title: [In vitro antifungal activity of voriconazole against dermatophytes and superficial isolates of Scopulariopsis brevicaulis].
abstract: We have studied the in vitro antifungal activity of voriconazole, fluconazole and itraconazole against 252 clinical isolates of dermatophytes and Scopulariopsis brevicaulis by a standardized agar diffusion method (NeoSensitabs). Several important factors such as temperature (28 degrees C vs. 35 degrees C) and incubation time (2-10 days vs. 18-74 h) were adapted to dermatophytes and Scopulariopsis requirements. Voriconazole showed an excellent activity against most species of dermatophytes, higher than itraconazole and fluconazole. However, S. brevicaulis isolates were highly resistant to all azoles used in this study. Voriconazole might be an interesting antifungal alternative to refractory superficial mycoses.
authors.affiliation: Departamento de Microbiología, ACIA, Apartado Postal 10178, E-08080, Barcelona, Spain. acarrillo@ya.com
authors.forename: Alfonso Javier
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: Carmen Delia
authors.initials: CD
authors.lastname: Cárdenes
authors.forename: Bartolomé
authors.initials: B
authors.lastname: Carrillo-Orive
authors.forename: Virginia
authors.initials: V
authors.lastname: Rodríguez
authors.forename: Osacr
authors.initials: O
authors.lastname: Del Valle
authors.forename: José Bou
authors.initials: JB
authors.lastname: Casals
authors.forename: Pilar Ariadna
authors.initials: PA
authors.lastname: Ezkurra
authors.forename: Guillermo
authors.initials: G
authors.lastname: Quindós
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000302:isolation & purification; D001203:Ascomycota / Q000187:drug effects* / Q000302:isolation & purification; D003881:Dermatomycoses / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D026141:Drug Resistance, Multiple, Fungal; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; D065819:Voriconazole