title: Impact of hypertensive disorders of pregnancy at term on infant birth weight.
abstract: This study was performed to investigate the impact of hypertensive disorders of pregnancy at term on neonatal birth weight. All singleton live births delivered between 37 and 42 weeks of gestation complicated by hypertensive disorders over a 7-year period (n = 362) was compared to 34 783 uncomplicated singleton deliveries in the same period. The individualized gestation-related optimal weight (GROW) was calculated for each individual case adjusted for the effects of maternal booking weight, height, parity, gestation at delivery, and fetal sex. Small-for-gestational-age (SGA) was defined as a birth weight less than the 10th percentile of the GROW. The incidence of SGA babies was significantly higher in subjects with preeclampsia and eclampsia than in control subjects (24.6 versus 11.3%; odds ratio = 2.55; 95% CI: 1.84, 3.55). Preeclampsia significantly reduced fetal birth weight by 130 g or 4.3%. Those with eclampsia on average had a neonatal birth weight 349 g or 11.0% below that of the GROW. In contrast, there was no significant difference in the incidence of SGA babies or degree of deviation from GROW between those with or without gestational hypertension.
authors.affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. tzekinlau@cuhk.edu.hk
authors.forename: Tze Kin
authors.initials: TK
authors.lastname: Lau
authors.forename: Man Wah
authors.initials: MW
authors.lastname: Pang
authors.forename: Daljit S
authors.initials: DS
authors.lastname: Sahota
authors.forename: Tse Ngong
authors.initials: TN
authors.lastname: Leung
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000502:physiology; D011247:Pregnancy; D012016:Reference Values