title: [Chromosomal aberrations in myelodysplastic syndrome].
abstract: OBJECTIVE
  To analyse incidence rate of chromosomal aberrations in myelodysplastic syndromes (MDS), specification of clinicomorphological features of some cytogenetic variants.
  
  
  METHODS
  Chromosomal analysis by the method of G-differential staining of chromosomes was made in 209 patients with different variants of MDS. RESULTS; Clonal chromosomal aberrations occured in 60.8%. The following aberrations were found most frequently: deletion of the long arm of the chromosome 5 (del(5q)) - 34.6%, trisomy of chromosome 8 (14.1%), monosomy of chromosome 7 (13.4%), aberrations 3q21q26 (12.6%), aberrations of a long arm of X-chromosome (4.7%), the absence of Y-chromosome (3.1%). Complex aberrations of karyotype were found in 13.5% cases. Chromosomal aberrations determined not only clinical and morphological features but also the prognosis of the disease.
  
  
  CONCLUSIONS
  Cytogenetic examination is an essential component of MDS patients examination. It allows more precise classification of MDS variant and prognostification of the disease course.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Ol'shanskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Domracheva
authors.forename: A I
authors.initials: AI
authors.lastname: Udovichenko
authors.forename: L A
authors.initials: LA
authors.lastname: Vodinskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Zakharova
authors.forename: E N
authors.initials: EN
authors.lastname: Parovichnikova
authors.forename: N V
authors.initials: NV
authors.lastname: Tsvetaeva
authors.forename: E A
authors.initials: EA
authors.lastname: Mikhaĭlova
authors.forename: E N
authors.initials: EN
authors.lastname: Glasko
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Kolosova
authors.forename: A N
authors.initials: AN
authors.lastname: Kokhno
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Tikhonova
authors.forename: T V
authors.initials: TV
authors.lastname: Shitareva
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: G A
authors.initials: GA
authors.lastname: Alimova
authors.forename: A D
authors.initials: AD
authors.lastname: Shirin
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Vinogradova
authors.forename: N D
authors.initials: ND
authors.lastname: Khoroshko
authors.forename: V G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies; D014314:Trisomy / Q000235:genetics / Q000473:pathology