Pyrimidines as the cytostatic drugs.
Investigations on new cytostatic drugs have attracted a worldwide interest during the past few years. The pyrimidine derivatives possessing such the activity are amongst the biologically active compounds of a considerable pharmaceutical significance. All the research works on syntheses of these compounds are aimed at modifications in the cytosine ring or at changes in the dihydrofolic acid structure as well as at condensation of the pyrimidine ring system with other aromatic or heterocyclic rings.
Cieplik
J
J
Department of Organic Chemistry, School of Medicine, 9 Grodzka Str., 50-137 Wrocław, Poland.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003596:Cytosine / Q000737:chemistry; D015195:Drug Design; D005492:Folic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011743:Pyrimidines; C010920:dihydrofolate; D003596:Cytosine; D005492:Folic Acid