Iontophoretic transdermal delivery of sumatriptan: effect of current density and ionic strength.
Iontophoretic transdermal delivery of sumatriptan was investigated in vitro. Among the conditions tested, 0.25 mA/cm2 and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus resulting in a transdermal flux of sumatriptan of 1273+/-83 nmol/cm2 h.
Femenía-Font
A
A
Departamento de Fisiología, Farmacología y Toxicología, Universidad Cardenal Herrera-CEU, 46113 Moncada, Spain.
Balaguer-Fernández
C
C
Merino
V
V
López-Castellano
A
A
D000279:Administration, Cutaneous; D000818:Animals; D002021:Buffers; D004423:Ear; D007478:Iontophoresis; D009994:Osmolar Concentration; D009995:Osmosis; D017366:Serotonin Receptor Agonists / Q000378:metabolism*; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D012869:Skin Absorption; D012965:Sodium Chloride / Q000737:chemistry; D018170:Sumatriptan / Q000737:chemistry / Q000378:metabolism*; D013552:Swine; D013997:Time Factors
D002021:Buffers; D017366:Serotonin Receptor Agonists; D012965:Sodium Chloride; D018170:Sumatriptan