title: [Correlation between the polymorphism of HLA-A, -B, and -DRB1 alleles and susceptibility to leukemia].
abstract: OBJECTIVE
  To explore the correlation between the polymorphism of HLA-A, -B and -DRB1 alleles and susceptibility to leukemia in Chinese Han population, Gansu province.
  
  
  METHODS
  The polymorphism of HLA-A, -B and -DRB1 alleles in 57 patients with leukemia and 45 normal controls were determined by PCR with sequence-specific oligonucleotide probe (PCR-SSO).
  
  
  RESULTS
  The frequencies of allele HLA-A01, -B38, and -DR15 in patients with leukemia were higher than those in control group (P<0.05), while the frequencies of allele HLA-A11 and -DR03 notably decreased (P<0.05).
  
  
  CONCLUSIONS
  HLA-A01, -B38 and -DR15 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia.
authors.affiliation: Center Laboratory, First Hospital of Lanzhou University, Lanzhou 730000, China. lanxiazhou@hotmail.com
authors.forename: Lan-xia
authors.initials: LX
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains