Cell migration during gastrulation.
As the gateway to shaping the body plan, gastrulation is an important problem in developmental biology, and recent advances in cell biology have overcome some of the limitations of past approaches to learning how genes control reshaping of embryonic tissues. The use of fluorescent tracer dyes and live cell imaging methods to evaluate at the cellular level the results of genetic and molecular manipulations has advanced our understanding of the cell motility and contact behavior underlying tissue remodeling during gastrulation.
Keller
Ray
R
Department of Biology and Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, Virginia 22904, USA. rek3k@virginia.edu
D000818:Animals; D019521:Body Patterning / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology; D004707:Endoderm / Q000502:physiology; D005775:Gastrula / Q000166:cytology / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000502:physiology; D008954:Models, Biological; D009024:Morphogenesis; D015398:Signal Transduction / Q000502:physiology