Prognostic factor analysis for plaque psoriasis.
BACKGROUND
Little is known about the long-term prognostic factors which affect clinical outcomes after the diagnosis of psoriasis.


OBJECTIVE
To identify the prognostic factors which predict long-term outcomes after diagnosis.


METHODS
Patients' clinical characteristics at diagnosis were associated with long-term prognosis using the logistic regression method for 169 psoriasis patients (median follow-up time 11.6 years).


RESULTS
The factors age > or =40 [odds ratio 0.27, 95% confidence interval (CI) 0.10-0.72, p = 0.0091], male (odds ratio 2.67, 95% CI 1.02-7.00,p = 0.0459) and BMI > or =25 (odds ratio 2.74, 95% CI 1.01-7.42, p = 0.0480) had significant effects on long-term prognosis after diagnosis. A simple prognostic index based on these factors was proposed.


CONCLUSIONS
Three major prognostic factors were identified. The proposed index may be useful in the design of future clinical trials for psoriasis and in the selection of appropriate therapeutic approaches for individual patients.
Sakai
Rie
R
Department of Pharmacoepidemiology, School of Public Health, Kyoto University, Kyoto, Japan. rsakai@mug.biglobe.ne.jp
Matsui
Shigeyuki
S
Fukushima
Masanori
M
Yasuda
Hideyo
H
Miyauchi
Harumitsu
H
Miyachi
Yoshiki
Y
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D015992:Body Mass Index; D003131:Combined Modality Therapy; D018450:Disease Progression; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011336:Probability; D011379:Prognosis; D011565:Psoriasis / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D018434:Sickness Impact Profile; D013997:Time Factors