title: [The polypill: not an effective strategy for reduction of cardiovascular disease].
abstract: The implementation of the intriguing concept of the polypill to prevent cardiovascular events remains doubtful due to a lack of evidence, expected adherence problems, the inevitable overtreatment and undertreatment of individuals, and potential side effects. Lifestyle changes and individual interventions are more preferable strategies.
authors.affiliation: Universitair Medisch Centrum Utrecht, afd. Vasculaire Geneeskunde, Heidelberglaan 100, 3584 CX Utrecht.
authors.forename: P E
authors.initials: PE
authors.lastname: Westerweel
authors.forename: J P H
authors.initials: JP
authors.lastname: van Wijk
authors.forename: M C
authors.initials: MC
authors.lastname: Verhaar
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control*; D004338:Drug Combinations; D019317:Evidence-Based Medicine; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D011322:Primary Prevention
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010975:Platelet Aggregation Inhibitors; D005492:Folic Acid; D001241:Aspirin