title: [Primary pigmented nodular adrenocortical disease report of 5 cases].
abstract: OBJECTIVE
  To study the pathology, diagnostic and therapeutic method of primary pigmented nodular adrenocortical disease (PPNAD).
  
  
  METHODS
  The data of 5 cases of PPNAD were analyzed retrospectively. Among the 5 cases, 2 were male and 3 were female. The range of age was from 12 to 53 years. All the 5 cases had symptoms of Cushing syndrome. The diagnose depended on the results of endocrine exams, ultrasound, CT, MR and pathological reports. All patients received operation of unilateral adrenalectomy. The therapeutic effects were determined by post-operative results, which concluded clinical symptoms and endocrine exams.
  
  
  RESULTS
  The follow-up time was from 4 months to 3 years. All patients' symptoms of Cushing syndrome were relieved in 6 months after operation. The endocrine exam was normal in one case and obvious improved in the other four cases. Up to now, one patient drop out of the follow-up, the other 4 cases had no evidence of recurrence.
  
  
  CONCLUSIONS
  PPNAD is a rare type of Cushing syndrome. Diagnose depends on endocrine exams and pathological results. Operation is the effective method for the disease.
authors.affiliation: Department of Urology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. zy999916666@sina.com
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yu-xuan
authors.initials: YX
authors.lastname: Wu
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Rui
authors.forename: Ding-yi
authors.initials: DY
authors.lastname: Liu
authors.forename: Wen-long
authors.initials: WL
authors.lastname: Zhou
authors.forename: Rong-ming
authors.initials: RM
authors.lastname: Zhang
authors.forename: Fu-kang
authors.initials: FK
authors.lastname: Sun
authors.forename: Chong-yu
authors.initials: CY
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000315:Adrenalectomy; D000328:Adult; D002648:Child; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010912:Pituitary-Adrenal Function Tests; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed