The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO)2Ph: a potential strategy for targeting cancer cells.
DNA strand scission is produced by the ambient light photolysis of CpFe(CO)(2)Ph and H(2)O(2), a result that shows potential as a means of targeting tumors, due to the high levels of hydrogen peroxide in cancer cells. This cleavage process is dependent on the concentration of both CpFe(CO)(2)Ph and H(2)O(2), and preliminary experiments implicate both carbon-centered radicals and reactive oxygen species.
Mohler
Debra L
DL
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA. dmohler@emory.edu
Shell
Thomas A
TA
D004247:DNA / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006868:Hydrolysis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010777:Photochemistry
D004247:DNA; D006861:Hydrogen Peroxide