Epigenetic silencing in embryogenesis.
Transcription profiling of early embryos emphasizes that differential gene expression is a fundamental control mechanism of development. Precise regulatory mechanisms operate on a background of epigenetic changes in chromatin composition, modification, and architecture that are integral for the development of a pluripotent embryo into an adult.
Meehan
Richard R
RR
Human Genome Unit, Medical Research Council, Western General Hospital, Crewe Road, Edinburgh EH4 9XU, UK. r.meehan@hgu.mrc.ac.uk
Dunican
Donncha S
DS
Ruzov
Alexey
A
Pennings
Sari
S
D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000502:physiology*; D020868:Gene Silencing / Q000502:physiology*; D006801:Humans