title: [Maternal diabetes and congenital malformations].
abstract: Maternal diabetes is a known risk factor for congenital malformations. Maternal hyperglycemia is a non-specific teratogen. The risk of congenital malformations, even with optimal metabolic control, is considerably elevated compared with non-diabetic pregnancies. The relationship between maternal hyperglycemia in early pregnancy and the risk of congenital malformations seems to be linear without any threshold level. To diminish the risk of congenital malformations, close preconceptional and first-trimester diabetic control and folic acid supplementation of 5 mg/day are recommended.
authors.affiliation: Syddansk Universitet, Epidemiologi, og Kolding Sygehus, Børneafdelingen. malene.johansen@get2net.dk
authors.forename: Malene Nygaard
authors.initials: MN
authors.lastname: Johansen
authors.forename: Ester
authors.initials: E
authors.lastname: Garne
mesh_terms: D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D012307:Risk Factors
chemical_list: D005492:Folic Acid