title: Upper vaginectomy for the treatment of vaginal intraepithelial neoplasia.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the use of upper vaginectomy for the treatment of vaginal intraepithelial neoplasia (VAIN).
  
  
  METHODS
  We conducted a retrospective review. Between August 1, 1985 and April 30, 2004, 105 patients were identified who had undergone upper vaginectomy for VAIN.
  
  
  RESULTS
  Thirty-six patients had previously been treated for VAIN. Mean operative time and estimated blood loss were 55 minutes and 113 mL, respectively. Ten percent had intraoperative complications. Twenty-three (22%) patients had negative findings on final pathologic examination, and invasive cancer was found in 13 (12%) patients. Four patients had postoperative complications. Follow-up was available in 52 patients; 46 (88%) remain without recurrence at a mean follow-up of 25 months.
  
  
  CONCLUSIONS
  In our patients, upper vaginectomy was efficacious for the treatment of VAIN. The procedure led to the diagnosis of occult invasive cancer in 12% of these women.
authors.affiliation: Department of Gynecology Onclogy, University of South Florida, Tampa, FL, USA.
authors.forename: Megan D
authors.initials: MD
authors.lastname: Indermaur
authors.forename: Martin A
authors.initials: MA
authors.lastname: Martino
authors.forename: James V
authors.initials: JV
authors.lastname: Fiorica
authors.forename: William S
authors.initials: WS
authors.lastname: Roberts
authors.forename: Mitchel S
authors.initials: MS
authors.lastname: Hoffman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D003127:Colposcopy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D014621:Vagina / Q000601:surgery*; D014625:Vaginal Neoplasms / Q000601:surgery*