A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes.
A highly efficient and practical approach for the synthesis of optically pure beta-amino alcohols by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes was developed. This method allows the preparation of a broad range of chiral beta-amino alcohols, including functionalized ones under mild conditions. It provides a straightforward access to enantiopure beta-amino alcohols that are widely applicable in asymmetric synthesis.
Zhong
Yu-Wu
YW
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
Dong
Yi-Zhou
YZ
Fang
Kai
K
Izumi
Kenji
K
Xu
Ming-Hua
MH
Lin
Guo-Qiang
GQ
D000447:Aldehydes / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D002073:Butanes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008956:Models, Chemical; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013441:Sulfinic Acids / Q000737:chemistry
D000447:Aldehydes; D000605:Amino Alcohols; D002073:Butanes; D007097:Imines; D013441:Sulfinic Acids