Loss of basement membrane heparan sulfate expression is associated with tumor progression in endometrial cancer.
Perlecan is a major heparan sulfate proteoglycan (HPSG) of the basement membrane (BM) and binds to various cytokines and growth factors via its heparan sulfate glycosaminoglycan (HS-GAG) chains. The aim of this study was to investigate BM HS-GAG expression in endometrial cancers. We investigated the expression of BM HS-GAG by immunohistochemistry in 109 endometrial cancers and analyzed correlations with various clinicopathological features. The HS-GAG expression index was significantly lower in cases of advanced stage, high-grade, deep myometrial invasion, positive peritoneal cytology, lymph vascular space invasion and lymph node metastasis. There was no association between HS-GAG expression status and patient outcome. Decreased HS-GAG expression of BM is associated with tumor progression, but is not be a useful prognostic factor in patients presenting with endometrial cancer.
Hasengaowa
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
Kodama
J
J
Kusumoto
T
T
Shinyo
Y
Y
Seki
N
N
Nakamura
K
K
Hongo
A
A
Hiramatsu
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000378:metabolism* / Q000503:physiopathology; D018196:Carcinoma, Adenosquamous / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures; D019812:Heparan Sulfate Proteoglycans / Q000096:biosynthesis*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging
D019812:Heparan Sulfate Proteoglycans; C071927:perlecan