Molecular detection of Cellulosimicrobium cellulans as the etiological agent of a chronic tongue ulcer in a human immunodeficiency virus-positive patient.
Ulcerations appeared on the tongue of a 48-year-old human immunodeficiency virus-positive man. Histological findings of the biopsy specimen and the fact that the patient had resided in Louisiana led us to suspect "American histoplasmosis". A new ulcer appeared while the patient was being treated with itraconazole, and the gene for 16S rRNA of Cellulosimicrobium cellulans was amplified. The lesions healed during treatment with oral penicillin and azithromycin.
Heym
Beate
B
Microbiology Department, Hôpital Ambroise Paré, Boulogne, France. beate.heym@apr.ap-hop-paris.fr
Gehanno
Pierre
P
Friocourt
Véronique
V
Bougnoux
Marie-Elisabeth
ME
Le Moal
Michèle
M
Husson
Corinne
C
Leibowitch
Jacques
J
Nicolas-Chanoine
Marie-Hélène
MH
D000192:Actinomycetales / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D002908:Chronic Disease; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D014060:Tongue Diseases / Q000209:etiology* / Q000382:microbiology; D014456:Ulcer / Q000209:etiology* / Q000382:microbiology
D012336:RNA, Ribosomal, 16S