Ruthenium-catalyzed arylation of 2-alkenylpyridines with aryl bromides: alternative E,Z-selectivity to Mizoroki-Heck reaction.
Regio- and stereoselective arylation of 2-alkenylpyridines with aryl bromides is catalyzed by specific Ru(II)-phosphine complexes affording beta-arylated (Z)-2-alkenylpyridines, in which the aryl moiety is introduced cis to the pyridyl group. This geometrical selectivity is in sharp contrast to the Mizoroki-Heck reaction. [reaction: see text]
Oi
Shuichi
S
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan. oishu@aporg.che.tohoku.ac.jp
Sakai
Kaori
K
Inoue
Yoshio
Y