Aspects influencing genotyping method selection.
The variety of genotyping methods currently available and the evolution of their capabilities have facilitated an expansion of the field of pharmacogenomics. Traditionally, limited genotyping capabilities have restricted the generation and application of genotyping data for pharmacogenomic studies. With the variety of platforms and chemistries available for flexible, high-throughput genotyping, it is important to keep in mind the limitations imposed by both the polymorphisms that are to be interrogated and the type of pharmacogenomics study for which the data are being generated. This chapter is an overview of the constraints these factors impose on different genotyping methods and describes aspects important to the integration of genotyping into a pharmacogenomics study.
Imle
Peter
P
Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN, USA.
D000483:Alleles; D005821:Genetic Techniques; D005838:Genotype; D006801:Humans; D013058:Mass Spectrometry; D009154:Mutation; D036103:Nanotechnology; D010597:Pharmacogenetics / Q000379:methods; D010641:Phenotype; D016133:Polymerase Chain Reaction / Q000379:methods