"Determination of domperidone in tablet dosage form by anodic differential pulse voltammetry".
A differential pulse voltammetric method was described for the determination of domperidone. The method was based on the anodic oxidation of domperidone on a glassy carbon electrode at +0.64 V vs. SCE in Britton-Robinson buffer solution of pH 2.3. The reversibility of the oxidation was tested by cyclic voltammetry; the electrode process is irreversible and diffusion-adsorption controlled. Calibrations are linear over the range 1.0 x 10(-6)-2.0 x 10(-5) M of domperidone with a detection limit of 4.0 x 10(-7) M. The method was applied, without any interference from the excipients, to the determination of the drug in a tablet dosage form.
Wahdan
Tarek
T
Chemistry Department, Faculty of Education, Suez Canal University, 45111 Al-Arish, Egypt. tarekwahdan@yahoo.com
El-Ghany
Nadia Abd
NA
D000932:Antiemetics / Q000032:analysis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D004294:Domperidone / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013607:Tablets
D000932:Antiemetics; D013607:Tablets; D004294:Domperidone; D002244:Carbon