On the role of sIL-2R measurements in rheumatoid arthritis and cancers.
A soluble IL-2 receptor (sIL-2R) is a circulating form of a membrane receptor localized on lymphoid and some cancer cells. The biological function of sIL-2R has not been completely understood. Substantially, it seems to reflect T-lymphocyte activation in diseases of different pathology. Moreover, the soluble receptor has been considered, at least in part, responsible for unsuccessful immunotherapy with IL-2 in cancers. Several lines of evidence indicate sIL-2R measurements to be useful in determining disease progress and prognosis. This review summarizes current knowledge on the sIL-2R behavior in RA and solid cancers of varied etiology.
Witkowska
Anna Maria
AM
Department of Food Commodities Science and Technology, Medical University of Bialystok, Poland. witam@amb.edu.pl
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015415:Biomarkers / Q000737:chemistry / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000737:chemistry / Q000378:metabolism*
D015415:Biomarkers; D015375:Receptors, Interleukin-2