Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa.
Racemic diisophorone (500 mg) was converted by Cephalosporium aphidicola and Neurospora crassa over 10 days at 25 degrees C to 8beta-hydroxydiisophorone in yields of 10% (52 mg) and 20% (103 mg), respectively. The structure was established by IR, specific rotation, mass spectral, 1D and 2D-NMR studies.
Kiran
Ismail
I
Department of Chemistry, Osmangazi University, 26480, Eskinşehir, Turkey. ikiran@ogu.edu.tr
Akar
Tamer
T
Gorgulu
Asli
A
Kazaz
Cavit
C
D000164:Acremonium / Q000254:growth & development*; D001711:Biotransformation; D003512:Cyclohexanones / Q000378:metabolism*; D009492:Neurospora crassa / Q000254:growth & development*; D013237:Stereoisomerism
D003512:Cyclohexanones; C005940:isophorone