Nek2 kinase in chromosome instability and cancer.
Aneuploidy and chromosome instability are two of the most common abnormalities in cancer cells. They arise through defects in cell division and, specifically, in the unequal segregation of chromosomes between daughter cells during mitosis. A number of cell cycle dependent protein kinases have been identified that control mitotic progression and chromosome segregation. Some of these localize to the centrosome and regulate mitotic spindle formation. One such protein is Nek2, a member of the NIMA-related serine/threonine kinase family. Data are emerging that Nek2 is abnormally expressed in a wide variety of human cancers. In this review, we summarize current knowledge on the expression, regulation and function of Nek2, consider how Nek2 may contribute to chromosome instability, and ask whether it might make an attractive target for chemotherapeutic intervention in human cancer.
Hayward
Daniel G
DG
Department of Biochemistry, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.
Fry
Andrew M
AM
D000782:Aneuploidy; D000818:Animals; D002455:Cell Division; D018385:Centrosome / Q000378:metabolism; D043171:Chromosomal Instability; D018450:Disease Progression; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D000072379:NIMA-Related Kinases; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D017434:Protein Structure, Tertiary
C089441:NEK2 protein, human; D000072379:NIMA-Related Kinases; D017346:Protein Serine-Threonine Kinases