title: [Prevalence of thrombophilia in patients with severe ovarian hyperstimulation syndrome].
abstract: OBJECTIVE
  To determine the prevalence of markers of thrombophilia in patients with severe form of ovarian hyperstimulation syndrome
  
  
  METHODS
  Retrospective case - control study
  
  
  METHODS
  Unica, Institute for Reproductive Medicine, Brno
  
  
  METHODS
  Blood samples to test for markers of thrombophilia were obtained from 30 patients who were hospitalised for severe OHSS. Results were compared with two control groups.
  
  
  RESULTS
  None of the patients with severe OHSS had antithrombin, protein C or protein S deficiencies. We also did not observe increased prothrombin level. Six patients had factor V Leiden mutation (heterozygotes) which is statistically significant compared to control group (p = 0.01, OR 4.65) and 12 patients had mutation of MTHFR 677 (heterozygotes). None had prothrombin G20210A mutation.
  
  
  CONCLUSIONS
  We found a statistically significant increase in the prevalence of factor V Leiden mutation (heterozygot) in Czech infertile women with severe OHSS. These findings suggest the increased risk of development of OHSS in these patients.
authors.affiliation: Klinika pro lécbu neplodnosti Unica, Brno.
authors.forename: S
authors.initials: S
authors.lastname: Machac
authors.forename: M
authors.initials: M
authors.lastname: Procházka
authors.forename: M
authors.initials: M
authors.lastname: Lubuský
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood*; D011247:Pregnancy; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)