Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran.
OBJECTIVE
To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection.


METHODS
This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to fill the questionnaire and take the blood samples. All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers.


RESULTS
The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively). Twelve (11%) of all family members were HBsAg positive. Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination.


CONCLUSIONS
The prevalence of intra-familial HBV infection is lower in Nahavand of Iran compared to other studies. More attention should be paid to HBV vaccination and risk-lowering activities.
Mohammad Alizadeh
Amir Houshang
AH
Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, 7th Floor, Taleghani Hospital, Yaman Street, Evin, Tehran 19857, Iran. article@rcgld.org
Ranjbar
Mitra
M
Ansari
Shahin
S
Alavian
Seyed Moayed
SM
Shalmani
Hamid Mohaghegh
HM
Hekmat
Leila
L
Zali
Mohammad Reza
MR
D000328:Adult; D003430:Cross-Sectional Studies; D003710:Demography; D005190:Family; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology* / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011795:Surveys and Questionnaires
D006514:Hepatitis B Surface Antigens