title: Similarities in the phenotype of the auditory neural substrate in children with Asperger syndrome and their parents.
abstract: Asperger syndrome (AS) is a developmental disorder of brain function characterized by deficits in social interaction including difficulties in understanding emotional expressions. Children with AS share some of the behavioural characteristics with their parents and AS seems to run particularly in the male members of the same families. The aim of the present study was to determine whether similarities could be found between children with AS and their parents at central auditory processing. It was found that in children with AS the sound encoding, as reflected by the exogenous components of event-related potentials, was similarly abnormal as in both their mothers and fathers. However, their abnormal cortical auditory discrimination, as indexed by the prolonged latency of the mismatch negativity, resembled that of their fathers but not that of their mothers. The present results suggest that complex genetic mechanisms may contribute to auditory abnormalities encountered in children with AS.
authors.affiliation: Cognitive Brain Research Unit, Department of Psychology, PO Box 9, 00014 University of Helsinki, Helsinki, Finland. eira.jansson-verkasalo@helsinki.fi
authors.forename: E
authors.initials: E
authors.lastname: Jansson-Verkasalo
authors.forename: T
authors.initials: T
authors.lastname: Kujala
authors.forename: K
authors.initials: K
authors.lastname: Jussila
authors.forename: M L
authors.initials: ML
authors.lastname: Mattila
authors.forename: I
authors.initials: I
authors.lastname: Moilanen
authors.forename: R
authors.initials: R
authors.lastname: Näätänen
authors.forename: K
authors.initials: K
authors.lastname: Suominen
authors.forename: P
authors.initials: P
authors.lastname: Korpilahti
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D020817:Asperger Syndrome / Q000503:physiopathology*; D001307:Auditory Perception / Q000502:physiology*; D002648:Child; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D010290:Parents; D010641:Phenotype; D011930:Reaction Time / Q000502:physiology