[Polymorphism research on the distribution of four HLA alleles in five Chinese populations].
ARMS-SSP PCR was applied to survey the distribution of four AIDS associated HLA alleles, HLA-A*02, B*35, B*27, and B*57 in five Chinese nationalities (Yunnan han, yi, dai, Xinjiang uygur, and Guangxi zhuang). The results showed that HLA-A*02 allele occured very frequently at higher frequencies in han and zhuang than in the other three nationalities; B*35 did not show great variation in it's distribution in five population groups; B*27 had a distinctively high frequency in dai, but normal in han, yi and zhuang; B*57 allele did not vary greatly in these nationalities, too. A*02, B*27 and B*57 are three protective alleles. As a whole, their frequencies in the five nationalities were significantly different. This study could be a complement of the HLA and AIDS relative studies, and enhanced the understanding of the genetic background of some AIDS epidemic regions in China.
Xiao
Wen-Yan
WY
Department of Genetics, Institute of Medical Biology, Pekin Union Medical College, Kunming 650118, China. wy_jessie@tom.com
Chu
Jia-You
JY
Shi
Lei
L
Yu
Jian-Kun
JK
Xu
Shao-Bing
SB
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic
D015234:HLA-A Antigens; D015235:HLA-B Antigens