title: Effects of intratympanic injection of latanoprost in Meniere's disease: a randomized, placebo-controlled, double-blind, pilot study.
abstract: OBJECTIVE
  To determine the short-term effects of latanoprost, a selective FP prostanoid receptor agonist, in Meniere's disease.
  
  
  METHODS
  Latanoprost was administered by intratympanic injection once daily for 3 days. Before the first injection (day 1) and on days 5 and 15, hearing and tinnitus were determined. The patients assessed vertigo on a visual analogue scale on days 1-15. The study was randomized, double-blind, and placebo-controlled.
  
  
  RESULTS
  Latanoprost reduced vertigo/dysequilibrium around 30% (P < 0.05), and improved speech discrimination around 15% (P < 0.05). Tinnitus loudness deteriorated after injection of placebo (P < 0.01) but not after latanoprost. Side effects were few.
  
  
  CONCLUSIONS
  Latanoprost alleviated vertigo/dysequilibrium and improved hearing. The results indicate that the drug potentially could be useful for treatment of Meniere's disease.
authors.affiliation: Department of Otosurgery, University Hospital, Uppsala, Sweden. helge.rask-andersen@akademiska.se
authors.forename: Helge
authors.initials: H
authors.lastname: Rask-Andersen
authors.forename: Ulla
authors.initials: U
authors.lastname: Friberg
authors.forename: Marianne
authors.initials: M
authors.lastname: Johansson
authors.forename: Johan
authors.initials: J
authors.lastname: Stjernschantz
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006309:Hearing; D006801:Humans; D015552:Injections, Intralesional; D000077338:Latanoprost; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy*; D008875:Middle Aged; D010865:Pilot Projects; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000627:therapeutic use; D013067:Speech Perception; D016896:Treatment Outcome; D014432:Tympanic Membrane; D014717:Vertigo
chemical_list: D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost