Botulinum toxin injections do not improve freezing of gait in Parkinson disease.
Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.
Wieler
Marguerite
M
Department of Medicine, University of Alberta, Edmonton, Canada. marguerite.wieler@ualberta.ca
Camicioli
Richard
R
Jones
C Allyson
CA
Martin
W R Wayne
WR
D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D018592:Cross-Over Studies; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D020233:Gait Disorders, Neurologic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D010919:Placebos; D011795:Surveys and Questionnaires; D017211:Treatment Failure
D010919:Placebos; D019274:Botulinum Toxins, Type A