[Expression of p27 in renal interstital fibrosis in rats induced by unilateral ureteral obstruction].
OBJECTIVE
To explore the role of p27 in the renal tubule on the process of renal interstitial fibrosis caused by unilateral ureteral obstruction (UUO) in rats.


METHODS
Rats were killed at the 7th, 14th, 21st days after UUO or sham-surgery. The protein expression of p27 in renal tubule was detected by immuohistochemistry at each time point.


RESULTS
At the 7th day after the surgery, no noticeable abnormalities of p27 expression were found in renal tubular cells between UUO and the sham operated surgery. At the 14th and 21st days after UUO, the p27 expressions in renal tubular cells obviously decreased compared with those after the sham operated surgery.


CONCLUSIONS
The p27 expression has no noticeable changes in the early UUO rats, and then it was significantly reduced with the renal interstitial fibrosis progressing.
Tao
Li-Jian
LJ
Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
Sun
Jian
J
Jin
Ou
O
D000818:Animals; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D007684:Kidney Tubules / Q000378:metabolism; D009400:Nephrosclerosis / Q000209:etiology / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014517:Ureteral Obstruction / Q000150:complications*
D050760:Cyclin-Dependent Kinase Inhibitor p27