title: Nuclear inositol lipid metabolism: more than just second messenger generation?
abstract: A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-beta1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
authors.affiliation: Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia Umana, Cell Signalling Laboratory, Università di Bologna, 40126 Bologna, Italy.
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Martelli
authors.forename: Matilde Yung
authors.initials: MY
authors.lastname: Follo
authors.forename: Camilla
authors.initials: C
authors.lastname: Evangelisti
authors.forename: Federica
authors.initials: F
authors.lastname: Falà
authors.forename: Roberta
authors.initials: R
authors.lastname: Fiume
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Billi
authors.forename: Lucio
authors.initials: L
authors.lastname: Cocco
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D050356:Lipid Metabolism; D054799:Phospholipase C beta; D015290:Second Messenger Systems; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D002843:Chromatin; D007527:Isoenzymes; D007294:Inositol; D010738:Type C Phospholipases; C518033:PLCB1 protein, human; D054799:Phospholipase C beta