title: [Obsessive-compulsive symptoms treatment in: schizophrenia].
abstract: Obsessive-compulsive symptoms (OCSs) frequently occur in schizophrenia and seem to worsen prognosis. Many case studies suggest that OCSs appear or worsen with an atypical antipsychotic agent treatment (that is, with risperidone, olanzapine, and clozapine). Therefore, family or personal history of OCS should be investigated before initiating such treatment, and OCS onset should be monitored during treatment. Clozapine is involved in most such cases. When OCSs appear with clozapine, dosage can be reduced and a serotonin reuptake inhibitor treatment added. Current studies suggest that patients with schizophrenia and OCSs should benefit from treatment with an antipsychotic and an antiobsessive medication. Two controlled trials deal with OCS treatment in schizophrenia: the first, with clomipramine; and the second, with fluvoxamine. Both have proven their efficacy, but these trials include a small number of patients with heterogeneous characteristics.
authors.affiliation: Association de Santé Mentale du 13e arrondissement, Policlinique Wurtz, Paris.
authors.forename: Sophie
authors.initials: S
authors.lastname: Faucher
authors.forename: Roland
authors.initials: R
authors.lastname: Dardennes
authors.forename: Olivier
authors.initials: O
authors.lastname: Ghaëm
authors.forename: Julien-Daniel
authors.initials: JD
authors.lastname: Guelfi
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000453:epidemiology* / Q000523:psychology; D000077152:Olanzapine; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000453:epidemiology*; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine