The role of Abeta peptides in Alzheimer's disease.
The Abeta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving Abeta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of Abeta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.
Tickler
Anna K
AK
School of Chemistry, University of Melbourne, VIC 3010, Australia.
Wade
John D
JD
Separovic
Frances
F
D000544:Alzheimer Disease / Q000378:metabolism* / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism* / Q000633:toxicity / Q000648:ultrastructure; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D020836:Protein Structure, Quaternary
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor