title: Antiinflammatory and analgesic activities of the tissue culture of Saussurea involucrata.
abstract: The tissue culture of Saussurea involucrata (TCSauI) KAR. et KIR. was studied to determine its antiinflammatory and analgesic activities in experimental animals. Similar to wild S. involucrata, TCSauI at doses of 75-300 mg/kg i.g. for 7 d markedly inhibited hindpaw edema induced by carrageenin in rats, ear edema induced by dimethylbenzene, and increased capillary permeability in the mouse abdominal cavity induced by acetic acid. Moreover, TCSauI had inhibitory activities against the writhing reaction induced by acetic acid and the hot plate reaction in mice. The present study provided evidence first that TCSauI has antiinflammatory and analgesic activities, suggesting the potential of the tissue culture technique to substitute for wild S. involucrata in the pharmaceutical industry.
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.
authors.forename: Jing Ming
authors.initials: JM
authors.lastname: Jia
authors.forename: Chun Fu
authors.initials: CF
authors.lastname: Wu
authors.forename: Wen
authors.initials: W
authors.lastname: Liu
authors.forename: Hai
authors.initials: H
authors.lastname: Yu
authors.forename: Yue
authors.initials: Y
authors.lastname: Hao
authors.forename: Jian Hua
authors.initials: JH
authors.lastname: Zheng
authors.forename: Yu Rong
authors.initials: YR
authors.lastname: Ji
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D018515:Plant Leaves / Q000166:cytology; D018547:Plant Stems / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D030441:Saussurea / Q000737:chemistry*; D046509:Tissue Culture Techniques
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D019342:Acetic Acid