Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection.
Since the initial report of unusual manifestations possibly associated with chronic active Epstein-Barr virus (EBV) infection (CAEBV), nearly three decades have passed. During this period, reported cases with this entity have dramatically increased in the world. Additionally, recent development of diagnostic procedures, including molecular biological and immunological techniques, have provided us with the ability to define certain diseases, especially malignant disorders. Guidelines, derived mainly from the current literature and recent experiences with CAEBV in Japan, for diagnosing CAEBV are proposed to clarify this enigmatic disease.
Okano
Motohiko
M
Department of Pediatrics, Hokkaido University Hospital, Hokkaido University Graduate School of Medicine, Sapporo, Japan. okano_m@iph.pref.hokkaido.jp
Kawa
Keisei
K
Kimura
Hiroshi
H
Yachie
Akihiro
A
Wakiguchi
Hiroshi
H
Maeda
Akihiko
A
Imai
Shosuke
S
Ohga
Shouichi
S
Kanegane
Hirokazu
H
Tsuchiya
Shigeru
S
Morio
Tomohiro
T
Mori
Masaaki
M
Yokota
Shumpei
S
Imashuku
Shinsaku
S
D000208:Acute Disease; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008967:Molecular Biology