title: Selective excitation of myelin water using inversion-recovery-based preparations.
abstract: T1 and T2 relaxation of excised frog sciatic nerve water was characterized at 7 T. Based on these findings, optimal timings for multiple inversion-recovery magnetization preparations were determined to selectively excite the so-called myelin-water T2 component. Subsequent double inversion-recovery and triple inversion-recovery preparations were used in combination with CPMG acquisitions to experimentally determine optimal timings and effect of the preparation. Using double inversion-recovery, optimal timings were found to excite magnetization that is predominantly (approximately 93%) derived from the myelin-water component. Greater selectivity (approximately 96%) was found by extending the preparation to triple inversion-recovery, at the price of decreasing SNR by a factor of approximately 2.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37232-2675, USA.
authors.forename: Adam R
authors.initials: AR
authors.lastname: Travis
authors.forename: Mark D
authors.initials: MD
authors.lastname: Does
mesh_terms: D000818:Animals; D016477:Artifacts; D001834:Body Water / Q000502:physiology*; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009186:Myelin Sheath / Q000502:physiology*; D012584:Sciatic Nerve / Q000033:anatomy & histology*; D014982:Xenopus laevis