Cardiac 123I-MIBG scintigraphy in patients with drug induced parkinsonism.
Cardiac sympathetic dysfunction was investigated using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug induced parkinsonism (DIP). The mean heart to mediastinum ratio was significantly greater in patients with DIP than in those with Parkinson's disease (mean (SD): 2.07 (0.39) v 1.28 (0.15), p<0.001). MIBG uptake was not different between the DIP patients and controls. Two DIP patients whose MIBG uptake was significantly reduced showed persistent parkinsonism and responded dramatically to levodopa.
Lee
P H
PH
Department of Neurology, College of Medicine Ajou University, Woncheon-dong San 5, Paldal-ku, Suwon, Kyungki-do, 442-749, South Korea. phisland@chol.com
Kim
J S
JS
Shin
D H
DH
Yoon
S-N
SN
Huh
K
K
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000633:toxicity*; D002121:Calcium Channel Blockers / Q000633:toxicity*; D018492:Dopamine Antagonists / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000294:innervation; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011379:Prognosis; D011446:Prospective Studies; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging / Q000187:drug effects; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
D014150:Antipsychotic Agents; D002121:Calcium Channel Blockers; D018492:Dopamine Antagonists; D017256:Technetium Tc 99m Sestamibi