[Prevalence of thrombophilia in patients with severe ovarian hyperstimulation syndrome].
OBJECTIVE
To determine the prevalence of markers of thrombophilia in patients with severe form of ovarian hyperstimulation syndrome


METHODS
Retrospective case - control study


METHODS
Unica, Institute for Reproductive Medicine, Brno


METHODS
Blood samples to test for markers of thrombophilia were obtained from 30 patients who were hospitalised for severe OHSS. Results were compared with two control groups.


RESULTS
None of the patients with severe OHSS had antithrombin, protein C or protein S deficiencies. We also did not observe increased prothrombin level. Six patients had factor V Leiden mutation (heterozygotes) which is statistically significant compared to control group (p = 0.01, OR 4.65) and 12 patients had mutation of MTHFR 677 (heterozygotes). None had prothrombin G20210A mutation.


CONCLUSIONS
We found a statistically significant increase in the prevalence of factor V Leiden mutation (heterozygot) in Czech infertile women with severe OHSS. These findings suggest the increased risk of development of OHSS in these patients.
Machac
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Klinika pro lécbu neplodnosti Unica, Brno.
Procházka
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Lubuský
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D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood*; D011247:Pregnancy; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)