title: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging.
abstract: Alitretinoin (9-cis-retinoic acid) is an FDA-approved topical therapy for the treatment of Kaposi sarcoma. Alitretinoin is a naturally occurring endogenous retinoid that binds to and activates all known intracellular retinoic acid receptor (RAR) subtypes alpha, beta, and gamma and retinoic X receptor (RXR) subtypes alpha, beta, and gamma. Photoaging of the skin is the result of accumulated exposure to solar UV radiation. Several topically applied retinoids have been proven clinically effective for treating the appearance of photoaging. Tretinoin and tazarotene, which have been shown to improve photodamaged skin, bind RAR subtypes only. The theoretic benefit of alitretinoin gel 0.1% (Panretin) in the treatment of photoaged skin stems from the binding and activation of both RARs and RXRs, which promote the repair mechanisms in damaged skin. The objective of this study was to evaluate the safety and efficacy of topical alitretinoin gel 0.1% in the treatment of photodamaged skin. The treatment was well tolerated by participants (N=20) and subjectively showed improvement of benign skin lesions (eg, seborrheic keratoses) and precancerous lesions (eg, actinic keratoses). Larger, blinded, controlled trials are needed to investigate the role of this novel retinoid in the treatment of photoaging.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida, USA. lsb@derm.net
authors.forename: Leslie
authors.initials: L
authors.lastname: Baumann
authors.forename: Justin
authors.initials: J
authors.lastname: Vujevich
authors.forename: Monica
authors.initials: M
authors.lastname: Halem
authors.forename: Lucy K
authors.initials: LK
authors.lastname: Martin
authors.forename: Francisco
authors.initials: F
authors.lastname: Kerdel
authors.forename: Melissa
authors.initials: M
authors.lastname: Lazarus
authors.forename: Heather
authors.initials: H
authors.lastname: Pacheco
authors.forename: Laura
authors.initials: L
authors.lastname: Black
authors.forename: Joy
authors.initials: J
authors.lastname: Bryde
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000077556:Alitretinoin; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D005782:Gels; D000077556:Alitretinoin; D014212:Tretinoin