title: Semiconductor laser insert with uniform illumination for use in photodynamic therapy.
abstract: A low-cost semiconductor red laser light delivery system for esophagus cancer treatment is presented. The system is small enough for insertion into the patient's body. Scattering elements with nanoscale particles are used to achieve uniform illumination. The scattering element optimization calculations, with Mie theory, provide scattering and absorption efficiency factors for scattering particles composed of various materials. The possibility of using randomly deformed spheres and composite particles instead of perfect spheres is analyzed using an extension to Mie theory. The measured radiation pattern from a prototype light delivery system fabricated using these design criteria shows reasonable agreement with the theoretically predicted pattern.
authors.affiliation: Department of Mechanical Engineering, Southern Methodist University, Dallas, Texas 75275, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Charamisinau
authors.forename: Gemunu
authors.initials: G
authors.lastname: Happawana
authors.forename: Gary
authors.initials: G
authors.lastname: Evans
authors.forename: Arye
authors.initials: A
authors.lastname: Rosen
authors.forename: Richard A
authors.initials: RA
authors.lastname: Hsi
authors.forename: David
authors.initials: D
authors.lastname: Bour
mesh_terms: D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005240:Feasibility Studies; D006801:Humans; D053685:Laser Therapy; D043942:Nanotubes; D010778:Photochemotherapy / Q000295:instrumentation* / Q000379:methods; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012542:Scattering, Radiation; D012666:Semiconductors; D014159:Transducers
chemical_list: D017319:Photosensitizing Agents