Associations of Fas (CD95), tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), and biochemical manifestations in elderly persons.
BACKGROUND
This study investigated the relationships of soluble Fas (CD95) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) vs. biochemical manifestations.


METHODS
Serum concentrations of soluble Fas, TRAIL, and biochemical parameters were measured in 171 healthy adults.


RESULTS
There were no significant age- and gender-related differences in Fas and TRAIL concentrations. However, aspartate and alanine aminotransferase and gamma-glutamyl transferase (AST, ALT, and GGT) activities were significantly higher in men with Fas > or =429.5 and TRAIL > or =63.2 pg/ml than in those with Fas <429.5 and TRAIL <63.2 pg/ml (26.8+/-10.9, 33.2+/-14.6, and 79.2+/-46.9 IU/l vs. 17.6+/-4.6, 20.4+/-7.8, and 35.3+/-21.3 IU/l, p<0.05, respectively). Serum triglyceride, total protein, and uric acid concentrations averaged 172.8+/-58.4 mg/dl, 7.8+/-0.3 g/dl, and 4.8+/-1.1 mg/dl in women with Fas > or =352.1 and TRAIL > or =64.9 pg/ml, which were significantly above the values of those with Fas <352.1 and TRAIL <64.9 pg/ml (116.9+/-49.2 mg/dl, 7.4+/-0.3 g/dl, and 3.7+/-0.7 mg/dl, p<0.05, respectively). Serum soluble Fas concentrations correlated significantly with AST (r=0.36, p<0.05), ALT (r=0.30, p<0.05), and GGT (r=0.29, p<0.05) in men and triglyceride (r=0.34, p<0.05), protein (r=0.27, p<0.05), and uric acid levels (r=0.41, p<0.05) in women.


CONCLUSIONS
Apoptotic activity seems to have an important relationship to biochemical parameters, especially hepatic enzymes, total protein, triglyceride, and uric acid in elderly persons.
Choi
Jong Weon
JW
Department of Laboratory Medicine, College of Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Incheon 400-711, South Korea.
D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001774:Blood Chemical Analysis; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D011485:Protein Binding; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor