[Improved osseointegration of titanium implants after surface coating with polymers in a rabbit model].
In this study we present the first results of the investigation of polymer-coated titanium implants implanted in the proximal tibia and distal femora of New Zealand white rabbits. The results of DEXA scans, micro-CT, and histological analysis showed an increase of osseointegration. We suggest that controlled release kinetics after coupling of these polymers with BMP-2 can additionally increase osseointegration.
Thorey
F
F
Orthopädische Klinik II im Annastift, Medizinische Hochschule, Hannover. thorey@annastift.de
Witte
F
F
Nellesen
J
J
Griep-Raming
N
N
Menzel
H
H
Gross
G
G
Hoffmann
A
A
Seufert
J
J
Windhagen
H
H
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D005269:Femur / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D008422:Materials Testing; D016348:Osseointegration / Q000187:drug effects*; D010865:Pilot Projects; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D016212:Transforming Growth Factor beta / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D016212:Transforming Growth Factor beta; D014025:Titanium