Ultraviolet B radiation-induced immunosuppression: molecular mechanisms and cellular alterations.
About 30 years ago, the discovery of the connection between UV radiation and the immune system triggered the field of photoimmunology. In that time, many aspects were studied, and a complex picture emerged. UV absorption results in multi-tiered molecular and cellular UV radiation-induced events, eventually affecting the immune system. The shorter wavelengths of the UV spectrum, i.e. UVB appear to be the most critical players for impairing immune reactions. This review summarizes and discusses UVB radiation-induced effects on the skin, considering the primary efferent molecular events following energy absorption of UVB radiation, ending with the various afferent cellular changes, such as induction of regulatory T cells.
Schade
Nicole
N
Institut für Umweltmedizinische Forschung (IUF), (Institute for Environmental Medical Research at the Heinrich-Heine University Duesseldorf gGmbH), Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Esser
Charlotte
C
Krutmann
Jean
J
D000818:Animals; D002462:Cell Membrane / Q000528:radiation effects; D004249:DNA Damage; D004817:Epidermis / Q000528:radiation effects; D006801:Humans; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D007109:Immunity / Q000528:radiation effects*; D015603:Keratinocytes / Q000528:radiation effects; D017382:Reactive Oxygen Species; D014466:Ultraviolet Rays
D017382:Reactive Oxygen Species