title: Enantioselective synthesis of (+)(R)- and (-)(S)-nicotine based on Ir-catalysed allylic amination.
abstract: The synthesis of nicotine with enantiomeric excess of >99% ee was accomplished by asymmetric Ir-catalysed allylic amination followed by ring closing metathesis and racemization-free double bond reduction.
authors.affiliation: Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Welter
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Moreno
authors.forename: Stephane
authors.initials: S
authors.lastname: Streiff
authors.forename: Günter
authors.initials: G
authors.lastname: Helmchen