title: [Progress in study of ADAM33 gene].
abstract: A disintegin and metalloprotease-encoding gene (ADAM) 33, located on the short arm of chromosome 20 (20p13), was recently identified through a genome-wide scan for asthma. It is a new member of a family of genes encoding a group of the metalloproteinase superfamily called the ADAM family. The proteolytic activity of the ADAMs plays important role in the healthy and disease states. The identification of ADAM33 as a candidate gene for asthma may provide a newly therapeutic target for this disease.
authors.affiliation: Laboratory of Pulmonary Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. zhiguang_su@hotmail.com
authors.forename: Zhi-Guang
authors.initials: ZG
authors.lastname: Su
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Wen
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
mesh_terms: D051722:ADAM Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D001249:Asthma / Q000235:genetics* / Q000378:metabolism; D016535:Bronchial Hyperreactivity / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human