Calcium-dependent regulation of exocytosis.
A rapid increase in intracellular calcium directly triggers regulated exocytosis. In addition, changes in intracellular calcium concentration can adjust the extent of exocytosis (quantal content) or the magnitude of individual release events (quantal size) in both the short- and long-term. It is generally agreed that calcium achieves this regulation via an interaction with a number of different molecular targets located at or near to the site of membrane fusion. We review here the synaptic proteins with defined calcium-binding domains and protein kinases activated by calcium, summarize what is known about their function in membrane fusion and the experimental evidence in support of their involvement in synaptic plasticity.
Barclay
Jeff W
JW
Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Morgan
Alan
A
Burgoyne
Robert D
RD
D000818:Animals; D002118:Calcium / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D013569:Synapses / Q000201:enzymology / Q000502:physiology
D011494:Protein Kinases; D002118:Calcium