Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury.
OBJECTIVE
The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury.


METHODS
Thirty-nine patients with mild traumatic brain injury and 27 comparison subjects were genotyped. All subjects completed memory and attention tests, including the California Verbal Learning Test recognition task and the Continuous Performance Test.


RESULTS
In both groups the T allele was associated with poorer performance on the California Verbal Learning Test recognition task. There was also a significant diagnosis-by-allele interaction on measures of response latency (Continuous Performance Test): the subjects with mild traumatic brain injury and the T allele had the worst performance.


CONCLUSIONS
Genetic polymorphisms modulating central dopaminergic tone can affect cognitive outcome following mild traumatic brain injury.
McAllister
Thomas W
TW
Section of Neuropsychiatry, Department of Psychiatry, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756. thomas.w.mcallister@dartmouth.edu.
Rhodes
C Harker
CH
Flashman
Laura A
LA
McDonald
Brenna C
BC
Belloni
Dorothy
D
Saykin
Andrew J
AJ
D000328:Adult; D001288:Attention / Q000502:physiology; D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics* / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology
D017448:Receptors, Dopamine D2