Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis.
OBJECTIVE
To clarify the clinical significance of serum levels of pulmonary and activation-regulated chemokine (PARC) in the diagnosis and monitoring of pulmonary fibrosis (PF) in patients with systemic sclerosis (SSc) and to compare PARC levels with KL-6 antigen or surfactant protein D (SP-D) levels.


METHODS
Serum PARC levels were determined by enzyme-linked immunosorbent assay in 123 SSc patients. In a retrospective longitudinal study, correlation of serum PARC levels with the activity of PF was assessed in 21 SSc patients with active PF.


RESULTS
PARC levels at the first visit were higher in patients with SSc than in patients with systemic lupus erythematosus (SLE) or healthy controls. Increased serum PARC levels were associated with involvement of PF, decreased diffusing capacity for carbon monoxide, and decreased vital capacity in SSc patients. In the longitudinal study, serum PARC levels were significantly decreased in SSc patients with inactive PF compared with those with active PF.


CONCLUSIONS
Elevated serum PARC levels correlated with PF and more sensitively reflected the PF activity than did serum KL-6 or SP-D levels in SSc. Serum PARC levels may be a useful new serum marker for active PF in SSc.
Kodera
Masanari
M
Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Hasegawa
Minoru
M
Komura
Kazuhiro
K
Yanaba
Koichi
K
Takehara
Kazuhiko
K
Sato
Shinichi
S
D000941:Antigens / Q000097:blood; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D019742:Chemokines, CC / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000097:blood; D011658:Pulmonary Fibrosis / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood; D045743:Scleroderma, Diffuse / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D045745:Scleroderma, Limited / Q000097:blood* / Q000150:complications / Q000175:diagnosis
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; C111792:CCL18 protein, human; D019742:Chemokines, CC; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D