Germline variations of the topoisomerase IIalpha gene as risk factors for primary gastric B-cell lymphoma.
We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronic Helicobacter pylori infection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.05). No genetic variations in the promotor region were found in 92 chromosomes of lymphoma patients and controls and linkage disequilibrium indicated a highly conserved genomic region. The results of our work exclude genetic variations as predisposing factors of primary gastric B-cell lymphoma development.
Hellmig
Stephan
S
Department of General Internal Medicine, University Hospital of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. s.hellmig@mucosa.de
Gieseler
Frank
F
Ott
Stephan
S
Rosenstiel
Phillip
P
Fischbach
Wolfgang
W
Fölsch
Ulrich Robert
UR
Schreiber
Stefan
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D018095:Germ-Line Mutation; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000235:genetics*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics*
D000951:Antigens, Neoplasm; D004268:DNA-Binding Proteins; D004250:DNA Topoisomerases, Type II