title: Post-prandial hyperglycemia is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients.
abstract: Diabetic microangiopathy is often observed in diabetic patients, but there is little evidence regarding the relationship between post-prandial glycemia or insulinemia and the incidence of diabetic microangiopathy. In this study, to elucidate the relationship between post-prandial glycemia (or insulinemia) and diabetic microangiopathy, we performed a cross-sectional study of 232 subjects with type 2 diabetes mellitus who were not being treated with insulin injections. A multiple regression analysis showed that post-prandial hyperglycemia independently correlated with the incidence of diabetic retinopathy and neuropathy. Post-prandial hyperglycemia also correlated, although not independently, with the incidence of diabetic nephropathy. In addition, interestingly, post-prandial hypoinsulinemia independently correlated with the incidence of diabetic retinopathy, although not correlated with diabetic neuropathy or nephropathy. In conclusion, post-prandial hyperglycemia, rather than fasting glycemia or hemoglobin A1c levels, is an important predictor of the incidence of diabetic microangiopathy in Japanese type 2 diabetic patients.
authors.affiliation: Department of Internal Medicine and Therapeutics (A8), Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita City, Osaka 565-0871, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shiraiwa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyatsuka
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Kaoru
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Ayaha
authors.initials: A
authors.lastname: Kawashima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kanda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Suzuki
authors.forename: Eiichi
authors.initials: E
authors.lastname: Imano
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Yamasaki
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D003925:Diabetic Angiopathies / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period