title: [Expressions of tumor necrosis factor receptor I and II in human gastric carcinoma].
abstract: OBJECTIVE
  To study the clinical significance of expressions of tumor necrosis factor receptor I and II(TNFR I and II) and their relationship with clinical pathology in human gastric carcinoma.
  
  
  METHODS
  SABC immunohistochemical method was used to examine the expressions of TNFR I and II in 51 cases of gastric carcinoma, 41 adjacent mucosal and 15 normal gastric mucosa tissues.
  
  
  RESULTS
  The positivity rates of TNFR I and II expressions in human gastric carcinoma were significantly higher than those in the adjacent mucosal and normal mucosal tissues, and their expressions were significantly higher in the surrounding mucosa than in the normal tissues. In gastric carcinoma tissues, no correlations of TNFR I and II expressions with serous membrane invasion or lymph node metastasis were found, but the differentiation grade was positively correlated with TNFR expressions (r=-0.3111, P=0.035; r=-0.5952, P=0.000, respectively).
  
  
  CONCLUSIONS
  TNFR I and II expressions are valuable indicators for determining the malignancy and predicting the differentiation grade of gastric carcinoma.
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.forename: Lan
authors.initials: L
authors.lastname: Bai
authors.forename: Qing-zhen
authors.initials: QZ
authors.lastname: Nan
authors.forename: Li-shan
authors.initials: LS
authors.lastname: Cai
authors.forename: Jian-chang
authors.initials: JC
authors.lastname: Cui
authors.forename: Jiu-long
authors.initials: JL
authors.lastname: Dai
authors.forename: Yong
authors.initials: Y
authors.lastname: Lin
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000096:biosynthesis*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II