Isolation of lignans and biological activity studies of Ephedra viridis.
Phytochemical investigation of Ephedra viridis (whole plant) led to the isolation of four lignans including (+)-9-acetoxyisolariciresinol, which is a new lignan, lariciresinol, 9-acetoxylariciresinol and isolariciresinol. All the isolates were tested for their antioxidant activity and cytotoxicity against a panel of solid tumor and human leukemia cells. They were also screened for estrogenic activity using a recombinant yeast estrogen screening (YES) assay. Most of the lignans exhibited moderate antioxidant activity without any cytotoxicity. None of them were estrogenic in the YES assay.
Pullela
Srinivas V
SV
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, 38677, USA.
Takamatsu
Satoshi
S
Khan
Shabana I
SI
Khan
Ikhlas A
IA
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D029789:Ephedra; D004967:Estrogens / Q000096:biosynthesis; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D004967:Estrogens; D017705:Lignans; D010936:Plant Extracts