Accuracy and limits of transpulmonary dilution methods in estimating extravascular lung water after pneumonectomy.
OBJECTIVE
The measurement of extravascular lung water index by double indicator (EVLWIdi) or the measurement of extravascular lung water index by transpulmonary thermodilution (EVLWItt) could be useful after pneumonectomy. Since pulmonary blood flow and volume are altered after pneumonectomy, the validity of these methods is uncertain. This study has compared measurements of EVLWIdi and EVLWItt with measurement of extravascular lung water index by gravimetry (EVLWIg) in a porcine model of pulmonary edema induced after right pneumonectomy.


METHODS
Randomized laboratory study.


METHODS
Animal research laboratory.


METHODS
Twenty-seven female pigs; mean weight, 35 +/- 5 kg (+/- SD).


METHODS
The pigs were anesthetized, placed on mechanical ventilation, and allocated to a two-lung group (n = 10) or a right pneumonectomy group (n = 17). EVLWIdi and EVLWItt were measured at baseline, 60 min after pneumonectomy, and 60 min after IV injection of oleic acid (OA).


RESULTS
There was a good correlation between EVLWIg and EVLWIdi values (r = 0.96, p < 0.0001 in the two-lung group; and r = 0.81, p = 0.02 in the pneumonectomy group). EVLWIdi underestimated EVLWIg in the two-lung group (- 3 mL/kg; 95% confidence interval [CI], - 7 to + 2 mL/kg) and in the pneumonectomy group (- 0.9 mL/kg; 95% CI, - 3.3 to + 1.5 mL/kg). After pneumonectomy, EVLWItt decreased in mean by 27% and increased in mean by 70% after OA acid. There was a good correlation between EVLWIg and EVLWItt values (r = 0.96, p < 0.0001 in the two-lung group; and r = 0.90, p < 0.0001 after pneumonectomy). EVLWItt slightly overestimated gravimetric value in the two-lung group (+ 1.5 mL/kg; 95% CI, - 1.5 to + 4.2 mL/kg) and largely overestimated gravimetric value after pneumonectomy (+ 5 mL/kg; 95% CI, + 3.4 to + 6.8 mL/kg).


CONCLUSIONS
Double-indicator and transpulmonary thermodilution methods could be useful in monitoring extravascular lung water index (EVLWI) after pneumonectomy, but transpulmonary thermodilution largely overestimates EVLWI.
Roch
Antoine
A
Service de Réanimation Polyvalente, Hôpitaux Sud. Antoine.Roch@mail.ap-hm.fr
Michelet
Pierre
P
D'journo
Benoit
B
Brousse
Denis
D
Blayac
Dorothee
D
Lambert
Dominique
D
Auffray
Jean-Pierre
JP
D000818:Animals; D004195:Disease Models, Animal; D015633:Extravascular Lung Water; D011013:Pneumonectomy / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000209:etiology*; D015203:Reproducibility of Results; D013552:Swine; D013815:Thermodilution / Q000379:methods