Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hepatic dysfunction.
The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (+/- SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 +/- 0.24 and 22.5 +/- 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-beta. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-alpha, and interferon-gamma than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.
Yeom
Joon-Sup
JS
Department of Internal Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Pyung-Dong 108, Jongro-Ku, Seoul 110-746, Republic of Korea.
Park
Se-Ho
SH
Ryu
Seung-Ho
SH
Park
Hae-Kyung
HK
Woo
So-Youn
SY
Ha
Eun-Hee
EH
Lee
Bo-Eun
BE
Yoo
Kwon
K
Lee
Joo-Ho
JH
Kim
Kwang-Ho
KH
Kim
Sunhil
S
Kim
Young-A
YA
Ahn
Sun-Young
SY
Oh
Sejoong
S
Park
Hyung-Joo
HJ
Min
Gi-Sik
GS
Seoh
Ju-Young
JY
Park
Jae-Won
JW
D000328:Adult; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007723:Korea; D008109:Liver Diseases, Parasitic / Q000097:blood*; D016780:Malaria, Vivax / Q000097:blood* / Q000150:complications; D008297:Male; D008889:Military Personnel; D012189:Retrospective Studies
D016207:Cytokines