title: Hemorheological and cerebroprotective activity of Lychnis chalcedonica L. extract in rats with cerebral ischemia.
abstract: Considerable hemorheological changes and depression of EEG parameters were revealed in rats with cerebral ischemia. Course peroral treatment with scarlet lightning extract in a daily dose of 150 mg/kg for 5 days reduced the severity of hemorheological disorders. It manifested in a decrease in whole blood viscosity, plasma viscosity, erythrocyte aggregation, and fibrinogen concentration and increase in deformability. The extract of lightning extract improved EEG activity in rats with cerebral ischemia.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. oal@pharm.tsu.ru
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.forename: A S
authors.initials: AS
authors.lastname: Vasilev
authors.forename: M Yu
authors.initials: MY
authors.lastname: Maslov
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: L N
authors.initials: LN
authors.lastname: Zibareva
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D001921:Brain / Q000098:blood supply* / Q000187:drug effects / Q000502:physiology; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy*; D004569:Electroencephalography / Q000187:drug effects; D018056:Hemorheology; D031244:Lychnis / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D029751:Silene
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; C504810:scarlet lightning extract