Synthesis and biodistribution of 2-[123I]iodomelatonin in normal mice.
Melatonin demands that this hormone and its receptors be well understood. With this aim in mind, synthetic melatonin was radioiodinated with no-carrier-added (n.c.a.) sodium iodide-123 using in situ generated peracetic acid as oxidizing agent for electrophilic iodination at room temperature. The radiochemical yield was typically greater than 80% after 20 min reaction time especially when relatively small amounts of activities were used (<or=10 mCi). Biological evaluation was performed in normal mice. The distribution of the tracer did not reveal any specificity during the time frame studied. There was no significant retention in the whole brain.
Al-Jammaz
I
I
Cyclotron and Radiopharmaceuticals Department, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. jammaz@kfshrc.edu.sa
Al-Otaibi
B
B
Aboul-Enein
H
H
Amartey
J K
JK
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D008550:Melatonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051379:Mice; D008808:Mice, Inbred CBA; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; C044556:2-iodomelatonin; D008550:Melatonin