[Advances in molecular mechanisms of human sperm-egg interaction and infertility].
Human sperm-egg recognition, adhesion and fusion are key steps in the whole reproductive process. Some abnormalities in human gamete interaction have been shown to be due to defects in the sperm, others attributed to defects in the zona pellucida (ZP) and the egg plasma membrane. This paper reviews the molecular basis and molecular mechanisms of human sperm-egg interaction. More and more advances in the studies of these aspects are shown to be of significant value to the diagnosis and treatment of infertility as well as to the development of assisted reproductive techniques.
Song
Li-Wen
LW
Shanghai Research Institute of Planned Parenthood, Shanghai 200032, China.
Wang
Yu-Bao
YB
D020101:Acrosome Reaction / Q000502:physiology; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology*; D008297:Male; D013084:Sperm-Ovum Interactions / Q000502:physiology*; D015044:Zona Pellucida