Synthesis of melanin pigment by Candida albicans in vitro and during infection.
Melanins are implicated in the pathogenesis of several important human diseases. This study confirmed the presence of melanin particles in Candida albicans in vitro and during infection. Dark particles were isolated from the digestion of C. albicans cultures and from infected tissue, as established by electron microscopy and immunofluorescence techniques.
Morris-Jones
Rachael
R
St. John's Institute of Dermatology, St. Thomas' Hospital, London SE1 9RT, United Kingdom. themojos@boltblue.com
Gomez
Beatriz L
BL
Diez
Soraya
S
Uran
Martha
M
Morris-Jones
Stephen D
SD
Casadevall
Arturo
A
Nosanchuk
Joshua D
JD
Hamilton
Andrew J
AJ
D000818:Animals; D002176:Candida albicans / Q000378:metabolism* / Q000472:pathogenicity / Q000648:ultrastructure; D002177:Candidiasis / Q000378:metabolism* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D014774:Virulence
D008543:Melanins