title: Expression of beta-catenin, p63 and CD34 in hair follicles during the course of androgenetic alopecia.
abstract: During the hair growth cycle, the hair follicle appears to recapitulate part of its embryogenesis where both beta-catenin and p63 participate. The aim of the present study was to investigate the hypothesis that beta-catenin and p63 protein may be involved in the pathogenesis of androgenetic alopecia. Second, expression of CD34 protein was used to assess the capillary density of the affected skin. Cadavers were used as samples and the results showed that analysis of beta-catenin, p63 and CD34 expressions in human cadaverous scalp skin by immunohistochemical techniques were possible. We detected a higher expression of p63 in occipital skin in comparison to the affected frontal areas. However, we found only minimal changes in beta-catenin expression comparing frontal and occipital areas. A completely new finding was the expression of CD34 positive cells in the outer root sheath of hair follicles.
authors.affiliation: Institute of Pathology & Laboratory of Molecular Pathology, Faculty of Medicine Palacky University and Faculty Hospital, Hnevotinska 3, Olomouc, 775 15 Czech Republic. mfiuraskova@seznam.cz
authors.forename: Michala
authors.initials: M
authors.lastname: Fiuraskova
authors.forename: Svetlana
authors.initials: S
authors.lastname: Brychtova
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Kolar
authors.forename: Renata
authors.initials: R
authors.lastname: Kucerova
authors.forename: Martina
authors.initials: M
authors.lastname: Bienova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000505:Alopecia / Q000378:metabolism* / Q000473:pathology; D018952:Antigens, CD34 / Q000378:metabolism*; D005786:Gene Expression Regulation; D018859:Hair Follicle / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34; C081876:CKAP4 protein, human; D008565:Membrane Proteins; D051176:beta Catenin