Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study.
In 2002, population- and treatment center-based surveillance was used to study the disease burden of shigellosis in rural Hebei Province in the People's Republic of China. A total of 10,105 children with diarrhea or dysentery were enrolled. Infants were treated most frequently for diarrhea (1,388/1,000/year) followed by children < or = 5 years old (618/1,000/year). Shigellosis was treated most often in children 3-4 years old (32/1,000/year) and people > 60 years of age (7/1,000/year). Fifty-six percent (184 of 331) Shigella isolates were detected in patients who had non-bloody diarrhea. Shigella flexneri was identified in 93% of 306 isolates. The most common S. flexneri serotypes were 1a (34%), X (33%), and 2a (28%). More than 90% of the Shigella isolates were resistant to cotrimoxazole and nalidixic acid, but remained susceptible to ciprofloxacin, norfloxacin, and gentamicin. Widespread resistance to antibiotics adds urgency to the development and use of vaccines to control shigellosis.
Wang
Xuan-Yi
XY
International Vaccine Institute, Seoul, South Korea. xywang@ivi.int
Du
Lin
L
Von Seidlein
Lorenz
L
Xu
Zhi-Yi
ZY
Zhang
Ying-Lin
YL
Hao
Zhi-Yong
ZY
Han
Oak-Pil
OP
Ma
Jing-Chen
JC
Lee
Hye-Jon
HJ
Ali
Mohammad
M
Han
Chang-Quan
CQ
Xing
Zhan-Chun
ZC
Chen
Ji-Chao
JC
Clemens
John
J
D000293:Adolescent; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002681:China; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D004405:Dysentery, Bacillary / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011159:Population Surveillance; D012424:Rural Population; D012621:Seasons; D012760:Shigella / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D012763:Shigella flexneri / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents