title: Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves.
abstract: The efficacy of tulathromycin in the treatment of bovine respiratory disease (BRD) due to Mycoplasma bovis was determined following experimental infection. Two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 microg/ml) were inoculated into 145 calves. Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures, and lung lesion scores were significantly lower for tulathromycin-treated calves (P < .01). Tulathromycin was highly effective in the treatment of BRD due to M. bovis in calves regardless of the minimum inhibitory concentration of the challenge strain (1 or >64 microg/ml).
authors.affiliation: Veterinary Medicine Research and Development, Pfizer Ltd, Sandwich, Kent, UK.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Godinho
authors.forename: Al
authors.initials: A
authors.lastname: Rae
authors.forename: G David
authors.initials: GD
authors.lastname: Windsor
authors.forename: Nicola
authors.initials: N
authors.lastname: Tilt
authors.forename: Tim G
authors.initials: TG
authors.lastname: Rowan
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Sunderland
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001831:Body Temperature; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D003612:Dairying; D004187:Disaccharides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D008826:Microbial Sensitivity Tests; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000662:veterinary*; D045682:Mycoplasma bovis / Q000145:classification / Q000187:drug effects; D012720:Severity of Illness Index; D016896:Treatment Outcome; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides