title: Recurrent pleomorphic adenoma of the parotid gland.
abstract: OBJECTIVE
  To assess the long-term results in the management of 42 patients with recurrent pleomorphic adenoma of the parotid gland.
  
  
  METHODS
  A retrospective analysis of 42 patients who underwent parotidectomy for recurrent pleomorphic adenoma was performed to study presenting clinicoradiographic features, surgical technique, facial nerve management, and the long-term risk of recurrence.
  
  
  RESULTS
  All 42 patients had multi-focal, nontender recurrent nodules following one to four prior surgical procedures and 6 patients underwent prior radiotherapy. Surgical procedures included subtotal parotidectomy in 12 patients, total parotidectomy in 18 patients, parotidectomy with facial nerve resection in 7 cases, and subtotal petrosectomy with facial nerve resection in 5 individuals. The 2 patients with malignant transformation died of disseminated lung and bone metastasis. Twenty-nine of the remaining 40 patients had no recurrent disease. Seven patients developed local parotid bed or cutaneous recurrent disease, 2 patients died of unrelated causes, and 2 patients were lost to follow-up.
  
  
  CONCLUSIONS
  All 7 patients with recurrent disease underwent subtotal parotidectomy with "negative" surgical margins. Total parotidectomy or subtotal petrosectomy with facial nerve resection in selected cases may reduce the risk of multiple episodes of pleomorphic adenoma recurrence. Two of 42 patients were found to have carcinoma ex-pleomorphic adenoma, both of these patients underwent prior radiotherapy, and both died of metastatic disease.
authors.affiliation: Loyola Center for Cranial Base Surgery, Maywood, IL 60153, USA. jleonet@kumc.edu
authors.forename: John P
authors.initials: JP
authors.lastname: Leonetti
authors.forename: Sam J
authors.initials: SJ
authors.lastname: Marzo
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Petruzzelli
authors.forename: Brian
authors.initials: B
authors.lastname: Herr
mesh_terms: D008949:Adenoma, Pleomorphic / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D005154:Facial Nerve / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010307:Parotid Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D010579:Petrous Bone / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D013497:Sural Nerve / Q000637:transplantation; D015996:Survival Rate; D014182:Transplantation, Autologous