title: Complementary detection of prostate-specific antigen using In2O3 nanowires and carbon nanotubes.
abstract: We report complementary detection of prostate-specific antigen (PSA) using n-type In2O3 nanowires and p-type carbon nanotubes. Our innovation involves developing an approach to covalently attach antibodies to In2O3 NW surfaces via the onsite surface synthesis of phosphonic acid-succinylimide ester. Electronic measurements under dry conditions revealed complementary response for In2O3 NW and SWNT devices after the binding of PSA. Real-time detection in solution has also been demonstrated for PSA down to 5 ng/mL, a benchmark concentration significant for clinical diagnosis of prostate cancer, which is the most frequently diagnosed cancer.
authors.affiliation: Department of Electrical Engineering, University of Southern California, Los Angeles, California 90089, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Marco
authors.initials: M
authors.lastname: Curreli
authors.forename: Henry
authors.initials: H
authors.lastname: Lin
authors.forename: Bo
authors.initials: B
authors.lastname: Lei
authors.forename: F N
authors.initials: FN
authors.lastname: Ishikawa
authors.forename: Ram
authors.initials: R
authors.lastname: Datar
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Cote
authors.forename: Mark E
authors.initials: ME
authors.lastname: Thompson
authors.forename: Chongwu
authors.initials: C
authors.lastname: Zhou
mesh_terms: D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D043942:Nanotubes / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D017430:Prostate-Specific Antigen / Q000032:analysis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013997:Time Factors
chemical_list: D037742:Nanotubes, Carbon; D007204:Indium; C047711:indium oxide; D017430:Prostate-Specific Antigen