Investigation of the bovine leukemia virus proviral DNA in human leukemias and lung cancers in Korea.
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
Lee
Jehoon
J
Department of Clinical Pathology, The Catholic University of Korea, Medical College, Korea.
Kim
Yonggoo
Y
Kang
Chang Suk
CS
Cho
Dae Hyun
DH
Shin
Dong Hwan
DH
Yum
Young Na
YN
Oh
Jae Ho
JH
Kim
Sheen Hee
SH
Hwang
Myung Sil
MS
Lim
Chul Joo
CJ
Yang
Ki Hwa
KH
Han
Kyungja
K
D000208:Acute Disease; D000230:Adenocarcinoma / Q000821:virology; D002460:Cell Line; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007723:Korea; D007938:Leukemia / Q000821:virology*; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000821:virology; D007951:Leukemia, Myeloid / Q000821:virology; D008175:Lung Neoplasms / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000821:virology; D011533:Proviruses / Q000235:genetics*
D004279:DNA, Viral