title: Quantitative analysis of left atrial function during left ventricular ischemia with and without left atrial ischemia: a real-time 3-dimensional echocardiographic study.
abstract: Left atrial (LA) systolic and diastolic function were analyzed in an animal model of acute left ventricular ischemia with LA ischemia by proximal left circumflex coronary artery occlusion or without LA ischemia by midleft anterior descending coronary artery occlusion (7 sheep in each group). LA pressures and LA volumes were simultaneously recorded using a catheter and real-time 3-dimensional echocardiography, respectively. LA stroke volume represented 63% of left ventricular stroke volume during left anterior descending coronary artery occlusion, but only 32% during left circumflex coronary artery occlusion. This animal study with 3-dimensional echocardiographic determination of absolute LA volumes demonstrated dramatic depression of LA function during proximal left circumflex coronary artery occlusion as compared with left anterior descending coronary artery occlusion.
authors.affiliation: Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bauer
authors.forename: Michael
authors.initials: M
authors.lastname: Jones
authors.forename: Jian Xin
authors.initials: JX
authors.lastname: Qin
authors.forename: Peter
authors.initials: P
authors.lastname: Castro
authors.forename: Junko
authors.initials: J
authors.lastname: Asada
authors.forename: Marta
authors.initials: M
authors.lastname: Sitges
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Cardon
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsujino
authors.forename: Arthur D
authors.initials: AD
authors.lastname: Zetts
authors.forename: Julio A
authors.initials: JA
authors.lastname: Panza
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiota
mesh_terms: D000818:Animals; D016279:Atrial Function, Left / Q000502:physiology*; D001794:Blood Pressure; D019560:Echocardiography, Three-Dimensional; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008026:Ligation; D023421:Models, Animal; D009200:Myocardial Contraction / Q000502:physiology; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012756:Sheep; D013318:Stroke Volume; D014682:Vena Cava, Inferior; D016277:Ventricular Function, Left / Q000502:physiology*