Total assignment of the (1)H- and (13)C-NMR spectra for TZT-1027 and related compounds.
The total assignment of the (1)H- and (13)C-NMR spectra for TZT-1027 was carried out using various NMR methods (1D, 2D NMR). It was found that TZT-1027 exists in two different conformations resulting from the cis-trans isomerization of the amide bond at N-11 and C-12 in DMSO-d(6). The (1)H- and (13)C-NMR spectra of compound 1 and 2 comprised of the partial structure of TZT-1027 were also assigned to be TZT-1027. These assignments showed that compound 1 is in good agreement with TZT-1027 with regard to formation of the conformers.
Uchida
Hiroshi
H
Teikoku Hormone Mfg. Co., Ltd.; 1604 Shimosakunobe, Takatsu-ku, Kawasaki, Kanagawa 213-8522, Japan. uchida-h@teikoku-hormone.co.jp
Nishiyama
Takashi
T
Keino
Katsuyuki
K
Seki
Toshimi
T
Miyazaki
Koichi
K
Shiraiwa
Masafumi
M
D000970:Antineoplastic Agents / Q000737:chemistry*; D004121:Dimethyl Sulfoxide; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*
D000970:Antineoplastic Agents; D009842:Oligopeptides; C105791:soblidotin; D004121:Dimethyl Sulfoxide