Pathogenesis of respiratory syncytial virus infection in the murine model.
There is a wide spectrum of illness caused by respiratory syncytial virus (RSV) infection that is caused in large part by host-related factors, such as age of the patient and degree of host immunocompetency. Although the vast majority of persons infected with RSV experience symptoms of mild upper respiratory tract infection, in some people these infections cause significant morbidity and are sometimes fatal. Although a great deal of investigation in both humans and animals has explained the timing and tropism of RSV infection and the general principles by which the immune system responds to this infection, at present we only partially understand the disparity in illness severity that can occur. This article briefly reviews the clinical sequelae of RSV infection and then focuses on the mechanisms of viral pathogenesis.
Peebles
R Stokes
RS
Vaccine Research Center, NIAID/NIH, 40 Convent Drive, Building 40, Room 2502, Bethesda, MD 20892-3017, USA. bgraham@nih.gov
Graham
Barney S
BS
D000402:Airway Obstruction / Q000503:physiopathology / Q000821:virology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000150:complications / Q000276:immunology* / Q000503:physiopathology*; D012136:Respiratory Syncytial Viruses / Q000276:immunology / Q000472:pathogenicity*