Mantle cell lymphoma presenting with paraproteinemia.
Mantle cell lymphoma (MCL) is most frequently diagnosed by the routine histological (HP) and immunohistochemical (IH) examination. Herein we present a case of 47-yr-old female with general lymphadenopathy and leukemic blood picture. She was initially diagnosed with marginal zone lymphoma (MZL). This diagnosis was based not only on the HP/IH examination but also on the presence of IgM paraproteinemia. Flow cytometry (FCM) examination was helpful in making of the final diagnosis of MCL. Fluorescence in situ hybridization and cyclin D1 mRNA detection by RT-PCR additionally confirmed the MCL diagnosis. The IgM paraproteinemia is rare in MCL, although is a common feature of lymphoplasmacytoid lymphomas (LPL) and is considered a major characteristic of Waldenström's macroglobulinemia (WM).
Rymkiewicz
Grzegorz
G
Department of Pathology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland. gregorzrymkiewicz@coi.waw.pl
Gos
Monika
M
Błachnio
Katarzyna
K
Woroniecka
Renata
R
Swoboda
Paweł
P
Pieńkowska-Grela
Barbara
B
Kulińska
Marika
M
Borawska
Anna
A
Janik
Przemysław
P
Walewski
Jan
J
D004273:DNA, Neoplasm; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D020522:Lymphoma, Mantle-Cell / Q000150:complications* / Q000175:diagnosis*; D008875:Middle Aged; D010265:Paraproteinemias / Q000209:etiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D004273:DNA, Neoplasm; D007075:Immunoglobulin M