[Apoptosis in oocyte].
Apoptosis has been reported in oocyte and preimplantation embryo. The developmental potential of embryo could be related to its rate of apoptosis. This apoptotic fate could be modulated by suboptimal culture conditions: however, a critical role is played by gamete quality and in particular, oocyte apoptosis. Thus, the investigation of apoptosis-related genes and mechanisms in oocyte is crucial. New technologies, such as microarrays, may contribute to the elucidation of molecular pathways involved in oocyte survival and maturation. Besides in vitro culture and ART, the study of oocyte apoptosis could benefit to research in the fields of menopause or cancer treatment.
Lévy
R
R
Laboratoire de biologie de la reproduction, hôpital Nord, CHU de Saint-Etienne, 42055 Saint-Etienne, France. Rachel.Levy@chu-st-etienne.fr
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D005786:Gene Expression Regulation; D006801:Humans; D009865:Oocytes / Q000502:physiology