Determination of promethazine hydrochloride and its preparations by highly accurate nephelometric titration.
A highly accurate nephelometric titration for the determination of promethazine hydrochloride and its preparations was presented. The titration operating conditions were studied and the solubility product constant of promethazine tetraphenylboron precipitation was determined. The result of the titration is comparable to those of control experiments. The proposed method has been found to be accurate, precise, specific and linear.
Zhang
Qi
Q
West China School of Pharmacy, Sichuan University, No. 17, Section 3, Ren-Min-Nan-Lu Rd., Chengdu, Sichuan 610041, PR China.
Zhan
Xiancheng
X
Li
Chengrong
C
Lin
Tao
T
Li
Linli
L
Yin
Xiaodong
X
He
Ning
N
Shi
Yan
Y
D009391:Nephelometry and Turbidimetry / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011398:Promethazine / Q000032:analysis*; D015203:Reproducibility of Results; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods; D017186:Titrimetry / Q000379:methods* / Q000639:trends
D004364:Pharmaceutical Preparations; D013607:Tablets; D011398:Promethazine