title: Acanthosis nigricans as an adverse effect of highly active antiretroviral therapy in an adolescent girl with human immunodeficiency virus infection.
abstract: We report an 11-year-old girl with acanthosis nigricans that appeared after 4 years of treatment with didanosine, stavudine and amprenavir. Laboratory studies showed hyperglycemia, hyperinsulinemia and hypertriglyceridemia. Withdrawal of amprenavir resulted in disappearance of acanthosis nigricans and improvement of metabolic abnormalities.
authors.affiliation: Service of Pediatrics, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mur
authors.forename: Veronica
authors.initials: V
authors.lastname: Seidel
authors.forename: María Angeles
authors.initials: MA
authors.lastname: López-Vílchez
authors.forename: Mariona
authors.initials: M
authors.lastname: Bonet
authors.forename: Montserrat
authors.initials: M
authors.lastname: Gilaberte
mesh_terms: D000052:Acanthosis Nigricans / Q000139:chemically induced*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans