Study of neurotrophic activity of thrombin on the model of regenerating mouse nerve.
Experiments demonstrated a dose-dependent facilitating effect of thrombin and peptide thrombin receptor agonist PAR1 (TRAP6) on regeneration of mouse peripheral nerve after its crushing. The maximum neurotrophic effect was observed at low concentrations of thrombin (10 nM) and TRAP6 (10 microM).
Balezina
O P
OP
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. balezina@mail.ru
Gerasimenko
N Yu
NY
Dugina
T N
TN
Strukova
S M
SM
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009416:Nerve Regeneration / Q000187:drug effects*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology*; D044463:Receptor, PAR-1 / Q000819:agonists*; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology*
D009842:Oligopeptides; D044463:Receptor, PAR-1; C504808:Ser-Phe-Phe-Leu-Arg-Asn; D013917:Thrombin