title: A novel HLA allele, DRB1*1609, identified in the Chinese Han population*.
abstract: A novel human leucocyte antigen-DRB1*16 (HLA-DRB1*16) allele (DRB1*1609) has been identified by sequencing-based typing (SBT) in Chinese Han population. This new allele has identical nucleotide sequence to DRB1*160101 in exon 2, except for a single-nucleotide substitution from A to T at position 127. This change leads to an amino acid change from tyrosine to phenylalanin at residue 47 (Y47F). SBT was performed for cloned DRB1*16-specific polymerase chain reaction fragment. The serological phenotype of DRB1*1609 is equivalent to DR16 antigen.
authors.affiliation: The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiang Su Province, P.R. China.
authors.forename: K R
authors.initials: KR
authors.lastname: Miao
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Pan
authors.forename: M
authors.initials: M
authors.lastname: Xue
authors.forename: X Y
authors.initials: XY
authors.lastname: Zhou
authors.forename: X M
authors.initials: XM
authors.lastname: Fei
authors.forename: Y H
authors.initials: YH
authors.lastname: Tang
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: J W
authors.initials: JW
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Osowski
authors.forename: W X
authors.initials: WX
authors.lastname: Shi
authors.forename: A L
authors.initials: AL
authors.lastname: Xu
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: KuKuruga
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002681:China; D005091:Exons; D005192:Family Health; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010641:Phenotype; D010649:Phenylalanine / Q000737:chemistry; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014443:Tyrosine / Q000737:chemistry
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C506474:HLA-DRB1*16:09 antigen; D014443:Tyrosine; D010649:Phenylalanine