Anthraquinone derivatives as a new family of protein photocleavers.
Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.
Suzuki
Akane
A
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Hasegawa
Masashi
M
Ishii
Maiko
M
Matsumura
Shuichi
S
Toshima
Kazunobu
K
D000880:Anthraquinones / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D010777:Photochemistry; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014466:Ultraviolet Rays
D000880:Anthraquinones; D011506:Proteins