In vitro activity and killing effect of uperin 3.6 against gram-positive cocci isolated from immunocompromised patients.
The in vitro activity of uperin 3.6, alone or combined with six antibiotics, against gram-positive cocci, including Rhodococcus equi, methicillin-resistant staphylococci, and vancomycin-resistant enterococci, was investigated. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline.
Giacometti
Andrea
A
Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
Cirioni
Oscar
O
Kamysz
Wojciech
W
Silvestri
Carmela
C
Licci
Alberto
A
D'Amato
Giuseppina
G
Nadolski
Piotr
P
Riva
Alessandra
A
Lukasiak
Jerzy
J
Scalise
Giorgio
G
D029845:Amphibian Proteins / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004357:Drug Synergism; D016983:Enterococcus / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects*; D016867:Immunocompromised Host; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology*; D016929:Rhodococcus equi / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D020713:Vancomycin Resistance
D029845:Amphibian Proteins; D000900:Anti-Bacterial Agents; D010455:Peptides; C121472:uperin 3.6 peptide, Uperoleia mjobergii; D017291:Clarithromycin; D004318:Doxycycline