title: Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2.
abstract: The binding of the norepinephrine transporter radioligand, (S,S)-[18F]FMeNER-D2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus>>cortex approximately cerebellum approximately thalamus>caudate approximately putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.
authors.affiliation: Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, S-17176 Stockholm, Sweden. magnus.schou@cns.ki.se
authors.forename: Magnus
authors.initials: M
authors.lastname: Schou
authors.forename: Christer
authors.initials: C
authors.lastname: Halldin
authors.forename: Victor W
authors.initials: VW
authors.lastname: Pike
authors.forename: P David
authors.initials: PD
authors.lastname: Mozley
authors.forename: David
authors.initials: D
authors.lastname: Dobson
authors.forename: Robert B
authors.initials: RB
authors.lastname: Innis
authors.forename: Lars
authors.initials: L
authors.lastname: Farde
authors.forename: Håkan
authors.initials: H
authors.lastname: Hall
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D001344:Autopsy; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003891:Desipramine / Q000494:pharmacology; D000068736:Duloxetine Hydrochloride; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D009025:Morpholines / Q000493:pharmacokinetics*; D011180:Postmortem Changes; D011869:Radioligand Assay; D013876:Thiophenes / Q000494:pharmacology
chemical_list: C506462:2-(alpha-(2-fluoromethoxyphenoxy)benzyl)morpholine; D018759:Adrenergic Uptake Inhibitors; D005462:Fluorine Radioisotopes; D009025:Morpholines; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride; D003891:Desipramine