Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileus.
We aimed to confirm the gastrokinetic effect of ghrelin analog, RC-1139, in the presence of opiates. Gastric emptying was verified in rats by counting stomach residue 15 min after gavage of methylcellulose. Normal rats: RC-1139 (0, 0.25, 1.0, 2.5 mg/kg i.v.) decreased methylcellulose left in stomach (47, 36, 12, 10% of ingested solution). Post-operative ileus (post-op. ileus) ileus: gastric residue decreased from 88 to 66, 53, 51% with RC-1139 0, 1.0, 2.5, 10 mg/kg. Morphine in post-op. ileus: gastroparesis was corrected at 10 mg/kg (54%). Ghrelin analog RC-1139 is a potent gastrokinetic in rat; it reversed gastric post-op. ileus, even in the presence of opiates.
Poitras
Pierre
P
Centre de recherche, CHUM, Hôpital Saint-Luc, 264, East René-Lévesque Blvd., Université de Montréal, Montréal, Que., Canada H2X 1P1.
Polvino
William J
WJ
Rocheleau
Bernard
B
D000818:Animals; D003243:Consciousness; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects*; D045823:Ileus / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D036361:Peptide Hormones / Q000494:pharmacology*; D011183:Postoperative Complications / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043562:Receptors, G-Protein-Coupled / Q000819:agonists; D054440:Receptors, Ghrelin
D036361:Peptide Hormones; C506432:RC-1139; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin; D009020:Morphine