title: A case of non-specific interstitial pneumonia effectively treated with a combination of prednisolone and colchicine, in which granulation tissue was extensive.
abstract: A 56-year-old woman was admitted for interstitial pneumonia, and subsequently diagnosed with idiopathic non-specific interstitial pneumonia with a bronchiolitis obliterans organizing pneumonia pattern, on the basis of clinical and surgical lung biopsy findings. Histological findings revealed diffuse thickness of alveolar walls accompanied by lymphocyte infiltration and fibrosis in the lobules. In addition to those findings, granulation tissue was extensive. Although initial symptom and CT improvement occurred following high-dose prednisolone therapy, the CT did not show further improvement and her serum KL-6 level began increasing again as prednisolone was reduced. With the addition of colchicine therapy, clinical and CT findings improved remarkably and a further reduction of the prednisolone dose was achieved. This case suggests that the combination of colchicine and corticosteroids may be an effective therapy for non-specific interstitial pneumonia.
authors.affiliation: Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan. tamotsui@showa.gunma-u.ac.jp
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hisada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Monden
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Tsunekawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Iizuka
authors.forename: Hideo
authors.initials: H
authors.lastname: Tsukagoshi
authors.forename: Kunio
authors.initials: K
authors.lastname: Dobashi
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003078:Colchicine / Q000008:administration & dosage*; D003094:Collagen / Q000037:antagonists & inhibitors*; D004359:Drug Therapy, Combination; D005260:Female; D006097:Granulation Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D011859:Radiography
chemical_list: D000893:Anti-Inflammatory Agents; D003094:Collagen; D011239:Prednisolone; D003078:Colchicine