title: Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without hepatic dysfunction.
abstract: The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (+/- SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 +/- 0.24 and 22.5 +/- 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-beta. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-alpha, and interferon-gamma than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Pyung-Dong 108, Jongro-Ku, Seoul 110-746, Republic of Korea.
authors.forename: Joon-Sup
authors.initials: JS
authors.lastname: Yeom
authors.forename: Se-Ho
authors.initials: SH
authors.lastname: Park
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Hae-Kyung
authors.initials: HK
authors.lastname: Park
authors.forename: So-Youn
authors.initials: SY
authors.lastname: Woo
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Ha
authors.forename: Bo-Eun
authors.initials: BE
authors.lastname: Lee
authors.forename: Kwon
authors.initials: K
authors.lastname: Yoo
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Kwang-Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Sunhil
authors.initials: S
authors.lastname: Kim
authors.forename: Young-A
authors.initials: YA
authors.lastname: Kim
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Ahn
authors.forename: Sejoong
authors.initials: S
authors.lastname: Oh
authors.forename: Hyung-Joo
authors.initials: HJ
authors.lastname: Park
authors.forename: Gi-Sik
authors.initials: GS
authors.lastname: Min
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Seoh
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Park
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007723:Korea; D008109:Liver Diseases, Parasitic / Q000097:blood*; D016780:Malaria, Vivax / Q000097:blood* / Q000150:complications; D008297:Male; D008889:Military Personnel; D012189:Retrospective Studies
chemical_list: D016207:Cytokines