title: Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting.
abstract: There is currently of a great interest investigating the role of nutrition in the prevention of age-associated disorders. The present study aimed to evaluate, on a particular strain of mice, the efficacy of alternate-day fasting on the mitochondrial production of free radical species and on the incidence of a specific cancer (lymphoma) in aged mice. Alternate fasting, that was initiated in middle age mice through a 4 month period, reduced significantly the incidence of lymphoma (0% versus 33% for controls). No remarkable difference was observed in the overall food consumption between alternate-fed (AF) and ad libitum (AL) mice, suggesting that the efficacy of alternate fasting did not really depend on calorie restriction. A significant decrease in the mitochondrial generation of reactive oxygen species (ROS) that was associated with a significant increase in spleen mitochondria SOD activity was observed when mice were maintained on intermittent fasting. Our results suggest that alternate fasting could exert a beneficial antioxidant effect and a modulation of the oxidative stress associated with aging.
authors.affiliation: Laboratoire de Nutrition, Vieillissement, Maladies Cardio-vasculaires, Faculté de Pharmacie, Université de Grenoble, Domaine de la Merci, 38706 la Tronche, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Descamps
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Riondel
authors.forename: Véronique
authors.initials: V
authors.lastname: Ducros
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Roussel
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D004435:Eating; D005215:Fasting; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D017382:Reactive Oxygen Species; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase