title: [Changes of the expression of beta1-adrenergic receptor and M2-muscarinic acetylcholine receptor in rat hearts after high power microwave radiation].
abstract: OBJECTIVE
  To investigate the effect of high power microwave (HPM) radiation on the expression of beta(1)-adrenergic receptor (beta(1)-AR) and M(2)-muscarinic acetylcholine receptor (M(2)-AchR) in cardiomyocytes.
  
  
  METHODS
  S-band HPM device of mean power density 2 approximately 90 mW/cm(2) was used to irradiate 150 healthy Wistar male rats. Immunohistochemistry and image analysis were used to study the pathological characteristics of heart tissue and the expression of beta(1)-AR and M(2)-AchR.
  
  
  RESULTS
  Radiation of over 10 mW/cm(2) made myocardial fibers disordered in arrangement, degeneration even sarcoplasm condensation, Pace cells necrosis, and Purkinje cells lysis in a dose-dependent manner (r = 0.968, P < 0.05). beta(1)-AR expression in endocardium, membrane and cytoplasm of myocardium of left ventricle was increased on d1 after radiation, peaked on d3 (P < 0.05) and recovered on d14. M(2)-AchR expression was peaked on d1 (P < 0.01) and recovered on d14.
  
  
  CONCLUSIONS
  Certain degree intensity of HPM radiation may cause heart injury, and increased expressions of beta(1)-AR and M(2)-AchR, which may play an important role in the pathophysiology of heart injury induced by HPM.
authors.affiliation: Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Min-hong
authors.initials: MH
authors.lastname: Pan
authors.forename: Rui-yun
authors.initials: RY
authors.lastname: Peng
authors.forename: Ya-bing
authors.initials: YB
authors.lastname: Gao
authors.forename: Shui-ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Jun-jie
authors.initials: JJ
authors.lastname: Ma
authors.forename: De-wen
authors.initials: DW
authors.lastname: Wang
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Hu
authors.forename: Zhen-tao
authors.initials: ZT
authors.lastname: Su
authors.forename: Guo-shan
authors.initials: GS
authors.lastname: Yang
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006321:Heart / Q000528:radiation effects*; D008297:Male; D008872:Microwaves / Q000009:adverse effects*; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D043585:Receptor, Muscarinic M2 / Q000096:biosynthesis*; D018342:Receptors, Adrenergic, beta-1 / Q000096:biosynthesis*
chemical_list: D043585:Receptor, Muscarinic M2; D018342:Receptors, Adrenergic, beta-1