title: Marchiafava-Bignami disease: diffusion-weighted MRI in corpus callosum and cortical lesions.
abstract: The clinical diagnosis of Marchiafava-Bignami disease (MBD) can be difficult. Acute demyelination of the corpus callosum is characteristic of the disease. The authors report the use of MR diffusion-weighted imaging (DWI) in six cases of acute MBD. They show that apparent diffusion coefficient restriction of the corpus callosum and cortical lesions were associated with a higher mortality rate and more severe cognitive sequelae.
authors.affiliation: Service de Neuroradiologie, Hôpital Pellegrin, CHU Bordeaux, France. patrice.menegon@chu-bordeaux.fr
authors.forename: P
authors.initials: P
authors.lastname: Ménégon
authors.forename: I
authors.initials: I
authors.lastname: Sibon
authors.forename: C
authors.initials: C
authors.lastname: Pachai
authors.forename: J M
authors.initials: JM
authors.lastname: Orgogozo
authors.forename: V
authors.initials: V
authors.lastname: Dousset
mesh_terms: D000328:Adult; D020268:Alcohol-Induced Disorders, Nervous System / Q000150:complications / Q000401:mortality / Q000473:pathology*; D000437:Alcoholism / Q000150:complications; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000150:complications / Q000401:mortality / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D014855:Wallerian Degeneration / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology
chemical_list: D000431:Ethanol