Novel inhibitors of the hepatitis C virus NS3 proteinase.
The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.
Bennett
Frank
F
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. frank.bennett@spcorp.com
Liu
Yi-Tsung
YT
Saksena
Anil K
AK
Arasappan
Ashok
A
Butkiewicz
Nancy
N
Dasmahapatra
Bimalendu
B
Pichardo
John S
JS
Njoroge
F George
FG
Patel
Naginbhai M
NM
Huang
Yuhua
Y
Yang
Xiaozheng
X
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D019281:Dimerization; D006526:Hepatitis C / Q000201:enzymology*; D020128:Inhibitory Concentration 50; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D000998:Antiviral Agents; D011725:Pyridines; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases