[Medical preservation of ovarian function before and during radiochemotherapy].
Intensive use of radiochemotherapy has greatly improved the prognosis associated with cancer in young women patients. However, improvement of the vital prognosis is frequently associated with impairment of fertility and premature ovarian failure. Cryopreservation of ovarian tissues has been developed but effective secondary use of cryopreserved tissue by means of autograft or through in vitro follicular maturation need yet to be clarified even though first success seemed to be recently obtained. Infant ovaries have been considered to be less sensitive than adult ovaries, which has suggested that hypophysal blockage could protect adult ovaries against fertility impairment before and during radiochemotherapy. Non-randomized studies using LHRH agonists support such a hypothesis. However what we know about physiopathology of follicular destruction involving exaggerated apoptosis and several animal models do not fit with these results. By consequence randomized studies need to be performed to verify the benefit, which one could expect from such a systematic clinical use.
Fénichel
P
P
Service d'endocrinologie et médecine de la reproduction, CECOS, CHU de Nice, BP 3079, 06202 Nice cedex 03, France. fenichel.p@chu-nice.fr
D000970:Antineoplastic Agents / Q000009:adverse effects*; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D010053:Ovary / Q000637:transplantation; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000517:prevention & control*; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents