title: [HLA class I and II polymorphism and haplotypes in Guangdong Han population].
abstract: OBJECTIVE
  To analyze the polymorphism and haplotypes of HLA class I and II in Guangdong Han population and detect the HLA-A, B, Cw and DRB1 allele frequencies.
  
  
  METHODS
  An auto semi-quantitative PCR-sequence speacific oligonucleotide probe(PCR-SSOP) method was adopted in exploring the HLA-A, B, Cw and DRB1 genotypes of the samples from 160 bone marrow donors.
  
  
  RESULTS
  Twelve HLA-A, 23 B, 11 Cw and 13 DRB1 alleles were obtained. A total of 9 HLA-A-B, 20 Cw-B, 7 A-Cw, and 8 A-DRB1, 9 B-DRB1, 10 Cw-DRB1 haplotypes were found.
  
  
  CONCLUSIONS
  HLA class I and II alleles in Guangdong Han population have plenty of polymorphisms. The haplotype distribution possesses territory characteristic.
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282 PR China.
authors.forename: Hong-jing
authors.initials: HJ
authors.lastname: Ma
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Yin
authors.forename: Kun-yuan
authors.initials: KY
authors.lastname: Guo
authors.forename: Lu-lu
authors.initials: LL
authors.lastname: Xiao
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens