title: Microbiologic and immunologic evaluation of a single high dose of azithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia.
abstract: We evaluated the efficacy of azithromycin therapy given as a single high dose or divided over 5 days for the treatment of mild experimental Mycoplasma pneumoniae pneumonia. Although both azithromycin regimens significantly reduced quantitative cultures, lung histopathology, and pulmonary cytokines and chemokines, there were no significant differences between the two regimens.
authors.affiliation: Department of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9063, USA.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Ríos
authors.forename: Mónica
authors.initials: M
authors.lastname: Fonseca-Aten
authors.forename: Asunción
authors.initials: A
authors.lastname: Mejías
authors.forename: Susana
authors.initials: S
authors.lastname: Chávez-Bueno
authors.forename: Kathy
authors.initials: K
authors.lastname: Katz
authors.forename: Ana María
authors.initials: AM
authors.lastname: Gómez
authors.forename: George H
authors.initials: GH
authors.lastname: McCracken
authors.forename: Octavio
authors.initials: O
authors.lastname: Ramilo
authors.forename: R Doug
authors.initials: RD
authors.lastname: Hardy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005260:Female; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009177:Mycoplasma pneumoniae; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D018925:Chemokines; D016207:Cytokines; D017963:Azithromycin