V-shaped, longitudinal nail dystrophies in trichorhinophalangeal syndrome type I.
Trichorhinophalangeal syndrome (TRPS) is a rare genodermatosis with growth retardation, craniofacial abnormalities, alopecia and brachyphalangia. Three subtypes with considerable clinical overlap can be separated. Numerous nail changes have been documented in this syndrome. We observed a 19-year-old female with typical TRPS I who developed unique V-shaped longitudinal nail dystrophies on both hands. TRPS belongs to the spectrum of ectodermal dysplasias, and therefore it is not surprising that cutaneous adnexal structures are involved in different ways.
Itin
Peter H
PH
Department of Dermatology, University Hospital Basel, Basel, Switzerland. peter.itin@unibas.ch
Eich
Georg
G
Fistarol
Susanna K
SK
D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000235:genetics; D000287:Administration, Topical; D000328:Adult; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015826:Langer-Giedion Syndrome / Q000175:diagnosis*; D009260:Nail Diseases / Q000151:congenital / Q000175:diagnosis* / Q000188:drug therapy; D009264:Nails, Malformed; D016896:Treatment Outcome
D003879:Dermatologic Agents