Prognostic impact of p53 protein overexpression in patients with node-negative lung adenocarcinoma.
Prognostic value of p53 protein expression in node-negative lung adenocarcinoma is still controversy. The expression of p53 protein was examined immunohistochemically in lung adenocarcinoma using monoclonal antibody BP53-12. A total 131 cases of primary lung adenocarcinoma were examined. Relationship between expression of p53 protein and clinicopathologic factors were studied. Overexpression of p53 protein was found in 19 patients (14.5%). Univariate and multivariate analysis showed that overexpression of p53 protein was an independent prognostic factor in node-negative lung adenocarcinoma. p53 alteration could be a valuable predictor for prognosis in node-negative lung adenocarcinoma.
Suzuki
Hiroyuki
H
Department of Surgery I, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. hiro@fmu.ac.jp
Kawaguchi
Takanori
T
Hasegawa
Takeo
T
Yonechi
Atsushi
A
Ohsugi
Jun
J
Higuchi
Mitsunori
M
Yamada
Fumihiko
F
Shio
Yutaka
Y
Fujiu
Koichi
K
Kanno
Ryuzo
R
Ohishi
Akio
A
Gotoh
Mitsukazu
M
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53