title: Apo E genotype not associated with intravascular coagulation in traumatic brain injury.
abstract: There is considerable evidence linking both genotype and coagulopathy to vascular complications of traumatic brain injury (TBI) and other cerebral insults. The authors explored a possible connection between the apolipoprotein E (Apo E) genotype, coagulopathy and intravascular microthombosis (IMT) in TBI. The predicted association was not confirmed.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania, 105B Hayden Hall/3320 Smith Walk, Philadelphia, PA 19104-6316, USA.
authors.forename: Sherman C
authors.initials: SC
authors.lastname: Stein
authors.forename: David I
authors.initials: DI
authors.lastname: Graham
authors.forename: Xiao-Han
authors.initials: XH
authors.lastname: Chen
authors.forename: Laurence
authors.initials: L
authors.lastname: Dunn
authors.forename: Douglas H
authors.initials: DH
authors.lastname: Smith
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications*; D002545:Brain Ischemia / Q000235:genetics* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000503:physiopathology*; D004252:DNA Mutational Analysis; D004211:Disseminated Intravascular Coagulation / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D020767:Intracranial Thrombosis / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics; D011517:Prothrombin Time
chemical_list: D001057:Apolipoproteins E; D020033:Protein Isoforms