[Derivates of 1,1-dioxo-1,4,2-benzoditiazines. Part XII. Synthesis and pharmacology of some 6-chloro-3-carboxyalkylamino-7-methyl-1,1-dioxo-1,4,2-benzodithiazines].
Preparation of some novel 6-chloro-3-carboxyalkylamino-7-methyl-1,1-dioxo-1,4,2-benzodithiazines (I-V) and its sodium salts (Ia, IVa) have been elaborated. Their chemical structures have been confirmed by elemental analysis, IR and 1H-NMR spectrometry. In preliminary pharmacological examination compounds I, Ia, IV and IVa exhibited low acute toxicity, moreover investigated compounds shown hypertensive and cholagogic activity (I, Ia) and also hypotensive (IV, IVa) or diuretic (Ia, IVa) activity, on the other hand above mentioned compounds didn't exhibit antiarrhythmic activity. Some relationships between the chemical structure and pharmacological activity of the investigated compounds have also been discussed.
Brzozowski
Z
Z
Zakład Technologii Chemicznej Srodków Leczniczych, Akademia Medyczna, ul. K. Marksa 107, 80-416 Gdańsk.
Sławiński
J
J
Janiec
W
W
Cegieła
U
U
Sliwiński
L
L
Sedlak
I
I
D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002756:Cholagogues and Choleretics / Q000138:chemical synthesis / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000959:Antihypertensive Agents; D002756:Cholagogues and Choleretics; D013843:Thiazines