title: [Gamma knife treatment for pituitary adenomas].
abstract: OBJECTIVE
  To evaluate the function and effect of Gamma knife radiosurgery (GKR) in controlling the tumor growth and improving endocrinological abnormality of pituitary adenomas.
  
  
  METHODS
  Two hundred and twenty-eight cases of pituitary adenoma were treated with Leksell Gamma knife. 1.0 Tesla MRI and Gamma-Plan system were used to orientate the tumor. The margin dose was 12 - 35 Gy, mean 21.3 Gy; the center does was 24 - 70 Gy, mean 46.6 Gy (NFA, 31.8 Gy; FA, 50.3 Gy).
  
  
  RESULTS
  One hundred and sixteen cases (NFA, 28; FA, 88) were followed up for 4 - 67 months, and the mean was 27.4 months. The growth of tumors in 113 cases (97.4%) was controlled. The tumor volume became smaller in 98 cases (84.5%). Three cases (2.6%) grew larger in tumor size. A significant decrease of excessive hormone production was seen in 89.8% of the patients, and the endocrinological normalization rate was 49.7% (PRL, 47.2%; GH, 57.1%; ACTH, 55.6%). Postradiosurgical complications were seen in 6%.
  
  
  CONCLUSIONS
  Gamma knife radiosurgery is safe and effective in controlling the tumor growth and improving endocrinological abnormality of pituitary adenoma.
authors.affiliation: Gamma knife Treatment and Research Center, Xiangya Hosptial, Central South University, Changsha 410008, China. Gamma2000@tom.com
authors.forename: Bin
authors.initials: B
authors.lastname: Qiu
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Ma
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Liu
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Hou
authors.forename: Jian-Bing
authors.initials: JB
authors.lastname: Tang
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000295:instrumentation; D016896:Treatment Outcome