[Levofloxacin (oftaquix) a fluoroquinolone of a new generation in prevention of the postoperative endophthalmitis following uncomplicated cataract surgery--the study of the European Society of Cataract and Refractive Surgeons (ESCRS)].
Randomised multi-centre european clinical trial of antibiotic prophylaxis for endophthalmitis following cataract surgery - study has just begun in Poland. Poland is joining one of the largest prospective european clinical study of antibiotic prophylaxis and the largest in ophthalmology - the ESCRS endophthalmitis prophylaxis clinical trial. Up to 35 000 cataract patients are going to be recruited for this randomized, controlled, multi-centre study in 16 centres from 10 european countries. The goal is to reduce the incidence of endophthalmitis after cataract phacoemusification in Europe to less than 0.05% (less than 1 per 2 000 surgeries). The patients will be divided into four groups; different regimes of two antibiotics: cefuroxime injected intra-camerally and levofloxacine eye drops topically will be compared.
Izdebska
Justyna
J
Z Katedry i Kliniki Okulistyki II Wydziału Lekarskiego Akademii Medycznej w Warszawie.
Szaflik
Jacek P
JP
D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002444:Cefuroxime / Q000008:administration & dosage*; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control*; D005060:Europe; D006801:Humans; D007267:Injections; D064704:Levofloxacin; D015337:Multicenter Studies as Topic; D015242:Ofloxacin / Q000008:administration & dosage*; D018918:Phacoemulsification / Q000009:adverse effects*; D011044:Poland; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin; D002444:Cefuroxime