title: Wang-aldehyde resin as a recyclable support for the synthesis of alpha,alpha-disubstituted amino acid derivatives.
abstract: Merrifield resin was functionalised with hydroxybenzaldehyde under microwave irradiation. The resultant resin was used as a means for immobilisation and activation of alpha-amino acid esters for alkylation reactions. Alpha,alpha-disubstituted and cyclic amino acid esters were prepared in good yields.
authors.affiliation: Department of Chemistry, King's College London, Strand, London WC2R 2LS, UK.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Guinó
authors.forename: King Kuok Mimi
authors.initials: KK
authors.lastname: Hii
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000528:radiation effects; D000596:Amino Acids / Q000138:chemical synthesis*; D004952:Esters / Q000138:chemical synthesis*; D008872:Microwaves; D015394:Molecular Structure; D012117:Resins, Synthetic / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D004952:Esters; D012117:Resins, Synthetic