[TGF-beta1 in allograft and long-term renal function].
OBJECTIVE
To determine the relation between transforming growth factor beta1 (TGF-beta1) in allograft and long-term renal function.


METHODS
Urine TGF-beta1 relative concentration (divided by urine creatinine) was tested in 168 recipients whose renal function was normal between August 1, 2000 and March 31, 2001. Twenty patients with higher urine TGF-beta1 relative concentrations formed Group A, and another 20 patients with lower urine TGF-beta1 formed Group B. In both groups biopsies were carried out in 15 cases and 12 cases respectively, and TGF-beta1 in the biopsis was tested by immunofluorescence. Blood TGF-beta1 concentrations in the 2 groups were also tested. Three years later, the renal function was compared between the 2 groups. Biopsies were carried out in renal recipients whose creatinine was higher than that of the normal.


RESULTS
Blood TGF-beta1 concentrations in the 2 groups were not different significantly; 3 years after the transplantation, there was more loss of renal function and more chronic allograft nephropathy (CAN) cases in Group A than in Group B. Expression of TGF-beta1 in the allografts was higher in Group A than in Group B. The differences in the 2 groups were significant.


CONCLUSIONS
The findings suggest that the higher expression of TGF-beta1 in the allografts is associated with the lower long-term survival rate of kidney graft. The level of urine TGF-beta1 after the renal transplantation can predict the long-term renal function.
Wang
Ping-xian
PX
Department of Urology, Second Affiliated Hospital, Third Military Medical University, Chongqing 400037, China.
Huang
Xiu-ying
XY
Wang
An-jing
AJ
Huang
Chi-bing
CB
Fan
Ming-qi
MQ
Zhang
Yin-pu
YP
D001707:Biopsy, Needle; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology* / Q000652:urine; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000503:physiopathology / Q000652:urine; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000652:urine*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1