title: [Molecular and genetic characterization of rifampicin- and/or izoniazid-resistent strains of M. tuberculosis, isolated in Novosibirsk and Tomsk regions].
abstract: The purpose of the work was to study rifampicin- and izoniazid-resistent strains of M. tuberculosis, circulating in Western Siberia, by VNTR and IS6110 typing. The authors also studied genetic causes of resistance to these antibiotics and undertook a search of new VNTR loci, displaying polymorphism in genomes of closely related clonally-disseminated variants of Mycobacterium tuberculosis in W-Beijing family model analysis.
authors.forename: S I
authors.initials: SI
authors.lastname: Tat'kov
authors.forename: O V
authors.initials: OV
authors.lastname: Norkina
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Sivkov
authors.forename: A N
authors.initials: AN
authors.lastname: Boldyrev
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Azaev
authors.forename: V N
authors.initials: VN
authors.lastname: Kinsht
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Kurunov
authors.forename: V A
authors.initials: VA
authors.lastname: Krasnov
authors.forename: E V
authors.initials: EV
authors.lastname: Medvedeva
authors.forename: O I
authors.initials: OI
authors.lastname: Baranova
authors.forename: A P
authors.initials: AP
authors.lastname: Ivlev-Duntau
authors.forename: S A
authors.initials: SA
authors.lastname: Bodnev
authors.forename: L N
authors.initials: LN
authors.lastname: Blinova
authors.forename: A D
authors.initials: AD
authors.lastname: Pasechnikov
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D018598:Minisatellite Repeats / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D012294:Rifamycins / Q000494:pharmacology*; D012800:Siberia / Q000453:epidemiology; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D012294:Rifamycins; D007538:Isoniazid