[Association of genetic polymorphism of XRCC1 with susceptibility to acute childhood leukemia].
OBJECTIVE
To explore the association between genetic polymorphisms of XRCC1 and susceptibility to acute childhood leukemia.


METHODS
A case-control study with 63 childhood leukemia patients and 66 control subjects was conducted to investigate the role of three XRCC1 polymorphisms (c. 194, c. 280 and c. 399 ) on susceptibility to childhood leukemia. Genotyping was performed using Polymerase chain reaction-restrained fragment length polymorphism technique (PCR-RFLP) to detect the single nucleotide polymorphisms (SNPs) of XRCC1 gene.


RESULTS
There was a 2.235-fold increased risk of childhood leukemia for individuals carrying XRCC1c. 399 Gin allele (95% CI 1.038 - 4.812) compared with subjects carrying Arg/Arg allele, and the OR among boys was 3.110 (95% CI 1.235 - 7.831). No interaction was found between X-ray exposure and XRCC1 polymorphisms using Logistic regression analysis.


CONCLUSIONS
Polymorphism of XRCC1 gene may contribute to the higher risk of childhood leukemia.
Zhu
Ren
R
Department of Occupational Health, School of Public Health, Fudan University, Shanghai 200032, China.
Lu
Feng-Juan
FJ
Zhang
Zhong-Bin
ZB
Zhai
Xiao-Wen
XW
Liu
Jing
J
Lu
Guoliang
G
Wu
Yuxia
Y
Chen
Chao
C
Xia
Zhaolin
Z
D000208:Acute Disease; D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human