title: Disorders of eating behavior: correlation between hypothalamo-pituitary-thyroid function and psychopathological aspects.
abstract: Altered pituitary-thyroid (PT) function (TSH, FT4, FT3 plasma levels) was correlated with symptoms of Eating Disorders (ED) in 137 patients (65 ANR, 12 ANP, 19 ANBP, 26 BN, 8 EDNOS-AN, 7 EDNOS-BN) and 30 controls. PT hormone concentrations were assessed by immunofluorimetry and psychopathology by EDI-2 and HSCL-90. Values of TSH were decreased in ANP, BN, EDNOS-AN, of T4 in ANR, ANP, AN-BP, of T3 in ANR, ANP, ANBP, BN, EDNOS-AN, EDNOS-BN. TSH values correlated negatively with ineffectiveness in BN and EDNOS-AN, and with depression in EDNOS-AN. FT4 values correlated positively with perfectionism in ANR, ANP and ANBP, with interoceptive awareness in EDNOS-AN, and negatively with depression in EDNOS-AN and with body dissatisfaction in EDNOS-BN. FT3 values correlated positively with perfectionism in ANBP and BN, with ineffectiveness in ANR and ANP, with depression in EDNOS-AN, with hostility in ANR and EDNOS-BN, with interpersonal sensibility in ANP, with somatization in EDNOS-BN, and negatively with interpersonal distrust in EDNOS-AN. Prospective studies are needed to confirm whether or not altered PT parameters correlate with ED symptoms during the course of the diseases.
authors.affiliation: Mental Health Department, Center for Study and Treatment of Eating Disorders, L. Sacco Hospital, Milan 20129, Italy. francesca.brambilla4@tin.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Brambilla
authors.forename: Paolo
authors.initials: P
authors.lastname: Santonastaso
authors.forename: Lorenza
authors.initials: L
authors.lastname: Caregaro
authors.forename: Angela
authors.initials: A
authors.lastname: Favaro
mesh_terms: D000328:Adult; D000855:Anorexia / Q000503:physiopathology / Q000523:psychology; D015992:Body Mass Index; D002032:Bulimia / Q000503:physiopathology / Q000523:psychology; D001068:Feeding and Eating Disorders / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D001523:Mental Disorders / Q000503:physiopathology* / Q000523:psychology*; D010901:Pituitary Function Tests; D011569:Psychiatric Status Rating Scales; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones