title: [Genetic aspects of malignant epithelial ovarian tumours].
abstract: OBJECTIVE
  To sum up the knowledge about genetic aspects of ovarian cancer.
  
  
  METHODS
  Review article.
  
  
  METHODS
  Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University Prague and General Teaching Hospital Prague, Prague.
  
  
  METHODS
  Compilation of data from scientific literature.
  
  
  CONCLUSIONS
  Ovarian cancer represents the most lethal malignancy among gynecological tumours. Etiology is still largely unknown. Multistep process, with accumulation of genetic alterations concerning factors with key role in cell regulation - oncogenes, tumor-supressor genes and mismatch-repair genes is supposed. Cytogenetic and molecular-genetic characteristics, in correlation with other molecular-biological parameters extend information of carcinogenesis. The final aim is to create a predictive model for clinical use.
authors.affiliation: Gynekologicko-porodnicki klinika 1. LF UK a VFN, Praha.
authors.forename: N
authors.initials: N
authors.lastname: Jancárková
authors.forename: M
authors.initials: M
authors.lastname: Krkavcová
authors.forename: M
authors.initials: M
authors.lastname: Janashia
authors.forename: P
authors.initials: P
authors.lastname: Freitag
mesh_terms: D002277:Carcinoma / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D016147:Genes, Tumor Suppressor; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes / Q000235:genetics