Localization of antigenic determinants on bovine encephalitogenic protein: disease-inducing activity of fragment 44-68 in rabbits.
Region 44-68 of the basic protein of bovine central nervous system myelin is shown to have moderate encephalitogenic activity when rabbits are used as test animals. This finding is interpreted to mean that a second disease-inducing site, different from the decapeptide region enclosing residues 65-74 described by Shapira et al. (1971a) exists within region 44-89 of the encephalitogenic protein. On the other hand, we have been unable to induce clinical disease with peptide 69-89.
Bergstrand
H
H
Institute of Biochemistry 1, University of Lund, Sweden.
D020816:Amino Acid Motifs; D000818:Animals; D002417:Cattle; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D000939:Epitopes; D005260:Female; D008297:Male; D004676:Myelin Basic Protein / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology; D011817:Rabbits
D000939:Epitopes; D004676:Myelin Basic Protein; D010446:Peptide Fragments