title: IgA nephropathy in an Italian child with familial Mediterranean fever.
abstract: Familial Mediterranean fever is an autosomal recessive disorder characterized by transient attacks of fever and polyserositis with substantial risk of developing amyloidotic nephropathy over time. We report an Italian child with familial Mediterranean fever presenting with hematuria during attacks in whom kidney biopsy documented the presence of mesangial IgA deposits and the absence of amyloidosis. Kidney biopsy should be performed in patients showing microscopic or gross hematuria during attacks of familial Mediterranean fever in order to gain additional epidemiological data about specific features of renal involvement and to allow adequate treatment.
authors.affiliation: Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Largo A. Gemelli 8, 00168 Rome, Italy. drigante@libero.it
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Gilda
authors.initials: G
authors.lastname: Federico
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrara
authors.forename: Nicola
authors.initials: N
authors.lastname: Maggiano
authors.forename: Laura
authors.initials: L
authors.lastname: Avallone
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Pugliese
authors.forename: Achille
authors.initials: A
authors.lastname: Stabile
mesh_terms: D002675:Child, Preschool; D010505:Familial Mediterranean Fever / Q000150:complications*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology