title: Rubella-associated hemophagocytic syndrome in an infant.
abstract: Hemophagocytic syndrome (HPS) is a fulminant disorder characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes in the lymphoreticular tissues. The characteristic pathologic feature is reactive histiocytic hyperplasia with leukoerythrophagocytosis in a variety of organs. This disorder occurs most often in patients in whom the immune system is compromised and has been associated with a variety of infectious agents, including viruses, bacteria, mycobacteria, spirochetes, fungi, and parasites. The authors describe a 2.5-month-old girl with rubella-associated HPS, demonstrated by postmortem liver necropsy.
authors.affiliation: Department of Pediatrics, Division of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey. abaykan@erciyes.edu.tr
authors.forename: Ali
authors.initials: A
authors.lastname: Baykan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakus
authors.forename: Kemal
authors.initials: K
authors.lastname: Deniz
mesh_terms: D001344:Autopsy; D017809:Fatal Outcome; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D012409:Rubella / Q000150:complications*