[Effect of captopril on the nervous function in rabbits exposed to vibration].
OBJECTIVE
To study the effect of captopril on the nervous function in rabbits exposed to vibration.


METHODS
Rabbits were divided into vibration group, intervention group, and control group. Vibration group and intervention group were exposed to (tested by) vibration. Captopril was given to intervention group from the 11th day of vibration exposure. Somatosensory evoked potential (SEP) and motor nervous conduction function (MCF) were measured and analyzed in each group before and after vibration exposure.


RESULTS
The latent periods of N1, P1 and N2 of SEP in vibration group after vibration exposure were (30.76 +/- 4.26), (41.91 +/- 6.67), and (45.29 +/- 5.81) ms respectively, and in intervention group after vibration exposure were (27.00 +/- 3.04), (35.07 +/- 4.20) and (41.15 +/- 3.19) ms respectively. Compared with intervention group before and after exposure, and control group, the latent periods of each wave of SEP were delayed significantly (P < 0.05). The nervous conduction velocity, the distant wave amplitude, and the distant potential period of sciatic nerve in vibration group after vibration exposure were significantly different from those in intervention group [(35.69 +/- 4.37) m/s, (1.55 +/- 0.73) microV, (8.16 +/- 0.71) ms respectively vs (52.20 +/- 5.13) m/s, (2.89 +/- 0.36) microV, (7.26 +/- 0.77) ms respectively (P < 0.01)].


CONCLUSIONS
Captopril may improve the impairment of nervous functions to a certain degree in rabbits exposed to vibration.
Lin
Li
L
Institute for Occupational Health and Environmental Medicine, Preventive Medicine Department of Jining Medical College, Jining 272013, China.
Zhang
Kai
K
Zhang
Chun-zhi
CZ
Zhang
Jing
J
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D011817:Rabbits; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D014732:Vibration / Q000009:adverse effects*
D002216:Captopril