title: Use of serum bicarbonate measurement in place of arterial base deficit in the surgical intensive care unit.
abstract: OBJECTIVE
  Serum bicarbonate (HCO(3)) measurement may accurately and reliably be substituted for the arterial base deficit (BD) assay in the surgical intensive care unit (ICU).
  
  
  METHODS
  Retrospective criterion standard analysis.
  
  
  METHODS
  Surgical ICU in a tertiary care facility.
  
  
  METHODS
  Consecutive sample of non-trauma-related surgical ICU admissions from January 1996 to January 2004 with simultaneously obtained serum HCO(3) and arterial BD levels.
  
  
  METHODS
  Correlation between HCO(3) and BD at admission and during the ICU stay; predictive value of serum HCO(3) for significant metabolic acidosis and ICU mortality.
  
  
  RESULTS
  The study included 2291 patients with 26 063 sets of paired laboratory data. The mean +/- SD age was 52 +/- 16 years and mean ICU stay was 5.8 +/- 9.8 days. There were 174 ICU deaths (8%). Serum HCO(3) levels showed significant correlation with arterial BD levels both at admission (r = 0.85, R(2) = 0.72, P<.001) and throughout the ICU stay (r = 0.88, R(2) = 0.77, P<.001). Serum HCO(3) reliably predicted the presence of significant metabolic acidosis (BD > 5) with an area under the receiver operating characteristic curve (AUC) of 0.93 at admission and 0.95 overall (both P<.001), outperforming pH (AUC, 0.80), anion gap (AUC, 0.70), and lactate (AUC, 0.70). The admission serum HCO(3) level predicted ICU mortality as accurately as the admission arterial BD (AUCs of 0.68 and 0.70, respectively) and more accurately than either admission pH or anion gap.
  
  
  CONCLUSIONS
  Serum HCO(3) provides equivalent information to the arterial BD and may be used as an alternative predictive marker or guide to resuscitation. Low HCO(3) levels should prompt immediate metabolic acidosis evaluation and management.
authors.affiliation: Division of Trauma and Surgical Critical Care, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. docmartin2@yahoo.com
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Martin
authors.forename: Elizabeth
authors.initials: E
authors.lastname: FitzSullivan
authors.forename: Ali
authors.initials: A
authors.lastname: Salim
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Berne
authors.forename: Shirin
authors.initials: S
authors.lastname: Towfigh
mesh_terms: D000138:Acidosis / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001784:Blood Gas Analysis; D015331:Cohort Studies; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D006403:Hematologic Tests; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011336:Probability; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D001639:Bicarbonates; D015415:Biomarkers