title: Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats.
abstract: The carcinogenic potential of L-isoleucine, used as a food fortifier, was examined in both sexes of F344 rats. Groups of 50 female and 50 male animals were given diet containing L-isoleucine at concentrations of 0%, 2.5% or 5.0%. No treatment-related changes in the survival rate, general condition, body weight, food consumption, urinalysis, hematology or clinical chemistry data and organ weights were noted. Detailed histopathological examination revealed no treatment-related increase in the incidences of any non-neoplastic or neoplastic lesions. The results indicate that L-isoleucine is not carcinogenic in F344 rats of either sex.
authors.affiliation: DIMS Institute of Medical Science, Inc., 64 Goura, Nishiazai, Azai-cho, Ichinomiya 491-0113, Japan. kawabe@dims.co.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kawabe
authors.forename: Masashi
authors.initials: M
authors.lastname: Sano
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Seiko
authors.initials: S
authors.lastname: Tamano
authors.forename: Shugo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shirai
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D004032:Diet; D005260:Female; D007532:Isoleucine / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics
chemical_list: D002273:Carcinogens; D007532:Isoleucine