[Phosphate transport and kidney stones].
Our understanding of phosphate homeostasis and of its abnormalities has improved substantially during the last decade thanks to major advances in two areas: on the one hand, molecular identification of sodium-phosphate cotransport systems belonging to three major families and, on the other hand, discovery of regulatory factors, consisting of either intracellular proteins which interact with these cotransporters, or circulating peptides. Phenotypic analysis of genetically modified mice and of human disorders has shed light on the key role of the phosphate balance in kidney stone formation.
Friedlander
Gérard
G
Université Paris-Descartes, Faculté de Médecine, INSERM, AP-HP Hôpital Necker-EnfantsMalades, U 426, 149 rue de Sèvres, 75015 Paris.
D000818:Animals; D001692:Biological Transport; D006706:Homeostasis; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism; D007669:Kidney Calculi / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates