[Effect of carbon disulfide exposure at different phases on the embryonic development in mid-pregnancy of female mice].
OBJECTIVE
To explore the sensitive point of embryotoxicity of carbon disulphide on female mice.


METHODS
At the phases of follicle developing, implanting and post-implantation of blastocyst, female mice were injected intraperitoneally with carbon disulphide 631.4 mg/kg per day for three days while controls with plant oil. All indexes were detected at the fourteenth day of pregnancy.


RESULTS
(1) In follicle developing CS(2) exposed group, the weight of embryos fossa [(1.23 +/- 0.36) g was 41% less than that in controls [(2.08 +/- 0.48) g, P = 0.000], and in implanting CS(2) exposed group the weight of embryo fossa, and embryos [(1.27 +/- 0.97) g, and (0.12 +/- 0.09) g respectively] were 39% and 37% less than those in controls [(2.08 +/- 0.48), (0.19 +/- 0.06) g, P = 0.068, P = 0.045]; (2) In both follicle developing and implanting CS(2) exposed group, the weights of uterus and placenta were also less than those in controls (P < 0.01). (3) In post-implantation CS(2) exposed group, the above parameters were not significantly different from those in controls.


CONCLUSIONS
Follicle developing phase as well as implanting of blastocyst may be sensitive point for embryotoxicity induced by carbon disulphide.
Wang
Zhi-ping
ZP
Department of Toxicology, School of Public Health, Shandong University, Jinan, Shandong Province 250012, China.
Xie
Ke-qin
KQ
Li
Hui-qing
HQ
D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity*; D010064:Embryo Implantation / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013723:Teratogens / Q000633:toxicity*
D013723:Teratogens; D002246:Carbon Disulfide