title: Potential mutagenicity, embryotoxicity, and teratogenicity of calcium ketopantoyl aminobutyrate.
abstract: We studied mutagenic, embryotoxic, and teratogenic properties of calcium ketopantoyl aminobutyrate, a preparation proposed as a new drug. Long-term oral administration of calcium ketopantoyl aminobutyrate produced no mutagenic, embryotoxic, and teratogenic effects.
authors.affiliation: Laboratory of Pharmacology, State Research Institute of Vitamins, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Karaev
authors.forename: I D
authors.initials: ID
authors.lastname: Treshchalin
authors.forename: D A
authors.initials: DA
authors.lastname: Bodyagin
authors.forename: E R
authors.initials: ER
authors.lastname: Pereverzeva
authors.forename: G S
authors.initials: GS
authors.lastname: Kozlova
authors.forename: V I
authors.initials: VI
authors.lastname: Gunar
authors.forename: Yu A
authors.initials: YA
authors.lastname: Revazova
authors.forename: V V
authors.initials: VV
authors.lastname: Yurchenko
mesh_terms: D000014:Abnormalities, Drug-Induced; D000613:Aminobutyrates / Q000633:toxicity*; D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D018697:Nootropic Agents / Q000633:toxicity*; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D011247:Pregnancy
chemical_list: D000613:Aminobutyrates; D009153:Mutagens; D018697:Nootropic Agents; C504809:ketopantoyl aminobutyric acid; D010205:Pantothenic Acid