[Genetic risks in embryo donation].
Embryo donation is now an acceptable practice which offers new therapeutic possibilities to many infertile couples. It can be proposed for genetic reasons like the existence of hereditary diseases in the families of both members of a couple, leading to a high risk of transmission to a child, or when a male or female sterility is associated with a transmissible genetic abnormality from the other partner. Embryos eligible for donation may have been conceived by in vitro fertilization performed because of a male or female infertility of genetic origin. As a consequence, they are considered at increased risk of carrying a known or unknown genetic abnormality related to parental infertility. A consultation should be provided before donation acceptation for defining exactly the causes of the initial in vitro fertilization and checking the genetic screening in the couple. According to recent guidelines established by the Genetics Commission of the French Federation of CECOS, some embryos could be excluded from donation process.
Siffroi
J-P
JP
Service d'histologie, biologie de la reproduction et cytogénétique, hôpital Tenon (AP-HP), 4, rue de la Chine, 75020 Paris, France. jean-pierre.siffroi@tnn.aphp.fr
D000328:Adult; D000375:Aging; D004622:Embryo, Mammalian; D005260:Female; D030342:Genetic Diseases, Inborn; D006801:Humans; D007246:Infertility / Q000235:genetics; D008297:Male; D008423:Maternal Age; D012307:Risk Factors; D014019:Tissue Donors