Efficacy assessment of CellSlide in liquid-based gynecologic cytology.
OBJECTIVE
To evaluate the efficacy of CellSlidetrade mark (CS) method in liquid-based gynecologic cytology.


METHODS
We compared 1221 specimens prepared by both CS and conventional techniques to evaluate specimen adequacy and cytologic diagnoses. Sensitivity and specificity of these techniques were analyzed in 54 cases using the available histological data.


RESULTS
Quality limiting factors, such as obscuring inflammation or blood, were markedly reduced in CS (0.2%) compared to the conventional smear (4.9%). There was a complete agreement in the Bethesda 2001 diagnosis between these methods in 1132 cases (92.7%) out of 1221. 16.7% more ASC cases and 37.5% more low-grade squamous intraepithelial lesions (LSIL) and 21.4% more high-grade SIL (HSIL) were detected on the CS slides than on the conventional smears. Sensitivity rates, relative to histological data, were 91.4% (CS) and 74.3% (conventional) and specificity rates were same (89.5%) for ASC and more severe lesions. Infectious organisms (Trichomonas and Candida, etc.) were readily identifiable in both methods.


CONCLUSIONS
CS preparation is more sensitive and equally specific in detecting epithelial abnormalities when compared to the conventional smear. In addition, it has a lower incidence of unsatisfactory results with hypocellularity or >75% obscuration of cells.
Chung
Jae-Hun
JH
Department of Pathology, Chonnam National University Hospital, 5 Hak-dong, Dong-gu, Gwangju 501-190, Korea.
Park
Eun-Jung
EJ
Choi
Yoo-Duk
YD
Kim
Hyung-Seok
HS
Lee
Young-Jik
YJ
Ko
Hyang-Mi
HM
Kim
Kyung-Soo
KS
Nam
Jong-Hee
JH
Park
Chang-Soo
CS
D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D002584:Cervix Uteri / Q000166:cytology* / Q000473:pathology; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology; D014626:Vaginal Smears / Q000379:methods* / Q000592:standards; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology