title: Multiplex approaches in protein microarray technology.
abstract: The success of genome sequencing projects has provided the basis for systematic analysis of protein function and has led to a shift from the description of single molecules to the characterization of complex samples. Such a task would not be possible without the provision of appropriate high-throughput technologies, such as protein microarray technology. In addition, the increasing number of samples necessitates the adaptation of such technologies to a multiplex format. This review will discuss protein microarray technology in the context of multiplex analysis and highlight its current prospects and limitations.
authors.affiliation: Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, D-13125 Berlin-Buch, Germany. b.kersten@mdc-berlin.de
authors.forename: Birgit
authors.initials: B
authors.lastname: Kersten
authors.forename: Erich E
authors.initials: EE
authors.lastname: Wanker
authors.forename: Jörg D
authors.initials: JD
authors.lastname: Hoheisel
authors.forename: Philipp
authors.initials: P
authors.lastname: Angenendt
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics; D006801:Humans; D007118:Immunoassay; D020411:Oligonucleotide Array Sequence Analysis; D040081:Protein Array Analysis / Q000295:instrumentation* / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D011506:Proteins; D004247:DNA