title: The role of Abeta peptides in Alzheimer's disease.
abstract: The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Abeta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.
authors.affiliation: School of Chemistry, University of Melbourne, VIC 3010, Australia.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Tickler
authors.forename: John D
authors.initials: JD
authors.lastname: Wade
authors.forename: Frances
authors.initials: F
authors.lastname: Separovic
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity / Q000648:ultrastructure; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020836:Protein Structure, Quaternary
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor