Heteroaromatic side-chain analogs of pregabalin.
A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
Schelkun
Robert M
RM
PGRD Michigan Laboratories, Ann Arbor, MI 48105, USA.
Yuen
Po-wai
PW
Wustrow
David J
DJ
Kinsora
Jack
J
Su
Ti-Zhi
TZ
Vartanian
Mark G
MG
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004195:Disease Models, Animal; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D051379:Mice; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D000069583:Pregabalin; D012640:Seizures / Q000517:prevention & control*; D013237:Stereoisomerism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid