title: Dynamic susceptibility contrast perfusion imaging of cerebral ischemia in nonhuman primates: comparison of Gd-DTPA and NMS60.
abstract: OBJECTIVE
  To study a new gadolinium (Gd) contrast agent-NMS60-for MR perfusion-weighted imaging (PWI) of brain tissue.
  
  
  METHODS
  NMS60 is a Gd3+ trimer with a molecular weight of 2158 Daltons, and a T2 relaxivity almost three times higher than that of Gd-DTPA. Middle cerebral artery (MCA) occlusion was induced in nine nonhuman primates. The animals were scanned acutely and for up to six follow-up time points. PWI peak, and time-to-peak maps were generated, and perfusion deficit volumes were measured from these maps. The values of peak, time-to-peak, and perfusion deficit volume were compared between NMS60 and GD-DTPA.
  
  
  RESULTS
  These results demonstrate that there was no significant difference in our calculated perfusion parameters between the two contrast agents.
  
  
  CONCLUSIONS
  The two agents were found to be equally effective for PWI for acute and chronic stroke in primates. Along with its previously demonstrated advantage for T1-enhanced imaging, the current results show that NMS60 is a viable contrast agent for use in stroke patients.
authors.affiliation: Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
authors.forename: Yutong
authors.initials: Y
authors.lastname: Liu
authors.forename: Helen
authors.initials: H
authors.lastname: D'Arceuil
authors.forename: Julian
authors.initials: J
authors.lastname: He
authors.forename: Mike
authors.initials: M
authors.lastname: Duggan
authors.forename: S
authors.initials: S
authors.lastname: Seri
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: Akira
authors.initials: A
authors.lastname: Nakatani
authors.forename: R Gilberto
authors.initials: RG
authors.lastname: Gonzalez
authors.forename: Johnny
authors.initials: J
authors.lastname: Pryor
authors.forename: Alex
authors.initials: A
authors.lastname: de Crespigny
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis*; D003287:Contrast Media; D019786:Gadolinium DTPA; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis; D008251:Macaca; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; C403805:NMS60; D009942:Organometallic Compounds; D019786:Gadolinium DTPA