[Expression of transcription factor in Barrett's esophagus].
Barrett's esophagus is the result of chronic injury which is usually caused by gastroesophageal reflux. NF-kappaB is expressed in the reflux esophagitis. Specialized columnar epithelium (SCE) is characteristic of Barrett's esophagus and has a malignant predisposition. SCE expresses Cdx1 and Cdx2. Adenocarcinoma in Barrett's esophagus is believed to develop through the metaplasia-dysplasia-carcinoma sequence. P53, beta-catenin, PPARgamma, and estrogen receptor beta are closely related to the development of esophageal carcinogenesis.
Mutoh
Hiroyuki
H
Department of Gastroenterology, Jichi Medical School.
D000230:Adenocarcinoma / Q000235:genetics; D001471:Barrett Esophagus / Q000235:genetics*; D000071616:CDX2 Transcription Factor; D003598:Cytoskeletal Proteins; D004938:Esophageal Neoplasms / Q000235:genetics; D004947:Esophagus / Q000473:pathology; D047629:Estrogen Receptor beta; D005764:Gastroesophageal Reflux / Q000235:genetics; D016158:Genes, p53; D018398:Homeodomain Proteins; D006801:Humans; D008679:Metaplasia / Q000235:genetics; D016328:NF-kappa B; D047495:PPAR gamma; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin
C491273:CDX1 protein, human; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D047629:Estrogen Receptor beta; D018398:Homeodomain Proteins; D016328:NF-kappa B; D047495:PPAR gamma; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin