Late-phase long-term potentiation: getting to the nucleus.
New mRNA must be transcribed in order to consolidate changes in synaptic strength. But how are events at the synapse communicated to the nucleus? Some research has shown that proteins can move from activated synapses to the nucleus. However, other work has shown that action potentials can directly inform the nucleus about cellular activation. Here we contend that action potential-induced signalling to the nucleus best meets the requirements of the consolidation of synapse-specific plasticity, which include both timing and stoichiometric constraints.
Adams
J Paige
JP
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
Dudek
Serena M
SM
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology*; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology*; D008959:Models, Neurological; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000502:physiology; D013997:Time Factors