Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease.
BACKGROUND
Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1beta gene polymorphism (-511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke.


METHODS
We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1beta polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme digestion.


RESULTS
The allele T distribution did not change significantly between patients with LVD stroke and their controls nor between patients with CE stroke and their controls. The frequency of the T allele was higher in patients with SVD stroke than in the control group (37.7 vs. 30.4%, p = 0.05). After adjustment for vascular risk factor, the TT genotype was an independent risk factor for SVD stroke (OR: 2.40, 95% CI: 1.17-4.94).


CONCLUSIONS
The TT genotype of the IL-1beta gene may be associated with an increased risk of SVD stroke.
Dziedzic
Tomasz
T
Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland. Dziedzic@cm-uj.krakow.pl
Slowik
Agnieszka
A
Pera
Joanna
J
Szczudlik
Andrzej
A
D000368:Aged; D002560:Cerebrovascular Circulation; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics*
D007375:Interleukin-1