[Effects of metformin on endocrine parameters and reproductive function in women with polycystic ovary syndrome].
The effect of metformin has been studied among 42 patients of reproductive age with polycystic ovary syndrome. Therapy for 6-months was associated with regular menstrual cycle in 54.3% women, (ovulation was observed in 28.6%). After therapy 19.1% patients became pregnant. Serum levels LH fell from 16.3+/-1.45 to 8.9+/-0.82 IU/l, T from 3.3+/-0.17 to 2.0+/-0.17 nmol/l, (p<0.01). We noted increase of GH from 2.7+/-0.98 to 9.0+/-1.91 nmol/l and SHBG from 36.4+/-2.6 to 58.2+/-4.11 nmol/l, (p<0.01). After therapy we observed decrease of insulin responses during oral glucose tolerance test, (p<0.05).
Valueva
L G
LG
Chernukha
G E
GE
Ametov
A S
AS
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D004703:Endocrine System / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000187:drug effects*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000187:drug effects* / Q000378:metabolism; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D011956:Receptors, Cell Surface; C063572:sex hormone-binding globulin receptor; D019382:Human Growth Hormone; D007986:Luteinizing Hormone; D008687:Metformin