title: Homocysteine and schizophrenia: from prenatal to adult life.
abstract: Homocysteine is becoming increasingly recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia. In this review, we first present background information supporting a role for homocysteine in schizophrenia. We then discuss our work on the role of hyperhomocystinemia during adulthood and risk of schizophrenia, and present preliminary evidence on a potential relationship between prenatal homocysteine and schizophrenia. Finally, we discuss the implications of these findings for future work on nutritional etiologies of schizophrenia.
authors.affiliation: College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA. asb11@columbia.edu
authors.forename: Alan S
authors.initials: AS
authors.lastname: Brown
authors.forename: Ezra S
authors.initials: ES
authors.lastname: Susser
mesh_terms: D005260:Female; D006711:Homocystine / Q000378:metabolism*; D006801:Humans; D008297:Male; D010290:Parents; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012306:Risk; D012559:Schizophrenia / Q000378:metabolism*; D012565:Schizophrenic Psychology
chemical_list: D006711:Homocystine