title: [Pathobiochemical aspects of surgical strategy in treatment of fractures of the tubular bones in combined traumas].
abstract: The article is devoted to pathobiochemical substantiation of the surgical strategy in treatment of fractures of the tubular bones in combined traumas. It was found that fractures of the tubular bones are a source of endogenous intoxication. Osteosynthesis facilitates the elimination of its manifestations. Stable osteosynthesis shortening the period of posttraumatic stress is a powerful adaptogenic factor. Optimization of the process of adaptation influenced by osteosynthesis is a result of blocked stream of pathological afferentation after fixation of the fragments. The performing of osteosynthesis facilitates quicker normalization of biochemical indices and transition of the casualty's organism to the phase of long-term adaptation. It explains the urge to early eliminate the dangerous for life conditions, to liquidate the sources of endotoxicosis and excessive afferent effects of the pathological foci which can often be caused by fractures of the tubular bones.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Suprun
authors.forename: B A
authors.initials: BA
authors.lastname: Plakhotnikov
mesh_terms: D005264:Femoral Fractures / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007103:Immobilization / Q000379:methods; D007610:Kallikreins / Q000097:blood; D019637:Orthopedic Procedures / Q000379:methods*; D013978:Tibial Fractures / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery
chemical_list: D007610:Kallikreins