title: Complement receptor 3 binds the Borrelia burgdorferi outer surface proteins OspA and OspB in an iC3b-independent manner.
abstract: Persistence of borreliae within the vertebrate host depends on the fate of interactions between the spirochetes and target cells. The present work demonstrates the direct binding of the Borrelia burgdorferi outer surface proteins OspA and OspB to CR3 and that this binding is independent of iC3b.
authors.affiliation: Leukocyte Biology Unit, I.C.G.E.B., Area Science Park, 34012 Trieste, Italy. garcia@icgeb.org
authors.forename: Rodolfo C
authors.initials: RC
authors.lastname: Garcia
authors.forename: Rossella
authors.initials: R
authors.lastname: Murgia
authors.forename: Marina
authors.initials: M
authors.lastname: Cinco
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism*; D000954:Antigens, Surface / Q000378:metabolism*; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001428:Bacterial Vaccines; D025065:Borrelia burgdorferi / Q000378:metabolism*; D016466:CHO Cells; D003179:Complement C3b / Q000378:metabolism / Q000502:physiology*; D006224:Cricetinae; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D008193:Lyme Disease / Q000378:metabolism; D016177:Macrophage-1 Antigen / Q000378:metabolism*; D011485:Protein Binding / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; D016177:Macrophage-1 Antigen; C072045:OspA protein; C077030:OspB protein, Borrelia burgdorferi; D003179:Complement C3b