A model of the effects of applied electric fields on neuronal synchronization.
We examine the effects of applied electric fields on neuronal synchronization. Two-compartment model neurons were synaptically coupled and embedded within a resistive array, thus allowing the neurons to interact both chemically and electrically. In addition, an external electric field was imposed on the array. The effects of this field were found to be nontrivial, giving rise to domains of synchrony and asynchrony as a function of the heterogeneity among the neurons. A simple phase oscillator reduction was successful in qualitatively reproducing these domains. The findings form several readily testable experimental predictions, and the model can be extended to a larger scale in which the effects of electric fields on seizure activity may be simulated.
Park
Eun-Hyoung
EH
The Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030, USA.
Barreto
Ernest
E
Gluckman
Bruce J
BJ
Schiff
Steven J
SJ
So
Paul
P
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D003198:Computer Simulation; D003344:Cortical Synchronization; D004307:Dose-Response Relationship, Radiation; D004553:Electric Conductivity; D004558:Electric Stimulation / Q000379:methods*; D008959:Models, Neurological; D016571:Neural Networks, Computer; D009474:Neurons / Q000502:physiology / Q000528:radiation effects*