Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop.
Richie
Jerome P
JP
D000954:Antigens, Surface / Q000096:biosynthesis / Q000235:genetics*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D015536:Down-Regulation / Q000187:drug effects / Q000235:genetics; D005047:Etoposide / Q000494:pharmacology*; D005246:Feedback; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D051218:Lymphocyte Antigen 96; D008297:Male; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology*; D059005:Topoisomerase II Inhibitors; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics; D015533:Transcriptional Activation / Q000187:drug effects / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology; D014410:Tumor Stem Cell Assay; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects* / Q000235:genetics*
D000954:Antigens, Surface; D000972:Antineoplastic Agents, Phytogenic; C493956:CDKN1A protein, human; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; C495377:LY96 protein, human; D051218:Lymphocyte Antigen 96; D059005:Topoisomerase II Inhibitors; D016159:Tumor Suppressor Protein p53; D005047:Etoposide; D004250:DNA Topoisomerases, Type II