Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.
The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant HIV-1-specific CTL can select for viral escape variants very early in life. These variants, furthermore, may be selected specifically in the infant, despite the same CTL specificity being present in the mother. Additionally, pediatric CTL activity may be compromised both by the transmission of maternal escape variants and by mother-to-child transmission of escape variants that originally arose in the father. The unique acquisition of these CTL escape forms may help to explain the severe nature of some pediatric HIV infections.
Pillay
Thillagavathie
T
The Peter Medawar Building for Pathogen Research and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom.
Zhang
Hua-Tang
HT
Drijfhout
Jan W
JW
Robinson
Nicola
N
Brown
Helen
H
Khan
Munira
M
Moodley
Jagadesa
J
Adhikari
Miriam
M
Pfafferott
Katja
K
Feeney
Margaret E
ME
St John
Anne
A
Holmes
Edward C
EC
Coovadia
Hoosen M
HM
Klenerman
Paul
P
Goulder
Philip J R
PJ
Phillips
Rodney E
RE
D000595:Amino Acid Sequence; D000939:Epitopes / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D015488:HIV Antigens / Q000235:genetics; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000276:immunology* / Q000472:pathogenicity; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D011247:Pregnancy; D012641:Selection, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000821:virology*
D000939:Epitopes; D015488:HIV Antigens; D015235:HLA-B Antigens