Metachronous metastases from renal cell carcinoma to uterine cervix and vagina: case report and review of literature.
BACKGROUND
Although renal cell carcinoma (RCC) is characterized with unpredictable clinical presentation, multiple genital tract metastases are still surprising and mode of spread is obscure.


METHODS
We report a case of RCC metastases to uterine cervix and vagina 1 year after radical nephrectomy in a 19-year-old virgin. To our knowledge, this case is the second youngest patient with RCC metastasis to vagina, and also third patient with RCC metastasis to uterine cervix.


CONCLUSIONS
Detection of genital lesion may precede diagnosis of RCC. The primary renal tumor was mostly left sided. Retrograde venous extension seems to be the most plausible mode of spread. Limited total experience and variability in therapeutic approach prevent generalizations regarding prognosis, optimal treatment and survival.
Bozaci
Elif Aylin
EA
Ankara University Faculty of Medicine, Department of Obstetrics and Gynecology, Gezegen Sokak No: 7/4, Büyükesat/Ankara, Turkey. eclamptic2000@yahoo.com
Atabekoğlu
Cem
C
Sertçelik
Ayşe
A
Unlü
Cihat
C
Ortaç
Firat
F
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000556:secondary*; D002583:Uterine Cervical Neoplasms / Q000556:secondary*; D014625:Vaginal Neoplasms / Q000556:secondary*