title: Mammary carcinoma with osteoclast-like giant cells: a study of four cases and a review of literature.
abstract: Mammary carcinoma with osteoclast-like giant cells (OGCs) is an extremely rare tumor. To the best of our knowledge, only 45 cases have been reported in the literature. Here we report four additional cases of this tumor. The fine-needle aspiration cytology was performed in all four cases, showing an abundance of giant cells and mononucleated stromal cells in intimate association with low- or medium-grade malignant epithelial clusters. Histologically, cribriform patterns predominated in three cases. In one case, OGCs were more pronounced in the vicinity of ductal carcinoma in situ accompanied by marked stromal angiogenesis. This study, as well as review of the literature, underlines the characteristic features of this rare histologic type of carcinoma.
authors.affiliation: Department of Pathology, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York 10021, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Cai
authors.forename: June
authors.initials: J
authors.lastname: Koizumi
authors.forename: Madeline
authors.initials: M
authors.lastname: Vazquez
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology