Hormonal and nonhormonal mechanisms of regulation of the NA,K-pump in collecting duct principal cells.
In the kidney, the collecting duct (CD) is the site of final Na+ reabsorption, according to Na+ balance requirements. In this segment of the renal tubule, principal cells may reabsorb up to 5% of the filtered sodium. The driving force for this process is provided by the basolateral Na,K-adenosine triphosphatase (ATPase) (sodium pump). Na,K-ATPase activity and expression in the CD are modulated physiologically by hormones (aldosterone, vasopressin, and insulin) and nonhormonal factors including intracellular [Na+] and extracellular osmolality. In this article, we review the short- and long-term hormonal regulation of Na,K-ATPase in CD principal cells, and we analyze the integrated network of implicated signaling pathways with an emphasis on the latest findings.
Vinciguerra
Manlio
M
Service de Nephrologie, Fondation pour Recherches Medicales, Genève, Switzerland.
Mordasini
David
D
Vandewalle
Alain
A
Feraille
Eric
E
D000450:Aldosterone / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D006490:Hemostatics / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology / Q000502:physiology; D007685:Kidney Tubules, Collecting / Q000166:cytology* / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000502:physiology*; D014667:Vasopressins / Q000494:pharmacology / Q000502:physiology
D006490:Hemostatics; D006728:Hormones; D007004:Hypoglycemic Agents; D007328:Insulin; D014667:Vasopressins; D000450:Aldosterone; D000254:Sodium-Potassium-Exchanging ATPase