title: [Acute coronary syndrome in the prehospital phase].
abstract: Cardiovascular diseases are the number one cause of death in Germany. In 2002 about 70,000 people died of acute myocardial infarction (AMI) and of these 37% died before arrival at hospital which underlines the relevance of adequate prehospital care. The generic term acute coronary syndrome (ACS) was introduced because a single pathomechanism accounts for the different forms and comprises unstable angina pectoris (iAP), non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI) and sudden cardiac death (SCD). Characteristic features are retrosternal pain, vegetative symptoms and radiation of pain into the adjoining regions. Further differentiation can only be achieved by the 12-lead ECG, as cardiac-specific enzymes do not play a role in prehospital decisions. Prehospital delays should be avoided, history and physical examination should be brief but focused, vital parameters should be assessed and monitored. Basic treatment for ACS should comprise inhalative oxygen, nitrates, morphine, aspirin and beta-blockers. If STEMI is diagnosed, patients with symptoms <12 h should undergo fibrinolytic therapy unless there is primary percutaneous coronary intervention (PCI) available within 90 min or if contraindicated. Heparin should be given to patients with STEMI depending on the choice of fibrinolytic agent, it otherwise results in a higher risk of bleeding, but in patients with iAP or NSTEMI it reduces mortality. All patients must be accompanied by the emergency physician during transportation and should be brought to a hospital with primary PCI, especially those with complicated ACS. Treatment of complications depends largely on the type, persistence and severity.
authors.affiliation: Klinik für Anaesthesiologie, Universitätsklinikum, Heidelberg. Jan.schiff@med.uni-heidelberg.de
authors.forename: J-H
authors.initials: JH
authors.lastname: Schiff
authors.forename: H R
authors.initials: HR
authors.lastname: Arntz
authors.forename: B W
authors.initials: BW
authors.lastname: Böttiger
mesh_terms: D000208:Acute Disease; D000787:Angina Pectoris / Q000401:mortality / Q000628:therapy; D002317:Cardiovascular Agents / Q000627:therapeutic use; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D004562:Electrocardiography; D004632:Emergency Medical Services; D005858:Germany / Q000453:epidemiology; D006801:Humans; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy
chemical_list: D002317:Cardiovascular Agents