Regeneration and tolerance factor. A vacuolar ATPase with consequences.
Embryonic-maternal signaling is vital to implantation. We have identified a cellular protein that indirectly regulates secretion of IL-1beta, a proinflammatory cytokine that is involved in this signaling process. Regeneration and tolerance factor is a V-ATPase protein that regulates ATP levels in a variety of cells including macrophages, which, in turn, regulates the P2X7 ligand-gated ion channel. As extracellular levels of ATP rise, the P2X7 receptor undergoes a change in permeability, which leads to the onset of apoptotic events and the release of IL-1beta. IL-1beta leads to local inflammation and vascularization, which is integral to establishing a successful implantation site.
Levine
Rita F
RF
Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, Ill., USA.
Derks
Richards
R
Beaman
Kenneth
K
D000818:Animals; D017209:Apoptosis; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics / Q000378:metabolism; D008213:Lymphocyte Activation; D008431:Maternal-Fetal Exchange / Q000276:immunology / Q000502:physiology; D051379:Mice; D011247:Pregnancy; D018048:Receptors, Purinergic P2 / Q000276:immunology / Q000378:metabolism; D058486:Receptors, Purinergic P2X7; D013491:Suppressor Factors, Immunologic / Q000235:genetics / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D025262:Vacuolar Proton-Translocating ATPases / Q000276:immunology* / Q000378:metabolism; D006180:Proton-Translocating ATPases
D007375:Interleukin-1; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D013491:Suppressor Factors, Immunologic; D025262:Vacuolar Proton-Translocating ATPases; C546468:P2RX7 protein, human; C546469:P2rx7 protein, mouse; C475700:regeneration and tolerance factor; C525845:ATP6V0A2 protein, human; D006180:Proton-Translocating ATPases