title: Urinary interleukin-8 is elevated in urinary tract infections independently of the causative germs.
abstract: Interleukin-8 elevation in urine during urinary tract infections (UTIs) has been documented for different uropathogenic germs in 85 patients. We showed that for 17 different isolates, IL-8 was increased in 92% of UTIs with an average value of 627 pg/ml for infected, as compared to 45 pg/ml for uninfected patients. We suggest that the high negative predictive value of the IL-8 urine assay could be useful to eliminate UTIs in routine screenings.
authors.affiliation: Laboratoire de Bactériologie, CHU de Nice, France. oregioni.o@chu-nice.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Oregioni
authors.forename: Pascal
authors.initials: P
authors.lastname: Delaunay
authors.forename: Pascal
authors.initials: P
authors.lastname: Bruna
authors.forename: Alice
authors.initials: A
authors.lastname: Gaudart
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Lemichez
authors.forename: Patrice
authors.initials: P
authors.lastname: Boquet
authors.forename: Luce
authors.initials: L
authors.lastname: Landraud
mesh_terms: D000900:Anti-Bacterial Agents; D001424:Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology / Q000652:urine; D006801:Humans; D016209:Interleukin-8 / Q000652:urine*; D009504:Neutrophils; D011237:Predictive Value of Tests; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000382:microbiology / Q000652:urine
chemical_list: D000900:Anti-Bacterial Agents; D016209:Interleukin-8