Retrospective analysis of predictive factors for recurrence after curatively resected papillary thyroid carcinoma.
OBJECTIVE
This retrospective study analyzes the predictive factors after curative surgery for papillary thyroid carcinoma (PTC).


METHODS
We analyzed 386 patients who underwent a curative operation for PTC in our hospital between 1977 and 1997, subject to the inclusion criteria.


RESULTS
According to univariate analysis, pathological lateral cervical lymph node involvement (P < 0.0001), dedifferentiation of the tumor (P < 0.002), male sex (P < 0.0001), a large tumor (P < 0.005), and an age of over 50 years (P < 0.05) were significant factors. Cox's proportional hazard model showed that a man (P < 0.05), aged over 50 years (P < 0.05), who had a large primary tumor (P < 0.05) with dedifferentiation (P < 0.05), and pathological lateral cervical lymph node metastasis (P < 0.005) was more likely to have recurrence of PTC.


CONCLUSIONS
Determining whether lymph node metastasis exists could be useful for predicting recurrence in patients who have undergone curative resection of PTC.
Tanaka
Katsuhiro
K
Department of Breast and Thyroid Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.
Sonoo
Hiroshi
H
Hirono
Mai
M
Ohkubo
Sumiko
S
Nomura
Tsunehisa
T
Ikeda
Masahiko
M
Nakajima
Kazukata
K
Kurebayashi
Junichi
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome