Primary immune deficiencies presenting in adults: seven years of experience from Iran.
Primary immunodeficiencies (PIDs) are not solely diseases of childhood. We describe the clinical presentation and outcome for 55 adult patients with previously unrecognized PIDs. This series provides unique data regarding PIDs presenting in adulthood, and serves as a timely reminder that physicians must consider the diagnosis of PIDs in their adult patients. Using the experience gained from these patients, we outline key "warning signs" suggestive of an underlying PID. Only through increased physician awareness will patients with PIDs receive timely diagnosis and optimal management.
Mansouri
Davood
D
National Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences, Darabad, Tehran, Iran. dmansouree@yahoo.com
Adimi
Parisa
P
Mirsaedi
Mehdi
M
Mansouri
Nahal
N
Tabarsi
Payam
P
Amiri
Majid
M
Jamaati
Hamid R
HR
Motavasseli
Masoud
M
Baghaii
Noushin
N
Cheraghvandi
Ali
A
Rouhi
Reza
R
Roozbahany
Navid A
NA
Zahirifard
Soheila
S
Mohammadi
Forouzan
F
Masjedi
Mohammad R
MR
Velayati
Ali A
AA
Casanova
Jean L
JL
Speert
David P
DP
Elwood
R Kevin
RK
Schellenberg
Robert
R
Turvey
Stuart E
SE
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D000368:Aged; D001260:Ataxia Telangiectasia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology*; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency; D050718:Complement C1 Inhibitor Protein; D003937:Diagnosis, Differential; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics; D007136:Immunoglobulins / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics; D007492:Iran; D007589:Job Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D012189:Retrospective Studies; D015843:Serpins / Q000172:deficiency; D014923:Wiskott-Aldrich Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology
D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; D007136:Immunoglobulins; C469952:SERPING1 protein, human; D015843:Serpins