[Cryopreservation of immature testicular tissue].
An increased incidence of cancer is observed in the population of adolescents and young adults since thirty years. Major progress in cancer diagnosis and therapy is unfortunately associated to high degree of toxicity on gonad function. Cryopreservation of ovarian tissue is performed in girls and women before cancer treatment with high risk of infertility. Procedures for ejaculated or testicular extracted spermatozoa are well defined. However, for prepubertal boys or after ejaculated sperm collection failure, mature or immature testicular tissue banking should be proposed. Still, an optimal cryopreservation protocol is a prerequisite for clinical application and does not exist for the moment. Furthermore, the future applications of immature testicular tissue banking should be developed, not solely germ cell in vitro maturation but also autologous testicular tissue grafting.
Rives
N
N
Laboratoire de biologie de la reproduction-CECOS, CHU Charles-Nicolle, 76031 Rouen cedex, France. nathalie.rives@chu-rouen.fr
Milazzo
J-P
JP
Vaudreuil
L
L
Macé
B
B
D000818:Animals; D015925:Cryopreservation; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D011627:Puberty; D013094:Spermatozoa / Q000502:physiology; D013737:Testis / Q000254:growth & development / Q000637:transplantation