[Changes of plasma CD62p levels in patients with acute cerebral infarction].
OBJECTIVE
To explore the function of CD62p in cerebral infarction and the relation between the changes of its level and the severity and recovery of cerebral infarction, MPV, PDW and PLT by studying the changes of the levels of plasma CD62p in patients with acute cerebral infarction.


METHODS
The levels of plasma CD62p were measured by ELISA in 60 patients at 48 hours, 6 - 8 days and 15 days after ischemia, and at the same time, we evaluated neurological function deficiency score and measured MPV, PDW and PLT. The levels of 30 healthy persons mating cerebral infarction group in both sex and ages were measured.


RESULTS
The levels of plasma CD62p in the patients with acute cerebral infarction were obviously higher than the levels of the healthy controls (P < 0.001). The levels of plasma CD62 p in CI group at 48 hours postischemia were higher than the levels at 6 - 8 days and at 15 days with obvious difference (P <0.01). The levels of plasma CD62p in the medium and the severe SSS patients were higher than the levels of the lights (P <0.001). The levels of plasma CD62p were positively correlated with SSS, MPV and PDW (r = 0.61, 0.51, 0.47, P < 0.01), and negatively correlated with PLT (r = -0.32, P < 0.01).


CONCLUSIONS
CD62p may participate in acute cerebral infarction and play a crucial role, and the change of its levels correlates with SSS, MPV, PDW and Plt.
Huang
Xiao-Song
XS
Department of Neurology,Xiangya Hospital, Central South University, Changsha. Huangxs-0819@163.com
Yang
Qi-Dong
QD
Liu
Yun-Hai
YH
Liu
Zun-Jing
ZJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011379:Prognosis
D019007:P-Selectin