title: A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae).
abstract: A new flavone named miliufavol [8-(2-hydroxybenzyl)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one or 8-C-(o)-hydroxybenzylpachypodol] from Miliusa balansae (Annonaceae) was isolated and structurally elucidated by spectroscopic means besides four known flavones: ombuine, chrysosplenol B, pachypodol and chrysosplenol C. These flavonoids exhibited interesting cytotoxic activity against three human cell lines (KB, Hep-G2, RD) with IC50 values < 5 microg/ml.
authors.affiliation: Institute of Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet road, Cau Giay district, Ha Noi, Viet Nam.
authors.forename: D T
authors.initials: DT
authors.lastname: Huong
authors.forename: D V
authors.initials: DV
authors.lastname: Luong
authors.forename: T T P
authors.initials: TT
authors.lastname: Thao
authors.forename: T V
authors.initials: TV
authors.lastname: Sung
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004797:Enzyme-Linked Immunosorbent Assay; D047309:Flavones / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; C503790:miliufavol