title: Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila.
abstract: Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.
authors.affiliation: Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA.
authors.forename: Leesa
authors.initials: L
authors.lastname: LaFever
authors.forename: Daniela
authors.initials: D
authors.lastname: Drummond-Barbosa
mesh_terms: D000818:Animals; D002455:Cell Division; D049109:Cell Proliferation; D004330:Drosophila / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D005502:Food; D005854:Germ Cells / Q000166:cytology*; D007328:Insulin / Q000502:physiology*; D009154:Mutation; D006080:Ovarian Follicle / Q000166:cytology / Q000502:physiology; D010053:Ovary / Q000166:cytology / Q000502:physiology; D010455:Peptides / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology*; D014818:Vitellogenesis
chemical_list: D029721:Drosophila Proteins; D007328:Insulin; D010455:Peptides; C094982:InR protein, Drosophila; D020794:Receptor Protein-Tyrosine Kinases