title: Aggressive spinal germinoma with ascending metastases.
abstract: We report the case of a 28-year-old young man who presented with progressive paraparesis and urinary incontinence. Initial spinal MR scans showed a sausage-like lesion that extended between L1 and S2. At surgery, an encapsulated intradural extramedullary tumor was removed en bloc. The initial histopathological diagnosis was ependymoma. The tumor recurred locally to double its original size only 4 months later. After second surgery, 5,100 cGy of local spinal radiation was given since the pathologist believed that the new tumor exhibited anaplastic features. Subsequently tumor recurred at T6-10 levels and later in the right parasellar region. Surgery was undertaken for both recurrences and radiation to whole spine and to whole brain respectively followed surgery. At 11 months after the initial presentation, a new tumor was diagnosed at T11-T12 levels. After fifth surgery, chemotherapy with cisplatin, doxorubicin and vincristine was started. At this stage, review of all five surgical specimens by an outside neuropathologist was considered crucial. The new and correct histological diagnosis was germinoma. A new chemotherapy regimen targeted for germinoma was then started. The patient remains alive with no evidence of disease at 22 months after initial presentation. Primary spinal germinomas are exceedingly rare. A review of the literature revealed only 14 biopsy-proven spinal germinoma cases. Our case is clearly unique in aggressivity of the tumor, a feature often unexpected for germinomas. This case proves that the dissemination risk may be very serious for germinomas and that the craniospinal radiation may be a more secure treatment mode.
authors.affiliation: Mersin University School of Medicine, Mersin, Turkey. itekok@mesa.com.tr
authors.forename: Ismail H
authors.initials: IH
authors.lastname: Tekkök
authors.forename: Aydin
authors.initials: A
authors.lastname: Sav
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000175:diagnosis; D005500:Follow-Up Studies; D018237:Germinoma / Q000175:diagnosis* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008159:Lumbar Vertebrae / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D012086:Reoperation; D012447:Sacrum / Q000033:anatomy & histology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome