title: Chronic morphine exposure induces degradation of receptive field properties of LGN cells in cats.
abstract: OBJECTIVE
  To investigate the effect of chronic morphine exposure on the receptive field properties of lateral geniculate nucleus (LGN) neurons in cats.
  
  
  METHODS
  Cats were injected with morphine (10 mg/kg) or saline twice daily, for 10 d. Subsequently, extracellular single-unit recording techniques were used to examine the sensitivity of LGN neurons to visual stimuli in chronic morphine-treated and saline-treated cats.
  
  
  RESULTS
  Compared with saline-treated cats (as controls), LGN neurons in morphine-treated cats had decreased signal-to-noise ratios (1.9 vs 3.1), and orientation and direction sensitivity (0.103 vs 0.135 and 0.074 vs 0.10, respectively), accompanied by significant increases in spontaneous (27.4 vs 17.5) and evoked activity (preferred: 42.2 vs 38.1; average: 28.1 vs 22.3).
  
  
  CONCLUSIONS
  Chronic morphine exposure can lead to the functional degradation of LGN neurons in cats, which might result from the effects of chronic morphine exposure on inhibitory neurotransmission.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Li-hua
authors.initials: LH
authors.lastname: He
authors.forename: Guang-xing
authors.initials: GX
authors.lastname: Li
authors.forename: Xiang-rui
authors.initials: XR
authors.lastname: Li
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Zhou
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D005829:Geniculate Bodies / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009294:Narcotics / Q000008:administration & dosage / Q000009:adverse effects*; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009949:Orientation / Q000187:drug effects*; D010775:Photic Stimulation
chemical_list: D009294:Narcotics; D009020:Morphine