[Expression and significance of EBV LMP2A in nasopharyngeal cancer specimens].
OBJECTIVE
To investigate the expression of Epstein-Barr Virus (EBV) latent membrane protein 2A (LMP2A) in tumor tissues of nasopharyngeal cancer (NPC) and discuss the possibility (feasibility) that LMP2A was selected (to select <of selecting> LMP2A ) as a target antigen in immunologic treatment of NPC.


METHODS
The expression of EBV LMP2A was detected in the specimens of 40 patients with NPC and 38 cases with nasopharyngeal inflammation by S-P immunohistochemical methods.


RESULTS
Of the 40 NPC specimens, 36 cases expressed LMP2A. There was no significant relationship between the expression of LMP2A and the histological differentiation of NPC. Thirty-three of the 38 cases with nasopharyngeal inflammation showed negative expression of LMP2A. There was a significant difference of LMP2A expression between NPC and nasopharyngeal inflammation.


CONCLUSIONS
The expression of EBV LMP2A is confirmed in the NPC specimens,and the negative results are seen in the majority of the inflammation cases. There is a possibility of applying LMP2A target antigen to induce specific immunoreaction to kill tumor cells of NPC.
Xu
Jiejie
J
Department of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yao
Kun
K
Yu
Chenjie
C
Chen
Xi
X
Li
Baizhou
B
Sun
Hua
H
Zhou
Feng
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D014763:Viral Matrix Proteins / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins