title: Severe ankylosing spondylitis and diffuse systemic sclerosis: case report of a genetic trap.
abstract: A rare association of ankylosing spondylitis (AS) and systemic sclerosis (SSc) is reported in a Brazilian Mestizo patient presenting a human leucocyte antigen (HLA) genotype that included HLA SSc-susceptibility genes previously reported in different ethnic groups and HLA-B27 associated with AS. The underlying genetic background supporting the full expression of both SSc- and AS-susceptibility alleles and the pertinent literature are discussed.
authors.affiliation: Department of Rheumatology, Sao Paulo Federal University, UNIFESP, São Paulo, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Kayser
authors.forename: M C V
authors.initials: MC
authors.lastname: Alvarenga
authors.forename: A S
authors.initials: AS
authors.lastname: Neves
authors.forename: M
authors.initials: M
authors.lastname: Gerbase-De Lima
authors.forename: L E C
authors.initials: LE
authors.lastname: Andrade
mesh_terms: D000328:Adult; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015796:HLA-B27 Antigen / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D012595:Scleroderma, Systemic / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000235:genetics* / Q000276:immunology
chemical_list: D015796:HLA-B27 Antigen