title: Activities of red blood cell anti-oxidative enzymes (SOD, GPx) and total anti-oxidative capacity of serum (TAS) in men with coronary atherosclerosis and in healthy pilots.
abstract: BACKGROUND
  Reactive oxygen species (ROS) have been proposed to play important pathogenic roles, especially in harmful oxidative modifications of low-density cholesterol. Redox balance within the organism is largely determined by the activities of anti-oxidative enzymes of red blood cells and by the total anti-oxidative capacity of the serum (TAS).
  
  
  METHODS
  SOD and GPx activities and TAS in 13 men aged 42-65 years with coronary atherosclerosis (group I) were compared with those of both 15 clinically healthy pilots matched for age and lipid abnormalities (cholesterol and triglycerides) (group II) and 14 age-matched pilots without lipid abnormalities (group III).
  
  
  RESULTS
  There were statistically significant differences in SOD and GPx activities and in TAS between the groups.
  
  
  CONCLUSIONS
  1. SOD and GPx activities and TAS were lower in men with advanced coronary atherosclerosis that in age-matched clinically healthy men with similar dyslipidemia and were even further decreased compared with clinically healthy men without dyslipidemia. 2. The decrease in SOD and GPx activities and TAS in men with advanced coronary atherosclerosis was more pronounced than the degree of hypercholesterolemia or hypertriglyceridemia. 3. If hyperlipidemia and the activity of antioxidative enzymes and TAS were considered without reference to other risk factors of atherosclerosis, it appeared that the decreases in SOD, GPx, and TAS may play a more important role in the development of the atherosclerotic process than isolated increases in free cholesterol or triglyceride levels.
authors.affiliation: Department of Internal Disease of the Polish Air Force Institute of Aviation Medicine, Warsaw, Poland. ezawadzka@wiml.waw.pl
authors.forename: Ewelina
authors.initials: E
authors.lastname: Zawadzka-Bartczak
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D014280:Triglycerides; D002784:Cholesterol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase