title: Assessment of the safety of a third dose of pneumococcal polysaccharide vaccine in the Vaccine Safety Datalink population.
abstract: There is little information on the safety of administration of a third dose of pneumococcal polysaccharide vaccine (PPV). The authors conducted a retrospective assessment of 316,995 adult members of three health maintenance organizations who had received one, two, or three PPV doses. Medical encounters associated with diagnosis codes potentially indicative of an injection site reaction in the week following a first, second, or third PPV dose were identified. These presumptive events occurred in 0.3% (911/279504) of the first PPV group, 0.7% (257/36888) of the second PPV group, and 0.5% (3/603) of the third PPV group (p>0.5 for both comparisons with the third PPV group). These findings do not suggest that a third PPV dose is associated with an increased risk of medically attended injection site reactions compared with a first or second PPV dose.
authors.affiliation: Center for Health Studies, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, USA. jackson.l@ghc.org
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Jackson
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Nelson
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Whitney
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Neuzil
authors.forename: Patti
authors.initials: P
authors.lastname: Benson
authors.forename: Darren
authors.initials: D
authors.lastname: Malais
authors.forename: James
authors.initials: J
authors.lastname: Baggs
authors.forename: John
authors.initials: J
authors.lastname: Mullooly
authors.forename: Steve
authors.initials: S
authors.lastname: Black
authors.forename: David K
authors.initials: DK
authors.lastname: Shay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006279:Health Maintenance Organizations; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*; D008485:Medical Audit; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D012189:Retrospective Studies; D014481:United States
chemical_list: D022242:Pneumococcal Vaccines