Salmonella's sensor for host defense molecules.
The bacterial pathogen Salmonella typhimurium resides within phagosomes in host cells and is able to deflect the host immune response. In this issue of Cell, Bader et al. (2005) decipher an elegant mechanism by which the PhoQ sensor kinase of Salmonella is switched on by host cationic antimicrobial peptides, leading to changes in gene expression that enable Salmonella to combat the host immune response.
Hancock
Robert E W
RE
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada.
McPhee
Joseph B
JB
D023181:Antimicrobial Cationic Peptides / Q000276:immunology / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000187:drug effects* / Q000276:immunology; D015964:Gene Expression Regulation, Bacterial / Q000276:immunology / Q000502:physiology; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D011494:Protein Kinases / Q000187:drug effects / Q000276:immunology; D012486:Salmonella typhimurium / Q000201:enzymology / Q000235:genetics / Q000502:physiology*
D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; C079792:PhoQ protein, Bacteria; D011494:Protein Kinases