Two new meroterpenoids, penisimplicin A and B, isolated from Penicillium simplicissimum.
In the course of our research for new antifungal agents, two new meroterpenoids, penisimplicin A (1) and B (2), were isolated from Penicillium simplicissimum. The absolute structures of 1 and 2 were established by spectroscopic and chemical investigation. Penisimplicin A (1) and B (2) are rare examples of D-ring seco-meroterpenoids. Since compounds 1 and 2 showed no antifungal activities, the isolation of the compounds with antifungal activity will be attempted.
Komai
Shin-Ichirou
S
Faculty of Pharmaceutical Sciences, Hoshi University; 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Hosoe
Tomoo
T
Itabashi
Takeshi
T
Nozawa
Koohei
K
Okada
Kaoru
K
Campos Takaki
Galba Maria de
GM
Yaguchi
Takashi
T
Takizawa
Kayoko
K
Fukushima
Kazutaka
K
Kawai
Ken-Ichi
K
D000935:Antifungal Agents / Q000737:chemistry*; D001894:Borohydrides; D002236:Carbohydrate Conformation; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D006868:Hydrolysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D010407:Penicillium / Q000737:chemistry*
D000935:Antifungal Agents; D001894:Borohydrides; D007202:Indicators and Reagents; C025364:sodium borohydride; D000432:Methanol