title: First observation of an Hashimoto thyroiditis-like disease in horses from Eastern Europe: histopathological and immunological findings.
abstract: Among 622 slaughtered horses from eastern Europe, 156 thyroid glands were selected on the basis of macroscopic alterations (e.g., determination of volume and weight). In the 80% of these thyroids, microscopic alterations consistent with a diagnosis of Hashimoto thyroiditis-like disease were found. In particular, a subverted architecture of the thyroid gland with colloid rarefaction, lymphocytic infiltration, and fibrosis was noted. The confirmation of the histopathological diagnosis of an equine Hashimoto thyroiditis-like disease was provided by the increased serum concentration of thyroglobulin, of antithyroglobulin, and of antithyroid peroxidase autoantibodies. Despite evidence consistent with an Hashimoto thyroiditis-like disease in eastern European horses, the etiopathogenesis of this autoimmune disorder deserves further investigation. In this respect, in some horses histopathological alterations in the pituitary gland may suggest an as-yet-unidentified disorder within the hypothalamus-pituitary adrenal axis associated with Hashimoto thyroiditis.
authors.affiliation: Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Perillo
authors.forename: G
authors.initials: G
authors.lastname: Passantino
authors.forename: L
authors.initials: L
authors.lastname: Passantino
authors.forename: A
authors.initials: A
authors.lastname: Cianciotta
authors.forename: A M
authors.initials: AM
authors.lastname: Mastrosimini
authors.forename: P
authors.initials: P
authors.lastname: Lacovazzi
authors.forename: P
authors.initials: P
authors.lastname: Venezia
authors.forename: E
authors.initials: E
authors.lastname: Jirillo
authors.forename: A
authors.initials: A
authors.lastname: Troncone
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D005061:Europe, Eastern / Q000453:epidemiology; D050031:Hashimoto Disease / Q000473:pathology / Q000662:veterinary*; D006734:Horse Diseases / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D006736:Horses; D007453:Iodide Peroxidase / Q000097:blood / Q000276:immunology; D009929:Organ Size; D010902:Pituitary Gland / Q000473:pathology; D013954:Thyroglobulin / Q000097:blood / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013954:Thyroglobulin; D007453:Iodide Peroxidase