Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.
The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
O'Hara
R
R
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550, USA. roh@leland.stanford.edu
Schröder
C M
CM
Kraemer
H C
HC
Kryla
N
N
Cao
C
C
Miller
E
E
Schatzberg
A F
AF
Yesavage
J A
JA
Murphy
G M
GM
D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology; D004252:DNA Mutational Analysis; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000235:genetics; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D012894:Sleep Stages / Q000235:genetics
D053327:Apolipoprotein E4; D001057:Apolipoproteins E