title: Evaluation of anti-vascular therapy with texture analysis.
abstract: BACKGROUND
  Texture analysis can be used to identify and discriminate between objects in an image and has already been used for the characterization of diseases. The present study evaluated the potential of texture analysis for monitoring tumor cell viability during treatment with an anti-vascular drug.
  
  
  METHODS
  Texture analysis of T2-weighted magnetic resonance images of C3H mammary carcinomas in mice was used to study tumor cell viability during treatment with the anti-vascular drug combretastatin A-4 disodium phosphate (CA4DP). Texture analysis was done by MaZda, and boot strap statistics were used to analyze the results.
  
  
  RESULTS
  The results revealed significant differences in the textures of T2-weighted images when non-tumor tissue and tumor tissue were compared. Furthermore, selected texture parameters were significantly different when image data from before and after CA4DP administration were analyzed.
  
  
  CONCLUSIONS
  Texture analysis is helpful in the diagnosis of different types of tissues, especially when these tissues can not be recognized by human observers. Some functional changes, such as perfusion changes in the tumor, can also be detected by texture analysis.
authors.affiliation: MR Research Center, Aarhus University Hospital, Aarhus, DK8200 Aarhus N, Denmark. gangchen@mr.au.dk
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Sune
authors.initials: S
authors.lastname: Jespersen
authors.forename: Michael
authors.initials: M
authors.lastname: Pedersen
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
authors.forename: Michael R
authors.initials: MR
authors.lastname: Horsman
authors.forename: Hans
authors.initials: H
authors.lastname: Stødkilde Jørgensen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D005260:Female; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; C058728:fosbretabulin