Hemorheological and cerebroprotective activity of Lychnis chalcedonica L. extract in rats with cerebral ischemia.
Considerable hemorheological changes and depression of EEG parameters were revealed in rats with cerebral ischemia. Course peroral treatment with scarlet lightning extract in a daily dose of 150 mg/kg for 5 days reduced the severity of hemorheological disorders. It manifested in a decrease in whole blood viscosity, plasma viscosity, erythrocyte aggregation, and fibrinogen concentration and increase in deformability. The extract of lightning extract improved EEG activity in rats with cerebral ischemia.
Plotnikov
M B
MB
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. oal@pharm.tsu.ru
Aliev
O I
OI
Vasilev
A S
AS
Maslov
M Yu
MY
Suslov
N I
NI
Zibareva
L N
LN
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D001921:Brain / Q000098:blood supply* / Q000187:drug effects / Q000502:physiology; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy*; D004569:Electroencephalography / Q000187:drug effects; D018056:Hemorheology; D031244:Lychnis / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D029751:Silene
D018696:Neuroprotective Agents; D010936:Plant Extracts; C504810:scarlet lightning extract