Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma.
OBJECTIVE
To report a case of the lacrimal gland tumor diagnosed as carcinosarcoma (true mixed tumor) arising from a pleomorphic adenoma.


METHODS
Interventional case report.


METHODS
An 80-year-old Japanese woman was referred with a well-circumscribed tumor in the lacrimal fossa.


RESULTS
The tumor was excised, but the deepest portion remained because of heavy bleeding. Histopathologically, the tumor consisted of osteosarcomatous cells. No epithelial or myoepithelial component was identified by immunohistochemistry. Two months later, the tumor progressed further and was excised completely with lateral orbitotomy. The tumor consisted primarily of osteosarcomatous component but also had epithelial components including carcinoma and pleomorphic adenoma. Examinations did not detect local recurrence and metastasis at 10 post-operative months.


CONCLUSIONS
The tumor was diagnosed as true carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. When lacrimal gland tumors containing sarcomatous components are encountered, carcinosarcoma should be included in the differential diagnosis.
Takahira
Masayuki
M
Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa, Japan. takahira@kenroku.kanazawa-u.ac.jp
Nakamura
Yasuhisa
Y
Shimizu
Shin-Ichi
S
Minato
Hiroshi
H
Katori
Nobutada
N
Kobayashi
Hiroshi
H
Nakatani
Yusuke
Y
Sugiyama
Kazuhisa
K
D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005134:Eye Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor