First experience of the use bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns.
Female patient with extensive skin burn (I-II-IIIAB skin burn, total area 40%, area of IIIB degree 30%) was treated using transplantation of allogenic fibroblast-like bone marrow mesenchymal stem cells onto the surface of deep thermal burn. The study of wound healing dynamics after transplantation of allogenic fibroblast-like mesenchymal stem cells confirmed high tempo of wound regeneration in the presence of active neoangiogenesis. Due to this, autodermoplasty of burn wounds could be carried out with good results as early as on day 4 after transplantation of fibroblast-like mesenchymal stem cells; this led to more rapid healing of donor zones and accelerated rehabilitation of the patient.
Rasulov
M F
MF
Institute of Transplantology and Artificial Organs, Moscow, Russia.
Vasilchenkov
A V
AV
Onishchenko
N A
NA
Krasheninnikov
M E
ME
Kravchenko
V I
VI
Gorshenin
T L
TL
Pidtsan
R E
RE
Potapov
I V
IV
D001854:Bone Marrow Cells / Q000166:cytology*; D002056:Burns / Q000473:pathology / Q000628:therapy*; D005260:Female; D005347:Fibroblasts / Q000637:transplantation*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D012867:Skin / Q000293:injuries* / Q000473:pathology; D014945:Wound Healing / Q000502:physiology