title: Medical history of circulatory diseases and colorectal cancer death in the JACC Study.
abstract: BACKGROUND
  Host factors expressed by individual past medical history of hypertension, stroke, and myocardial infarction may have a relationship with colorectal cancer.
  
  
  METHODS
  As part of the Japan Collaborative Cohort Study (JACC Study) for the Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho), we conducted a follow-up study of 110,792 Japanese inhabitants aged 40-79 years to reveal the relationship of past medical history of hypertension, stroke, and myocardial infarction at the baseline in 1988-1990 with colorectal cancer death for about 10 years up to the end of 1999.
  
  
  RESULTS
  Past medical history of hypertension associated with an increased risk of female rectal cancer when analyzing all cancer cases with adjustment for age, body mass index, and exercise (hazard ratio [HR]=1.97, 95% confidence interval [CI]; 1.13-3.43). Past medical history of myocardial infarction was also an increased risk for female rectal cancer (HR=3.05, 95% CI; 1.28-7.28). Females who had a medical history of stroke had increased risk of rectal cancer without statistical significance.
  
  
  CONCLUSIONS
  There was a positive association of past medical history of hypertension and myocardial infarction and an increased risk of rectal cancer in women.
authors.affiliation: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Japan. watanabe@koto.kpu-m.ac.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Kotaro
authors.initials: K
authors.lastname: Ozasa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masayo
authors.initials: M
authors.lastname: Kojima
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kawado
authors.forename: Shuji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Norihiko
authors.initials: N
authors.lastname: Hayakawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*; D011795:Surveys and Questionnaires