title: Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection.
abstract: Since the initial report of unusual manifestations possibly associated with chronic active Epstein-Barr virus (EBV) infection (CAEBV), nearly three decades have passed. During this period, reported cases with this entity have dramatically increased in the world. Additionally, recent development of diagnostic procedures, including molecular biological and immunological techniques, have provided us with the ability to define certain diseases, especially malignant disorders. Guidelines, derived mainly from the current literature and recent experiences with CAEBV in Japan, for diagnosing CAEBV are proposed to clarify this enigmatic disease.
authors.affiliation: Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan. okano_m@iph.pref.hokkaido.jp
authors.forename: Motohiko
authors.initials: M
authors.lastname: Okano
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Wakiguchi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Maeda
authors.forename: Shosuke
authors.initials: S
authors.lastname: Imai
authors.forename: Shouichi
authors.initials: S
authors.lastname: Ohga
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kanegane
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.forename: Masaaki
authors.initials: M
authors.lastname: Mori
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yokota
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Imashuku
mesh_terms: D000208:Acute Disease; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008967:Molecular Biology