title: Copper complexes for fluorescence-based NO detection in aqueous solution.
abstract: Two copper(II) complexes containing dansylated ligands were investigated as turn-on fluorescence-based nitric oxide (NO) sensors. Upon addition of NO (g), the quenched fluorescence of both complexes was restored in both organic and buffered aqueous solutions, which is caused by the formation of a diamagnetic Cu(I) species and protonation of the sulfonamide functionality of the ligands. The NO detection limit of these Cu(II) complexes is 10 nM.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Lim
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard
mesh_terms: D003300:Copper / Q000032:analysis* / Q000737:chemistry; D005453:Fluorescence; D008956:Models, Chemical; D009569:Nitric Oxide / Q000032:analysis*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D009569:Nitric Oxide; D003300:Copper