LIGHTing up dendritic cell activation: Immune regulation and viral exploitation.
The maturation state of dendritic cells (DC) is regulated by a variety of factors. These include ligands expressed by T cells, such as members of the TNF superfamily. Recent studies have highlighted the role of one such molecule, LIGHT, as a positive regulator of DC biology, promoting the maturation of these cells through the activation of NF-kappaB pathways. In addition, HSV-1 envelope glycoproteins can also bind the LIGHT receptor, herpes virus entry mediator (HVEM), and activate similar downstream signalling pathways in DC. The consequence of this host-viral interaction may be a novel pathway of viral immune evasion.
Pollara
Gabriele
G
Department of Immunology & Molecular Pathology, University College London, Windeyer Institute of Medical Sciences, London, United Kingdom. g.pollara@ucl.ac.uk
Katz
David R
DR
Chain
Benjamin M
BM
D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000378:metabolism*; D018139:Simplexvirus / Q000276:immunology*; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D008565:Membrane Proteins; C505914:TNFSF14 protein, human; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14; D014409:Tumor Necrosis Factor-alpha