Esthesioneuroblastoma metastatic to the breast in a young woman.
BACKGROUND
Metastases to the breast are rare and can be missed without knowledge of the clinical history. We report an unusual breast metastasis originating in an olfactory neuroblastoma.


METHODS
A breast metastasis from esthesioneuroblastoma occurred in a 20-year-old woman 2 years after the onset of the disease. The aspirates were hypercellular and composed of cellular aggregates and single cells with a monomorphic appearance. The cytoplasm was scanty and inconspicuous. The nucleus was large, with granular, hyperchromatic chromatin. Mitoses and apoptotic bodies were numerous. Because we were unaware of the past history at the time of the cytologic analysis, a definitive diagnosis was made only after pathologic study.


CONCLUSIONS
Esthesioneuroblastoma metastatic to the breast must be considered in the differential diagnosis of breast metastases. Fine needle aspiration, in conjunction with clinical information, can be effective in the diagnosis of esthesioneuroblastoma metastatic to the breast.
Mrad
Karima
K
Department of Pathology, Salah Azaiez Institute, 1006 Bab Saadoun, Tunis, Tunisia. karima.mrad@rns.tn
Mansouri
Dhouha
D
Driss
Maha
M
Sassi
Samia
S
Abbes
Imene
I
Ben Ayed
Farhat
F
Ben Romdhane
Khaled
K
D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009296:Nasal Cavity / Q000473:pathology*; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology