title: [Case of membranous nephropathy associated with argyria].
abstract: We experienced a case of membranous nephropathy associated with argyria. The patient was a 78-year-old woman who had noticed blue skin of the face and azure lunulae for 8 years. She was admitted to our hospital for edema and proteinuria. She was diagnosed as membranous nephropathy by needle renal biopsy, and treated with prednisolone. Her proteinuria disappeared after 63 days. We investigated the blue skin of her face and azure lunulae. Skin biopsy was performed and black granules deposited in the upper layer of the corium were observed. The granules were identified with silver by EDS (energy-dispersive X-ray spectroscopy) analysis. Membranous nephropathy associated with gold or mercury has been reported, but association with silver has not been reported. We considered that this is a rare case of membranous nephropathy associated with silver.
authors.affiliation: Kameda Medical Center, Department of Nephrology, Chiba, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Aya
authors.initials: A
authors.lastname: Eguchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Kamio
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Mamiko
authors.initials: M
authors.lastname: Ohara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D001129:Argyria / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000209:etiology*; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D007668:Kidney / Q000473:pathology; D012834:Silver / Q000009:adverse effects / Q000302:isolation & purification; D012867:Skin / Q000473:pathology; D013052:Spectrometry, X-Ray Emission
chemical_list: D012834:Silver