[Investigational treatment of cancer using electrochemotherapy, electrochemoimmunotherapy and electro-gene transfer].
Electroporation is the use of short, high-voltage pulses to transiently permeabilize the cell membrane. This technique can be used to increase the cellular uptake of otherwise non-permeating molecules, e.g., cytotoxic agents (electrochemotherapy). The electrochemotherapy area can also be used as a tumorlysis product in connection with immunotherapy. New avenues are opening for the clinical use of electroporation in non-viral gene delivery.
Gehl
Julie
J
Herlev Amtssygehus, Onkologisk Afdeling, Herlev. juge@herlevhosp.kbhamt.dk
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004566:Electrodes; D018274:Electroporation / Q000379:methods*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008545:Melanoma / Q000188:drug therapy / Q000628:therapy*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000628:therapy*; D035703:Therapies, Investigational / Q000379:methods
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin