Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats.
We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.
Lazić
Ratimir
R
Eye Clinic, Svjetlost, Zagreb, Croatia. ratimir.lazic@zg.htnet.hr
Gabrić
Nikica
N
Dekaris
Iva
I
Bosnar
Damir
D
Boban-Blagaić
Alenka
A
Sikirić
Predrag
P
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000662:veterinary; D004848:Epithelium; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D010446:Peptide Fragments; D011506:Proteins; C083833:BPC 157