Pregnancy outcome in patients with primary Sjögren's syndrome. a case-control study.
OBJECTIVE
To study the outcome of pregnancy in patients with primary Sjögren's syndrome (pSS).


METHODS
A questionnaire covering demographic data and the outcome of pregnancies was answered by 58 patients with pSS and 157 controls. For 36 patients and 93 controls, we analyzed detailed data about pregnancy, birth, and status of the newborn from the Medical Birth Registry of Norway (MFR) for birth order one, 2, and 3. Thirty-two of 36 patients registered in MFR were diagnosed with pSS after the last birth.


RESULTS
Pregnancy outcomes were not different in patients compared to controls. Two patients (3.4%) reported giving birth to a child with congenital heart block.


CONCLUSIONS
PSS had no impact on pregnancy outcome before disease onset. The most important condition associated with pSS in anti-SSA positive mothers was congenital heart block in the offspring.
Haga
Hans-Jacob
HJ
Department of Rheumatology, Esbjerg Central Hospital, 6700 Esbjerg, Denmark. HJH@ribeamt.dk
Gjesdal
Clara Gram
CG
Koksvik
Hege Svean
HS
Skomsvoll
Johan Fredrik
JF
Irgens
Lorentz M
LM
Ostensen
Monika
M
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008423:Maternal Age; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology*; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis*; D011795:Surveys and Questionnaires