Environment makes amphetamine-induced dopamine release in the nucleus accumbens totally impulse-dependent.
Environmental condition such as food restriction has been shown to produce sensitization to the stimulant and rewarding effects of amphetamine in the low responsive DBA/2J genotype. Here, we report that food-restricted DBA/2J mice lose the impulse-independent component of psychostimulant-induced dopamine release in the nucleus accumbens that is replaced totally by impulse-dependent dopamine release. These results indicate for the first time that the crucial effect of environment-induced sensitization is a dramatic increase of the impulse dependent component.
Ventura
Rossella
R
Dipartimento di Psicologia, Università "La Sapienza," and Fondazione Santa Lucia IRCCS, Rome, Italy. rossella.ventura@uniroma1.it
Puglisi-Allegra
Stefano
S
D000661:Amphetamine / Q000494:pharmacology*; D019969:Amphetamine-Related Disorders / Q000235:genetics / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004777:Environment; D045604:Extracellular Fluid / Q000378:metabolism; D005508:Food Deprivation / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D007175:Impulsive Behavior / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D012201:Reward; D026941:Sodium Channel Blockers / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D018765:Dopamine Uptake Inhibitors; D026941:Sodium Channel Blockers; D000661:Amphetamine; D004298:Dopamine