Allergic reaction to topical eyedrops.
OBJECTIVE
To examine recently published papers dealing with drug-induced allergic reactions. As allergy is only one possible mechanism, this review was extended to all reports or studies describing allergic, inflammatory or toxic effects related to eyedrops since 2004.


RESULTS
These studies were first classified into clinical reports or surveys, experimental works and biological studies showing drug-induced effects on the ocular surface or eyelids. Studies aimed at determining the role of preservatives or comparing preservative-free and preserved eyedrops were further analysed separately.


CONCLUSIONS
Reports on allergic or toxic reactions of eyedrops are published repeatedly. The reports raising the most important issues are those concerning antiglaucoma drugs. They consistently describe inflammatory reactions at the conjunctival level, with strong evidence that preservative is a major source of toxicity for the ocular surface.
Baudouin
Christophe
C
Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital, Paris, France. baudouin@quinze-vingts.fr
D000818:Animals; D003228:Conjunctiva / Q000187:drug effects; D003231:Conjunctivitis / Q000139:chemically induced; D003315:Cornea / Q000187:drug effects; D019557:Dermatitis, Perioral / Q000139:chemically induced; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects
D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical