title: [Effect of ulinastatin on human blood coagulation and platelet aggregation in orthopaedic surgery].
abstract: OBJECTIVE
  To investigate the effect of ulinastatin (UTI) on human blood coagulation and platelet aggregation in orthopaedic surgery.
  
  
  METHODS
  Thirty ASA I-II patients without blood dyscrasia and blood coagulation obstacle were randomly divided into two groups: Group I (UTI group, n=15) in which patients received UTI 5000 U/kg, and Group II (control group, n=15) in which patients received NS 100 ml. PT, TT, APTT, IB, INR and PAG1, PAG5, and PAGM were measured at 3 points: pre-infusion (T0), 1 hour after the infusion (T1), and 2 hours after the infusion (T2).
  
  
  RESULTS
  Compared with the saline group, APTT and PT of UTI group were prolonged significantly than the baseline (before infusion). In Group I, after the infusion, APT, TT and PT were prolonged significantly than before the infusion.
  
  
  CONCLUSIONS
  UTI 5000 U/kg can ameliorate orthopaedic patients and blood coagulation status,which may reduce microthrombus syndrome in the operation and prevent venous thrombosis after the operation.
authors.affiliation: Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. zwyfeng@163.com
authors.forename: Wang-yuan
authors.initials: WY
authors.lastname: Zou
authors.forename: Qu-lian
authors.initials: QL
authors.lastname: Guo
authors.forename: Jin
authors.initials: J
authors.lastname: Cai
authors.forename: He-guo
authors.initials: HG
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011183:Postoperative Complications / Q000517:prevention & control; D014361:Trypsin Inhibitors / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000517:prevention & control*
chemical_list: D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin