title: Evolution of individual renal function in children with unilateral complex renal duplication.
abstract: OBJECTIVE
  To assess the evolution of individual renal function during the maturation process in terms of single kidney glomerular filtration rate (SKGFR) and split function in children with unilateral complex renal duplication.
  
  
  METHODS
  We retrospectively reviewed the records of 44 children with unilateral complex duplex kidney. All affected kidneys had a poor or nonfunctioning dysplastic moiety, 28 in the upper pole and 16 in the lower pole. At least 2 radioisotopic examinations, including a 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renogram and a plasma clearance of 51Cr-ethylenediaminetetraacetic acid (Cr-51 EDTA), were performed in all children, the first one performed at a median age of 3 months (range 2 to 15 months) and the last one at 24 months (range 12 to 120 months). They allowed a precise estimation of split renal function, overall glomerular filtration rate (GFR), and SKGFR.
  
  
  RESULTS
  Mean overall kidney GFR increased significantly between the two measurements from 63 +/- 12.7 mL/minute/1.73 m2 to 95 +/- 21 mL/minute/1.73 m2 (P <.0001). SKGFR of the duplex side similarly increased from 26 +/- 7.7 mL/minute/1.73 m2 to 38 +/- 12.6 mL/minute/1.73 m2 (P <.0001). In terms of split function, the affected kidney had a remarkable stable function between the two measurements, 40% +/- 8.6 and 39% +/- 8.3 (P=.94), respectively. However, cases with the lowest initial split function (<30%) had the lowest initial SKGFR and the worst further evolution.
  
  
  CONCLUSIONS
  In children with unilateral complex renal duplication, we found on the affected side a significant increase of SKGFR because of renal maturation, whereas mean split function remained stable during follow-up.
authors.affiliation: Department of Perinatal and Pediatric Nephrology, Hôpital Universitaire des Enfants-Reine Fabiola and Hôpital Erasme, Brussels, Belgium. kismaili@yucom.be
authors.forename: Khalid
authors.initials: K
authors.lastname: Ismaili
authors.forename: Michelle
authors.initials: M
authors.lastname: Hall
authors.forename: Hamphrey
authors.initials: H
authors.lastname: Ham
authors.forename: Amy
authors.initials: A
authors.lastname: Piepsz
mesh_terms: D004492:Edetic Acid / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008499:Medical Records; D008657:Metabolic Clearance Rate; D011877:Radionuclide Imaging; D012042:Registries; D012189:Retrospective Studies
chemical_list: D004492:Edetic Acid