Effect on ocular survival of adding early intensive focal treatments to a two-drug chemotherapy regimen in patients with retinoblastoma.
OBJECTIVE
To evaluate vincristine and carboplatin with intensive focal treatments in the management of intraocular retinoblastoma.


METHODS
Noncomparative, retrospective interventional case series.


METHODS



METHODS
Institutional.


METHODS
Sixteen patients (11 bilateral, 5 unilateral) with intraocular retinoblastoma. Interventional procedures: Patients were treated with eight courses of vincristine and carboplatin. Intensive focal treatments were administered after two courses of chemotherapy.


METHODS
Avoidance of external beam radiotherapy (EBRT) and eye survival.


RESULTS
Twenty eyes (74.1%) were classified as Reese-Ellsworth Group V. All eyes responded to chemotherapy. With a median follow-up of 23 months (range 10 to 33 months) and a median of 5.5 focal treatments per eye (range 0 to 19 treatments), ocular survival was 81%. Eight eyes (30%) in five patients received EBRT.


CONCLUSIONS
Vincristine and carboplatin combined with intensive focal treatments is an effective regimen for patients with intraocular retinoblastoma. This treatment regimen has outcomes comparable to those of more toxic regimens and merits further evaluation.
Wilson
Matthew W
MW
Department of Ophthalmology, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA. mwilson5@utmem.edu
Haik
Barrett G
BG
Liu
Tiebin
T
Merchant
Thomas E
TE
Rodriguez-Galindo
Carlos
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001918:Brachytherapy; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D017679:Cryotherapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D017075:Laser Coagulation; D008297:Male; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D012175:Retinoblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
D007457:Iodine Radioisotopes; D014750:Vincristine; D016190:Carboplatin