[New advances in Sox gene family].
The Sox family of transcription factors are found throughout the animal kingdom. They are characterized by the presence of a HMG domain, involved in the regulation of such diverse developmental processes of early embryogenesis as sex determination,chondrogenesis,haemopoiesis,neural development and lens development. The deletion or mutation of SOX proteins results in developmental defects and congential disease in human. One Sox gene has different effects on the same promoters in the different cells or the different promoters in a cell. Some Sox gene exhibit a remarkable crosstalk and functional redundancy among each other. This paper reviewed the advances related to the Sox gene family in recent years.
Chang
Zhong-jie
ZJ
College of life sciences, Henan Normal University, Xinxiang city,453002, China. zhjch@public.xxptt.ha.cn
Du
Qi-yan
QY
Shao
Hong-wei
HW