Infectivity of Plasmodium falciparum gametocytes to Anopheles arabiensis after treatment with sulfadoxine-pyrimethamine.
Sulfadoxine-pyrimethamine induces increased gametocytaemia when used for treating Plasmodium falciparum malaria. Laboratory-reared Anopheles arabiensis mosquitoes were fed with blood from patients with post-therapeutic gametocytaemia using a membrane feeder. Fourteen days later the heads and thoraxes of 613 mosquitoes were negative for P. falciparum sporozoites by enzyme-linked immunosorbent assay.
Govere
J M
JM
Communicable Disease Control, Mpumalanga Department of Health, Nelspruit 1200, South Africa. goverej@whoafr.org
Durrheim
D N
DN
Mngomezulu
N M
NM
Barnes
K
K
Sharp
B
B
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D000962:Antimalarials / Q000494:pharmacology*; D004338:Drug Combinations; D005718:Gametogenesis; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000635:transmission; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology*; D013413:Sulfadoxine / Q000494:pharmacology*
D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine