[The relationship between the C589T polymorphism of IL-4 gene and cholelithiasis].
OBJECTIVE
To investigate the relationship between IL-4 gene polymorphism and cholelithiasis in Chinese population.


METHODS
Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of IL-4 gene in 81 cholecystolithiasis, 41 patients with biliary duct stone.


RESULTS
There were no significant differences of the IL-4 gene polymorphism genotypes and alleles between 81 cholecystolithiasis patients (CC11.1%, CT34.6%, TT54.3%; C28.4.7%, T71.6%). There were significant differences of the IL-4 gene polymorphism genotypes and alleles between 41 patients with biliary duct stone (CC48.8%, CT36.6%, TT14.6%; C67.1%, T32.9%).


CONCLUSIONS
The C589T polymorphism of IL-4 gene was not associated with cholecystolithiasis patients in Chinese, but was related to patients with biliary duct stone in Chinese.
Zhuang
Xiao-ming
XM
Department of General Surgery, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, China.
Xiao
Hong
H
Zhang
Yuan
Y
D000328:Adult; D044466:Asian People; D041761:Cholecystolithiasis / Q000208:ethnology / Q000235:genetics*; D042883:Choledocholithiasis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics
D015847:Interleukin-4