title: [Clinical, radiographic and laboratory evaluation of patients with osteogenesis imperfecta].
abstract: BACKGROUND
  Osteogenesis imperfecta is a genetic disorder characterized by defects in type I collagen. The main symptom is bone fragility and susceptibility to fractures. Other clinical findings are dentinogenesis imperfecta, blue sclera, early deafness and joint laxity. The purpose of this paper is to establish a practical relationship of the clinical differences between the Sillence's groups.
  
  
  METHODS
  22 patients were classified according to Sillence et al criteria and submitted to laboratory tests including blood calcium level and bone densitometry.
  
  
  RESULTS
  All clinical and laboratory differences were discussed in the text.
  
  
  CONCLUSIONS
  Differences such as results that were found in walking ability, height and bone densitometry were significant and may help to classify patients and to establish prognosis.
authors.affiliation: Grupo de Ortopedia Pediátrica, Departamento de Ortopedia e Traumatologia, Hospital Central da Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo (SP), Brazil. c.santili@terra.com.br
authors.forename: Cláudio
authors.initials: C
authors.lastname: Santili
authors.forename: Miguel
authors.initials: M
authors.lastname: Akkari
authors.forename: Gilberto
authors.initials: G
authors.lastname: Waisberg
authors.forename: José Olympio Catão
authors.initials: JO
authors.lastname: Bastos Júnior
authors.forename: William Martins
authors.initials: WM
authors.lastname: Ferreira
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001827:Body Height; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003811:Dentinogenesis Imperfecta / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010013:Osteogenesis Imperfecta / Q000145:classification / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011379:Prognosis; D012590:Sclera / Q000002:abnormalities; D012737:Sex Factors; D018709:Statistics, Nonparametric
chemical_list: D002118:Calcium