title: Molarless-induced changes of spines in hippocampal region of SAMP8 mice.
abstract: We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses.
authors.affiliation: Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan. kubo@dent.asahi-u.ac.jp
authors.forename: Kin-Ya
authors.initials: KY
authors.lastname: Kubo
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Iwaku
authors.forename: Kazuko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fujita
authors.forename: Minoru
authors.initials: M
authors.lastname: Onozuka
mesh_terms: D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D049229:Dendritic Spines / Q000502:physiology* / Q000648:ultrastructure; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008963:Molar / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure; D011930:Reaction Time; D016622:Silver Staining / Q000379:methods; D013997:Time Factors