Effect of Cassia auriculata Linn. root extract on cisplatin and gentamicin-induced renal injury.
The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide free-radical-scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property.
Annie
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Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India. annie.shirwaikar@cops.manipal.edu
Rajagopal
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PL
Malini
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D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D000284:Administration, Oral; D000818:Animals; D002366:Cassia; D002945:Cisplatin; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use*; D005839:Gentamicins; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D018517:Plant Roots; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D014508:Urea / Q000097:blood
D016166:Free Radical Scavengers; D005839:Gentamicins; D010936:Plant Extracts; D020011:Protective Agents; D014508:Urea; D003404:Creatinine; D002945:Cisplatin