[Clinical study on spontaneous improvement after blood flow reconstruction interfered by tongxinluo capsule in patients with early stage acute myocardial infarction].
OBJECTIVE
To observe and evaluate the effect of tongxinluo capsule (TXL) on recovery of ventricular wall with segmental dyskinesia in patients with early stage acute myocardial infarction (AMI).


METHODS
One hundred and twelve AMI patients after percutaneous coronary intervention (PCI) or fibrinolytic therapy, were randomly divided into 2 groups, the control group (CG) treated with conventional medicine and the interfered group (IG) treated with conventional medicine plus TXL. The changes of ventricular wall motion, left ventricular end diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF) were observed at different time points (1-w, 2-w, 1-m, 3-m and 6-m) after PCI by using two dimensional echocardiography (2DE).


RESULTS
The ventricular dyskinetic segment recovery rate at 1-w, 2-w, 1-m and 6-m in IG was 11.9%, 18.1%, 18.8% and 70.02% respectively, which was significantly higher than the respective rates in CG (4.1%, 8.3%, 11.1% and 51.68%, P < 0.01), but the 3-m recovery rate in the two groups was insignificantly different. LVEDV increase rate in the two groups at 1-w was insignificantly different, but it significantly increased at 2-w and 1-m, and showed a higher rate in CG (P < 0.05). However, at 3-m and 6-m, it significantly decreased in IG but was insignificantly changed in CG. Improvement of LVEF was insignificant at 1-w, 2-w and 1-m in both groups, but at 3-m and 6-m, LVEF was significantly improved in the interfered group (P < 0.01), but still showed no obvious change in the control group.


CONCLUSIONS
Conventional western medicine combined with TXL can significantly decrease the infarction area, improve left ventricular diastolic function in patients with AMI.
You
Shi-jie
SJ
Treatment Center of Coronary Heart Diseases, Fuwai Hospital, China Academy of Medical Sciences, Beijing. youshijie6001@yahoo.com.cn
Chen
Ke-ji
KJ
Yang
Yue-jin
YJ
Gao
Runlin
R
Wu
Yongjian
Y
Zhang
Jian
J
Wang
Yanwu
Y
Chen
Jilin
J
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D009204:Myocardial Revascularization; D008517:Phytotherapy; D016277:Ventricular Function, Left
D002214:Capsules; D004365:Drugs, Chinese Herbal