title: Is there any correlation between stages of endometriosis and severity of chronic pelvic pain? Possibilities of treatment.
abstract: We report herein findings on 181 patients, suffering from pelvic endometriosis confirmed by histology, whose main symptom was chronic pelvic pain (CPP). They attended the outpatient clinic at the 1st Department of Obstetrics and Gynaecology, Semmelweis University in Budapest, between 1 January 1995 and 1 January 2000. The extent of pelvic endometriosis was determined on the basis of the 1985 revised scoring system of the American Fertility Society (R-AFS). The short form of the McGill pain questionnaire was used for the evaluation of CPP. After the first operative intervention, therapy with a gonadotropin-releasing hormone (GnRH) analog was given for 6 months. Second-look laparoscopy was performed 8-10 weeks after the end of GnRH-analog treatment, which was followed by a non-conventionally administered, monophasic oral contraceptive (OC) treatment. In the long term, 118 patients received the non-conventionally administered, monophasic OC treatment, which contained a third-generation progestogen, to be taken continuously for at least 6 months. The other 63 patients who did not receive OC treatment for one reason or another were evaluated as a control group. We analyzed data on CPP before the first surgical intervention, then following therapy with the GnRH analog at the second-look operation, and then after 6, 12, 18 and 24 months. We also reviewed potential causes of CPP, especially focused on endometriosis. No correlation was found between the stage of endometriosis according to R-AFS score and the severity of CPP. At the 24-month follow-up after second-look laparoscopy, the non-conventionally administered monophasic OC treatment was found not only to significantly reduce pain scores, but also the required radical operative solution (hysterectomy plus bilateral adnexectomy) for CPP by OC users.
authors.affiliation: 1st Department of Obstetrics and Gynaecology, Faculty of Medicine, Division of Endocrinology, Semmelweis University Budapest, H-1088 Budapest, Baross u.27, Hungary. szendei@noi1.sote.hu
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Szendei
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Hernádi
authors.forename: Nóra
authors.initials: N
authors.lastname: Dévényi
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Csapó
mesh_terms: D003131:Combined Modality Therapy; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004412:Dysmenorrhea / Q000188:drug therapy; D004414:Dyspareunia / Q000188:drug therapy; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D010147:Pain Measurement; D017699:Pelvic Pain / Q000145:classification / Q000209:etiology / Q000517:prevention & control*; D055502:Secondary Prevention
chemical_list: D003277:Contraceptives, Oral, Combined; D007987:Gonadotropin-Releasing Hormone