Therapeutic total plasma exchange in a child with neuroblastoma-related anti-Hu syndrome.
A 5-year-old boy underwent total plasma exchange to remove anti-neuronal anti-Hu autoantibodies as a complication of neuroblastoma, leading to autonomic bowel dysfunction. Total plasma exchange (TPE) resulted eventually in a reduction of autoantibody levels, but, more importantly, led to improvement of bowel function. TPE proved to be a safe and effective treatment option in neuroblastoma-related anti-Hu syndrome in a child.
van Vuurden
Dannis G
DG
Department of Pediatrics, VU Medical Center, Amsterdam, The Netherlands.
Plötz
Frans B
FB
de Jong
Miranda
M
Bokenkamp
Arend
A
van Wijk
Joanna A E
JA
D001323:Autoantibodies / Q000097:blood; D002675:Child, Preschool; D051959:ELAV Proteins / Q000276:immunology*; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000276:immunology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000276:immunology / Q000628:therapy*; D010951:Plasma Exchange; D013120:Spinal Cord Neoplasms / Q000276:immunology*
D001323:Autoantibodies; D051959:ELAV Proteins