title: Serum Ca 125 levels in children with acute leukemia and lymphoma.
abstract: Ca 125 is a tumor marker for the diagnosis and monitoring of ovarian carcinoma. We investigated serum Ca 125 levels in 44 children with leukemia and 59 children with lymphoma at initial presentation and 4 weeks after chemotherapy. Serum Ca 125 levels were measured chemilumimetrically with a sandwich enzyme-linked immunosorbent assay. The incidence of elevated serum Ca 125 levels was significantly higher in children with leukemia (14 children) and lymphoma (26 children) than in the healthy children (2 children). In the patients with non-Hodgkin's lymphoma (NHL) who had abdominal involvement and/or serous membrane involvement (ascides, pleural, pericardial effusion) at presentation, serum Ca 125 levels were significantly higher than in the patients without abdominal and/or serosal involvement. Serum Ca 125 levels were impressively increased in the patients with Burkitt's lymphoma (BL) in whom abdominal and/or serous membrane involvement were observed more frequently than the other types of lymphoma. The increased serum Ca 125 levels in the patients returned to normal 4 weeks after chemotherapy when they achieved complete remission. In conclusion, serum Ca 125 seems to be a good indicator for serous membrane involvement and it seems to be a promising tumor marker in the assessment of therapeutic response in children with leukemia and NHL.
authors.affiliation: Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Birgen
authors.forename: Ulya
authors.initials: U
authors.lastname: Ertem
authors.forename: Feride
authors.initials: F
authors.lastname: Duru
authors.forename: Gürses
authors.initials: G
authors.lastname: Sahin
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Yüksek
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Bozkurt
authors.forename: Can Demir
authors.initials: CD
authors.lastname: Karacan
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Aksoy
mesh_terms: D002051:Burkitt Lymphoma / Q000097:blood* / Q000628:therapy; D018394:CA-125 Antigen / Q000097:blood*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000628:therapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000628:therapy; D011237:Predictive Value of Tests; D012074:Remission Induction / Q000379:methods
chemical_list: D018394:CA-125 Antigen