title: Functional activity of antibodies after immunization of Finnish and Israeli infants with an 11-valent pneumococcal conjugate vaccine.
abstract: Finnish and Israeli infants received an 11-valent mixed carrier pneumococcal conjugate vaccine (11PCV) with or without aluminum adjuvant at the age of 2, 4, 6, and 12 months. We measured opsonophagocytic activity (OPA) of antibodies to pneumococcal strains of serotypes 4, 6B, 14, 19F, and 23F. At 7 months, OPA was clearly detected for all the serotypes. At 13 months, OPAs increased further and the proportion of individuals with a positive OPA ranged between 81 and 100%. The adjuvant improved functional activity of antibodies to serotype 6B pneumococci. In conclusion, immunization of infants with the 11PCV induced functionally active antibodies.
authors.affiliation: National Public Health Institute, Vaccine Immunology Laboratory, Mannerheimintie 166, 00300 Helsinki, Finland.
authors.forename: Tomi K
authors.initials: TK
authors.lastname: Wuorimaa
authors.forename: Ron
authors.initials: R
authors.lastname: Dagan
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bailleux
authors.forename: Raili
authors.initials: R
authors.lastname: Haikala
authors.forename: Nina
authors.initials: N
authors.lastname: Ekström
authors.forename: Juhani
authors.initials: J
authors.lastname: Eskola
authors.forename: Mansour
authors.initials: M
authors.lastname: Yaich
authors.forename: Helena
authors.initials: H
authors.lastname: Käyhty
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology*; D000915:Antibody Affinity; D005387:Finland; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007115:Immunization Schedule; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D007231:Infant, Newborn; D007557:Israel; D009895:Opsonin Proteins; D010587:Phagocytosis / Q000276:immunology; D022242:Pneumococcal Vaccines / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology; D018074:Vaccines, Conjugate / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D022242:Pneumococcal Vaccines; D011134:Polysaccharides; D018074:Vaccines, Conjugate; D000536:Aluminum Hydroxide