title: Kindling modifies morphine, cocaine and ethanol place preference.
abstract: Brailowsky and Garcia (1999) proposed the existence of a relationship between epilepsy and addiction. To prove this hypothesis, pentylenetetrazol kindled rats were tested in the conditioned place preference (CPP) paradigm for their reaction to various addictive drugs with different modes of action (morphine, cocaine and ethanol). In separate experiments, locomotor activity and body temperature after application of the same drugs were tested in kindled and non-kindled rats. In the CPP experiment there were significant differences between both groups of rats. Non-kindled animals showed place preference to morphine (5.0 mg/kg) or cocaine (20.0 mg/kg). This reaction was abolished in the kindled rats. Moreover, control rats demonstrated aversion to 2.0 g/kg ethanol. However, ethanol aversion was not detectable in kindled rats. Moreover, there was no difference between non-kindled and kindled rats in locomotor activity and body temperature after morphine (1.0 and 5.0 mg/kg), cocaine (10.0 and 20.0 mg/kg), or ethanol (0.5 and 2.0 g/kg) application. This suggests alterations in reward systems as a consequence of kindling. It is hypothesised that GABAergic neurones in the ventral tegmental area might play a major role in the alterations found.
authors.affiliation: Institute of Pharmacology and Toxicology, Otto-von-Guericke University, Faculty of Medicine, Leipziger Str. 44, 39120, Magdeburg, Germany. axel.becker@medizin.uni-magdeburg.de
authors.forename: Axel
authors.initials: A
authors.lastname: Becker
authors.forename: Marco
authors.initials: M
authors.lastname: Schmitz
authors.forename: Gisela
authors.initials: G
authors.lastname: Grecksch
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D003042:Cocaine / Q000008:administration & dosage*; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage*; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009294:Narcotics / Q000008:administration & dosage*; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000378:metabolism; D013997:Time Factors
chemical_list: D002492:Central Nervous System Depressants; D003292:Convulsants; D009294:Narcotics; D000431:Ethanol; D013395:Sucrose; D009020:Morphine; D003042:Cocaine; D010433:Pentylenetetrazole