Coexistent sarcoidosis and HIV infection: an immunological paradox?
The CD4 lymphocyte plays a pivotal role in both sarcoidosis and HIV infection. Caring for a patient with both conditions represents a diagnostic and therapeutic challenge. We describe a patient, previously diagnosed with sarcoidosis, who subsequently contracted HIV infection. Manifestations of sarcoidosis were clinically silent until highly active anti-retroviral therapy was instituted. Her condition improved with the institution of corticosteroids. The diagnostic and therapeutic dilemmas encountered in patients with both conditions will be discussed including a complete review of the literature.
Almeida
Francisco Aécio
FA
Division of Critical Care, Pulmonary, Allergic, and Immunologic Diseases, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. francisco.almeida@jefferson.edu
Sager
Jeffrey S
JS
Eiger
Glenn
G
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D011241:Prednisone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy / Q000276:immunology*
D019380:Anti-HIV Agents; D011241:Prednisone