title: Effect of competitive marathon cycling on plasma N-terminal pro-brain natriuretic peptide and cardiac troponin T in healthy recreational cyclists.
abstract: For a further depiction of exercise-induced cardiac dysfunction, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T (cTnT) were measured in recreational cyclists (n = 29) during the Otztal Radmarathon 2004. In all subjects, NT-pro-BNP significantly increased from 28 +/- 21 to 278 +/- 152 ng/L immediately after the race (p <0.001), decreased again on the following day, and returned to baseline values 1 week later. The mean percentage increase in NT-pro-BNP was 1,128 +/- 803%. CTnT, negative in all subjects before the race, increased transiently in 13 athletes (45%), with levels ranging from 0.043 to 0.224 mug/L in 8 of them (28%). One day after competition, cTnT had normalized in all athletes. Because of the typical release of kinetics, the deflection of NT-pro-BNP is considered to be the adequate volume regulatory response of a hemodynamically stressed heart to prolonged strenuous exercise. The observed kinetics of cTnT substantiate a release from the free cytoplasmatic pool due to the half-life of cytosolic cTnT. In healthy cyclists, transient increases in NT-pro-BNP and cTnT are more likely to reflect cardiac fatigue than injury.
authors.affiliation: Institute of Sports Medicine & Cardiovascular Medicine, University Clinics of Innsbruck, Innsbruck, Austria. guenther.neumayr@sb-bruneck.it
authors.forename: Guenther
authors.initials: G
authors.lastname: Neumayr
authors.forename: Rudolf
authors.initials: R
authors.lastname: Pfister
authors.forename: Guenther
authors.initials: G
authors.lastname: Mitterbauer
authors.forename: Guenther
authors.initials: G
authors.lastname: Eibl
authors.forename: Helmut
authors.initials: H
authors.lastname: Hoertnagl
mesh_terms: D000328:Adult; D001642:Bicycling / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011237:Predictive Value of Tests; D012016:Reference Values; D012189:Retrospective Studies; D020107:Troponin T / Q000097:blood*; D018754:Ventricular Dysfunction / Q000097:blood / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain