[Effect of soybean isoflavone on the cognitive function in ovariectomized mice].
OBJECTIVE
To explore the effect of soybean isoflavone on the cognitive function in ovariectomized mice and to study the cognitive function mechanism of soybean isoflavone.


METHODS
Forty-five Kunming female mice were randomly assigned into 5 groups: A (sham operated); B (ovariectomized, OVX); C (OVX + low dose soybean isoflavone); D (OVX + moderate dose soybean isoflavone); and E (OVX + high dose soybean isoflavone). The experiment lasted 60 days.


RESULTS
Ovariectomy significantly elongated the destination time of water maze, shortened the latent time of step-down test, decreased SOD of serum and Na+ K+ -ATPase and Ca2+ Mg2+ -ATPase of brain, and increased malonaldehyde of serum and monoamine oxidase of brain, which-could be inhibited by soybean isoflavone consumption.


CONCLUSIONS
The continuous oral administration of soybean isoflavone can improve the cognitive function of ovariectomized mice.
Zhu
Jian-Lin
JL
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China.
Yang
Gui-Lian
GL
Huang
Yi-Ming
YM
D000818:Animals; D003071:Cognition / Q000187:drug effects*; D005260:Female; D019833:Genistein / Q000302:isolation & purification / Q000494:pharmacology; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010052:Ovariectomy; D048789:Phytoestrogens / Q000302:isolation & purification / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry*
D007529:Isoflavones; D048789:Phytoestrogens; C004742:daidzein; D019833:Genistein