title: Comparative genomic hybridisation identifies two variants of smoldering multiple myeloma.
abstract: Two variants of smoldering multiple myeloma (SMM) have been recognised: (i) an evolving type, characterised by a progressive increase in the M-protein size and short time to progression to overt multiple myeloma (MM) and (ii) a non-evolving type, with a long-lasting, stable M-protein and longer time to progression. Comparative genomic hybridisation (CGH) analyses in both subtypes of SMM (seven evolving and eight non-evolving SMM) were performed. Evolving SMM showed cytogenetic changes consistent with those found in de novo symptomatic MM (1q gains, chromosome 13 deletions) while the non-evolving variant showed no 1q gains and deletions were uncommon.
authors.affiliation: Haematology Department, Institute of Haematology and Oncology, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Rosiñol
authors.forename: Ana
authors.initials: A
authors.lastname: Carrió
authors.forename: Joan
authors.initials: J
authors.lastname: Bladé
authors.forename: Rosa
authors.initials: R
authors.lastname: Queralt
authors.forename: Marta
authors.initials: M
authors.lastname: Aymerich
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Cibeira
authors.forename: Jordi
authors.initials: J
authors.lastname: Esteve
authors.forename: Maria
authors.initials: M
authors.lastname: Rozman
authors.forename: Elías
authors.initials: E
authors.lastname: Campo
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
mesh_terms: D001856:Bone Marrow Examination; D002869:Chromosome Aberrations; D002882:Chromosomes, Human, Pair 13; D018450:Disease Progression; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase; D009101:Multiple Myeloma / Q000145:classification* / Q000235:genetics; D009194:Myeloma Proteins / Q000235:genetics*; D011379:Prognosis
chemical_list: D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins