Abnormality in the cerebellar folial pattern of C57BL/6J mice.
The characteristic folial pattern of the mouse cerebellum is formed during postnatal development. We observed this process in C57BL/6J (B6) mice in detail, and found an abnormal folial pattern in a specific region (lobules VIII and IX of the vermis) in a substantial number of B6 mice. The frequency of this abnormality increased during postnatal development and reached 55% in the adult. Thus, the present study showed an abnormality in the cerebellar folial pattern of B6 mice, a mouse widely used in knockout studies, and called for caution in the phenotypic analysis of knockout mice of the B6 genetic background.
Tanaka
Masahiko
M
Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan. mtanaka@fujita-hu.ac.jp
Marunouchi
Tohru
T
D000818:Animals; D000831:Animals, Newborn; D015220:Calcium Channels / Q000378:metabolism; D002531:Cerebellum / Q000002:abnormalities* / Q000033:anatomy & histology* / Q000254:growth & development* / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051379:Mice; D008810:Mice, Inbred C57BL / Q000254:growth & development*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear