Histologic implications of Pap smears classified as atypical glandular cells.
OBJECTIVE
To evaluate the histologic outcome of Pap smears reported as atypical glandular cells (AGC).


METHODS
Cervical cytology smears reported as AGC were reviewed and correlated with histologic follow-up.


RESULTS
Of a total of 41,500 Pap smears performed at Alexandra Hospital during 2000-2002, 113 (0.2%) were reported as AGC. Of these, 64 were classified as AGC not otherwise specified (NOS) (56.6%), 48 AGC favor neoplasia (42.5%) and 1 (0.9%) adenocarcinoma in situ. All these women underwent histological evaluation. The mean age of the patients was 52 years. Significant abnormality was found in 30 women (26.5%). Eleven percent of women with smears reported as AGC NOS and 45.8% of those with AGC favor neoplasia had significant abnormality. Of these patients, 14 (12.4%) had endometrial involvement, whereas cervical abnormalities were identified in the remaining 16 (14.1%). Older women were more likely to have involvement of the endometrium and younger women, involvement of the cervix.


CONCLUSIONS
Cytologic criteria and patient age might effectively direct the clinician toward the likely origin of AGC.
Haidopoulos
Dimitrios A
DA
Department of Gynecological Oncology, Athens University, Alexandra Hospital, Athens, Greece. dhaidopoulos@hotmail.com
Stefanidis
Konstantinos
K
Rodolakis
Alexandros
A
Pilalis
Athanasios
A
Symiakaki
Ira
I
Diakomanolis
Emmanuel
E
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002584:Cervix Uteri / Q000166:cytology* / Q000473:pathology*; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology; D014626:Vaginal Smears