title: A space-time cluster of adverse events associated with canine rabies vaccine.
abstract: Electronic medical records of a large veterinary practice were used for surveillance of potential space-time clustering of adverse events associated with rabies vaccination in dogs. The study population was 257,564 dogs vaccinated in 169 hospitals in 13 US metropolitan areas during a 24-month period. Using a scan statistic for population rate data, significant space-time clusters were identified involving the Atlanta and Tampa/St. Petersburg areas during a 4-month period. Separate spatial-temporal analyses of these cities using coordinates for individual address coordinates identified one significant patient cluster (P=0.002), associated with a 23.26 km-radius area in Atlanta (20 adverse events in 702 dogs; 2.85%) from November 2002 through February 2003. This percentage of adverse events was significantly increased after adjustment for host-related factors and the number of concurrent vaccinations.
authors.affiliation: Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USA. gemoore@purdue.edu
authors.forename: George E
authors.initials: GE
authors.lastname: Moore
authors.forename: Michael P
authors.initials: MP
authors.lastname: Ward
authors.forename: Martin
authors.initials: M
authors.lastname: Kulldorff
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caldanaro
authors.forename: Lynn F
authors.initials: LF
authors.lastname: Guptill
authors.forename: Hugh B
authors.initials: HB
authors.lastname: Lewis
authors.forename: Lawrence T
authors.initials: LT
authors.lastname: Glickman
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000818:Animals; D004283:Dog Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D004285:Dogs; D006762:Hospitals, Animal; D011159:Population Surveillance; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000009:adverse effects* / Q000276:immunology; D011820:Rabies virus / Q000276:immunology; D011996:Records / Q000662:veterinary; D013029:Space-Time Clustering; D014765:Viral Vaccines / Q000009:adverse effects* / Q000276:immunology
chemical_list: D011819:Rabies Vaccines; D014765:Viral Vaccines