Ultimate success in epilepsy--the patient's perspective.
Most people with epilepsy can live outwardly normal lives, but fear about impending seizures, driving restrictions, lack of independence, employment and social problems, medication-related adverse effects and the presence of cognitive or psychiatric complications are all concerns readily identified by affected individuals. While seizure control is the overriding goal of treatment, it is essential to realize the importance that patients place on other aspects of daily functioning. While many of the concerns identified by patients can only be managed by improved social support, others (e.g. neuropsychological impairment, medication-related adverse events, cognitive impairment, sleep disturbance) may be amenable to therapy (if available) or to the selection of a more appropriate antiepileptic drug. Each antiepileptic drug has a unique pharmacodynamic and tolerability profile. Awareness by the treating clinician of the pharmacological profile of each drug may help to minimize unwanted treatment-related effects and possibly improve the outcome of treatment from an epilepsy patient's perspective. Therefore, in order to achieve true treatment success, clinicians need to understand how individuals perceive their disorder and, where possible, address those factors that adversely affect patient quality of life. For the person with epilepsy, successful treatment involves beneficial effects on social, vocational and psychological function. This extends beyond seizure control to freedom from the fear associated with seizures, confidence in pharmacological therapy and improvements in health-related quality of life.
Sander
J W
JW
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK. l.sander@ion.ucl.ac.uk
D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001294:Attitude to Health; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D011788:Quality of Life; D012640:Seizures / Q000517:prevention & control; D018434:Sickness Impact Profile; D012893:Sleep Wake Disorders / Q000209:etiology
D000927:Anticonvulsants