Assessment of the efficacy of total lymphocyte counts as predictors of AIDS defining infections in HIV-1 infected people.
BACKGROUND
The CD4 count is a dominant prognostic and predictive factor in HIV infection. This study assessed the utility of the total lymphocyte count (TLC) in place of the CD4 count to predict the development of AIDS defining opportunistic infections (ADOI).


METHODS
The Chelsea and Westminster cohort was used to identify those people with a first episode of an ADOI. Corresponding CD4 and TLCs were recorded before diagnosis or at the time of first prescribing prophylaxis; patients without an AIDS defining opportunistic infection were defined as being at "risk" and receiver operating characteristic (ROC) curves were used to display the results of sensitivity and the false positive error rate of total lymphocyte and CD4 count groups.


RESULTS
A significant linear correlation was seen between the log(10) CD4 count and log(10) TLC (Pearson's correlation coefficient = 0.70, p<0.001). The finer cut off value for TLC where false positive error rate is minimum and sensitivity maximum was 1500-2000 cells/mm(3). Patients with TLC 1000-1500 cells/mm(3) were estimated to be at 40% increased risk of developing an ADOI. The cut off value for CD4 counts measured 200 cells/mm(3) above which the risk developing an ADOI decreased. Patients with a CD4 count of 150-200 cells/mm(3) were at a 34% increased risk of developing an ADOI. The area under the ROC curve for TLC was 10% lower than that for CD4 count.


CONCLUSIONS
The TLC is minimally less reliable than the CD4 count as a predictor of ADOIs. In the absence of expensive equipment for CD4 measurement, the TLC is a useful test.
Stebbing
J
J
St Stephen's Centre, Chelsea and Westminster Hospital, London, UK. j.stebbing@imperial.ac.uk
Sawleshwarkar
S
S
Michailidis
C
C
Jones
R
R
Bower
M
M
Mandalia
S
S
Nelson
M
M
Gazzard
B
B
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D018655:Lymphocyte Count / Q000379:methods; D011379:Prognosis; D012680:Sensitivity and Specificity