title: Perspective: a program to improve protein biomarker discovery for cancer.
abstract: Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.
authors.affiliation: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North, PO Box 19024, Seattle, WA 98109-1024, USA.
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
authors.forename: Leigh
authors.initials: L
authors.lastname: Anderson
authors.forename: Richard
authors.initials: R
authors.lastname: Caprioli
authors.forename: Brian
authors.initials: B
authors.lastname: Druker
authors.forename: Leland
authors.initials: L
authors.lastname: Hartwell
authors.forename: Richard
authors.initials: R
authors.lastname: Smith
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D019295:Computational Biology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D025202:Molecular Diagnostic Techniques; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D011506:Proteins
chemical_list: D014408:Biomarkers, Tumor; D011506:Proteins