Calcium liberates PNAs from endosomes.
Many peptides are reported to enhance cellular uptake of peptide nucleic acids and other macromolecules. Cellular uptake, however, is not synonymous with cellular activity. In this issue of Chemistry and Biology, Nielsen and colleagues examine the traffic of PNAs and investigate protocols for improving recognition of target mRNA inside cells.
Corey
David R
DR
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA. corey@chop.swmed.edu
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000494:pharmacology*; D002478:Cells, Cultured; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D020135:Peptide Nucleic Acids / Q000493:pharmacokinetics*; D012333:RNA, Messenger / Q000378:metabolism
D020135:Peptide Nucleic Acids; D012333:RNA, Messenger; D002118:Calcium