title: Centrosome duplication and nematodes: recent insights from an old relationship.
abstract: Centrosome duplication is required for proper cell division, and centriole formation is a key step in this process. This review discusses recent studies in C. elegans that have identified five core proteins required for centriole formation, thus shedding light into the mechanisms underlying centrosome duplication in nematodes and beyond.
authors.affiliation: Swiss Institute for Experimental Cancer Research (ISREC), Lausanne.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Leidel
authors.forename: Pierre
authors.initials: P
authors.lastname: Gönczy
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000378:metabolism / Q000648:ultrastructure; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism; D002502:Centrioles / Q000378:metabolism / Q000648:ultrastructure; D018385:Centrosome / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; C472409:SAS-4 protein, C elegans; C488496:SAS-5 protein, C elegans; C497201:SAS-6 protein, C elegans; C486131:SPD-2 protein, C elegans; D011494:Protein Kinases; C429649:zyg-1 protein, C elegans