Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China.
BACKGROUND
Aldosterone synthase (CYP11B2) is a key enzyme in the biosynthesis of aldosterone. Recently, a C-344T polymorphism in the promoter region of the CYP11B2 gene has been reported to be in association with high blood pressure. We investigated the association between this polymorphism and essential hypertension in Hani (n=305 individuals) and Yi (n=233 individuals) minorities of China.


METHODS
CYP11B2 genotyping with polymerase chain reaction-restriction fragment length polymorphism was performed in 267 normotensive subjects and 271 essential hypertensive subjects. At the same time, the T(-344)C polymorphism detection in 33 subjects was also performed by sequencing.


RESULTS
The frequency of CYP11B2 C-344T genotype in normotensive controls and essential hypertensive cohort in Hani population were TT: 0.729 vs. 0.610; CT + CC: 0.271 vs. 0.390, respectively. The frequency of CYP11B2 C-344T genotype in normotensive controls and essential hypertensive cohort in Yi population were TT: 0.612 vs. 0.475; CT + CC: 0.388 vs. 0.525, respectively. The frequency of CC + CT genotype in the essential hypertensive group was significantly higher than that in the normotensive controls in both Hani and Yi populations (P<0.05).


CONCLUSIONS
The -344C allele of the CYP11B2 may play a role in genetic predisposition to developing essential hypertension in Hani and Yi minorities of China.
Tang
Wenru
W
Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center of Yunnan University, #2 N. Cuihu Rd. Kunming, Yunnan 650091, PR China.
Wu
Hongyan
H
Zhou
Xuhong
X
Cheng
Baowen
B
Dong
Yongli
Y
He
Li
L
Yu
Haijing
H
Xu
Lin
L
Lu
Jing
J
Li
Kaiyuan
K
Xiao
Chunjie
C
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D019405:Cytochrome P-450 CYP11B2