title: Isolation of lignans and biological activity studies of Ephedra viridis.
abstract: Phytochemical investigation of Ephedra viridis (whole plant) led to the isolation of four lignans including (+)-9-acetoxyisolariciresinol, which is a new lignan, lariciresinol, 9-acetoxylariciresinol and isolariciresinol. All the isolates were tested for their antioxidant activity and cytotoxicity against a panel of solid tumor and human leukemia cells. They were also screened for estrogenic activity using a recombinant yeast estrogen screening (YES) assay. Most of the lignans exhibited moderate antioxidant activity without any cytotoxicity. None of them were estrogenic in the YES assay.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, 38677, USA.
authors.forename: Srinivas V
authors.initials: SV
authors.lastname: Pullela
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D029789:Ephedra; D004967:Estrogens / Q000096:biosynthesis; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004967:Estrogens; D017705:Lignans; D010936:Plant Extracts