Chronic beta-adrenoceptor stimulation and cardiac hypertrophy with no induction of circulating renin.
The hemodynamic and cardiac effects of isoproterenol were examined in rats submitted to chronic salt loading (1% NaCl as drinking water) to prevent activation of the systemic renin-angiotensin system. Isoproterenol treatment for 1 week resulted in 36% and 44% (P<0.05) increase in left ventricle mass in both control and chronic salt loading rats and induction of cardiac angiotensin-converting enzyme activity and expression (P<0.05) with no changes in serum angiotensin-converting enzyme. Plasma renin activity decreased significantly with chronic salt loading and failed to increase by isoproterenol treatment, whereas it increased 2.33 fold (P<0.05) in animals kept on regular chow. Isoproterenol treatment leads to transient increase in heart rate and cardiac output while blood pressure remained unchanged. Altogether, these data provide evidence that isoproterenol induced hypertrophy is associated with cardiac induction of angiotensin-converting enzyme and daily transient hemodynamic overload even in the absence of systemic activation of renin-angiotensin system.
Oliveira
Edilamar M
EM
Laboratory of Biochemistry, School of Physical Education and Sports, University of São Paulo, São Paulo, SP, Brazil.
Krieger
José E
JE
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D002302:Cardiac Output / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D017379:Hypertrophy, Left Ventricular / Q000139:chemically induced / Q000503:physiopathology*; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology; D017673:Sodium Chloride, Dietary; D015854:Up-Regulation
D000318:Adrenergic beta-Agonists; D012333:RNA, Messenger; D017673:Sodium Chloride, Dietary; D009320:Atrial Natriuretic Factor; D007703:Peptidyl-Dipeptidase A; D012083:Renin; D007545:Isoproterenol