title: Effects of pulsatile CPB on interleukin-8 and endothelin-1 levels.
abstract: Studies on pulsatile and nonpulsatile perfusion have long been performed. However, investigators have not reached a conclusion on which is more effective. In the present study, pulsatile cardiopulmonary bypass (CPB) was investigated in terms of the effects on cytokines, endothelin, catecholamine, and pulmonary and renal functions. Twenty-four patients who underwent coronary artery bypass grafting were divided into a pulsatile CPB group and a nonpulsatile CPB group. Parameters examined were hemodynamics, interleukin-8 (IL-8), endothelin-1 (ET-1), epinephrine, norepinephrine, lactate, arterial ketone body ratio, urine volume, blood urea nitrogen, creatinine, renin activity, angiotensin-II, lactate dehydrogenase, plasma-free hemoglobin, tracheal intubation time, and respiratory index. The IL-8 at 0.5, 3, and 6 h after CPB, and ET-1 at 3, 6, 9, and 18 h after CPB were significantly lower in the pulsatile group. Both epinephrine and norepinephrine were significantly lower in the pulsatile group. The respiratory index was significantly higher in the pulsatile group. In the present study, inhibitory effects on cytokine activity, edema in pulmonary alveoli, and endothelial damage were shown in addition to the favorable effects on catecholamine level, renal function, and peripheral circulation that have already been documented.
authors.affiliation: Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan. asezai@med.nihon-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Sezai
authors.forename: Motomi
authors.initials: M
authors.lastname: Shiono
authors.forename: Kin-ichi
authors.initials: K
authors.lastname: Nakata
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Hata
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Iida
authors.forename: Akira
authors.initials: A
authors.lastname: Saito
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hattori
authors.forename: Shinji
authors.initials: S
authors.lastname: Wakui
authors.forename: Masao
authors.initials: M
authors.lastname: Soeda
authors.forename: Makoto
authors.initials: M
authors.lastname: Taoka
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Umeda
authors.forename: Nanao
authors.initials: N
authors.lastname: Negishi
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Sezai
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002395:Catecholamines / Q000032:analysis; D001026:Coronary Artery Bypass / Q000379:methods*; D016207:Cytokines / Q000032:analysis / Q000276:immunology; D019332:Endothelin-1 / Q000032:analysis* / Q000276:immunology; D005260:Female; D006461:Hemolysis; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis* / Q000276:immunology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010477:Perfusion / Q000379:methods*; D011673:Pulsatile Flow / Q000276:immunology; D012129:Respiratory Function Tests
chemical_list: D002395:Catecholamines; D016207:Cytokines; D019332:Endothelin-1; D016209:Interleukin-8