title: Hyperthyroidism and cerebral venous thrombosis.
abstract: The demonstration of an underlying prothrombotic condition in cerebral venous thrombosis (CVT) may have important practical consequences in terms of prevention. Thyrotoxicosis through a hypercoagulable state may be a predisposing factor for CVT. The authors present the cases of 4 patients who developed CVT and hyperthyroidism. At the acute stage, hyperthyroidism was associated with an increase in factor VIII (FVIII). At follow-up, FVIII level remained increased in 2 patients. Hyperthyroidism may have an impact on FVIII level. Accordingly in patients with hyperthyroidism and neurological symptoms, the diagnosis of CVT should be considered and an exhaustive coagulation screening may be appropriate.
authors.affiliation: Cerebrovascular Disease Center, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Mouton
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: M
authors.initials: M
authors.lastname: Berruyer
authors.forename: L
authors.initials: L
authors.lastname: Derex
authors.forename: F
authors.initials: F
authors.lastname: Philippeau
authors.forename: S
authors.initials: S
authors.lastname: Cakmak
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: M
authors.initials: M
authors.lastname: Hermier
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
mesh_terms: D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000150:complications; D020767:Intracranial Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged
chemical_list: D005169:Factor VIII