Pyrimidines as the chemotherapeutic drugs.
Investigations on new chemotherapeutic drugs have attracted a worldwide interest during the past few years. The pyrimidine derivatives possessing such the activity have a considerable pharmaceutical significance. The works on these compounds are led in various directions, but a particular importance have modifications of the drug Trimetoprime as well as syntheses of new pipemidic acid derivatives and pyrimidines with the amide group.
Cieplik
J
J
Department of Organic Chemistry, School of Medicine, 9 Grodzka Str., 50-137 Wrocław, Poland.
Królicki
Z A
ZA
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D010876:Pipemidic Acid / Q000138:chemical synthesis / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D014295:Trimethoprim; D010876:Pipemidic Acid