[The spatial organization of DNA in the nucleus may determine positions of recombination hot-spots].
We suggest a hypothesis postulating that sites of DNA loop anchorage to the nuclear matrix harbor "hot spots" of illegitimate recombination which is mediated or triggered by topoisomerase II of the nuclear matrix. Recombination between DNA loop anchorage sites may result in deletion and/or repositioning of DNA loops and loop oligomers. This hypothesis is corroborated by our own results and published results of other research groups.
Razin
S V
SV
Iarovaia
O V
OV
D002467:Cell Nucleus / Q000235:genetics*; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D011995:Recombination, Genetic
D004247:DNA; D004250:DNA Topoisomerases, Type II