Effect of curcumin on immune function of mice.
To investigate the effect of curcumin on immune function of mice, the effect of curcumin was examined on the proliferation of spleen lymphocytes of mice and the function of phagocytosis of peritoneal macrophage by using MTT test and the expression of the nucleoprotein of NFkappaB p65 was determined in spleen lymphocytes by employing Western Blot. Our results showed that curcumin could enhance the phagocytosis of peritoneal macrophages. Lowdose curcumin could upregulate the proliferation of spleen lymphocytes of mice, and highdose curcumin could suppress the proliferation of spleen lymphocytes. Curcumin could suppress the expression of NFkappaB p65. Our study suggested that curcumin can regulate immune function of mice in a dosedependent manner. The possible underlying mechanism might be its ability to suppress the activity of NFkappaB p65.
Li
Xinjian
X
Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Liu
Xiaocheng
X
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects; D013154:Spleen / Q000166:cytology*; D051996:Transcription Factor RelA / Q000378:metabolism
D000276:Adjuvants, Immunologic; D051996:Transcription Factor RelA; D003474:Curcumin