title: Evaluation of the inhibitory activities of the extracts of Indonesian traditional medicinal plants against Plasmodium falciparum and Babesia gibsoni.
abstract: Twenty-four kinds of water extracts derived from 22 plants that are traditionally used for the treatment of malaria on Java Island, Indonesia, were screened for their antibabesial and antimalarial activities. Among the extracts, 8 extracts displayed strong antimalarial activity, with an inhibition range from 89.6 to 100%, and 15 showed strong antibabesial activity, with an inhibition range from 84.2 to 98.1%. The extracts of Achillea millefolium, Baeckea frutenscens, Brucea javanica, Curcuma xanthorrhiza, Strychnos lucida and Swietenia macrophylla showed both strong antibabesial and antimalarial activities. The antimalarial activities paralleled the antibabesial activities, but the converse was not true.
authors.affiliation: Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
authors.forename: Tri
authors.initials: T
authors.lastname: Murnigsih
authors.lastname: Subeki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuura
authors.forename: Kosaku
authors.initials: K
authors.lastname: Takahashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Maede
authors.forename: Ken
authors.initials: K
authors.lastname: Katakura
authors.forename: Mamoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Sumiko
authors.initials: S
authors.lastname: Kobayashi
authors.lastname: Chairul
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshihara
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000633:toxicity*; D001403:Babesia / Q000187:drug effects*; D007214:Indonesia; D020128:Inhibitory Concentration 50; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000302:isolation & purification / Q000633:toxicity; D010946:Plants, Medicinal / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts