title: Prescription-event monitoring study on 13,164 patients prescribed risedronate in primary care in England.
abstract: Risedronate sodium is indicated in postmenopausal women for the prevention and treatment of osteoporosis and for the treatment of Paget's disease. Our aim was to evaluate the safety of risedronate in a large cohort of patients prescribed risedronate by general practitioners (GPs) in England, soon after it was marketed. An observational cohort study was conducted using the technique of prescription-event monitoring (PEM). Exposure data were obtained from dispensed National Health Service prescriptions issued between September 2000 and June 2002. Outcome data were collected by sending questionnaires to prescribing GPs requesting them to report any events that had occurred since starting risedronate, demographic details, indication, start and stop dates, reasons for stopping, suspected adverse drug reactions (ADRs) and causes of death. Event rates calculated as incidence densities (IDs) separately, for Paget's disease group and all other patients (osteoporosis group) were ranked and the difference between IDs in month 1 and months 2-6 calculated. The osteoporosis cohort comprised 13,180 patients (10,934 [83.0%] female); median ages for female and male patients were 73 and 69 years, respectively. The most frequently reported event in the first month of treatment was dyspepsia, being also amongst the most frequently reported reasons for stopping risedronate and suspected ADR. Adverse events assessed as possibly or probably related to risedronate included, six of facial edema and one each of Stevens-Johnson syndrome, swollen tongue, palpitation and episcleritis. Risedronate was fairly well tolerated. Adverse events affecting skin, eye, cardiovascular and immunological systems were identified. Prescribing doctors should be aware of these and monitor their patients accordingly.
authors.affiliation: Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK.
authors.forename: Beate Aurich
authors.initials: BA
authors.lastname: Barrera
authors.forename: Lynda
authors.initials: L
authors.lastname: Wilton
authors.forename: Scott
authors.initials: S
authors.lastname: Harris
authors.forename: Saad A W
authors.initials: SA
authors.lastname: Shakir
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001847:Bone Diseases / Q000453:epidemiology / Q000517:prevention & control*; D002423:Cause of Death; D015331:Cohort Studies; D004415:Dyspepsia / Q000139:chemically induced; D004739:England / Q000453:epidemiology; D012968:Etidronic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D005194:Family Practice; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D015994:Incidence; D008297:Male; D009325:Nausea / Q000139:chemically induced; D010001:Osteitis Deformans / Q000453:epidemiology / Q000517:prevention & control; D010024:Osteoporosis / Q000453:epidemiology / Q000517:prevention & control; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000517:prevention & control; D000068296:Risedronic Acid; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced
chemical_list: D050071:Bone Density Conservation Agents; D000068296:Risedronic Acid; D012968:Etidronic Acid