Indole-5-phenylcarbamate derivatives as human non-pancreatic secretory phospholipase A2 inhibitor.
The synthesis of the human non-pancreatic secretory phospholipase A2 inhibitor (IC(50)=1.81+/-0.59 microM) is reported.
Liu
Ying
Y
State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Physical Chemistry and College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. liuying@pku.edu.cn
Han
Xiao-feng
XF
Huang
Chang-kang
CK
Hao
Xin
X
Lai
Lu-Hua
LH
D054501:Group II Phospholipases A2; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D048448:Phenylcarbamates / Q000737:chemistry / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D013050:Spectrometry, Fluorescence
D048448:Phenylcarbamates; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2