Neutrophils and eosinophils: clinical implications of their appearance, presence and disappearance in asthma and COPD.
Asthma and chronic obstructive pulmonary disease (COPD) are common chronic disorders. Traditionally, asthma has been associated with an eosinophilic inflammation and COPD with neutrophilic inflammation. In this review we will highlight the maturation, recruitment, activation, action and apoptosis of these cells. In addition we will focus on the evidence for their presence in disease and suggest potential new therapeutic interventions.
Watt
A P
AP
Respiratory Research Group, Department of Clinical Biochemistry and Metabolic Medicine, Institute of Clinical Science, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BJ, UK.
Schock
B C
BC
Ennis
M
M
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000502:physiology; D001249:Asthma / Q000188:drug therapy / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D020556:Neutrophil Infiltration / Q000502:physiology; D009504:Neutrophils / Q000473:pathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000473:pathology*
D018927:Anti-Asthmatic Agents