title: Bronchial hyperresponsiveness in irritable bowel syndrome.
abstract: Extraintestinal symptoms are often found in patients with irritable bowel syndrome (IBS). Recent studies suggest that IBS is associated with bronchial hyperresponsiveness. But it is still arguable that the bronchial hyperresponsiveness is associated with IBS patients. The purpose of this study is to investigate the possible relationship between IBS and bronchial hyperresponsiveness. Forty-two patients with IBS and 42 control subjects were included in this study. All patients underwent pulmonary function, methacholine challenge, and skin prick tests. There was no statistical difference between the two groups with respect to percentage of all pulmonary function test parameters, including FEV(1)%, FCV%, FVC/FEV(1), and FEF(25 - 75)%. Only two persons in the alternating-type IBS patient group and one person in the control group tested positive in the methacholine provocation test. But all PC(20) values were above 16 mg/ml. These results do not demonstrate a relationship between bronchial hyperresponsiveness and IBS. However, a relationship might exist in a subpopulation of IBS patients.
authors.affiliation: Divisions of Gastroenterology, Hanyang University School of Medicine, Seoul, South Korea.
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Jun
authors.forename: Oh Young
authors.initials: OY
authors.lastname: Lee
authors.forename: Ho Joo
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Hang Lak
authors.initials: HL
authors.lastname: Lee
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Yoon
authors.forename: Ho Soon
authors.initials: HS
authors.lastname: Choi
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Dong Hoo
authors.initials: DH
authors.lastname: Lee
authors.forename: Choon Suhk
authors.initials: CS
authors.lastname: Kee
mesh_terms: D000328:Adult; D016535:Bronchial Hyperreactivity / Q000209:etiology* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications*; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage / Q000494:pharmacology; D008875:Middle Aged; D012129:Respiratory Function Tests
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride