title: Nonspecific granulomatous prostatitis with calculous ductal ectasia and extensive Paneth cell-like epithelial metaplasia. Case report.
abstract: We present a case of nonspecific granulomatous prostatitis in combination with calculous ductal ectasia and extensive epithelial Paneth cell-like metaplasia in a TURP-specimen. Our report highlights the importance of calculous ductal obstruction and stasis of secretions in the etiopathogenesis of this type of prostatitis. The observed extensive Paneth cell-like metaplastic change in adjacent epithelial cells most likely represents a phenotypic adaptive mechanism directed against foreign antigens and nondegradable lipids in the stagnant intraluminal debris.
authors.affiliation: Service d'Anatomie Pathologique, Centre Hospitalier de Lagny-Marne-La-Vallée, Lagny-sur-Marne, France. ddikov@ch-lagny77.fr
authors.forename: Dorian
authors.initials: D
authors.lastname: Dikov
authors.forename: Ivan
authors.initials: I
authors.lastname: Vassilev
authors.forename: Jordan
authors.initials: J
authors.lastname: Dimitrakov
mesh_terms: D000368:Aged; D002137:Calculi / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008297:Male; D008679:Metaplasia; D019879:Paneth Cells / Q000473:pathology; D011472:Prostatitis / Q000473:pathology*