Cleavage of oximes using a solid supported hypervalent organoiodine reagent.
A facile and efficient oxidative cleavage of oximes to form carbonyl compounds is reported using phenyl iodonium (III) diacetate (PIDA) and polymer supported polydiacetoxyiodostyrene. Regeneration of carbonyl compounds from corresponding oximes is an important reaction, since oxime derivatives constitute one of the primary methods for purification and characterization of carbonyl compounds. This process overcomes many of the disadvantages associated with other oxidative methods such as long reaction times, difficulties in isolation of products and formation of over oxidized products.
Kumar
Atul
A
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow- 226001, India. atulcdri@yahoo.com
Ahmad
Pervez
P
Akanksha
Murya
Ram Awatar
RA
D000085:Acetates / Q000737:chemistry; D007202:Indicators and Reagents; D007455:Iodine / Q000737:chemistry*; D008956:Models, Chemical; D009930:Organic Chemicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D010091:Oximes / Q000378:metabolism*; D011137:Polystyrenes / Q000737:chemistry
D000085:Acetates; D007202:Indicators and Reagents; D009930:Organic Chemicals; D010091:Oximes; D011137:Polystyrenes; D007455:Iodine