Homocysteine and schizophrenia: from prenatal to adult life.
Homocysteine is becoming increasingly recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia. In this review, we first present background information supporting a role for homocysteine in schizophrenia. We then discuss our work on the role of hyperhomocystinemia during adulthood and risk of schizophrenia, and present preliminary evidence on a potential relationship between prenatal homocysteine and schizophrenia. Finally, we discuss the implications of these findings for future work on nutritional etiologies of schizophrenia.
Brown
Alan S
AS
College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA. asb11@columbia.edu
Susser
Ezra S
ES
D005260:Female; D006711:Homocystine / Q000378:metabolism*; D006801:Humans; D008297:Male; D010290:Parents; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012306:Risk; D012559:Schizophrenia / Q000378:metabolism*; D012565:Schizophrenic Psychology
D006711:Homocystine