title: Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.
abstract: The vesicular monoamine transporter (VMAT2) is important in the storage and release of monoamines. Platelet VMAT2 was characterized using high-affinity [(3)H]dihydrotetrabenazine ([(3)H]TBZOH) binding in untreated social phobia (SP) patients (n=20) compared with sex- and age-matched healthy controls (n=15). No significant differences in VMAT2 density (B(max)) and affinity constants (K(d)) were observed.
authors.affiliation: Geha Psychiatric Hospital and Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Neil
authors.initials: N
authors.lastname: Laufer
authors.forename: Michal
authors.initials: M
authors.lastname: Zucker
authors.forename: Haggai
authors.initials: H
authors.lastname: Hermesh
authors.forename: Sofi
authors.initials: S
authors.lastname: Marom
authors.forename: Royi
authors.initials: R
authors.lastname: Gilad
authors.forename: Vered
authors.initials: V
authors.lastname: Nir
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.forename: Moshe
authors.initials: M
authors.lastname: Rehavi
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D002452:Cell Count; D005260:Female; D006801:Humans; D008297:Male; D010698:Phobic Disorders / Q000175:diagnosis* / Q000378:metabolism*; D011795:Surveys and Questionnaires; D013747:Tetrabenazine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D050493:Vesicular Monoamine Transport Proteins / Q000097:blood* / Q000378:metabolism
chemical_list: C493452:SLC18A2 protein, human; D050493:Vesicular Monoamine Transport Proteins; C032811:dihydrotetrabenazine; D013747:Tetrabenazine