Palladium-catalyzed annulation of arynes by 2-halobenzaldehydes: synthesis of fluoren-9-ones.
Arynes, generated in situ from 2-(trimethylsilyl)aryl triflates and CsF, undergo annulation by o-haloarenecarboxaldehydes in the presence of a Pd catalyst, providing a useful new method for the synthesis of fluoren-9-ones in good yields. [reaction: see text]
Zhang
Xiaoxia
X
Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
Larock
Richard C
RC
D020650:Combinatorial Chemistry Techniques; D005449:Fluorenes / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D005449:Fluorenes; D006846:Hydrocarbons, Halogenated; D010165:Palladium; C028401:9-fluorenone