title: A microfabrication method of a biodegradable polymer chip for a controlled release system.
abstract: A simple microfabrication method for a controlled-release drug-delivery system has been designed using biodegradable polymeric microchips. Microholes were made in a poly(L-lactic acid) plate and dyes were cast in each well. After drying, the wells were sealed with polymers having different biodegradation rates using a mold that had hollows corresponding to the wells. The polymers were prepared by mixing polylactides with the co-polymers. The sealing was confirmed by ultrasonication. The plate was incubated in phosphate-buffered saline and the dye released from the plate as the degradation proceeded was detected spectrophotometrically. The higher the degradation rate of the polymer sealing, the faster the sealed dye was released. This biodegradable biochip is useful for the design of controlled-release drug-delivery systems.
authors.affiliation: Kanagawa Academy of Science and Technology, KSP East 309, 3-2-1 Sakado, Takatsu-ku, Kawasaki, 213-0012, Japan. y-ito@ksp.or.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Hasuda
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Morimatsu
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takagi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hirai
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)