title: Lack of association of p53 polymorphisms and haplotypes in high and normal tension open angle glaucoma.
abstract: BACKGROUND
  The final common pathway for open angle glaucoma (OAG) is retinal ganglion cell apoptosis. Polymorphisms in p53, a major regulator of apoptosis, affect the efficiency of cell death induction. Association studies of p53 haplotypes and OAG have had conflicting results.
  
  
  OBJECTIVE
  To examine the association between p53 haplotypes and OAG in a larger white population than in previous reports, and extend the analysis to normal tension glaucoma.
  
  
  METHODS
  345 unrelated people with OAG were recruited (283 subjects with high tension glaucoma and 62 with normal tension glaucoma) and compared with 178 age matched controls. Genomic DNA was analysed for the p53 codon 72 Arg/Pro polymorphism as well as for the presence or absence of a 16 bp intron 3 insertion.
  
  
  RESULTS
  In this white cohort no association was found between glaucoma (high or normal tension) and either sequence variant or haplotype.
  
  
  CONCLUSIONS
  The p53 codon 72 Arg/Pro polymorphism is not associated with age of onset or severity of glaucoma.
authors.forename: D P
authors.initials: DP
authors.lastname: Dimasi
authors.forename: A W
authors.initials: AW
authors.lastname: Hewitt
authors.forename: C M
authors.initials: CM
authors.lastname: Green
authors.forename: D A
authors.initials: DA
authors.lastname: Mackey
authors.forename: J E
authors.initials: JE
authors.lastname: Craig
mesh_terms: D000483:Alleles; D003062:Codon; D015331:Cohort Studies; D005260:Female; D014644:Genetic Variation; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53