[The effect of cyclooxygenase inhibitors on the bone and cartilage].
The experimental studies showed that cyclooxygenase inhibitors, decrease bone demineralization, prolong fracture healing and assimilation of bone grafts and implants. Due to chemical structure drugs inhibit, stimulate or do not significantly change cartilage matrix synthesis. In case of in-utero exposure non-selective drugs may induce skeletal developmental variations, which depends on the used dose and COX-1 inhibition potency.
Burdan
Franciszek
F
Zakładu Anatomii Prawidłowej Człowieka AM w Lublinie. fb3@wp.pl
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D002356:Cartilage / Q000187:drug effects*; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases