Double-dose ivermectin vs albendazole for the treatment of gnathostomiasis.
A comparative study was performed for the treatment of gnathostomiasis patients with ivermectin 0.2 mg/kg for 2 days in 15 patients vs albendazole 400 mg twice daily for 21 days in 14 patients. The ivermectin and albendazole gave cure rates of 100% and 78.5%, respectively, however the difference was not statistically significant between the two drugs (Fisher's exact, p=0.0996). One year after treatment, the patients who had no migratory swellings and a drop in ELISA titers or a negative immunoblot test were considered to be cured. The side effect of ivermectin for two days was dizziness. The side effects of albendazole were nausea, dizziness, and an increased alkaline phosphatase.
Nontasut
Ponganant
P
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Claesson
Bo A
BA
Dekumyoy
Paron
P
Pakdee
Wallop
W
Chullawichit
Sukvannee
S
D015766:Albendazole / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000009:adverse effects; D000977:Antiparasitic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils; D006039:Gnathostoma / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage* / Q000009:adverse effects; D017205:Spirurida Infections / Q000097:blood / Q000188:drug therapy*; D013785:Thailand; D016896:Treatment Outcome
D000871:Anthelmintics; D000977:Antiparasitic Agents; D007559:Ivermectin; D015766:Albendazole