Relationship of serum interleukin-7 concentration and the coagulation state in children with nephrotic syndrome.
BACKGROUND
Enhanced platelet reactivity may play a significant role in the hypercoagulable state of nephrotic syndrome (NS). Thrombocytosis with platelet aggregation cause the release of some cytokines, among them interleukin-7 (IL-7). The aim of the study was to evaluate serum IL-7 levels in children with the symptoms of NS and to determine a correlation between its concentration and platelet count, other hemostatic factors, and NS intensity.


METHODS
The study was performed in two groups. I--the examined group of 26 children with NS (12 boys, 14 girls) aged 6.8 +/- 2.1 years, subjected to two examinations: A--before treatment, B--during treatment with prednisone (60 mg/kg 24 h after albuminuria regression); and II--the control group (C) of 20 healthy children. Serum IL-7 level was assayed by enzyme-linked immunosorbent assay method using a R & D Quantikine set.


RESULTS
In group I, IL-7 level in examination A (33.33 +/- 33.24 pg/mL) was higher than in the control subjects (P < 0.01). In examination B, IL-7 concentration was reduced to the level of 10.86 +/- 5.22 pg/mL and did not differ from the controls (P > 0.05). A positive correlation was observed between IL-7 and platelet count and serum fibrinogen level. A negative correlation was noted with antithrombin III concentration. No correlation was found with serum levels of albumin and cholesterol or urine protein.


CONCLUSIONS
In children with NS, serum IL-7 level increases proportionally to the elevated platelet count and other hemostatic components, but shows no correlation with serum albumin or urine protein.
Wasilewska
Anna
A
Department of Pediatrics, Medical University in Bialystok, Bialystok, Poland. annwasil@interia.pl
Zoch-Zwierz
Walentyna M
WM
Tomaszewska
Barbara
B
Zelazowska
Beata
B
D002648:Child; D005260:Female; D006487:Hemostasis; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D010974:Platelet Aggregation; D010976:Platelet Count; D012709:Serum Albumin / Q000032:analysis
D015851:Interleukin-7; D012709:Serum Albumin