Lipoxygenase inhibitory constituents from Indigofera oblongifolia.
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with beta-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.
Sharif
Ahsan
A
International Centre for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan.
Ahmed
Ejaz
E
Malik
Abdul
A
Riaz
Naheed
N
Afza
Nighat
N
Nawaz
Sarfraz Ahmad
SA
Arshad
Muhammad
M
Shah
Muhammad Raza
MR
Choudhary
Muhammad Iqbal
MI
D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D002934:Cinnamates / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000302:isolation & purification* / Q000494:pharmacology; D062385:Hydroxybenzoates / Q000302:isolation & purification; D029883:Indigofera / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D012855:Sitosterols / Q000302:isolation & purification; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D002934:Cinnamates; D005227:Fatty Acids; D062385:Hydroxybenzoates; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D012855:Sitosterols; D014966:Xanthenes; C510794:indigin; C510795:indigoferic acid; C032948:3-hydroxybenzoic acid; C025473:gamma-sitosterol