title: Tin(IV) complexes of pyrrolidinedithiocarbamate: synthesis, characterisation and antifungal activity.
abstract: The reaction of ammonium pyrrolidinedithiocarbamate, [NH4{S2CN(CH2)4}], with SnCl2, [Sn(C6H5)2Cl2], [Sn(C6H5)3Cl], [Sn(C4H9)2Cl2] and [Sn(C6H11)3Cl] produced in good yield the compounds [Sn{S2CN(CH2)4}2Cl2] (1), [Sn{S2CN(CH2)4}2Ph2] (2), [Sn{S2CN(CH2)4}Ph3] (3), [Sn{S2CN(CH2)4}2 n-Bu2] (4) and [Sn{S2CN(CH2)4}Cy3] (5). The complexes were characterised by infrared, multinuclear NMR (1H, 13C{1H} and 119Sn{1H}) and 119Sn Mössbauer spectroscopies. In addition, the crystal structure of 4 was determined by X-ray crystallography. The in vitro antifungal activity of the tin(IV) complexes as well of the ligand was performed on human pathogenic fungi, Candida albicans, in concentrations of 0.025; 0.050; 0.100; 0.200; 0.400; 0.800; 1.600 and 3.200 mM. The microorganism presented resistance to the dithiocarbamate ligand and all tin(IV) complexes tested were actives. The highest activity was found for compounds 1 and 4.
authors.affiliation: Laboratório de Química de Coordenação e Organometálica do Estanho, Departamento de Química, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG CEP 31270-901, Brazil.
authors.forename: D C
authors.initials: DC
authors.lastname: Menezes
authors.forename: F T
authors.initials: FT
authors.lastname: Vieira
authors.forename: G M
authors.initials: GM
authors.lastname: de Lima
authors.forename: A O
authors.initials: AO
authors.lastname: Porto
authors.forename: M E
authors.initials: ME
authors.lastname: Cortés
authors.forename: J D
authors.initials: JD
authors.lastname: Ardisson
authors.forename: T E
authors.initials: TE
authors.lastname: Albrecht-Schmitt
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011759:Pyrrolidines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000737:chemistry*; D014001:Tin / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D008024:Ligands; D009942:Organometallic Compounds; D011759:Pyrrolidines; D013859:Thiocarbamates; C020972:pyrrolidine dithiocarbamic acid; D014001:Tin