title: Effects of scalpel (with and without tissue adhesive) and cryosurgery on wound healing in rat tongues.
abstract: OBJECTIVE
  To evaluate wound healing of incisions created by steel scalpel (with and without the application of N-butyl-2-cyanoacrylate) and cryosurgery.
  
  
  METHODS
  Prospective blinded and randomized study. Adult albino rats (N = 93) were randomly assigned to 3 groups (31 animals per group) before making incisions on oral mucosa by steel scalpel (2 groups) or cryosurgical techniques (remaining group). No product was applied to the resulting wound in the first group, while N-butyl-2-cyanoacrylate was applied to the wounds made in the tongues of the second group. Hemostasis, postoperative oral intake, and wound healing were measured. Statistical analysis was performed using analysis of variance.
  
  
  RESULTS
  The wounds to which N-butyl-2-cyanoacrylate had been applied showed no hemorrhaging and faster reepithelialization and resolution of the inflammatory response, and the animals gained weight more rapidly.
  
  
  CONCLUSIONS
  N-butyl-2-cyanoacrylate is a good hemostatic for managing wounds in the oral mucosa provoked by steel scalpel.
authors.affiliation: University of Murcia, Murcia, Spain. fabiosurgery@hotmail.com
authors.forename: Fabio
authors.initials: F
authors.lastname: Camacho-Alonso
authors.forename: Pía
authors.initials: P
authors.lastname: López-Jornet
authors.forename: Ambrosio
authors.initials: A
authors.lastname: Bermejo-Fenoll
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016063:Blood Loss, Surgical / Q000517:prevention & control; D003452:Cryosurgery; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use*; D008297:Male; D009584:Nitrogen; D019647:Oral Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014059:Tongue / Q000601:surgery*; D015430:Weight Gain; D014945:Wound Healing
chemical_list: D006490:Hemostatics; D014014:Tissue Adhesives; D004659:Enbucrilate; D009584:Nitrogen