title: Insulin-like growth factor binding protein-1 detection in preterm labor: evaluation of a bedside test.
abstract: Phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) is secreted by decidual cells and may leak into cervical secretions during detachment of the fetal membrane. The aim of this study was to determine whether a rapid bedside test for phIGFBP-1 predicts preterm birth in women with preterm uterine contractions. This was a prospective study of pregnant women who sought medical care for symptoms of preterm labor. Cervical swabs were assayed for the presence of phIGFBP-1 by a rapid bedside test. Sixty-four patients were enrolled. Eleven of them (17%) delivered preterm (< 35 weeks). phIGFBP-1 in cervical secretions predicted preterm birth with a sensitivity of 72.7%, a specificity of 83.0%, a positive predictive value of 47.0%, and negative predictive value of 93.6%. Positive phIGFBP-1 bedside test in women with preterm uterine contractions may indicate a significant risk for subsequent preterm birth. The absence of phIGBP-1 is a reassuring sign that the likelihood of preterm birth is low.
authors.affiliation: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Shai E
authors.initials: SE
authors.lastname: Elizur
authors.forename: Yoav
authors.initials: Y
authors.lastname: Yinon
authors.forename: Gil S
authors.initials: GS
authors.lastname: Epstein
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Seidman
authors.forename: Eyal
authors.initials: E
authors.lastname: Schiff
authors.forename: Eyal
authors.initials: E
authors.lastname: Sivan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D016015:Logistic Models; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000378:metabolism*; D016017:Odds Ratio; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple / Q000378:metabolism; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D018970:Insulin-Like Growth Factor Binding Protein 1