title: [Study on liver targeted drug delivery system of the effective anticancer component from Bolbstemma paniculatum].
abstract: OBJECTIVE
  To study the liver targeted drug delivery system of TBMS--the effective anticancer component from Bolbstemma paniculatum, and to discuss the system's function of decreasing toxicity.
  
  
  METHODS
  BCA was used as carrier material. The preparation through overall feedback dynamic techniques. The properties of preparation and toxicology were also technology of nanoparticles was optimized studied. Thenanoparticles' targeting in mice vivo was observed with transmission electron microscopy. The function of decreasing toxicity was researched by the XXTX-2000 automatic quantitative analysis management system.
  
  
  RESULTS
  D50 was 0.68 microm. Drug-loading rate and entrapment rate were 37.3% and 88.6% respectively. The release in vitro accorded with Weibull equation. The reaching release balance time and the t 1/2 extended 26 times and 19 times respectively comparing with injection. Nanoparticles mainly distributed in liver tissue. Their toxicity to lung and liver was evidently lower than injection. Nanoparticles' LD50 exceeded injection's by 13.5% and their stimulus was much lower than injection.
  
  
  CONCLUSIONS
  The TBMS can be targeted to liver by liver targeted drug delivery system. At the same time, the problem about the toxicity hindering clinical application could be solved, which lays the foundation for the further studies on TBMS.
authors.affiliation: West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Yi-Yi
authors.initials: YY
authors.lastname: Sun
authors.forename: Tong-Hui
authors.initials: TH
authors.lastname: Ll
authors.forename: Chen-Kang
authors.initials: CK
authors.lastname: Tang
authors.forename: Zi-Ping
authors.initials: ZP
authors.lastname: Zhu
authors.forename: Qun
authors.initials: Q
authors.lastname: Chi
authors.forename: Shi-Xiang
authors.initials: SX
authors.lastname: Hou
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019662:Cucurbitaceae / Q000737:chemistry; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005079:Excipients; D008099:Liver / Q000378:metabolism*; D051379:Mice; D049329:Nanostructures; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D027343:Rhizome / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005079:Excipients