title: Gastric electrical stimulation significantly increases canine lower esophageal sphincter pressure.
abstract: This study determined the effect of low-frequency and high-frequency gastric electrical stimulation (GES) on canine lower esophageal sphincter (LES) pressure and also evaluated the effect of such stimulation on neurohumoral factors that modulate LES pressure. Eight dogs were fitted with stimulation wires along the greater curvature of the stomach. A sleeve device measured LES pressure before, during, and after GES, and regulatory peptides were measured during fasting and after a meal. A consistent and significant rise in LES pressure was observed during GES, and it was sustained after GES was discontinued. Plasma concentration and area under the curve of pancreatic polypeptide, motilin, gastrin and neurotensin were not affected by GES. We conclude that acute low- and high-frequency GES significantly increases LES pressure. This effect may not be modulated by efferent vagal activity or release of regulatory peptides.
authors.affiliation: Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Xing
authors.forename: Joshua
authors.initials: J
authors.lastname: Felsher
authors.forename: Frederick
authors.initials: F
authors.lastname: Brody
authors.forename: Edy
authors.initials: E
authors.lastname: Soffer
mesh_terms: D000818:Animals; D001016:Aortic Bodies / Q000503:physiopathology; D004285:Dogs; D004525:Efferent Pathways / Q000503:physiopathology; D004558:Electric Stimulation; D049630:Esophageal Sphincter, Lower / Q000503:physiopathology*; D005215:Fasting / Q000502:physiology; D005260:Female; D008365:Manometry; D009479:Neuropeptides / Q000097:blood; D019518:Postprandial Period / Q000502:physiology; D011312:Pressure; D013997:Time Factors
chemical_list: D009479:Neuropeptides