[Dietary fatty acids and cancer: potential cellular and molecular mechanisms].
Experimental evidence indicates that n-3 fatty acids, especially the long-chain polyunsaturated fatty acids, unlike n-6 fatty acids could prevent cancer development. This survey shows that fatty acids could act through several mechanisms including the production of reactive oxygen species, the modulation of gene expression and signal transduction pathways, or the eicosanoid biosynthesis. Human genetics has underlined several polymorphisms in genes identified as possible targets of fatty acids which suggests that the link between nutritional intake and cancer prevention, especially the eventual anti-carcinogenic effects of n-3 fatty acids, depends on the genetic background. Further studies are needed to evaluate the effects of fatty acids on angiogenesis which represents a marker of a poor prognosis in cancer. Finally, the use of genomic technologies combined with nutritional strategies could provide a more understanding of the effects of n-3 fatty acid intake on cancer prevention.
Bardon
Sylvie
S
Laboratoire de nutrition et sécurité alimentaire INRA CRJ, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex. duee@paris.inra.fr
Benelli
Chantal
C
Bernard-Gallon
Dominique
D
Blottière
Hervé
H
Demarquoy
Jean
J
Duée
Pierre-Henri
PH
Forest
Claude
C
D000273:Adipose Tissue / Q000378:metabolism; D017209:Apoptosis; D051546:Cyclooxygenase 2; D004249:DNA Damage; D004041:Dietary Fats / Q000378:metabolism*; D005502:Food; D005786:Gene Expression Regulation; D019787:Linoleic Acid / Q000378:metabolism; D015227:Lipid Peroxidation; D009369:Neoplasms / Q000098:blood supply / Q000209:etiology* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000209:etiology; D020025:Peroxisome Proliferators / Q000378:metabolism; D011110:Polymorphism, Genetic; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction
D004041:Dietary Fats; D020025:Peroxisome Proliferators; D019787:Linoleic Acid; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D011494:Protein Kinases