title: Normal brain tissue volumes after long-term recovery in anorexia and bulimia nervosa.
abstract: BACKGROUND
  Individuals who are ill with anorexia (AN) and bulimia nervosa (BN) often have increased cerebrospinal fluid (CSF) volumes and decreased total gray and white matter volumes. It is unclear whether such disturbances persist after recovery from an eating disorder.
  
  
  METHODS
  Magnetic resonance imaging was performed on 40 women who were long-term recovered (>1 year no binging, purging, or restricting behaviors, normal weight, and menstrual cycles, not on medication) from restricting or binge/purging type AN or BN and 31 healthy control women (CW). Voxel-based morphometry (VBM) was used for data analysis.
  
  
  RESULTS
  Recovered AN and BN subgroups were similar to CW in terms of cerebrospinal fluid (CSF) volume as well as total or regional gray or white matter volume.
  
  
  CONCLUSIONS
  These findings suggest that structural brain abnormalities are reversible in individuals with eating disorders after long-term recovery.
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Wagner
authors.forename: Phil
authors.initials: P
authors.lastname: Greer
authors.forename: Ursula F
authors.initials: UF
authors.lastname: Bailer
authors.forename: Guido K
authors.initials: GK
authors.lastname: Frank
authors.forename: Shannan E
authors.initials: SE
authors.lastname: Henry
authors.forename: Karen
authors.initials: K
authors.lastname: Putnam
authors.forename: Carolyn C
authors.initials: CC
authors.lastname: Meltzer
authors.forename: Scott K
authors.initials: SK
authors.lastname: Ziolko
authors.forename: Jessica
authors.initials: J
authors.lastname: Hoge
authors.forename: Claire
authors.initials: C
authors.lastname: McConaha
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000473:pathology* / Q000534:rehabilitation; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002032:Bulimia / Q000473:pathology* / Q000534:rehabilitation*; D002552:Cerebral Ventricles / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D020127:Recovery of Function / Q000502:physiology