Eudragit NE40-drug mixed coating system for controlling drug release of core pellets.
This study was aimed at developing a controlled-release coating system around core pellets with aqueous dispersion, along with some water channeling agents. Core pellets of diltiazem were prepared using the extrusion-spheronization technique and subsequently coated with aqueous dispersion of Eudragit NE40 alone, or drug-polymer mixtures using bottom-spray fluidized bed coater. The lag time in drug release profiles increased as the coating levels of Eudragit NE40 were increased, whereas no lag time was observed in core pellets coated with drug-polymer mixtures. Mixed coating at the 7% level exhibited comparatively better release profiles and provided desirable release rates during the 12-hour testing interval. Diltiazem HCl release from mixed coating was fairly independent of pH and drug loading. Curing of coated pellets was found to be an essential step for stable drug release profiles. The selection of core size range had remarkable effect on drug release rate and was considerably reduced by using greater core size.
Rahman
Nisar-Ur-
NU
Department of Pharmacy, Islamia University, Bahawalpur, Pakistan. Nisar60@yahoo.com
Yuen
K H
KH
D002121:Calcium Channel Blockers / Q000737:chemistry / Q000493:pharmacokinetics; D002482:Cellulose / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D004110:Diltiazem / Q000737:chemistry / Q000493:pharmacokinetics; D004343:Drug Implants / Q000737:chemistry / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D007785:Lactose / Q000737:chemistry / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010539:Permeability; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013997:Time Factors
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D004343:Drug Implants; C496967:Eudragit NE40D; D011109:Polymethacrylic Acids; D002482:Cellulose; D004110:Diltiazem; D007785:Lactose