title: Switch-peptides: controlling self-assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migrations.
abstract: The sequential triggering (Soff --> Son) of O, N-acyl migrations (AcM) by chemical and enzymatic methods (Ti) in peptides containing structure-disrupting switch-elements, S (switch-peptides), offers a novel tool for studying in statu nascendi the onset and inhibition of polypeptide folding and self-assembly as a key process in degenerative diseases.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering, CH-1015 Lausanne, Switzerland.
authors.forename: Sonia
authors.initials: S
authors.lastname: Dos Santos
authors.forename: Arunan
authors.initials: A
authors.lastname: Chandravarkar
authors.forename: Bhubaneswar
authors.initials: B
authors.lastname: Mandal
authors.forename: Richard
authors.initials: R
authors.lastname: Mimna
authors.forename: Karine
authors.initials: K
authors.lastname: Murat
authors.forename: Lydiane
authors.initials: L
authors.lastname: Saucède
authors.forename: Patricia
authors.initials: P
authors.lastname: Tella
authors.forename: Gabriele
authors.initials: G
authors.lastname: Tuchscherer
authors.forename: Manfred
authors.initials: M
authors.lastname: Mutter
mesh_terms: D000215:Acylation; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D007700:Kinetics; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D016229:Amyloid beta-Peptides; D010455:Peptides