Building integrated approaches for the proteomics of complex, dynamic systems: NIH programs in technology and infrastructure development.
Proteomics technology and methods remain inadequate. Technological constraints contribute to an artificially static view of complex biological systems and a barrier between quantitative and interaction studies. Several NIH programs combine proteomics technology development with research on challenging biological problems to drive progress. A new initiative of the NIH Roadmap focuses on characterization of dynamic systems. The success of these programs will be judged by their impact on relevant biological problems.
Sheeley
Douglas M
DM
National Center for Research Resources, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 6701 Democracy Boulevard, MSC 4874, Bethesda, MD 20892, USA. sheeleyd@mail.nih.gov
Breen
Joseph J
JJ
Old
Susan E
SE
D035843:Biomedical Research; D006801:Humans; D009316:National Institutes of Health (U.S.); D040901:Proteomics / Q000295:instrumentation / Q000379:methods*; D013672:Technology; D014481:United States