[Recent pharmacological study on sanshengwan decoction].
OBJECTIVE
To investigate the pharmacological function of Sanshengwan decoction with modern medical and rheological techniques, and also to discuss the differences between injury blood stasis syndrome and yang deficiency blood stasis syndrome.


METHODS
Animal model for injury blood stasis syndrome was found by bruise; Animal model for yang deficiency blood stasis syndrome was done by exhausting the animals in a - 15 degrees C freezer for 4 hours.


RESULTS
Blood fibrinogen content, platelet aggregation and blood coagulation time were significantly increased, plasma viscosity and blood coagulation slope was significantly decreased in injury blood stasis syndrome group. Blood fibrinogen content, platelet aggregation and blood coagulation time were dropped markedly. Blood coagulation slope was raised noticeably in yang deficiency blood stasis syndrome group. Sanshengwan decoction behaved very good effects on removing blood stasis on both of the two kinds of animal models.


CONCLUSIONS
Though hemorheological index and experimental data in the two kinds of animal models were behaved statistically significance, but the experimental representative indexes were obviously difference. Sanshengwan the tipical herbal medicine for eliminating blood stasis syndrome showed significantly effects on both of the two kinds of animal models, but the effects on injury blood stasis syndrome group was better than the other animal model's.
Wen
Rui-Xing
RX
Life sciences and biomedical engineering college, Beijing University of polytechniques, Beijing 100022, China. rxwen@bjut.edu.cn
Li
Wen
W
Li
Yun
Y
Cui
Cheng-De
CD
Yin
Xiao-Jie
XJ
Liao
Fu-Long
FL
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism; D018056:Hemorheology; D008297:Male; D008516:Medicine, Chinese Traditional; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014947:Wounds and Injuries / Q000097:blood*; D016711:Yang Deficiency / Q000097:blood*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005340:Fibrinogen