Aerobic exercise capacity in normal adolescents and those with type 1 diabetes mellitus.
OBJECTIVE
To compare the aerobic exercise capacity between normal adolescents and those with type 1 diabetes mellitus (T1DM).


METHODS
An experimental group with 72 individuals diagnosed with T1DM aged 9--20, time from diagnosis 4.9 +/- 3.6 yr, without clinical cardiopulmonary disease or anemia and a control group (C) with 46 healthy individuals aged 10--18, matched by age, weight, height, body mass index, and lean and fat mass (kg), underwent an incremental aerobic exercising test on a motorized treadmill, where gas exchange variables - peak pulmonary ventilation (VE), peak oxygen consumption (VO(2)), and carbon dioxide production (CO(2)) - as well as their heart rate (HR) and time to exhaustion were recorded.


RESULTS
Body mass composition had no significant difference between experimental and control groups, and male and female subjects had similar exercising performances. The mean of hemoglobin A1c in the control group was 5.2+/- 0.9% and in the diabetic group 8.1+/- 2.2%; p=0.000. The patients with T1DM showed lower levels of aerobic capacity than the control group. Their respective values for each variable were as follows: (i) maximal VO(2) (T1DM: 41.57+/-7.68 vs. C: 51.12+/- 9.94 mL/kg/min; p< 0.001) and (ii) maximal VE (T1DM: 76.39+/-19.93 vs. C: 96.90 +/- 25.72 mL/kg/min; p< 0.001). Patients with T1DM also had an earlier time to exhaustion (T1DM: 8.75+/-1.60 vs. 10.82+/-1.44 min).


CONCLUSIONS
Adolescent patients with T1DM showed a reduced aerobic exercising capacity when compared to healthy peers matched to anthropometric conditions. This potential condition should be taken into consideration by the time of evaluation of the aerobic performance of these patients with glycemic control level.
Komatsu
William Ricardo
WR
Diabetes Center and CEMAFE - Physical Activity and Sports Medical Center, Federal University of São Paulo, São Paulo, Brazil.
Gabbay
Mônica Andrade Lima
MA
Castro
Marise Lazaretti
ML
Saraiva
Gabriela Luporini
GL
Chacra
Antonio Roberto
AR
de Barros Neto
Turíbio Leite
TL
Dib
Sérgio Atala
SA
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D017079:Exercise Tolerance; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006339:Heart Rate; D006801:Humans; D008297:Male; D010101:Oxygen Consumption
D006442:Glycated Hemoglobin