title: The role of blood-brain barrier permeability in brain tumor imaging and therapeutics.
abstract: OBJECTIVE
  Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes.
  
  
  CONCLUSIONS
  Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Provenzale
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Mukundan
authors.forename: Mark
authors.initials: M
authors.lastname: Dewhirst
mesh_terms: D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000502:physiology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D010539:Permeability
chemical_list: D003287:Contrast Media