[Neurological late sequelae in twins born after in vitro fertilisation--secondary publication. A national cohort study].
Currently 4% of the Danish national birth cohort is born after in vitro fertilisation techniques and almost 40% of these children are twins. In this register-based national cohort study, twins from assisted conception (n = 3393) had a similar risk of neurological sequelae and cerebral palsy as their naturally conceived peers (n = 10.239) and assisted conceived singletons (n = 5130). Further children born after intracytoplasmic sperm injection (ICSI) had the same risk of neurological sequelae as children born after conventional IVF.
Pinborg
Anja
A
H:S Rigshospitalet, Fertilitetsklinikken og Neonatalklinikken, Københavns Universitet, Institut for Folkesundhedsvidenskab, ogSundhedsstyrelsen, Afdeling for Sundhedsstatistik. apinborg@rh.hosp.dk
Loft
Anne
A
Schmidt
Lone
L
Greisen
Gorm
G
Rasmussen
Steen
S
Andersen
Anders Nyboe
AN
D000328:Adult; D002547:Cerebral Palsy / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D004200:Diseases in Twins / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008423:Maternal Age; D009422:Nervous System Diseases / Q000453:epidemiology / Q000209:etiology*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011596:Psychomotor Disorders / Q000453:epidemiology / Q000209:etiology; D012042:Registries; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects*; D014427:Twins