title: Predictors of hypotension after induction of general anesthesia.
abstract: Hypotension after induction of general anesthesia is a common event. In the current investigation, we sought to identify the predictors of clinically significant hypotension after the induction of general anesthesia. Computerized anesthesia records of 4096 patients undergoing general anesthesia were queried for arterial blood pressure (BP), demographic information, preoperative drug history, and anesthetic induction regimen. The median BP was determined preinduction and for 0-5 and 5-10 min postinduction of anesthesia. Hypotension was defined as either: mean arterial blood pressure (MAP) decrease of >40% and MAP <70 mm Hg or MAP <60 mm Hg. Overall, 9% of patients experienced severe hypotension 0-10 min postinduction of general anesthesia. Hypotension was more prevalent in the second half of the 0-10 min interval after anesthetic induction (P < 0.001). In 2406 patients with retrievable outcome data, prolonged postoperative stay and/or death was more common in patients with versus those without postinduction hypotension (13.3% and 8.6%, respectively, multivariate P < 0.02). Statistically significant multivariate predictors of hypotension 0-10 min after anesthetic induction included: ASA III-V, baseline MAP <70 mm Hg, age > or =50 yr, the use of propofol for induction of anesthesia, and increasing induction dosage of fentanyl. Smaller doses of propofol, etomidate, and thiopental were not associated with less hypotension. To avoid severe hypotension, alternatives to propofol anesthetic induction (e.g., etomidate) should be considered in patients older than 50 yr of age with ASA physical status > or =3. We conclude that it is advisable to avoid propofol induction in patients who present with baseline MAP <70 mm Hg.
authors.affiliation: Departments of Anesthesiology and Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York.
authors.forename: David L
authors.initials: DL
authors.lastname: Reich
authors.forename: Sabera
authors.initials: S
authors.lastname: Hossain
authors.forename: Marina
authors.initials: M
authors.lastname: Krol
authors.forename: Bernard
authors.initials: B
authors.lastname: Baez
authors.forename: Puja
authors.initials: P
authors.lastname: Patel
authors.forename: Ariel
authors.initials: A
authors.lastname: Bernstein
authors.forename: Carol A
authors.initials: CA
authors.lastname: Bodian
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D000768:Anesthesia, General / Q000009:adverse effects*; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D016208:Databases, Factual; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D015233:Models, Statistical; D011237:Predictive Value of Tests; D015742:Propofol / Q000009:adverse effects; D012189:Retrospective Studies; D018570:Risk Assessment; D013874:Thiopental
chemical_list: D018686:Anesthetics, Intravenous; D013874:Thiopental; D005283:Fentanyl; D015742:Propofol