title: Cognitive predictors of psychosocial functioning outcome in schizophrenia: a follow-up study of subjects participating in a rehabilitation program.
abstract: The aims of this prospective study were to explore in subjects with psychosis participating in a rehabilitation program whether cognitive performances at baseline predicted (i) psychosocial functioning over a 15-16 month follow-up; (ii) improvement in psychosocial functioning over the rehabilitation program. Visuo-spatial tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were administered to assess cognitive performance in 55 subjects with schizophrenia spectrum disorders who completed a rehabilitation program. The Multnomah Community Ability Scale (MCAS) was used to measure dimensions of community functioning. One subscale of the Client's Assessment of Strengths, Interests, and Goals (CASIG) provided a measure of subjective quality of life (QoL). Improvement was defined as a 15% or more increase in psychosocial scores between baseline and follow-up. Worse baseline sustained attention predicted better self-rated quality of life, and better baseline visual memory predicted better community functioning over the rehabilitation follow-up period, in particular, higher autonomy in activities of daily living, and less physical and psychiatric symptoms that could interfere with rehabilitation. Baseline cognitive performances predicted community functioning improvement during the follow-up period: visual memory predicted improvement in daily living autonomy and in social competence; sustained attention predicted improvement in behavioral problems (such as medication compliance, collaboration with treatment providers or impulse control) and social competence; planning performances predicted improvement in social competence. These cognitive functions could be specifically targeted in a rehabilitation program aimed at enhancing functioning in those particular dimensions.
authors.affiliation: INSERM U657 & JE 2358, IFR of Public Health, University Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France.
authors.forename: Antoinette
authors.initials: A
authors.lastname: Prouteau
authors.forename: Hélène
authors.initials: H
authors.lastname: Verdoux
authors.forename: Catherine
authors.initials: C
authors.lastname: Briand
authors.forename: Alain
authors.initials: A
authors.lastname: Lesage
authors.forename: Pierre
authors.initials: P
authors.lastname: Lalonde
authors.forename: Luc
authors.initials: L
authors.lastname: Nicole
authors.forename: Daniel
authors.initials: D
authors.lastname: Reinharz
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Stip
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011379:Prognosis; D011788:Quality of Life; D012559:Schizophrenia / Q000175:diagnosis* / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D012917:Social Adjustment