title: Regional cerebral blood flow in a patient with Nasu-Hakola disease.
abstract: We report a functional neuroimaging study of a 43-year-old woman with Nasu-Hakola disease (NHD). Regional cerebral blood flow (rCBF) images were measured with technetium-99m ethyl cysteinate dimer single photon emission computed tomography (SPECT). rCBF was decreased in the bilateral frontal lobes and thalamus. This finding was consistent with the known underlying neuropathology in patients with NHD. Brain SPECT is useful for demonstrating the pathophysiologic brain region in patients with NHD.
authors.affiliation: Department of Radiology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. tohru@med.teikyo-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Takeshita
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Kaminaga
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tatsumi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Furui
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D025063:Chromosome Disorders / Q000000981:diagnostic imaging; D003545:Cysteine / Q000031:analogs & derivatives; D015140:Dementia, Vascular / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000151:congenital / Q000000981:diagnostic imaging*; D008569:Memory Disorders / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010009:Osteochondrodysplasias / Q000151:congenital / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013577:Syndrome
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine