title: Emergence of species-specific transporters during evolution of the hemiascomycete phylum.
abstract: We have traced the evolution patterns of 2480 transmembrane transporters from five complete genome sequences spanning the entire Hemiascomycete phylum: Saccharomyces cerevisiae, Candida glabrata, Kluyveromyces lactis, Debaryomyces hansenii, and Yarrowia lipolytica. The use of nonambiguous functional and phylogenetic criteria derived from the TCDB classification system has allowed the identification within the Hemiascomycete phylum of 97 small phylogenetic transporter subfamilies comprising a total of 355 transporters submitted to four distinct evolution patterns named "ubiquitous," "species specific," "phylum gains and losses," or "homoplasic." This analysis identifies the transporters that contribute to the emergence of species during the evolution of the Hemiascomycete phylum and may aid in establishing novel phylogenetic criteria for species classification.
authors.affiliation: Unité de Génétique, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.
authors.forename: Benoît
authors.initials: B
authors.lastname: De Hertogh
authors.forename: Frédéric
authors.initials: F
authors.lastname: Hancy
authors.forename: André
authors.initials: A
authors.lastname: Goffeau
authors.forename: Philippe V
authors.initials: PV
authors.lastname: Baret
mesh_terms: D001203:Ascomycota / Q000235:genetics*; D002176:Candida albicans / Q000235:genetics / Q000378:metabolism; D041221:Candida glabrata; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D019143:Evolution, Molecular; D016681:Genome, Fungal; D007716:Kluyveromyces / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D005810:Multigene Family; D020543:Proteome; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity; D025062:Yarrowia / Q000235:genetics / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D020543:Proteome