title: Effects of an aqueous extract of Puerariae flos (Thomsonide) on impairment of passive avoidance behavior in mice.
abstract: The effects of an aqueous extract of Puerariae flos (Thomsonide) on ethanol-induced learning and memory impairment and scopolamine-induced amnesia were investigated. Thomsonide exerted an ameliorating effect on the impairment of both memory registration and memory retrieval induced by ethanol. These results indicate that Thomsonide has an antiamnesic effect on the central nervous system in alcoholic intoxication and support the traditional use of Puerariae flos for the treatment of alcoholic intoxication. Thomsonide also improved the scopolamine-induced impairment of memory registration in passive avoidance behavior in mice. The results of this study suggest that it may be possible to use Thomsonide for the treatment of age-related memory impairment and dementia.
authors.affiliation: Tsukuba Research Institute, Ohat's Isan Co. Ltd., Ushiku, Ibaraki 300-1231, Japan. t_yamazaki@ohta-isan.co.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Masako
authors.initials: M
authors.lastname: Yaguchi
authors.forename: Yoshijiro
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hosono
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Niiho
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Hibi
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors / Q000633:toxicity; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D018727:Muscarinic Antagonists / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D029908:Pueraria / Q000737:chemistry*; D012601:Scopolamine / Q000037:antagonists & inhibitors / Q000633:toxicity
chemical_list: D002492:Central Nervous System Depressants; D018727:Muscarinic Antagonists; D010936:Plant Extracts; C505747:Thomsonide; D000431:Ethanol; D012601:Scopolamine