title: Seven new meroditerpenoids, from the marine sponge Strongylophora strongylata, that inhibited the maturation of starfish oocytes.
abstract: Seven new meroditerpenoids, strongylophorines 13-19 (1-7), have been isolated together with the four known strongylophorines 2 (8), 3 (9), 4 (10), and 8 (11) by a screening method using oocytes of the starfish Asterina pectinifera from a marine sponge Strongylophora strongylata collected at Iriomote Island, Okinawa, Japan. The structures were assigned according to their spectral data. Ten strongylophorines inhibited the maturation of starfish oocytes in the range 1.1-37.6 microM (IC50), while strongylophorine 4 (10) was not active at 250 microM.
authors.affiliation: Department of Ocean Sciences, Tokyo University of Fisheries, Konan, Minato-ku, Tokyo, 108-8477, Japan.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Akano
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagai
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development*; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis; D013215:Starfish / Q000196:embryology
chemical_list: D004224:Diterpenes