[Correction of facial lipoatrophy with a biodegradable material in HIV-infected patients].
BACKGROUND
Facial lipoatrophy in HIV-infected patients under tri-therapy occurs frequently and alters their quality of life. No systemic treatment is capable of curing this problem.


METHODS
Eighty-one patients were included in an open, prospective, compassionate study. A strict intradermal injection of a biodegradable, polyacrylamide cationic copolymer was administered in several sessions.


RESULTS
In all the patients, the correction of the facial lipoatrophy was considered satisfactory and stable over a period of 6 months using comparative photographic clichés. The thickness of the dermal skin, assessed by sonography, was doubled. No local or systemic side effect was reported.


CONCLUSIONS
Our study shows that is it possible to durably correct the facial lipoatrophy of HIV-infected patients under tri-therapy by using a biodegradable implant.
Carbonnel
E
E
Service de Dermatologie, Hôpital Edouard Herriot, Lyon.
Claudy
A
A
D000180:Acrylic Resins / Q000008:administration & dosage* / Q000627:therapeutic use*; D000328:Adult; D001672:Biocompatible Materials; D005145:Face / Q000473:pathology; D015658:HIV Infections / Q000150:complications; D039682:HIV-Associated Lipodystrophy Syndrome / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome; D000099166:Polyacrylamides
D000180:Acrylic Resins; D001672:Biocompatible Materials; D000099166:Polyacrylamides