title: Height and body mass index in relation to colorectal and gallbladder cancer in two million Norwegian men and women.
abstract: OBJECTIVE
  The present study aimed at exploring the relations between BMI and stature and colorectal and gallbladder cancer in a huge Norwegian cohort with measured height and weight.
  
  
  METHODS
  Height and weight were measured in two million Norwegian men and women aged 20-74 during 1963-2001. During follow-up, 47,117 colorectal and 1715 gallbladder cancer cases were registered. Relative risks (RRs) of colorectal and gallbladder cancer were estimated using Cox proportional hazards regression.
  
  
  RESULTS
  The risk of colon cancer increased with increasing BMI in men; the RR of colon cancer per unit increase in BMI was 1.04 (95% CI: 1.04-1.05). For mucinous colorectal adenocarcinomas, the risk increased to a larger extent with increasing BMI in both sexes. The RR of colorectal cancer associated with 10 cm increase in height was 1.14 (95% CI: 1.11-1.16) in men and 1.17 (95% CI: 1.14-1.20) in women. The risk of gallbladder cancer increased with increasing BMI in women; the overall RR associated with one unit increase in BMI was 1.06 (95% CI: 1.04-1.07). There was no association between height and gallbladder cancer in either sex.
  
  
  CONCLUSIONS
  The risk of colon cancer increased with increasing BMI in men, and the risk of gallbladder cancer increased with increasing BMI in women. In both sexes, the risk of colon cancer increased with increasing height.
authors.affiliation: Division of Epidemiology, Norwegian Institute of Public Health, P.O. Box 4404, N-0403 Nydalen, Oslo, Norway. anders.engeland@fhi.no
authors.forename: Anders
authors.initials: A
authors.lastname: Engeland
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
authors.forename: Gunnar
authors.initials: G
authors.lastname: Austad
authors.forename: Tone
authors.initials: T
authors.lastname: Bjørge
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D005706:Gallbladder Neoplasms / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009664:Norway / Q000453:epidemiology; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors