title: A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'.
abstract: The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.
authors.affiliation: Schools of Biology and Medicine, University of St. Andrews, KY16 9TS, UK. fjg1@st-and.ac.uk
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Gunn-Moore
authors.forename: Gavin I
authors.initials: GI
authors.lastname: Welsh
authors.forename: Lissa R
authors.initials: LR
authors.lastname: Herron
authors.forename: Frances
authors.initials: F
authors.lastname: Brannigan
authors.forename: Kanamarlapudi
authors.initials: K
authors.lastname: Venkateswarlu
authors.forename: Stewart
authors.initials: S
authors.lastname: Gillespie
authors.forename: Margaret
authors.initials: M
authors.lastname: Brandwein-Gensler
authors.forename: Rashna
authors.initials: R
authors.lastname: Madan
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Tavaré
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Brophy
authors.forename: Michael B
authors.initials: MB
authors.lastname: Prystowsky
authors.forename: Simon
authors.initials: S
authors.lastname: Guild
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010743:Phospholipids / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D000099149:Ezrin
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001798:Blood Proteins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010743:Phospholipids; D010750:Phosphoproteins; D011993:Recombinant Fusion Proteins; D000099149:Ezrin; C504793:FRMD6 protein, human; C071058:moesin; C071776:radixin