title: Economic evaluation of the administration of follitropin-beta with a pen device.
abstract: Previous studies suggest that administration of follitropin-beta with a pen device (Puregon Pen(R)) is more convenient, less painful and 16-18% more efficient. The aim of this study was to perform an economic evaluation of the administration of follitropin-beta by this pen device against follitropin-alpha by multidose and highly purified (HP) HMG by conventional syringe in IVF treatment by comparing the process utilities and the costs for the Dutch setting. Conjoint analysis assessed the process utilities for the three administration modes on a scale from 0 to 1. A decision analytic model estimated the costs of an average IVF cycle from a societal perspective. Patients estimated the process utility at 0.96 for the pen, 0.53 for the multidose and 0.36 for the conventional syringe. Additional costs were estimated at 0 Euros and 194 Euros, comparing the pen with multidose or conventional methods respectively. Assuming a 16% efficiency gain of the pen, costs ranged from Euros-135 (savings) to 60 Euros (extra costs). In conclusion, patients perceive sufficient benefits to the pen device to choose it over other dosing methods. Dominance of the pen device over the multidose method was shown. Compared with the conventional administration method, the added value of the pen device was 2.7 (0.96/0.36) times higher.
authors.affiliation: Mapi Values Netherlands, De Molen 84, 3995 AX, Houten, The Netherlands. karin.bruynesteyn@mapivalues.com
authors.forename: K
authors.initials: K
authors.lastname: Bruynesteyn
authors.forename: G J
authors.initials: GJ
authors.lastname: Bonsel
authors.forename: D D M
authors.initials: DD
authors.lastname: Braat
authors.forename: B C J M
authors.initials: BC
authors.lastname: Fauser
authors.forename: P
authors.initials: P
authors.lastname: Devroey
authors.forename: M L L
authors.initials: ML
authors.lastname: van Genugten
mesh_terms: D000328:Adult; D001530:Belgium; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage / Q000627:therapeutic use; D037201:Follicle Stimulating Hormone, beta Subunit / Q000008:administration & dosage* / Q000191:economics; D006062:Gonadotropins / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D007279:Injections, Subcutaneous / Q000191:economics*; D009426:Netherlands; D010062:Ovulation Induction / Q000191:economics* / Q000379:methods; D017060:Patient Satisfaction; D011247:Pregnancy; D012646:Self Administration / Q000191:economics / Q000295:instrumentation* / Q000706:statistics & numerical data; D013594:Syringes
chemical_list: D043373:Follicle Stimulating Hormone, Human; D037201:Follicle Stimulating Hormone, beta Subunit; D006062:Gonadotropins