Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol.
This study was undertaken to examine the effects of subsequent administration of antipsychotic drugs (clozapine and haloperidol) on cognitive deficits in mice after repeated administration of phencyclidine (PCP). In the novel object recognition test, repeated administration of PCP (10 mg/kg) significantly decreased exploratory preference in the retention test session but not in the training test session. PCP-induced deficits were significantly improved by subsequent subchronic (2 weeks) administration of clozapine (5 mg/kg), but not haloperidol (0.1 mg/kg). These findings suggest that PCP-induced cognitive deficits using the novel object recognition test may be a potential animal model of atypical antipsychotic activity.
Hashimoto
Kenji
K
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp
Fujita
Yuko
Y
Shimizu
Eiji
E
Iyo
Masaomi
M
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003024:Clozapine / Q000494:pharmacology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000517:prevention & control*; D005106:Exploratory Behavior / Q000187:drug effects; D006213:Hallucinogens / Q000008:administration & dosage / Q000633:toxicity; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010622:Phencyclidine / Q000008:administration & dosage / Q000633:toxicity; D013997:Time Factors
D014150:Antipsychotic Agents; D006213:Hallucinogens; D010622:Phencyclidine; D003024:Clozapine; D006220:Haloperidol