Potential mutagenicity, embryotoxicity, and teratogenicity of calcium ketopantoyl aminobutyrate.
We studied mutagenic, embryotoxic, and teratogenic properties of calcium ketopantoyl aminobutyrate, a preparation proposed as a new drug. Long-term oral administration of calcium ketopantoyl aminobutyrate produced no mutagenic, embryotoxic, and teratogenic effects.
Karaev
A L
AL
Laboratory of Pharmacology, State Research Institute of Vitamins, Russian Academy of Medical Sciences, Moscow, Russia.
Treshchalin
I D
ID
Bodyagin
D A
DA
Pereverzeva
E R
ER
Kozlova
G S
GS
Gunar
V I
VI
Revazova
Yu A
YA
Yurchenko
V V
VV
D000014:Abnormalities, Drug-Induced; D000613:Aminobutyrates / Q000633:toxicity*; D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D018697:Nootropic Agents / Q000633:toxicity*; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D011247:Pregnancy
D000613:Aminobutyrates; D009153:Mutagens; D018697:Nootropic Agents; C504809:ketopantoyl aminobutyric acid; D010205:Pantothenic Acid