Evaluation of the inhibitory activities of the extracts of Indonesian traditional medicinal plants against Plasmodium falciparum and Babesia gibsoni.
Twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment of malaria on Java Island, Indonesia, were screened for their antibabesial and antimalarial activities. Among the extracts, 8 extracts displayed strong antimalarial activity, with an inhibition range from 89.6 to 100%, and 15 showed strong antibabesial activity, with an inhibition range from 84.2 to 98.1%. The extracts of Achillea millefolium, Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida and Swietenia macrophylla showed both strong antibabesial and antimalarial activities. The antimalarial activities paralleled the antibabesial activities, but the converse was not true.
Murnigsih
Tri
T
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Subeki
Matsuura
Hideyuki
H
Takahashi
Kosaku
K
Yamasaki
Masahiro
M
Yamato
Osamu
O
Maede
Yoshimitsu
Y
Katakura
Ken
K
Suzuki
Mamoru
M
Kobayashi
Sumiko
S
Chairul
Yoshihara
Teruhiko
T
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000633:toxicity*; D001403:Babesia / Q000187:drug effects*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000981:Antiprotozoal Agents; D010936:Plant Extracts