title: Antimicrobial susceptibilities of Austrian Francisella tularensis holarctica biovar II strains.
abstract: The antibiotic susceptibilities of 50 Francisella tularensis subsp. holarctica biovar II strains isolated from hares and human patients from the eastern part of Austria were examined. Minimum inhibitory concentrations (MICs) of 24 antimicrobial agents were determined using Eteststrade mark on cysteine heart agar plates supplemented with 10% sheep blood. All isolates were sensitive to tetracyclines, aminoglycosides, quinolones, chloramphenicol and rifampicin. Resistance was observed in all isolates against macrolides, penicillins and aztreonam. Bacteria were resistant to cephalosporins and carbapenems, except for 8% of strains investigated that were susceptible or intermediately susceptible. Our in vitro susceptibility data can be applied for the detection and comparison of resistance development and to provide in vitro data for the guidance of therapy.
authors.affiliation: Bundeswehr Institute of Microbiology, Munich, Germany. herberttomaso@bundeswehr.org
authors.forename: Herbert
authors.initials: H
authors.lastname: Tomaso
authors.forename: Sascha
authors.initials: S
authors.lastname: Al Dahouk
authors.forename: Erwin
authors.initials: E
authors.lastname: Hofer
authors.forename: Wolf D
authors.initials: WD
authors.lastname: Splettstoesser
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Treu
authors.forename: Manfred P
authors.initials: MP
authors.lastname: Dierich
authors.forename: Heinrich
authors.initials: H
authors.lastname: Neubauer
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D001317:Austria; D015780:Carbapenems / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D005604:Francisella tularensis / Q000187:drug effects*; D034621:Hares / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014406:Tularemia / Q000382:microbiology*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D015780:Carbapenems; D002511:Cephalosporins; D015363:Quinolones; D002701:Chloramphenicol; D013752:Tetracycline; D012293:Rifampin