title: Adrenaline during mental stress in relation to fitness, metabolic risk factors and cardiovascular responses in young men.
abstract: We studied plasma adrenaline (A) in relation to physical fitness, metabolic cardiovascular risk factors and cardiovascular responses. Men (age 21-24 years) with high and normal (both n=19) screening blood pressure (BP) were studied cross-sectionally. We measured peak oxygen uptake (VO2peak) (treadmill exercise), and plasma catecholamines, heart rate (HR), finger systolic (SBP) and diastolic (DBP) BP, and insulin-adjusted glucose disposal rate (GDR/I) during a hyperinsulinaemic glucose clamp (rest) and mental arithmetic stress test (MST). By multiple regression, A at rest (Arest) (beta=0.37, p<0.05) and during MST (Amst) (beta=0.40, p<0.01) were associated with high screening BP. In the respective models, Arest was negatively related to body mass index (BMI) (beta=-0.56, p<0.001) and Amst positively to VO2peak (beta=0.54, p<0.001). BP and HR responses correlated positively with VO2peak, but were determined by Amst in multiple regression models. Independently of BMI and VO2peak, serum high-density lipoprotein cholesterol was positively related to A levels, whereas GDR/I was independently related only to VO2peak. Increased adrenaline secretion may be related to high BP, but may at the same time be associated with a beneficial metabolic profile.
authors.affiliation: Department of Cardiology, Ullevaal University Hospital, Oslo, Norway. h.m.reims@medisin.uio.no
authors.forename: Henrik M
authors.initials: HM
authors.lastname: Reims
authors.forename: Knut
authors.initials: K
authors.lastname: Sevre
authors.forename: Eigil
authors.initials: E
authors.lastname: Fossum
authors.forename: Harald
authors.initials: H
authors.lastname: Mellem
authors.forename: Ivar K
authors.initials: IK
authors.lastname: Eide
authors.forename: Sverre E
authors.initials: SE
authors.lastname: Kjeldsen
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D003430:Cross-Sectional Studies; D004837:Epinephrine / Q000097:blood*; D005947:Glucose / Q000378:metabolism; D015309:Glucose Clamp Technique; D006339:Heart Rate; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D010809:Physical Fitness / Q000502:physiology*; D011897:Random Allocation; D012307:Risk Factors; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology
chemical_list: D005947:Glucose; D004837:Epinephrine