title: Correlation of serotypes and genotypes of macrolide-resistant Streptococcus agalactiae.
abstract: Despite the necessity for studies of group B streptococci (GBS), due to the increase in serious adult infections, the emergence of new serotypes, and the increased resistance to macrolide antibiotics, such studies have been limited in Korea. The primary purpose of the present study was to determine the frequency trends of GBS serotypes, including serotypes VI, VII, and VIII. The final objective was to elucidate the relationship between the genotypes and serotypes of macrolide-resistant GBS isolates from a Korean population. Among 446 isolates of Streptococcus agalactiae, isolated between January 1990 and December 2002 in Korea, the frequency of serotypes were III (36.5%), Ib (22.0%), V (21.1%), Ia (9.6%), VI (4.3%), II (1.8%), VIII (1.3%), IV (1.1%), and VII (0.9%). The resistance rates to erythromycin, by serotype, were 85% (V), 23% (III), 21% (VI), 3% (Ib), and 2% (Ia). Of 135 erythromycin- resistant S. agalactiae, ermB was detected in 105 isolates, mefA in 20 isolates, and ermTR in seven isolates; most type V isolates harbored the ermB gene, Ib type isolates had an equal distribution of resistance genes, type III isolates accounted for 70% of all isolates carrying mefA genes, and one fourth of type VI isolates had mefA genes.
authors.affiliation: Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, 162 Ilsan-dong, Wonju, Gangwon-do, Korea. u931018@wonju.yonsei.ac.kr
authors.forename: Young
authors.initials: Y
authors.lastname: Uh
authors.forename: Hyo Youl
authors.initials: HY
authors.lastname: Kim
authors.forename: In Ho
authors.initials: IH
authors.lastname: Jang
authors.forename: Gyu Yel
authors.initials: GY
authors.lastname: Hwang
authors.forename: Kap Jun
authors.initials: KJ
authors.lastname: Yoon
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D005838:Genotype; D012703:Serotyping; D013292:Streptococcus agalactiae / Q000145:classification* / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin