title: Optochemical sensor for an ornidazole assay using 1-amino-4-allyloxyanthraquinone as a fluorescent indicator.
abstract: To improve the stability of optochemical sensors (optodes), the fluorescence indicator 1-amino-4-allyloxyanthraquinone (AAA), which was synthesized by reacting allyl bromide with 1-amino-4-hydroxyanthraquinone, was covalently immobilized on surface-modified glass slides. The resulting sensor was used to determine the content of ornidazole based on fluorescence quenching. It showed a linear response toward ornidazole in the concentration range of 9.0 x 10(-6) to 1.0 x 10(-3) mol L(-1) with a detection limit of 8 x 10(-6) mol L(-1) at pH 7.5. This AAA-immobilized sensor has a rapid response, high stability and good selectivity to ornidazole.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Tan
authors.forename: Cheng-Gang
authors.initials: CG
authors.lastname: Niu
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Jiang
authors.forename: Guo-Li
authors.initials: GL
authors.lastname: Shen
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Yu
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009593:Nitroimidazoles / Q000737:chemistry*; D055095:Optics and Photonics / Q000295:instrumentation*; D009950:Ornidazole / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D005456:Fluorescent Dyes; D009593:Nitroimidazoles; D009950:Ornidazole