Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer.
Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent studies demonstrate the existence of CD4+ regulatory T-cells at tumor sites, implying that these Treg cells may induce antigen-specific and local immune tolerance. This review will discuss the natural ligands and their potential roles of tumor-specific CD4+ regulatory T-cells in cancer therapy.
Wang
Rong-Fu
RF
Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA. Rongfuw@bcm.tmc.edu
D003713:Dendritic Cells / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy; D008024:Ligands; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000819:agonists / Q000378:metabolism
D008024:Ligands; D051193:Toll-Like Receptors