title: Detection of hibernate myocardium by 99mTc sestamibi gated SPECT during low-dose dobutamine infusion plus nitrate in patients with first acute myocardial infarction.
abstract: OBJECTIVE
  To investigate the role of Tc-MIBI gated SPECT imaging following the administration of low-dose dobutamine plus nitrate (LDD+nitrate) in the assessment of left ventricular function and the perfusion of hibernate myocardial tissue.
  
  
  METHODS
  The study group comprised 29 patients diagnosed as having acute myocardial infarction. In the first month post-infarction, Tc-MIBI gated SPECT imaging was performed in all patients at rest-dobutamine stress and LDD+nitrate. Ejection fraction, end diastolic volume (EDV), end systolic volume (ESV), stroke volume, volume, extent score, and reversibility score values were calculated.
  
  
  RESULTS
  The findings of Tc-MIBI gated SPECT imaging following the administration of LDD+nitrate and the rest Tc-MIBI gated SPECT findings revealed that while the levels of ejection fraction (P=0.004) and reversibility score (P=0.000) increased significantly, there was a significant decrease in EDV (P=0.001), ESV (P=0.001), volume (P=0.017), stroke volume (P=0.257) and extent score (P=0.039) values.
  
  
  CONCLUSIONS
  The use of Tc-MIBI gated SPECT concomitantly with the administration of LDD+nitrate is useful in the determination of myocardial hibernation in patients with left ventricular failure following acute myocardial infarction.
authors.affiliation: Department of Nuclear Medicine, Osmangazi University Medical Faculty, 26480 Eskişehir, Turkey. e_entok@yahoo.com
authors.forename: Emre
authors.initials: E
authors.lastname: Entok
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Cavusoglu
authors.forename: Eser
authors.initials: E
authors.lastname: Kaya
authors.forename: Erkan
authors.initials: E
authors.lastname: Vardareli
authors.forename: Bilgin
authors.initials: B
authors.lastname: Timuralp
mesh_terms: D000328:Adult; D000368:Aged; D004280:Dobutamine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging*; D017682:Myocardial Stunning / Q000150:complications / Q000000981:diagnostic imaging; D009566:Nitrates / Q000008:administration & dosage; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology
chemical_list: D009566:Nitrates; D019275:Radiopharmaceuticals; D004280:Dobutamine; D017256:Technetium Tc 99m Sestamibi