title: HPLC-DAD for analysis of different classes of drugs in plasma.
abstract: A solid-phase extraction technique and HPLC-DAD method for drug screening in plasma were developed. This analytical method extracts and tests a number of drugs of different classes. The method includes; an acidic and basic Solid Phase Extraction (SPE) of plasma with C18 cartridges, a gradient elution of a modified cyano column with acidic buffer/acetonitrile eluent and a photodiode array ultraviolet (UV) detection. The drug screening procedure applied uses retention index and UV spectral data for the identification of compounds, may be appropriate in particular laboratory settings.
authors.affiliation: Department of Chemical Analysis, Forensic Science Laboratory, Amman, Jordan. mah13669@hotmail.com
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Alabdalla
mesh_terms: D000097:Acetonitriles; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D009294:Narcotics / Q000097:blood; D004364:Pharmaceutical Preparations / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D000097:Acetonitriles; D009294:Narcotics; D004364:Pharmaceutical Preparations; C032159:acetonitrile