[Clinical consequences of dioxins exposure during tooth development].
Commonly designed by the term "dioxins", polychlorinated aromatic hydrocarbons are environmental pollutants leading to several toxic effects during development and growth in embryo and child. The general consequences of dioxin exposure are particularly well-documented whereas only few data are mentioned by the experts concerning tooth development. However, studies performed in rodents have shown many disruptions during odontogenesis and enamel mineralisation. Moreover, recent epidemiological studies have demonstrated in human the incidence of dioxin exposure on enamel hypomineralisation and hypodontia. The aim of this review is to report recent data about consequences of dioxin exposure on tooth development, tooth being considered as a biological marker of potential dioxin poisoning.
Maurin
J C
JC
Laboratoire Développement et régénération des tissus dentaires Inserm, ESPRI, EA 1892, IFR 62, faculté d'odontologie, université Lyon-I, rue Guillaume-Paradin, 69372 Lyon cedex 08, France.
Bleicher
F
F
Magloire
H
H
D000848:Anodontia / Q000139:chemically induced*; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004147:Dioxins / Q000506:poisoning*; D004785:Environmental Pollutants / Q000506:poisoning*; D016021:Epidemiologic Studies; D006801:Humans; D007223:Infant; D014070:Tooth / Q000187:drug effects / Q000254:growth & development; D017001:Tooth Demineralization / Q000139:chemically induced*
D015415:Biomarkers; D004147:Dioxins; D004785:Environmental Pollutants