title: Timing of fixation of major fractures in blunt polytrauma: role of conventional indicators in clinical decision making.
abstract: Grading of the clinical status in patients with multiple trauma is important regarding the treatment plan. In recent years, 4 different clinical conditions have been described: stable, borderline, unstable, in extremis. Clinical parameters have been widely used in patients with penetrating injuries, and 3 categories were found to be important: shock, hypothermia, coagulopathy. However, in blunt trauma patients, the role of conventional parameters for decision making regarding the timing of fracture treatment is poorly described. After blunt trauma, additional factors seem to play a role, because the injuries affect multiple body regions. These additional factors are summarized under the term, "soft-tissue injuries," which may include the soft tissues of the extremities, lung, abdomen, and pelvis. The study describes four pathophysiologic cascades that are relevant to the clinical conditions listed above. Threshold values for separation of the patient conditions are documented, leading to a staged surgical strategy.
authors.affiliation: Department of Trauma Surgery, Hannover Medical School, Hannover, Germany.
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Pape
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
authors.forename: Christian
authors.initials: C
authors.lastname: Krettek
authors.forename: Otmar
authors.initials: O
authors.lastname: Trentz
mesh_terms: D003657:Decision Making; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005592:Fracture Fixation; D006801:Humans; D009104:Multiple Trauma / Q000145:classification / Q000150:complications / Q000503:physiopathology; D012771:Shock, Hemorrhagic / Q000145:classification / Q000150:complications / Q000503:physiopathology; D017695:Soft Tissue Injuries / Q000150:complications*; D013997:Time Factors; D014949:Wounds, Nonpenetrating / Q000145:classification / Q000150:complications / Q000503:physiopathology