GATA-1: one protein, many partners.
GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both DNA and protein partners. Disruption of either of these functions causes severe hematopoietic dysfunction and results in blood disorders, such as thrombocytopenia and anemia. Within this review, we will focus on the structural aspects of GATA-1 with regard to interactions with its many partners and the identification of several mutations that disrupt these interactions.
Lowry
Jason A
JA
School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia. j.lowry@mmb.usyd.edu.au
Mackay
Joel P
JP
D000740:Anemia / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004920:Erythropoiesis / Q000502:physiology*; D050982:GATA1 Transcription Factor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013921:Thrombocytopenia / Q000235:genetics / Q000378:metabolism; D034061:Thrombopoiesis / Q000502:physiology*
D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human