title: Relationship of lipoprotein lipase and hepatic triacylglycerol lipase activity to serum adiponectin levels in Japanese hyperlipidemic men.
abstract: OBJECTIVE
  The aim of this study was to determine how lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (HTGL) activity relate to serum adiponectin levels.
  
  
  METHODS
  Fifty-five hyperlipidemic Japanese men were recruited for this study. LPL and HTGL activity in post-heparin plasma (PHP) was measured using Triton X-100 emulsified-[14C] triolein. The remaining activity in the presence of 1M NaCl was defined as HTGL activity. Serum adiponectin levels were determined by an enzyme-linked immunosorbent assay system.
  
  
  RESULTS
  LPL activity had a positive relationship with HDL2, but had no relation with HDL3, while HTGL had positive relationship with HDL3, but had no relationship with HDL2. LPL activity showed a positive relationship [r = 0.345, p = 0.010] to serum adiponectin levels, while and HTGL activity showed an inverse relationship [r = - 0.365 p = 0.006]. Multiple regression analysis with LPL and HTGL as dependent variables and age, BMI, serum adiponectin and the homeostasis model assessment of insulin resistance (HOMA-IR) as independent variables showed LPL and HTGL's association to adiponectin did not persist after adjustments for these covariants. However, the association of LPL activity to HOMA-IR was found to persist after adjustments of age, BMI, and serum adiponectin.
  
  
  CONCLUSIONS
  There was a co-linearity between insulin sensitivity and adiponectin as well as insulin sensitivity and LPL/HTGL activity.
authors.affiliation: Department of Lifestyle-related disease, Kanazawa University Graduate School of Medical Science, Takara-machi 13-1, Japan. Junji@med.kanazawa-u.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Kusunoki
authors.forename: Y
authors.initials: Y
authors.lastname: Murase
authors.forename: M
authors.initials: M
authors.lastname: Kawashiri
authors.forename: T
authors.initials: T
authors.lastname: Higashikata
authors.forename: K
authors.initials: K
authors.lastname: Miwa
authors.forename: S
authors.initials: S
authors.lastname: Katsuda
authors.forename: M
authors.initials: M
authors.lastname: Takata
authors.forename: A
authors.initials: A
authors.lastname: Asano
authors.forename: A
authors.initials: A
authors.lastname: Nohara
authors.forename: A
authors.initials: A
authors.lastname: Inazu
authors.forename: H
authors.initials: H
authors.lastname: Mabuchi
mesh_terms: D000368:Aged; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D007564:Japan; D008049:Lipase / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
chemical_list: D008049:Lipase; D008071:Lipoprotein Lipase