Effect of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm.
Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 63-year-old man with bleeding tendency and a large palpable abdominal aortic aneurysm (AAA) was diagnosed as having fibrinolysis dominant DIC by the excessive activation of both coagulation and fibrinolysis (plasmin -alpha2 plasmin inhibitor complex concentration is usually >4 microg/ml). Although several treatments were tried, DIC could not be controlled until the patient was given combined therapy of danaparoid (1,250 U/12 h, bolus IV) and tranexamic acid (0.5 g x 3/day, oral administration). This therapy may be beneficial when control for bleeding is required without restricting the ambulatory movement of patients by continuous drip.
Ontachi
Yasuo
Y
Department of Internal Medicine (III), Kanazawa University School of Medicine, Kanazawa, Japan. ontachiy@med3.m.kanazawa-u.ac.jp
Asakura
Hidesaku
H
Arahata
Masahisa
M
Kadohira
Yasuko
Y
Maekawa
Mio
M
Hayashi
Tomoe
T
Yamazaki
Masahide
M
Morishita
Eriko
E
Saito
Masanori
M
Minami
Shinji
S
Nakao
Shinji
S
D000925:Anticoagulants / Q000008:administration & dosage*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D003871:Dermatan Sulfate / Q000008:administration & dosage*; D004211:Disseminated Intravascular Coagulation / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D006497:Heparan Sulfate / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014148:Tranexamic Acid / Q000008:administration & dosage*
D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006497:Heparan Sulfate; D014148:Tranexamic Acid; C035838:danaparoid