Microbial transformation of curvularin.
The microbiological transformation of curvularin (1) with Beauveria bassiana ATCC 7159 afforded three new metabolites identified as curvularin-7-O-beta-D-glucopyranoside (2), curvularin-4'-O-methyl-7-O-beta-D-glucopyranoside (3), and 6-hydroxycurvularin-4'-O-methyl-6-O-beta-D-glucopyranoside (4) resulting from hydroxylation, glucosidation, and methylglucosidation of the substrate. Isolation of 6-methyl-2,4-dihydroxyphenyl-4'-O-methyl-1-O-beta-D-glucopyranoside (5) from the fermentation broth of B. bassiana ATCC 7159 without any added substrate suggested that hydroxylase, glucosyl transferase, and methylase are constitutive enzymes of this organism.
Zhan
Jixun
J
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706-6800, USA.
Gunatilaka
A A Leslie
AA
D001711:Biotransformation; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000201:enzymology* / Q000378:metabolism*; D005960:Glucosides / Q000737:chemistry / Q000378:metabolism*; D016695:Glycosyltransferases / Q000378:metabolism*; D008780:Methyltransferases / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D015394:Molecular Structure; D014407:Tumor Cells, Cultured; D015025:Zearalenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D005960:Glucosides; D015025:Zearalenone; D006899:Mixed Function Oxygenases; D008780:Methyltransferases; D016695:Glycosyltransferases; C013455:curvularin