title: Safety of low dose glucocorticoid treatment in rheumatoid arthritis: published evidence and prospective trial data.
abstract: Adverse effects of glucocorticoids have been abundantly reported. Published reports on low dose glucocorticoid treatment show that few of the commonly held beliefs about their incidence, prevalence, and impact are supported by clear scientific evidence. Safety data from recent randomised controlled clinical trials of low dose glucocorticoid treatment in RA suggest that adverse effects associated with this drug are modest, and often not statistically different from those of placebo.
authors.affiliation: Reumatologia, Hospitais da Universidade, 3000-075 Coimbra, Portugal. jdasilva@ci.uc.pt
authors.forename: J A P
authors.initials: JA
authors.lastname: Da Silva
authors.forename: J W G
authors.initials: JW
authors.lastname: Jacobs
authors.forename: J R
authors.initials: JR
authors.lastname: Kirwan
authors.forename: M
authors.initials: M
authors.lastname: Boers
authors.forename: K G
authors.initials: KG
authors.lastname: Saag
authors.forename: L B S
authors.initials: LB
authors.lastname: Inês
authors.forename: E J P
authors.initials: EJ
authors.lastname: de Koning
authors.forename: F
authors.initials: F
authors.lastname: Buttgereit
authors.forename: M
authors.initials: M
authors.lastname: Cutolo
authors.forename: H
authors.initials: H
authors.lastname: Capell
authors.forename: R
authors.initials: R
authors.lastname: Rau
authors.forename: J W J
authors.initials: JW
authors.lastname: Bijlsma
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002318:Cardiovascular Diseases / Q000139:chemically induced; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D009140:Musculoskeletal Diseases / Q000139:chemically induced; D016032:Randomized Controlled Trials as Topic
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids