title: Innovative, multifunctional sequential oligopeptide carriers Soc(n)-I and SOC(n)-II: functions-technology-perspectives.
abstract: An innovative type of multifunctional helicoid artificial carriers, formed by the repetitive Lys-Aib-Gly (SOC(n)-I) or by the Aib-Lys-Aib-Gly (SOC(n)-II), with structural rigidity and regularity were successfully applied in our laboratory for anchoring antigenic/immunogenic peptides. The carriers, designed to display a predetermined 3D structure, adopt the 3(10) helical conformation, while the attached peptides preserve their original "active" conformation. The constructed conjugates were used as substrates in solid phase immunoassays, as well as for generating potent and specific immune responses.
authors.affiliation: Laboratory of Peptide Chemistry, University of Ioannina, 45 110 Ioannina, Greece.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Alexopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Krikorian
authors.forename: Eugenia
authors.initials: E
authors.lastname: Panou-Pomonis
authors.forename: Maria
authors.initials: M
authors.lastname: Sakarellos-Daitsiotis
authors.forename: Constantinos
authors.initials: C
authors.lastname: Sakarellos
mesh_terms: D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000276:immunology; D001692:Biological Transport; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry* / Q000276:immunology* / Q000302:isolation & purification; D008666:Metalloendopeptidases / Q000235:genetics / Q000276:immunology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D001323:Autoantibodies; D018796:Immunoconjugates; D009842:Oligopeptides; D008666:Metalloendopeptidases; C055146:glycoprotein gp63, Leishmania