title: SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD).
abstract: Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]beta-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
authors.affiliation: Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Nussbaumstr. 7, D-80336 Munich, Germany. oliver.pogarell@med.uni-muenchen.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
authors.forename: Gabriele
authors.initials: G
authors.lastname: Poepperl
authors.forename: Christoph
authors.initials: C
authors.lastname: Mulert
authors.forename: Christine
authors.initials: C
authors.lastname: Hamann
authors.forename: Nikolai
authors.initials: N
authors.lastname: Sadowsky
authors.forename: Michael
authors.initials: M
authors.lastname: Riedel
authors.forename: Hans-Juergen
authors.initials: HJ
authors.lastname: Moeller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Klaus
authors.initials: K
authors.lastname: Tatsch
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D015283:Citalopram / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors