An analytical solution for percutaneous drug absorption: application and removal of the vehicle.
The methods of Laplace transform were used to solve a mathematical model developed for percutaneous drug absorption. This model includes application and removal of the vehicle from the skin. A system of two linear partial differential equations was solved for the application period. The concentration of the medicinal agent in the skin at the end of the application period was used as the initial condition to determine the distribution of the drug in the skin following instantaneous removal of the vehicle. The influences of the diffusion and partition coefficients, clearance factor and vehicle layer thickness on the amount of drug in the vehicle and the skin were discussed.
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Otto H. York Chemical Engineering Department, New Jersey Institute of Technology, University Heights, Newark, NJ 07102, USA. laurent.simon@njit.edu
Loney
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D000279:Administration, Cutaneous; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D010599:Pharmacokinetics; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption / Q000502:physiology*; D013999:Timolol / Q000008:administration & dosage / Q000493:pharmacokinetics
D000319:Adrenergic beta-Antagonists; D013999:Timolol