2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines.
2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed allylic substitution using 1,3-dimethylbarbituric acid as a nucleophile.
Gommermann
Nina
N
Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandstrasse 5-13, Haus F, D-81377 München, Germany.
Knochel
Paul
P