title: Coordination of DNA replication and cell division in cyanobacteria Microcystis aeruginosa.
abstract: Little is known about the cyanobacterial cell cycle. When either nalidixic acid or hydroxyurea was added to a synchronized culture of Microcystis aeruginosa to block DNA replication, cell division did not occur. Furthermore, transcription of the essential cell division gene, ftsZ was repressed. After DNA replication, ftsZ transcription, as well as cell division, was not affected by hydroxyl urea, suggesting that the DNA replication and cell division of M. aeruginosa are coordinated and that this coordination is partly controlled by ftsZ transcription depending on DNA replication.
authors.affiliation: Department of Marine Bioscience, Fukui Prefectural University, Obama, Fukui 917-0003, Japan. yoshiten@fpu.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Misae
authors.initials: M
authors.lastname: Maki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Okamoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Hiroishi
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D002876:Chromosomes, Bacterial / Q000378:metabolism; D015169:Colony Count, Microbial; D003598:Cytoskeletal Proteins / Q000502:physiology; D004261:DNA Replication / Q000187:drug effects; D006918:Hydroxyurea / Q000494:pharmacology; D046931:Microcystis / Q000166:cytology / Q000502:physiology*; D009268:Nalidixic Acid / Q000494:pharmacology; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; D019384:Nucleic Acid Synthesis Inhibitors; D009268:Nalidixic Acid; D006918:Hydroxyurea