title: Cost and health status analysis after autologous chondrocyte implantation and mosaicplasty: a retrospective comparison.
abstract: OBJECTIVE
  Chondral defects of the knee cartilage are prevalent. Autologous chondrocyte implantation (ACI) and mosaicplasty are increasingly used to treat symptomatic knee defects. This study assessed the costs and health status outcomes after ACI and mosaicplasty.
  
  
  METHODS
  Patients were eligible to participate in this cross-sectional study if they received ACI or mosaicplasty at the Royal National Orthopaedic Hospital between 1997 and 2001 or were on a waiting list for ACI. Secondary-care resource use was collected to 2 years postoperatively using a resource collection proforma. Participants responded to postal questions about sociodemographic characteristics and knee-related (Modified Cincinnati Knee Rating System) and general health status (EQ-5D).
  
  
  RESULTS
  Fifty-three ACI, twenty mosaicplasty, and twenty-two patients waiting for ACI participated. The average cost per patient was higher for ACI (10,600 pounds sterling: 95 percent confidence interval [CI], 10,036 pounds sterling-11,214 pounds sterling) than mosaicplasty (7,948 pounds sterling: 95 percent CI, 6,957 pounds sterling-9,243 pounds sterling). Postoperatively, ACI and mosaicplasty patients (combined) experienced better health status than those waiting for ACI. ACI patients tended to have better health status outcomes than mosaicplasty patients (not statistically significant). Estimated average EQ-5D social tariff improvements for quality-adjusted life year (QALY) calculations were 0.23 (ACI) and 0.06 (mosaicplasty). Average costs per QALY were 23,043 pounds sterling (ACI) and 66,233 pounds sterling (mosaicplasty). The incremental cost effectiveness ratio (ICER) for providing ACI over mosaicplasty was 16,349 pounds sterling.
  
  
  CONCLUSIONS
  Average costs were higher for ACI than mosaicplasty. However, both the estimated cost per QALY and ICER for providing ACI over mosaicplasty fell beneath an implicit English funding threshold of 30,000 pounds sterling per QALY. Prospective studies should include measures of utility to confirm the estimated cost utility ratios of ACI and mosaicplasty.
authors.affiliation: Center for Health Planning and Management, Keele University, Staffordshire, UK. s.l.derrett@keele.ac.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Derrett
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stokes
authors.forename: Marilyn
authors.initials: M
authors.lastname: James
authors.forename: William
authors.initials: W
authors.lastname: Bartlett
authors.forename: George
authors.initials: G
authors.lastname: Bentley
mesh_terms: D000328:Adult; D001182:Arthroscopy / Q000191:economics* / Q000379:methods*; D019902:Chondrocytes / Q000637:transplantation*; D003365:Costs and Cost Analysis; D003430:Cross-Sectional Studies; D005260:Female; D006296:Health Services / Q000191:economics*; D006801:Humans; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D019057:Quality-Adjusted Life Years; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome