title: Interference microscopy under double-wavelet analysis: a new approach to studying cell dynamics.
abstract: This Letter combines a novel experimental approach to the study of intracellular processes with a newly developed technique for multimode time-series analysis. Experiments are performed on isolated pond snail (Lymnaea stagnalis) neurons. Local variations in the cellular refractive index as detected by laser interference microscopy are related to the processes in the cell. A wavelet analysis shows the presence of several identifiable modes in the membrane and intracellular dynamics, and a double-wavelet analysis reveals nonlinear interactions between the regulatory processes in the form of mutual frequency and amplitude modulations.
authors.affiliation: Department of Physics, The Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
authors.forename: O V
authors.initials: OV
authors.lastname: Sosnovtseva
authors.forename: A N
authors.initials: AN
authors.lastname: Pavlov
authors.forename: N A
authors.initials: NA
authors.lastname: Brazhe
authors.forename: A R
authors.initials: AR
authors.lastname: Brazhe
authors.forename: L A
authors.initials: LA
authors.lastname: Erokhova
authors.forename: G V
authors.initials: GV
authors.lastname: Maksimov
authors.forename: E
authors.initials: E
authors.lastname: Mosekilde
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D004594:Electrophysiology; D007473:Ion Channels / Q000378:metabolism; D008195:Lymnaea / Q000378:metabolism*; D008857:Microscopy, Interference / Q000379:methods*; D015233:Models, Statistical; D009474:Neurons / Q000378:metabolism*; D009991:Oscillometry; D013997:Time Factors
chemical_list: D007473:Ion Channels