title: Is progressive osteoarthritis an atheromatous vascular disease?
abstract: Growing evidence from epidemiological studies suggests that osteoarthritis (OA) is linked to atheromatous vascular disease. This hypothesis article proposes that OA, or at least OA structural progression, may be an atheromatous vascular disease of subchondral bone. Further epidemiological studies, imaging investigations of relevant blood vessels, and trials of the effects of statins on the prevention and treatment of OA are needed to examine this hypothesis.
authors.affiliation: Academic Unit of Musculoskeletal Disease, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK. p.conaghan@leeds.ac.uk
authors.forename: P G
authors.initials: PG
authors.lastname: Conaghan
authors.forename: H
authors.initials: H
authors.lastname: Vanharanta
authors.forename: P A
authors.initials: PA
authors.lastname: Dieppe
mesh_terms: D050197:Atherosclerosis / Q000150:complications*; D001842:Bone and Bones / Q000098:blood supply*; D018450:Disease Progression; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D010003:Osteoarthritis / Q000209:etiology* / Q000628:therapy
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors