[Pathogenesis of Barrett's esophagus--new findings in the experimental studies of duodenal reflux models].
Duodeno-gastro-esophageal reflux has been thought to induce Barrett's esophagus. Recently, we designed a new duodenal reflux model using rats, and studied sequential morphological changes of esophageal mucosa leading to Barrett's esophagus. A specialized columnar epithelium (SCE) developed 20 weeks after operation. Barrett's epithelium originated from pyloric-foveolar metaplasia of stem cells in the basal layer of the esophageal squamous epithelium. The pyloric-foveolar metaplasia was then followed by the appearance of goblet cells, becoming a typical SCE. The expression of homeobox gene Cdx2 was seen in this process, thereby suggesting a role of Cdx2 in intestinal differentiation of Barrett's esophagus. We noticed the pyloric-foveolar metaplasia followed by the appearance of goblet cells is common to entire gut in regenerative process, and proposed a concept of GRCL (gut regenerative cell lineage), and an implication of GRCL in digestive tract carcinogenesis was discussed.
Hattori
Takanori
T
Department of Pathology, Shiga University of Medicine Science.
Mukaisho
Ken-ichi
K
Miwa
Koichi
K
D000818:Animals; D001471:Barrett Esophagus / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D000071616:CDX2 Transcription Factor; D004195:Disease Models, Animal; D004383:Duodenogastric Reflux / Q000150:complications*; D004947:Esophagus / Q000166:cytology / Q000473:pathology; D015870:Gene Expression; D020397:Goblet Cells / Q000473:pathology; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology; D008679:Metaplasia / Q000235:genetics; D009092:Mucous Membrane / Q000166:cytology / Q000473:pathology; D051381:Rats; D012038:Regeneration / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
D000071616:CDX2 Transcription Factor; C487514:Cdx2 protein, mouse; D018398:Homeodomain Proteins; D014157:Transcription Factors