title: Effect of cobalt on the liver glycogen content in the streptozotocin-induced diabetic rats.
abstract: Cobalt decreases blood glucose in diabetic rats but the mechanisms involved are unclear. To determine the contribution of glycogen metabolism to glycemia-lowering effect, glycogen contents of liver and muscle in the streptozotocin-induced diabetic rats were determined. The liver glycogen was depleted in diabetic rats. But when cobalt was administered to the rats, the glycogen returned to the level of healthy rats, concomitantly with the decrease in blood glucose. The cobalt treatment had no effect on the muscle glycogen in the diabetic rats. The tissue-specific responses of glycogen metabolism suggest the involvement of suppressed glucagon signaling due to cobalt treatment.
authors.affiliation: Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata, 992-8510, Japan. ynomura@yz.yamagata-u.ac.jp
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Nomura
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Zhonggang
authors.initials: Z
authors.lastname: Feng
authors.forename: Takao
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003035:Cobalt / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008112:Liver Glycogen; D003035:Cobalt; D006003:Glycogen