title: Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives and evaluation as antibacterials.
abstract: A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India. kidwai_chemistry@yahoo.co.uk
authors.forename: M
authors.initials: M
authors.lastname: Kidwai
authors.forename: S
authors.initials: S
authors.lastname: Saxena
authors.forename: M Khalilur Rahman
authors.initials: MK
authors.lastname: Khan
authors.forename: S S
authors.initials: SS
authors.lastname: Thukral
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011799:Quinazolines; D009643:Norfloxacin