The Ezh2 methyltransferase complex: actin up in the cytosol.
Ezh2, a polycomb group protein, is known to function in histone methylation, thereby regulating gene expression. However, in a recent study by Su et al., the Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner. Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events.
Nolz
Jeffrey C
JC
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Gomez
Timothy S
TS
Billadeau
Daniel D
DD
D000199:Actins / Q000378:metabolism*; D000818:Animals; D003600:Cytosol / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000502:physiology; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D046912:Multiprotein Complexes; D009687:Nuclear Proteins / Q000378:metabolism*; D063151:Polycomb Repressive Complex 2; D051567:Proto-Oncogene Proteins c-vav / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*
D000199:Actins; D029721:Drosophila Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D051567:Proto-Oncogene Proteins c-vav; D012097:Repressor Proteins; C496618:VAV1 protein, human; C083329:E(z) protein, Drosophila; D063151:Polycomb Repressive Complex 2; D008239:Lysine