Actin and myosin I in the nucleus: what next?
Several recent publications have demonstrated the importance of nuclear actin and nuclear myosin I in transcription. Here we review these publications and their implications. In addition, we discuss some important issues that should be addressed to gain a more comprehensive understanding of how these traditionally 'cytoplasmic' proteins are involved in transcription. We propose highly speculative models and mechanisms solely to stimulate thought and experimentation in this area.
de Lanerolle
Primal
P
the Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA. primal@uic.edu
Johnson
Terazina
T
Hofmann
Wilma A
WA
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006801:Humans; D024461:Myosin Type I / Q000378:metabolism*; D014158:Transcription, Genetic
D000199:Actins; D012321:DNA-Directed RNA Polymerases; D024461:Myosin Type I