Tolterodine-induced hyponatraemia.
Management of electrolyte abnormalities is challenging in older people as the sensation of thirst, renal function and hormonal modulators of the milieu interior are often impaired. Furthermore, the complex effects of ageing upon these homeostatic mechanisms are often superimposed upon a background of chronic disease, malnutrition and co-existent medications. Hyponatraemia is one of the commonest electrolyte abnormalities, occurring in approximately 7% of healthy elderly persons. Hyponatraemia may only come to light when some other ailment prompts investigations or hospital admission. Drug-induced hyponatraemia is common in older people and is most commonly associated with diuretics and SSRI/SNRI antidepressants, but has also been reported with a wide range of other drugs. We believe this is the first case report of hyponatraemia due to tolterodine.
Juss
Jatinder K
JK
Department of Medicine for the Elderly, Addenbrooke's Hospital, Cambridge University Hospitals Foundation Trust, Hills Road, Cambridge CB2 2QQ, UK.
Radhamma
Ajish K J
AK
Forsyth
Duncan R
DR
D000368:Aged; D001559:Benzhydryl Compounds / Q000009:adverse effects*; D003408:Cresols / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D018727:Muscarinic Antagonists / Q000009:adverse effects*; D010665:Phenylpropanolamine / Q000009:adverse effects*; D000068737:Tolterodine Tartrate
D001559:Benzhydryl Compounds; D003408:Cresols; D018727:Muscarinic Antagonists; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate