Plasma orexin A, orexin B, leptin, neuropeptide Y (NPY) and insulin in obese women.
OBJECTIVE
It has been reported that the peptides such as orexins, neuropeptide Y (NPY) and leptin may play an important role in the regulation of appetite and energy metabolism. The interaction between leptin, orexins and NPY, as well as between peptides and insulin and cortisol in the different nutritional states have been investigated in animals. However, at present this relationship is poorly understood in humans.


METHODS
Material consisted of 36 obese women and 16 lean women. Plasma orexin A, orexin B, neuropeptide Y (NPY), leptin, insulin concentrations were measured with RIA methods.


RESULTS
Plasma orexin A concentrations were significantly lower in obese women as compared with control group. Plasma orexin A was significantly lower in severe obesity (BMI > 40 kg/m2) than that in moderate obesity (BMI < 40 kg/m2). Plasma orexin B concentrations did not change. However, plasma NPY, leptin and insulin levels were markedly higher in obese women, especially in severe obesity.


CONCLUSIONS
Our results confirmed the thesis that orexin A, NPY, leptin play an important role in the regulation of energy metabolism in humans. In obesity the activity of these peptides is disturbed.
Baranowska
Boguslawa
B
Department of Neuroendocrinology Medical Centre of Postgraduate Education, Warsaw, Poland. zncmkp@op.pl
Wolińska-Witort
Ewa
E
Martyńska
L
L
Martyńska
M
M
Chmielowska
Magdalena
M
Baranowska-Bik
Agnieszka
A
D000328:Adult; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009478:Neuropeptide Y / Q000097:blood*; D009479:Neuropeptides / Q000097:blood*; D009765:Obesity / Q000097:blood*; D000068797:Orexins; D011863:Radioimmunoassay
C000596229:HCRT protein, human; D007328:Insulin; D047908:Intracellular Signaling Peptides and Proteins; D020738:Leptin; D009478:Neuropeptide Y; D009479:Neuropeptides; D000068797:Orexins