title: Weight change in monozygotic twins treated with valproate.
abstract: OBJECTIVE
  To evaluate whether genetic factors contribute to weight gain associated with valproate (VPA) therapy.
  
  
  METHODS
  We retrospectively and prospectively evaluated five pairs of monozygotic twins concordant for epilepsy and treated with VPA regarding weight course.
  
  
  RESULTS
  In all twin pairs, both twins showed similar weight courses under therapy with VPA.
  
  
  CONCLUSIONS
  These results suggest that genetic factors may have an influence on the weight change induced by VPA. Further studies are necessary to obtain heritability estimates regarding this effect of VPA therapy and to identify the relevant genes.
authors.affiliation: Interdisciplinary Epilepsy Center, Department of Neurology, Philipps-University Marburg, 35033 Marburg, Germany.
authors.forename: Karl Martin
authors.initials: KM
authors.lastname: Klein
authors.forename: Hajo M
authors.initials: HM
authors.lastname: Hamer
authors.forename: Janine
authors.initials: J
authors.lastname: Reis
authors.forename: Jörg
authors.initials: J
authors.lastname: Schmidtke
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Frank M
authors.initials: FM
authors.lastname: Theisen
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.forename: Felix
authors.initials: F
authors.lastname: Rosenow
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002675:Child, Preschool; D004200:Diseases in Twins / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D004827:Epilepsy / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000209:etiology / Q000235:genetics / Q000473:pathology; D012307:Risk Factors; D014430:Twins, Monozygotic / Q000235:genetics; D014635:Valproic Acid / Q000009:adverse effects*; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid