Regional lymph node staging using lymphotropic nanoparticle enhanced magnetic resonance imaging with ferumoxtran-10 in patients with penile cancer.
OBJECTIVE
We evaluated lymphotropic nanoparticle enhanced magnetic resonance imaging (LNMRI) with ferumoxtran-10 in determining the presence of regional lymph node metastases in patients with penile cancer.


METHODS
Seven patients with squamous cell carcinoma of the penis underwent LNMRI. All patients subsequently underwent groin dissection and the nodal images were correlated with histology.


RESULTS
We found that LNMRI had sensitivity, specificity, and positive and negative predictive values of 100%, 97%, 81.2% and 100%, respectively, in predicting the presence of regional lymph node metastases in patients with penile cancer.


CONCLUSIONS
Lymph node scanning using LNMRI accurately predicts the pathological status of regional lymph nodes in patients with cancer of the penis. LNMRI may accurately triage patients for regional lymphadenectomy.
Tabatabaei
Shahin
S
Department of Urology, The Massachusetts General Hospital and The Harvard Medical School, Boston, Massachusetts 02114, USA.
Harisinghani
Mukesh
M
McDougal
W Scott
WS
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D006119:Groin; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007501:Iron; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D049329:Nanostructures; D009367:Neoplasm Staging / Q000379:methods*; D010087:Oxides; D010412:Penile Neoplasms / Q000473:pathology* / Q000601:surgery; D010413:Penis / Q000473:pathology / Q000601:surgery; D012086:Reoperation; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide