title: New plastoquinones isolated from the brown alga, Sargassum micracanthum.
abstract: Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University; 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Mori
authors.forename: Makoto
authors.initials: M
authors.lastname: Iwashima
authors.forename: Hiroko
authors.initials: H
authors.lastname: Wakasugi
authors.forename: Haruo
authors.initials: H
authors.lastname: Saito
authors.forename: Takayuki
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Masaru
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hideyo
authors.initials: H
authors.lastname: Suzuki
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002725:Chloroform; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D006834:Hydrazines / Q000737:chemistry; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D000432:Methanol; D051379:Mice; D009249:NADP / Q000737:chemistry; D010084:Oxidation-Reduction; D000459:Phaeophyceae / Q000737:chemistry*; D010851:Picrates; D011809:Quinones / Q000737:chemistry*; D051381:Rats; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D011809:Quinones; D012997:Solvents; D009249:NADP; D002725:Chloroform; C004931:1,1-diphenyl-2-picrylhydrazyl; D000432:Methanol