Mouse models created to study the pathophysiology of Type 2 diabetes.
Obesity and Type 2 diabetes have become epidemics in the Western world. Understanding the pathophysiology of the disease should help in prevention and treatment of these disorders. A common theme is the presence of insulin resistance that eventually results in Type 2 diabetes. To understand the underlying mechanisms in the progression of the disease states, investigators have created mouse models by transgenic overexpression of a candidate gene or produced gene-deletion mouse models. This review will summarize many of the more appropriate models that study insulin resistance and Type 2 diabetes.
LeRoith
Derek
D
Diabetes Branch, National Institutes of Health, Room 8D12, Building 10, Bethesda, MD 20892-1758, USA. derek@helix.nih.gov
Gavrilova
Oksana
O
D000293:Adolescent; D000818:Animals; D003923:Diabetes Mellitus, Lipoatrophic / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000502:physiology; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000502:physiology; D050417:Insulin-Secreting Cells / Q000502:physiology; D019426:Integrases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010750:Phosphoproteins / Q000502:physiology; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics; D017526:Receptor, IGF Type 1 / Q000235:genetics; D011972:Receptor, Insulin / Q000172:deficiency; D014764:Viral Proteins / Q000378:metabolism
D016326:Extracellular Matrix Proteins; C526292:IRS1 protein, human; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; C526295:Irs1 protein, mouse; D010750:Phosphoproteins; D014764:Viral Proteins; C077112:Lox protein, mouse; D008249:Protein-Lysine 6-Oxidase; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin; C045073:Cre recombinase; D019426:Integrases