title: Sodium monofluoroacetate (Compound 1080) poisoning in dogs.
abstract: Sodium monofluoroacetate (Compound 1080) is a widely used pesticide for control of feral animals such as the fox. Accidental poisoning of domestic animals occurs despite strict regulations on 1080 usage. Dogs are particularly susceptible to the toxin. The mechanism of 1080 toxicity, susceptibility of target and non-target species, persistence of 1080 in the environment and risk of accidental poisoning are discussed. Particular emphasis is placed on 1080 toxicity in the dog. Early recognition of intoxication is most important for prognosis and relies upon characteristic clinical signs and diagnostic findings. The treatment of 1080 intoxication remains a challenge with no proven antidotes. However, there are possible benefits from monoacetin, acetamide, calcium salts, colestipol, activated charcoal, peritoneal dialysis, sodium bicarbonate, neurotransmitter modulators and four-methylpyrazole. A recommended treatment protocol for 1080 toxicosis in dogs is included. Safety measures such as the use of wire dog muzzles and investigating alternatives to 1080 in pest control programs may be the key to reducing the incidence of future accidental poisonings.
authors.affiliation: University Veterinary Centre, Faculty of Veterinary Science, The University of Sydney, Werombi Road, Camden, New South Wales 2570.
authors.forename: C S S
authors.initials: CS
authors.lastname: Goh
authors.forename: D R
authors.initials: DR
authors.lastname: Hodgson
authors.forename: S M
authors.initials: SM
authors.lastname: Fearnside
authors.forename: J
authors.initials: J
authors.lastname: Heller
authors.forename: N
authors.initials: N
authors.lastname: Malikides
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D001315:Australia; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D004285:Dogs; D005463:Fluoroacetates / Q000506:poisoning*; D011379:Prognosis; D012307:Risk Factors; D012378:Rodenticides / Q000506:poisoning*
chemical_list: D005463:Fluoroacetates; D012378:Rodenticides; C014815:fluoroacetic acid