title: Cytological profiling: providing more haystacks for chemists' needles.
abstract: Conventional high-throughput 'chemical genetic' screening seeks to identify small-molecule inhibitors of a specific protein or pathway. A recent study describes how unbiased screening of cellular morphology, followed by affinity purification to identify targets of compounds with interesting effects, can lead to the identification of novel inhibitors.
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Lorang
authors.forename: Randall W
authors.initials: RW
authors.lastname: King
mesh_terms: D048430:Cell Shape; D002477:Cells / Q000166:cytology* / Q000378:metabolism*; D002846:Chromatography, Affinity; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical / Q000379:methods*