title: 1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors.
abstract: A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.
authors.affiliation: Eli Lilly and Company Ltd, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Beadle
authors.forename: John
authors.initials: J
authors.lastname: Boot
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Camp
authors.forename: Nancy
authors.initials: N
authors.lastname: Dezutter
authors.forename: Jeremy
authors.initials: J
authors.lastname: Findlay
authors.forename: Lorna
authors.initials: L
authors.lastname: Hayhurst
authors.forename: John J
authors.initials: JJ
authors.lastname: Masters
authors.forename: Roberta
authors.initials: R
authors.lastname: Penariol
authors.forename: Magnus W
authors.initials: MW
authors.lastname: Walter
mesh_terms: D002851:Chromatography, High Pressure Liquid; D014179:Neurotransmitter Uptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D014179:Neurotransmitter Uptake Inhibitors; D011804:Quinolines; D009638:Norepinephrine