title: Effects of helium-neon laser irradiation and local anesthetics on potassium channels in pond snail neurons.
abstract: Intracellular dialysis and membrane voltage clamping were used to show that He-Ne laser irradiation of a pond snail neuron at a dose of 0.7 x 10(-4) J (power density 1.5 x 10(2) W/m2) increases the amplitude of the potential-dependent slow potassium current, while a dose of 0.7 x 10(-3) J decreases this current. Bupivacaine suppresses the potassium current. Combined application of laser irradiation at a dose of 0.7 x 10(-3) J increased the blocking effect of 10 microM bupivacaine on the slow potassium current, while an irradiation dose of 0.7 x 10(-4) J weakened the effect of bupivacaine.
authors.affiliation: Academician I. P. Pavlov St. Petersburg State Medical University, Ministry of Health of the Russian Federation, 6/8 Lev Tolstoy Street, 197022, St. Petersburg, Russia.
authors.forename: Yu D
authors.initials: YD
authors.lastname: Ignatov
authors.forename: A I
authors.initials: AI
authors.lastname: Vislobokov
authors.forename: T D
authors.initials: TD
authors.lastname: Vlasov
authors.forename: M E
authors.initials: ME
authors.lastname: Kolpakova
authors.forename: K N
authors.initials: KN
authors.lastname: Mel'nikov
authors.forename: I N
authors.initials: IN
authors.lastname: Petrishchev
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D006371:Helium; D007834:Lasers; D028022:Low-Level Light Therapy; D008195:Lymnaea / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D009356:Neon; D009474:Neurons / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
chemical_list: D000779:Anesthetics, Local; D015221:Potassium Channels; D006371:Helium; D009356:Neon; D002045:Bupivacaine