Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ.
The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1-3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.
Ueda
Yoshimi
Y
School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Oku
Hisae
H
Iinuma
Munekazu
M
Ishiguro
Kyoko
K
D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D035264:Flowers / Q000737:chemistry; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007073:Immunoglobulin E / Q000276:immunology; D029069:Impatiens / Q000737:chemistry*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009113:Muramidase / Q000276:immunology; D010972:Platelet Activating Factor / Q000494:pharmacology; D011537:Pruritus / Q000188:drug therapy* / Q000523:psychology; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D006993:Hypnotics and Sedatives; D010972:Platelet Activating Factor; D012701:Serotonin; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D009113:Muramidase