MicroRNAs: Loquacious speaks out.
In Drosophila, Dicer-2 requires the double-stranded RNA binding protein R2D2, to mediate the assembly of short interfering RNAs into the RNA-induced silencing complex. New data show that Dicer-1 also requires a double-stranded RNA binding protein called Loquacious for efficient microRNA-mediated gene silencing.
Leuschner
Philipp J F
PJ
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, IMBA, Vienna, Austria.
Obernosterer
Gregor
G
Martinez
Javier
J
D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D020868:Gene Silencing / Q000502:physiology*; D008957:Models, Genetic; D020365:RNA Helicases / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D034743:RNA-Induced Silencing Complex / Q000235:genetics / Q000378:metabolism*; D043244:Ribonuclease III / Q000378:metabolism
D029721:Drosophila Proteins; D034741:RNA, Small Interfering; D016601:RNA-Binding Proteins; D034743:RNA-Induced Silencing Complex; C478069:DCR-2 protein, Drosophila; D043244:Ribonuclease III; D020365:RNA Helicases