Phloroglucinol for acceleration of labour: double blind, randomized controlled trial.
OBJECTIVE
To determine the effects of Phloroglucinol in acceleration of labour and its adverse effects on mother and foetus.


METHODS
A double blind randomized, placebo controlled trial was conducted on 100 patients in active phase of uncomplicated labour selected by convenient sampling. Patients were given Phloroglucinol or Placebo (distilled water) intravenously. Progress of labour was plotted on Partogram. Any adverse effects of the drug on mother and fetus were noted. Student's t-test was applied for statistical analysis.


RESULTS
In patients receiving Phloroglucinol there was a mean 34% reduction in duration of 1st stage of labour and a mean 23% reduction in 2nd stage as compared to Placebo group respectively. Blood loss >500ml was observed in 2% patients. Otherwise there were no adverse effects on mother or foetus.


CONCLUSIONS
Phloroglucinol shortens the duration of labour, is non toxic to both mother and fetus and does not cause primary post partum haemorrhage.
Tabassum
Samia
S
Department of Obstetrics and Gynaecology, Khyber Teaching Hospital, Peshawar.
Tabassum
Samina
S
Afridi
Bilqis
B
Aman
Zahid
Z
D005260:Female; D006801:Humans; D007745:Labor Onset / Q000187:drug effects*; D007747:Labor Stage, First / Q000187:drug effects; D007748:Labor Stage, Second / Q000187:drug effects; D007749:Labor Stage, Third / Q000187:drug effects; D007743:Labor, Obstetric / Q000187:drug effects*; D010276:Parasympatholytics / Q000009:adverse effects / Q000627:therapeutic use*; D010696:Phloroglucinol / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D006473:Postpartum Hemorrhage / Q000139:chemically induced; D011247:Pregnancy; D013997:Time Factors
D010276:Parasympatholytics; D010919:Placebos; D010696:Phloroglucinol