title: Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure.
abstract: We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.
authors.affiliation: I. P. Pavlov St. Petersburg State Medical University, Russia. na.gavrish@mail.ru
authors.forename: N A
authors.initials: NA
authors.lastname: Gavrisheva
authors.forename: V V
authors.initials: VV
authors.lastname: Malinin
authors.forename: T P
authors.initials: TP
authors.lastname: Ses
authors.forename: K L
authors.initials: KL
authors.lastname: Kozlov
authors.forename: A V
authors.initials: AV
authors.lastname: Panchenko
authors.forename: A Yu
authors.initials: AY
authors.lastname: Titkov
mesh_terms: D000818:Animals; D002196:Capillaries / Q000166:cytology; D002199:Capillary Permeability / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D017537:Mesenteric Artery, Inferior / Q000166:cytology / Q000187:drug effects; D051381:Rats; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D004151:Dipeptides; D016212:Transforming Growth Factor beta; C415909:lysylglutamic acid