Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme.
Glioblastoma multiforme (GM) is the most lethal form of brain tumor, with a median survival of approximately 1 year. Treatment options are limited. Radiation therapy is a common form of treatment, but many tumors are resistant. In earlier studies, we found that gain of chromosome 7 is associated with radiation resistance in human primary GM. In this study, we extend that result to a model system in which we transferred chromosome 7 to recipient cells and confirmed radiation resistance as a function of chromosome 7 gain. We identified three candidate regions on chromosome 7 that conferred radiation resistance in our model system.
Misra
Anjan
A
Brain Tumor Research Center, Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143-0808, USA. amisra@cc.ucsf.edu
Pellarin
Malgorzata
M
Hu
Lily
L
Kunwar
Sandeep
S
Perhouse
Mark
M
Lamborn
Kathleen R
KR
Deen
Dennis F
DF
Feuerstein
Burt G
BG
D001932:Brain Neoplasms / Q000235:genetics* / Q000532:radiotherapy; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002874:Chromosome Mapping; D020223:Chromosome Painting; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics / Q000502:physiology*; D005909:Glioblastoma / Q000235:genetics* / Q000532:radiotherapy; D006801:Humans; D018895:Microsatellite Repeats; D011836:Radiation Tolerance / Q000235:genetics*