[Apoptosis: basic knowledge and applications].
Apoptosis has become a most popular concept of cell death. What makes apoptosis particularly exciting for medicine is that its dysfunctions play a central role in the pathogenesis of several human diseases. This review summarizes the considerable knowledge about the cell death pathways. The purpose of this article is to provide a background of relevance to clinicians on apoptosis, and the rationale for future therapeutic interventions directed toward the apoptotic machinery.
Marchetti
P
P
Inserm U459, 1, place Verdun, 59045 Lille cedex, France. philippe.marchetti@lille.inserm.fr
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D053938:DNA Fragmentation; D003933:Diagnosis; D004789:Enzyme Activation; D006801:Humans; D009336:Necrosis; D013812:Therapeutics
D020169:Caspases