title: Photo-infrared pulsed bio-modulation (PIPBM): a novel mechanism for the enhancement of physiologically reparative responses.
abstract: OBJECTIVE
  The present manuscript describes the non-invasive, long-range, energy transport of a singular infrared pulsed laser device (IPLD) and the upstream components of the original action mechanism, designated photo-infrared pulsed bio-modulation (PIPBM).
  
  
  BACKGROUND
  Major strides have been taken in recent years towards scientifically acceptable clinical applications of low-energy lasers. Nevertheless, challenges still abound. For instance, the range of potential target tissues for laser therapy in medicine has been, until now, limited by the optical penetration of the beam or to sites accessible by fiberoptics. In addition, much needs to be learned about the action mechanisms of pulsed lasers, which can induce unique biological effects.
  
  
  METHODS
  We present a review of the IPLD laser technology and the PIPBM mechanism.
  
  
  RESULTS
  The studies reviewed suggest that the PIPBM enhances physiologically reparative processes in a non-toxic and selective manner through the activation and modulation of chaotic dynamics in water. These, in turn, lead not only to local, but also long-distance (systemic) effects.
  
  
  CONCLUSIONS
  Though additional studies are necessary to fully explore the biological effects of the PIPBM induced by the IPLD, this mechanism may have multiple potential applications in medicine that are the subject of active current and future investigations.
authors.affiliation: Fundalas, Foundation for Interdisciplinary Research and Development, Caracas, Venezuela. fundalas@mail2science.com
authors.forename: Luis A
authors.initials: LA
authors.lastname: Santana-Blank
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rodríguez-Santana
authors.forename: Karin E
authors.initials: KE
authors.lastname: Santana-Rodríguez
mesh_terms: D000255:Adenosine Triphosphate / Q000528:radiation effects*; D055592:Biophysical Phenomena; D001703:Biophysics; D002477:Cells / Q000528:radiation effects*; D004735:Energy Transfer / Q000528:radiation effects*; D006801:Humans; D007259:Infrared Rays / Q000627:therapeutic use; D028022:Low-Level Light Therapy / Q000379:methods*; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D000255:Adenosine Triphosphate