title: Coenzyme Q10 protects from aging-related oxidative stress and improves mitochondrial function in heart of rats fed a polyunsaturated fatty acid (PUFA)-rich diet.
abstract: Coenzyme Q(10) supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q(10). Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, alpha-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a(3), b, c+c(1) and cytochrome c oxidase activity were measured. Coenzyme Q(10)-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of alpha-tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. According to that, previously reported positive effects of coenzyme Q supplementation on the life span of rats fed a PUFA-rich diet might be a consequence, at least in part, of a lower oxidative stress level and perhaps, to a minor extent, of a smaller decrease in mitochondrial function.
authors.affiliation: Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain. jjoh@ugr.es
authors.forename: Julio J
authors.initials: JJ
authors.lastname: Ochoa
authors.forename: José L
authors.initials: JL
authors.lastname: Quiles
authors.forename: Jesús R
authors.initials: JR
authors.lastname: Huertas
authors.forename: José
authors.initials: J
authors.lastname: Mataix
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D003067:Coenzymes; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D003576:Electron Transport Complex IV / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000378:metabolism
chemical_list: D003067:Coenzymes; D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D014451:Ubiquinone; D002374:Catalase; D005979:Glutathione Peroxidase; D003576:Electron Transport Complex IV; C024989:coenzyme Q10; D024502:alpha-Tocopherol; C030571:ubiquinone 9