title: Effects of an impedance threshold valve upon hemodynamics in Standard CPR: studies in a refined computational model.
abstract: An impedance threshold valve (ITV) is a new airway adjunct for resuscitation that permits generation of a small vacuum in the chest during the recoil phase of chest compression.
  
  
  OBJECTIVE
  To explore in detail the expected magnitude and the hemodynamic mechanisms of circulatory augmentation by an ITV in Standard CPR.
  
  
  METHODS
  A 14-compartment mathematical model of the human cardiopulmonary system--upgraded to include applied chest compression force, elastic recoil of the chest wall, anatomic details of the heart and lungs, and the biomechanics of mediastinal compression--is exercised to explore the conditions required for circulatory augmentation by an ITV during various modes of CPR.
  
  
  RESULTS
  The ITV augments systemic perfusion pressure by about 5 mmHg compared to any particular baseline perfusion pressure without the ITV. When baseline perfusion is low, owing to either diminished chest compression force, the existence of a thoracic pump mechanism of blood flow, or the presence of an effective compression threshold, then the relative improvement produced by an ITV is significant. With an ITV the heart expands into soft pericardiac tissue, which makes the heart easier to compress.
  
  
  CONCLUSIONS
  An ITV can augment perfusion during CPR. The observed effectiveness of ITVs in the laboratory and in the clinic suggests a thoracic pump mechanism for Standard CPR, and perhaps also an effective compression threshold that must be exceeded to generate blood flow by external chest compression.
authors.affiliation: Department of Basic Medical Sciences, Purdue University, 1246 Lynn Hall, West Lafayette, IN 47907-1246, USA. babbs@purdue.edu
authors.forename: Charles F
authors.initials: CF
authors.lastname: Babbs
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000295:instrumentation*; D004867:Equipment Design; D006321:Heart / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D012016:Reference Values; D014618:Vacuum