title: The first synthesis of chiral PNA monomer-cyclen conjugates.
abstract: A synthetic route to novel chiral PNA monomer-cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil-PNA monomer-cyclen conjugates can rapidly bind Zn2+ in aqueous solution, and the structure of the Zn(II) complex was confirmed facilely by HRMS spectra, 1H NMR spectra and elemental analysis.
authors.affiliation: Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu 610064, P. R. China.
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Ma
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Zhang
authors.forename: Shan-Yong
authors.initials: SY
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Jing-Song
authors.initials: JS
authors.lastname: You
authors.forename: Chuan-Qin
authors.initials: CQ
authors.lastname: Xia
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D002942:Circular Dichroism; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014498:Uracil / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000080027:Cyclams; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D020135:Peptide Nucleic Acids; D014498:Uracil; C038072:cyclen; D015032:Zinc