title: Suppressive effect of trehalose on acrylamide formation from asparagine and reducing saccharides.
abstract: The influence of saccharides on the formation of acrylamide (AcA) was investigated. The reducing saccharides reacted with asaparagine to form AcA, but the non-reducing saccharides, except sucrose, gave no AcA. AcA formation from a mixture containing glucose and asaparagaine was suppressed by the non-reducing saccharides, especially trehalose (76% suppression) and neotrehalose (75% suppression). Glucose is heat-degraded into pyruvaldehyde and 5-hydroxymethyl-2-furfural in the water system. The degradation products react with asparagines to generate AcA. Trehalose appears to inhibit not only the formation of these intermediates and asparagines for AcA, but also the AcA formation from these intermediates.
authors.affiliation: Amase Institute, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan. okukaz@hayashibara.co.jp
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Oku
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kurose
authors.forename: Tohru
authors.initials: T
authors.lastname: Ogawa
authors.forename: Michio
authors.initials: M
authors.lastname: Kubota
authors.forename: Hiroto
authors.initials: H
authors.lastname: Chaen
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Fukuda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsujisaka
mesh_terms: D020106:Acrylamide / Q000138:chemical synthesis*; D001216:Asparagine / Q000737:chemistry*; D002849:Chromatography, Gas; D005947:Glucose / Q000737:chemistry*; D007700:Kinetics; D013395:Sucrose / Q000737:chemistry*; D014199:Trehalose / Q000737:chemistry*
chemical_list: D020106:Acrylamide; D013395:Sucrose; D001216:Asparagine; D014199:Trehalose; D005947:Glucose