Hodgkin's disease as unusual presentation of post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for malignant glioma.
BACKGROUND
Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been reported. Here, a case of Hodgkin's disease (HD), as unusual presentation of PTLD after autologous HSCT for malignant glioma is described.


METHODS
60-years old man affected by cerebral anaplastic astrocytoma underwent subtotal neurosurgical excision and subsequent high-dose chemotherapy followed by autologous HSCT. During the post HSCT course, cranial irradiation and corticosteroids were administered as completion of therapeutic program. At day +105 after HSCT, the patient developed HD, nodular sclerosis type, with polymorphic HD-like skin infiltration.


CONCLUSIONS
The clinical and pathological findings were consistent with the diagnosis of PTLD.
Zambelli
Alberto
A
U.O. di Oncologia Medica I, IRCCS, Fondazione Salvatore Maugeri, Pavia, Italy. azambelli@fsm.it
Lilleri
Daniele
D
Baldanti
Fausto
F
Scelsi
Mario
M
Villani
Laura
L
Da Prada
Gian Antonio
GA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005910:Glioma / Q000150:complications / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008207:Lymphatic Metastasis; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous / Q000009:adverse effects*
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents