title: Therapeutic tolerance--does it exist?
abstract: I will try to approach this somewhat provocative title with a consideration that therapeutic tolerance is already in the clinic, whether induced by deliberate and repeatable therapeutic measures, or occurring as an accidental bonus. I am going to discuss approaches to try and extend the scope of tolerance and introduce the concept of near or prope tolerance, and finally a few comments on the likely directions of future research.
authors.forename: Sir Roy Y
authors.initials: SR
authors.lastname: Calne
mesh_terms: D000074323:Alemtuzumab; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016377:Organ Transplantation; D014181:Transplantation Immunology
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D007166:Immunosuppressive Agents; D000074323:Alemtuzumab