A mechanistic model for quasistatic pulmonary pressure-volume curves for inflation.
A mechanistic model of the respiratory system is proposed to understand differences in quasistatic pressure-volume (p-V) curves of the inflation process in terms of the alveolar recruitment and the elastic distension of the wall tissues. In the model, a total respiratory system consists of a large number of elements, each of which is a subsystem of a cylindrical chamber fitted with a piston attached to a spring. The alveolar recruitment is simulated by allowing a distribution of the critical pressure at which an element opens; while the wall distension is represented by the piston displacement. Relations are derived between parameters in the error-function p-V model equation and properties of the mechanistic model The parameters of the model-based p-V equation are determined for clinical data sets of patients with acute respiratory distress syndrome.
Amini
R
R
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, USA.
Creeden
K
K
Narusawa
U
U
D000403:Airway Resistance / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D001239:Inhalation; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008954:Models, Biological; D011312:Pressure; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D013314:Stress, Mechanical; D013990:Tidal Volume