title: Diffuse idiopathic neuroendocrine cell hyperplasia causing severe airway obstruction in a patient with a carcinoid tumor.
abstract: We report a 57-year-old female with severe airway obstruction who underwent resection of a tumor of unknown dignity during lung volume reduction surgery. The nodule consisted of a well-differentiated neuroendocrine tumor (carcinoid), and severe chronic obstructive lung disease was due to diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, a very rare cause of obliterative bronchiolitis. Radionuclide ablative therapy of the neuroendocrine tissue was considered but not found to be feasible due to a low lung/background ratio of the radiotracer.
authors.affiliation: Department of Pulmonary Medicine, Zurich University Hospital, Zurich, Switzerland.
authors.forename: Heiner
authors.initials: H
authors.lastname: Adams
authors.forename: Thomas
authors.initials: T
authors.lastname: Brack
authors.forename: Peter
authors.initials: P
authors.lastname: Kestenholz
authors.forename: Peter
authors.initials: P
authors.lastname: Vogt
authors.forename: Hans C
authors.initials: HC
authors.lastname: Steinert
authors.forename: Erich W
authors.initials: EW
authors.lastname: Russi
mesh_terms: D000402:Airway Obstruction / Q000209:etiology*; D001989:Bronchiolitis Obliterans / Q000209:etiology*; D002276:Carcinoid Tumor / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000473:pathology*; D020545:Respiratory Mucosa / Q000473:pathology