title: The relation of bone marrow scintigraphy and unilateral bone marrow biopsy in malignant lymphoma.
abstract: To assess the diagnostic role of bone marrow scintigraphy (BMS) for detecting bone marrow infiltration by malignant lymphomas, 47 patients, 14 with malignant Hodgkin's and 33 with non-Hodgkin's lymphoma underwent BMS with 99mTc-sulphur-colloid and also unilateral iliac crest bone marrow biopsy (BMB). BM involvement in BMB was observed in 11 of the 47 patients. Four of these patients also had BMS lesions. Eight patients had BMS lesions not detected by BMB. There was poor agreement between the two modalities (kappa=0.137). Considering BMB as the gold standard, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of BMS were 36%, 77%, 33%, 80%, and 68% respectively. In conclusion, BMS has a high negative predictive value and may be used as a complementary screening test for lymphoma to assess the extent of BM involvement, especially if magnetic resonance imaging-guided biopsy or positron emission tomography studies are not available, as is the case in developing countries.
authors.affiliation: Nuclear Medicine Research Center, Shariati hospital, Tehran University of Medical Sciences, Northern Kargar St, 14114 Tehran, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Esmaili
authors.forename: Seyyed Reza
authors.initials: SR
authors.lastname: Safaee
authors.forename: Ramezanali
authors.initials: R
authors.lastname: Sharifian
authors.forename: Shahin
authors.initials: S
authors.lastname: Shoeybi
authors.forename: Ali
authors.initials: A
authors.lastname: Gholamrezanezhad
mesh_terms: D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid