A SIRTain role in pancreatic beta cell function.
Genes formerly thought to be involved solely in the regulation of life span have increasingly become implicated in the regulation of metabolic processes. Moynihan et al.(2005[this issue of Cell Metabolism]) now demonstrate that increasing levels of Sirt1 in the pancreatic beta cells of mice result in a more efficient glucose handling due to enhanced glucose-stimulated insulin secretion.
Leibiger
Ingo B
IB
The Rolf Luft Center for Diabetes Research Department of Molecular Medicine and Surgery Karolinska Institutet SE-171 76 Stockholm Sweden.
Berggren
Per-Olof
PO
D000818:Animals; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007473:Ion Channels; D007515:Islets of Langerhans / Q000166:cytology / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000378:metabolism; D051379:Mice; D024101:Mitochondrial Proteins / Q000378:metabolism; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*; D000071246:Uncoupling Protein 2
D007328:Insulin; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D000071246:Uncoupling Protein 2; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D037761:Sirtuins; D005947:Glucose