Effects of an aqueous extract of Puerariae flos (Thomsonide) on impairment of passive avoidance behavior in mice.
The effects of an aqueous extract of Puerariae flos (Thomsonide) on ethanol-induced learning and memory impairment and scopolamine-induced amnesia were investigated. Thomsonide exerted an ameliorating effect on the impairment of both memory registration and memory retrieval induced by ethanol. These results indicate that Thomsonide has an antiamnesic effect on the central nervous system in alcoholic intoxication and support the traditional use of Puerariae flos for the treatment of alcoholic intoxication. Thomsonide also improved the scopolamine-induced impairment of memory registration in passive avoidance behavior in mice. The results of this study suggest that it may be possible to use Thomsonide for the treatment of age-related memory impairment and dementia.
Yamazaki
Takashi
T
Tsukuba Research Institute, Ohat's Isan Co. Ltd., Ushiku, Ibaraki 300-1231, Japan. t_yamazaki@ohta-isan.co.jp
Yaguchi
Masako
M
Nakajima
Yoshijiro
Y
Hosono
Tsuyoshi
T
Niiho
Yujiro
Y
Hibi
Yoshiro
Y
Kinjo
Junei
J
Nohara
Toshihiro
T
D000544:Alzheimer Disease / Q000188:drug therapy / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors / Q000633:toxicity; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D018727:Muscarinic Antagonists / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D029908:Pueraria / Q000737:chemistry*; D012601:Scopolamine / Q000037:antagonists & inhibitors / Q000633:toxicity
D002492:Central Nervous System Depressants; D018727:Muscarinic Antagonists; D010936:Plant Extracts; C505747:Thomsonide; D000431:Ethanol; D012601:Scopolamine