Pentaerythritol as the core of multivalent glycolipids: synthesis of a glycolipid with three SO3Lea ligands.
A glycolipid containing three SO(3)Le(a) ligands was synthesized with pentaerythritol as the core. The glycolipid was used to prepare glycoliposomes that showed stability similar to that of DSPC liposomes without glycolipid. The easily prepared derivatives of pentaerythritol proved to be useful scaffolds for multivalent displaying of carbohydrates in the form of glycolipids and clustered glycoliposomes. [structure: see text]
Xue
Jie
J
Departments of Chemistry and Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7078, USA.
Zhu
Junmin
J
Marchant
Roger E
RE
Guo
Zhongwu
Z
D002240:Carbohydrate Sequence; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry*; D007983:Lewis Blood Group Antigens / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D011409:Propylene Glycols / Q000737:chemistry*
D006017:Glycolipids; D007983:Lewis Blood Group Antigens; D008024:Ligands; D011409:Propylene Glycols; C008783:pentaerythritol