title: [Effect of formaldehyde on energy metabolism in postnatal rat cortex neurons in culture].
abstract: OBJECTIVE
  The mechanism of the effect of formaldehyde on CNS which is much concerned to formaldehyde poisoning was studied.
  
  
  METHODS
  In the present study, incubation of postnatal rat cortex neurons in culture with formaldehyde at 1, 2, 4, 8 mg/L (medium) was carried out to evaluate the effect of formaldehyde on energy metabolism.
  
  
  RESULTS
  The result of cytochemistry showed a significant down-regulation of cytochrome oxidase activity after consecutive formaldehyde treatment for 4 hours compared with the control (P < 0.01), the significant dosage-response relationship was also observed (R value is - 0.92, P < 0.01).
  
  
  CONCLUSIONS
  The result demonstrates that excessive exposure of formaldehyde can decrease cytochrome oxidase activity in cortex neurons which indicates energy metabolism will be decreased and therefore normal physiology function would be damaged.
authors.affiliation: Department of Toxicology, Institute of Environment Health and Related Product Safety, China CDC, Beijing 100021, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Xue-Tao
authors.initials: XT
authors.lastname: Bai
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D005557:Formaldehyde / Q000633:toxicity*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005557:Formaldehyde; D003576:Electron Transport Complex IV