title: [The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles].
abstract: OBJECTIVE
  To investigate the tissue distribution and pharmacokinetics of oridonin-solid lipid nanoparticles in animals.
  
  
  METHODS
  HPLC method was established to determine the concentration of oridonin in serum of rabbits and in different tissues of mice. The results after tail iv administration of oridonin and oridonin solid lipid nanoparticles were compared.
  
  
  RESULTS
  The relative tissue content of oridonin of solid lipid nanoparticles in the liver, spleen, lung, heart and kidney were 4.25%, 3.44%, 1.19%, 0.52% and 0.60%, respectively. The concentration-time curves of oridonin and oridonin solid lipid nanoparticles were both fitted to the three-compartment model. T(1/2)pi = 0.087 h, T(1/2)alpha = 1.65 h, T(1/2)beta = 32.36 h, V(C) = 0.66 mL.kg(-1).
  
  
  CONCLUSIONS
  Solid lipid nanoparticles could increase the hepatic and lienic targeting efficiency of oridonin in mice and improve its bioavailability. Solid lipid nanoparticles were helpful for oridonin to reach a long circulation time and were hopeful to be its novel drug carrier.
authors.affiliation: College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. zhangdrsy@eyou.com
authors.forename: Dian-Rui
authors.initials: DR
authors.lastname: Zhang
authors.forename: Tian-Chi
authors.initials: TC
authors.lastname: Ren
authors.forename: Hong-Xiang
authors.initials: HX
authors.lastname: Lou
authors.forename: Jie
authors.initials: J
authors.lastname: Xing
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D019540:Area Under Curve; D004224:Diterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D007275:Injections, Intravenous; D037602:Isodon / Q000737:chemistry; D008055:Lipids; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D053758:Nanoparticles; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004337:Drug Carriers; D008055:Lipids; C011959:oridonin