Effect of tryptophan depletion on symptoms of motion sickness in migraineurs.
Seven hours after 39 migraineurs and 37 controls consumed an amino acid drink that contained or omitted l-tryptophan (thereby reducing brain serotonin synthesis), motion sickness was provoked by the visual illusion of movement. Tryptophan depletion boosted dizziness, nausea, and the illusion of movement in controls to levels that approached those of migraineurs. Thus, reduced brain serotonin activity may promote vestibuloocular disturbances during motion sickness and attacks of migraine.
Drummond
Peter D
PD
School of Psychology, Murdoch University, Perth 6150, Western Australia. p.drummond@murdoch.edu.au
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D004311:Double-Blind Method; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007088:Illusions / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D009041:Motion Sickness / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D017120:Nystagmus, Optokinetic / Q000502:physiology; D010775:Photic Stimulation; D015990:Placebo Effect; D012701:Serotonin / Q000096:biosynthesis / Q000172:deficiency*; D016896:Treatment Outcome; D014364:Tryptophan / Q000097:blood / Q000172:deficiency* / Q000378:metabolism
D012701:Serotonin; D014364:Tryptophan