Fluid retention mediated by renal PPARgamma.
Thiazolidinediones are activators of the nuclear receptor PPARgamma with proven efficacy on glucose homeostasis. However, treatment with these drugs often results in fluid retention and edema. Recent studies establish a role for PPARgamma in renal sodium reabsorption, providing a mechanism for the plasma volume expansion induced by these drugs.
Staels
Bart
B
U545 INSERM Départment d'Athérosclérose Institut Pasteur de Lille and Faculté de pharmacie Université Lille II Lille, France.
D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D004487:Edema / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D047495:PPAR gamma / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology; D014883:Water-Electrolyte Imbalance
D047495:PPAR gamma; D045162:Thiazolidinediones