Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?
L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.
Burguière
Eric
E
Laboratoire de Physiologie de la Perception et de l'Action, UMR CNRS 7152, 11 place Marcelin Berthelot, Collège de France, 75005 Paris, France.
Arleo
Angelo
A
Hojjati
Mohammad reza
Mr
Elgersma
Ype
Y
De Zeeuw
Chris I
CI
Berthoz
Alain
A
Rondi-Reig
Laure
L
D000222:Adaptation, Physiological / Q000235:genetics / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002531:Cerebellum / Q000166:cytology*; D004924:Escape Reaction / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010468:Perceptual Disorders / Q000235:genetics / Q000503:physiopathology*; D011493:Protein Kinase C / Q000235:genetics; D011597:Psychomotor Performance / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology*; D011930:Reaction Time / Q000235:genetics; D013037:Spatial Behavior / Q000502:physiology*; D013997:Time Factors
D011493:Protein Kinase C