title: Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2.
abstract: The tissue sites of long-term herpes simplex virus type 2 (HSV-2)-specific antibody production in mice and guinea pigs were identified. In addition to secondary lymphoid tissue and bone marrow, HSV-specific plasma cells were detected in spinal cords of mice up to 10 months after intravaginal inoculation with a thymidine kinase-deficient HSV-2 strain and in lumbosacral ganglia and spinal cords of guinea pigs inoculated with HSV-2 strain MS. The long-term retention of virus-specific plasma cells in the peripheral and central nervous systems following HSV infection may be important for resistance to reinfection of neuronal tissues or may play a role in modulation of reactivation from latency.
authors.affiliation: Sealy Center for Vaccine Development, Department of Pediatrics, University of Texas Medical Branch, Galveston, 77555-0436, USA. gnmillig@utmb.edu
authors.forename: Gregg N
authors.initials: GN
authors.lastname: Milligan
authors.forename: Michael G
authors.initials: MG
authors.lastname: Meador
authors.forename: Chin-Fun
authors.initials: CF
authors.lastname: Chu
authors.forename: Christal G
authors.initials: CG
authors.lastname: Young
authors.forename: Talitha L
authors.initials: TL
authors.lastname: Martin
authors.forename: Nigel
authors.initials: N
authors.lastname: Bourne
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000918:Antibody Specificity; D017950:Ganglia, Sensory / Q000276:immunology*; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology; D051379:Mice; D010950:Plasma Cells / Q000276:immunology; D013116:Spinal Cord / Q000276:immunology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral