title: Sclerosing panniculitis is associated with pulmonary hypertension in systemic sclerosis.
abstract: BACKGROUND
  There have been no reports of patients with sclerosing panniculitis and systemic sclerosis (SSc).
  
  
  OBJECTIVE
  To evaluate the incidence of sclerosing panniculitis in patients with SSc, and to investigate the clinical features of such cases.
  
  
  METHODS
  In total, 128 patients with SSc treated at our clinic were investigated retrospectively.
  
  
  RESULTS
  SSc patients with sclerosing panniculitis had pulmonary hypertension (PH), especially isolated PH, at a significantly higher incidence than those without. Among the SSc patients with PH, those with sclerosing panniculitis had pulmonary infarctions at a higher incidence than those without.
  
  
  CONCLUSIONS
  Our results suggest that thrombosis caused by venous hypertension of the leg may be the main cause of PH in patients with SSc and sclerosing panniculitis. Sclerosing panniculitis may be a useful marker of PH in patients with SSc.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Jinnin
authors.forename: H
authors.initials: H
authors.lastname: Ihn
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: K
authors.initials: K
authors.lastname: Yamane
authors.forename: N
authors.initials: N
authors.lastname: Yazawa
authors.forename: K
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D004452:Echocardiography; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000000981:diagnostic imaging; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015434:Panniculitis / Q000150:complications* / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000150:complications / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000150:complications* / Q000000981:diagnostic imaging; D018709:Statistics, Nonparametric
chemical_list: D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid