title: [Castleman's disease].
abstract: OBJECTIVE
  To describe original experience in management of Castleman's disease (CD) and review literature data.
  
  
  METHODS
  Twelve cases of HIV-free CD in patients aged 18-51 years (mean age 36 years) are reported.
  
  
  RESULTS
  CD was plasmocell, mixed and hyalinovascular in 6, 2 and 4 patients, respectively. Histological and immunophenotypical characteristics of CD are detailed. Three patients with plasmocell CD died of severe autoimmune anemia. All the patients with hyalinovascular KD variant were treated surgically (enlarged lymph nodes were removed) and achieved remission.
  
  
  CONCLUSIONS
  The diagnosis of plasmocell CD is made after exclusion of infections, collagenoses, autoimmune diseases and lymphomas. Therapy of plasmocell variant of CD has not been developed yet.
authors.forename: A L
authors.initials: AL
authors.lastname: Melikian
authors.forename: I B
authors.initials: IB
authors.lastname: Kaplanskaia
authors.forename: E P
authors.initials: EP
authors.lastname: Korneva
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
mesh_terms: D000293:Adolescent; D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications; D005871:Castleman Disease / Q000150:complications / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology