Myeloid/NK cell precursor acute leukemia lost both CD13 and CD33 at first diagnosis.
It has been reported that malignancies of natural killer (NK) cell precursors, which are present in both myeloid and lymphoid antigens, are characterized by immature lymphoblastoid morphology with CD7+, CD33+ and CD56+ phenotype. Here, we report a 18-year-old man who was diagnosed with CD33- and CD13- NK cell precursor acute leukemia at first diagnosis. Following a 3-year remission state, he had a relapse as a testicular tumor and CD33+ myeloid/NK cell precursor acute leukemia after allogenic BMT. This case suggests that myeloid antigens are not necessary for diagnosis of myeloid/NK cell precursor acute leukemia.
Ogura
Kazuto
K
Third Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
Kimura
Fumihiko
F
Kobayashi
Shinichi
S
Torikai
Hiroki
H
Ikeda
Takashi
T
Sato
Ken
K
Motoyoshi
Kazuo
K
D000293:Adolescent; D015703:Antigens, CD / Q000097:blood*; D019011:Antigens, CD7 / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood*; D016026:Bone Marrow Transplantation; D018826:CD13 Antigens / Q000097:blood*; D019002:CD56 Antigen / Q000097:blood; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D012008:Recurrence; D063268:Sialic Acid Binding Ig-like Lectin 3; D013736:Testicular Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D014184:Transplantation, Homologous
D015703:Antigens, CD; D019011:Antigens, CD7; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D019002:CD56 Antigen; D063268:Sialic Acid Binding Ig-like Lectin 3; D018826:CD13 Antigens