title: [Vascularization of the head and neck during development].
abstract: One of the earliest priorities of the embryonic vascular system is to ensure the metabolic needs of the head. This review covers some of the principles that govern the cellular assembly and localization of blood vessels in the head. In order to understand the development and organization of the cephalic vascular tree, one needs to recall the morphogenetic movements underlying vertebrate head formation and giving rise to the constituent cells of the vascular system. Some of the major signaling molecules involved in vascular development are discussed, including the angiopoietins, the endothelins, the FGFs, the Notch receptors, the PDGFs, Sonic hedgehog, the TGF family and the VEGFs, in order to underline similarities between embryonic and postnatal vascular development, even in the context of increasingly divergent form.
authors.affiliation: INSERM U-393, Hôpital Necker - Enfants Malades, 149 rue de Sèvres, 75743 Paris 15.
authors.forename: E
authors.initials: E
authors.lastname: Detrait
authors.forename: H C
authors.initials: HC
authors.lastname: Etchevers
mesh_terms: D006257:Head / Q000098:blood supply* / Q000196:embryology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D009333:Neck / Q000098:blood supply* / Q000196:embryology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins