Studies on the products of conversion of 4-ethoxycarbonylmethyl-1,2,4-triazoline-5-thione. VII. Synthesis of 4-beta-acetylaminoethyl derivatives of 1,2,4-triazoline-5-thione.
In the reaction of 4-ethoxycarbonylmethyl-1,2,4-triazoline-5-thione derivatives (Ia,b) with the primary amines the corresponding amides (IIa,b-IVa,b) have been formed. These amides were then undergone to reduction with LiAlH4 leading to the formation of corresponding amines (Va,b-VIIa,b). Then by means of the reaction with acetic anhydride these amines were transformed into corresponding acetylamine derivatives of 1,2,4-triazoline-5-thione (VIIIa,b-Xa,b).
Dobosz
M
M
Department of Organic Chemistry, School of Medicine, 6 Staszica Str., 20-081 Lublin, Poland.
Pachuta-Stec
A
A
Rekas
J
J
D000089:Acetic Anhydrides / Q000737:chemistry; D000107:Acetylation; D000588:Amines / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013854:Thioamides / Q000737:chemistry; D013871:Thiones / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D000089:Acetic Anhydrides; D000588:Amines; D013854:Thioamides; D013871:Thiones; D014230:Triazoles; C045575:1,2,4-triazole; C031800:acetic anhydride