title: [Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders].
abstract: Myelin oligodendrocyte glycoprotein (MOG) is a myelin-specific protein of the central nervous system (CNS). It is a member of the immunoglobulin superfamily. The contents of this protein in oligodendrogliocyte membrane is very low (approximately 0.1% total proteins). Functions of MOG are still unknown. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals. The structure, membrane topology, putative functions and role in demyelinating diseases are considered in this review.
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
authors.forename: A V
authors.initials: AV
authors.lastname: Semenova
authors.forename: O I
authors.initials: OI
authors.lastname: Gurina
authors.forename: T B
authors.initials: TB
authors.lastname: Dmitrieva
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D020278:Demyelinating Autoimmune Diseases, CNS / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D009836:Oligodendroglia / Q000378:metabolism*
chemical_list: C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein