title: Individual changes in lamotrigine plasma concentrations during pregnancy.
abstract: Eleven pregnant women on lamotrigine (LTG) monotherapy were retrospectively reviewed. A significant decrease in the ratio of plasma LTG concentration-to-dose by 65.1% was observed during the second trimester (TM2) (p=0.0058) and by 65.8% during TM3 (p=0.0045) compared to pre-pregnancy values. Five patients experienced seizure deterioration during pregnancy. The pharmacokinetic changes display marked inter-patient variation, which stresses the importance of evaluating each woman individually by closely monitoring LTG concentrations until term.
authors.affiliation: Department of Clinical Neurophysiology 3063, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. vaiva@ofir.dk
authors.forename: Vaiva
authors.initials: V
authors.lastname: Petrenaite
authors.forename: Anne
authors.initials: A
authors.lastname: Sabers
authors.forename: Jacob
authors.initials: J
authors.lastname: Hansen-Schwartz
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D049590:Postpartum Period / Q000097:blood / Q000187:drug effects; D011247:Pregnancy / Q000097:blood* / Q000187:drug effects; D012189:Retrospective Studies; D014227:Triazines / Q000097:blood* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine