title: Biofunctionalization of fluorescent-magnetic-bifunctional nanospheres and their applications.
abstract: Hydrazide-containing bifunctional nanospheres were covalently coupled on the surface with IgG, avidin, and biotin, to generate novel fluorescent-magnetic-biotargeting trifunctional nanospheres, which can be used in a number of biomedical applications, including visual sorting and manipulation of apoptotic cells as demonstrated here.
authors.affiliation: College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, Wuhan University, Wuhan 430072, P. R. China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Wang
authors.forename: Er-Qun
authors.initials: EQ
authors.lastname: Song
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Xie
authors.forename: Zhi-Ling
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Tian
authors.forename: Chao
authors.initials: C
authors.lastname: Zuo
authors.forename: Dai-Wen
authors.initials: DW
authors.lastname: Pang
authors.forename: Dao-Cheng
authors.initials: DC
authors.lastname: Wu
authors.forename: Yun-Bo
authors.initials: YB
authors.lastname: Shi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D017304:Annexin A5; D017209:Apoptosis / Q000528:radiation effects; D001360:Avidin / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D002853:Chromatography, Liquid; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G / Q000737:chemistry; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D000447:Aldehydes; D017304:Annexin A5; D005456:Fluorescent Dyes; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D001360:Avidin; D001710:Biotin; D016650:Fluorescein-5-isothiocyanate