title: Cerebral autoregulation and ageing.
abstract: Little is known about the effects of ageing on cerebral autoregulation (CA). To examine the relationship between age and CA in adults, we conducted a prospective study using a non-invasive protocol without external stimuli. We studied 32 subjects, aged 23-68 years. They were assigned to a young group (28+/-5 years) and an old group (54+/-8 years). The groups were sex-matched. Transcranial Doppler ultrasonography (TCD) was used to record bilateral middle cerebral artery flow velocities (CBFV, cm/sec). Noninvasive beat-to-beat tonometric arterial blood pressure (ABP) measurement of the radial artery was used to record spontaneous blood pressure fluctuations. The Mx, an index of dynamic cerebral autoregulation (dCA), was calculated from a moving correlation between ABP and CBFV. We did not find a correlation between age and Mx. No statistically significant difference in the Mx between the groups (0.27+/-0.23, young, vs. 0.37+/-0.24, old) was demonstrated. Age does not affect dynamic cerebral autoregulation assessed by the Mx index in healthy adult subjects. This study supports findings from previous papers wherein CA was measured with protocols which require external stimuli. Further studies are needed to determine CA in subjects above 70 years of age.
authors.affiliation: Department of Neurosurgery, Westmead Hospital, Westmead, New South Wales, Australia.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Yam
authors.forename: Erhard W
authors.initials: EW
authors.lastname: Lang
authors.forename: Jim
authors.initials: J
authors.lastname: Lagopoulos
authors.forename: Kwok
authors.initials: K
authors.lastname: Yip
authors.forename: Jane
authors.initials: J
authors.lastname: Griffith
authors.forename: Yugan
authors.initials: Y
authors.lastname: Mudaliar
authors.forename: Nicholas W C
authors.initials: NW
authors.lastname: Dorsch
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000502:physiology; D017711:Nonlinear Dynamics; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods