[Effect of ulinastatin on human blood coagulation and platelet aggregation in orthopaedic surgery].
OBJECTIVE
To investigate the effect of ulinastatin (UTI) on human blood coagulation and platelet aggregation in orthopaedic surgery.


METHODS
Thirty ASA I-II patients without blood dyscrasia and blood coagulation obstacle were randomly divided into two groups: Group I (UTI group, n=15) in which patients received UTI 5000 U/kg, and Group II (control group, n=15) in which patients received NS 100 ml. PT, TT, APTT, IB, INR and PAG1, PAG5, and PAGM were measured at 3 points: pre-infusion (T0), 1 hour after the infusion (T1), and 2 hours after the infusion (T2).


RESULTS
Compared with the saline group, APTT and PT of UTI group were prolonged significantly than the baseline (before infusion). In Group I, after the infusion, APT, TT and PT were prolonged significantly than before the infusion.


CONCLUSIONS
UTI 5000 U/kg can ameliorate orthopaedic patients and blood coagulation status,which may reduce microthrombus syndrome in the operation and prevent venous thrombosis after the operation.
Zou
Wang-yuan
WY
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. zwyfeng@163.com
Guo
Qu-lian
QL
Cai
Jin
J
Luo
He-guo
HG
D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011183:Postoperative Complications / Q000517:prevention & control; D014361:Trypsin Inhibitors / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000517:prevention & control*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin