title: Focal non-typhoidal Salmonella infections from a single center in Malaysia.
abstract: A retrospective review of patients with focal non-typhoidal Salmonella (NTS) infection was performed to determine its features and outcome. All patients with focal NTS infection admitted to the University of Malaya Medical Center, Malaysia, from 1993 to 2002 were studied. More than half (58%) of the 35 cases (54% male, median age 39 years, range 1.5 months to 79 years) were immunocompromized or had chronic medical conditions. One-third of the patients (34%) had superficial infections (lymphadenitis or subcutaneous tissue infection) and all recovered with antimicrobial therapy alone. Deep infections (66%) noted were: meningitis (9%), osteomyelitis or arthritis (26%), abscesses of the gastrointestinal tract or adjacent organs (20%), and others (11%). Deep infections were more likely to occur in the extremes of age (<6 months or >60 years, p< 0.04), associated with adverse outcomes with an overall mortality rate of 9%, or required major surgery (15%).
authors.affiliation: Department of Pediatrics, University of Malaya Medical Center, Kuala Lumpur, Malaysia. leews@um.edu.my
authors.forename: W S
authors.initials: WS
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Hafeez
authors.forename: H
authors.initials: H
authors.lastname: Hassan
authors.forename: N S
authors.initials: NS
authors.lastname: Raja
authors.forename: S D
authors.initials: SD
authors.lastname: Puthucheary
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002494:Central Nervous System Infections / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D005490:Focal Infection / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D005759:Gastroenteritis / Q000382:microbiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008199:Lymphadenitis / Q000382:microbiology; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012475:Salmonella / Q000187:drug effects / Q000302:isolation & purification*; D012480:Salmonella Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D017192:Skin Diseases, Bacterial / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents