title: A Clinico-pathological study on the effect of vincristine on transmissible venereal tumour in dogs.
abstract: Transmissible venereal tumour (TVT) is a coitally transmitted neoplasm of dogs and is common among sexually active dogs, where sexual behaviour is not under control. Several treatment options are available for the treatment of the tumour, with chemotherapy being the most commonly employed. In this study, we investigated the clinical and cytological changes after weekly vincristine sulphate administration in 38 cases of naturally occurring TVT. Tumours totally regressed in 31 dogs after two to seven doses (mean 3.54 +/- 1.01) of vincristine. One dog died after the fifth dose of vincristine, and in six dogs, an additional treatment with doxorubicin was needed. Masses were still present in four dogs and the histopathological examination revealed small nodules of granulation tissue in two dogs, while viable tumour cells were identified in the remaining two cases. No recurrences were observed in a follow-up period of 7-49 months (mean 13.64 +/- 9.66); in one dog, granulation tissue was detected in the surgery site after 2 months. Treatment success could easily be followed by the cytological changes. In conclusion, vincristine was found to be effective chemotherapeutic agent.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Bursa, Turkey. dnak@uludag.edu.tr
authors.forename: D
authors.initials: D
authors.lastname: Nak
authors.forename: Y
authors.initials: Y
authors.lastname: Nak
authors.forename: I T
authors.initials: IT
authors.lastname: Cangul
authors.forename: B
authors.initials: B
authors.lastname: Tuna
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy* / Q000473:pathology; D005832:Genital Diseases, Male / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D016896:Treatment Outcome; D014685:Venereal Tumors, Veterinary / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine