title: Chromophoric binaphthyl derivatives.
abstract: A short synthetic route is outlined, starting from bromo-BN derivatives, via halogen lithium exchange, subsequent Michael reaction with dimethylaminoacrolein, hydrolysis to the corresponding aldehyde, and final condensation with a benzothiazolium unit to produce a BN-pentamethinium system, which absorbs in the visible range around 450 nm. Enantiopure ligands show a decent Cotton effect in the CD spectrum. Preliminary data show potential of these compounds in the area of supramolecular chemistry (enantioselective recognition) and also for medicinal application (induction of apoptosis). [reaction: see text]
authors.affiliation: Department of Analytical Chemistry Technická 5, Institute of Chemical Technology, CZ-166 28, Prague 6, Czech Republic.
authors.forename: Tomás
authors.initials: T
authors.lastname: Bríza
authors.forename: Zdenĕk
authors.initials: Z
authors.lastname: Kejík
authors.forename: Petr
authors.initials: P
authors.lastname: Vasek
authors.forename: Jarmila
authors.initials: J
authors.lastname: Králová
authors.forename: Pavel
authors.initials: P
authors.lastname: Martásek
authors.forename: Ivana
authors.initials: I
authors.lastname: Císarová
authors.forename: Vladimír
authors.initials: V
authors.lastname: Král
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002384:Catalysis; D002942:Circular Dichroism; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006842:Hydrocarbons, Brominated; D009281:Naphthalenes