Ancient haplotypes of the HLA Class II region.
Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the approximately 100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination.
Raymond
Christopher K
CK
University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
Kas
Arnold
A
Paddock
Marcia
M
Qiu
Ruolan
R
Zhou
Yang
Y
Subramanian
Sandhya
S
Chang
Jean
J
Palmieri
Anthony
A
Haugen
Eric
E
Kaul
Rajinder
R
Olson
Maynard V
MV
D000483:Alleles; D000818:Animals; D019143:Evolution, Molecular; D005802:Genes, MHC Class II; D014644:Genetic Variation; D015894:Genome, Human; D006071:Gorilla gorilla / Q000235:genetics / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics / Q000276:immunology; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012641:Selection, Genetic
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains