title: A polymorphism of the plasminogen activator inhibitor-1 gene promoter and the polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the association of a common 5G/4G polymorphism of the plasminogen activator inhibitor-1 gene (PAI1) with occurrence and clinical characteristics of the polycystic ovary syndrome (PCOS).
  
  
  METHODS
  In a case-control study, we evaluated a series of 106 Caucasian women with PCOS and 102 healthy controls. Women completed a detailed questionnaire and underwent a peripheral venous puncture, ultrasonography, and a standardized oral glucose tolerance test (OGTT). The PAI1 gene promoter polymorphism was evaluated using PCR.
  
  
  RESULTS
  Allele and genotype frequencies were not significantly different among women with PCOS and controls (P=0.3 and 0.6, respectively). In women with PCOS, presence of the 5G/4G polymorphism of PAI1 was not associated with changes in serum hormone levels or with clinical characteristics.
  
  
  CONCLUSIONS
  The 5G/4G polymorphism of the PAI1 promoter is not associated with occurrence and phenotype of the PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Infertility Treatment, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. katharina.walch@meduniwien.ac.at
authors.forename: Katharina
authors.initials: K
authors.lastname: Walch
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Huber
authors.forename: Friedrich
authors.initials: F
authors.lastname: Nagele
authors.forename: Andrea
authors.initials: A
authors.lastname: Kolbus
authors.forename: Lukas A
authors.initials: LA
authors.lastname: Hefler
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D017395:Plasminogen Activator Inhibitor 1