Morphological changes in immune and endocrine organs of mice injected with a gonadotropin-releasing hormone analog.
Infection of surfagon (gonadotropin-releasing hormone analog) in a dose of 0.1 microg/kg to male CBA mice stimulated lymphocyte migration from splenic B zones, caused moderate thinning of the thymic cortex, thickening of the zona fasciculata of the adrenal cortex with signs of corticocyte activation. After administration of 5 microg/kg surfagon we observed alteration of the splenic T zone, drastic thinning of the thymic cortex, and extension of the zona glomeruloza in the adrenal cortex. These effects were retained after castration, which attests to their steroid-independent nature.
Bobyntsev
I I
II
Department of Pathophysiology, Department of Histology, Kursk State Medical University, Russia. big@ksmu.kursknet.ru
Dolzhikov
A A
AA
Severyanova
L A
LA
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects*; D000818:Animals; D002465:Cell Movement; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*
D007987:Gonadotropin-Releasing Hormone; C010661:surfagon