Ultrasound thrombolysis.
Cardiovascular diseases are a major cause of mortality in the developed world. Efficacy of thrombolysis plays an important role in the management of acute myocardial infarction and cerebral insult both in the acute event and in the long-term outcome of these patients. New adjunctive strategies have been tested, therefore, to make thrombolytic therapies more effective and safer. Ultrasound Thrombolysis is a technique which showed promising results under in vitro conditions and in animal studies. Now clinical trials have to prove if it is also feasible for clinical application. This report gives an overview on different technical approaches and their current performances in the clinical setting. All original articles are chronologically ordered in tables providing detailed information on each study concerning experimental design, acoustical parameters and thrombolysis outcome.
Pfaffenberger
Stefan
S
Department of Internal Medicine II, University of Vienna, Austria.
Devcic-Kuhar
Branka
B
Kastl
Stefan P
SP
Huber
Kurt
K
Maurer
Gerald
G
Wojta
Johann
J
Gottsauner-Wolf
Michael
M
D000162:Acoustics; D000818:Animals; D002404:Catheterization; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology* / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors; D014465:Ultrasonics