Individual changes in lamotrigine plasma concentrations during pregnancy.
Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.
Petrenaite
Vaiva
V
Department of Clinical Neurophysiology 3063, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. vaiva@ofir.dk
Sabers
Anne
A
Hansen-Schwartz
Jacob
J
D000328:Adult; D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D049590:Postpartum Period / Q000097:blood / Q000187:drug effects; D011247:Pregnancy / Q000097:blood* / Q000187:drug effects; D012189:Retrospective Studies; D014227:Triazines / Q000097:blood* / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine