title: Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
abstract: Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 x 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan. kaseron@med.hokudai.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Kase
authors.forename: Wataru
authors.initials: W
authors.lastname: Saito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshida
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Osaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ohgami
authors.forename: Kenji
authors.initials: K
authors.lastname: Shiratori
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Adachi
authors.forename: Hisao
authors.initials: H
authors.lastname: Ito
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002452:Cell Count; D002830:Choroid Neoplasms / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D018572:Disease-Free Survival; D015353:Eye Enucleation; D015355:Glaucoma, Neovascular / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008545:Melanoma / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D008875:Middle Aged; D013939:Thymidine Phosphorylase / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D013939:Thymidine Phosphorylase