Mitochondrial membrane permeabilization by HIV-1 Vpr.
The mitochondrion is a privileged target for apoptosis-modulatory proteins of viral origin. Thus, viral protein R (Vpr) can target mitochondria and induce apoptosis via a specific interaction with the permeability transition pore complex (PTPC). Vpr cooperates with the adenine nucleotide translocator (ANT) to form large conductance channels and to trigger all the hallmarks of mitochondrial membrane permeabilization (MMP). The Vpr/ANT interaction is direct, since it is abolished by the addition of a peptide corresponding to the Vpr binding site of ANT, ADP, ATP, or by Bcl-2. Accordingly, Vpr modulates MMP through direct structural and functional interactions with PTPC proteins.
Deniaud
Aurélien
A
CNRS FRE 2445, Université de Versailles/St Quentin, 45, avenue des Etats-Unis, 78035 Versailles, France.
Brenner
Catherine
C
Kroemer
Guido
G