Platelet-mimicry of cancer cells: epiphenomenon with clinical significance.
Stem cell mimicry of cancer cells has been known for a long time and is considered to be responsible for ectopic gene expressions. The stem cell characteristics of tumor cells are shown to be involved in epithelial-mesenchymal transition and in the phenomenon of vascular mimicry. Certain cancer types acquire a geno-phenotype closely resembling the platelets and express several megakaryocytic genes (adhesion receptors alpha IIb beta 3, thrombin receptor and PECAM/CD 31 and/or platelet-type 12-LOX) able to activate the coagulation cascade or the platelets themselves. Here we define these potentials as platelet mimicry of cancer cells typical of pancreatic, breast, prostate, colorectal and urogenital cancers and melanoma. Data all support that platelet mimicry of certain cancer types is an important factor in their hematogenous dissemination and provides an attractive therapeutic target. Besides the long-available preclinical data, clinical trials have only recently provided evidence that targeting platelet mimicry of cancers is an efficient way to prevent tumor progression. The systematic discovery of the markers of platelet mimicry in various cancer types and their molecular targeting may provide new supportive therapeutic modalities for the management of the progressing disease.
Tímár
József
J
Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary. jtimar@oncol.hu
Tóvári
József
J
Rásó
Erzsébet
E
Mészáros
Livia
L
Bereczky
Bíborka
B
Lapis
Károly
K
D000818:Animals; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000209:etiology; D001792:Blood Platelets / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006801:Humans; D008533:Megakaryocytes / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D010641:Phenotype; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors