The mimetics of antiadhesive peptides as the inhibitors of Mycobacterium kansasii phagocytosis.
The alpha-guanidino acids derived of 15 proteinaceous amino acids, omega-guanidino acids with gradually increased hydrocarbon chains, and amidinated dipeptides, were tested as the mimetics of antiadhesive peptides in Mycobacteria phagocytosis inhibition. The crystal structure of omega-guanidino acids used was determined by X-ray structural analysis. It follows from our experiments that the proper distance between guanidine and carboxyl groups of effector molecules is of decisive importance for their inhibitory activity.
Siemion
Ignacy Z
IZ
Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wroclaw, Poland.
Gawłowska
Monika
M
Slepokura
Katarzyna
K
Biernat
Monika
M
Wieczorek
Zbigniew
Z
D000578:Amidines / Q000737:chemistry / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D019791:Guanidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000502:physiology; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D019909:Mycobacterium kansasii; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*
D000578:Amidines; D000596:Amino Acids; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; C004946:glycocyamine; D019791:Guanidine; D005998:Glycine