title: Benzopyran, biphenyl, and tetraoxygenated xanthone derivatives from the twigs of Garcinia nigrolineata.
abstract: One new benzopyran, nigrolineabenzopyran A (1), two new biphenyls, nigrolineabiphenyls A and B (2, 3), and four new tetraoxygenated xanthones, nigrolineaxanthones T-W (4-7), were isolated from the crude methanol extract of the twigs of Garcinia nigrolineata along with 11 known xanthones. The xanthones isolated from the twigs as well as those from the stem bark were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus. Nigrolineaxanthone F, latisxanthone D, and brasilixanthone showed significant activity, with an equal MIC value of 2 microg/mL.
authors.affiliation: Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand. vatcharin.r@psu.ac.th
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Kwanruthai
authors.initials: K
authors.lastname: Tadpetch
authors.forename: Anyarat
authors.initials: A
authors.lastname: Watthanaphanit
authors.forename: Neangnoi
authors.initials: N
authors.lastname: Saengsanae
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013785:Thailand; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D001713:Biphenyl Compounds; D044004:Xanthones; C504384:nigrolineabenzopyran A; C504385:nigrolineabiphenyl A; C504386:nigrolineabiphenyl B