title: Covalent intermediates and enzyme proficiency.
abstract: Large enzyme efficiencies are due to small rate constants for the reaction in water, not to the formation of covalent intermediates.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. tcbruice@chem.ucsb.edu
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Bruice
authors.forename: Paula Yurkanis
authors.initials: PY
authors.lastname: Bruice
mesh_terms: D000577:Amides / Q000737:chemistry; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry*; D004950:Esterases / Q000737:chemistry; D015394:Molecular Structure; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D004798:Enzymes; D014867:Water; D004950:Esterases