title: Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats.
abstract: We developed a transgenic (Tg) rat model that overexpresses human proadrenomedullin N-terminal 20 peptide (PAMP) only and then compared the effects of unilateral nephrectomy followed by a high salt diet for five weeks in Tg and wild-type rats. We found that systolic blood pressure was significantly lower in Tg UNX rats and cardiac hypertrophy and myocardial fibrosis was also attenuated in Tg rats. Evaluation of gene expression showed suppression of cardiac local renin-angiotensin system (RAS) in Tg rat. These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS.
authors.affiliation: First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, 5200 Kihara, Miyazaki 889-1692, Japan.
authors.forename: Yuan-Ning
authors.initials: YN
authors.lastname: Cao
authors.forename: Kenji
authors.initials: K
authors.lastname: Kuwasako
authors.forename: Johji
authors.initials: J
authors.lastname: Kato
authors.forename: Kensaku
authors.initials: K
authors.lastname: Nishihira
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Asada
authors.forename: Tanenao
authors.initials: T
authors.lastname: Eto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D053607:Adrenomedullin; D000818:Animals; D030801:Animals, Genetically Modified; D001794:Blood Pressure / Q000502:physiology*; D006332:Cardiomegaly / Q000378:metabolism / Q000473:pathology*; D004032:Diet; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007668:Kidney / Q000166:cytology / Q000473:pathology; D009206:Myocardium / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism*; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D012084:Renin-Angiotensin System / Q000502:physiology; D012492:Salts / Q000008:administration & dosage; D019076:Transgenes
chemical_list: D010446:Peptide Fragments; D011498:Protein Precursors; D011506:Proteins; D012492:Salts; C088633:proadrenomedullin; D053607:Adrenomedullin