title: Highly diastereoselective formation of 1,2,3-trisubstituted cyclopropane derivatives.
abstract: A highly diastereoselective formation of cyclopropane derivatives was reported. When the chiral phenylvinyl epoxide reacted with lithiated 2-alkyl-1,3-dithiane or lithiated alkyl carbonanion in the presence of HMPA, cyclopropanes bearing stereochemistry at all three positions on the ring were readily obtained in high yields of 80-97% and high dr values of 68:32-99:1. This reaction was supposed to be a tandem conjugation addition-epoxide opening sequence. [reaction: see text]
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, 730000 Lanzhou, P. R. China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Xie
authors.forename: Guoren
authors.initials: G
authors.lastname: Yue
authors.forename: Shouchu
authors.initials: S
authors.lastname: Tang
authors.forename: Xing
authors.initials: X
authors.lastname: Huo
authors.forename: Qiren
authors.initials: Q
authors.lastname: Liang
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan