title: Injectable biodegradable hydrogels composed of hyaluronic acid-tyramine conjugates for drug delivery and tissue engineering.
abstract: The sequential injection of hyaluronic acid-tyramine conjugates and enzymes forms biodegradable hydrogels in vivo by enzyme-induced oxidative coupling, offering high potential as a promising biomaterial for drug delivery and tissue engineering.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01 Singapore 138669. mkurisawa@ibn.a-star.edu.sg
authors.forename: Motoichi
authors.initials: M
authors.lastname: Kurisawa
authors.forename: Joo Eun
authors.initials: JE
authors.lastname: Chung
authors.forename: Yi Yan
authors.initials: YY
authors.lastname: Yang
authors.forename: Shu Jun
authors.initials: SJ
authors.lastname: Gao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uyama
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D006735:Horseradish Peroxidase / Q000008:administration & dosage / Q000493:pharmacokinetics; D006820:Hyaluronic Acid / Q000737:chemistry*; D006821:Hyaluronoglucosaminidase / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D023822:Tissue Engineering; D014439:Tyramine / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D006820:Hyaluronic Acid; D006735:Horseradish Peroxidase; D006821:Hyaluronoglucosaminidase; D014439:Tyramine