title: A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.
abstract: Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee and the Mouse Genomic Nomenclature Committee, a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged.
authors.affiliation: Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry C1-74, Karolinska University Hospital at Huddinge, Stockholm, Sweden. mary.hunt@labmed.ki.se
authors.forename: Mary C
authors.initials: MC
authors.lastname: Hunt
authors.forename: Junji
authors.initials: J
authors.lastname: Yamada
authors.forename: Lois J
authors.initials: LJ
authors.lastname: Maltais
authors.forename: Mathew W
authors.initials: MW
authors.lastname: Wright
authors.forename: Ernesto J
authors.initials: EJ
authors.lastname: Podesta
authors.forename: Stefan E H
authors.initials: SE
authors.lastname: Alexson
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D051379:Mice; D005810:Multigene Family; D010170:Palmitoyl-CoA Hydrolase / Q000235:genetics; D051381:Rats; D009626:Terminology as Topic
chemical_list: D010170:Palmitoyl-CoA Hydrolase