Axonal injury in experimental herpes simplex encephalitis.
Using beta-amyloid precursor protein immunolabeling, we have detected axonal injury in experimental herpes simplex encephalitis. beta-amyloid precursor protein-specific signals were found in the mouse brain as either puncta or axon-like structures. They appeared where infected neurons were undergoing apoptosis and Iba1-immunopositive microglia transformed themselves into macrophages. These results show, for the first time, that axonal injury, i.e., functional disturbance of the fast axonal transport, can take place during the course of acute viral encephalitis.
Mori
Isamu
I
Department of Microbiology and Immunology, Aichi Medical University, School of Medicine, Aichi 480-1195, Japan. isamor@aichi-med-u.ac.jp
Goshima
Fumi
F
Mizuno
Terukazu
T
Imai
Yoshinori
Y
Kohsaka
Shinichi
S
Ito
Hiroyasu
H
Koide
Naoki
N
Yoshida
Tomoaki
T
Yokochi
Takashi
T
Kimura
Yoshinobu
Y
Nishiyama
Yukihiro
Y
D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001369:Axons / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D002135:Calcium-Binding Proteins / Q000378:metabolism; D020803:Encephalitis, Herpes Simplex / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008840:Microfilament Proteins; D017628:Microglia / Q000378:metabolism / Q000473:pathology / Q000821:virology
C491049:Aif1 protein, mouse; D016564:Amyloid beta-Protein Precursor; D002135:Calcium-Binding Proteins; D008840:Microfilament Proteins