title: Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma.
abstract: The gene for insulin-like growth factor two, IGF2 is maternally imprinted. Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 promoter usage was active in eight LSCCs, among them four with LOI. As it was activated in four tumors with maintenance of imprinting (MOI) and four non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 LOI in LSCC.
authors.affiliation: Laboratory of Molecular Pathology, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka cesta 54, 10002 Zagreb, Croatia. troselj@irb.hr
authors.forename: Ivana
authors.initials: I
authors.lastname: Grbesa
authors.forename: Mirko
authors.initials: M
authors.lastname: Ivkic
authors.forename: Boris
authors.initials: B
authors.lastname: Pegan
authors.forename: Koraljka
authors.initials: K
authors.lastname: Gall-Troselj
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic
chemical_list: D007335:Insulin-Like Growth Factor II