title: Leukoplakia of oral mucosa: pathogenesis and possible correction with phytoadaptogen.
abstract: Leukoplakia of the oral mucosa is characterized by impairment of the epithelial differentiation program. The use of complex phytoadaptogen in the treatment of patients with leukoplakia normalized expression of Fas-APO-1 antigen and keratin 17; increased expression of CD54 attested to activation of immune effectors. The clinical effect manifested in involution or shrinkage and loosening of the pathological focus and complete epithelialization of erosive surfaces. The phytopreparation exhibited adaptogenic effects normalizing the immune and IFN status and improving the state of adaptation systems in the body.
authors.affiliation: N N Blokhin Russian Center of Cancer Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: O A
authors.initials: OA
authors.lastname: Bocharova
authors.forename: M M
authors.initials: MM
authors.lastname: Pozharitskaya
authors.forename: T L
authors.initials: TL
authors.lastname: Chekalina
authors.forename: M A
authors.initials: MA
authors.lastname: Lyzhenkova
authors.forename: R V
authors.initials: RV
authors.lastname: Karpova
authors.forename: M V
authors.initials: MV
authors.lastname: Mezentseva
authors.forename: F I
authors.initials: FI
authors.lastname: Ershov
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000502:physiology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007971:Leukoplakia / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D015815:Cell Adhesion Molecules; C401831:PM 40; D010936:Plant Extracts