Immunocorrection of alcohol dependence by immunization with a serotonin-homologous protein carrier conjugate.
We demonstrated a possibility of inducing antibody production against serotonin in high titers in rats by active immunization with serotonin conjugated with a homologous protein carrier (rat serum albumin) and with a foreign protein carrier (BSA).
Evseev
V A
VA
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Vetrile
L A
LA
Fomina
V G
VG
Trekova
N A
NA
D000428:Alcohol Drinking / Q000188:drug therapy* / Q000276:immunology; D000437:Alcoholism / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000097:blood; D000431:Ethanol / Q000008:administration & dosage; D016233:Immunotherapy, Active; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000031:analogs & derivatives* / Q000276:immunology* / Q000627:therapeutic use; D012709:Serum Albumin / Q000276:immunology / Q000627:therapeutic use*; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000627:therapeutic use*
D000906:Antibodies; D012709:Serum Albumin; C101227:serotonin-BSA conjugate; C504811:serotonin-rat serum albumin conjugate; D012710:Serum Albumin, Bovine; D012701:Serotonin; D000431:Ethanol