Histogenesis of intralesional fibrous septum in chordoma.
Intralesional fibrous septum (IFS), a histologic architecture that is typical of chordoma, consists of proliferating spindle-shaped, fibroblast-like cells with an abundance of collagen fibers. However, the histogenesis of IFS is still controversial. In a series of 122 chordomas, special emphasis was placed on the morphology of host tissues involved in IFS and on a transition between IFS and neighboring tissues. In 23 lesions, IFS was also characterized both histochemically and immunohistochemically. IFS was observed in 79 (64.8%) lesions. Occasionally, IFS contained bone fragments and hyalinized matrix with no lining of osteoblastic cells, suggesting degenerated rather than metaplastic bone tissue. Moreover, IFS occasionally showed a direct transition to host bone trabeculae. Histochemically and immunohistochemically, IFS included calcium deposits positive for Alizarin red S staining and expressed both type I and type III collagen. In extraosseous lesions extending to the adjacent soft tissues, IFS frequently involved muscle fibers or peripheral nerve fibers and displayed a smooth transition to neighboring soft tissues. We believe that IFS is induced by a tumor-host interaction that is based on the host bone trabeculae in intraosseous lesions or on soft tissues in extraosseous lesions.
Naka
Takahiko
T
Department of Pathology, Faculty of Medicine, Magdeburg University, Magdeburg, Germany. takahicom@hotmail.com
Boltze
Carsten
C
Kuester
Doerthe
D
Samii
Amir
A
Herold
Christian
C
Ostertag
Helmut
H
Iwamoto
Yukihide
Y
Odae
Yoshinao
Y
Tsuneyoshi
Masazumi
M
Roessner
Albert
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000880:Anthraquinones; D002118:Calcium / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002817:Chordoma / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D004396:Coloring Agents; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling
D000880:Anthraquinones; D004396:Coloring Agents; C010078:alizarin; D003094:Collagen; D002118:Calcium