title: Ketamine anaesthesia following premedication of rabbits with vitamin C.
abstract: The effects of vitamin C on ketamine anesthesia was studied. In normal rabbits the onset and duration of ketamine induced anesthesia were 6.0 +/- 0.5 and 36.0 +/- 0.9 min, respectively. Pre-treatment of rabbits with 30, 60 and 240 mg/kg, i.m. of vitamin C followed by ketamine 40 mg/ kg i.m. resulted in significant (p < 0.05) decrease in the onset and increase in duration of ketamine anesthesia to 5.0 +/- 0.06 and 37.0 +/- 0.7; 4.0 +/- 0.5 and 39.0 +/- 0.6; 2.0 +/- 2.3 and 44.0 +/- 0.8 min, respectively. There was also significant (p < 0.05) decrease in the heart rates in the animals treated with vitamin C and ketamine combinations. Serum analysis showed a significant (p < 0.05) increase in blood glucose. The observed decreased in serum calcium and phosphorous following ketamine injection was prevented by pretreatment with vitamin C. These results suggest that vitamin C at higher doses could potentiate ketamine anesthesia in rabbits.
authors.affiliation: Department of Veterinary Medicine and Surgery, Usmanu Danfodiyo University, Sokoto, Nigeria. atelsa2002@yahoo.com
authors.forename: Abdullahi
authors.initials: A
authors.lastname: Elsa
authors.forename: Stephen
authors.initials: S
authors.lastname: Ubandawaki
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000768:Anesthesia, General / Q000662:veterinary*; D000778:Anesthetics, Dissociative; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001639:Bicarbonates / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine; D008297:Male; D010100:Oxygen / Q000097:blood; D011292:Premedication / Q000662:veterinary*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
chemical_list: D000778:Anesthetics, Dissociative; D001639:Bicarbonates; D001786:Blood Glucose; D007649:Ketamine; D001205:Ascorbic Acid; D010100:Oxygen; D002118:Calcium