Pt-catalyzed pentannulations from in situ generated metallo-carbenoids utilizing propargylic esters.
A highly selective and efficient Pt-catalyzed pentannulation reaction beginning from propargylic esters is described. The key to this reaction is the use of a PtCl2(PPh3)2/PhIO catalyst combination that allows the in situ generation of Pt-carbenoid intermediates, which lead to good yields (61-84%) of the desired pentannulated compounds.
Bhanu Prasad
B A
BA
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Yoshimoto
Francis K
FK
Sarpong
Richmond
R
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*
D000480:Alkynes; D004952:Esters; D009944:Organoplatinum Compounds; D010984:Platinum