title: Treatment and prognosis of chondroblastoma.
abstract: Chondroblastoma is an aggressive tumor of bone with the capacity for recurrence and metastasis. We sought to determine the prognostic factors that affect survival and local recurrence with particular emphasis on surgical technique and the anatomic constraints of the open physis. It was hypothesized that an open growth plate would impact the local recurrence rate negatively and be a primary determinant of treatment outcome. We retrospectively reviewed 82 consecutive patients treated at one institution. Intralesional treatment with meticulous curettage and bone graft resulted in local control in the majority of patients. Four local recurrences developed between 5 and 51 months. An open growth plate was not found to correlate with local recurrence. In most cases, the open physis did not considerably impact surgical technique. Although the median age of the patients was 16 years, the majority of patients had a closed or closing physis. Few patients had substantial growth remaining. A physeal-sparing operation was done in six patients, and no local recurrences were observed in this group. The factors that seemed to affect local recurrence included inadequate surgery and biologic aggressiveness of the tumor. Inadequate surgery was likely to be the cause of local recurrence in patients who presented after previous treatment elsewhere. Three patients who developed local recurrence manifested increased biologic aggressiveness of disease. These patients subsequently developed metastatic disease and malignant transformation of disease. All three patients died from their disease. Pelvic tumors tend to be biologically more aggressive and more apt to recur locally and metastasize to distant locations.
  
  
  METHODS
  Therapeutic Study, Level IV (case series). See the Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77230, USA. plin@mdanderson.org
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Lin
authors.forename: Arun
authors.initials: A
authors.lastname: Thenappan
authors.forename: Michael T
authors.initials: MT
authors.lastname: Deavers
authors.forename: Valerae O
authors.initials: VO
authors.lastname: Lewis
authors.forename: Alan W
authors.initials: AW
authors.lastname: Yasko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D002648:Child; D002804:Chondroblastoma / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D015331:Cohort Studies; D018572:Disease-Free Survival; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies