MyoD and the transcriptional control of myogenesis.
The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner.
Berkes
Charlotte A
CA
Colorado College, Colorado Springs, CO 80903, USA. Charlotte.Berkes@ucsf.edu
Tapscott
Stephen J
SJ
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D024510:Muscle Development / Q000235:genetics / Q000502:physiology*; D017570:MyoD Protein / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D017570:MyoD Protein