Upper vaginectomy for the treatment of vaginal intraepithelial neoplasia.
OBJECTIVE
The purpose of this study was to evaluate the use of upper vaginectomy for the treatment of vaginal intraepithelial neoplasia (VAIN).


METHODS
We conducted a retrospective review. Between August 1, 1985 and April 30, 2004, 105 patients were identified who had undergone upper vaginectomy for VAIN.


RESULTS
Thirty-six patients had previously been treated for VAIN. Mean operative time and estimated blood loss were 55 minutes and 113 mL, respectively. Ten percent had intraoperative complications. Twenty-three (22%) patients had negative findings on final pathologic examination, and invasive cancer was found in 13 (12%) patients. Four patients had postoperative complications. Follow-up was available in 52 patients; 46 (88%) remain without recurrence at a mean follow-up of 25 months.


CONCLUSIONS
In our patients, upper vaginectomy was efficacious for the treatment of VAIN. The procedure led to the diagnosis of occult invasive cancer in 12% of these women.
Indermaur
Megan D
MD
Department of Gynecology Onclogy, University of South Florida, Tampa, FL, USA.
Martino
Martin A
MA
Fiorica
James V
JV
Roberts
William S
WS
Hoffman
Mitchel S
MS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D003127:Colposcopy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D014621:Vagina / Q000601:surgery*; D014625:Vaginal Neoplasms / Q000601:surgery*