Biochemical mechanisms of thyroid hormone deiodination.
Deiodination is the foremost pathway of thyroid hormone metabolism not only in quantitative terms but also because thyroxine (T(4)) is activated by outer ring deiodination (ORD) to 3,3',5-triiodothyronine (T(3)), whereas both T(4) and T(3) are inactivated by inner ring deiodination (IRD) to 3,3',5-triiodothyronine and 3,3'-diiodothyronine, respectively. These reactions are catalyzed by three iodothyronine deiodinases, D1-3. Although they are homologous selenoproteins, they differ in important respects such as catalysis of ORD and/or IRD, deiodination of sulfated iodothyronines, inhibition by the thyrostatic drug propylthiouracil, and regulation during fetal and neonatal development, by thyroid state, and during illness. In this review we will briefly discuss recent developments in these different areas. These have resulted in the emerging view that the biological activity of thyroid hormone is regulated locally by tissue-specific regulation of the different deiodinases.
Kuiper
George G J M
GG
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Kester
Monique H A
MH
Peeters
Robin P
RP
Visser
Theo J
TJ
D000595:Amino Acid Sequence; D000818:Animals; D002384:Catalysis; D020134:Catalytic Domain; D015971:Gene Expression Regulation, Enzymologic; D014644:Genetic Variation; D006801:Humans; D007453:Iodide Peroxidase / Q000737:chemistry* / Q000235:genetics; D008956:Models, Chemical; D008969:Molecular Sequence Data; D010802:Phylogeny; D011441:Propylthiouracil / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D013959:Thyroid Diseases / Q000378:metabolism; D013963:Thyroid Hormones / Q000737:chemistry*; D013974:Thyroxine / Q000737:chemistry; D014018:Tissue Distribution; D014284:Triiodothyronine / Q000737:chemistry
D013963:Thyroid Hormones; D014284:Triiodothyronine; D011441:Propylthiouracil; D007453:Iodide Peroxidase; D013974:Thyroxine