Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates.
Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential.
Wipf
Peter
P
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
Xiao
Jingbo
J
Jiang
Jianfei
J
Belikova
Natalia A
NA
Tyurin
Vladimir A
VA
Fink
Mitchell P
MP
Kagan
Valerian E
VE
D000818:Animals; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006096:Gramicidin / Q000138:chemical synthesis / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism
D003497:Cyclic N-Oxides; D005609:Free Radicals; D010455:Peptides; D006096:Gramicidin; C003959:TEMPO