title: Animal models of renal fibrosis.
abstract: Most of the present knowledge on pathomechanism of renal fibrosis is based on experimental studies with laboratory animals. Today, a variety of genetic and inducible animal models that mimic primary causes of human disease such as diabetes mellitus, glomerulonephritis, or lupus erythematodes are available. However, only few of these models progress consistently to interstitial fibrosis in the kidney involving interestitial fibrosis, tubular atrophy, and glomerulosclerosis, which are common features of renal fibrogenesis. In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Zeisberg
authors.forename: Mary A
authors.initials: MA
authors.lastname: Soubasakos
authors.forename: Raghu
authors.initials: R
authors.lastname: Kalluri
mesh_terms: D000818:Animals; D001284:Atrophy; D001324:Autoantigens; D001485:Basement Membrane / Q000473:pathology; D024141:Collagen Type IV / Q000172:deficiency; D004247:DNA / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D005355:Fibrosis / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology*; D005838:Genotype; D005921:Glomerulonephritis / Q000175:diagnosis; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology*; D051379:Mice; D009393:Nephritis / Q000175:diagnosis; D009394:Nephritis, Hereditary; D009395:Nephritis, Interstitial / Q000175:diagnosis; D016133:Polymerase Chain Reaction; D014524:Urethral Obstruction / Q000175:diagnosis
chemical_list: D001324:Autoantigens; D024141:Collagen Type IV; C057112:type IV collagen alpha3 chain; D004247:DNA