title: B-cell lymphoma of the larynx in a patient with rheumatoid arthritis.
abstract: We report a case of B-cell lymphoma with the larynx as the primary site of presentation in a rheumatoid arthritis patient previously treated with methotrexate. Primary non-Hodgkin's lymphoma (NHL) of the larynx is rare. There may be an increased risk of lymphoma in patients with rheumatoid arthritis, with an even higher risk in those patients treated with methotrexate. The diagnostic and treatment options are discussed.
authors.affiliation: Department of Otolaryngology, Radcliffe Infirmary, Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Patiar
authors.forename: J D
authors.initials: JD
authors.lastname: Ramsden
authors.forename: A P
authors.initials: AP
authors.lastname: Freeland
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D018501:Antirheumatic Agents; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate