Sugar amino acids in designing new molecules.
Emulating the basic principles followed by nature to build its vast repertoire of biomolecules, organic chemists are developing many novel multifunctional building blocks and using them to create 'nature-like' and yet unnatural organic molecules. Sugar amino acids constitute an important class of such polyfunctional scaffolds where the carboxyl, amino and hydroxyl termini provide an excellent opportunity to organic chemists to create structural diversities akin to Nature's molecular arsenal. This article describes some of our works on various sugar amino acids and many other related building blocks, like furan amino acids, pyrrole amino acids etc. used in wide-ranging peptidomimetic studies.
Chakraborty
Tushar Kanti
TK
Indian Institute of Chemical Tecnology, Hyderabad, 500 007, India. chakraborty@iict.res.in
Srinivasu
Pothukanuri
P
Tapadar
Subhasish
S
Mohan
Bajjuri Krishna
BK
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002240:Carbohydrate Sequence; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004743:Enkephalin, Leucine / Q000138:chemical synthesis / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry; D034444:Peptoids / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry; D013400:Sugar Acids / Q000138:chemical synthesis / Q000737:chemistry*
D000596:Amino Acids; D005663:Furans; D010456:Peptides, Cyclic; D034444:Peptoids; D011758:Pyrroles; D013400:Sugar Acids; D004743:Enkephalin, Leucine