title: Enantioselective Brønsted acid catalyzed transfer hydrogenation: organocatalytic reduction of imines.
abstract: The first enantioselective Brønsted acid catalyzed reduction of imines has been developed. This new organocatalytic transfer hydrogenation of ketimines with Hantzsch dihydropyridine as the hydrogen source offers a mild method to various chiral amines with high enantioselectivity. The stereochemistry of the chiral amines can be rationalized by a stereochemical model derived from an X-ray crystal structure of a chiral BINOL phosphate catalyst. [reaction: see text]
authors.affiliation: Institute of Chemistry and Chemical Biology, Johann-Wolfgang Goethe University Frankfurt am Main, Marie-Curie-Strasse 11, D-60439 Frankfurt, Germany. m.rueping@chemie.uni-frankfurt.de
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
authors.forename: Erli
authors.initials: E
authors.lastname: Sugiono
authors.forename: Cengiz
authors.initials: C
authors.lastname: Azap
authors.forename: Thomas
authors.initials: T
authors.lastname: Theissmann
authors.forename: Michael
authors.initials: M
authors.lastname: Bolte