title: Color-dilution alopecia in dogs.
abstract: Color-dilution alopecia is a relatively uncommon hereditary skin disease seen in "Blue" and other color-diluted dogs. This syndrome is associated with a color-dilution gene. The initial clinical signs are the gradual onset of a dry, dull and poor hair coat quality. Hair shafts and hair regrowth are poor, and follicular papules may develop and progress to frank comedones. Hair loss and comedo formation are usually most severe on the trunk, especially color-diluted area on the skin. Six cases of color-dilution alopecia are reported in 3 months to 10 years old dogs. The breeds of dogs are blue Doberman Pinscher, Miniature Pinscher, Dachshund, and Schnauzer. Grossly, extensive partial hair loss was seen on the skin. Histopathologically, the epidermis is relatively normal but may be hyperplastic. Hair follicles are characterized by atrophy and distortion. Heavily clumped melanin is present in the epidermis, dermis and hair follicles.
authors.affiliation: Department of Veterinary Medicine, Cheju National University, Jeju, Korea. kimjhoon@cheju.ac.kr
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Kyung Il
authors.initials: KI
authors.lastname: Kang
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Sohn
authors.forename: Gye Hyeong
authors.initials: GH
authors.lastname: Woo
authors.forename: Young Hwa
authors.initials: YH
authors.lastname: Jean
authors.forename: Eui Kyung
authors.initials: EK
authors.lastname: Hwang
mesh_terms: D000505:Alopecia / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D006200:Hair Color / Q000235:genetics*; D008297:Male; D012867:Skin / Q000473:pathology