Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives.
As a continuation of our search for potential new anticancer agents, a series of ten flavonoid derivatives has been synthesized by cyclization of substituted chalcones. Target compounds were evaluated for their biological activity. Among them, compounds 1-4 and 9 displayed a significant growth inhibitory action against a panel of tumor cell lines including Jurkat, PC-3, and Colon 205. On treatment with an equitoxic (IC50) concentration, compounds 1-5 and 7-9 blocked cells in the G2/M phase of the Jurkat cell cycle, whereas compound 6 blocked the same in the G0/G1 phase.
Rao
Yerra Koteswara
YK
Institute of Biotechnology, Chaoyang University of Technology, Wufeng 413, Taiwan, ROC.
Fang
Shih-Hua
SH
Tzeng
Yew-Min
YM
D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D015394:Molecular Structure
D005419:Flavonoids