Metallacyclopeptides: artificial analogues of naturally occurring peptides.
Naturally occurring metalloproteins contain metal ions either to introduce a special reactivity or to stabilize a peptide structure. Since the early 1990s, chemists have been trying to use metal coordination for the fixation of short artificial peptides in well-defined cyclic structures. In this tutorial review a survey of the general approaches towards metallacyclopeptides as small cyclic peptide derivatives or as a part of a bigger alpha-helix (or beta-sheet) structure is given. In three case studies it is shown how naturally occurring compounds can be mimicked by metal coordination to non-natural peptide derivatives.
Albrecht
Markus
M
Institut für Organische Chemie, RWTH-Aachen, D-52074 Aachen, Germany. markus.albrecht@oc.rwth-aachen.de
Stortz
Patrick
P
D008667:Metalloproteins / Q000737:chemistry*; D008956:Models, Chemical; D018716:Molecular Mimicry; D010456:Peptides, Cyclic / Q000737:chemistry*; D017433:Protein Structure, Secondary
D008667:Metalloproteins; D010456:Peptides, Cyclic