title: Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals.
abstract: We analyzed all the exons and exon-intron junctions of the CYP2D6 gene from 286 Japanese individuals. We detected two novel single nucleotide polymorphisms (SNPs) 2556C>T in exon 5 (Thr261Ile) and 3835A>C in exon 8 (Lys404Gln). Both these SNPs showed a frequency of 0.002.
authors.affiliation: Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University, Sendai, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Ebisawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiratsuka
authors.forename: Kanako
authors.initials: K
authors.lastname: Sakuyama
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Konno
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Sasaki
authors.forename: Michinao
authors.initials: M
authors.lastname: Mizugaki
mesh_terms: D044466:Asian People; D019389:Cytochrome P-450 CYP2D6 / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000302:isolation & purification; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D004247:DNA; D019389:Cytochrome P-450 CYP2D6