Animal models for adult dermal wound healing.
Wound healing in adult mammals proceeds by a series of overlapping highly coordinated events. Dermal wound repair commences with the arrest of hemorrhage followed by an inflammatory response, re-epithelialization of the wound, and formation of granulation tissue within the wound space, culminating in the production of a scar. In order to study the processes involved in the repair of wounded tissue, we have developed a rodent model utilizing full thickness incisional and excisional dermal wounds, which allow for macroscopic observations and also provide tissue for the histological and immunocytochemical analysis of acute wounds and scarring.
Birch
Mary
M
School of Biological Sciences, University of Manchester, Manchester, UK.
Tomlinson
Annette
A
Ferguson
Mark W J
MW
D000818:Animals; D018952:Antigens, CD34 / Q000096:biosynthesis; D002921:Cicatrix / Q000473:pathology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007249:Inflammation; D051379:Mice; D051381:Rats; D012867:Skin / Q000473:pathology*; D013552:Swine; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing
D018952:Antigens, CD34; D016212:Transforming Growth Factor beta