Benzopyran, biphenyl, and tetraoxygenated xanthone derivatives from the twigs of Garcinia nigrolineata.
One new benzopyran, nigrolineabenzopyran A (1), two new biphenyls, nigrolineabiphenyls A and B (2, 3), and four new tetraoxygenated xanthones, nigrolineaxanthones T-W (4-7), were isolated from the crude methanol extract of the twigs of Garcinia nigrolineata along with 11 known xanthones. The xanthones isolated from the twigs as well as those from the stem bark were evaluated for antibacterial activity against methicillin-resistant Staphylococcus aureus. Nigrolineaxanthone F, latisxanthone D, and brasilixanthone showed significant activity, with an equal MIC value of 2 microg/mL.
Rukachaisirikul
Vatcharin
V
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand. vatcharin.r@psu.ac.th
Tadpetch
Kwanruthai
K
Watthanaphanit
Anyarat
A
Saengsanae
Neangnoi
N
Phongpaichit
Souwalak
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013785:Thailand; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D001713:Biphenyl Compounds; D044004:Xanthones; C504384:nigrolineabenzopyran A; C504385:nigrolineabiphenyl A; C504386:nigrolineabiphenyl B