[Effects of the Panax notoginseng saponins on the level of synaptophysin protein in brain in rat model with lesion of Meynert].
OBJECTIVE
To observe the protective effect of Panax notoginseng saponins (PNS) on the level of synaptophysin ptotein in brain in rat model with Alzheimer's disease (AD).


METHODS
The AD rat models were established by intra-peritoneal injection of D-galactose combined with excitatory neurotoxin ibotenic acid injection into bilateral nbM. The activity and content of synaptophysin protein in brain were determined by immunohistochemistry analysis.


RESULTS
PNS could reduce the lesion of level of synaptophysin protein in brain, as compared with those of model group's rats.


CONCLUSIONS
PNS plays a protective role by reducing down of the level of synaptophysin protein in brain in lesion of AD animal model.
Zhong
Zhen-Guo
ZG
Istitute of Neurosciece Research, Gangxi Traditional Chinese Medical Nanning 530001, China. zhongzg@gxtcmu.edu.cn
Qu
Ze-Qiang
ZQ
Wang
Nai-Ping
NP
Zhang
Feng-Fen
FF
Zhang
Wen-Yan
WY
Lu
Uzhong-Peng
UP
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D020532:Basal Nucleus of Meynert / Q000187:drug effects / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005690:Galactose / Q000633:toxicity; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000633:toxicity; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D016708:Synaptophysin / Q000378:metabolism*
D036145:Ginsenosides; D018696:Neuroprotective Agents; D016708:Synaptophysin; D007051:Ibotenic Acid; D005690:Galactose