title: Development of ultra short-acting muscle relaxant agents: history, research strategies, and challenges.
abstract: Author has reviewed the literature and his own work related to the chemistry, pharmacology, and clinical aspects of new muscle relaxants. Emphasis has been placed on the basic science concepts and technologies (e.g. structure-activity relationships, nicotinic receptor pharmacology, and investigation of side effects) behind the development of rapidly and short acting nondepolarizing muscle relaxants.
authors.affiliation: Department of Anesthesiology, Harbor-UCLA Medical Center, Box 10, 1000 W. Carson Street, Torrance, California 90509, USA. laslogy@cox.net
authors.forename: Laszlo
authors.initials: L
authors.lastname: Gyermek
mesh_terms: D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D003503:Cyclobutanes / Q000494:pharmacology; D015195:Drug Design; D004594:Electrophysiology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D009125:Muscle Relaxants, Central / Q000737:chemistry; D009466:Neuromuscular Blocking Agents / Q000737:chemistry / Q000493:pharmacokinetics; D009467:Neuromuscular Depolarizing Agents / Q000737:chemistry; D003473:Neuromuscular Nondepolarizing Agents / Q000737:chemistry; D011976:Receptors, Muscarinic / Q000737:chemistry / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000737:chemistry / Q000187:drug effects; D013256:Steroids / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013610:Tachycardia / Q000139:chemically induced; D013997:Time Factors
chemical_list: D003503:Cyclobutanes; D007546:Isoquinolines; D009125:Muscle Relaxants, Central; D009466:Neuromuscular Blocking Agents; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D013256:Steroids; C003731:truxillic acid; C451919:gantacurium