title: Frontotemporal dementia with ubiquitinated neuronal inclusions and visuospatial impairment.
abstract: Dementia with ubiquitinated neuronal inclusions has been described only with frontotemporal dementia (FTD). The authors report a patient with progressive FTD accompanied by prominent impairments in visuospatial cognitive functions. Pathology was characterized by ubiquitin-positive intranuclear and cytoplasmic neuronal inclusions. Cortical pathology was widespread and posteriorly accentuated but spared the hippocampal dentate gyrus.
authors.affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Meiner
authors.forename: J P
authors.initials: JP
authors.lastname: Newman
authors.forename: H
authors.initials: H
authors.lastname: Rosenman
authors.forename: D
authors.initials: D
authors.lastname: Soffer
authors.forename: I
authors.initials: I
authors.lastname: Steiner
mesh_terms: D000377:Agnosia / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003704:Dementia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D011597:Psychomotor Performance / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D025801:Ubiquitin