Management of antiretroviral therapy in neonates, children, and adolescents.
There have been tremendous advances in the prevention of maternal-to-child transmission of HIV and treatment of HIV-infected children and adolescents. Although multiple classes of anti-HIV drugs are available that can control viral replication and stabilize immune function when used in combination, patients and their providers must also manage complex and frequently toxic regimens. This article updates our original report that summarizes official National Institutes of Health guidelines for the prevention of perinatal HIV infection and the management of pediatric and adolescent HIV infection and provides the most current updates on indications for therapy, recommended first-line therapy, criteria for changing therapy, salvage therapy, novel management strategies, and a comprehensive summary of available antiretroviral agents.
Neely
Michael
M
Division of Pediatric Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90041, USA. mneely@usc.edu
Kovacs
Andrea
A
D000293:Adolescent; D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D016879:Salvage Therapy; D014481:United States / Q000453:epidemiology
D044966:Anti-Retroviral Agents