Breast myeloma: a report of 3 cases with fine needle aspiration cytologic findings.
BACKGROUND
Multiple myeloma of the breast is very rare, and the fine needle aspiration (FNA) findings have not been reported before.


METHODS
Two cases of multiple myeloma presented with bilateral breast nodules during treatment with chemotherapy. One case of multiple myeloma presented initially with a left breast mass. FNA smears of all 3 cases revealed numerous plasma cells, plasmablasts and multinucleated giant plasma cells. The smears were diagnosed as plasma cell tumors. Serum immunoelectrophoresis revealed IgG myeloma in 2 cases and IgA myeloma in 1. Marrow aspirates revealed > 30% plasma cells. Two patients died, and 1 was alive at this writing.


CONCLUSIONS
The aspiration cytology findings of myeloma can be confuse, with primary and secondary tumors of the breast. The previous clinical history and ancillary studies, such as bone marrow study and serum immunoelectrophoresis, are essential to the correct diagnosis.
Kumar
Perikala V
PV
Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. kumarv@sums.ac.ir
Vasei
Mohammad
M
Daneshbod
Yahya
Y
Zakerinia
Maryam
M
Ramzi
Mani
M
Noorani
Habib
H
Bagheri
Hadi
H
Talei
Abdul Rasool
AR
Soleimanpour
Hossein
H
D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D008327:Mammography; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D010954:Plasmacytoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology