title: Antifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation.
abstract: OBJECTIVE
  This study describes the antifungal effect of extracts and compounds isolated from Drimys brasiliensis acting against dermatophytes.
  
  
  METHODS
  The activities were evaluated by using the microbroth dilution method.
  
  
  RESULTS
  Bioassay-guided fractionation of the most active extract from the bark (CHCl3) led to the isolation of the sesquiterpene drimanes polygodial, 1-beta-(p-methoxycinnamoyl)-polygodial, drimanial and 1-beta-(p-cumaroyloxy)-polygodial, which were selectively active against Epidermophyton floccosum and Tricophyton rubrum.
  
  
  CONCLUSIONS
  The selective antifungal activity reported in this paper for drimanes isolated from D. brasiliensis opens the possibility that they could be helpful for the developing of new antifungal agents for treating the difficult to eradicate dermatomycoses produced by E. floccosum.
authors.affiliation: Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, SC, Brazil. angela@univali.br
authors.forename: Angela
authors.initials: A
authors.lastname: Malheiros
authors.forename: Valdir
authors.initials: V
authors.lastname: Cechinel Filho
authors.forename: Clarisse B
authors.initials: CB
authors.lastname: Schmitt
authors.forename: Rosendo A
authors.initials: RA
authors.lastname: Yunes
authors.forename: Andrea
authors.initials: A
authors.lastname: Escalante
authors.forename: Laurq
authors.initials: L
authors.lastname: Svetaz
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay / Q000379:methods* / Q000706:statistics & numerical data; D032424:Drimys; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane