The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton.
Protein kinase CK2 is a highly conserved, pleiotropic, protein serine/threonine kinase that is essential for life in eukaryotes. CK2 has been implicated in diverse cellular processes such as cell cycle regulation, circadian rhythms, apoptosis, transformation and tumorigenesis. In addition, there is increasing evidence that CK2 is involved in the maintenance of cell morphology and cell polarity, and in the regulation of the actin and tubulin cytoskeletons. Accordingly, this review will highlight published evidence in experimental models ranging from yeast to mammals documenting the emerging roles of protein kinase CK2 in the regulation of cell polarity, cell morphology and the cytoskeleton.
Canton
David A
DA
Regulatory Biology and Functional Genomics Group, Siebens-Drake Medical Research Institute, Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.
Litchfield
David W
DW
D000199:Actins / Q000032:analysis / Q000502:physiology; D000818:Animals; D047390:Casein Kinase II / Q000235:genetics / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D048430:Cell Shape / Q000502:physiology*; D048429:Cell Size; D003599:Cytoskeleton / Q000737:chemistry / Q000502:physiology*; D005057:Eukaryotic Cells / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D007365:Intercellular Junctions / Q000502:physiology; D008870:Microtubules / Q000737:chemistry / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D012568:Schizosaccharomyces / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D014404:Tubulin / Q000032:analysis / Q000502:physiology
D000199:Actins; D014404:Tubulin; D011494:Protein Kinases; C034454:ectoprotein kinase; D047390:Casein Kinase II