title: Do clinical variables predict an abnormal EEG in patients with complex febrile seizures?
abstract: OBJECTIVE
  Febrile seizures are the commonest convulsive event in children younger than 5 years of age (incidence of 2-5%). Electroencephalography (EEG) is not indicated in the work up of simple febrile seizures. Information about its role in the assessment of complex febrile seizures (CFSs) is unclear and EEGs are frequently ordered. This study was designed to assess utility of clinical variables at presentation in predicting the likelihood of an abnormal EEG.
  
  
  METHODS
  EEG requisitions, EEG reports, clinic charts and medical records over an 11-year period (1990--2001) were retrospectively reviewed. The relationship between clinical variables like age, timing of the EEG since CFS, family history of seizures, neurological assessment and EEG abnormalities was statistically analyzed.
  
  
  RESULTS
  One hundred and seventy-five children were included in the study. Of these 39.43% had EEG abnormalities. Children with a normal EEG were younger than those with an abnormal EEG (mean age 15.72 months versus 19.75 months, p<0.05). Using multivariate analysis, factors predictive of abnormal EEGs in children with CFS were; age >3 years (p=0.010; 95% CI: 1.5--18.8), EEGs performed within 7 days (p=0.00; 95% CI: 1.78--7.12) and an abnormal neurological exam (p=0.053; 95% CI: 0.98--16.9). A family history of febrile seizures was more likely to be associated with a normal EEG (p=0.01; 95% CI: 0.04--0.60).
  
  
  CONCLUSIONS
  Clinical variables at presentation can be used to screen children with CFS for whom an EEG is considered. This may lead to better use of resources. Whether abnormal EEG translates to future recurrences or epilepsy needs a prospective study.
authors.affiliation: Section of Pediatric Neurosciences, Department of Pediatrics, Children's Hospital, Health Sciences Centre, University of Manitoba, Manitoba, Canada R3A 1S1. cjoshi@hsc.mb.ca
authors.forename: Charuta
authors.initials: C
authors.lastname: Joshi
authors.forename: Teresa
authors.initials: T
authors.lastname: Wawrykow
authors.forename: Jill
authors.initials: J
authors.lastname: Patrick
authors.forename: Asuri
authors.initials: A
authors.lastname: Prasad
mesh_terms: D002675:Child, Preschool; D004569:Electroencephalography; D005190:Family; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D003294:Seizures, Febrile / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*