The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds.
Hepatoblastoma is associated with familial adenomatous polyposis (FAP). In a series of 93 patients with hepatoblastoma,8 (8.6%) reported family histories suggestive of FAP. These and a review of reported FAP kindreds with hepatoblastoma may provide information helpful in counseling families with FAP.
Hirschman
Barbara A
BA
University of Texas Southwestern Medical Center, Department of Pediatrics, Macalester College, St. Paul, Minnesota, USA.
Pollock
Brad H
BH
Tomlinson
Gail E
GE
D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000235:genetics; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D017491:Genes, APC; D018197:Hepatoblastoma / Q000209:etiology*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009154:Mutation