title: Efficacy of moxidectin 0.5% pour-on against naturally acquired nematode infections in cattle in the Mexican tropics.
abstract: The efficacy of 0.5% moxidectin pour-on in cows with naturally acquired nematode infections was evaluated. The study was carried out in a ranch in Veracruz, Mexico. Four groups of 15 cows were randomly allocated. Animals in the treated group received 0.5% moxidectin pour-on at a dose of 0.5 mg/kg body weight on a single occasion. The other two groups remained as untreated controls. Fecal samples from all cattle were taken on days 0 (pre-treatment), 7, 14, 28 and 60 (post-treatment, PT). Fecal egg-counts were determined using a modified McMaster technique and fecal cultures were performed to identify gastrointestinal nematodes infected larvae (L(3)). Treatment with moxidectin was associated with a significant reduction in fecal trichostrongyle egg-counts compared with the controls; efficacy was 100% at 28 days PT. Haemonchus spp. and Strongyloides spp. were the two genera identified from coprocultures.
authors.affiliation: Centro de Enseñanza Investigación y Extensión en Ganadería Tropical, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Veracruz, Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Maritorena-Diez
authors.forename: S
authors.initials: S
authors.lastname: Roa-Vásquez
authors.forename: B
authors.initials: B
authors.lastname: Marín-Mejía
authors.forename: M A
authors.initials: MA
authors.lastname: Alonso-Díaz
authors.forename: R I
authors.initials: RI
authors.lastname: Rodríguez-Vivas
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D018942:Macrolides / Q000008:administration & dosage; D008800:Mexico; D009348:Nematoda / Q000254:growth & development*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D018709:Statistics, Nonparametric; D014329:Tropical Climate
chemical_list: D000969:Antinematodal Agents; D018942:Macrolides; C027837:moxidectin