Sudden cardiac death and the role of device therapy in dilated cardiomyopathy.
Both nonischemic and ischemic dilated cardiomyopathy are associated with an increased risk of sudden cardiac death, most commonly as a result of ventricular tachyarrhythmias. The pathophysiology of sudden death is complex and results from the interplay of scarred myocardium with physiologic and environmental triggers. Clinical trials completed within the past decade have clarified the role of implantable defibrillators in prolonging survival and have expanded the indications for the use of these devices in patients with heart failure. This article examines the pathophysiology of sudden cardiac death and reviews the clinical trials that have defined the role of device therapy in current practice.
Jayaraj
Prash
P
Section of Electrophysiology, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA.
Monahan
Kevin M
KM
D002311:Cardiomyopathy, Dilated / Q000150:complications* / Q000628:therapy; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000295:instrumentation*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome