Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure.
We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.
Gavrisheva
N A
NA
I. P. Pavlov St. Petersburg State Medical University, Russia. na.gavrish@mail.ru
Malinin
V V
VV
Ses
T P
TP
Kozlov
K L
KL
Panchenko
A V
AV
Titkov
A Yu
AY
D000818:Animals; D002196:Capillaries / Q000166:cytology; D002199:Capillary Permeability / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D017537:Mesenteric Artery, Inferior / Q000166:cytology / Q000187:drug effects; D051381:Rats; D016212:Transforming Growth Factor beta / Q000097:blood*
D004151:Dipeptides; D016212:Transforming Growth Factor beta; C415909:lysylglutamic acid