title: Molecular recognition of nucleic acids: coralyne binds strongly to poly(A).
abstract: The small molecule coralyne was found to bind preferentially and strongly to single-stranded poly(A) with an apparent association constant (Ka) of (1.8+/-0.3) x 10(6)M(-1). Binding of coralyne to poly(A) is predominantly enthalpically driven with a stoichiometry of one coralyne per four adenine bases. Poly(A) forms a coralyne dependent secondary structure with a melting temperature of 60 degrees C, for the conditions of our study.
authors.affiliation: Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Xing
authors.forename: Guangtao
authors.initials: G
authors.lastname: Song
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Chaires
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000241:Adenosine / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001600:Berberine Alkaloids / Q000378:metabolism*; D002942:Circular Dichroism; D046911:Macromolecular Substances; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D001600:Berberine Alkaloids; D046911:Macromolecular Substances; D011108:Polymers; D012333:RNA, Messenger; C069424:polyadenosine; C000666:coralyne; D000241:Adenosine