title: Antimicrobial resistance of Helicobacter pylori in Poland: a multicentre study.
abstract: The resistance of Helicobacter pylori to antimicrobials, known to be increasing in many countries, is an important factor compromising the efficacy of eradication therapy. Therefore, our study aimed at analysing the current susceptibility status of H. pylori in Poland. A total of 337 H. pylori isolates were cultured from children (N=179) and adults (N=158) from various regions of the country from January 2001 to December 2004. All strains were susceptible to amoxicillin and tetracycline. The overall resistance to clarithromycin (CL) was 28%, but there were significant differences between the centres (ranging from 0% to 33%) and between child and adult isolates (28% versus 15%, respectively; P=0.01) for primary a resistance. Altogether, 46% of H. pylori isolates were resistant to metronidazole (MTZ) and 20% of isolates were simultaneously resistant to CL and MTZ.
authors.affiliation: Department of Clinical Microbiology and Immunology, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dzierzanowska-Fangrat
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Rozynek
authors.forename: Danuta
authors.initials: D
authors.lastname: Celińska-Cedro
authors.forename: Mirosław
authors.initials: M
authors.lastname: Jarosz
authors.forename: Jolanta
authors.initials: J
authors.lastname: Pawłowska
authors.forename: Aleksander
authors.initials: A
authors.lastname: Szadkowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Budzyńska
authors.forename: Jan
authors.initials: J
authors.lastname: Nowak
authors.forename: Wrzesław
authors.initials: W
authors.lastname: Romańczuk
authors.forename: Ryszard
authors.initials: R
authors.lastname: Prosiecki
authors.forename: Paulina
authors.initials: P
authors.lastname: Jóźwiak
authors.forename: Danuta
authors.initials: D
authors.lastname: Dzierzanowska
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D017291:Clarithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011044:Poland; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D013752:Tetracycline; D017291:Clarithromycin