Pulmonary infiltrates with eosinophilia induced by nimesulide in an asthmatic patient.
We report a case of pulmonary infiltrates with eosinophilia (PIE) induced by nimesulide in an asthmatic patient on regular inhaled corticosteroid treatment. A high level of eosinophils in induced sputum was detected. No evidence of bacterial or fungal infection was observed. The patient responded rapidly to corticosteroid treatment. Rechallenge with nimesulide induced blood and sputum eosinophilia, confirming our diagnosis. Nimesulide, though it is a relatively safe drug to use in aspirin-sensitive asthmatics, may (like other nonsteroidal anti-inflammatory drugs) cause PIE in asthmatic patients and thus should be used cautiously.
Perng
Diahn-Warng
DW
Department of Chest Medicine, Taipei Veterans General Hospital, #201 Section 2 Shih-Pai Road, Taipei 11217, Taiwan, ROC. dwperng@vghtpe.gov.tw
Su
Hsuan-Tsung
HT
Tseng
Chih-Wei
CW
Lee
Yu-Chin
YC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D013449:Sulfonamides / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide