beta-Catenin regulates the expression of tenascin-C in human colorectal tumors.
Tenascin-C (TN-C) is a component of the extracellular matrix (ECM). It is expressed during development and re-expressed in many types of cancers, where it is involved in the modulation of adhesion and proliferation. TN-C expression is especially high at sites of epithelial mesenchymal transition (EMT), which are found frequently at the invasion front of well-differentiated human colorectal adenocarcinomas. Tumor cells in this compartment are characterized by a strong nuclear expression of the oncogenic transcription factor beta-catenin. Here, we demonstrate that TN-C is a beta-catenin target gene in human colorectal tumors. Thus, by far the most common mutations in colorectal tumors, found in the Wnt-signaling pathway and leading to the stabilizing of beta-catenin, might influence invasion by altering adhesive properties and EMT of tumor cells.
Beiter
Katharina
K
Pathologisch-Anatomisches Institut, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstr. 8-10, D-91054 Erlangen, Germany.
Hiendlmeyer
Elke
E
Brabletz
Thomas
T
Hlubek
Falk
F
Haynl
Angela
A
Knoll
Claudia
C
Kirchner
Thomas
T
Jung
Andreas
A
D000230:Adenocarcinoma; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000502:physiology; D015179:Colorectal Neoplasms; D004847:Epithelial Cells / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008648:Mesoderm / Q000473:pathology; D009361:Neoplasm Invasiveness; D019063:Tenascin / Q000235:genetics*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
D019063:Tenascin; D051176:beta Catenin