title: [Two patients with joint pain as initial presentation of a haematological malignancy].
abstract: A 75-year-old man and a 53-year-old woman had longstanding joint pain, for which they had been treated with NSAIDs. When the symptoms worsened, a thorough diagnostic investigation was conducted that revealed myeloproliferative bone-marrow disorders in both patients. The man, who had polyarticular gout secondary to chronic myelomonocytic leukaemia, was able to maintain control of his joint pain with medical treatment. In the woman, with a history of stable joint pain due to polyarthritis, deterioration of the symptoms and the development of pancytopaenia led to a diagnosis of acute lymphocytic leukaemia; she died after receiving multiple courses of chemotherapy. The possibility of an underlying malignancy should be considered in patients with atypical symptoms in the locomotor system, an unexpected course or anomalous secondary symptoms.
authors.affiliation: Atrium Medisch Centrum, afd. Reumatologie, H.Dunantstraat 5, 6419 PC Heerlen. artsassistent@atriummc.nl
authors.forename: F A
authors.initials: FA
authors.lastname: Meijer
authors.forename: H R M
authors.initials: HR
authors.lastname: Peeters
authors.forename: M J F
authors.initials: MJ
authors.lastname: Starmans-Kool
authors.forename: H
authors.initials: H
authors.lastname: van der Tempel
authors.forename: H H M L
authors.initials: HH
authors.lastname: Houben
mesh_terms: D000368:Aged; D018771:Arthralgia / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy