Relation of C-reactive protein and one-year survival after acute myocardial infarction with versus without statin therapy.
We evaluated the interaction between inflammation and survival benefit from statin therapy in patients who had acute myocardial infarction. Although 1-year mortality did not differ between patients who used statin therapy and those who did not, among patients who had C-reactive protein (CRP) concentrations in the lower 2 tertiles (<2.9 mg/L), 1-year mortality was higher in patients who used statin therapy than in those who did not within the highest CRP-defined tertile (> or =2.9 mg/L). Statin therapy significantly decreased the hazard ratio for 1-year mortality in patients who had high CRP levels to approximately the hazard present for patients who had low CRP levels and did not receive statin therapy.
Kinjo
Kunihiro
K
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan.
Sato
Hiroshi
H
Sakata
Yasuhiko
Y
Nakatani
Daisaku
D
Mizuno
Hiroya
H
Shimizu
Masahiko
M
Nishino
Masami
M
Ito
Hiroshi
H
Tanouchi
Jun
J
Nanto
Shinsuke
S
Hori
Masatsugu
M
D002097:C-Reactive Protein / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000401:mortality*; D015996:Survival Rate / Q000639:trends
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein