The drug sensitivities of Plasmodium falciparum in the Sonitpur district, Assam, India.
Falciparum malaria is an ongoing problem in the foothills of Northeast India. Evaluation of the drug sensitivities of P. falciparum was carried out in four endemic villages of the Sonitpur District of Assam, involving 218 cases who were tested in vivo over 35 days. Chloroquine resistance was detected at the RI level in 29 cases (13%) and RII level in 8 cases (4%). No RIII chloroquine resistant cases were detected in the study. RI resistance was observed in the age groups 6-10 years, 11-14 years, and 15 years and above in 16%, 17%, and 13%, respectively. RII level resistance was observed in 4% of all those groups combined. All the RI and RII resistant cases responded well to a single dosage of Metakelfin (sulfamethoxypyrazine I.P 1,500 mg and pyrimethamine I.P 75 mg).
Baruah
I
I
Medical Entomology Division, Defence Research Laboratory, Tezpur, Assam PIN- 784001, India. indrabaruah@yahoo.com
Talukdar
P K
PK
Das
S C
SC
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D004351:Drug Resistance; D019353:Endemic Diseases; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use; D012424:Rural Population; D013415:Sulfalene / Q000627:therapeutic use
D000962:Antimalarials; D004338:Drug Combinations; C050416:metakelfin; D002738:Chloroquine; D013415:Sulfalene; D011739:Pyrimethamine