title: Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.
abstract: The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, may be selected specifically in the infant, despite the same CTL specificity being present in the mother. Additionally, pediatric CTL activity may be compromised both by the transmission of maternal escape variants and by mother-to-child transmission of escape variants that originally arose in the father. The unique acquisition of these CTL escape forms may help to explain the severe nature of some pediatric HIV infections.
authors.affiliation: The Peter Medawar Building for Pathogen Research and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: Thillagavathie
authors.initials: T
authors.lastname: Pillay
authors.forename: Hua-Tang
authors.initials: HT
authors.lastname: Zhang
authors.forename: Jan W
authors.initials: JW
authors.lastname: Drijfhout
authors.forename: Nicola
authors.initials: N
authors.lastname: Robinson
authors.forename: Helen
authors.initials: H
authors.lastname: Brown
authors.forename: Munira
authors.initials: M
authors.lastname: Khan
authors.forename: Jagadesa
authors.initials: J
authors.lastname: Moodley
authors.forename: Miriam
authors.initials: M
authors.lastname: Adhikari
authors.forename: Katja
authors.initials: K
authors.lastname: Pfafferott
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Feeney
authors.forename: Anne
authors.initials: A
authors.lastname: St John
authors.forename: Edward C
authors.initials: EC
authors.lastname: Holmes
authors.forename: Hoosen M
authors.initials: HM
authors.lastname: Coovadia
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
authors.forename: Philip J R
authors.initials: PJ
authors.lastname: Goulder
authors.forename: Rodney E
authors.initials: RE
authors.lastname: Phillips
mesh_terms: D000595:Amino Acid Sequence; D000939:Epitopes / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D015488:HIV Antigens / Q000235:genetics; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D011247:Pregnancy; D012641:Selection, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000821:virology*
chemical_list: D000939:Epitopes; D015488:HIV Antigens; D015235:HLA-B Antigens