1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.
A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A(1)AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A(2A)AR.
Manera
Clementina
C
Dipartimento di Scienze Farmaceutiche, via Bonanno 6, 56126 Pisa, Italy. manera@farm.unipi.it
Betti
Laura
L
Cavallini
Tiziana
T
Giannaccini
Gino
G
Martinelli
Adriano
A
Ortore
Gabriella
G
Saccomanni
Giuseppe
G
Trincavelli
Letizia
L
Tuccinardi
Tiziano
T
Ferrarini
Pier Luigi
PL
D000818:Animals; D002417:Cattle; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009287:Naphthyridines / Q000378:metabolism*; D043705:Receptor, Adenosine A2A / Q000378:metabolism*
D009287:Naphthyridines; D043705:Receptor, Adenosine A2A