title: Axonal injury in experimental herpes simplex encephalitis.
abstract: Using beta-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. beta-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.
authors.affiliation: Department of Microbiology and Immunology, Aichi Medical University, School of Medicine, Aichi 480-1195, Japan. isamor@aichi-med-u.ac.jp
authors.forename: Isamu
authors.initials: I
authors.lastname: Mori
authors.forename: Fumi
authors.initials: F
authors.lastname: Goshima
authors.forename: Terukazu
authors.initials: T
authors.lastname: Mizuno
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Imai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kohsaka
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ito
authors.forename: Naoki
authors.initials: N
authors.lastname: Koide
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yoshida
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokochi
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nishiyama
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001369:Axons / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D002135:Calcium-Binding Proteins / Q000378:metabolism; D020803:Encephalitis, Herpes Simplex / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008840:Microfilament Proteins; D017628:Microglia / Q000378:metabolism / Q000473:pathology / Q000821:virology
chemical_list: C491049:Aif1 protein, mouse; D016564:Amyloid beta-Protein Precursor; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins