title: [Study on preparation technology of limonene dropping pills].
abstract: OBJECTIVE
  To study the technical preparation of limonene dropping pills.
  
  
  METHODS
  Orthogonal test was applied to optimize the preparation of limonene dropping pills.
  
  
  RESULTS
  The optimized project was as follow: the matrix contained PEG4000: PEG6000 (1:1.5); the refrigerant was liquid paraffin; the rate of limonene to matrix was 1:6 and the temperature of limonene was 70 degrees C; the internal and external diameter of burette was 2.0 mm and 2.4 mm, respectively; the burette was 4cm above the surface of refrigerant; drug was dropped into refrigerant of 15 degrees C at 45 drops per minute.
  
  
  CONCLUSIONS
  The results provide the data for the ascertainment of shaping operation of limonene dropping pills at the manufacturing scale.
authors.affiliation: Pharmaceutical College, Jinan University, Guangzhou.
authors.forename: Zhenxia
authors.initials: Z
authors.lastname: Xu
authors.forename: Ligui
authors.initials: L
authors.lastname: Gong
authors.forename: Aifeng
authors.initials: A
authors.lastname: Zhang
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
mesh_terms: D000704:Analysis of Variance; D053138:Cyclohexenes; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000077222:Limonene; D010946:Plants, Medicinal / Q000737:chemistry*; D011108:Polymers; D027821:Rutaceae / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013729:Terpenes / Q000302:isolation & purification*; D013997:Time Factors
chemical_list: D053138:Cyclohexenes; D004365:Drugs, Chinese Herbal; D011108:Polymers; D013729:Terpenes; D000077222:Limonene