title: Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents.
abstract: A series of dihydropyrido[2,3-d]pyrimidines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a-2l have shown 83-100% inhibition against promastigotes and 79-100% inhibition against amastigotes at a concentration of 50 microg/mL.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Anu
authors.initials: A
authors.lastname: Agarwal
authors.lastname: Ramesh
authors.lastname: Ashutosh
authors.forename: Neena
authors.initials: N
authors.lastname: Goyal
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D006859:Hydrogen / Q000737:chemistry; D007891:Leishmania / Q000187:drug effects*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D011743:Pyrimidines; D006859:Hydrogen