title: HLA-binding peptides as a therapeutic approach for chronic HIV infection.
abstract: Herein, we describe the Epimmune approach to prophylaxis and development of a multi-epitope vaccine for immunotherapy of HIV-1 infection. The central strategy of our program is to induce cellular immune responses, cytotoxic T-lymphocytes (CTL) and helper Tlymphocytes (HTL), specific for conserved epitopes from both structural and regulatory proteins of HIV-1. The HIV-1 derived and HLA-restricted CTL and HTL epitopes needed to design and construct the experimental vaccines are now known and allow for broad and non-ethnically biased coverage of the human population. The design optimization of an epitope-based DNA vaccine and evaluating methods for various DNA vaccine delivery technologies for possible use in clinical trials are addressed.
authors.affiliation: Epimmune Inc, 6555 Nacy Ridge Drive, Suite 100, San Diego, CA 92121, USA. asette@epimmune.com
authors.forename: A
authors.initials: A
authors.lastname: Sette
authors.forename: R
authors.initials: R
authors.lastname: Chesnut
authors.forename: B
authors.initials: B
authors.lastname: Livingston
authors.forename: C
authors.initials: C
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Newman