title: Risperidone reduces aggression in boys with a disruptive behaviour disorder and below average intelligence quotient: analysis of two placebo-controlled randomized trials.
abstract: The present study aimed to analyse the effect of risperidone on a priori defined core aggression items. Data were pooled from 163 boys (aged 5-12 years, with or without comorbid attention-deficit/hyperactivity disorder) with a DSM-IV diagnosis of either conduct disorder or oppositional defiant disorder who had participated in either of two identical, 6-week, randomized, double-blind, placebo-controlled trials. All received treatment with either placebo or oral risperidone solution (0.01-0.06 mg/kg/day). Subjects had below average intelligence [intelligence quotient (IQ) 36-84] and a score of > or =24 on the Conduct Problem subscale of the Nisonger Child Behaviour Rating Form (N-CBRF). An expert advisory panel selected six core aggression items from the N-CBRF, from which a total Aggression Score (AS, range 0-18) was constructed. Compared to those treated with placebo, risperidone-treated subjects experienced significantly greater mean decreases from baseline in the AS at each of weeks 1-6 (P<0.001). By study endpoint, aggression among risperidone-treated subjects had declined by 56.4% (mean baseline AS 10.1; mean endpoint AS 4.4), which was more than twice that of placebo-treated subjects (mean baseline AS 10.6; mean endpoint AS 8.3; 21.7% reduction). Risperidone was efficacious in reducing symptoms of aggression in boys of below average IQ with disruptive behaviour disorders.
authors.affiliation: Department of Pediatrics, Psychiatry, Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada. john.leblanc@dal.ca
authors.forename: John C
authors.initials: JC
authors.lastname: LeBlanc
authors.forename: Carin E
authors.initials: CE
authors.lastname: Binder
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Armenteros
authors.forename: Michael G
authors.initials: MG
authors.lastname: Aman
authors.forename: Jenny S
authors.initials: JS
authors.lastname: Wang
authors.forename: Huong
authors.initials: H
authors.lastname: Hew
authors.forename: Vivek
authors.initials: V
authors.lastname: Kusumakar
mesh_terms: D000374:Aggression / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D019955:Conduct Disorder / Q000188:drug therapy* / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D006801:Humans; D007360:Intelligence; D008297:Male; D010919:Placebos; D018967:Risperidone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D010919:Placebos; D018967:Risperidone