title: The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors.
abstract: BACKGROUND
  It has been reported previously that the combined loss of chromosomal arms 1p and 19q is a significant predictor of outcome for patients with anaplastic oligodendroglial (AO) tumors and that such chromosomal loss correlates with classic histology in AO. The authors sought to determine whether histology was an equivalent or superior predictor of outcome compared with 1p/19q status in 131 patients with AO tumors.
  
  
  METHODS
  The status of 1p and 19q was determined using real-time, quantitative polymerase chain reaction analysis and/or fluorescence in situ hybridization. Clinical features (response to adjuvant therapy and tumor location) and molecular genetic abnormalities (9p and 10q deletions, overexpression of p53 and epidermal growth factor receptor) were determined on available specimens. Histologic assessments for classic oligodendroglial features were performed by five neuropathologists.
  
  
  RESULTS
  Classic histology was associated closely with 1p/19q loss, as reported previously. Patients who had tumors that were considered classic by at least four of the five neuropathologists showed significantly increased progression-free and overall survival compared with the patients who had less classic tumors. The authors also tested the correlation between 1p/19q status and outcome in subsets of patients stratified according to classic tumor features. The association of 1p/19q status with survival was related closely to the presence of classic histology. Loss of 1p/19q was predictive of improved outcome only among patients who had tumors with classic histologic features.
  
  
  CONCLUSIONS
  The current results suggested that, in addition to 1p/19q status, histologic features contribute information to the prediction of outcome in patients with AO. Loss of 1p and 19q appeared to be a prognostic marker only in the subset of patients who had AO tumors with classic histologic features.
authors.affiliation: Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: J Matthew
authors.initials: JM
authors.lastname: McDonald
authors.forename: Siew Ju
authors.initials: SJ
authors.lastname: See
authors.forename: Ivo W
authors.initials: IW
authors.lastname: Tremont
authors.forename: Howard
authors.initials: H
authors.lastname: Colman
authors.forename: Mark R
authors.initials: MR
authors.lastname: Gilbert
authors.forename: Morris
authors.initials: M
authors.lastname: Groves
authors.forename: Peter C
authors.initials: PC
authors.lastname: Burger
authors.forename: David N
authors.initials: DN
authors.lastname: Louis
authors.forename: Caterina
authors.initials: C
authors.lastname: Giannini
authors.forename: Gregory
authors.initials: G
authors.lastname: Fuller
authors.forename: Sandra
authors.initials: S
authors.lastname: Passe
authors.forename: Hilary
authors.initials: H
authors.lastname: Blair
authors.forename: Robert B
authors.initials: RB
authors.lastname: Jenkins
authors.forename: Helen
authors.initials: H
authors.lastname: Yang
authors.forename: Alicia
authors.initials: A
authors.lastname: Ledoux
authors.forename: Joann
authors.initials: J
authors.lastname: Aaron
authors.forename: Ulka
authors.initials: U
authors.lastname: Tipnis
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hess
authors.forename: Ken
authors.initials: K
authors.lastname: Aldape
mesh_terms: D001483:Base Sequence; D001707:Biopsy, Needle; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D015331:Cohort Studies; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016015:Logistic Models; D019656:Loss of Heterozygosity; D008297:Male; D008969:Molecular Sequence Data; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000235:genetics* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016133:Polymerase Chain Reaction / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers