title: Moderate effect of enamel matrix derivative (Emdogain Gel) on Porphyromonas gingivalis growth in vitro.
abstract: OBJECTIVE
  The aim of this study was to analyse the antibacterial effects of Emdogain Gel or its constituents on the growth of the suspected periodontopathogen Porphyromonas gingivalis.
  
  
  METHODS
  The effects of the proteins of enamel matrix derivative (EMD), the commercial product Emdogain Gel or its vehicle propylene glycol alginate (PGA) (Straumann, Switzerland) on P. gingivalis growth were determined by two methods: broth dilution assay (BDA) and agar diffusion assay (ADA).
  
  
  RESULTS
  BDA-Emdogain Gel inhibited moderately the growth of P. gingivalis, whereas EMD showed no effect. The PGA vehicle inhibited the growth completely. ADA-Emdogain Gel resulted in some inhibition in growth but was not significantly different from control. EMD revealed no zone of inhibition. PGA demonstrated statistically significant zones of inhibition.
  
  
  CONCLUSIONS
  Emdogain Gel shows moderate antibacterial activities against P. gingivalis. These properties seem to be due to the PGA component of the gel preparation.
authors.affiliation: Department of Periodontology, Charité, University Medicine, Augustenburger Platz 1, 13353 Berlin, Germany. clemens.walter@unibas.ch
authors.forename: Clemens
authors.initials: C
authors.lastname: Walter
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Jawor
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bernimoulin
authors.forename: Stefan
authors.initials: S
authors.lastname: Hägewald
mesh_terms: D000464:Alginates / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial / Q000379:methods; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007164:Immunosorbents / Q000494:pharmacology; D016966:Porphyromonas gingivalis / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D003746:Dental Enamel Proteins; D007164:Immunosorbents; C109069:enamel matrix proteins; C038550:propylene glycol alginate ester