title: Biotransformation of alpha-santonin by cell suspension cultures of five plants.
abstract: Cell suspension cultures of five plants (Catharanthus roseus, Ginkgo biloba, Platycodon grandiflorum, Taxus cuspidata, Phytolacca asinosa) were employed to bioconvert the eudesmanolide compound, alpha-santonin. Reactions occurring were hydroxylation (C-1, C-11 and C-15), reduction of the double bond [1(2) or 3(4)], rearrangment of the eudesmanolide skeleton to a guaianolide skeleton and lactone-ring hydrolysis. Four new compounds were identified.
authors.affiliation: College of Life and Environmental Sciences, The Central University for Nationalities, 100081, Beijing, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Jungui
authors.initials: J
authors.lastname: Dai
authors.forename: Junichi
authors.initials: J
authors.lastname: Sakai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ando
mesh_terms: D001711:Biotransformation; D030008:Catharanthus / Q000166:cytology / Q000378:metabolism; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D020441:Ginkgo biloba / Q000166:cytology / Q000378:metabolism; D015394:Molecular Structure; D029603:Phytolacca / Q000166:cytology / Q000378:metabolism; D059828:Plant Cells; D010944:Plants / Q000378:metabolism*; D031238:Platycodon / Q000166:cytology / Q000378:metabolism; D012500:Santonin / Q000737:chemistry / Q000378:metabolism*; D013045:Species Specificity; D020946:Taxus / Q000166:cytology / Q000378:metabolism
chemical_list: D012500:Santonin