Search for melanoma markers in plasma and serum samples.
Fourteen blood samples from patients with melanoma and eleven blood samples from healthy subjects were analyzed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. The study was focussed on species of low molecular weight, in the range 800-5000 Da, present in plasma and sera. While for healthy subjects plasma samples lead to the production of a higher number of ionic species, for melanoma patients a high number of diagnostic ions, present with high frequency and with quite high relative abundance, are present in particular in serum samples and to a lesser extent also in plasma. Since plasma samples are obtained more easily in comparison to sera, it is possible to suggest that also plasma can be used for these studies.
Seraglia
Roberta
R
CNR, Istituto di Scienze e Tecnologie Molecolari sezione di Padova, Corso Stati Uniti 4, I35127 Padova, Italy.
Vogliardi
Susanna
S
Allegri
Graziella
G
Comai
Stefano
S
Lise
Mario
M
Rossi
Carlo Ricardo
CR
Mocellin
Simone
S
Scalerta
Romano
R
Ragazzi
Eugenio
E
Traldi
Pietro
P
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002138:Calibration; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood*; D008875:Middle Aged; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D014408:Biomarkers, Tumor