title: Associations of Fas (CD95), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), and biochemical manifestations in elderly persons.
abstract: BACKGROUND
  This study investigated the relationships of soluble Fas (CD95) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) vs. biochemical manifestations.
  
  
  METHODS
  Serum concentrations of soluble Fas, TRAIL, and biochemical parameters were measured in 171 healthy adults.
  
  
  RESULTS
  There were no significant age- and gender-related differences in Fas and TRAIL concentrations. However, aspartate and alanine aminotransferase and gamma-glutamyl transferase (AST, ALT, and GGT) activities were significantly higher in men with Fas > or =429.5 and TRAIL > or =63.2 pg/ml than in those with Fas <429.5 and TRAIL <63.2 pg/ml (26.8+/-10.9, 33.2+/-14.6, and 79.2+/-46.9 IU/l vs. 17.6+/-4.6, 20.4+/-7.8, and 35.3+/-21.3 IU/l, p<0.05, respectively). Serum triglyceride, total protein, and uric acid concentrations averaged 172.8+/-58.4 mg/dl, 7.8+/-0.3 g/dl, and 4.8+/-1.1 mg/dl in women with Fas > or =352.1 and TRAIL > or =64.9 pg/ml, which were significantly above the values of those with Fas <352.1 and TRAIL <64.9 pg/ml (116.9+/-49.2 mg/dl, 7.4+/-0.3 g/dl, and 3.7+/-0.7 mg/dl, p<0.05, respectively). Serum soluble Fas concentrations correlated significantly with AST (r=0.36, p<0.05), ALT (r=0.30, p<0.05), and GGT (r=0.29, p<0.05) in men and triglyceride (r=0.34, p<0.05), protein (r=0.27, p<0.05), and uric acid levels (r=0.41, p<0.05) in women.
  
  
  CONCLUSIONS
  Apoptotic activity seems to have an important relationship to biochemical parameters, especially hepatic enzymes, total protein, triglyceride, and uric acid in elderly persons.
authors.affiliation: Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Incheon 400-711, South Korea.
authors.forename: Jong Weon
authors.initials: JW
authors.lastname: Choi
mesh_terms: D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001774:Blood Chemical Analysis; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D011485:Protein Binding; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor