title: Coelomic fluid leptin concentration in normal first-trimester pregnancies and missed miscarriages.
abstract: OBJECTIVE
  Investigation of the possible role of leptin in early pregnancy failure.
  
  
  METHODS
  Leptin concentration was measured in maternal serum, coelomic fluid and amniotic fluid from 15 singleton pregnancies with live fetuses and 7 missed miscarriages at 7-10 weeks of gestation.
  
  
  RESULTS
  In the pregnancies with live fetuses, the median leptin concentration was significantly higher in coelomic fluid (median 33.1 ng/ml) than in maternal serum (median 8.1 ng/ml) or amniotic fluid (median 0.5 ng/ml). In the pregnancies with missed miscarriage, compared to those with live fetuses, the median leptin concentration in coelomic fluid was higher (median 45.3 ng/ml), but in maternal serum it was not significantly different (median 5.5 ng/ml).
  
  
  CONCLUSIONS
  The high coelomic fluid leptin concentration suggests that embryonic death may be preceded by impaired oxygenation of the placenta that stimulates production of leptin.
authors.affiliation: Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece. grmak@otenet.gr
authors.forename: G
authors.initials: G
authors.lastname: Makrydimas
authors.forename: H
authors.initials: H
authors.lastname: Vandecruys
authors.forename: A
authors.initials: A
authors.lastname: Sotiriadis
authors.forename: L
authors.initials: L
authors.lastname: Lakasing
authors.forename: K
authors.initials: K
authors.lastname: Spencer
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000030:Abortion, Missed / Q000378:metabolism*; D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D005313:Fetal Death / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism*
chemical_list: D020738:Leptin; D010100:Oxygen