title: Syncytiotrophoblast intercellular adhesion molecule-1 expression in placental villitis of unknown cause.
abstract: OBJECTIVE
  The purpose of this study was to determine syncytiotrophoblast intercellular adhesion molecule-1 expression in villitis and in normal chorionic villi from term (37-42 weeks of gestation) placentas with or without villitis.
  
  
  METHODS
  A cross-sectional study was conducted to determine syncytiotrophoblast intercellular adhesion molecule-1 expression in villitis (n = 16) and in normal villi from placentas with or without villitis (n = 16). Villitis was diagnosed with antibodies to human leukocyte antigen-DR and CD3 and hematoxylin and eosin staining of serial sections; intercellular adhesion molecule-1 reactivity in syncytiotrophoblast was confirmed with antibodies to intercellular adhesion molecule-1 and cytokeratin.
  
  
  RESULTS
  Villitis lesions had higher syncytiotrophoblast intercellular adhesion molecule-1 expression than normal chorionic villi from placentas with (19.9% vs 3.5% villi; P < .001) or without (19.9% vs 0.31% villi; P < .001) villitis. Normal villi from placentas with villitis had higher syncytiotrophoblast intercellular adhesion molecule-1 than villi from placentas without villitis (3.5% vs 0.31% villi; P < .001).
  
  
  CONCLUSIONS
  Placentas with villitis have significantly more syncytiotrophoblast intercellular adhesion molecule-1 expression than placentas without villitis. The finding that normal villi from placentas with villitis have more syncytiotrophoblast intercellular adhesion molecule-1 than normal villi from placentas without villitis suggests that syncytiotrophoblast intercellular adhesion molecule-1 could be the first step in villitis development.
authors.affiliation: ImmunoPath, Methodist Research Institute, Clarian Health Partners, Indianapolis, IN 46202, USA. clabarrere@clarian.org
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Labarrere
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Ortiz
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Sosa
authors.forename: Gonzalo L
authors.initials: GL
authors.lastname: Campana
authors.forename: Mario
authors.initials: M
authors.lastname: Wernicke
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Baldridge
authors.forename: Colin
authors.initials: C
authors.lastname: Terry
authors.forename: Hector L
authors.initials: HL
authors.lastname: DiCarlo
mesh_terms: D002824:Chorionic Villi / Q000378:metabolism* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D010922:Placenta Diseases / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism*
chemical_list: D018799:Intercellular Adhesion Molecule-1