Cyclosporin A aggravates electroshock-induced convulsions in mice with a transient middle cerebral artery occlusion.
1. To test whether an ischemic insult increases the susceptibility to cyclosporine A (CsA)-induced neurotoxicity, we examined the effect of CsA on the minimal electroshock-induced convulsions in mice treated with a transient middle cerebral artery occlusion (MCAO) for a short period (2 h). 2. This MCAO produced small to mid-sized infarcted regions in the cerebral hemisphere with increasing post-operative days. In MCAO mice, CsA (30 mg/kg, i.p.) elevated the incidence of minimal electroshock-induced convulsions to 90-100% over that in sham mice (20-30%) at 1-7 days but not 14 days post-surgery. 3. In light of these findings, the possibility that CsA increases the risk of convulsions in patients with cerebral infarction and/or at an early stage following focal cerebral ischemia would have to be considered.
Yamauchi
Atsushi
A
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Shuto
Hideki
H
Dohgu
Shinya
S
Nakano
Yoshitsugu
Y
Egawa
Takashi
T
Kataoka
Yasufumi
Y
D000818:Animals; D021461:Animals, Outbred Strains; D001812:Blood-Brain Barrier / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D004597:Electroshock; D004827:Epilepsy / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D012307:Risk Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine