title: [Experimental study of using acellular dermal dermis instead of donor sclera in orbital implantation].
abstract: OBJECTIVE
  To evaluate the histocompatibility of homologous acellular dermal matrix as a wrapping material for a hydroxyapatite orbital implant and compare the speed of fibrovascular ingrowth in hydroxyapatite orbital implant wrapped with homologous acellular dermal matrix and homologous sclera respectively.
  
  
  METHODS
  Twenty four New Zealand rabbits were divided into two groups randomly. One group is implanted with hydroxyapatite orbital implant wrapped with homologous acellular dermal matrix behind the globe, the other group with homologous sclera. The observation included immunological reaction of the globe postoperation. Biopsies of implanted material were taken on weeks 1, 4, 8 and 12 postoperation for histopathological and electron microscope examination.
  
  
  RESULTS
  Histological examination showed the homologous acellular dermal matrix has no immunological and inflammatory reaction after implanted in orbit. But the speed of fibrovascular ingrowth is a little slower than that of homologous sclera.
  
  
  CONCLUSIONS
  The homologous acellular dermal matrix has the better histocompatibility as an encapsulating biomaterial, it can be a new material instead of homologous sclera.
authors.affiliation: Ophthalmology Department, Beijing Tongren Hospital, Capital Medicine University, Beijing 100730, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Min
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yu-liang
authors.initials: YL
authors.lastname: He
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D020405:Dermis / Q000637:transplantation*; D005260:Female; D008297:Male; D020273:Orbital Implants; D011817:Rabbits; D012590:Sclera / Q000637:transplantation*; D014184:Transplantation, Homologous
chemical_list: D001672:Biocompatible Materials