Synthesis of the tetrahydroisoquinoline alkaloid (+/-)-renieramycin G and A (+/-)-lemonomycinone analogue from a common intermediate.
The total synthesis of tetrahydroisoquinoline alkaloids (+/-)-renieramycin G (4) and a lemonomycinone analogue (7) is described. A general strategy to synthesize both the mono- and bistetrahydroisoquinoline alkaloids from a common advanced intermediate, 17, is presented.
Magnus
Philip
P
Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712.
Matthews
Kenneth S
KS
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
D000470:Alkaloids; D044005:Tetrahydroisoquinolines; C507293:lemonomycinone; C507294:renieramycin G