title: Glycolipids and other constituents from Desmodium gangeticum with antileishmanial and immunomodulatory activities.
abstract: Nineteen compounds of various classes, such as flavonoid glycosides, pterocarpanoids, lipids, glycolipids, and alkaloids, were isolated and identified from the Desmodium gangeticum whole plant. Aminoglucosyl glycerolipid (8) is reported here for the first time. Its structure has been elucidated by spectroscopic and degradation studies. This novel compound exhibited in vitro antileishmanial and immunomodulatory activities, as it enhanced nitric oxide (NO) production and provided resistance against infection established in peritoneal macrophages by the protozoan parasite Leishmania donovani. Another known compound, glycosphingolipid (cerebroside) (7) was found to possess significant in vitro antileishmanial and immunomodulatory activities against the same parasite. Other compounds were found to be inactive.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226001, India.
authors.forename: Pushpesh Kumar
authors.initials: PK
authors.lastname: Mishra
authors.forename: Nasib
authors.initials: N
authors.lastname: Singh
authors.forename: Ghufran
authors.initials: G
authors.lastname: Ahmad
authors.forename: Anuradha
authors.initials: A
authors.lastname: Dube
authors.forename: Rakesh
authors.initials: R
authors.lastname: Maurya
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006224:Cricetinae; D007887:Fabaceae / Q000737:chemistry*; D006017:Glycolipids / Q000302:isolation & purification* / Q000494:pharmacology; D007155:Immunologic Factors / Q000302:isolation & purification* / Q000494:pharmacology; D007893:Leishmania donovani / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology
chemical_list: D000981:Antiprotozoal Agents; D006017:Glycolipids; D007155:Immunologic Factors