title: Is mammographic density, as currently measured, a robust surrogate marker for breast cancer?
abstract: In order to determine current beliefs concerning the relevance of breast mammographic percent density (MPD) as a surrogate marker for breast cancer, the panel and the delegates completed a questionnaire. There was general agreement between the panel and delegates on most aspects, although the delegates were unsure whether high breast MPD is a contraindication for hormone therapy and tended to err on the side of caution in suggesting that estrogen and estrogen/progestogen therapy should be stopped before screening mammography. The overall consensus of the panel and the delegates was that breast MPD should become an important clinical tool, and that carefully designed studies are needed to determine exactly how it can be best used to guide clinical decision-making.
authors.affiliation: Imaging Research, Sunnybrook and Women's Health Sciences Centre, University of Toronto, Toronto, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Yaffe
authors.forename: Susan
authors.initials: S
authors.lastname: Hendrix
authors.forename: Malcolm
authors.initials: M
authors.lastname: Pike
authors.forename: Richard
authors.initials: R
authors.lastname: Santen
authors.forename: John
authors.initials: J
authors.lastname: Eden
authors.forename: Ar
authors.initials: A
authors.lastname: Genazzani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001940:Breast / Q000187:drug effects* / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology; D000075202:Contraindications; D020847:Estrogen Receptor Modulators / Q000494:pharmacology; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D009652:Norpregnenes / Q000494:pharmacology; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D020847:Estrogen Receptor Modulators; D009652:Norpregnenes; C027385:tibolone