Preliminary observations of paranoia in a human laboratory study of cocaine.
Cocaine-induced paranoia (CIP) has recently shown a relationship to genetic factors that may moderate disulfiram treatment response in cocaine-dependent individuals. However, little research has examined CIP under controlled laboratory conditions. This study examined subjective and physiological responses to a 0.4 mg/kg dose of smoked cocaine in a human laboratory setting with 23 male and 21 female cocaine users. Twenty-nine of 44 participants (67%) reported feeling Paranoid/Suspicious in response to cocaine. Those who reported feeling Paranoid/Suspicious were more likely to be older and male. Further studies are warranted to investigate the mechanisms of gender influence on CIP, and CIP in pharmacotherapy development for cocaine-dependent individuals.
Mooney
Marc
M
University of California, San Francisco, 401 Parnassus Avenue, Box 0984, San Francisco, CA 94143-0984, USA. mmooney@lppi.ucsf.edu
Sofuoglu
Mehmet
M
Dudish-Poulsen
Susan
S
Hatsukami
Dorothy K
DK
D000328:Adult; D001921:Brain / Q000187:drug effects; D019970:Cocaine-Related Disorders / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010259:Paranoid Disorders / Q000139:chemically induced*; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D012737:Sex Factors