title: Hydrogen peroxide mouth rinse: an analgesic post-tonsillectomy.
abstract: OBJECTIVE
  To compare the analgesic efficacy of hydrogen peroxide (H2O2) mouth rinse with control for post-tonsillectomy pain management.
  
  
  METHODS
  Double-blinded, prospective, randomized, controlled clinical trial.
  
  
  METHODS
  Thirty-seven patients from 5 to 14 years old undergoing electrocautery tonsillectomy were randomized to either the H2O2 mouth rinse or the water rinse (control) group. For 14 days, patients recorded pain levels twice daily using a visual analogue scale. Analgesic uses, as well as any complications, were also noted by the patients.
  
  
  RESULTS
  Thirty-seven patients completed the study, 21 in the treatment group and 16 in the control group. Mean postoperative days of pain were 10.3 and 8.3, respectively, and differed significantly (p = .008). Mean postoperative days of analgesic use were 9.0 and 6.7, respectively, and differed significantly (p = .005). Only one incidence of postoperative hemorrhage occurred in the study group.
  
  
  CONCLUSIONS
  In our study, the H2O2 mouth rinse does not provide a better analgesic effect than the water rinse for post-tonsillectomy pain relief.
authors.affiliation: Division of Otolaryngology, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec.
authors.forename: Zahi Abou
authors.initials: ZA
authors.lastname: Chacra
authors.forename: John J
authors.initials: JJ
authors.lastname: Manoukian
authors.forename: Khaled
authors.initials: K
authors.lastname: Al-Qahtani
authors.forename: Mohamed
authors.initials: M
authors.lastname: Al-Eisa
authors.forename: Rick
authors.initials: R
authors.lastname: Balys
authors.forename: Abderrahman
authors.initials: A
authors.lastname: Hagr
authors.forename: Ted L
authors.initials: TL
authors.lastname: Tewfik
authors.forename: Melvin D
authors.initials: MD
authors.lastname: Schloss
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use*; D008297:Male; D009067:Mouthwashes; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D014068:Tonsillectomy
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D006861:Hydrogen Peroxide