Evaluation of anticardiolipin antibodies and antiphosphatidylserine antibodies in women with recurrent abortion.
BACKGROUND
Antiphospholipid syndrome (APS) is a major reproductive complication in women, which is characterized by recurrent fetal loss, thrombosis, and thrombocytopenia in association with anticardiolipin antibodies (aCL).


OBJECTIVE
To analyze the prevalence of aCL and antiphosphatidylserine antibodies (aPS) in relation to pregnancy failures in women with the history of recurrent spontaneous abortion.


METHODS
A sequential study of 155 patients, who had three or more recurrent spontaneous abortions, was carried out.


METHODS
Women with unexplained recurrent pregnancy loss in first trimester were selected for this study. Anticardiolipin antibodies IgG and aPS IgG were detected in the serum by the enzyme linked immunosorbent assay method.


METHODS
Percentage calculation was carried out. Two-tailed t-test was performed to know the significance of aCL and aPS total population.


RESULTS
The levels of aCL IgG and aPS IgG were detected as 40% (62) and 19% (18), respectively in women with history of recurrent abortion.


CONCLUSIONS
Anticardiolipin antibody is found to be the most important factor for recurrent abortion. In addition, women with negative aCL are having positive for another antiphospholipid antibodies like aPS, which may involve in recurrent abortion.
Velayuthaprabhu
S
S
Department of Animal Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Archunan
G
G
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D017152:Antibodies, Antiphospholipid / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D010718:Phosphatidylserines / Q000276:immunology*; D011247:Pregnancy
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D010718:Phosphatidylserines