title: Effects of filtering and delays on the estimates of a nonlinear respiratory mechanics model.
abstract: Estimation of mechanical properties of the respiratory system may be disturbed by instrumentation and physical set-up. The effects of lowpass filtering, filter mismatch and inter-channel delay in the digital converter are assessed on numerically simulated signals from a nonlinear model of the respiratory system. Large biases in model parameter estimates (up to about -300% for some parameters) were caused by these instrumental interferences and were reduced by including an inertance in the retrieved model. The results reinforce the importance of a careful evaluation of the instrumental set-up used in physiological measurements.
authors.affiliation: Biomedical Engineering Programme, Federal University of Rio de Janeiro, Graduate School of Engineering, PO Box 68510, 21945-970 Rio de Janeiro, RJ, Brazil. jandre@peb.ufrj.br
authors.forename: Frederico C
authors.initials: FC
authors.lastname: Jandre
authors.forename: Alysson Roncally Silva
authors.initials: AR
authors.lastname: Carvalho
authors.forename: Alexandre Visintainer
authors.initials: AV
authors.lastname: Pino
authors.forename: Antonio
authors.initials: A
authors.lastname: Giannella-Neto
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D000465:Algorithms; D001696:Biomechanical Phenomena / Q000295:instrumentation* / Q000379:methods; D003198:Computer Simulation; D008954:Models, Biological; D017711:Nonlinear Dynamics; D015656:Respiratory Mechanics / Q000502:physiology*