A mouse model for S. typhimurium-induced enterocolitis.
Salmonella typhimurium has emerged as a model pathogen that manipulates host cells in a complex fashion, thus causing disease. In humans, S. typhimurium causes acute intestinal inflammation. Intriguingly, type III secreted virulence proteins have a central role in this process. At the cellular level, the functions of these factors are well characterized; at present, animal models are required for elucidating how these factors trigger inflammatory disease in vivo. Calf infection models have been employed successfully and, recently, a mouse model was identified: in streptomycin-pretreated mice, S. typhimurium causes acute colitis. This mouse model provides a new avenue for research into acute intestinal inflammation because it enables the manipulation and dissection of both the bacterial and host contributions to the disease in unsurpassed detail.
Hapfelmeier
Siegfried
S
Institute of Microbiology, ETH Hönggerberg, Wolfgang-Pauli-Str. 10, 8093 Zürich, Switzerland.
Hardt
Wolf-Dietrich
WD
D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D004760:Enterocolitis / Q000382:microbiology*; D006801:Humans; D051379:Mice; D012480:Salmonella Infections / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D012486:Salmonella typhimurium