[Polymorphism of N-acetyltransferase-2 and pathogenesis of neoplastic diseases].
Pathogenesis of many diseases is connected with influence of environmental factors with individual genetic sensitivity dependent among others on detoxification enzymes. Mutations of N-acetyltransferase-2 lead to decreased enzyme function. In this review the focus is on discussion about the connection between the polymorphic N-acetyltransferase-2 and increase in the risk of cancer, atopic disease and adverse drug effects.
Kłodowska-Duda
Gabriela A
GA
Z Kliniki Neurologii Wieku Podeszłego, Slaskiej Akademii Medycznej w Katowicach. neurowp@infomed.slam.katowice.pl
Samelska
Justyna A
JA
Opala
Grzegorz M
GM
D001191:Arylamine N-Acetyltransferase / Q000235:genetics* / Q000378:metabolism*; D004781:Environmental Exposure / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012307:Risk Factors
D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human