title: Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.
abstract: BACKGROUND
  Plexiform fibrohistiocytic tumor is a soft-tissue tumor of intermediate malignancy occurring in children and young adults but is only rarely found in infants. The tumor usually involves the upper limbs and is slow growing and painless. Recurrence rate is high. Lymph node and systemic metastases can occur, but have never been reported in infants. Clinical behavior in infancy is not known. Histologically, the tumor is characterized by nodules of histiocyte-like and multinucleated cells and fascicles of spindle cells arranged in a plexiform pattern. Mitosis, atypia, and nuclear pleomorphism are common but not pronounced.
  
  
  RESULTS
  We report three cases in infants, one of which is congenital, having an unusual topography and a broad histological spectrum.
  
  
  CONCLUSIONS
  In infants, wide excision with large safety margins should be performed as the behaviour of this tumor remains uncertain. Leclerc S, Hamel-Teillac D, Oger P, Brousse N, Fraitag S. Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy.
authors.affiliation: Department of Pathology, Necker-Enfants Malades Hospital, Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Leclerc
authors.forename: Dominique
authors.initials: D
authors.lastname: Hamel-Teillac
authors.forename: Patrice
authors.initials: P
authors.lastname: Oger
authors.forename: Nicole
authors.initials: N
authors.lastname: Brousse
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fraitag
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor