Viral evasion of the MHC class I antigen-processing machinery.
In their adaptation to the immune system in vertebrates, viruses have been forced to evolve elaborate strategies for evading the host's immune response. To ensure life-long persistence in the host, herpes viruses, adenoviruses and retroviruses have exploited multiple cellular pathways for their purpose, including the class I antigen-processing machinery. Attractive and prominent targets for viral attacks are the proteasome complex, the transporter associated with antigen processing, and MHC class I molecules. This review briefly outlines the different mechanisms of viral interference with the antigen-presentation pathway.
Loch
Sandra
S
Institute of Biochemistry, Biocentre, J.W. Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439 Frankfurt am Main, Germany.
Tampé
Robert
R
D018528:ATP-Binding Cassette Transporters; D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D018870:Endoplasmic Reticulum, Rough / Q000502:physiology; D005805:Genes, MHC Class I / Q000502:physiology*; D006566:Herpesviridae Infections / Q000821:virology; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology; D037521:Virulence Factors / Q000502:physiology*; D018406:Virus Physiological Phenomena
D018528:ATP-Binding Cassette Transporters; D015395:Histocompatibility Antigens Class I; D037521:Virulence Factors; C477327:transporter associated with antigen processing (TAP); D046988:Proteasome Endopeptidase Complex