Potential therapeutic role of peroxisome proliferator activated receptor-gamma agonists in psoriasis.
Psoriasis is a chronic inflammatory condition affecting 1 - 3% of the world's population. Despite the availability of several agents, therapeutic options remain limited. With a better understanding of the pathophysiology of psoriasis, several potential therapeutic targets have been identified. Peroxisome proliferator activated receptors have been shown to play a role in cutaneous homeostasis. This review focuses on the potential therapeutic role of peroxisome proliferator activated receptor-gamma agonists in psoriasis and the possibility for the future prospects.
Malhotra
Samir
S
PGIMER, Department of Pharmacology, Chandigarh, 160012, India. samirmalhotra345@yahoo.com
Bansal
Dipika
D
Shafiq
Nusrat
N
Pandhi
Promila
P
Kumar
Bhushan
B
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006706:Homeostasis; D006801:Humans; D047495:PPAR gamma / Q000819:agonists* / Q000378:metabolism; D011565:Psoriasis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D047495:PPAR gamma; D045162:Thiazolidinediones