title: A case study of radiotherapy planning for a bilateral metal hip prosthesis prostate cancer patient.
abstract: The purpose of this report is to communicate the observed advantage of intensity-modulated radiotherapy (IMRT) in a patient with bilateral metallic hip prostheses. In this patient with early-stage low-risk disease, a dose of 74 Gy was planned in two phases--an initial 50 Gy to the prostate and seminal vesicles and an additional 24 Gy to the prostate alone. Each coplanar beam avoided the prosthesis in the beam's eye view. Using the same target expansions for each phase, IMRT and 3D-conformal radiotherapy (CRT) plans were compared for target coverage and inhomogeneity as well as dose to the bladder and rectum. The results of the analysis demonstrated that IMRT provided superior target coverage with reduced dose to normal tissues for both individual phases of the treatment plan as well as for the composite treatment plan. The dose to the rectum was significantly reduced with the IMRT technique, with a composite V 80 of 35% for the IMRT plan versus 70% for 3D-CRT plan. Similarly, the dose to the bladder was significantly reduced with a V 80 of 9% versus 20%. Overall, various dosimetric parameters revealed the corresponding 3D-CRT plan would not have been acceptable. The results indicate significant success with IMRT in a clinical scenario where there were no curative alternatives for local treatment other than external beam radiotherapy. Therefore, definitive external beam radiation of prostate cancer patients with bilateral prosthesis is made feasible with IMRT. The work described herein may also have applicability to other groups of patients, such as those with gynecological or other pelvic malignancies.
authors.affiliation: Department of Radiation and Cellular Oncology, The University of Chicago Hospitals, Chicago, IL 60637, USA.
authors.forename: Andy
authors.initials: A
authors.lastname: Su
authors.forename: Chester
authors.initials: C
authors.lastname: Reft
authors.forename: Carla
authors.initials: C
authors.lastname: Rash
authors.forename: Jennifer
authors.initials: J
authors.lastname: Price
authors.forename: Ashesh B
authors.initials: AB
authors.lastname: Jani
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D000368:Aged; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008670:Metals; D011467:Prostate / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D012007:Rectum / Q000528:radiation effects; D001743:Urinary Bladder / Q000528:radiation effects
chemical_list: D008670:Metals