Pseudomembranous colitis associated with chemotherapy with 5-fluorouracil.
Pseudomembranous colitis is frequently associated with antibiotics and more rarely with chemotherapeutic agents such as 5-fluorouracil. The objective of this study is to show that it is possible to confuse this infection with chemotherapy associated toxicity. We present a 54 year old woman who underwent surgery for colorectal cancer and in the first cycle of chemotherapy with 5-fluorouracil developed pseudomembranous colitis. We detected the toxin B of Clostridium difficile in stools and we began early antibiotic treatment. Thus, in patients with post chemotherapy neutropenia and diarrhoea that develop negatively, we have to rule out this infection.
Morales Chamorro
Rafael
R
Servicio de Oncología Médica, Hospital Universitario Reina Sofía, Córdoba, Spain. romancordoba@hotmail.com
Serrano Blanch
Raquel
R
Méndez Vidal
María José
MJ
Gómez España
María Auxiliadora
MA
Rubio Pérez
María Jesús
MJ
de la Haba Rodríguez
Juan Rafael
JR
Aranda Aguilar
Enrique
E
D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D016360:Clostridioides difficile; D054067:Dihydropyrimidine Dehydrogenase Deficiency; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D016867:Immunocompromised Host; D008875:Middle Aged; D012772:Shock, Septic / Q000209:etiology; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000601:surgery
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil