Heat shock proteins and scavenger receptors: role in adaptive immune responses.
Tumor-derived heat shock proteins have shown promise as anti-cancer vaccines in clinical trials. Heat shock proteins (HSPs) can generate potent anti-tumor immunity and elicit antigen-specific CD8+ T cell responses in murine studies. Antigen presenting cells (APC), such as macrophages and dendritic cells (DCs), can elicit antigen-specific CD8+ T cell responses mediated by HSPs. CD91 was the first identified endocytic scavenger receptor for HSPs on APC that can facilitate the process of cross-presentation. Other scavenger receptors may also play a similar role in this process. The present review critically evaluates the identified HSP endocytic receptors on APCs that may generate adaptive immune responses. A better understanding of this interaction between HSPs and APCs may further unravel mechanisms of immunoadjuvant function of HSPs.
Facciponte
John G
JG
Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA.
MacDonald
Ian J
IJ
Wang
Xiang-Yang
XY
Kim
Hyung
H
Manjili
Masoud H
MH
Subjeck
John R
JR
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D007110:Immunity, Active; D007111:Immunity, Cellular; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D051379:Mice
D015703:Antigens, CD; D006360:Heat-Shock Proteins; C475476:LRP1 protein, human; D026503:Low Density Lipoprotein Receptor-Related Protein-1