title: Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant.
abstract: We report the clinical course of a patient who developed a Rhizopus infection of his right lung and pleural cavity, 11 months after receiving a T-cell-depleted, haploidentical donor peripheral blood stem cell transplant. Thoracotomy was performed to remove the pulmonary lesion, but residual disease in the pleural cavity was noted. Treatment with amphotericin B was complicated by the development of severe renal dysfunction, necessitating alternative antifungal therapy. Treatment was initiated with the investigational triazole posaconazole. Despite concurrent treatment with corticosteroids for graft-versus-host disease (GVHD), the patient had a complete response and remains well 4 years later.
authors.affiliation: Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7220, USA. agilman@med.unc.edu
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Gilman
authors.forename: Amy
authors.initials: A
authors.lastname: Serrano
authors.forename: John
authors.initials: J
authors.lastname: Skelley
authors.forename: David
authors.initials: D
authors.lastname: Zwick
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000628:therapy; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014230:Triazoles / Q000627:therapeutic use*; D020096:Zygomycosis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole