title: Effect of colony-stimulating factor and conventional- or high-dose chemotherapy on FDG uptake in bone marrow.
abstract: OBJECTIVE
  Granulocyte or granulocyte-macrophage colony stimulating factor (CSF), usually used in conjunction with chemotherapy, may interfere with the( 18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) reading. The purpose of this study is to evaluate the effects of CSF, conventional-or high-dose chemotherapy on bone marrow FDG uptake.
  
  
  METHODS
  Two hundred and forty-one FDG PET scans obtained in 163 patients with lymphoma and no pathologically and radiologically proven bone marrow involvement were analyzed. The standardized uptake value (SUV) of each patient's spine was measured.
  
  
  RESULTS
  Among patients with no recent history of CSF use, the average SUV in 36 patients with no history of chemotherapy was 1.60+/-0.34, that in 49 patients with a history of conventional-dose chemotherapy was 1.37+/-0.32, and that in 12 patients with a history of high-dose chemotherapy was 1.26+/-0.25 (P=0.008 and 0.002, respectively by Mann-Whitney U test). In 80 patients treated with conventional-dose chemotherapy and CSF, the average SUV after discontinuation of CSF was as follows: 0-7 days, 2.37+/-1.19; 8-14 days: 2.04+/-0.67; 15-21 days: 1.87+/-0.52; 22-30 days: 1.59+/-0.18; 31-90 days: 1.54+/-0.36. In 45 patients treated with high-dose chemotherapy and CSF, no significant increase in bone marrow uptake was seen in most of them.
  
  
  CONCLUSIONS
  Bone marrow FDG uptake may be increased by CSF treatment and may be decreased by chemotherapy. In patients treated with conventional-dose chemotherapy and CSF, increased marrow uptake will return to the pretreatment value approximately 1 month after discontinuation of CSF.
authors.affiliation: Division of Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. kazamat@fg7.so-net.ne.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kazama
authors.forename: Nancy
authors.initials: N
authors.lastname: Swanston
authors.forename: Donald A
authors.initials: DA
authors.lastname: Podoloff
authors.forename: Homer A
authors.initials: HA
authors.lastname: Macapinlac
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D003115:Colony-Stimulating Factors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000528:radiation effects; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D003115:Colony-Stimulating Factors; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D016178:Granulocyte-Macrophage Colony-Stimulating Factor