title: Synthesis of the tetrahydroisoquinoline alkaloid (+/-)-renieramycin G and A (+/-)-lemonomycinone analogue from a common intermediate.
abstract: The total synthesis of tetrahydroisoquinoline alkaloids (+/-)-renieramycin G (4) and a lemonomycinone analogue (7) is described. A general strategy to synthesize both the mono- and bistetrahydroisoquinoline alkaloids from a common advanced intermediate, 17, is presented.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712.
authors.forename: Philip
authors.initials: P
authors.lastname: Magnus
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Matthews
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D044005:Tetrahydroisoquinolines; C507293:lemonomycinone; C507294:renieramycin G