SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD).
Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]beta-CIT and single photon emission computed tomography in subjects with obsessive-compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
Pogarell
Oliver
O
Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig-Maximilians-University of Munich, Nussbaumstr. 7, D-80336 Munich, Germany. oliver.pogarell@med.uni-muenchen.de
Poepperl
Gabriele
G
Mulert
Christoph
C
Hamann
Christine
C
Sadowsky
Nikolai
N
Riedel
Michael
M
Moeller
Hans-Juergen
HJ
Hegerl
Ulrich
U
Tatsch
Klaus
K
D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D015283:Citalopram / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology; D015899:Tomography, Emission-Computed, Single-Photon
D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors