Aging of human skeletal muscles.
Normal aging in humans is associated with progressive decrease in skeletal muscle mass and strength (sarcopenia) which contributes to frailty and falls. The age associated changes in body composition result from lower levels of anabolic hormones, oxidative damage, neuromuscular alterations and a general decrease in muscle protein turnover. In this review we discuss the potential mechanisms and physical activity as prevention and treatment of sarcopenia.
Nikolić
Marina
M
Department of Anatomy, Medical Faculty, University of Rijeka, Rijeka, Croatia. marina.nikolic@medri.hr
Bajek
Snjezana
S
Bobinac
Dragica
D
Vranić
Tamara Soić
TS
Jerković
Romana
R
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D016330:Frail Elderly; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009046:Motor Neurons; D018908:Muscle Weakness; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism*; D009133:Muscular Atrophy; D018384:Oxidative Stress; D014176:Protein Biosynthesis
D016207:Cytokines; D006133:Growth Substances