title: Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women.
abstract: In humans, dehydroepiandrosterone (DHEAS) has been postulated to have anabolic and lipolytic properties that could potentially counteract the catabolic effect of cortisol. DHEAS secretion is reduced in morbid obesity, likely due to hyperinsulinemia, and laparoscopic adjustable gastric banding (LASGB), by inducing considerable and rapid weight loss, reduces insulin levels. To investigate the role of decreased insulin levels after LASGB-induced weight loss on DHEAS levels and on body composition changes, we studied 30 pre-menopausal morbidly obese women (BMI ranging 37-62 kg/m2) before, 6, 12 and 24 months after LASGB. Total body water (TBW), fat-free mass (FFM) and fat mass (FM) were measured by bioelectrical impedance analysis; tissue hydration was also assessed by impedance vector analysis. At study ending, the subjects had a total weight loss of 28% of baseline body weight (15% after 6 months). After LASGB, weight loss was mainly due to decreased FM, and TBW, FFM, and body hydration were not significantly reduced. Weight loss was associated with an 82% rise in serum DHEAS already after 6 months while cortisol, cortisol/DHEAS molar ratio, and insulin levels fell by 5.5, 62 and 50%, respectively, after 6, 12 and 24 months (p<0.05).
  
  
  CONCLUSIONS
  LASGB associated with a well balanced low-calorie diet permits a satisfactory 2-yr weight loss, sparing FFM and without body fluid alterations. As the result of a stable weight reduction program weight loss is associated to decrease in cortisol, cortisol/DHEAS molar ratio, and insulin plasma levels with marked rise in DHEAS. Higher cortisol/DHEAS molar ratio values at baseline are also associated to lower weight loss after LASGB, with lower decrease in FM and higher reduction in FFM and body cell mass, in spite of no differences in dietary regimes. Cortisol/DHEAS molar ratio is likely to represent a reliable marker of favourable modifications in body composition.
authors.affiliation: Endocrinology Unit, Department of Molecular and Clinical Endocrinology and Oncology, Frederico II University, Naples, Italy. sisavast@unina.it
authors.forename: S
authors.initials: S
authors.lastname: Savastano
authors.forename: A
authors.initials: A
authors.lastname: Belfiore
authors.forename: B
authors.initials: B
authors.lastname: Guida
authors.forename: L
authors.initials: L
authors.lastname: Angrisani
authors.forename: F
authors.initials: F
authors.lastname: Orio
authors.forename: T
authors.initials: T
authors.lastname: Cascella
authors.forename: F
authors.initials: F
authors.lastname: Milone
authors.forename: F
authors.initials: F
authors.lastname: Micanti
authors.forename: G
authors.initials: G
authors.lastname: Saldalamacchia
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
authors.forename: A
authors.initials: A
authors.lastname: Colao
mesh_terms: D000328:Adult; D001823:Body Composition / Q000502:physiology*; D001834:Body Water / Q000502:physiology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D015930:Diet Records; D017097:Electric Impedance; D005260:Female; D015391:Gastroplasty; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D010535:Laparoscopy; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology / Q000601:surgery*; D017697:Premenopause; D011795:Surveys and Questionnaires; D013997:Time Factors; D015431:Weight Loss
chemical_list: D007328:Insulin; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone