ATM promoter analysis in childhood lymphoid malignancies: a brief communication.
ATM promoter hypermethylation has been recently reported in adult carcinomas, but no information is available concerning the methylation status of ATM gene promoter in childhood B-precursor acute lymphoblastic leukaemia (ALL). Furthermore, involvement of somatic ATM promoter mutations in cancer is not known. We report a complete ATM gene promoter analysis in 74 childhood lymphoid malignancies.
Gumy-Pause
Fabienne
F
Department of Pediatrics, Unit of Hematology/Oncology, University Hospital of Geneva, Switzerland. fabienne.gumypause@medecine.unige.ch
Wacker
Pierre
P
Maillet
Philippe
P
Betts
David R
DR
Sappino
André-Pascal
AP
D000328:Adult; D064007:Ataxia Telangiectasia Mutated Proteins; D002051:Burkitt Lymphoma / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D017354:Point Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017422:Sequence Analysis, DNA; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases