title: [Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model].
abstract: In this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.
authors.affiliation: Orthopädische Klinik II im Annastift, Medizinische Hochschule, Hannover. thorey@annastift.de
authors.forename: F
authors.initials: F
authors.lastname: Thorey
authors.forename: F
authors.initials: F
authors.lastname: Witte
authors.forename: J
authors.initials: J
authors.lastname: Nellesen
authors.forename: N
authors.initials: N
authors.lastname: Griep-Raming
authors.forename: H
authors.initials: H
authors.lastname: Menzel
authors.forename: G
authors.initials: G
authors.lastname: Gross
authors.forename: A
authors.initials: A
authors.lastname: Hoffmann
authors.forename: J
authors.initials: J
authors.lastname: Seufert
authors.forename: H
authors.initials: H
authors.lastname: Windhagen
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D005269:Femur / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D008422:Materials Testing; D016348:Osseointegration / Q000187:drug effects*; D010865:Pilot Projects; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D016212:Transforming Growth Factor beta / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D016212:Transforming Growth Factor beta; D014025:Titanium