title: Synthesis of melanin pigment by Candida albicans in vitro and during infection.
abstract: Melanins are implicated in the pathogenesis of several important human diseases. This study confirmed the presence of melanin particles in Candida albicans in vitro and during infection. Dark particles were isolated from the digestion of C. albicans cultures and from infected tissue, as established by electron microscopy and immunofluorescence techniques.
authors.affiliation: St. John's Institute of Dermatology, St. Thomas' Hospital, London SE1 9RT, United Kingdom. themojos@boltblue.com
authors.forename: Rachael
authors.initials: R
authors.lastname: Morris-Jones
authors.forename: Beatriz L
authors.initials: BL
authors.lastname: Gomez
authors.forename: Soraya
authors.initials: S
authors.lastname: Diez
authors.forename: Martha
authors.initials: M
authors.lastname: Uran
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Morris-Jones
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000378:metabolism* / Q000472:pathogenicity / Q000648:ultrastructure; D002177:Candidiasis / Q000378:metabolism* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D008297:Male; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D014774:Virulence
chemical_list: D008543:Melanins