title: Animal models for adult dermal wound healing.
abstract: Wound healing in adult mammals proceeds by a series of overlapping highly coordinated events. Dermal wound repair commences with the arrest of hemorrhage followed by an inflammatory response, re-epithelialization of the wound, and formation of granulation tissue within the wound space, culminating in the production of a scar. In order to study the processes involved in the repair of wounded tissue, we have developed a rodent model utilizing full thickness incisional and excisional dermal wounds, which allow for macroscopic observations and also provide tissue for the histological and immunocytochemical analysis of acute wounds and scarring.
authors.affiliation: School of Biological Sciences, University of Manchester, Manchester, UK.
authors.forename: Mary
authors.initials: M
authors.lastname: Birch
authors.forename: Annette
authors.initials: A
authors.lastname: Tomlinson
authors.forename: Mark W J
authors.initials: MW
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000096:biosynthesis; D002921:Cicatrix / Q000473:pathology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007249:Inflammation; D051379:Mice; D051381:Rats; D012867:Skin / Q000473:pathology*; D013552:Swine; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing
chemical_list: D018952:Antigens, CD34; D016212:Transforming Growth Factor beta