title: Pulmonary artery angiosarcoma: a clinicopathologic and radiological correlation.
abstract: A 69-year-old man presented with cough, shortness of breath, and fatigue. He was initially treated for allergies and then for pulmonary embolism. Radiologically, a tumor mass was found to occlude the right pulmonary artery and involve the pulmonary trunk. A right pneumonectomy was performed. Histologically, a cellular malignant spindle and epithelioid tumor with areas of necrosis and brisk mitotic activity was seen. In some areas, the tumor appeared to form vascular channels. Focal osteosarcomatous differentiation was present. Immunohistochemical studies were performed including vimentin, smooth muscle actin, desmin, CD31, CD34, S100, and pan-cytokeratin. The tumor cells were positive for CD31 and vimentin and negative for pan-cytokeratin, CD34, and S100. Two months after surgery, the patient was alive and well.
authors.affiliation: Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Huo
authors.forename: Syeling
authors.initials: S
authors.lastname: Lai
authors.forename: Gregory
authors.initials: G
authors.lastname: Gladish
authors.forename: Bogdan A
authors.initials: BA
authors.lastname: Czerniak
authors.forename: Cesar A
authors.initials: CA
authors.lastname: Moran
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D006394:Hemangiosarcoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011651:Pulmonary Artery / Q000378:metabolism / Q000473:pathology*; D019043:Vascular Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor