Enhancement of immune responses to an HBV DNA vaccine by electroporation.
These studies document the ability of electroporation (EP)-based DNA vaccination to induce multi-specific CTL responses to hepatitis B virus (HBV) DNA vaccination in normal mice and marked immune responses to multivalent HBV DNA immunization in larger animal species. These results suggest that electroporation-mediated HBV DNA vaccination is worth pursuing as a treatment for chronic HBV infection.
Luxembourg
A
A
Ichor Medical Systems, 6310 Nancy Ridge Drive, Ste 107, San Diego, CA 92121, USA. aluxembourg@ichorms.com
Hannaman
D
D
Ellefsen
B
B
Nakamura
G
G
Bernard
R
R
D000914:Antibodies, Viral / Q000096:biosynthesis; D018274:Electroporation; D017325:Hepatitis B Vaccines / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology*
D000914:Antibodies, Viral; D017325:Hepatitis B Vaccines; D019444:Vaccines, DNA