title: Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients.
abstract: OBJECTIVE
  Subjective memory complaints (SMC) and cerebral white-matter lesions (WML) are very prevalent among elderly subjects, but their clinical significance is controversial. The authors sought to determine whether SMCs are related to WML, independently of the presence of depressive symptoms, which are known to be associated with both. The relationship between SMC and cognition was also examined.
  
  
  METHODS
  This is a cross-sectional study on 60 elderly subjects without dementia. All subjects underwent FLAIR and T2-weighted axial MRI scans, a memory-complaint questionnaire, a geriatric depression scale, and a comprehensive cognitive assessment.
  
  
  RESULTS
  Multiple linear regression showed that although the best correlate of SMC was the severity of depressive symptoms, SMC and WML were strongly correlated. Objective cognitive performance was not significantly associated with SMC after adjusting for WML and mood. The presence of a history of late-onset depression was a strong correlate of WML severity, even after adjusting for age, gender, and education.
  
  
  CONCLUSIONS
  Complaints of cognitive decline are significantly associated with the severity of WML, independently of level of cognition and depression.
authors.affiliation: Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK. thaisminett@hotmail.com
authors.forename: Thaís S C
authors.initials: TS
authors.lastname: Minett
authors.forename: Jennie L
authors.initials: JL
authors.lastname: Dean
authors.forename: Michael
authors.initials: M
authors.lastname: Firbank
authors.forename: Philip
authors.initials: P
authors.lastname: English
authors.forename: John T
authors.initials: JT
authors.lastname: O'Brien
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000453:epidemiology; D000647:Amnesia / Q000175:diagnosis* / Q000453:epidemiology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000453:epidemiology; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013223:Statistics as Topic