[Comparative efficacy of choline antagonists in chronic obstructive lung disease].
The efficacy of thiotropium bromide, 18 microg/day, versus ipratropium bromide, 160 microg/day, was studied in 20 patients with chronic obstructive lung disease (COLD) treated with a drug for 4 weeks. Clinical and spirographic parameters and arterial blood gas composition were determined. According to clinical and spirographic data, thiotropium bromide has some advantage over ipratropium. Both test drugs improved blood gas composition.
Pavlishchuk
S A
SA
Bolotova
E V
EV
D000280:Administration, Inhalation; D001784:Blood Gas Analysis; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D012602:Scopolamine Derivatives / Q000008:administration & dosage / Q000627:therapeutic use*; D013147:Spirometry; D000069447:Tiotropium Bromide; D016896:Treatment Outcome
D018680:Cholinergic Antagonists; D012602:Scopolamine Derivatives; D000069447:Tiotropium Bromide