title: Are we giving enough coagulation factors during major trauma resuscitation?
abstract: Hemorrhage is a major cause of trauma deaths. Coagulopathy exacerbates hemorrhage and is commonly seen during major trauma resuscitation, suggesting that current practice of coagulation factor transfusion is inadequate. Reversal of coagulopathy involves normalization of body temperature, elimination of the causes of disseminated intravascular coagulation (DIC), and transfusion with fresh-frozen plasma (FFP), platelets, and cryoprecipitate. Transfusion should be guided by clinical factors and laboratory results. However, in major trauma, clinical signs may be obscured and various factors conspire to make it difficult to provide the best transfusion therapy. Existing empiric transfusion strategies for, and prevailing teachings on, FFP transfusion appear to be based on old studies involving elective patients transfused with whole blood and may not be applicable to trauma patients in the era of transfusion with packed red blood cells (PRBCs). Perpetuation of such concepts is in part responsible for the common finding of refractory coagulopathy in major trauma patients today. In this review, we argue that coagulopathy can best be avoided or reversed when severe trauma victims are transfused with at least the equivalent of whole blood in a timely fashion.
authors.affiliation: Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.
authors.forename: Anthony M-H
authors.initials: AM
authors.lastname: Ho
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Karmakar
authors.forename: Peter W
authors.initials: PW
authors.lastname: Dion
mesh_terms: D001778:Blood Coagulation Disorders / Q000503:physiopathology / Q000517:prevention & control*; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D016913:Blood Component Transfusion / Q000379:methods*; D004211:Disseminated Intravascular Coagulation / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D010949:Plasma; D012771:Shock, Hemorrhagic / Q000503:physiopathology / Q000517:prevention & control*; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D001779:Blood Coagulation Factors