title: [Study on the stability of tetrandrine microsphere].
abstract: OBJECTIVE
  To study the stability of Tetrandrine Microsphere.
  
  
  METHODS
  Higher speed test and room temperature test were adopted to investigate the indexes, such as properties of appearance, amount of medicine loaded, seal rate, seepage rate, microbial stability, etc.
  
  
  RESULTS
  Through the test of six months, properties of appearance, amount of medicine loaded, seal rate, seepage rate, microbial stability have not obviously change. But after testing for 6 months with higher temperature, the seal rate was reduced, and the seepage rate was increased.
  
  
  CONCLUSIONS
  Tetrandrine microsphere is steady under the room temperature condition, but is unstable to hot, and ought to keep in conformity with low-temperature.
authors.affiliation: Nanfang Medical University, Guangzhou.
authors.forename: Guohu
authors.initials: G
authors.lastname: Cheng
authors.forename: Jiabo
authors.initials: J
authors.lastname: Luo
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000302:isolation & purification; D044182:Benzylisoquinolines / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004304:Dosage Forms; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D029583:Menispermaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
chemical_list: D000470:Alkaloids; D044182:Benzylisoquinolines; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; C009438:tetrandrine