title: Two new meroterpenoids, penisimplicin A and B, isolated from Penicillium simplicissimum.
abstract: In the course of our research for new antifungal agents, two new meroterpenoids, penisimplicin A (1) and B (2), were isolated from Penicillium simplicissimum. The absolute structures of 1 and 2 were established by spectroscopic and chemical investigation. Penisimplicin A (1) and B (2) are rare examples of D-ring seco-meroterpenoids. Since compounds 1 and 2 showed no antifungal activities, the isolation of the compounds with antifungal activity will be attempted.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University; 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Shin-Ichirou
authors.initials: S
authors.lastname: Komai
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itabashi
authors.forename: Koohei
authors.initials: K
authors.lastname: Nozawa
authors.forename: Kaoru
authors.initials: K
authors.lastname: Okada
authors.forename: Galba Maria de
authors.initials: GM
authors.lastname: Campos Takaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yaguchi
authors.forename: Kayoko
authors.initials: K
authors.lastname: Takizawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Fukushima
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D001894:Borohydrides; D002236:Carbohydrate Conformation; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D006868:Hydrolysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D001894:Borohydrides; D007202:Indicators and Reagents; C025364:sodium borohydride; D000432:Methanol