title: Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients.
abstract: Of two major forms (myo- and chiro-inositol) of inositols, only chiro-inositol enhances the activity of proteins involved in intracellular glucose metabolism. This study aims to determine the urinary myo-/chiro-inositol ratio in type 1 and type 2 diabetes patients and compare its ratio with the normal control group. The 24-hour urinary myo- and chiro-inositols in 71 Korean diabetes patients and 39 control subjects have been quantified using high-performance liquid chromatography, and their ratios have been evaluated as indices of insulin resistance. The level of 24-hour urinary myo-inositol was significantly higher in both type 1 and type 2 diabetes than with the control group, whereas the urinary chiro-inositol in type 1 or type 2 diabetes was lower than that in normal subjects. The myo-/chiro-inositol ratio in diabetes patients was higher than that in the control group. Twenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance.
authors.affiliation: Department of Internal Medicine, Gyeongsang National University, Jinju 660- 702, Korea.
authors.forename: Tae-Sik
authors.initials: TS
authors.lastname: Jung
authors.forename: Jong-Ryeal
authors.initials: JR
authors.lastname: Hahm
authors.forename: Jong-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Jung-Hwa
authors.initials: JH
authors.lastname: Jung
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kang
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Moon
authors.forename: Kang-Wan
authors.initials: KW
authors.lastname: Lee
authors.forename: Ho-Cheol
authors.initials: HC
authors.lastname: Kim
authors.forename: Jong-Deog
authors.initials: JD
authors.lastname: Lee
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Deok-Ryong
authors.initials: DR
authors.lastname: Kim
authors.forename: Soon-Il
authors.initials: SI
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D005260:Female; D006801:Humans; D007294:Inositol / Q000652:urine*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
chemical_list: D007294:Inositol