title: [Effects of microencapsulated CHO cells modified with maspin gene on the motility and adhesiveness of breast carcinoma cells Bcap37].
abstract: OBJECTIVE
  To investigate the effects of microencapsulated Chinese hamster ovary (CHO) cells modified with maspin gene on the motility and adhesiveness of breast carcinoma cells Bcap37 and to explore the possibility and feasibility of its clinical application in treatment of malignant tumors.
  
  
  METHODS
  After the Bcap37 cells were co-cultured with the microencapsulated CHO cells modified with maspin gene, their motility and adhesion to vascular endothelial cells (ECV304), changes in CD44v6 and E-cadherin expression were examined.
  
  
  RESULTS
  After the treatment, the motility of Bcap37 cells, their adhesion to vascular endothelial cells ECV304 and the CD44v6 expression were significantly reduced. The adhesiveness of Bcap37 cells and their E-cadherin expression were significantly enhanced.
  
  
  CONCLUSIONS
  The microencapsulated CHO cells modified with maspin gene decrease motility and adhesiveness of breast carcinoma cells Bcap37, which help explain the anti-metastatic effects of maspin.
authors.affiliation: Department of Oncology, Hangzhou First People's Hospital, Hangzhou 310006, China. ylong215@sina.com
authors.forename: Yue-long
authors.initials: YL
authors.lastname: Pan
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
authors.forename: Jia-ping
authors.initials: JP
authors.lastname: Peng
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D016466:CHO Cells; D002214:Capsules; D002448:Cell Adhesion; D002465:Cell Movement; D018920:Coculture Techniques; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis / Q000235:genetics; D000091402:Prohibitins; D015843:Serpins / Q000235:genetics*; D014407:Tumor Cells, Cultured
chemical_list: C112697:CD44v6 antigen; D002214:Capsules; D006023:Glycoproteins; D018960:Hyaluronan Receptors; C000717331:PHB2 protein, human; D000091402:Prohibitins; C085344:SERPIN-B5; D015843:Serpins