title: Serotonin transporter gene polymorphism and migraine in the Korean population.
abstract: OBJECTIVE
  To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans.
  
  
  BACKGROUND
  The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake.
  
  
  METHODS
  This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5-HTT gene-linked polymorphic region (5-HTTLPR) and migraine. Using PCR techniques, the products of the 484-base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (l).
  
  
  RESULTS
  The genotype distribution of the healthy controls was s/s (56.5%), s/l (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5-HTTLPR between the patients with migraine and the control subjects.
  
  
  CONCLUSIONS
  A 5-HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.
authors.affiliation: Department of Neurology, Hallym University, Kangdong Sacred Heart Hospital, Seoul Korea.
authors.forename: Woo-Kyung
authors.initials: WK
authors.lastname: Kim
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Won-Joo
authors.initials: WJ
authors.lastname: Kim
authors.forename: Kyung-Yul
authors.initials: KY
authors.lastname: Lee
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
authors.forename: Chan-Hyung
authors.initials: CH
authors.lastname: Kim
authors.forename: Se Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins