title: Modeling impact of parathion and its metabolite paraoxon on the nematode Caenorhabditis elegans in soil.
abstract: Parathion is an insecticide of a group of highly toxic organophosphorous compounds. In vivo, it is activated to the toxic metabolite paraoxon. Laboratory experiments have shown that a single relationship between the variable (concentration x time of application) and the percentage of paralyzed nematodes is relevant. Aqueous (0.01 M CaCl2) extracts from soil that had received a dose of parathion as used in practice during an incubation experiment had no effect on nematodes, because sorption and biodegradation of the pesticide decreased the pesticide concentration in the soluble phase. To predict the toxicological effects of parathion and paraoxon on nematodes under various soil conditions during a simulation period of 20 d, we used a model predicting the concentrations of parathion and paraoxon over time in the soil liquid phase. In this model, sorption and biodegradation of both parathion and paraoxon were taken into account, and the results indicated that sorption effects were dominant and determined the differential toxicological risks between soils. Variable effects were predicted for short times (typically <5 d), and critical toxicological conditions were predicted for longer duration (typically >10-15 d), in all cases.
authors.affiliation: CSE-Sol, INRA, Domaine St Paul, Site Agroparc, 84914 Avignon Cedex 09, France.
authors.forename: Kawtar
authors.initials: K
authors.lastname: Saffih-Hdadi
authors.forename: Laurent
authors.initials: L
authors.lastname: Bruckler
authors.forename: Marcel
authors.initials: M
authors.lastname: Amichot
authors.forename: Luc
authors.initials: L
authors.lastname: Belzunces
mesh_terms: D000327:Adsorption; D000818:Animals; D001673:Biodegradation, Environmental; D017173:Caenorhabditis elegans / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000032:analysis / Q000737:chemistry / Q000633:toxicity; D007306:Insecticides / Q000032:analysis / Q000737:chemistry / Q000633:toxicity; D008954:Models, Biological; D010261:Paraoxon / Q000032:analysis / Q000737:chemistry* / Q000633:toxicity*; D010278:Parathion / Q000032:analysis / Q000737:chemistry* / Q000633:toxicity*; D012989:Soil Pollutants / Q000032:analysis / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D012989:Soil Pollutants; D010278:Parathion; D010261:Paraoxon