title: [Anticonvulsant effect of phencynonate hydrochloride on maximal electroshock seizure and the metrazol seizure threshold test in mice].
abstract: OBJECTIVE
  To test the antiepileptic effect of phencynonate hydrochloride and investigate its antiepileptic mechanism.
  
  
  METHODS
  Through establishment of different epilepsy models, antiepileptic effects of phencynonate hydrochloride and other drugs were examined. Besides, the effect of phencynonate hydrochloride and other compounds against NMDA-induced lethality in mice, NMDA-induced injury in rat primary hippocampal neuronal cultures and NMDA-induced current were also observed.
  
  
  RESULTS
  Phencynonate hydrochloride produced a significant anticonvulsant effect on different epilepsy models. Furthermore, phencynonate hydrochloride also exerted its obvious protection against the lethal effects of NMDA in mice, antagonized the NMDA-induced injury in rat primary hippocampal neuronal cultures and blocked NMDA-induced current in a dose-dependent manner.
  
  
  CONCLUSIONS
  Phencynonate hydrochloride had a notable anticonvulsant effect on typical epilepsy models, its antiepileptic mechanism might relate to its antagonism against NMDA receptor.
authors.affiliation: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China. yonganw908@yahoo.com.cn
authors.forename: Yong-An
authors.initials: YA
authors.lastname: Wang
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Zhou
authors.forename: Yan-Qin
authors.initials: YQ
authors.lastname: Liu
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Zheng
authors.forename: Ke-Liang
authors.initials: KL
authors.lastname: Liu
authors.forename: Jin-Xiu
authors.initials: JX
authors.lastname: Ruan
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001372:Aza Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002478:Cells, Cultured; D004597:Electroshock; D005260:Female; D006016:Glycolates / Q000494:pharmacology / Q000627:therapeutic use*; D006624:Hippocampus / Q000166:cytology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D016202:N-Methylaspartate / Q000633:toxicity; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: C504860:3-methyl-3-azabicyclo(3,3,1)nonanyl-9-alpha-yl-alpha-cyclopentyl-alpha-phenyl-alpha-glycolate; D000927:Anticonvulsants; D001372:Aza Compounds; D006016:Glycolates; D018696:Neuroprotective Agents; D016202:N-Methylaspartate; D010433:Pentylenetetrazole