title: DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification.
abstract: Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.
authors.affiliation: Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. buryanov@fibkh.serpukhov.su
authors.forename: Ya I
authors.initials: YI
authors.lastname: Buryanov
authors.forename: T V
authors.initials: TV
authors.lastname: Shevchuk
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D015254:DNA Modification Methylases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA
chemical_list: D004247:DNA; D015254:DNA Modification Methylases