An in vitro study of the interaction of sea-nine with rat liver mitochondria.
The interactions of the antifouling compound Sea-Nine with rat liver mitochondria have been studied. The results indicate that low doses of this compound inhibit adenosine 5'-triphosphate (ATP) synthesis. Further investigations indicate that ATP synthesis inhibition should be due to an interaction of Sea-Nine with the succinic dehydrogenase in the mitochondrial respiratory chain.
Bragadin
Marcantonio
M
Dipartimento di Scienze Ambientali, Università di Venezia, DD 2137, 30123 Venezia, Italy. bragadin@unive.it
Pavoni
Bruno
B
Scutari
Guido
G
Manente
Sabrina
S
D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000818:Animals; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014227:Triazines / Q000378:metabolism*
D014227:Triazines; D000255:Adenosine Triphosphate; D013385:Succinate Dehydrogenase