Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients.
Narcolepsy is a chronic sleep disorder. It is linked to the HLA-DQB1*0602 allele. A recent report established a genetic linkage between narcolepsy and the chromosomal region 4p13-q21 that contains the Clock gene. We studied two SNPs in the Clock gene aiming to find any association with narcolepsy. We did not find differences in genetic frequencies in the patients group. We concluded that these two SNPs are not associated with narcolepsy.
Moreira
Fabio
F
Instituto do Sono/Depto. de Psicobiologia, Rua Napoleão de Barros, 925, 3- andar., São Paulo, SP, Brazil.
Pedrazzoli
Mario
M
Dos Santos Coelho
Fernando Morgadinho
FM
Pradella-Hallinan
Marcia
M
Lopes da Conceição
Maria Cecília
MC
Pereira Peregrino
Alberto Jorge
AJ
de Oliveira
Emílio Carlos
EC
Tufik
Sergio
S
D001483:Base Sequence; D056926:CLOCK Proteins; D017931:DNA Primers; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D009290:Narcolepsy / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D015534:Trans-Activators / Q000235:genetics*
D017931:DNA Primers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D008562:Membrane Glycoproteins; D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human