title: Life and death of lymphocytes: a role in immunesenescence.
abstract: Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two major pathways of apoptosis, namely death receptor pathway and mitochondrial pathway, and their alterations in both T and B lymphocytes in human aging with a special emphasis on naïve and different memory subsets of CD8+ T cells. We will also discuss a possible role of lymphocyte apoptosis in immune senescence.
authors.affiliation: Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA. sgupta@uci.edu
authors.forename: Sudhir
authors.initials: S
authors.lastname: Gupta
authors.forename: Houfen
authors.initials: H
authors.lastname: Su
authors.forename: Ruifen
authors.initials: R
authors.lastname: Bi
authors.forename: Sudhanshu
authors.initials: S
authors.lastname: Agrawal
authors.forename: Sastry
authors.initials: S
authors.lastname: Gollapudi