[Expression of leukemia inhibitory factor gene in decidua from women with habitual abortion].
To evaluate the relationship between habitual abortion of unknown etiology and expression of leukemia inhibitory factor (LIF) gene in the decidua,the expression of LIF gene in the decidua were detected in 32 cases of habitual abortion of unknown etiology (abortion group) and 36 cases of normal pregnancy (control group) by reverse transcription-polymerase chain reaction (RT-PCR). The results showed that the level of LIF mRNA expression of the decidua in abortion group was 0.512+/-0.219, significantly lower than those in the control group (1.314+/-0.457, P<0.01). The findings indicated that the low expression of LIF gene in abortion group might be one of the causes of habitual abortion. Analysis on the LIF gene expression of decidua can be used as a index for diagnosis of the habitual abortion.
Li
Gang
G
Department of Genetics, Chongqing Medical University, Chongqing 400016, China. lg168sn@sina.com
Wang
Ying-Xiong
YX
Liu
Xue-Qing
XQ
Weng
Ya-Guang
YG
He
Jun-Lin
JL
Chen
Xue-Mei
XM