Ectopic pregnancy is not more likely following fresh vs frozen embryo transfer.
OBJECTIVE
To determine if the risk of ectopic pregnancy is greater following frozen vs fresh embryo transfer (ET).


METHODS
Retrospective review of pregnancy outcome from January 1, 1997 to November 30, 2003. Cryopreservation was used as a simple freezing method and one-step removal of cryoprotectant. The cycles consisted mostly of graduated estradiol and progesterone supplementation.


RESULTS
The ectopic pregnancy rate in 1,445 clinical pregnancies from fresh ET was 2.6% vs 2.0% of 975 clinical pregnancies resulting from frozen ET.


CONCLUSIONS
In contrast to the conclusions of two previous studies, the present study evaluating twice as many clinical pregnancies than the two aforementioned studies combined failed to show any greater risk of ectopic pregnancy when transfers were performed on day 3.
Check
J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden, NJ, USA.
Choe
J K
JK
Katsoff
B
B
Krotec
J W
JW
Nazari
A
A
D000328:Adult; D015331:Cohort Studies; D015925:Cryopreservation; D004624:Embryo Transfer / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic / Q000453:epidemiology* / Q000209:etiology*; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment