[Effects of early weaning on the blood glucose, blood lipid and hormone of rat fed a high fat diet].
OBJECTIVE
To observe the effects of early weaning on the blood glucose, blood lipid and hormone of rat fed a high fat diet.


METHODS
Male Wistar rats were randomly divided into two groups after born 17 days according to body weight. One group was early weaned in the 17th day, the other was breastfed until the 24th day. After 4 weeks fed with basic diet, 12 rats were randomly selected from each group and were sacrificed. The other rats of each group were further randomly divided into 2 groups according to body weight. One group was fed a high fat diet, the other was fed the basic diet. The rats were sacrificed respectively at the end of the experiment. The blood glucose, serum lipids, and hormones were measured.


RESULTS
Compared with the normal weaning rats, the weight and fat pad of early weaning rats significantly increased and the level of blood glucose, serum lipids, insulin, leptin also increased significantly (P < 0.05), the level of HDL, FT3 decreased (P < 0.05).


CONCLUSIONS
The tendency of obesity in early weaning rats were more obvious than normal weaning rats after fed a high fat diet.
Wang
Xiao-Chun
XC
School of Public Health, Harbin Medical University, Harbin 150086, China.
Sun
Chang-Hao
CH
Zhang
Xiao-Hong
XH
Zhao
Li-Jun
LJ
Zheng
Jing
J
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005247:Feeding Behavior / Q000502:physiology; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014886:Weaning
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D020738:Leptin; D008055:Lipids