title: Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism.
abstract: One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.
authors.affiliation: Department of Neuropsychiatry, Hallym University Han-Gang Sacred Heart Hospital, Seoul, Republic of Korea.
authors.forename: Ihn-Geun
authors.initials: IG
authors.lastname: Choi
authors.forename: Baik Seok
authors.initials: BS
authors.lastname: Kee
authors.forename: Hyun-Gyun
authors.initials: HG
authors.lastname: Son
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Ham
authors.forename: Byung-Hwan
authors.initials: BH
authors.lastname: Yang
authors.forename: Seok Hyeon
authors.initials: SH
authors.lastname: Kim
authors.forename: Jun-Suk
authors.initials: JS
authors.lastname: Lee
authors.forename: Bong Ki
authors.initials: BK
authors.lastname: Son
authors.forename: Byeong-Yong
authors.initials: BY
authors.lastname: Lee
authors.forename: Sang-Yeol
authors.initials: SY
authors.lastname: Lee
authors.forename: Young-Gyu
authors.initials: YG
authors.lastname: Chai
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D004247:DNA / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005190:Family; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D007723:Korea / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D007527:Isoenzymes; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase