title: [Determination of acrylamide in heated starchy food by liquid chromatography-electrospray ionization tandem mass spectrometry].
abstract: An isotope dilution liquid chromatographic-electrospray ionization tandem mass spectrometric method has been established for the determination of acrylamide in heated starchy food with a C18 analytical column and methanol-water containing 0.1% formic acid (2:98, v/v) as mobile phases. The clean-up of samples was performed on an Oasis HLB solid phase extraction cartridge. The calibration curve of acrylamide showed good linearity in the range of 10-500 microg/L with correlation coefficient of 0.9995. The detection limit of the method was 6 microg/kg (S/N = 3), and the limit of quantification was 20 microg/kg (S/N = 10). The average recoveries at three levels ranged from 96.8% to 97.4% (n = 5), and the relative standard derivations were lower than 10%.
authors.affiliation: Beijing Center for Disease Prevention and Control, Beijing 100013, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Shao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Yongning
authors.initials: Y
authors.lastname: Wu
authors.forename: Guohua
authors.initials: G
authors.lastname: Wu
authors.forename: Ying
authors.initials: Y
authors.lastname: Xue
mesh_terms: D020106:Acrylamide / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods; D005506:Food Contamination / Q000032:analysis*; D006358:Hot Temperature; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D020106:Acrylamide