Mice deficient in microtubule-associated protein MAP1B show a distinct behavioral phenotype and altered retina function.
We investigated mice deficient for the microtubule-associated protein MAP1B, a cytoskeletal element highly expressed in the developing nervous system, for altered performance in behavior, learning, and memory. Using the multiple T-maze, the open field and the Morris water maze we found that mice homozygous for a deletion of the MAP1B gene demonstrate impaired locomotor activity most likely correlated to a lack of physical endurance in general. In contrast, there were no significant differences in cognitive function and memory retention. In addition, we performed electroretinography and observed a reduction of the a-wave amplitude in response to single flash, white light stimulation. Taken together, these data provide further evidence for an important role of MAP1B in synaptic neurotransmission.
Pangratz-Fuehrer
Susanne
S
Clinic of Internal Medicine and Infectious Diseases, University of Veterinary Medicine, Veterinaerplatz 1, A-1210 Vienna, Austria.
Bubna-Littitz
Hermann
H
Propst
Friedrich
F
Reitsamer
Herbert
H
D000818:Animals; D004596:Electroretinography; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D006720:Homozygote; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008869:Microtubule-Associated Proteins / Q000172:deficiency / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D010775:Photic Stimulation; D010807:Physical Endurance / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology*
D008869:Microtubule-Associated Proteins; C085284:microtubule-associated protein 1B