New plastoquinones isolated from the brown alga, Sargassum micracanthum.
Four new plastoquinones were isolated from the methanolic extract of the brown alga, Sargassum micracanthum. Their structures were elucidated based on spectroscopic analysis and chemical conversions from 2-geranylgeranyl-6-methyl-1,4-benzohydroquinone. These plastoquinones exhibited significant antioxidant activities such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). Some of the new plastoquiones showed cytotoxic activity against cancer cell line.
Mori
Jun
J
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University; 2630 Sugitani, Toyama 930-0194, Japan.
Iwashima
Makoto
M
Wakasugi
Hiroko
H
Saito
Haruo
H
Matsunaga
Takayuki
T
Ogasawara
Masaru
M
Takahashi
Satoshi
S
Suzuki
Hideyo
H
Hayashi
Toshimitsu
T
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002725:Chloroform; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D006834:Hydrazines / Q000737:chemistry; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D000432:Methanol; D051379:Mice; D009249:NADP / Q000737:chemistry; D010084:Oxidation-Reduction; D000459:Phaeophyceae / Q000737:chemistry*; D010851:Picrates; D011809:Quinones / Q000737:chemistry*; D051381:Rats; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D011809:Quinones; D012997:Solvents; D009249:NADP; D002725:Chloroform; C004931:1,1-diphenyl-2-picrylhydrazyl; D000432:Methanol