title: Cytotoxic diterpenoids from two lianas from the Suriname rainforest.
abstract: Bioassay-guided fractionation of the MeOH and EtOAc fractions of extracts of two lianas collected in Suriname has led to the isolation of five new diterpenoids, humirianthone 1, 1-hydroxy-humirianthone 2, 15R-humirianthol 3, patagonol 4, and patagonal 5, and the five known diterpenoids, humirianthol 7, annonalide 8, acrenol 9, icacinol 10, and the oxidized annonalide 11. All 10 diterpenoids showed cytotoxic activity against the A2780 human ovarian cancer cell line, and compounds 1, 3, 8, and 9 also showed activity against phytopathogenic fungi.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Eba
authors.initials: E
authors.lastname: Adou
authors.forename: Russell B
authors.initials: RB
authors.lastname: Williams
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Schilling
authors.forename: Stan
authors.initials: S
authors.lastname: Malone
authors.forename: Jan
authors.initials: J
authors.lastname: Meyer
authors.forename: Jan H
authors.initials: JH
authors.lastname: Wisse
authors.forename: Djon
authors.initials: D
authors.lastname: Frederik
authors.forename: Delon
authors.initials: D
authors.lastname: Koese
authors.forename: Marga C M
authors.initials: MC
authors.lastname: Werkhoven
authors.forename: Carl E
authors.initials: CE
authors.lastname: Snipes
authors.forename: Todd L
authors.initials: TL
authors.lastname: Werk
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity*; D005658:Fungi / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D011891:Rain; D013532:Suriname; D014197:Trees
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes