Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells.
Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-alpha and interferon-gamma production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
Katsuno
Goutarou
G
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japn.
Takahashi
Hideo K
HK
Iwagaki
Hiromi
H
Mizuno
Kenji
K
Mori
Shuji
S
Yoshino
Tadashi
T
Nishibori
Masahiro
M
Tanaka
Noriaki
N
D001550:Benzamidines; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis*; D020382:Interleukin-18 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear
D001550:Benzamidines; D006146:Guanidines; D020382:Interleukin-18; D018664:Interleukin-12; C032855:nafamostat