Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression.
OBJECTIVE
To investigate clinical significance of Pin1 and beta-catenin expression in colorectal cancers and to demonstrate the relationship of their expression.


METHODS
The role of Pin1 and beta-catenin protein in colorectal tumorigenesis and their clinicopathologic significance were analyzed by immunohistochemistry, and the correlation between Pin1 and beta-catenin protein expressions was also studied in 124 patients with colorectal cancer who were surgically treated.


RESULTS
Normal colonic epithelium either failed to express or showed focal and weak expression of Pin1 and beta-catenin. Overexpression of Pin1 and beta-catenin protein was found in 23 (18.54%) and 50 (40.3%) of 124 colorectal cancers, respectively. Overexpression of both proteins was not related to the lymph node metastasis, tumor stage and survival period after excision. Survival analysis results indicated that tumor stage was a valuable predictor of survival. Interestingly, a significant correlation was found between Pin1 and beta-catenin protein expression.


CONCLUSIONS
Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.
Kim
Chang-Jae
CJ
Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 137-701, South Korea.
Cho
Yong-Gu
YG
Park
Yong-Gyu
YG
Nam
Suk-Woo
SW
Kim
Su-Young
SY
Lee
Sug-Hyung
SH
Yoo
Nam-Jin
NJ
Lee
Jung-Young
JY
Park
Won-Sang
WS
D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D015996:Survival Rate; D015534:Trans-Activators / Q000378:metabolism*; D015854:Up-Regulation; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D015534:Trans-Activators; D051176:beta Catenin; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase