title: Histogenesis of intralesional fibrous septum in chordoma.
abstract: Intralesional fibrous septum (IFS), a histologic architecture that is typical of chordoma, consists of proliferating spindle-shaped, fibroblast-like cells with an abundance of collagen fibers. However, the histogenesis of IFS is still controversial. In a series of 122 chordomas, special emphasis was placed on the morphology of host tissues involved in IFS and on a transition between IFS and neighboring tissues. In 23 lesions, IFS was also characterized both histochemically and immunohistochemically. IFS was observed in 79 (64.8%) lesions. Occasionally, IFS contained bone fragments and hyalinized matrix with no lining of osteoblastic cells, suggesting degenerated rather than metaplastic bone tissue. Moreover, IFS occasionally showed a direct transition to host bone trabeculae. Histochemically and immunohistochemically, IFS included calcium deposits positive for Alizarin red S staining and expressed both type I and type III collagen. In extraosseous lesions extending to the adjacent soft tissues, IFS frequently involved muscle fibers or peripheral nerve fibers and displayed a smooth transition to neighboring soft tissues. We believe that IFS is induced by a tumor-host interaction that is based on the host bone trabeculae in intraosseous lesions or on soft tissues in extraosseous lesions.
authors.affiliation: Department of Pathology, Faculty of Medicine, Magdeburg University, Magdeburg, Germany. takahicom@hotmail.com
authors.forename: Takahiko
authors.initials: T
authors.lastname: Naka
authors.forename: Carsten
authors.initials: C
authors.lastname: Boltze
authors.forename: Doerthe
authors.initials: D
authors.lastname: Kuester
authors.forename: Amir
authors.initials: A
authors.lastname: Samii
authors.forename: Christian
authors.initials: C
authors.lastname: Herold
authors.forename: Helmut
authors.initials: H
authors.lastname: Ostertag
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Odae
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
authors.forename: Albert
authors.initials: A
authors.lastname: Roessner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000880:Anthraquinones; D002118:Calcium / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002817:Chordoma / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D004396:Coloring Agents; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D000880:Anthraquinones; D004396:Coloring Agents; C010078:alizarin; D003094:Collagen; D002118:Calcium