title: [Dietary fatty acids and experimental carcinogenesis].
abstract: Experiments in animal models of mammary carcinogenesis suggest that fatty acids promote mammary tumors development. This effect depends first on the amount then on the type of fatty acids available. n-6 fatty acids such as linoleic acid generally stimulates mammary tumor growth, while n-3 fatty acids oppose this effect. Conjugated diene fatty acids (CLA) inhibit mammary carcinogenesis when brought at elevated amount. There are limitations in using an animal model in the analysis between nutrition and colorectal cancers. This is ascribable to the following: firstly, the digestive tract of rodents if different from that of humans and secondly, the induction of colon cancer in these animals (chemical carcinogenesis, injection of cancerous cells or transgenesis) does not mimic human colon carcinogenesis. However, on the basis of numerous published data, some important correlations have arisen that could generate hypotheses and guide new epidemiological/interventional and experimental studies. In these animal models it appears that an adequate supply of n-3 PUFAs and oleic acid in food may exert a protective effect at all stages of colon carcinogenesis. On the other hand, an excessive consumption of n-6 PUFAs and of saturated fatty acids could promote colon cancers.
authors.affiliation: Inserm E 0211, Equipe de recherche Nutrition, croissance et cancer, Corad, CHU de Tours 2, boulevard Tonnellé 37044 Tours Cedex.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bougnoux
authors.forename: Jean
authors.initials: J
authors.lastname: Menanteau
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000209:etiology; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D006801:Humans; D019787:Linoleic Acid / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology; D023421:Models, Animal; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology* / Q000517:prevention & control; D019301:Oleic Acid / Q000008:administration & dosage; D011471:Prostatic Neoplasms; D012377:Rodentia; D017962:alpha-Linolenic Acid / Q000008:administration & dosage
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D017962:alpha-Linolenic Acid; D019301:Oleic Acid; D019787:Linoleic Acid