title: Enantioselective organocatalytic Michael addition of malonate esters to nitro olefins using bifunctional cinchonine derivatives.
abstract: A family of 9-amino(9-deoxy) epicinchonine derivatives, possessing a range of mono- and bidentate hydrogen bond donor groups at the 9-position, were synthesised and evaluated for asymmetric organocatalytic activity in the dimethyl malonate Michael addition to beta-nitrostyrene; thiourea derivative was identified as the most effective bifunctional organic catalyst and found to induce high enantioselectivity in the malonate ester Michael addition reaction to a range of nitro olefins.
authors.affiliation: School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK M13 9PL.
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
authors.forename: Peter S
authors.initials: PS
authors.lastname: Hynes