Vitamin E and prostate cancer: is vitamin E succinate a superior chemopreventive agent?
There is convincing evidence that vitamin E succinate significantly reduces human prostate cancer growth in experimental models compared with alpha-tocopherol or tocopheryl acetate. Its intact delivery to cancer cells is questionable when administered orally; however, a study in transgenic mice showed a synergistic inhibitory effect of dietary vitamin E succinate, selenium, and lycopene on prostate cancer incidence. Clinical trials have yet to confirm this effect.
Basu
Arpita
A
Department of Nutrition and Food Sciences, Texas Woman's University, P.O. Box 425888, Denton, TX 76204-5888, USA. arpita_twu@hotmail.com
Imrhan
Victorine
V
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D014810:Vitamin E; D024505:Tocopherols