title: Colorectal cancer: mutations in a signalling pathway.
abstract: Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.
authors.affiliation: The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.
authors.forename: D Williams
authors.initials: DW
authors.lastname: Parsons
authors.forename: Tian-Li
authors.initials: TL
authors.lastname: Wang
authors.forename: Yardena
authors.initials: Y
authors.lastname: Samuels
authors.forename: Alberto
authors.initials: A
authors.lastname: Bardelli
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Cummins
authors.forename: Laura
authors.initials: L
authors.lastname: DeLong
authors.forename: Natalie
authors.initials: N
authors.lastname: Silliman
authors.forename: Janine
authors.initials: J
authors.lastname: Ptak
authors.forename: Steve
authors.initials: S
authors.lastname: Szabo
authors.forename: James K V
authors.initials: JK
authors.lastname: Willson
authors.forename: Sanford
authors.initials: S
authors.lastname: Markowitz
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Kinzler
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
authors.forename: Christoph
authors.initials: C
authors.lastname: Lengauer
authors.forename: Victor E
authors.initials: VE
authors.lastname: Velculescu
mesh_terms: D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D016133:Polymerase Chain Reaction; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases