The latest waves in calcium signaling.
Ca2+ is a universal second messenger that is a key component of myriad processes in all cell types. Perturbations in normal intracellular Ca2+ concentrations underlie many common pathological conditions, ranging from cardiac hypertrophy to ischemic death of neurons. A recent meeting addressed the contributions of Ca2+ and Ca2+ binding proteins to health and disease. Insights gleaned from mechanistic studies offered the potential for new therapeutic approaches to combat a variety of diseases resulting from alterations in Ca2+ homeostasis.
Montell
Craig
C
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. cmontell@jhmi.edu
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology; D019703:Calcineurin / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000502:physiology; D037282:Calreticulin / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D006331:Heart Diseases / Q000378:metabolism / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D014158:Transcription, Genetic
D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D019703:Calcineurin; D002118:Calcium