title: Sex differentiated responses to intranasal trigeminal stimuli.
abstract: The aim of the study was to address sex-related hemispheric differences in trigeminal event-related potentials while controlling for the subjects' olfactory sensitivity. Event-related potentials to lateralized stimulation using the trigeminal stimulant CO(2) were recorded in 28 healthy young subjects (16 women). There was no sex-related difference in olfactory sensitivity. Results indicated a sex-differentiated response to trigeminally induced pain. Women were found to have generally higher amplitudes and shorter latencies of the late positive component than men. Moreover, men and women exhibited different hemispheric activations in that women expressed shorter latencies over the left hemisphere than men. The pronounced sex-related difference of the late positive component suggests a cognitive/emotional impact on the processing of intranasal pain as indicated by others.
authors.affiliation: Department of Psychology, Uppsala University, Sweden. Johan.Lundstrom@psyk.uu.se
authors.forename: Johan N
authors.initials: JN
authors.lastname: Lundström
authors.forename: Johannes
authors.initials: J
authors.lastname: Frasnelli
authors.forename: Maria
authors.initials: M
authors.lastname: Larsson
authors.forename: Thomas
authors.initials: T
authors.lastname: Hummel
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002245:Carbon Dioxide / Q000494:pharmacology*; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants; D009833:Olfactory Pathways / Q000187:drug effects* / Q000502:physiology; D010146:Pain / Q000209:etiology / Q000503:physiopathology; D010147:Pain Measurement / Q000379:methods; D011601:Psychophysics; D011930:Reaction Time / Q000502:physiology; D012727:Sex Characteristics; D013268:Stimulation, Chemical; D014276:Trigeminal Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D002245:Carbon Dioxide