Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.
The shikimate pathway for aromatic biosynthesis presents a target for antimalarial drug development as this pathway is absent from animals. This study extends previous work on inhibitors of the shikimate pathway, by examining their interaction with the antimalarial drugs pyrimethamine and atovaquone. Combinations of atovaquone with several shikimate analogues exhibited synergistic effects. These findings highlight potential use of shikimate pathway inhibitors in combination therapy.
McRobert
Louisa
L
School of Biology, University of Leeds, Leeds LS2 9JT, UK.
Jiang
Shende
S
Stead
Andrew
A
McConkey
Glenn A
GA
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D053626:Atovaquone; D004347:Drug Interactions; D009285:Naphthoquinones / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism; D002727:Proguanil; D011739:Pyrimethamine / Q000494:pharmacology*; D012765:Shikimic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology
D000962:Antimalarials; D009285:Naphthoquinones; D014227:Triazines; C026009:cycloguanil; D012765:Shikimic Acid; D002727:Proguanil; D053626:Atovaquone; D011739:Pyrimethamine