Inflammatory issues in allergic rhinitis and asthma.
Allergic rhinitis and asthma are both systemic inflammatory disorders with similar pathophysiological mechanisms involving numerous cells and inflammatory mediators. Some airway remodeling also might exist in allergic rhinitis. This review has summarized selected investigative studies from our division and has addressed the effect of various therapeutic agents on nasal fluid, nasal and airway epithelial cells, and the concept of airway remodeling.
Frieri
Marianne
M
Division of Allergy Immunology, Department of Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USA.
D000402:Airway Obstruction / Q000209:etiology / Q000503:physiopathology; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D009296:Nasal Cavity / Q000187:drug effects / Q000473:pathology; D017817:Nasal Lavage Fluid; D012130:Respiratory Hypersensitivity / Q000150:complications / Q000473:pathology / Q000503:physiopathology*
D018926:Anti-Allergic Agents; D018836:Inflammation Mediators