title: Hypoadiponectinemia is associated with coronary artery spasm in men.
abstract: BACKGROUND
  The relationship between adiponectin and coronary spastic angina (CSA), both of which are closely involved in coronary endothelial dysfunction, has not been elucidated.
  
  
  RESULTS
  Plasma adiponectin concentrations were examined in 55 men with CSA and 55 with chest pain syndrome (CPS). The plasma log-adiponectin levels were significantly lower in patients with CSA than with CPS (0.61+/-0.28 vs 0.80+/-0.21 microg/ml, p < 0.0001). The prevalence of smoking was significantly higher in the CSA patients than in those with CPS (50.9% vs 29.1%, p = 0.0195). In multiple logistic regression analysis, log-adiponectin (p = 0.0008) and smoking (p = 0.0210) were independent determinants of CSA. Conclusions Hypoadiponectinemia is a potential risk factor for CSA in men, independent of smoking.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Maruyoshi
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Otsuka
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaikita
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Iichiro
authors.initials: I
authors.lastname: Shimomura
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000097:blood*
chemical_list: D052242:Adiponectin