188Rhenium(V)-dimercaptosuccinic acid loaded poly(lactic-co-glycolic)acid microspheres for targeted radiotherapy: production and effectivity.
Poly(lactic-co glycolic)acid (75:25) (PLGA) microspheres for the delivery of a radiation dose to tumors were synthesized after loading the 188Re(V) labeled DMSA. The 188ReO4- in place of 99mTcO4- was replaced to label DMSA, because of their structural and chemical similarities and to make the molecule site specific for radiotherapy. The radiolabeling efficiency of DMSA was more than 97% as confirmed by ITLC. A solvent evaporation technique was used to encapsulate DMSA in PLGA microspheres. Electron microscopy demonstrated the microspheres size ranged between 0.4-1.8 microm. As demonstrated by DSC, DMSA was encapsulated (20-30%) within the microspheres in solid solution, metastable molecular dispersion or crystallization forms. In vitro release studies confirmed the stability of DMSA.
Shukla
J
J
Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, N. Delhi, India.
Bandopadhyaya
G P
GP
Varma
I K
IK
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005079:Excipients; D019344:Lactic Acid; D008854:Microscopy, Electron; D008863:Microspheres; D009942:Organometallic Compounds / Q000737:chemistry*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000737:chemistry*; D011878:Radiotherapy; D012211:Rhenium; D013055:Spectrophotometry, Infrared; D004113:Succimer / Q000737:chemistry*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D005079:Excipients; D009942:Organometallic Compounds; D011108:Polymers; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C069609:rhenium(V)dimercaptosuccinic acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D012211:Rhenium; D004113:Succimer