Prognostic value of electrocorticography findings during callosotomy in children with Lennox-Gastaut syndrome.
OBJECTIVE
To analyze findings and acute changes in electrocorticograms (ECoGs) obtained during corpus callosotomy in order to identify any relationships with the postoperative outcome of seizure activity.


METHODS
We retrospectively analyzed ECoGs obtained during anterior callosotomy (4-6 cm) in 48 patients with Lennox-Gastaut syndrome (32 boys and 16 girls, age 1-20 years, mean age 7.6 years) who underwent surgery between July 1993 and November 1996 to correlate recording findings with postoperative seizure activity. At the time of analysis, all patients had been followed postoperatively for more than 4 years.


RESULTS
Of 48 patients, 31 (64.6%) had significant improvement in seizure control after surgery. In pre-excisional ECoGs, 38 (79.2%) of 48 patients had bisynchronous epileptiform discharges. Patients (23 of 33 patients, 69.7%) with significant blockage of bisynchronous discharges recorded during callosotomy achieved the best postoperative seizure outcomes, but the difference did not reach statistical significance (P>0.05).


CONCLUSIONS
Based on our experience, changes in ECoG during callosotomy do not predict postoperative seizure outcome. Insignificant blockage of bisynchronous epileptiform discharges in ECoGs during callosotomy does not predict a worse prognosis than that associated with significant intraoperative blockage.
Kwan
Shang-Yeong
SY
Pediatric Epilepsy Surgery Group, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Lin
Ji-Ho
JH
Wong
Tai-Tong
TT
Chang
Kai-Ping
KP
Yiu
Chun-Hing
CH
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D011184:Postoperative Period; D011379:Prognosis; D011612:Psychosurgery / Q000379:methods; D012189:Retrospective Studies; D012640:Seizures / Q000503:physiopathology; D016896:Treatment Outcome