title: Regulatory effects of cytokine production in atopic allergic reaction by gammi-danguieumja.
abstract: Gammi-danguieumja (GD) is clinically used in South Korea for treating atopic dermatitis. However, its effects in experimental models remain unknown. We investigated a possible effect of GD on cytokines production using human T cell line (MOLT-4) or human mast cell line. As a result, GD (0.01 mg/mL)-containing medium in stimulated culture supernatants increased IL-2 and IFN-gamma, and decreased IL-4 secretion in MOLT-4. GD (0.01-1 mg/mL)-containing medium in stimulated culture supernatants dose-dependently and significantly decreased IL-8, IL-13, and tumor necrosis factor-alpha secretion on the phorbol 12-myristate 13-acetate and A23187-stimulated HMC-1. In addition, GD inhibited histamine release from activated mast cells. These results suggest that GD contributes to the regulation of atopic allergic reactions.
authors.affiliation: College of Oriental Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul, South Korea.
authors.forename: Ho-Jeong
authors.initials: HJ
authors.lastname: Na
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Na-Hyung
authors.initials: NH
authors.lastname: Kim
authors.forename: Mi-Won
authors.initials: MW
authors.lastname: Kwon
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Park
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Nam-Il
authors.initials: NI
authors.lastname: Kim
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology* / Q000633:toxicity; D000001:Calcimycin; D002460:Cell Line; D002470:Cell Survival; D016207:Cytokines / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D007476:Ionophores; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D003189:p-Methoxy-N-methylphenethylamine
chemical_list: D018926:Anti-Allergic Agents; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; D007476:Ionophores; D014409:Tumor Necrosis Factor-alpha; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; C016658:phorbolol myristate acetate; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate