title: Antibiotic utilization strategies to limit antimicrobial resistance.
abstract: Antimicrobial resistance is now being recognized as a major factor determining morbidity, mortality, and cost in the intensive care unit (ICU). Various strategies to limit its spread have evolved with our understanding and are based on four basic principles: infection prevention, infection eradication, containment of resistant species, and optimization of antibiotic utilization. The optimization of antibiotic utilization, at its most basic level, is the appropriate use of antibiotics and the limitation of unnecessary antibiotic administration/exposure consisting of appropriate diagnosis, acquiring appropriate culture and sensitivity data, implementing the most appropriate treatment, selecting appropriate antibiotics, and dosing appropriately. In addition various antibiotic utilization strategies including antibiotic utilization guidelines, formulary restriction, and antibiotic cycling or rotation have evolved from our understanding of the impact of changes in antibiotic utilization on subsequent antibiotic susceptibility patterns. These strategies can be utilized as a part of a multidisciplinary approach to limit the appearance and dissemination of antimicrobial resistance in our ICUs.
authors.affiliation: Department of Surgery, University of Virginia Health Systems, Charlottesville 22908-0709, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Raymond
authors.forename: Shawn J
authors.initials: SJ
authors.lastname: Pelletier
authors.forename: Robert G
authors.initials: RG
authors.lastname: Sawyer