New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis.
Two new bisabolane-type sesquiterpenes, lippidulcine A (3) and epilippidulcine A (4), have been isolated from the aerial parts of Lippia dulcis TREV. along with five known flavonoids, cirsimaritin (5), salvigenin (6), eupatorin (7), 5-hydroxy-6,7,3',4'-tetramethoxyflavone (8) and 5,3'-dihydroxy-6,7,4',5'-tetramethoxyflavone (9), three known phenylethanoid glycosides, decaffeoylverbascoside (10), acteoside (11) and isoacteoside (12), and two known iridoid glucosides, 8-epiloganin (13) and lamiide (14). Their chemical structures have been determined on the basis of spectroscopic data. Among them, 5, 7, and 9 exhibited almost the same activity as that of alpha-tocopherol, and 10-12 were identified as stronger antioxidants than alpha-tocopherol using the ferric thiocyanate method.
Ono
Masateru
M
School of Agriculture, Kyushu Tokai University; 5435 Minamiaso, Aso, Kumamoto, Aso, Kumamoto 862-0973, Japan. mono@ktmail.ktkai-u.aac.jp
Morinaga
Hiroaki
H
Masuoka
Chikako
C
Ikeda
Tsuyoshi
T
Okawa
Masafumi
M
Kinjo
Junei
J
Nohara
Toshihiro
T
D000975:Antioxidants / Q000737:chemistry; D002236:Carbohydrate Conformation; D002851:Chromatography, High Pressure Liquid; D007501:Iron / Q000737:chemistry; D032411:Lippia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013861:Thiocyanates / Q000737:chemistry
D000975:Antioxidants; D010936:Plant Extracts; D012717:Sesquiterpenes; D013861:Thiocyanates; C505020:epilippidulcine A; C505017:lippidulcine A; C103724:ferric thiocyanate; D007501:Iron