A systematic approach to managing pregnant dialysis patients--the importance of an intensified haemodiafiltration protocol.
BACKGROUND
Pregnancy is still uncommon in women on maintenance dialysis; and their outcomes is reported to have improved to 40% to 85% live births. Here, we report the successful multidisciplinary management of five consecutive pregnant dialysis patients.


METHODS
In our centre, we treated each of five patients with a systematically intensified haemodiafiltration protocol, increased erythropoeitin dosages, a generous administration of water-soluble vitamins and trace elements, and a multidisciplinary clinical management approach with a very low threshold for hospitalization.


RESULTS
All patients received haemodiafiltration at least 6 times/week, an average of 28.6+/-6.3 h/week. We achieved a mean weekly Kt/Vdp of 9.6+/-1.4 and urea reduction rates of 54.8+/-29.4%. The mean erythropoeitin dose was increased from 169+/-94 IU/kg/week prior to admission at our centre to 314+/-111 IU/kg/week after the initiation of intensified haemodiafiltration. Haemoglobin levels increased from 8.9+/-1.9 g/dl to 10.7+/-0.5 g/dl. Mean gestational age at delivery was 32.8+/-3.3 weeks and mean birth weight was 1765+/-554 g. The length of hospital stay amounted to 85+/-61 days for the mothers and 26+/-18 days for the newborns, and all were discharged healthy.


CONCLUSIONS
These modified management guidelines led to favourable outcomes in all our patients, and may help to guide therapy in other pregnant dialysis patients.
Haase
Michael
M
Departments of Nephrology, Charité University Hospital CCM, Berlin, Germany. michael.haase@charite.de
Morgera
Stanislao
S
Bamberg
Christian
C
Halle
Horst
H
Martini
Sebastian
S
Hocher
Berthold
B
Diekmann
Fritz
F
Dragun
Duska
D
Peters
Harm
H
Neumayer
Hans-H
HH
Budde
Klemens
K
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000097:blood / Q000628:therapy*; D017583:Hemodiafiltration / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007902:Length of Stay; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011446:Prospective Studies; D014508:Urea / Q000097:blood
D006454:Hemoglobins; D014508:Urea