title: Milk amyloid A: correlation with cellular indices of mammary inflammation in cows with normal and raised serum amyloid A.
abstract: This study compared concentrations of amyloid A in bovine milk with the cell-based indicators of intramammary inflammation, somatic cell count and California Mastitis Test. Mammary quarter data pertaining to 180 cows were categorised according to concentrations of serum amyloid A in the cow of origin. Ranked correlation, ranked regression and receiver operator characteristics all demonstrated acceptable agreement between milk amyloid A concentrations and cell-based indices. There were some indications of reduction in this agreement, in cows with raised concentrations of serum amyloid A. However, there were also indications that serum amyloid A did not significantly influence milk amyloid A. The results of the current study indicate that milk amyloid A exhibits good correlation with established cell-based indicators of intramammary inflammation.
authors.affiliation: Department of Large Animal Clinical Studies, Faculty of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Michael.OMahony@ucd.ie
authors.forename: M C
authors.initials: MC
authors.lastname: O'Mahony
authors.forename: A M
authors.initials: AM
authors.lastname: Healy
authors.forename: D
authors.initials: D
authors.lastname: Harte
authors.forename: K G
authors.initials: KG
authors.lastname: Walshe
authors.forename: P R
authors.initials: PR
authors.lastname: Torgerson
authors.forename: M L
authors.initials: ML
authors.lastname: Doherty
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002417:Cattle; D005260:Female; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D008321:Mammary Glands, Animal / Q000473:pathology*; D008414:Mastitis, Bovine / Q000097:blood* / Q000175:diagnosis / Q000473:pathology*; D008892:Milk / Q000737:chemistry*; D012680:Sensitivity and Specificity; D000685:Serum Amyloid A Protein / Q000032:analysis*
chemical_list: D015415:Biomarkers; D000685:Serum Amyloid A Protein