title: Microangiopathic hemolytic anemia (MAHA) as paraneoplastic syndrome in metastasized signet ring cell carcinomas: case reports and review of the literature.
abstract: We report on two spontaneous cases of microangiopathic hemolytic anemia (MAHA) as first manifestation due to metastasized signet ring carcinoma, one of gastric and one of unknown origin. The patients presented with an acute onset of Coombs negative hemolytic anemia and fragmentocytes in the peripheral blood smear which are typical for MAHA. These case reports present MAHA as a rare paraneoplastic syndrome in patients with metastasized signet ring carcinoma. Parallel to symptomatic treatment we started chemotherapy treatment (ELF and PLF regimen, respectively). In both cases we were able to control the MAHA and cancer progression.
authors.affiliation: Klinik für Innere Medizin, Klinikum Bremen Ost, Bremen, Germany. htarkenau@aol.com
authors.forename: H-T
authors.initials: HT
authors.lastname: Arkenau
authors.forename: O
authors.initials: O
authors.lastname: Müssig
authors.forename: T
authors.initials: T
authors.lastname: Buhr
authors.forename: H H
authors.initials: HH
authors.lastname: Jend
authors.forename: R
authors.initials: R
authors.lastname: Porschen
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology* / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001803:Blood Transfusion; D019046:Bone Marrow Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D018279:Carcinoma, Signet Ring Cell / Q000150:complications / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary; D010257:Paraneoplastic Syndromes / Q000175:diagnosis; D013274:Stomach Neoplasms / Q000601:surgery; D013997:Time Factors