Congenital dyserythropoietic anemia type I (CDA I): molecular genetics, clinical appearance, and prognosis based on long-term observation.
Congenital dyserythropoietic anemia type I (CDA I) is a rare autosomal recessive disorder with ineffective erythropoiesis and iron overloading. More than 100 cases have been described, but with the exception of a report on a large Bedouin tribe, these reports include only small numbers of cases, and no data on the lifetime evolution of the disease are available. Since 1967, we have been able to follow 21 cases from 19 families for up to 37 years. Twenty-one patients with a confirmed diagnosis of CDA I exhibited chronic macrocytic anemia of variable severity, requiring regular red cell transfusions only in 2 individuals. Four developed gallstones before the age of 30 years. Fifteen of 16 cases alive at the time of analysis showed mutations of at least one allele from exons 6 to 28 within CDAN1. Iron overloading is to be expected in all patients. In 9 patients, iron depletion was started between the ages of 7 and 36 years. Splenectomy, which was performed in 7 patients, did not result in improvement of hemoglobin values. Five patients were treated with interferon alpha-2a, and all responded with a rise in hemoglobin concentration of between 25 and 35 g/L (2.5 and 3.5 g/dL) starting within 4 weeks.
Heimpel
Hermann
H
Department of Internal Medicine III, University of Ulm, Germany, Robert Koch Strasse 8, D-89081 Ulm, Germany. hermann.heimpel@medizin.uni-ulm.de
Schwarz
Klaus
K
Ebnöther
Monika
M
Goede
Jeroen S
JS
Heydrich
Detlev
D
Kamp
Torsten
T
Plaumann
Lothar
L
Rath
Bettina
B
Roessler
Jochen
J
Schildknecht
Otto
O
Schmid
Mathias
M
Wuillemin
Walter
W
Einsiedler
Beate
B
Leichtle
Rosi
R
Tamary
Hannah
H
Kohne
Elisabeth
E
D000293:Adolescent; D000328:Adult; D000742:Anemia, Dyserythropoietic, Congenital / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000748:Anemia, Macrocytic; D002648:Child; D005091:Exons; D005192:Family Health; D005260:Female; D042882:Gallstones; D005858:Germany / Q000453:epidemiology; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007501:Iron / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009687:Nuclear Proteins; D011379:Prognosis; D011994:Recombinant Proteins; D013156:Splenectomy
C470477:CDAN1 protein, human; D006023:Glycoproteins; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009687:Nuclear Proteins; D011994:Recombinant Proteins; D007501:Iron