title: Hazardous waste sites and stroke in New York State.
abstract: BACKGROUND
  Environmental exposure to persistent organic pollutants (POPs) may lead to elevation of serum lipids, increasing risk of atherosclerosis with thromboembolism, a recognized cause of stroke. We tested the hypothesis that exposure to contaminants from residence near hazardous waste sites in New York State influences the occurrence of stroke.
  
  
  METHODS
  The rates of stroke hospital discharges were compared among residents of zip codes containing hazardous waste sites with POPs, other pollutants or without any waste sites using information for 1993-2000 from the New York Statewide Planning and Research Cooperative System (SPARCS) database, containing the records of all discharge diagnoses for patients admitted to state-regulated hospitals.
  
  
  RESULTS
  After adjustment for age and race, the hospitalization rate for stroke in zip codes with POPs-contaminated sites was 15% higher than in zip codes without any documented hazardous waste sites (RR 1.15, 95% CI, 1.05, 1.26). For ischemic stroke only, the RR was 1.17 (95% CI 1.04, 1.31). Residents of zip codes containing other waste sites showed a RR of 1.13 (95% CI, 1.02, 1.24) as compared to zip codes without an identified waste site.
  
  
  CONCLUSIONS
  These results suggest that living near a source of POPs contamination constitutes a risk of exposure and an increased risk of acquiring cerebrovascular disease. However further research with better control of individual risk factors and direct measurement of exposure is necessary for providing additional support for this hypothesis.
authors.affiliation: Department of Environmental Health and Toxicology, School of Public Health, University at Albany, SUNY, One University Place, Rensselaer, NY 12144, USA. shcheriy@mcmaster.ca
authors.forename: Ivan
authors.initials: I
authors.lastname: Shcherbatykh
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Huang
authors.forename: Lawrence
authors.initials: L
authors.lastname: Lessner
authors.forename: David O
authors.initials: DO
authors.lastname: Carpenter
mesh_terms: D000328:Adult; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006256:Hazardous Waste / Q000009:adverse effects*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D010351:Patient Discharge; D011083:Polycyclic Compounds / Q000633:toxicity*; D011177:Postal Service; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology
chemical_list: D004785:Environmental Pollutants; D006256:Hazardous Waste; D011083:Polycyclic Compounds