1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors.
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion.
Beadle
Christopher D
CD
Eli Lilly and Company Ltd, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK.
Boot
John
J
Camp
Nicholas P
NP
Dezutter
Nancy
N
Findlay
Jeremy
J
Hayhurst
Lorna
L
Masters
John J
JJ
Penariol
Roberta
R
Walter
Magnus W
MW
D002851:Chromatography, High Pressure Liquid; D014179:Neurotransmitter Uptake Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology*; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D014179:Neurotransmitter Uptake Inhibitors; D011804:Quinolines; D009638:Norepinephrine