title: Pulmonary embolism in pemphigus vulgaris, the need for judicious immunotherapy.
abstract: Pemphigus vulgaris is a serious chronic mucocutaneous ailment. In recent decades advances in diagnostic and therapeutic measures have led to a significant decline in morbidity and mortality. However, with the advent of active and prolonged immunotherapy involving corticosteroids, there has been a rise in steroid-associated complications. This has led to significant concern globally over the sensible use of treatment regimen in pemphigus patients. We present a patient who underwent a massive pulmonary embolism following over usage of corticosteroid therapy for pemphigus vulgaris. Whilst the patient survived owing to timely assessment and aggressive surgical intervention, the need for cautious and judicious immunotherapy in pemphigus is emphasized.
authors.affiliation: The Medical College and Section of Cardiothoracic Surgery, Aga Khan University Hospital, Karachi.
authors.forename: Omer
authors.initials: O
authors.lastname: Ashraf
authors.forename: Hasanat
authors.initials: H
authors.lastname: Sharif
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008875:Middle Aged; D010392:Pemphigus / Q000188:drug therapy* / Q000276:immunology; D011655:Pulmonary Embolism / Q000139:chemically induced* / Q000601:surgery
chemical_list: D000305:Adrenal Cortex Hormones