Hepatoprotective activity of Leucas hirta against CCl4 induced hepatic damage in rats.
Methanol and aqueous leaf extracts of L. hirta demonstrated hepatoprotective activity against carbon tetrachloride induced liver damage in rats. The parameters studied were serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Results of the biochemical studies of blood samples of CCl4 treated animals showed significant increase in the levels of serum markers and decrease in total protein level reflecting the liver injury caused by CCl4. Whereas blood samples from the animals treated with methanol and aqueous leaf extracts showed significant decrease in the levels of serum markers and increase in total protein indicating the protection of hepatic cells. The results revealed that methanol leaf extract followed by aqueous extract of L. hirta could afford significant protection against CCl4 induced hepatocellular injury.
Manjunatha
B K
BK
Department of Botany, S.R.N.M.N. College of Applied Sciences, Shimoga 577 201, India. doctor_bkm@yahoo.com
Vidya
S M
SM
Dhiman
Promilla
P
Pallavi
R
R
Mankani
K L
KL
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D006520:Hepatitis, Animal / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D019686:Lamiaceae / Q000737:chemistry*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D020011:Protective Agents; D002251:Carbon Tetrachloride