Inhibition of cyclo-oxygenase-2 expression in mouse macrophages by 4-(3-methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene, a resveratrol derivative from peanuts.
Resveratrol derivatives are of interest as inhibitors of cyclo-oxygenase-2 and as antiinflammatory agents. The prenylated resveratrol derivative 4-(3-methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene was purified from fungally infected peanuts by thin layer chromatography and its structure was confirmed by mass spectrometry. 4-(3-Methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene inhibited lipopolysaccharide-induced expression of cyclo-oxygenase-2 protein and cyclo-oxygenase-2 mRNA in mouse macrophages at concentrations that were non-cytotoxic. 4-(3-Methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene warrants further evaluation as an antiinflammatory agent.
Patel
Bankim
B
Department of Life Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Patel
Sandip
S
Hoffman
Richard
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010367:Arachis / Q000382:microbiology; D015153:Blotting, Western; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects*; D012333:RNA, Messenger / Q000378:metabolism; D000077185:Resveratrol; D012639:Seeds; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D008070:Lipopolysaccharides; D010936:Plant Extracts; D012333:RNA, Messenger; D013267:Stilbenes; D011451:Prostaglandin-Endoperoxide Synthases; D000077185:Resveratrol