INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women.
The relevance of the insulin gene (INS) variable number tandem repeat (VNTR) polymorphism to indexes of body size and adult obesity is inconclusive. Given the equivocal reports on the association between the VNTR class genotype at the insulin gene locus and indexes of body size and obesity, we assessed these associations in a series of cohort studies based on 7,999 middle-aged men and women. We found no convincing evidence that INS VNTR class genotype was associated with indexes of body size and adult obesity. These data suggest that INS VNTR class is not an important determinant of size and body weight regulation in middle-aged men and women.
Sandhu
Manjinder S
MS
Department of Public Health & Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, UK. manj.sandhu@srl.cam.ac.uk
Heude
Barbara
B
Young
Elizabeth H
EH
Luben
Robert
R
Luan
Jian'an
J
Khaw
Kay-Tee
KT
Todd
John
J
Wareham
Nicholas J
NJ
D000368:Aged; D049628:Body Size / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
D007328:Insulin