Redox regulation of the coagulation cascade.
Enhanced coagulation and thrombosis are linked to a variety of cardiovascular and metabolic diseases, as well as to cancer. Many of these diseases are also associated with enhanced levels of reactive oxygen species (ROS). Indeed, ROS have been made responsible for promoting many of these diseases. They have been shown not only to be cytotoxic, but also to serve as signaling molecules in a variety of cells. Recently, evidence accumulated that ROS and the redox state are also important in the control of blood coagulation and thrombosis.
Görlach
Agnes
A
Experimental Pediatric Cardiology, Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the Technical University Munich, Munich, Germany. goerlach@dhm.mhn.de
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008954:Models, Biological; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species; D013927:Thrombosis / Q000473:pathology
D017382:Reactive Oxygen Species; D010100:Oxygen