Determination of urinary Myo-/chiro-inositol ratios from Korean diabetes patients.
Of two major forms (myo- and chiro-inositol) of inositols, only chiro-inositol enhances the activity of proteins involved in intracellular glucose metabolism. This study aims to determine the urinary myo-/chiro-inositol ratio in type 1 and type 2 diabetes patients and compare its ratio with the normal control group. The 24-hour urinary myo- and chiro-inositols in 71 Korean diabetes patients and 39 control subjects have been quantified using high-performance liquid chromatography, and their ratios have been evaluated as indices of insulin resistance. The level of 24-hour urinary myo-inositol was significantly higher in both type 1 and type 2 diabetes than with the control group, whereas the urinary chiro-inositol in type 1 or type 2 diabetes was lower than that in normal subjects. The myo-/chiro-inositol ratio in diabetes patients was higher than that in the control group. Twenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance.
Jung
Tae-Sik
TS
Department of Internal Medicine, Gyeongsang National University, Jinju 660- 702, Korea.
Hahm
Jong-Ryeal
JR
Kim
Jong-Jin
JJ
Jung
Jung-Hwa
JH
Kang
Mi-Yeon
MY
Moon
Sung-Won
SW
Lee
Kang-Wan
KW
Kim
Ho-Cheol
HC
Lee
Jong-Deog
JD
Kim
Ji-Hye
JH
Kim
Deok-Ryong
DR
Chung
Soon-Il
SI
D000328:Adult; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D005260:Female; D006801:Humans; D007294:Inositol / Q000652:urine*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D007294:Inositol