[Correlation between the polymorphism of HLA-A, -B, and -DRB1 alleles and susceptibility to leukemia].
OBJECTIVE
To explore the correlation between the polymorphism of HLA-A, -B and -DRB1 alleles and susceptibility to leukemia in Chinese Han population, Gansu province.


METHODS
The polymorphism of HLA-A, -B and -DRB1 alleles in 57 patients with leukemia and 45 normal controls were determined by PCR with sequence-specific oligonucleotide probe (PCR-SSO).


RESULTS
The frequencies of allele HLA-A01, -B38, and -DR15 in patients with leukemia were higher than those in control group (P<0.05), while the frequencies of allele HLA-A11 and -DR03 notably decreased (P<0.05).


CONCLUSIONS
HLA-A01, -B38 and -DR15 alleles in Han population, Gansu province seem to contribute to the genetic susceptibility, while HLA-A11 and -DR03 alleles to the genetic resistance, to leukemia.
Zhou
Lan-xia
LX
Center Laboratory, First Hospital of Lanzhou University, Lanzhou 730000, China. lanxiazhou@hotmail.com
Zhao
Li
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D055815:Young Adult
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains