title: Selective serotonin reuptake inhibitors treatment effects on auditory measures in depressed female subjects.
abstract: The purpose of this study was to evaluate the auditory effects of selective serotonin reuptake inhibitors (SSRI), known to enhance serotonin (5-HT) transmission in the brain. The experimental group consisted of 14 clinically depressed female subjects, and the control group consisted of 11 non-depressed females. A battery of tests was administered to the experimental group while on and off of SSRI medication. The control group was also administered the test battery twice. Results indicated no significant differences in the control group between sessions. The experimental group showed significantly smaller transient evoked emissions, higher SCAN-A (auditory processing test) composite scores, and smaller amplitude growth functions for Auditory brainstem response peak V and Auditory late response peak N(1)P(2) while on SSRI medication. The increased 5-HT levels in the presence of SSRI (due to reduced reuptake of 5-HT) may be contributing to the significant changes seen in auditory measures with the experimental group.
authors.affiliation: Department of Speech and Hearing Sciences, University of North Texas, P.O. Box 305010, Denton, TX 76203, Texas, USA. gopal@unt.edu
authors.forename: Kamakshi V
authors.initials: KV
authors.lastname: Gopal
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Briley
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Goodale
authors.forename: Oana M
authors.initials: OM
authors.lastname: Hendea
mesh_terms: D000158:Acoustic Impedance Tests; D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003863:Depression / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004007:Dichotic Listening Tests; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008144:Loudness Perception / Q000187:drug effects; D017374:Paroxetine / Q000627:therapeutic use*; D012701:Serotonin / Q000097:blood / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D013067:Speech Perception / Q000187:drug effects
chemical_list: D005473:Fluoxetine; D017374:Paroxetine; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline