title: High-field MR angiography on an in vitro stenosis model determination of the spatial resolution on 1.5 and 3T in correlation to flow velocity and contrast medium concentration.
abstract: Since the first description of coronary magnetic angiography (MRA) in the early of 1990, this method seems to be shaped us a promising noninvasive modality to view the coronary arteries. Since several years dedicated high-field MR systems up to 4T are available for human use. The aim of the study was the evaluation of an in vitro vessel model with defined stenoses on 1.5T and 3T. For imaging at 3T, we used a 3d gradient-echo-sequence (fast SPGR). Furthermore, we examined the influence of the flow velocity and the contrast medium concentration on the spatial resolution. The accurate detection of in vitro stenoses was possible in segments up to 0.6 mm at 3T, the best results were obtained at a flow velocity of 40 ml/min and a contrast medium concentration of 0.2 mmol/l. The influence of the contrast medium concentration was statistically not significant. These results show that the spatial resolution can be increased by the use of a high-field MR scanner. Further in vivo studies are necessary to eliminate the method's limitation in visualizing small distal vessel segments.
authors.affiliation: Department of Heart Surgery, University Hospital, Marburg, Germany. thomaswittlinger@t-online.de
authors.forename: T
authors.initials: T
authors.lastname: Wittlinger
authors.forename: I
authors.initials: I
authors.lastname: Martinovic
authors.forename: R
authors.initials: R
authors.lastname: Noeske
authors.forename: R
authors.initials: R
authors.lastname: Moosdorf
authors.forename: F
authors.initials: F
authors.lastname: Lehmann
mesh_terms: D001783:Blood Flow Velocity / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage*; D003326:Coronary Circulation / Q000187:drug effects; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D018810:Magnetic Resonance Angiography / Q000295:instrumentation / Q000379:methods; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
chemical_list: D003287:Contrast Media