title: Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta.
abstract: 2,6-Diamino-4,N-diarylpyridines were identified as potent, isoform selective inhibitors of the enzymatic activity of lysophosphatidic acid acyltransferase-beta (LPAAT-beta).
authors.affiliation: Cell Therapeutics, Inc., 201 Elliott Ave. W., Suite 400, Seattle, WA 98119, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Hong
authors.forename: David
authors.initials: D
authors.lastname: Hollenback
authors.forename: Jack W
authors.initials: JW
authors.lastname: Singer
authors.forename: Peter
authors.initials: P
authors.lastname: Klein
mesh_terms: D000217:Acyltransferases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007536:Isomerism; D020033:Protein Isoforms; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D020033:Protein Isoforms; D011725:Pyridines; D000217:Acyltransferases; C018764:2-acylglycerophosphate acyltransferase