[The role of free radical processes and redox-signalization in adaptation of the organism to changes in oxygen level].
Data are presented on participation of free-radical oxygenation in development of the organism adaptation. The redox-signalization concept is discussed in the aspect of its responsibility for the initial stage of external signal transmission to the cell genetic apparatus. The pro- and antioxidant system ratio is noted as important for assessment of formation of the cell structure and the tissue resistance. A protective effect of periodic hyperoxia was shown as well as regularities of its development similar formation of adaptation to the periodic hyperoxia.
Sazontova
T G
TG
Arkhipenko
Iu V
IuV
D000222:Adaptation, Physiological; D000693:Anaerobiosis / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D014157:Transcription Factors