Contrast dose-to-creatinine clearance ratio as a potential indicator of risk for radiocontrast-induced nephropathy: correlation of D/CrCL with area under the contrast concentration-time curve using iodixanol.
OBJECTIVE
Identification of risk factors is important for preventing radiocontrast-induced nephropathy (RCIN). Contrast dose and renal function have been shown in most but not all studies to be risk factors for RCIN. We are investigating the ratio of contrast dose to creatinine clearance (D/CrCL) as a risk indicator. Theory shows that the D/CrCL ratio equals the area under the concentration-time curve (AUC), an accepted measure of systemic exposure. This study investigated the correlation between calculated D/CrCL and experimentally measured AUC for the contrast agent iodixanol.


METHODS
Experimental data on AUC from a phase 1 study of iodixanol were plotted against the D/CrCL ratio and the degree of correlation was determined.


RESULTS
Experimentally determined AUC data correlate highly with the D/CrCL ratio.


CONCLUSIONS
The D/CrCL ratio is a rapid and accurate way to estimate AUC for an iodinated x-ray contrast agent without the need for multiple blood samples.
Sherwin
Paul F
PF
GE Healthcare, Princeton, New Jersey 08540, USA. PaulSherwin@ge.com
Cambron
Richard
R
Johnson
Judith A
JA
Pierro
Joseph A
JA
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000009:adverse effects / Q000493:pharmacokinetics*; D003404:Creatinine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D016018:Least-Squares Analysis; D008657:Metabolic Clearance Rate; D012307:Risk Factors; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000493:pharmacokinetics*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003404:Creatinine; C044834:iodixanol