title: Effects of phosphatidylserine on oxidative stress following intermittent running.
abstract: OBJECTIVE
  The aim of the study was to investigate the effects of 750 mg of soybean-derived phosphatidylserine or a glucose polymer placebo, administered daily for 10 d, on markers of oxidative stress, perceived soreness, and muscle damage initiated by intermittent exercise (designed to simulated soccer match play) immediately followed by an exhaustive run.
  
  
  METHODS
  Following familiarization, 16 male soccer players completed an exhaustive intermittent exercise protocol on two further occasions (T1 and T2) separated by approximately 14 d. Ten days before T2, the subjects were assigned, in a double-blind manner, to receive either phosphatidylserine (PS) or a placebo (P). Exercise time to exhaustion, sprint performance, ratings of perceived exertion, and HR were recorded throughout both main exercise trials. Venous blood samples were obtained at rest (preexercise), 15 min following exercise (postexercise), 24 h after exercise (post-24 h), and 48 h after exercise (post-48 h).
  
  
  RESULTS
  Preexercise and postexercise concentrations of plasma gamma-tocopherol were increased following supplementation in PS, although supplementation had no effect on plasma concentrations of other nonenzymatic antioxidants (vitamin C, alpha-tocopherol, retinol, and beta-carotene). Serum cortisol concentrations, perceived soreness, markers of muscle damage (creatine kinase (CK) and myoglobin (Mb)), and lipid peroxidation (hydroperoxides and conjugated diene lag times) were elevated to an equal extent in PS and P following exhaustive exercise before and following supplementation. The changes in running times to exhaustion from T1 to T2 in PS and P were 4.2 +/- 0.7 and -3.7 +/- 4.2%, respectively (P = 0.084).
  
  
  CONCLUSIONS
  Supplementation with phosphatidylserine was not effective in attenuating the cortisol response, perceived soreness, and markers of muscle damage and lipid peroxidation following exhaustive running; however, supplementation tended to increase running time to exhaustion. Therefore, future research should be undertaken to investigate the potential ergogenic properties of this supplement.
authors.affiliation: department of Sports Science, University of Wales Swansea, Swansea, United Kingdom. M.I.C.Kingsley@Swansea.ac.uk
authors.forename: Michael I
authors.initials: MI
authors.lastname: Kingsley
authors.forename: Daniel
authors.initials: D
authors.lastname: Wadsworth
authors.forename: Liam P
authors.initials: LP
authors.lastname: Kilduff
authors.forename: Jane
authors.initials: J
authors.lastname: McEneny
authors.forename: David
authors.initials: D
authors.lastname: Benton
mesh_terms: D000328:Adult; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000494:pharmacology*; D012420:Running; D012916:Soccer; D006113:United Kingdom
chemical_list: D010718:Phosphatidylserines