title: Phyllodes tumor of borderline malignancy: seven year follow up with immunohistochemical study.
abstract: The patient was 80 years old when she initially presented with a left breast mass. Originally, a needle biopsy showed benign stromal and ductal cells. Five years later, the breast mass increased in size and a core needle biopsy showed a biphasic intraductal papillomatous tumor with cellular stroma. Eighteen months later, another biopsy was taken from the breast mass, revealing a well-developed phyllodes tumor (PT) of borderline malignancy. One month later, a simple mastectomy was performed for this 87-year-old woman. Histolopathologic and immunohistochemical studies, including estrogen and progesterone receptors, Ki-67 and p53, performed on tissues from the different biopsy specimens confirmed the progressive transition of the tumor in a 7 year period. An increase in mitotic activity was noted in the later samples. Similarly, percentages of p53- and Ki-67-positive cells were much higher in the stromal and ductal cells of the later samples compared to the original specimen. These findings support the notion that Ki-67 and p53 immunohistochemical staining may be used as simple and practical markers for the evaluation of the malignant potential of PT.
authors.affiliation: Division of Surgical Pathology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. tomitat@ohsu.edu
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Tomita
authors.forename: Yafei
authors.initials: Y
authors.lastname: Ren
authors.forename: Marilyn
authors.initials: M
authors.lastname: Davis
authors.forename: Ossama
authors.initials: O
authors.lastname: Tawfik
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015413:Mastectomy, Simple; D008938:Mitosis; D003557:Phyllodes Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor