title: Substitution of thoracic oesophagus by interposition of a pedicled gastric tube, preserving LES function: clinical and histological follow-up.
abstract: Assessment of clinical evolution and histological findings in a group of animals experimentally operated on to substitute the thoracic oesophagus with a gastric tube. Six piglets underwent oesophageal replacement with a gastric tube, constructed from the greater curvature of stomach and pedicled on the gastroepiploic vessels, which was interposed between the oesophageal stumps. At follow-up, all animals were found to be growing and eating normally, apart from case no 1 (stenosis of the lower oesophageal anastomosis). Ph-metry showed a neutral pH on the gastric tube. Postmortem histological analysis of the gastric tube and native oesophagus samples did not show any significant lesions, except in case no 1 (inflammation of the gastric tube and upper oesophagus due to food stasis). The technique of substitution of the oesophagus with an interposed pedicled gastric tube can be a breakthrough in existing surgical methods of oesophageal replacement.
authors.affiliation: Unit of Pediatric Surgery, University of Sassari, Sassari, Italy. antoniodessanti@yahoo.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Dessanti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Benedetto
authors.forename: Marco
authors.initials: M
authors.lastname: Iannuccelli
authors.forename: Eraldo
authors.initials: E
authors.lastname: Sanna-Passino
authors.forename: Liliana
authors.initials: L
authors.lastname: Mura
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Dessanti
authors.forename: Gian Mario
authors.initials: GM
authors.lastname: Careddu
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Manunta
authors.forename: Paolo
authors.initials: P
authors.lastname: Cossu-Rocca
authors.forename: Ennio
authors.initials: E
authors.lastname: Sanna
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004933:Esophageal Atresia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016629:Esophagectomy; D004947:Esophagus / Q000473:pathology / Q000503:physiopathology; D005500:Follow-Up Studies; D006863:Hydrogen-Ion Concentration; D010528:Peristalsis / Q000502:physiology*; D019651:Plastic Surgery Procedures / Q000379:methods*; D013270:Stomach / Q000637:transplantation*; D013552:Swine; D016896:Treatment Outcome