[Correlation of polymeric immunoglobulin receptor gene polymorphisms to susceptibility of nasopharyngeal carcinoma].
OBJECTIVE
Polymeric immunoglobulin receptor (pIgR) gene plays a central role in immune response, and is closely related to Epstein-Barr virus (EBV) infection. Therefore, it is an ideal candidate gene for research on genetic susceptibility of nasopharyngeal carcinoma (NPC). This study was designed to explore correlation of pIgR gene polymorphisms to genetic susceptibility of NPC.


METHODS
Four single nucleotide polymorphisms (SNPs) within the exon regions of pIgR were detected by polymerase chain reaction (PCR); pIgR was genotyped in 528 NPC patients and 408 healthy individuals in the Cantonese population to analyze frequencies of its allelic genes.


RESULTS
Differences in frequencies of the 4 SNPs between NPC patients and healthy controls were not significant (P > 0.05). All subjects were categorized into 2 groups by age of 45ûof the subjects in age of < or =45 group, the frequency of minor allele T of SNP C8880T was significantly higher in NPC patients than in healthy controls (7% vs. 4%, P < 0.05). Individuals carried allele T suffered higher risk of NPC (odds ratio=1.84).


CONCLUSIONS
SNP C8880T of pIgR is related with NPC susceptibility; pIgR gene may be associated to risk of NPC development.
Fan
Qin
Q
Skate Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
Jia
Wei-Hua
WH
Zhang
Ru-Hua
RH
Yu
Xing-Juan
XJ
Chen
Li-Zhen
LZ
Feng
Qi-Sheng
QS
Zeng
Yi-Xin
YX
D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D019056:Receptors, Polymeric Immunoglobulin / Q000235:genetics*; D012307:Risk Factors
D019056:Receptors, Polymeric Immunoglobulin