title: Aspirochlorine class compounds from Aspergillus flavus inhibit azole-resistant Candida albicans.
abstract: Dereplication of the antifungal extracts of Aspergillus flavus indicated that the primary antifungal compound present was the known aspirochlorine (1). Preparative isolation work resulted in the identification of the new compounds tetrathioaspirochlorine (2) and cyclo(D-N-methyl-Leu-L-Trp) (3).
authors.affiliation: Natural Products Support Group, SAIC-Frederick, Inc., Bldg 431, FCRDC, Frederick, Maryland 21702-1201, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Klausmeyer
authors.forename: Thomas G
authors.initials: TG
authors.lastname: McCloud
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Tucker
authors.forename: John H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: Robert H
authors.initials: RH
authors.lastname: Shoemaker
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000737:chemistry*; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D025141:Drug Resistance, Fungal; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D009183:Mycotoxins; D013141:Spiro Compounds; C119402:aspirochlorine; C504683:tetrathioaspirochlorine