title: Papillomavirus infection in the conjunctiva of individuals with and without AIDS: an autopsy series from Uganda.
abstract: HIV and genus beta human papillomavirus (HPV) types have been associated with squamous cell carcinoma of the conjunctiva (SCC). To determine whether conjunctival HPV infection is associated with AIDS, we analysed 136 lesion-free eye biopsies and tested for genera alpha, beta and gamma HPV types. Only infections with genera beta and gamma HPV types was found. After adjustment for age and gender, no excess of genera beta or gamma HPV infection was found in individuals who had died of or with AIDS compared to those who had died of other infectious diseases [relative risk (RR)=1.3; 95% confidence interval (CI): 0.4-4.8], or chronic diseases or trauma (RR=0.9; 95% CI: 0.3-2.9). Our findings suggest that infection with genera beta or gamma HPV types in lesion-free conjunctivas is common, but not greatly enhanced by the presence of AIDS.
authors.affiliation: Makerere University Medical School, P.O. Box 7072, Kampala, Uganda.
authors.forename: Charles
authors.initials: C
authors.lastname: Ateenyi-Agaba
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
authors.forename: Massimo
authors.initials: M
authors.lastname: Tommasino
authors.forename: Anouk
authors.initials: A
authors.lastname: Smet
authors.forename: Annie
authors.initials: A
authors.lastname: Arslan
authors.forename: Min
authors.initials: M
authors.lastname: Dai
authors.forename: Edward
authors.initials: E
authors.lastname: Katongole-Mbidde
authors.forename: Pierre
authors.initials: P
authors.lastname: Hainaut
authors.forename: Peter J F
authors.initials: PJ
authors.lastname: Snijders
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000821:virology*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D016022:Case-Control Studies; D003230:Conjunctival Neoplasms / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006678:HIV / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D014454:Uganda / Q000453:epidemiology
chemical_list: D004279:DNA, Viral