Zirconium mediated total synthesis of crinitol, 9-hydroxyfarnesoic acid, 9-hydroxyfarnesol, 9-hydroxysargaquinone and the selectively-protected aglycone of moritoside and euplexide A.
Tandem formation of an unsaturated zirconacycle, insertion of methallyl carbenoid, and addition of an aldehyde provides a rapid synthetic route to several linear terpenoid and terpene-polyketide natural products.
Dixon
Sally
S
School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK.
Gordon
George J
GJ
Whitby
Richard J
RJ