Effects of selected polybrominated diphenyl ether flame retardants on lake trout (Salvelinus namaycush).
Polybrominated diphenyl ether (PBDE) flame-retardants have been identified as an emergent contaminants issue in many parts of the world. In vitro analyses were conducted to test the hypothesis that selected PBDEs congeners affect viability, apoptosis, and necrosis of thymocytes from laboratory-reared lake trout (Salvelinus namaycush). At current environmental levels (< 1 mg/L), effects of the tested PBDEs on thymocytes were negligible. However, at 100 mg/L, major effects were seen for congener brominated diphenyl ether 47 (BDE-47) and minor effects were seen for congener BDE-99.
Birchmeier
Kelly L
KL
Department of Environmental Health Science, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
Smith
Kimberly A
KA
Passino-Reader
Dora R
DR
Sweet
Leonard I
LI
Chernyak
Sergei M
SM
Adams
Jean V
JV
Omann
Geneva M
GM
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D005411:Flame Retardants / Q000032:analysis / Q000633:toxicity*; D006114:Great Lakes Region; D055768:Halogenated Diphenyl Ethers; D009336:Necrosis / Q000139:chemically induced; D010647:Phenyl Ethers / Q000032:analysis / Q000633:toxicity*; D011075:Polybrominated Biphenyls / Q000032:analysis / Q000633:toxicity*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D014337:Trout
D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C086401:pentabromodiphenyl ether