title: Prevalence and characteristics of noncompliant behaviour and its risk factors in kidney transplant recipients.
abstract: Noncompliance with therapy is one possible explanation for the observation that long-term graft survival is not sufficiently improved by the development in immunosuppression. The aim of the study was to explore the prevalence, characteristics and risk factors of noncompliance with immunosuppression. A total of 161 adult kidney transplant recipients were interviewed about their self-rated health, social support, education, stress from adverse effects and compliance with the immunosuppression. The prevalence of subclinical noncompliance was 54%. Noncompliant patients declared significantly worse self-rated health, less satisfaction with social support and higher stress from adverse effects. Male gender (OR 7.5, CI 2.4-23.39), high stress from adverse effects (OR 12.27, CI 2.44-61.88), fair self-rated health (OR 4.45, CI 1.04-19.55) and fair satisfaction with social support (OR 4.55, CI 1.08-19.24) were predictors of noncompliance. Standardized detection methods should be developed with the aim of identifying patients who are at risk of noncompliance in order to prevent graft loss.
authors.affiliation: Transplantation Department, University Hospital of L. Pasteur, Kosice, Slovak Republic. rosenberger_jaro@hotmail.com
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Rosenberger
authors.forename: Andrea Madarasova
authors.initials: AM
authors.lastname: Geckova
authors.forename: Jitse P
authors.initials: JP
authors.lastname: van Dijk
authors.forename: Iveta
authors.initials: I
authors.lastname: Nagyova
authors.forename: Robert
authors.initials: R
authors.lastname: Roland
authors.forename: Wim J A
authors.initials: WJ
authors.lastname: van den Heuvel
authors.forename: Johan W
authors.initials: JW
authors.lastname: Groothoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors
chemical_list: D007166:Immunosuppressive Agents