title: [Effects of the Panax notoginseng saponins on the level of synaptophysin protein in brain in rat model with lesion of Meynert].
abstract: OBJECTIVE
  To observe the protective effect of Panax notoginseng saponins (PNS) on the level of synaptophysin ptotein in brain in rat model with Alzheimer's disease (AD).
  
  
  METHODS
  The AD rat models were established by intra-peritoneal injection of D-galactose combined with excitatory neurotoxin ibotenic acid injection into bilateral nbM. The activity and content of synaptophysin protein in brain were determined by immunohistochemistry analysis.
  
  
  RESULTS
  PNS could reduce the lesion of level of synaptophysin protein in brain, as compared with those of model group's rats.
  
  
  CONCLUSIONS
  PNS plays a protective role by reducing down of the level of synaptophysin protein in brain in lesion of AD animal model.
authors.affiliation: Istitute of Neurosciece Research, Gangxi Traditional Chinese Medical Nanning 530001, China. zhongzg@gxtcmu.edu.cn
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zhong
authors.forename: Ze-Qiang
authors.initials: ZQ
authors.lastname: Qu
authors.forename: Nai-Ping
authors.initials: NP
authors.lastname: Wang
authors.forename: Feng-Fen
authors.initials: FF
authors.lastname: Zhang
authors.forename: Wen-Yan
authors.initials: WY
authors.lastname: Zhang
authors.forename: Uzhong-Peng
authors.initials: UP
authors.lastname: Lu
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D020532:Basal Nucleus of Meynert / Q000187:drug effects / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005690:Galactose / Q000633:toxicity; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000633:toxicity; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D016708:Synaptophysin / Q000378:metabolism*
chemical_list: D036145:Ginsenosides; D018696:Neuroprotective Agents; D016708:Synaptophysin; D007051:Ibotenic Acid; D005690:Galactose