DNA damage initiates photobiologic reactions in the skin.
Ultraviolet (UV) radiation can induce acute and chronic photobiologic reactions in the absence of exogenous chromophores. Nuclear DNA is a major chromophore to initiate UV-induced physiologic reactions. The XPA-gene deficient mouse, an animal model of xeroderma pigmentosum, develops increased photobiologic reactions including acute inflammation, immunosuppression and skin cancers, because of the defect in the excision repair of UV-induced DNA lesions.
Horio
Takeshi
T
Department of Dermatology, Kansai Medical University, Moriguchi, Osaka 570-8507, Japan. horio@takii.kmu.ac.jp
Miyauchi-Hashimoto
Hiroko
H
Okamoto
Hiroyuki
H
D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D006801:Humans; D012867:Skin / Q000528:radiation effects*; D013471:Sunburn / Q000503:physiopathology; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000503:physiopathology