Primary intracranial dural lymphoma of mucosa-associated lymphoid tissue (MALT) type: report of one case and review of the literature.
Primary indolent leptomeningeal lymphoma is a rare entity, and corresponds in most cases to mucosa-associated lymphoid tissue (MALT) type lymphoma. We are reporting a case of a 75 years old woman, who presented with a 2-year history of behavioral disorder, progressive memory loss and aphasia. Neuroimaging showed a mass infiltrating the frontal circumvolutions and the roof of the orbit. The biopsy revealed an infiltration of the dura by an indolent lymphoma, characteristic of a MALT-type lymphoma. Complete staging work-up did not show any evidence of systemic involvement. A treatment with systemic methotrexate, combined with intrathecal chemotherapy and followed by radiotherapy (30,6 Gy) of the primary site, was conducted. The 3-year follow-up confirms the persistent remission, the patient remaining well and free of symptoms. The review of the literature highlights the importance to recognize the indolent PLML as a distinct clinical entity, which exhibits a rather good prognosis following a relatively non-toxic therapy.
George
Anne-Claude
AC
Department of Oncology and Haematology, Pluridisciplinary Center for Oncology, CHUV, BH-06, 1011 Lausanne, Switzerland.
Ozsahin
Mahmut
M
Janzer
Robert
R
Agassis
Siverio
S
Meuli
Reto
R
Baur
Audrey S
AS
Frossard
Valérie
V
Leyvraz
Serge
S
Ketterer
Nicolas
N
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D004388:Dura Mater; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D018442:Lymphoma, B-Cell, Marginal Zone / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000628:therapy; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000473:pathology* / Q000628:therapy; D008727:Methotrexate / Q000008:administration & dosage
D003561:Cytarabine; D006854:Hydrocortisone; D008727:Methotrexate