The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis.
The pathogenesis of neonatal necrotizing enterocolitis remains poorly understood. Recent evidence suggests that PAF (platelet activating factor) and human toll-like receptors (TLRs) contribute to the pro-inflammatory response that is characteristic of NEC pathology. Understanding the regulation of these molecular interactions may provide new approaches for prevention or treatment of this dreaded condition.
Caplan
Michael S
MS
Department of Pediatrics, Evanston Northwestern Healthcare and The Evanston Northwestern Healthcare Research Institute, Northwestern University, Feinberg School of Medicine, Evanston, Illinois 60201, USA. mca113@northwestern.edu
Simon
Dyan
D
Jilling
Tamas
T
D001419:Bacteria / Q000276:immunology; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D020345:Enterocolitis, Necrotizing / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D010972:Platelet Activating Factor / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
D016207:Cytokines; D010972:Platelet Activating Factor; D051193:Toll-Like Receptors