Database for three dimensional structures of pepsin-like enzymes using the internal coordinate system.
A database for 3D structures of pepsin-like enzymes has been created on the basis of a novel approach using the Internal Coordinate System (ICS). It allows rapid comparison of multiple structures of pepsin-like enzymes without the need for preliminary calculations. Atomic displacements measured by this approach are very close to those estimated by the superposition procedures widely employed in comparing three-dimensional structures of proteins. Any new structure of pepsin-like enzyme converted to the ICS automatically becomes superimposed with all structures in a database. The ICS approach can be used for any class of enzymes and is especially efficient for families containing a large number of homologous structures.
Russ
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A
V. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Pechik
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I
Andreeva
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N
D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases / Q000737:chemistry*; D002268:Carboxypeptidases / Q000737:chemistry; D030562:Databases, Protein; D010450:Endopeptidases / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010434:Pepsin A / Q000737:chemistry; D040681:Structural Homology, Protein
D053829:Amyloid Precursor Protein Secretases; D002268:Carboxypeptidases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D010434:Pepsin A