Induction of early meconium evacuation: is it effective in reducing the level of neonatal hyperbilirubinemia?
This prospective randomized trial evaluated the effect of induction of early meconium evacuation on neonatal jaundice in healthy term neonates. The study group was given glycerin suppository immediately after birth and every 4 hours thereafter, until evacuation of first stool. Glycerin suppository caused faster meconium evacuation but had no effect on mean bilirubin levels at 48 hours. However, males had significantly lower mean bilirubin levels, especially if they also had type A blood group. Glycerin suppository cannot be routinely recommended as a means for reducing the severity of neonatal jaundice. Nonetheless, male newborn with type A blood group may benefit from such a therapy.
Bader
David
D
Department of Neonatology, Bnai Zion Medical Center, The B. Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Yanir
Yoav
Y
Kugelman
Amir
A
Wilhelm-Kafil
Mira
M
Riskin
Arieh
A
D000017:ABO Blood-Group System; D001663:Bilirubin / Q000097:blood; D003672:Defecation / Q000187:drug effects; D005260:Female; D005990:Glycerol / Q000008:administration & dosage*; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000378:metabolism / Q000517:prevention & control*; D007231:Infant, Newborn; D008297:Male; D008470:Meconium / Q000378:metabolism*; D018579:Patient Selection; D011446:Prospective Studies; D012737:Sex Factors; D013488:Suppositories; D016896:Treatment Outcome
D000017:ABO Blood-Group System; D013488:Suppositories; D005990:Glycerol; D001663:Bilirubin