Association of Gly972Arg variant of insulin receptor substrate-1 with metabolic features in women with polycystic ovary syndrome.
OBJECTIVE
To examine the prevalence and the effects of Gly972Arg (G972A) variant of insulin receptor substrate-1 (IRS-1) in women with polycystic ovary syndrome (PCOS).


METHODS
Controlled clinical study.


METHODS
An academic clinical research center.


METHODS
Sixty women with PCOS and 60 control women matched for age.


METHODS
Biometric measures, metabolic and hormonal measures, genetic analyses.


METHODS
Serum androgens, glucose, and insulin were measured. Blood leukocytes were used for genetic analyses.


RESULTS
The G972A variant was encountered more often in women with PCOS. The G972A carriers were more obese than their counterparts, had higher fasting insulin levels, and were more insulin-resistant. However, androgen levels did not differ on the basis of IRS-1 genotype.


CONCLUSIONS
We observed that the G972A variant of IRS-1 was more prevalent in women with PCOS, and that it had important metabolic effects without having a direct effect on the androgen levels. However, the G972A variant of IRS-1 may modulate reproduction by lowering sex hormone-binding globulin in both healthy women and women with PCOS.
Dilek
Saffet
S
Department of Obstetrics and Gynecology, Mersin University School of Medicine, Mersin, Turkey.
Ertunc
Devrim
D
Tok
Ekrem C
EC
Erdal
Emin M
EM
Aktas
Atil
A
D000704:Analysis of Variance; D001120:Arginine / Q000235:genetics*; D001786:Blood Glucose / Q000235:genetics* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005998:Glycine / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000235:genetics*; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*
D001786:Blood Glucose; C526292:IRS1 protein, human; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D001120:Arginine; D005998:Glycine