Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.
An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent's potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, "strong but not sufficient" evidence of leukemia, and limited evidence of sinonasal cancer. The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans. These three evaluations and the supporting data will be published as Volume 88 of the IARC Monographs.
Cogliano
Vincent James
VJ
International Agency for Research on Cancer, Lyon, France.
Grosse
Yann
Y
Baan
Robert A
RA
Straif
Kurt
K
Secretan
Marie Béatrice
MB
El Ghissassi
Fatiha
F
D000818:Animals; D002274:Carcinogens, Environmental / Q000145:classification* / Q000633:toxicity*; D004202:Disinfectants / Q000633:toxicity; D005026:Ethylene Glycols / Q000633:toxicity*; D005404:Fixatives / Q000633:toxicity; D005557:Formaldehyde / Q000633:toxicity*; D006801:Humans; D007390:International Agencies; D007938:Leukemia / Q000209:etiology; D009303:Nasopharyngeal Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D016273:Occupational Exposure; D011409:Propylene Glycols / Q000633:toxicity*; D012997:Solvents / Q000633:toxicity
D002274:Carcinogens, Environmental; D004202:Disinfectants; D005026:Ethylene Glycols; D005404:Fixatives; D011409:Propylene Glycols; D012997:Solvents; D005557:Formaldehyde; C062586:n-butoxy-2-propanol; C017096:n-butoxyethanol