title: Deep cavitands provide organized solvation of reactions.
abstract: Deep self-folding cavitands have been shown to stabilize the charged enolate intermediate of the alpha-deuteration of activated olefins by means of a network of organized solvation.
authors.affiliation: The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hooley
authors.forename: Julius
authors.initials: J
authors.lastname: Rebek
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000473:Alkanes / Q000737:chemistry*; D001665:Binding Sites; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry*; D006860:Hydrogen Bonding; D007097:Imines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012118:Resorcinols / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000179:Acrylates; D000473:Alkanes; D001643:Bridged Bicyclo Compounds; D004988:Ethers, Cyclic; D007097:Imines; D012118:Resorcinols; D012997:Solvents; C442939:cavitand; D003903:Deuterium; C017573:nonane; C035956:methyl acrylate