Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans.
Dereplication of the antifungal extracts of Aspergillus flavus indicated that the primary antifungal compound present was the known aspirochlorine (1). Preparative isolation work resulted in the identification of the new compounds tetrathioaspirochlorine (2) and cyclo(D-N-methyl-Leu-L-Trp) (3).
Klausmeyer
Paul
P
Natural Products Support Group, SAIC-Frederick, Inc., Bldg 431, FCRDC, Frederick, Maryland 21702-1201, USA.
McCloud
Thomas G
TG
Tucker
Kenneth D
KD
Cardellina
John H
JH
Shoemaker
Robert H
RH
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000737:chemistry*; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D025141:Drug Resistance, Fungal; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; D001393:Azoles; D009183:Mycotoxins; D013141:Spiro Compounds; C119402:aspirochlorine; C504683:tetrathioaspirochlorine