Neuroprotection possibilities in epileptic children.
OBJECTIVE
The aim of this paper was to summarize of current knowledge about neuronal injuries during epileptogenesis process and possibilities of neuroprotection.


RESULTS
Many of agents from a wide range of classes have been proposed to possess neuroprotective potential, but especially in experimental and preclinical conditions. Among the antiepileptic drugs topiramate (TPM) and levetiracetam (LEV) possess neuroprotective effects in experimental models of brain damage. Promising protection against cell loss display antioxidants and neurotrophins.


CONCLUSIONS
Important and difficult problem of neuroprotective therapy in childhood epilepsy require further experimental and clinical investigations.
Artemowicz
B
B
Department of Pediatric Neurology and Rehabilitation Medical University of Białystok, Poland. kneur1@wp.pl
Sobaniec
W
W
D000927:Anticonvulsants / Q000627:therapeutic use*; D001927:Brain Diseases / Q000517:prevention & control; D002648:Child; D004827:Epilepsy / Q000188:drug therapy*; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D000077287:Levetiracetam; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077236:Topiramate
D000927:Anticonvulsants; D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose; D000077287:Levetiracetam; D010889:Piracetam