[IFN-gamma in tear fluid in patients with cystic fibrosis].
OBJECTIVE
To evaluate IFN-gamma concentration in tear fluid in CF patients.


METHODS
Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA.


RESULTS
The concentration of IFN-gamma in tear fluid in CF patients was 10.75+/-2.23 pg/ml, and 4.06+/-0.57 pg/ml in control group.


CONCLUSIONS
The results of this study indicate that increased concentration of IFN-gamma in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.
Mrugacz
Małgorzata
M
Z Kliniki Okulistyki Dzieciecej Akademii Medycznej w Białymstoku.
Zelazowska
Beata
B
Bakunowicz-Lazarczyk
Alina
A
Wysocka
Jolanta
J
Minarowska
Alina
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D008297:Male; D013666:Tears / Q000737:chemistry*
D007371:Interferon-gamma