Melting fat away in flies.
Two important proteins that function in regulating cell growth are the transcriptional regulator FOXO and the protein kinase Tor. A recent publication shows that the Melted protein can modulate both FOXO and Tor activity and can also regulate fat levels in Drosophila.
Reis
Tânia
T
Department of Molecular and Cell Biology University of California, Berkeley, California 94720, USA.
Hariharan
Iswar K
IK
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000502:physiology; D051858:Forkhead Transcription Factors; D006801:Humans; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D029721:Drosophila Proteins; C477334:FOXO protein, Drosophila; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; D020794:Receptor Protein-Tyrosine Kinases; C080148:tor protein, Drosophila