title: Regulation of 5-lipoxygenase enzyme activity.
abstract: In this article, regulation of human 5-lipoxygenase enzyme activity is reviewed. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase and nuclear localization sequences are reviewed.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-17177 Stockholm, Sweden. olof.radmark@mbb.ki.se
authors.forename: Olof
authors.initials: O
authors.lastname: Rådmark
authors.forename: Bengt
authors.initials: B
authors.lastname: Samuelsson
mesh_terms: D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans
chemical_list: D001094:Arachidonate 5-Lipoxygenase