Imipenem-cilastatin induced pure white cell aplasia.
Antibiotic-induced severe neutropenia and less frequently agranulocytosis has been reported. In most of these cases a relatively normal myelopoiesis is found. We report on the first case of agranulocytosis with histological evidence of pure white cell aplasia associated with imipenem-cilastatin treatment.
Kalambokis
Georgios
G
Vassou
Amalia
A
Bourantas
Konstantinos
K
Tsianos
Epameinondas V
EV
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced*; D015377:Cilastatin / Q000009:adverse effects; D000077728:Cilastatin, Imipenem Drug Combination; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015378:Imipenem / Q000009:adverse effects; D007958:Leukocyte Count
D004338:Drug Combinations; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination