title: In vivo efficacy study of quinine sulphate in the treatment of uncomplicated P. falciparum malaria in patients from Southwestern Cameroon.
abstract: OBJECTIVE
  To evaluate clinical, parasitological and haematological responses to quinine sulphate therapy in patients with uncomplicated malaria using the 14-day WHO protocol.
  
  
  METHODS
  Longitudinal study.
  
  
  METHODS
  The Buea Provincial hospital annex located in South Western Cameroon.
  
  
  METHODS
  The study participants consisted of children (> or = 8 months) and adults (< or = 550 years) with acute malaria attending the outpatient division of health institutions within Fako Division.
  
  
  RESULTS
  Quinine sulphate failure was found in 42% of the patients. Of these 10% were resistant at the RI while 32% were at the RII level. Clinically, the overall success rate (ACR) was 94.2% while therapeutic failures (ETF and LTF) were observed in four patients (5.8%). 27.4% and 17.4% of the patients were anaemic at enrolment and day 14 respectively. The mean PCV levels of the patients increased during the follow-up period except on day three when mean PCV levels dropped. The difference in the mean PCV levels during the follow-up was significant (F = 60.29; P = 0.0001).
  
  
  CONCLUSIONS
  The relatively high resistance of quinine sulphate observed in this study suggests the need to monitor the spread of resistance to this drug in the study region.
authors.affiliation: Faculty of Health Sciences, University of Buea, P.O. Box 63 Buea, Cameroon.
authors.forename: E A
authors.initials: EA
authors.lastname: Achidi
authors.forename: A
authors.initials: A
authors.lastname: Ajua
authors.forename: H K
authors.initials: HK
authors.lastname: Kimbi
authors.forename: C M
authors.initials: CM
authors.lastname: Sinju
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011803:Quinine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D011803:Quinine