title: HLA class I/NK cell receptor interaction in early human decidua basalis: possible functional consequences.
abstract: Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major subpopulation of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy expresses the polymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response.
authors.affiliation: INSERM U563, Hôpital Purpan Hopital Paule de Viguier, Toulouse, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Rabot
authors.forename: Julie
authors.initials: J
authors.lastname: Tabiasco
authors.forename: Beata
authors.initials: B
authors.lastname: Polgar
authors.forename: Maryse
authors.initials: M
authors.lastname: Aguerre-Girr
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.forename: Armand
authors.initials: A
authors.lastname: Bensussan
authors.forename: Natasa
authors.initials: N
authors.lastname: Strbo
authors.forename: Daniel
authors.initials: D
authors.lastname: Rukavina
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Bouteiller
mesh_terms: D003656:Decidua / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology*; D018448:Models, Immunological; D011247:Pregnancy; D011971:Receptors, Immunologic / Q000378:metabolism; D014327:Trophoblasts / Q000276:immunology
chemical_list: D006680:HLA Antigens; D011971:Receptors, Immunologic