title: Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanning.
abstract: A novel approach for concurrent measurement of regional cerebral blood flow (CBF) and regional cerebral metabolic rate for glucose consumption (CMRGlc) in humans is proposed and validated in normal subjects during visual stimulation. 18F-labeled fluorodeoxyglucose was administered during the measurement of CBF by continuous arterial spin labeled magnetic resonance imaging (MRI). Subsequent positron emission tomographic (PET) scanning demonstrated the distribution of labeled deoxyglucose during the MRI acquisition. An excellent concordance between regional CBF and regional CMRGlc during visual stimulation was found, consistent with previously published PET findings. Although initially validated using a brief, non-quantitative protocol, this approach can provide quantitative CBF and CMRGlc, with a broad range of potential applications in functional physiology and pathophysiology.
authors.affiliation: Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA. andrew.newberg@uphs.upenn.edu
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Newberg
authors.forename: Jiongjiong
authors.initials: J
authors.lastname: Wang
authors.forename: Hengyi
authors.initials: H
authors.lastname: Rao
authors.forename: Randel L
authors.initials: RL
authors.lastname: Swanson
authors.forename: Nancy
authors.initials: N
authors.lastname: Wintering
authors.forename: Joel S
authors.initials: JS
authors.lastname: Karp
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
authors.forename: Joel H
authors.initials: JH
authors.lastname: Greenberg
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
mesh_terms: D000465:Algorithms; D001786:Blood Glucose; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D010101:Oxygen Consumption / Q000502:physiology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology
chemical_list: D001786:Blood Glucose; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose