Downregulation of VLA-4 on T cells as a marker of long term treatment response to interferon beta-1a in MS.
We determined longitudinally the expression of a panel of adhesion molecules on T cells and soluble ICAM-1, VCAM-1 and tumor necrosis factor apoptosis inducing ligand (TRAIL) in serum during first year of the PRISMS Study with IFNbeta1a in MS. Clinical data and quantitative MRI data were available for 4 years. VLA-4 was down-regulated on T cells and VCAM-1 was up-regulated in serum during the first 3 to 6 months of therapy in patients with favorable long-term treatment response (EDSS progression </=1.0 in 4 years). Short disease duration and low EDSS were clinical pre-treatment characteristics related to good long-term response to therapy.
Soilu-Hänninen
Merja
M
Department of Neurology, University of Turku, Kiinamyllynkatu 4-8 PL52, FIN-20521 Turku, Finland. mersoi@utu.fi
Laaksonen
Mikko
M
Hänninen
Arno
A
Erälinna
Juha-Pekka
JP
Panelius
Martin
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D051017:Apoptosis Regulatory Proteins / Q000097:blood; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation / Q000187:drug effects*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000188:drug therapy*; D013601:T-Lymphocytes / Q000187:drug effects*; D053221:TNF-Related Apoptosis-Inducing Ligand; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha
D000276:Adjuvants, Immunologic; D051017:Apoptosis Regulatory Proteins; D039041:Integrin alpha4beta1; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D016899:Interferon-beta; D000068556:Interferon beta-1a