title: Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.
abstract: Structures are proposed, based on LC-ion trap MSn analysis and high-resolution FTICR MS/MS analysis, for a novel family of mycolactone toxins isolated from the frog pathogen MU128FXT and differing from those produced by the human pathogen M. ulcerans MUAgy99 in having an altered polyketide side chain.
authors.affiliation: Departments of Chemistry and Biochemistry, University of Cambridge, Cambridge, UK.
authors.forename: Hui
authors.initials: H
authors.lastname: Hong
authors.forename: Tim
authors.initials: T
authors.lastname: Stinear
authors.forename: Paul
authors.initials: P
authors.lastname: Skelton
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Spencer
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry*; D002853:Chromatography, Liquid; D003903:Deuterium / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry*; D013058:Mass Spectrometry; D009161:Mycobacterium / Q000737:chemistry*; D009164:Mycobacterium Infections / Q000382:microbiology*; D021241:Spectrometry, Mass, Electrospray Ionization; D014981:Xenopus / Q000382:microbiology*
chemical_list: D001427:Bacterial Toxins; D007783:Lactones; D003903:Deuterium