Postantibiotic effect of DX-619 against 16 gram-positive organisms.
The in vitro postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA-SMEs), and the sub-MIC effects (SMEs) of DX-619 were determined for 16 gram-positive organisms. DX-619 pneumococcal, staphylococcal, and enterococcal PAE ranges were 1.7 to 5.0 h, 0.7 to 1.8 h, and 1.2 to 6.5 h, respectively. The PA-SME ranges (0.4x MIC) for pneumococci, staphylococci, and enterococci were 5.2 to >8.6 h, 2.1 to 8.3 h, and 4.9 to >10.0 h, respectively.
Pankuch
G A
GA
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Appelbaum
P C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; C505440:DX 619; D011759:Pyrrolidines; D015363:Quinolones