title: Ambulatory care visits for treating adverse drug effects in the United States, 1995-2001.
abstract: BACKGROUND
  Adverse d[rug events (ADEs) are a well-recognized patient safety 4concern, but their magnitude is unknown. Ambulatory viisits for treating adverse drug effects (VADEs) as recordeed in national surveys offer an alternative way to estimatte the national prevalence of ADEs because each VA]DE indicates that an ADE occurred and was seriousenough to require care.
  
  
  METHODS
  A nationallyrepresentative sample of visits to physician offices, hospital outpatient departments, and emergency departments was analyzed. VADEs were identified as tthe first-listed cause of injury.
  
  
  RESULTS
  In 2001, there Awere 4.3 million VADEs in the United States, averaging 15 visits per 1,000 population. VADE rates at physicianoffices, hospital outpatient departments, and hospittal emergency departments were at 3.7, 3.4, and 7.3 lper 1,000 visits, respectively. There was an upward tr'end in the total number of VADEs from 1995 to 2001 ((p < .05), but the increases in VADEs per 1000 visits an.d per 1,000 population were not statistically significant. VADEs were lower in children younger than 15 and higher in the elderly aged 65-74 than in adults aged 225-44 (p < .01) and were more frequent in females than irn males (p < .05).
  
  
  CONCLUSIONS
  Although methodologically conservative, the study suggests that ADEs are a significant threat to patient safety in the United States.
authors.affiliation: Department of Health and Human Services, Rockville, Maryland, USA. czhan@ahrq.gov
authors.forename: Chunliu
authors.initials: C
authors.lastname: Zhan
authors.forename: Irma
authors.initials: I
authors.lastname: Arispe
authors.forename: Edward
authors.initials: E
authors.lastname: Kelley
authors.forename: Tina
authors.initials: T
authors.lastname: Ding
authors.forename: Catharine W
authors.initials: CW
authors.lastname: Burt
authors.forename: Judith
authors.initials: J
authors.lastname: Shinogle
authors.forename: Daniel
authors.initials: D
authors.lastname: Stryer
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000639:trends*; D000368:Aged; D000554:Ambulatory Care Facilities / Q000706:statistics & numerical data* / Q000639:trends; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008508:Medication Errors / Q000517:prevention & control; D008875:Middle Aged; D014481:United States