title: Relation of C-reactive protein and one-year survival after acute myocardial infarction with versus without statin therapy.
abstract: We evaluated the interaction between inflammation and survival benefit from statin therapy in patients who had acute myocardial infarction. Although 1-year mortality did not differ between patients who used statin therapy and those who did not, among patients who had C-reactive protein (CRP) concentrations in the lower 2 tertiles (<2.9 mg/L), 1-year mortality was higher in patients who used statin therapy than in those who did not within the highest CRP-defined tertile (> or =2.9 mg/L). Statin therapy significantly decreased the hazard ratio for 1-year mortality in patients who had high CRP levels to approximately the hazard present for patients who had low CRP levels and did not receive statin therapy.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Kinjo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Daisaku
authors.initials: D
authors.lastname: Nakatani
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mizuno
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shimizu
authors.forename: Masami
authors.initials: M
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Jun
authors.initials: J
authors.lastname: Tanouchi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nanto
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000401:mortality*; D015996:Survival Rate / Q000639:trends
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein