Dissemination of CTX-M-type extended-spectrum beta-lactamase genes to unusual hosts.
A Citrobacter amalonaticus and a Morganella morganii producing the CTX-M-1 extended-spectrum beta-lactamase (ESBL) were isolated from an area where this enzyme is now widespread in Escherichia coli. This is the first report of CTX-M-1 in the former species. In both cases the ESBL determinant was possibly acquired by these unusual hosts in vivo, after coinfection with E. coli strains carrying conjugative plasmids encoding CTX-M-1.
Mugnaioli
Claudia
C
Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Università di Siena, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Luzzaro
Francesco
F
De Luca
Filomena
F
Brigante
Gioconda
G
Amicosante
Gianfranco
G
Rossolini
Gian Maria
GM
D002954:Citrobacter / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D003227:Conjugation, Genetic; D006801:Humans; D008826:Microbial Sensitivity Tests; D020613:Morganella morganii / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D010957:Plasmids; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
C055184:beta-lactamase TEM-3; D001618:beta-Lactamases