Transcriptional regulation at the chromatin level in the cardiovasculature through protein-protein interactions and chemical modifications.
Transcriptional regulation in eukaryotes requires an understanding of the regulation of the chromatin structure. Chromatin is the eukaryotic-specific packaging/compaction of DNA with nucleosomal histones. This present review discusses recent advancements made in the field of chromatin-associated transcriptional regulation and their implications to the cardiovasculature.
Suzuki
Toru
T
Department of Cardiovascular Medicine, Graduate School of medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. torusuzu-tky@umin.ac.jp
Matsumura
Takayoshi
T
Nagai
Ryozo
R
D002320:Cardiovascular Physiological Phenomena; D002843:Chromatin / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D011506:Proteins