title: Development of lupus nephritis in a patient with human T-cell lymphotropic virus type I-associated myelopathy.
abstract: A 77-year-old Japanese man with a 14-year history of human T-cell lymphotropic virus type I-associated myelopathy developed pancytopenia, proteinuria, renal dysfunction, and hypocomplementemia. Antinuclear antibody and anti-double-stranded DNA antibody test results were positive, and circulating immune complexes were detected. A renal biopsy showed diffuse and global mesangiocapillary proliferation with extensive subendothelial deposits. Immunofluorescence microscopy showed strong granular staining for immunoglobulins and complements in the mesangium and along capillary walls. Electron microscopy showed numerous mesangial and subendothelial electron-dense deposits. From these findings, systemic lupus erythematosus and diffuse global lupus nephritis were diagnosed. This is a rare case of a patient developing lupus nephritis during the long-term course of human T-cell lymphotropic virus type I-associated myelopathy.
authors.affiliation: Third Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan. wakui@med.akita-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Wakui
authors.forename: Rie
authors.initials: R
authors.lastname: Masai
authors.forename: Shin
authors.initials: S
authors.lastname: Okuyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtani
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komatsuda
authors.forename: Itaru
authors.initials: I
authors.lastname: Toyoshima
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sawada
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000209:etiology* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000821:virology; D008181:Lupus Nephritis / Q000209:etiology* / Q000821:virology; D008297:Male; D018716:Molecular Mimicry; D015493:Paraparesis, Tropical Spastic / Q000150:complications*