title: Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients.
abstract: Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 microg/mL). The difference in survival was significant during TB treatment (log rank, p<0.02) and after long-term follow-up (log rank, p<0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per microg of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per microg of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients.
authors.affiliation: Department of Infectious Diseases, Copenhagen University Hospitals Hvidovre, Copenhagen, Denmark. tbygum@gmail.com
authors.forename: T B
authors.initials: TB
authors.lastname: Knudsen
authors.forename: P
authors.initials: P
authors.lastname: Gustafson
authors.forename: G
authors.initials: G
authors.lastname: Kronborg
authors.forename: T B
authors.initials: TB
authors.lastname: Kristiansen
authors.forename: S K
authors.initials: SK
authors.lastname: Moestrup
authors.forename: J O
authors.initials: JO
authors.lastname: Nielsen
authors.forename: V
authors.initials: V
authors.lastname: Gomes
authors.forename: P
authors.initials: P
authors.lastname: Aaby
authors.forename: I
authors.initials: I
authors.lastname: Lisse
authors.forename: H J
authors.initials: HJ
authors.lastname: Møller
authors.forename: J
authors.initials: J
authors.lastname: Eugen-Olsen
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D011956:Receptors, Cell Surface / Q000097:blood*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D011956:Receptors, Cell Surface; C027079:hemoglobin-haptoglobin receptor