[2-merkaptobenzenosulfonamides derivates synthesis].
1,3-Dialkyl-2-[2-mercapto-4-R(1)-5-(carboxy- or cyano)benzenesulphonyl]guanidines (Va-g, VI; R(1)=Cl or H) were synthesized by reactions of 3-methylthio-, 3-mercapto- and 3-alkylamino-6-R(1)-7-(carboxy- or cyano)-1,4,2-benzoditiazine-1,1-dioxides with amines. Their oxidation (VII) or methylation products (VIlIa-c, IXa-c) as well novel 3-isobutylamino-6-chloro-7-R-1,4,2-benzodithiazine-1,1-dioxides (II, R=COCl; III, R=CONH2; IV, R=CN) which had been successfully used to the synthesis of compound VI, were also obtained.
Brzozowski
Z
Z
Zakład Technologii Chemicznej Srodków Leczniczych, Akademia Medyczna, ul. K. Marksa 107, 80-416 Gdańsk.
Sławiński
J
J
Borowik
W
W
Gajewski
F
F
D002626:Chemistry, Pharmaceutical; D008745:Methylation; D010084:Oxidation-Reduction; D013449:Sulfonamides / Q000138:chemical synthesis*
D013449:Sulfonamides