title: 2005 immunosuppressive strategies in kidney transplantation: which role for the calcineurin inhibitors?
abstract: The calcineurin inhibitors (CNIs) cyclosporine and tacrolimus have been the cornerstones of immunosuppressive strategies in clinical transplantation. Currently, regimens that are most widely used for induction and maintenance therapy include CNIs. However, many clinical trials aiming at reducing or eliminating CNIs have been performed in recent years. Here, we review and discuss current and future immunosuppressive strategies with a special emphasis on the role of CNIs, in the light of recent studies in the field of kidney transplantation. In the current era, CNIs still play an important role.
authors.affiliation: Renal and Transplantation Units, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Waichi
authors.initials: W
authors.lastname: Wong
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Venetz
authors.forename: Nina
authors.initials: N
authors.lastname: Tolkoff-Rubin
authors.forename: Manuel
authors.initials: M
authors.lastname: Pascual
mesh_terms: D065095:Calcineurin Inhibitors; D002986:Clinical Trials as Topic; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D016559:Tacrolimus / Q000494:pharmacology
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents; D016559:Tacrolimus