Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.
McCooey
Séamus H
SH
Centre for Synthesis and Chemical Biology, Department of Chemistry, Trinity College, University of Dublin, Dublin 2, Ireland.
Connon
Stephen J
SJ
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
D000475:Alkenes; D002930:Cinchona Alkaloids; D008314:Malonates; D009574:Nitro Compounds; D014508:Urea; C030290:malonic acid; D013890:Thiourea