Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons.
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.
McKay
Leanne C
LC
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, 90095-1763, USA.
Janczewski
Wiktor A
WA
Feldman
Jack L
JL
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D007150:Immunohistochemistry / Q000379:methods; D000922:Immunotoxins / Q000633:toxicity*; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D017286:Polysomnography / Q000379:methods; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D012125:Respiratory Center / Q000293:injuries / Q000473:pathology*; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins; D012891:Sleep Apnea Syndromes / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000031:analogs & derivatives* / Q000633:toxicity; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D000922:Immunotoxins; D018040:Receptors, Neurokinin-1; D054789:Ribosome Inactivating Proteins, Type 1; C468274:substance P-saporin; D013373:Substance P; D000076985:Saporins