Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery.
Particle behavior in the human respiratory tract is well understood and can be used to (1) estimate particle deposition in all regions of the respiratory tract for any aerosol respired at any pattern, and (2) optimize targeting of all regions of the respiratory tract in respiratory drug delivery. Extrathoracic and alveolar regions can effectively be targeted with mono- and polydisperse aerosols respired steadily. Effective targeting of the bronchial region can only be achieved with bolus inhalations. When particles are suspended in a gas heavier than air, targeting the alveolar region can be enhanced.
Heyder
Joachim
J
GSF-National Research Center for Environment and Health, Institute for Inhalation Biology, D-85758 Neuherberg/Munich, Germany. joachim.heyder@gsf.de
D000280:Administration, Inhalation; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D010316:Particle Size; D015656:Respiratory Mechanics / Q000187:drug effects; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*; D019141:Respiratory System Agents / Q000008:administration & dosage*; D012680:Sensitivity and Specificity
D019141:Respiratory System Agents