Delusions and hallucinations in dementia with Lewy bodies: worsening with memantine.
Three patients with probable dementia with Lewy bodies (DLB) experienced worsening delusions and visual hallucinations as a result of memantine therapy. Significant resolution occurred once treatment was discontinued. Caution is required when prescribing memantine to patients with possible DLB.
Ridha
B H
BH
Dementia Research Centre, National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK. bridha@dementia.ion.ucl.ac.uk
Josephs
K A
KA
Rossor
M N
MN
D017668:Age of Onset; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology; D018450:Disease Progression; D006212:Hallucinations / Q000139:chemically induced*; D006801:Humans; D020961:Lewy Body Disease / Q000188:drug therapy* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008559:Memantine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D010259:Paranoid Disorders / Q000139:chemically induced; D011595:Psychomotor Agitation / Q000209:etiology; D012563:Schizophrenia, Paranoid / Q000139:chemically induced*
D000978:Antiparkinson Agents; D008559:Memantine