title: Early virological events in various tissues of newborn monkeys after intrarectal infection with pathogenic simian human immunodeficiency virus.
abstract: Children infected with human immunodeficiency virus type 1 often have higher viral loads and progress to acquired immunodeficiency syndrome more rapidly than adults. In our previous study of simian-human immunodeficiency virus (SHIV)-infected adult monkeys, immature CD4CD8 double-positive T cells in the thymus and jejunum decreased faster than mature CD4 single-positive T cells. Here, we examined the effect of virus replication on immature T cells from the same SHIV-inoculated newborn monkeys having more immature T cells than adults. The infectious viruses were more abundantly detected in the thymus than in other tissues at both 13 and 26 days post-infection (dpi). However, mature CD4(+) T cells in the thymus declined after 13 dpi and immature CD3(-) CD4 single-positive T cells remained at 26 dpi. These results suggested that many immature CD4(+) T cells in the thymus of newborns support the production of infectious viruses even after the depletion of mature CD4(+) T cells.
authors.affiliation: Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: Ariko
authors.initials: A
authors.lastname: Miyake
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ibuki
authors.forename: Hajime
authors.initials: H
authors.lastname: Suzuki
authors.forename: Reii
authors.initials: R
authors.lastname: Horiuchi
authors.forename: Naoki
authors.initials: N
authors.lastname: Saito
authors.forename: Makiko
authors.initials: M
authors.lastname: Motohara
authors.forename: Masanori
authors.initials: M
authors.lastname: Hayami
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Miura
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D017931:DNA Primers; D005434:Flow Cytometry / Q000662:veterinary; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D017958:Lentiviruses, Primate / Q000276:immunology* / Q000502:physiology; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000276:immunology* / Q000821:virology*; D011533:Proviruses / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D013950:Thymus Gland / Q000821:virology; D013997:Time Factors; D014766:Viremia / Q000235:genetics; D014779:Virus Replication / Q000502:physiology
chemical_list: D017931:DNA Primers