Monochorionic-diamniotic twins resulting from the transfer of a single embryo in a woman with decreased egg reserve: a case report.
OBJECTIVE
To report the first case of identical twins born to a woman with decreased oocyte reserve having a single embryo transfer (ET).


METHODS
Minimal stimulation with gonadotropins (no more than 75 IU/day of human menopausal gonadotropins) for a few days followed by oocyte retrieval.


RESULTS
The woman, aged 37, had seven in vitro fertilization (IVF) cycles with minimal or no gonadotropin stimulation. An embryo was formed in four of seven retrieval cycles (57.1%). She conceived on her seventh cycle and delivered monochorionic diamniotic twins. This pregnancy was achieved with the transfer of six embryos over eight cycles (counting a hyperstimulated cycle performed previously in another IVF center following traditional controlled ovarian hyperstimulation).


CONCLUSIONS
This case demonstrates that successful pregnancies are possible with single embryo transfers in women with decreased egg reserve including identical twins.
Katsoff
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, NJ, USA.
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D000328:Adult; D000650:Amnion; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D010062:Ovulation Induction / Q000379:methods; D010063:Ovum / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D014430:Twins, Monozygotic