[Experimental studies of anti-proliferative effects of marinesponge extracts S1 - S3 on human lung adenocarcinoma and hepatocarcinoma cells].
OBJECTIVE
To study the anti-proliferative effects of marinesponge extract-S1 - S3 on human lung adenocarcinoma GLC-82, hepatocarcinoma 7402 and gastric carcinoma MCG-803 cells in vitro.


METHODS
The parameters were got by MTT assay.


RESULTS
After human lung adenocarcinoma GLC-82, hepatocarcinoma 7402 and gastric carcinoma MCG-803 cells were treated by marinesponge extract-S1 - S3 for 48h, the growth of lung adenocarcinoma GLC-82 and hepatocarcinoma 7402 cells were inhibited significantly by the S3 and the IC50 were 2. 714 microg/ml and 2. 598 microg/ml respectively; but no significant effect on the gastric carcinoma MCG-803 cells. The marinesponge extracts S1 and S2 don't show inhibitive effect on the proliferation of those three tumor cells.


CONCLUSIONS
Marine-sponge extract S3 can inhibit the proliferation of lung adenocarcinoma GLC-82 and hepatocarcinoma 7402 cells significantly.
Yang
Wenhao
W
Pharmacy College of Jinan University, Guangzhou.
Lui
Junhua
J
Xu
Shihai
S
D000230:Adenocarcinoma / Q000473:pathology*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D015251:Epirubicin / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology; D008419:Materia Medica / Q000494:pharmacology*; D011161:Porifera; D013274:Stomach Neoplasms / Q000473:pathology
D000470:Alkaloids; D000970:Antineoplastic Agents; D008419:Materia Medica; D015251:Epirubicin