[Changes and relations of soluble plasma CD40L and matrix metalloproteinase-9 levels in patients with coronary heart disease].
OBJECTIVE
To investigate the serum soluble CD40 ligand (sCD40L) levels in coronary heart disease and its relationship with MMP-9 and to explore the potential predicting factor for the acute coronary syndrome.


METHODS
Enzyme-linked immunosorbent assay was used to measure the sCD40L and MMP-9 in 79 patients with coronary heart disease.


RESULTS
sCD40L level was significantly higher in patients with acute coronary syndrome [(1.96 +/- 0.84) ng/ml and (2.23 +/- 0.99) ng/ml in unstable angina and acute myocardial infarction group, respectively] than in stable coronary heart disease patients [(1.20 +/- 0.76) ng/ml, P < 0.05]. Serum sCD40L was significantly correlated with MMP-9 (r = 0.401 , P < 0.01), and sCD40L level was significantly correlated with TG (r = 0.254, P = 0.039), HDL (r = -0.234, P = 0.031), and HDL-C (r = -0.253, P = 0.024).


CONCLUSIONS
Serum sCD40L and MMP-9 levels were elevated in acute coronary syndrome, suggesting the possible relation to the pathogenesis of ACS and it may serve as a potential marker of plaque stability.
Li
Jiang
J
Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. lij8898@medmail.com.cn
Zhao
Shui-ping
SP
Peng
Dao-quan
DQ
Zhou
Hong-nian
HN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000150:complications; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D015415:Biomarkers / Q000097:blood; D023201:CD40 Ligand / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications
D015415:Biomarkers; D023201:CD40 Ligand; D020780:Matrix Metalloproteinase 9