A novel HLA allele, DRB1*1609, identified in the Chinese Han population*.
A novel human leucocyte antigen-DRB1*16 (HLA-DRB1*16) allele (DRB1*1609) has been identified by sequencing-based typing (SBT) in Chinese Han population. This new allele has identical nucleotide sequence to DRB1*160101 in exon 2, except for a single-nucleotide substitution from A to T at position 127. This change leads to an amino acid change from tyrosine to phenylalanin at residue 47 (Y47F). SBT was performed for cloned DRB1*16-specific polymerase chain reaction fragment. The serological phenotype of DRB1*1609 is equivalent to DR16 antigen.
Miao
K R
KR
The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiang Su Province, P.R. China.
Pan
Q Q
QQ
Xue
M
M
Zhou
X Y
XY
Fei
X M
XM
Tang
Y H
YH
Xu
R
R
Zhang
J W
JW
Zhao
X
X
Osowski
L
L
Shi
W X
WX
Xu
A L
AL
Wang
C Y
CY
KuKuruga
D
D
D000483:Alleles; D001483:Base Sequence; D002681:China; D005091:Exons; D005192:Family Health; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010641:Phenotype; D010649:Phenylalanine / Q000737:chemistry; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014443:Tyrosine / Q000737:chemistry
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C506474:HLA-DRB1*16:09 antigen; D014443:Tyrosine; D010649:Phenylalanine