[Advances in researches on the relationship between single nucleotide polymorphism and prostate cancer].
Single nucleotide polymorphism (SNP) has been regarded as the third generation of heredity markers with many marked characteristics. It has been developed many new experimental techniques for detecting SNP in recent years, such as TaqMan probe technique, gene chip technique, denaturing high performance liquid chromatograph, matrix assisted laser desorption ionization-time off light mass spectrometry and minisequencing technique. Great progress has been made in researches on human tumors with SNP as heredity markers. This article reviews the genes and SNP related to the development of prostate cancer, including prostate specific antigen response component, enzymes, hormones and their receptors, cell cycle regulating protein, cytokines, adhesion molecules, vitamins and so on, and aims to explore the possible mechanism of the disease.
Wang
Shu-Kui
SK
Central Laboratory, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, China. Wsk_zzy@hotmail.com
Wang
Zi-Zheng
ZZ
Huang
Yu-Feng
YF
D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017430:Prostate-Specific Antigen / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*
D017430:Prostate-Specific Antigen