title: Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats.
abstract: In this modern world, stress and pollution are unavoidable phenomena affecting the body system at various levels. A large number of people are exposed to potentially hazardous noise levels in daily modern life, such as noise from work environments, urban traffic, and household appliances. A variety of studies have suggested an association between noise exposure and the occurrence of disorders involving extra-auditory organs such as disorders of the nervous, endocrine, and cardiovascular systems. In this study, Wistar strain albino rats were subjected to 100 dB broadband white noise, 4 h daily for 15 days. The high-pressure liquid chromatographic estimation of norepinephrine, epinephrine, dopamine, and serotonin in discrete regions of the rat brain indicates that noise stress can alter the brain biogenic amines after 15 days of stress exposure. Ocimum sanctum (OS), a medicinal herb that is widely claimed to posses antistressor activity and used extensively in the Indian system of medicine for a variety of disorders, was chosen for this study. Administration of the 70% ethanolic extract of OS had a normalizing action on discrete regions of brain and controlled the alteration in neurotransmitter levels due to noise stress, emphasizing the antistressor potential of this plant.
authors.affiliation: Department of Physiology, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai - 600 113.
authors.forename: Rajan
authors.initials: R
authors.lastname: Ravindran
authors.forename: Sheela Devi
authors.initials: SD
authors.lastname: Rathinasamy
authors.forename: James
authors.initials: J
authors.lastname: Samson
authors.forename: Manohar
authors.initials: M
authors.lastname: Senthilvelan
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis; D004837:Epinephrine / Q000032:analysis; D008297:Male; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism; D009622:Noise / Q000009:adverse effects*; D009638:Norepinephrine / Q000032:analysis; D031339:Ocimum; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000032:analysis; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D018377:Neurotransmitter Agents; D010936:Plant Extracts; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine