Characterization of inclusion complexation between fenoxaprop-p-ethyl and cyclodextrin.
Cyclodextrins (CDs) derived from natural starches are capable of forming inclusion complexes with a variety of organic compounds. This work evaluated the complexation role of CDs toward fenoxaprop-p-ethyl (FE) in an attempt to assess their potential as new formulation additives for more efficient FE delivery and better environmental approaches. beta-CD and its two derivatives, randomly methylated beta-CD (RAMEB) and 2-hydroxypropyl beta-CD (HP-beta-CD), were tested. The solubility of FE was enhanced in the presence of the CDs due to the formation of inclusion complexes, with RAMEB being >6 times more effective than the other two. The complexation was confirmed by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD), where the FE melting peaks in DSC, the FTIR bands, and the XRD peaks were generally weakened. Within the tested time up to 60 min, the dissolution of the FE-CD complexes resulted in higher FE concentrations than did that of FE by itself. The dissolution of the FE-RAMEB complex was much faster than other complexes and FE alone. These results indicate that RAMEB was a better inclusion complexation agent for FE in terms of both solubility enhancement and dissolution rate. RAMEB may thus be used to improve FE delivery and to mobilize FE in soil for bioremediation.
Zhang
Anping
A
Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China.
Liu
Weiping
W
Wang
Lumei
L
Wen
Yuezhong
Y
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005503:Food Additives / Q000737:chemistry*; D005506:Food Contamination; D006540:Herbicides / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D005503:Food Additives; D006540:Herbicides; D010080:Oxazoles; D011422:Propionates; D047392:beta-Cyclodextrins; C416661:fenoxaprop ethyl; C031215:betadex