[Expression of serum hepatocyte growth factor in patients with acute renal failure].
OBJECTIVE
To investigate the changes of serum hepatocyte growth factor (HGF) in patients with acute renal failure (ARF) and to evaluate the clinical value.


METHODS
Serum HGF levels were determined by ELISA in 31 patients with ARF at the stages of oliguria, polyuria and convalescence and in 28 healthy controls.


RESULTS
Compared with the controls, the HGF levels in the serum increased significantly in the ARF group at the stages of oliguria and polyuria, while the serum HGF returned to normal levels at the convalescence stage. There was significant positive correlation between the serum HGF and BUN or SCr in the ARF group.


CONCLUSIONS
Serum HGF in ARF patients increased significantly and tended to rise at first but dropped afterwards, which reflected the course of renal injury and the recovery of renal epithelial cells.
Zhang
Jun
J
Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
Tao
Li-Jian
LJ
Hu
Zhao-Jun
ZJ
D058186:Acute Kidney Injury / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003289:Convalescence; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D017228:Hepatocyte Growth Factor