title: Enhancement of immune responses to an HBV DNA vaccine by electroporation.
abstract: These studies document the ability of electroporation (EP)-based DNA vaccination to induce multi-specific CTL responses to hepatitis B virus (HBV) DNA vaccination in normal mice and marked immune responses to multivalent HBV DNA immunization in larger animal species. These results suggest that electroporation-mediated HBV DNA vaccination is worth pursuing as a treatment for chronic HBV infection.
authors.affiliation: Ichor Medical Systems, 6310 Nancy Ridge Drive, Ste 107, San Diego, CA 92121, USA. aluxembourg@ichorms.com
authors.forename: A
authors.initials: A
authors.lastname: Luxembourg
authors.forename: D
authors.initials: D
authors.lastname: Hannaman
authors.forename: B
authors.initials: B
authors.lastname: Ellefsen
authors.forename: G
authors.initials: G
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Bernard
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis; D018274:Electroporation; D017325:Hepatitis B Vaccines / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D017325:Hepatitis B Vaccines; D019444:Vaccines, DNA