title: Hirsutide, a cyclic tetrapeptide from a spider-derived entomopathogenic fungus, Hirsutella sp.
abstract: The entomopathogenic fungus Hirsutella sp., isolated from an infected spider, was found to produce the new cyclotetrapeptide hirsutide (1), cyclo-(L-NMe-Phe-L-Phe-L-NMe-Phe-L-Val), along with the known cytochalasin Q (2), using a cytotoxicity-guided isolation procedure. The structure of 1 was elucidated using one- and two-dimensional NMR experiments, mass spectrometry, and Marfey's method for analyzing the configuration of the amino acids.
authors.affiliation: Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Lang
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Cummings
authors.forename: Anthony L J
authors.initials: AL
authors.lastname: Cole
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
mesh_terms: D000818:Animals; D005658:Fungi / Q000737:chemistry*; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D013112:Spiders; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; C504294:hirsutide