title: In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma.
abstract: Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
authors.forename: Kyung Ah
authors.initials: KA
authors.lastname: Koo
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Park
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000818:Animals; D032408:Callicarpa; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D018698:Glutamic Acid; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006027:Glycosides; D018696:Neuroprotective Agents; D010936:Plant Extracts; D018698:Glutamic Acid