title: Bilateral primary orbital non-Hodgkin's lymphoma in a patient with scleroderma: a case report.
abstract: Orbital presentation of non-Hodgkin's Lymphoma (NHL) is uncommon but occurs both as the only site of disease and as a site of recurrence. Primary orbital NHLs are usually low-grade, and mostly extranodal marginal zone/mucosa associated lymphoid tissue B-cell neoplasms. They are commonly associated with chronic inflammatory conditions. The issue of bilaterality in orbital lymphoma is not very common. The onset of malignant lymphoproliferation may precede, follow, or exist simultaneously with scleroderma. Different treatment modalities were applied in orbital NHL such as surgery, radiation therapy, chemotherapy or both. We report a 57-year-old man with scleroderma presenting with eyelid hernias who had biopsy-proven marginal zone NHL, successfully treated with radiotherapy and combined chemotherapy, and also review the literature.
authors.affiliation: Division of Hematology, Dokuz Eylul University School of Medicine, Inciralti Izmir, Turkey.
authors.forename: Inci
authors.initials: I
authors.lastname: Alacacioglu
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Ozcan
authors.forename: Nilufer
authors.initials: N
authors.lastname: Kocak
authors.forename: Ayse
authors.initials: A
authors.lastname: Demiral
authors.forename: Ozden
authors.initials: O
authors.lastname: Piskin
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirkan
authors.forename: Guner Hayri
authors.initials: GH
authors.lastname: Ozsan
authors.forename: Ali Osman
authors.initials: AO
authors.lastname: Saatci
authors.forename: Bulent
authors.initials: B
authors.lastname: Undar
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002452:Cell Count; D005141:Eyelid Diseases / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D012074:Remission Induction; D045745:Scleroderma, Limited / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D016896:Treatment Outcome