title: Predicting cognitive decline in healthy older adults.
abstract: OBJECTIVE
  Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline.
  
  
  METHODS
  A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD).
  
  
  RESULTS
  Baseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD.
  
  
  CONCLUSIONS
  Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
authors.affiliation: OPTIMA, University of Oxford, Dept. of Pharmacology, Oxford, UK.
authors.forename: Celeste
authors.initials: C
authors.lastname: De Jager
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Blackwell
authors.forename: Marc M
authors.initials: MM
authors.lastname: Budge
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Sahakian
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D000849:Anomia / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001245:Association Learning; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011446:Prospective Studies; D011594:Psychometrics; D012016:Reference Values; D012307:Risk Factors