title: [Selective reporting of positive outcomes in randomised trials--secondary publication.. A comparison of protocols with published reports].
abstract: BACKGROUND
  Selective reporting of positive outcomes is associated with bias.
  
  
  METHODS
  We conducted a cohort study of 102 protocols of randomised trials approved by the Scientific Ethics Committees for Copenhagen and Frederiksberg in 1994-1995 and the corresponding 122 reports.
  
  
  RESULTS
  The median proportion of incompletely reported outcomes per trial was 50%. Statistically significant outcomes were more often fully reported, odds ratio 2.4. In 62% of trials, at least one primary outcome was changed.
  
  
  CONCLUSIONS
  Outcomes in randomised trials are often reported selectively.
authors.affiliation: H:S Rigshopitalet, Det Nordiske Cochrane Center, University Health Network Toronto, Department of Medicine. a.hrobjartsson@cochrane.dk
authors.forename: Asbjørn
authors.initials: A
authors.lastname: Hróbjartsson
authors.forename: An-Wen
authors.initials: AW
authors.lastname: Chan
authors.forename: Mette T
authors.initials: MT
authors.lastname: Haahr
authors.forename: Peter C
authors.initials: PC
authors.lastname: Gøtzsche
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Altman
mesh_terms: D002985:Clinical Protocols / Q000592:standards*; D015331:Cohort Studies; D003718:Denmark; D006801:Humans; D015201:Meta-Analysis as Topic; D017594:Publication Bias; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D016896:Treatment Outcome