Apo E genotype not associated with intravascular coagulation in traumatic brain injury.
There is considerable evidence linking both genotype and coagulopathy to vascular complications of traumatic brain injury (TBI) and other cerebral insults. The authors explored a possible connection between the apolipoprotein E (Apo E) genotype, coagulopathy and intravascular microthombosis (IMT) in TBI. The predicted association was not confirmed.
Stein
Sherman C
SC
Department of Neurosurgery, University of Pennsylvania, 105B Hayden Hall/3320 Smith Walk, Philadelphia, PA 19104-6316, USA.
Graham
David I
DI
Chen
Xiao-Han
XH
Dunn
Laurence
L
Smith
Douglas H
DH
D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications*; D002545:Brain Ischemia / Q000235:genetics* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000503:physiopathology*; D004252:DNA Mutational Analysis; D004211:Disseminated Intravascular Coagulation / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D020767:Intracranial Thrombosis / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics; D011517:Prothrombin Time
D001057:Apolipoproteins E; D020033:Protein Isoforms