The effect of Chinese herbs on the cytokines of rats with endometriosis.
OBJECTIVE
The aim of this study was to study the regulatory function of Chinese medicine-YiWeiNing (YWN) on the cytokines of endometriosis (EM) model rats.


METHODS
After successfully creating EM models of rats, all were separated randomly into five groups: high dose of YWN (5.4 g/100 g), low dose of YWN (1.8 g/100 g), Danazol group (3.6 mg/100 g), a model group, and a false-operation group. They were then reviewed for the variation of the amount of TNF-alpha (tumor necrosis factor-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8).


RESULTS
The content of TNF-alpha, IL-6, and IL-8 in the peripheral blood of the model group was apparently higher than the false-operation group (p < 0.01), and YWN reduced the amount of TNF-alpha, IL-6, and IL-8 in the serums of the model group's rats. This made these cytokines tend toward normal levels without an apparent variation, when compared with the false-operation group (p > 0.05).


CONCLUSIONS
YWN can prevent the growth of ectopic endometrium by inhibiting the synthesis and secretion of TNF-alpha, IL-6, and IL-8.
Qu
Fan
F
Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China. qufan43@yahoo.com.cn
Zhou
Jue
J
Ma
Baozhang
B
D000818:Animals; D016207:Cytokines / Q000187:drug effects* / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004715:Endometriosis / Q000188:drug therapy* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D023421:Models, Animal; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha