title: Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl)pyridinium.
abstract: A new AChE tracer N-[(11)C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl)pyridinium ([(11)C]MDDP, [(11)C]1) has been synthesized in 40-65% radiochemical yield. Initial PET dynamic studies of [(11)C]MDDP in rat heart showed rapid heart uptake and blood pool clearance to give high-quality heart images. Blocking studies of [(11)C]MDDP with pretreatment drug neostigmine in rats found only minor reductions in rat heart [(11)C]MDDP retention. The results suggest that [(11)C]MDDP delineates the heart very clearly, and the uptakes of [(11)C]MDDP in rat heart might be related to non-specific binding.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
authors.forename: Ji-Quan
authors.initials: JQ
authors.lastname: Wang
authors.forename: Michael A
authors.initials: MA
authors.lastname: Miller
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Mock
authors.forename: John C
authors.initials: JC
authors.lastname: Lopshire
authors.forename: William J
authors.initials: WJ
authors.lastname: Groh
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Zipes
authors.forename: Gary D
authors.initials: GD
authors.lastname: Hutchins
authors.forename: Qi-Huang
authors.initials: QH
authors.lastname: Zheng
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000097:blood / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D049268:Positron-Emission Tomography; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D051381:Rats
chemical_list: C505997:N-(11C)methyl-3-(((dimethylamino)carbonyl)oxy)-2-(2',2'-diphenylpropionoxymethyl)pyridinium; D011726:Pyridinium Compounds; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase