HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis.
Roumier
T
T
Szabadkai
G
G
Simoni
A-M
AM
Perfettini
J-L
JL
Paulau
A-L
AL
Castedo
M
M
Métivier
D
D
Badley
A
A
Rizzuto
R
R
Kroemer
G
G
D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002518:Ceramides / Q000494:pharmacology; D003587:Cytomegalovirus; D015726:Giant Cells / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017874:Immediate-Early Proteins / Q000494:pharmacology*; D051034:Inhibitor of Apoptosis Proteins / Q000494:pharmacology*; D019402:Macrophage Inflammatory Proteins / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D019888:Nelfinavir / Q000494:pharmacology; D019438:Ritonavir / Q000494:pharmacology; D019258:Saquinavir / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D014764:Viral Proteins / Q000494:pharmacology*
D002518:Ceramides; D017320:HIV Protease Inhibitors; D017874:Immediate-Early Proteins; D051034:Inhibitor of Apoptosis Proteins; D019402:Macrophage Inflammatory Proteins; D016159:Tumor Suppressor Protein p53; C420323:UL37 protein, Human herpesvirus 5; D014764:Viral Proteins; D006861:Hydrogen Peroxide; D019888:Nelfinavir; D019258:Saquinavir; D019438:Ritonavir; D002118:Calcium