[Pharmacological strategies in prevention of vascular injury].
Atherosclerosis is the most prevalent disease in the industrialized world and is an important cause of morbidity-mortality. This revision analyzes the most important studies regarding prevention and treatment of this entity, whose pathophysiological base is found in injury in the endothelial wall. The present trend is aimed at combined and intensive action on the cardiovascular risk factors, giving special attention to the diabetic patients. Increasingly lower thresholds are being established for the early onset of medical and pharmacological control. In this sense, early use of a single tablet with various components (statins, aspirin, folic acid, diuretics, ACEI and beta blockers) capable of acting simultaneously on the principal factors is advised. However, more well designed prospective studies are needed to be able to conclude on action.
Fernández Jiménez
P
P
Servicio de Medicina Interna, Hospital General Universitario de Albacete, Spain. mpilarfj@sescam.jccm.es
Solera Santos
J
J
D018663:Adrenergic Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control*; D015995:Prevalence
D018663:Adrenergic Agents; D002121:Calcium Channel Blockers