title: Comparative genomic hybridization in extramammary Paget's disease.
abstract: BACKGROUND
  Extramammary Paget's disease (EMPD) is a distinct skin cancer of unknown histogenesis. Data from genome-wide surveys for chromosomal aberrations in EMPD are limited.
  
  
  OBJECTIVE
  To identify chromosomal aberrations that are present in EMPD.
  
  
  METHODS
  Fifteen cases of EMPD were analysed by comparative genomic hybridization (CGH). We used pooled DNA CGH, instead of studying a single sample. In addition, immunohistochemistry was performed for detection of androgen receptor (AR).
  
  
  RESULTS
  The most recurrent change was amplification at chromosomes Xcent-q21 and 19, and loss at 10q24-qter. In addition, expression of AR, located in chromosome X, was found in six cases.
  
  
  CONCLUSIONS
  Results suggest that AR may play a role in EMPD tumorigenesis.
authors.affiliation: Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-Dong, Songpa-Gu, Seoul 138-736, Korea. miumiu@www.amc.seoul.kr
authors.forename: M-W
authors.initials: MW
authors.lastname: Lee
authors.forename: K-J
authors.initials: KJ
authors.lastname: Jee
authors.forename: G-Y
authors.initials: GY
authors.lastname: Gong
authors.forename: J-H
authors.initials: JH
authors.lastname: Choi
authors.forename: K-C
authors.initials: KC
authors.lastname: Moon
authors.forename: J-K
authors.initials: JK
authors.lastname: Koh
mesh_terms: D002869:Chromosome Aberrations; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009693:Nucleic Acid Hybridization / Q000379:methods; D010145:Paget Disease, Extramammary / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm