title: Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.
abstract: The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5550, USA. roh@leland.stanford.edu
authors.forename: R
authors.initials: R
authors.lastname: O'Hara
authors.forename: C M
authors.initials: CM
authors.lastname: Schröder
authors.forename: H C
authors.initials: HC
authors.lastname: Kraemer
authors.forename: N
authors.initials: N
authors.lastname: Kryla
authors.forename: C
authors.initials: C
authors.lastname: Cao
authors.forename: E
authors.initials: E
authors.lastname: Miller
authors.forename: A F
authors.initials: AF
authors.lastname: Schatzberg
authors.forename: J A
authors.initials: JA
authors.lastname: Yesavage
authors.forename: G M
authors.initials: GM
authors.lastname: Murphy
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology; D004252:DNA Mutational Analysis; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D018384:Oxidative Stress / Q000235:genetics; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D012894:Sleep Stages / Q000235:genetics
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E