Results of alcohol and albendazole injections in hepatic hydatidosis: experimental study.
BACKGROUND
Percutaneous drainage with alcohol injection for hydatid cysts has been commonly used in the last two decades. Albendazole is the drug of choice in the medical treatment of hydatidosis, and has also been used as an intraoperative scolicidal solution. The side-effects of its local application are not well known and have not been investigated. The purpose of the present study was to investigate the effects of the intracystic injections of alcohol and albendazole solutions on the hydatid cysts and hepatobiliary system of rabbits.


METHODS
There were three groups of eight rabbits: a control group, an alcohol group and an albendazole group. In all groups hepatic hydatidosis was obtained. The control group received no therapeutic procedure. Cyst liquid was aspirated, and alcohol or albendazole solutions were injected in the other two study groups. alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) levels, echinococcus indirect hemagglutination (IHA) tests, and the size and volume of the residual cysts were investigated. Liver was histopathologically evaluated.


RESULTS
The ALT, AST, GGT, and alkaline phosphatase (ALP) levels were significantly higher in the alcohol group, whereas echinococcus IHA level was highest in the control group than in the study groups. Albendazole had similar effects but of a lesser degree (P < 0.01). After therapy, the cyst volume was greater in the control than in the albendazole group (P < 0.01). In histopathological evaluation hepatocellular necrosis, portal inflammation and fibrosis were most severe in the alcohol group (P < 0.01).


CONCLUSIONS
Alcohol and albendazole solutions are effective as scolicidal solutions. Higher scolicidal effect and lesser side-effects on hepatobiliary system are the advantages of albendazole solution.
Yetim
Ibrahim
I
Department of General Surgery, Medical Faculty, Ondokuzmayis University, Samsun, Turkey.
Erzurumlu
Kenan
K
Hokelek
Murat
M
Baris
Sancar
S
Dervisoglu
Adem
A
Polat
Cafer
C
Belet
Umit
U
Buyukkarabacak
Yalçin
Y
Guvenli
Abdullah
A
D015766:Albendazole / Q000008:administration & dosage*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001659:Biliary Tract / Q000187:drug effects*; D004322:Drainage; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000601:surgery; D000431:Ethanol / Q000008:administration & dosage*; D015552:Injections, Intralesional; D011817:Rabbits; D012996:Solutions / Q000008:administration & dosage
D000891:Anti-Infective Agents, Local; D012996:Solutions; D000431:Ethanol; D015766:Albendazole