title: Risk factors for neurosurgical site infections after craniotomy: a critical reappraisal of antibiotic prophylaxis on 4,578 patients.
abstract: The objective of this study was to evaluate incidence and risk factors of postoperative infections, with emphasis on antibiotic prophylaxis, in a series of 4578 craniotomies. A prospective database was implemented for surveillance of postcraniotomy infections. During period A, no antibiotic prophylaxis was prescribed for scheduled, clean craniotomies, lasting less than 4 h, whereas emergency, clean-contaminated or long-lasting craniotomies received cloxacillin or amoxicillin-clavulanate. During period B, prophylaxis was given to every craniotomy. The effect of prophylaxis on craniotomy infections, independently of other risk factors, was studied by multivariate analysis. The overall infection rate was 6.6%. CSF leak, male gender, surgical diagnosis, surgeon, early re-operation, surgical duration and absence of prophylaxis were independent risk factors. CSF leak had the highest odds ratio. Antibiotic prophylaxis decreased infection rate from 9.7% down to 5.8% in the entire population (p<0.0001) mainly by decreasing rates in low risk patients from 10.0% down to 4.6% (p<0.0001). Antibiotic prophylaxis in craniotomy is effective in preventing surgical site infections even in low-risk patients.
authors.affiliation: Neuroanaesthesia Unit, Department of Anaesthesiology, Pitié-Salpêtrière Hospital, University of Paris VI, Paris, France. anne.marie.korinek@psl.ap-hop-paris.fr
authors.forename: A-M
authors.initials: AM
authors.lastname: Korinek
authors.forename: J-L
authors.initials: JL
authors.lastname: Golmard
authors.forename: A
authors.initials: A
authors.lastname: Elcheick
authors.forename: R
authors.initials: R
authors.lastname: Bismuth
authors.forename: R
authors.initials: R
authors.lastname: van Effenterre
authors.forename: P
authors.initials: P
authors.lastname: Coriat
authors.forename: L
authors.initials: L
authors.lastname: Puybasset
mesh_terms: D000328:Adult; D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D003023:Cloxacillin / Q000627:therapeutic use; D003399:Craniotomy / Q000009:adverse effects*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000145:classification / Q000453:epidemiology* / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D003023:Cloxacillin