Increased seroprevalence of human herpesvirus 8 in patients with hematological disorders.
Human herpesvirus 8 (HHV8) has been consistently linked to Kaposi's sarcoma and many hematological diseases such as pleural effusion lymphoma, multicentric Castleman's disease, some lymphoproliferative diseases and posttransplantation bone marrow failure. However, whether patients with hematological disorders are at a higher risk of HHV8 infection has not been determined. In this study, indirect immunofluorescence was used to detect antibodies against lytic antigens of HHV8 in 265 patients with hematological disorders. Our data showed that 24.5% of patients (65/265) were seropositive for HHV8 IgG antibody, which was significantly higher than in our general population (p < 0.001). A significantly higher seropositive rate can be found in patients with lymphoma, leukemia, autoimmune cytopenias and myeloproliferative disorders, but not in patients with myeloma or aplastic anemia. No difference in the seropositive rate is associated with gender or age. We conclude that some patients with hematological disorders are at a higher risk of HHV8 infection.
Tsai
Wen-Hui
WH
Department and Institute of Physiology, School of Medicine, National Yang-Ming University, Taiwan.
Lee
Yuan-Ming
YM
Ing-Tiau Kuo
Benjamin
B
Ho
Chi Kuan
CK
Liao
Pen-Tung
PT
Liu
Ming-Der
MD
Kou
Yu Ru
YR
Hsu
Hui-Chi
HC
D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D005355:Fibrosis / Q000097:blood / Q000150:complications / Q000453:epidemiology; D006402:Hematologic Diseases / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000097:blood* / Q000453:epidemiology / Q000821:virology; D019288:Herpesvirus 8, Human; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012737:Sex Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G