Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue.
Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, and catechol.
Nakanishi
Ikuo
I
Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba, 263-8555, Japan. nakanis@nirs.go.jp
Nishizawa
Chiho
C
Ohkubo
Kei
K
Takeshita
Keizo
K
Suzuki
Kazuo T
KT
Ozawa
Toshihiko
T
Hecht
Sidney M
SM
Tanno
Masayuki
M
Sueyoshi
Shoko
S
Miyata
Naoki
N
Okuda
Haruhiro
H
Fukuzumi
Shunichi
S
Ikota
Nobuo
N
Fukuhara
Kiyoshi
K