title: Prognostic factors for alveolar regeneration: effect of space provision.
abstract: OBJECTIVE
  The role of space provision as an independent prognostic factor for periodontal regeneration remains to be established. The objective of this study was to evaluate the role of space provision on alveolar bone regeneration in periodontal sites.
  
  
  METHODS
  Critical size, supra-alveolar, periodontal defects were created in 11 young adult Beagle dogs. Six animals received a porous ePTFE device to provide for space provision. Five animals received sham surgery. The animals were euthanized at 8 weeks post-surgery. A histometric analysis assessed vertical regeneration of alveolar bone and the width of the alveolar crest at the base of the defect. Because of the correlation of within-dog measurements, a mixed model anova/ancova was used to analyse the data.
  
  
  RESULTS
  A significant relationship between the width of the alveolar crest at the base of the defect and bone regeneration was observed with no significant difference between sites receiving the different treatments (p=0.84). Bone regeneration at sites treated with the space-providing device was significantly greater compared with that at sites treated with sham surgery (p=0.0003), and the difference remained significant after adjusting for bone width (p=0.0001).
  
  
  CONCLUSIONS
  Space provision has a significant effect on alveolar bone regeneration in periodontal sites. The width of the alveolar bone appears to influence space provision effectively supporting bone regeneration.
authors.affiliation: Laboratory for Applied Periodontal and Craniofacial Regeneration, Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA. gpolimeni@hotmail.com
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Polimeni
authors.forename: Jasim M
authors.initials: JM
authors.lastname: Albandar
authors.forename: Ulf M E
authors.initials: UM
authors.lastname: Wikesjö
mesh_terms: D016301:Alveolar Bone Loss / Q000628:therapy*; D000539:Alveolar Process / Q000033:anatomy & histology; D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D008297:Male; D008336:Mandibular Diseases / Q000628:therapy; D010919:Placebos; D011138:Polytetrafluoroethylene / Q000627:therapeutic use; D011379:Prognosis; D015203:Reproducibility of Results; D013027:Space Maintenance, Orthodontic / Q000295:instrumentation* / Q000379:methods
chemical_list: D010919:Placebos; D011138:Polytetrafluoroethylene