Is sudden death with vitamin C deficiency caused by lack of carnitine?
We investigated the effect of carnitine supplementation during vitamin C (ASC) deficiency by measuring the levels of ASC and carnitine in plasma and cardiac muscle cells (CMC), and histological analysis with electron microscopy. The levels of carnitine were significantly decreased in ASC-deficient rats in plasma and the heart than those in the control. In carnitine supplemented ASC-deficient rats, a significant increase of carnitine levels were observed in both plasma and heart. The number of lipid droplets significantly increased in the ASC-deficient rats compared to the control rats, but did not increase in carnitine supplemented rats. These results indicate that ASC deficiency causes a generalized mitochondrial abnormality and accumulation of lipid droplets in CMC as observed in carnitine deficiency, and supplementation of carnitine prevented these changes even in the presence of ASC deficiency.
Okamoto
Maya
M
Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan. myok@med.kobe-u.ac.jp
Ueno
Yasuhiro
Y
D000818:Animals; D001206:Ascorbic Acid Deficiency / Q000097:blood / Q000209:etiology / Q000473:pathology*; D001344:Autopsy; D002331:Carnitine / Q000097:blood / Q000172:deficiency* / Q000378:metabolism; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000473:pathology*; D005260:Female; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D002331:Carnitine