title: Determinants of prestroke cognitive impairment in stroke associated with small vessel disease.
abstract: Understanding the determinants of prestroke cognitive impairment (PCI) in stroke associated with small vessel disease (SVD) may shed light on how to prevent further cognitive deterioration after stroke. We administered the Informant Questionnaire on Cognitive Decline (IQCODE) to close informants of 78 consecutive stroke patients who had SVD. PCI, as defined by an average score of IQCODE > or =3.4 was found in 19 (24%) patients. Regression analyses were performed on the following risk factors for PCI: age, years of education, gender, previous stroke, volume of white matter changes, measures of silent lacunes, cerebral atrophy index, medial temporal lobe atrophy and frontal lobe atrophy. Multivariate regression analyses revealed that only cerebral atrophy index (OR 1.5, CI 1.2-1.9, p < 0.001) predicted PCI among patients with SVD.
authors.affiliation: Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. vctmok@cuhk.edu.hk
authors.forename: V
authors.initials: V
authors.lastname: Mok
authors.forename: A
authors.initials: A
authors.lastname: Wong
authors.forename: Wai Kwong
authors.initials: WK
authors.lastname: Tang
authors.forename: W W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Yu Hua
authors.initials: YH
authors.lastname: Fan
authors.forename: Polly S
authors.initials: PS
authors.lastname: Richards
authors.forename: K T
authors.initials: KT
authors.lastname: Wong
authors.forename: A T
authors.initials: AT
authors.lastname: Ahuja
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
mesh_terms: D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications / Q000000981:diagnostic imaging / Q000523:psychology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology / Q000523:psychology*; D015140:Dementia, Vascular / Q000000981:diagnostic imaging / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology / Q000523:psychology*; D014057:Tomography, X-Ray Computed