title: Paclitaxel eluting stents for the treatment of angiographically non-significant atherosclerotic lesions.
abstract: OBJECTIVE
  To assess the safety and efficacy of the implantation of Paclitaxel Eluting Stents (PES) for de novo, non-flow limiting lesions.
  
  
  RESULTS
  We assessed the 12-month occurrence of major adverse cardiac events (MACE) in 21 patients (4% of the total population treated in a 'real world' registry) with 22 non-significant coronary narrowings treated with PES. The following criteria had to be met: (1) the lesion was de novo; (2) the location was non-ostial, and not a bifurcation lesion; (3) the diameter stenosis by quantitative coronary angiography (QCA) was <50%; (4) there was no visible thrombus and (5) the lesion was not located in an angiographically diffusely diseased segment. Procedural success rate was 100% without any periprocedural myocardial infarction. After a mean follow-up of 407.33+/-53 (range: 344-498) days the overall MACE-free survival was 95.2%. Freedom from target revascularization was 95.2%.
  
  
  CONCLUSIONS
  The result of this non-randomized observational study suggests that the implantation of PES for de novo, non-significant lesions appears most probably safe and effective.
authors.affiliation: Erasmus Medical Center, Thoraxcenter, Rotterdam, Netherlands.
authors.forename: Gastón
authors.initials: G
authors.lastname: Rodriguez-Granillo
authors.forename: Marco
authors.initials: M
authors.lastname: Valgimigli
authors.forename: Andrew T L
authors.initials: AT
authors.lastname: Ong
authors.forename: Jiro
authors.initials: J
authors.lastname: Aoki
authors.forename: Carlos A G
authors.initials: CA
authors.lastname: van Mieghem
authors.forename: Angela
authors.initials: A
authors.lastname: Hoye
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tsuchida
authors.forename: Eugene
authors.initials: E
authors.lastname: McFadden
authors.forename: Pim
authors.initials: P
authors.lastname: de Feyter
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D023903:Coronary Restenosis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D015607:Stents
chemical_list: D017239:Paclitaxel