title: Synthesis of heavily substituted 1,2-amino alcohols in enantiomerically pure form.
abstract: [reaction: see text] A simple and convenient methodology for the preparation of optically pure 2-amino-2-aryl-1,1-diphenylethanols is presented. Allylamine was found to produce the ring-opening of triaryloxiranes in a regioselective and a stereospecific fashion. Removal of the allyl protecting group provided the free 1,2-amino alcohols in enantiomerically pure form.
authors.affiliation: Unitat de Recreca en Síntesi Asimètrica (URSA-PCB), Parc Científic de Barcelona and Departament de Química Orgànica, Universitat de Barcelona, c/Josep Samitier, 1-5, E-08028 Barcelona, Spain.
authors.forename: Noemí
authors.initials: N
authors.lastname: García-Delgado
authors.forename: Katamreddy Subba
authors.initials: KS
authors.lastname: Reddy
authors.forename: Lluís
authors.initials: L
authors.lastname: Solà
authors.forename: Antoni
authors.initials: A
authors.lastname: Riera
authors.forename: Miquel A
authors.initials: MA
authors.lastname: Pericàs
authors.forename: Xavier
authors.initials: X
authors.lastname: Verdaguer