[LD isoenzyme in uterine aspirates a potential marker of endometrial cancer. Investigation of postmenopausal bleeding can be simpler and cheaper].
In diagnosing endometrial carcinoma in women with postmenopausal bleeding analysis of lactate dehydrogenase, LD, isoenzymes in uterine aspirates appeared to have 100 percent sensitivity and negative predictive value combined with high specificity and positive predictive value. Determination of the LD-profile is suggested as a marker for endometrial carcinoma in women with postmenopausal bleeding. Transvaginal ultrasonography might be combined with determination of the LD-isoenzyme profile to secure the diagnosis of endometrial malignancy in order to minimize the use of other more invasive diagnostic methods.
Niklasson
Ola
O
Kvinnokliniken, Universitetssjukhuset i Lund.
Skude
Gunnar
G
Lingman
Göran
G
Casslén
Bertil
B
Marsál
Karel
K
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008875:Middle Aged; D017698:Postmenopause; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014592:Uterine Hemorrhage / Q000175:diagnosis / Q000201:enzymology
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase