title: Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China.
abstract: OBJECTIVE
  To characterize the histochemical type and pattern of intestinal metaplasia (IM) adjacent to gastric cardia adenocarcinoma (GCA) and distal gastric cancer (GC) in Linzhou, Henan Province, China.
  
  
  METHODS
  Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from Linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio- or chemotherapy was not applied to these patients before surgery.
  
  
  RESULTS
  The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues (80.64%, P<0.01). The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues (31.82% and 63.64%, respectively) were significantly higher than those in GC (5.33% and 21.33%, respectively, P<0.01).
  
  
  CONCLUSIONS
  IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.
authors.affiliation: Laboratory for Cancer Research, College of Medicine, Zhengzhou University, Henan Province, China.
authors.forename: She-Gan
authors.initials: SG
authors.lastname: Gao
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Wang
authors.forename: Zong-Min
authors.initials: ZM
authors.lastname: Fan
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Guo
authors.forename: Dong-Ling
authors.initials: DL
authors.lastname: Xie
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: He
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Gao
authors.forename: Hua-Qin
authors.initials: HQ
authors.lastname: Guo
authors.forename: Jun-Kuan
authors.initials: JK
authors.lastname: Wang
authors.forename: Xiao-Shan
authors.initials: XS
authors.lastname: Feng
authors.forename: Bao-Gen
authors.initials: BG
authors.lastname: Ma
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002299:Cardia; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*