Cetirizine dihydrochloride interaction with some diclofenac complexes.
IR, 1H NMR and mass spectrometric studies showed that cetirizine dihydrochloride interacted strongly with diclofenac sodium, even when the latter was metal bound, forming high molecular weight stable adducts. These new formations were unaffected by the possible steric constraints that may exist because of coordination yet did not have the power to break the formed coordinate bonds. The formed ionic bond took place between the carbonyl ion of diclofenac and the positively charged piperazine ring of cetirizine, forming a ternary compound in the case of the divalent metal clusters (Ca{(dic)2.2H2O}, Mg{(dic)2.2H2O}, Zn{(dic)2.2H2O}) and a quaternary one with the trivalent iron cluster (Fe{dic}3.3H2O). IR bands assigned to nuNH, deltaNH and nuC-N were shifted to lower frequency values in the spectra of the complexes; thus showing that coordination took place at the NH of the diphenylamine. TG and elemental analysis confirmed these results.
Kenawi
Ihsan M
IM
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. ihsanata77@hotmail.com
Barsoum
Barsoum N
BN
Youssef
Maha A
MA
D017332:Cetirizine / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry*; D004347:Drug Interactions; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013817:Thermography
D008670:Metals; D004008:Diclofenac; D017332:Cetirizine