title: Lateral skull base malignancies.
abstract: OBJECTIVE
  Historically poor outcomes have been characteristic in patients with lateral skull base malignancies. As advances in skull base surgical techniques have been made, complete resection has increasingly been achieved. This has resulted in improved survival rates and local tumor control.
  
  
  METHODS
  The authors performed a retrospective review of 95 patients treated for lateral skull base malignancies. The mean age of the patients was 49.4 years. There were 44 females and 51 males. The mean follow-up period was 50 months. Resection was performed in all patients, and postoperative radiotherapy was undertaken in 54% of the cases. Local disease control was maintained in 73% of the patients. Tumor involvement of the facial nerve and intracranial tumor extension did not jeopardize the rate of local control.
  
  
  CONCLUSIONS
  Despite the fact that technical advances in skull base surgery have resulted in a higher incidence of complete tumor resection and improved survival rates, a respect for the poor prognosis historically associated with lateral skull base malignancies should be maintained and treatment should be appropriately aggressive.
authors.affiliation: Hawaiian Island Ear, Nose, and Throat Specialists, Honolulu, Hawaii, USA.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: McGrew
authors.forename: C Gary
authors.initials: CG
authors.lastname: Jackson
authors.forename: Raquel A
authors.initials: RA
authors.lastname: Redtfeldt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019771:Axotomy; D002343:Carotid Artery, Internal / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003391:Cranial Nerves / Q000601:surgery; D005154:Facial Nerve / Q000473:pathology / Q000601:surgery; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D011183:Postoperative Complications / Q000209:etiology; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D016019:Survival Analysis; D013701:Temporal Bone / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome