D-hormones for prevention of bone loss after organ transplant.
In addition to bisphosphonates, D-hormones appear to be effective agents in the prevention of post-transplant osteoporosis. In this article studies on D-hormone agents for prevention of post-transplant bone loss are reviewed. Potential reduction in immunosuppressive requirements with D-hormone is an additional consideration. Based upon available evidence, prophylaxis should involve a bisphosphonate, with D-hormone considered as adjunctive or alternative therapy.
Sambrook
Philip N
PN
Institute of Bone and Joint Research, University of Sydney, Sydney, Australia. sambrook@med.usyd.edu.au
D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects; D002117:Calcitriol / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D014180:Transplantation / Q000009:adverse effects; D014815:Vitamins / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007166:Immunosuppressive Agents; D014815:Vitamins; D002117:Calcitriol; D002118:Calcium