title: Results of second-look resection after primary resection of T1 tumour of the urinary bladder.
abstract: OBJECTIVE
  To study residual tumours at second-look resection in patients resected 4-8 weeks earlier for T1 tumours of the urinary bladder.
  
  
  METHODS
  All patients randomized in the ongoing Nordic T1G2-G3 Bladder Sparing Study with monitored data available were included in the study. Data on residual tumours at second-look resection were compared to basic patient and tumour characteristics.
  
  
  RESULTS
  There were 72 patients (56%) without and 57 with residual exophytic tumours. In the former group, 20 patients (28%) had carcinoma in situ, compared to 19 (33%) in the latter group. Potentially dangerous tumours (either carcinoma in situ, T1 or Ta grade 3) were observed in 55 patients (43%). Multiple tumours at primary resection were more prone to residual tumour at second-look resection than single tumours. No other tumour or patient characteristics could predict the occurrence of a residual tumour.
  
  
  CONCLUSIONS
  Residual tumours are frequently observed at second-look resection 4-8 weeks after primary resection of T1 tumours. The majority of residual tumours detected at this stage are potentially dangerous; therefore, early second-look resection followed by intravesical instillation therapy is mandatory in patients with T1 tumours of the urinary bladder.
authors.affiliation: Department of Urology, University Hospital, Linköping, Sweden. Staffan.Jahnson@lio.se
authors.forename: Staffan
authors.initials: S
authors.lastname: Jahnson
authors.forename: Fredrik
authors.initials: F
authors.lastname: Wiklund
authors.forename: Milos
authors.initials: M
authors.lastname: Duchek
authors.forename: Oddvar
authors.initials: O
authors.lastname: Mestad
authors.forename: Erkki
authors.initials: E
authors.lastname: Rintala
authors.forename: Sverker
authors.initials: S
authors.lastname: Hellsten
authors.forename: Per-Uno
authors.initials: PU
authors.lastname: Malmström
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D024162:Second-Look Surgery; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*