title: Reversal of hepatoma cells resistance to anticancer drugs is correlated to cell proliferation kinetics, telomere length and telomerase activity.
abstract: BACKGROUND
  Clinical and experimental observations indicate that resistance to anticancer drugs may be spontaneously reversible over time.
  
  
  METHODS
  This work is a mathematical and statistical analysis of the relationship, during a 9-month experiment, between the resistance of repeatedly re-seeded hepatoma cells to methotrexate (MTX) or to cisplatin (cisP) and untreated cell proliferation, telomere length and telomerase activity.
  
  
  RESULTS
  All variables showed complex oscillations, as previously published. In this work, cell proliferation was modelized by the logistic model, and the proliferation rates (a-values) together with their variations (va-values) were calculated.
  
  
  CONCLUSIONS
  Significant correlations were discovered between cell resistance to treatments and a-values, va-values, telomere length and telomerase activities. These results open new insights into the handling of chemotherapy in the treatment of cancers.
authors.affiliation: Equipe Biomath-Biostat, Université Paris 7-Denis Diderot, 2 place Jussieu, 75251 Paris, France.
authors.forename: Nguyen Phong
authors.initials: NP
authors.lastname: Chau
authors.forename: Jean
authors.initials: J
authors.lastname: Deschatrette
authors.forename: Claire
authors.initials: C
authors.lastname: Wolfrom
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D048708:Cell Growth Processes / Q000502:physiology; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016015:Logistic Models; D008727:Methotrexate / Q000494:pharmacology*; D011237:Predictive Value of Tests; D051381:Rats; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D019098:Telomerase; D002945:Cisplatin; D008727:Methotrexate