title: Distal femoral tumours treated by resection and custom mega-prosthetic replacement.
abstract: We have analysed the results of 246 cases of distal femoral tumours treated by resection and prosthetic replacement between 1988 and 2002. Patient ages ranged from 6-67 years averaging 24 years; 133 were males. The most common tumour was osteosarcoma (67% of patients). The follow-up ranged from 2 to 14 years. Stage II tumours were seen in 72% of patients. The technique of sleeve resection of the quadriceps musculature was followed to achieve local clearance of the tumour. The prosthesis used was a rotating hinge custom mega-prosthesis manufactured locally. The functional result achieved was excellent or good in 87%; 86% of the patients had no evidence of disease, and 13% had died. The 10-year patient survival was 76.9%. Periprosthetic fracture and infection were the most common complications.
authors.affiliation: Department of Orthopaedics and Traumatology, Madras Medical College and Research Institute, Government General Hospital, Chennai, 600 003, India. drmayil@bonetumour.org
authors.forename: Mayil Vahanan
authors.initials: MV
authors.lastname: Natarajan
authors.forename: A
authors.initials: A
authors.lastname: Sivaseelam
authors.forename: S
authors.initials: S
authors.lastname: Ayyappan
authors.forename: Jagadesh Chandra
authors.initials: JC
authors.lastname: Bose
authors.forename: M
authors.initials: M
authors.lastname: Sampath Kumar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011859:Radiography; D016896:Treatment Outcome