title: [Anti-ischemic efficacy of combination of trimetazidine with enalapril in patients with stable effort angina and metabolic syndrome].
abstract: Efficacy of combination of trimetazidine (60 mg/day) and enalapril in patients with stable effort angina and metabolic syndrome was assessed in a randomized placebo controlled study of 64 patients. Anti-ischemic activity of trimetazidine was found to be significant. It was most pronounced in patients with abnormal 24-hour blood pressure index, waist/hip circumference ratio >1.0 at the background of satisfactory clinical and laboratory compensation of type 2 diabetes.
authors.forename: T I
authors.initials: TI
authors.lastname: Petelina
authors.forename: L I
authors.initials: LI
authors.lastname: Gapon
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Bakhmatova
authors.forename: I A
authors.initials: IA
authors.lastname: Zhevagina
authors.forename: V A
authors.initials: VA
authors.lastname: Kalinina
authors.forename: V V
authors.initials: VV
authors.lastname: Todosiĭchuk
authors.forename: V A
authors.initials: VA
authors.lastname: Kuznetsov
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D004359:Drug Therapy, Combination; D015716:Electrocardiography, Ambulatory; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged; D016896:Treatment Outcome; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D014665:Vasodilator Agents; D004656:Enalapril; D014292:Trimetazidine