Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data.
The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS.
Sastre-Garriga
J
J
Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK.
Ingle
G T
GT
Rovaris
M
M
Téllez
N
N
Jasperse
B
B
Altmann
D R
DR
Benedetti
B
B
Stevenson
V L
VL
Cercignani
M
M
Leary
S M
SM
Barkhof
F
F
Brochet
B
B
Dousset
V
V
Filippi
M
M
Montalban
X
X
Kalkers
N F
NF
Polman
C H
CH
Rovira
A
A
Miller
D H
DH
Thompson
A J
AJ
D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002490:Central Nervous System / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D003625:Data Collection; D038524:Diffusion Magnetic Resonance Imaging / Q000592:standards; D004185:Disability Evaluation; D018450:Disease Progression; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data*; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors