Characterisation and biodistribution of two neutral 99mTc(CO)3 complexes with a tridentate ligand.
N-(2-Mercapto-propyl)-1,2-phenylenediamine (MPPDA) and N-beta-aminoethylglycine (AEG) were labelled with 99mTc(CO)3(+) to form the neutral complexes [99mTc(CO)3(MPPDA)] and [99mTc(CO)3(AEG)]. Both complexes were formed in excellent yields and their identity was confirmed by LC-MS. In mice, none of the new tracer agents showed brain uptake. [(99m)Tc(CO)3(MPPDA)] was trapped mainly in the liver and excreted via the hepatobiliary system, whereas [99mTc(CO)3(AEG)] was excreted rapidly via the kidneys to the urine.
Rattat
Dirk
D
Laboratory for Radiopharmaceutical Chemistry and Nuclear Medicine, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium.
Cleynhens
Bernard
B
Bormans
Guy
G
Terwinghe
Christelle
C
Verbruggen
Alfons
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D008024:Ligands; D008099:Liver / Q000378:metabolism; D013058:Mass Spectrometry; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D008024:Ligands; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals