title: Cervical coinfection with human papillomavirus (HPV) types and possible implications for the prevention of cervical cancer by HPV vaccines.
abstract: Coinfection with multiple types of human papillomavirus (HPV) and its implications for the development of efficacious HPV vaccines is a subject of great interest. To describe the occurrence of concurrent infection with multiple HPV types and to determine whether genital HPV infection modifies the risk of acquiring a new HPV infection with another HPV type, 1610 subjects were monitored for an average of 4.1 years in Bogota, Colombia. Information on risk factors for HPV infection and cervical cells was collected for detection of HPV DNA of 36 types at study entry and at 6 consecutive 6-month follow-up visits. Clustering or the concurrent acquisition of multiple types occurred more often than would be expected by chance. Subjects with incident HPV-16 or -18 infection had 5-7 times higher odds of acquiring a subsequent HPV-58 infection than subjects not infected with HPV-16 or -18. This might affect the protection conferred by effective HPV vaccines.
authors.affiliation: Escuela de Salud Publica, Universidad del Valle, Cali, Colombia. famendez@univalle.edu.co
authors.forename: Fabian
authors.initials: F
authors.lastname: Mendez
authors.forename: Nubia
authors.initials: N
authors.lastname: Munoz
authors.forename: Hector
authors.initials: H
authors.lastname: Posso
authors.forename: Monica
authors.initials: M
authors.lastname: Molano
authors.forename: Victor
authors.initials: V
authors.lastname: Moreno
authors.forename: Adrian J C
authors.initials: AJ
authors.lastname: van den Brule
authors.forename: Margarita
authors.initials: M
authors.lastname: Ronderos
authors.forename: Chris
authors.initials: C
authors.lastname: Meijer
authors.forename: Alvaro
authors.initials: A
authors.lastname: Munoz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003105:Colombia; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D016017:Odds Ratio; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology*; D053918:Papillomavirus Vaccines; D012307:Risk Factors; D013045:Species Specificity; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D053918:Papillomavirus Vaccines; D014765:Viral Vaccines