title: Different modes of weight loss in Alzheimer disease: a prospective study of 395 patients.
abstract: BACKGROUND
  Alzheimer disease is often accompanied and worsened by malnutrition. Patterns of weight loss can differ by the patients concerned and by the outcome and interventions required.
  
  
  OBJECTIVE
  Our aim was to describe and analyze 2 modes of weight loss (progressive and severe) in the course of Alzheimer disease.
  
  
  METHODS
  This was a prospective study of 395 patients with Alzheimer disease, who had a mean age of 75.4 y. A standardized gerontologic evaluation was conducted at 6 mo and 1 y, including assessments of nutrition, neuropsychology, function, and caregiver burden.
  
  
  RESULTS
  We investigated 2 modes of weight loss. The first, progressive loss (4% in 1 y), affected 33.4% of subjects. Disease severity was a risk factor [odds ratio (OR): 7.2; 95% CI: 1.4, 38.2 for a Reisberg score > or = 5], whereas treatment with cholinesterase inhibitors at baseline decreased this risk (OR: 0.33; 95% CI: 0.14, 0.79). The second mode of weight loss, a severe loss of > or =5 kg in 6 mo, affected 10.2% of subjects. The existence of an acute phase reaction was a risk factor (OR: 2.4; 95% CI: 1.2, 4.8), as was an intercurrent event, such as hospitalization, acute disease, institutionalization, and change of living arrangements (OR: 6.8; 95% CI: 1.2, 39.9).
  
  
  CONCLUSIONS
  During the follow-up of patients with Alzheimer disease, risk factors for these 2 modes of weight loss should be sought to identify patients who would benefit from a nutritional intervention. Our findings lead us to advocate follow-up, which involves an assessment of functional, nutritional, and neuropsychologic status every 6 mo.
authors.affiliation: Department of Gerontology, University Hospital, Nice, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Guérin
authors.forename: Sandrine
authors.initials: S
authors.lastname: Andrieu
authors.forename: Stéphane M
authors.initials: SM
authors.lastname: Schneider
authors.forename: Morgan
authors.initials: M
authors.lastname: Milano
authors.forename: Rabia
authors.initials: R
authors.lastname: Boulahssass
authors.forename: Patrice
authors.initials: P
authors.lastname: Brocker
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D015431:Weight Loss