title: Angio-oedema in dentistry: management of two cases using C1 esterase inhibitor.
abstract: Angio-oedema is a rare condition; it may be a hereditary or acquired form. It results from biochemical defects which cause excessive activation of the complement cascade and result in deep swellings in the skin and alimentary tract, called angio-oedema. These swellings are painful rather than itchy and not associated with urticaria, which helps to differentiate angio-oedema from allergic reactions. Even mild trauma can give rise to swelling, which may be life-threatening in the oral region. Management of two cases, one hereditary and the other acquired angio-oedema, are reported to demonstrate the use of C1 esterase inhibitor prophylaxis.
  
  
  CONCLUSIONS
  It is important that patients giving a history of angio-oedema are thoroughly investigated and, in discussion with the patient's medical team, appropriate prophylactic measures are taken to prevent swelling.
authors.affiliation: Guy's and St Thomas' NHS Trust.
authors.forename: Michal
authors.initials: M
authors.lastname: Socker
authors.forename: Carole
authors.initials: C
authors.lastname: Boyle
authors.forename: Mary
authors.initials: M
authors.lastname: Burke
mesh_terms: D000293:Adolescent; D000799:Angioedema / Q000188:drug therapy*; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use*; D003777:Dental Prophylaxis / Q000009:adverse effects; D003793:Dental Restoration, Permanent; D004487:Edema / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014081:Tooth Extraction / Q000009:adverse effects*; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D003174:Complement C1 Inactivator Proteins; D014148:Tranexamic Acid