The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity.
BACKGROUND
An elevated plasma total homocysteine (tHcy) level has recently been established as an independent risk factor for thrombosis and vascular disease. However, the relationship between hyperhomocysteinemia and cardiovascular disease and obesity remains controversial. The aim of the study was to investigate a possible relationship between plasma tHcy levels and measures of childhood obesity.


METHODS
Forty children and adolescents with exogenous obesity and 20 non-obese subjects in an age-and sex-matched control group were investigated. Fasting samples were collected for plasma tHcy, serum insulin, leptin, vitamin B12, folate, creatinine and lipid parameters. Anthropometric characteristics and body compositions were assessed in both groups.


RESULTS
The obese patients had significantly higher tHcy levels than the non-obese controls (14.3+/-11.8 micromol/L vs 8.7+/-5.9 micromol/L; P=0.017). In both groups, plasma tHcy was positively related to serum leptin, but serum apolipoprotein B (apo B) levels were positively related to plasma tHcy levels only in obese patients.


CONCLUSIONS
Our study demonstrates for the first time that leptin and apo B are main correlates of tHcy in obese children and adolescents and suggests that hyperleptinemia and increased apo B may contribute to impairment of tHcy metabolism in childhood obesity.
Narin
Figen
F
Department of Biochemistry, Erciyes University Faculty of Medicine, 38039 Kayseri, Turkey nnarin@erciyes.edu.tr
Atabek
Mehmet Emre
ME
Karakukcu
Musa
M
Narin
Nazmi
N
Kurtoglu
Selim
S
Gumus
Hakan
H
Coksevim
Bekir
B
Erez
Rusen
R
D000293:Adolescent; D001055:Apolipoproteins B / Q000097:blood*; D049628:Body Size; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D012016:Reference Values; D012044:Regression Analysis; D014421:Turkey / Q000453:epidemiology
D001055:Apolipoproteins B; D007328:Insulin; D020738:Leptin; D006710:Homocysteine