Sustained CD8+ T-cell responses induced after acute parvovirus B19 infection in humans.
Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8+ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.
Norbeck
Oscar
O
Infectious Diseases Unit, Center of Molecular Medicine, Karolinska Institutet, Karolinska University Hospital L08:03, SE-17177 Stockholm, Sweden. oscar.norbeck@cmm.ki.se
Isa
Adiba
A
Pöhlmann
Christoph
C
Broliden
Kristina
K
Kasprowicz
Victoria
V
Bowness
Paul
P
Klenerman
Paul
P
Tolfvenstam
Thomas
T
D000208:Acute Disease; D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D036022:Capsid Proteins / Q000235:genetics / Q000276:immunology; D000939:Epitopes / Q000235:genetics; D005260:Female; D006801:Humans; D051379:Mice; D008875:Middle Aged; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D011446:Prospective Studies; D013997:Time Factors; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000276:immunology
D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; D017361:Viral Nonstructural Proteins; C095548:capsid protein VP2, parvovirus B19