title: Statin therapy reduces contrast-induced nephropathy: an analysis of contemporary percutaneous interventions.
abstract: OBJECTIVE
  We sought to examine whether statin therapy before percutaneous coronary intervention results in reduction in contrast-induced nephropathy (CIN). Intravascular administration of contrast media can have nephrotoxic effects, particularly in patients with baseline renal insufficiency. Along with lowering serum cholesterol, statins have pleiotropic effects in the vasculature. The effect of statin use on CIN is unknown.
  
  
  METHODS
  We studied 29409 patients who had both baseline preprocedure and peak postprocedure serum creatinine measured at the time of their percutaneous coronary intervention (PCI). Baseline demographics and creatinine profile before and after the procedure were compared between patients who received preprocedure statins and those who did not. CIN was defined as an increase in serum creatinine of < or =0.5 mg/dL.
  
  
  RESULTS
  Baseline serum creatinine was similar between the two groups. When compared with patients who did not receive preprocedure statins, patients on preprocedure statins had a lower incidence of CIN (4.37 vs 5.93, P <0.0001) and nephropathy requiring dialysis (0.32 vs 0.49, P = 0.03). After adjustments for comorbidities, preprocedure statin use was associated with a significant reduction in CIN (odds ration [OR] 0.87, 95% confidence interval [CI] 0.77-0.99, P = 0.03).
  
  
  CONCLUSIONS
  Preprocedure statin use is associated with significant reduction in CIN after contemporary PCI. This reinforces the need to initiate statin therapy before percutaneous coronary interventions.
authors.affiliation: Henry Ford Heart and Vascular Institute, Henry Ford Hospital, Detroit, Mich 48202, USA. skhanal1@hfhs.org
authors.forename: Sanjaya
authors.initials: S
authors.lastname: Khanal
authors.forename: Nizar
authors.initials: N
authors.lastname: Attallah
authors.forename: Dean E
authors.initials: DE
authors.lastname: Smith
authors.forename: Eva
authors.initials: E
authors.lastname: Kline-Rogers
authors.forename: David
authors.initials: D
authors.lastname: Share
authors.forename: Michael J
authors.initials: MJ
authors.lastname: O'Donnell
authors.forename: Mauro
authors.initials: M
authors.lastname: Moscucci
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D002318:Cardiovascular Diseases / Q000628:therapy; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011300:Preoperative Care; D011446:Prospective Studies; D012042:Registries
chemical_list: D003287:Contrast Media; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D003404:Creatinine