Development of new cycloaddition reactions based on the unique reactivity of unsaturated hydrocarbons.
We discovered that the reactivity of some conjugated and electron-deficient hydrocarbons was quite different in the presence of transition metal catalysts. In this review we report our development and applications of the highly selective palladium and nickel-catalyzed cycloaddition reactions of unsaturated hydrocarbons such as conjugated enynes, electron-deficient allenes, and electron-deficient methylenecyclopropanes. Some homocoupling reactions as well as co-cyclization reactions were described. The efficient synthesis of 4--7 membered carbocycles was achieved.
Saito
Shinichi
S
Department of Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku, Tokyo, Japan. ssaito@rs.kagu.tus.ac.jp
D002384:Catalysis; D003500:Cyclization; D006838:Hydrocarbons / Q000737:chemistry*; D007202:Indicators and Reagents; D009532:Nickel; D010165:Palladium
D006838:Hydrocarbons; D007202:Indicators and Reagents; D010165:Palladium; D009532:Nickel