title: Results of total gastrectomy with extended lymphadenectomy for gastric cancer in elderly patients.
abstract: OBJECTIVE
  The incidence of gastric cancer, in people over 70 years of age, has increased remarkably. Aggressive lymphadenectomy with gastrectomy has been reported to improve survival in patients with gastric cancer. Because complication rates following gastrectomy increase with advancing age, we sought to determine whether this procedure was merited in elderly patients with gastric cancer.
  
  
  METHODS
  We performed a retrospective analysis of 202 patients who underwent total gastrectomy with extended lymphadenectomy for gastric carcinoma. Postoperative complication rates were compared between patients over and under 70 years of age.
  
  
  RESULTS
  The 10-year survival rates of patients under and over 70 years of age following total gastrectomy with extended lymphadenectomy were not significantly different. Although medical comorbidities in each group were similar, pulmonary dysfunction was significantly more common following total gastrectomy in patients over 70 years than in patients under 70 years. Moreover, logistic regression analysis revealed that patient's age was the only variable that independently correlated with the presence of postoperative complications.
  
  
  CONCLUSIONS
  The prognosis of the gastric cancer patients over 70 years of age was similar to that of younger patients after total gastrectomy with extensive lymphadenectomy. However, pulmonary dysfunction was significantly more common in patients over 70 years old.
authors.affiliation: Department of Surgery, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji Kamigyo-ku, Kyoto, Japan. otsuji@koto.kpu-m.ac.jp
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
authors.forename: Junshin
authors.initials: J
authors.lastname: Fujiyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takagi
authors.forename: Tadao
authors.initials: T
authors.lastname: Ito
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toma
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Akeo
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D015897:Comorbidity; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis