Correlation between ceftriaxone resistance of Salmonella enterica serovar Typhimurium and expression of outer membrane proteins OmpW and Ail/OmpX-like protein, which are regulated by BaeR of a two-component system.
Mutant 7F2 of Salmonella enterica serovar Typhimurium has a transposon inserted in the regulator gene baeR of a two-component system and showed a more-than-fourfold reduction in resistance to ceftriaxone. Complementation analysis suggested an association among the outer membrane proteins OmpW and STM3031, ceftriaxone resistance, and baeR.
Hu
Wensi S
WS
Institute of Biotechnology in Medicine, School of Medical Technology and Engineering, National Yang-Ming University, 155, Li-Nong St., Sec. 2, Peitou, Taipei, Taiwan 112. huws@ym.edu.tw
Li
Pei-Chuan
PC
Cheng
Chao-Yin
CY
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002443:Ceftriaxone / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000494:pharmacology*; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004251:DNA Transposable Elements / Q000235:genetics; D005816:Genetic Complementation Test; D006801:Humans; D016296:Mutagenesis; D012486:Salmonella typhimurium / Q000187:drug effects*
D001425:Bacterial Outer Membrane Proteins; D002511:Cephalosporins; D004251:DNA Transposable Elements; D002443:Ceftriaxone