Effects of scalpel (with and without tissue adhesive) and cryosurgery on wound healing in rat tongues.
OBJECTIVE
To evaluate wound healing of incisions created by steel scalpel (with and without the application of N-butyl-2-cyanoacrylate) and cryosurgery.


METHODS
Prospective blinded and randomized study. Adult albino rats (N = 93) were randomly assigned to 3 groups (31 animals per group) before making incisions on oral mucosa by steel scalpel (2 groups) or cryosurgical techniques (remaining group). No product was applied to the resulting wound in the first group, while N-butyl-2-cyanoacrylate was applied to the wounds made in the tongues of the second group. Hemostasis, postoperative oral intake, and wound healing were measured. Statistical analysis was performed using analysis of variance.


RESULTS
The wounds to which N-butyl-2-cyanoacrylate had been applied showed no hemorrhaging and faster reepithelialization and resolution of the inflammatory response, and the animals gained weight more rapidly.


CONCLUSIONS
N-butyl-2-cyanoacrylate is a good hemostatic for managing wounds in the oral mucosa provoked by steel scalpel.
Camacho-Alonso
Fabio
F
University of Murcia, Murcia, Spain. fabiosurgery@hotmail.com
López-Jornet
Pía
P
Bermejo-Fenoll
Ambrosio
A
D000704:Analysis of Variance; D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control; D003452:Cryosurgery; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use*; D008297:Male; D009584:Nitrogen; D019647:Oral Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014059:Tongue / Q000601:surgery*; D015430:Weight Gain; D014945:Wound Healing
D006490:Hemostatics; D014014:Tissue Adhesives; D004659:Enbucrilate; D009584:Nitrogen