[Study on preparation technology of limonene dropping pills].
OBJECTIVE
To study the technical preparation of limonene dropping pills.


METHODS
Orthogonal test was applied to optimize the preparation of limonene dropping pills.


RESULTS
The optimized project was as follow: the matrix contained PEG4000: PEG6000 (1:1.5); the refrigerant was liquid paraffin; the rate of limonene to matrix was 1:6 and the temperature of limonene was 70 degrees C; the internal and external diameter of burette was 2.0 mm and 2.4 mm, respectively; the burette was 4cm above the surface of refrigerant; drug was dropped into refrigerant of 15 degrees C at 45 drops per minute.


CONCLUSIONS
The results provide the data for the ascertainment of shaping operation of limonene dropping pills at the manufacturing scale.
Xu
Zhenxia
Z
Pharmaceutical College, Jinan University, Guangzhou.
Gong
Ligui
L
Zhang
Aifeng
A
Wang
Huan
H
D000704:Analysis of Variance; D053138:Cyclohexenes; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000077222:Limonene; D010946:Plants, Medicinal / Q000737:chemistry*; D011108:Polymers; D027821:Rutaceae / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013729:Terpenes / Q000302:isolation & purification*; D013997:Time Factors
D053138:Cyclohexenes; D004365:Drugs, Chinese Herbal; D011108:Polymers; D013729:Terpenes; D000077222:Limonene