[Clinical features and treatment of Fisher syndrome].
To clarify the clinical features of patients with Fisher syndrome, we reviewed detailed clinical profiles and laboratory findings in 267 cases. The men:women ratio was about 3:2, median age at onset 42 years, and the two peaks were 30-39 and 50-59. Sixty two percent of the patients had an antecedent illness with upper respiratory infectious symptoms. As initial symptoms, 63% had diplopia, 33% ataxic gait, and 17% dysesthesia of the upper and/or lower limbs. Besides ophthalmoplegia, ataxia, and areflexia, blepharoptosis (42%), internal ophthalmoplegia (35%), facial palsy (25%), and bulbar palsy (16%) were present. Limb weakness was significant in 25% and sensory impairment in 52%. CSF albuminocytological dissociation was present in 80% after the second week. Most patients were given intravenous immunoglobulin (59%). None died, and almost all had a monophasic remitting course and a generally good outcome.
Ito
Masafumi
M
Department of Neurology, Dokkyo University School of Medicine.
Odaka
Masaaki
M
Koga
Michiaki
M
Hirata
Koichi
K
Yuki
Nobuhiro
N
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000503:physiopathology / Q000628:therapy