title: Subclinical inflammation and soleus muscle intramyocellular lipids in healthy Asian Indian males.
abstract: OBJECTIVE
  The relationship between C-reactive protein (CRP), a marker of subclinical inflammation, and intramyocellular lipid (IMCL) content, a novel correlate of insulin resistance, has not previously been investigated.
  
  
  METHODS
  We estimated IMCL content in soleus muscle in 30 healthy Asian Indian males using proton magnetic resonance spectroscopy ((1)H MRS), and correlated it with body mass index (BMI), measures of abdominal obesity, percentage of body fat (%BF), serum lipoproteins, fasting and post-oral glucose load serum insulin levels and other surrogate markers of insulin resistance.
  
  
  RESULTS
  Soleus muscle IMCL content was significantly correlated with age (rho=0.64, P<0.001), BMI (rho=0.41, P<0.05), %BF (rho=.53, P<= 0.01), waist circumference (rho=0.45, P<0.05) and waist-to-hip circumference ratio (rho=0.58, P<0.01) but did not correlate significantly with insulin resistance measured by the homeostasis model assessment (HOMA-IR) or CRP levels. CRP levels did not correlate with the HOMA-IR value.
  
  
  CONCLUSIONS
  Soleus muscle IMCL content correlated significantly with measures of generalized and abdominal obesity but not with insulin sensitivity or CRP levels in healthy Asian Indian males. Studies are needed in other ethnic groups to corroborate these data.
authors.affiliation: Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sinha
authors.forename: Manish
authors.initials: M
authors.lastname: Rathi
authors.forename: Anoop
authors.initials: A
authors.lastname: Misra
authors.forename: Virendra
authors.initials: V
authors.lastname: Kumar
authors.forename: Mahesh
authors.initials: M
authors.lastname: Kumar
authors.forename: N R
authors.initials: NR
authors.lastname: Jagannathan
authors.forename: Ravindra Mohan
authors.initials: RM
authors.lastname: Pandey
authors.forename: Manjari
authors.initials: M
authors.lastname: Dwivedi
authors.forename: Kalpana
authors.initials: K
authors.lastname: Luthra
mesh_terms: D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D007194:India; D007249:Inflammation; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007424:Intracellular Fluid / Q000737:chemistry; D016014:Linear Models; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000737:chemistry; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000166:cytology; D009765:Obesity / Q000208:ethnology / Q000276:immunology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D007328:Insulin; D008055:Lipids; D002097:C-Reactive Protein