title: Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients.
abstract: Narcolepsy is a chronic sleep disorder. It is linked to the HLA-DQB1*0602 allele. A recent report established a genetic linkage between narcolepsy and the chromosomal region 4p13-q21 that contains the Clock gene. We studied two SNPs in the Clock gene aiming to find any association with narcolepsy. We did not find differences in genetic frequencies in the patients group. We concluded that these two SNPs are not associated with narcolepsy.
authors.affiliation: Instituto do Sono/Depto. de Psicobiologia, Rua Napoleão de Barros, 925, 3- andar., São Paulo, SP, Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Moreira
authors.forename: Mario
authors.initials: M
authors.lastname: Pedrazzoli
authors.forename: Fernando Morgadinho
authors.initials: FM
authors.lastname: Dos Santos Coelho
authors.forename: Marcia
authors.initials: M
authors.lastname: Pradella-Hallinan
authors.forename: Maria Cecília
authors.initials: MC
authors.lastname: Lopes da Conceição
authors.forename: Alberto Jorge
authors.initials: AJ
authors.lastname: Pereira Peregrino
authors.forename: Emílio Carlos
authors.initials: EC
authors.lastname: de Oliveira
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
mesh_terms: D001483:Base Sequence; D056926:CLOCK Proteins; D017931:DNA Primers; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D009290:Narcolepsy / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D015534:Trans-Activators / Q000235:genetics*
chemical_list: D017931:DNA Primers; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D008562:Membrane Glycoproteins; D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human