A phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive rats.
D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.
Hagiwara
Shin-Ya
SY
Three B Co., Inc., Nanporo, Japan.
Takahashi
Masayuki
M
Shen
Yanbo
Y
Kaihou
Shinobu
S
Tomiyama
Takahiro
T
Yazawa
Michio
M
Tamai
Yutaka
Y
Sin
Yoosu
Y
Kazusaka
Akio
A
Terazawa
Minoru
M
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D008353:Mannitol / Q000494:pharmacology*; D020076:Pleurotus / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR
D000806:Angiotensin-Converting Enzyme Inhibitors; D008353:Mannitol