Antifungal activity of drimane sesquiterpenes from Drimys brasiliensis using bioassay-guided fractionation.
OBJECTIVE
This study describes the antifungal effect of extracts and compounds isolated from Drimys brasiliensis acting against dermatophytes.


METHODS
The activities were evaluated by using the microbroth dilution method.


RESULTS
Bioassay-guided fractionation of the most active extract from the bark (CHCl3) led to the isolation of the sesquiterpene drimanes polygodial, 1-beta-(p-methoxycinnamoyl)-polygodial, drimanial and 1-beta-(p-cumaroyloxy)-polygodial, which were selectively active against Epidermophyton floccosum and Tricophyton rubrum.


CONCLUSIONS
The selective antifungal activity reported in this paper for drimanes isolated from D. brasiliensis opens the possibility that they could be helpful for the developing of new antifungal agents for treating the difficult to eradicate dermatomycoses produced by E. floccosum.
Malheiros
Angela
A
Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, Itajaí, SC, Brazil. angela@univali.br
Cechinel Filho
Valdir
V
Schmitt
Clarisse B
CB
Yunes
Rosendo A
RA
Escalante
Andrea
A
Svetaz
Laurq
L
Zacchino
Susana
S
Delle Monache
Franco
F
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay / Q000379:methods* / Q000706:statistics & numerical data; D032424:Drimys; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane