title: Complex character analysis of heart rate variability following brain asphyxia.
abstract: In the present study Renyi entropy and L-Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n=5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n=5) without medication. Renyi entropy and L-Z complexity of the R-R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.
authors.affiliation: Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Cai
authors.forename: Yihong
authors.initials: Y
authors.lastname: Qiu
authors.forename: Lan
authors.initials: L
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Sijun
authors.initials: S
authors.lastname: Hu
authors.forename: Peter R
authors.initials: PR
authors.lastname: Smith
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Crabtree
authors.forename: Shanbao
authors.initials: S
authors.lastname: Tong
authors.forename: Nitish V
authors.initials: NV
authors.lastname: Thakor
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D001237:Asphyxia / Q000150:complications*; D001921:Brain / Q000187:drug effects; D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004562:Electrocardiography / Q000379:methods*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: C402107:2-(phosphonomethyl)pentanedioic acid; D018696:Neuroprotective Agents; D009943:Organophosphorus Compounds