled, response type, extubation rate, ventilator settings, changes in respiratory parameters, air leak, patent ductus arteriosus, pulmonary hemorrhage, and intraventricular hemorrhage, and mortality during the 96 hr after surfactant instillation were measured. Long-term outcome and complications, such as total duration of intubation, bronchopulmonary dysplasia and periventricular leukomalacia, and ultimate mortality were measured. There were no significant differences in demographic and perinatal variables, shortterm responses to surfactant and acute complications, and long-term outcome and complications between Newfactan and Surfacten in both birth weight groups. We concluded that Newfactan was comparable to Surfacten in the clinical efficacy in the treatment of RDS in both birth weight groups.
authors.affiliation: Department of Pediatrics, Samsung Seoul Hospital, Samsung Cheil Hospital, Korea.
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Choi
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Hwang
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Yoo
authors.forename: Kyung Ah
authors.initials: KA
authors.lastname: Kim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Koh
authors.forename: Yeon Kyung
authors.initials: YK
authors.lastname: Lee
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Shim
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Lee
authors.forename: Wook
authors.initials: W
authors.lastname: Chang
authors.forename: Sung Shin
authors.initials: SS
authors.lastname: Kim
authors.forename: Yun Sil
authors.initials: YS
authors.lastname: Chang
authors.forename: Won Soon
authors.initials: WS
authors.lastname: Park
authors.forename: Son Moon
authors.initials: SM
authors.lastname: Shin
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011663:Pulmonary Surfactants