title: Initial experience of videocapsule endoscopy for diagnosing small-bowel tumors in patients with GI polyposis syndromes.
abstract: BACKGROUND
  Small-bowel tumors frequently occur in familial adenomatous polyposis and other GI polyposis syndromes. These tumors are difficult to detect with conventional techniques. Our aim was to assess the utility of videocapsule endoscopy in the detection of small-bowel tumors in this setting.
  
  
  METHODS
  We examined 19 familial adenomatous polyposis patients and 3 patients with either Peutz-Jeghers syndrome, hyperplastic polyposis, or Cowden disease.
  
  
  METHODS
  Prevalence of small-bowel polyps on videocapsule endoscopy was 59% in all patients, 52.6% in familial adenomatous polyposis patients, and 75% in a subgroup of familial adenomatous polyposis patients with exon 15 mutations. Videocapsule endoscopy was safe and well tolerated in all patients.
  
  
  CONCLUSIONS
  Videocapsule endoscopy has a high yield in detecting small-bowel tumors in patients with GI polyposis syndromes. It may be especially indicated in familial adenomatous polyposis patients with the aggressive phenotype of the disease, e.g., mutations in exon 15.
authors.affiliation: Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: Olga
authors.initials: O
authors.lastname: Barkay
authors.forename: Menachem
authors.initials: M
authors.lastname: Moshkowitz
authors.forename: Zvi
authors.initials: Z
authors.lastname: Fireman
authors.forename: Eliahu
authors.initials: E
authors.lastname: Shemesh
authors.forename: Orit
authors.initials: O
authors.lastname: Goldray
authors.forename: Miri
authors.initials: M
authors.lastname: Revivo
authors.forename: Ada
authors.initials: A
authors.lastname: Kessler
authors.forename: Zamir
authors.initials: Z
authors.lastname: Halpern
authors.forename: Avi
authors.initials: A
authors.lastname: Orr-Urtreger
authors.forename: Nadir
authors.initials: N
authors.lastname: Arber
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014741:Video Recording