title: Effects of social isolation on aging-induced orofacial movements in rats.
abstract: World population is becoming older, and aging is a common risk factor for a number of pathologies. In this respect, it is important to study possible factors that could modify alterations implicated in the process of aging. The aim of the present study is to verify the effects of social isolation on the expression of orofacial movements in adult and old rats. Adult and old rats were housed isolated for 5 days or kept in their home cages in groups of six. Before and after this period, orofacial movements and open-field general activity were evaluated. Aging-induced orofacial movements were abolished by isolation. On the other hand, isolated adult rats presented an increase in orofacial movements. General activity was decreased by aging but was not modified by isolation. Our results indicate that social isolation produces different effects in adult and old rats, and these effects are specific for orofacial movements and not related to a decrease in general motor activity.
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, Edifício José Leal Prado, Brazil.
authors.forename: V P
authors.initials: VP
authors.lastname: Ricardo
authors.forename: R
authors.initials: R
authors.lastname: Frussa-Filho
authors.forename: R H
authors.initials: RH
authors.lastname: Silva
authors.forename: G B
authors.initials: GB
authors.lastname: Lopez
authors.forename: C L
authors.initials: CL
authors.lastname: Patti
authors.forename: P H
authors.initials: PH
authors.lastname: Zanier-Gomes
authors.forename: N P
authors.initials: NP
authors.lastname: Araujo
authors.forename: A J O
authors.initials: AJ
authors.lastname: Lima
authors.forename: R C
authors.initials: RC
authors.lastname: Carvalho
authors.forename: S R
authors.initials: SR
authors.lastname: Kameda
authors.forename: V C
authors.initials: VC
authors.lastname: Abílio
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005152:Facial Muscles / Q000294:innervation*; D008124:Locomotion / Q000502:physiology; D008297:Male; D008409:Mastication / Q000502:physiology; D009068:Movement / Q000502:physiology*; D051381:Rats; D011920:Rats, Inbred WF; D012934:Social Isolation; D013997:Time Factors; D014059:Tongue / Q000294:innervation / Q000502:physiology