Development of hepatocellular carcinoma following treatment with 6-mercaptopurine for ulcerative colitis: investigation of chromosomal aberration by comparative genomic hybridization.
In a 64-year-old man who had been treated with prednisolone (PSL) and 6-mercaptopurine (6MP) for a long period, for ulcerative colitis (UC), hepatocellular carcinoma (HCC) was detected incidentally. The UC was in remission with these medications. After he had been taking these medications for about 8 years, HCC was detected by computed tomography (CT), done for the evaluation of an other disease. Blood chemistry examination results were normal, except that the protein induced by vitamin K antagonist (PIVKA)-II level was 7940 AU/ml. We performed resection of liver segment V. With comparative genomic hybridization, chromosomal aberrations were recognized; these were gains of 1q, 3ptel-21, 8p12, and 22q11.23-22q13.1. Generally, HCC is associated with hepatitis virus infection in most cases, but in this patient, the HCC was not related to hepatitis C virus (HCV) or HBV. It is presumed that this case was related to the immunosuppressive therapy for UC and was associated with the gains of 1q, 3p, and 8p.
Nakao
Kentaro
K
Second Department of Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Tokyo 146-8666, Japan. knakao@med.showa-u.ac.jp
Tsunoda
Akira
A
Shimizu
Yoshinori
Y
Takenaka
Koji
K
Morohara
Koji
K
Suzuki
Naoto
N
Yamazaki
Katsuo
K
Aoki
Takeshi
T
Hoshino
Mitsunori
M
Kusano
Mitsuo
M
Kitadai
Eri
E
Kurihara
Toshikazu
T
Takeuchi
Yoshiaki
Y
Imawari
Michio
M
D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000235:genetics; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000276:immunology; D005784:Gene Amplification; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000235:genetics; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents; D015122:Mercaptopurine