Intermittent catheterisation with hydrophilic-coated catheters (SpeediCath) reduces the risk of clinical urinary tract infection in spinal cord injured patients: a prospective randomised parallel comparative trial.
OBJECTIVE
To compare the performance of SpeediCath hydrophilic-coated catheters versus uncoated polyvinyl chloride (PVC) catheters, in traumatic spinal cord injured patients presenting with functional neurogenic bladder-sphincter disorders.


METHODS
A 1-year, prospective, open, parallel, comparative, randomised, multi centre study included 123 male patients, > or =16 y and injured within the last 6 months. Primary endpoints were occurrence of symptomatic urinary tract infection (UTI) and hematuria. Secondary endpoints were development of urethral strictures and convenience of use. The main hypothesis was that coated catheters cause fewer complications in terms of symptomatic UTIs and hematuria.


RESULTS
57 out of 123 patients completed the 12-month study. Fewer patients using the SpeediCath hydrophilic-coated catheter (64%) experienced 1 or more UTIs compared to the uncoated PVC catheter group (82%) (p = 0.02). Thus, twice as many patients in the SpeediCath group were free of UTI. There was no significant difference in the number of patients experiencing bleeding episodes (38/55 SpeediCath; 32/59 PVC) and no overall difference in the occurrence of hematuria, leukocyturia and bacteriuria.


CONCLUSIONS
The results indicate that there is a beneficial effect regarding UTI when using hydrophilic-coated catheters.
De Ridder
D J M K
DJ
Department of Urology, University Hospitals KU Leuven, Belgium. Dirk.deridder@uz.kuleuven.ac.be
Everaert
K
K
Fernández
L García
LG
Valero
J V Forner
JV
Durán
A Borau
AB
Abrisqueta
M L Jauregui
ML
Ventura
M G
MG
Sotillo
A Rodriguez
AR
D000293:Adolescent; D000328:Adult; D002404:Catheterization; D016009:Chi-Square Distribution; D020099:Coated Materials, Biocompatible; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D010577:Petrolatum / Q000494:pharmacology*; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D016037:Single-Blind Method; D013119:Spinal Cord Injuries / Q000150:complications* / Q000175:diagnosis; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000209:etiology / Q000628:therapy*; D014546:Urinary Catheterization / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000517:prevention & control*
D020099:Coated Materials, Biocompatible; D010577:Petrolatum