Horizontally acquired genes for purine salvage in Borrelia spp. causing relapsing fever.
Unlike Borrelia burgdorferi, the relapsing fever agent Borrelia hermsii and the related Borrelia miyamotoi had purA and purB genes of the purine salvage pathway. These were located among the rRNA genes. Phylogenetic analysis indicated that these genes had a different evolutionary history than those of orthologs in other spirochetes.
Barbour
Alan G
AG
Pacific-Southwest Center, 346 Hewitt Hall, University of California Irvine, Irvine, CA 92697-4025, USA. abarbour@uci.edu
Putteet-Driver
Adrienne D
AD
Bunikis
Jonas
J
D000264:Adenylosuccinate Lyase / Q000235:genetics / Q000378:metabolism; D000265:Adenylosuccinate Synthase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001898:Borrelia / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D021901:DNA, Intergenic; D022761:Gene Transfer, Horizontal; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D011687:Purines / Q000378:metabolism*; D012061:Relapsing Fever / Q000378:metabolism* / Q000382:microbiology*
D021901:DNA, Intergenic; D011687:Purines; D007041:Hypoxanthine Phosphoribosyltransferase; D000264:Adenylosuccinate Lyase; D000265:Adenylosuccinate Synthase