title: Effects of hysterectomy on ovarian morphology and serum FSH level in rats.
abstract: OBJECTIVE
  To investigate the effects of hysterectomy with ovarian conservation on ovarian histology and FSH plasma level.
  
  
  METHODS
  Fifty female Wistar albino rats (30 for hysterectomy and 20 sham operated for control) were used after two complete estrous cycles. Six months after hysterectomy, the blood samples were collected from both the groups to test FSH plasma level and all animals were sacrificed by decapitation to obtain ovaries for histological examination.
  
  
  RESULTS
  Histologic study showed that ovaries from control group exhibited many follicles in various stages of development including primary, secondary and tertiary follicles. There were one or two secondary and tertiary follicles but no primary follicle in each histological section of the 6 months after hysterectomy. The ovaries showed that the cortex of ovary completely covered by corpora lutea, and there were many cystic follicles and atretic follicles with few normal follicles. Theca interna is absent in cysts and most of the mural granulose cell population has been depleted. Serum FSH levels showed significantly increase in hysterectomized group compared control after 6 months operation.
  
  
  CONCLUSIONS
  The results of present study support previous studies and suggest that hysterectomy with ovarian conservation in young patients could preserve a woman's normal hormonal milieu. The uterus could have controlling on ovulation and hysterectomy might accelerate to initiate of early menopause.
authors.affiliation: Department of Histology and Embryology, Erciyes University, Faculty of Medicine, Kayseri, Turkey. ozdamar@erciyes.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Ozdamar
authors.forename: H
authors.initials: H
authors.lastname: Ulger
authors.forename: H Cetin
authors.initials: HC
authors.lastname: Sorkun
authors.forename: I
authors.initials: I
authors.lastname: Müderris
mesh_terms: D000818:Animals; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007044:Hysterectomy; D006080:Ovarian Follicle / Q000473:pathology / Q000502:physiology; D010053:Ovary / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005640:Follicle Stimulating Hormone