title: Toxic megacolon complicating Escherichia coli O157 infection.
abstract: Toxic megacolon is a well known complication in inflammatory bowel disease such as ulcerative colitis or Crohn's disease. The development of toxic megacolon as a complication of infectious colitis is rare. However it is recognised as a complication of enteric infections caused by Clostridium difficile, Campylobacter jejuni, Shigella, Salmonella species, Cytomegalovirus and amoebae. We describe a case of necrotising haemorrhagic ileo-colitis in a previously fit and healthy young adult female caused by Escherichia coli O157 where toxic megacolon developed as a complication along with hemolytic uremic syndrome (HUS).
authors.affiliation: Department of Microbiology, Sunderland Royal Hospital, Sunderland SR4 7TP, UK.
authors.forename: Deepa M
authors.initials: DM
authors.lastname: Nayar
authors.forename: Shanmu
authors.initials: S
authors.lastname: Vetrivel
authors.forename: Jack
authors.initials: J
authors.lastname: McElroy
authors.forename: Pearl
authors.initials: P
authors.lastname: Pai
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Koerner
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000907:Antibodies, Bacterial / Q000097:blood; D002939:Ciprofloxacin / Q000008:administration & dosage; D003092:Colitis / Q000382:microbiology; D003106:Colon / Q000473:pathology / Q000601:surgery; D004927:Escherichia coli Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D019453:Escherichia coli O157 / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000382:microbiology; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008532:Megacolon, Toxic / Q000209:etiology* / Q000601:surgery; D008795:Metronidazole / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D000907:Antibodies, Bacterial; D007075:Immunoglobulin M; D008795:Metronidazole; D002939:Ciprofloxacin