title: Extensive pneumothorax, pneumomediastinum and surgical emphysema as a complication of bleomycin therapy.
abstract: Bleomycin is a commonly used chemotherapeutic agent and one of the commonest cytotoxic drugs leading to pulmonary parenchymal damage. It generally leads to interstitial pneumonitis and fibrosis, hypersensitivity reactions and acute respiratory distress syndrome. We describe an 8-year-old boy who, following prolonged bleomycin therapy, demonstrated extensive air dissection and extrapulmonary air, an unusual and fatal complication.
authors.affiliation: Department of Radiology, All India Institute of Medical Sciences, New Delhi, 110029, India. drtjain@yahoo.com
authors.forename: Tarun P
authors.initials: TP
authors.lastname: Jain
authors.forename: Sanjay
authors.initials: S
authors.lastname: Thulkar
authors.forename: Sanchita
authors.initials: S
authors.lastname: Saha
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.forename: Joseph
authors.initials: J
authors.lastname: Dominic
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D002648:Child; D004342:Drug Hypersensitivity / Q000209:etiology; D004417:Dyspnea / Q000139:chemically induced; D004646:Emphysema / Q000139:chemically induced; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D008297:Male; D008478:Mediastinal Emphysema / Q000139:chemically induced*; D011030:Pneumothorax / Q000139:chemically induced*
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin