New wrinkles and folds in site-specific recombination.
The new work of reveals a new site-specific recombination strategy to establish lysogeny, in which a double-stranded recombination substrate is assembled from the folded single-stranded DNA genome of the filamentous Vibrio cholerae phage CTXphi. This strategy allows the phage to use the host's recombinases while at the same time preventing inappropriate excision of the prophage.
Segall
Anca M
AM
Center for Microbial Sciences and The Department of Biology, San Diego State University, San Diego, California 92182, USA.
Craig
Nancy L
NL
D001435:Bacteriophages / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology; D019426:Integrases / Q000235:genetics / Q000502:physiology; D045522:Recombinases / Q000235:genetics*; D011995:Recombination, Genetic; D014734:Vibrio cholerae / Q000235:genetics / Q000821:virology*
D029968:Escherichia coli Proteins; D045522:Recombinases; C473360:XerC protein, E coli; D019426:Integrases; C473361:XerD protein, E coli