Philadelphia chromosome positive essential thrombocythemia with dilated cardiomyopathy.
We report here an unusual case of a 30-year old male patient with essential thrombocythemia (ET) and dilated cardiomyopathy, who on further investigation was found to have Philadelphia chromosome positive (Ph+) cells in the bone marrow. The reverse transcriptase-polymerase chain reaction (RT-PCR) test on his peripheral blood leucocytes revealed b2a2 transcript of the bcr-abl fusion gene. Literature shows that the boundary line between Ph+ essential thrombocythemia and chronic myeloid leukemia (CML) is getting blurred day by day. Each one may be a part of the spectrum of a single clonal proliferative disease. Association of dilated cardiomyopathy with ET has not been reported.
Khandakar
M R
MR
Department of Medicine, Calcutta National Medical College, Kolkata, W.B.
Roy
K
K
Mukherjee
S
S
Talukdar
A
A
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D006801:Humans; D008297:Male; D010677:Philadelphia Chromosome; D013920:Thrombocythemia, Essential / Q000235:genetics*