Microtubule motors: LSD2 trips the toggle.
The Perilipin homologue LSD2 has been identified as a regulator of microtubule motor activity in Drosophila embryos. LSD2 is required for the net directional transport of lipid droplets and the new data support a model in which the protein imparts bias onto a molecular toggle that otherwise randomly engages minus and plus end motors in a paired set.
Cohen
Robert S
RS
Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, USA. rcohen@ku.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins; D004330:Drosophila / Q000196:embryology / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D026901:Membrane Transport Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000378:metabolism*
D002352:Carrier Proteins; D029721:Drosophila Proteins; D026901:Membrane Transport Proteins; D020409:Molecular Motor Proteins; D000070778:Perilipin-1; D010750:Phosphoproteins; C401521:klar protein, Drosophila