title: Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons.
abstract: Human immunodeficiency virus (HIV)-infected patients respond poorly to hepatitis B vaccination. Records of 194 HIV-infected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P=.003).
authors.affiliation: Washington University School of Medicine, St. Louis, MO 63110, USA. toverton@im.wustl.edu
authors.forename: Edgar Turner
authors.initials: ET
authors.lastname: Overton
authors.forename: Somnuek
authors.initials: S
authors.lastname: Sungkanuparph
authors.forename: William G
authors.initials: WG
authors.lastname: Powderly
authors.forename: Warren
authors.initials: W
authors.lastname: Seyfried
authors.forename: Richard K
authors.initials: RK
authors.lastname: Groger
authors.forename: Judith A
authors.initials: JA
authors.lastname: Aberg
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D012367:RNA, Viral