Delayed effects of daphnia intoxication with selective and nonselective inhibitors of acetylcholinesterase.
Chronic experiments on successive generations of laboratory Daphnia magna culture demonstrated higher (compared to proserin) embryotoxicity of a new selective acetylcholinesterase inhibitor 1,3-bis[5-(diethyl-o-nitrobenzilammonio)pentyl]-6-methyluracyl dibromide (compound No. 547). The concentrations of proserin (neostigmine) and compound No. 547 not exceeding 1/60 LC50 (0.39 mol/liter for compound No. 547 and 0.045 mol/liter for proserin) were absolutely safe for the reproductive function of daphnia.
Zobov
V V
VV
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, Russia.
Berezinskii
L A
LA
Aslyamova
A A
AA
Reznik
V S
VS
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003621:Daphnia / Q000187:drug effects / Q000196:embryology; D004625:Embryo, Nonmammalian; D005260:Female; D005298:Fertility / Q000187:drug effects; D009388:Neostigmine / Q000633:toxicity*; D018675:Toxicity Tests; D014498:Uracil / Q000031:analogs & derivatives* / Q000633:toxicity
C461221:Agent No. 547; D002800:Cholinesterase Inhibitors; D009388:Neostigmine; D014498:Uracil