title: ASPP--Apoptotic specific regulator of p53.
abstract: The p53 protein is one of the best-known tumor suppressors. The recently identified ASPP family (apoptosis-stimulating protein of p53) can interfere with the working of p53. Three members of ASPP family are proved to be apoptotic specific regulators of p53. The discovery of ASPP family may answer such questions as "how cells choose to die". Understanding the ASPP status in human cancer will allow us to develop better strategies to treat cancer.
authors.affiliation: Laboratory of International Cooperation, Southwest Hospital, Third Military Medical University, Chongqing 400038, PRC. a65424208@cta.cq.cn
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins / Q000502:physiology*; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C498406:PPP1R13B protein, human; C119612:PPP1R13L protein, human; D012097:Repressor Proteins; C090468:TP53BP2 protein, human; D016159:Tumor Suppressor Protein p53