title: INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women.
abstract: The relevance of the insulin gene (INS) variable number tandem repeat (VNTR) polymorphism to indexes of body size and adult obesity is inconclusive. Given the equivocal reports on the association between the VNTR class genotype at the insulin gene locus and indexes of body size and obesity, we assessed these associations in a series of cohort studies based on 7,999 middle-aged men and women. We found no convincing evidence that INS VNTR class genotype was associated with indexes of body size and adult obesity. These data suggest that INS VNTR class is not an important determinant of size and body weight regulation in middle-aged men and women.
authors.affiliation: Department of Public Health & Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, UK. manj.sandhu@srl.cam.ac.uk
authors.forename: Manjinder S
authors.initials: MS
authors.lastname: Sandhu
authors.forename: Barbara
authors.initials: B
authors.lastname: Heude
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Young
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.forename: Jian'an
authors.initials: J
authors.lastname: Luan
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: John
authors.initials: J
authors.lastname: Todd
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
mesh_terms: D000368:Aged; D049628:Body Size / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D007328:Insulin