title: [Relationship between the R219K polymorphism of ATP-binding cassette transporter 1 gene and coronary heart disease].
abstract: To study the distribution of R219K polymorphism in ATP-Binding Cassette Transporter 1 (ABCA1) gene in Chinese Han population and the association of this polymorphism with coronary heart disease (CHD) . Genotypes were determined by PCR-RFLP approach in 417 unrelated healthy controls and 396 CHD patients. The frequencies of K allele and KK genotype for controls (0.465, 0.228) were significantly higher than those (0.381, 0.162) for patients (P<0.05). When the patients were divided into two subgroups by onset-age, the frequencies of K allele and KK genotype for early-onset patients (0.34, 0.111) were lower than those (0.419, 0.205) for late-onset patients and those for controls (P<0.05) , while there were no such differences between late-onset patients and controls. Patients with RR genotype had a higher plasma concentration of triglycerides (TG) when compared with that of KK genotype (P<0.05) . No significant differences of plasma high-density lipoprotein cholesterol (HDL-C) level were observed among patients with different genotypes. These data suggest that the R219K polymorphism in ABCA1 gene is correlated with CHD, and the ABCA1 gene KK genotype may has a function against atherosclerosis without detectable change of plasma HDL-C level in Chinese Han population.
authors.affiliation: Department of Medical Genetics , West China Hospital , Sichuan university, and the Key Laboratory of Biotherapy, Ministry of Education, Chengdu 610041 China. liyalhj@tom.com
authors.forename: Ya
authors.initials: Y
authors.lastname: Li
authors.forename: Si-Zhong
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Ma
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: He
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D000483:Alleles; D050197:Atherosclerosis / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D008076:Cholesterol, HDL; D014280:Triglycerides