title: Health-related quality of life one month after thrombolysis or primary PCI in patients with ST-elevation infarction. A DANAMI-2 sub-study.
abstract: OBJECTIVE
  To evaluate the health-related quality of life (HRQoL) following Primary percutaneous coronary intervention (PCI) or thrombolytic treatment for ST-elevation myocardial infarction (STEMI).
  
  
  METHODS
  A questionnaire based study on patients randomised in the DANAMI-2 study to Primary PCI or thrombolysis for STEMI. A total of 1 351 patients (93.2% response rate) randomised in the DANAMI-2 study completed the HRQoL questionnaire one month after the infarction.
  
  
  RESULTS
  With respect to the primary end-points (SF-36 physical component score, angina pectoris, and dyspnoea), patients randomised to primary PCI scored better on the SF-36 physical component score (PCS) (p=0.007), and reported significantly less angina pectoris (p=0.010) and dyspnoea (p=0.010). Higher scores among PCI patients were also found on the SF-36 scales physical functioning (p=0.015), role-physical (p=0.017), and general health (p=0.009).
  
  
  CONCLUSIONS
  The results in this study support the hypothesis that primary PCI is superior to thrombolysis in treating STEMI, not only in clinical outcome, but also in quality of life outcome.
authors.affiliation: Department of Social Medicine, University of Copenhagen, Denmark. o.mortensen@dadlnet.dk
authors.forename: O S
authors.initials: OS
authors.lastname: Mortensen
authors.forename: J B
authors.initials: JB
authors.lastname: Bjorner
authors.forename: B
authors.initials: B
authors.lastname: Oldenburg
authors.forename: B
authors.initials: B
authors.lastname: Newman
authors.forename: M
authors.initials: M
authors.lastname: Groenvold
authors.forename: J K
authors.initials: JK
authors.lastname: Madsen
authors.forename: H R
authors.initials: HR
authors.lastname: Andersen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001007:Anxiety / Q000628:therapy; D003718:Denmark / Q000453:epidemiology; D003863:Depression / Q000628:therapy; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D011788:Quality of Life; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D015912:Thrombolytic Therapy; D016896:Treatment Outcome