Statics and dynamics of single DNA molecules confined in nanochannels.
The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.
Reisner
Walter
W
Physics Department, Princeton University, New Jersey 08544, USA.
Morton
Keith J
KJ
Riehn
Robert
R
Wang
Yan Mei
YM
Yu
Zhaoning
Z
Rosen
Michael
M
Sturm
James C
JC
Chou
Stephen Y
SY
Frey
Erwin
E
Austin
Robert H
RH
D010582:Bacteriophage lambda / Q000737:chemistry / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry* / Q000276:immunology; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
D004279:DNA, Viral; D012822:Silicon Dioxide