[Value of quantitative examination of urine MUC1 in bladder transitional cell carcinoma].
OBJECTIVE
To evaluate the value of quantitative examination of MUC 1 in the urine of patients with bladder transitional cell carcinoma (BTCC).


METHODS
Urine samples were obtained from 31 patients with BTCC for quantification of MUC 1 content by immunoradiometric analysis. The urine samples were also examined in 10 patients with cystitis glandularis, 10 with benign urine disease and 10 healthy volunteers. The differences in urine MUC1 content were statistically measured between the groups, between cancer patients of different clinical stages and classes, between primary and recurrent cancer patients, and between measurements taken before and after operation.


RESULTS
Urine MUC 1 was detected in all the patients. No significant differences were found between the groups, nor between patients with BTCC in all stages (P>0.05), or between primary and recurrent cancer patients (P>0.05). But MUC 1 contents showed significant difference before and after the operation in the cancer patients (P<0.05).


CONCLUSIONS
Urine MUC 1 can not serve as the marker to screen and diagnose BTCC, but it can be useful in therapeutic effect and prognostic evaluation. Specific oncogene markers are more significant than oncogene phenotype markers in clinical diagnosis and screen of BTCC.
Xiang
Song-tao
ST
Department of Urological Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China. tonyxst@163.com
Zhou
Si-wei
SW
Guan
Wei
W
Hu
Zhi-quan
ZQ
Zhuang
Qian-yuan
QY
Ye
Zhang-qun
ZQ
D002295:Carcinoma, Transitional Cell / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D018396:Mucin-1 / Q000652:urine*; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000652:urine*
D018396:Mucin-1