title: [Advance in the entire balance and local unbalance of base distribution in genome].
abstract: With more and more genome have been completely sequenced, scientists find the Partial Rule 2 (PR2) in entire single strand that A approximately equal to T, G approximately equal to C. But from the scope of thousands to hundreds of thousand bases, A not = T, G not = C. From the view of math, if the mutational rate of one strand is equal to others, it could be proved that A approximately equal to T, G approximately equal to C, but from the view of experience, that premise doesn't exist, so the solution of the problem needs the deeply combination of biology and math.
authors.affiliation: Gastroenterology Department, Nanfan Hospital, Guangzhou 510515, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhong
authors.forename: Gui-Jun
authors.initials: GJ
authors.lastname: Zhao
authors.forename: Zhen-Shu
authors.initials: ZS
authors.lastname: Zhang
authors.forename: An-Long
authors.initials: AL
authors.lastname: Xun