title: The vicinal F-C-C-F moiety as a tool for influencing peptide conformation.
abstract: Diastereoisomers of bis(amino acid amides) of 2,3-difluorosuccinic acid have been prepared and the erythro- and threo-isomers display very different conformations.
authors.affiliation: School of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, UK. do1@st-and.ac.uk
authors.forename: Martin
authors.initials: M
authors.lastname: Schüler
authors.forename: David
authors.initials: D
authors.lastname: O'hagan
authors.forename: Alexandra M Z
authors.initials: AM
authors.lastname: Slawin
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry; D007202:Indicators and Reagents; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D010455:Peptides; D005461:Fluorine