[Glutathione S-transferase M1, T1 genotypes and the risk of mountain sickness].
OBJECTIVE
To explore the relationship between genetic polymorphisms of glutathione S-transferase (GST) M1, T1 and susceptibility to mountain sickness.


METHODS
Forty-three soldiers with acute mountain sickness and 80 healthy soldiers matching with sex/age and training under the same condition were divided into case group and control group. A multiple polymerase chain reaction method was used to detect GSTM1 and GSTT1 genes in genomic DNA isolated from peripheral blood cells from both cases and controls.


RESULTS
The frequency of the GSTT1 positive genotype was significantly higher in cases (69.8%) than in controls (42.5%) (P = 0.004, OR = 3.12, 95% CI 1.42 approximately 6.86). The frequency of GSTM1 negative genotype was also higher in cases (72.1%) than in controls (52.5%) (P = 0.03, OR = 2.34, 95% CI 1.05 approximately 5.02). Persons with both GSTM1 and GSTT1 negative genotypes had 5-fold more risk than those with GSTT1 negative and GSTM1 positive genotypes in developing mountain sickness (OR = 5.04, 95% CI: 1.00 approximately 25.3).


CONCLUSIONS
Genetic polymorphisms of glutathione S-transferase M1, T1 may be the risk factors in the development of mountain sickness.
Jiang
Chang-zheng
CZ
Institute of Occupational Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Li
Fang-ze
FZ
He
Mei-an
MA
Sun
Shu-yong
SY
Zhang
Shu-yu
SY
Liao
Rong
R
Jia
Shu-ya
SY
Zeng
Hua-song
HS
Wu
Tang-chun
TC
D000208:Acute Disease; D000328:Adult; D000532:Altitude Sickness / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1