title: Tensile creep properties of interpenetrating networks containing gelatin and poly(ethylene glycol) diacrylate.
abstract: The tensile creep properties of an interpenetrating networks (IPN) system containing polyanionic ethylenediaminetetraacetic dianhydride (EDTAD)-modified gelatin and poly(ethylene glycol) diacrylate (PEGdA) of 600 or 2000 Da at various weight ratios were determined under different pH and load levels. A computerized creep testing device was designed following ASTM D2990 and validated to establish the environment-dependent structure-function relationship of IPNs. IPNs containing PEGdA 2000 Da or EDTAD-modified gelatin showed less strain than those formulated with PEGdA 600 Da or unmodified gelatin, respectively. IPN formulated with 40 wt% gelatin showed higher strain than those with 50 or 30 wt% gelatin. Increasing strain in IPN was observed with increasing load level. IPN strain was higher at pH 7 when compared to pH 4 or 10. The creep characteristics of this complex macromolecular system are dependent on both environmental and composition factors.
authors.affiliation: Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53705, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Toth
authors.forename: Kelly
authors.initials: K
authors.lastname: Williams
authors.forename: Shannon
authors.initials: S
authors.lastname: Hayes
authors.forename: Weiyuan John
authors.initials: WJ
authors.lastname: Kao
mesh_terms: D000812:Anhydrides / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry; D004548:Elasticity; D005780:Gelatin / Q000737:chemistry*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*; D013718:Tensile Strength; D014783:Viscosity
chemical_list: D000812:Anhydrides; D001672:Biocompatible Materials; C437167:poly(ethylene glycol)diacrylate; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D005780:Gelatin; D004492:Edetic Acid