GPCR modulation by RAMPs.
Our conceptual understanding of the molecular architecture of G-protein coupled receptors (GPCRs) has transformed over the last decade. Once considered as largely independent functional units (aside from their interaction with the G-protein itself), it is now clear that a single GPCR is but part of a multifaceted signaling complex, each component providing an additional layer of sophistication. Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function. They act as pharmacological switches, modifying GPCR pharmacology for a particular subset of receptors. However, there is accumulating evidence that these ubiquitous proteins have a broader role, regulating signaling and receptor trafficking. This article aims to provide the reader with a comprehensive appraisal of RAMP literature and perhaps some insight into the impact that their discovery has had on those who study GPCRs.
Hay
Debbie L
DL
School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand.
Poyner
David R
DR
Sexton
Patrick M
PM
D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D058261:Receptor Activity-Modifying Proteins; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D058261:Receptor Activity-Modifying Proteins; D043562:Receptors, G-Protein-Coupled