Liposomal encapsulation of lauroyl-indapamide in the presence of divalent or trivalent cations.
Divalent or trivalent cations such as Ca2+, Ba2+, Mg2+, Zn2+, Fe2+, Al3+ and Fe3+ can cause a significant increase in the entrapment efficiency of lauroyl-indapamide in liposomes, from about 5% to more than 90%, which suggests that the presence of these ions plays an important role in the encapsulation of lauroyl-indapamide.
Suo
Xu-Bin
XB
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang City, PR China. suoxubin2008cn@yahoo.com.cn
Deng
Ying-Jie
YJ
D000465:Algorithms; D002138:Calibration; D002412:Cations / Q000737:chemistry*; D002413:Cations, Divalent / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D000431:Ethanol; D007190:Indapamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D002412:Cations; D002413:Cations, Divalent; D008081:Liposomes; D012997:Solvents; C502363:lauroyl indapamide; D000431:Ethanol; D007190:Indapamide