[Oxidative and free-radical processes in the mechanism of toxic effect of anti-diabetic drugs dicarboxylic acids derivatives].
Dynamics of changes in the processes of the lipids free-radical peroxide oxidation (LPO), state of the monooxygenase system (MOS) and system of anti-oxidant protection (SAOP) in the liver and blood of rats under multiple peroral and inhalatory expositions of anti-diabetic drugs--dicarboxylic acids derivatives: phensuccinalum (PhS) and diacamph (Dc) in toxic and sub-toxic doses is studied. It has been found that one of the key biochemical mechanisms which determines the early signs of the toxic damage in the cells and organism under the effect of certain doses/concentrations of PhS (500 and 100 mg/kg, 20.2 mg/m3) and Dc (1000 mg/kg) consists in intensification of the free-radical processes, including, in particular, LPO combined with activation of MOGS and inhibition of SAOP in microsomal fraction of the liver. The high significance of changes of researched parameters for an assessment or forecasting of toxicity of dicarboxylic acids derivates is shown. Unlike the liver, the PhS and Dc impact on the blood caused changes of compensatory-adaptive nature in the LPO and SAOP systems.
Palahina
I A
IA
Kolodub
F A
FA
Kudria
M Ia
MIa
Ustenko
N V
NV
Ivanov
S V
SV
Mel'nykivs'ka
N V
NV
Mohylat
L V
LV
Lotskina
V B
VB
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003998:Dicarboxylic Acids / Q000633:toxicity*; D005260:Female; D005609:Free Radicals / Q000097:blood / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D003998:Dicarboxylic Acids; D005609:Free Radicals; D007004:Hypoglycemic Agents; D008054:Lipid Peroxides; D006899:Mixed Function Oxygenases