title: Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform.
abstract: A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been established. This method includes a stereoselective double Mizoroki-Heck-type arylation, a Liebeskind-Srogl-type cross-coupling reaction, and a Pd/C-catalyzed hydrogenation.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Muraoka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mineno
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Itami
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yoshida