Chip-based microelectrodes for detection of single-nucleotide mismatch.
Microelectrode arrays having eight 10-microm-diameter gold microelectrodes arranged on a gold-covered Si chip were designed and characterized. The chips prove useful for the detection of single-nucleotide mismatches in unlabeled and prehybridized DNA by electrochemical impedance spectroscopy.
Li
Xiaohong
X
Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
Zhou
Yinglin
Y
Sutherland
Todd C
TC
Baker
Brian
B
Lee
Jeremy S
JS
Kraatz
Heinz-Bernhard
HB
D020137:Base Pair Mismatch / Q000235:genetics*; D004247:DNA / Q000032:analysis* / Q000235:genetics; D004563:Electrochemistry; D008839:Microelectrodes; D009711:Nucleotides / Q000032:analysis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*
D009711:Nucleotides; D004247:DNA