title: Glucose-6-phosphate dehydrogenase (G6PD) mutations in Cambodia: G6PD Viangchan (871G>A) is the most common variant in the Cambodian population.
abstract: We conducted a survey of malaria diagnoses and glucose-6-phosphate dehydrogenase (G6PD) testing in remote areas of Cambodia. Blood specimens from 670 people were collected by the finger-prick method. Of these people, 24.9% were found to have malaria, and 7.0% of people were G6PD deficient. In the Khmer, the largest ethnical population in Cambodia, the G6PD deficiency rate of males was 12.6% (25/199) whereas the rates in the minorities of the Tum Pun and the Cha Ray were 1.1% (1/93) and 3.2% (2/63), respectively. Of the G6PD-deficient subjects, 97.9% (46/47) were G6PD Viangchan (871G>A), and only one case (2.1%) was G6PD Union (1360C>T). Since G6PD Mahidol (487G>A) is common in Myanmar according to our previous study, the current finding suggests that the Cambodian population is derived from homogeneous ancestries and is different from the Myanmar population. All G6PD Viangchan cases were linked to two other mutations of 1311C>T and IVS-11 nt93T>C in the G6PD gene.
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushij, Minami-kawachi, Tochigi, 329-0498, Japan. hiroyuki@jichi.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsuoka
authors.affiliation: National Malaria Center, Ministry of Health, Phnom Penh, Cambodia.
authors.forename: Chea
authors.initials: C
authors.lastname: Nguon
authors.affiliation: Department of Advanced Medical Science, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kanbe
authors.affiliation: Department of Advanced Medical Science, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Amadu
authors.initials: A
authors.lastname: Jalloh
authors.affiliation: Faculty of Medicine, Department of Infectious Disease Control, Oita University, Oita, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sato
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushij, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yoshida
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushij, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirai
authors.affiliation: Department of Medical Zoology, Jichi Medical School, 3311-1 Yakushij, Minami-kawachi, Tochigi, 329-0498, Japan.
authors.forename: Meiji
authors.initials: M
authors.lastname: Arai
authors.affiliation: National Malaria Center, Ministry of Health, Phnom Penh, Cambodia.
authors.forename: Duong
authors.initials: D
authors.lastname: Socheat
authors.affiliation: Faculty of Medicine, Institute of Scientific Research, Oita University, Oita, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kawamoto
mesh_terms: D002160:Cambodia / Q000453:epidemiology; D004252:DNA Mutational Analysis; D017931:DNA Primers; D005006:Ethnicity / Q000235:genetics*; D005820:Genetic Testing; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology; D008297:Male; D009154:Mutation / Q000235:genetics*; D015995:Prevalence; D011319:Primaquine / Q000009:adverse effects / Q000627:therapeutic use; D017422:Sequence Analysis, DNA
chemical_list: D017931:DNA Primers; D005954:Glucosephosphate Dehydrogenase; D011319:Primaquine