Seven new meroditerpenoids, from the marine sponge Strongylophora strongylata, that inhibited the maturation of starfish oocytes.
Seven new meroditerpenoids, strongylophorines 13-19 (1-7), have been isolated together with the four known strongylophorines 2 (8), 3 (9), 4 (10), and 8 (11) by a screening method using oocytes of the starfish Asterina pectinifera from a marine sponge Strongylophora strongylata collected at Iriomote Island, Okinawa, Japan. The structures were assigned according to their spectral data. Ten strongylophorines inhibited the maturation of starfish oocytes in the range 1.1-37.6 microM (IC50), while strongylophorine 4 (10) was not active at 250 microM.
Liu
Hongwei
H
Department of Ocean Sciences, Tokyo University of Fisheries, Konan, Minato-ku, Tokyo, 108-8477, Japan.
Namikoshi
Michio
M
Akano
Kyoko
K
Kobayashi
Hisayoshi
H
Nagai
Hiroshi
H
Yao
Xinsheng
X
D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development*; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis; D013215:Starfish / Q000196:embryology
D004224:Diterpenes