title: Source localisation in a real human head.
abstract: Neural activity within the human brain produces electrical potentials that are transmitted through the various tissues of the head to the scalp. A three-dimensional finite difference model has been applied to simulate this process and used as the basis for an inverse model, wherein known potentials on the scalp are used to locate sources of neural activity within the brain. The inverse model uses linear and nonlinear response functions, together with nonlinear regression to determine the source location. The model has been applied to three different simulations, and in each case was able to locate the source using a combination of linear and nonlinear response functions.
authors.affiliation: Applied Mathematics, School of Mathematical Sciences, University of Adelaide, Australia.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Teubner
authors.forename: John B
authors.initials: JB
authors.lastname: Nixon
authors.forename: Paul E
authors.initials: PE
authors.lastname: Rasser
authors.forename: Murk J
authors.initials: MJ
authors.lastname: Bottema
authors.forename: C Richard
authors.initials: CR
authors.lastname: Clark
mesh_terms: D000465:Algorithms; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D006257:Head / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008959:Models, Neurological