Wegener's granulomatosis with eosinophilia.
Wegener's granulomatosis with eosinophilia both in blood and tissue samples has been rarely reported. A 25-year-old woman developed fever, granulomatous inflammation of nasal mucosa, pulmonary hemorrhage, suprascleritis, and cutaneous vasculitis. She showed eosinophilia in blood and biospy samples of skin, nasal mucosa, and lung. She was positive for proteinase 3-antineutrophil cytoplasmic antibody. She had no history of asthma. We diagnosed her as Wegener's granulomatosis with eosinophilia rather than Churg-Strauss syndrome. Her mucocutaneous and pulmonary lesions were successfully treated with high-dose corticosteroid and methotrexate, but her suprascleritis required pulsed cyclophosphamide.
Shoda
Hirofumi
H
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo.
Kanda
Hiroko
H
Tanaka
Ryouichi
R
Komagata
Yoshiaki
Y
Misaki
Yoshikata
Y
Yamamoto
Kazuhiko
K
D000328:Adult; D001168:Arthritis / Q000209:etiology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004802:Eosinophilia / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008168:Lung / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D009297:Nasal Mucosa / Q000473:pathology; D015423:Scleritis / Q000188:drug therapy / Q000209:etiology
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008727:Methotrexate