Novel imidazolidine-tetrazole organocatalyst for asymmetric conjugate addition of nitroalkanes.
The Michael addition of nitroalkanes to alpha,beta-unsaturated enones catalyzed by a novel chiral imidazolidine-2-yltetrazole organocatalyst has been investigated. The new more soluble organocatalyst decreases reaction times and improves enantioselectivities compared to other catalysts. The Michael addition adducts were obtained with up to 92% ee. [reaction: see text]
Prieto
Auxiliadora
A
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
Halland
Nis
N
Jørgensen
Karl Anker
KA