title: Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury.
abstract: OBJECTIVE
  The authors tested the hypothesis that the dopamine D2 receptor T allele (formerly described as the A1 allele) would be associated with poorer performance on memory and attention tasks following mild traumatic brain injury.
  
  
  METHODS
  Thirty-nine patients with mild traumatic brain injury and 27 comparison subjects were genotyped. All subjects completed memory and attention tests, including the California Verbal Learning Test recognition task and the Continuous Performance Test.
  
  
  RESULTS
  In both groups the T allele was associated with poorer performance on the California Verbal Learning Test recognition task. There was also a significant diagnosis-by-allele interaction on measures of response latency (Continuous Performance Test): the subjects with mild traumatic brain injury and the T allele had the worst performance.
  
  
  CONCLUSIONS
  Genetic polymorphisms modulating central dopaminergic tone can affect cognitive outcome following mild traumatic brain injury.
authors.affiliation: Section of Neuropsychiatry, Department of Psychiatry, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756. thomas.w.mcallister@dartmouth.edu.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: McAllister
authors.forename: C Harker
authors.initials: CH
authors.lastname: Rhodes
authors.forename: Laura A
authors.initials: LA
authors.lastname: Flashman
authors.forename: Brenna C
authors.initials: BC
authors.lastname: McDonald
authors.forename: Dorothy
authors.initials: D
authors.lastname: Belloni
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Saykin
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011930:Reaction Time / Q000235:genetics* / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000502:physiology
chemical_list: D017448:Receptors, Dopamine D2