Mechanism of the effect of postresuscitation changes in the brain on the dynamics of extinction of orientation and exploratory response in rats.
The type of open-field behavior (determined in preliminary tests) was preserved after 10-min circulatory arrest. Postresuscitation changes in the bran modified orientation and exploratory activity under conditions of its partial extinction before clinical death. High behavioral activity of rats in the first open-field session after resuscitation was related to the impairment of memory traces, while that in the follow-up period was associated with the formation of a pathological self-maintaining system between components of orientation and exploratory behavior.
Zarzhetskii
Yu V
YV
Institute of General Reanimatology, Russian Academy of Medical Sciences. niiorramo@medann.ru
Volkov
A V
AV
Khitrov
N K
NK
Moroz
V V
VV
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology; D005106:Exploratory Behavior; D008297:Male; D051381:Rats; D012151:Resuscitation