title: Viral and cellular dynamics in HIV disease.
abstract: The control mechanisms that maintain a steady state viral load during chronic HIV-1 infection are critical to understanding the pathophysiology of HIV disease. The conceptual features of the two alternative models of viral control, referred to in this article as target cell limitation and immune control, are compared to the data regarding the viral and cellular dynamics of HIV-1 infection and the pattern of changes induced by effective antiretroviral drug therapy. The available data support the model that an antigen-driven immune response is the primary mechanism that limits viral growth in vivo.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, P220 West Pavilion, 619 South 19th Street, Birmingham, AL 35233, USA. bucy@path.uab.edu
authors.forename: R Pat
authors.initials: RP
authors.lastname: Bucy
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1; D006801:Humans; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents