title: Premature sister chromatid separation in HIV-1-infected peripheral blood lymphocytes.
abstract: To investigate the mechanism of aneuploidy that is frequently observed in AIDS, we examined premature sister chromatid separation (PCS), a sign of genomic instability, in peripheral blood cells of HIV-1-infected individuals. PCS was found in all six HIV-1 individuals at a high incidence. When peripheral blood cells from healthy volunteers were infected with HIV-1 in vitro, the incidence of PCS increased. This suggests that HIV-1 infection causes PCS and has the potential to induce aneuploidy.
authors.affiliation: Department of Intractable Diseases, Research Institute, International Medical Center of Japan, Shinjuku-ku, Tokyo 162-8655, Japan .
authors.forename: Mari
authors.initials: M
authors.lastname: Shimura
authors.forename: Kenzo
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Konishi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sato
authors.forename: Chizuko
authors.initials: C
authors.lastname: Kobayashi
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Ishizaka
mesh_terms: D000782:Aneuploidy; D002478:Cells, Cultured; D002842:Chromatids / Q000235:genetics*; D020090:Chromosome Segregation / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000821:virology*; D008677:Metaphase; D012367:RNA, Viral / Q000097:blood
chemical_list: D012367:RNA, Viral