Simultaneous determination of chlorinated bacteriostats in cosmetic and pharmaceutical products.
A high-performance liquid chromatography method has been developed for simultaneous determination of triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) and triclocarban (3,4,4'-trichlorocarbanilide) in cosmetic and pharmaceutical products. The two compounds could be separated on a Nucleosil C(18) column and eluted with acetonitrile and water (70:30, v/v) as the mobile phase and detected with a differential refractive index detector. The retention times of triclosan and triclocarban were 5.81 and 2.99 min, respectively. The results obtained were in good agreement with those obtained by a differential pulse voltammetric method.
Wang
Lai-Hao
LH
Department of Applied Chemistry, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 71743, R.O.C.
Tso
Mey
M
Chin
Chun-Yu
CY
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D002224:Carbanilides / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012031:Refractometry; D013056:Spectrophotometry, Ultraviolet; D014260:Triclosan / Q000032:analysis*
D000891:Anti-Infective Agents, Local; D002224:Carbanilides; D003358:Cosmetics; D004364:Pharmaceutical Preparations; D014260:Triclosan; C009540:triclocarban