title: [Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro].
abstract: OBJECTIVE
  To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro.
  
  
  METHODS
  Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro.
  
  
  RESULTS
  Seven xanthones, 1,7-dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models.
  
  
  CONCLUSIONS
  Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time.
authors.affiliation: Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100094, China.
authors.forename: Li-Lin
authors.initials: LL
authors.lastname: Lin
authors.forename: Feng
authors.initials: F
authors.lastname: Huang
authors.forename: Si-Bao
authors.initials: SB
authors.lastname: Chen
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Yang
authors.forename: Shi-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.forename: Pei-Gen
authors.initials: PG
authors.lastname: Xiao
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008264:Macrophages / Q000502:physiology; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D016897:Respiratory Burst / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C511009:1-methoxy-2,3-methylenedioxyxanthone; D000975:Antioxidants; D044004:Xanthones