Shortcut to fmoc-protected phosphinic pseudodipeptidic blocks.
A three-component condensation reaction of Fmoc-carbamate, aldehydes, and alkylphosphinic acids provides a new, direct, and efficient method for synthesizing Fmoc-protected phosphinic pseudodipeptidic blocks, directly usable for solid-phase peptide synthesis. [reaction: see text]
Matziari
Magdalini
M
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Yiotakis
Athanasios
A
D020650:Combinatorial Chemistry Techniques; D005449:Fluorenes / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D010721:Phosphinic Acids / Q000737:chemistry*
D005449:Fluorenes; D010455:Peptides; D010721:Phosphinic Acids