Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.
The vesicular monoamine transporter (VMAT2) is important in the storage and release of monoamines. Platelet VMAT2 was characterized using high-affinity [(3)H]dihydrotetrabenazine ([(3)H]TBZOH) binding in untreated social phobia (SP) patients (n=20) compared with sex- and age-matched healthy controls (n=15). No significant differences in VMAT2 density (B(max)) and affinity constants (K(d)) were observed.
Laufer
Neil
N
Geha Psychiatric Hospital and Felsenstein Medical Research Center, Beilinson Campus, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Zucker
Michal
M
Hermesh
Haggai
H
Marom
Sofi
S
Gilad
Royi
R
Nir
Vered
V
Weizman
Abraham
A
Rehavi
Moshe
M
D000328:Adult; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D002452:Cell Count; D005260:Female; D006801:Humans; D008297:Male; D010698:Phobic Disorders / Q000175:diagnosis* / Q000378:metabolism*; D011795:Surveys and Questionnaires; D013747:Tetrabenazine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D050493:Vesicular Monoamine Transport Proteins / Q000097:blood* / Q000378:metabolism
C493452:SLC18A2 protein, human; D050493:Vesicular Monoamine Transport Proteins; C032811:dihydrotetrabenazine; D013747:Tetrabenazine