title: [Expression of p27 in renal interstital fibrosis in rats induced by unilateral ureteral obstruction].
abstract: OBJECTIVE
  To explore the role of p27 in the renal tubule on the process of renal interstitial fibrosis caused by unilateral ureteral obstruction (UUO) in rats.
  
  
  METHODS
  Rats were killed at the 7th, 14th, 21st days after UUO or sham-surgery. The protein expression of p27 in renal tubule was detected by immuohistochemistry at each time point.
  
  
  RESULTS
  At the 7th day after the surgery, no noticeable abnormalities of p27 expression were found in renal tubular cells between UUO and the sham operated surgery. At the 14th and 21st days after UUO, the p27 expressions in renal tubular cells obviously decreased compared with those after the sham operated surgery.
  
  
  CONCLUSIONS
  The p27 expression has no noticeable changes in the early UUO rats, and then it was significantly reduced with the renal interstitial fibrosis progressing.
authors.affiliation: Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Tao
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Ou
authors.initials: O
authors.lastname: Jin
mesh_terms: D000818:Animals; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D007684:Kidney Tubules / Q000378:metabolism; D009400:Nephrosclerosis / Q000209:etiology / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014517:Ureteral Obstruction / Q000150:complications*
chemical_list: D050760:Cyclin-Dependent Kinase Inhibitor p27