title: Long-term prognosis of patients with local recurrence after conservative surgery and radiotherapy for early breast cancer.
abstract: We have studied the long-term prognosis of 266 patients considered to have isolated local recurrence in the breast following conservative surgery and radiotherapy for early breast cancer. The median follow-up of the patients still alive after diagnosis of local relapse was 11.2 years. At 10 years from the date of salvage treatment, the overall survival rate for the 226 patients with invasive local recurrence was 39% (95% CI, 32-46), the distant recurrence-free survival rate was 36% (95% CI, 29-42), and the local control rate (i.e., survival without subsequent local recurrence or local progression) was 68% (95% CI, 62-75). Among patients with a local recurrence at or near the original tumour site a better distant disease-free survival was observed for patients with recurrences measuring 1cm or less, compared to those with larger recurrences. This suggests, though does not prove, that early detection of local recurrence can improve the treatment outcome but might as well point towards a different biologic behaviour, facilitating early detection.
authors.affiliation: Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. adri.voogd@epid.unimaas.nl
authors.forename: A C
authors.initials: AC
authors.lastname: Voogd
authors.forename: F J
authors.initials: FJ
authors.lastname: van Oost
authors.forename: E J T
authors.initials: EJ
authors.lastname: Rutgers
authors.forename: P H M
authors.initials: PH
authors.lastname: Elkhuizen
authors.forename: A N
authors.initials: AN
authors.lastname: van Geel
authors.forename: L J E E
authors.initials: LJ
authors.lastname: Scheijmans
authors.forename: M J C
authors.initials: MJ
authors.lastname: van der Sangen
authors.forename: G
authors.initials: G
authors.lastname: Botke
authors.forename: C J
authors.initials: CJ
authors.lastname: Hoekstra
authors.forename: J J
authors.initials: JJ
authors.lastname: Jobsen
authors.forename: C J H
authors.initials: CJ
authors.lastname: van de Velde
authors.forename: M F
authors.initials: MF
authors.lastname: von Meyenfeldt
authors.forename: J M
authors.initials: JM
authors.lastname: Tabak
authors.forename: J L
authors.initials: JL
authors.lastname: Peterse
authors.forename: M J
authors.initials: MJ
authors.lastname: van de Vijver
authors.forename: J W W
authors.initials: JW
authors.lastname: Coebergh
authors.forename: G
authors.initials: G
authors.lastname: van Tienhoven
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016462:Mammaplasty; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D011379:Prognosis; D012044:Regression Analysis; D016896:Treatment Outcome