Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.
Structures are proposed, based on LC-ion trap MSn analysis and high-resolution FTICR MS/MS analysis, for a novel family of mycolactone toxins isolated from the frog pathogen MU128FXT and differing from those produced by the human pathogen M. ulcerans MUAgy99 in having an altered polyketide side chain.
Hong
Hui
H
Departments of Chemistry and Biochemistry, University of Cambridge, Cambridge, UK.
Stinear
Tim
T
Skelton
Paul
P
Spencer
Jonathan B
JB
Leadlay
Peter F
PF
D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry*; D002853:Chromatography, Liquid; D003903:Deuterium / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry*; D013058:Mass Spectrometry; D009161:Mycobacterium / Q000737:chemistry*; D009164:Mycobacterium Infections / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014981:Xenopus / Q000382:microbiology*
D001427:Bacterial Toxins; D007783:Lactones; D003903:Deuterium