Cerebral solitary Langerhans cell histiocytosis: report of two cases and review of the literature.
Cerebral solitary Langerhans cell histiocytosis (LCH) is a very uncommon condition. We describe two new cases: a 30-year-old man with seizures and a tumour in the left frontal lobe, which was composed of a polymorphic infiltrate with a predominance of histiocytes and eosinophils; and a 65-year-old man with headaches and dysarthria, with a left parietal tumour, which showed a diffuse proliferation of histiocytic cells and areas of necrosis. In both cases, the histiocytes were strongly positive for S-100 and CD1a, and Birbeck's granules were demonstrated by electron microscopy in the first case. Both patients underwent a complete excision of their lesions. The second patient received additional postoperative radiotherapy. They were asymptomatic after 26 and 27 months, respectively. It seems that cerebral solitary LCH is a clinicopathological entity with a good outcome. Only 15 cases of this rare process have been previously reported in the English literature.
Rodríguez-Pereira
C
C
Department of Pathology, Hospital General de Castellón, Castellón, Spain.
Borrás-Moreno
J M
JM
Pesudo-Martínez
J V
JV
Vera-Román
J M
JM
D000328:Adult; D000368:Aged; D018949:Antigens, CD1 / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D009418:S100 Proteins / Q000378:metabolism; D016896:Treatment Outcome
D018949:Antigens, CD1; D009418:S100 Proteins