Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation.
Asthma, like many inflammatory disorders, is affected by psychological stress, suggesting that reciprocal modulation may occur between peripheral factors regulating inflammation and central neural circuitry underlying emotion and stress reactivity. Despite suggestions that emotional factors may modulate processes of inflammation in asthma and, conversely, that peripheral inflammatory signals influence the brain, the neural circuitry involved remains elusive. Here we show, using functional magnetic resonance imaging, that activity in the anterior cingulate cortex and insula to asthma-relevant emotional, compared with valence-neutral stimuli, is associated with markers of inflammation and airway obstruction in asthmatic subjects exposed to antigen. This activation accounts for > or =40% of the variance in the peripheral markers and suggests a neural basis for emotion-induced modulation of airway disease in asthma. The anterior cingulate cortex and insula have been implicated in the affective evaluation of sensory stimulation, regulation of homeostatic responses, and visceral perception. In individuals with asthma and other stress-related conditions, these brain regions may be hyperresponsive to disease-specific emotional and afferent physiological signals, which may contribute to the dysregulation of peripheral processes, such as inflammation.
Rosenkranz
Melissa A
MA
Department of Psychology, Laboratory for Affective Neuroscience, University of Wisconsin, 1202 West Johnson Street, Madison, WI 53706, USA.
Busse
William W
WW
Johnstone
Tom
T
Swenson
Cheri A
CA
Crisafi
Gina M
GM
Jackson
Maryjo M
MM
Bosch
Jos A
JA
Sheridan
John F
JF
Davidson
Richard J
RJ
D000402:Airway Obstruction; D000485:Allergens / Q000494:pharmacology; D001249:Asthma / Q000209:etiology / Q000473:pathology / Q000523:psychology*; D015415:Biomarkers / Q000032:analysis; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways; D013183:Sputum / Q000737:chemistry
D000485:Allergens; D015415:Biomarkers