[Effect of shenqi fuzheng injection on pre/post-operational change of argyrophilic-nucleolar organizer regions in peripheral T-lymphocyte in patients with gastric carcinoma].
OBJECTIVE
To investigate the pre-post operational change of argyrophilic-nucleolar organizer regions (Ag-NORs) in peripheral T-lymphocyte of patients with gastric carcinoma (GC), and to explore the effect of shenqi fuzheng injection(SFI) on it.


METHODS
Eighty five patients were divided into two groups according to the operation performed was radical or non-radical, and the two groups were subdivided into two by additional intravenous dripping of SFI was given to them or not. The content of Ag-NORs in peripheral T-lymphocyte in all patients before and after operation as well as in 12 healthy subjects was determined.


RESULTS
Content of Ag-NORs in GC patients was significantly lower than that in the healthy subject (P < 0.01), which significantly increased after patients underwent radical operation (P < 0. 01 or P < 0.05), especially in those treated with SFI (P < 0.01). While in patients underwent non-radical operation but not treated with SFI, it showed insignificant change after operation, however it did significantly increase in those treated with SFI (P < 0.05).


CONCLUSIONS
The immune function of T lymphocyte was low in patients with gastric carcinoma, post-operational adjuvant treatment of SFI can significantly improve the cellular immunity of patients.
Yang
Jin-quiang
JQ
The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang. yangjing@163.com
Li
Yong
Y
Zhao
Qun
Q
Kuang
Gang
G
Fan
Liqiao
L
Wang
Lili
L
Zhang
Hui
H
Jiao
Kun
K
Zhou
Hongwei
H
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000378:metabolism*; D008517:Phytotherapy; D016622:Silver Staining; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal