Chemokinetics.
How do migrating neural progenitor cells and growing axons know where to go? In this issue of Neuron, two papers (Knaut et al. and Lieberam et al.) demonstrate that activation of Cxcr4 chemokine receptors by the chemokine SDF1/Cxcl12 can direct both of these tasks.
Miller
Richard J
RJ
Dept of Molecular Pharmacology and Biological Chemistry, Northwestern Univeristy Feinberg Schoole of Medicine, 300 East Chicago Avenue, Chicago, Illinois 60611, USA.
Tran
Phuong B
PB
D000818:Animals; D001369:Axons / Q000502:physiology; D002465:Cell Movement; D054377:Chemokine CXCL12; D018925:Chemokines / Q000502:physiology*; D019743:Chemokines, CXC / Q000502:physiology*; D051379:Mice; D009046:Motor Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology; D012668:Trigeminal Ganglion / Q000166:cytology / Q000196:embryology / Q000502:physiology; D015027:Zebrafish
D054377:Chemokine CXCL12; D018925:Chemokines; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D019718:Receptors, CXCR4