title: Disruption of cerebellar development: potential complication of extreme prematurity.
abstract: OBJECTIVE
  Infants with very low birth weight are at high risk for cerebral lesions. Although supratentorial brain damage is a common radiologic finding, posterior fossa pathologies are rare. We studied the morphology of cerebellar involvement in a large series of 28 premature infants born before the 30th week of gestation to define typical patterns and identify possible risk factors for this pathology.
  
  
  METHODS
  Cranial sonograms were obtained in the early neonatal period. MR imaging was performed between the 2nd month and the 6th year of life. Morphologic patterns of cerebellar involvement were evaluated.
  
  
  RESULTS
  Three morphologic patterns of cerebellar involvement were recognized: (1) symmetric volume reduction of the cerebellar hemispheres, which were floating immediately beneath the tentorium, and a small vermis with preserved shape; (2) symmetrical reduction in hemispheric volume with an enlarged, balloon-shaped fourth ventricle and a small, deformed vermis; and (3) normal overall cerebellar shape with extensive reduction of its dimensions. A small brain stem with flattened anterior curvature of the pons and loss of supratentorial white matter was present in all patients.
  
  
  CONCLUSIONS
  Symmetric cerebellar volume reduction was found as a consequence of extreme prematurity. Selective vulnerability of the developing cerebellum in the window of 24-30 weeks of gestation, combined with several additive perinatal risk factors (eg, hemosiderin deposits) seems to lead to destruction of immature structures and developmental arrest. Therefore, the resulting condition is the consequence of disrupted cerebellar development.
authors.affiliation: Department of Neonatology and Pediatric Intensive Care, University Children's Hospital, Vienna, Austria.
authors.forename: Agnes
authors.initials: A
authors.lastname: Messerschmidt
authors.forename: Peter C
authors.initials: PC
authors.lastname: Brugger
authors.forename: Eugen
authors.initials: E
authors.lastname: Boltshauser
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Zoder
authors.forename: Walter
authors.initials: W
authors.lastname: Sterniste
authors.forename: Robert
authors.initials: R
authors.lastname: Birnbacher
authors.forename: Daniela
authors.initials: D
authors.lastname: Prayer
mesh_terms: D002531:Cerebellum / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000473:pathology; D002657:Child Development; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D019102:Infant, Very Low Birth Weight; D008279:Magnetic Resonance Imaging; D014463:Ultrasonography