title: Total assignment of the (1)H- and (13)C-NMR spectra for TZT-1027 and related compounds.
abstract: The total assignment of the (1)H- and (13)C-NMR spectra for TZT-1027 was carried out using various NMR methods (1D, 2D NMR). It was found that TZT-1027 exists in two different conformations resulting from the cis-trans isomerization of the amide bond at N-11 and C-12 in DMSO-d(6). The (1)H- and (13)C-NMR spectra of compound 1 and 2 comprised of the partial structure of TZT-1027 were also assigned to be TZT-1027. These assignments showed that compound 1 is in good agreement with TZT-1027 with regard to formation of the conformers.
authors.affiliation: Teikoku Hormone Mfg. Co., Ltd.; 1604 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa 213-8522, Japan. uchida-h@teikoku-hormone.co.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchida
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Keino
authors.forename: Toshimi
authors.initials: T
authors.lastname: Seki
authors.forename: Koichi
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Shiraiwa
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D004121:Dimethyl Sulfoxide; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009842:Oligopeptides; C105791:soblidotin; D004121:Dimethyl Sulfoxide