title: Efficient pd-catalyzed amination of heteroaryl halides.
abstract: The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine. [reaction: see text]
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Charles
authors.forename: Phillip
authors.initials: P
authors.lastname: Schultz
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry
chemical_list: D006846:Hydrocarbons, Halogenated; D010720:Phosphines; D011743:Pyrimidines; D010165:Palladium