title: [Expression of pituitary tumor transforming gene, endostatin, and basic fibroblast growth factor mRNAs in invasive pituitary adenomas].
abstract: OBJECTIVE
  To investigate the effect of the expression of pituitary tumor transforming gene (PTTG), endostatin and basic fibroblast growth factor (bFGF) in invasive pituitary adenomas.
  
  
  METHODS
  Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of PTTG, endostatin, and bFGF mRNA in invasive and non-invasive pituitary adenomas.
  
  
  RESULTS
  The expression of PTTG and bFGF significantly increased in the invasive pituitary adenomas (all P < 0.01) compared with those in the non-invasive pituitary adenomas. However, the expression of endostatin significantly decreased in the invasive pituitary adenomas compared with the non-invasive pituitary adenomas (P < 0.01).
  
  
  CONCLUSIONS
  Increased expression of human PTTG and bFGF, and decreased expression of endostatin may be related to the genesis of tumor invasiveness. The feasible mechanism may be related to that the increased expression of PTTG plays a role in pituitary tumor invasiveness by altering the balance of tumor angiogenesis.
authors.affiliation: Department of Neurosurgery, Xuanwu Hoaspital, Capital University of Medical Sciences, Beijing 100053. chlyz@sina.com
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Yun-sheng
authors.initials: YS
authors.lastname: Liu
authors.forename: Lu-shen
authors.initials: LS
authors.lastname: Wang
authors.forename: Hai-gui
authors.initials: HG
authors.lastname: Yin
authors.forename: Qing-tian
authors.initials: QT
authors.lastname: Hou
authors.forename: Zhi-xiong
authors.initials: ZX
authors.lastname: Liu
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Ling
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D043169:Endostatins / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D064249:Securin
chemical_list: D043169:Endostatins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human; D016222:Fibroblast Growth Factor 2