title: Cytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp.
abstract: A new compound (1), named diaporthelactone, together with two known compounds (2 and 3) were isolated from the culture of Diaporthe sp., a marine fungus growing in the submerged rotten leaves of Kandelia candel in the mangrove nature conservation areas of Fugong, Fujian Province of China. The new compound was elucidated to be 1,3-dihydro-4-methoxy-7-methyl-3-oxo-5-isobenzofuran-carboxyaldehyde (1), which showed cytotoxic activity against KB and Raji cell lines (IC50 6.25 and 5.51 microg mL(-1), respectively). Two known compounds, 7-methoxy-4,6-dimethyl-3H-isobenzofuran-1-one (2) and mycoepoxydiene (3), were also demonstrated to exhibit cytotoxic activities for the first time. All three compounds were assessed for antimicrobial activity.
authors.affiliation: The Key Laboratory of Ministry of Education of Cell Biology and Tumor Engineering, School of Life Science, Xiamen University, Xiamen 361005, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
authors.forename: Yaojian
authors.initials: Y
authors.lastname: Huang
authors.forename: Meijuan
authors.initials: M
authors.lastname: Fang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Wang
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Wenjin
authors.initials: W
authors.lastname: Su
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000302:isolation & purification; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D002681:China; D006801:Humans; D007624:KB Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D014871:Water Microbiology
chemical_list: C508472:7-methoxy-4,6-dimethyl-3H-isobenzofuran-1-one; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001572:Benzofurans; D001952:Bridged-Ring Compounds; D007783:Lactones; D011753:Pyrones; C508471:diaporthelactone; C476085:mycoepoxydiene