General metabolism of the dimorphic and pathogenic fungus Paracoccidioides brasiliensis.
Annotation of the transcriptome of the dimorphic fungus Paracoccidioides brasiliensis has set the grounds for a global understanding of its metabolism in both mycelium and yeast forms. This fungus is able to use the main carbohydrate sources, including starch, and it can store reduced carbons in the form of glycogen and trehalose; these provide energy reserves that are relevant for metabolic adaptation, protection against stress and infectivity mechanisms. The glyoxylate cycle, which is also involved in pathogenicity, is present in this fungus. Classical pathways of lipid biosynthesis and degradation, including those of ketone body and sterol production, are well represented in the database of P. brasiliensis. It is able to synthesize de novo all nucleotides and amino acids, with the sole exception of asparagine, which was confirmed by the fungus growth in minimal medium. Sulfur metabolism, as well as the accessory synthetic pathways of vitamins and co-factors, are likely to exist in this fungus.
Arraes
Fabrício B M
FB
Departamento de Biologia Celular, Universidade de Brasília, 70910-900 Brasília, DF, Brazil.
Benoliel
Bruno
B
Burtet
Rafael T
RT
Costa
Patrícia L N
PL
Galdino
Alexandro S
AS
Lima
Luanne H A
LH
Marinho-Silva
Camila
C
Oliveira-Pereira
Luciana
L
Pfrimer
Pollyanna
P
Procópio-Silva
Luciano
L
Reis
Viviane Castelo-Branco
VC
Felipe
Maria Sueli S
MS
D000596:Amino Acids / Q000378:metabolism; D050260:Carbohydrate Metabolism; D020224:Expressed Sequence Tags / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D010228:Paracoccidioides / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism; D013455:Sulfur / Q000378:metabolism; D014158:Transcription, Genetic
D000596:Amino Acids; D005227:Fatty Acids; D011687:Purines; D011743:Pyrimidines; D013455:Sulfur