Genotype frequencies at codon 129 of the prion protein gene in Brazil: Implications in susceptibility to variant Creutzfeldt-Jakob disease compared to European and Asian populations.
A polymorphism at codon 129 of the prion protein gene has been shown to confer genetic susceptibility to prion diseases, and to influence the epidemic course of variant Creutzfeldt-Jakob disease. We employed a PCR-endonuclease digestion-based assay to investigate this genetic trait in Brazil, and then compared our results to previously published data from several European and Asian countries.
de Paula
Erich Vinicius
EV
Haematology and Haemotherapy Centre, State University of Campinas, Rua Carlos Chagas 480, CEP 13083-970 Campinas, SP, Brazil.
Addas-Carvalho
Marcelo
M
Costa
Devanira Souza Paixao
DS
Saad
Sara Terezinha Olalla
ST
Gilli
Simone Cristina Olenscki
SC
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D001938:Brazil; D003062:Codon / Q000235:genetics*; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D008875:Middle Aged; D010446:Peptide Fragments / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D044465:White People / Q000235:genetics
D003062:Codon; D010446:Peptide Fragments; D011328:Prions; C417024:prion protein (127-147)