title: Esthesioneuroblastoma metastatic to the breast in a young woman.
abstract: BACKGROUND
  Metastases to the breast are rare and can be missed without knowledge of the clinical history. We report an unusual breast metastasis originating in an olfactory neuroblastoma.
  
  
  METHODS
  A breast metastasis from esthesioneuroblastoma occurred in a 20-year-old woman 2 years after the onset of the disease. The aspirates were hypercellular and composed of cellular aggregates and single cells with a monomorphic appearance. The cytoplasm was scanty and inconspicuous. The nucleus was large, with granular, hyperchromatic chromatin. Mitoses and apoptotic bodies were numerous. Because we were unaware of the past history at the time of the cytologic analysis, a definitive diagnosis was made only after pathologic study.
  
  
  CONCLUSIONS
  Esthesioneuroblastoma metastatic to the breast must be considered in the differential diagnosis of breast metastases. Fine needle aspiration, in conjunction with clinical information, can be effective in the diagnosis of esthesioneuroblastoma metastatic to the breast.
authors.affiliation: Department of Pathology, Salah Azaiez Institute, 1006 Bab Saadoun, Tunis, Tunisia. karima.mrad@rns.tn
authors.forename: Karima
authors.initials: K
authors.lastname: Mrad
authors.forename: Dhouha
authors.initials: D
authors.lastname: Mansouri
authors.forename: Maha
authors.initials: M
authors.lastname: Driss
authors.forename: Samia
authors.initials: S
authors.lastname: Sassi
authors.forename: Imene
authors.initials: I
authors.lastname: Abbes
authors.forename: Farhat
authors.initials: F
authors.lastname: Ben Ayed
authors.forename: Khaled
authors.initials: K
authors.lastname: Ben Romdhane
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009296:Nasal Cavity / Q000473:pathology*; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology