title: Carcinosarcoma of the extrahepatic bile duct.
abstract: A rare case of a carcinosarcoma of the extrahepatic bile duct demonstrating interesting features is described. A 75-year-old woman with a history of choledocholithotomy presented with acute obstructive suppurative cholangitis. Ultrasonography and computed tomography showed a thickened choledochal wall, with calcification. Percutaneous transhepatic and endoscopic retrograde cholangiography revealed a round filling defect accompanied by an irregular obstruction in the common bile duct. Carcinosarcoma was diagnosed from a protruding lesion in the common bile duct obtained by intraoperative frozen sectioning, and pylorus-preserving pancreatoduodenectomy was performed. Histological examination by light microscopy showed a transition between the carcinomatous and sarcomatous components and positive immunoreactivity for epithelial markers in the sarcomatous component. The patient died of a local recurrence 2 years after the surgery. Polypoid growth and ossification in the tumor could be representative features of carcinosarcoma of the extrahepatic bile duct.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kadono
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hamada
authors.forename: Michiyo
authors.initials: M
authors.lastname: Higashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishizaki
authors.forename: Noboru
authors.initials: N
authors.lastname: Nakamura
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Sakata
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology*; D017734:Bile Ducts, Extrahepatic; D002296:Carcinosarcoma / Q000473:pathology*; D002761:Cholangitis / Q000150:complications; D005260:Female; D006801:Humans; D016577:Pancreaticoduodenectomy