title: Total synthesis of scutellarin-7-O-glucuronide.
abstract: Scutellarin-7-O-glucuronide (1) has been synthesized from 2-hydroxyl-4,5,6-trimethoxyacetophenone through eight steps, including Michael addition, cyclization, hydrogenation, hydroxyl protection, deprotection, etc. The overall yield of 13% is much higher than that reported (0.6%) by L. Farkas, G. Mezey-Vàndor et al. in 1974.
authors.affiliation: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Cui
authors.forename: Gang
authors.initials: G
authors.lastname: Fang
authors.forename: Ya-Bo
authors.initials: YB
authors.lastname: Duan
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Wu
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Zhang
authors.forename: Song
authors.initials: S
authors.lastname: Wu
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D019659:Asteraceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry; D006865:Hydrogenation
chemical_list: C504842:2-hydroxyl-4,5,6-trimethoxyacetophenone; D000098:Acetophenones; D047309:Flavones; C504841:scutellarin-7-O-glucuronide