Boolean control of aptamer binding states.
Molecules that perform Boolean calculations can analyze a series of inputs and make a decision to produce or not to produce an output, based on the presence or absence of inputs and a particular formula they encode. We now report that molecular computation performed by deoxyribozyme-based logic gates can be used to control the functional state of aptamers, switching them on or off based on the outcome of such computation.
Kolpashchikov
Dmitry M
DM
Division of Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630W 168th Street, New York, New York 10032, USA.
Stojanovic
Milan N
MN
D039301:Computers, Molecular; D021881:DNA, Catalytic / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*
D021881:DNA, Catalytic; D009841:Oligonucleotides