title: Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy.
abstract: OBJECTIVE
  Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid.
  
  
  METHODS
  In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed.
  
  
  RESULTS
  In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7 microl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset.
  
  
  CONCLUSIONS
  Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.
authors.affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan.
authors.forename: C-C
authors.initials: CC
authors.lastname: Tsai
authors.forename: H-C
authors.initials: HC
authors.lastname: Kau
authors.forename: H-H
authors.initials: HH
authors.lastname: Tsai
authors.forename: S-C
authors.initials: SC
authors.lastname: Kao
authors.forename: W-M
authors.initials: WM
authors.lastname: Hsu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005123:Eye / Q000098:blood supply*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D049970:Graves Ophthalmopathy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone; D008775:Methylprednisolone