Is APC activation of endothelial cell PAR1 important in severe sepsis?: Yes.
Ruf
W
W
Department of Immunology, SP258, The Scripps Research Institute, La Jolla, CA 92037, USA. ruf@scripps.edu
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D011486:Protein C / Q000378:metabolism / Q000502:physiology*; D044463:Receptor, PAR-1 / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D018805:Sepsis / Q000473:pathology*; D015398:Signal Transduction
D001779:Blood Coagulation Factors; D011486:Protein C; D044463:Receptor, PAR-1; D011956:Receptors, Cell Surface; C091963:activated protein C receptor