Chemiluminescence micro-flow-injection analysis on a chip.
Chemiluminescence microflow-injection analysis (microFIA) systems on a chip have been developed. The technology of laser ablation was used to fabricate the microchannels on the polymethyl methacrylate (PMMA) chip. The three sampling structure, including double-tee sampling structure, microvalve sampling structure and injection pump with accurate time control, were used. The microcolumn for specific molecular recognition, including molecularly imprinted polymer, enzyme and bacteria, were used to enhance selectivity. These microFIA systems have been applied to clinical analysis, assessment of food safety, in vivo and real-time determination of drugs, and pharmacokinetics studies.
Zhang
Zhujun
Z
Department of Chemistry, Shaanxi Normal University, XiAn, Shaanxi 710062, People's Republic of China. zzj18@hotmail.com
He
Deyong
D
Liu
Wei
W
Lv
Yi
Y
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D002857:Chromium / Q000097:blood / Q000378:metabolism; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D056656:Lab-On-A-Chip Devices; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D046208:Microchip Analytical Procedures / Q000379:methods*; D011817:Rabbits; D014527:Uric Acid / Q000032:analysis
D002857:Chromium; D014527:Uric Acid