title: Tensides from the group of propylene oxide and ethylene oxide copolymers. X. Solubilization of acetylsalicylic acid by polyetherodiol micelles.
abstract: The process of structural solubilization of acetylsalicylic acid in balanced systems (weight-balanced) by micelles of Rokopols of 30p160 and 30p60 types and, for comparison, by those of F-68 and F-108 Pluronics was investigated. The determined viscosity and hydrodynamic parameters allowed for the calculation of solubilizing activity of polyetherodiol micelles--n(s(A)). The results of the investigation point at Rokopols as an excipient, which may help to obtain new drug delivery systems.
authors.affiliation: Department of Physical Chemistry, Institute of Chemistry, Faculty of Pharmacy, Scholl of Medicine, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
authors.forename: M M
authors.initials: MM
authors.lastname: Zgoda
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D001241:Aspirin / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers; D004852:Epoxy Compounds / Q000737:chemistry; D004987:Ethers / Q000737:chemistry* / Q000493:pharmacokinetics; D005027:Ethylene Oxide / Q000737:chemistry; D008823:Micelles; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D004852:Epoxy Compounds; D004987:Ethers; D008823:Micelles; D011108:Polymers; D013501:Surface-Active Agents; D005027:Ethylene Oxide; D001241:Aspirin; C009068:propylene oxide