Non-cardiogenic pulmonary oedema induced by salazosulfapyridine.
A 25-year-old woman received oral salazosulfapyridine, 4 g/day, for treatment of ulcerative colitis. At 10 days later, she presented with fever and respiratory symptoms. Based on physical, laboratory and radiological findings, bacterial pneumonia and non-cardiogenic pulmonary oedema was suspected. Salazosulfapyridine was immediately halted and antibiotic therapy started. Two days later, her symptoms and abnormal findings had improved rapidly. Bacteriological studies were negative. Salazosulfapyridine-induced non-cardiogenic pulmonary oedema was diagnosed. Non-cardiogenic pulmonary oedema should be considered as one of several salazosulfapyridine- induced pulmonary diseases in patients who are receiving salazosulfapyridine and who develop respiratory symptoms and an abnormal CXR.
Saito
Takashi
T
Department of Internal Medicine, Federation of Public Services and Affiliated Personnel Aid Associations, Takamatsu Hospital, Kagawa, Japan. saitoh@kkr-ta-hp.gr.jp
Mori
Yoshihiro
Y
Yoshida
Mitsuo
M
Maeta
Tsuyoshi
T
Koui
Fumikazu
F
Harada
Mine
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D011654:Pulmonary Edema / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine