title: Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis.
abstract: OBJECTIVE
  Adiponectin is a novel adipocytokine of extreme importance for the metabolism. Recent studies have indicated that adiponectin suppresses inflammation, angiogenesis, and fibrosis, which are central pathogenic factors for endometriosis. We addressed the possibility that adiponectin is implicated in endometriosis.
  
  
  METHODS
  We measured concentrations of adiponectin in peritoneal fluid (PF) of women with (n = 54) or without (n = 26) endometriosis using specific enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Adiponectin concentrations in PF of women with endometriosis were significantly lower than those of women without endometriosis. With respect to the stages of the disease, the concentrations of adiponectin in women with stage III/IV endometriosis were significantly lower compared to those in women without endometriosis and with stage I/II endometriosis. Body mass index were comparable among the groups.
  
  
  CONCLUSIONS
  These findings imply that adiponectin may be an anti-endometriotic factor, possibly due to its anti-inflammatory, anti-angiogenic, and anti-fibrotic properties.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Takemura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osuga
authors.forename: Miyuki
authors.initials: M
authors.lastname: Harada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hirata
authors.forename: Kaori
authors.initials: K
authors.lastname: Koga
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshino
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hirota
authors.forename: Chieko
authors.initials: C
authors.lastname: Morimoto
authors.forename: Tetsu
authors.initials: T
authors.lastname: Yano
authors.forename: Yuji
authors.initials: Y
authors.lastname: Taketani
mesh_terms: D052242:Adiponectin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D015992:Body Mass Index; D004715:Endometriosis / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism
chemical_list: D052242:Adiponectin