A mucin like gene different from the previously reported members of the mucin like gene families is transcribed in Trypanosoma cruzi but not in Trypanosoma rangeli.
Trypanosoma cruzi expresses mucin like glycoproteins encoded by a complex multigene family. In this work, we report the transcription in T. cruzi but not in T. rangeli of a mucin type gene automatically annotated by the T. cruzi genome project. The gene showed no nucleotide similarities with the previously reported T. cruzi mucin like genes, although the computational analysis of the deduced protein showed that it has the characteristic features of mucins: a signal peptide sequence, O-glycosylation sites, and glycosylphosphatidylinositol (GPI) anchor sequence. The presence in this gene of N-terminal and C-terminal coding sequences common to other annotated mucin like genes suggests the existence of a new mucin like gene family.
Abate
Teresa
T
Instituto de Medicina Tropical Dr. Félix Pifano, Caracas 1041-A, DF, Venezuela. abatet@ucv.ve
Rincón
Mónica
M
Díaz-Bello
Zoraida
Z
Spencer
Lilian
L
Rodríguez-Acosta
Alexis
A
D000818:Animals; D001483:Base Sequence; D017125:Genes, Protozoan / Q000235:genetics*; D015698:Genomic Library; D008969:Molecular Sequence Data; D009077:Mucins / Q000235:genetics*; D014349:Trypanosoma cruzi / Q000235:genetics*
D009077:Mucins