title: Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*.
abstract: DOA sequences are currently known to have identical protein sequences. However, in this study, we report four novel allele types of human leucocyte antigen-DOA, including one synonymous and three non- synonymous amino acid changes from the Korean population. DOA*010106 has identical protein sequence with previously known DOA*010103 except one nucleotide difference at codon 45 (TCG-->TCA). In contrast, DOA*0102 and DOA*0103 have a sequence change at codon 99 (CTG-->GTG) and codon 105 (CGC-->TGC), causing non-synonymous amino acid changes, Leu99Val and Arg105Cys, respectively. In addition, DOA*0104N has a sequence deletion at codon 36 (CCC-->CC-), resulting in a frame shift leading to a stop codon at codon 62.
authors.affiliation: National Genome Research Institute, National Institute of Health, Eunpyung-Gu, Seoul, Korea.
authors.forename: S-M
authors.initials: SM
authors.lastname: Moon
authors.forename: H
authors.initials: H
authors.lastname: Gu
authors.forename: H-J
authors.initials: HJ
authors.lastname: Ryu
authors.forename: J-J
authors.initials: JJ
authors.lastname: Kim
authors.forename: H-T
authors.initials: HT
authors.lastname: Kim
authors.forename: B-G
authors.initials: BG
authors.lastname: Han
authors.forename: K
authors.initials: K
authors.lastname: Kimm
authors.forename: J-K
authors.initials: JK
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Oh
mesh_terms: D000483:Alleles; D001483:Base Sequence; D003062:Codon; D018388:Codon, Terminator; D017931:DNA Primers / Q000235:genetics; D016368:Frameshift Mutation; D005802:Genes, MHC Class II; D006681:HLA-D Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D003062:Codon; D018388:Codon, Terminator; D017931:DNA Primers; D006681:HLA-D Antigens