title: Trophoblast invasion and placentation: molecular mechanisms and regulation.
abstract: Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed.
authors.affiliation: Laboratory of Tumor Biology and Development, Pathology B23, CHU Liège, Liège, Belgium.
authors.forename: Frédéric
authors.initials: F
authors.lastname: van den Brûle
authors.forename: Sarah
authors.initials: S
authors.lastname: Berndt
authors.forename: Nadine
authors.initials: N
authors.lastname: Simon
authors.forename: Capucine
authors.initials: C
authors.lastname: Coulon
authors.forename: Jeanne
authors.initials: J
authors.lastname: Le Goarant
authors.forename: Carine
authors.initials: C
authors.lastname: Munaut
authors.forename: Agnès
authors.initials: A
authors.lastname: Noël
authors.forename: Francis
authors.initials: F
authors.lastname: Frankenne
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002465:Cell Movement; D005260:Female; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism; D010929:Placentation / Q000502:physiology*; D011225:Pre-Eclampsia / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D010447:Peptide Hydrolases