Molecular pathology of ovarian cancer.
Ovarian cancer is the leading cause of death among women with gynecologic malignancies. Epithelial tumors typically constitute 80-90% of ovarian malignancies and are classified primarily as serous, mucinous, endometrioid or clear cell. Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations. We describe such genetic alterations with specific reference to histologic subtypes.
Sanseverino
Francesca
F
Department of Gynecology and Obstetrics, University of Siena, Nuovo Policlinico Le Scotte, Siena, Italy.
D'Andrilli
Giuseppina
G
Petraglia
Felice
F
Giordano
Antonio
A
D018262:Adenocarcinoma, Clear Cell / Q000235:genetics / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology; D000232:Adenofibroma / Q000235:genetics / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000235:genetics / Q000473:pathology; D018291:Cystadenoma, Mucinous / Q000235:genetics / Q000473:pathology; D018293:Cystadenoma, Serous / Q000235:genetics / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D016163:Genes, DCC / Q000235:genetics; D018734:Genes, erbB-2 / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D009154:Mutation; D009375:Neoplasms, Glandular and Epithelial / Q000145:classification / Q000235:genetics / Q000473:pathology; D010051:Ovarian Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D011506:Proteins / Q000235:genetics; D050717:Retinoblastoma-Like Protein p130; D015534:Trans-Activators / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D011506:Proteins; D050717:Retinoblastoma-Like Protein p130; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D051176:beta Catenin; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human