title: Prediction of pK(a) for neutral and basic drugs based on radial basis function Neural networks and the heuristic method.
abstract: OBJECTIVE
  Quantitative structure-property relationships (QSPR) were developed to predict the pK(a) values of a set of neutral and basic drugs via linear and nonlinear methods. The ability of the models to predict pK(a) was assessed and compared.
  
  
  METHODS
  The descriptors of 74 neutral and basic drugs in this study were calculated by the software CODESSA, which can calculate constitutional, topological, geometrical, electrostatic, and quantum chemical descriptors. Linear and nonlinear QSPR models were developed based on the heuristic method (HM) and radial basis function neural networks (RBFNN), respectively. The heuristic method was also used for the preselection of appropriate molecular descriptors.
  
  
  RESULTS
  The obtained linear model had a correlation coefficient of r=0.884, F=37.72 with a root-mean-squared (RMS) error of 0.482 for the training set, and r=0.693, F=11.99, nd RMS=0.987 for the test set. The RMS in predicting the overall data set is 0.619. The nonlinear model gave better results; for the training set, r=0.886, F=202.314, and RMS=0.458, and for the test set r=0.737, F=15.41, and RMS=0.613. The RMS error in prediction for overall data set is 0.493. Prediction results from nonlinear model are in good agreement with experimental values.
  
  
  CONCLUSIONS
  In present study, we developed a QSPR model to predict the important parameter (pK(a)) of neutral and basic drugs. The model is useful in predicting pK(a) during the discovery of new drugs when experimental data are unknown.
authors.affiliation: Department of Chemistry, Lanzhou University, Lanzhou 730000, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Luan
authors.forename: Weiping
authors.initials: W
authors.lastname: Ma
authors.forename: Haixia
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zhang
authors.forename: Mancang
authors.initials: M
authors.lastname: Liu
authors.forename: Zhide
authors.initials: Z
authors.lastname: Hu
authors.forename: Botao
authors.initials: B
authors.lastname: Fan
mesh_terms: D016571:Neural Networks, Computer; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D004364:Pharmaceutical Preparations