title: Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers.
abstract: Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.
authors.affiliation: Department of Physics, The University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Almut
authors.initials: A
authors.lastname: Mecke
authors.forename: Dong-Kuk
authors.initials: DK
authors.lastname: Lee
authors.forename: Ayyalusamy
authors.initials: A
authors.lastname: Ramamoorthy
authors.forename: Bradford G
authors.initials: BG
authors.lastname: Orr
authors.forename: Mark M Banaszak
authors.initials: MM
authors.lastname: Holl
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000737:chemistry; D050091:Dendrimers; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D000071228:Polyelectrolytes; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D023181:Antimicrobial Cationic Peptides; D050091:Dendrimers; D004134:Dimyristoylphosphatidylcholine; D008051:Lipid Bilayers; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers; C104700:PAMAM Starburst; C093828:pexiganan