title: Primary immune deficiencies presenting in adults: seven years of experience from Iran.
abstract: Primary immunodeficiencies (PIDs) are not solely diseases of childhood. We describe the clinical presentation and outcome for 55 adult patients with previously unrecognized PIDs. This series provides unique data regarding PIDs presenting in adulthood, and serves as a timely reminder that physicians must consider the diagnosis of PIDs in their adult patients. Using the experience gained from these patients, we outline key "warning signs" suggestive of an underlying PID. Only through increased physician awareness will patients with PIDs receive timely diagnosis and optimal management.
authors.affiliation: National Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences, Darabad, Tehran, Iran. dmansouree@yahoo.com
authors.forename: Davood
authors.initials: D
authors.lastname: Mansouri
authors.forename: Parisa
authors.initials: P
authors.lastname: Adimi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mirsaedi
authors.forename: Nahal
authors.initials: N
authors.lastname: Mansouri
authors.forename: Payam
authors.initials: P
authors.lastname: Tabarsi
authors.forename: Majid
authors.initials: M
authors.lastname: Amiri
authors.forename: Hamid R
authors.initials: HR
authors.lastname: Jamaati
authors.forename: Masoud
authors.initials: M
authors.lastname: Motavasseli
authors.forename: Noushin
authors.initials: N
authors.lastname: Baghaii
authors.forename: Ali
authors.initials: A
authors.lastname: Cheraghvandi
authors.forename: Reza
authors.initials: R
authors.lastname: Rouhi
authors.forename: Navid A
authors.initials: NA
authors.lastname: Roozbahany
authors.forename: Soheila
authors.initials: S
authors.lastname: Zahirifard
authors.forename: Forouzan
authors.initials: F
authors.lastname: Mohammadi
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Masjedi
authors.forename: Ali A
authors.initials: AA
authors.lastname: Velayati
authors.forename: Jean L
authors.initials: JL
authors.lastname: Casanova
authors.forename: David P
authors.initials: DP
authors.lastname: Speert
authors.forename: R Kevin
authors.initials: RK
authors.lastname: Elwood
authors.forename: Robert
authors.initials: R
authors.lastname: Schellenberg
authors.forename: Stuart E
authors.initials: SE
authors.lastname: Turvey
mesh_terms: D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D000368:Aged; D001260:Ataxia Telangiectasia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology*; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency; D050718:Complement C1 Inhibitor Protein; D003937:Diagnosis, Differential; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics; D007136:Immunoglobulins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics; D007492:Iran; D007589:Job Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D012189:Retrospective Studies; D015843:Serpins / Q000172:deficiency; D014923:Wiskott-Aldrich Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology
chemical_list: D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; D007136:Immunoglobulins; C469952:SERPING1 protein, human; D015843:Serpins