[Effect of ulinastatin on lung injury after dilute hydrochloric acid aspiration].
OBJECTIVE
To determine the effect of ulinastatin (UTI) on blocking the development of acute lung injury (ALI) induced by acid aspiration in the early period.


METHODS
The SD rats were randomly divided into 3 groups: control group (n = 10), injury group (n = 10), and UTI-treated group (n = 10). The rats in the control group were injected intrabronchialy saline while the other 2 groups were injected HCl. The UTI-treated group was injected UTI at 4 x 10(4) U/kg after acid instillation. Blood gas as well as wet/dry weight ratio (W/D) of the left lung was measured. The changes of IL-8 and TNF-alpha levels in the pulmonary tissues were determined by enzyme-linked immunosorbent assay.


RESULTS
The result of blood gas analysis in the UTI-treated group was much better than that in the injury group (P < 0.01). W/ D and IL-8, TNF-alpha levels were lower in the UTI-treated group than those in the injury group significantly (P < 0. 01), and there was no difference between the UTI-treated group and the control group in IL-8 and TNF-alpha levels (P > 0. 05).


CONCLUSIONS
UTI administration can lessen the development of ALI induced by acid aspiration in the early period.
Wang
Rui-Ke
RK
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhao
Shuang-Ping
SP
Yang
Xin-Ping
XP
Cai
Hong-Wei
HW
D000818:Animals; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D006851:Hydrochloric Acid; D008168:Lung / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin; D006851:Hydrochloric Acid