title: A new interface to couple thin-layer chromatography with laser desorption/atmospheric pressure chemical ionization mass spectrometry for plate scanning.
abstract: An interface to allow on-line qualitative and quantitative full-plate detection and analysis of compounds separated by thin-layer chromatography (TLC) is presented. A continuous wave diode laser is employed as a desorption source. Atmospheric pressure chemical ionization mass spectrometry ionizes and subsequently identifies the desorbed sample molecules. Besides direct laser desorption on untreated TLC plates, graphite particles were used as a matrix to couple in the laser power and improve the efficiency of desorption.
authors.affiliation: Institute for Analytical Sciences, Bunsen-Kirchhoff-Strasse 11, 44139 Dortmund, Germany.
authors.forename: Song
authors.initials: S
authors.lastname: Peng
authors.forename: Michael
authors.initials: M
authors.lastname: Edler
authors.forename: Norman
authors.initials: N
authors.lastname: Ahlmann
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hoffmann
authors.forename: Joachim
authors.initials: J
authors.lastname: Franzke
mesh_terms: D001274:Atmospheric Pressure; D002845:Chromatography / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D013048:Specimen Handling / Q000295:instrumentation* / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation* / Q000379:methods*; D018511:Systems Integration