Validation of the association between the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a Japanese population.
BACKGROUND
Recently, the 5-lipoxygenase activating protein gene (ALOX5AP) was reported to confer a risk of myocardial infarction (MI) and stroke, independent of conventional risk factors. The purpose of the present study was to validate those findings in a Japanese population.


RESULTS
The study population consisted of 1,875 subjects (males 871, females 1,004) recruited from the Suita study (control group) and 353 subjects (males 306, females 47) with MI. The promoter, all of the exons, and 3'UTR regions of ALOX5AP were sequenced in 96 subjects, and 8 polymorphisms were found. There were significant differences in the frequencies of the haplotypes constructed from the 2 SNPs (A162C and T8733A) between the control and MI groups. Multiple logistic analysis indicated that the homozygous genotype of the (CA) haplotype was significantly associated with a reduced risk for MI.


CONCLUSIONS
The hypothesis that ALOX5AP contributes to susceptibility for MI was validated in a Japanese population.
Kajimoto
Kazuaki
K
National Cardiovascular Center, Suita, Japan.
Shioji
Keisuke
K
Ishida
Chisaki
C
Iwanaga
Yoshitaka
Y
Kokubo
Yoshihiro
Y
Tomoike
Hitonobu
H
Miyazaki
Shun-ichi
S
Nonogi
Hiroshi
H
Goto
Yoichi
Y
Iwai
Naoharu
N
D020413:3' Untranslated Regions / Q000235:genetics*; D058927:5-Lipoxygenase-Activating Proteins; D000368:Aged; D044466:Asian People; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
D020413:3' Untranslated Regions; D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D002352:Carrier Proteins; D008565:Membrane Proteins