[New clinical staging system for carcinoma of nasal cavity].
OBJECTIVE
To establish a new staging system based on analysis of several presently used clinical staging systems for carcinoma of nasal cavity.


METHODS
The data of 122 patients treated from 1985 to 1997 in the cancer center of Sun Yat-sen University were analyzed, and a new clinical staging system was established using computer optimizing and screening combined with the clinical results. The survival analysis was performed by Kaplan-Meier estimates, and the multivariate analysis was achieved by Cox proportional hazard model.


RESULTS
The flaws in the presently used clinical staging systems proposed by Zhuang, Qiu, Department of Head and Neck of Cancer Center of Sun Yat-sen University and University of Florida and the AJCC'2002, were as follows: insufficient consideration of the modern tomography resulting in indefinite location of the tumor in clinical practice, the uneven distribution of patients in different stages, being unable to separate survival curves of different stages, and not containing of all necessary clinical staging information in some staging systems. However, based on our new staging system, the cases distributed in T1, T2, T3 and T4 was 16, 32, 42 and 32, and the 5-year survival rate was 78.8%, 64.6%, 49.9% and 30.0%, respectively. The cases distributed in stage I, II, III and IV was 16, 26, 45 and 35, and the 5-year survival rate was 78.8%, 68.4%, 51.3% and 29.0%, respectively. The overall 5-year survival rate was 61.6%.


CONCLUSIONS
Compared to the presently used clinical staging systems, the new staging system may have more advantages in various parameters for the clinical staging in the carcinoma of nasal cavity, and may be worth to be widely and clinical used.
Hu
Wei-han
WH
Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. huweihan@163.com
Zhao
Yan-li
YL
Fang
Sheng-hua
SH
Han
Fei
F
Kuang
Guo-ting
GT
Liu
Hui
H
Lu
Li-xia
LX
Yan
Jie
J
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009367:Neoplasm Staging / Q000592:standards*; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology*; D016016:Proportional Hazards Models; D012015:Reference Standards; D016019:Survival Analysis