Lambda integrase: armed for recombination.
Bacteriophage lambda moves its viral genome into and out of the bacterial chromosome using site-specific recombination. Crystal structures of reaction intermediates in this recombination pathway provide exciting new snapshots of full length lambda integrase interacting with both core and regulatory DNA elements.
Van Duyne
Gregory D
GD
Department of Biochemistry & Biophysics, Howard Hughes Medical Institute University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. vanduyne@mail.med.upenn.edu
D010582:Bacteriophage lambda / Q000201:enzymology* / Q000235:genetics*; D004247:DNA / Q000378:metabolism*; D019426:Integrases / Q000378:metabolism*; D008954:Models, Biological; D011995:Recombination, Genetic / Q000235:genetics*; D016662:Virus Integration / Q000502:physiology*
D004247:DNA; D019426:Integrases