title: Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population.
abstract: OBJECTIVE
  Adiponectin, resistin, ghrelin and the IGF-I system seem to play an important role in the regulation of body composition throughout life, but the mechanisms are not well understood. The aim of our study was to analyse the distribution among sexes and all decades of the adult life of adiponectin, resistin and ghrelin and their relationship with anthropometric, body composition parameters and the IGF-I system.
  
  
  METHODS
  One hundred and thirty-four men and 127 healthy women were included in the study.
  
  
  METHODS
  Plasma concentration of adiponectin, resistin, ghrelin, total IGF-I, free IGF-I and IGFBP-3 were determined in all subjects. Body composition was evaluated by bioelectrical impedance.
  
  
  RESULTS
  Resistin and ghrelin were not affected by age. Plasma adiponectin correlated negatively with age, body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), fat mass (FM) and body fat (BF) in men. Adiponectin correlated negatively with WHR and positively with free IGF-I in women. Resistin correlated positively with BMI and WC only in men, and ghrelin correlated positively with WC, BMI and FM and negatively with free IGF-I in men. In multiple regression analysis adiponectin remained associated with WHR (beta=-0.19, P=0.01) in women. Resistin was positively associated with BMI (beta=0.30, P=0.003) in women and ghrelin was negatively related to free IGF-I (beta=-0.158, P=0.019) in men.
  
  
  CONCLUSIONS
  Plasma adiponectin declines with age and is negatively associated with FM in men. Our data suggest the existence of a positive correlation of adiponectin and the IGF-I axis in women and of an inverse relationship between ghrelin and the IGF-I system in men.
authors.affiliation: Endocrinology and Diabetes Unit, Hospital Universitari de Bellvitge, Barcelona, Spain. nuriavilarrasa@yahoo.es
authors.forename: Nuria
authors.initials: N
authors.lastname: Vilarrasa
authors.forename: Joan
authors.initials: J
authors.lastname: Vendrell
authors.forename: Javier
authors.initials: J
authors.lastname: Maravall
authors.forename: Montse
authors.initials: M
authors.lastname: Broch
authors.forename: Araceli
authors.initials: A
authors.lastname: Estepa
authors.forename: Anna
authors.initials: A
authors.lastname: Megia
authors.forename: Joan
authors.initials: J
authors.lastname: Soler
authors.forename: Inma
authors.initials: I
authors.lastname: Simón
authors.forename: C
authors.initials: C
authors.lastname: Richart
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Gómez
mesh_terms: D052242:Adiponectin; D000328:Adult; D000375:Aging / Q000097:blood*; D000886:Anthropometry; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D005260:Female; D054439:Ghrelin; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D012016:Reference Values; D052243:Resistin; D012737:Sex Factors
chemical_list: D052242:Adiponectin; D054439:Ghrelin; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; D036361:Peptide Hormones; C499624:RETN protein, human; D052243:Resistin; D007334:Insulin-Like Growth Factor I