Production of the radioactive antitumoral cisplatin.
This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
Leal
Alexandre S
AS
Division for Radiation Technology, Nuclear Technology Development Centre (CDTN)/National Commission for Nuclear Energy (CNEN), P.O. Box 941, CEP 30123-970, Belo Horizonte, Minas Gerais, Brazil. asleal@sdtn.br
Carvalho Júnior
Alvaro D
AD
Abrantes
Fabiana M
FM
Menezes
Maria Angela de B C
MA
Ferraz
Vany
V
Cruz
Tamara S
TS
Cardoso
Valbert N
VN
de Oliveira
Mônica C
MC
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000528:radiation effects*; D002104:Cadmium / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002945:Cisplatin / Q000493:pharmacokinetics / Q000528:radiation effects*; D010984:Platinum / Q000528:radiation effects*; D011868:Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics
D000970:Antineoplastic Agents; D011868:Radioisotopes; D002104:Cadmium; D010984:Platinum; D002945:Cisplatin