HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication.
We identified a total 15 patients who have maintained undetectable plasma HIV RNA loads without antiretroviral treatment for >10 years from cohorts of 1300 and 1551 patients infected with human immunodeficiency virus (HIV). These 15 patients, whom we have referred to as "HIV controllers," are characterized by a low HIV DNA load in peripheral blood mononuclear cells and by a strong HIV-specific immune response.
Lambotte
Olivier
O
INSERM E-0109, Faculté de Médecine Paris-Sud, Université Paris XI, Service de Santé Publique, Bicêtre, France. olivier.lambotte@bct.ap-hop-paris.fr
Boufassa
Faroudy
F
Madec
Yoann
Y
Nguyen
Ahn
A
Goujard
Cécile
C
Meyer
Laurence
L
Rouzioux
Christine
C
Venet
Alain
A
Delfraissy
Jean-François
JF
D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D019562:Viral Load; D014779:Virus Replication / Q000502:physiology*
D012367:RNA, Viral