Nonsteroidal antiinflammatory drugs: a review.
The increasing use of nonsteroidal antiinflammatory drugs (NSAIDs) in small animals has resulted in the development of new and innovative additions to this class of drugs. Examples of NSAIDs now available for use in small animals include aspirin, etodolac, carprofen, ketoprofen, meloxicam, deracoxib, and tepoxalin. The purposes of this article are to review the pathophysiology of prostaglandin synthesis and inhibition, the mechanisms of action, pharmacokinetics, pharmacological effects, and potential adverse reactions of aspirin and the newly released NSAIDs.
Curry
Stephen L
SL
Department of Veterinary Medicine and Surgery and the Comparative Orthopaedic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA.
Cogar
Steven M
SM
Cook
James L
JL
D000820:Animal Diseases / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D002227:Carbazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D017308:Etodolac / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D007660:Ketoprofen / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D000077239:Meloxicam; D011720:Pyrazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D013449:Sulfonamides / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D013843:Thiazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D013844:Thiazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome; D000096926:Benzenesulfonamides
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D002227:Carbazoles; D017308:Etodolac; D007660:Ketoprofen; D000077239:Meloxicam; D011720:Pyrazoles; D013449:Sulfonamides; D013843:Thiazines; D013844:Thiazoles; C007005:carprofen; C073135:tepoxalin; C471996:deracoxib; D000096926:Benzenesulfonamides