[The hypoglycemic effects of crude polysaccharides extract from Momordica charantia in mice].
OBJECTIVE
In order to study the hypoglycemic effects of crude polysaccharides extract from Momordica charantia in normal and diabetic mice.


METHODS
Oral glucose tolerance test was carried out in 24 normal mice, CPS was orally administered in experiment group at 1 g/kg BW. 80 diabetic mice (type 1 and type 2 diabetic model) were divided into two groups randomly, CPS was administered at ad lib and fasted condition in experiment group at 1 g/kg BW, blood glucose was measured at different time.


RESULTS
In normal mice, after administered glucose (3g/kgBW) the blood glucose level of experiment group at 0.5, 1 h was significantly lower than that of control group (16.4% and 16.5% lower than control group respectively, P < 0.05 and P < 0.01). In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h, 4h were lower than that of control group (P < 0.05 and P < 0.01 respectively).


CONCLUSIONS
CPS can improve OGTT in normal mice, and has significant hypoglycemic effect in two types diabetic mice.
Zheng
Zi-Xin
ZX
Department of Nutrition, General Hospital of Chinese PLA, Beijing 100853, China.
Teng
Jun-Ying
JY
Liu
Jian-Ying
JY
Qiu
Ji-Hong
JH
Ouyang
Hong
H
Xue
Changyong
C
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides