Acquired hemophilia A: a concise review.
Acquired hemophilia A is a rare but severe autoimmune bleeding disorder. It is more frequent in the elderly and results from the presence of autoantibodies directed against clotting factor VIII. In this review, we briefly report on the present state of knowledge regarding acquired hemophilia A, analyzing its epidemiology, pathogenesis, diagnostic, and clinical features. We also describe the main characteristics of this disorder according to its association with different conditions and the most important advances in the treatment of bleeding episodes and the eradication of the autoantibody.
Franchini
Massimo
M
Servizio di Immunoematologia e Trasfusione--Centro Emofilia, Azienda Ospedaliera di Verona, Italy. mfranchini@mail.univr.it
Gandini
Giorgio
G
Di Paolantonio
Tiziana
T
Mariani
Guglielmo
G
D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases; D005169:Factor VIII / Q000276:immunology; D006467:Hemophilia A / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D006801:Humans
D001323:Autoantibodies; D005169:Factor VIII