title: An indolent case of T-prolymphocytic leukemia with t(3;22)(q21;q11.2) and elevated serum beta2-microglobulin.
abstract: We report a novel case of T-prolymphocytic leukemia, small cell variant, associated with complex cytogenetic findings including t(3;22)(q21;11.2) and elevated serum beta2-microglobulin. The diagnosis is based on morphologic, immunophenotypic, cytogenetic, and molecular analysis of peripheral blood and bone marrow. In contrast to most reported cases of T-prolymphocytic leukemia, this patient did not present with lymphadenopathy or organomegaly. Moreover, only a moderate leukocytosis (25.3 x 10(3)/microL) was evident at presentation. In the absence of any specific treatment, the patient is doing well, with a stable white blood cell count 12 months following presentation. Further investigation may be warranted to determine whether the unusual cytogenetic findings and elevated serum beta2-microglobulin are associated with the indolent clinical course in this patient.
authors.affiliation: Department of Pathology, George Washington University Hospital, Washington, DC 20037, USA.
authors.forename: Farah
authors.initials: F
authors.lastname: Moid
authors.forename: Estella
authors.initials: E
authors.lastname: Day
authors.forename: Marta A
authors.initials: MA
authors.lastname: Schneider
authors.forename: Kenneth
authors.initials: K
authors.lastname: Goldstein
authors.forename: Louis
authors.initials: L
authors.lastname: DePalma
mesh_terms: D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D015463:Leukemia, Prolymphocytic / Q000097:blood / Q000235:genetics / Q000473:pathology; D015461:Leukemia, Prolymphocytic, T-Cell / Q000097:blood / Q000235:genetics / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D001613:beta 2-Microglobulin