Gleason grading of prostate carcinoma in needle biopsies vs. radical prostatectomy specimens.
The Gleason grading system for prostatic carcinoma is the dominant method used around the world in research and in daily practice. It is based on glandular architecture. The grading system should be applied to all prostatic tissue samples, including needle core biopsies and radical prostatectomy specimens. Its prognostic value was tested in a large population with long-term follow-up that included use of survival as an end point. The Gleason grading system shows a reasonable degree of correlation between biopsy and radical prostatectomy specimens. Several sources of discrepancy between these 2 types of specimen have been identified. Further educational endeavors are needed to arrive at a greater consensus and accuracy in the use of the Gleason system.
Mazzucchelli
Roberta
R
Section of Pathological Anatomy and Histopathology, Institute of Urology, School of Medicine, Polytechnic University of the Marche Region, Ancona, Italy. rmaz@libero.it
Barbisan
Francesca
F
Tarquini
Lucia M
LM
Filosa
Alessandra
A
Campanini
Nicoletta
N
Galosi
Andrea B
AB
D000230:Adenocarcinoma / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D001706:Biopsy; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D011379:Prognosis; D011467:Prostate / Q000473:pathology / Q000601:surgery; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology*