title: Aging of human skeletal muscles.
abstract: Normal aging in humans is associated with progressive decrease in skeletal muscle mass and strength (sarcopenia) which contributes to frailty and falls. The age associated changes in body composition result from lower levels of anabolic hormones, oxidative damage, neuromuscular alterations and a general decrease in muscle protein turnover. In this review we discuss the potential mechanisms and physical activity as prevention and treatment of sarcopenia.
authors.affiliation: Department of Anatomy, Medical Faculty, University of Rijeka, Rijeka, Croatia. marina.nikolic@medri.hr
authors.forename: Marina
authors.initials: M
authors.lastname: Nikolić
authors.forename: Snjezana
authors.initials: S
authors.lastname: Bajek
authors.forename: Dragica
authors.initials: D
authors.lastname: Bobinac
authors.forename: Tamara Soić
authors.initials: TS
authors.lastname: Vranić
authors.forename: Romana
authors.initials: R
authors.lastname: Jerković
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D016330:Frail Elderly; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009046:Motor Neurons; D018908:Muscle Weakness; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism*; D009133:Muscular Atrophy; D018384:Oxidative Stress; D014176:Protein Biosynthesis
chemical_list: D016207:Cytokines; D006133:Growth Substances