Clinical significance of Acinetobacter species isolated from cerebrospinal fluid.
Medical records of 54 patients whose cerebrospinal fluid (CSF) cultures were positive for Acinetobacter were retrospectively reviewed. In 34 (63.0%) patients, the Acinetobacter isolates were clinically insignificant. In the other 20 (37.0%) patients, presence of the organism was regarded as clinically significant and specific antimicrobial therapy was administered. Patients with clinically significant Acinetobacter in CSF more frequently resided in intensive care units (p = 0.011), had intracerebral hemorrhage (p = 0.012) or previous CNS infection (p = 0.003), had prior antibiotic exposure (p = 0.011), and had undergone neurosurgical procedures (p = 0.003). Their CSF was characteristic of neutrophilic pleocytosis, an elevated protein level, and a low CSF-to-serum glucose ratio. Apart from fever, no significant statistical differences existed in individual clinical symptoms and signs between the 2 groups of patients, while a combination of symptoms efficiently differentiated clinically significant and insignificant Acinetobacter. The finding of multiple CSF specimens positive for Acinetobacter was highly suggestive of an active CNS infection (p<0.001). The high ratio of clinically insignificant Acinetobacter CSF isolates highlights the importance of careful judgment when the organism is cultured from CSF. Antimicrobial therapy must be initiated promptly in patients with identified risk factors, while unnecessary treatment should be avoided in those without them.
Chen
Hsin-Pai
HP
Department of Medicine, Su-Ao Veterans Hospital, Yilan.
Lai
Chung-Hsu
CH
Chan
Yu-Jiun
YJ
Chen
Te-Li
TL
Liu
Chun-Yu
CY
Fung
Chang-Phone
CP
Liu
Cheng-Yi
CY
D000150:Acinetobacter / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity*; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D012307:Risk Factors
D000900:Anti-Bacterial Agents