title: Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists.
abstract: Several potent and efficacious MCHr1 antagonists containing an ortho-amino benzamide or nicotinamide chemotype have been identified, exemplified by 28 and 50.
authors.affiliation: Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. Anil.Vasudevan@abbott.com
authors.forename: Anil
authors.initials: A
authors.lastname: Vasudevan
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: LaMarche
authors.forename: Christopher
authors.initials: C
authors.lastname: Blackburn
authors.forename: Jennifer Lee
authors.initials: JL
authors.lastname: Che
authors.forename: Courtney A
authors.initials: CA
authors.lastname: Luchaco-Cullis
authors.forename: Sujen
authors.initials: S
authors.lastname: Lai
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Marsilje
authors.forename: Michael A
authors.initials: MA
authors.lastname: Patane
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Souers
authors.forename: Derek
authors.initials: D
authors.lastname: Wodka
authors.forename: Bradley
authors.initials: B
authors.lastname: Geddes
authors.forename: Sumiao
authors.initials: S
authors.lastname: Chen
authors.forename: Seven
authors.initials: S
authors.lastname: Brodjian
authors.forename: Doug H
authors.initials: DH
authors.lastname: Falls
authors.forename: Brian D
authors.initials: BD
authors.lastname: Dayton
authors.forename: Eugene
authors.initials: E
authors.lastname: Bush
authors.forename: Michael
authors.initials: M
authors.lastname: Brune
authors.forename: Robin D
authors.initials: RD
authors.lastname: Shapiro
authors.forename: Kennan C
authors.initials: KC
authors.lastname: Marsh
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Hernandez
authors.forename: Hing L
authors.initials: HL
authors.lastname: Sham
authors.forename: Christine A
authors.initials: CA
authors.lastname: Collins
authors.forename: Philip R
authors.initials: PR
authors.lastname: Kym
mesh_terms: D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D051379:Mice; D008815:Mice, Inbred Strains; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D010599:Pharmacokinetics; D017481:Receptors, Somatostatin / Q000819:agonists / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D001549:Benzamides; C491209:Mchr1 protein, mouse; D017481:Receptors, Somatostatin; D062367:ortho-Aminobenzoates; D009536:Niacinamide