title: Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum.
abstract: The leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kaneh.) was investigated by gas chromatography-mass spectrometry, and 21 compounds were identified. The major constituents of leaf essential oil were the monoterpenes 1,8-cineole (17.0%) and santolina triene (14.2%) and the sesquiterpenes spathulenol (15.7%) and caryophyllene oxide (11.2%). In the antiinflammatory activity assay, we demonstrated that the essential oil has a higher capacity to inhibit proIL-1beta protein expression induced by LPS-treated J774A.1 murine macrophage. At dosages of 60 microg/mL, essential oil clearly inhibited proIL-1beta protein expression. Furthermore, a dose of 60 microg/mL of essential oil was effectively inhibitory for IL-1beta and IL-6 production but not for TNF-alpha, suggesting that essential oil was bioactive in antiinflammation in vitro. This study is the first to report antiinflammatory activity of extracts obtained from the leaf essential oil of C. osmophloeum.
authors.affiliation: Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan 717, Taiwan.
authors.forename: Louis Kuoping
authors.initials: LK
authors.lastname: Chao
authors.forename: Kuo-Feng
authors.initials: KF
authors.lastname: Hua
authors.forename: Hsien-Yeh
authors.initials: HY
authors.lastname: Hsu
authors.forename: Sen-Sung
authors.initials: SS
authors.lastname: Cheng
authors.forename: Ju-Yun
authors.initials: JY
authors.lastname: Liu
authors.forename: Shang-Tzen
authors.initials: ST
authors.lastname: Chang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D027424:Cinnamomum / Q000737:chemistry*; D016207:Cytokines / Q000096:biosynthesis; D008401:Gas Chromatography-Mass Spectrometry; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D013729:Terpenes / Q000032:analysis
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D008070:Lipopolysaccharides; D009822:Oils, Volatile; D013729:Terpenes