title: Genome-wide linkage analyses of type 2 diabetes in Mexican Americans: the San Antonio Family Diabetes/Gallbladder Study.
abstract: The San Antonio Family Diabetes/Gallbladder Study was initiated to identify susceptibility genes for type 2 diabetes. Evidence was previously reported of linkage to diabetes on 10q with suggestive evidence on 3p and 9p in a genome-wide scan of 440 individuals from 27 pedigrees ascertained through a single diabetic proband. Subsequently, the study was expanded to include 906 individuals from 39 extended Mexican-American pedigrees, two additional examination cycles approximately 5.3 and 7.6 years after baseline, and genotypes for a new set of genome-wide markers. Therefore, we completed a second genome-wide linkage scan. Using information from a participant's most recent exam, the prevalence of diabetes in nonprobands was 21.8%. We performed genome-wide variance components-based genetic analysis on the discrete trait diabetes using a liability model and on the quantitative Martingale residual obtained from modeling age of diabetes diagnosis using Cox proportional hazard models. Controlling for age and age(2), our strongest evidence for linkage to the trait diabetes and the quantitative Martingale residual was on chromosome 3p at marker D3S2406 with multipoint empirical logarithm of odds scores of 1.87 and 3.76, respectively. In summary, we report evidence for linkage to diabetes on chromosome 3p in a region previously identified in at least three independent populations.
authors.affiliation: Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA. huntk@uthscsa.edu
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Hunt
authors.forename: Donna M
authors.initials: DM
authors.lastname: Lehman
authors.forename: Rector
authors.initials: R
authors.lastname: Arya
authors.forename: Sharon
authors.initials: S
authors.lastname: Fowler
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Leach
authors.forename: Harald H H
authors.initials: HH
authors.lastname: Göring
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Tom D
authors.initials: TD
authors.lastname: Dyer
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Duggirala
authors.forename: Michael P
authors.initials: MP
authors.lastname: Stern
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio
chemical_list: D005819:Genetic Markers