Drugging the undruggable.
In this issue of Chemistry and Biology, Li and Lawrence report an iterative synthesis/selection process to identify chemically modified peptide ligands possessing high affinity and selectivity for the SH3 domain of Fyn, a member of the Src kinase family.
Mayer
John P
JP
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. mayer_john_p@lilly.com
Dimarchi
Richard D
RD
D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D008024:Ligands; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D018909:src Homology Domains
D008024:Ligands; D010455:Peptides