title: Role of the AZFd locus in spermatogenesis.
abstract: To determine the prevalence of Y-chromosome microdeletions among infertile men and to correlate the clinical presentation of the men with specific deletions, microdeletion analysis in 53 infertile men (30 nonobstructive azoospermic, 23 severely oligozoospermic patients), and 100 age-matched, fathered normospermic men who had fathered children was performed by the multiplex PCR with 18 different Y-chromosome-specific STS primer sets, spanning the AZFa, AZFb, AZFd, and AZFc regions. Detection of the same locus deletion of the AZFd region in three cases indicated the possible importance of the genes located in this region in spermatogenesis.
authors.affiliation: Department of Medical Genetics, Osmangazi University Medical Faculty, Meşelik, Eskişehir, Turkey.
authors.forename: Muhammed Hamza
authors.initials: MH
authors.lastname: Müslümanoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Turgut
authors.forename: Oguz
authors.initials: O
authors.lastname: Cilingir
authors.forename: Cavit
authors.initials: C
authors.lastname: Can
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ozyürek
authors.forename: Sevilhan
authors.initials: S
authors.lastname: Artan
mesh_terms: D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D056426:Genetic Loci; D005819:Genetic Markers / Q000502:physiology; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000453:epidemiology / Q000235:genetics; D015995:Prevalence; D029589:Seminal Plasma Proteins / Q000235:genetics / Q000502:physiology*; D013091:Spermatogenesis / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D029589:Seminal Plasma Proteins