title: Multiphase hemodynamic simulation of pulsatile flow in a coronary artery.
abstract: A multiphase transient non-Newtonian three-dimensional (3-D) computational fluid dynamics (CFD) simulation has been performed for pulsatile hemodynamics in an idealized curved section of a human coronary artery. We present the first prediction, to the authors' knowledge, of particulate buildup on the inside curvature using the multiphase theory of dense suspension hemodynamics. In this study, the particulates are red blood cells (RBCs). The location of RBC buildup on the inside curvature correlates with lower wall shear stress (WSS) relative to the outside curvature. These predictions provide insight into how blood-borne particulates interact with artery walls and hence, have relevance for understanding atherogenesis since clinical observations show that atherosclerotic plaques generally form on the inside curvatures of arteries. The buildup of RBCs on the inside curvature is driven by the secondary flow and higher residence times. The higher viscosity in the central portion of the curved vessel tends to block their flow, causing them to migrate preferentially through the boundary layer. The reason for this is the nearly neutrally buoyant nature of the dense two-phase hemodynamic flow. The two-phase non-Newtonian viscosity model predicts greater shear thinning than the single-phase non-Newtonian model. Consequently, the secondary flow induced in the curvature is weaker. The waveforms for computed hemodynamic parameters, such as hematocrit, WSS, and viscosity, follow the prescribed inlet velocity waveforms. The lower oscillatory WSS produced on the inside curvature has implications for understanding thickening of the intimal layer.
authors.affiliation: Argonne National Laboratory, Energy Technology Division, Argonne, IL 60439-4815, USA.
authors.forename: Jonghwun
authors.initials: J
authors.lastname: Jung
authors.forename: Robert W
authors.initials: RW
authors.lastname: Lyczkowski
authors.forename: Chandrakant B
authors.initials: CB
authors.lastname: Panchal
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hassanein
mesh_terms: D001696:Biomechanical Phenomena; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D018056:Hemorheology; D008954:Models, Biological; D011674:Pulse; D033081:Shear Strength