Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons.
Human immunodeficiency virus (HIV)-infected patients respond poorly to hepatitis B vaccination. Records of 194 HIV-infected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P=.003).
Overton
Edgar Turner
ET
Washington University School of Medicine, St. Louis, MO 63110, USA. toverton@im.wustl.edu
Sungkanuparph
Somnuek
S
Powderly
William G
WG
Seyfried
Warren
W
Groger
Richard K
RK
Aberg
Judith A
JA
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D012367:RNA, Viral