Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis.
OBJECTIVE
Adiponectin is a novel adipocytokine of extreme importance for the metabolism. Recent studies have indicated that adiponectin suppresses inflammation, angiogenesis, and fibrosis, which are central pathogenic factors for endometriosis. We addressed the possibility that adiponectin is implicated in endometriosis.


METHODS
We measured concentrations of adiponectin in peritoneal fluid (PF) of women with (n = 54) or without (n = 26) endometriosis using specific enzyme-linked immunosorbent assay.


RESULTS
Adiponectin concentrations in PF of women with endometriosis were significantly lower than those of women without endometriosis. With respect to the stages of the disease, the concentrations of adiponectin in women with stage III/IV endometriosis were significantly lower compared to those in women without endometriosis and with stage I/II endometriosis. Body mass index were comparable among the groups.


CONCLUSIONS
These findings imply that adiponectin may be an anti-endometriotic factor, possibly due to its anti-inflammatory, anti-angiogenic, and anti-fibrotic properties.
Takemura
Yuri
Y
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Osuga
Yutaka
Y
Harada
Miyuki
M
Hirata
Tetsuya
T
Koga
Kaori
K
Yoshino
Osamu
O
Hirota
Yasushi
Y
Morimoto
Chieko
C
Yano
Tetsu
T
Taketani
Yuji
Y
D052242:Adiponectin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D015992:Body Mass Index; D004715:Endometriosis / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism
D052242:Adiponectin