Post-transplant multiple myeloma in a pediatric renal transplant patient.
Post-transplant lymphoproliferative disease (PTLD) is a well-recognized complication of the intense immunosuppression required in solid organ and bone marrow transplant recipients. The clinical presentation is varied and can range from a benign infectious mononucleosis-like syndrome to malignant lymphoma. PTLD manifesting as multiple myeloma occurs rarely. We report the unique occurrence of Epstein-Barr virus (EBV)-associated post-transplant multiple myeloma in a 16-year-old male. In contrast to previously described cases of PTLD-myeloma type, this patient was very young, had a clear association with EBV, and an indolent clinical course.
Tcheng
Wendy Y
WY
Gwynne Hazen Cherry Memorial Laboratories, Division of Pediatric Hematology-Oncology, UCLA, Los Angeles, California, USA. wtcheng@labiomed.org
Said
Jonathan
J
Hall
Theodore
T
Al-Akash
Samhar
S
Malogolowkin
Marcio
M
Feig
Stephen A
SA
D000293:Adolescent; D016027:Heart Transplantation / Q000009:adverse effects; D004854:Herpesvirus 4, Human; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009101:Multiple Myeloma / Q000209:etiology* / Q000473:pathology / Q000821:virology