title: Effectiveness of latanoprost (Xalatan) monotherapy in newly discovered and previously medicamentously treated primary open angle glaucoma patients.
abstract: We evaluated the effectiveness of latanoprost (Xalatan) monotherapy in primary open angle glaucoma (POAG). Latanoprost is a prostaglandin analogue, the pure 15(R) epimer of 13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2alpha-isopropyl ester. As a prodrug it is being activated by enzymatic hydrolysis in the cornea after which it becomes active acid of latanoprost. Latanoprost is lowering the intraocular pressure (IOP) by increasing the uveoscleral outflow. In this study, latanoprost was used once daily as monotherapy what offers much better compliance for the patients than other combinations of drugs, preserving good IOP control. Based on the significant reduction of the IOP, measured on the day 60 of the trial (mean change in IOP was -5.1 mmHg, with 95% confidence interval in range from -5.6 to -4.5), it is concluded that use of latanoprost is advisable when calculating better IOP control, few side-effects and reductions in costs of potential surgical procedures.
authors.affiliation: Department of Ophthalmology, Clinical Hospital Dubrava, Zagreb, Croatia.
authors.forename: Josip
authors.initials: J
authors.lastname: Pavan
authors.forename: Nikola
authors.initials: N
authors.lastname: Stambuk
authors.forename: Tihomir
authors.initials: T
authors.lastname: Curković
authors.forename: Pasko
authors.initials: P
authors.lastname: Konjevoda
authors.forename: Doroteja
authors.initials: D
authors.lastname: Pavan-Jukić
authors.forename: Marta
authors.initials: M
authors.lastname: Gotovac
authors.forename: Ksenija
authors.initials: K
authors.lastname: Karaman
mesh_terms: D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D018696:Neuroprotective Agents; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost