Lymphocytic myocarditis after lung transplantation.
This study reports the development of lymphocytic myocarditis in a bilateral lung allograft recipient. A 23-year-old woman developed congestive heart failure and severe left ventricular dysfunction 32 months after a bilateral lung allograft for cystic fibrosis. She had taken oral acyclovir for infectious mononucleosis that was diagnosed 11 months previously. Her viral load for Epstein-Barr virus (EBV) increased, and an echocardiogram revealed a left ventricular ejection fraction of 25% and endomyocardial biopsy revealed lymphocytic myocarditis. She received valacyclovir (1 g x 3 times daily) and made a full recovery 6 months later.
Weinkauf
Justin
J
Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, California, USA.
Walia
Rajat
R
Berry
Gerald J
GJ
Vagelos
Randall
R
Faul
John L
JL
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D001707:Biopsy, Needle; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D007244:Infectious Mononucleosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects* / Q000379:methods; D008214:Lymphocytes / Q000473:pathology; D009205:Myocarditis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives
D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir