Molecular study of the hematopoietic zinc finger gene in three unrelated families with gray platelet syndrome.
Hematopoietic zinc finger (HZF) null mice have features reminiscent of patients with gray platelet syndrome (GPS), a rare inherited bleeding disorder. This similarity has suggested that HZF deregulation might be involved in the human disease. The sequence of the eight exons of the HZF gene as well as the study of its expression in blood samples from five patients belonging to three different families did not reveal any modifications when compared with healthy donors. This study indicates that HZF is unlikely to be responsible for GPS.
Bénit
L
L
Département d'hématologie, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes Paris, Faculté de Médecine Paris-Ile de France-Ouest (UVSQ), Paris, France. benit@cochin.inserm.fr
Cramer
E M
EM
Massé
J M
JM
Dusanter-Fourt
I
I
Favier
R
R
D001791:Blood Platelet Disorders / Q000235:genetics*; D016022:Case-Control Studies; D005091:Exons; D005192:Family Health; D006801:Humans; D008533:Megakaryocytes / Q000737:chemistry; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis; D016335:Zinc Fingers / Q000235:genetics
D012333:RNA, Messenger