title: An enantioselective entry to cis-perhydroisoquinolines.
abstract: An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position. [reaction: see text]
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Amat
authors.forename: Maria
authors.initials: M
authors.lastname: Pérez
authors.forename: Annamaria T
authors.initials: AT
authors.lastname: Minaglia
authors.forename: Núria
authors.initials: N
authors.lastname: Casamitjana
authors.forename: Joan
authors.initials: J
authors.lastname: Bosch