title: Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
abstract: A series of serotonin 5-HT1B ligands were synthesized and evaluated for their potency and selectivity against other 5-HT receptor subtypes. Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor and compound 6c was found to have the in vitro binding profile necessary for development as a PET radioligand.
authors.affiliation: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. hh285@columbia.edu
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Huang
authors.forename: Sung-A
authors.initials: SA
authors.lastname: Bae
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Marc
authors.initials: M
authors.lastname: Laruelle
mesh_terms: D000577:Amides; D006801:Humans; D008024:Ligands; D010879:Piperazines; D011485:Protein Binding; D011869:Radioligand Assay; D044302:Receptor, Serotonin, 5-HT1B / Q000737:chemistry / Q000378:metabolism*; D018490:Serotonin Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D008024:Ligands; D010879:Piperazines; D044302:Receptor, Serotonin, 5-HT1B; D018490:Serotonin Agents; C031503:phenylpiperazine