Rehmannia glutinose ameliorates renal function in the ischemia/reperfusion-induced acute renal failure rats.
The present study was designed to examine whether aqueous extract of steamed root of Rehmannia glutinose (ARR) has an ameliorative effect on renal functional parameters in association with the expressions of aquaporin 2 (AQP 2), Na,K-ATPase, and heme oxygenase-1 (HO-1) in the ischemia-reperfusion induced acute renal failure (ARF) rats. Polyuria caused by down-regulation of renal AQP 2 in the ischemia-induced ARF rats was markedly restored by administration of ARR (200 mg/kg, p.o.) with restoring expression of AQP 2 in the kidney. The expressions of Na,K-ATPase alpha1 and beta1 subunits in the renal medullar and cortex of the ARF rats were also restored in the ARF rats by administration of ARR. On the other hand, administration of ARR lowered the renal expression of HO-1 up-regulated in rats with ischemia-induced ARF. The renal functional parameters including creatinine clearance, urinary sodium excretion, urinary osmolality, and solute-free reabsorption were also markedly restored in ischemia-ARF rats by administration of ARR. Taken together, these data indicate that RSR ameliorates renal defects in rats with ischemia-induced ARF.
Kang
Dae Gill
DG
Professional Graduate School of Oriental Medicine and Medicinal Resources Research Institute (MeRRI), Wonkwang University, Jeonbuk, Republic of Korea.
Sohn
Eun Jin
EJ
Moon
Mi Kyoung
MK
Lee
Yun Mi
YM
Lee
Ho Sub
HS
D058186:Acute Kidney Injury / Q000201:enzymology / Q000503:physiopathology / Q000517:prevention & control*; D000818:Animals; D020346:Aquaporins / Q000096:biosynthesis; D015153:Blotting, Western; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis; D051547:Heme Oxygenase-1; D007677:Kidney Function Tests; D008297:Male; D009336:Necrosis; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D032267:Rehmannia / Q000737:chemistry*; D012079:Renal Circulation / Q000502:physiology; D015427:Reperfusion Injury / Q000201:enzymology / Q000503:physiopathology / Q000517:prevention & control*; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D020346:Aquaporins; D010936:Plant Extracts; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; D000254:Sodium-Potassium-Exchanging ATPase