title: A genetic study of two calcium-independent cytosolic PLA2 genes in schizophrenia.
abstract: The present study detected 9 single nucleotide polymorphisms (SNPs) at the PLA2G4C and PLA2G6 loci among 240 Chinese parent-offspring trios of Han descent. Of these 9 SNPs, 5 showed highly polymorphic in the Chinese population. They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia. The transmission disequilibrium test (TDT) showed that rs1549637 at the PLA2G4C locus was the only SNP associated with the illness (chi(2) = 5.63, P = 0.018). The global P-value was 0.082 for 1000 permutations with the TDT analysis. Neither the conditional on allele test nor the conditional on genotype test showed a disease association for the combination of these two genes. Because the PLA2G4C association is so weak, this initial finding should be interpreted with caution.
authors.affiliation: Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.forename: Jieping
authors.initials: J
authors.lastname: Shi
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Changgui
authors.initials: C
authors.lastname: Kou
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Guo
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Xie
authors.initials: X
authors.lastname: Lin
authors.forename: Shuzheng
authors.initials: S
authors.lastname: Liu
authors.forename: Guizhi
authors.initials: G
authors.lastname: Ju
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003600:Cytosol / Q000201:enzymology*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D054522:Group VI Phospholipases A2; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D010741:Phospholipases A; D054522:Group VI Phospholipases A2; C516475:PLA2G6 protein, human; D054467:Phospholipases A2