Only a small proportion of anemia in northeast Thai schoolchildren is associated with iron deficiency.
BACKGROUND
Iron deficiency is assumed to be the major cause of anemia in northeast Thailand, but other factors may be involved.


OBJECTIVE
We determined the prevalence of anemia among schoolchildren in northeast Thailand and the role of hemoglobinopathies, selected micronutrient deficiencies, and other factors in hemoglobin status.


METHODS
Blood samples were collected from 567 children aged 6-12.9 y attending 10 primary schools for the determination of a complete blood count and hemoglobin type [Hb AA (normal hemoglobin), Hb AE (heterozygous for Hb type E), and Hb EE (homozygous for Hb type E)] and the measurement of serum ferritin, transferrin receptor, retinol, vitamin B-12, and plasma and erythrocyte folate concentrations. Children with a C-reactive protein concentration > or = 10 mg/L (n = 12), which indicated infection, were excluded.


RESULTS
The prevalence of anemia was 31%. Age, hemoglobin type, and serum retinol were the major predictors of hemoglobin concentration. Hb AA and Hb AE children with anemia had lower (P < 0.01) hematocrit, mean cell volume, and serum retinol values than did their nonanemic counterparts; no significant differences in serum ferritin were found by hemoglobin type. Only 16% (n = 22) of the anemic Hb AA and Hb AE children were iron deficient. Hb AA and Hb AE children with a serum retinol concentration <0.70 micromol/L (n = 14) had a significantly higher geometric mean serum ferritin concentration than did those with a retinol concentration > or = 0.70 micromol/L (P = 0.009); no significant difference in transferrin receptor concentrations was found between these 2 groups.


CONCLUSIONS
Hemoglobinopathies, suboptimal vitamin A status, and age were the major predictors of hemoglobin concentration. The contribution of iron deficiency to anemia was low, and its detection was complicated by coexisting suboptimal vitamin A status.
Thurlow
Rosanne A
RA
Institute of Nutrition, Mahidol University, Salaya, Thailand.
Winichagoon
Pattanee
P
Green
Timothy
T
Wasantwisut
Emorn
E
Pongcharoen
Tippawan
T
Bailey
Karl B
KB
Gibson
Rosalind S
RS
D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000453:epidemiology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005492:Folic Acid / Q000097:blood; D006304:Health Status; D006446:Hemoglobin E / Q000032:analysis; D006801:Humans; D000090463:Iron Deficiencies; D008297:Male; D013785:Thailand / Q000453:epidemiology; D014801:Vitamin A / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
D014801:Vitamin A; D006446:Hemoglobin E; D005492:Folic Acid; D014805:Vitamin B 12