Tetanic crisis and antiepileptic drugs. A case report.
OBJECTIVE
We presented a rare case of tetanic crisis in a 23-year old mentally retarded woman with epilepsy after treatment by oxcarbazepine, the new anticonvulsant agent. We reviewed laboratory, radiographic and medical examinations and recommend a proper treatment in such cases.


CONCLUSIONS
The laboratory tests revealed only severe hypocalcemia. We described the potential role of oxcarbazepine in the induction of activity of cytochrome P 450 system of hepar and increases of less active metabolism of vitamin D. Supplementation of vitamin D and calcium in patients taking antiepileptic drugs is in the same case crucial.
Zdrojewicz
Zygmunt
Z
Department of Endocrinology & Diabetology, Wroclaw Medical University, Wroclaw, Poland.
Dubiński
Andrzej
A
Jonek
Aneta
A
Tomanek
Natalia
N
Krajewski
Włodzimierz
W
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002118:Calcium / Q000008:administration & dosage; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004830:Epilepsy, Tonic-Clonic / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced / Q000188:drug therapy; D008607:Intellectual Disability / Q000150:complications; D000078330:Oxcarbazepine; D013746:Tetany / Q000139:chemically induced* / Q000188:drug therapy; D014807:Vitamin D / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
D000927:Anticonvulsants; D014815:Vitamins; D014807:Vitamin D; D002220:Carbamazepine; D002118:Calcium; D000078330:Oxcarbazepine