Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes.
We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.
Li
Chao
C
Department of Electrical Engineering, University of Southern California, Los Angeles, California 90089, USA.
Curreli
Marco
M
Lin
Henry
H
Lei
Bo
B
Ishikawa
F N
FN
Datar
Ram
R
Cote
Richard J
RJ
Thompson
Mark E
ME
Zhou
Chongwu
C
D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D043942:Nanotubes / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D017430:Prostate-Specific Antigen / Q000032:analysis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013997:Time Factors
D037742:Nanotubes, Carbon; D007204:Indium; C047711:indium oxide; D017430:Prostate-Specific Antigen