Dopaminergic effects on encoding of a motor memory in chronic stroke.
The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relative to placebo. Up-regulation of dopaminergic function may enhance motor memory formation, crucial for successful rehabilitative treatments in patients with chronic stroke.
Floel
A
A
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20817, USA.
Hummel
F
F
Breitenstein
C
C
Knecht
S
S
Cohen
L G
LG
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002908:Chronic Disease; D018592:Cross-Over Studies; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects / Q000502:physiology; D009068:Movement / Q000187:drug effects / Q000502:physiology; D009069:Movement Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D010291:Paresis / Q000188:drug therapy / Q000503:physiopathology; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology; D013933:Thumb / Q000294:innervation / Q000503:physiopathology; D016896:Treatment Outcome
D015259:Dopamine Agents; D007980:Levodopa; D004298:Dopamine