title: [Effect of induction chemotherapy followed by surgery for bulky N2, T4 non-small cell lung cancer].
abstract: It is controversial that the effect of induction chemotherapy for bulky N2, T4 non-small cell lung cancer. We examined a retrospective study to assess this issue. Ten patients with bulky N2, T4 disease were given bronchial arterial infusion consisting of cisplatin (60 mg/m2) and docetaxel hydrate (60 mg/m2) intravenously, followed by standardized surgical resection (group A). Thirty patients had pathological N2, T4 disease after surgery (group B). Pathologically downstaging was seen in 6 patients in group A. The overall long-term survival at 1-, 2-year were 87.5, 87.5% in group A. The long-term survival at 1-, 2-, and 5-year were 78.9, 49.8, 43.6% in group B. There was no statistically significant difference in survival between both groups (p = 0.3015). The effect of induction chemotherapy for bulky N2, T4 non-small cell lung cancer was not demonstrated in our data. We suggest that our induction chemotherapy in group A was effective on T4 disease. A prospective study is needed to investigate our regimen.
authors.affiliation: Department of Thoracic Surgery, Toyooka Hospital, Toyooka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Maze
authors.forename: H
authors.initials: H
authors.lastname: Tenpaku
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods*; D011446:Prospective Studies; D016019:Survival Analysis; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin