Honey-induced stimulation of blood ethanol elimination and its influence on serum triacylglycerol and blood pressure in man.
The effect of honey on blood alcohol metabolism and the accompanying changes in serum triacylglycerol and blood pressure were investigated using volunteers. Fifty consenting undergraduates in apparent good health, between the ages of 15 and 30 years (23.6 +/- 7.4), were recruited for the study. The subjects were moderate alcohol drinkers (<30 g ethanol/day), matched in body weight and frame size. The participants were given ethanol (0.5 g/kg) and ethanol + honey (0.5 g/kg + 1.25 ml/kg) on two different occasions separated by 1 week. The results show that honey significantly (p < 0.01) increased blood alcohol disappearance and elimination rates by 32.4 and 28.6%, respectively, but reduced the intoxication time (that is, the time taken to attain zero blood alcohol level) and its degree (the peak blood alcohol level) by 30.0 and 4.4%. Ethanol + honey further increased serum triacylglycerol and blood pressure by 20.8 and 1.3/1.4% when compared with the proportion induced by ethanol after about 10 h of ingestion. The occasional use of honey as an anti-intoxicating agent may be approved. Meanwhile, further studies on how to ameliorate or prevent the associated increase in serum triacylglycerol and blood pressure is required.
Onyesom
I
I
Department of Medical Biochemistry, Delta State University, Abraka, Nigeria. onyesominno@yahoo.co.uk
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000435:Alcoholic Intoxication / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects*; D002957:Citrus; D018592:Cross-Over Studies; D000431:Ethanol / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D006722:Honey; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009549:Nigeria; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D000431:Ethanol