title: [Polymorphism research on the distribution of four HLA alleles in five Chinese populations].
abstract: ARMS-SSP PCR was applied to survey the distribution of four AIDS associated HLA alleles, HLA-A*02, B*35, B*27, and B*57 in five Chinese nationalities (Yunnan han, yi, dai, Xinjiang uygur, and Guangxi zhuang). The results showed that HLA-A*02 allele occured very frequently at higher frequencies in han and zhuang than in the other three nationalities; B*35 did not show great variation in it's distribution in five population groups; B*27 had a distinctively high frequency in dai, but normal in han, yi and zhuang; B*57 allele did not vary greatly in these nationalities, too. A*02, B*27 and B*57 are three protective alleles. As a whole, their frequencies in the five nationalities were significantly different. This study could be a complement of the HLA and AIDS relative studies, and enhanced the understanding of the genetic background of some AIDS epidemic regions in China.
authors.affiliation: Department of Genetics, Institute of Medical Biology, Pekin Union Medical College, Kunming 650118, China. wy_jessie@tom.com
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Xiao
authors.forename: Jia-You
authors.initials: JY
authors.lastname: Chu
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Jian-Kun
authors.initials: JK
authors.lastname: Yu
authors.forename: Shao-Bing
authors.initials: SB
authors.lastname: Xu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens