terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock.
To establish the vertebrate body plan, it is fundamental to create left-right asymmetry in the lateral-plate mesoderm to correctly position the organs. However, it is also crucial to maintain symmetry between the left and the right sides of the presomitic mesoderm, ensuring the allocation of symmetrical body structures, such as the axial skeleton and skeletal muscles. Here, we show that terra is an early left-sided expressed gene that links left-right patterning with bilateral synchronization of the segmentation clock.
Saúde
Leonor
L
Instituto Gulbenkian de Ciência, Centro de Biologia do Desenvolvimento, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal. mlsaude@igc.gulbenkian.pt
Lourenço
Raquel
R
Gonçalves
Alexandre
A
Palmeirim
Isabel
I
D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D019521:Body Patterning / Q000502:physiology*; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D047108:Embryonic Development / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D008648:Mesoderm / Q000378:metabolism; D018482:Muscle, Skeletal / Q000196:embryology; D041641:Musculoskeletal Development / Q000502:physiology*; D019170:Somites / Q000166:cytology / Q000378:metabolism*; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; C486538:Dmrt2 protein, mouse; D014157:Transcription Factors