Effect of ghrelin on activities of some lysosomal hydrolases in rabbits.
OBJECTIVE
Observing the changes of activity of some lysosomal enzymes in blood serum of female rabbits subjected to injection of 10 microg of ghrelin/kg of body weight.


METHODS
In the blood serum the activity of cathepsins D and L, alanine aminopeptidase, acid phosphatase, lysosomal lipase and lysosomal esterase was determined.


RESULTS
As a result of ghrelin injection the activity of all the enzymes examined in blood serum increased markedly.


CONCLUSIONS
Changes of lysosomal enzymes activities in the blood serum caused by the effects of ghrelin should be regarded as the response of the lysosomal system.
Witek
Bozena
B
Department of Genetics, Institute of Biology, Swietokrzyska Academy, Kielce, Poland. b.witek@pu.kielce.pl
Ochwanowska
Ewa
E
Rafay
Jan
J
Kolataj
Adam
A
Chrenek
Peter
P
Suvegova
Karin
K
Jurcik
Rastislav
R
Sirotkin
Alexander
A
Darlak
Krzysztof
K
D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D018826:CD13 Antigens / Q000097:blood; D002402:Cathepsin D / Q000097:blood; D056668:Cathepsin L; D002403:Cathepsins / Q000097:blood; D003546:Cysteine Endopeptidases / Q000097:blood; D004950:Esterases / Q000097:blood; D005260:Female; D054439:Ghrelin; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006867:Hydrolases / Q000097:blood*; D008049:Lipase / Q000097:blood; D008247:Lysosomes / Q000201:enzymology*; D036361:Peptide Hormones / Q000494:pharmacology*; D011817:Rabbits
D054439:Ghrelin; D036361:Peptide Hormones; D006867:Hydrolases; D004950:Esterases; D008049:Lipase; D000135:Acid Phosphatase; D002403:Cathepsins; D018826:CD13 Antigens; D003546:Cysteine Endopeptidases; D056668:Cathepsin L; D002402:Cathepsin D