title: Familial short fifth metacarpals and insulin resistance.
abstract: Very few reports on the phenotype of short fifth metacarpals have been published in the medical literature. We report a Jordanian family in which three sisters aged 15, 13 and 8 years revealed bilateral shortening of the fifth fingers and radiological shortening of the fifth metacarpals. The father had unilateral short fifth metacarpal. The elder two sisters, their father as well as their brother and another sister manifested insulin resistance. Spherocytosis was diagnosed in one of the girls and her father. The parents are non-consanguineous. This constellation of findings has not been previously reported and could point to the presence of two disorders segregating in the family or to a novel syndrome with autosomal dominant inheritance and variable expressivity.
authors.affiliation: National Center for Diabetes, Endocrinology and Genetics, P.O. Box 13165, 11942 Amman, Jordan.
authors.forename: Muwafag
authors.initials: M
authors.lastname: Hyari
authors.forename: Hanan
authors.initials: H
authors.lastname: Hamamy
authors.forename: Muries
authors.initials: M
authors.lastname: Barham
authors.forename: Azmy
authors.initials: A
authors.lastname: Al-Hadidy
authors.forename: Kamel
authors.initials: K
authors.lastname: Ajlouni
mesh_terms: D002648:Child; D005260:Female; D006228:Hand Deformities, Congenital / Q000000981:diagnostic imaging* / Q000235:genetics*; D006801:Humans; D007333:Insulin Resistance; D050279:Metacarpal Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging; D010375:Pedigree; D011859:Radiography