title: Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis.
abstract: OBJECTIVE
  To explore the relationship between differential leucocyte count and coronary atherosclerosis.
  
  
  METHODS
  The study population consisted of 507 consecutive patients (376 male and 131 female) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' smoking and drinking habits were investigated, and anthropometric measurements, serum measurements, and hematological measurements were conducted for every patient. The severity of coronary atherosclerosis was defined by using Gensini's score system. One-way ANOVA, Spearman's correlation analysis, and multivariate stepwise linear regression analysis were employed to explore the relationship between differential leucocyte count and coronary atherosclerosis.
  
  
  RESULTS
  One-way ANOVA indicated that the diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and platelet count differed among the groups according to Gensini's score, the tertile values of which were used as cutoff points. Spearman's correlation analysis suggested that Gensini's score was significantly correlated with age, diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and erythrocyte count, respectively. Multivariate stepwise linear regression analysis show that neutrophil count (beta=0.247, P=0.000), age (beta=0.141, P=0.001), glucose (beta=0.173, P=0.000), creatinine (beta=0.088, P=0.063), hemoglobin (beta=-0.168, P=0.013) and sex (men were coded as 1 and women were coded as 2; beta=-0.121, P=0.012) were significantly independently associated with the Gensini's score.
  
  
  CONCLUSIONS
  The independent association of neutrophil count with the angiographical characteristics of coronary atherosclerosis, as estimated by Gensini's score, strongly suggests that granulocytosis may play a role in the development of coronary atherosclerosis.
authors.affiliation: Department of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. enzhijia@yahoo.com.cn
authors.forename: En-zhi
authors.initials: EZ
authors.lastname: Jia
authors.forename: Zhi-jian
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Biao
authors.initials: B
authors.lastname: Yuan
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Zang
authors.forename: Rong-hu
authors.initials: RH
authors.lastname: Wang
authors.forename: Tie-bing
authors.initials: TB
authors.lastname: Zhu
authors.forename: Lian-sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Wen-zhu
authors.initials: WZ
authors.lastname: Ma
mesh_terms: D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003404:Creatinine / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000473:pathology*; D012720:Severity of Illness Index; D012737:Sex Factors; D012907:Smoking
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D003404:Creatinine