title: Olive oil based nutrition in multiple trauma patients: a pilot study.
abstract: OBJECTIVE
  A negative effect of hyperglycemia on clinical outcome has been proposed for patients treated under intensive care conditions. So far, however, the safety and effect of fat based nutrition regimen, especially of olive oil based emulsions, have not been systematically studied.
  
  
  METHODS
  Prospective, open-labeled, randomized, pilot study in a 14-bed surgical intensive care unit.
  
  
  METHODS
  Thirty-three consecutive, severe multiple trauma patients (injury severity score 31.6+/-11.5) were included; 18 (L group) received a parenteral lipid-based nutrition; 15 (G group) were given a standard parenteral glucose-based nutrition.
  
  
  RESULTS
  The energy expenditure (EE) showed no difference between groups and no significant difference between the energy intake/EE ratio. The daily mean energy intake was lower in the L group (17.9+/-6.3 kcal/kg) than in the G group (22.3+/-4.2 kcal/kg). Triglycerides and nitrogen balance showed no significant differences between groups. The L group had significantly lower blood glucose (L 7.4+/-1.6, G 8.7+/-1.6 mmol/l), carbon dioxide production, and minute volume and shorter duration of mechanical ventilation (L 13.0+/-8.9, G 20.4+/-7.0 days), and stay in the ICU (L 17.9+/-11.2, G 25.1+/-7.0 days).
  
  
  CONCLUSIONS
  Our findings suggest a good tolerance, a decrease in blood glucose, clinically relevant shortening of ICU stay, and shorter time on mechanical ventilation for patients treated with olive oil based than with conventional glucose-heavy nutrition.
authors.affiliation: Department of Anesthesiology, BG Kliniken Bergmannstrost, Merseburger Strasse 165, 06114 Halle, Germany. gerald.huschak@gmx.de
authors.forename: Gerald
authors.initials: G
authors.lastname: Huschak
authors.forename: Karsten
authors.initials: K
authors.lastname: Zur Nieden
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoell
authors.forename: Dagmar
authors.initials: D
authors.lastname: Riemann
authors.forename: Henning
authors.initials: H
authors.lastname: Mast
authors.forename: Ralph
authors.initials: R
authors.lastname: Stuttmann
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000145:classification / Q000378:metabolism / Q000628:therapy*; D000069463:Olive Oil; D010288:Parenteral Nutrition; D010865:Pilot Projects; D010938:Plant Oils; D012121:Respiration, Artificial
chemical_list: D001786:Blood Glucose; D000069463:Olive Oil; D010938:Plant Oils