Risk factors for mortality in children with candidemia.
We performed a retrospective cohort study of hospitalized children with positive blood cultures for Candida species. Independent risk factors for mortality by multivariable analysis were location in the pediatric intensive care unit at the time of infection (hazard ratio, 6.3; 95% confidence interval, 1.6-24.3) and the presence of an arterial catheter (hazard ratio, 2.4; 95% confidence interval, 1.1-5.8). Our findings help identify a group of pediatric patients that should be targeted for future interventions to prevent and treat candidemia.
Zaoutis
Theoklis E
TE
Division of Infectious Diseases, The Children's Hospital of Philadelphia, PA 19104, USA. zaoutis@email.chop.edu
Coffin
Susan E
SE
Chu
Jaclyn H
JH
Heydon
Kateri
K
Zhao
Huaqing
H
Greves
H Mollie
HM
Walsh
Thomas J
TJ
D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy / Q000401:mortality*; D002648:Child; D015331:Cohort Studies; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors
D000935:Antifungal Agents