Histopathological studies of aortic dissection in streptozotocin-induced diabetic APA hamsters.
Syrian hamsters of the APA strain (APA hamsters) are known to show continuous diabetes accompanied by its complications, such as glomerulosclerosis and atherosclerosis, following a single injection of streptozotocin (SZ). Recently, we observed Stanford type B aortic dissection in three diabetic APA hamsters and histopathological analysis was performed. The histopathologic observations in the false lumen, such as proliferation of granulation tissues, neointima and pseudoneointima, corresponded to the non-thrombosed type of human aortic dissection, and blood clots of the thrombosed type were similar to the remodeling structures of aortic dissection found in human cases. Thus, this model may be useful for investigating the etiology and pathogenesis of aortic dissection accompanying diabetes mellitus in humans.
Horiuchi
Keiko
K
Department of Biomedical Science, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, Japan.
Takatori
Atsushi
A
Inenaga
Toshiaki
T
Ohta
Etsuko
E
Ishii
Yoshiyuki
Y
Kyuwa
Shigeru
S
Yoshikawa
Yasuhiro
Y
D000784:Aortic Dissection / Q000209:etiology / Q000473:pathology*; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism / Q000473:pathology; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology*; D019084:Fluorescent Antibody Technique, Indirect; D007124:Immunoenzyme Techniques; D008297:Male; D008647:Mesocricetus; D013311:Streptozocin; D013927:Thrombosis / Q000150:complications / Q000473:pathology; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides; D013311:Streptozocin; D002784:Cholesterol