Role of the central interleukin-1 in stress responses.
The molecules of interleukin-1 (IL-1) system are widely distributed in central nervous system. As a classical pro-inflammatory factor, central IL-1 has diverse biological functions and plays a pivotal role in a number of important physiological and pathophysiological processes. During the past few years, particular attentions have been directed to the stress mediator actions of central IL-1. This paper reviews some recent findings in the studies of central IL-1 functions in stress responses, including the effects of stress on central IL-1, the roles of IL-1 in the initiation of stress responses, the neural circuitries and intracellular signal transduction pathways involved in the central IL-1 mediated stress responses, as well as the actions of central IL-1 on brain high function and behavior under stressful conditions.
Zheng
Rui-Mao
RM
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100083, China;Laboratory for Higher Brain Functions, State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China;E-mail: sgzhu@bjmu.edu.cn.
Zhu
Shi-Gong
SG