Gene expression profile analysis of Porphyromonas gingivalis during invasion of human coronary artery endothelial cells.
Microarrays were used to identify genes of Porphyromonas gingivalis W83 differentially expressed during invasion of primary human coronary artery endothelial cells. Analyses of microarray images indicated that 62 genes were differentially regulated. Of these, 11 genes were up-regulated and 51 were down-regulated. The differential expression of 16 selected genes was confirmed by real-time PCR.
Rodrigues
Paulo H
PH
Department of Oral Biology, University of Florida, P.O. Box 100424, Gainesville, FL 32610-0424, USA.
Progulske-Fox
Ann
A
D016866:Bacteroidaceae Infections / Q000378:metabolism*; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000382:microbiology*; D015536:Down-Regulation / Q000276:immunology; D004730:Endothelium, Vascular / Q000166:cytology / Q000382:microbiology*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial / Q000276:immunology; D006801:Humans; D016966:Porphyromonas gingivalis / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation / Q000276:immunology