Indirect detection of DNA damage.
In this issue of Chemistry and Biology, Naegeli and coworkers show that the nucleotide excision repair system of mammalian cells detects bulky DNA adducts, not by recognition of the adduct per se, but by recognition of the undamaged partner strand in bulged form.
Maher
L James
LJ
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SWRochester, Minnesota 55905, USA. maher@mayo.edu
D018736:DNA Adducts / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism / Q000502:physiology; D009690:Nucleic Acid Conformation
D018736:DNA Adducts; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; C086984:XPC protein, human