Regulation of neutrophil apoptosis and removal of apoptotic cells.
The accumulation of neutrophils during inflammation is essential for the destruction and removal of invading microorganisms. However, for resolution of inflammation to occur, neutrophils must also be removed from the inflammatory site since these cells are capable of releasing tissue toxic molecules. Neutrophil removal has been shown to occur via apoptosis and phagocyte clearance of apoptotic cells. Therefore, manipulation of these processes is likely to be a key therapeutic strategy in the management of inflammatory disease. In this review, we examine mediators of neutrophil survival and apoptosis and the signalling pathways that regulate the balance between life and death in these cells.
Walker
Annemieke
A
MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Ward
Carol
C
Taylor
Emma L
EL
Dransfield
Ian
I
Hart
Simon P
SP
Haslett
Christopher
C
Rossi
Adriano G
AG
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002465:Cell Movement / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology