Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs.
Interleukin-8 elevation in urine during urinary tract infections (UTIs) has been documented for different uropathogenic germs in 85 patients. We showed that for 17 different isolates, IL-8 was increased in 92% of UTIs with an average value of 627 pg/ml for infected, as compared to 45 pg/ml for uninfected patients. We suggest that the high negative predictive value of the IL-8 urine assay could be useful to eliminate UTIs in routine screenings.
Oregioni
Olivier
O
Laboratoire de Bactériologie, CHU de Nice, France. oregioni.o@chu-nice.fr
Delaunay
Pascal
P
Bruna
Pascal
P
Gaudart
Alice
A
Lemichez
Emmanuel
E
Boquet
Patrice
P
Landraud
Luce
L
D000900:Anti-Bacterial Agents; D001424:Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology / Q000652:urine; D006801:Humans; D016209:Interleukin-8 / Q000652:urine*; D009504:Neutrophils; D011237:Predictive Value of Tests; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000382:microbiology / Q000652:urine
D000900:Anti-Bacterial Agents; D016209:Interleukin-8