High-performance liquid chromatographic determination of ethosuximide in plasma.
A HPLC method for a rapid determination of ethosuximide in plasma is described. A sample is extracted with ethyl ether from acidic medium with glutethimide as internal standard and injected onto analytical RP-18 column with spectrophotometric monitoring at 244 nm.
Zawisza
P
P
Department of Medicinal Chemistry, School of Medicine, 1 Okopowa Str., 20-022 Lublin, Poland.
Przyborowski
L
L
D000927:Anticonvulsants / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005013:Ethosuximide / Q000097:blood*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013053:Spectrophotometry
D000927:Anticonvulsants; D005013:Ethosuximide