Deciphering the model pathogenic fungus Cryptococcus neoformans.
Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.
Idnurm
Alexander
A
Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.
Bahn
Yong-Sun
YS
Nielsen
Kirsten
K
Lin
Xiaorong
X
Fraser
James A
JA
Heitman
Joseph
J
D000818:Animals; D003453:Cryptococcosis / Q000382:microbiology* / Q000503:physiopathology / Q000635:transmission; D003455:Cryptococcus neoformans / Q000235:genetics* / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D004251:DNA Transposable Elements; D016681:Genome, Fungal; D006801:Humans; D017422:Sequence Analysis, DNA; D015398:Signal Transduction; D014774:Virulence
D004251:DNA Transposable Elements