title: Effect of Helicobacter pylori infection on gastric mucosal pathologic change and level of nitric oxide and nitric oxide synthase.
abstract: OBJECTIVE
  To investigate the level of nitric oxide (NO) and nitrous oxide synthase (NOS) enzyme and its effect on gastric mucosal pathologic change in patients infected with Helicobacter pylori (H pylori), and to study the pathogenic mechanism of H pylori.
  
  
  METHODS
  The mucosal tissues of gastric antrum were taken by endoscopy, then their pathology, H pylori and anti-CagA-IgG were determined. Fifty H pylori positive cases and 35 H pylori negative cases were randomly chosen. Serum level of NO and NOS was detected.
  
  
  RESULTS
  One hundred and seven cases (71.33%) were anti-CagA-IgG positive in 150 H pylori positive cases. The positive rate was higher especially in those with pre-neoplastic diseases, such as atrophy, intestinal metaplasia and dysplasia. The level of NO and NOS in positive group was higher than that in negative group, and apparently lower in active gastritis than in pre-neoplastic diseases such as atrophy, intestinal metaplasia and dysplasia.
  
  
  CONCLUSIONS
  H pylori is closely related with chronic gastric diseases, and type I H pylori may be the real factor for H pylori-related gastric diseases. Infection with H pylori can induce elevation of NOS, which produces NO.
authors.affiliation: First Hospital, Baotou Medical College, University of Science and Technology of Inner Mongolia, Baotou 014010, Inner Mongolia, China. wyf5168@hotmail.com
authors.forename: Yong-Fu
authors.initials: YF
authors.lastname: Wang
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Guo
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Zhao
authors.forename: Guo-An
authors.initials: GA
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Hong-Kun
authors.initials: HK
authors.lastname: Wang
mesh_terms: D002908:Chronic Disease; D005753:Gastric Mucosa / Q000201:enzymology / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000378:metabolism* / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000201:enzymology / Q000473:pathology
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase