Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities.
Nineteen compounds of various classes, such as flavonoid glycosides, pterocarpanoids, lipids, glycolipids, and alkaloids, were isolated and identified from the Desmodium gangeticum whole plant. Aminoglucosyl glycerolipid (8) is reported here for the first time. Its structure has been elucidated by spectroscopic and degradation studies. This novel compound exhibited in vitro antileishmanial and immunomodulatory activities, as it enhanced nitric oxide (NO) production and provided resistance against infection established in peritoneal macrophages by the protozoan parasite Leishmania donovani. Another known compound, glycosphingolipid (cerebroside) (7) was found to possess significant in vitro antileishmanial and immunomodulatory activities against the same parasite. Other compounds were found to be inactive.
Mishra
Pushpesh Kumar
PK
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, India.
Singh
Nasib
N
Ahmad
Ghufran
G
Dube
Anuradha
A
Maurya
Rakesh
R
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006224:Cricetinae; D007887:Fabaceae / Q000737:chemistry*; D006017:Glycolipids / Q000302:isolation & purification* / Q000494:pharmacology; D007155:Immunologic Factors / Q000302:isolation & purification* / Q000494:pharmacology; D007893:Leishmania donovani / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology
D000981:Antiprotozoal Agents; D006017:Glycolipids; D007155:Immunologic Factors