Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds.
Two types of therapeutic agents, which have discrete yet complementary functions, self-assemble into nanofibers in water to formulate a new supramolecular hydrogel as a self-delivery biomaterial to reduce the toxicity of uranyl oxide at the wound sites.
Yang
Zhimou
Z
Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
Xu
Keming
K
Wang
Ling
L
Gu
Hongwei
H
Wei
Heng
H
Zhang
Mingjie
M
Xu
Bing
B
D000818:Animals; D002942:Circular Dichroism; D015195:Drug Design; D005449:Fluorenes; D020100:Hydrogels; D007930:Leucine / Q000031:analogs & derivatives; D051379:Mice; D008813:Mice, Inbred ICR; D008958:Models, Molecular; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D017974:Uranium Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014867:Water / Q000737:chemistry
D005449:Fluorenes; D020100:Hydrogels; D017974:Uranium Compounds; D014867:Water; C082231:N-(fluorenyl-9-methoxycarbonyl)leucine; D007930:Leucine; C047385:uranium oxide