Sclerosing cholangitis secondary to hepatic artery ligation after abdominal trauma.
Several causes have been postulated as responsible for secondary sclerosing cholangitis (SSC), mainly in adults, and, although in very different situations, ischaemia seems to be one of the most important factors. The term 'ischaemic cholangitis' has been used as a collective label for all these ischaemia-induced bile duct lesions. The biliary epithelium is dependent on arterial blood flow, unlike the hepatic parenchyma, which receives a dual blood supply from the hepatic artery and the portal vein. This makes the biliary epithelium very susceptible to changes in arterial blood flow. We present one adolescent patient who developed SSC after abdominal trauma with hepatectomy and ligation of the right hepatic artery. Different factors could have helped in the development of SSC in our patient (septicaemia, bile duct destruction, cholecystectomy) but right hepatic artery ligation seems to be the most important aetiological factor in the development of secondary ischaemic cholangitis.
Martín de Carpi
Javier
J
Department of Paediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu-Barcelona, Spain. javiermartin@hsjdbcn.org
Tarrado
Xavier
X
Varea
Vicente
V
D000063:Accidents, Traffic; D000293:Adolescent; D015209:Cholangitis, Sclerosing / Q000175:diagnosis / Q000209:etiology*; D006498:Hepatectomy / Q000009:adverse effects; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D008026:Ligation / Q000009:adverse effects; D008099:Liver / Q000293:injuries*; D008279:Magnetic Resonance Imaging; D008297:Male