title: Lessons from reproductive immunology for other fields of immunology and clinical approaches.
abstract: Reproduction is indispensable to evolution and, thus, life. Nonetheless, it overcomes common rules known to established life. Immunology of reproduction, and especially the tolerance of two genetically distinct organisms and their fruitful symbiosis, is one of the most imposing paradox of life. Mechanisms, which are physiologically used for induction of said tolerance, are frequently abused by pathogens or tumors intending to escape the host's immune response. Understanding the regulation of immune responses in pregnancy and the invasion of allogeneic fetus-derived trophoblast cells into the decidua may lead to new therapeutic concepts. In transplantation, knowledge concerning local physiological immunotolerance may be useful for the development of new therapies, which do not require a general immune suppression of the patient. In immunological disorders, such as autoimmune diseases or allergies, immune deviations occur which are either prevented during pregnancy or have parallels to pregnancy. Vice versa, lessons from other fields of immunology may also offer new notions for the comprehension of reproductive immunology and may lead to new therapies for the treatment of pregnancy-related problems.
authors.affiliation: Department of Obstetrics, Friedrich Schiller University, Jena, Germany.
authors.forename: Udo R
authors.initials: UR
authors.lastname: Markert
authors.forename: Justine S
authors.initials: JS
authors.lastname: Fitzgerald
authors.forename: Lydia
authors.initials: L
authors.lastname: Seyfarth
authors.forename: Joana
authors.initials: J
authors.lastname: Heinzelmann
authors.forename: Frauke
authors.initials: F
authors.lastname: Varosi
authors.forename: Sandra
authors.initials: S
authors.lastname: Voigt
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Schleussner
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Seewald
mesh_terms: D000486:Allergy and Immunology; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy; D007108:Immune Tolerance; D009369:Neoplasms / Q000276:immunology; D010271:Parasites / Q000276:immunology; D011247:Pregnancy / Q000276:immunology; D012098:Reproduction / Q000276:immunology*; D014181:Transplantation Immunology; D014780:Viruses / Q000276:immunology