title: Long-term visual prognosis of infantile-onset high myopia.
abstract: OBJECTIVE
  To investigate the clinical course and changes of refractive status in infantile-onset myopic children who received fully corrected glasses and to determine their visual prognosis.
  
  
  METHODS
  In all, 57 children with infantile-onset high myopia (spherical equivalent over -5.0 D prior to the age of 5 years) were included in this study. All children received initial full-correction glasses at the mean age of 3.52 years. The cycloplegic refraction, axial length, and the best-corrected visual acuity were collected every 6 months. The mean follow-up time was 9.36 years.
  
  
  RESULTS
  We noted that the tendency toward progression or regression of myopia appeared to be related to the degree of refractive error. Lower grades of high myopia (-5.0 to -7.75 D) showed a greater tendency to progress than those of the highest initial myopic refraction level (< or = -11.0 D). While the latter group exhibited a more-substantial regression rate than those cases of the lower initial refraction level. About 80% of infantile-onset high myopes demonstrated a final best-corrected vision of greater than 20/40, with 37% of children revealing a best-corrected vision level even better than 20/25.
  
  
  CONCLUSIONS
  Clinical course of infantile high myopia is different to school myopia. Usually, higher degree of high myopia showed a stable state of myopia, or even possible regression, whereas the lower grades of high myopia revealed a strong tendency to progress.
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. yfshih@ha.mc.ntu.edu.tw
authors.forename: Y-F
authors.initials: YF
authors.lastname: Shih
authors.forename: T-C
authors.initials: TC
authors.lastname: Ho
authors.forename: C K
authors.initials: CK
authors.lastname: Hsiao
authors.forename: L L-K
authors.initials: LL
authors.lastname: Lin
mesh_terms: D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005139:Eyeglasses; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology