Omeprazole affects neither electroconvulsive threshold nor anticonvulsant activity of diphenylhydantoin and carbamazepine in mice.
Omeprazole is a commonly prescribed drug for patients with peptic ulcerations. Its main mechanism of action is related to inhibition of H(+)-K(+)-ATP-ase, albeit it may also block carbonic anhydrase. This study evaluates the effects of acute and prolonged (3- or 7-day) intragastrical administration of omeprazole on the anticonvulsant activity of carbamazepine or diphenylhydantoin against maximal electroshock-induced seizures in mice. Omeprazole administered acutely, for 3 days or 7 days did not alter the electroconvulsive threshold in mice. Moreover, the drug did not affect the anticonvulsant activity of the tested antiepileptic drugs.
Swiader
Mariusz J
MJ
Department of Pharmacology and Toxicology, Medical University of Lublin, Lublin, Poland.
Luszczki
Jarogniew J
JJ
Pilip
Słwomir
S
Kozicka
Maria
M
Parada-Turska
Jolanta
J
Czuczwar
Stanisław J
SJ
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D002220:Carbamazepine / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D004597:Electroshock; D008297:Male; D051379:Mice; D009853:Omeprazole / Q000494:pharmacology* / Q000627:therapeutic use; D010672:Phenytoin / Q000494:pharmacology* / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin; D009853:Omeprazole