Efficacy of inactivated hepatitis A vaccine in HIV-infected patients: a hierarchical bayesian meta-analysis.
Patients with human immunodeficiency virus-1 (HIV) have elevated risk for hepatitis A virus (HAV) coinfection. Sequelae from coinfection include increased risk of liver-related morbidity and mortality. This study synthesizes the results of trials measuring response to HAV vaccine in HIV-infected patients using Bayesian meta-analysis methodologies. PubMed, OhioLINK/Medline, and other sources were used to search for studies analyzing response to HAV vaccine in HIV-infected patients. Studies were evaluated for quality. A Bayesian hierarchical random-effects model was used to estimate overall response to vaccine. Between-study variance was calculated. Sensitivity analyses were conducted to determine the potential for bias. The literature search yielded eight studies for inclusion in the meta-analysis, with a combined total of 458 patients. Observed proportions of response in individual studies ranged from 50 to 95%. The intention-to-treat meta-analysis estimated a combined proportion of HIV+ patients responding to vaccine of 64% (95% CI 52-75%). Heterogeneity between studies was significant. The overall response rate to HAV vaccine in HIV-infected patients is lower than typically cited. Up to 1/2 of HIV-infected patients may be nonresponders. Future research will be required to better understand the correlates of response.
Shire
Norah J
NJ
College of Medicine, University of Cincinnati, 231 Albert Sabin Way, ML-0595, Cincinnati, OH 45267, USA. norah.shire@uc.edu
Welge
Jeffrey A
JA
Sherman
Kenneth E
KE
D001499:Bayes Theorem; D003627:Data Interpretation, Statistical; D015658:HIV Infections / Q000276:immunology*; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006801:Humans; D015233:Models, Statistical; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology
D022362:Hepatitis A Vaccines; D015164:Vaccines, Inactivated