[Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro].
OBJECTIVE
To study the chemical constituents in roots of P. fallax and their anti-oxidation activities in vitro.


METHODS
Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant. The structures were elucidated on the basis of the spectral evidence and the physical and chemical character. The isolated compounds were screened with four anti-oxidation models in vitro.


RESULTS
Seven xanthones, 1,7-dihydroxy-2,3-methylenedioxyxanthone (1), 1-methoxy-2,3-methylenedioxyxanthone (2), 3-hydroxy-1,2-dimethoxyxanthone (3), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (4), 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (5), 1,3-dihydroxy-2-methoxyxanthone (6) and 1,3,7-trihydroxy-2-methoxyxanthone (7), were isolated from the roots of P. fallax. And compounds 1 - 7 showed different anti-oxidation activities in the different pharmacological models.


CONCLUSIONS
Compounds 2, 3, 5 and 7 were isolated from this plant for the first time. Xanthones from this plant showed anti-oxidation activities. The pharmacological activities of the pure compounds from this plant were also reported for the first time.
Lin
Li-Lin
LL
Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100094, China.
Huang
Feng
F
Chen
Si-Bao
SB
Yang
Da-Jian
DJ
Chen
Shi-Lin
SL
Yang
Jun-Shan
JS
Xiao
Pei-Gen
PG
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008264:Macrophages / Q000502:physiology; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031801:Polygala / Q000737:chemistry*; D051381:Rats; D016897:Respiratory Burst / Q000187:drug effects; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology
C511009:1-methoxy-2,3-methylenedioxyxanthone; D000975:Antioxidants; D044004:Xanthones