title: Cytokine recognition by human interleukin 5 receptor.
abstract: The activation of interleukin 5 (IL-5) receptor is a dynamic process that depends on specific interaction of IL-5 with IL-5 receptor alpha, the formation of oligomeric receptor complexes with receptor beta, and the initiation of cytoplasmic phosphorylation events. These steps culminate in the triggering of a cellular response. Important advances have been made recently in understanding the molecular mechanisms of cytokine recognition, receptor assembly, and signal triggering. Cytokine recognition can be envisioned by relating structure to function in IL-5 and IL-5 receptor alpha. A pair of charge-complementary regions plays an essential role in the specific interaction between IL-5 receptor alpha and IL-5. Moreover, peptide library methodology has led to the discovery of IL-5 receptor alpha antagonists that mimic key elements in IL-5 receptor recognition. Because IL-5 has been implicated in the pathology of eosinophil-related inflammatory diseases, revealing the key recognition elements of IL-5, IL-5 mimetic peptides, and IL-5 receptor alpha could help drive the design of new compounds for therapeutic treatment against allergic inflammatory diseases such as asthma.
authors.affiliation: Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishino
authors.forename: Noreen
authors.initials: N
authors.lastname: Robertson
authors.forename: Irwin
authors.initials: I
authors.lastname: Chaiken
mesh_terms: D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000737:chemistry; D016207:Cytokines / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D019281:Dimerization; D004220:Disulfides / Q000737:chemistry; D000939:Epitopes / Q000032:analysis / Q000737:chemistry; D006801:Humans; D015848:Interleukin-5 / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D053666:Interleukin-5 Receptor alpha Subunit; D008958:Models, Molecular; D019151:Peptide Library; D017433:Protein Structure, Secondary; D018123:Receptors, Interleukin / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D053649:Receptors, Interleukin-5; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D016207:Cytokines; D004220:Disulfides; D000939:Epitopes; C485918:IL5RA protein, human; D015848:Interleukin-5; D053666:Interleukin-5 Receptor alpha Subunit; D019151:Peptide Library; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5