title: Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells.
abstract: Little has been reported on the drugs inducing production of monocyte-derived cytokines like interleukin (IL)-18 and IL-12. We found that nafamostat mesilate elicits IL-12, IL-18, tumor necrosis factor-alpha and interferon-gamma production, and the expression of intercellular adhesion molecules-1, B7.1, B7.2, CD40, and CD40 ligand in human peripheral blood mononuclear cells. The cytokine production and adhesion molecule expression were abolished by anti-IL-12 and IL-18 antibodies. Therefore, IL-18 and IL-12 may play roles in the significant and immediate effects of nafamostat mesilate.
authors.affiliation: Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japn.
authors.forename: Goutarou
authors.initials: G
authors.lastname: Katsuno
authors.forename: Hideo K
authors.initials: HK
authors.lastname: Takahashi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwagaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizuno
authors.forename: Shuji
authors.initials: S
authors.lastname: Mori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishibori
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D001550:Benzamidines; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis*; D020382:Interleukin-18 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear
chemical_list: D001550:Benzamidines; D006146:Guanidines; D020382:Interleukin-18; D018664:Interleukin-12; C032855:nafamostat