title: [Immune alterations in patients with laryngeal cancer at different stages].
abstract: The immune status was studied in 162 patients with laryngeal cancer (T2N0M0, T3N0M0, T4N1MX). Progression in these patients was associated with suppression of specific mechanisms of immune defense -- cytolysis of target cells and activation of CD4(+) lymphocytes. Cytolytic mechanisms were not compensated by involvement of other defense mechanisms, i.e. nonspecific, natural killers mediated. Dysgammaglobulinemia detected in laryngeal cancer patients can be considered as alteration associated with tumor damage to mucosa.
authors.forename: E V
authors.initials: EV
authors.lastname: Khrustaleva
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D015703:Antigens, CD; D006684:HLA-DR Antigens; D007136:Immunoglobulins