A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients.
BACKGROUND
Several groups have shown the involvement of oxidative stress in the pathophysiology of vitiligo.


METHODS
In this study, we examined the erythrocyte and plasma activities of glutathione peroxidase and Cu/Zn superoxide dismutase, plasma nitrite/nitrate levels, and erythrocyte catalase activity in 23 vitiligo patients and 25 controls.


RESULTS
The results show that erythrocyte superoxide dismutase activity and plasma nitrite/nitrate levels are high in vitiligo patients.


CONCLUSIONS
Our study confirms that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of erythrocyte superoxide dismutase activity and plasma nitrite/nitrate.
Hazneci
Ersoy
E
Department of Dermatology, University of Inonu, Malatya, Turkey. hazneci@hotmail.com
Karabulut
Aysun Bay
AB
Oztürk
Cetin
C
Batçioğlu
Kadir
K
Doğan
Gürsoy
G
Karaca
Semsettin
S
Eşrefoğlu
Muammer
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002374:Catalase / Q000097:blood; D004798:Enzymes / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood; D009573:Nitrites / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D014820:Vitiligo / Q000097:blood* / Q000201:enzymology
D004798:Enzymes; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase