title: Maternal suicidality and risk of suicidality in offspring: findings from a community study.
abstract: OBJECTIVE
  This study evaluated the associations between suicidal ideation and suicide attempts in mothers and various aspects of suicidality in their offspring in a representative community sample.
  
  
  METHODS
  Baseline and 4-year follow-up data were used from the Early Developmental Stages of Psychopathology study, a prospective, longitudinal community study of adolescents and young adults. Results are based on 933 adolescents who completed follow-up and for whom direct diagnostic information for the biological mother was available. Suicidal ideation and suicide attempts were assessed in adolescents and mothers with the Munich-Composite International Diagnostic Interview.
  
  
  RESULTS
  Compared to offspring of mothers without suicidality, offspring of mothers reporting suicide attempts showed a remarkably higher risk for suicidal thoughts and suicide attempts and a tendency toward suicide attempts at an earlier age. Associations were comparable for male and female offspring. Transmission of maternal suicidality was roughly stable with control for maternal comorbid psychopathology.
  
  
  CONCLUSIONS
  The offspring of mothers with suicide attempts are at a markedly increased risk for suicidality themselves and tend to manifest suicide attempts earlier than offspring of mothers without suicidality. Suicidality seems to run in families, independent of depression and other psychopathology.
authors.affiliation: Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology Unit, Kraepelinstr. 2, 80804 München, Germany. lieb@mpipsykl.mpg.de
authors.forename: Roselind
authors.initials: R
authors.lastname: Lieb
authors.forename: Thomas
authors.initials: T
authors.lastname: Bronisch
authors.forename: Michael
authors.initials: M
authors.lastname: Höfler
authors.forename: Andrea
authors.initials: A
authors.lastname: Schreier
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Wittchen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002593:Cetrimonium Compounds; D016241:Child of Impaired Parents / Q000523:psychology* / Q000706:statistics & numerical data; D015897:Comorbidity; D003625:Data Collection / Q000706:statistics & numerical data; D003866:Depressive Disorder / Q000453:epidemiology / Q000523:psychology; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000523:psychology; D008875:Middle Aged; D009035:Mothers / Q000523:psychology*; D009226:Myristates; D009539:Nicotinic Acids; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012841:Simethicone; D013229:Stearic Acids; D013405:Suicide / Q000523:psychology* / Q000706:statistics & numerical data; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data
chemical_list: D002593:Cetrimonium Compounds; D004338:Drug Combinations; D009226:Myristates; D009539:Nicotinic Acids; D013229:Stearic Acids; C058060:Prevasore; D012841:Simethicone