title: Genes involved in Alzheimer's disease, a survey of possible candidates.
abstract: Alzheimer's disease (AD) is the major cause of dementia in the elderly. It is characterized by a progressive deterioration in memory and cognitive functions, but also behavioral symptoms are common. Many different genes are possibly involved in Alzheimer's Disease: four genetic factors were confirmed in different studies, while at least 50 additional genes were tested with contrasting results. A major aim both for clinician and researchers would be the identification of the genes involved in AD, to better understand the biological mechanism of this disease and consequently to develop appropriate treatments. The aim of this review is to explore genetics of AD.
authors.affiliation: Department of Psychiatry, Vita-Salute University School of Medicine, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy. serretti.alessandro@hsr.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Paola
authors.initials: P
authors.lastname: Artioli
authors.forename: Roberto
authors.initials: R
authors.lastname: Quartesan
authors.forename: Diana
authors.initials: D
authors.lastname: De Ronchi
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D020789:Cathepsin C / Q000235:genetics / Q000378:metabolism; D056649:Cathepsin G; D002403:Cathepsins / Q000235:genetics / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics; D016202:N-Methylaspartate / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000378:metabolism; D058225:Plaque, Amyloid / Q000473:pathology; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins; D009435:Synaptic Transmission / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D016202:N-Methylaspartate; D014365:Tryptophan Hydroxylase; D002403:Cathepsins; D020789:Cathepsin C; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G