title: Effect of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm.
abstract: Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 63-year-old man with bleeding tendency and a large palpable abdominal aortic aneurysm (AAA) was diagnosed as having fibrinolysis dominant DIC by the excessive activation of both coagulation and fibrinolysis (plasmin -alpha2 plasmin inhibitor complex concentration is usually >4 microg/ml). Although several treatments were tried, DIC could not be controlled until the patient was given combined therapy of danaparoid (1,250 U/12 h, bolus IV) and tranexamic acid (0.5 g x 3/day, oral administration). This therapy may be beneficial when control for bleeding is required without restricting the ambulatory movement of patients by continuous drip.
authors.affiliation: Department of Internal Medicine (III), Kanazawa University School of Medicine, Kanazawa, Japan. ontachiy@med3.m.kanazawa-u.ac.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ontachi
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.forename: Masahisa
authors.initials: M
authors.lastname: Arahata
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kadohira
authors.forename: Mio
authors.initials: M
authors.lastname: Maekawa
authors.forename: Tomoe
authors.initials: T
authors.lastname: Hayashi
authors.forename: Masahide
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Morishita
authors.forename: Masanori
authors.initials: M
authors.lastname: Saito
authors.forename: Shinji
authors.initials: S
authors.lastname: Minami
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D017544:Aortic Aneurysm, Abdominal / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D003871:Dermatan Sulfate / Q000008:administration & dosage*; D004211:Disseminated Intravascular Coagulation / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D006497:Heparan Sulfate / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006497:Heparan Sulfate; D014148:Tranexamic Acid; C035838:danaparoid