title: Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats.
abstract: Possible effects of 1439 MHz electromagnetic near field (EMF) exposure on the blood-brain barrier (BBB) were investigated using immature (4 weeks old) and young (10 weeks old) rats, equivalent in age to the time when the BBB development is completed and the young adult, respectively. Alteration of BBB related genes, such as those encoding p-glycoprotein, aquaporin-4, and claudin-5, was assessed at the protein and mRNA levels in the brain after local exposure of the head to EMF at 0, 2, and 6 W/kg specific energy absorption rates (SARs) for 90 min/day for 1 or 2 weeks. Although expression of the 3 genes was clearly decreased after administration of 1,3-dinitrobenzene (DNB) as a positive control, when compared with the control values, there were no pathologically relevant differences with the EMF at any exposure levels at either age. Vascular permeability, monitored with reference to transfer of FITC-dextran, FD20, was not affected by EMF exposure. Thus, these findings suggest that local exposure of the head to 1439 MHz EMF exerts no adverse effects on the BBB in immature and young rats.
authors.affiliation: Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kuribayashi
authors.forename: Jianqing
authors.initials: J
authors.lastname: Wang
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujiwara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Doi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nabae
authors.forename: Seiko
authors.initials: S
authors.lastname: Tamano
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ogiso
authors.forename: Makoto
authors.initials: M
authors.lastname: Asamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shirai
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000375:Aging / Q000502:physiology* / Q000528:radiation effects; D000818:Animals; D051401:Aquaporin 4 / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000502:physiology* / Q000528:radiation effects; D002199:Capillary Permeability / Q000502:physiology* / Q000528:radiation effects; D002463:Cell Membrane Permeability / Q000502:physiology / Q000528:radiation effects; D040421:Cell Phone; D002478:Cells, Cultured; D062507:Claudin-5; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008872:Microwaves; D011829:Radiation Dosage; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; C496032:Aqp4 protein, rat; D051401:Aquaporin 4; D062507:Claudin-5; C491510:Cldn5 protein, rat; D008565:Membrane Proteins