Oxygenated terpenoids from a formosan soft coral Sinularia gibberosa.
Three new oxygenated sesquiterpenoids, gibberodione (1), peroxygibberol (2), and sinugibberodiol (3), along with sarcophytol L (4) were isolated from a Formosan soft coral, Sinularia gibberosa. The structures of the new metabolites were determined on the basis of extensive spectroscopic analyses and by comparison of NMR data with those of related metabolites. Metabolites 2 and 4 were found to exhibit moderate cytotoxicity toward a human liver carcinoma cell line.
Ahmed
Atallah F
AF
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
Kuo
Yao-Haur
YH
Dai
Chang-Feng
CF
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010100:Oxygen / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C504390:gibberodione; C504391:peroxygibberol; C504392:sinugibberodiol; D010100:Oxygen