Anti-alopecia effect of Gly-Leu-Phe, an immunostimulating peptide derived from alpha-lactalbumin.
Gly-Leu-Phe (GLF), an immunostimulating peptide derived from alpha-lactalbumin, prevented alopecia induced by an anticancer agent etoposide in a neonatal rat model after intraperitoneal injection at a dose of 100 mg/kg for 4 d or oral administration at a dose of 300 mg/kg for 6 d. By microscopic analysis of skin sections, GLF proved to inhibit etoposide-induced loss of hair, thickening of the epidermis, and thinning of the adipocyte layer. The anti-alopecia effect of GLF was inhibited by pyrilamine, a histamine H1 receptor antagonist, suggesting that the anti-alopecia effect is mediated by histamine release.
Tsuruki
Takahiro
T
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.
Yoshikawa
Masaaki
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000505:Alopecia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents / Q000009:adverse effects; D005047:Etoposide / Q000009:adverse effects; D007768:Lactalbumin / Q000737:chemistry*; D009842:Oligopeptides / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D009842:Oligopeptides; C062537:glycyl-leucyl-phenylalanine; D005047:Etoposide; D007768:Lactalbumin