title: Inducing peripheral sympathetic nerve activity by therapeutic electrical stimulation.
abstract: OBJECTIVE
  To examine whether the activity of peripheral sympathetic nerves in animals with spinal cord injury can be controlled using therapeutic electrical stimulation.
  
  
  METHODS
  The spinal cords of 6 Wistar rats were severed at T12/T13 disk level and were given continuous therapeutic electrical stimulation. Microneurography was used to record sympathetic nerve activity at 24, 48, and 72 hours after severing the spinal cord.
  
  
  RESULTS
  Integrated values of muscle sympathetic nerve activity after 72 hours of therapeutic electrical stimulation revealed significantly larger potentials on the stimulated side than the non-stimulated side. Skin sympathetic nerve activity showed no difference between the 2 sides.
  
  
  CONCLUSIONS
  Therapeutic electrical stimulation was found to have a facilitatory effect on the muscle sympathetic nerve activity, whereas regulatory function was activated by the sympathetic nerves.
authors.affiliation: Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Kira
authors.forename: S
authors.initials: S
authors.lastname: Aramaki
mesh_terms: D000818:Animals; D017776:Autonomic Pathways / Q000502:physiology; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005260:Female; D008297:Male; D017933:Peripheral Nervous System / Q000502:physiology; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013119:Spinal Cord Injuries / Q000628:therapy*; D013564:Sympathetic Nervous System / Q000502:physiology*