title: A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections.
abstract: Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively). We conducted a prospective study of URI and LRI in adults with hematologic malignancies during a 4-year period. We retrospectively tested samples by reverse-transcription polymerase chain reaction for hMPV and analyzed clinical data. Twenty-two (9%) of 251 episodes of respiratory infection tested positive for hMPV. Sixteen (73%) of the illnesses occurred in hematopoietic stem-cell transplant recipients. Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality.
authors.affiliation: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2581, USA. john.williams@vanderbilt.edu
authors.forename: John V
authors.initials: JV
authors.lastname: Williams
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Martino
authors.forename: Núria
authors.initials: N
authors.lastname: Rabella
authors.forename: Magdalena
authors.initials: M
authors.lastname: Otegui
authors.forename: Rocio
authors.initials: R
authors.lastname: Parody
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Heck
authors.forename: James E
authors.initials: JE
authors.lastname: Crowe
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D029121:Metapneumovirus / Q000302:isolation & purification*; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000150:complications / Q000401:mortality / Q000821:virology*; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000150:complications / Q000401:mortality / Q000821:virology*