Polyneuropathy associated with interferon beta treatment in patients with multiple sclerosis.
Peripheral neuropathy has been reported as a side effect of interferon alpha, but not with interferon beta (IFNbeta) treatment. The authors assessed six patients with multiple sclerosis who developed polyneuropathy, or had exacerbation of previously subclinical neuropathy, during treatment with IFNbeta. In five patients the neuropathy improved after discontinuation of treatment and in two patients it relapsed upon rechallenge.
Ekstein
Dana
D
Department of Neurology, The Agnes Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Karem, Jerusalem, Israel. dekstein@md.huji.ac.il
Linetsky
Eduard
E
Abramsky
Oded
O
Karussis
Dimitrios
D
D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology; D009431:Neural Conduction / Q000187:drug effects / Q000276:immunology; D010291:Paresis / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000187:drug effects* / Q000276:immunology / Q000503:physiopathology; D011115:Polyneuropathies / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D012008:Recurrence; D012678:Sensation Disorders / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology
D000068576:Interferon beta-1b; D016899:Interferon-beta; D000068556:Interferon beta-1a