Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases.
OBJECTIVE
The objective of this study was to assess the role of stereotactic radiosurgery in the management of newly diagnosed multiple intracranial metastases from known primary cancer locations.


METHODS
Fifty (29 women and 21 men) patients received radiosurgery for newly diagnosed 3 or more metastatic brain tumors. Their mean age was 53 years. Lung cancer was the most common primary cancer (66%).


RESULTS
Arrest in the growth of irradiated tumors was achieved in 41 (82%) patients. Eight patients (16%) required further intervention for tumors in other brain locations. Mean survival after diagnosis of brain disease was 12 months and the brain disease-controlled period was 19 months. The period of brain disease control prolonged (P=.03) with decreasing tumor volumes (<10 mL). Control of treated tumors positively affected survival after diagnosis of brain disease (P=.0001).


CONCLUSIONS
Radiosurgery as an adjuvant improves survival in patients with cancer who have newly diagnosed multiple intracranial metastases by arresting the growth of tumors.
Jawahar
Ajay
A
Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA. ajawah@lsuhsc.edu
Shaya
Mark
M
Campbell
Peter
P
Ampil
Federico
F
Willis
Brian K
BK
Smith
Donald
D
Nanda
Anil
A
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D017567:Karnofsky Performance Status; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D016634:Radiosurgery; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome