Sodwanone S, a triterpene from the marine sponge Axinella weltneri.
The bioassay-guided fractionation of the crude extract of the marine sponge Axinella weltneri led to the isolation and the identification of a new triterpene named sodwanone S (1), with an uncommon oxepane-cyclohexane system, along with the known sodwanones A and G. The structure was elucidated using spectroscopic data, and the biological activity was evaluated against 13 human tumor cell lines. A biogenetic pathway of this new compound is also proposed.
Funel-Le Bon
Corinne
C
Laboratoire de Chimie Bioorganique, UMR 6001 CNRS, Faculté des Sciences, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.
Berrué
Fabrice
F
Thomas
Olivier P
OP
Reyes
Fernando
F
Amade
Philippe
P
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D014315:Triterpenes; C504676:sodwanone S