title: Pyogranuloma caused by Mycobacterium asiaticum infection in a steer.
abstract: In 2003, a steer carcass was condemned at a Central Queensland abattoir because of metastatic tumors. In addition, a granulomatous lesion was found in the mediastinal lymph node. Histological examination showed this to be a pyogranuloma, typically associated with Rhodococcus or the Nocardia/Streptomyces group. However, in this case, the only etiological agent was an acid-fast bacillus, which would normally be associated with a more fibrous lesion. A number of nucleic acid-based techniques were used, and the isolate was identified as Mycobacterium asiaticum. This organism is a rarely encountered opportunistic pathogen of humans, associated with subtropical climates. This is the first report of this organism causing infection in cattle. The similarities between this case and cases of human disease are discussed.
authors.affiliation: Oonoonba Veterinary Laboratory, Department of Primary Industries and Fisheries, Biosecurity North Region, PO Box 1085, Townsville, Queensland 4810, Australia.
authors.forename: Jane
authors.initials: J
authors.lastname: Oakey
authors.forename: Judy
authors.initials: J
authors.lastname: Forbes-Faulkner
authors.forename: Christopher
authors.initials: C
authors.lastname: Gilpin
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Murdoch
authors.forename: Steven
authors.initials: S
authors.lastname: Johnson
mesh_terms: D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D016384:Consensus Sequence; D004269:DNA, Bacterial / Q000032:analysis / Q000737:chemistry; D006099:Granuloma / Q000382:microbiology / Q000662:veterinary*; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008297:Male; D008482:Mediastinum; D008969:Molecular Sequence Data; D009161:Mycobacterium / Q000235:genetics / Q000302:isolation & purification*; D009164:Mycobacterium Infections / Q000382:microbiology / Q000662:veterinary*; D009894:Opportunistic Infections / Q000382:microbiology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015183:Restriction Mapping / Q000662:veterinary
chemical_list: D004269:DNA, Bacterial