title: The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice.
abstract: We have previously shown that intraperitoneal vaccination with the recombinant N terminus of Als1p (rAls1p-N) modestly improves survival during murine disseminated candidiasis. We now report marked efficacy with subcutaneous rAls1p-N vaccination. Efficacy is retained in neutropenic and corticosteroid-treated mice. The rAls1p-N vaccine is a promising candidate for the prevention of invasive candidiasis.
authors.affiliation: Division of Infectious Diseases, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA. bspellberg@labiomed.org
authors.forename: Brad J
authors.initials: BJ
authors.lastname: Spellberg
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Ibrahim
authors.forename: Valentina
authors.initials: V
authors.lastname: Avenissian
authors.forename: Scott G
authors.initials: SG
authors.lastname: Filler
authors.forename: Carter L
authors.initials: CL
authors.lastname: Myers
authors.forename: Yue
authors.initials: Y
authors.lastname: Fu
authors.forename: John E
authors.initials: JE
authors.lastname: Edwards
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000235:genetics / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control*; D005656:Fungal Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D005657:Fungal Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010446:Peptide Fragments / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: C093538:ALS1 protein, Candida albicans; D005656:Fungal Proteins; D005657:Fungal Vaccines; D010446:Peptide Fragments; D014614:Vaccines, Synthetic