title: Rapeseed oil, olive oil, plant sterols, and cholesterol metabolism: an ileostomy study.
abstract: OBJECTIVE
  To study whether olive oil and rapeseed oil have different effects on cholesterol metabolism.
  
  
  METHODS
  Short-term experimental study, with controlled diets.
  
  
  METHODS
  Outpatients at a metabolic-ward kitchen.
  
  
  METHODS
  A total of nine volunteers with conventional ileostomies.
  
  
  METHODS
  Two 3-day diet periods; controlled diet including 75 g of rapeseed oil or olive oil.
  
  
  METHODS
  Cholesterol absorption, ileal excretion of cholesterol, and bile acids. Serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank sum test.
  
  
  RESULTS
  Rapeseed oil diet contained 326 mg more plant sterols than the olive oil diet. Rapeseed oil tended to decrease cholesterol absorption by 11% (P = 0.050), and increased excretion of cholesterol, bile acids, and their sum as sterols by 9% (P = 0.021), 32% (P = 0.038), and 51% (P = 0.011) compared to olive oil. A serum marker for bile acid synthesis (7alpha-hydroxy-4-cholesten-3-one) increased by 28% (P = 0.038) within 10 h of consumption, and serum cholesterol levels decreased by 7% (P = 0.024), whereas a serum marker for cholesterol synthesis (lathosterol) as well as serum levels of plant sterols remained unchanged.
  
  
  CONCLUSIONS
  Rapeseed oil and olive oil have different effects on cholesterol metabolism. Rapeseed oil, tends to decrease cholesterol absorption, increases excretion of cholesterol and bile acids, increases serum marker of bile acid synthesis, and decreases serum levels of cholesterol compared to olive oil. This could in part be explained by different concentrations of natural plant sterols.
  
  
  BACKGROUND
  Supported by the Göteborg Medical Society, the Swedish Medical Society, the Swedish Board for Agricultural Research (SJFR) grant 50.0444/98 and by University of Göteborg.
authors.affiliation: Department of Clinical Nutrition, University of Göteborg, Sahlgrenska University Hospital, Sweden. Lasse.Ellegard@sahlgrenska.se
authors.forename: L
authors.initials: L
authors.lastname: Ellegård
authors.forename: H
authors.initials: H
authors.lastname: Andersson
authors.forename: I
authors.initials: I
authors.lastname: Bosaeus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology; D004043:Dietary Fiber / Q000008:administration & dosage / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated; D005260:Female; D006801:Humans; D007081:Ileostomy; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010840:Phytosterols / Q000378:metabolism*; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000074262:Rapeseed Oil
chemical_list: D001647:Bile Acids and Salts; D004041:Dietary Fats; D004043:Dietary Fiber; D005229:Fatty Acids, Monounsaturated; D000069463:Olive Oil; D010840:Phytosterols; D010938:Plant Oils; D000074262:Rapeseed Oil; D002784:Cholesterol