Cisapride may improve feeding tolerance of preterm infants: a randomized placebo-controlled trial.
To evaluate the efficacy of cisapride in improving tolerance of enteral feeding, 59 premature infants were randomized into a blinded placebo-controlled study. Treatment was initiated with the introduction of enteral feeding and continued until 150 ml/kg/day of milk were tolerated. Only in extremely low birth weight (ELBW) infants, was the time to tolerate full enteral feeding shorter in the treatment group, whereas ECG recordings showed a significantly prolonged QTc interval during treatment. Two children developed cardiac rhythm disturbances. In conclusion premature infants may not benefit from routine use of the drug to improve enteral feeding, and seem to be more vulnerable to its side effects.
Kohl
Martina
M
Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Germany. kohl@paedia.ukl.mu-luebeck.de
Wuerdemann
Iris
I
Clemen
Jessica
J
Iven
Heiko
H
Katalinic
Alexander
A
Moeller
Jens C
JC
D001724:Birth Weight; D020117:Cisapride / Q000009:adverse effects / Q000627:therapeutic use*; D004066:Digestive System Diseases / Q000188:drug therapy*; D004562:Electrocardiography; D004750:Enteral Nutrition; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005772:Gastrointestinal Transit; D006801:Humans; D041943:Infant Formula; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D008895:Milk, Human; D010919:Placebos; D013997:Time Factors; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D010919:Placebos; D020117:Cisapride