title: Clinical characteristics of linezolid-resistant Staphylococcus aureus infections.
abstract: Case reports have previously identified linezolid resistance in 6 clinical isolates of Staphylococcus aureus. We describe an additional case and discuss clinical characteristics of these patients. Invasive procedures, deep organ involvement, and presence of foreign material were predominant in these cases. Resistance followed prolonged (>21 days) linezolid therapy in most cases. The development of resistance to linezolid should be taken into account when selecting this drug as a therapeutic option.
authors.affiliation: School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock, 77555, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Peeters
authors.forename: Juan C
authors.initials: JC
authors.lastname: Sarria
mesh_terms: D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D000069349:Linezolid; D008875:Middle Aged; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid