Microdamage and apoptosis.
Microdamage of healthy bone leads to targeted removal and repair of the damage. This process must involve the production of specific targeting signals. The identity of these signals is unknown but constitutes a legitimate research goal since it is this targeting process which appears to become impaired in ageing and disease. Here we discuss the potential role of the matrix bound osteocyte in the sensing and targeting of microdamage. In particular we will review current understanding concerning the apoptotic death of osteocytes at sites of microdamage and discuss the potential physiological significance of these findings in the light of knowledge of the significance of apoptosis in other cell systems.
Noble
Brendon
B
Scottish Mechanotransduction Consortium, University of Edinburgh Medical School, Edinburgh, UK. Brendon.Noble@ed.ac.uk
D000375:Aging; D000818:Animals; D017209:Apoptosis; D001862:Bone Resorption; D001842:Bone and Bones / Q000473:pathology*; D017102:Fracture Healing; D015775:Fractures, Stress; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009336:Necrosis; D010010:Osteoclasts / Q000378:metabolism; D010011:Osteocytes / Q000378:metabolism / Q000473:pathology; D010587:Phagocytosis; D015398:Signal Transduction
D008024:Ligands