Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.
The effects of simvastatin treatment on Chlamydia pneumoniae lung infection, inflammation, and serum lipids in mouse model were studied. Simvastatin decreased viable chlamydial counts and increased inflammatory cell infiltrates in the lung tissue, suggesting that simvastatin treatment had both antichlamydial and immunomodulatory effects during an acute C. pneumoniae infection.
Erkkilä
Leena
L
National Public Health Institute, Department of Viral Diseases and Immunology, P.O. Box 310, 90101 Oulu, Finland. leena.erkkila@ktl.fi
Jauhiainen
Matti
M
Laitinen
Kirsi
K
Haasio
Kristiina
K
Tiirola
Terttu
T
Saikku
Pekka
P
Leinonen
Maija
M
D000818:Animals; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology; D016993:Chlamydophila pneumoniae; D004041:Dietary Fats; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008171:Lung Diseases / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D019821:Simvastatin / Q000627:therapeutic use*
D004041:Dietary Fats; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D019821:Simvastatin