title: Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?
abstract: L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.
authors.affiliation: Laboratoire de Physiologie de la Perception et de l'Action, UMR CNRS 7152, 11 place Marcelin Berthelot, Collège de France, 75005 Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Burguière
authors.forename: Angelo
authors.initials: A
authors.lastname: Arleo
authors.forename: Mohammad reza
authors.initials: Mr
authors.lastname: Hojjati
authors.forename: Ype
authors.initials: Y
authors.lastname: Elgersma
authors.forename: Chris I
authors.initials: CI
authors.lastname: De Zeeuw
authors.forename: Alain
authors.initials: A
authors.lastname: Berthoz
authors.forename: Laure
authors.initials: L
authors.lastname: Rondi-Reig
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002531:Cerebellum / Q000166:cytology*; D004924:Escape Reaction / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010468:Perceptual Disorders / Q000235:genetics / Q000503:physiopathology*; D011493:Protein Kinase C / Q000235:genetics; D011597:Psychomotor Performance / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology*; D011930:Reaction Time / Q000235:genetics; D013037:Spatial Behavior / Q000502:physiology*; D013997:Time Factors
chemical_list: D011493:Protein Kinase C