[Synthesis of 4,4-substituted-5,5-mercapto-3,3'-bi-1,2,4-triazole and 2,2'-amino-substituted-5,5-bi-1,3,4-thiodiazole].
In reaction of oxalic acid dihydrazide with isothiocyanates were obtained the respective thiosemicarbaside derivatives (Ia-IXa). Their cyclization in alkaline media have given the corresponding 4,4'-substituted-5,5'-mercapto-3,3'-bi-1,2,4-triazole (Ib-IXb), in acidic media however were formed the 2,2'-amino-substituted-5,5'-bi-1,3,4-thiodiazole (Ic-VIIIc).
Dobosz
M
M
Zakład Chemii Organicznej, Wydział Farmaceutyczny, Akademia Medyczna, ul. Staszica 6, 20-081 Lublin.
Rekas
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J
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D013830:Thiadiazoles; D014230:Triazoles