title: Production of the radioactive antitumoral cisplatin.
abstract: This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
authors.affiliation: Division for Radiation Technology, Nuclear Technology Development Centre (CDTN)/National Commission for Nuclear Energy (CNEN), P.O. Box 941, CEP 30123-970, Belo Horizonte, Minas Gerais, Brazil. asleal@sdtn.br
authors.forename: Alexandre S
authors.initials: AS
authors.lastname: Leal
authors.forename: Alvaro D
authors.initials: AD
authors.lastname: Carvalho Júnior
authors.forename: Fabiana M
authors.initials: FM
authors.lastname: Abrantes
authors.forename: Maria Angela de B C
authors.initials: MA
authors.lastname: Menezes
authors.forename: Vany
authors.initials: V
authors.lastname: Ferraz
authors.forename: Tamara S
authors.initials: TS
authors.lastname: Cruz
authors.forename: Valbert N
authors.initials: VN
authors.lastname: Cardoso
authors.forename: Mônica C
authors.initials: MC
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000528:radiation effects*; D002104:Cadmium / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002945:Cisplatin / Q000493:pharmacokinetics / Q000528:radiation effects*; D010984:Platinum / Q000528:radiation effects*; D011868:Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D011868:Radioisotopes; D002104:Cadmium; D010984:Platinum; D002945:Cisplatin