Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides.
Two new sesquiterpenes, 10beta-methoxymuurolan-4-en-3-one (1) and 10alpha-methoxycadinan-4-en-3-one (2), were isolated from the root bark of Zanthoxylum ailanthoides. The structures of 1 and 2 were elucidated from spectroscopic data. Sixty-seven compounds obtained from the root bark of the same plant were evaluated for inhibition of HIV replication in H9 lymphocyte cells, and 14 compounds demonstrated significant activity. Among them, decarine, gamma-fagarine, and (+)-tembamide were the most potent anti-HIV compounds, with EC50 values of <0.1 microg/mL and TI values of >226, >231, and >215, respectively.
Cheng
Ming-Jen
MJ
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, 807 Kaohsiung, Taiwan, ROC.
Lee
Kuo-Hsiung
KH
Tsai
Ian-Lih
IL
Chen
Ih-Sheng
IS
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D032106:Zanthoxylum / Q000737:chemistry*
C506390:10alpha-methoxycadinan-4-en-3-one; C506389:10beta-methoxymuurolan-4-en-3-one; D019380:Anti-HIV Agents; D012717:Sesquiterpenes