Radiolabelling and biodistribution of 111In-antimony trisulphide colloid.
The aim of this study was to prepare 111In-antimony trisulphide colloid (111In-ATC) and evaluate its chemical properties in comparison with 99mTc-ATC. After reconstitution of an antimony trisulphide cold Kit with 111In-chloride, 111In-ATC was formed with >95% radiochemical purity in the presence of neutralising phosphate buffer. The product was found to be stable for 4.7 days when stored at room temperature, 80% of radioactive particles were < 20 nm in diameter and the mouse biodistribution assay was identical to that of 99mTc-ATC. In conclusion, pharmaceutical-grade 111In-ATC was successfully prepared and assessed to have properties that are suitable for dual-isotope lymphoscintigraphy studies at the clinical level.
Tsopelas
Chris
C
RAH Radiopharmacy, Royal Adelaide Hospital, Nuclear Medicine Department, North Terrace, Adelaide, 5000, Australia. ctsopela@mail.rah.sa.gov.au
Cooper
Robert
R
D000818:Animals; D000965:Antimony / Q000737:chemistry* / Q000493:pharmacokinetics*; D003102:Colloids / Q000737:chemistry* / Q000493:pharmacokinetics*; D004355:Drug Stability; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D010316:Particle Size; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism*; D017556:Technetium Compounds / Q000493:pharmacokinetics; D014018:Tissue Distribution
D003102:Colloids; D019275:Radiopharmaceuticals; D017556:Technetium Compounds; C019096:technetium Tc 99m antimony sulfide; D000965:Antimony