title: Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates.
abstract: Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: Jingbo
authors.initials: J
authors.lastname: Xiao
authors.forename: Jianfei
authors.initials: J
authors.lastname: Jiang
authors.forename: Natalia A
authors.initials: NA
authors.lastname: Belikova
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Tyurin
authors.forename: Mitchell P
authors.initials: MP
authors.lastname: Fink
authors.forename: Valerian E
authors.initials: VE
authors.lastname: Kagan
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006096:Gramicidin / Q000138:chemical synthesis / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D003497:Cyclic N-Oxides; D005609:Free Radicals; D010455:Peptides; D006096:Gramicidin; C003959:TEMPO