Erythroid cells in suppressing leukemia cell growth.
This paper indicates that murine nucleated erythroid cells (EC) are able to reduce, in a dose-dependent manner, the proliferation of both L1210 lymphoma and P815 mastocytoma cells and that the leukemia cell growth inhibitory activity of unseparated bone marrow (BM) cells may be markedly augmented by their short-term culturing with erythropoietin (Epo). These results raise the intriguing possibility to utilize erythropoesis-stimulating, therapeutic strategies with the purpose of inhibiting leukemia cell growth in the body.
Seledtsov
V I
VI
Insitute of Clinical Immunology, Novosibirsk, Russia. vs@online.nsk.su
Seledtsova
G V
GV
Samarin
D M
DM
Senyukov
V V
VV
Poveschenko
O V
OV
Felde
M A
MA
Kozlov
V A
VA
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D041905:Erythroid Cells / Q000166:cytology*; D004921:Erythropoietin / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology; D007942:Leukemia, Experimental / Q000473:pathology* / Q000517:prevention & control; D051379:Mice; D008815:Mice, Inbred Strains; D014407:Tumor Cells, Cultured
D004921:Erythropoietin