title: High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.
abstract: BACKGROUND
  Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients.
  
  
  RESULTS
  We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matched controls aged <55 years. Venous thrombosis patients had significantly lower levels of HDL particles, large HDL particles, HDL cholesterol, and apolipoprotein AI and significantly higher levels of LDL particles and small LDL particles. The quartile-based odds ratios for decreased HDL particle and apolipoprotein AI levels in patients compared with controls were 6.5 and 6.0 (95% CI, 2.3 to 19 and 2.1 to 17), respectively. Odds ratios for apolipoprotein B/apolipoprotein AI ratio and LDL cholesterol/HDL cholesterol ratio were 6.3 and 2.7 (95% CI, 1.9 to 21 and 1.1 to 6.5), respectively. When polymorphisms in genes for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patients differed significantly from controls in the allelic frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the observed pattern of lower HDL and higher LDL.
  
  
  CONCLUSIONS
  Venous thrombosis in men aged <55 years old is associated with dyslipoproteinemia involving lower levels of HDL particles, elevated levels of small LDL particles, and an elevated ratio of apolipoprotein B/apolipoprotein AI. This dyslipoproteinemia seems associated with a related cholesteryl ester transfer protein genotype difference.
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Deguchi
authors.forename: Natalie M
authors.initials: NM
authors.lastname: Pecheniuk
authors.forename: Darlene J
authors.initials: DJ
authors.lastname: Elias
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Averell
authors.forename: John H
authors.initials: JH
authors.lastname: Griffin
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000145:classification; D008075:Lipoproteins, HDL / Q000097:blood / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012042:Registries; D012307:Risk Factors; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D008074:Lipoproteins; D008075:Lipoproteins, HDL