title: Myeloid/NK cell precursor acute leukemia lost both CD13 and CD33 at first diagnosis.
abstract: It has been reported that malignancies of natural killer (NK) cell precursors, which are present in both myeloid and lymphoid antigens, are characterized by immature lymphoblastoid morphology with CD7+, CD33+ and CD56+ phenotype. Here, we report a 18-year-old man who was diagnosed with CD33- and CD13- NK cell precursor acute leukemia at first diagnosis. Following a 3-year remission state, he had a relapse as a testicular tumor and CD33+ myeloid/NK cell precursor acute leukemia after allogenic BMT. This case suggests that myeloid antigens are not necessary for diagnosis of myeloid/NK cell precursor acute leukemia.
authors.affiliation: Third Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Ogura
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Torikai
authors.forename: Takashi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Kazuo
authors.initials: K
authors.lastname: Motoyoshi
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000097:blood*; D019011:Antigens, CD7 / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D016026:Bone Marrow Transplantation; D018826:CD13 Antigens / Q000097:blood*; D019002:CD56 Antigen / Q000097:blood; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D012008:Recurrence; D063268:Sialic Acid Binding Ig-like Lectin 3; D013736:Testicular Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D014184:Transplantation, Homologous
chemical_list: D015703:Antigens, CD; D019011:Antigens, CD7; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D019002:CD56 Antigen; D063268:Sialic Acid Binding Ig-like Lectin 3; D018826:CD13 Antigens