Retinoids as therapeutic agents: today and tomorrow.
Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.
Vivat-Hannah
Valerie
V
ALIX, Bio-Incubateur de l'ESBS, Boulevard Sebastien Brandt, 67400 Illkirch, France. vivat@alix-pharma.fr
Zusi
F Christopher
FC
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004304:Dosage Forms; D004347:Drug Interactions; D006801:Humans; D023421:Models, Animal; D009369:Neoplasms / Q000188:drug therapy*; D012176:Retinoids / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004304:Dosage Forms; D012176:Retinoids; D014157:Transcription Factors