title: Actin and myosin I in the nucleus: what next?
abstract: Several recent publications have demonstrated the importance of nuclear actin and nuclear myosin I in transcription. Here we review these publications and their implications. In addition, we discuss some important issues that should be addressed to gain a more comprehensive understanding of how these traditionally 'cytoplasmic' proteins are involved in transcription. We propose highly speculative models and mechanisms solely to stimulate thought and experimentation in this area.
authors.affiliation: the Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois 60612, USA. primal@uic.edu
authors.forename: Primal
authors.initials: P
authors.lastname: de Lanerolle
authors.forename: Terazina
authors.initials: T
authors.lastname: Johnson
authors.forename: Wilma A
authors.initials: WA
authors.lastname: Hofmann
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006801:Humans; D024461:Myosin Type I / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D000199:Actins; D012321:DNA-Directed RNA Polymerases; D024461:Myosin Type I