title: [Effect of humectants on pharmaceutical availability and rheological properties of loratadine-containing hydrogels].
abstract: The paper examines the formulation of the antihistamine loratadine into hydrogels, the polymers under evaluation being Carbopol 980 and Vivastar P 5000. As other pharmaceutical auxiliary substances from the group of humectants are an indispensable component of hydrogels, the paper evaluates their influence (glycerol--GL, propylene glycol--PG, and sorbitol--SO) on the structural viscosity and pH of hydrogels as well as pharmaceutical availability of loratadine. On the basis of the results of the study it can be concluded that from the viewpoint of dermal administration of loratadine the hydrogels of the following composition are optimal: 0.5% Carbopol 980 + 5% SO and 1.5% Vivastar P 5000 + 5% PG.
authors.affiliation: Farmaceutická fakulta Univerzity Komenského v Bratislave. zajkoduracel@seznam.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Capková
authors.forename: Z
authors.initials: Z
authors.lastname: Vitková
authors.forename: V
authors.initials: V
authors.lastname: Vysokaiová
mesh_terms: D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D039563:Histamine H1 Antagonists, Non-Sedating / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D017336:Loratadine / Q000737:chemistry*; D010592:Pharmaceutic Aids; D012212:Rheology
chemical_list: D004337:Drug Carriers; D039563:Histamine H1 Antagonists, Non-Sedating; D020100:Hydrogels; D010592:Pharmaceutic Aids; D017336:Loratadine