Growth hormone releaser attenuates beta-amyloid (1 - 42)-induced memory impairment in mice.
Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Abeta) (1 - 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Abeta (1 - 42).
Shin
Eun-Joo
EJ
Neurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
Jhoo
Jin Hyeong
JH
Nabeshima
Toshitaka
T
Jhoo
Wang-Kee
WK
Kwon
Myung Sang
MS
Lim
Yong Kwang
YK
Chae
Jong Seok
JS
Jung
Myung Eun
ME
Park
Seok Joo
SJ
Jang
Kyung Jin
KJ
Kim
Hyoung-Chun
HC
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D001923:Brain Chemistry; D013006:Growth Hormone / Q000097:blood* / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000037:antagonists & inhibitors*; D013997:Time Factors
D000596:Amino Acids; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D013006:Growth Hormone; D000110:Acetylcholinesterase; D000109:Acetylcholine