title: Antisense transcription in the mammalian transcriptome.
abstract: Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. Global transcriptome analysis provides evidence that a large proportion of the genome can produce transcripts from both strands, and that antisense transcripts commonly link neighboring "genes" in complex loci into chains of linked transcriptional units. Expression profiling reveals frequent concordant regulation of sense/antisense pairs. We present experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals.
authors.affiliation: Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Centre (GSC), RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Katayama
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authors.initials: Y
authors.lastname: Tomaru
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authors.initials: T
authors.lastname: Kasukawa
authors.forename: K
authors.initials: K
authors.lastname: Waki
authors.forename: M
authors.initials: M
authors.lastname: Nakanishi
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authors.initials: M
authors.lastname: Nakamura
authors.forename: H
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authors.lastname: Nishida
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authors.initials: CC
authors.lastname: Yap
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Kawai
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: P
authors.initials: P
authors.lastname: Carninci
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashizaki
authors.forename: C
authors.initials: C
authors.lastname: Wells
authors.forename: M
authors.initials: M
authors.lastname: Frith
authors.forename: T
authors.initials: T
authors.lastname: Ravasi
authors.forename: K C
authors.initials: KC
authors.lastname: Pang
authors.forename: J
authors.initials: J
authors.lastname: Hallinan
authors.forename: J
authors.initials: J
authors.lastname: Mattick
authors.forename: D A
authors.initials: DA
authors.lastname: Hume
authors.forename: L
authors.initials: L
authors.lastname: Lipovich
authors.forename: S
authors.initials: S
authors.lastname: Batalov
authors.forename: P G
authors.initials: PG
authors.lastname: Engström
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: M A
authors.initials: MA
authors.lastname: Faghihi
authors.forename: A
authors.initials: A
authors.lastname: Sandelin
authors.forename: A M
authors.initials: AM
authors.lastname: Chalk
authors.forename: S
authors.initials: S
authors.lastname: Mottagui-Tabar
authors.forename: Z
authors.initials: Z
authors.lastname: Liang
authors.forename: B
authors.initials: B
authors.lastname: Lenhard
authors.forename: C
authors.initials: C
authors.lastname: Wahlestedt
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D051379:Mice / Q000235:genetics*; D034622:RNA Interference; D016372:RNA, Antisense / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D014158:Transcription, Genetic
chemical_list: D016372:RNA, Antisense; D012333:RNA, Messenger