White matter lesion severity in male and female patients with Fabry disease.
In male patients with Fabry disease (FD), significant age-related cerebral white matter lesions (WMLs) can be found. Although characteristic symptoms including cerebrovascular events are highly prevalent also in females with FD, cerebral structural changes have not been investigated in female FD patients yet. The authors quantified the WML load of 13 male and 14 age-matched female patients with FD and could demonstrate a comparably high frequency and severity of WMLs in both groups.
Fellgiebel
A
A
Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany. fellgiebel@psychiatrie.klinik.uni-mainz.de
Müller
M J
MJ
Mazanek
M
M
Baron
K
K
Beck
M
M
Stoeter
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002536:Cerebral Arteries / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D000795:Fabry Disease / Q000150:complications*; D005260:Female; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects
D053327:Apolipoprotein E4; D001057:Apolipoproteins E