title: Conventional and molecular epidemiology of macrolide resistance among new Mycobacterium avium complex isolates recovered from HIV-infected patients.
abstract: We performed a retrospective cohort study of human immunodeficiency virus (HIV)-associated Mycobacterium avium complex (MAC) infection during 1997-2004 to assess for factors associated with initial macrolide resistance. Of 52 HIV-associated sterile-site MAC isolates, 9 (17%) were initially macrolide resistant. Prior MAC treatment and prolonged MAC prophylaxis with macrolides were associated with infection with a macrolide-resistant isolate; 2 (22%) of 9 patients had limited or no prior macrolide exposure. Initial MAC isolates in HIV-infected persons should routinely be tested for macrolide resistance.
authors.affiliation: Denver Public Health, Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80204, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Gardner
authors.forename: William J
authors.initials: WJ
authors.lastname: Burman
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: DeGroote
authors.forename: Ginger
authors.initials: G
authors.lastname: Hildred
authors.forename: Norman R
authors.initials: NR
authors.lastname: Pace
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015331:Cohort Studies; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology*; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides