[The expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma].
OBJECTIVE
To study the expression and correlation of eIF4E and VEGF in laryngeal squamous cell carcinoma (LSCC).


METHODS
Western-blot analysis was performed on tumor core,transition core, "tumor-free" core of 20 specimens of fresh LSCC by using anti-eIF4E and VEGF antiserums.


RESULTS
The expression of eIF4E protein level from "tumor-free" core, transition core and tumor core of LSCC appeared progressive overexpression. It appeared that there was significant elevation of VEGF protein level in tumor core compared with tumor transition and "tumor-free" core. There appeared to be statistically significantly correlation of eIF4E and VEGF expression.


CONCLUSIONS
Overexpression of eIF4E may be a molecular marker of malignant transformation and progression. The overexpression of VEGF is highly associated with the growth and metastasis of LSCC, and may be of prognostic value. The correlation of eIF4E and VEGF may serve as a potential target for antiangiogenic therapy of LSCC.
Wang
Binquan
B
Department of Otolaryngology, the First Hospital of Shanxi Medical University, Taiyuan, 030001, China. wbqxx@public.ty.sx.cn
Zhang
Haili
H
Chen
Yanqiu
Y
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D039561:Eukaryotic Initiation Factor-4E; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A