Neutrophil homeostasis: a new role for stromal cell-derived factor-1.
Neutrophils are a key component of the innate immune response and a major contributor to inflammation. Accordingly, their number in the blood is tightly controlled. Neutrophils are normally produced exclusively in the bone marrow, and their release into the blood is tightly regulated to maintain homeostatic levels in the blood. Herein, recent evidence is reviewed showing that stromal cell-derived factor-1 (SDF-1, CXCL12) plays a key role in regulating neutrophil trafficking in the bone marrow. Moreover, studies are discussed showing that granulocyte colony-stimulating factor, primarily through regulation of SDF-1 expression in the bone marrow, plays an essential role in maintaining neutrophil homeostasis in the blood.
Link
Daniel C
DC
Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA. dlink@im.wustl.edu
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000276:immunology*; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D018448:Models, Immunological; D009154:Mutation; D009503:Neutropenia / Q000209:etiology / Q000235:genetics / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D010447:Peptide Hydrolases / Q000276:immunology; D019718:Receptors, CXCR4 / Q000235:genetics / Q000276:immunology; D013577:Syndrome
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D019718:Receptors, CXCR4; D016179:Granulocyte Colony-Stimulating Factor; D010447:Peptide Hydrolases