Hypoadiponectinemia is associated with coronary artery spasm in men.
BACKGROUND
The relationship between adiponectin and coronary spastic angina (CSA), both of which are closely involved in coronary endothelial dysfunction, has not been elucidated.


RESULTS
Plasma adiponectin concentrations were examined in 55 men with CSA and 55 with chest pain syndrome (CPS). The plasma log-adiponectin levels were significantly lower in patients with CSA than with CPS (0.61+/-0.28 vs 0.80+/-0.21 microg/ml, p < 0.0001). The prevalence of smoking was significantly higher in the CSA patients than in those with CPS (50.9% vs 29.1%, p = 0.0195). In multiple logistic regression analysis, log-adiponectin (p = 0.0008) and smoking (p = 0.0210) were independent determinants of CSA. Conclusions Hypoadiponectinemia is a potential risk factor for CSA in men, independent of smoking.
Maruyoshi
Hidetomo
H
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kojima
Sunao
S
Otsuka
Fumiyuki
F
Funahashi
Tohru
T
Kaikita
Koichi
K
Sugiyama
Seigo
S
Sakamoto
Tomohiro
T
Yoshimura
Michihiro
M
Shimomura
Iichiro
I
Ogawa
Hisao
H
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000097:blood*
D052242:Adiponectin