What parameters affect left ventricular diastolic flow propagation velocity? In vitro studies using color M-mode Doppler echocardiography.
BACKGROUND
Insufficient data describe the relationship of hemodynamic parameters to left ventricular (LV) diastolic flow propagation velocity (Vp) measured using color M-mode Doppler echocardiography.


METHODS
An in vitro LV model used to simulate LV diastolic inflow with Vp measured under conditions of varying: 1) Stroke volume, 2) heart rate (HR), 3) LV volume, 4) LV compliance, and 5) transmitral flow (TMF) waveforms (Type 1: constant low diastasis flow and Type 2: no diastasis flow).


RESULTS
Univariate analysis revealed excellent correlations of Vp with stroke volume (r = 0.98), LV compliance (r = 0.94), and HR with Type 1 TMF (r = 0.97). However, with Type 2 TMF, HR was not associated with Vp. LV volume was not related to Vp under low compliance, but inversely related to Vp under high compliance conditions (r = -0.56).


CONCLUSIONS
These in vitro findings may help elucidate the relationship of hemodynamic parameters to early diastolic LV filling.
Ogawa
Toshihiro
T
St. John Hospital & Medical Center, Detroit, MI, USA. julius.gardin@stjohn.org
Scotten
Lawrence N
LN
Walker
David K
DK
Yoganathan
Ajit P
AP
Bess
Renee L
RL
Nordstrom
Cheryl K
CK
Gardin
Julius M
JM
D001783:Blood Flow Velocity / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology; D003971:Diastole / Q000502:physiology*; D015150:Echocardiography, Doppler / Q000295:instrumentation / Q000379:methods*; D004548:Elasticity; D006339:Heart Rate; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*