Palladium-catalyzed one-pot synthesis of highly substituted furans by a three-component annulation reaction.
A new three-component cyclization-coupling reaction catalyzed by palladium was developed, producing polysubstituted furans in good yields from readily available substrates. The reaction conditions and the scope of the process were examined, and a possible mechanism is proposed.
Duan
Xin-hua
XH
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China.
Liu
Xue-yuan
XY
Guo
Li-na
LN
Liao
Meng-chun
MC
Liu
Wei-Min
WM
Liang
Yong-min
YM
D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D005663:Furans; D010165:Palladium