title: Effect of sesame oil on oxidative-stress-associated renal injury in endotoxemic rats: involvement of nitric oxide and proinflammatory cytokines.
abstract: This study aimed to investigate the effect of sesame oil on oxidative stress-associated renal injury induced by lipopolysaccharide in rats. The effects of sesame oil on renal injury, oxidative stress, hydroxyl radical, superoxide anion, nitric oxide, and proinflammatory cytokines were assessed after a lipopolysaccharide challenge. Sesame oil attenuated lipopolysaccharide-induced renal injury, decreased lipid peroxidation, increased the activities of superoxide dismutase, catalase, and glutathione peroxidase, reduced hydroxyl radical generation and nitric oxide production, and had no effect on superoxide anion generation in lipopolysaccharide-challenged rats. In addition, sesame oil significantly decreased tumor necrosis factor-alpha and interleukin 1beta production 1 and 6 h, respectively, after lipopolysaccharide administration in mice. Thus, sesame oil attenuates oxidative stress-associated renal injury via reduction of the production of nitric oxide and the generation of proinflammatory cytokines in endotoxemic rats.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan 70428, Taiwan.
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.forename: Shih-Bin
authors.initials: SB
authors.lastname: Su
authors.forename: Se-Ping
authors.initials: SP
authors.lastname: Chien
authors.forename: Po-Jung
authors.initials: PJ
authors.lastname: Chiang
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Li
authors.forename: Ya-Ju
authors.initials: YJ
authors.lastname: Lo
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000818:Animals; D000838:Anions; D015153:Blotting, Western; D002374:Catalase / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D019446:Endotoxemia / Q000473:pathology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D017665:Hydroxyl Radical; D007249:Inflammation; D007375:Interleukin-1 / Q000096:biosynthesis / Q000378:metabolism; D007668:Kidney / Q000473:pathology; D007962:Leukocytes / Q000166:cytology; D015227:Lipid Peroxidation; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D012715:Sesame Oil / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000838:Anions; D016207:Cytokines; D007375:Interleukin-1; D008070:Lipopolysaccharides; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D012715:Sesame Oil; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase