title: Determination of reference intervals of HbA1C (DCCT/NGSP) and HbA1C (IFCC) in adults.
abstract: OBJECTIVE
  To establish HbA1C reference intervals according to DCCT/NGSP (HbA1C DCCT/NGSP) and IFCC (HbA1C IFCC) in adults.
  
  
  METHODS
  The study was a descriptive study.
  
  
  METHODS
  The study was done in 144 subjects, with 99 males and 45 females, aged between 19 to 78 years old. All subjects had normal vital signs, physical examination, chest X-ray. Subjects who had hyperglycemia, renal problem, liver problem, anemia, and/or hemoglobinopathy were excluded from the present study.
  
  
  RESULTS
  Reference intervals of HbA1C (DCCT/NGSP) is 5.47% (4.79-6.15) and HbA1C (IFCC) is 3.66% (2.88-4.44). The authors also found very high correlation between HbA1C (DCCT/NGSP) and HbA1C (IFCC) of total, male, female, < 35 years old, and > or = 35 years old, r = 0.9995, 09997, 0.9992, 0.9988, and 0.9999, respectively.
  
  
  CONCLUSIONS
  The authors found that HbA1C (DCCT/NGSP) and HbA1C (IFCC) are not affected by sex but are influenced significantly by age group. Since HbA1C (IFCC) will be widely used in routine diabetes management, the authors recommend all laboratories provide the results of HbA1C in both DCCT/NGSP and IFCC methods during this interim period.
authors.affiliation: Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Navapun
authors.initials: N
authors.lastname: Charuruks
authors.forename: Anna
authors.initials: A
authors.lastname: Milintagas
authors.forename: Phandee
authors.initials: P
authors.lastname: Watanaboonyoungcharoen
authors.forename: Chomsri
authors.initials: C
authors.lastname: Ariyaboonsiri
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D019411:Clinical Laboratory Techniques / Q000592:standards*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012737:Sex Factors; D013223:Statistics as Topic
chemical_list: D006442:Glycated Hemoglobin