[Advance in the entire balance and local unbalance of base distribution in genome].
With more and more genome have been completely sequenced, scientists find the Partial Rule 2 (PR2) in entire single strand that A approximately equal to T, G approximately equal to C. But from the scope of thousands to hundreds of thousand bases, A not = T, G not = C. From the view of math, if the mutational rate of one strand is equal to others, it could be proved that A approximately equal to T, G approximately equal to C, but from the view of experience, that premise doesn't exist, so the solution of the problem needs the deeply combination of biology and math.
Zhong
Dong
D
Gastroenterology Department, Nanfan Hospital, Guangzhou 510515, China.
Zhao
Gui-Jun
GJ
Zhang
Zhen-Shu
ZS
Xun
An-Long
AL