Single-session magnetic resonance coronary angiography and myocardial perfusion imaging using the new blood pool compound B-22956 (gadocoletic acid): initial experience in a porcine model of coronary artery disease.
OBJECTIVE
The objective of this study was to evaluate a new blood pool contrast agent, B-22956, for detecting myocardial perfusion abnormality and coronary artery stenosis by magnetic resonance imaging (MRI) in 1 setting.


METHODS
Coronary artery atherosclerotic stenoses were created in 6 miniswine. Myocardial first-pass perfusion imaging was performed with a bolus injection of 0.015 mmol/kg B-22956 during pharmacologic stress followed by postcontrast coronary artery imaging after another injection of B-22956/1. The total doses for the 6 pigs were 0.1 mmol/kg (n=3) and 0.15 mmol/kg (n=3). Perfusion upslope maps were analyzed and MR coronary artery images were reviewed by 2 readers.


RESULTS
For all 6 pigs, the normalized upslopes of the perfusion curves were 0.83+/-0.12, 0.74+/-0.15, and 0.52+/-0.05 (P<0.01 vs. normal) with normal or mild (<50% area stenosis), moderate (<50% and <75%), and severe stenosis (>75%), respectively. Mean signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in right coronary artery images improved 90% and 200%, respectively, with a total dose of 0.1 mmol/kg of B-22956. Excellent agreements (kappa=0.82) were achieved for evaluating the grade of stenosis between MR postcontrast coronary artery images and histopathology by 2 reviewers.


CONCLUSIONS
The MR blood pool contrast agent B-22956 demonstrated the ability for detecting myocardial perfusion abnormalities and coronary artery stenosis in 1 setting.
Zheng
Jie
J
Washington University in St. Louis, St. Louis, Missouri 63110, USA. zhengj@mir.wustl.edu
Li
Debiao
D
Maggioni
Fabio
F
Abendschein
Dana
D
Simonetti
Orlando
O
Laub
Gerhard
G
Finn
J Paul
JP
Gropler
Robert J
RJ
Cavagna
Friedrich M
FM
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000175:diagnosis*; D004195:Disease Models, Animal; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D018709:Statistics, Nonparametric; D013552:Swine
C440468:B-22956-1; D003287:Contrast Media; D009942:Organometallic Compounds