Morphological evaluation of the effect of d-ribose on adriamycin-evoked cardiotoxicity in rats.
The influence of d-ribose on adriamycin-induced myocardiopathy in rats was studied. Adriamycin in the cumulative dose of 25 mg/kg evoked fully developed cardiac toxicity. D-ribose in the multiple doses of 200 mg/kg did not influence ADR cardiotoxicity.
Czarnecki
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Drug Institute, 30/34 Chełmska Str., 00-725 Warsaw, Poland.
Hinek
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D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D009202:Cardiomyopathies / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D004317:Doxorubicin / Q000009:adverse effects*; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012266:Ribose / Q000008:administration & dosage*
D000903:Antibiotics, Antineoplastic; D012266:Ribose; D004317:Doxorubicin