title: Karyotypic characterization of 64 nonmalignant thyroid goiters.
abstract: Cytogenetic analyses were performed on 64 nonmalignant thyroid goiters (11 common and 53 multinodular goiters) after short-term culture. The majority of goiters (67%) were characterized by a normal karyotype, but in 5 common (45%) and 16 nodular (30%) goiters, small clones with various numerical and/or structural aberrations were found, in addition to many normal cells. Trisomy or tetrasomy 7 was the most frequent numerical aberration, seen in five cases. Deletion of 18p11 was found in four cases, and in three of them as the sole change. Selection and clonal evolution of aneuploid cells present in nonmalignant goiters could underlie progression into adenoma formation.
authors.affiliation: Department of Biology and Genetics, Medical University, Debinki str 1, 80-211 Gdańsk, Poland.
authors.forename: Mariola
authors.initials: M
authors.lastname: Iliszko
authors.forename: Alina
authors.initials: A
authors.lastname: Kuźniacka
authors.forename: Andrzej
authors.initials: A
authors.lastname: Łachiński
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Babińska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Kobierska-Gulida
authors.forename: Janusz
authors.initials: J
authors.lastname: Limon
mesh_terms: D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D006042:Goiter / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged