Immune regulation of gammadelta T cell responses in mycobacterial infections.
Antigen-specific gammadelta T cells may play a role in anti-mycobacterial immunity. Studies done in humans and animal models have demonstrated complex patterns of gammadelta T cell immune responses during early mycobacterial infections and chronic tuberculosis. Recent studies have also shown a clinical correlation between major recall expansion of antigen-specific gammadelta T cells and immunity against fatal early mycobacterial diseases. Multiple host and microbial factors can regulate diverse immune responses of phosphoantigen-specific gammadelta T cells during mycobacterial infections.
Chen
Zheng W
ZW
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine Chicago, 835 South Wolcott Avenue, MC790, Chicago, IL 60612, USA. zchen@uic.edu
D000818:Animals; D000942:Antigens, Bacterial; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D009161:Mycobacterium / Q000276:immunology; D009164:Mycobacterium Infections / Q000276:immunology*; D010641:Phenotype; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology
D000942:Antigens, Bacterial; D016692:Receptors, Antigen, T-Cell, gamma-delta