[Pulmonary alveolar phospholipoproteinosis].
Pulmonary alveolar phospholipoproteinosis is a rare lung disease of unknown cause characterized by surfactant plugging of the alveoli. At the present time, surgical lung biopsy, long considered as the gold standard, is not necessary for positive diagnosis of pulmonary alveolar phospholipoproteinosis when computed tomography anomalies and analysis of bronchial lavage fluids present a typical pattern. Treatment requires abundant lavage, but the demonstration of anti-GM-CSF antibodies in primary forms opens new therapeutic perspectives.
Delaval
Philippe
P
Service de Pneumologie, Centre Cardio-Pneumologique, Hôpital Pontchaillou, CHU, 35033 Rennes Cedex. philippe.delaval@chu-rennes.fr
Brinchault
Graziella
G
Corre
Romain
R
Jouneau
Stéphane
S
Meunier
Catherine
C
Briens
Eric
E
D000906:Antibodies / Q000627:therapeutic use; D018893:Bronchoalveolar Lavage; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy; D011663:Pulmonary Surfactants / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D000906:Antibodies; D008074:Lipoproteins; D010743:Phospholipids; D011663:Pulmonary Surfactants; D016178:Granulocyte-Macrophage Colony-Stimulating Factor