[Clinical analysis of serum endothelin in type 2 diabetic patients with vascular complications].
OBJECTIVE
To explore the clinical significance of changes in urine microalbumin (UM) and endothelin (ET) in different courses of type 2 diabetes.


METHODS
A clinical analyses of 30 type 2 diabetic patients with vascular complications (group A) was conducted in comparison with type 2 diabetic patients without vascular complications (group B) and patients with impaired glucose tolerance (IGT, group C). With 30 healthy subjects with family history of type 2 diabetes (group D) and 30 healthy subjects without such family history (group E) as controls, UM and ET were determined in all the subjects for a statistical analysis.


RESULTS
Significant differences in UM content was noted between group A and the other 4 groups (P<0.05), while the content did not differ significantly between the latter 4 groups (P>0.05). ET content was significantly higher in group A than in the other 4 groups (P<0.01), and was the lowest in group E (P<0.01).


CONCLUSIONS
Type 2 diabetic patients sustain extensively impaired endothelium function, which is exacerbated with the progression of the disease courses. Synchronized changes between vascular complications and impaired endothelium function indicates that vascular endothelial injury relates to vascular complications and the progression of diabetes.
Fang
Yong-hong
YH
Second People's Hospital of Foshan City, Foshan 528000, China.
Zhang
Ji-ping
JP
Zhou
Shao-xiong
SX
Zheng
Ju-fen
JF
Yu
Yong-wei
YW
Yan
Shi-gang
SG
Fan
Wen-kui
WK
Chen
Yue-song
YS
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D016232:Endothelins