title: Effect of serotonin on respiration, cerebral circulation, and blood pressure in rats.
abstract: The effects of intravenous serotonin on respiration, cerebral circulation, and blood pressure were examined in narcotized rats. Serotonin rapidly decreased local cerebral blood flow (by almost 30%) and blood pressure. Hemodynamic phenomena were accompanied by sharp changes in the respiration pattern: short-term apnea in all cases. The mechanism of this apnea was related to initial stages in blood pressure changes and had a neurogenic nature.
authors.affiliation: V. V. Zakusov State Research Institute of Pharmacology, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Aleksandrin
authors.forename: N N
authors.initials: NN
authors.lastname: Tarasova
authors.forename: I A
authors.initials: IA
authors.lastname: Tarakanov
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002540:Cerebral Cortex / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012701:Serotonin