Low creatinine clearance, glucocorticoid treatment, rheumatoid arthritis--different etiologies for low D-hormone syndrome and its associated increased risk for falls.
Low D-hormone syndrome, a disorder related to low creatinine clearance (CrCl), is associated with a roughly 4-fold increase in risk for falls. Known conditions leading to low D-hormone syndrome are CrCl < 65 ml/min, drug interactions, and chronic inflammatory diseases. This article reviews recent studies showing that treatment with D-hormone analogs, such as alfacalcidol, can reduce the frequency of falls in patients with low D-hormone syndrome.
Dukas
Laurent C
LC
Acute Geriatric University Clinic, Kantonsspital, and Ambulatorium Wiesendamm, Basel, Switzerland.
Schacht
Erich
E
D000058:Accidental Falls / Q000517:prevention & control*; D000367:Age Factors; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D002117:Calcitriol / Q000097:blood / Q000172:deficiency*; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000378:metabolism*; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D012307:Risk Factors; D013250:Steroid Hydroxylases / Q000378:metabolism; D013577:Syndrome; D014815:Vitamins / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D005938:Glucocorticoids; D006887:Hydroxycholecalciferols; D014815:Vitamins; D003404:Creatinine; D013250:Steroid Hydroxylases; C406322:vitamin D 1-alpha hydroxylase; D002117:Calcitriol; C008088:alfacalcidol