Inflammatory response on the pancreatic acinar cell injury.
Acute pancreatitis is an inflammatory disorder, and inflammation not only affects the pathogenesis but also the course of the disease. Acinar cell injury early in acute pancreatitis leads to a local inflammatory reaction; if marked this leads to a systemic inflammatory response syndrome (SIRS). An excessive SIRS leads to distant organ damage and multiple organ dysfunction syndrome (MODS). MODS associated with acute pancreatitis is the primary cause of morbidity and mortality in this condition. Recent studies by us and other investigators have established the critical role played by inflammatory mediators such as TNF-alpha, IL-1beta, IL-6, IL-8, CINC/GRO-alpha, MCP-1, PAF, IL-10, CD40L, C5a, ICAM-1, MIP1-alpha, RANTES, substance P, and hydrogen sulfide in acute pancreatitis and the resultant MODS. This review intends to present an overview of the inflammatory response that takes place following pancreatic acinar cell injury.
Bhatia
M
M
Department of Pharmacology, National University of Singapore, Faculty of Medicine, Singapore. mbhatia@nus.edu.sg
D000208:Acute Disease; D019013:CD40 Antigens / Q000032:analysis; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D007375:Interleukin-1 / Q000032:analysis; D016753:Interleukin-10 / Q000032:analysis; D009102:Multiple Organ Failure / Q000503:physiopathology*; D015260:Neprilysin / Q000502:physiology; D010179:Pancreas / Q000166:cytology*; D010195:Pancreatitis / Q000473:pathology*; D045169:Severe Acute Respiratory Syndrome / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D019013:CD40 Antigens; D018836:Inflammation Mediators; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10; D013373:Substance P; D015260:Neprilysin