The chemical constituents of Ligularia pleurocaulis.
OBJECTIVE
To study the chemical constituents of the underground part of Ligularia pleurocaulis (Franch.) Hand-Mazz.


METHODS
The dried roots and rhizomes of L. pleurocaulis were extracted with methanol. Isolation and purification were performed by silica gel column chromatography and recrystallization etc. Structures of the pure compounds were established on basis of spectral analysis.


RESULTS
Twelve compounds were obtained from L. pleurocaulis, they were 6-angeloyloxy-furanoligularenone (1), 2-oxo-3-hydroxy-eremophila-1(10),3,7(11),8-tetraen-8,12-olide (2), tiglic acid (3), oleanolic acid (4), lupeol (5), beta-sitosterol (6), daucosterol (7), caffeic acid (8), emodin (9), 7-methoxy-coumarin (10), ferulic acid (11) and 4-hydroxy-2,5-dimethoxy-benzaldehyde (12).


CONCLUSIONS
Compound 1 is a new eremophilane and compound 2 is a new natural compound. All above compounds were obtained for the first time from L. pleurocaulis.
Zhang
Mian
M
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China. mianzhang@hotmail.com
Zhang
Chao-Feng
CF
Wang
Zheng-Tao
ZT
D019659:Asteraceae / Q000737:chemistry*; D003437:Crotonates / Q000737:chemistry / Q000302:isolation & purification; D045782:Hemiterpenes; D008968:Molecular Conformation; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
C522385:2-oxo-3-hydroxy-eremophila-1(10),3,7(11),8-tetraen-8,12-olide; C522384:6-angeloyloxy-furanoligularenone; D003437:Crotonates; D045782:Hemiterpenes; D012717:Sesquiterpenes; D009828:Oleanolic Acid; C009489:tiglic acid