A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis.
In this paper we wish to report on a variety of expedient chemical transformations and purifications achieved via a generic "catch and release" methodology, based on a synthetically inert bipyridyl chelating tag that can be selectively captured with a resin-bound copper(II) species. Utilising this approach we are able to derive many of the same benefits associated with both solid phase synthesis and supported reagent methods.
Siu
Jason
J
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Baxendale
Ian R
IR
Lewthwaite
Russell A
RA
Ley
Steven V
SV
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000302:isolation & purification*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
D008024:Ligands; D009942:Organometallic Compounds; D015082:2,2'-Dipyridyl; D003300:Copper