title: [Effects of aspiration of airway dead space on blood gases and respiratory mechanics in acute hypercapnia model dogs].
abstract: OBJECTIVE
  To establish the method of aspiration of airway dead space (ASPIDS) and evaluate the effects of ASPIDS on elimination of CO2 and improvement of ventilation efficiency.
  
  
  METHODS
  Using self-designed ASPIDS device, physiological parameters such as PaCO2, P(peak), P(pause), end expiratory carbon dioxide pressure (PaCO2), lung statistic compliance (Cst), respiratory resistance (Re) and hemodynamics in two animal groups of conventional mechanical ventilation (CMV) and hypercapnia (HC) were observed by applying tracheal gas insufflation (TGI 4.0 L/min) and ASPIDS (4.0 L/min).
  
  
  RESULTS
  ASPIDS significantly decreased PaCO2 level, enhanced CO2 elimination and maintained PaCO in normal range while decreased VT by 30%, the elimination of CO2 of ASPIDS was superior to that of TGI. ASPIDS significantly decreased airway pressure in both animal groups . P(et)CO2 and Re levels significantly decreased after ASPIDS. ASPIDS showed no influence on Cst, hemodynamics and oxygenation.
  
  
  CONCLUSIONS
  The ASPIDS device is a simple and practical adjunct method to mechanical ventilation, it can more effectively decrease PaCO2 than TGI, and maintain lower airway pressure.
authors.affiliation: Department of Respiratory Medicine, General Hospital of PLA, Beijing 100853, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: D
authors.initials: D
authors.lastname: Gao
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics; D006935:Hypercapnia / Q000097:blood* / Q000503:physiopathology* / Q000628:therapy*; D007327:Insufflation; D008297:Male; D012121:Respiration, Artificial / Q000379:methods*; D012126:Respiratory Dead Space / Q000502:physiology; D013396:Suction / Q000295:instrumentation* / Q000379:methods
chemical_list: D002245:Carbon Dioxide