[Hepatitis A seroprevalence in HIV-infected patients].
OBJECTIVE
The authors had for aim to prospectively study the hepatitis A seroprevalence of an HIV-infected population, followed-up in an outpatient clinic (CISIH Strasbourg).


METHODS
Blood tests were performed on all patients from September 2003 to March 2004 to screen for hepatitis A (total antibodies with Elisa).


RESULTS
The overall seroprevalence was 219/514 (56.6%), similar in male and female patients. It increased with age, especially in European patients (P = 0.003). The seroprevalence was lower in European subjects: 46.3% (while it reached 100% in sub-Saharan Africans), the prevalence was similar whatever the HIV risk group (46% in homosexual as well as in heterosexual patients, 44% in intravenous drug users). Hepatitis B or C co-infection did not increase the seroprevalence of hepatitis A. The hepatitis A seroprevalence was similar in various CD4 T cell count categories.


CONCLUSIONS
Our results stress the utility of hepatitis A serology in HIV-infected patients (more than 50% of European patients are non immune), and the importance of assessing hepatitis A vaccination.
Rey
D
D
Centre d'information et de soins de l'immunodéficience humaine, clinique médicale A, hôpitaux universitaires, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. david.rey@chru-strasbourg.fr
Frick-Michot
E
E
Partisani
M
M
Hess-Kempf
G
G
Cheneau
C
C
Priester
M
M
Bernard-Henry
C
C
de Mautort
E
E
Wendling
M J
MJ
Meyer
P
P
Lang
J M
JM
D000328:Adult; D017954:Africa South of the Sahara / Q000208:ethnology; D001208:Asia / Q000208:ethnology; D018791:CD4 Lymphocyte Count; D015897:Comorbidity; D005060:Europe / Q000208:ethnology; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006506:Hepatitis A / Q000453:epidemiology*; D035922:Hepatitis A Antibodies / Q000097:blood; D020010:Heterosexuality / Q000706:statistics & numerical data; D006716:Homosexuality / Q000706:statistics & numerical data; D006801:Humans; D016867:Immunocompromised Host; D007843:Latin America / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D065227:Transfusion Reaction
D035922:Hepatitis A Antibodies