title: Role of toll-like receptor 4 in the proinflammatory response to Vibrio cholerae O1 El tor strains deficient in production of cholera toxin and accessory toxins.
abstract: Following intranasal inoculation, Vibrio cholerae KFV101 (DeltactxAB DeltahapA DeltahlyA DeltartxA) colonizes and stimulates tumor necrosis factor alpha and interleukin 1beta (IL-1beta) in mice, similar to what occurs with isogenic strain P4 (DeltactxAB), but is less virulent and stimulates reduced levels of IL-6, demonstrating a role for accessory toxins in pathogenesis. Morbidity is enhanced in C3H/HeJ mice, indicating that Toll-like receptor 4 is important for infection containment.
authors.affiliation: Northwestern University, Dept. of Microbiology-Immunology, 303 E. Chicago Avenue, Tarry 3-713, Chicago, IL 60611, USA.
authors.forename: G Kenneth
authors.initials: GK
authors.lastname: Haines
authors.forename: Blayne Amir
authors.initials: BA
authors.lastname: Sayed
authors.forename: Melissa S
authors.initials: MS
authors.lastname: Rohrer
authors.forename: Verena
authors.initials: V
authors.lastname: Olivier
authors.forename: Karla J Fullner
authors.initials: KJ
authors.lastname: Satchell
mesh_terms: D000818:Animals; D002771:Cholera / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002772:Cholera Toxin / Q000096:biosynthesis* / Q000235:genetics*; D022121:Cholera Vaccines / Q000276:immunology; D004195:Disease Models, Animal; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D011650:Pulmonary Alveoli / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D011971:Receptors, Immunologic / Q000502:physiology*; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014734:Vibrio cholerae / Q000276:immunology / Q000378:metabolism*
chemical_list: D022121:Cholera Vaccines; D007375:Interleukin-1; D011971:Receptors, Immunologic; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D002772:Cholera Toxin