Classic Kaposi's sarcoma in Sardinia: HLA positive and negative associations.
BACKGROUND
The incidence of classic Kaposi's sarcoma (CKS) in northern Sardinia is one of the highest in the world.


METHODS
Sixty-two patients with CKS were typed for class I and class II antigens. All patients had been born and were living in northern Sardinia.


RESULTS
In the Sardinian patients, we observed a positive CKS association with Cw7, DRB1*1104, DRB1*1302, DQA1*0302, and DQB1*0604, and a negative CKS association with A30, B58, Cw5, DRB1*1601, and DQB1*0502.


CONCLUSIONS
The strong positive CKS association with DRB1*1104 and DQB1*0604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.
Masala
Maria Vittoria
MV
Department of Dermatology, University of Sassari, and Department of Medical Science, University of Cagliari, Italy. fcottoni@uniss.it
Carcassi
Carlo
C
Cottoni
Francesca
F
Mulargia
Marina
M
Contu
Licinio
L
Cerimele
Decio
D
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains