title: Antiseptic resistance: what do we know and what does it mean?
abstract: Biocides (antiseptics, disinfectants, preservatives, sterilants) are used in clinical medicine as intervention strategies that prevent the dissemination of nosocomial pathogens. Biocides are also used for personal hygiene and to prevent cross-contamination of food-borne pathogens in homes, restaurants, day care centers, and nursing homes. However, laboratory evidence has emerged suggesting that the mechanism of nonsusceptibility to biocides may counter-select for resistance to antibiotics. Nature conserves successful survival strategies. Using existing mechanisms of resistance to antibiotics and their means of dissemination, microorganisms have adopted this same survival strategy for biocide nonsusceptibility. These mechanisms are intrinsic in nature or are acquired. The consequences to biocide efficacy in the clinical setting are probably not significant from the biocide perspective. But, the selective pressure biocides exert on bacterial populations that have mechanisms of resistance similar to those to antibiotics or that are also substrates for antibiotic resistance is of concern.
authors.affiliation: Antibiotic and Antiseptic Consultants Inc, Silver Spring, MD, USA. ATSheldon@Starpower.net
authors.forename: Albert T
authors.initials: AT
authors.lastname: Sheldon
mesh_terms: D000222:Adaptation, Physiological; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D012641:Selection, Genetic
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local