title: Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation.
abstract: Genetic aberrations have emerged as major prognostic factors for patients with multiple myeloma (MM). We evaluated 126 MM patients for t(4;14) or t(11;14), 13q or p53 deletions and correlated the number of genetic aberrations with patient's clinical outcome following undergoing autologous stem cell transplantation. We demonstrate the significance of genetic-based risk classification that clearly segregate patients into low (no genetic abnormalities or only t(11;14)), intermediate (any one of the genetic abnormalities other than t(11;14)) and high-risk groups (any two or more of the genetic abnormalities other than t(11;14)). High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies.
authors.affiliation: Department of Laboratory Hematology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada. hong.chang@uhn.on.ca
authors.forename: H
authors.initials: H
authors.lastname: Chang
authors.forename: X Y
authors.initials: XY
authors.lastname: Qi
authors.forename: S
authors.initials: S
authors.lastname: Samiee
authors.forename: Q-L
authors.initials: QL
authors.lastname: Yi
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Trudel
authors.forename: J
authors.initials: J
authors.lastname: Mikhael
authors.forename: D
authors.initials: D
authors.lastname: Reece
authors.forename: A K
authors.initials: AK
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D002872:Chromosome Deletion; D002877:Chromosomes, Human / Q000235:genetics*; D000529:Complementary Therapies; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D012307:Risk Factors; D033581:Stem Cell Transplantation / Q000379:methods; D014178:Translocation, Genetic; D014182:Transplantation, Autologous; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53