title: Practical synthesis of unsymmetrical ureas from isopropenyl carbamates.
abstract: A very convenient method for the synthesis of unsymmetrical ureas is described, based on isopropenyl carbamates. The synthetic efficiency of traditional methods for urea formation, such as use of phosgene or alkyl and aryl carbamates, is limited by the formation of symmetrical urea side products or reaction reversibility. Isopropenyl carbamates react with amines cleanly and irreversibly and give unsymmetrical ureas in high yield and purity. This method is ideal for the rapid synthesis of compound libraries.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceutical, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA. igallou@rdg.boehringer-ingelheim.com
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gallou
authors.forename: Magnus
authors.initials: M
authors.lastname: Eriksson
authors.forename: Xingzhong
authors.initials: X
authors.lastname: Zeng
authors.forename: Chris
authors.initials: C
authors.lastname: Senanayake
authors.forename: Vittorio
authors.initials: V
authors.lastname: Farina
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D007700:Kinetics; D014508:Urea / Q000138:chemical synthesis*
chemical_list: D002219:Carbamates; D014508:Urea