title: Recovery from bispectral index-guided anaesthesia in a large randomized controlled trial of patients at high risk of awareness.
abstract: Electroencephalographic monitors of anaesthetic depth are reported to assist anaesthetists in reducing recovery times. We explored the effect of bispectral index (BIS) monitoring on recovery times in a double-blind, randomized controlled trial of 2,463 patients at high risk of awareness. Patients were randomized to BIS-guided anaesthesia or routine care. In the BIS group, anaesthesia was adjusted to maintain a BIS value of 40-60 from the commencement of laryngoscopy to the start of wound closure, and 55-70 during wound closure. In the routine care group, anaesthesia was adjusted according to traditional clinical signs. In multivariate models, BIS monitoring, female gender, lower American Society of Anesthesiologists' physical status and shorter duration of anaesthesia predicted faster time to eye-opening after anaesthesia, and faster time to post-anaesthesia care unit discharge. BIS monitoring did not affect times to tracheal extubation among patients admitted to the intensive care unit. We conclude that BIS monitoring has statistically significant, but clinically modest, effects on recovery times in high risk surgical patients.
authors.affiliation: Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, Vic.
authors.forename: K
authors.initials: K
authors.lastname: Leslie
authors.forename: P S
authors.initials: PS
authors.lastname: Myles
authors.forename: A
authors.initials: A
authors.lastname: Forbes
authors.forename: M T V
authors.initials: MT
authors.lastname: Chan
authors.forename: T G
authors.initials: TG
authors.lastname: Short
authors.forename: S K
authors.initials: SK
authors.lastname: Swallow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000758:Anesthesia / Q000379:methods*; D000762:Anesthesia Recovery Period; D001364:Awareness / Q000187:drug effects*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006304:Health Status; D006801:Humans; D007442:Intubation, Intratracheal / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D015999:Multivariate Analysis; D012306:Risk; D012737:Sex Factors; D013997:Time Factors