Modulation of rotational behavior in healthy volunteers by cortisol administration.
Asymmetrical turning behavior is an established indicator of asymmetrical dopaminergic activity and thought to be a manifestation of hemispatial neglect. We set out to find converging support for the hypothesis that cortisol modulates frontal dopaminergic asymmetrical activity, and hence dopaminergically mediated approach behaviors, by studying the effect of cortisol administration on turning behavior in healthy subjects. Both when our subjects attempted to rotate through a target angle (twice 360 degrees) in a clockwise or anticlockwise direction with reduced sensory input, cortisol induced a relative clockwise turning bias. Furthermore, this effect interacted with scores on novelty seeking, a putative indicator of individual differences in dopaminergic function: subjects scoring higher on novelty seeking demonstrated a smaller or no increase after cortisol administration in their clockwise turning bias. The results provide converging support for the hypothesis that cortisol modulates frontal dopaminergic asymmetrical activity. As we discuss, they further point to the possible involvement of the insula in cortisol effects.
Tops
Mattie
M
Department of Experimental and Work Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS Groningen, The Netherlands. m.tops@ppsw.rug.nl
Wijers
Albertus A
AA
Koch
Tineke
T
Korf
Jakob
J
D000328:Adult; D004292:Dominance, Cerebral / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D005106:Exploratory Behavior; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology*; D007206:Individuality; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009949:Orientation / Q000187:drug effects* / Q000502:physiology; D010468:Perceptual Disorders / Q000503:physiopathology; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D012683:Sensory Deprivation; D013223:Statistics as Topic; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
D017448:Receptors, Dopamine D2; D006854:Hydrocortisone