[Platelet associated immunoglobulin in the pathogenesis of thrombocytopenia in patients with chronic liver disease].
OBJECTIVE
To explore the role of platelet associated immunoglobulin (PAIg) in the mechanism of thrombocytopenia associated with chronic liver disease.


METHODS
The levels of PAIg, PAIgG, PAIgA, and PAIgM were detected in 48 viral hepatitis patients with thrombocytopenia, 36 viral hepatitis patients with normal platelet count and 20 healthy subjects by flow cytometry.


RESULTS
PAIg and PAIgG levels (34.54 +/- 14.54%, 28.98 +/- 14.77%, respectively) in the 48 viral hepatitis with thrombocytopenia were significantly higher than those [(21.12 +/- 10.88)%, (16.60 +/- 7.83)%, respectively, P < 0.001)] in the 36 viral hepatitis with normal platelet count and those [(21.15 +/- 16.15) %, (14.89 +/- 9.57)% , respectively, P < 0.01)] in the 20 healthy controls. An inverse correlation was found between the platelet count and PAIg levels (r = -0.446, P < 0.01), and an inverse correlation was also observed between the platelet count and PAIgG levels (r = -0.462, P < 0.01).


CONCLUSIONS
Autoimmune mechanism mediated by PAIg may play an important role in thrombocytopenia associated with viral hepatitis.
Jiang
Xiao-hua
XH
Department of Infectious Disease,Xiangya Hospital, Central South University, Changsha 410008, China. snakewin65@yahoo.com.cn
Xie
Yu-tao
YT
Tan
De-ming
DM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D007136:Immunoglobulins