title: Effects of ambient particulate matter on peak expiratory flow rates and respiratory symptoms of asthmatics during Asian dust periods in Korea.
abstract: OBJECTIVE
  Dust generating events frequently produce ambient dust particles that are less than 10 microm in diameter, and these have been linked to adverse effects in the general population. However, the evidence linking these particles to adverse effects on the airways of asthmatic individuals is limited. The objective of this study was to investigate the possible adverse effects of Asian dust events on the respiratory functions and symptoms of subjects with bronchial asthma.
  
  
  METHODS
  From March to June 2002, individuals were enrolled who had been diagnosed as having asthma by bronchial challenge or by their bronchodilator response. The patients were divided into three groups according to asthma severity: mild, moderate and severe. Patients with other major disease states were excluded. Patients completed twice-daily diaries monitoring PEF, respiratory symptoms, and daily activities. The daily and hourly mean levels of particulate matter <10 microm in diameter (PM(10)), as well as nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)), ozone (O(3)) and carbon monoxide (CO) were measured at 10 monitoring sites in Incheon, Korea.
  
  
  RESULTS
  Dust events occurred 14 times during the study period. On dusty days there were increased levels of PM(10), decreased levels of NO(2) and SO(2), and no change in the CO levels, compared to the levels on control days. An increase in PM(10) concentration was associated with increases in PEF variability of >20% (P<0.05), more night-time symptoms (P<0.05), and a decrease in the mean PEF (P<0.05), calculated by longitudinal data analysis. In contrast, there was no association between the PM(10) levels and bronchodilator inhaler use or daytime respiratory symptoms. Using a general additive Poisson regression model, a borderline association was noted between PM(10) and respiratory symptoms, with a relative risk of 1.05 (95% confidence interval (CI), 0.99--1.17). There was no association between the PM(10) concentrations and PEF measurements, with PEF variability of >20% between the morning and evening values and a relative risk of 1.05 (95% CI, 0.89--1.24) in all subjects.
  
  
  CONCLUSIONS
  This study provides evidence that Asian dust events are impacting on the respiratory symptoms of subjects with bronchial asthma, and ambient air pollution, particularly elevated PM(10), might be one of the aggravating factors.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gachon Medical School, Gil Medical Center, Incheon, Korea. jwpark@gilhospital.com
authors.forename: Jeong Woong
authors.initials: JW
authors.lastname: Park
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Lim
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kyung
authors.forename: Chang Hyeok
authors.initials: CH
authors.lastname: An
authors.forename: Sang Pyo
authors.initials: SP
authors.lastname: Lee
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Jeong
authors.forename: Young-Su
authors.initials: YS
authors.lastname: Ju
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis*; D001249:Asthma / Q000150:complications / Q000503:physiopathology*; D002248:Carbon Monoxide / Q000009:adverse effects / Q000032:analysis; D004391:Dust / Q000032:analysis*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000009:adverse effects / Q000032:analysis; D010126:Ozone / Q000009:adverse effects / Q000032:analysis; D010316:Particle Size; D010366:Peak Expiratory Flow Rate; D012120:Respiration Disorders / Q000209:etiology* / Q000503:physiopathology; D013458:Sulfur Dioxide / Q000009:adverse effects / Q000032:analysis
chemical_list: D000393:Air Pollutants; D004391:Dust; D013458:Sulfur Dioxide; D010126:Ozone; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide