title: Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats.
abstract: We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.
authors.affiliation: Eye Clinic, Svjetlost, Zagreb, Croatia. ratimir.lazic@zg.htnet.hr
authors.forename: Ratimir
authors.initials: R
authors.lastname: Lazić
authors.forename: Nikica
authors.initials: N
authors.lastname: Gabrić
authors.forename: Iva
authors.initials: I
authors.lastname: Dekaris
authors.forename: Damir
authors.initials: D
authors.lastname: Bosnar
authors.forename: Alenka
authors.initials: A
authors.lastname: Boban-Blagaić
authors.forename: Predrag
authors.initials: P
authors.lastname: Sikirić
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000662:veterinary; D004848:Epithelium; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157