title: Comparative study of enema retention and preference in ulcerative colitis.
abstract: BACKGROUND
  Therapeutic enemas are often used to treat active colitis but their retention may be limited because of urgency to defecate. Some preparations may be better retained and tolerated than others because of their physical properties.
  
  
  OBJECTIVE
  To compare patient preference and retention of four therapeutic enemas, including a nicotine enema, in patients with ulcerative colitis (UC).
  
  
  METHODS
  Twenty four patients with active UC received the four trial enemas-corticosteroid, 5-amino salicylate (5-ASA), and nicotine liquid enemas and a corticosteroid foam, in a randomised order, taking one enema on each of four successive nights. Patients scored them 1 to 4 for ease of administration and retention, degree of abdominal bloating, and for their overall preference.
  
  
  RESULTS
  Fifteen patients rated nicotine their overall favourite or second favourite, compared with 14 for corticosteroid foam and 11 for 5-ASA and corticosteroid liquids, but this was not significant (p = 0.302). Overall, there was no significant difference in overnight retention. However, the nicotine enema tended to be less well retained in patients with milder urgency but a higher proportion retained it overnight with more severe urgency (p = 0.031 compared with 5-ASA enema).
  
  
  CONCLUSIONS
  There was no significant difference in patient preference or overall duration of retention for the four enemas.
authors.affiliation: Department of Gastroenterology, Cardiff and Vale NHS Trust, Cardiff, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Ingram
authors.forename: J
authors.initials: J
authors.lastname: Rhodes
authors.forename: B K
authors.initials: BK
authors.lastname: Evans
authors.forename: R G
authors.initials: RG
authors.lastname: Newcombe
authors.forename: G A O
authors.initials: GA
authors.lastname: Thomas
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003093:Colitis, Ulcerative / Q000628:therapy*; D004733:Enema / Q000379:methods* / Q000523:psychology / Q000592:standards; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000627:therapeutic use; D017060:Patient Satisfaction
chemical_list: D000305:Adrenal Cortex Hormones; D005765:Gastrointestinal Agents; D009538:Nicotine