Non-steroidal progesterone receptor specific ligands.
The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, non-steroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
Allan
G F
GF
Reproductive Therapeutics, Johnson & Johnson Pharmaceutical Research and Development, 1000 US Route 202 South P.O. Box 300, Raritan, New Jersey 08869, USA. gallan@prdus.jnj.com
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D000818:Animals; D001667:Binding, Competitive; D003267:Contraception; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008024:Ligands; D011372:Progestins / Q000494:pharmacology*; D011980:Receptors, Progesterone / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000145:classification; D013329:Structure-Activity Relationship
D008024:Ligands; D011372:Progestins; D011980:Receptors, Progesterone