title: Antioxidant activity of ethanol extract of Callophyllis japonica.
abstract: The antioxidant properties of the red seaweed Callophyllis japonica were investigated. An ethanol extract isolated from C. japonica exhibited intracellular reactive oxygen species, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and lipid peroxidation inhibitory activity. The radical scavenging activity of the extract protected the viability of Chinese hamster lung fibroblast (V79-4) cells exposed to H2O2. Furthermore, the extract reduced the proportion of apoptotic cells induced by H2O2, as demonstrated by decreased sub-G1 hypo-diploid cells and decreased apoptotic body formation. The extract also increased the activities of the cellular antioxidant enzymes, superoxide dismutase and catalase. Together, these findings suggest that C. japonica exhibits antioxidant properties.
authors.affiliation: Department of Biochemistry, College of Medicine, Cheju National University, Jeju, 690-756 South Korea.
authors.forename: Kyoung Ah
authors.initials: KA
authors.lastname: Kang
authors.forename: Hyung Deuk
authors.initials: HD
authors.lastname: Bu
authors.forename: Dal Soo
authors.initials: DS
authors.lastname: Park
authors.forename: Gyung Min
authors.initials: GM
authors.lastname: Go
authors.forename: Youngheun
authors.initials: Y
authors.lastname: Jee
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D005434:Flow Cytometry; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006861:Hydrogen Peroxide / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects*; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012624:Seaweed
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl