Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition.
Src kinase controls cellular adhesions, including cadherin-based intercellular adhesions and integrin-mediated cell-matrix adhesions. In epithelial cells, Src activation, or increased signalling from migratory growth factor receptors via Src, induces an adhesion switch that enhances dynamic cell-matrix adhesions and migratory capacity while suppressing intercellular contact. Moreover, Src and the associated tyrosine kinase FAK are at the heart of the recently identified crosstalk between integrin- and cadherin-mediated adhesions of epithelial cells, particularly during the epithelial-to-mesenchymal transition.
Avizienyte
Egle
E
Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, United Kingdom. e.avizienyte@beatson.gla.ac.uk
Frame
Margaret C
MC
D000818:Animals; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation; D004705:Endocytosis / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000378:metabolism* / Q000502:physiology
D015820:Cadherins; D016023:Integrins; D019061:src-Family Kinases