title: Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands.
abstract: A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.
authors.affiliation: College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA.
authors.forename: Guangrong
authors.initials: G
authors.lastname: Zheng
authors.forename: Linda P
authors.initials: LP
authors.lastname: Dwoskin
authors.forename: Agripina G
authors.initials: AG
authors.lastname: Deaciuc
authors.forename: Peter A
authors.initials: PA
authors.lastname: Crooks
mesh_terms: D000818:Animals; D008024:Ligands; D011485:Protein Binding; D051381:Rats; D011978:Receptors, Nicotinic / Q000378:metabolism; D013329:Structure-Activity Relationship; D014326:Tropanes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D008024:Ligands; D011978:Receptors, Nicotinic; D014326:Tropanes