[Detection of genital tract cytomegalovirus and Chlamydia trachomatis infection in patients with tubal pregnancy].
OBJECTIVE
To investigate the influence of genital tract cytomegalovirus and chlamydia infection on the incidence of tubal pregnancy.


METHODS
Ninety-five women with tubal pregnancy (study group) and 42 women with ovarian cysts (control group) were selected for this study. Serum cytomegalovirus (CMV) IgM was identified by enzyme-link-immunosorbent-assay (ELISA). Cervical secretions, endometrium, and salpinx tissue were tested for CMV gH gene and chlamydia heat shock protein (HSP) gene by nest polymerase chain reaction (PCR) and PCR respectively.


RESULTS
CMV IgM was positive in 14 (15%) women with tubal pregnancy, and 1 (2%) in the control group. CMV gH gene was detected in 18 women (19%) and chlamydia HSP gene in 25 (26%) of the tubal pregnancy group, and 2 (5%) and 2 (5%) in the control group respectively. There were significant differences between the study and the control group (P < 0.05) with respect to detection of CMV IgM, CMV gH gene and chlamydia HSP gene.


CONCLUSIONS
CMVand chlamydia trachomatis genital tract infection were more common in women with tubal pregnancy than that in the control group. Genital CMV and chlamydia trachomatis infection may associate with an increased incidence of tubal pregnancy.
Jin
H
H
Department of Gynecology, Women's Hospital, Medical School of Zhejiang University, Hangzhou 310006, China.
Lin
J
J
Xu
K
K
D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification*; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005814:Genes, Viral; D005831:Genital Diseases, Female / Q000150:complications*; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D007075:Immunoglobulin M; D015994:Incidence; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011274:Pregnancy, Tubal / Q000453:epidemiology / Q000821:virology*
D000914:Antibodies, Viral; D006360:Heat-Shock Proteins; D007075:Immunoglobulin M