title: Focal lung uptake of 18F-fluorodeoxyglucose (18F-FDG) without computed tomography findings.
abstract: BACKGROUND
  Integrated positron emission tomography/computed tomography (PET/CT) systems represent a major development allowing functional and anatomical information to be acquired in a single examination session and therefore providing a more accurate definition of suspected lesion characteristics. Together with the increasing number of clinical settings in which PET/CT scans have been advocated, however, pitfalls in image interpretation have been reported.
  
  
  METHODS
  Four female subjects presenting a focal area of increased F-fluorodeoxyglucose (F-FDG) uptake with no evidence of a corresponding CT abnormality were included in the study. PET/CT scans were performed in all cases after the administration of 5.3 MBq . kg of F-FDG through a venous cannula.
  
  
  RESULTS
  Focal high uptake of F-FDG was observed in lung lesions without anatomical counterparts on CT in four female cases. The only common feature to all was the paravenous injection of the radiotracer.
  
  
  CONCLUSIONS
  The lesions detected by PET may be related to distal lung microembolism originating from the site of paravenous injection.
authors.affiliation: UO Medicina Nucleare, Università di Bologna, Policlinico S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Farsad
authors.forename: Valentina
authors.initials: V
authors.lastname: Ambrosini
authors.forename: Cristina
authors.initials: C
authors.lastname: Nanni
authors.forename: Paolo
authors.initials: P
authors.lastname: Castellucci
authors.forename: Stefano
authors.initials: S
authors.lastname: Boschi
authors.forename: Domenico
authors.initials: D
authors.lastname: Rubello
authors.forename: Mario
authors.initials: M
authors.lastname: Fabbri
authors.forename: Roberto
authors.initials: R
authors.lastname: Franchi
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18