title: [Selection of the receptor fluid based on main drug' s dissolvability in the in-vitro skin permeation study].
abstract: OBJECTIVE
  To select the receptor fluid used in the in-vitro skin permeation study of CVD from Shuxin transdermal patch.
  
  
  METHODS
  The saturated concentration of CVD in different receptor fluid was determined by RP-HPLC with precolumn ultraviolet derivatization. And the selection of receptor fluid was based on main drug's dissolvability.
  
  
  RESULTS
  The concentration of CVD in 30% ethanol/physiological saline was the highest among seven kinds of receptor fluid.
  
  
  CONCLUSIONS
  The method used to select the receptor fluid based on main drug's dissolvability in the in-vitro skin permeation study is credible and convenient.
authors.affiliation: Guangzhou University of TCM, Guangzhou 510405.
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.forename: Liling
authors.initials: L
authors.lastname: Zhou
authors.forename: Chunqing
authors.initials: C
authors.lastname: Huang
authors.forename: Yingying
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000279:Administration, Cutaneous; D000470:Alkaloids / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D000431:Ethanol; D066298:In Vitro Techniques; D010539:Permeability; D010946:Plants, Medicinal / Q000737:chemistry*; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012965:Sodium Chloride; D012995:Solubility; D012997:Solvents / Q000493:pharmacokinetics*
chemical_list: D000470:Alkaloids; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D012997:Solvents; D000431:Ethanol; D012965:Sodium Chloride