Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds.
A persistent inflammation with large numbers of neutrophils is found in chronic wounds. Secretory products released from the neutrophils, which include proteinases and a heparin-binding protein, are detrimental to wound healing as they cause degradation of the extracellular matrix and growth factors, and promote further recruitment of neutrophils to the wound area. The neutrophil-derived elastase, cathepsin G, proteinase-3 and heparin-binding protein are cationic, and it is hypothesized that their effects can be inhibited by electrostatic binding with certain anionic polymers such as glycosaminoglycans or functionalized dextrans. A sustained delivery of such compounds alone or in combination from a biodegradable carrier may provide a stimulus for these wounds to pass to the next stage of repair.
Peplow
Philip V
PV
Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, P.O. Box 913, Dunedin, New Zealand. phil.peplow@stonebow.otago.ac.nz
D000818:Animals; D000838:Anions; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003911:Dextrans / Q000737:chemistry; D004730:Endothelium, Vascular / Q000166:cytology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005109:Extracellular Matrix / Q000378:metabolism; D005609:Free Radicals; D006025:Glycosaminoglycans / Q000502:physiology*; D006493:Heparin / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation; D008956:Models, Chemical; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D018384:Oxidative Stress; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry; D011485:Protein Binding; D055672:Static Electricity; D014945:Wound Healing
D000838:Anions; D000893:Anti-Inflammatory Agents; D003911:Dextrans; D004791:Enzyme Inhibitors; D005609:Free Radicals; D006025:Glycosaminoglycans; D011108:Polymers; D011134:Polysaccharides; D006493:Heparin