title: Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study.
abstract: BACKGROUND
  Aging of the peripheral nervous system is associated with several morphologic and functional changes, including a decrease of the nerve conduction velocity. There is evidence that these changes contribute to age-related-decline in muscle strength, sensory discrimination, and autonomic responses. The aim of this study was to characterize the decline in nerve conduction velocity in the peripheral nervous system over the aging process and to identify factors that, independent of age, affect nerve conduction velocity.
  
  
  METHODS
  We measured motor nerve conduction velocity of the right superficial peroneal nerve using a standard neurophysiologic technique in a population-based sample of subjects aged between 20 and 103 years old enrolled in the InCHIANTI study.
  
  
  RESULTS
  Average conduction velocities in the peripheral nerve decreased linearly with age in both sexes. We found that diabetes, cognitive impairment, uric acid, sIL-6R and alpha-tocopherol were significant predictors of nerve conduction velocity independently of the potential confounding effect of age, sex, sex x age interaction term, height, lymphocytes, neutrophils number, alpha1 and alpha2-globulin serum protein.
  
  
  CONCLUSIONS
  Our findings are consistent with the hypothesis that inflammation and inadequate antioxidant defenses are associated with accelerated decline of nerve conduction velocity over the aging process.
authors.affiliation: Laboratory of Clinical Epidemiology, Department of Medicine and Sciences of Aging, University G. D'Annunzio, Via dei Vestini 5, 66013 Chieti Scalo, Italy. a.diiorio@unich.it
authors.forename: Angelo
authors.initials: A
authors.lastname: Di Iorio
authors.forename: Antonio
authors.initials: A
authors.lastname: Cherubini
authors.forename: Stefano
authors.initials: S
authors.lastname: Volpato
authors.forename: Eleonora
authors.initials: E
authors.lastname: Sparvieri
authors.forename: Fulvio
authors.initials: F
authors.lastname: Lauretani
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.forename: Umberto
authors.initials: U
authors.lastname: Senin
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Abate
authors.forename: Roberto
authors.initials: R
authors.lastname: Paganelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Martin
authors.forename: Cristina
authors.initials: C
authors.lastname: Andres-Lacueva
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015415:Biomarkers; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D016000:Cluster Analysis; D016207:Cytokines / Q000097:blood; D004558:Electric Stimulation / Q000379:methods; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D017933:Peripheral Nervous System / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012737:Sex Factors; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D014810:Vitamin E