title: Preterm premature rupture of membranes: perspectives surrounding controversies in management.
abstract: Preterm premature rupture of the membranes (PPROM) occurs in approximately 3% of all pregnancies, and accounts for one third of all preterm births. Despite its prevalence, optimal management of PPROM remains largely undefined and lacks conformity. In this article, we review the pathophysiology of PPROM, and summarize the available literature describing various management strategies in an effort to define current controversies in the management of PPROM.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City, Utah, USA.
authors.forename: Kjersti M
authors.initials: KM
authors.lastname: Aagaard-Tillery
authors.forename: Francis S
authors.initials: FS
authors.lastname: Nuthalapaty
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Ramsey
authors.forename: Kirk D
authors.initials: KD
authors.lastname: Ramin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D036861:Delivery, Obstetric / Q000379:methods; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D010500:Perinatology / Q000379:methods* / Q000639:trends*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D015145:Tocolysis / Q000379:methods
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents