Gymnoascolides A-C: aromatic butenolides from an Australian isolate of the soil ascomycete Gymnoascus reessii.
Three new aromatic butenolides, gymnoascolides A-C (1-3), have been isolated from the Australian soil ascomycete Gymnoascus reessii and assigned structures on the basis of detailed spectroscopic analysis. The absolute configurations of gymnoascolides B (2) and C (3) at C-5 were solved using a combination of chemical derivatization and quantum chemical simulations.
Clark
Ben
B
Centre for Molecular Biodiversity, Institute for Molecular Biosciences, University of Queensland, St. Lucia, Queensland 4072, Australia.
Capon
Robert J
RJ
Lacey
Ernest
E
Tennant
Shaun
S
Gill
Jennifer H
JH
Bulheller
Benjamin
B
Bringmann
Gerhard
G
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001315:Australia; D001412:Bacillus subtilis / Q000187:drug effects; D006189:Haemonchus / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012988:Soil Microbiology
D000935:Antifungal Agents; C504388:gymnoascolide A; C504387:gymnoascolide B; C504389:gymnoascolide C; D015107:4-Butyrolactone