title: Vaccine strategies of meningococcal disease: results of a 10-year population-based study.
abstract: Invasive meningococcal disease (IMD) is an important cause of morbidity and mortality in children and adults. This study was conducted to determine a possible increase in IMD in recent years with special interest focused on serogroup C disease. From January 1st 1993 to December 31st 2002, IMD was studied in one million residents of Austria. We used active, population-based surveillance data from the Office of Public Health. A total of 126 patients with positive blood and/or cerebrospinal fluid culture or positive swabs for Neisseria meningitidis were studied. The median age of all patients was 9.5 years (range 1 month to 63 years). The average incidence of all IMD subgroups was 1.05 cases per 100,000 person years and was highest in children 0-4 years old (7.08 cases per 100,000 person years) followed by young adults aged 15 to 19 years (4.35 cases per 100,000 person years). Serogroup C IMD occurred in 1.30 cases/100,000 person years in patients aged 0 to 4 years and in 1.92 cases/100,000 person years in patients aged 15 to 19 years. Overall mortality was 11.1%. There was a significant increase (P =0.001) in IMD due to serogroup B disease within the last 10 years. In contrast, serogroup C disease did not increase during the last decade.
  
  
  CONCLUSIONS
  Currently, we do not recommend mass vaccination against serogroup C disease in Austria, but young adults aged 15 to 19 years display a high incidence of meningococcal C disease. In this age group, vaccination against serogroup C disease should be considered.
authors.affiliation: Department of Paediatrics, Academic Teaching Hospital, Feldkirch, Austria. ariane.biebl@lkhf.at
authors.forename: Ariane
authors.initials: A
authors.lastname: Biebl
authors.forename: Gabriele
authors.initials: G
authors.lastname: Hartmann
authors.forename: Christian
authors.initials: C
authors.lastname: Bernhard
authors.forename: Elmar
authors.initials: E
authors.lastname: Bechter
authors.forename: Anita
authors.initials: A
authors.lastname: Luckner-Hornischer
authors.forename: Martin
authors.initials: M
authors.lastname: Frühwirth
authors.forename: Sigrid
authors.initials: S
authors.lastname: Heuberger
authors.forename: Felix
authors.initials: F
authors.lastname: Offner
authors.forename: Verena
authors.initials: V
authors.lastname: Barbieri
authors.forename: Burkhard
authors.initials: B
authors.lastname: Simma
mesh_terms: D000293:Adolescent; D000328:Adult; D001317:Austria / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D032541:Mass Vaccination; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D008875:Middle Aged; D038542:Neisseria meningitidis, Serogroup C; D012621:Seasons
chemical_list: D022401:Meningococcal Vaccines