Receptors, rafts, and microvesicles in thrombosis and inflammation.
Hemostasis at sites of blood vessel injury and its pathologic counterpart, thrombosis, involve a complex interplay between several blood elements: soluble proteins of the blood coagulation system, blood cells (most prominently platelets) and cell fragments, and elements of the vessel wall (endothelial cells and, at sites of injury, the exposed matrix and deeper cellular components). In this review, we focus on ways in which specialized membrane microdomains known as lipid rafts are involved in various phases of hemostasis and thrombosis.
López
J A
JA
Baylor College of Medicine, Thrombosis Research Section, Houston, TX 77030, USA. josel@bcm.tmc.edu
del Conde
I
I
Shrimpton
C N
CN
D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D021962:Membrane Microdomains / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D015539:Platelet Activation; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000502:physiology; D013927:Thrombosis / Q000473:pathology*
D019038:Platelet Glycoprotein GPIb-IX Complex