title: Characteristics of type 2 diabetes in terms of insulin resistance in Korea.
abstract: The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin- resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p < 0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p < 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p < 0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Yongdong Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-dong, Gangnam-gu, Seoul 135-720, Korea. acw@yumc.yonsei.ac.kr.
authors.forename: Jong-Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Chul-Sik
authors.initials: CS
authors.lastname: Kim
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Nam
authors.forename: Dol-Mi
authors.initials: DM
authors.lastname: Kim
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Jo
authors.forename: Jina
authors.initials: J
authors.lastname: Park
authors.forename: Chul-Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Bong-Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Sung-Kil
authors.initials: SK
authors.lastname: Lim
authors.forename: Kyung-Rae
authors.initials: KR
authors.lastname: Kim
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Lee
authors.forename: Kap-Bum
authors.initials: KB
authors.lastname: Huh
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin