[Ethomerzol as an antioxidant].
Ethomerzol (25 mg/kg, intraperitaneally, 30 min before hypoxia) prevents lipid peroxidation activation and antioxidant system suppression in brain and liver of albino rats at acute hypoxia. Injection of ethomerzol decreases accumulation of conjugated diense and malondialdehyde, increases the levels of thiols and the activities of the antioxidant enzymes in the brain and the liver. In the model biological systems in vitro ethomerzol (0.01-40 mM) inhibits of Fe2+-induced ascorbate-dependent lipid peroxidation in a non-metabolizing model, such as liposomes, similar to DMSO and Fe2+-induced ascorbate- and NADPH-dependent lipid peroxidation in the brain homogenates similar to EDTA. Thus ethomerzol exhibits antioxidant properties.
Mironova
O P
OP
Zarubina
I V
IV
Shabanov
P D
PD
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004492:Edetic Acid / Q000737:chemistry; D004837:Epinephrine / Q000737:chemistry; D000860:Hypoxia / Q000378:metabolism / Q000517:prevention & control; D007501:Iron / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008081:Liposomes / Q000737:chemistry; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009249:NADP / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D000975:Antioxidants; D001562:Benzimidazoles; D008081:Liposomes; C070941:ethomersol; D009249:NADP; D004492:Edetic Acid; D007501:Iron; D001205:Ascorbic Acid; D004837:Epinephrine; D004121:Dimethyl Sulfoxide