Genetic network during neural crest induction: from cell specification to cell survival.
The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.
Steventon
Ben
B
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Carmona-Fontaine
Carlos
C
Mayor
Roberto
R
D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D004627:Embryonic Induction; D018507:Gene Expression Regulation, Developmental; D008957:Models, Genetic; D009432:Neural Crest / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D014157:Transcription Factors