title: [Subcutaneous leiomyosarcoma metastatic to the eyelid].
abstract: BACKGROUND
  Metastatic eyelid lesions are rare. Most metastatic lesions to the eyelid are carcinomas. Leiomyosarcomas are soft tissue sarcomas arising most commonly in the uterus and gastrointestinal tract, whereas dermal leiomyosarcomas are less frequent. Dermal leiomyosarcomas metastatic to the eyelid have not been reported so far.
  
  
  METHODS
  A 28-year-old female patient presented with a rapidly growing tumor of her right lower eyelid. A subcutaneous leiomyosarcoma of the neck had been excised 21 months before with subsequent radiotherapy. Seven months later metastases to the lung, liver, and left upper arm were detected. The patient received chemotherapy. The eyelid tumor was completely excised. Histologically the lesion consisted of spindle cells arranged in fascicles with perinuclear vacuoles and myofilaments. There was a strong immunoreactivity for smooth muscle actin, and negative staining for cytokeratin and S100.
  
  
  CONCLUSIONS
  Cutaneous and subcutaneous leiomyosarcomas occur at almost any age, but are most common between the 5th and 7th decades. They are more common in men and usually occur at the extremities. The prognosis of cutaneous/subcutaneous leiomyosarcoma correlates with the depth of the tumor. To our knowledge this is the first presentation of a subcutaneous leiomyosarcoma metastatic to the eyelid. Presumably, parenchymatous metastases of this tumor occur before dermal metastases arise.
authors.affiliation: Universitäts-Augenklinik, Heidelberg, Germany. julia.wrede@med.uni-heidelberg.de
authors.forename: J
authors.initials: J
authors.lastname: Wrede
authors.forename: H E
authors.initials: HE
authors.lastname: Völcker
authors.forename: S
authors.initials: S
authors.lastname: Dithmar
mesh_terms: D000328:Adult; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome