BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice.
BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.
Hardy
Britta
B
Felsenstein Medical Research Center, Tel Aviv University School of Medicine, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel. bhardy@post.tau.ac.il
Morgenstern
Sara
S
Raiter
Annat
A
Rodionov
Galina
G
Fadaeev
Ludmilla
L
Niv
Yaron
Y
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D017690:Cell Transplantation; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D007167:Immunotherapy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice
D000911:Antibodies, Monoclonal