[Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure].
OBJECTIVE
In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure.


METHODS
Twenty-four patients (mean age: 55+/-8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values.


RESULTS
Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolol treatment (p<0.05).


CONCLUSIONS
Metoprolol treatment can cause an improvement in transmitral and pulmonary venous flows.
Doğan
Sait Mesut
SM
Department of Cardiology, Medical Faculty, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey.
Aydin
Mustafa
M
Gürsürer
Metin
M
Dursun
Aydin
A
Cam
Fatih
F
Onuk
Tolga
T
Madak
Hediye
H
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001783:Blood Flow Velocity / Q000187:drug effects; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D008943:Mitral Valve / Q000187:drug effects* / Q000502:physiology; D011667:Pulmonary Veins / Q000187:drug effects* / Q000502:physiology; D011673:Pulsatile Flow / Q000187:drug effects; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol