Development of multifunctional polymer-mineral composite materials for bone tissue engineering.
The main goal of this article is the development of a novel approach to construct multifunctional composite scaffolds for bone tissue engineering. For this purpose, different kinds of mineral macroporous supports, water-soluble aldehyde-containing copolymers of N-vinylpyrrolidone, as well as different nonspecific and biospecific ligands governing cell adhesion and growth have been used. The composite materials were tested initially for cytotoxicity in cell culture experiments using a model cell line.
Vlakh
Evgenia G
EG
Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russia.
Panarin
Evgeniy F
EF
Tennikova
Tatiana B
TB
Suck
Kirstin
K
Kasper
Cornelia
C
D000327:Adsorption; D018786:Bone Substitutes / Q000737:chemistry* / Q000378:metabolism; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008239:Lysine / Q000737:chemistry; D008903:Minerals / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism; D023822:Tissue Engineering / Q000379:methods*
D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D008903:Minerals; D011108:Polymers; D011760:Pyrrolidinones; C042670:N-vinyl-2-pyrrolidinone; D008239:Lysine