Lactational transfer of cadmium from Meriones shawi shawi mothers to their pups and its effects on calcium homeostasis and bone calcium in pups.
Cadmium (Cd) was given to Meriones shawi shawi dams in the diet (1 g CdCl2/1.5 kg of diet) from day 1 to day 21 of lactation. Pups were killed at 5, 10, 14 and 21 days of lactation. Thereafter, liver, kidney, femur and stomach content were removed and plasma was collected to element analyses. Cd in stomach content, kidney, liver and femur and calcium (Ca) in stomach content, femur and plasma were determined in pups by atomic absorption spectrophotometer. The results indicate that Cd was transferred to the suckling and it was detected in the liver, the kidney and the femur from the 5th, the 10th and the 14th days of age, respectively. Stomach content of Ca was increased significantly from the 10th day to the end of lactation, whereas Ca levels increase in plasma and femur only at day 10 of lactation.
Haouem
Samir
S
Département de Physiologie, Faculté de Médecine de Monastir, Monastir, Tunisie. haouem2003@yahoo.fr
Sakly
Rachid
R
D000818:Animals; D000833:Animals, Suckling; D001842:Bone and Bones / Q000378:metabolism*; D002104:Cadmium / Q000378:metabolism / Q000493:pharmacokinetics*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D005260:Female; D005849:Gerbillinae; D007774:Lactation / Q000097:blood / Q000378:metabolism*; D008892:Milk / Q000737:chemistry*; D009928:Organ Specificity; D011897:Random Allocation; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution
D002104:Cadmium; D002118:Calcium