Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.
We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia. The patient was readmitted with symptoms of rhinorrhea, poor feeding, and decreased activity level. She was found to have diffuse pulmonary infiltrates on chest radiograph and a marked peripheral eosinophilia without leukocytosis. After discontinuing captopril and starting systemic steroids, her symptomatology rapidly improved, and her eosinophilia and radiographic abnormalities both resolved.
Slesnick
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TC
The Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Baylor College of Medicine, 6621 Fannin Avenue, MC 19345-C, Houston, TX 77030, USA.
Mott
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AR
Fraser
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Chang
A C
AC
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects; D002216:Captopril / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D005260:Female; D018610:Heart Bypass, Right; D006330:Heart Defects, Congenital / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D007223:Infant; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002216:Captopril