title: [Gastroesophageal reflux in asthmatic children: prevalence and pathogenic role].
abstract: The relationship of gastroesophageal reflux disease and asthma is controversial. This study was performed to assess the prevalence of pathologic gastroesophageal reflux and its effect on pulmonary function tests in asthmatic children. The following study protocol was performed in a group of asthmatic children (n = 34, 22 male, age range: 2, 5-17 years): diagnosis of pathologic gastroesophageal reflux by means of 24h esophageal pH-monitoring; diagnosis of reflux esophagitis by means of upper digestive endoscopy and pulmonary function tests by means of spirometry. The results show a high prevalence (87%) of pathologic gastroesophageal reflux in asthmatic children. Additionally, there is an inverse correlation (r = -0.67) between the severity of pathologic gastroesophageal reflux and FEV1/FVC. In conclusion, there is a high prevalence of pathologic gastro-esophageal reflux in asthmatic children, contributing to asthma severity.
authors.affiliation: Clinica Pediatrie III- UMF "Iuliu Haţieganu", Cluj-Napoca, România.
authors.forename: Dorin
authors.initials: D
authors.lastname: Farcău
authors.forename: Daniela
authors.initials: D
authors.lastname: Dreghiciu
authors.forename: Paraschiva
authors.initials: P
authors.lastname: Cherecheş-Panţa
authors.forename: Mirela
authors.initials: M
authors.lastname: Popa
authors.forename: Mihaela
authors.initials: M
authors.lastname: Farcău
authors.forename: Mircea
authors.initials: M
authors.lastname: Nanulescu
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D004945:Esophagoscopy; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D005773:Gastroscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008991:Monitoring, Physiologic; D015995:Prevalence; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D012720:Severity of Illness Index; D013147:Spirometry