Coincidence detection in phosphoinositide signaling.
Phosphoinositide lipids function as both signaling molecules and as compartment-specific localization signals for phosphoinositide-binding proteins. In recent years, both phosphoinositides and phosphoinositide-binding proteins have been reported to display a restricted, rather than a uniform, distribution across intracellular membranes. Here, we examine recent data documenting the restricted distribution of both phosphoinositides and phosphoinositide-binding proteins and examine how phosphoinositide-binding proteins might engage multiple binding partners to achieve these restricted localizations, effectively acting as detectors of coincident localization signals.
Carlton
Jez G
JG
Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.
Cullen
Peter J
PJ
D004789:Enzyme Activation; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D021962:Membrane Microdomains; D008958:Models, Molecular; D015394:Molecular Structure; D010716:Phosphatidylinositols / Q000737:chemistry* / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*
D008055:Lipids; D010716:Phosphatidylinositols