Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant.
We report a case of fatal congenital cytomegalovirus (CMV) disease in a 695 gm, 29 weeks estimated gestational age premature infant. The newborn presented with hydrops fetalis, an unusual presentation of congenital CMV infection. In spite of ganciclovir therapy, the infant succumbed to his illness. Autopsy findings revealed the presence of widespread CMV disease, including pneumonitis, enteritis, and myocarditis. Congenital CMV infection should be considered in the differential diagnosis of hydrops fetalis.
Sampath
Venkatesh
V
Department of Pediatrics, Division of Neonatology, Cincinnati Children's Hospital Medical Center, and Department of Pathology, University of Cincinnati School of Medicine, OH, USA.
Narendran
Vivek
V
Donovan
Edward F
EF
Stanek
Jerzy
J
Schleiss
Mark R
MR
D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital* / Q000175:diagnosis; D017809:Fatal Outcome; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis / Q000208:ethnology*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis; D008297:Male