title: Histopathological grading of laryngectomy specimens.
abstract: A material comprising 118 laryngectomy specimens, prepared by whole organ serial sectioning, was analyzed to determine the prognostic significance of histopathological tumor grading. No statistically significant association could be demonstrated between grading and a number of clinical and histopathological variables, including pathological staging, lymph node metastases or recurrence rate. The study supports the contention that the prognostic value of histopathological grading of laryngeal squamous cell carcinoma remains uncertain and unproven. Serial sections of the whole organ, processed by routine laboratory techniques, remain important for studying tumor extension but do not contribute to establishing histopathological grading as a significant prognostic parameter.
authors.affiliation: Department of Otolaryngology, Rikshospitalet, University of Oslo, Oslo, Norway. halvor.vermund@rikshospitalet.no
authors.forename: Halvor
authors.initials: H
authors.lastname: Vermund
authors.forename: Peter
authors.initials: P
authors.lastname: Krajci
authors.forename: Tor J
authors.initials: TJ
authors.lastname: Eide
authors.forename: Finn
authors.initials: F
authors.lastname: Winther
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D002454:Cell Differentiation; D006801:Humans; D007633:Keratins / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D008207:Lymphatic Metastasis; D011379:Prognosis; D012008:Recurrence
chemical_list: D007633:Keratins