title: A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes.
abstract: A highly efficient and practical approach for the synthesis of optically pure beta-amino alcohols by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes was developed. This method allows the preparation of a broad range of chiral beta-amino alcohols, including functionalized ones under mild conditions. It provides a straightforward access to enantiopure beta-amino alcohols that are widely applicable in asymmetric synthesis.
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
authors.forename: Yu-Wu
authors.initials: YW
authors.lastname: Zhong
authors.forename: Yi-Zhou
authors.initials: YZ
authors.lastname: Dong
authors.forename: Kai
authors.initials: K
authors.lastname: Fang
authors.forename: Kenji
authors.initials: K
authors.lastname: Izumi
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lin
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis*; D002073:Butanes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008956:Models, Chemical; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013441:Sulfinic Acids / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000605:Amino Alcohols; D002073:Butanes; D007097:Imines; D013441:Sulfinic Acids