title: International Equine Gene Mapping Workshop Report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources.
abstract: A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7%) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are < or = 5 cM and only 3% > or = 20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.
authors.affiliation: School of Veterinary Medicine, University of California, Davis, CA, USA. mctorrespenedo@ucdavis.edu
authors.forename: M C T
authors.initials: MC
authors.lastname: Penedo
authors.forename: L V
authors.initials: LV
authors.lastname: Millon
authors.forename: D
authors.initials: D
authors.lastname: Bernoco
authors.forename: E
authors.initials: E
authors.lastname: Bailey
authors.forename: M
authors.initials: M
authors.lastname: Binns
authors.forename: G
authors.initials: G
authors.lastname: Cholewinski
authors.forename: N
authors.initials: N
authors.lastname: Ellis
authors.forename: J
authors.initials: J
authors.lastname: Flynn
authors.forename: B
authors.initials: B
authors.lastname: Gralak
authors.forename: A
authors.initials: A
authors.lastname: Guthrie
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: G
authors.initials: G
authors.lastname: Lindgren
authors.forename: L A
authors.initials: LA
authors.lastname: Lyons
authors.forename: K H
authors.initials: KH
authors.lastname: Røed
authors.forename: J E
authors.initials: JE
authors.lastname: Swinburne
authors.forename: T
authors.initials: T
authors.lastname: Tozaki
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D005819:Genetic Markers; D006736:Horses / Q000235:genetics*; D016013:Likelihood Functions; D014960:X Chromosome
chemical_list: D005819:Genetic Markers