Nuclear reprogramming by human embryonic stem cells.
Embryonic stem cells have two unique properties. They are capable of indefinite self-renewal and, being pluripotent, they can differentiate into all possible cell types, including germ cells. A new study by Cowan et al. (2005) published in Science shows that human embryonic stem cells are able to reprogram the nuclei of fully differentiated human somatic cells, apparently conferring on them a pluripotent state.
Surani
M Azim
MA
Wellcome Trust Cancer Research UK gordon Institute, University of Cambridge, Cambridge CB2 1QN, UK
D002467:Cell Nucleus / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology*; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*