Effects of Aralia continentalis on hyperalgesia with peripheral inflammation.
This study aimed to determine the antinociceptive effect of Aralia continentalis extract (AC) on Freund's adjuvant-induced arthritis in rats. Adult Sprague-Dawley rats received an injection of complete Freund's adjuvant (CFA) into the articular cavity of the ankle joint, and then antinociceptive behaviors and spinal Fos expression were examined. AC was found to suppress significantly nociceptive behaviors caused by CFA injection. In addition, it also decreased adjuvant-induced Fos expression in the lumbar spinal cord induced by CFA. In conclusion, this study showed that AC produced significant antinociceptive effects on CFA-induced arthritis in rats, and it is suggested that AC is recommended to alleviate the arthritis-related symptoms in humans.
Park
Hi-Joon
HJ
Research Group of Pain and Neuroscience, East-West Medical Research Institute, WHO Collaboration Center, Kyung Hee University, 1 Hoegidong, Dongdaemoongu, Seoul 130-701, South Korea.
Hong
Mi-Sook
MS
Lee
Ji Suk
JS
Leem
Kang-Hyun
KH
Kim
Chang-Ju
CJ
Kim
Jin-Woo
JW
Lim
Sabina
S
D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000843:Ankle Joint; D027983:Aralia; D005620:Freund's Adjuvant; D008297:Male; D010003:Osteoarthritis / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013131:Spine
D000700:Analgesics; D010936:Plant Extracts; D005620:Freund's Adjuvant