Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs.
This article summarizes a roundtable discussion held at the 2005 Society of Toxicology Annual Meeting in New Orleans, LA. The purpose of the roundtable was to review the current challenges and data needs for conducting toxicological and safety evaluations for nanomaterials, with the goals of presenting the current state-of-the science on the safety of nanomaterials and bringing together scientists representing government, academia, and industry to identify priorities for developing data to facilitate risk assessments for these materials. In this summary, the unique physicochemical properties associated with nanomaterials are reviewed in the context of the difficulties associated with measuring and characterizing them. In addition, the development of appropriate hazard data, the collection of accurate human and environmental exposure information, and the development of a better fundamental understanding of the modes of action for nanomaterials are discussed as factors that will impact the development of comprehensive toxicological and safety evaluations.
Holsapple
Michael P
MP
ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005, USA.
Farland
William H
WH
Landry
Timothy D
TD
Monteiro-Riviere
Nancy A
NA
Carter
Janet M
JM
Walker
Nigel J
NJ
Thomas
Karluss V
KV
D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects* / Q000331:legislation & jurisprudence; D015386:Hazardous Substances / Q000145:classification / Q000633:toxicity*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry / Q000145:classification / Q000633:toxicity*; D036103:Nanotechnology; D018570:Risk Assessment / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods*
D015386:Hazardous Substances