Distal renal tubular acidosis: alkali heals osteomalacia and increases net production of 1,25-dihydroxyvitamin D.
In 2 women with distal renal tubular acidosis and osteomalacia, alkali treatment cured the bone disease and was accompanied by marked increases in the serum 1,25 dihydroxyvitamin D concentration, without a significant change in the 25-hydroxyvitamin D concentration.
Wrong
Oliver
O
Royal Free and University College Medical School, London, UK. oliverwrong@compuserve.com
Henderson
Janet E
JE
Kaye
Michael
M
D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000188:drug therapy*; D000328:Adult; D000468:Alkalies / Q000008:administration & dosage*; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007686:Kidney Tubules, Distal / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction; D010018:Osteomalacia / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000097:blood
D000468:Alkalies; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D