[Expression of transforming growth factor-beta1 in cervical squamous carcinoma cell and stroma].
OBJECTIVE
To explore the significance and expression of transforming growth factor-beta1 (TGFbeta1) in cervical squamous carcinoma.


METHODS
The expression of TGFbeta1 in 31 cases of cervical squamous carcinomas were detected by SP immunohistochemical staining.


RESULTS
TGFbeta1 expression was found in both cytoplasm and extracellular stroma. TGFbeta1 expression increased when the pathologic grade was getting worse and clinical stage was of later the in extracellular matrix and decreased in cytoplasm. The positive rate of TGFbeta1 in cytoplasm in the low grade group was lower than that in the high and middle grade (P < 0.05). The positive rate of TGFbeta1 in extracellular stroma in the high grade group was significantly lower than that of the other two groups. In cytoplasma, the TGFbeta1 expression was obviously higher in stage I than in stage II and III, while it was lower in extracellular stroma (P < 0.05). There was no significant difference between stage II and III (P > 0.05.


CONCLUSIONS
The decrease of TGFbeta1 expression may play an important role in the differentiation and devepolment of cervical squamous carcinoma. High expressions of TGFbeta1 in extracellular stroma may be related to the matastasis of cervical squamous carcinoma.
Li
Xin-Guo
XG
Department of Obstetrics and Gynecology, Central South University, Xiangya Hospital, Changsha 410008, China.
Zou
Xiao-Hui
XH
Zhang
Yu
Y
D000328:Adult; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D053773:Transforming Growth Factor beta1; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
D014408:Biomarkers, Tumor; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1