A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.
Association analysis, based on linkage disequilibrium between specific alleles in the candidate loci and nearby genetic markers, has been proposed to identify genes conferring susceptibility to multifactorial diseases. Using the affected sib-pair method, we previously mapped four candidate chromosomal regions, 1p32, 2q33-q35, 11p13-p14, and 21q21, for gastric cancer by linkage analysis. To identify genes involved in the disease, we performed a gene-based association analysis of 66 genes, located on 21p11-21q22, using 126 single nucleotide polymorphisms (SNPs) as genetic markers in 373 patients with 250 controls. We found a significant association of five SNPs in the stress70 protein chaperon family member STCH gene with gastric cancer, especially with the non-cardia localization subgroup (P=0.0005-0.02, odds ratio=1.44-1.72). Comparisons of haplotype frequency showed significant association between TTGGC haplotype and gastric cancer (P=0.0001, odds ratio=1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease.
Aoki
Masayuki
M
Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Yamamoto
Ken
K
Ohyama
Shigekazu
S
Yamamura
Yoshitaka
Y
Takenoshita
Seiichi
S
Sugano
Kokichi
K
Minamoto
Toshinari
T
Kitajima
Masaki
M
Sugimura
Haruhiko
H
Shimada
Shinya
S
Noshiro
Hirokazu
H
Hiratsuka
Masahiro
M
Sairenji
Motonori
M
Ninomiya
Itasu
I
Yano
Masahiko
M
Uesaka
Katsuhiko
K
Matsuno
Seiki
S
Maehara
Yoshihiko
Y
Aikou
Takashi
T
Sasazuki
Takehiko
T
D000483:Alleles; D016022:Case-Control Studies; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007564:Japan; D018832:Molecular Chaperones / Q000235:genetics; D016017:Odds Ratio; D020411:Oligonucleotide Array Sequence Analysis; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*
D005819:Genetic Markers; D018840:HSP70 Heat-Shock Proteins; C086345:HSPA13 protein, human; D018832:Molecular Chaperones