title: [Evaluation of Hypericum perforatum toxicity when administered to pregnant rats].
abstract: BACKGROUND
  Saint John's wort (Hypericum perforatum) is a medicinal plant used in the treatment of depression and other psychiatric disorders.
  
  
  OBJECTIVE
  In the present paper, the toxicity of H. perforatum administered to female rats during organogenesis (9th to 15th day of pregnancy) was evaluated.
  
  
  METHODS
  Thirty inseminated Wistar rats were randomly distributed into Control and Treated groups, which received by gavage, respectively, 0.5 ml of saline and 36 mg/Kg body weight of Jarsin dried extract diluted into 0.5 ml of saline. Maternal toxicity was evaluated by means of: water and food intake, body weight, piloerection, walking activity, diarrhea and death. Animals were killed on the 21st day of pregnancy, when kidneys, liver and ovaries were weighed. Implantation and reabsorption indices were calculated, as well as the average number of fetuses per mother.
  
  
  RESULTS
  Clinical signs of maternal toxicity were not observed and none of the variables analyzed showed statistically significant differences.
  
  
  CONCLUSIONS
  At the dose administered in the experimental model used, H. perforatum does not seem to be toxic to the mother.
authors.affiliation: Centro de Biologia da Reprodução, Universidade Federal de Juiz de Fora e ne farmácia de manipulação Las Casas, Juiz de Fora, Minas Gerais (MG), Brazil.
authors.forename: Luciana Valente
authors.initials: LV
authors.lastname: Borges
authors.forename: Juliana Corrêia do
authors.initials: JC
authors.lastname: Carmo
authors.forename: Vera Maria
authors.initials: VM
authors.lastname: Peters
authors.forename: Lucimar
authors.initials: L
authors.lastname: Las Casas
authors.forename: Martha de Oliveira
authors.initials: Mde O
authors.lastname: Guerra
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D020902:Hypericum / Q000633:toxicity*; D038081:Organogenesis / Q000187:drug effects*; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000928:Antidepressive Agents