[Posttraumatic stress disorder (PTSD)].
The diagnosis of posttraumatic stress disorder (PTSD) has been introduced in 1980. The diagnosis, as construct raises several political, moral, legal, and compensation issues. PTSD is considered as a multisystemic dysregulation, involving the hypothalamic- pituitary - adrenal axis, adrenergic hypersensibility, and serotonergic dysfunction. The prevalence of PTSD is 1-9% in the general population, but substantially higher among victims of traumatic events: 19-70%. Placebo controlled studies provide a body of evidence concerning efficacy of selective serotonin reuptake inhibitors in the treatment of PTSD both in the acute and maintenance treatments. Studies with balanced male-female ratio suggest no gender-related differences in the clinical response, furthermore both civilians and veterans improved significantly for selective serotonin reuptake inhibitor treatment.
Martényi
Ferenc
F
Mens Sana Bt., Budapest. ferenc_martenyi@yahoo.com
D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D002395:Catecholamines / Q000378:metabolism; D015897:Comorbidity; D018849:Controlled Clinical Trials as Topic; D019548:Crime Victims / Q000523:psychology; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D015994:Incidence; D008016:Life Change Events; D008297:Male; D017374:Paroxetine / Q000627:therapeutic use; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D015995:Prevalence; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D016896:Treatment Outcome; D014729:Veterans Disability Claims; D047829:Vietnam Conflict; D047828:World War I; D047789:World War II
D018687:Antidepressive Agents, Second-Generation; D002395:Catecholamines; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline