title: [Experimental study on anti-inflammatory effects of mahuang decoction and its compositions].
abstract: OBJECTIVE
  To explore the regularity of recipe composition by observing anti-inflammatory effects of Mahuang Decoction (MHD) and its compositions.
  
  
  METHODS
  Neutrophil aggregation was induced by intraperitoneal injection of glycogen in rats. Intraperitoneal lavage fluid (PLF) was collected and neutrophils were removed. Neutrophils were stimulated by calciumionophore A23187 in vitro to produce leukotriene B4. The concentration of leukotriene B4 was measured by reversed-phase HPLC, anti-inflammatory effect was observed by the auricular edema with dimethylbenze.
  
  
  RESULTS
  MHD and its compositions could inhibit the auricular edema with dimethylbenze and leukotriene production from neutrophils in rats. Inhibitory effects of MHD compositions were different.
  
  
  CONCLUSIONS
  MHD had significantly inhibitory effects on the auricular edema with dimethylbenze and leukotriene production from neutrophils in rats. The original formula (MHD) worked best. These result confirmed the rationality and scientific level of MHD.
authors.affiliation: Key Laboratory of Pharmaceutical of Materia Medica, Nanfang Medical University, Guangzhou.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiabo
authors.initials: J
authors.lastname: Luo
authors.forename: Feng
authors.initials: F
authors.lastname: He
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002449:Cell Aggregation; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007975:Leukotriene B4 / Q000378:metabolism*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010031:Otitis / Q000139:chemically induced; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014992:Xylenes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D014992:Xylenes; D007975:Leukotriene B4