title: White matter hyperintensities as a predictor of neuropsychological deficits post-stroke.
abstract: OBJECTIVE
  Cerebral white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) are a recognised risk factor for post-stroke dementia. Their specific relations to cognitive impairment are still not well known. The purpose of this study was to explore how the severity and location of WMHs predict neuropsychological test performance in the context of other brain lesions in elderly stroke patients.
  
  
  METHODS
  In the Helsinki Stroke Aging Memory Study, 323 patients, aged from 55 to 85 years, completed a detailed neuropsychological test battery and MRI 3 months after an ischaemic stroke. The demographic and MRI predictors of cognition were studied with sequential linear regression analyses.
  
  
  RESULTS
  After age, education and total infarct volume were controlled for, the overall degree of WMHs predicted poor performance in tests of mental speed, executive functions, memory, and visuospatial functions, but not in those of short term memory storage or verbal conceptualisation. However, the contribution of separate white matter regions was relatively low. Only the lesions along the bodies of lateral ventricles were independently associated with speed and executive measures. Additionally, general cortical atrophy clearly predicted a wide range of cognitive deficits while infarct volume had less relevance. Further analyses revealed that executive functions act as a strong mediator between the relationship of WMHs to memory and visuospatial functions.
  
  
  CONCLUSIONS
  The degree of WMHs is independently related to post-stroke cognitive decline. The most affected cognitive domains seem to be executive functions and speed of mental processing, which may lead to secondary deficits of memory and visuospatial functions.
authors.affiliation: Department of Neurology, Helsinki University Central Hospital, P.O. Box 302, FIN-00029 HUS, Helsinki, Finland. hanna.jokinen@helsinki.fi
authors.forename: H
authors.initials: H
authors.lastname: Jokinen
authors.forename: H
authors.initials: H
authors.lastname: Kalska
authors.forename: R
authors.initials: R
authors.lastname: Mäntylä
authors.forename: R
authors.initials: R
authors.lastname: Ylikoski
authors.forename: M
authors.initials: M
authors.lastname: Hietanen
authors.forename: T
authors.initials: T
authors.lastname: Pohjasvaara
authors.forename: M
authors.initials: M
authors.lastname: Kaste
authors.forename: T
authors.initials: T
authors.lastname: Erkinjuntti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011379:Prognosis; D012044:Regression Analysis; D013028:Space Perception; D020521:Stroke / Q000473:pathology*; D014796:Visual Perception