title: Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders.
authors.affiliation: Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. pesum@mail.nih.gov
authors.forename: Marko
authors.initials: M
authors.lastname: Pesu
authors.forename: John
authors.initials: J
authors.lastname: O'Shea
authors.forename: Lothar
authors.initials: L
authors.lastname: Hennighausen
authors.forename: Olli
authors.initials: O
authors.lastname: Silvennoinen
mesh_terms: D006801:Humans; D053614:Janus Kinase 2; D008958:Models, Molecular; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000503:physiopathology*; D017354:Point Mutation; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C507924:JAK2 protein, human; D053614:Janus Kinase 2