Virus-glycopolymer conjugates by copper(I) catalysis of atom transfer radical polymerization and azide-alkyne cycloaddition.
The Cu(I)-catalyzed ATRP and azide-alkyne cycloaddition reactions together provide a versatile method for the synthesis of end-functionalized glycopolymers and their attachment to a suitably modified viral protein scaffold.
Sen Gupta
Sayam
S
Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, USA.
Raja
Krishnaswami S
KS
Kaltgrad
Eiton
E
Strable
Erica
E
Finn
M G
MG
D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D005947:Glucose / Q000737:chemistry*; D006384:Hemagglutination; D037102:Lectins; D011108:Polymers / Q000138:chemical synthesis; D014764:Viral Proteins / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D037102:Lectins; D011108:Polymers; D014764:Viral Proteins; D003300:Copper; D005947:Glucose