title: Chip-based microelectrodes for detection of single-nucleotide mismatch.
abstract: Microelectrode arrays having eight 10-microm-diameter gold microelectrodes arranged on a gold-covered Si chip were designed and characterized. The chips prove useful for the detection of single-nucleotide mismatches in unlabeled and prehybridized DNA by electrochemical impedance spectroscopy.
authors.affiliation: Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Li
authors.forename: Yinglin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Todd C
authors.initials: TC
authors.lastname: Sutherland
authors.forename: Brian
authors.initials: B
authors.lastname: Baker
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Lee
authors.forename: Heinz-Bernhard
authors.initials: HB
authors.lastname: Kraatz
mesh_terms: D020137:Base Pair Mismatch / Q000235:genetics*; D004247:DNA / Q000032:analysis* / Q000235:genetics; D004563:Electrochemistry; D008839:Microelectrodes; D009711:Nucleotides / Q000032:analysis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*
chemical_list: D009711:Nucleotides; D004247:DNA