Effectiveness of antiinfectives.
BACKGROUND
Helicobacter pylori is one of the most common infections of mankind, with persistent colonization causing significant morbidity and mortality.


METHODS
First-line therapy, consisting of 7-day treatment with a proton pump inhibitor or ranitidine bismuth citrate, amoxicillin and clarithromycin, with second-line therapy, consisting of a proton pump inhibitor, bismuth, metronidazole, and tetracycline, in the case of failure, is chosen as the most cost-effective method of H. pylori eradication.


CONCLUSIONS
The effectiveness of these antiinfectives is limited by lack of compliance with treatment regimens, and increasing antibiotic resistance.
McLoughlin
Ramona
R
Adelaide and Meath Hospital, and Trinity College, Dublin, Ireland.
O'Morain
Colm
C
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000188:drug therapy*; D006801:Humans; D010349:Patient Compliance; D054328:Proton Pump Inhibitors; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors