title: Intra-venous digital subtraction angiography: an alternative method to intra-arterial digital subtraction angiography for experimental aneurysm imaging.
abstract: Conventional intra-arterial digital subtraction angiography (IADSA), which necessitates surgical exposure and ligation of the femoral artery, is an invasive and expensive method of evaluation for experimental elastase-induced aneurysms in rabbits. The purpose of this study was to examine and validate intra-venous digital subtraction angiography (IVDSA) as an alternative to IADSA by comparing their diagnostic accuracies. We performed both IVDSA and IADSA for 24 elastase-induced saccular aneurysms in a rabbit model, 1 month following creation. Aneurysm sizes (neck, width and height) from both the IVDSA and IADSA procedures were evaluated and measured. Comparison of the aneurysm sizes between IVDSA and IADSA were performed with the Wilcoxon paired signed-rank test. All the aneurysms were seen clearly in both the IVDSA and IADSA techniques. Mean sizes of the IVDSA aneurysm neck, width and height were 3.41 +/- 0.80 mm, 3.61 +/- 0.93 mm and 8.07 +/- 2.11 mm, respectively. Mean sizes of the IADSA aneurysm neck, width and height were 3.43 +/- 0.80 mm, 3.66 +/- 0.92 mm and 8.16 +/- 2.25 mm, respectively. No significant difference was found in the sizes of the aneurysm neck, width and height between the two groups (P = 0.311, P = 0.086 and P = 0.258, respectively). IVDSA appears to be an alternative method for evaluating elastase-induced aneurysms in rabbits.
authors.affiliation: Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, MN 55905, USA.
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Ding
authors.forename: Daying
authors.initials: D
authors.lastname: Dai
authors.forename: Debra A
authors.initials: DA
authors.lastname: Lewis
authors.forename: Mark A
authors.initials: MA
authors.lastname: Danielson
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Kadirvel
authors.forename: Jayawant N
authors.initials: JN
authors.lastname: Mandrekar
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Cloft
authors.forename: David F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D015901:Angiography, Digital Subtraction / Q000379:methods*; D000818:Animals; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000473:pathology; D010196:Pancreatic Elastase; D011817:Rabbits; D018709:Statistics, Nonparametric; D014680:Veins
chemical_list: D010196:Pancreatic Elastase