Identification of a new HLA-B variant, HLA-B*5615.
A new HLA-B allele, B*5615, has been identified in a Caucasian individual by sequence-based typing. This allele shows a sequence identical to that of HLA-B*5601 except for two nucleotide substitutions that cause a change from TTA to TAC at codon 116 and an amino acidic change from Leucine to Tyrosine in the mature protein.
Frison
S
S
Dipartimento Trasfusionale e di Riferimento per i Trapianti di Organi, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena-Fondazione IRCCS di Natura Pubblica, Milano, Italy.
Longhi
E
E
de Arias
A E
AE
Andreini
E
E
Scalamogna
M
M
Poli
F
F
D000483:Alleles; D001483:Base Sequence; D003062:Codon; D005091:Exons; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D007930:Leucine / Q000235:genetics; D008969:Molecular Sequence Data; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014443:Tyrosine / Q000235:genetics
D003062:Codon; D015235:HLA-B Antigens; C506471:HLA-B*56:15 antigen; D014443:Tyrosine; D007930:Leucine