[Detection of apoptotic markers in human ejaculated spermatozoa as new methods in human reproductive biology].
Ejaculated spermatozoa, particularly in infertile men, have been shown to display numerous features that are typical of apoptosis in somatic cells including Fas expression, ROS production, activation of caspases, DNA fragmentation, reduction in mitochondrial membrane potential, plasma membrane translocation of phosphatidylserine and permeability. In this review we summarize the biological significance and the potential role of these markers in the exploration of men infertility.
Marchetti
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C
Laboratoire de biologie de la reproduction, hôpital Jeanne-de-Flandre, CHRU de Lille, 2, avenue Oscar-Lambret, 59037 Lille cedex, France. c-marchetti@chru-lille.fr
Marchetti
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P
D017209:Apoptosis; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D053938:DNA Fragmentation; D004789:Enzyme Activation; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism / Q000473:pathology; D007425:Intracellular Membranes / Q000502:physiology; D008297:Male; D008564:Membrane Potentials; D008928:Mitochondria / Q000648:ultrastructure; D010718:Phosphatidylserines / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000032:analysis; D013094:Spermatozoa / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D019014:fas Receptor / Q000032:analysis
D015415:Biomarkers; D010718:Phosphatidylserines; D017382:Reactive Oxygen Species; D019014:fas Receptor; D020169:Caspases