title: Tetanic crisis and antiepileptic drugs. A case report.
abstract: OBJECTIVE
  We presented a rare case of tetanic crisis in a 23-year old mentally retarded woman with epilepsy after treatment by oxcarbazepine, the new anticonvulsant agent. We reviewed laboratory, radiographic and medical examinations and recommend a proper treatment in such cases.
  
  
  CONCLUSIONS
  The laboratory tests revealed only severe hypocalcemia. We described the potential role of oxcarbazepine in the induction of activity of cytochrome P 450 system of hepar and increases of less active metabolism of vitamin D. Supplementation of vitamin D and calcium in patients taking antiepileptic drugs is in the same case crucial.
authors.affiliation: Department of Endocrinology & Diabetology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Zdrojewicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dubiński
authors.forename: Aneta
authors.initials: A
authors.lastname: Jonek
authors.forename: Natalia
authors.initials: N
authors.lastname: Tomanek
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Krajewski
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002118:Calcium / Q000008:administration & dosage; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004830:Epilepsy, Tonic-Clonic / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced / Q000188:drug therapy; D008607:Intellectual Disability / Q000150:complications; D000078330:Oxcarbazepine; D013746:Tetany / Q000139:chemically induced* / Q000188:drug therapy; D014807:Vitamin D / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D000927:Anticonvulsants; D014815:Vitamins; D014807:Vitamin D; D002220:Carbamazepine; D002118:Calcium; D000078330:Oxcarbazepine