Effect of electrical stimulation of the reticular nucleus of the rat thalamus upon c-fos immunoreactivity in the retrosplenial cortex.
Electrical stimulation of the reticular nucleus of the rat thalamus results in activation of c-fos immunoreactivity in nerve cells of the ipsilateral retrosplenial cortex. The c-fos immunoreactive neurons are mainly concentrated in lamina IV of the retrosplenial cortex. Conversely, electrical stimulation of the retrosplenial cortex induced c-fos immunoreactivity in the ipsilateral reticular nucleus of the thalamus. The results of the electrical stimulation suggest a direct synaptic connection between the cerebral cortex and the ipsilateral reticular thalamic nucleus. Simultaneous immunohistochemical staining proves that the majority of nerve cells and dendro-dendritic terminals in the reticular thalamic nucleus contain parvalbumine and, at the same time, also GABA. The role of GABA-ergic parvalbumine immunoreactive terminals in the reticular thalamic nucleus seems to be related to integration and processing of impulses and attentional gating, distinguishing between noxious and innocuous inputs.
Knyihar-Csillik
Elizabeth
E
Department of Neurology, Albert Szent-Györgyi University Medical School, University of Szeged, 6, Semmelweis utca, 6701 Szeged, Hungary.
Chadaide
Zoltan
Z
Mihaly
Andras
A
Krisztin-Peva
Beata
B
Csillik
Bertalan
B
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013787:Thalamic Nuclei / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos