title: Timing of surgical intervention does not influence return of esophageal peristalsis or outcome for patients with achalasia.
abstract: BACKGROUND
  It has been suggested that abnormal function of the lower esophageal sphincter is the primary abnormality in esophageal achalasia, and that the absence of esophageal peristalsis is secondary to the outflow obstruction caused by the lower esophageal sphincter. Furthermore, it has been proposed that early elimination of the resistance at the level of the gastroesophageal junction by surgical intervention could result in return of esophageal peristalsis. This study aimed to assess whether the timing of surgical intervention affects the return of esophageal peristalsis and the clinical outcome for patients with achalasia.
  
  
  METHODS
  Between January 1991 and May 2003, 173 patients underwent a Heller myotomy by minimally invasive surgery for treatment of esophageal achalasia. Of these patients, 41 (24%) had pre- and postoperative esophageal manometry. These patients were divided into three groups based on the duration of symptoms: group A (10 patients; duration of symptoms 12 months group B (19 patients, duration of symptoms 12 to 60 months), and group C (12 patients; duration of symptoms longer than 60 months).
  
  
  RESULTS
  The average duration of symptoms (dysphagia was present in all patients) was as follows: group A (8 +/- 4 months), group B, (35 +/- 16 months), and group C, (157 +/- 94 months). Vigorous achalasia was present in 40%, 21%, and 17% of the groups respectively. The differences between the groups were not significant. Postoperatively, improvement in esophageal motility was seen in no patient in group A, 1 patient (5%) in group B, and 1 patient (8%) in group C. Excellent or good results were obtained for 90% of the group A patients, 95% of group B patients, and 92% of the group C patients. Again, the differences were not significant.
  
  
  CONCLUSIONS
  The results show that: a) the presence of vigorous achalasia is independent of symptoms duration; b) the timing of surgical intervention does not influence the return of peristalsis; and c) the results of a Heller myotomy are independent of symptoms duration.
authors.affiliation: Department of Surgery and Swallowing Center, University of California, San Francisco, 533 Parnassus Avenue, Room U-122, San Francisco, CA 94143-0788, USA. pattim@surgery.ucsf.edu
authors.forename: M G
authors.initials: MG
authors.lastname: Patti
authors.forename: C
authors.initials: C
authors.lastname: Galvani
authors.forename: M V
authors.initials: MV
authors.lastname: Gorodner
authors.forename: P
authors.initials: P
authors.lastname: Tedesco
mesh_terms: D004931:Esophageal Achalasia / Q000601:surgery*; D004947:Esophagus / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010528:Peristalsis; D020127:Recovery of Function; D013997:Time Factors