Bidirectional modulation of hippocampal long-term potentiation under stress and no-stress conditions in basolateral amygdala-lesioned and intact rats.
Hippocampal long-term potentiation (LTP) is widely considered as a cellular model for learning and memory formation. We have shown previously that protein synthesis-independent, early dentate gyrus (DG) LTP, lasting approximately 4-5 h, can be transformed into a late-LTP with a duration of > or = 24 h by a brief acute swim stress experience (high-stress condition). This reinforcement requires the activation of mineralocorticoid receptors and protein synthesis. The basolateral amygdala (BLA) is known to modulate glucocorticoid effects on the consolidation of spatial/contextual memory via a beta-adrenergic mechanism. Interestingly, hippocampal DG-LTP can also be indirectly modulated by beta-adrenergic and cholinergic/muscarinergic processes. Here, we show that the reinforcement of early-DG-LTP under high-stress conditions depends on the processing of novel spatial/contextual information. Furthermore, this reinforcement was blocked in BLA-lesioned animals compared with sham-operated and intact controls; however, it was not dependent on beta-adrenergic or cholinergic/muscarinergic receptor activation. In contrast, under low-stress conditions, the induction of late-LTP in BLA-lesioned animals is facilitated, and this facilitation, again, was dependent on beta-adrenergic activation. The data suggest that DG-LTP maintenance can be influenced by the BLA through different mechanisms: a short-lasting corticosterone-dependent and beta-adrenergic-independent mechanism and a long-lasting mechanism that facilitated hippocampal beta-adrenergic mechanisms.
Korz
Volker
V
Department of Neurophysiology, Leibniz-Institute for Neurobiology, D-39118 Magdeburg, Germany. korz@ifn-magdeburg.de
Frey
Julietta U
JU
D000679:Amygdala; D000818:Animals; D001927:Brain Diseases / Q000150:complications / Q000503:physiopathology*; D003345:Corticosterone / Q000097:blood; D018891:Dentate Gyrus / Q000503:physiopathology; D004558:Electric Stimulation; D006624:Hippocampus / Q000503:physiopathology*; D017774:Long-Term Potentiation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D012054:Reinforcement, Psychology; D013312:Stress, Physiological / Q000150:complications / Q000209:etiology / Q000503:physiopathology*; D013550:Swimming
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D003345:Corticosterone