Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen.
Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4(+):CD8(+) T cell ratio and induction of CD8(+) T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8(+)(ACT2(+) BoCD8(+)) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8(+) T cells (CD8(+)CD26(+)) and well-established human CD4(+)CD25(+) T regulatory (Tr) cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.
Chang
Byoung Sun
BS
Animal Health Research, LG Life Sciences Ltd., Daejeon, Korea.
Bohach
Gregory A
GA
Lee
Sang Un
SU
Davis
William C
WC
Fox
Lawrence K
LK
Ferens
Witold A
WA
Seo
Keun Seok
KS
Koo
Hye Cheong
HC
Kwon
Nam Hoon
NH
Park
Yong Ho
YH
D000818:Animals; D002417:Cattle; D049109:Cell Proliferation; D005260:Female; D008213:Lymphocyte Activation / Q000276:immunology; D008414:Mastitis, Bovine / Q000276:immunology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology / Q000662:veterinary*; D013210:Staphylococcus / Q000276:immunology*; D018089:Superantigens; D013601:T-Lymphocytes / Q000276:immunology*
D018089:Superantigens