Ruthenium(II) complexes of 1,12-diazaperylene and their interactions with DNA.
Four complexes of the ligand 1,12-diazaperylene (DAP) have been prepared, [Ru(bpy)n(DAP)(3-n)]2+ where n = 0-2 and [Ru(DAP)3]2+. The [Ru(DAP)3]2+ complex was characterized by X-ray analysis and was found to exhibit the expected propeller-like structure with significant intermolecular pi-stacking interactions. The three Ru(II) complexes showed self-consistent optoelectronic properties with similar ligand-centered pi-pi* absorptions in the range of 333-468 nm and MLCT bands associated with the DAP which increased in intensity and decreased in energy as the number of DAP ligands varied from 1 to 3. Hypochromicity and viscosity changes were observed that were consistent with DAP intercalation into DNA, and binding constants were measured in the range of 1.4-1.6 x 10(6) M(-1) for the mixed ligand complexes. Furthermore, the complex [Ru(bpy)2(DAP)]2+ was found to photocleave plasmid DNA upon irradiation with visible light.
Chouai
Abdellatif
A
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
Wicke
Sara E
SE
Turro
Claudia
C
Bacsa
John
J
Dunbar
Kim R
KR
Wang
Dong
D
Thummel
Randolph P
RP
D001372:Aza Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry; D010777:Photochemistry; D017975:Ruthenium Compounds / Q000737:chemistry*
C510700:1,12-diazaperylene; D001372:Aza Compounds; D017975:Ruthenium Compounds; D010569:Perylene; D004247:DNA