The Aging, Demographics, and Memory Study: study design and methods.
OBJECTIVE
We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and "cognitive impairment, not demented" (CIND) using a unique study design based on the nationally representative Health and Retirement Study (HRS). We also illustrate potential uses of the ADAMS data and provide information to interested researchers on obtaining ADAMS and HRS data.


METHODS
The ADAMS is the first population-based study of dementia in the United States to include subjects from all regions of the country, while at the same time using a single standardized diagnostic protocol in a community-based sample. A sample of 856 individuals age 70 or older who were participants in the ongoing HRS received an extensive in-home clinical and neuropsychological assessment to determine a diagnosis of normal, CIND, or dementia. Within the CIND and dementia categories, subcategories (e.g. Alzheimer's disease, vascular dementia) were assigned to denote the etiology of cognitive impairment.


CONCLUSIONS
Linking the ADAMS dementia clinical assessment data to the wealth of available longitudinal HRS data on health, health care utilization, informal care, and economic resources and behavior, will provide a unique opportunity to study the onset of CIND and dementia in a nationally representative population-based sample, as well as the risk factors, prevalence, outcomes, and costs of CIND and dementia.
Langa
Kenneth M
KM
Division of General Medicine, Department of Medicine, University of Michigan Health System, 300 North Ingalls Building, Rm. 7E01, Box 4029, Ann Arbor, MI 48109, USA. klanga@umich.edu
Plassman
Brenda L
BL
Wallace
Robert B
RB
Herzog
A Regula
AR
Heeringa
Steven G
SG
Ofstedal
Mary Beth
MB
Burke
James R
JR
Fisher
Gwenith G
GG
Fultz
Nancy H
NH
Hurd
Michael D
MD
Potter
Guy G
GG
Rodgers
Willard L
WL
Steffens
David C
DC
Weir
David R
DR
Willis
Robert J
RJ
D000375:Aging / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology; D003710:Demography; D004651:Employment; D004812:Epidemiologic Methods; D005500:Follow-Up Studies; D006304:Health Status; D007398:Interpersonal Relations; D008137:Longitudinal Studies; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D011153:Population; D012107:Research Design; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology