Effect of cobalt on the liver glycogen content in the streptozotocin-induced diabetic rats.
Cobalt decreases blood glucose in diabetic rats but the mechanisms involved are unclear. To determine the contribution of glycogen metabolism to glycemia-lowering effect, glycogen contents of liver and muscle in the streptozotocin-induced diabetic rats were determined. The liver glycogen was depleted in diabetic rats. But when cobalt was administered to the rats, the glycogen returned to the level of healthy rats, concomitantly with the decrease in blood glucose. The cobalt treatment had no effect on the muscle glycogen in the diabetic rats. The tissue-specific responses of glycogen metabolism suggest the involvement of suppressed glucagon signaling due to cobalt treatment.
Nomura
Yasutomo
Y
Department of Environmental Life Science, Graduate School of Medical Science, Yamagata University, Yonezawa, Yamagata, 992-8510, Japan. ynomura@yz.yamagata-u.ac.jp
Okamoto
Shin-Ichiro
S
Sakamoto
Mitsuru
M
Feng
Zhonggang
Z
Nakamura
Takao
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003035:Cobalt / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008112:Liver Glycogen; D003035:Cobalt; D006003:Glycogen