title: Functional films of maleic anhydride copolymers under physiological conditions.
abstract: Reactivity and swelling of nanometer films of alternating maleic anhydride copolymers were investigated in dependence on the kind of comonomer and molar mass of copolymer in aqueous solution at pH 7.4 and pH 3.0 in order to reveal their characteristics under physiological conditions. Fully hydrolyzed (maleic acid) chains of the copolymers with styrene, propene, and ethylene comonomers covalently bound to SiO2 substrates showed a "mushroom" swelling behavior at pH 7.4 with a layer thickness scaling of N3/5. Decreasing the environmental pH was found to induce a comonomer-dependent shrinking or collapse of the immobilized polymers due to the change in ionization. From the swelling kinetics of non-hydrolyzed chains, the time constants and characteristics of swelling and anhydride hydrolysis were determined and found to depend on the type of comonomer. The short- and long-term swelling kinetics [l approximately t and approximately ln(t)1/2] were found to be in agreement with theoretical models of polymer swelling, while at intermediate time scales enhanced swelling was observed due to hydrolysis reaction of maleic anhydride groups. The findings elucidate the variety of properties of maleic anhydride copolymer films under physiological conditions, which can advantageously be applied for biofunctionalization of different templates.
authors.affiliation: Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Str. 6, 01069 Dresden, Germany. pompe-tilo@ipfdd.de
authors.forename: Tilo
authors.initials: T
authors.lastname: Pompe
authors.forename: Lars
authors.initials: L
authors.lastname: Renner
authors.forename: Milauscha
authors.initials: M
authors.lastname: Grimmer
authors.forename: Nicole
authors.initials: N
authors.lastname: Herold
authors.forename: Carsten
authors.initials: C
authors.lastname: Werner
mesh_terms: D000475:Alkenes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008298:Maleates / Q000737:chemistry; D008299:Maleic Anhydrides / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D011095:Polyethylenes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011126:Polypropylenes / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D000475:Alkenes; D008298:Maleates; D008299:Maleic Anhydrides; D011095:Polyethylenes; D011108:Polymers; D011126:Polypropylenes; D011137:Polystyrenes; D014867:Water; D012822:Silicon Dioxide; C007668:ethylene-maleic anhydride copolymer; C025704:Styromal; C109760:1-octadecene