Lipoprotein lipase is expressed by glomerular mesangial cells.
Lipoprotein lipase expressed by the vasculature plays a key role in atherogenesis by enhancing the binding and uptake of lipoproteins and, thereby, leading to the formation of lipid-loaded foam cells. Hyperlipidemia also accelerates the progression of glomerular diseases and addition of exogenous lipoprotein lipase to mesangial cells has been shown to lead to an enhanced binding of lipoproteins to these cells. Despite such potential importance, the expression of endogenous lipoprotein lipase by cells of the glomeruli has, as yet, not been investigated. We show here for the first time that mesangial cells, but not epithelial cells, express lipoprotein lipase. The minimal lipoprotein lipase gene promoter was active in mesangial cells and inhibited by interferon-gamma, which is known to suppress its expression.
Irvine
Scott A
SA
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK.
Martin
John
J
Hughes
Timothy R
TR
Ramji
Dipak P
DP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D050197:Atherosclerosis / Q000201:enzymology / Q000473:pathology; D002460:Cell Line; D005487:Foam Cells / Q000201:enzymology / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology*; D005920:Glomerular Mesangium / Q000166:cytology / Q000201:enzymology*; D005921:Glomerulonephritis / Q000201:enzymology / Q000473:pathology; D006949:Hyperlipidemias / Q000201:enzymology / Q000473:pathology; D007371:Interferon-gamma / Q000494:pharmacology; D008071:Lipoprotein Lipase / Q000096:biosynthesis*; D051379:Mice; D011401:Promoter Regions, Genetic / Q000502:physiology*
D000970:Antineoplastic Agents; D007371:Interferon-gamma; D008071:Lipoprotein Lipase