title: The insulin-like growth factor system and markers of inflammation in adult patients with inflammatory bowel disease.
abstract: OBJECTIVE
  Catabolism and growth impairment are well-known complications of inflammatory bowel disease (IBD). Recent studies have demonstrated significant changes in the IGF system in IBD patients. The aim of the present study was to investigate correlations between the IGF system and markers of inflammation in IBD.
  
  
  METHODS
  A cross-sectional study comprising 99 IBD patients (Crohn's disease (CD, n = 50) and ulcerative colitis (UC, n = 49)). Correlations between markers of inflammation and IGF-I, IGF-II and IGFBP-3 were examined in CD and UC patients in remission and relapse. The patients were clinically scored using Crohn's Disease Activity Index (CDAI) for CD patients and Activity Index (AI) for UC patients.
  
  
  RESULTS
  In the UC group we found correlations between IGF-I and CRP (r(s) = Spearman's rho) (r(s) = -0.40, p < 0.01) and albumin (r(s) = 0.46, p < 0.001), IGFBP-3 and albumin (r(s) = 0.36, p < 0.01) and AI score (r(s) = -0.31, p < 0.05). IGF-II correlated with CRP (r(s) = -0.42, p < 0.01), IL-6 (r(s) = -0.65, p < 0.001), albumin (r(s) = 0.41, p < 0.01), AI score (r(s) = -0.30, p < 0.05) and orosomucoid (r(s) = -0.47, p < 0.001). In the CD group we found correlations between IGF-I and CRP (r(s) = -0.40, p < 0.05), and albumin (r(s) = -0.46, p < 0.01), IGFBP-3 and albumin (r = 0.36, p < 0.01). IGF-II correlated with IL-6 (r(s) = -0.65, p < 0.001), albumin (r(s) = 0.41, p < 0.01), CDAI score (r(s) = -0.30, p < 0.05) and orosomucoid (r(s) = -0.47, p < 0.001).
  
  
  CONCLUSIONS
  IGF-I, IGF-II and IGFBP-3 are correlated to albumin and IGF-I and IGF-II are correlated to CRP in IBD patients. Further, IGF-II is correlated to IL-6 in IBD patients. This may suggest a correlation between inflammation and the IGF system with involvement in muscle and bone catabolism in IBD.
authors.affiliation: Department of Medicine, Vejle Hospital, Vejle, Denmark. DocMartin@dadlnet.dk
authors.forename: M
authors.initials: M
authors.lastname: Eivindson
authors.forename: J N
authors.initials: JN
authors.lastname: Nielsen
authors.forename: H
authors.initials: H
authors.lastname: Grønbaek
authors.forename: A
authors.initials: A
authors.lastname: Flyvbjerg
authors.forename: H
authors.initials: H
authors.lastname: Hey
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000097:blood*; D003424:Crohn Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D010450:Endopeptidases / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D018972:Insulin-Like Growth Factor Binding Protein 3; D015850:Interleukin-6; D009961:Orosomucoid; D012709:Serum Albumin; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D002097:C-Reactive Protein; D010450:Endopeptidases; C080473:insulin-like growth factor binding protein-3 protease