title: Synchronous liver resection and cryotherapy for colorectal metastases: survival analysis.
abstract: BACKGROUND
  The value of synchronous liver resection and cryotherapy ablation remains controversial for colorectal metastases where complete resection is not possible by conventional liver surgery alone.
  
  
  OBJECTIVE
  To review the long-term survival of patients treated using this approach at our institution.
  
  
  METHODS
  A review was undertaken of data held in the prospectively collected liver surgery database of all patients who underwent synchronous liver resection and cryotherapy. Survival analysis was performed and data recorded on the total number of metastases at initial surgery and the number of lesions treated by cryoablation.
  
  
  RESULTS
  Ninety-three patients with colorectal metastases underwent synchronous liver resection and cryotherapy. Data were available on 86 patients with a median follow-up of 18 months (range 1-83). The median number of metastases at initial surgery was four (range 2-11) and the number of lesions treated by cryotherapy ablation was two (range 1-8). Eighty-four per cent had a hepatic artery catheter inserted at surgery and at least one cycle of post-operative hepatic artery chemotherapy. One-, three- and five-year survival was 85%, 43% and 19% respectively, with a median survival of 33 months (95% confidence interval 19.9-42.1). Site of recurrence was recorded and presented.
  
  
  CONCLUSIONS
  Patients with liver metastases that are not amenable to resection alone can achieve worthwhile median survival with synchronous liver resection and cryotherapy ablation.
authors.affiliation: UNSW Department of Surgery St George Hospital, Sydney, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Brooks
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Alfredson
authors.forename: T D
authors.initials: TD
authors.lastname: Yan
authors.forename: D L
authors.initials: DL
authors.lastname: Morris
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D003452:Cryosurgery; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents