Pursaethosides A-E, triterpene saponins from Entada pursaetha.
Five new triterpenoid saponins, pursaethosides A-E (1-5), were isolated from the n-BuOH extract of the seed kernels of Entada pursaetha along with the known phaseoloidin. The structures of 1-5 were elucidated mainly by spectroscopic data interpretation and chemical degradation. Pursaethosides C-E (3-5) possess as a common structural feature entagenic acid as aglycon, which is rare among triterpene saponins. Compounds 2-4 and phaesolidin were found to be not cytotoxic when tested against HCT 116 and HT-29 human colon cancer cells.
Tapondjou
Azefack Léon
AL
Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, UMIB EA3660, Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d'Arc, BP 87900, F-21079, Dijon Cedex, France.
Miyamoto
Tomofumi
T
Mirjolet
Jean-François
JF
Guilbaud
Nicolas
N
Lacaille-Dubois
Marie-Aleth
MA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002163:Cameroon; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D031298:Mimosa / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes