title: Injury reactive myelin/oligodendrocyte-derived axon growth inhibition in the adult mammalian central nervous system.
abstract: Myelin inhibition is considered a constitutive, static, repulsive barrier not reactive to a central nervous system (CNS) lesion. However, recent evidence underlines the existence of considerable add-on axon growth inhibition upon CNS injury. This postlesional, reactive myelin/oligodendrocyte-derived inhibition will require the development of novel screening approaches and therapeutic reagents to promote axonal regeneration.
authors.affiliation: CNRS UMR 7102, Equipe Développement Neuronal, Université Pierre et Marie Curie (Paris 6), Batiment B, Case 12, 9 Quai Saint Bernard, 75005 Paris, France.
authors.forename: Jan M
authors.initials: JM
authors.lastname: Schwab
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bernard
authors.forename: Caroline
authors.initials: C
authors.lastname: Moreau-Fauvarque
authors.forename: Alain
authors.initials: A
authors.lastname: Chédotal
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000473:pathology* / Q000503:physiopathology*; D005786:Gene Expression Regulation; D008959:Models, Neurological; D009185:Myelin Proteins / Q000378:metabolism*; D018992:Myelin-Associated Glycoprotein; D009416:Nerve Regeneration; D009836:Oligodendroglia / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein