Metaraminol (Aramine) in the management of a significant amlodipine overdose.
OBJECTIVE
To report a patient with a significant amlodipine self-poisoning who failed to clinically respond to conventional treatment and was managed with metaraminol (Aramine).


METHODS
A 43-year old male presenting after ingestion of 560 mg amlodipine, who failed to respond clinically to treatment with fluid resuscitation, calcium salts, glucagon and norepinephrine/epinephrine inotropic support.


RESULTS
Following a loading bolus of 2 mg and intravenous infusion (83 microg/min) of metaraminol (Aramine) there was improvement in his blood pressure, cardiac output and urine output.


CONCLUSIONS
This is the first case report of the beneficial use of metaraminol (aramine) in the management of significant amlodipine poisoning unresponsive to conventional therapy.
Wood
D M
DM
Pharmacology and Clinical Pharmacology, Department of Basic Medical Sciences, St George's Hospital Medical School, Jenner Wing, Cranmer Terrace, London SW17 ORE, UK. dwood@sghms.ac.uk
Wright
K D
KD
Jones
A L
AL
Dargan
P I
PI
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D017311:Amlodipine / Q000506:poisoning*; D002121:Calcium Channel Blockers / Q000506:poisoning*; D062787:Drug Overdose / Q000188:drug therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008680:Metaraminol / Q000627:therapeutic use*; D013406:Suicide, Attempted
D000316:Adrenergic alpha-Agonists; D002121:Calcium Channel Blockers; D017311:Amlodipine; D008680:Metaraminol