Change in the ploidy of prostatic epitheliocyte nuclei during carcinogenesis.
Comparative computer-assisted microspectrophotometric analysis of histological preparations showed that the mean nuclear ploidy increased 1.3 times in glandular hyperplasia and 2-fold in adenocarcinoma of 3 progressive degrees of dysdifferentiation. Proliferative activity of cells also increased from stage to stage. The data visualize cell nuclei ploidy and facilitate objective differential diagnostic decision making.
Avtandilov
G G
GG
Russian Medical Academy of Postgradual Education, Moscow, Russia. avtand@e-mail.ru
Gundorova
L V
LV
D002467:Cell Nucleus / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D004847:Epithelial Cells / Q000648:ultrastructure; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D011003:Ploidies; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology / Q000648:ultrastructure*
D004273:DNA, Neoplasm