title: Direct percutaneous coronary intervention for NSTEMI in a patient with seropositive Wegener's granulomatosis.
abstract: A case of a 49-year-old man who presented with symptoms of generalized classical Wegener's granulomatosis with the exceptional complication of acute non-ST-elevation myocardial infarction (NSTEMI) is reported. Coronary arteriography revealed an extensive arteritis with multi-local stenosis of the left anterior descending coronary artery. The culprit lesion was treated by stent implantation with success while immunosuppressive treatment with cyclophosphamide and prednisolone was continued. Using arteriography, 4 months later we found normal coronary arteries without manifestation of vasculitis. Within 8 months of medical treatment complete remission was achieved and therapy was changed to low-dose methotrexate once a week. Meanwhile medical treatment has been stopped entirely. The patient is in good clinical condition. This case indicates that the adverse event of coronary vasculitis in any patient suffering from primary or secondary vasculitis can occur. Clinically significant myocardial ischemia can occur and can even lead to myocardial infarction.
authors.affiliation: Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Karl-Olga-Krankenhaus GmbH, Hackstr. 61, 70190 Stuttgart, Germany. Georg.Schmidt@Karl-Olga-Krankenhaus.de
authors.forename: G
authors.initials: G
authors.lastname: Schmidt
authors.forename: R
authors.initials: R
authors.lastname: Gareis
authors.forename: T
authors.initials: T
authors.lastname: Störk
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D023921:Coronary Stenosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004338:Drug Combinations; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone