Interferon-gamma and cancer immunoediting.
Over the last 12 yr, we have shown that interferon-gamma and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial "cancer immunosurveillance" hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.
Dunn
Gavin P
GP
Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ikeda
Hiroaki
H
Bruce
Allen T
AT
Koebel
Catherine
C
Uppaluri
Ravi
R
Bui
Jack
J
Chan
Ruby
R
Diamond
Mark
M
White
J Michael
JM
Sheehan
Kathleen C F
KC
Schreiber
Robert D
RD
D000818:Animals; D016158:Genes, p53; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D007371:Interferon-gamma / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D015166:Monitoring, Immunologic; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D015398:Signal Transduction / Q000276:immunology; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency / Q000276:immunology
D016159:Tumor Suppressor Protein p53; D007371:Interferon-gamma