Acanthosis nigricans as an adverse effect of highly active antiretroviral therapy in an adolescent girl with human immunodeficiency virus infection.
We report an 11-year-old girl with acanthosis nigricans that appeared after 4 years of treatment with didanosine, stavudine and amprenavir. Laboratory studies showed hyperglycemia, hyperinsulinemia and hypertriglyceridemia. Withdrawal of amprenavir resulted in disappearance of acanthosis nigricans and improvement of metabolic abnormalities.
Mur
Antonio
A
Service of Pediatrics, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
Seidel
Veronica
V
López-Vílchez
María Angeles
MA
Bonet
Mariona
M
Gilaberte
Montserrat
M
D000052:Acanthosis Nigricans / Q000139:chemically induced*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002648:Child; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans