[Progress in study of ADAM33 gene].
A disintegin and metalloprotease-encoding gene (ADAM) 33, located on the short arm of chromosome 20 (20p13), was recently identified through a genome-wide scan for asthma. It is a new member of a family of genes encoding a group of the metalloproteinase superfamily called the ADAM family. The proteolytic activity of the ADAMs plays important role in the healthy and disease states. The identification of ADAM33 as a candidate gene for asthma may provide a newly therapeutic target for this disease.
Su
Zhi-Guang
ZG
Laboratory of Pulmonary Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. zhiguang_su@hotmail.com
Wen
Fu-Qiang
FQ
Feng
Yu-Lin
YL
D051722:ADAM Proteins / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D001249:Asthma / Q000235:genetics* / Q000378:metabolism; D016535:Bronchial Hyperreactivity / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide
D051722:ADAM Proteins; C450441:ADAM33 protein, human