Epitope spreading within lupus-associated ribonucleoprotein antigens.
Autoantibodies reactive with several cellular antigens are present in the sera of patients with systemic lupus erythematosus. Polypeptides within the Ro-RNP complex and the snRNP complex are often targeted by these autoantibodies. One of the mechanisms responsible for their evolution is that of epitope spreading. Experimental animal model systems provide evidence for this. This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis.
Deshmukh
Umesh S
US
Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA. usd7w@virginia.edu
Bagavant
Harini
H
Lewis
Janet
J
Gaskin
Felicia
F
Fu
Shu Man
SM
D000818:Animals; D001324:Autoantigens / Q000378:metabolism*; D000939:Epitopes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology* / Q000378:metabolism
D001324:Autoantigens; D000939:Epitopes; D012261:Ribonucleoproteins