title: Coordination chemistry of N-aminopropyl pendant arm derivatives of mixed N/S-, and N/S/O-donor macrocycles, and construction of selective fluorimetric chemosensors for heavy metal ions.
abstract: The coordination chemistry of the N-aminopropyl pendant arm derivatives (L1c-4c) of the mixed donor macrocyclic ligands [12]aneNS2O, [12]aneNS3, [12]aneN2SO, and [15]aneNS2O2(L1a-4a) towards Cu(II), Zn(II), Cd(II), Hg(II), and Pb(II) in aqueous solution has been investigated. The protonation and stability constants with the aforementioned metal ions were determined potentiometrically and compared, where possible, with those of the unfunctionalised macrocycles. The measured values show that Hg(II) and Cu(II) in water have the highest affinity for all ligands considered, with the N-aminopropyl pendant arm weakly coordinating the metal centres. Crystals suitable for X-ray diffraction analysis were grown for the perchlorate salt (H2L1c)(ClO4)2.dmf, and for the 1 : 1 complexes [Cd(L3a)(NO3)2](1), [Cu(L4a)dmf](ClO4)2(2), [Zn(L1c)(ClO4)]ClO4(3), [Cd(L1c)(NO3)]NO3(4), and [Hg(L2c)](ClO4)2(5). Their structures show the macrocyclic ligands adopting a folded conformation, which for the 12-membered systems can be either [2424] or [3333] depending on the nature of the metal ion. L1c-4c were also functionalised at the primary amino pendant group with different fluorogenic subunits. In particular the N-dansylamidopropyl (Lnd, n= 1-4), and the N-(9-anthracenylmethyl)aminopropyl (Lne, n= 1, 2, 4, ) pendant arm derivatives of L1a-4a were synthesised and their optical responses to the above mentioned metal ions were investigated in MeCN/H2O (4 : 1 v/v) solutions.
authors.affiliation: Dipartimento di Chimica Inorganica ed Analitica, Università degli Studi di Cagliari, Complesso Universitario di Monserrato, S.S. 554 Bivio per Sestu, 09042, Monserrato, CA, Italy.
authors.forename: M Carla
authors.initials: MC
authors.lastname: Aragoni
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Arca
authors.forename: Andrea
authors.initials: A
authors.lastname: Bencini
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Blake
authors.forename: Claudia
authors.initials: C
authors.lastname: Caltagirone
authors.forename: Antonello
authors.initials: A
authors.lastname: Decortes
authors.forename: Francesco
authors.initials: F
authors.lastname: Demartin
authors.forename: Francesco A
authors.initials: FA
authors.lastname: Devillanova
authors.forename: Enrico
authors.initials: E
authors.lastname: Faggi
authors.forename: Luisa Stella
authors.initials: LS
authors.lastname: Dolci
authors.forename: Alessandra
authors.initials: A
authors.lastname: Garau
authors.forename: Francesco
authors.initials: F
authors.lastname: Isaia
authors.forename: Vito
authors.initials: V
authors.lastname: Lippolis
authors.forename: Luca
authors.initials: L
authors.lastname: Prodi
authors.forename: Claire
authors.initials: C
authors.lastname: Wilson
authors.forename: Barbara
authors.initials: B
authors.lastname: Valtancoli
authors.forename: Nelsi
authors.initials: N
authors.lastname: Zaccheroni
mesh_terms: D018360:Crystallography, X-Ray; D005456:Fluorescent Dyes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D047028:Macrocyclic Compounds / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D047028:Macrocyclic Compounds; D019216:Metals, Heavy; D009942:Organometallic Compounds