Role of inflammation in pancreatic carcinogenesis and the implications for future therapy.
BACKGROUND
The link between inflammation and pancreatic cancer has been observed for a number of gastrointestinal neoplasms. This review examines the role of inflammation in pancreatic carcinogenesis and how it can be utilised to develop new therapies against pancreatic cancer.


METHODS
A literature review of Pubmed, Medline and Web of Science databases was undertaken using the key words, pancreatic cancer, inflammation, inducible nitric oxide, interleukins, pro-inflammatory cytokines, cyclooxygenase-2, NF-kappa B, reactive oxygen species, DNA adducts, lipoxygenases, chemoprevention.


RESULTS
Epidemiological evidence and molecular studies both in vitro and in vivo all support the hypothesis that inflammation plays an important in the initiation and progression of pancreatic tumours.


CONCLUSIONS
Sustained damage caused by chronic inflammation may precede the onset of frank malignancy by a significant interval. As such, suppression of inflammatory changes and oxidative damage, may help delay or even prevent the inception of pancreatic neoplasia.
Garcea
G
G
Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, The Leicester Royal Infirmary, UK. gg43@le.ac.uk
Dennison
A R
AR
Steward
W P
WP
Berry
D P
DP
D051546:Cyclooxygenase 2; D016207:Cytokines / Q000502:physiology; D004249:DNA Damage; D006801:Humans; D007378:Interleukins / Q000037:antagonists & inhibitors / Q000502:physiology; D008084:Lipoxygenase / Q000378:metabolism; D008565:Membrane Proteins; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000628:therapy*; D010195:Pancreatitis / Q000150:complications* / Q000503:physiopathology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012306:Risk
D016207:Cytokines; D007378:Interleukins; D008565:Membrane Proteins; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D008084:Lipoxygenase; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases