Sclerosing panniculitis is associated with pulmonary hypertension in systemic sclerosis.
BACKGROUND
There have been no reports of patients with sclerosing panniculitis and systemic sclerosis (SSc).


OBJECTIVE
To evaluate the incidence of sclerosing panniculitis in patients with SSc, and to investigate the clinical features of such cases.


METHODS
In total, 128 patients with SSc treated at our clinic were investigated retrospectively.


RESULTS
SSc patients with sclerosing panniculitis had pulmonary hypertension (PH), especially isolated PH, at a significantly higher incidence than those without. Among the SSc patients with PH, those with sclerosing panniculitis had pulmonary infarctions at a higher incidence than those without.


CONCLUSIONS
Our results suggest that thrombosis caused by venous hypertension of the leg may be the main cause of PH in patients with SSc and sclerosing panniculitis. Sclerosing panniculitis may be a useful marker of PH in patients with SSc.
Jinnin
M
M
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan.
Ihn
H
H
Asano
Y
Y
Yamane
K
K
Yazawa
N
N
Tamaki
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D004452:Echocardiography; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000000981:diagnostic imaging; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015434:Panniculitis / Q000150:complications* / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000150:complications / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000150:complications* / Q000000981:diagnostic imaging; D018709:Statistics, Nonparametric
D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid