Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl)pyridinium.
A new AChE tracer N-[(11)C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2',2'-diphenylpropionoxymethyl)pyridinium ([(11)C]MDDP, [(11)C]1) has been synthesized in 40-65% radiochemical yield. Initial PET dynamic studies of [(11)C]MDDP in rat heart showed rapid heart uptake and blood pool clearance to give high-quality heart images. Blocking studies of [(11)C]MDDP with pretreatment drug neostigmine in rats found only minor reductions in rat heart [(11)C]MDDP retention. The results suggest that [(11)C]MDDP delineates the heart very clearly, and the uptakes of [(11)C]MDDP in rat heart might be related to non-specific binding.
Wang
Ji-Quan
JQ
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Miller
Michael A
MA
Mock
Bruce H
BH
Lopshire
John C
JC
Groh
William J
WJ
Zipes
Douglas P
DP
Hutchins
Gary D
GD
Zheng
Qi-Huang
QH
D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000097:blood / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D049268:Positron-Emission Tomography; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D051381:Rats
C505997:N-(11C)methyl-3-(((dimethylamino)carbonyl)oxy)-2-(2',2'-diphenylpropionoxymethyl)pyridinium; D011726:Pyridinium Compounds; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase