title: Clinical validation of high-resolution fast spin-echo MR colonography after colon distention with air.
abstract: To evaluate the feasibility of MR colonography (MRC) with air using two-dimensional (2D) T1-weighted fast spin-echo (T1wFSE) in patients scheduled for conventional colonoscopy (CC) after classic bowel preparation, and assess the ability of the technique to detect colonic lesions. The distention was sufficient for diagnosis, and the technique provided adequate delineation of the wall in the majority of segments. Residual fluid obscured the wall in different segments, especially in the ascending and descending colon (supine position) and in the cecum, transverse, and sigmoid colon (prone position). These findings were consistent with CT colonography. MRC visualized three lesions, missed one lesion >10 mm, visualized none of four lesions <5 mm, and yielded one false-positive lesion (5-10 mm). Missed lesions can be due to inconsistency in the slice positions between consecutive breath-holds, which is inherent to the multishot technique. Residual fluid may have obscured the smaller lesions. The shortcomings of the technique are limited coverage and signal drop-off at the borders of the field of view (FOV). Before multishot 2D T1wFSE colonography can become a valid screening method, improved patient preparation and a more practical technique are needed.
authors.affiliation: Department of Radiology, University Hospital Gasthuisberg K.U. Leuven, Leuven, Belgium. didier.bielen@uz.kuleuven.ac.be
authors.forename: Didier J L E
authors.initials: DJ
authors.lastname: Bielen
authors.forename: Hilde T C
authors.initials: HT
authors.lastname: Bosmans
authors.forename: Liesbeth L I
authors.initials: LL
authors.lastname: De Wever
authors.forename: Frederik
authors.initials: F
authors.lastname: Maes
authors.forename: Sabine
authors.initials: S
authors.lastname: Tejpar
authors.forename: Dirk
authors.initials: D
authors.lastname: Vanbeckevoort
authors.forename: Guy J F
authors.initials: GJ
authors.lastname: Marchal
mesh_terms: D000328:Adult; D000368:Aged; D003106:Colon / Q000033:anatomy & histology*; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged