title: [Platelet associated immunoglobulin in the pathogenesis of thrombocytopenia in patients with chronic liver disease].
abstract: OBJECTIVE
  To explore the role of platelet associated immunoglobulin (PAIg) in the mechanism of thrombocytopenia associated with chronic liver disease.
  
  
  METHODS
  The levels of PAIg, PAIgG, PAIgA, and PAIgM were detected in 48 viral hepatitis patients with thrombocytopenia, 36 viral hepatitis patients with normal platelet count and 20 healthy subjects by flow cytometry.
  
  
  RESULTS
  PAIg and PAIgG levels (34.54 +/- 14.54%, 28.98 +/- 14.77%, respectively) in the 48 viral hepatitis with thrombocytopenia were significantly higher than those [(21.12 +/- 10.88)%, (16.60 +/- 7.83)%, respectively, P < 0.001)] in the 36 viral hepatitis with normal platelet count and those [(21.15 +/- 16.15) %, (14.89 +/- 9.57)% , respectively, P < 0.01)] in the 20 healthy controls. An inverse correlation was found between the platelet count and PAIg levels (r = -0.446, P < 0.01), and an inverse correlation was also observed between the platelet count and PAIgG levels (r = -0.462, P < 0.01).
  
  
  CONCLUSIONS
  Autoimmune mechanism mediated by PAIg may play an important role in thrombocytopenia associated with viral hepatitis.
authors.affiliation: Department of Infectious Disease,Xiangya Hospital, Central South University, Changsha 410008, China. snakewin65@yahoo.com.cn
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Jiang
authors.forename: Yu-tao
authors.initials: YT
authors.lastname: Xie
authors.forename: De-ming
authors.initials: DM
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000209:etiology / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007136:Immunoglobulins