title: [Effect of mexicor on oxidative stress in acute myocardial infarction].
abstract: Mexicor (5% solution and capsules) was used in 40 of 80 conventionally treated patients with acute myocardial infarction. The drug was given intravenously for 5 days, than intramuscularly (6-9 mg/kg) for 9 days and orally (0.1 mg t.i.d.) thereafter until discharge. Severity of oxidative stress was evaluated by K coefficient. Calculation of this coefficient required data on degree of oxidation of lipids in blood serum, serum levels of diene conjugates, malonic dialdehyde, alpha-tocopherol and ceruloplasmin. These parameters as well as activity of superoxide dismutase, glutathione peroxidase and catalase in erythrocytes were measured at admission, on days 2, 3, 7, 14 and at discharge. Mexicor treated compared with untreated (n=40) patients were characterized by diminished severity of oxidative stress at the account of lower levels of lipid peroxidation products and augmented compensatory potential of the endogenous antioxidant system.
authors.forename: A P
authors.initials: AP
authors.lastname: Golikov
authors.forename: B V
authors.initials: BV
authors.lastname: Davydov
authors.forename: D V
authors.initials: DV
authors.lastname: Rudnev
authors.forename: E V
authors.initials: EV
authors.lastname: Klychnikova
authors.forename: N S
authors.initials: NS
authors.lastname: Bykova
authors.forename: V A
authors.initials: VA
authors.lastname: Riabinin
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Polumiskov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Nikolaeva
authors.forename: P P
authors.initials: PP
authors.lastname: Golikov
mesh_terms: D000284:Administration, Oral; D002374:Catalase / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects*; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
chemical_list: D010847:Picolines; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C009820:6-methyl-2-ethyl-3-hydroxypyridine