title: Quantitative analysis of the corpus callosum in children with cerebral palsy and developmental delay: correlation with cerebral white matter volume.
abstract: BACKGROUND
  The direct quantitative correlation between thickness of the corpus callosum and volume of cerebral white matter in children with cerebral palsy and developmental delay has not been demonstrated.
  
  
  OBJECTIVE
  This study was conducted to quantitatively correlate the thickness of the corpus callosum with the volume of cerebral white matter in children with cerebral palsy and developmental delay.
  
  
  METHODS
  A clinical database of 70 children with cerebral palsy and developmental delay was established with children between the ages of 1 and 5 years. These children also demonstrated abnormal periventricular T2 hyperintensities associated with and without ventriculomegaly. Mid-sagittal T1-weighted images were used to measure the thickness (genu, mid-body, and splenium) and length of the corpus callosum. Volumes of interest were digitized based on gray-scale densities to define the hemispheric cerebral white matter on axial T2-weighted and FLAIR images. The thickness of the mid-body of the corpus callosum was correlated with cerebral white matter volume. Subgroup analysis was also performed to examine the relationship of this correlation with both gestational age and neuromotor outcome. Statistical analysis was performed using analysis of variance and Pearson correlation coefficients.
  
  
  RESULTS
  There was a positive correlation between the thickness of the mid-body of the corpus callosum and the volume of cerebral white matter across all children studied (R=0.665, P=0.0001). This correlation was not dependent on gestational age. The thickness of the mid-body of the corpus callosum was decreased in the spastic diplegia group compared to the two other groups (hypotonia and developmental delay only; P<0.0001). Within each neuromotor subgroup, there was a positive correlation between thickness of the mid-body of the corpus callosum and volume of the cerebral white matter.
  
  
  CONCLUSIONS
  The thickness of the mid-body of the corpus callosum positively correlates with volume of cerebral white matter in children with cerebral palsy and developmental delay, regardless of gestational age or neuromotor outcome. Assessment of the thickness of the corpus callosum might help in estimating the extent of the loss of volume of cerebral white matter in children with a broad spectrum of periventricular white matter injury.
authors.affiliation: Department of Radiology, Childrens Hospital Los Angeles, 4650 Sunset Blvd., Mail Stop 81, Los Angeles, CA, USA. apanigrahy@chla.usc.edu
authors.forename: Ashok
authors.initials: A
authors.lastname: Panigrahy
authors.forename: Patrick D
authors.initials: PD
authors.lastname: Barnes
authors.forename: Robert L
authors.initials: RL
authors.lastname: Robertson
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Sleeper
authors.forename: James W
authors.initials: JW
authors.lastname: Sayre
mesh_terms: D061085:Agenesis of Corpus Callosum; D000704:Analysis of Variance; D001921:Brain / Q000002:abnormalities*; D002547:Cerebral Palsy / Q000473:pathology* / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000002:abnormalities; D002560:Cerebrovascular Circulation; D002675:Child, Preschool; D003337:Corpus Callosum / Q000503:physiopathology; D002658:Developmental Disabilities / Q000473:pathology* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007089:Image Enhancement; D007223:Infant; D008279:Magnetic Resonance Imaging; D009123:Muscle Hypotonia / Q000473:pathology / Q000503:physiopathology; D012107:Research Design; D012189:Retrospective Studies