title: [Acute non-herpetic viral encephalitis of juvenile onset: analysis of 11 cases based on initial clinical symptoms].
abstract: We investigated clinical features of juvenile patients presenting non-herpetic viral acute encephalitis (4 men and 7 women, aged of onset; 23.7 +/- 3.3 years) without malignancy and immunodeficiency. We divided the patients into two groups according to initial neurological symptoms: psychiatric symptoms mimicking schizophrenia (group P, n=5), seizure (group S, n=6), and compared clinical manifestations among the two groups. Symptoms frequently seen in initial phase of the illness were neck stiffness (4 cases, 36%), involuntary movement (7 cases, 64%) and convulsion (8 cases, 73%). There were no significant difference among the groups except seizure. Patients in group P had more CSF cells and CSF lymphocytes compared with other groups (p < 0.05 and p < 0.01, respectively). Abnormal intensities in T2-weighted magnetic resonance images were found in 4 cases (36%). The term from the onset to leaving hospital of group P (213 +/- 227 days) was longer than that of group S (98 +/- 85 days), although it did not reach a significant difference. These findings indicate that juvenile acute non-herpetic encephalitis initially presenting psychiatric symptoms was serious and had relatively poor prognosis.
authors.affiliation: Department of Neurology, Kobe City General Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kataoka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kohara
authors.forename: Wakiro
authors.initials: W
authors.lastname: Sato
authors.forename: Manabu
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Michi
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Shinn
authors.initials: S
authors.lastname: Takano
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D020820:Dyskinesias / Q000209:etiology*; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D012559:Schizophrenia / Q000175:diagnosis; D012640:Seizures / Q000209:etiology*