title: The structure-function correlates of mammalian rod and cone photoreceptor mitochondria: observations and unanswered questions.
abstract: Our previous work suggests that cone photoreceptor inner segment (CIS) mitochondria demand and produce more ATP than rods. The CISs utilize two complimentary strategies to increase ATP production: increase the absolute number of mitochondria and their cristae surface membrane area. In this treatise, we ask: How are crista junctions formed and regulated? Once formed, are there physical mechanisms that constrain their diameter? How are the constrictions in cristae regulated and is this key for cytochrome c release during apoptosis? What are their differences in rod and cone susceptibility to apoptotic cell death during calcium overload and oxidative stress?
authors.affiliation: Department of Neurosciences, University of California San Diego, La Jolla, CA 92093-0608, USA.
authors.forename: Guy A
authors.initials: GA
authors.lastname: Perkins
authors.forename: Mark H
authors.initials: MH
authors.lastname: Ellisman
authors.forename: Donald A
authors.initials: DA
authors.lastname: Fox