title: Drugging the undruggable.
abstract: In this issue of Chemistry and Biology, Li and Lawrence report an iterative synthesis/selection process to identify chemically modified peptide ligands possessing high affinity and selectivity for the SH3 domain of Fyn, a member of the Src kinase family.
authors.affiliation: Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. mayer_john_p@lilly.com
authors.forename: John P
authors.initials: JP
authors.lastname: Mayer
authors.forename: Richard D
authors.initials: RD
authors.lastname: Dimarchi
mesh_terms: D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D008024:Ligands; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D018909:src Homology Domains
chemical_list: D008024:Ligands; D010455:Peptides