title: [Induced sputum--means for detecting bronchial inflammation in children with atopic bronchial asthma and treatment monitoring].
abstract: Induced sputum is a very recent technique for exploration of bronchial inflammation in asthma. Since 1992, it has significantly improved as a method and as clinical and fundamental research tool for asthma. It is currently recognized that this method is well tolerated and can be used in all asthma patients, except those with FEV1 less than 11. Eosinophilic activation in asthma can be very well highlighted by cellular and biochemical analysis of expectoration. Thus, biologic arguments can be added to clinical signs in asthma exacerbations. Clinical evolution under corticosteroids can be biologically proved by this technique. Sputum analysis is useful also for differential diagnosis, sometimes difficult, between asthma and COPD.
authors.affiliation: Spitalul Clinic de Pneumoftiziologic, Secţia Pediatrie, Cluj-Napoca.
authors.forename: Ioana P
authors.initials: IP
authors.lastname: Soşa
authors.forename: Mircea
authors.initials: M
authors.lastname: Nanulescu
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D012462:Saline Solution, Hypertonic; D013183:Sputum / Q000737:chemistry / Q000166:cytology
chemical_list: D018927:Anti-Asthmatic Agents; D012462:Saline Solution, Hypertonic