rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease.
The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.
Koch
G
G
Fondazione Santa Lucia, IRCCS, Rome, Italy. Giakoch@libero.it
Brusa
L
L
Caltagirone
C
C
Peppe
A
A
Oliveri
M
M
Stanzione
P
P
Centonze
D
D
D000368:Aged; D001058:Apomorphine / Q000009:adverse effects*; D004298:Dopamine / Q000502:physiology; D018491:Dopamine Agonists / Q000009:adverse effects; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology* / Q000503:physiopathology; D009434:Neural Pathways / Q000502:physiology / Q000503:physiopathology; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology; D020127:Recovery of Function / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome
D018491:Dopamine Agonists; D001058:Apomorphine; D004298:Dopamine