Luteolin inhibits endothelin-1 secretion in cultured endothelial cells.
We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED50 was about 10 microM. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.
Kozakai
Takaharu
T
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Ibaraki, Japan. tkoza@syd.odn.ne.jp
Yamanaka
Akiko
A
Ichiba
Toshio
T
Toyokawa
Tetsuya
T
Kamada
Yasuhiro
Y
Tamamura
Takako
T
Ichimura
Toshiaki
T
Maruyama
Susumu
S
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000235:genetics / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D047311:Luteolin / Q000494:pharmacology*; D013552:Swine
D017931:DNA Primers; D019332:Endothelin-1; D047311:Luteolin