title: Effect of hydroxyapatite-coated tibial components on changes in bone mineral density of the proximal tibia after uncemented total knee arthroplasty: a prospective randomized study using dual-energy x-ray absorptiometry.
abstract: Sixteen patients scheduled for an uncemented total knee arthroplasty (TKA) were randomized to receive a tibial component either with (n = 8) or without (n = 8) hydroxyapatite (HA) coating. In 4 regions of interest, prospective measurements of bone mineral density (BMD) using dual-energy x-ray absorptiometry were performed in the proximal tibia. Two years after the operation, the only significant change in BMD was in the lateral tibial condyle, where BMD had increased by 6.1% (95% confidence interval: 2.3%-9.9%) in patients with tibial components without HA. The intragroup changes (0-24 months) in the uncoated group and HA-coated group were significantly different (P = .003) in these regions of interest. There was no significant effect of HA coating on bone remodeling pattern of the proximal tibia.
authors.affiliation: Department of Orthopedics, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Petersen
authors.forename: P Martin
authors.initials: PM
authors.lastname: Gehrchen
authors.forename: Svend E
authors.initials: SE
authors.lastname: Ostgaard
authors.forename: Palle K
authors.initials: PK
authors.lastname: Nielsen
authors.forename: Bjarne
authors.initials: B
authors.lastname: Lund
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D015519:Bone Density; D017886:Durapatite; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011474:Prosthesis Design; D013977:Tibia
chemical_list: D017886:Durapatite