Enantioselective C-C bond synthesis catalysed by enzymes.
The enantioselective synthesis of C-C bonds is often the pivotal step of a synthesis. Nature has made a variety of versatile enzymes available that catalyse this type of reaction very selectively under mild conditions. Cyanohydrins, acyloins (alpha-hydroxy ketones), alpha-hydroxy acids and aldols (beta-hydroxy ketones) are very efficiently synthesised enantioselectively with the aid of C-C bond forming enzymes, which we discuss in this tutorial review. In the case of the alpha-hydroxy acids the applications of nitrilases in a synthetic dkr even allows a disconnection that has no enantioselective chemical equivalent.
Sukumaran
Joly
J
Gebouw voor Scheikunde, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands.
Hanefeld
Ulf
U
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry*; D005233:Fatty Alcohols / Q000737:chemistry; D006836:Hydro-Lyases / Q000737:chemistry; D006880:Hydroxy Acids / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
D004798:Enzymes; D005233:Fatty Alcohols; D006880:Hydroxy Acids; D009570:Nitriles; C430593:cyanohydrin; C011159:acyloin; D002244:Carbon; D006836:Hydro-Lyases