title: Immunosuppression by T regulatory cells in cows infected with Staphylococcal superantigen.
abstract: Our recent study has provided that the in vitro SEC-induced proliferation of bovine T cells is preceded by a period of a non-proliferative immunoregulation of T cells that may be associated with cytokine production regulated by type 1 or type 2 T cells. Inversion of CD4(+):CD8(+) T cell ratio and induction of CD8(+) T cells with immunoregulatory activity could increase the probability of intracellular survival of Staphylococcus aureus (S. aureus). The increase of activated CD8(+)(ACT2(+) BoCD8(+)) T cells in cows with mastitis caused by S. aureus may be associated with immune-regulatory function in the bovine mammary gland. The difference and similarity between bovine activated CD8(+) T cells (CD8(+)CD26(+)) and well-established human CD4(+)CD25(+) T regulatory (Tr) cells may help to reveal their unique immune regulatory system in the host infected with S. aureus.
authors.affiliation: Animal Health Research, LG Life Sciences Ltd., Daejeon, Korea.
authors.forename: Byoung Sun
authors.initials: BS
authors.lastname: Chang
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Bohach
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Lee
authors.forename: William C
authors.initials: WC
authors.lastname: Davis
authors.forename: Lawrence K
authors.initials: LK
authors.lastname: Fox
authors.forename: Witold A
authors.initials: WA
authors.lastname: Ferens
authors.forename: Keun Seok
authors.initials: KS
authors.lastname: Seo
authors.forename: Hye Cheong
authors.initials: HC
authors.lastname: Koo
authors.forename: Nam Hoon
authors.initials: NH
authors.lastname: Kwon
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Park
mesh_terms: D000818:Animals; D002417:Cattle; D049109:Cell Proliferation; D005260:Female; D008213:Lymphocyte Activation / Q000276:immunology; D008414:Mastitis, Bovine / Q000276:immunology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology / Q000662:veterinary*; D013210:Staphylococcus / Q000276:immunology*; D018089:Superantigens; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D018089:Superantigens