title: An evaluation of the efficacy of methods used in screening for lower-limb arterial disease in diabetes.
abstract: OBJECTIVE
  Foot-related disease is the most common cause for hospital admission among the diabetic population. Lower-limb peripheral arterial occlusive disease (PAOD) is a major risk factor in diabetic foot disease. Screening for PAOD commonly includes foot pulses and the ankle-brachial pressure index (ABPI) and/or the toe-brachial pressure index (TBI), but concerns persist regarding their accuracy. We evaluated the efficacy of several commonly used screening methods in different subject populations.
  
  
  METHODS
  We studied 130 limbs in 68 individuals with no critical ischemia over 8 months. Limbs were grouped on the basis of the presence or absence of diabetes, clinically detectable peripheral neuropathy, and PAOD identified on color duplex imaging. Comparative analyses of foot pulses, the ABPI, the TBI, and distal Doppler waveform analysis were performed.
  
  
  RESULTS
  Foot pulses, the TBI, and qualitative waveform analyses were highly sensitive screening methods in individuals with and without diabetes. However, detectable peripheral neuropathy was associated with a reduced sensitivity and poor specificity of foot pulses, a reduction in sensitivity of the ABPI (71 to 38%), and a reduction in specificity of the TBI (81 to 61%) and qualitative waveform analysis (96 to 66%). Quantitative analysis failed to detect disease with severely damped and low-intensity signals.
  
  
  CONCLUSIONS
  Screening tools that are effective in screening for lower-limb PAOD in the nondiabetic population are less efficacious in diabetes, particularly in the presence of detectable peripheral neuropathy. Qualitative waveform analysis and the TBI were demonstrated to be more effective screening methods than the ABPI and foot pulses particularly in high-risk limbs with detectable peripheral neuropathy.
authors.affiliation: Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, UK. dwill1964@aol.com
authors.forename: Dean T
authors.initials: DT
authors.lastname: Williams
authors.forename: Keith G
authors.initials: KG
authors.lastname: Harding
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000453:epidemiology; D001916:Brachial Artery; D003920:Diabetes Mellitus / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000453:epidemiology; D003929:Diabetic Neuropathies / Q000503:physiopathology; D006801:Humans; D007866:Leg / Q000098:blood supply*; D011237:Predictive Value of Tests; D011312:Pressure; D012680:Sensitivity and Specificity; D014034:Toes / Q000098:blood supply