Investigations on some pharmacological properties of TPP.
The experiments were performed on mice, rats and rabbits. The influence on circulatory, central nervous, and gastrointestinal system in vivo and in vitro, as well as on renal secretory activity was examined. TPP was administered p.o., i.v. and s.c. at the doses 100.0-400.0 mg/kg. Either in a single dose or multiple doses TPP did not evoke any significant effects (as compared with NaCl solution) on blood pressure, heart and respiratory rate, general behaviour, locomotor activity, body temperature, locomotor coordination, ECoG, smooth muscles of intestine in vivo and in vitro, gastric secretion and on the volume and quality of excreted urine. The augmentation of sodium and potassium ion excretion with urine and slight influence on locomotor coordination both after TPP and 6% NaCl seems to be connected with a high content of salt in TPP.
Filczewski
M
M
Department of Pharmacology, Pharmaceutical Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Kosmala
M
M
Oledzka
K
K
Bogdal
M
M
Szafrański
B
B
Małecki
I
I
Borkowska
B
B
Przemyk
B
B
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002241:Carbohydrates / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D041981:Gastrointestinal Tract / Q000187:drug effects; D006812:Humic Substances; D007668:Kidney / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects; D014574:Uronic Acids / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; C084029:Tolpa; D014574:Uronic Acids