[Ester derivatives of nucleoside inhibitors of reverse transcriptase: I. Molecular transport systems for 3'-azido-3'-deoxythymidine and 2',3'-didehydro-3'-deoxythymidine].
The methods of synthesis of the derivatives of nucleoside analogues esterified with various aliphatic, aromatic, and heteroaromatic acids and the construction from them of molecular transport systems that involve lipids, carbohydrates, peptides, and amino acids are discussed. The characteristics of the biological activity of a number of such systems are described.
Berezovskaia
Iu V
IuV
Chudinov
M V
MV
D001692:Biological Transport; D004952:Esters; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D018119:Stavudine / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D015215:Zidovudine / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology
D004952:Esters; D009705:Nucleosides; D011355:Prodrugs; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D018119:Stavudine