title: Volume conductor effects involved in the genesis of the P wave.
abstract: OBJECTIVE
  To assess the effect of inhomogeneities in the conductivity of different tissues, such as blood and lung tissue, on the body surface potentials generated by atrial electrical activity.
  
  
  METHODS
  A 64-lead ECG from a healthy subject was recorded. The subject's geometries of torso, lungs, heart, and blood cavities were derived by magnetic resonance imaging. These geometries were used to construct a numerical volume conductor model. The boundary element method was applied to simulate the potentials on the surface of the thorax generated by the atria. The equivalent double layer served as the source description during depolarization. Recorded body surface potentials were used as a check on the simulations. Subsequently, the conductivities in the model were varied to determine their influence on P wave morphology and amplitude.
  
  
  RESULTS
  The model with realistic conductivity values for blood and lungs produced potentials that closely matched the measured ones (correlation 98%). The subsequent variation of conductivity of blood and lungs revealed a major influence on P wave morphology and amplitude: a mean reduction in amplitude by 42%, with pronounced inter-lead differences.
  
  
  CONCLUSIONS
  The inhomogeneities of lungs and atrial blood cavities need to be incorporated in volume conductor models linking atrial electric activity to body surface potentials.
authors.affiliation: Research, Vitatron, Arnhem, The Netherland. peter.van.dam@vitatron.com
authors.forename: Peter M
authors.initials: PM
authors.lastname: van Dam
authors.forename: Adriaan
authors.initials: A
authors.lastname: van Oosterom
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D018780:Body Surface Potential Mapping / Q000379:methods*; D003198:Computer Simulation; D004553:Electric Conductivity; D004562:Electrocardiography; D006325:Heart Atria; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008955:Models, Cardiovascular; D012815:Signal Processing, Computer-Assisted