Inflammatory cytokines and acute graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation.
This study investigated the role of inflammatory cytokines in acute graft-versus-host disease (aGVHD) incidence and severity in 113 patients who underwent reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT). Among all tested cytokines in the first 3 months after allo-SCT, only interleukin-12 p70 (IL-12p70) levels in the first month were significantly associated with grades II to IV aGVHD development (P < .001). IL-12p70 levels were directly correlated with aGVHD severity grade (P < .001). Before aGVHD onset, blood monocytes, the main precursor pool of IL12p70-secreting dendritic cells, recovered more rapidly in patients with grades II to IV aGVHD (P = .005). Similarly, at the effector level, there was a more robust reconstitution of naive CD3+CD4+CD45RA+CD27+ T cells in patients developing grades II to IV aGVHD (P = .006). In multivariate analysis, IL-12p70 level measured in the first month was the strongest predictive factor for aGVHD development (P < .001). These findings, reconstituting a T(H)1 loop, support a model in which aGVHD reflects a type 1 alloreaction after RIC allo-SCT.
Mohty
Mohamad
M
Département d'Oncologie Médicale, Laboratoire d'Immunologie des Tumeurs, Unité de Transplantation et de Thérapie Cellulaire (UTTC), Marseille, France. mohtym@marseille.fnclcc.fr
Blaise
Didier
D
Faucher
Catherine
C
Vey
Norbert
N
Bouabdallah
Reda
R
Stoppa
Anne-Marie
AM
Viret
Frederic
F
Gravis
Gwenaelle
G
Olive
Daniel
D
Gaugler
Béatrice
B
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood* / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D016207:Cytokines