title: Sulfotransferase 1A1 genotype as a potential modifier of breast cancer risk among premenopausal women.
abstract: SULT1A1 is involved in biotransformation of many endogenous and exogenous substrates, such as drugs, hormones and tobacco smoke carcinogens. A polymorphism in the sulfotransferase 1A1 gene (SULT1A1) results in an amino acid change from Arg to His at codon 213. The His allele (SULT1A1*2) has been shown to encode a protein with much lower catalytic activity than the protein encoded by the Arg allele (SULT1A1*1). We examined whether this polymorphism modified breast cancer risk in a Finnish-Caucasian study population consisting of 483 breast cancer patients and 482 healthy population controls. No significant genotype effects were seen in the overall breast cancer risk. However, a decreased risk of breast cancer was found among premenopausal women with at least three pregnancies and at least one SULT1A1*2 allele (odds ratio = 0.23, 95% confidence interval = 0.09-0.63) compared to women with two SULT1A1*1 alleles. Our results suggest that the SULT1A1 genotype is not an important risk factor for breast cancer in general, but may modify the risk among premenopausaul women with high parity.
authors.affiliation: Finnish Institute of Occupational Health, Helsinki, Finland.
authors.forename: Pia
authors.initials: P
authors.lastname: Sillanpää
authors.forename: Vesa
authors.initials: V
authors.lastname: Kataja
authors.forename: Matti
authors.initials: M
authors.lastname: Eskelinen
authors.forename: Veli-Matti
authors.initials: VM
authors.lastname: Kosma
authors.forename: Matti
authors.initials: M
authors.lastname: Uusitupa
authors.forename: Harri
authors.initials: H
authors.lastname: Vainio
authors.forename: Katja
authors.initials: K
authors.lastname: Mitrunen
authors.forename: Ari
authors.initials: A
authors.lastname: Hirvonen
mesh_terms: D000293:Adolescent; D000328:Adult; D015239:Arylsulfotransferase / Q000235:genetics*; D001943:Breast Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017697:Premenopause / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human