title: Epistaxis after PDE-5 inhibitors misuse.
abstract: A 32-year-old male presented to our department for recurrent epistaxis during sexual intercourses. The patient controlled the bleeding each time with sponge packs and gauzes. During the consultation, he volunteered that the trigger for the epistaxis appeared to have been misuse of phosphodiesterase (PDE)-5 inhibitors, Viagra and Cialis. This first report of epistaxis after PDE-5 inhibitors in a young patient underline the possibility that in the next years the number of similar cases might increase due to the diffusion of PDE-5 inhibitor misuse in recreational settings.
authors.affiliation: Urology Unit - University of Pisa, S Chiara Hospital, Via Roma, Pisa, Italy. g.pomara@libero.it
authors.forename: G
authors.initials: G
authors.lastname: Pomara
authors.forename: G
authors.initials: G
authors.lastname: Morelli
authors.forename: F
authors.initials: F
authors.lastname: Menchini-Fabris
authors.forename: N
authors.initials: N
authors.lastname: Dinelli
authors.forename: G
authors.initials: G
authors.lastname: Campo
authors.forename: G
authors.initials: G
authors.lastname: LiGuori
authors.forename: C
authors.initials: C
authors.lastname: Selli
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000328:Adult; D002243:Carbolines / Q000008:administration & dosage / Q000009:adverse effects; D003075:Coitus; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D004844:Epistaxis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects; D011687:Purines; D000068677:Sildenafil Citrate; D019966:Substance-Related Disorders; D013450:Sulfones; D000068581:Tadalafil
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068581:Tadalafil; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; C517381:PDE5A protein, human