Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy.
Phylogenetic analysis has led to the classification of hepatitis B virus into eight genotypes, designated A to H. The genotypes have differences in biological properties and show heterogeneity in their global distribution. These attributes of the genotypes may account not only for differences in the prevalence of hepatitis B virus mutants in various geographic regions, but also be responsible for differences in the clinical outcome and response to antiviral treatment in different population groups.
Kramvis
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A
MRC/University Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa. kramvisa@medicine.wits.ac.za
Kew
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MC
D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000821:virology; D004279:DNA, Viral / Q000235:genetics*; D018450:Disease Progression; D018740:Genetic Heterogeneity; D005838:Genotype; D006509:Hepatitis B / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D009154:Mutation; D015995:Prevalence; D011379:Prognosis
D000998:Antiviral Agents; D004279:DNA, Viral