title: SPK-843 (Aparts/Kaken).
abstract: SPK-843 is a water-soluble antibiotic under co-development by Aparts and Kaken for the potential treatment of systemic fungal infections. By November 2004, SPK-843 was in phase II trials for systemic mycosis.
authors.affiliation: Department of Pharmacognosy, National Center for Natural Product Research, School of Pharmacy, The University of Mississippi, MS 38677, USA.
authors.forename: Noer
authors.initials: N
authors.lastname: Kasanah
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use* / Q000633:toxicity*; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D010330:Patents as Topic; D011090:Polyenes / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use* / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D011090:Polyenes; C115650:SPA S 843