Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People.
BACKGROUND
Glucose intolerance may increase the risk of developing colorectal cancer.


METHODS
In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoalbumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer.


RESULTS
There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR]=2.39; 95% confidence interval [CI]; 0.89- 6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR=0.41; 95% CI, 0.14-1.04).


CONCLUSIONS
A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.
Ozasa
Kotaro
K
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Japan. kozasa@koto.kpu-m.ac.jp
Ito
Yoshinori
Y
Suzuki
Koji
K
Watanabe
Yoshiyuki
Y
Kojima
Masayo
M
Suzuki
Sadao
S
Tokudome
Shinkan
S
Tamakoshi
Koji
K
Toyoshima
Hideaki
H
Kawado
Miyuki
M
Hashimoto
Shuji
S
Hayakawa
Norihiko
N
Wakai
Kenji
K
Tamakoshi
Akiko
A
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000453:epidemiology*; D017127:Glycation End Products, Advanced; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012709:Serum Albumin / Q000032:analysis*; D012737:Sex Factors; D000093423:Glycated Serum Albumin
D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin