title: Exploring an expedient IMDA reaction approach to construct the guanacastepene core.
abstract: Construction of the [5-7-6] tricyclic core of guanacastepenes was attempted by using the intramolecular Diels-Alder (IMDA) reaction and Me(3)Al-mediated ring opening of the oxabridge as key synthetic steps. The illustrated chemistry demonstrated a synthetic feasibility to build up the framework of guanacastepenes by the IMDA reaction. [reaction: see text]
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100871, China.
authors.forename: Chuang-Chuang
authors.initials: CC
authors.lastname: Li
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.forename: Xin-Hao
authors.initials: XH
authors.lastname: Zhang
authors.forename: Zhi-Xiang
authors.initials: ZX
authors.lastname: Xie
authors.forename: Jia-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Yun-Dong
authors.initials: YD
authors.lastname: Wu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D004224:Diterpenes; C409194:guanacastepene