title: Measured microdosimetric spectra and therapeutic potential of boron neutron capture enhancement of 252Cf brachytherapy.
abstract: Californium-252 is a neutron-emitting radioisotope used as a brachytherapy source for radioresistant tumors. Presented here are microdosimetric spectra measured as a function of simulated site diameter and distance from applicator tube 252Cf sources. These spectra were measured using miniature tissue-equivalent proportional counters (TEPCs). An investigation of the clinical potential of boron neutron capture (BNC) enhancement of 252Cf brachytherapy is also provided. The absorbed dose from the BNC reaction was measured using a boron-loaded miniature TEPC. Measured neutron, photon and BNC absorbed dose components are provided as a function of distance from the source. In general, the absorbed dose results show good agreement with results from other measurement techniques. A concomitant boost to 252Cf brachytherapy may be provided through the use of the BNC reaction. The potential magnitude of this BNC enhancement increases with increasing distance from the source and is capable of providing a therapeutic gain greater than 30% at a distance of 5 cm from the source, assuming currently achievable boron concentrations.
authors.affiliation: Gershenson Radiation Oncology Center, Karmanos Cancer Institute, Harper University Hospital and Wayne State University, Detroit, MI 48201, USA. burmeist@kci.wayne.edu
authors.forename: J
authors.initials: J
authors.lastname: Burmeister
authors.forename: C
authors.initials: C
authors.lastname: Kota
authors.forename: R L
authors.initials: RL
authors.lastname: Maughan
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001918:Brachytherapy / Q000379:methods*; D002142:Californium / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D002142:Californium