title: A case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10).
abstract: We describe an unusual case of chronic myelomonocytic leukemia with severe eosinophilia having t(5;12)(q31;p13) with t(1;7)(q10;p10). The eosinophilic proliferation was severe in peripheral blood and bone marrow, and they revealed marked dysplastic features. We performed fluorescence in situ hybridization (FISH) and immunohistochemistry to evaluate the clonality of eosinophils. The eosinophils were stained positively to platelet-derived growth factor receptor-beta. By FISH using chromosome 1 satellite probe and chromosome 1q telomere probe, the eosinophils were proved to belong to the malignant clone.
authors.affiliation: Department of Clinical Pathology, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: Myungshin
authors.initials: M
authors.lastname: Kim
authors.forename: Jihyang
authors.initials: J
authors.lastname: Lim
authors.forename: Ahwon
authors.initials: A
authors.lastname: Lee
authors.forename: Gyeongsin
authors.initials: G
authors.lastname: Park
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Kyungja
authors.initials: K
authors.lastname: Han
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Kang
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jeong-Sup
authors.initials: JS
authors.lastname: Song
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D002877:Chromosomes, Human / Q000235:genetics*; D004802:Eosinophilia / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004804:Eosinophils / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000096:biosynthesis; D014178:Translocation, Genetic
chemical_list: D020797:Receptor, Platelet-Derived Growth Factor beta