Is there any sense in antisense editing?
Several recent studies have hypothesized that sense-antisense RNA-transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. We studied human and mouse genomic antisense regions and found that the editing level in these areas is negligible. This observation questions the scope of sense-antisense duplexes formation in-vivo, which is the basis for several proposed regulatory mechanisms.
Neeman
Yossef
Y
Compugen Ltd, 72 Pinchas Rosen St, Tel-Aviv 69512, Israel.
Dahary
Dvir
D
Levanon
Erez Y
EY
Sorek
Rotem
R
Eisenberg
Eli
E
D020087:Alu Elements / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D023281:Genomics / Q000379:methods*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017393:RNA Editing / Q000235:genetics*; D016372:RNA, Antisense / Q000235:genetics*; D012330:RNA, Double-Stranded / Q000235:genetics*
D016372:RNA, Antisense; D012330:RNA, Double-Stranded