Unraveling the chromosomal aberrations of head and neck squamous cell carcinoma: a review.
Information from the genetic analysis of head and neck cancer has grown enormously in the last 20 years. The advent of high-resolution genetic analysis techniques such as microarray technology will further expand this field in the future. Here we review the data on chromosomal aberrations of head and neck squamous cell carcinoma, focusing on the data generated by comparative genomic hybridization analysis, and suggest how such findings will be taken forward over the next decade. With the search engine PUBMED, the key words "comparative genomic hybridisation," "head and neck," "oral," "hypopharyngeal," "laryngeal," and "squamous cell carcinoma" were used. Publications unavailable in English were excluded.
Patmore
Harriet S
HS
Department of Surgery, Postgraduate Medical Institute in Association with Hull York Medical School, University of Hull Wolfson Building, Cottingham Road, Kingston Upon Hull, United Kingdom, HU6 7RX.
Cawkwell
Lynn
L
Stafford
Nicholas D
ND
Greenman
John
J
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization