Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism.
One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol dependence (familial) and alcoholic patients without family history (non-familial). Genotype and allele frequencies of ALDH2 G1951A SNP in familial or non-familial alcoholic patients differ from normal controls. Neither 5-HTTLPR L/S nor DAT1 G2319A SNP genotypes nor alleles discriminated alcoholic patients from normal controls. These findings suggest that the genetic characteristics of alcohol metabolism in non-familial alcoholics fall between non-alcoholism and familial alcoholics.
Choi
Ihn-Geun
IG
Department of Neuropsychiatry, Hallym University Han-Gang Sacred Heart Hospital, Seoul, Republic of Korea.
Kee
Baik Seok
BS
Son
Hyun-Gyun
HG
Ham
Byung Joo
BJ
Yang
Byung-Hwan
BH
Kim
Seok Hyeon
SH
Lee
Jun-Suk
JS
Son
Bong Ki
BK
Lee
Byeong-Yong
BY
Lee
Sang-Yeol
SY
Chai
Young-Gyu
YG
Shin
Hyoung Doo
HD
D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D004247:DNA / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005190:Family; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D007723:Korea / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050483:Dopamine Plasma Membrane Transport Proteins; D007527:Isoenzymes; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase