title: Effect of normal saline bolus on cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage.
abstract: OBJECTIVE
  Arterial vasospasm is the most common cause of delayed ischemic neurological deficits (DINDs) and one of the major causes of disability following subarachnoid hemorrhage (SAH). Current management of vasospasm involves intravascular volume expansion and hemodynamic augmentation with the goal of increasing cerebral blood flow (CBF). The purpose of this study was to examine the effects of volume expansion on regional (r)CBF in patients with DIND following SAH.
  
  
  METHODS
  The authors measured quantitative rCBF on positron emission tomography (PET) scans in six patients with aneurysmal SAH who had developed clinical signs of vasospasm. All patients were kept in a euvolemic state prior to the onset of vasospasm. At the onset of vasospasm, global and rCBF were measured before and after the administration of a normal saline bolus of 15 ml/kg administered over 1 hour. Two patients then received saline infusions of 5 ml/kg x hr over the following 2 to 3 hours and underwent hourly serial CBF measurements. Global and rCBF data were calculated in each patient. The mean rCBF in areas with low flow at baseline (< or = 25 ml/[100 g x min]) increased from 19.1 +/- 3.0 to 29.9 +/- 9.7 ml/(100 g x min) (p = 0.02) with volume expansion. This change was sustained over the following 2 to 3 hours. Pulmonary capillary wedge pressure, mean arterial blood pressure, cardiac output, and central venous pressure did not change significantly during this intervention.
  
  
  CONCLUSIONS
  In euvolemic patients with vasospasm, intravascular volume expansion with a normal saline bolus raised CBF in regions of the brain most vulnerable to ischemia.
authors.affiliation: Department of Neurology, Neurological Surgery, and Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Jost
authors.forename: Michael N
authors.initials: MN
authors.lastname: Diringer
authors.forename: Allyson R
authors.initials: AR
authors.lastname: Zazulia
authors.forename: Tom O
authors.initials: TO
authors.lastname: Videen
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Aiyagari
authors.forename: Robert L
authors.initials: RL
authors.lastname: Grubb
authors.forename: William J
authors.initials: WJ
authors.lastname: Powers
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012965:Sodium Chloride / Q000008:administration & dosage*; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*
chemical_list: D012965:Sodium Chloride