In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma.
Ten phenylethanoid glycosides, forsythoside B, acteoside, 2'-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM.
Koo
Kyung Ah
KA
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
Sung
Sang Hyun
SH
Park
Jong Hee
JH
Kim
Seung Hyun
SH
Lee
Ki Yong
KY
Kim
Young Choong
YC
D000818:Animals; D032408:Callicarpa; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D018698:Glutamic Acid; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems; D051381:Rats; D017207:Rats, Sprague-Dawley
D006027:Glycosides; D018696:Neuroprotective Agents; D010936:Plant Extracts; D018698:Glutamic Acid