title: Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study.
abstract: Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological and immunohistochemical variations. At a meeting of international experts on pancreatic precursor lesions held in 2003, it was agreed that a consensus classification of IPMN subtypes should be established to enable a more detailed analysis of the clinicopathological significance of the variations. Based on our experience and on information from the literature, we selected representative histological examples of IPMNs and defined a consensus nomenclature and criteria for classifying variants as distinctive IPMN subtypes including gastric type, intestinal type, pancreatobiliary type, and oncocytic type. These definitions can be used for further analyses of the clinicopathological significance of the variations of IPMN.
authors.affiliation: Department of Molecular Pathology, Tohoku University School of Medicine, 2-1 Seiryomachi, Sendai, 980-8575, Japan. furukawa@mail.tains.tohoku.ac.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Furukawa
authors.forename: Günter
authors.initials: G
authors.lastname: Klöppel
authors.forename: N
authors.initials: N
authors.lastname: Volkan Adsay
authors.forename: Jorge
authors.initials: J
authors.lastname: Albores-Saavedra
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Fukushima
authors.forename: Akira
authors.initials: A
authors.lastname: Horii
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: Yo
authors.initials: Y
authors.lastname: Kato
authors.forename: David S
authors.initials: DS
authors.lastname: Klimstra
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Longnecker
authors.forename: Jutta
authors.initials: J
authors.lastname: Lüttges
authors.forename: G Johan A
authors.initials: GJ
authors.lastname: Offerhaus
authors.forename: Michio
authors.initials: M
authors.lastname: Shimizu
authors.forename: Makoto
authors.initials: M
authors.lastname: Sunamura
authors.forename: Arief
authors.initials: A
authors.lastname: Suriawinata
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Takaori
authors.forename: Suguru
authors.initials: S
authors.lastname: Yonezawa
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D018282:Cystadenocarcinoma, Mucinous / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D018283:Cystadenocarcinoma, Papillary / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007124:Immunoenzyme Techniques; D009077:Mucins / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000145:classification* / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins