title: Prognostic impact of p53 protein overexpression in patients with node-negative lung adenocarcinoma.
abstract: Prognostic value of p53 protein expression in node-negative lung adenocarcinoma is still controversy. The expression of p53 protein was examined immunohistochemically in lung adenocarcinoma using monoclonal antibody BP53-12. A total 131 cases of primary lung adenocarcinoma were examined. Relationship between expression of p53 protein and clinicopathologic factors were studied. Overexpression of p53 protein was found in 19 patients (14.5%). Univariate and multivariate analysis showed that overexpression of p53 protein was an independent prognostic factor in node-negative lung adenocarcinoma. p53 alteration could be a valuable predictor for prognosis in node-negative lung adenocarcinoma.
authors.affiliation: Department of Surgery I, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan. hiro@fmu.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Takanori
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Takeo
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yonechi
authors.forename: Jun
authors.initials: J
authors.lastname: Ohsugi
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Higuchi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yamada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shio
authors.forename: Koichi
authors.initials: K
authors.lastname: Fujiu
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Kanno
authors.forename: Akio
authors.initials: A
authors.lastname: Ohishi
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000235:genetics*; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D016158:Genes, p53; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53