title: Calcium channel blockers, beta-blockers and digitalis poisoning: management in the emergency room.
abstract: Calcium channel blockers and beta-blockers intoxications account for up to 65% of deaths for cardiovascular drugs, causing severe clinical symptoms refractory to standard medications. The most serious poisonings are those resulting from verapamil and propanolol ingestion. Both support and antidotic therapy are necessary for these potentially unstable patients. Supportive measures and the use of digoxin-specific antibody fragments are first line treatment for digitalis glycoside poisoning.
authors.affiliation: Department of Emergency Medicine, Catholic University--Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Ojetti
authors.forename: A
authors.initials: A
authors.lastname: Migneco
authors.forename: F
authors.initials: F
authors.lastname: Bononi
authors.forename: A
authors.initials: A
authors.lastname: De Lorenzo
authors.forename: N
authors.initials: N
authors.lastname: Gentiloni Silveri
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004070:Digitalis / Q000506:poisoning*; D004077:Digoxin / Q000506:poisoning; D004632:Emergency Medical Services; D006801:Humans
chemical_list: D000319:Adrenergic beta-Antagonists; D000931:Antidotes; D002121:Calcium Channel Blockers; D004077:Digoxin