The IL-1 gene family and bone involvement in celiac disease.
Celiac disease (CD) is associated with decreased bone mineral mass. Its pathogenesis is multifactorial since both systemic and local mechanisms may play a role. Our objective was to determine whether single-nucleotide polymorphisms in genes encoding members of the interleukin-1 family are associated with bone damage measured by densitometry in a series of 71 adult CD patients assessed at diagnosis. When compared with non-carrier CD patients, carriers of allele T of the interleukin-1beta gene (IL1B-511T) had a significantly lower bone mass at the total skeleton level (p = 0.0484) and a greater prevalence of osteopenia/osteoporosis (p = 0.0102). To our knowledge, this is the first evidence on the association between a genetic predisposition and low bone mass in CD patients. This finding supports the postulated inflammation-associated bone loss pathogenesis as one of the causes of bone weakness in CD.
Moreno
M L
ML
Department of Medicine, C. Bonorino Udaondo Gastroenterology Hospital, Buenos Aires, Argentina.
Crusius
J B A
JB
Cherñavsky
A
A
Sugai
E
E
Sambuelli
A
A
Vazquez
H
H
Mauriño
E
E
Peña
A S
AS
Bai
J C
JC
D000328:Adult; D000368:Aged; D015519:Bone Density; D002446:Celiac Disease / Q000150:complications* / Q000235:genetics*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*; D020641:Polymorphism, Single Nucleotide
D007375:Interleukin-1