title: Intravenous rt-PA for acute stroke: comparing its effectiveness in younger and older patients.
abstract: OBJECTIVE
  To study the short and long term differences in outcome between patients > or =80 years of age and those < or =79 years of age who received intravenous recombinant tissue plasminogen activator (iv rt-PA) for acute stroke within the first 3 hours of symptom onset.
  
  
  METHODS
  We studied consecutive patients treated with iv rt-PA for acute stroke, with prospective follow up of up to 3 years. Outcome measures included National Institutes of Health Stroke Scale (NIHSS) score, Barthel Index (BI), modified Rankin score (MRS), and stroke mortality. Patients were split into two groups: younger (< or =79 years) and older (> or =80 years).
  
  
  RESULTS
  There were 65 patients in the younger cohort and 31 patients in the older. Older patients were more likely to present with more severe baseline stroke (p = 0.04; odds ratio (OR) 3.04; 95% confidence interval (CI) 1.03 to 8.98). Stroke mortality at 90 days was 10.8% in the younger and 32.3% in the older cohort (p = 0.01). At 90 days' follow up, patients in the older cohort with more severe stroke (NIHSS score > or =11) were nearly 10 times more likely to have poor outcome compared with their younger counterparts presenting with severe stroke (p = 0.001; OR = 10.36; 95% CI 2.16 to 49.20). Baseline stroke severity and age were the only independent and equal predictors for stroke outcome. No threshold was found for age or baseline stroke severity predicting outcome.
  
  
  CONCLUSIONS
  Older patients presenting with more severe baseline stroke are much less likely to benefit from iv rt-PA as compared with their younger counterparts.
authors.affiliation: Department of Medicine, Division of Neurology, University of Alberta, 2E3.13 Walter C Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada T6G 2B7.
authors.forename: M S
authors.initials: MS
authors.lastname: Mouradian
authors.forename: A
authors.initials: A
authors.lastname: Senthilselvan
authors.forename: G
authors.initials: G
authors.lastname: Jickling
authors.forename: J A
authors.initials: JA
authors.lastname: McCombe
authors.forename: D J
authors.initials: DJ
authors.lastname: Emery
authors.forename: N
authors.initials: N
authors.lastname: Dean
authors.forename: A
authors.initials: A
authors.lastname: Shuaib
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012720:Severity of Illness Index; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator