Spontaneous major bleeding in acquired factor X deficiency secondary to AL-amyloidosis.
Abnormal bleeding may be seen in up to a third of patients with amyloidosis. Factor X deficiency is the commonest acquired coagulopathy in amyloidosis. While mild intracutaneous bleeding is common, spontaneous life-threatening haemorrhage is rare. We report a case of acquired FX deficiency due to amyloid light chain (AL)-amyloidosis presenting with spontaneous retroperitoneal bleeding. The diagnostic and management issues in this patient are discussed.
Enjeti
A K
AK
Department of Haematology, Newcastle Mater Misericordiae Hospital, NSW, Australia. anoopenjeti@yahoo.co.in
Walsh
M
M
Seldon
M
M
D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000150:complications*; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D005171:Factor X Deficiency / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D012187:Retroperitoneal Space
D001779:Blood Coagulation Factors; C025667:prothrombin complex concentrates