title: Synthesis and anti-cancer activity of dinuclear platinum(II) complexes containing bis(thioalkyl)dicarba-closo-dodecaborane(12) ligands.
abstract: A series of novel, dinuclear (2,2':6',2''-terpyridine)platinum(ii) complexes containing bis(thioalkyl)-dicarba-closo-dodecaborane(12)(carborane) ligands were prepared and characterised, and their preliminary anti-cancer characteristics have been determined in vitro; the complexes are the first examples of bis-intercalator complexes containing a boron-rich carborane cage.
authors.affiliation: School of Chemistry and Physics, The University of Adelaide, Adelaide, South Australia 5005, Australia.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Woodhouse
authors.forename: Erin J
authors.initials: EJ
authors.lastname: Ziolkowski
authors.forename: Louis M
authors.initials: LM
authors.lastname: Rendina
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001880:Boranes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy; D008024:Ligands; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001880:Boranes; D008024:Ligands; D017671:Platinum Compounds