title: A phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive rats.
abstract: D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.
authors.affiliation: Three B Co., Inc., Nanporo, Japan.
authors.forename: Shin-Ya
authors.initials: SY
authors.lastname: Hagiwara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Shen
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kaihou
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tomiyama
authors.forename: Michio
authors.initials: M
authors.lastname: Yazawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tamai
authors.forename: Yoosu
authors.initials: Y
authors.lastname: Sin
authors.forename: Akio
authors.initials: A
authors.lastname: Kazusaka
authors.forename: Minoru
authors.initials: M
authors.lastname: Terazawa
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D008353:Mannitol / Q000494:pharmacology*; D020076:Pleurotus / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D008353:Mannitol