[Lipoprotein(a) and plasminogen patients with diabetes mellitus complicated with peripheral angiopathy and hypertension].
High serum level of lipoprotein(a) [Lp(a)] is one of the risk factors of atherosclerosis and so do high total cholesterol (TC) or LDL-cholesterol (LDL-ch) serum levels or diabetes mellitus. Structure of the protein part of Lp(a) is similar to plasminogen (PL). The aim of the study was estimation serum concentrations of: Lp(a), TC, LDL-ch, HDL-cholesterol (HDL-ch), triglycerides (TG) and PL in diabetic patients macroangiopathy hypertension. 63 patients (35 females and 28 males) with diabetes mellitus were included into the study. 36 of them suffered from chronic limb ischaemia caused by diabetic macroangiopathy 44 persons of the group were hypertensive. Control group consisted of 15 healthy people in the similar age. PL was estimated by turbidimetric method, Lp(a)--by ELISA, other lipids--by routine methods.


RESULTS
In diabetic patients in comparison to healthy persons were significantly higher: Lp(a) serum (p<0.003), PL (p<0.001), TC, LDL-ch, and significantly lower: HDL-ch. There were no statistically significant differences in Lp(a), other lipids and PL levels in patients with chronic leg ischaemia vs without that complication and in hypertensive vs normotensive diabetics.
Sapian-Raczkowska
Bozena
B
Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii AM we Wrocławiu.
Adamiec
Rajmund
R
Zdrojowy
Krystyna
K
Masłowski
Leszek
L
D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003925:Diabetic Angiopathies / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood*; D010958:Plasminogen / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D017270:Lipoprotein(a); D014280:Triglycerides; D010958:Plasminogen