[Drug-associated interstitial lung disease: a diagnostic challenge].
Drugs are frequently incriminated as the cause of interstitial pneumonia. There are two major mechanisms of drug-associated interstitial lung disease: direct toxicity and immunoallergic reaction. When a drug is suspected, the difficulty lies in obtaining proof. The chronology of the disease and its manifestations together with earlier evidence reported in the literature can lead to a tentative diagnosis of drug-associated interstitial pneumonia. Proof is obtained through surveillance during the disease course. In nearly all patients, therapeutic decisions must be taken on the basis of suspected drug involvement.
Mayaud
Charles
C
Service de Pneumologie, Hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris. charles.mayaud@tnn.aphp.fr
Fartoukh
Muriel
M
Parrot
Antoine
A
Cadranel
Jacques
J
Milleron
Bernard
B
Akoun
Georges
G
D018893:Bronchoalveolar Lavage; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*