title: The prognostic value of the expression of Bcl-2, p53 and LMP-1 in patients with Hodgkin's lymphoma.
abstract: This study was undertaken to evaluate the clinical significance of the expression of Bcl-2, p53 and LMP-1 in Hodgkin and Reed - Sternberg cells of patients with Hodgkin's lymphoma. The expression of these proteins in pre-treatment tissue biopsy specimens was correlated with presenting clinical features, failure-free survival (FFS) and overall survival (OS) in 83 patients with a confirmed Hodgkin's lymphoma treated in a single institution. HIV-positive patients were excluded. Patients were classified according to the International Prognostic Score (IPS) in low-risk (0 - 2 factors) and high-risk groups. The median age was 41 years (15 - 84), 41% were women, and 93% had advanced-stage disease (IIB - IVB). The expression of Bcl-2, p53 and LMP-1 was not associated with the complete remission rate, FFS or OS. The IPS risk group was the only factor significantly associated with OS. Patients with a high IPS had a lower 5 year OS (43% vs. 79%, P = 0.003). The expression of Bcl-2, p53 and LMP-1 did not add prognostic information to the IPS.
authors.affiliation: Hematology Service, School of Medicine and University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. spector@ufri.br
authors.forename: Nelson
authors.initials: N
authors.lastname: Spector
authors.forename: Cristiane Bedran
authors.initials: CB
authors.lastname: Milito
authors.forename: Irene
authors.initials: I
authors.lastname: Biasoli
authors.forename: Ronir Raggio
authors.initials: RR
authors.lastname: Luiz
authors.forename: Wolmar
authors.initials: W
authors.lastname: Pulcheri
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Morais
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D000328:Adult; D000368:Aged; D003598:Cytoskeletal Proteins; D005260:Female; D015870:Gene Expression; D016158:Genes, p53; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D060588:LIM Domain Proteins; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; C484380:PDLIM7 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2