title: Molecular clocks: four decades of evolution.
abstract: During the past four decades, the molecular-clock hypothesis has provided an invaluable tool for building evolutionary timescales, and has served as a null model for testing evolutionary and mutation rates in different species. Molecular clocks have also influenced the development of theories of molecular evolution. As DNA-sequencing technologies have progressed, the use of molecular clocks has increased, with a profound effect on our understanding of the temporal diversification of species and genomes.
authors.affiliation: Center for Evolutionary Functional Genomics, The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe 85287-5301, USA. s.kumar@asu.edu
authors.forename: Sudhir
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins