Effect of vitamin E on memory retention in rats: possible involvement of cholinergic system.
This study concerned effects of vitamin E and the cholinergic system on memory retention of passive avoidance learning in rats. Post-training intracerebroventricular (i.c.v.) injections were carried out in all experiments. Administrations of vitamin E (10, 25 and 50 microg/rat), nicotine (0.1 microg/rat) and pilocarpine (0.5 microg/rat), the muscarinic receptor agonist increased memory retention, while mecamylamine (0.01, 0.1 and 0.5 microg/rat), the nicotinic receptor antagonist and scopolamine (0.1, 1 and 5 microg/rat), the muscarinic receptor antagonist decreased memory retention. The combination of vitamin E with nicotine or pilocarpine showed potentiation. Effects of mecamylamine or scopolamine were attenuated by vitamin E. It is concluded that vitamin E has a close interaction with cholinergic system in memory retention process.
Eidi
Akram
A
Department of Biology, Science and Research Institute, Islamic Azad University, Tehran, Iran. akram_eidi@yahoo.com
Eidi
Maryam
M
Mahmoodi
Gelavij
G
Oryan
Shahrbanoo
S
D000818:Animals; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D018721:Muscarinic Agonists / Q000627:therapeutic use; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D009538:Nicotine / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000627:therapeutic use; D018733:Nicotinic Antagonists / Q000627:therapeutic use; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology; D014810:Vitamin E / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
D018721:Muscarinic Agonists; D018727:Muscarinic Antagonists; D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D014815:Vitamins; D010862:Pilocarpine; D014810:Vitamin E; D008464:Mecamylamine; D009538:Nicotine; D012601:Scopolamine