title: Pulmonary aspiration of gastric contents and the sudden infant death syndrome.
abstract: OBJECTIVE
  To determine ante-mortem and post-mortem risk factors for the finding of gastric contents in pulmonary airways (aspiration of gastric contents) at post-mortem examination in the sudden infant death syndrome (SIDS).
  
  
  METHODS
  There were 217 post-neonatal deaths in the Auckland region of the New Zealand Cot Death Study. No deaths were certified as due to aspiration of gastric contents. There were 138 SIDS cases. The parents of 110 (80%) of these cases were interviewed. Histological sections from the periphery of the lungs in 99 of the 110 cases were reviewed for evidence of aspiration of gastric contents. A wide range of variables were analysed in SIDS cases with and without aspiration to determine risk factors.
  
  
  RESULTS
  Aspiration of gastric contents was identified in 37 (37%) of SIDS cases. Aspiration was of mild-to-moderate degree and in no case was severe and a potential cause of death. Finding infants on their backs at death (P = 0.024) and conducting the post-mortem on the day after the death or subsequently (P = 0.033) were statistically significant variables linked to identification of aspiration. Position placed to sleep, symptoms of gastro-oesophageal reflux and other variables were not related to aspiration.
  
  
  CONCLUSIONS
  The only determinants for aspiration of gastric contents identified were agonal or post-mortem events, supporting the contention that aspiration has limited relevance to the mechanism of SIDS.
authors.affiliation: Department of Paediatrics, University of Auckland, Auckland, New Zealand.
authors.forename: Nishi
authors.initials: N
authors.lastname: Alex
authors.forename: John M D
authors.initials: JM
authors.lastname: Thompson
authors.forename: David M O
authors.initials: DM
authors.lastname: Becroft
authors.forename: Ed A
authors.initials: EA
authors.lastname: Mitchell
mesh_terms: D001237:Asphyxia; D001344:Autopsy; D002423:Cause of Death; D005766:Gastrointestinal Contents; D006801:Humans; D007223:Infant; D009520:New Zealand; D016684:Prone Position; D013398:Sudden Infant Death / Q000209:etiology*; D016683:Supine Position