title: Botulinum toxin injections do not improve freezing of gait in Parkinson disease.
abstract: Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Canada. marguerite.wieler@ualberta.ca
authors.forename: Marguerite
authors.initials: M
authors.lastname: Wieler
authors.forename: Richard
authors.initials: R
authors.lastname: Camicioli
authors.forename: C Allyson
authors.initials: CA
authors.lastname: Jones
authors.forename: W R Wayne
authors.initials: WR
authors.lastname: Martin
mesh_terms: D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D018592:Cross-Over Studies; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D020233:Gait Disorders, Neurologic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D010919:Placebos; D011795:Surveys and Questionnaires; D017211:Treatment Failure
chemical_list: D010919:Placebos; D019274:Botulinum Toxins, Type A