title: Iminosugar-producing Thai medicinal plants.
abstract: Alpha-1-C-hydroxymethylfagomine (7), 3-O-beta-D-glucopyranosyl-DMDP (12), and 2,5-dideoxy-2,5-imino-D-glucitol (13) were isolated from the Thai traditional crude drug "Non tai yak" (Stemona tuberosa), which also contains a high concentration level of alpha-homonojirimycin (0.1% dry weight). "Thopthaep" (Connarus ferrugineus) and "Cha em thai" (Albizia myriophylla) contained 1-deoxymannojirimycin (DMJ) (10) at levels of 0.083% (dry weight) and 0.17% (dry weight), respectively. 2-O-alpha-D-Galactopyranosyl-DMJ (20), 3-O-beta-D-glucopyranosyl-DMJ (21), 1,4-dideoxymannojirimycin (17), 1,4-dideoxyallonojirimycin (18), and 1,4-dideoxyaltronojirimycin (19) from C. ferrugineus and 2-O-beta-D-glucopyranosyl-DMJ (22) and 4-O-beta-D-glucopyranosyl-DMJ (23) from A. myriophylla were isolated as new compounds.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan. n-asano@hokuriko-u.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Asano
authors.forename: Taku
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kagamifuchi
authors.forename: Naoko
authors.initials: N
authors.lastname: Shimizu
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takatsuka
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Kizu
authors.forename: Wongsatit
authors.initials: W
authors.lastname: Chuakul
authors.forename: Aikkarach
authors.initials: A
authors.lastname: Kettawan
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000606:Amino Sugars / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013785:Thailand
chemical_list: D000470:Alkaloids; D000606:Amino Sugars; D004791:Enzyme Inhibitors; D006026:Glycoside Hydrolases