Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents.
A series of dihydropyrido[2,3-d]pyrimidines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 2a-2l have shown 83-100% inhibition against promastigotes and 79-100% inhibition against amastigotes at a concentration of 50 microg/mL.
Agarwal
Anu
A
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Ramesh
Ashutosh
Goyal
Neena
N
Chauhan
Prem M S
PM
Gupta
Suman
S
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D006859:Hydrogen / Q000737:chemistry; D007891:Leishmania / Q000187:drug effects*; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000981:Antiprotozoal Agents; D011743:Pyrimidines; D006859:Hydrogen