title: Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: functional magnetic resonance imaging study.
abstract: A functional magnetic resonance imaging mental rotation paradigm was used to investigate the patterns of activation of fronto-parietal brain areas in male adolescents with attention-deficit hyperactivity disorder, combined type (ADHD-CT) compared with age-, gender-, handedness- and performance IQ-matched healthy controls. The ADHD-CT group had (a) decreased activation of the 'action-attentional' system (including Brodmann's areas (BA) 46, 39, 40) and the superior parietal (BA 7) and middle frontal (BA10) areas and (b) increased activation of the posterior midline attentional system. These different neuroactivation patterns indicate widespread frontal, striatal and parietal dysfunction in adolescents with ADHD-CT.
authors.affiliation: Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Silk
authors.forename: A
authors.initials: A
authors.lastname: Vance
authors.forename: N
authors.initials: N
authors.lastname: Rinehart
authors.forename: G
authors.initials: G
authors.lastname: Egan
authors.forename: M
authors.initials: M
authors.lastname: O'Boyle
authors.forename: J L
authors.initials: JL
authors.lastname: Bradshaw
authors.forename: R
authors.initials: R
authors.lastname: Cunnington
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D002648:Child; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D010296:Parietal Lobe / Q000503:physiopathology*