Evaluation of in vitro drug release, pH change, and molecular weight degradation of poly(L-lactic acid) and poly(D,L-lactide-co-glycolide) fibers.
Biodegradable fibers of poly(L-lactic acid) (PLLA) and poly(D,L-lactide-co-glycolide) (PLGA) that encapsulated a water-soluble drug were created by a patented technique consisting of wet-spinning a water-in-oil emulsion. These fibers are 2.4% by mass drug, which is slowly released, making these fibers potential candidates for implantation as drug delivery devices and/or tissue-engineering substrates. Drug release kinetics and changes in molecular weight were investigated over time. This study demonstrated that drug release rates and molecular weight degradation are a function of the amount of aqueous phase added as an emulsion during fabrication. The type of polymer used (PLLA or PLGA) determines the molecular weight degradation rates, but has little effect on drug release kinetics.
Crow
B B
BB
Joint Program in Biomedical Engineering, University of Texas Southwestern Medical Center at Dallas, USA.
Borneman
A F
AF
Hawkins
D L
DL
Smith
G M
GM
Nelson
K D
KD
D020341:Absorbable Implants; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry*; D004343:Drug Implants / Q000032:analysis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D019344:Lactic Acid / Q000032:analysis / Q000737:chemistry*; D008422:Materials Testing; D008970:Molecular Weight; D010865:Pilot Projects; D011091:Polyesters; D011100:Polyglycolic Acid / Q000032:analysis / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000032:analysis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage* / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D004343:Drug Implants; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; C033616:poly(lactide)