Antisense oligonucleotide therapy in the management of bladder cancer.
OBJECTIVE
In this paper, we will review the recent advances in antisense oligonucleotide therapy in the treatment of superficial bladder cancer. Bladder cancer has an exciting potential as a model to study antisense oligonucleotide therapy because of the ease of accessibility of treatment, ease of diagnosis through biopsy and urine cytology, and direct observation of treatment efficacy through cystoscopy and posttreatment biopsy.


RESULTS
We will elaborate on the recent developments in the delivery of antisense oligonucleotide and the implications of these results on the use of antisense oligonucleotide intravesically. We will also discuss recent preclinical in-vitro results of antisense oligonucleotide therapy in different bladder cancer cell lines.


CONCLUSIONS
Recent developments of the in-vitro and animal in-vivo effectiveness of antisense treatment in bladder cancer provide the foundation to pursue future phase I clinical trials. Antisense oligonucleotide technology is a promising tool that may become an effective method of treating bladder cancer.
So
Alan
A
The Prostate Centre at Vancouver General Hospital, University of British Columbia, Canada. aso@vanhosp.bc.ca
Rocchi
Palma
P
Gleave
Martin
M
D000818:Animals; D045744:Cell Line, Tumor; D051152:Clusterin / Q000037:antagonists & inhibitors; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
D051152:Clusterin; D006360:Heat-Shock Proteins; D016376:Oligonucleotides, Antisense