Synthesis and characterization of novel polyanhydrides with tailored erosion mechanisms.
We have designed a new synthesis route to create polyanhydrides based on monomers that contain hydrophilic entities within highly hydrophobic backbones. The method results in polyanhydrides that can be easily processed into drug-containing tablets. The synthesis, characterization, and erosion studies of polyanhydride copolymers based on 1,6-bis(p-carboxyphenoxy)hexane (CPH), which is highly hydrophobic, and 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG), which has hydrophilic oligomeric ethylene glycol segments in the monomer unit, was performed using a combination of molecular spectroscopy, thermal analysis, gravimetry, and scanning electron microscopy. The studies demonstrate that by increasing the CPH content in the CPTEG:CPH copolymers, the erosion of the system can be tailored from bulk-eroding to surface-eroding mechanism. These systems have promise as protein carriers.
Torres
María P
MP
Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, USA.
Vogel
Brandon M
BM
Narasimhan
Balaji
B
Mallapragada
Surya K
SK
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D001673:Biodegradation, Environmental; D004337:Drug Carriers; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D049388:Polyanhydrides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013499:Surface Properties; D013816:Thermodynamics
D001672:Biocompatible Materials; D004337:Drug Carriers; D049388:Polyanhydrides