Antifungal activity of artemisinin derivatives.
A series of 29 artemisinin derivatives (2-30), including four new compounds (16-18, 20), together with artemisinin (1), artemisinic acid (31), and arteannuin B (32), were tested for antifungal activity against two opportunistic pathogens, Candida albicans and Cryptoccocus neoformans. Of all the compounds tested, anhydrodihydro-artemisinin (3) demonstrated more potent antifungal activity against C. neoformans than amphotericin B. Also, beta-arteether (7) and alpha-arteether (8) showed marked activity against C. neoformans. Against C. albicans, the overall antifungal effect of these compounds was weak or negligible. Derivatives 2-30 were prepared according to literature procedures.
Galal
Ahmed M
AM
College of Pharmacy, Cairo University, Kasr El-Eini Street, 11562, Cairo, Egypt. amgalalv@yahoo.com
Ross
Samir A
SA
Jacob
Melissa
M
ElSohly
Mahmoud A
MA
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D020650:Combinatorial Chemistry Techniques; D003455:Cryptococcus neoformans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000935:Antifungal Agents; D037621:Artemisinins