[Association of two exonic genetic polymorphisms in the DNA repair gene XPC with risk of lung cancer in Chinese population].
OBJECTIVE
To explore the relationship between two exonic polymorphisms of DNA repair gene XPC and the susceptibility to lung cancer.


METHODS
Genotypes were determined by the primer introduced restriction analysis-PCR(PIRA-PCR) and the PCR-restriction fragment length polymorphism(PCR-RFLP) approaches, respectively, in 320 histologically-confirmed lung cancer cases and 322 age and sex frequency-matched cancer-free controls.


RESULTS
Multivariate logistic regression analysis revealed that individuals carrying at least one 499Val variant allele (Ala/Val + Val/Val genotypes) had a significantly increased risk for lung cancer (adjusted OR=1.54; 95%CI: 1.11-2.14), compared with the wild-type genotype (499Ala/Ala). Furthermore, individuals with both putative risk genotypes had a significantly higher risk (adjusted OR=2.55; 95%CI: 1.45-4.52), compared with those with both wild-genotypes. In addition, a potential super multiplicative gene-environment interaction between Ala499Val genotypes and smoking on lung cancer risk was unveiled. The odds ratios of lung cancer for individuals with both putative risk genotypes were 2.63 (95%CI=1.23-5.62) in nonsmokers and 7.36 (95%CI=3.19-17.0) in smokers, respectively.


CONCLUSIONS
These findings support the hypothesis that these two XPC variants may contribute to the risk of developing lung cancer.
Hu
Zhi-bin
ZB
Department of Epidemiology & Biostatistics, School of Public Hbshen@njmu.edu.cn.
Wang
Yong-gang
YG
Ma
Hong-xia
HX
Tan
Wen
W
Niu
Ju-yin
JY
Lin
Dong-xin
DX
Shen
Hong-bing
HB
D044466:Asian People / Q000235:genetics; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D004268:DNA-Binding Proteins; C086984:XPC protein, human