title: Novel inhibitors of the hepatitis C virus NS3 proteinase.
abstract: The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. frank.bennett@spcorp.com
authors.forename: Frank
authors.initials: F
authors.lastname: Bennett
authors.forename: Yi-Tsung
authors.initials: YT
authors.lastname: Liu
authors.forename: Anil K
authors.initials: AK
authors.lastname: Saksena
authors.forename: Ashok
authors.initials: A
authors.lastname: Arasappan
authors.forename: Nancy
authors.initials: N
authors.lastname: Butkiewicz
authors.forename: Bimalendu
authors.initials: B
authors.lastname: Dasmahapatra
authors.forename: John S
authors.initials: JS
authors.lastname: Pichardo
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
authors.forename: Naginbhai M
authors.initials: NM
authors.lastname: Patel
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiaozheng
authors.initials: X
authors.lastname: Yang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D019281:Dimerization; D006526:Hepatitis C / Q000201:enzymology*; D020128:Inhibitory Concentration 50; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000998:Antiviral Agents; D011725:Pyridines; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases