title: Hyperammonaemia in a child with distal renal tubular acidosis.
abstract: A 5-month-old girl with distal renal tubular acidosis (RTA) and hyperammonaemia that had lasted for 12 days, despite metabolic acidosis correction, is presented in this report. The patient showed failure to thrive, poor feeding, hypotonia and vomiting crisis in absence of inborn errors of metabolism. Probably, hyperammonaemia was the result of an imbalance between the increased ammonia synthesis, in response to metabolic acidosis, and the impaired ammonia excretion, typical of distal RTA. Our case confirms that hyperammonaemia may be observed in distal RTA, mimicking an inborn error of metabolism, and it underlines that hyperammonaemia may persist several days after metabolic acidosis correction.
authors.affiliation: Paediatric Nephrology, Department of Paediatrics, University of Florence, via Luca Giordano 13, 50132 Florence, Italy. d.seracini@meyer.it
authors.forename: D
authors.initials: D
authors.lastname: Seracini
authors.forename: G M
authors.initials: GM
authors.lastname: Poggi
authors.forename: I
authors.initials: I
authors.lastname: Pela
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D022124:Hyperammonemia / Q000150:complications* / Q000628:therapy; D007223:Infant