The use of steroid replacement therapy for the management of Addison's disease.
Addison's disease is an uncommon but potentially life-threatening condition characterized by adrenal failure. All patients require lifelong glucocorticoid replacement to maintain life and most also need aldosterone substitution. There has been some recent interest in the physiological role in humans of the adrenal androgen, dehydroepiandrosterone. This paper reviews optimal glucocorticoid and mineralo-corticoid replacement therapy and provides the available data on dehydroepiandrosterone replacement.
Elsheikh
M
M
Department of Endocrinology, Radcliffe Infirmary, Oxford, OX2 6HE, UK.
Wass
J A
JA