title: Prostate biopsy: is age important for determining the pathological features in prostate cancer?
abstract: BACKGROUND
  The influence of age on the aggressiveness of prostate cancer (PCa) is controversial. This study aims to assess the influence of age in determining the pathological features of biopsies from patients diagnosed with PCa.
  
  
  METHODS
  We selected 1422 patients with clinical suspicion of PCa; among them, 547 (38.5%) had received a diagnosis of adenocarcinoma. Patients were categorized into the following age groups: up to 50 years old, 51 to 60 years, 61 to 70 years, 71 to 80 years, and over 80 years. The evaluated variables were histological grade, presence of perineural invasion and estimate of tumor volume through measurement of the maximum percentage of tissue with cancer in one fragment and total percentage of tissue with cancer in the sample.
  
  
  RESULTS
  The mean age of patients was 66.4 years, with age range from 32 to 94 years. The estimate of tumor volume by maximum percentage of tissue with cancer in one fragment (p = 0.064), total percentage of tissue with cancer in the sample (p = 0.443), and Gleason score (p = 0.485) were not statistically different in relation to the age groups under study. The presence of perineural invasion occurred more frequently among the 50 years and 81 years age groups when compared with patients aged from 51 to 60 and from 61 to 80 years (p = 0.005).
  
  
  CONCLUSIONS
  Age did not represent a determining factor for pathological findings concerning Gleason score and estimate of tumor volume by the variables in use.
authors.affiliation: Laboratory of Surgical and Molecular Pathology, Syrian Lebanese Hospital, Sao Paulo, SP, Brazil. betoazoubel@yahoo.com.br
authors.forename: Alberto A
authors.initials: AA
authors.lastname: Antunes
authors.forename: Katia R
authors.initials: KR
authors.lastname: Leite
authors.forename: Marcos F
authors.initials: MF
authors.lastname: Dall'Oglio
authors.forename: Alexandre
authors.initials: A
authors.lastname: Crippa
authors.forename: Luciano J
authors.initials: LJ
authors.lastname: Nesrallah
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*