title: Intermittent individual housing increases survival of newly proliferated cells.
abstract: In this study, we analyzed how intermittent individual housing with or without a running wheel influenced corticosterone levels and survival of newly proliferated cells in the dentate gyrus of the hippocampus. Female Balb/c mice, in standard or enhanced housing, were divided into groups that were individually housed with or without running wheels on every second day. Intermittent individual housing without, but not with, running wheels increased survival of proliferated cells in the dentate gyrus as compared with continuous group housing in standard or enhanced conditions. Thus, changes in housing conditions on every second day can, under certain circumstances, have an impact on the survival of newly proliferated cells in the dentate gyrus.
authors.affiliation: Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Elin
authors.initials: E
authors.lastname: Aberg
authors.forename: Therese M
authors.initials: TM
authors.lastname: Pham
authors.forename: Mieke
authors.initials: M
authors.lastname: Zwart
authors.forename: Vera
authors.initials: V
authors.lastname: Baumans
authors.forename: Stefan
authors.initials: S
authors.lastname: Brené
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D018891:Dentate Gyrus / Q000166:cytology* / Q000502:physiology*; D004779:Environment Design; D005260:Female; D006799:Housing, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010805:Physical Conditioning, Animal
chemical_list: D001973:Bromodeoxyuridine; D003345:Corticosterone