Effect of N-benzoyl-D-phenylalanine, a new potential oral antidiabetic agent, in neonatal streptozotocin-induced diabetes in rats.
The present investigation was undertaken to study the effect of treatment with D-phenylalanine derivative and metformin in neonatal streptozotocin (nSTZ)-induced non-insulin-dependent diabetes mellitus (NIDDM) in rats. To induce NIDDM, a single dose injection of streptozotozin (STZ) (100 mg kg(-1); ip) was given to 2-day-old rats. After 10-12 weeks, rats weighing above 150 g were selected for screening in NIDDM model. They were checked for fasting blood glucose levels to conform the status of NIDDM. D-phenylalanine derivative (50, 100 and 200 mg kg(-1)) was administered per os (po) for 6 weeks to the rats with confirmed diabetes. A group of diabetic rats was also maintained and this group received metformin as comparative drug. Significant decrease in blood glucose with significant increase in plasma insulin was observed in group receiving 100 mg of D-phenylalanine derivative plus 500 mg of metformin.
Pari
Leelavinothan
L
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu - 608 002, India. paribala@sancharnet.in
Ashokkumar
Natarajan
N
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010649:Phenylalanine; D013311:Streptozocin; D008687:Metformin; C053764:benzoylphenylalanine