Use of molecule imprinting-chemiluminescence method for the determination of tamoxifen in breast cancer sufferers' urine.
The reaction between soluble Mn(IV) and tamoxifen can produce chemiluminescence and formaldehyde can enhance this chemiluminescence reaction. A tamoxifen molecular imprinted polymer (MIP) was synthesized and its adsorption selectivity to tamoxifen in aqueous solution was evaluated. Using a synthesized tamoxifen MIP as the recognition material and a soluble Mn(IV)-formaldehyde-tamoxifen chemiluminesence system as the detection system, a new molecule imprinting-chemiluminesence method of determination of tamoxifen was established. The response range of this method was 1.0 x 10(-7)-6.0 x 10(-6) g/mL, with a linear correlation coefficient of 0.997. The detection limit was 4 x 10(-8) g/mL. The relative standard deviation for 5.0 x 10(-7) g/mL tamoxifen solution was 4.1% (n = 9).
Nie
Fei
F
School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China.
Lu
Jiuru
J
He
Yunhua
Y
Du
Jianxiu
J
D000327:Adsorption; D001943:Breast Neoplasms / Q000652:urine*; D005557:Formaldehyde; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D008345:Manganese / Q000737:chemistry; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013629:Tamoxifen / Q000737:chemistry* / Q000652:urine*; D013997:Time Factors
D011108:Polymers; D012996:Solutions; D013629:Tamoxifen; D005557:Formaldehyde; D008345:Manganese