Pathology and genetics of primary central nervous system and intraocular lymphoma.
Ongoing studies based on gene expression profile analysis using microarrays have provided preliminary evidence for significant molecular distinctions between primary central nervous system lymphoma (PCNSL) and nodal lymphomas of the large B-cell type. The application of array-based comparative genomic hybridization techniques attempts to identify genomic distinctions between PCNSL and nodal lymphomas and to identify the molecular markers that relate to prognosis. It is possible that insights gained from these studies will facilitate the development of targeted therapies, which address the fundamental genetic mutations that drive PCNSL and intraocular lymphoma growth.
Rubenstein
James L
JL
Division of Hematology/Oncology, University of California-San Francisco, Room M1282, Box 1270, San Francisco, CA 94143, USA. jamesr@medicine.ucsf.edu
Treseler
Patrick
P
O'Brien
Joan M
JM
D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000473:pathology; D005134:Eye Neoplasms / Q000235:genetics / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology