Vaccines against veterinary helminths.
The majority of attempts to develop commercial vaccines for veterinary helminths have focussed on identifying protein antigens, which could be formulated as protective vaccines. Notable successes have been achieved for some cestode parasites, where recombinant proteins have been developed into highly effective vaccines. Although effective protection can also be obtained using some nematode proteins in their native forms, it has not yet been possible to formulate commercially successful vaccines for other helminth parasites of veterinary significance. Increasing evidence suggests that parasite glycan moieties may provide an alternative source of vaccine antigens, and increased attention is now being given to this class of compounds. In addition to identifying candidate protective antigen(s), an increased research effort is needed to develop appropriate strategies for the formulation and delivery of helminth vaccines.
Hein
W R
WR
AgReseach Limited, Wallaceville Animal Research Centre, Ward Street, Upper Hutt, New Zealand. wayne.hein@agresearch.co.nz
Harrison
G B L
GB
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D015195:Drug Design; D006374:Helminthiasis, Animal / Q000517:prevention & control*; D011134:Polysaccharides / Q000276:immunology; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D014612:Vaccines
D000947:Antigens, Helminth; D011134:Polysaccharides; D014612:Vaccines