Diurnal dynamics of cell proliferation in rat liver during early postnatal ontogeny and effect of epidermal growth factor on hepatocyte proliferative activity.
Circadian rhythms of DNA synthesis, mitotic activity, and duration of mitosis in rat liver were studied on postnatal days 3, 7, and 12. Some age-related peculiarities of these rhythms were revealed. Epidermal growth factor was found to play an important role in the formation of cell proliferation rhythm during the early postnatal ontogeny and in the regulation of the pool of proliferating hepatocytes.
Smirnov
S N
SN
Lugansk State Medical University; Russian State Medical University, Moscow, Russia.
Zakharov
V B
VB
Mamontov
S G
SG
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D004261:DNA Replication / Q000187:drug effects / Q000502:physiology; D004815:Epidermal Growth Factor / Q000494:pharmacology / Q000502:physiology*; D022781:Hepatocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000166:cytology / Q000254:growth & development*; D008938:Mitosis / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004815:Epidermal Growth Factor