[Expressions of tumor necrosis factor receptor I and II in human gastric carcinoma].
OBJECTIVE
To study the clinical significance of expressions of tumor necrosis factor receptor I and II(TNFR I and II) and their relationship with clinical pathology in human gastric carcinoma.


METHODS
SABC immunohistochemical method was used to examine the expressions of TNFR I and II in 51 cases of gastric carcinoma, 41 adjacent mucosal and 15 normal gastric mucosa tissues.


RESULTS
The positivity rates of TNFR I and II expressions in human gastric carcinoma were significantly higher than those in the adjacent mucosal and normal mucosal tissues, and their expressions were significantly higher in the surrounding mucosa than in the normal tissues. In gastric carcinoma tissues, no correlations of TNFR I and II expressions with serous membrane invasion or lymph node metastasis were found, but the differentiation grade was positively correlated with TNFR expressions (r=-0.3111, P=0.035; r=-0.5952, P=0.000, respectively).


CONCLUSIONS
TNFR I and II expressions are valuable indicators for determining the malignancy and predicting the differentiation grade of gastric carcinoma.
Gao
Lei
L
Department of Ultrasound, Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
Bai
Lan
L
Nan
Qing-zhen
QZ
Cai
Li-shan
LS
Cui
Jian-chang
JC
Dai
Jiu-long
JL
Lin
Yong
Y
Shen
Qiang
Q
D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000096:biosynthesis*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II