Glycoprotein Ia 807TT/873AA genotype is not associated with myocardial infarction.
OBJECTIVE
The glycoprotein Ia/IIa complex is a major platelet collagen receptor. Its surface expression is influenced by two linked single nucleotide polymorphisms (C807T and G873A) in the glycoprotein Ia (GPIa) gene. In this study we aimed to determine the frequency of GPIa C807T/G873A genotype in patients with myocardial infarction (MI) and healthy controls in Turkish population and association between these dimorphisms and risk factors of MI.


METHODS
We examined GPIa (C807T/G873A) genotypes in 158 patients with MI and 145 healthy controls. Distributions of the C807T and G873A dimorphisms were investigated by genotyping DNA using multiplexed allele-specific PCR.


RESULTS
There was no association between GPIa genotypes and MI. We further analysed each group for all known risk factors such as plasma lipid levels, cigarette smoking, diabetes, hypertension, gender, age, MI history and body mass index. When compared with other two genotypes for glycoprotein Ia (GT/GA and CC/GG), TT/AA showed an association with higher high-density lipoprotein (HDL) -cholesterol levels in the healthy control group, but none in the group with MI.


CONCLUSIONS
The 807TT/873AA genotype of the GPIa gene alone or in combination with risk factors had no major effect on MI, however, it appears to be associated with higher HDL-cholesterol levels in healthy subjects.
Kömürcü
Evrim
E
Department of Genetics, Institute for Experimental Medical Research, Istanbul Medical School, Istanbul University, Istanbul, Turkey.
Işsever
Halim
H
Erginel-Unaltuna
Nihan
N
D000328:Adult; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D014421:Turkey; D044465:White People / Q000235:genetics
D017931:DNA Primers; D038982:Integrin alpha2beta1