title: Management of malignant tumors of the anterior and anterolateral skull base.
abstract: OBJECTIVE
  Malignant tumors of the skull base represent a group of diverse and infrequent lesions. Comprehensive oncological management requires a multidisciplinary team of neurological surgeons, otolaryngologists, radiation oncologists, plastic surgeons, and medical oncologists. The authors describe an institutional experience in performing 54 combined anterior-anterolateral cranial base resections for malignant disease.
  
  
  METHODS
  The technical considerations for preoperative workup, surgical approach, resection, and reconstruction are outlined and illustrated. Considerations for complication management and avoidance are detailed.
  
  
  CONCLUSIONS
  Overall mortality (0%) and morbidity rates (18%) are acceptable. The influence on the natural history of the disease process is an ongoing study.
authors.affiliation: Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois, USA. torigit@lumc.edu
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Origitano
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Petruzzelli
authors.forename: Darl
authors.initials: D
authors.lastname: Vandevender
authors.forename: Bahman
authors.initials: B
authors.lastname: Emami
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D019090:Case Management; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003399:Craniotomy / Q000379:methods; D005004:Ethmoid Bone; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D038361:Neuronavigation; D009669:Nose Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011300:Preoperative Care; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal; D019292:Skull Base Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D013524:Surgical Flaps; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents