Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma.
Efficiency and mechanisms of action of photodynamic therapy of M-1 sarcoma were studied experimentally on rats using photodithazine, a novel chlorine photosensitizer. The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for proliferation and biosynthesis.
Romanko
Yu S
YS
State Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk. y_romanko@hotmail.com
Tsyb
A F
AF
Kaplan
M A
MA
Popuchiev
V V
VV
D000818:Animals; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007150:Immunohistochemistry; D008297:Male; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology
D017319:Photosensitizing Agents; C047635:N-methylglucosamine; D005944:Glucosamine