Bloodless (transfusion-free) hematopoietic stem cell transplants: the Mexican experience.
We have analyzed the transfusion requirements of a group of 132 peripheral blood stem cell transplants from a single institution (73 allografts and 59 autografts) over a 10-year period. The allografts were conducted using the 'Mexican' nonmyeloablative conditioning regimen, while the autografts were given single-day high-dose melphalan. For the allografts, the median number of transfused packed red blood (PRBC) cell units was 1 (range 0-22), while the median number of platelet transfusion (PLT) sessions was 1 (range 0-9); 45% of allografted individuals did not require PRBC transfusions and 35% did not require PLT. For autografts, the median number of PRBC units was 2 (range 0-21), while the median number of PLT was 2 (range 0-21); 33% of autografted individuals did not require PRBC and 25% did not require PLT. We conclude that, by using certain preparative regimens, both allo and auto hematopoietic stem cell grafts can be conducted without the transfusion of blood products.
Ruiz-Argüelles
G J
GJ
Centro de Hematología y Medicina Interna de Puebla, Puebla, PUE, México. gruiz1@clinicaruiz.com
Morales-Toquero
A
A
López-Martínez
B
B
Tarín-Arzaga
L-del-C
LD
Manzano
C
C
D000293:Adolescent; D000328:Adult; D001781:Blood Component Removal / Q000379:methods; D002648:Child; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous