title: Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice.
abstract: Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.
authors.affiliation: FRE 2735 CNRS, IFRMP 23, UFR de Médecine and Pharmacie, Rouen Cedex1, France.
authors.forename: Malika
authors.initials: M
authors.lastname: El Yacoubi
authors.forename: Catherine
authors.initials: C
authors.lastname: Ledent
authors.forename: Marc
authors.initials: M
authors.lastname: Parmentier
authors.forename: Jean
authors.initials: J
authors.lastname: Costentin
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Vaugeois
mesh_terms: D058917:Adenosine A2 Receptor Antagonists; D000818:Animals; D001066:Appetite / Q000187:drug effects* / Q000502:physiology; D002110:Caffeine / Q000008:administration & dosage*; D004326:Drinking / Q000187:drug effects; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D043705:Receptor, Adenosine A2A / Q000235:genetics / Q000502:physiology*
chemical_list: D058917:Adenosine A2 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D002110:Caffeine