title: The value of prior information for detection of QTL affecting longitudinal traits: an example using Von Bertalanffy growth function.
abstract: A Bayesian procedure is presented for detecting quantitative trait loci (QTL) affecting longitudinal traits. The statistical model assumes a QTL affecting the prior distribution of the parameters of a given production function, under a hierarchical Bayesian scheme. Marginal posterior distributions for the effects associated with the QTL are calculated using Markov chain Monte Carlo methods. Furthermore, the Bayesian analysis allows the use of some available relevant information that can improve the detection of the QTL substantially. To illustrate the procedure, an example of QTL detection using the Von Bertalanffy growth function is presented with a F2 pig population bred from Iberian boars and Landrace sows. Animals of the F2 population were genotyped for seven markers in chromosome 2 (SSC2). Two prior distributions for the mean effect of the parameters related with birth and adult weight were compared. On the one hand, vague prior distributions were used, and, on the other, there were assumed univariate Gaussian distributions that ensure biologically meaningful adult and birth weights on the posterior growth curves. Results from the second prior distribution supported the presence of QTL, by showing that individuals with both alleles of Iberian origin had lower rates of maturation. On the contrary, when vague priors were used, the procedure was not able to detect QTL.
authors.affiliation: Area de Producció Animal, Centre UdL-IRTA, Lleida, Spain. luis.varona@irta.es
authors.forename: L
authors.initials: L
authors.lastname: Varona
authors.forename: L
authors.initials: L
authors.lastname: Gómez-Raya
authors.forename: W M
authors.initials: WM
authors.lastname: Rauw
authors.forename: C
authors.initials: C
authors.lastname: Ovilo
authors.forename: A
authors.initials: A
authors.lastname: Clop
authors.forename: J L
authors.initials: JL
authors.lastname: Noguera
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D001835:Body Weight / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D008390:Markov Chains; D008957:Models, Genetic; D015233:Models, Statistical; D009010:Monte Carlo Method; D040641:Quantitative Trait Loci / Q000235:genetics*; D013552:Swine / Q000235:genetics* / Q000254:growth & development*
chemical_list: D005819:Genetic Markers