title: [Soy protein intake and bone mineral density].
abstract: It has been reported that soy protein prevents the bone loss in in vitro and in vivo studies. Isoflavones contained in soy stimulate the protein synthesis and the expression of alkalinephophatases in osteoblasts. Additionally food enriched isoflavones prevented the reduction of bone mineral density (BMD) in ovariectomised rats or mice. We demonstrated the association of soy protein intake with the increase of BMD and the inhibition of urinary deoxypyridinoline. Interventional studies also exhibited the prevention of the reduction of BMD. However double-blind, randomized case-control trial does not support the hypothesis that use of soy protein supplement containing isoflavones improve BMD. We need further to detect the more potent isoflavones on bone metabolism.
authors.affiliation: Department of Enclocrinology, Tokyo Metropolitan Geriatric Hospital.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Horiuchi
mesh_terms: D000368:Aged; D000818:Animals; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology; D051379:Mice; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D030262:Soybean Proteins / Q000008:administration & dosage*
chemical_list: D007529:Isoflavones; D030262:Soybean Proteins; C065753:isoflavanone