Comparative scintigraphic study of 99mTc ciprofloxacin pharmacokinetics after intravenous and lymphotropic administration in experimental pulmonary suppuration.
Intravenously injected 99mTc ciprofloxacin is rapidly accumulated and washed from the septic focus. Lymphotropic injections provide targeted and long-lasting effect of the antibiotic. After injection into the interspinous ligament the drug slowly enters the inflammation area (by-passing the urinary organs and liver), where it is maximally accumulated only after 24 h, which allows to reduce the number of injections and the total dose of the antibiotic.
Lishmanov
Yu B
YB
Institute of Cardiology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Sazonova
S I
SI
Sokolovich
E G
EG
Chernov
V I
VI
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008208:Lymphatic System / Q000378:metabolism; D061305:Lymphoscintigraphy; D008297:Male; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000378:metabolism*; D013492:Suppuration / Q000000981:diagnostic imaging / Q000378:metabolism; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D015609:Organotechnetium Compounds; C431804:Technetium Tc 99m ciprofloxacin; D002939:Ciprofloxacin