title: Directionality of F-actin cables changes during the fission yeast cell cycle.
abstract: Longitudinal F-actin cables are thought to be important for transporting materials for polarized cell growth in fission yeast. We show that most F-actin in the cables is oriented such that the barbed end faces the nearest cell tip during interphase; however, this directionality is reversed during mitosis. These orientations of F-actin ensure proper transport of materials to growing sites during these cell-cycle stages.
authors.affiliation: Division of Biology, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 153-8902, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kamasaki
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Arai
authors.forename: Masako
authors.initials: M
authors.lastname: Osumi
authors.forename: Issei
authors.initials: I
authors.lastname: Mabuchi
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D000199:Actins / Q000378:metabolism* / Q000648:ultrastructure; D002453:Cell Cycle / Q000502:physiology*; D049108:Cell Enlargement; D016764:Cell Polarity / Q000502:physiology*; D046529:Microscopy, Electron, Transmission; D008938:Mitosis / Q000502:physiology*; D009218:Myosins / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D012568:Schizosaccharomyces / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D000199:Actins; D009218:Myosins