Efficient pd-catalyzed amination of heteroaryl halides.
The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine. [reaction: see text]
Charles
Mark D
MD
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Schultz
Phillip
P
Buchwald
Stephen L
SL
D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry
D006846:Hydrocarbons, Halogenated; D010720:Phosphines; D011743:Pyrimidines; D010165:Palladium