Centrosome duplication and nematodes: recent insights from an old relationship.
Centrosome duplication is required for proper cell division, and centriole formation is a key step in this process. This review discusses recent studies in C. elegans that have identified five core proteins required for centriole formation, thus shedding light into the mechanisms underlying centrosome duplication in nematodes and beyond.
Leidel
Sebastian
S
Swiss Institute for Experimental Cancer Research (ISREC), Lausanne.
Gönczy
Pierre
P
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000378:metabolism / Q000648:ultrastructure; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism; D002502:Centrioles / Q000378:metabolism / Q000648:ultrastructure; D018385:Centrosome / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; C472409:SAS-4 protein, C elegans; C488496:SAS-5 protein, C elegans; C497201:SAS-6 protein, C elegans; C486131:SPD-2 protein, C elegans; D011494:Protein Kinases; C429649:zyg-1 protein, C elegans