Reactivity of a new class of P450 enzyme models.
P450 enzyme models carrying a SO3(-) ligand coordinating to iron have been synthesized and characterized. These complexes show characteristics very similar to those of iron-heme cofactors of P450 enzymes. Their reactivity towards different reactions catalyzed by P450 enzymes such as epoxidation of double bonds, hydroxylation of non-activated C-H bonds, N-dealkylation of amines, and cleavage of diols (C-C-bond cleavage) has been investigated.
Meyer
Dominik
D
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
Leifels
Tycho
T
Sbaragli
Laura
L
Woggon
Wolf-D
WD
D003198:Computer Simulation; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D013056:Spectrophotometry, Ultraviolet; D013447:Sulfites / Q000378:metabolism
D008024:Ligands; D013447:Sulfites; D003577:Cytochrome P-450 Enzyme System