title: Altered iron metabolism, transferrin receptor 1 and ferritin in patients with colon cancer.
abstract: In this study, the level and distribution of transferrin receptor 1 (TfR1) and ferritin in colorectal carcinoma and in normal colon epithelium has been determined relative to the tumor stage and iron status of patients using immunohistochemical staining methods. While the majority of carcinoma patients were anemic, no relationship between the level of colon tissue ferritin and TfR1 and the systemic parameters of iron metabolism was evident. Furthermore, no association between ferritin content and the grade of colorectal carcinoma was observed. However, a relationship between the expression of TfR1 and the grade of colorectal carcinoma was observed. In this case high expression of TfR1 was found in colorectal carcinoma samples of Dukes A or B grade, and well differentiated colorectal carcinoma cells. In comparison, weak or no expression of TfR1 was observed in carcinoma samples of Dukes C or D grade with poorly differentiated cells and in carcinoma samples that had lymph node infiltration and distant metastasis.
authors.affiliation: University of Zagreb, Medical School, Zagreb, Croatia.
authors.forename: Maja
authors.initials: M
authors.lastname: Prutki
authors.forename: Marija
authors.initials: M
authors.lastname: Poljak-Blazi
authors.forename: Marko
authors.initials: M
authors.lastname: Jakopovic
authors.forename: Davor
authors.initials: D
authors.lastname: Tomas
authors.forename: Igor
authors.initials: I
authors.lastname: Stipancic
authors.forename: Neven
authors.initials: N
authors.lastname: Zarkovic
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D003106:Colon / Q000737:chemistry; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D005293:Ferritins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011990:Receptors, Transferrin / Q000032:analysis*
chemical_list: D015703:Antigens, CD; C068126:CD71 antigen; D011990:Receptors, Transferrin; D005293:Ferritins; D007501:Iron