Animal models of pulmonary fibrosis.
In general, there are two types of animal models: natural and experimental. Because there are no natural models for pulmonary fibrosis, an experimental model that reproduces key aspects of the human disease would be useful for the study of this form of lung disease, the natural history of which is not always known. To date, a variety of animal models have been used to investigate mechanisms of pulmonary and other types of fibrosis, including the intratracheal instillation of bleomycin, fluorescein isothiocyanate, or particulate matter, such as silica and asbestos. This chapter will describe two commonly used techniques, namely bleomycin and silica-induced, which have been developed for the study of pulmonary fibrosis in animal models.
Gharaee-Kermani
Mehrnaz
M
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Ullenbruch
Matthew
M
Phan
Sem H
SH
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D001194:Asbestos / Q000633:toxicity*; D001761:Bleomycin / Q000633:toxicity*; D004195:Disease Models, Animal; D016650:Fluorescein-5-isothiocyanate / Q000633:toxicity*; D005456:Fluorescent Dyes / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344; D012822:Silicon Dioxide / Q000633:toxicity*
D000777:Anesthetics; D000903:Antibiotics, Antineoplastic; D005456:Fluorescent Dyes; D001761:Bleomycin; D001194:Asbestos; D012822:Silicon Dioxide; D016650:Fluorescein-5-isothiocyanate