A Place for RNAi.
Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting protein that appears to promote the assembly of P bodies in C. elegans (Ding et al., 2005).
Anderson
Paul
P
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000378:metabolism; D022083:Cytoplasmic Structures / Q000378:metabolism; D020868:Gene Silencing; D034622:RNA Interference / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism
D012333:RNA, Messenger