title: Elevated plasma chemokine CCL18/PARC in beta-thalassemia.
abstract: Plasma CCL18/PARC, a member of the CC chemokine family, has been found to be several ten-fold increased in symptomatic Gaucher type I patients. Elevated plasma chitotriosidase levels are a well-known abnormality in Gaucher patients, however, its diagnostic use is limited by the frequent genetic deficiency in the protein. Like the situation in Gaucher disease, lipids accumulate in macrophages of patients suffering from beta-thalassemia, and, in both conditions, increased chitotriosidase levels occur. We here report that plasma CCL18/PARC is also significantly increased in patients with beta-thalassemia major (range 76.8-4977.8, median=650.8 ng/ml, n=36 and control range 10-72, median=33 ng/ml n=36 respectively, P<0.001). The CCL18/PARC levels are lower than in Gaucher patients (range 174.8-10798.7, median 2538.2 ng/ml, n=28, P<0.001). In our cohort of beta-thalassemic patients, CCL18/PARC showed a significant negative correlation to iron chelation therapy and a significant positive correlation to ferritin and chitotriosidase levels, the latter only in the patients with the wild type genotype for the enzyme. Our study demonstrates that beta-thalassemic patients have increased CCL18/PARC levels that could be of value in monitoring iron overload and compliance to therapy.
authors.affiliation: Department of Enzymology and Cellular Function, Institute of Child Health, "The Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Dimitriou
authors.forename: M
authors.initials: M
authors.lastname: Verhoek
authors.forename: S
authors.initials: S
authors.lastname: Altun
authors.forename: F
authors.initials: F
authors.lastname: Karabatsos
authors.forename: M
authors.initials: M
authors.lastname: Moraitou
authors.forename: J
authors.initials: J
authors.lastname: Youssef
authors.forename: R
authors.initials: R
authors.lastname: Boot
authors.forename: J
authors.initials: J
authors.lastname: Sarafidou
authors.forename: M
authors.initials: M
authors.lastname: Karagiorga
authors.forename: H
authors.initials: H
authors.lastname: Aerts
authors.forename: H
authors.initials: H
authors.lastname: Michelakakis
mesh_terms: D000293:Adolescent; D000328:Adult; D019742:Chemokines, CC / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005776:Gaucher Disease / Q000097:blood / Q000201:enzymology; D006115:Greece / Q000453:epidemiology; D006596:Hexosaminidases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D017086:beta-Thalassemia / Q000097:blood* / Q000201:enzymology
chemical_list: C111792:CCL18 protein, human; D019742:Chemokines, CC; D006596:Hexosaminidases; C086400:chitotriosidase