title: L-selectin: adhesion, signalling and its importance in pathologic posttraumatic endotoxemia and non-septic inflammation.
abstract: The leucocyte expressed surface-bound L-selectin belongs to the selectin family of adhesion molecules. It exhibits adhesive as well as signalling functions. Mainly, it is of importance in lymphocyte homing and in the extravasation of leucocytes into the surrounding tissue during inflammation. Acting in the initial step of the cell adhesion cascade, L-selectin is responsible for the rolling of leucocytes on endothelial layers. Therefore, L-selectin is thought to be an adequate target for pharmacological interventions. Beneath the discussion of the molecules' general features like molecule structure and its regulation, the review focuses firstly on L-selectin in the context of posttraumatic inflammatory disorders, and secondly on the importance of L-selectin specific signalling events.
authors.affiliation: Experimental Trauma Surgery, Department of Trauma Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, Germany. barkhausen.tanja@mh-hannover.de
authors.forename: Tanja
authors.initials: T
authors.lastname: Barkhausen
authors.forename: Christian
authors.initials: C
authors.lastname: Krettek
authors.forename: Martijn
authors.initials: M
authors.lastname: van Griensven
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D019446:Endotoxemia / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D019041:L-Selectin / Q000276:immunology / Q000378:metabolism*; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction; D014947:Wounds and Injuries / Q000150:complications* / Q000276:immunology / Q000378:metabolism
chemical_list: D019041:L-Selectin