[Study on the effect of theaflavins on the adhesion between monocyte and endothelial cells].
The effect of theaflavins (TFs) on the adhesion between monocyte and endothelial cells induced by oxidized low density lipoprotein was studied. The experiments of cells-adhesion,the cells ELISA were applied. The results showed that TFs could significantly inhibit the adhesion between monocyte and endothelial cells, and the expression of cell adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1). That maybe one of the mechanisms in antiatheroclerosis and antiadhesion between monocyte and endothelial cells.
Lü
Hu
H
Life Science College of Jiangxi Normal University, Nanchang.
Hua
Ping
P
Yu
Jihong
J
Jiang
Xianyou
X
Leng
Heping
H
D000975:Antioxidants / Q000494:pharmacology*; D044946:Biflavonoids / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D008077:Lipoproteins, LDL; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D013662:Tea / Q000737:chemistry*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis
D000975:Antioxidants; D044946:Biflavonoids; D008077:Lipoproteins, LDL; D013662:Tea; D019010:Vascular Cell Adhesion Molecule-1; C099252:oxidized low density lipoprotein; D018799:Intercellular Adhesion Molecule-1; C056068:theaflavin; D002392:Catechin