title: Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.
abstract: Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Gary K
authors.initials: GK
authors.lastname: Beauchamp
authors.forename: Russell S J
authors.initials: RS
authors.lastname: Keast
authors.forename: Diane
authors.initials: D
authors.lastname: Morel
authors.forename: Jianming
authors.initials: J
authors.lastname: Lin
authors.forename: Jana
authors.initials: J
authors.lastname: Pika
authors.forename: Qiang
authors.initials: Q
authors.lastname: Han
authors.forename: Chi-Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
authors.forename: Paul A S
authors.initials: PA
authors.lastname: Breslin
mesh_terms: D000447:Aldehydes / Q000009:adverse effects / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000081004:Cyclopentane Monoterpenes; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects / Q000494:pharmacology; D007052:Ibuprofen / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D031658:Olea / Q000737:chemistry*; D000069463:Olive Oil; D010636:Phenols / Q000009:adverse effects / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D010938:Plant Oils / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D000081004:Cyclopentane Monoterpenes; D004042:Dietary Fats, Unsaturated; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; C503534:oleocanthal; D007052:Ibuprofen