Synthesis of the ABCD ring of gambierol.
A fully functionalized ABCD ring moiety of gambierol, a marine polycyclic ether toxin, was synthesized by the use of the oxiranyl anion strategy and reductive cycloetherification of a beta,delta-dihydroxy ketone.
Furuta
Hiroki
H
Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan.
Hase
Mariko
M
Noyori
Ryoji
R
Mori
Yuji
Y
D000818:Animals; D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000737:chemistry; D004141:Dinoflagellida / Q000737:chemistry; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D035964:Oxocins
D002922:Ciguatoxins; D004988:Ethers, Cyclic; D008387:Marine Toxins; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins