Isoprenylated naphthoquinone dimers firmianones A, B, and C from Firmiana platanifolia.
Three new compounds designated as firmianones A, B, and C (1-3), along with 13 known compounds, were isolated from the roots of Firmiana platanifolia. Their structures were elucidated by interpretation of HRESIMS, 1H-1H COSY, HMQC, HMBC, and NOESY. The absolute configurations of firmianones A and B with a rare hexacyclic skeleton were determined by CD exciton-coupling experiments. Firmianones A and B exhibited moderate cytotoxicity to the P388 cancer cell line.
Bai
Haiyun
H
National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, CAS, Shanghai, 201203, People's Republic of China.
Li
Shuo
S
Yin
Feng
F
Hu
Lihong
L
D000818:Animals; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D019660:Malvaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal; D009285:Naphthoquinones; C504106:firmianone A; C504107:firmianone B; C504108:firmianone C