title: Establishment and characterization of human malignant lymphoma cell line derived from uterine cervix.
abstract: Human uterine cervical malignant lymphoma (B-cell type) was cultured and the cell line (HIUML) was newly established. The HIUML cells were round in shape and had a tendency to make floating clusters. The cells had a smooth surface or protrusion on the margin of the cytoplasm, and proliferate in floatation. The population doubling time was about 32 hours and 42 or more passages were successfully observed in two years. The HIUML cells were not transplantable into nude mice but were successfully done in the cheek pouch of hamster with formation of malignant lymphoma. Epstein-Barr virus was detected in the HIUML cells.
authors.affiliation: Department of Obstetrics and Gynecology, St.Marianna University School of Medicine.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kiguchi
authors.forename: Isamu
authors.initials: I
authors.lastname: Ishiwata
authors.forename: Chieko
authors.initials: C
authors.lastname: Ishiwata
authors.forename: Emiko
authors.initials: E
authors.lastname: Ishiwata
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Koshitaka
authors.forename: Masanori
authors.initials: M
authors.lastname: Iwata
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Okuda
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Yasuna
authors.initials: Y
authors.lastname: Wada
authors.forename: Bunpei
authors.initials: B
authors.lastname: Ishizuka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D006224:Cricetinae; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology* / Q000821:virology; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology* / Q000821:virology
chemical_list: D015703:Antigens, CD