title: [IFN-gamma in tear fluid in patients with cystic fibrosis].
abstract: OBJECTIVE
  To evaluate IFN-gamma concentration in tear fluid in CF patients.
  
  
  METHODS
  Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA.
  
  
  RESULTS
  The concentration of IFN-gamma in tear fluid in CF patients was 10.75+/-2.23 pg/ml, and 4.06+/-0.57 pg/ml in control group.
  
  
  CONCLUSIONS
  The results of this study indicate that increased concentration of IFN-gamma in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.
authors.affiliation: Z Kliniki Okulistyki Dzieciecej Akademii Medycznej w Białymstoku.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Mrugacz
authors.forename: Beata
authors.initials: B
authors.lastname: Zelazowska
authors.forename: Alina
authors.initials: A
authors.lastname: Bakunowicz-Lazarczyk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wysocka
authors.forename: Alina
authors.initials: A
authors.lastname: Minarowska
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D008297:Male; D013666:Tears / Q000737:chemistry*
chemical_list: D007371:Interferon-gamma