Searching for obesity genes: progress and prospects.
Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Remarkable progress has been made in the molecular elucidation of monogenic forms of obesity both in rodents and in humans. The most common form of obesity, however, is considered to be a polygenic disorder arising from the interaction of multiple genetic and environmental factors. Identification and characterization of susceptibility genes underlying obesity will contribute to a greater understanding of the pathogenesis of obesity and ultimately will assist in the development of better strategies for prevention and therapeutic intervention. In this article, we discuss the current status and future perspectives for the genetic dissection of obesity, with a focus on the most striking or representative findings.
Liu
Yong-Jun
YJ
Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska 68131, USA. deng@creighton.edu
Xiao
Peng
P
Xiong
Dong Hai
DH
Recker
Robert R
RR
Deng
Hong-Wen
HW
D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015316:Genetic Therapy; D006801:Humans; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000628:therapy; D047495:PPAR gamma / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D054411:Receptors, Leptin
D047495:PPAR gamma; D022702:Receptors, Adrenergic, beta-3; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin