[Biological activity of a new series of tertiary alcohols].
The in vitro antimicrobial activity of a new series of synthetic fluorine-substituted triaryl alcohols against the human pathogens Staphylococcus aureus, Escherichia coli, and Candida albicans was studied with the aim of overcoming multiple drug resistance and improving the clinical usefulness of antimicrobial drugs. The nature and positions of substituents attached to aromatic rings, as well as their electronegativities and sizes, seem to affect the preferred molecular conformations and, hence, the binding of the compounds to the corresponding cell receptors.
da Costa
M Rute G
MR
Curto
M Joao M
MJ
Furtado
Olivia R
OR
Savluchinske Feio
Sonia
S
Roseiro
Jose C
JC
D000438:Alcohols / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000737:chemistry / Q000494:pharmacology*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000438:Alcohols; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001555:Benzene Derivatives; D006845:Hydrocarbons, Fluorinated