title: Effects of some kampo medicines on plasma levels of neuropeptide Y under venipuncture stress.
abstract: Some traditional Chinese herbal (Kampo) medicines have recently been evaluated for their clinical usefulness in stress and depression. These medicines have modulatory effects on the hypothalamic-pituitary-adrenal axis and sympathetic nervous system (SNS). We examined the effects of Rikkunshi-to, Hange-shashin-to, Hange-koboku-to, and Ninjin-to on plasma levels of neuropeptide Y (NPY), which is the representative neurotransmitter of the SNS, under venipuncture stress. Rikkunshi-to and Hange-shashin-to suppressed increases in plasma NPY-immunoreactive substance levels compared with the response to a placebo. In this study, Rikkunshi-to and Hange-shashin-to altered plasma levels of NPY under venipuncture stress. These effects might be beneficial in stress-related diseases and our results suggest that these medicines have clinical pharmacologic activity.
authors.affiliation: Department of Clinical Pharmacy, Oita University Hospital, Oita, Japan. SYUHKI@med.oita-u.ac.jp
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Sato
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Katagiri
authors.forename: Hiroki
authors.initials: H
authors.lastname: Itoh
authors.forename: Masaharu
authors.initials: M
authors.lastname: Takeyama
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004797:Enzyme-Linked Immunosorbent Assay; D005456:Fluorescent Dyes; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D020835:Medicine, Kampo; D009478:Neuropeptide Y / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D013315:Stress, Psychological / Q000378:metabolism*; D001616:beta-Galactosidase / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D009478:Neuropeptide Y; D001616:beta-Galactosidase