title: "Sweet silicones": biocatalytic reactions to form organosilicon carbohydrate macromers.
abstract: Immobilized lipase B from Candida antarctica (Novozyme 435) catalyzed the regioselective formation of ester bonds between organosilicon carboxylic diacids and a C1-O-alkylated sugar under mild reaction conditions (i.e., low temperature, neutral pH, solventless). Specifically, the acid-functionalized organosilicones reacted with the primary hydroxyl group at the C6 position of alpha,beta-ethyl glucoside during the regioselective esterification. The pure organosilicon-sugar conjugates were prepared in a one-step reaction without protection-deprotection steps and without activation of the acid groups with the integrity of the siloxane bonds. [reaction: see text]
authors.affiliation: NSF IUCRC for Biocatalysis and Bioprocessing of Macromolecules, Othmer Department of Chemical and Biological Sciences and Engineering, Polytechnic University, Six Metrotech Center, Brooklyn, NY 11201, USA.
authors.forename: Bishwabhusan
authors.initials: B
authors.lastname: Sahoo
authors.forename: Kurt F
authors.initials: KF
authors.lastname: Brandstadt
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Lane
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gross
mesh_terms: D002175:Candida / Q000201:enzymology*; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004800:Enzymes, Immobilized; D004951:Esterification; D005656:Fungal Proteins; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D012828:Silicones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates; D004800:Enzymes, Immobilized; D005656:Fungal Proteins; D012828:Silicones; C093667:Novozyme 435; D008049:Lipase