A method to quantify at late imaging a release rate of 18F-FDG in tissues.
This theoretical work shows that the rate constant for the (18)F-FDG release in tissues can be assessed without needing any arterial blood sampling. The method requires that the clearance of (18)F-FDG from plasma has occurred, whereas (18)F-FDG is still present in the tissue. This condition can be met dating from 3 h after (18)F-FDG injection, when hydration and/or phlorizin injection are applied after the routine static acquisition. The release rate constant can be obtained from a graphical analysis performed at the later decreasing phase of the tissue tracer activity. A two-compartment and a three-compartment model are developed, both in accordance with one another. To cite this article: E. Laffon et al., C. R. Biologies 328 (2005).
Laffon
Eric
E
Service de médecine nucléaire, hôpital du Haut-Lévêque, centre hospitalo-universitaire de Bordeaux, av. de Magellan, 33600 Pessac, France. elaffon@u-bordeaux2.fr
Allard
Michèle
M
Marthan
Roger
R
Ducassou
Dominique
D
D019788:Fluorodeoxyglucose F18 / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D019275:Radiopharmaceuticals / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics; D014018:Tissue Distribution
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18