title: [Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure].
abstract: OBJECTIVE
  In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure.
  
  
  METHODS
  Twenty-four patients (mean age: 55+/-8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values.
  
  
  RESULTS
  Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolol treatment (p<0.05).
  
  
  CONCLUSIONS
  Metoprolol treatment can cause an improvement in transmitral and pulmonary venous flows.
authors.affiliation: Department of Cardiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey.
authors.forename: Sait Mesut
authors.initials: SM
authors.lastname: Doğan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aydin
authors.forename: Metin
authors.initials: M
authors.lastname: Gürsürer
authors.forename: Aydin
authors.initials: A
authors.lastname: Dursun
authors.forename: Fatih
authors.initials: F
authors.lastname: Cam
authors.forename: Tolga
authors.initials: T
authors.lastname: Onuk
authors.forename: Hediye
authors.initials: H
authors.lastname: Madak
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001783:Blood Flow Velocity / Q000187:drug effects; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D008943:Mitral Valve / Q000187:drug effects* / Q000502:physiology; D011667:Pulmonary Veins / Q000187:drug effects* / Q000502:physiology; D011673:Pulsatile Flow / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol