title: [Primary HIV-1 infection in Zurich: 2002-2004].
abstract: Acute HIV-infection mostly presents with unspecifc symptoms. Thus the acute retroviral syndrome is often not readily recognized. Here we present an interim analysis of a prospective study from 62 patients with documented acute HIV infection acquired between January 2002-August 2004 in the greater Zurich area. 61.5% of patients were infected by homosexual contacts, mostly with HIV-1 subtype B, 34% acquired infection by heterosexual contacts, often with non-B-virus subtypes. Transmission occurred in all sexually active age groups (18-72 years). Clinical symptoms presented as follows: fever (77%), pharyngitis (56%), fatigue (52%), gastrointestinal symptoms (45%), rash (39%). On first physician contact, an ARS was only suspected in 27% of the cases. Patients primarily called on their family doctors (37.5%), went to see larger walk in clinics or emergency rooms (37.5%), and 16% were hospitalised. In 16% of patients other sexually transmitted diseases were diagnosed contemporaneously. Drug resistant virus (single class resistance) was transmitted in only one patient.
authors.affiliation: Abteilung für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich.
authors.forename: L
authors.initials: L
authors.lastname: Aceto
authors.forename: U
authors.initials: U
authors.lastname: Karrer
authors.forename: Ch
authors.initials: Ch
authors.lastname: Grube
authors.forename: R
authors.initials: R
authors.lastname: Oberholzer
authors.forename: B
authors.initials: B
authors.lastname: Hasse
authors.forename: E
authors.initials: E
authors.lastname: Presterl
authors.forename: J
authors.initials: J
authors.lastname: Böni
authors.forename: H
authors.initials: H
authors.lastname: Kuster
authors.forename: A
authors.initials: A
authors.lastname: Trkola
authors.forename: R
authors.initials: R
authors.lastname: Weber
authors.forename: H F
authors.initials: HF
authors.lastname: Günthard
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D015497:HIV-1; D020010:Heterosexuality; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013557:Switzerland / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents