title: [Isolated acquired factor VII deficiency in patient with severe head trauma: use of factor VII (factor VII-LFB].
abstract: We report a case of transient acquired and isolated factor VII deficiency associated with severe head trauma. A 16-year-old boy was involved in a motor vehicle accident. CT scan showed frontal brain contusion and a cerebral haematoma (5 cm). First prothrombine time (PT) was normal. Rapidly, a severe coagulopathy developed, unresponsiving to fresh frozen plasma and vitamin K. Haemostatic markers analysis showed an isolated deficiency of factor VII at 15%. No inhibitory activity against factor VII could be detected. We successfully treated the deficiency with intermittent intravenous human factor VII (factor VII-LFB) during 10 days. Factor VII return to normal at 84%. Physiopathological and therapeutic aspects of this rare pathology are presented.
authors.affiliation: Département d'anesthésie-réanimation, HIA Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France. meaudre@club-internet.fr
authors.forename: E
authors.initials: E
authors.lastname: Meaudre
authors.forename: N
authors.initials: N
authors.lastname: Kenane
authors.forename: E
authors.initials: E
authors.lastname: Kaiser
authors.forename: P E
authors.initials: PE
authors.lastname: Gaillard
authors.forename: A
authors.initials: A
authors.lastname: Saillol
authors.forename: E
authors.initials: E
authors.lastname: Cantais
authors.forename: B
authors.initials: B
authors.lastname: Palmier
mesh_terms: D000063:Accidents, Traffic; D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000209:etiology*; D001930:Brain Injuries / Q000150:complications / Q000000981:diagnostic imaging; D020202:Cerebral Hemorrhage, Traumatic / Q000150:complications / Q000000981:diagnostic imaging; D006259:Craniocerebral Trauma / Q000150:complications*; D005167:Factor VII / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D011994:Recombinant Proteins / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII