title: [Does disulfiram still have a role in alcoholism treatment?].
abstract: What is the place of disulfiram in the treatment of alcohol dependence since anti-craving pharmacological molecules (acamprosate, naltrexone) were launched on the market? Considering methodological limitations, available studies do not allow to conclude about disulfiram's efficacy. Clinical observations indicate however that disulfiram should keep a place in the treatment of alcohol-dependence considering favourable outcome for some patients. Disulfiram implants have however to be avoided. Side effects and possible adverse reactions should not be a barrier to its use. Disulfiram shouldn't be given during pregnancy and to patients with instable cardio-vascular disease. Its prescription justifies a close monitoring of liver tests for patients with abnormal hepatic function.
authors.affiliation: CTA-MP16, CHUV, 1011 Lausanne.
authors.forename: M
authors.initials: M
authors.lastname: Blanc
authors.forename: J-B
authors.initials: JB
authors.lastname: Daeppen
mesh_terms: D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000534:rehabilitation*; D004221:Disulfiram / Q000627:therapeutic use*; D004343:Drug Implants; D006801:Humans
chemical_list: D000427:Alcohol Deterrents; D004343:Drug Implants; D004221:Disulfiram