[Genetic aspects of malignant epithelial ovarian tumours].
OBJECTIVE
To sum up the knowledge about genetic aspects of ovarian cancer.


METHODS
Review article.


METHODS
Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University Prague and General Teaching Hospital Prague, Prague.


METHODS
Compilation of data from scientific literature.


CONCLUSIONS
Ovarian cancer represents the most lethal malignancy among gynecological tumours. Etiology is still largely unknown. Multistep process, with accumulation of genetic alterations concerning factors with key role in cell regulation - oncogenes, tumor-supressor genes and mismatch-repair genes is supposed. Cytogenetic and molecular-genetic characteristics, in correlation with other molecular-biological parameters extend information of carcinogenesis. The final aim is to create a predictive model for clinical use.
Jancárková
N
N
Gynekologicko-porodnicki klinika 1. LF UK a VFN, Praha.
Krkavcová
M
M
Janashia
M
M
Freitag
P
P
D002277:Carcinoma / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D016147:Genes, Tumor Suppressor; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes / Q000235:genetics