Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice.
Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.
El Yacoubi
Malika
M
FRE 2735 CNRS, IFRMP 23, UFR de Médecine and Pharmacie, Rouen Cedex1, France.
Ledent
Catherine
C
Parmentier
Marc
M
Costentin
Jean
J
Vaugeois
Jean-Marie
JM
D058917:Adenosine A2 Receptor Antagonists; D000818:Animals; D001066:Appetite / Q000187:drug effects* / Q000502:physiology; D002110:Caffeine / Q000008:administration & dosage*; D004326:Drinking / Q000187:drug effects; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D043705:Receptor, Adenosine A2A / Q000235:genetics / Q000502:physiology*
D058917:Adenosine A2 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D002110:Caffeine