title: Fluid retention mediated by renal PPARgamma.
abstract: Thiazolidinediones are activators of the nuclear receptor PPARgamma with proven efficacy on glucose homeostasis. However, treatment with these drugs often results in fluid retention and edema. Recent studies establish a role for PPARgamma in renal sodium reabsorption, providing a mechanism for the plasma volume expansion induced by these drugs.
authors.affiliation: U545 INSERM Départment d'Athérosclérose Institut Pasteur de Lille and Faculté de pharmacie Université Lille II Lille, France.
authors.forename: Bart
authors.initials: B
authors.lastname: Staels
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D004487:Edema / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology; D014883:Water-Electrolyte Imbalance
chemical_list: D047495:PPAR gamma; D045162:Thiazolidinediones