title: Prevalence of anti-hepatits A antibodies in children of different socioeconomic conditions in Vila Velha, ES.
abstract: This report describes the prevalence of anti-HAV antibodies in children from elementary school in the Municipality of Vila Velha, ES, Brazil. Anti-HAV antibodies were investigated by ELISA method in the serum of 606 children (four to fourteen years old) from three elementary schools, located in neighborhoods with varying household monthly income levels: São José School, 200 children, household income higher than US$700; São Torquato School, 273 children, US$200 to 300; and Cobi School, 133 children, less than US$200. From each children data on age, gender, skin color, sanitary conditions, frequency of contact with sea or river water and family history of hepatitis were recorded. Anti-HAV antibodies were present in 38.6% of all children, 9% in São José School, 49.1% in São Torquato School and 61.7% in Cobi School. Logistic regression analysis demonstrated a positive correlation of positive anti-HAV test with age, non white color of the skin, absence of sewage treatment and domestic water filter, and a past history of hepatitis. The prevalence of anti-HAV antibodies in school children in Vila Velha, ES, was lower than that observed in the same age group in North and Northeast Brazil and was significantly higher in children from families with low socioeconomic status. In addition the results indicate a changing epidemiologic pattern of hepatitis A in our country, with an increasing number of children and adolescents with high risk for HAV infection, mainly in high socioeconomic class. A consideration must be given to the feasibility of vaccination programs for children and adolescents in our country.
authors.affiliation: Núcleo de Doenças Infecciosas, Centro Biomédico, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, 29040-091 Vitória, ES, Brazil.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Zago-Gomes
authors.forename: Gustavo C
authors.initials: GC
authors.lastname: Stantolin
authors.forename: Sandro
authors.initials: S
authors.lastname: Perazzio
authors.forename: Kioshi H
authors.initials: KH
authors.lastname: Aikawa
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Gonçalves
authors.forename: Fausto E L
authors.initials: FE
authors.lastname: Pereira
mesh_terms: D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006506:Hepatitis A / Q000175:diagnosis / Q000453:epidemiology; D035922:Hepatitis A Antibodies / Q000097:blood*; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006801:Humans; D007182:Income; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D014505:Urban Population
chemical_list: D035922:Hepatitis A Antibodies