How the T cell receptor sees antigen--a structural view.
Structures of many of the cell surface receptor-ligand complexes mediating the interactions between T cells and target cells have been determined in the past ten years. While snapshots of T cell receptors bound to their peptide-MHC ligands appear to have defined a general interaction or "docking" solution, many of the most fundamental structural questions in antigen recognition lack detailed answers and thus pose exciting experimental challenges for the future.
Garcia
K Christopher
KC
Departments of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA. kcgarcia@stanford.edu
Adams
Erin J
EJ
D000818:Animals; D000941:Antigens / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D003429:Cross Reactions / Q000502:physiology; D006649:Histocompatibility Antigens / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008024:Ligands; D017434:Protein Structure, Tertiary; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism
D000941:Antigens; D006649:Histocompatibility Antigens; D008024:Ligands; D011948:Receptors, Antigen, T-Cell