Optical imaging in cat area 18: strabismus does not enhance the segregation of ocular dominance domains.
While early-onset strabismus leads to clearly segregated domains of the left and the right eye in cat primary visual cortex (area 17), far less is known about experience-dependent plasticity of ocular dominance in area 18. We therefore used optical imaging of intrinsic signals to analyze the influence of strabismus on cortical maps in cat area 18. Monocular visual stimulation of the left and right eye with moving square wave gratings of four different orientations induced patchy activity maps. Unlike our previous observations in cat area 17, the monocular activity maps in area 18 of strabismic cats were rather similar so that functional ocular dominance domains were not clearly segregated. Imaging of the 17/18 border region confirmed this observation and revealed a sudden change in the segregation of the left and right eye domains across the border. Our results demonstrate that modified visual input can have different consequences for different visual areas: while the decorrelation of activity between the two eyes (as induced by strabismus) clearly enhances the segregation of ocular dominance domains in cat area 17, area 18 does not show this effect although electrophysiological studies have confirmed that the percentage of binocularly driven neurons is as reduced as in area 17.
Schmidt
Karl-Friedrich
KF
Leibniz-Institute for Neurobiology, Project Group Visual Development and Plasticity, Brenneckestr. 6, D-39118 Magdeburg, Germany.
Löwel
Siegrid
S
D000818:Animals; D001931:Brain Mapping; D002415:Cats; D003627:Data Interpretation, Statistical; D023882:Dominance, Ocular / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D009473:Neuronal Plasticity / Q000502:physiology; D010775:Photic Stimulation; D013285:Strabismus / Q000503:physiopathology*; D015349:Vision, Monocular / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*