title: Catheter directed thrombolysis for treatment of ilio-femoral deep venous thrombosis is durable, preserves venous valve function and may prevent chronic venous insufficiency.
abstract: OBJECTIVE
  To investigate the results of catheter directed thrombolysis offered to patients with acute femoro-iliac deep venous thrombosis (DVT).
  
  
  METHODS
  Retrospective analysis of all patients treated with this modality at Gentofte Hospital until December 2003.
  
  
  METHODS
  Forty-five consecutive patients treated between June 1999 and December 2003 with a median age of 31 years. All patients had femoro-iliac DVT with an average anamnesis of 6 days.
  
  
  METHODS
  All patients were treated by catheter directed infusion of alteplase into the popliteal vein. After thrombolysis residual venous stenoses were treated by percutaneous balloon angioplasty (PTA) and stenting. Patients were followed with color-duplex scanning for assessment of venous patency and reflux.
  
  
  RESULTS
  Forty-two of 45 (93%) of cases were treated successfully with reopening of the thrombosed vein segments. In 30 of 45 cases a residual stenosis was treated by PTA and stenting. Only one serious complication was observed: Compartment syndrome of the forearm where arterial punctures had been taken. After an average of 24 months follow-up were no cases of re-thrombosis among the 42 patients discharged with open veins. Only two of 41 with presumed normal venous valve function prior to DVT developed reflux during follow-up.
  
  
  CONCLUSIONS
  In this selected patient group, catheter directed thrombolysis seems effective in treating acute DVT, it appears durable and preserves venous valve function in the majority. The method needs to be tested in a randomised controlled trial.
authors.affiliation: Department of Vascular Surgery, Gentofte University Hospital, Hellerup, Denmark. henrik.sillesen@rh.dk
authors.forename: H
authors.initials: H
authors.lastname: Sillesen
authors.forename: S
authors.initials: S
authors.lastname: Just
authors.forename: M
authors.initials: M
authors.lastname: Jørgensen
authors.forename: N
authors.initials: N
authors.lastname: Baekgaard
mesh_terms: D000293:Adolescent; D000328:Adult; D000800:Angioplasty, Balloon; D002406:Catheterization, Peripheral; D003251:Constriction, Pathologic / Q000628:therapy; D005260:Female; D005268:Femoral Vein; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007084:Iliac Vein; D008297:Male; D008875:Middle Aged; D011152:Popliteal Vein; D012189:Retrospective Studies; D015607:Stents; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin; D010959:Tissue Plasminogen Activator