Trifluoromethylation of flavonoids and anti-tumor activity of the trifluoromethylated flavonoid derivatives.
3-Trifluoromethylflavonoid derivatives were prepared for the first time by trifluoromethylation of 3-iodoflavonoid derivatives. Other C ring and B ring trifluoromethylated flavonoid derivatives were also prepared. All the compounds were tested for their effect on the U2OS cell cycle in vitro. Bistrifluoromethylated apigenin derivative 13 showed the strongest activity against the cell growth.
Wang
Cai-Ling
CL
Institute of Biological Sciences and Biotechnology, Donghua University, 1882 West Yanan Road, Shanghai 200051, China.
Li
Hong-Qi
HQ
Meng
Wei-Dong
WD
Qing
Feng-Ling
FL
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008745:Methylation
D000970:Antineoplastic Agents; D005419:Flavonoids