title: Cerebral solitary Langerhans cell histiocytosis: report of two cases and review of the literature.
abstract: Cerebral solitary Langerhans cell histiocytosis (LCH) is a very uncommon condition. We describe two new cases: a 30-year-old man with seizures and a tumour in the left frontal lobe, which was composed of a polymorphic infiltrate with a predominance of histiocytes and eosinophils; and a 65-year-old man with headaches and dysarthria, with a left parietal tumour, which showed a diffuse proliferation of histiocytic cells and areas of necrosis. In both cases, the histiocytes were strongly positive for S-100 and CD1a, and Birbeck's granules were demonstrated by electron microscopy in the first case. Both patients underwent a complete excision of their lesions. The second patient received additional postoperative radiotherapy. They were asymptomatic after 26 and 27 months, respectively. It seems that cerebral solitary LCH is a clinicopathological entity with a good outcome. Only 15 cases of this rare process have been previously reported in the English literature.
authors.affiliation: Department of Pathology, Hospital General de Castellón, Castellón, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez-Pereira
authors.forename: J M
authors.initials: JM
authors.lastname: Borrás-Moreno
authors.forename: J V
authors.initials: JV
authors.lastname: Pesudo-Martínez
authors.forename: J M
authors.initials: JM
authors.lastname: Vera-Román
mesh_terms: D000328:Adult; D000368:Aged; D018949:Antigens, CD1 / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D009418:S100 Proteins / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D018949:Antigens, CD1; D009418:S100 Proteins