Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone.
The antiplatelet activities of Curcuma longa L. rhizome-derived materials were measured using a platelet aggregometer and compared with those of aspirin as antiplatelet agent. The active constituent from the rhizome of Curcuma longa L. was isolated and characterized as ar-turmerone by various spectral analyses. At 50% inhibitory concentration (IC50) value, ar-turmerone was effective in inhibiting platelet aggregation induced by collagen (IC50, 14.4 microM) and arachidonic acid (IC50, 43.6 microM). However, ar-turmerone had no effect on platelet activating factor or thrombin induced platelet aggregation. In comparison, ar-turmerone was significantly more potent platelet inhibitor than aspirin against platelet aggregation induced by collagen. These results suggested that ar-turmerone could be useful as a lead compound for inhibiting platelet aggregation induced by collagen and arachidonic acid.
Lee
H S
HS
Faculty of Applied Biotechnology, Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University, Chonju 561-756, Republic of Korea. hoiseon@chonbuk.ac.kr
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001241:Aspirin / Q000737:chemistry; D001792:Blood Platelets / Q000187:drug effects; D003094:Collagen / Q000737:chemistry; D030024:Curcuma / Q000378:metabolism*; D006586:Hexanes / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007659:Ketones / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D027343:Rhizome / Q000378:metabolism*; D012717:Sesquiterpenes; D014050:Toluene / Q000031:analogs & derivatives* / Q000494:pharmacology
D006586:Hexanes; D007659:Ketones; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D012717:Sesquiterpenes; C078098:ar-turmerone; D016718:Arachidonic Acid; D014050:Toluene; D003094:Collagen; D001241:Aspirin