title: Application of MVBC equation to predict mixed venous blood concentrations of sevoflurane in cardiac anaesthesia.
abstract: We have proposed an equation for estimating the real-time mixed venous blood concentration (MVBC) of isoflurane in cardiac anaesthesia. However, information related to the application of our method to sevoflurane is lacking. We studied 12 patients undergoing cardiac surgery and anaesthetised with sevoflurane. At different time points, pulmonary arterial blood samples were collected for gas chromatography-mass spectrometry (GC-MS) to determine the real mixed venous concentrations of sevoflurane. The inspired and expired concentrations of sevoflurane, measured by a gas monitor, were used for the MVBC calculations. Using Bland-Altman analyses, we found that the calculated MVBCs accurately represent the actual concentrations of sevoflurane in pulmonary arterial blood, as shown by a near-zero percentage bias with a 0.14% precision between the two concentrations. The results demonstrated that our equation could be a useful method for estimating the pulmonary blood concentration of sevoflurane.
authors.affiliation: Department of Anaesthesia, Taichung Veterans General Hospital and Chung Shan Medical University, Taichung, Taiwan. wmho@vght.gov.tw
authors.forename: W-M
authors.initials: WM
authors.lastname: Ho
authors.forename: W T
authors.initials: WT
authors.lastname: Hung
authors.forename: C C
authors.initials: CC
authors.lastname: Wu
authors.forename: C H
authors.initials: CH
authors.lastname: Shen
authors.forename: N C
authors.initials: NC
authors.lastname: Yang
authors.forename: K L
authors.initials: KL
authors.lastname: Hwang
authors.forename: K C
authors.initials: KC
authors.lastname: Wong
mesh_terms: D000368:Aged; D000465:Algorithms; D000769:Anesthesia, Inhalation / Q000379:methods; D018685:Anesthetics, Inhalation / Q000097:blood*; D000886:Anthropometry; D006348:Cardiac Surgical Procedures; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D011651:Pulmonary Artery; D015203:Reproducibility of Results; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane