Cherubism associated with neurofibromatosis type 1, and multiple osteolytic lesions of both femurs: a previously undescribed association of findings.
We present a patient with neurofibromatosis type 1, with the clinical, radiological and histological features of cherubism mandibular lesions, and multiple osteolytic, geographic lesions in both femurs, consistent with multiple non-ossifying fibromas. We have been unable to find a similar case in the world literature. We discuss our findings in relationship with a number of syndromes that present clinical, radiological or pathological similarities.
Martínez-Tello
Francisco J
FJ
Departamento de Anatomía Patológica, Hospital Universitario "12 de Octubre", Carretera de Andalucía Km. 5400, 28041, Madrid, Spain. fmartinez.hdoc@salud.madrid.org
Manjón-Luengo
Palmira
P
Martin-Pérez
Manuel
M
Montes-Moreno
Santiago
S
D002636:Cherubism / Q000150:complications* / Q000175:diagnosis; D002648:Child; D003937:Diagnosis, Differential; D005269:Femur; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis; D010014:Osteolysis / Q000175:diagnosis / Q000209:etiology*