First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation.
Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation. A 12-month-old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. Forty months after transplantation, he developed acute myeloid leukemia. Cytogenetic and molecular analysis confirmed donor cell origin. The Cord Blood Bank (CBB) contacted the donor's family and established that the child, now 7 years old, was healthy. This represents the first reported case of donor cell leukemia following UCBT. This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients.
Fraser
Christopher J
CJ
Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA. frase081@umn.edu
Hirsch
Betsy A
BA
Dayton
Vanessa
V
Creer
Michael H
MH
Neglia
Joseph P
JP
Wagner
John E
JE
Baker
K Scott
KS
D000208:Acute Disease; D001782:Blood Donors; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D003582:Cytogenetics; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D008297:Male; D014470:Umbilical Cord