Samarium-promoted coupling of pyridine-based heteroaryl analogues of benzylic acetates with carbonyl compounds.
2-Substituted pyridine, quinoline, isoquinoline, bipyridine, and 1,10-phenanthroline analogues of benzylic acetates undergo SmI(2)-promoted coupling with aldehydes and ketones to afford (2-hydroxyalkyl)heteroaromatics. [reaction: see text]
Weitgenant
Jeremy A
JA
Department of Chemistry and Biochemistry and Walther Cancer Research Center, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
Mortison
Jonathan D
JD
Helquist
Paul
P