Gatifloxacin as a possible cause of serious postoperative hypoglycemia.
The case we present describes an episode of serious postoperative hypoglycemia after cardiopulmonary bypass for a relatively minor cardiac procedure. A fluoroquinolone antibiotic had been administered, and we believe that this strongly contributed to this event. Fluoroquinolone antibiotics have a recognized propensity to alter glucose homeostasis.
Brogan
Shane E
SE
Department of Anesthesiology, University of Utah, Salt Lake City, Utah.
Cahalan
Michael K
MK
D000890:Anti-Infective Agents / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D003324:Coronary Artery Disease / Q000601:surgery; D005260:Female; D005402:Fistula / Q000601:surgery; D024841:Fluoroquinolones / Q000009:adverse effects*; D000077734:Gatifloxacin; D006345:Heart Septal Defects, Ventricular / Q000601:surgery; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*
D000890:Anti-Infective Agents; D001786:Blood Glucose; D024841:Fluoroquinolones; D000077734:Gatifloxacin