title: Toxicity of cadmium in Japanese quail: evaluation of body weight, hepatic and renal function, and cellular immune response.
abstract: Cadmium (Cd) is an environmental pollutant that is able to alter the immune function. Previous studies have shown that, in mammals, chronic exposure to Cd decreases the release of macrophagic cytokines such as IL1 and TN alpha and decreases phagocytosis activity. On the other hand contradictory results showed an increase in the humoral response. The cellular response could be decreased by exposure to Cd. These alterations were observed in mammals. The present study aimed to investigate some of the toxic effects of Cd exposure in birds. In particular, the main objective of this work was to elucidate the effects of exposure to this pollutant on the cellular immune function of the Japanese quail as a model for the study of toxicity in animals exposed in nature. The animals were exposed to the metal (100 ppm, per os) during development, i.e., from 1 to 28 days old. Body weight, biochemical parameters, and cellular immune response were measured during and at the end of treatment. The results showed that the exposure to Cd for 28 days significantly reduced the body weight and induced hepatic toxicity. The kidney function and cellular immune response were not affected by the Cd exposure.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, 05508-900 São Paulo, SP, Brazil.
authors.forename: M G
authors.initials: MG
authors.lastname: Sant'Ana
authors.forename: R
authors.initials: R
authors.lastname: Moraes
authors.forename: M M
authors.initials: MM
authors.lastname: Bernardi
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity*; D003370:Coturnix; D007111:Immunity, Cellular / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D015431:Weight Loss; D014921:Wings, Animal / Q000187:drug effects / Q000276:immunology
chemical_list: D010835:Phytohemagglutinins; D002104:Cadmium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin