Frontotemporal dementia with ubiquitinated neuronal inclusions and visuospatial impairment.
Dementia with ubiquitinated neuronal inclusions has been described only with frontotemporal dementia (FTD). The authors report a patient with progressive FTD accompanied by prominent impairments in visuospatial cognitive functions. Pathology was characterized by ubiquitin-positive intranuclear and cytoplasmic neuronal inclusions. Cortical pathology was widespread and posteriorly accentuated but spared the hippocampal dentate gyrus.
Meiner
Z
Z
Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Newman
J P
JP
Rosenman
H
H
Soffer
D
D
Steiner
I
I
D000377:Agnosia / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003704:Dementia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D011597:Psychomotor Performance / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism
D025801:Ubiquitin