title: Growth hormone releaser attenuates beta-amyloid (1 - 42)-induced memory impairment in mice.
abstract: Accumulating evidence indicates that growth hormone (GH) might be effective at preventing the development of Alzheimer's disease. However, exogenous GH treatment has exhibited side effects for clinical application; thus supplementation with amino acids to promote the release of GH could be a possible alternative treatment. In this study, mice that were fed with a diet of GH-releasing supplements had significantly attenuated memory impairments and hippocampal changes in the acetylcholinesterase activity and acetylcholine level induced by amyloid beta protein (Abeta) (1 - 42). Our results suggest that the use of GH-releasing supplement exerts beneficial effects on the memory impairment induced by Abeta (1 - 42).
authors.affiliation: Neurotoxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
authors.forename: Eun-Joo
authors.initials: EJ
authors.lastname: Shin
authors.forename: Jin Hyeong
authors.initials: JH
authors.lastname: Jhoo
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
authors.forename: Wang-Kee
authors.initials: WK
authors.lastname: Jhoo
authors.forename: Myung Sang
authors.initials: MS
authors.lastname: Kwon
authors.forename: Yong Kwang
authors.initials: YK
authors.lastname: Lim
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Chae
authors.forename: Myung Eun
authors.initials: ME
authors.lastname: Jung
authors.forename: Seok Joo
authors.initials: SJ
authors.lastname: Park
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Jang
authors.forename: Hyoung-Chun
authors.initials: HC
authors.lastname: Kim
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D001923:Brain Chemistry; D013006:Growth Hormone / Q000097:blood* / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000037:antagonists & inhibitors*; D013997:Time Factors
chemical_list: D000596:Amino Acids; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D013006:Growth Hormone; D000110:Acetylcholinesterase; D000109:Acetylcholine