Murine microglia are effective phagocytes for Borrelia burgdorferi.
Lyme disease is a multi-systemic infection that causes diverse neurologic dysfunction collectively known as neuroborreliosis. In the murine model of Lyme disease, Borrelia burgdorferi are seldom found in the nervous system indicating that the spirochetes are rapidly cleared from the brain and peripheral nerves. In the present study, we examined the interaction between microglia and B. burgdorferi. Murine microglia are efficient phagocytes and are capable of ingesting and killing spirochetes with or without opsonization.
Kuhlow
Christopher J
CJ
Center for Infectious Diseases, SUNY at Stony Brook, Stony Brook, New York 11794-5120, USA.
Garcia-Monco
Juan C
JC
Coleman
James L
JL
Benach
Jorge L
JL
D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D001428:Bacterial Vaccines; D025065:Borrelia burgdorferi; D056668:Cathepsin L; D002403:Cathepsins / Q000378:metabolism; D002470:Cell Survival; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005455:Fluorescent Antibody Technique / Q000379:methods; D008074:Lipoproteins / Q000378:metabolism; D008193:Lyme Disease / Q000382:microbiology / Q000473:pathology*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D017628:Microglia / Q000502:physiology*; D010586:Phagocytes / Q000502:physiology*; D013997:Time Factors; D033921:Vesicular Transport Proteins
D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; D008565:Membrane Proteins; C072045:OspA protein; D033921:Vesicular Transport Proteins; C093846:early endosome antigen 1; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D056668:Cathepsin L; C534278:Ctsl protein, mouse