[Maternal serum lipid at 36-42 weeks' gestation and their relationship to newborn weight in pregnant women with gestational diabetes mellitus and type 1 and type 2 diabetes mellitus].
OBJECTIVE
To investigate the levels of serum lipid at 36 - 42 weeks' gestation and their relationship to newborn weight in pregnant women with gestational diabetes mellitus (GDM) and type 1 and type 2 diabetes mellitus (DM).


METHODS
This study included 30 normal pregnant women, 40 patients with GDM, 30 patients with type 1 DM and 30 with type 2 DM. Subjects with complications including hypertension or thyreogenic diseases were excluded. Fasting serum triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured by enzymatic method.


RESULTS
(1) Serum triglyceride levels in pregnant women with GDM, type 1 DM, type 2 DM and normal controls were (4.0 +/- 1.4) mmol/L, (2.9 +/- 0.8) mmol/L, (4.1 +/- 2.5) mmol/L and (2.7 +/- 0.9) mmol/L respectively; the total cholesterol levels were (6.5 +/- 3.0) mmol/L, (6.2 +/- 2.8) mmol/L, (6.4 +/- 3.2) mmol/L and (6.0 +/- 3.0) mmol/L respectively; low density lipoprotein cholesterol levels were (3.2 +/- 1.3) mmol/L, (3.2 +/- 1.3) mmol/L, (3.3 +/- 1.1) mmol/L and (3.2 +/- 1.0) mmol/L respectively; high density lipoprotein cholesterol levels were (1.6 +/- 0.5) mmol/L, (1.4 +/- 0.5) mmol/L, (1.5 +/- 0.4) mmol/L and (1.6 +/- 0.4) mmol/L respectively; the newborn weights were (4108 +/- 544) g, (3323 +/- 457) g, (4111 +/- 263) g, and (3463 +/- 516) g respectively. Triglyceride levels in pregnant women with GDM and type 2 DM were significantly higher than in normal controls and type 1 DM patients (P < 0.01). (2) Triglyceride levels correlated with birth weights independently (r = 0.39, P < 0.01).


CONCLUSIONS
Triglyceride levels at 36-42 weeks' gestation were elevated in pregnant women with GDM and type 2 DM, suggesting that they might have more obvious insulin resistance. In pregnant women with DM, a positive and significant correlation was found between triglyceride levels and newborn weights.
He
Bing
B
Department of Endocrinology, The Second Hospital Affiliated to China Medical University, Shenyang 110004, China.
Li
Shu-qin
SQ
Wang
Wei
W
Han
Ping
P
D000328:Adult; D001724:Birth Weight; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
D008055:Lipids