title: [Biological properties of HIV-1 variants circulating among drug users in Russia].
abstract: Human immunodeficiency virus type 1 variants belonging to subtype A, as well as recombinant gaga/engvB variants, derived from HIV-infected patients living in the Moscow and Perm Regions, were isolated and characterized. Intravenous administration of psychoactive drugs was a major risk factor of the infection for all the patients. All the examined isolates of HIV-1 types A and A/B were shown to be characterized by a low virus-specific activity and to be used as secondary CCR5 and CXCR4 protein receptors. The findings suggest that the domination of subtype A variant in this risk group is unassociated with fundamental differences in biological properties between the isolates of this subtype and recombinant viruses.
authors.forename: T A
authors.initials: TA
authors.lastname: Khanina
authors.forename: L M
authors.initials: LM
authors.lastname: Selimova
authors.forename: E V
authors.initials: EV
authors.lastname: Kazennikova
authors.forename: A F
authors.initials: AF
authors.lastname: Bobkov
authors.forename: M R
authors.initials: MR
authors.lastname: Bobkova
authors.forename: V V
authors.initials: VV
authors.lastname: Pokrovskiĭ
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Zverev
authors.forename: R
authors.initials: R
authors.lastname: Braganza
authors.forename: K
authors.initials: K
authors.lastname: Nicolson
authors.forename: D
authors.initials: D
authors.lastname: Weber
mesh_terms: D000595:Amino Acid Sequence; D005260:Female; D015752:Genes, env / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D012426:Russia / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000821:virology*