title: [Prevalence of Epstein-Barr virus in non-Hodgkin's lymphomas in central region of Tunisia].
abstract: The purpose of this study was to evaluate the prevalence of EBV in non-Hodgkin's lymphomas occuring in non-immunocopromised patients in Tunisia through a series of 126 cases. EBV was investigated by EBER oligonucleotide in situ hybridization (ISH) and LMP1-immunohistochemistry. Serological study of EBV has been performed before therapy in 28 patients. EBV was detected in tumor cells by ISH in 28/126 (22.2%) cases. Variable proportions of tumor cells were positive. LMP1 was identified in only 8 cases. EBV was more frequently observed in T-cell lymphomas (9/24 patients; 37.5%) than in B-cell lymphomas (19/102 patients; 18.6%) (p=0.04). There was a strong relationship between EBV and small intestine lymphomas (6/8 patients; 75%) and T/NK nasal type lymphomas (3/3 patients; 100%). EBV serological reactivation was noted in 7/13 patients in clinical stages III/IV and in only 1/10 patients in stages I/II (p=0.03). In conclusion, the prevalence of EBV in Tunisian non-Hodgkin's lymphomas is low but variable depending on the histological type and anatomical location with a predilection for small intestine and nasal lymphomas.
authors.affiliation: Laboratoire d'Anatomie et de Cytologie Pathologiques, CHU Farhat Hached, 4000 Sousse, Tunisia.
authors.forename: Mounir
authors.initials: M
authors.lastname: Trimeche
authors.forename: Sonia
authors.initials: S
authors.lastname: Ziadi
authors.forename: Laurence
authors.initials: L
authors.lastname: De Leval
authors.forename: Sihem
authors.initials: S
authors.lastname: Hmissa
authors.forename: Badredine
authors.initials: B
authors.lastname: Sriha
authors.forename: Moncef
authors.initials: M
authors.lastname: Mokni
authors.forename: Intissar
authors.initials: I
authors.lastname: Toumi
authors.forename: Halima
authors.initials: H
authors.lastname: Elomri
authors.forename: Adnène
authors.initials: A
authors.lastname: Laatiri
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Kehlif
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
authors.forename: Sadok
authors.initials: S
authors.lastname: Korbi
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D005843:Geography; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D014416:Tunisia / Q000453:epidemiology