title: Effects of long-term continuous exposure to light on memory and anxiety in mice.
abstract: The studies on the relationship between the light/dark cycle and memory function mostly used protocols of acute disruption of the circadian rhythm. The aim of the present study is to verify the effects of long-term continuous exposure to light on memory, anxiety and motor parameters of mice tested in the plus-maze discriminative avoidance task. Mice were conditioned to choose between the two enclosed arms (one aversive and one non-aversive) while avoiding the open arms of a modified elevated plus-maze apparatus. Memory was evaluated by the time spent in the aversive enclosed arm, anxiety was evaluated by the time spent in the open arms and locomotor behavior was evaluated by number of entries in the arms of the maze. The results showed that long-term (35-42 days) continuous light exposure did not modify memory or anxiety parameters but increased locomotor activity. While the increase in locomotor behavior is in line with previous studies, the unexpected absence of alterations in memory and anxiety (reported to be influenced by the circadian rhythm) is discussed.
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, Brazil.
authors.forename: J P M V
authors.initials: JP
authors.lastname: Castro
authors.forename: R
authors.initials: R
authors.lastname: Frussa-Filho
authors.forename: D F
authors.initials: DF
authors.lastname: Fukushiro
authors.forename: C C
authors.initials: CC
authors.lastname: Chinen
authors.forename: V C
authors.initials: VC
authors.lastname: Abílio
authors.forename: R H
authors.initials: RH
authors.lastname: Silva
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000628:therapy*; D001362:Avoidance Learning / Q000528:radiation effects; D001522:Behavior, Animal; D004193:Discrimination Learning / Q000528:radiation effects; D008027:Light; D008297:Male; D018782:Maze Learning / Q000528:radiation effects; D008568:Memory / Q000502:physiology / Q000528:radiation effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010789:Phototherapy; D013997:Time Factors