title: Breast myeloma: a report of 3 cases with fine needle aspiration cytologic findings.
abstract: BACKGROUND
  Multiple myeloma of the breast is very rare, and the fine needle aspiration (FNA) findings have not been reported before.
  
  
  METHODS
  Two cases of multiple myeloma presented with bilateral breast nodules during treatment with chemotherapy. One case of multiple myeloma presented initially with a left breast mass. FNA smears of all 3 cases revealed numerous plasma cells, plasmablasts and multinucleated giant plasma cells. The smears were diagnosed as plasma cell tumors. Serum immunoelectrophoresis revealed IgG myeloma in 2 cases and IgA myeloma in 1. Marrow aspirates revealed > 30% plasma cells. Two patients died, and 1 was alive at this writing.
  
  
  CONCLUSIONS
  The aspiration cytology findings of myeloma can be confuse, with primary and secondary tumors of the breast. The previous clinical history and ancillary studies, such as bone marrow study and serum immunoelectrophoresis, are essential to the correct diagnosis.
authors.affiliation: Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. kumarv@sums.ac.ir
authors.forename: Perikala V
authors.initials: PV
authors.lastname: Kumar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Vasei
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
authors.forename: Maryam
authors.initials: M
authors.lastname: Zakerinia
authors.forename: Mani
authors.initials: M
authors.lastname: Ramzi
authors.forename: Habib
authors.initials: H
authors.lastname: Noorani
authors.forename: Hadi
authors.initials: H
authors.lastname: Bagheri
authors.forename: Abdul Rasool
authors.initials: AR
authors.lastname: Talei
authors.forename: Hossein
authors.initials: H
authors.lastname: Soleimanpour
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D008327:Mammography; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D010954:Plasmacytoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology