Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals.
We analyzed all the exons and exon-intron junctions of the CYP2D6 gene from 286 Japanese individuals. We detected two novel single nucleotide polymorphisms (SNPs) 2556C>T in exon 5 (Thr261Ile) and 3835A>C in exon 8 (Lys404Gln). Both these SNPs showed a frequency of 0.002.
Ebisawa
Aiko
A
Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University, Sendai, Japan.
Hiratsuka
Masahiro
M
Sakuyama
Kanako
K
Konno
Yumiko
Y
Sasaki
Takamitsu
T
Mizugaki
Michinao
M
D044466:Asian People; D019389:Cytochrome P-450 CYP2D6 / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D004247:DNA; D019389:Cytochrome P-450 CYP2D6