title: Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy.
abstract: Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient-echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA-related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage.
authors.affiliation: Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA. jrosand@partners.org
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Alona
authors.initials: A
authors.lastname: Muzikansky
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Wisco
authors.forename: Eric E
authors.initials: EE
authors.lastname: Smith
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Betensky
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016657:Cerebral Amyloid Angiopathy / Q000150:complications* / Q000473:pathology; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged