Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women.
SULT1A1 is involved in biotransformation of many endogenous and exogenous substrates, such as drugs, hormones and tobacco smoke carcinogens. A polymorphism in the sulfotransferase 1A1 gene (SULT1A1) results in an amino acid change from Arg to His at codon 213. The His allele (SULT1A1*2) has been shown to encode a protein with much lower catalytic activity than the protein encoded by the Arg allele (SULT1A1*1). We examined whether this polymorphism modified breast cancer risk in a Finnish-Caucasian study population consisting of 483 breast cancer patients and 482 healthy population controls. No significant genotype effects were seen in the overall breast cancer risk. However, a decreased risk of breast cancer was found among premenopausal women with at least three pregnancies and at least one SULT1A1*2 allele (odds ratio = 0.23, 95% confidence interval = 0.09-0.63) compared to women with two SULT1A1*1 alleles. Our results suggest that the SULT1A1 genotype is not an important risk factor for breast cancer in general, but may modify the risk among premenopausaul women with high parity.
Sillanpää
Pia
P
Finnish Institute of Occupational Health, Helsinki, Finland.
Kataja
Vesa
V
Eskelinen
Matti
M
Kosma
Veli-Matti
VM
Uusitupa
Matti
M
Vainio
Harri
H
Mitrunen
Katja
K
Hirvonen
Ari
A
D000293:Adolescent; D000328:Adult; D015239:Arylsulfotransferase / Q000235:genetics*; D001943:Breast Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017697:Premenopause / Q000235:genetics*; D012307:Risk Factors
D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human