[Sodium glutamate on some physiological features and chemically induced hepatocarcinogenesis in neontal period in male mice].
A single injection of diethylnitrosamine 50 mg/kg to 12-day old CBA mice led to development of 50.7 +/- 4.8 liver tumor nodules in males and 3.6 +/- 0.8 nodules in females. Only 19.0 +/- 3.6 tumor nodules developed in the liver of males who, prior to the carcinogen, received 5 intraperitoneal injections of monosodium glutamate (2-4 mg/g on alternate days from 1st to 9th days after birth). The glutamate-treated animals' body size diminished, as well as their weights of testes and seminal vesicles and blood testosterone concentration but, as a rule, quantity of body fat increased. The data obtained indicate that neonatal administration of monosodium glutamate to mice leads to disturbance of functional activity of sex steroids and presumably other hormones taking part in regulation of metabolism of body fat and energy.
Kaledin
V I
VI
Il'nitskaia
S I
SI
Kuznetsova
E G
EG
Amstislavskaia
T G
TG
D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D049628:Body Size / Q000187:drug effects; D004052:Diethylnitrosamine / Q000633:toxicity; D004734:Energy Metabolism / Q000187:drug effects; D005223:Fats / Q000378:metabolism; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000009:adverse effects*; D013739:Testosterone / Q000097:blood
D000477:Alkylating Agents; D005223:Fats; D005503:Food Additives; D004052:Diethylnitrosamine; D013739:Testosterone; D012970:Sodium Glutamate