title: Effect of iontophoretical application of NK1 receptor antagonists on pulpal blood flow in cats.
abstract: The influence of NK1 receptor antagonists applied iontophoretically on pulpal blood flow (PBF) was investigated. Along with substance P (SP, 0.8 approximately 20.0 ng/kg) administration to the canine pulp through the catheterized lingual artery, two NK1 receptor antagonists, [D-Pro2,D-Trp7,9]-SP and [D-Pro2,D-Phe7,D-Trp9]-SP (0.2 approximately 3.4 mM) were applied iontophoretically (cathodal current, 0.02 approximately 0.1 mA, 1 min) to the prepared class V dentinal cavity of ipsilateral teeth in 11 generally anesthetized cats. A paired t-test showed that SP administration caused significant increases of PBF (p < 0.05) without changing systemic blood pressure, and that SP and SP antagonist administration caused significantly less increase of PBF than in control of SP and 0.9% saline administration (p < 0.05). These data provide evidence that the iontophoretic application of NK1 receptor antagonists effectively attenuates SP-induced vasodilatation and show the possibility of their use in the control of neurogenic inflammation in the dental pulp.
authors.affiliation: Department of Conservative Dentistry, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Young-Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Wan-sik
authors.initials: WS
authors.lastname: Chu
authors.forename: Ho-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Dong-Kuk
authors.initials: DK
authors.lastname: Ahn
authors.forename: Sung Kyo
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000818:Animals; D002415:Cats; D003782:Dental Pulp / Q000098:blood supply*; D007478:Iontophoresis; D064729:Neurokinin-1 Receptor Antagonists; D012039:Regional Blood Flow / Q000187:drug effects; D013373:Substance P / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D064729:Neurokinin-1 Receptor Antagonists; D014662:Vasoconstrictor Agents; D013373:Substance P