Structure and oxidation capacity of amino acid chloramine derivatives and their effects on platelet aggregation.
Comparison of antiaggregation capacity of N-chloramine acids with different position of the chloramine group in the molecule showed that in the most efficient compounds the distance between the chloramine and carboxyl groups was 3-5 carbon atoms. This feature of antiaggregation activity was not related to the difference in oxidation capacity of N-chloramine acids. It was hypothesized that the revealed structural dependence of antiaggregation activity of N-chloramine acids is determined by the structure of platelet membrane, in particular, the presence of a negatively charged group near the site of interaction between N-chloramine acids and platelet membrane.
Murina
M A
MA
Research Institute of Physicochemical Medicine, Ministry of Health of Russia, Moscow. marina_murina@mail.ru
Chudina
N A
NA
Roshchupkin
D I
DI
Belakina
N S
NS
Sergienko
V I
VI
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D002700:Chloramines / Q000737:chemistry* / Q000494:pharmacology*; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D011817:Rabbits
D000596:Amino Acids; D002700:Chloramines; D010975:Platelet Aggregation Inhibitors; C030816:chloramine