[Transcatheter hepatic arterial chemoembolization on recurrent hepatocellular carcinoma after resection].
OBJECTIVE
To investigate the effect of transcatheter hepatic arterial chemoembolization (TACE) therapy on the survival and prognosis of recurrent hepatocellular carcinoma (HCC) after surgical resection.


METHODS
The data of 130 surgically resected but recurrent HCC patients treated by TACE were reviewed retrospectively. The survival and influencing factors on the prognosis were analyzed.


RESULTS
The overall 1-, 3-, 5-year survival rates of these 130 patients were 83.0%, 45.5% and 17.6% respectively (median survival time 2.4 years). Ninty-four of the series were treated with TACE alone, which gave the 1-, 3- year survival rates of 76.4% and 37.1%, respectively (median survival time 2.1 years). Thirty-six out of 130 patients treated with TACE plus percutaneous ethanol injection (PEI), the 1-, 3-year survival rates were 100.0% and 66.5% respectively with a median survival time (MST) of 3.5 years. The survival of TACE plus PEI group was significantly better, and the mortality risk was significantly lower than that of TACE alone group (P < 0.05). The mortality risk of those with > 5 cm diameter recurrent tumor or with distant metastasis was significantly higher than those with < or = 5 cm diameter tumor or without metastasis (P < 0.05).


CONCLUSIONS
TACE combined with PEI may improve the survival of recurrent HCC patients.
Ge
Ning-ling
NL
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Ren
Zheng-gang
ZG
Ye
Sheng-long
SL
Lin
Zhi-ying
ZY
Xia
Jing-lin
JL
Gan
Yu-hong
YH
Li
Li-xin
LX
Shen
Yue-fang
YF
Tang
Zhao-you
ZY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D011184:Postoperative Period; D016896:Treatment Outcome
D000431:Ethanol; D016685:Mitomycin; D007459:Iodized Oil; D002945:Cisplatin; D005472:Fluorouracil