title: Prophylaxis against bone loss in Kock reservoir patients with reduced glomerular filtration rate.
abstract: OBJECTIVE
  We investigated whether treatment with calcium carbonate and vitamin D3 can improve the bone mineral content of patients with ileal reservoirs for continent urinary diversion and a reduced glomerular filtration rate (GFR).
  
  
  METHODS
  Twenty-six patients with Kock reservoirs were included in the study. Bone mineralization was determined using dual-energy X-ray absorptiometry. Kidney function was estimated from Cr-EDTA clearance and serum cystatin C concentration. Osteocalcin and parathyroid hormone in serum were also measured. Patients with reduced GFR were treated with calcium carbonate and vitamin D3 perorally.
  
  
  RESULTS
  Bone mineral density in the femur neck and hip increased in the treatment group, as reflected by an improved T score.
  
  
  CONCLUSIONS
  Patients with ileal reservoirs for continent urinary diversion and reduced kidney function should be supplemented with calcium carbonate and vitamin D3 in order to reduce the long-term risk of osteoporosis.
authors.affiliation: Department of Urology, Sahlgrenska University Hospital, Göteborg, Sweden. olof.jonsson@vgregion.se
authors.forename: Olof
authors.initials: O
authors.lastname: Jonsson
authors.forename: Hans
authors.initials: H
authors.lastname: Herlitz
authors.forename: Elisabet
authors.initials: E
authors.lastname: Lindholm
authors.forename: Göran
authors.initials: G
authors.lastname: Lindstedt
authors.forename: David
authors.initials: D
authors.lastname: Pazooki
authors.forename: Harriet
authors.initials: H
authors.lastname: Törnqvist
authors.forename: Dan
authors.initials: D
authors.lastname: Mellström
mesh_terms: D015519:Bone Density; D002118:Calcium / Q000627:therapeutic use*; D002762:Cholecalciferol / Q000627:therapeutic use*; D039021:Colonic Pouches; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D019587:Dietary Supplements; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000517:prevention & control*; D016476:Urinary Reservoirs, Continent
chemical_list: C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D002762:Cholecalciferol; D002118:Calcium