Treatment of malabsorption vitamin D deficiency myopathy with intramuscular vitamin D.
A nearly 5 year-old boy presented with proximal muscle weakness, reduced muscle bulk, a positive Gower sign and Trendelenburg gait. He was known to have cholestatic liver disease. Investigations revealed markedly low serum total calcium, elevated alkaline phosphatase, very low serum 25-hydroxyvitamin D, and radiographs consistent with active rickets despite the ongoing administration of a water-soluble preparation of vitamin D. Only i.v. calcitriol acutely corrected the hypocalcemia, despite trying several oral preparations, suggesting that malabsorption secondary to chronic liver disease was the cause of his rickets. Intramuscular calciferol quickly corrected his muscle weakness and X-ray findings. Myopathy secondary to vitamin D deficiency is an uncommon diagnosis in children. Intermittent calciferol is an inexpensive and practical treatment for vitamin D deficiency, especially if associated with malabsorption.
Alyaarubi
Saif
S
Department of Endocrinology and Metabolism, Montreal Children's Hospital, Montreal, Quebec, Canada. Hawa34@hotmail.com
Rodd
Celia
C
D002675:Child, Preschool; D006801:Humans; D007273:Injections, Intramuscular; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000150:complications / Q000188:drug therapy*; D008297:Male; D018908:Muscle Weakness / Q000188:drug therapy / Q000209:etiology; D014807:Vitamin D / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy*
D014807:Vitamin D