[Inhibition effects of phosphorothioate-modified antisense hTR on the telomerase activity and the growth of P3 cells derived from pancreatic cancer in culture].
This paper is to investigate PS-ODN's (antisense-PS-ODN of hTR,sense-PS-ODN of hTR and random sequence) effects on telomerase activity and proliferation of P3 pancreatic cancer cells,and to find a novel method for gene therapy of pancreatic cancer. The results indicate that the anti-hTR complementary to the template region of hTR is sufficient to inhibit P3 cell telomerase activity and cell proliferation in vitro,and as a result, they can lead to a profound induction of programmed cell death. Telomerase represents an interesting and promising anticancer drug target and anti-telomerase technology may have potential significance in tumor therapy.
Zhang
Hong-Mei
HM
The Genetic Centre of Southeast University, Nanjing 210009, China. zhm210009@yahoo.com.cn
Zhang
Li-Shan
LS
Yang
De-Tong
DT
Zhou
Jia-Hua
JH
Hong
Ze-Hui
ZH