title: [Foot tumor and diffuse pain: a case of oncogenic osteomalacia].
abstract: Oncogenic osteomalacia is a rare clinicopathologic entity, linked to a mesenchymal tumor which overexpresses a hypophosphatemic factor, supposed to be the FGF-23. To date, about 100 cases have been published. We report the case of a 40-year-old man who presented an osteomalacic syndrome with no classical etiological diagnosis. The discovery of a subcutaneous tumor of the right foot and a high serum level of FGF-23 suggested the diagnosis of oncogenic osteomalacia. Surgical removal of the tumor resulted in complete reversal of the clinical and biochemical defects. Pathologic examination revealed spindle cells associated with osteoclast-like giant cells, embedded within a myxoid matrix which showed floculent calcification. These observations were compatible with the features of PMTMCT (Phosphaturic mesenchymal tumor mixed connective tissue variant).
authors.affiliation: Service d'Anatomie et Cytologie Pathologiques, CH Gui-de-Chauliac, 80 rue Augustin Fliche, 34295 Montpellier Cedex 5, France.
authors.forename: Flora
authors.initials: F
authors.lastname: Poizat
authors.forename: Anne
authors.initials: A
authors.lastname: Wojtusciszin
authors.forename: Pierre
authors.initials: P
authors.lastname: Raynaud
authors.forename: Hélène
authors.initials: H
authors.lastname: Maître
authors.forename: Eacute Ric
authors.initials: ER
authors.lastname: Renard
authors.forename: Pierre
authors.initials: P
authors.lastname: Baldet
mesh_terms: D000328:Adult; D002455:Cell Division; D003937:Diagnosis, Differential; D000089703:Fibroblast Growth Factor-23; D005534:Foot Diseases / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010010:Osteoclasts / Q000473:pathology; D010018:Osteomalacia / Q000473:pathology* / Q000503:physiopathology; D010146:Pain; D013577:Syndrome