Drug-induced hypersensitivity syndrome due to carbamazepine associated with reactivation of human herpesvirus 7.
We report a 63-year-old Japanese man with epilepsy who developed skin eruptions, liver dysfunction, high fever, leukocytosis and atypical lymphocytosis 4 weeks after he had started taking carbamazepine. Titers of human herpesvirus 7 (HHV-7)-specific IgG antibodies were significantly increased and HHV-7 DNA was detected in his serum by polymerase chain reaction. These findings suggested that reactivation of HHV-7 could contribute to the development of drug-induced hypersensitivity syndrome.
Hara
Hiroyuki
H
Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan. hhara@med.nihon-u.ac.jp
Kobayashi
Maiko
M
Yokoyama
Ai
A
Tochigi
Mizuki
M
Matsunaga
Akie
A
Shimizu
Hidenao
H
Goshima
Junko
J
Suzuki
Hiroyuki
H
D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy; D005500:Follow-Up Studies; D016199:Herpesvirus 7, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D016133:Polymerase Chain Reaction / Q000379:methods; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D018570:Risk Assessment; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000188:drug therapy; D012720:Severity of Illness Index
D004279:DNA, Viral; D002220:Carbamazepine; D011239:Prednisolone