[Expression of S100 protein in renal cell carcinoma and its relation with P53].
OBJECTIVE
To investigate the expression of S100 in renal cell carcinoma (RCC) and its relation with P53.


METHODS
Immunohistochemical method was used to detect the expressions of S100A1, S100B and the mutant P53 in 36 RCC and 14 normal kidney tissues. The associations of S100 protein expression with the tumor pathological types, clinical stages and P53 expression were analyzed.


RESULTS
The positive rates of S100A1 expression in RCC and normal kidney tissues were 72.2% and 21.4%, respectively (P <0.01); S100A1 expression in RCC was significantly correlated with its stage and degree of malignancy. The positive rates of the mutant P53 expression in RCC and normal kidney tissues were 30. 6% and zero respectively (P <0.05), and its expression was not associated with the stage and degree of malignancy degree of RCC (P > 0.05). There was no significant difference in S100B expression between RCC (36.1%) and normal kidney tissues (64.3%, P >0.05). There was no significant correlation between the mutant P53 and S100A1 or S100B expression (P > 0.05).


CONCLUSIONS
S100A1 may serve as a new useful marker in judging the degree of malignancy and invasion of RCC.
Yang
Jian-Fu
JF
Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhang
Xiang-Yang
XY
Qi
Fan
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell / Q000378:metabolism*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009418:S100 Proteins / Q000096:biosynthesis* / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D014408:Biomarkers, Tumor; D009418:S100 Proteins; C110294:S100A1 protein; D016159:Tumor Suppressor Protein p53