title: Obstetric and perinatal outcome of 1655 ICSI and 3974 IVF singleton and 1102 ICSI and 2901 IVF twin births: a comparative analysis.
abstract: A total of 3974 IVF and 1655 ICSI singleton births and 2901 IVF and 1102 ICSI twin births were evaluated. Pregnancies after both fresh and frozen transfers were included. IVF and ICSI singleton pregnancies were very similar for most obstetric and perinatal variables. The only significant difference was a higher risk for prematurity (< 37 weeks of amenorrhoea) in IVF pregnancies compared with ICSI pregnancies (12.4 versus 9.2%, OR = 1.39, 95% CI = 1.15-1.70). For twin pregnancies, differences were not statistically different except for a higher incidence of stillbirths in the ICSI group (2.08 versus 1.03%, OR = 2.04, 95% CI = 1.14-3.64). Intrauterine growth retardation with or without pregnancy-induced hypertension was observed more often in the ICSI group. Regression analysis of the data with correction for parity and female age showed similar results for twins. For singletons, this analysis showed similar results with the exception of low birth weight babies (< 2500 g), which were also observed more often in IVF pregnancies (9.6 versus 7.9%, OR = 0.79, CI = 0.65-0.98, P = 0.03). This large case-comparative retrospective analysis showed that the obstetric outcome and perinatal health of IVF and ICSI pregnancies is comparable.
authors.affiliation: Scientific Board of the Flemish Society of Obstetrics and Gynecology, Belgium. willem.ombelet@pandora.be
authors.forename: Willem
authors.initials: W
authors.lastname: Ombelet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cadron
authors.forename: Jan
authors.initials: J
authors.lastname: Gerris
authors.forename: Petra
authors.initials: P
authors.lastname: De Sutter
authors.forename: Eugene
authors.initials: E
authors.lastname: Bosmans
authors.forename: Guy
authors.initials: G
authors.lastname: Martens
authors.forename: Gunther
authors.initials: G
authors.lastname: Ruyssinck
authors.forename: Paul
authors.initials: P
authors.lastname: Defoort
authors.forename: Geert
authors.initials: G
authors.lastname: Molenberghs
authors.forename: Wilfried
authors.initials: W
authors.lastname: Gyselaers
mesh_terms: D000328:Adult; D001530:Belgium / Q000453:epidemiology; D002585:Cesarean Section / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008423:Maternal Age; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D014427:Twins