title: Effective training for patients with intermittent claudication.
abstract: OBJECTIVE
  Current guidelines for treatment of intermittent claudication (IC) do not include a specific recommendation for the intensity of exercise therapy. Thus, the purpose of this study was to determine the relative effectiveness of high versus low intensity exercise for patients with IC, and further to study the effect of such training on blood flow to the legs during exercise.
  
  
  METHODS
  The effect of eight weeks of supervised endurance training was examined in 16 patients with IC. The patients were randomly assigned to training at intensities corresponding to either 60% or 80% of their peak oxygen consumption (VO2peak), respectively.
  
  
  RESULTS
  VO2peak and time to exhaustion increased significantly (9% and 16%, respectively) more in the high intensity group (p<0.05). Blood flow to the legs did not change after training in any of the groups.
  
  
  CONCLUSIONS
  High intensity training gave larger improvements in VO2peak and time to exhaustion than low intensity training. As blood flow did not change after the exercise program, it is likely that the observed different increase of VO2peak was due to changed mitochondrial oxidative capacity and/or skeletal muscle diffusive capacity.
authors.affiliation: Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. stig.slordahl@ntnu.no
authors.forename: Stig A
authors.initials: SA
authors.lastname: Slørdahl
authors.forename: Eivind
authors.initials: E
authors.lastname: Wang
authors.forename: Jan
authors.initials: J
authors.lastname: Hoff
authors.forename: Ole J
authors.initials: OJ
authors.lastname: Kemi
authors.forename: Brage H
authors.initials: BH
authors.lastname: Amundsen
authors.forename: Jan
authors.initials: J
authors.lastname: Helgerud
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D005080:Exercise Test; D005081:Exercise Therapy; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007383:Intermittent Claudication / Q000503:physiopathology / Q000628:therapy*; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D016896:Treatment Outcome