Trashing the genome: the role of nucleases during apoptosis.
Two classes of nucleases degrade the cellular DNA during apoptosis. Cell-autonomous nucleases cleave DNA within the dying cell. They are not essential for apoptotic cell death or the life of the organism, but they might affect the efficiency of the process. By contrast, waste-management nucleases are essential for the life of the organism. In post-engulfment DNA degradation, the DNA of apoptotic cells is destroyed in lysosomes of the cells that have phagocytosed the corpses. Waste-management nucleases also destroy DNA that is released into the extracellular compartment. Here, we describe the complex group of nucleases that are involved in DNA destruction during apoptotic cell death.
Samejima
Kumiko
K
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.
Earnshaw
William C
WC
D017209:Apoptosis / Q000502:physiology*; D003067:Coenzymes; D053938:DNA Fragmentation; D003851:Deoxyribonucleases / Q000737:chemistry / Q000378:metabolism*; D016678:Genome; D006801:Humans; D020287:In Situ Nick-End Labeling; D008958:Models, Molecular; D011487:Protein Conformation
D003067:Coenzymes; D003851:Deoxyribonucleases