Thiolate-bridged heterodinuclear platinum-zinc chelates as models for ternary platinum-DNA-protein complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-mass spectrometry.
Structures for model ternary platinum-DNA-protein complexes and zinc ejection from zinc fingers by platinum were deduced from the ESI-MS spectra of the interaction of model Zn and Pt complexes.
Liu
Qin
Q
Department of Chemistry, Virginia Commonwealth University, Richmond, VA, USA.
Golden
Melissa
M
Darensbourg
Marcetta Y
MY
Farrell
Nicholas
N
D000478:Alkylation; D002614:Chelating Agents / Q000737:chemistry*; D003432:Cross-Linking Reagents; D004247:DNA / Q000737:chemistry*; D007202:Indicators and Reagents; D008956:Models, Chemical; D010984:Platinum / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*; D016335:Zinc Fingers
D002614:Chelating Agents; D003432:Cross-Linking Reagents; D007202:Indicators and Reagents; D011506:Proteins; D013438:Sulfhydryl Compounds; D010984:Platinum; D004247:DNA; D015032:Zinc