title: Drugs from emasculated hormones: the principle of syntopic antagonism.
abstract: This lecture outlines the early stages in the discovery of adrenaline beta-receptor antagonists and of the histamine H2-receptor antagonists. It ends with a brief personal view about future research.
authors.affiliation: Department of Analytical Pharmacology Rayne Institute, King's College School of Medicine & Dentistry, 123 Coldharbour Lane, SE5 9NU, London, UK.
authors.forename: James
authors.initials: J
authors.lastname: Black
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001671:Biochemistry / Q000379:methods*; D001695:Biology / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D006632:Histamine / Q000737:chemistry; D006635:Histamine H2 Antagonists / Q000737:chemistry / Q000494:pharmacology*; D006728:Hormones / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D009613:Nobel Prize; D010101:Oxygen Consumption; D011943:Receptors, Adrenergic, beta / Q000737:chemistry*; D011970:Receptors, Histamine H2 / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000319:Adrenergic beta-Antagonists; D006635:Histamine H2 Antagonists; D006728:Hormones; D011943:Receptors, Adrenergic, beta; D011970:Receptors, Histamine H2; D006632:Histamine