title: Nocturnal enuresis and allergy.
abstract: OBJECTIVE
  To investigate whether an interaction exists between nocturnal enuresis and allergy.
  
  
  METHODS
  Thirty-seven (20 boys, 17 girls) children with monosymptomatic nocturnal enuresis were recruited. We studied an allergy panel that included total IgE, 10 examples of inhalant-specific IgE, 10 examples of food-specific IgE, eosinophilic cationic protein (ECP) and Phadiotop. The same panel was studied in a control group of 18 children without monosymptomatic nocturnal enuresis.
  
  
  RESULTS
  We did not determine statistically significant differences between the enuretic group and the control group in terms of levels of total IgE, the 10 examples of inhalant-specific IgE and Phadiotop. However, two (soybean and hazelnut) of the 10 food-specific IgE and ECP levels did differ significantly between the two groups.
  
  
  CONCLUSIONS
  This first specific IgE study showed that there may be a relationship between nocturnal enuresis and soybean and hazelnut food allergens. Our findings may explain some cases of nocturnal enuresis. However, further studies are necessary to explain the underlying mechanisms and management of this disorder.
authors.affiliation: Department of Urology, Zonguldak Karaelmas University, Zonguldak, Turkey.
authors.forename: N Aydin
authors.initials: NA
authors.lastname: Mungan
authors.forename: Ilker
authors.initials: I
authors.lastname: Seckiner
authors.forename: Cetin
authors.initials: C
authors.lastname: Yesilli
authors.forename: Bulent
authors.initials: B
authors.lastname: Akduman
authors.forename: Ishak O
authors.initials: IO
authors.lastname: Tekin
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004775:Enuresis / Q000097:blood* / Q000150:complications*; D047150:Eosinophil Cationic Protein / Q000097:blood*; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D012130:Respiratory Hypersensitivity / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D000485:Allergens; D007073:Immunoglobulin E; D047150:Eosinophil Cationic Protein