Homocysteine and folate metabolism in depression.
Homocysteine is a sensitive marker of folate and vitamin B12 deficiency. Numerous studies have confirmed the association between folate deficiency and depression. It is not completely understood whether homocysteine is solely a marker for folate deficiency or if it may play a more direct role in the expression of mood disorders. This review describes the biochemical, neurochemical and clinical correlations of folate deficiency and hyperhomocysteinemia in relation to depression.
Bottiglieri
Teodoro
T
Baylor University Medical Center, Institute of Metabolic Disease, Dallas, TX 75226, USA. teodorob@baylorhealth.edu
D000818:Animals; D003863:Depression / Q000378:metabolism*; D005492:Folic Acid / Q000378:metabolism*; D006710:Homocysteine / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D020138:Hyperhomocysteinemia; D008745:Methylation; D008954:Models, Biological; D018377:Neurotransmitter Agents; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000378:metabolism
D018377:Neurotransmitter Agents; D006710:Homocysteine; D005492:Folic Acid