title: [Drug-associated interstitial lung disease: a diagnostic challenge].
abstract: Drugs are frequently incriminated as the cause of interstitial pneumonia. There are two major mechanisms of drug-associated interstitial lung disease: direct toxicity and immunoallergic reaction. When a drug is suspected, the difficulty lies in obtaining proof. The chronology of the disease and its manifestations together with earlier evidence reported in the literature can lead to a tentative diagnosis of drug-associated interstitial pneumonia. Proof is obtained through surveillance during the disease course. In nearly all patients, therapeutic decisions must be taken on the basis of suspected drug involvement.
authors.affiliation: Service de Pneumologie, Hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris. charles.mayaud@tnn.aphp.fr
authors.forename: Charles
authors.initials: C
authors.lastname: Mayaud
authors.forename: Muriel
authors.initials: M
authors.lastname: Fartoukh
authors.forename: Antoine
authors.initials: A
authors.lastname: Parrot
authors.forename: Jacques
authors.initials: J
authors.lastname: Cadranel
authors.forename: Bernard
authors.initials: B
authors.lastname: Milleron
authors.forename: Georges
authors.initials: G
authors.lastname: Akoun
mesh_terms: D018893:Bronchoalveolar Lavage; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*