title: Boolean control of aptamer binding states.
abstract: Molecules that perform Boolean calculations can analyze a series of inputs and make a decision to produce or not to produce an output, based on the presence or absence of inputs and a particular formula they encode. We now report that molecular computation performed by deoxyribozyme-based logic gates can be used to control the functional state of aptamers, switching them on or off based on the outcome of such computation.
authors.affiliation: Division of Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630W 168th Street, New York, New York 10032, USA.
authors.forename: Dmitry M
authors.initials: DM
authors.lastname: Kolpashchikov
authors.forename: Milan N
authors.initials: MN
authors.lastname: Stojanovic
mesh_terms: D039301:Computers, Molecular; D021881:DNA, Catalytic / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D021881:DNA, Catalytic; D009841:Oligonucleotides