title: Movement time and aging: a normative study in healthy subjects with the "Movement Time Analyzer".
abstract: OBJECTIVE
  Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders characterized by bradykinesia, tremor at rest, and rigidity. Movement Time (MT) has been investigated in PD to evaluate bradykinesia and its levodopa-induced modifications. The Movement Time Analyzer (MTA) is a simple, objective and reliable instrument to study MT, but no normative study has been reported to date.
  
  
  METHODS
  In a sample of normal subjects (n = 68), we studied MT detected by MTA in order to assess normative values, so that the MTA could be used to evaluate patients with PD in daily clinical practice.
  
  
  RESULTS
  In normal subjects, MT progressively increased with aging, and was slower on the non-dominant side than on the dominant side. No differences were found between men or women.
  
  
  CONCLUSIONS
  Our data provide further information about normative values on MT detected by MTA, and indicate that age and handedness are the main variables influencing motor task performance.
authors.affiliation: Institute of Neurology, University Magna Graecia, Catanzaro, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicoletti
authors.forename: Gennarina
authors.initials: G
authors.lastname: Arabia
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Pugliese
authors.forename: Giusi
authors.initials: G
authors.lastname: Torchia
authors.forename: Franco
authors.initials: F
authors.lastname: Pucci
authors.forename: Antonio
authors.initials: A
authors.lastname: Gambardella
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
authors.forename: Mario
authors.initials: M
authors.lastname: Zappia
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D018476:Hypokinesia / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D009142:Musculoskeletal Physiological Phenomena; D010300:Parkinson Disease / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology*; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013997:Time Factors