Covalent intermediates and enzyme proficiency.
Large enzyme efficiencies are due to small rate constants for the reaction in water, not to the formation of covalent intermediates.
Bruice
Thomas C
TC
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. tcbruice@chem.ucsb.edu
Bruice
Paula Yurkanis
PY
D000577:Amides / Q000737:chemistry; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry*; D004950:Esterases / Q000737:chemistry; D015394:Molecular Structure; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D000577:Amides; D004798:Enzymes; D014867:Water; D004950:Esterases