title: [Angiotensin converting enzyme gene polymorphism and type 2 diabetic retinopathy].
abstract: OBJECTIVE
  To prospectively clarify the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic retinopathy (DR) in Type 2 diabetic patients.
  
  
  METHODS
  A 6-year prospectively study was designed to investigate the change of retina of 72 Type 2 diabetic patients without retinopathy . All patients suffered from diabetes mellitus for more than 5 years and matched well in age, body mass index (BMI), mean arterial pressure (MAP), and fasting blood glucose (FBG). Patients were classified into 3 groups according to their genotypes of ACE. ACE gene I/D polymorphism was identified by polymerase chain reaction. The patients were followed up for 6 years and their BMI, serum creatinine (Scr), MAP, HbA1c, and retina were checked once every 1 - 2 years.
  
  
  RESULTS
  Seven subjects (9.7%) were discontinued prematurely. At the end of the study, there were no significant differences in the clinical parameters such as BMI, MAP, FBG, HbA1c, and Scr among the 3 groups (P > 0.05), and also in DR incidence in Type 2 diabetic patients among the 3 groups (II 67.9%, ID 69.6%, DD 64.3%, respectively, P > 0. 05).
  
  
  CONCLUSIONS
  There is no association between ACE gene I/D polymorphism and the genesis and development of DR in Type 2 diabetic patients.
authors.affiliation: Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China. lanliao_6@hotmail.com
authors.forename: Lan
authors.initials: L
authors.lastname: Liao
authors.forename: Min-Xiang
authors.initials: MX
authors.lastname: Lei
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Chen
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Guo
authors.forename: Xiu-Yun
authors.initials: XY
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D007703:Peptidyl-Dipeptidase A