title: [Influence of serum levels of luteinizing hormone during controlled ovarian hyperstimulation on the results of IVF cycle].
abstract: OBJECTIVE
  To evaluate the effect of endogenous luteinizing hormone level in the middle of in vitro fertilization cycle with depot GnRH agonist on the outcomes of assisted reproduction.
  
  
  METHODS
  Prospective clinical trial.
  
  
  METHODS
  2nd Department of Gynecology and Obstetrics of Medical Faculty and L. Pasteur University Hospital Kosice
  
  
  METHODS
  In the prospective clinical trial the effect of endogenous LH level during ovarian hyperstimulation with recombinant follicle stimulating hormone on outcomes of IVF was evaluated. The total number of 364 in vitro fertilization cycles in normogonadotrophic women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH controlled ovarian stimulation were included. A part of cycles with low residual LH levels were not included into statistical analysis, because of stimulation protocol adaptation. 315 cycles were taken into final statistical analysis. These cycles were divided into three groups according to middle stimulation LH level: under 0.5 IU/L, 0.5-2.0 IU/L and over 2.0 IU/L.
  
  
  RESULTS
  The best results were achieved in the middle group. The differences in most of parameters were statistically significant: FSH dosage, days of stimulation, number of oocytes, estradiol level, number of embryos and fertilization rate. Pregnancy rate and early pregnancy loss differences were not significant.
  
  
  CONCLUSIONS
  It was statistically evaluated that the best outcomes of assisted reproduction were in the group with LH level 0.5-2.0 IU/L. Correlation lines proved that the LH level 0.5 IU/L is the point under that the outcomes can worsen. It can be explained that the differences between pregnancy rates were not significant, because of low number of cycles with low residual LH levels included.
authors.affiliation: II. gynekologicko - porodnicka klinika LF UPJS a FN L. Pasteura, Kosice, Slovenská republika.
authors.forename: S
authors.initials: S
authors.lastname: Toporcerová
authors.forename: R
authors.initials: R
authors.lastname: Hredzák
authors.forename: A
authors.initials: A
authors.lastname: Ostró
authors.forename: V
authors.initials: V
authors.lastname: Zdilová
authors.forename: J
authors.initials: J
authors.lastname: Adam
authors.forename: D
authors.initials: D
authors.lastname: Potoceková
mesh_terms: D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008186:Luteolytic Agents / Q000008:administration & dosage; D010062:Ovulation Induction; D011247:Pregnancy; D011994:Recombinant Proteins / Q000008:administration & dosage; D017329:Triptorelin Pamoate / Q000008:administration & dosage
chemical_list: D043373:Follicle Stimulating Hormone, Human; D008186:Luteolytic Agents; D011994:Recombinant Proteins; D017329:Triptorelin Pamoate; D007986:Luteinizing Hormone