title: [Isoprenoid pigments in representatives of the family Microbacteriaceae].
abstract: By using fosmidomycin and mevinolin (inhibitors of the synthesis of isoprenoid pigments), spectrophotometry, and mass spectrometry, the presence of isoprenoid pigments is shown in 71 of the 78 strains under study. All of these strains belong to 11 genera of the family Microbacteriaceae. Yellow, orange, and red pigments are found to have absorption spectra typical of C40-carotenoids. Eight out of the sixteen strains of the genus Microbacterium are able to synthesize neurosporene, a precursor of lycopene and beta-carotene. The biosynthesis of carotenoids in some representatives of the genera Agromyces, Leifsonia, and Microbacterium is induced by light. Inhibition of the biosynthesis of isoprenoid pigments by fosmidomycin suggests that they are synthesized via the nonmevalonate pathway. Twelve strains are found to exhibit both the nonmevalonate and mevalonate pathways of isoprenoid synthesis. These data, together with the difference in the inhibitory concentration of fosmidomycin, can be used for differentiating various taxa within the family Microbacteriaceae.
authors.forename: S M
authors.initials: SM
authors.lastname: Trutko
authors.forename: L V
authors.initials: LV
authors.lastname: Dorofeeva
authors.forename: L I
authors.initials: LI
authors.lastname: Evtushenko
authors.forename: D N
authors.initials: DN
authors.lastname: Ostrovskiĭ
authors.forename: M
authors.initials: M
authors.lastname: Hintz
authors.forename: J
authors.initials: J
authors.lastname: Wiesner
authors.forename: H
authors.initials: H
authors.lastname: Jomaa
authors.forename: B P
authors.initials: BP
authors.lastname: Baskunov
authors.forename: V K
authors.initials: VK
authors.lastname: Akimenko
mesh_terms: D000192:Actinomycetales / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D005578:Fosfomycin / Q000031:analogs & derivatives / Q000494:pharmacology; D008148:Lovastatin / Q000494:pharmacology; D013058:Mass Spectrometry; D010860:Pigments, Biological / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D013053:Spectrophotometry; D013729:Terpenes / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D010860:Pigments, Biological; D013729:Terpenes; D005578:Fosfomycin; C024640:fosmidomycin; D008148:Lovastatin