A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia.
The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.
Yu
Yaqin
Y
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China.
Tao
Ran
R
Shi
Jieping
J
Zhang
Xiaojuan
X
Kou
Changgui
C
Guo
Yingjun
Y
Zhang
Xuan
X
Lin
Xie
X
Liu
Shuzheng
S
Ju
Guizhi
G
Xu
Qi
Q
Shang
Hong
H
Shen
Yan
Y
Wei
Jun
J
D000328:Adult; D002681:China / Q000453:epidemiology; D003600:Cytosol / Q000201:enzymology*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D054522:Group VI Phospholipases A2; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*
D005819:Genetic Markers; D010741:Phospholipases A; D054522:Group VI Phospholipases A2; C516475:PLA2G6 protein, human; D054467:Phospholipases A2