title: Yellow fever vaccine.
abstract: Yellow fever, a mosquito-borne viral hemorrhagic fever, is one of the most lethal diseases of humankind. The etiologic agent is the prototype member of the genus Flavivirus, family Flaviviridae, a group of small, enveloped, positive-sense, single-strand RNA viruses. Approximately one in seven people who become infected develop a rapidly progressive illness, with hepatitis, renal failure, hemorrhage and cardiovascular shock, with a case fatality rate of 20-50%. Yellow fever occurs in sub-Saharan Africa and tropical South America, where it remains a continuing public health problem of varying magnitude, depending on the level of vaccination coverage in the human population and cyclical, ecologic and climatic factors that influence virus transmission.
authors.affiliation: Acambis, Inc., 38 Sidney Street, MA 02139, USA. tom.monath@acambis.com
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Monath
mesh_terms: D000818:Animals; D006801:Humans; D015004:Yellow Fever / Q000276:immunology / Q000517:prevention & control*; D022341:Yellow Fever Vaccine / Q000627:therapeutic use*; D015005:Yellow fever virus / Q000276:immunology*
chemical_list: D022341:Yellow Fever Vaccine