title: Congenital cystic adenomatoid malformation in the fetus: a hypothesis of its development.
abstract: We present a case of congenital cystic adenomatoid malformation of the lung diagnosed at 34 weeks of gestation in the setting of polyhydramnios. The fetus had CCAM in the L lung, with mediastinal shift to the right and ascites. The neonate underwent drainage of cysts and subsequent left lung lobar resection with improvement in respiratory function. The pathology of CCAM is reviewed in detail. We speculate the role of alcohol as a teratogen through retinoic acid at 8-10 weeks of gestation when fetal lungs are actively developing.
authors.affiliation: Department of Obstetrics and Gynecology, Sloane Hospital for Women, Columbia University Medical Center of New York Presbyterian Hospital and College of Physicians and Surgeons of Columbia University, New York, N.Y. 10032, USA.
authors.forename: Ema
authors.initials: E
authors.lastname: Kulwa
authors.forename: Tessie
authors.initials: T
authors.lastname: Tharakan
authors.forename: Laxmi
authors.initials: L
authors.lastname: Baxi
mesh_terms: D000208:Acute Disease; D000328:Adult; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000000981:diagnostic imaging* / Q000209:etiology*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D006831:Polyhydramnios / Q000000981:diagnostic imaging / Q000209:etiology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014212:Tretinoin / Q000378:metabolism; D016216:Ultrasonography, Prenatal
chemical_list: D014212:Tretinoin