Regulatory effects of cytokine production in atopic allergic reaction by gammi-danguieumja.
Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. In addition, GD inhibited histamine release from activated mast cells. These results suggest that GD contributes to the regulation of atopic allergic reactions.
Na
Ho-Jeong
HJ
College of Oriental Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul, South Korea.
Shin
Hye-Young
HY
Kim
Na-Hyung
NH
Kwon
Mi-Won
MW
Park
Eun-Jeong
EJ
Hong
Seung-Heon
SH
Kim
Nam-Il
NI
Kim
Hyung-Min
HM
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology* / Q000633:toxicity; D000001:Calcimycin; D002460:Cell Line; D002470:Cell Survival; D016207:Cytokines / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D007476:Ionophores; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D003189:p-Methoxy-N-methylphenethylamine
D018926:Anti-Allergic Agents; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; D007476:Ionophores; D014409:Tumor Necrosis Factor-alpha; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; C016658:phorbolol myristate acetate; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate