Apoptosis as a mechanism of autoimmune inflammation in human knee joint.
Apoptosis in the cartilage and synovial membrane of the knee joint in patients with rheumatoid arthritis was studied using the immunocytochemical TUNEL method. The degree of apoptosis correlated with the duration of inflammation. The process predominated in the chondroblast population, lymphocytic infiltration, and synovial membrane fibroblasts.
Dubikov
A I
AI
Department of Histology, Vladivostok State Medical University. aihavlad@online.vladivostok.ru
Belogolovykh
L A
LA
Medved'
E E
EE
D000328:Adult; D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology*; D005453:Fluorescence; D006801:Humans; D020287:In Situ Nick-End Labeling; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000378:metabolism*