Colorectal cancer: mutations in a signalling pathway.
Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention.
Parsons
D Williams
DW
The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.
Wang
Tian-Li
TL
Samuels
Yardena
Y
Bardelli
Alberto
A
Cummins
Jordan M
JM
DeLong
Laura
L
Silliman
Natalie
N
Ptak
Janine
J
Szabo
Steve
S
Willson
James K V
JK
Markowitz
Sanford
S
Kinzler
Kenneth W
KW
Vogelstein
Bert
B
Lengauer
Christoph
C
Velculescu
Victor E
VE
D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D016133:Polymerase Chain Reaction; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics*
D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases