title: ALK positive inflammatory myofibroblastic tumour of the pineal region.
abstract: Inflammatory myofibroblastic tumours (IMTs) are an uncommon spindle cell neoplasm with a dense inflammatory infiltrate, usually encountered in children. IMTs of the central nervous system are extremely rare. This report describes the case of an IMT in a 61 year old man, in the pineal region. The tumour was completely excised, and immunohistochemistry demonstrated anaplastic lymphoma kinase 1 expression. There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour.
authors.affiliation: Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. alex@actualmedia.com
authors.forename: A J
authors.initials: AJ
authors.lastname: Clarke
authors.forename: T S
authors.initials: TS
authors.lastname: Jacques
authors.forename: M J
authors.initials: MJ
authors.lastname: Galloway
authors.forename: M
authors.initials: M
authors.lastname: Thom
authors.forename: N D
authors.initials: ND
authors.lastname: Kitchen
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D001932:Brain Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000201:enzymology* / Q000601:surgery; D010870:Pineal Gland; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases