title: CpG oligodeoxynucleotides increase the susceptibility of normal mice to infection by Candida albicans.
abstract: Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.
authors.affiliation: Section of Retroviral Immunology, CBER/FDA, Bethesda, MD 20892, USA.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ito
authors.forename: Joao
authors.initials: J
authors.lastname: Pedras-Vasconcelos
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Klinman
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000378:metabolism / Q000401:mortality; D018899:CpG Islands / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D007113:Immunity, Innate; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D018664:Interleukin-12 / Q000096:biosynthesis / Q000378:metabolism; D051379:Mice; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D007166:Immunosuppressive Agents; D009838:Oligodeoxyribonucleotides; D018664:Interleukin-12