title: Impact and temporal trends of percutaneous coronary intervention in the drug-eluting stent versus bare metal stent eras.
abstract: Limited published data exist about how the introduction of drug-eluting stents (DESs) has affected the technical aspects of percutaneous coronary intervention and in-hospital patient outcomes in clinical practice. A total of 2,215 consecutive patients who underwent percutaneous coronary intervention for de novo coronary artery disease were divided into 2 cohorts: the pre-DES era (May 1, 2002 to April 30, 2003) and the DES era (May 1, 2003 to April 30, 2004). The procedural success rates (94.9% vs 96.4%, respectively; p = 0.075) and the in-hospital major adverse events (6.4% vs 5.7%, respectively; p = 0.53) were similar between the pre-DES and DES eras. The DES percentage of use increased from 49.5% in the first quarter to 84.1% in the final quarter of the first year after the introduction of this technology (p <0.0001). The results of our study have shown that despite more complex percutaneous coronary intervention procedures with tendencies for more complete lesion coverage and anatomic revascularization, the procedural success and in-hospital outcomes have been comparable since the introduction of DESs.
authors.affiliation: Cardiology Section, Dartmouth Hitchcock Medical Center, Dartmouth Medical School, Lebanon, New Hampshire, USA. Craig.A.Thompson@Dartmouth.edu
authors.forename: Craig A
authors.initials: CA
authors.lastname: Thompson
authors.forename: Aaron V
authors.initials: AV
authors.lastname: Kaplan
authors.forename: John E
authors.initials: JE
authors.lastname: Jayne
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Friedman
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hettleman
authors.forename: Nathaniel W
authors.initials: NW
authors.lastname: Niles
authors.forename: John F
authors.initials: JF
authors.lastname: Robb
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008670:Metals; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D020099:Coated Materials, Biocompatible; D008670:Metals