Drug-resistant malaria.
In the past 21 years, a modest increase in the range of antimalarial drugs approved for clinical use has been complemented by a more impressive expansion in the analysis and understanding of the molecular mechanisms underlying resistance to these agents. Such resistance is a major factor in the increasing difficulty in controlling malaria, and important developments during this period are recounted here.
Hyde
John E
JE
Faculty of Life Sciences, University of Manchester, Jackson's Mill, PO Box 88, Manchester M60 1QD, UK. john.hyde@manchester.ac.uk
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004338:Drug Combinations; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D010961:Plasmodium / Q000187:drug effects* / Q000235:genetics
D000962:Antimalarials; D004338:Drug Combinations