title: The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst.
abstract: The development of an NHC-based system capable of cross-coupling sp(3)-sp(3) centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. [reaction: see text]
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada.
authors.forename: Niloufar
authors.initials: N
authors.lastname: Hadei
authors.forename: Eric Assen B
authors.initials: EA
authors.lastname: Kantchev
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Brien
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ