Rheological evaluation of dispersions, prepared with different non- and gamma-irradiated bioadhesive cospray dried powder mixtures.
Various polymer mixtures were used to prepare gels: native drum dried waxy maize starch, Amioca starch, Carbopol 974P NF and powder mixtures obtained by cospray drying Amioca starch and Carbopol 974P NF, and by blending Carbopol 974P NF with Amioca starch or drum dried waxy maize starch. Oscillatory rheology was employed to investigate the influence of gamma-irradiation, but also of the different compositions (i.e. Carbopol 974P NF varied from 5 to 25% w/w in the powder mixtures tested) and the preparation procedures of the powder mixtures on the viscoelastic properties of the polymer dispersions. The rheological data showed that gamma-irradiation has a significant influence on the rheological behaviour of the polymers dispersed. More elastic properties were obtained when the concentration of Carbopol 974P NF was increased. The dispersions containing at least an amount of 15% Carbopol 974P NF (w/w) are mainly elastic. Contrary to cospray drying the powders, blending the powders leads to higher elastic and gel properties of the dispersed polymers.
Bozdag
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Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmaceutical Sciences, University of Antwerp, Belgium.
Weyenberg
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Ludwig
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D000180:Acrylic Resins; D000269:Adhesives / Q000737:chemistry / Q000528:radiation effects*; D002021:Buffers; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004548:Elasticity; D005612:Freeze Drying; D005720:Gamma Rays; D010710:Phosphates / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry / Q000528:radiation effects; D011208:Powders / Q000737:chemistry / Q000528:radiation effects*; D012212:Rheology; D013213:Starch / Q000737:chemistry / Q000528:radiation effects; D014783:Viscosity
D000180:Acrylic Resins; D000269:Adhesives; D002021:Buffers; D010710:Phosphates; D011145:Polyvinyls; D011208:Powders; C006912:carboxypolymethylene; D013213:Starch