Neuroprotective and antioxidant activity of compounds from the aerial parts of Dioscorea opposita.
Bioactivity-guided fractionation of an ethanol extract of the aerial parts of Dioscorea opposita afforded a new compound, 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (1), and four known compounds, chrysoeriol 4'-O-beta-D-glucopyranoside (2), chrysoeriol 7-O-beta-D-glucopyranoside (3), alternanthin (4), and daucosterol. The structure of 1 was established on the basis of the interpretation of its 1D and 2D NMR spectrascopic data. Compounds 1-4 exhibited both promising neuroprotective effects and discernible to moderate antioxidant activities in vitro.
Ma
Chao
C
Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People's Republic of China.
Wang
Wei
W
Chen
Yun-Yun
YY
Liu
Rui-Ning
RN
Wang
Ru-Feng
RF
Du
Li-Jun
LJ
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027742:Dioscorea / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
C504635:6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D010616:Phenanthrenes