A novel oxidative rearrangement of 6-methoxypyran-2-ones.
As part of our continuing studies of pyrone-containing natural products, a series 6-methoxypyran-2-ones were synthesized. These were found to react with molecular oxygen at 20 degrees C, and this novel reaction yielded a series of highly functionalized alpha,beta-butenolides. [reaction: see text]
Eade
Serena J
SJ
Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Adlington
Robert M
RM
Cowley
Andrew R
AR
Walter
Magnus W
MW
Baldwin
Jack E
JE