[Immunological interactions in different forms of coronary heart disease].
The study included measurement of serum levels of IL-1beta, IL-2, IL-6, IL-8, and TNF-alpha, as well as the expression of mRNA IL-1beta, IL-2, IL-6, and TGfb1 in the vascular wall of patients with coronary atherosclerosis (angina, myocardial infarction). IL-1beta, IL-2, IL-6, IL-8, and TNF-alpha serum levels in patients with coronary atherosclerosis were found to significantly higher than those in healthy individuals (control group). Detection of IL-1beta, IL-2, IL-6, and TGFb1 in tissues revealed mRNA of the cytokines under study in radial artery wall. The main aortic cytokine was found to be IL-2 (7 samples out of 8); the main cytokines in peripheral arteries were IL-1beta and IL-6 (5 samples out of 8). The results show that elevation of IL-1beta, IL-2, and IL-8 in patients with coronary atherosclerosis demonstrates an immunoinflammatory nature of the disease; the detection of dissimilar cytokines in tissue samples reflects not only different degree of vessel involvement, but also a phase character of the process.
Mazurov
V I
VI
Veber
V V
VV
Stolov
S V
SV
Zaraĭskiĭ
M I
MI
D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology*; D010641:Phenotype; D012307:Risk Factors; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers; D016207:Cytokines