title: Isolated central nervous system involvement in adult T-cell lymphoma/leukaemia.
abstract: Central nervous system (CNS) presentation of adult T-cell lymphoma/leukaemia is rare, and almost invariably associated with systemic disease. We report an unusual manifestation of adult T-cell lymphoma/leukaemia, with isolated CNS involvement and unusual imaging findings. We also describe objective response to antiviral therapy. To our knowledge, this is the first report of such presentation and response.
authors.affiliation: Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Dungerwalla
authors.forename: N
authors.initials: N
authors.lastname: Osuji
authors.forename: A D
authors.initials: AD
authors.lastname: Waldman
authors.forename: F
authors.initials: F
authors.lastname: Al Jehani
authors.forename: A
authors.initials: A
authors.lastname: Mehta
authors.forename: R
authors.initials: R
authors.lastname: Tailor
authors.forename: R
authors.initials: R
authors.lastname: Taylor
authors.forename: A
authors.initials: A
authors.lastname: Wotherspoon
authors.forename: G
authors.initials: G
authors.lastname: Cogill
authors.forename: E
authors.initials: E
authors.lastname: Matutes
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D018450:Disease Progression; D005625:Frontal Lobe / Q000601:surgery; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010166:Palliative Care; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D007372:Interferons