title: [Role of proteoglycans and glycosaminoglycans in the intervertebral disc degeneration].
abstract: Proteoglycans and glycosaminoglycans are the main components of the extracellular matrix of the nucleus pulposus. Intervertebral disc degeneration due to aging and excessive mechanical loads results in adverse quantitative and structural changes to the macromolecules. Metalloproteinases induced by inflammatory mediators play a key role in degrading proteoglycans. Progressive matrix breakdown decreases water content in the disc. Dehydration compromises disc cells function and impairs resistance to compression. Biochemical changes may result in disc prolapse. Modifying the metabolism of proteoglycans and glycosaminoglycans might be an effective therapeutic strategy.
authors.affiliation: Klinika Neurochirugii, Uniwersytet Medyczny, ul. Kopcińskiego 22, 90-153 Łódź. jfort@esculap.pl
authors.forename: Jan
authors.initials: J
authors.lastname: Fortuniak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Jaskólski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Tybor
authors.forename: Piotr
authors.initials: P
authors.lastname: Komuński
authors.forename: Marek
authors.initials: M
authors.lastname: Zawirski
mesh_terms: D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism* / Q000473:pathology*; D007405:Intervertebral Disc Displacement / Q000378:metabolism / Q000473:pathology*; D011509:Proteoglycans / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D016326:Extracellular Matrix Proteins; D006025:Glycosaminoglycans; D011509:Proteoglycans; D012333:RNA, Messenger