title: Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402.
abstract: Ganoderic acid (GA), produced by submerged culture of Ganoderma lucidum, at 500 microg/ml, caused nearly a 70% inhibition of the growth of human hepatoma cell line BEL7402 but not of a normal human liver cell line L02. Flow cytometry analyses showed that GA blocked the BEL7402 cell cycle at the transition from G(1 )to S phase.
authors.affiliation: School of Life & Environmental Science, Wenzhou University, Wenzhou, People's Republic of China. yanghl999@yahoo.com
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Yang
mesh_terms: D018533:Biomass; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000503:physiopathology; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000503:physiopathology; D025282:Mycelium / Q000254:growth & development / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism / Q000494:pharmacology; D020940:Reishi / Q000254:growth & development / Q000378:metabolism*; D013997:Time Factors; D014315:Triterpenes / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D011134:Polysaccharides; D014315:Triterpenes; C468428:ganoderic acid LM2