title: 1,3-dipolar cycloaddition on solid supports: nitrone approach towards isoxazolidines and isoxazolines and subsequent transformations.
abstract: 1,3-dipolar cycloaddition reactions of nitrones with alkenes and alkynes are well-studied reactions in solution-phase organic chemistry. However, the number of studies concerned with their application in solid-phase organic synthesis is rather low compared to other 1,3-dipoles, e.g. azides or nitrile oxides. This tutorial review aims to summarise the main approaches towards the application of nitrones in 1,3-dipolar cycloaddition reactions on solid supports in addition to subsequent transformations with polymer-bound isoxazolidines and reactions using polymer-bound catalysts.
authors.affiliation: Technische Universität Berlin, Institut für Chemie, D-10623 Berlin, Germany.
authors.forename: Karola
authors.initials: K
authors.lastname: Rück-Braun
authors.forename: Tonia H E
authors.initials: TH
authors.lastname: Freysoldt
authors.forename: Frank
authors.initials: F
authors.lastname: Wierschem