An autopsy case of imipramine poisoning.
We present a fatal imipramine poisoning. Quantitative analysis of imipramine and its metabolite, desipramine, was performed by high-performance liquid chromatography. The concentrations of imipramine and desipramine were 18.67 microg/mL and 6.21 microg/mL in heart blood and 6.90 microg/mL and 1.77 microg/mL in the femoral venous blood, respectively. We concluded that the cause of death was due to imipramine poisoning.
Kinoshita
Hiroshi
H
Department of Legal Medicine, Hyogo College of Medicine, Hyogo, Japan. kinochin@hyo-med.ac.jp
Taniguchi
Tadaaki
T
Kubota
Akira
A
Nishiguchi
Minori
M
Ouchi
Harumi
H
Minami
Takako
T
Utsumi
Takao
T
Motomura
Hiroyuki
H
Nagasaki
Yasushi
Y
Ameno
Kiyoshi
K
Hishida
Shigeru
S
D000929:Antidepressive Agents, Tricyclic / Q000097:blood / Q000506:poisoning*; D001344:Autopsy; D002423:Cause of Death; D002851:Chromatography, High Pressure Liquid; D003891:Desipramine / Q000097:blood / Q000378:metabolism; D062787:Drug Overdose / Q000401:mortality; D005260:Female; D005554:Forensic Medicine; D049429:Forensic Pathology; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D007564:Japan; D007684:Kidney Tubules / Q000473:pathology; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine; D003891:Desipramine