A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.
Gunn-Moore
Frank J
FJ
Schools of Biology and Medicine, University of St. Andrews, KY16 9TS, UK. fjg1@st-and.ac.uk
Welsh
Gavin I
GI
Herron
Lissa R
LR
Brannigan
Frances
F
Venkateswarlu
Kanamarlapudi
K
Gillespie
Stewart
S
Brandwein-Gensler
Margaret
M
Madan
Rashna
R
Tavaré
Jeremy M
JM
Brophy
Peter J
PJ
Prystowsky
Michael B
MB
Guild
Simon
S
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010743:Phospholipids / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D000099149:Ezrin
D048868:Adaptor Proteins, Signal Transducing; D001798:Blood Proteins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010743:Phospholipids; D010750:Phosphoproteins; D011993:Recombinant Fusion Proteins; D000099149:Ezrin; C504793:FRMD6 protein, human; C071058:moesin; C071776:radixin