Nucleoside/nucleotide backbones for the treatment of HIV infection.
Nucleoside/nucleotide analogs (NAs) are essential components of most current antiretroviral regimens. Although many dual NA combinations may be used as backbones, not all display optimal results. For instance, some associations should be avoided due to antagonism (eg, zidovudine plus stavudine), high rates of toxicity (eg, didanosine plus stavudine) and/or increased risk of virological failure (eg, didanosine plus tenofovir). Moreover, the knowledge of plasma and intracellular interactions between different NAs is important for choosing appropriate combinations and optimal doses in order to optimize antiviral efficacy and minimize toxicities.
Barreiro
Pablo
P
Service of Infectious Diseases and Service of Pharmacy, Hospital Carlos III, Madrid 28029, Spain.
Jiménez-Nácher
Inmaculada
I
García
Benito
B
García-Benayas
Teresa
T
Rivas
Pablo
P
Soriano
Vincent
V
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D009705:Nucleosides / Q000737:chemistry* / Q000627:therapeutic use*; D009711:Nucleotides / Q000737:chemistry* / Q000627:therapeutic use*
D019380:Anti-HIV Agents; D009705:Nucleosides; D009711:Nucleotides