[Effect of Pinggan Xifeng decoction on hippocampal mitochondrial membrane potential after intracerebral hemorrhage in rat brain].
OBJECTIVE
To observe the effects of Pinggan Xifeng decoction (PGXFD) on the change of mitochondrial membrane potential (MMP) after intracerebral hemorrhage (ICH) injury in rat brain and to explore the mechanism of PGXF decoction in the treatment of ICH.


METHODS
VII type collagenase was stereotaxically injected into the globas pallidus of rats and spectrofluorometer was used to detect the fluorescence value of mitochondrial suspension. The neurobehavioral scores were used to evaluate the neurological defect.


RESULTS
Neurological function defects were seen after ICH in rats and PGXFD decreased the neurological grades. The MMP of rats with ICH was reduced significantly 4 hours after the operation, peaking at 1 d and was higher at 3 d and 7 d than that of the sham group . MMP in the PGXFD group was obviously higher than that in the control group at 1 d, 3 d, and 7 d.


CONCLUSIONS
MMP decreased in rats suffering from ICH. PGXFD can markedly depress the decreation of MMP.
Tan
Yong
Y
Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Liang
Qing-Hua
QH
Li
Xia-Ling
XL
D000818:Animals; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008564:Membrane Potentials; D008928:Mitochondria / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal