MAO A knockout attenuates adrenocortical response to various kinds of stress.
The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg 8 mice on the corticosterone response to restraint, cold, water deprivation-induced, or social acute stress as well as chronic variable stress was studied. It was found that Tg 8 mice with genetic MAO A knockout and wild-type C3H/HeJ (C3H) strain showed similar plasma corticosterone resting level. MAO A knockout mice differed from C3H mice by attenuated response to restraint (60 min), cold (4 degrees C, 60 min), and water deprivation (48 h) as well as to a chronic (15 days) variable stress. No difference between Tg 8 and C3H strains in the response to psychosocial stress (encounters for 30 min of six previously isolated mice) has been found. ACTH administration to dexamethasone-pretreated mice produced a similar corticosterone effect in Tg 8 and C3H mice, indicating that the decreased stress response in MAO A-deficient mice was due rather to the central mechanisms regulating stress-induced ACTH release than to adrenocortical responsiveness to ACTH.
Popova
Nina K
NK
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Pr. Lavrentieva#10, Novosibirsk 630090, Russia. npopova@bionet.nsc.ru
Maslova
Larissa N
LN
Morosova
Ekaterina A
EA
Bulygina
Veta V
VV
Seif
Isabelle
I
D000302:Adrenal Cortex / Q000201:enzymology* / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D017679:Cryotherapy; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008995:Monoamine Oxidase / Q000235:genetics / Q000378:metabolism*; D012931:Social Environment; D013312:Stress, Physiological / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D013315:Stress, Psychological / Q000097:blood / Q000201:enzymology* / Q000235:genetics
D000324:Adrenocorticotropic Hormone; D008995:Monoamine Oxidase; D003345:Corticosterone