Gene expression profiling in whole cerebral cortices of phencyclidine- or methamphetamine-treated rats.
Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes. The number of MAP-, PCP-, and MAP and PCP-reactive tags were 229, 215, and 41, respectively.
Ouchi
Yuta
Y
Department of Psychiatry, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Kubota
Yasuhiko
Y
Kuramasu
Atsuo
A
Watanabe
Takehiko
T
Ito
Chihiro
C
D000818:Animals; D001483:Base Sequence; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004249:DNA Damage; D017931:DNA Primers; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000235:genetics; D010622:Phencyclidine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D017931:DNA Primers; D009419:Nerve Tissue Proteins; D008694:Methamphetamine; D010622:Phencyclidine