title: Shake it, don't break it: positive feedback and the evolution of oscillator design.
abstract: In cell cycle control, a negative feedback oscillator design is shown to be reinforced with a positive feedback loop, giving a robust oscillatory architecture that is surprisingly common in biology.
authors.affiliation: The Rockefeller University, New York, New York 10021, USA.
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Cross
authors.forename: Eric D
authors.initials: ED
authors.lastname: Siggia
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D016213:Cyclins / Q000378:metabolism; D025461:Feedback, Physiological / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D014981:Xenopus
chemical_list: D018797:Cell Cycle Proteins; D016213:Cyclins; D016203:CDC2 Protein Kinase