Effect of granulocyte colony-stimulating factor on kinetics of hemopoietic precursors in regenerating bone marrow.
We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors and increased content of DNA-synthesizing CFU-GM in the bone marrow.
Goldberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Dygai
A M
AM
Zhdanov
V V
VV
Guryantseva
L A
LA
Udut
E V
EV
Popova
N O
NO
Simanina
E V
EV
Khrichkova
T Yu
TY
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D051379:Mice; D012038:Regeneration; D013234:Stem Cells
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide