A case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10).
We describe an unusual case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10). The eosinophilic proliferation was severe in peripheral blood and bone marrow, and they revealed marked dysplastic features. We performed fluorescence in situ hybridization (FISH) and immunohistochemistry to evaluate the clonality of eosinophils. The eosinophils were stained positively to platelet-derived growth factor receptor-beta. By FISH using chromosome 1 satellite probe and chromosome 1q telomere probe, the eosinophils were proved to belong to the malignant clone.
Kim
Myungshin
M
Department of Clinical Pathology, College of Medicine, Catholic University of Korea, Seoul, Korea.
Lim
Jihyang
J
Lee
Ahwon
A
Park
Gyeongsin
G
Kim
Yonggoo
Y
Han
Kyungja
K
Kang
Chang Suk
CS
Kim
Yoo-Jin
YJ
Song
Jeong-Sup
JS
D000293:Adolescent; D002675:Child, Preschool; D002877:Chromosomes, Human / Q000235:genetics*; D004802:Eosinophilia / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004804:Eosinophils / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000096:biosynthesis; D014178:Translocation, Genetic
D020797:Receptor, Platelet-Derived Growth Factor beta