title: The association between birth size and atopy in young North-European adults.
abstract: BACKGROUND
  There is evidence that atopic disorders may begin in intra-uterine life; however, studies of birth characteristics and atopy show conflicting results.
  
  
  METHODS
  We wanted to investigate the association of birth weight and head circumference with serum total or specific IgE, allergic rhinitis or eczema while addressing the influence of demographic and geographical factors. In this historic prospective cohort study, data were collected from birth records for 1683 men and women born in 1947-1973, from six Nordic-Baltic populations participating in the European Community Respiratory Health Survey. Blood tests for the measurement of serum total and specific IgE were available for 1494 subjects. In multiple regression analyses, adjustments were made for birth length, gender, age, study centre, adult body mass index, level of education, parental and adult smoking. RESULTS There was no association of birth weight (n=1230) and head circumference (n=285) with serum total IgE, specific IgE antibodies, allergic rhinitis or eczema. There were neither significant interactions by gender or age, nor heterogeneity between the study centres in the analyses of birth weight and adult atopy.
  
  
  CONCLUSIONS
  Birth size was not associated with atopy among adults in this large Nordic-Baltic population study.
authors.affiliation: Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway. birger.lerum@helse-bergen.no
authors.forename: B N
authors.initials: BN
authors.lastname: Laerum
authors.forename: C
authors.initials: C
authors.lastname: Svanes
authors.forename: T
authors.initials: T
authors.lastname: Wentzel-Larsen
authors.forename: A
authors.initials: A
authors.lastname: Gulsvik
authors.forename: M
authors.initials: M
authors.lastname: Iversen
authors.forename: T
authors.initials: T
authors.lastname: Gislason
authors.forename: R
authors.initials: R
authors.lastname: Jögi
authors.forename: E
authors.initials: E
authors.lastname: Norrman
authors.forename: C
authors.initials: C
authors.lastname: Janson
authors.forename: E
authors.initials: E
authors.lastname: Omenaas
mesh_terms: D000328:Adult; D017677:Age Distribution; D001724:Birth Weight / Q000276:immunology*; D003718:Denmark / Q000453:epidemiology; D004485:Eczema / Q000453:epidemiology / Q000276:immunology; D004957:Estonia / Q000453:epidemiology; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D011446:Prospective Studies; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000276:immunology*; D017678:Sex Distribution; D013548:Sweden / Q000453:epidemiology
chemical_list: D007073:Immunoglobulin E