Alkamides from the leaves of Zanthoxylum syncarpum.
Three alkamides (1-3) were isolated from the leaves of Zanthoxylum syncarpum. The structures of the new compounds 1 and 2 were established by spectroscopic data and chemical conversion, and by the X-ray crystallography of 1. Compound 3, the racemic form of the known compound syncarpamide, showed moderate antiplasmodial activity, with IC50 values of 4.2 and 6.1 microM against Plasmodium falciparum D6 clone and W2 clone, respectively.
Ross
Samir A
SA
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677-1848, USA. sross@olemiss.edu
Al-Azeib
Mounirah A
MA
Krishnaveni
Kesanapalli S
KS
Fronczek
Frank R
FR
Burandt
Charles L
CL
D000818:Animals; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D009638:Norepinephrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D053284:Polyunsaturated Alkamides; D013237:Stereoisomerism; D014687:Venezuela; D032106:Zanthoxylum / Q000737:chemistry*
C504682:3-methoxy-7-acetylaegeline; C504681:3-methoxyaegeline; D001555:Benzene Derivatives; D053284:Polyunsaturated Alkamides; C483277:syncarpamide; D009638:Norepinephrine