title: Control, immunoregulation, and expression of innate pulmonary host defenses against Aspergillus fumigatus.
abstract: The innate host defense system (IHDS) against Aspergillus fumigatus includes dedicated phagocytic cells (peripheral blood monocytes, monocyte derived macrophages, pulmonary alveolar macrophages, neutrophils, myeloid dendritic cells and natural killer cells), cytokines, chemokines, toll-like receptors, and antimicrobial peptides. During the past decade, the advances in the field of the IHDS have been enormous, allowing a better understanding of the immunopharmacological control, immunoregulation, and expression of innate host defense molecules against Aspergillus fumigatus.
authors.affiliation: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bldg. 10, Rm 13N-240, 10 Center Drive, Bethesda, MD 20892, USA. walsht@mail.nih.gov
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: E
authors.initials: E
authors.lastname: Roilides
authors.forename: K
authors.initials: K
authors.lastname: Cortez
authors.forename: S
authors.initials: S
authors.lastname: Kottilil
authors.forename: J
authors.initials: J
authors.lastname: Bailey
authors.forename: C A
authors.initials: CA
authors.lastname: Lyman
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001228:Aspergillosis / Q000276:immunology* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000472:pathogenicity*; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology*; D008172:Lung Diseases, Fungal / Q000276:immunology* / Q000382:microbiology; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D010586:Phagocytes / Q000166:cytology / Q000276:immunology; D011956:Receptors, Cell Surface / Q000378:metabolism; D051193:Toll-Like Receptors
chemical_list: D023181:Antimicrobial Cationic Peptides; D016207:Cytokines; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors