title: Nonsuppurative myocarditis caused by porcine circovirus type 2 in a weak-born piglet.
abstract: Reproductive failure associated with porcine circovirus type 2 (PCV2) was observed in a farm, and a weak-born 8-day-old piglet was examined pathologically. Focal to locally extensive lesions, including infiltration of macrophages and lymphocytes, fibrosis and degeneration of the myocardium were observed in the heart. PCV2 antigens and nucleic acids were detected in degenerated cardiomyocytes and macrophages infiltrating the heart by immunohistochemical staining and in situ hybridization. Depletion of lymphocytes with occasional infiltration of multinucleated giant cells was seen in the lymphoid organs and PCV2 antigens were demonstrated in histiocytic cells. Crystalline arrays of viral particles were observed in infiltrated macrophages in the heart and, rarely, in cardiomyocytes by electron microscopy. Although myocarditis is a common finding in aborted or stillborn piglets in reproductive failure due to PCV2, it was also observed in the 8-day-old piglet with PCV2 association.
authors.affiliation: Toxico-Pathology Section, Department of Safety Research, National Institute of Animal Health, Tsukuba, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Mikami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawashima
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yoshii
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D018173:Circoviridae Infections / Q000473:pathology / Q000662:veterinary*; D017925:Circovirus / Q000235:genetics*; D017931:DNA Primers; D007150:Immunohistochemistry / Q000662:veterinary; D017403:In Situ Hybridization / Q000662:veterinary; D008854:Microscopy, Electron / Q000662:veterinary; D009205:Myocarditis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D009206:Myocardium / Q000648:ultrastructure; D016133:Polymerase Chain Reaction; D034421:Sus scrofa; D013553:Swine Diseases / Q000473:pathology* / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D017931:DNA Primers