title: Scedosporium apiospermum brain abscess treated with surgery and voriconazole. Case report.
abstract: Scedosporium apiospermum is a fungus found in the soil and in contaminated water. Common cutaneous manifestations include Madura foot, a painless swelling on the sole of the foot. Invasive infection is usually associated with immunosuppression. The authors present a 16-month-old immunocompetent boy who had a near-drowning event. Following this, he was severely disabled with spastic quadriparesis. Early computerized tomography scans revealed diffuse hypoxic injury. Magnetic resonance images obtained 3 months after the initial event demonstrated multiple ring-enhancing lesions in the brain. Aspiration of the lesion was performed. Scedosporium apiospermum, the asexual form of Pseudallescheria boydii, was cultured. Conventional antifungal agents were commenced, with minimal effect. The child was subsequently treated with a new antifungal agent, voriconazole, a broad-spectrum triazole antifungal agent with good penetration into the cerebrospinal fluid. The patient improved, with a good radiological outcome and a moderate clinical outcome. The authors review the use of voriconazole for central nervous system infections and review the literature on S. apiospermum associated with near drowning.
authors.affiliation: Department of Neurosurgery, Kings College Hospital, Denmark Hill, London, United Kingdom. aabric@yahoo.com
authors.forename: Aabir
authors.initials: A
authors.lastname: Chakraborty
authors.forename: Maria Rella
authors.initials: MR
authors.lastname: Workman
authors.forename: Peter R
authors.initials: PR
authors.lastname: Bullock
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D004322:Drainage; D006801:Humans; D007121:Immunocompetence; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008271:Mycetoma / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D015701:Near Drowning / Q000150:complications; D019635:Neurosurgical Procedures / Q000379:methods; D011743:Pyrimidines / Q000627:therapeutic use*; D011782:Quadriplegia / Q000209:etiology / Q000628:therapy; D021681:Scedosporium / Q000302:isolation & purification*; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole