title: Hantavirus infection in Thailand: first clinical case report.
abstract: This study involved 115 cases of fever of unknown origin (FUO) patients who were admitted to the Department of Medicine, Siriraj Hospital from May 1999 to November 2000. Among the patient sera screened by ELISA for IgG Hantavirus, five were positive for IgG Hantavirus-reacting antibodies and eight tested positive for IgM Hantavirus-reacting antibodies. One serum had both IgG and IgM antibodies. The patient exhibited acute encephalitic febrile illness, thrombocytopenia, high AST and ALT levels, and prolonged coagulation time. It appears that a form of the Hantaan virus is circulating in Thailand, which can infect humans and be pathogenic in some instances.
authors.affiliation: Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Yupin
authors.initials: Y
authors.lastname: Suputthamongkol
authors.forename: Narong
authors.initials: N
authors.lastname: Nitatpattana
authors.forename: Methee
authors.initials: M
authors.lastname: Chayakulkeeree
authors.forename: Somnuek
authors.initials: S
authors.lastname: Palabodeewat
authors.forename: Sutee
authors.initials: S
authors.lastname: Yoksan
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Gonzalez
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D015897:Comorbidity; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology*; D006476:Orthohantavirus / Q000276:immunology* / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006760:Hospitalization; D006801:Humans; D007074:Immunoglobulin G; D012698:Serologic Tests; D013785:Thailand
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase