title: Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study.
abstract: Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer.
authors.affiliation: Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, Aichi 466-8550, Japan. h828@med.nagoya-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuya
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Hoshiyama
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Fujino
authors.forename: Noritaka
authors.initials: N
authors.lastname: Tokui
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizoue
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Sakata
authors.forename: Norihiko
authors.initials: N
authors.lastname: Hayakawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kondo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Takesumi
authors.initials: T
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000097:blood* / Q000453:epidemiology; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1