title: Prospective analysis of patients with adenocarcinoma of the gastric cardia and lymph node metastasis in the proximal field of the chest.
abstract: BACKGROUND
  The extent to which adenocarcinoma of the cardia with lymph node metastasis in the upper mediastinum is amenable to cure by radical surgery is open to debate. It remains unclear whether these relatively distant metastases have an effect on long-term survival. The aim of this study was to identify the incidence of such positive nodes and evaluate their prognostic significance.
  
  
  METHODS
  Some 50 patients with adenocarcinoma of the gastric cardia and substantial invasion of the oesophagus (junctional type II), who underwent an extended transthoracic oesophagectomy as part of a prospective randomized trial between 1994 and 2000, were studied.
  
  
  RESULTS
  Eleven patients (22 per cent) had lymph node metastasis in the proximal field of the chest. These patients had more positive nodes overall (P = 0.020) and a shorter median survival (P = 0.009) than those without such metastasis. Multivariate analysis identified positive nodes in the proximal field as an independent predictor of poor survival.
  
  
  CONCLUSIONS
  Lymph node metastasis in the proximal field of the chest is common and is an indicator of poor prognosis in patients with adenocarcinoma of the cardia.
authors.affiliation: Department of Surgery, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. S.M.Lagarde@amc.uva.nl
authors.forename: S M
authors.initials: SM
authors.lastname: Lagarde
authors.forename: H A
authors.initials: HA
authors.lastname: Cense
authors.forename: J B F
authors.initials: JB
authors.lastname: Hulscher
authors.forename: H W
authors.initials: HW
authors.lastname: Tilanus
authors.forename: F J W
authors.initials: FJ
authors.lastname: Ten Kate
authors.forename: H
authors.initials: H
authors.lastname: Obertop
authors.forename: J J B
authors.initials: JJ
authors.lastname: van Lanschot
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery*; D000368:Aged; D002299:Cardia; D016629:Esophagectomy / Q000379:methods; D005260:Female; D006801:Humans; D015994:Incidence; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000401:mortality / Q000556:secondary*; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*; D016019:Survival Analysis