title: Comparative histologic assessment of proctocolectomy specimens from Japanese and American patients with ulcerative colitis with or without dysplasia.
abstract: There have been no reports of histologic differences in ulcerative colitis (UC) between Japanese and American patients. We therefore compared histology in proctocolectomy resection specimens between Japanese patients with UC (19 cases with and 21 without dysplasia) at the Kitasato University East Hospital and American patients with UC (21 cases with and 24 without dysplasia) at the University of Washington Medical Center. In cases of UC with, but not without dysplasia, cryptitis (p = 0.010) and epithelial apoptosis (p < 0.001) in the nondysplastic mucosa were more frequently observed in Japanese than in American cases, whereas lamina propria fibrosis was more prominent in American counterparts (p = 0.008). In patients with UC with dysplasia, the duration of disease was significantly longer in American than in Japanese patients (median, 17 vs 14 years, respectively; p = 0.038). This might, in part, explain the histologic variation. Another possibility for the differences is that the preoperative medications may have differed in the populations.
authors.affiliation: Department of Clinical Research Laboratory, National Sagamihara Hospital, 18-1 Sakura-dai, Sagamihara, Kanagawa, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mitomi
authors.forename: Isao
authors.initials: I
authors.lastname: Okayasu
authors.forename: Mary P
authors.initials: MP
authors.lastname: Bronner
authors.forename: Hideki
authors.initials: H
authors.lastname: Kanazawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Otani
authors.forename: Miwa
authors.initials: M
authors.lastname: Sada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanabe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Igarashi
authors.forename: Tomoe
authors.initials: T
authors.lastname: Katsumata
authors.forename: Katsunori
authors.initials: K
authors.lastname: Saigenji
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis; D003093:Colitis, Ulcerative / Q000208:ethnology* / Q000473:pathology* / Q000601:surgery; D003106:Colon / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000208:ethnology* / Q000473:pathology / Q000601:surgery; D016737:Proctocolectomy, Restorative; D013997:Time Factors; D014481:United States / Q000208:ethnology