[Coasting and ovarian stimulation protocols in high-responder patients undergoing assisted conception].
Over-responsive patients are at risk of ovarian hyperstimulation, which may lead to severe complications. The choice of ovarian stimulation protocol or the use of a coasting (gonadotrophins suspension) with its associated risk of too strong ovarian response will be discussed herein. As for in vitro fertilization stimulation protocols, the best are probably those which use steadily increasing low doses of gonadotrophins, associated to GnRH agonists (low-dose protocols) or those which complete a double hypophyseal inhibition (estro-progestative association and GnRH agonists). GnRH antagonists may also reduce the risk of ovarian hyperstimulation, by estradiol drop. Outside the context of in vitro fertilization GnRH continuous administration or low -dose gonadotrophin stimulation are the best options. A coasting will be performed when an excess follicle response is documented. Under strict hormonal follow-up and within four days it allows achieving a high rate of pregnancy with a lower risk of hyperstimulation. Compared to other therapies of hyperstimulation syndrome, the coasting allows to avoid cycle cancellation or freezing of all embryos.
Merviel
P
P
Centre d'assistance médicale à la procréation, CHU d'Amiens, 124, rue Camille-Desmoulins, 80054 Amiens cedex 01, France. merviel.philippe@chu-amiens.fr
Claeys
C
C
Héraud
M-H
MH
Lourdel
E
E
Lanta
S
S
Barbier
F
F
Nasreddine
A
A
D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006062:Gonadotropins / Q000008:administration & dosage; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000517:prevention & control; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D027724:Reproductive Techniques, Assisted
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol