title: Preoperative fibrin monomer measurement allows risk stratification for high intraoperative blood loss in elective surgery.
abstract: We recently demonstrated that patients with increased blood loss due to intraoperative coagulopathy show a persistent pre-, intra- and postoperative increase in fibrin monomer concentration. We thus tested the hypothesis that preoperative fibrin monomer concentrations can be used as a risk indicator for intraoperative blood loss in a study designed for diagnostic test evaluation in 168 patients admitted to the surgical service of our hospital. Intraoperative blood loss increased with preoperative fibrin monomer concentration (median blood loss of 50, 100, 200 and 400 ml in preoperative fibrin monomer quartile groups 1 to 4, p<0.001, ANOVA on ranks; interquartile comparisons p < 0.05 (4/6), Mann Whitney Rank Sum test). In contrast, intraoperative blood loss was unrelated to preoperative values of prothrombin time, activated partial thromboplastin time and platelet count. By multivariate (logistic regression) analysis, only fibrin monomer remained a significant predictor of intraoperative blood loss > 500 ml when age, gender, BMI, fibrin monomer and the different types of surgical procedures (tumor surgery, vascular surgery, cholecystectomy, gastric banding, varicous vein surgery and hernia repair) were included as independent variables. Most importantly, accuracy evaluation showed that preoperative fibrin monomer concentration < 3 microg/l excluded intraoperative blood loss > 500 ml with 92% sensitivity and 95% negative predictive value. These results support our hypothesis that preoperative fibrin monomer concentrations are related to intraoperative blood loss in elective surgery. Fibrin monomer should be further investigated for it's potential to serve as a routine tool for preoperative risk stratification of intraoperative bleeding.
authors.affiliation: Institute for Clinical Chemistry and Haematology, Kantonsspital, 9007 St. Gallen, Switzerland. wolfgang.korte@ikch.ch
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Korte
authors.forename: Konrad
authors.initials: K
authors.lastname: Gabi
authors.forename: Mirjam
authors.initials: M
authors.lastname: Rohner
authors.forename: Anita
authors.initials: A
authors.lastname: Gähler
authors.forename: Christine
authors.initials: C
authors.lastname: Szadkowski
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Schnider
authors.forename: Jochen
authors.initials: J
authors.lastname: Lange
authors.forename: Walter
authors.initials: W
authors.lastname: Riesen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016063:Blood Loss, Surgical / Q000517:prevention & control; D001803:Blood Transfusion; D017558:Elective Surgical Procedures / Q000009:adverse effects*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000096:biosynthesis*; D006470:Hemorrhage / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D015203:Reproducibility of Results; D012306:Risk; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer