Synthesis of novel polyethers in a geometrically precise conformation.
[reaction: see text] A convergent design for the preparation of a polyoxyethylene-based channel molecule is presented, and the synthesis of the key unit 2 required for the projected construction is described. The essential elements of the design included face to face oriented macrorings spaced by rigid trans-fused oxanes. The strategy combines conformational predictability of C-linked oxanyl systems and ring-closing metathesis for the synthesis of crown ethers with engineerable ion-binding abilities.
Rodríguez
R M
RM
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio, s/n, Isla de la Cartuja, 41092 Seville, Spain.
Morales
E Q
EQ
Delgado
M
M
Espínola
C G
CG
Alvarez
E
E
Pérez
R
R
Martín
J D
JD