title: Effect of medium age and supplementation with the biocatalytic oxygen-reducing reagent oxyrase on in vitro activities of tigecycline against recent clinical isolates.
abstract: In determining the quality control limits for the Clinical Laboratory Standards Institute-recommended quality control organisms with tigecycline, a number of inconsistencies in the results were encountered that appeared to be related to the age of the Mueller-Hinton broth II. This study was performed to examine the effect of medium age and supplementation with Oxyrase on the activity of tigecycline using a large number of clinical isolates.
authors.affiliation: Infectious Disease Research, Wyeth Research, Bldg. 200, Rm. 3301, 401 N. Middletown Rd., Pearl River, NY 10965, USA. petersp@wyeth.com
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Petersen
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Bradford
mesh_terms: D002384:Catalysis; D003470:Culture Media / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010105:Oxygenases / Q000494:pharmacology*; D000078304:Tigecycline
chemical_list: D003470:Culture Media; D000078304:Tigecycline; D010105:Oxygenases; C072755:Oxyrase; D008911:Minocycline; D010100:Oxygen