The contemporary role of antioxidant therapy in attenuating liver ischemia-reperfusion injury: a review.
Oxidative stress is an important factor in many pathological conditions such as inflammation, cancer, ageing and organ response to ischemia-reperfusion. Humans have developed a complex antioxidant system to eliminate or attenuate oxidative stress. Liver ischemia-reperfusion injury occurs in a number of clinical settings, including liver surgery, transplantation, and hemorrhagic shock with subsequent fluid resuscitation, leading to significant morbidity and mortality. It is characterized by significant oxidative stress but accompanied with depletion of endogenous antioxidants. This review has 2 aims: firstly, to highlight the clinical significance of liver ischemia-reperfusion injury, the underlying mechanisms and the main pathways by which the antioxidants function, and secondly, to describe the new developments that are ongoing in antioxidant therapy and to present the experimental and clinical evidence about the role of antioxidants in modulating hepatic ischemia-reperfusion injury.
Glantzounis
Georgios K
GK
University Department of Surgery, Royal Free and University College Medical School, University College London, London, NW3 2PF, UK.
Salacinski
Henryk J
HJ
Yang
Wenxuan
W
Davidson
Brian R
BR
Seifalian
Alexander M
AM
D000975:Antioxidants / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply*; D008107:Liver Diseases / Q000188:drug therapy* / Q000503:physiopathology; D018384:Oxidative Stress; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology
D000975:Antioxidants