title: [Effects of low molecular weight heparin on vascular endothelial growth factor expression of early diabetic nephropathy].
abstract: OBJECTIVE
  To investigate the effects of low molecular weight heparin (LMWH) on vascular endothelial growth factor (VEGF) expression of early diabetic nephropathy.
  
  
  METHODS
  Ninety-five male SD rats were randomly divided into three groups: normal control rats, STZ-induced diabetic rats and diabetic rats treated with LMWH. The renal tissues were subjected to immunohistochemical staining after 1, 2, 4, 6, and 8 weeks' treatment respectively to quantify the VEGF expression.
  
  
  RESULTS
  Immunohistochemical staining demonstrated an increasing in VEGF positive cells in diabetic rats. It was found that there were significant differences in VEGF staining intensity between diabetic rats and normal control rats and between LMWH treated rats and untreated diabetic rats after two weeks treatment.
  
  
  CONCLUSIONS
  The inhibition of VEGF expression may be one of the mechanisms of LMWH's renal protective effects on early diabetic nephropathy.
authors.affiliation: Department of Nephrology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Liang-ying
authors.initials: LY
authors.lastname: Gan
authors.forename: Zhong-yuan
authors.initials: ZY
authors.lastname: Yu
authors.forename: Mei-shun
authors.initials: MS
authors.lastname: Cai
authors.forename: Hui-ping
authors.initials: HP
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D006495:Heparin, Low-Molecular-Weight; D042461:Vascular Endothelial Growth Factor A