An array of genes implicated in Alzheimer's disease.
Studying altered gene expression patterns in Alzheimer's disease may be helpful for identifying novel therapeutic targets and for elucidating key cellular processes that are involved in the neurodegenerative phenotype. To date, the advances that have emerged from these types of studies have been limited, largely confirming prevailing hypotheses and pathways that have already been implicated in the disease process. The potential remains high, particularly when combined with proteomic approaches. In addition, the utilization of transgenic mouse models will no doubt also be of tremendous value for gene expression studies as they permit investigations at well-defined stages of pathology and cognitive function.
LaFerla
Frank M
FM
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697-4545, USA. laferla@uci.edu
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D020869:Gene Expression Profiling / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D014018:Tissue Distribution
D015415:Biomarkers; D009419:Nerve Tissue Proteins