title: Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.
abstract: Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand (i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.
authors.affiliation: Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland. fionnuala.williams@bll.n-i.nhs.uk
authors.forename: Fionnuala
authors.initials: F
authors.lastname: Williams
authors.forename: Ashley
authors.initials: A
authors.lastname: Meenagh
authors.forename: Carole
authors.initials: C
authors.lastname: Sleator
authors.forename: Daniel
authors.initials: D
authors.lastname: Cook
authors.forename: Marcelo
authors.initials: M
authors.lastname: Fernandez-Vina
authors.forename: Anne M
authors.initials: AM
authors.lastname: Bowcock
authors.forename: Derek
authors.initials: D
authors.lastname: Middleton
mesh_terms: D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D018448:Models, Immunological; D010641:Phenotype; D011971:Receptors, Immunologic / Q000235:genetics*; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3
chemical_list: D015236:HLA-C Antigens; C093100:KIR2DL1 protein, human; C496212:KIR2DS1 protein, human; C433932:KIR2DS2 protein, human; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3