title: In vitro activity and killing effect of uperin 3.6 against gram-positive cocci isolated from immunocompromised patients.
abstract: The in vitro activity of uperin 3.6, alone or combined with six antibiotics, against gram-positive cocci, including Rhodococcus equi, methicillin-resistant staphylococci, and vancomycin-resistant enterococci, was investigated. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline.
authors.affiliation: Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Giacometti
authors.forename: Oscar
authors.initials: O
authors.lastname: Cirioni
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kamysz
authors.forename: Carmela
authors.initials: C
authors.lastname: Silvestri
authors.forename: Alberto
authors.initials: A
authors.lastname: Licci
authors.forename: Giuseppina
authors.initials: G
authors.lastname: D'Amato
authors.forename: Piotr
authors.initials: P
authors.lastname: Nadolski
authors.forename: Alessandra
authors.initials: A
authors.lastname: Riva
authors.forename: Jerzy
authors.initials: J
authors.lastname: Lukasiak
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D029845:Amphibian Proteins / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004357:Drug Synergism; D016983:Enterococcus / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects*; D016867:Immunocompromised Host; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology*; D016929:Rhodococcus equi / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D020713:Vancomycin Resistance
chemical_list: D029845:Amphibian Proteins; D000900:Anti-Bacterial Agents; D010455:Peptides; C121472:uperin 3.6 peptide, Uperoleia mjobergii; D017291:Clarithromycin; D004318:Doxycycline