Biochemical markers and genetic research of ADHD.
ADHD (attention hyperactivity disorder) is a polygenetic disorder with various candidate genes. At this time, more than thirty dopaminergic, noradrenergic, serotonergic and GABA-ergic genes are known. The research of only some candidate genes (DRD4, DAT, DRD5, DBH, 5HTT, HTR1B and SNAP25) brought relatively consistent results confirming the heredity of ADHD syndromes. The results of research of other genes (DRD2, DRD3, MAO, ADR2A, GABA A3, GABA B3) are not clear yet. This paper summarizes the most important genetic data in correlations with biochemical periphery parameters (especially for DBH, HVA, MHPG, serotonin). Hypothetically, certain subgroups of ADHD may be identified by correlation of biochemical characteristics and some candidate genes. The paper discusses some implications for future research. Review.
Paclt
I
I
Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic. pacltovi@email.cz
Koudelová
J
J
Krepelová
A
A
Uhlíková
P
P
Gazdíková
M
M
Bauer
P
P
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000503:physiopathology*; D015415:Biomarkers; D001923:Brain Chemistry / Q000235:genetics; D005819:Genetic Markers; D006801:Humans
D015415:Biomarkers; D005819:Genetic Markers