title: Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data.
abstract: The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS.
authors.affiliation: Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK.
authors.forename: J
authors.initials: J
authors.lastname: Sastre-Garriga
authors.forename: G T
authors.initials: GT
authors.lastname: Ingle
authors.forename: M
authors.initials: M
authors.lastname: Rovaris
authors.forename: N
authors.initials: N
authors.lastname: Téllez
authors.forename: B
authors.initials: B
authors.lastname: Jasperse
authors.forename: D R
authors.initials: DR
authors.lastname: Altmann
authors.forename: B
authors.initials: B
authors.lastname: Benedetti
authors.forename: V L
authors.initials: VL
authors.lastname: Stevenson
authors.forename: M
authors.initials: M
authors.lastname: Cercignani
authors.forename: S M
authors.initials: SM
authors.lastname: Leary
authors.forename: F
authors.initials: F
authors.lastname: Barkhof
authors.forename: B
authors.initials: B
authors.lastname: Brochet
authors.forename: V
authors.initials: V
authors.lastname: Dousset
authors.forename: M
authors.initials: M
authors.lastname: Filippi
authors.forename: X
authors.initials: X
authors.lastname: Montalban
authors.forename: N F
authors.initials: NF
authors.lastname: Kalkers
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
authors.forename: A
authors.initials: A
authors.lastname: Rovira
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
mesh_terms: D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002490:Central Nervous System / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D003625:Data Collection; D038524:Diffusion Magnetic Resonance Imaging / Q000592:standards; D004185:Disability Evaluation; D018450:Disease Progression; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data*; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors