Pharmacological study of BRS, a new bicarbonated Ringer's solution, in partially hepatectomized rabbits.
OBJECTIVE
The effects of bicarbonated Ringer's solution were evaluated and compared with those of acetated Ringer's, lactated Ringer's and Ringer's solutions in partially hepatectomized rabbits.


METHODS
Animals were randomly divided into six groups (n = 6 in each group): a sham-operated group, an operated group without infusion, and four operated groups with infusions of each of the four Ringer's solutions. Each Ringer's solution was intravenously administered at 40 mL kg(-1) h(-1) for 1.5 h. Arterial blood gases, plasma magnesium concentrations and cardiovascular parameters were analysed.


RESULTS
The partial hepatectomy-induced decrement of base excess was inhibited by bicarbonated Ringer's solution more remarkably than by either lactated or plain solutions (P < 0.01). The alkalinizing effect of bicarbonated Ringer's solution tended to be more marked than that of the acetated solution but not significantly so. Plasma magnesium concentrations were well maintained by bicarbonated solution as compared to the other solutions (P < 0.01).


CONCLUSIONS
These results suggest that bicarbonated Ringer's solution is the most suitable perioperative solution for metabolic acidosis and plasma electrolyte balance among the Ringer's solutions tested.
Satoh
K
K
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan. kazunori_satou@ajinomoto.com
Ohtawa
M
M
Okamura
E
E
Satoh
T
T
Matsuura
A
A
D000138:Acidosis / Q000188:drug therapy*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006498:Hepatectomy; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D008274:Magnesium / Q000097:blood; D008297:Male; D011817:Rabbits; D000077331:Ringer's Solution; D014882:Water-Electrolyte Balance / Q000187:drug effects
D007552:Isotonic Solutions; D000077331:Ringer's Solution; D008274:Magnesium