title: Grandparent donors in paediatric renal transplantation.
abstract: The outcome of transplantation from grandparent donors in comparison with parental donors in paediatric renal transplantation was evaluated in 53 living related donor (LRD) transplantations performed between January 1996 and August 2003. The donor in 13 cases (25%) was a grandparent (Gpar group), and the remaining donors formed the parent group (Par group). The median age of recipients in the Gpar group was 2.75 (1.7-10.6) years and in the Par group was 12.75 (2.4-22) years (P<0.0001). There was no evidence of a difference in patient and graft survival, glomerular filtration rate (GFR) after transplantation, or the number of biopsy proven episodes of rejection between the groups. Doses of prednisolone in the first year following transplantation were greater in recipients from Gpar donors, but the other immunosuppression doses were similar. The median age of donors in the Gpar group was 56 (50-67) years and in the Par group was 41 (27-58) years (P<0.0001). There was no evidence of a difference between the two donor groups in mean creatinine clearance at last follow-up. There were two major donor complications in the Gpar group and one in the Par group. There was no evidence that the length of stay differed between the two groups in either the donors or recipients. These results support the use of carefully selected healthy grandparents as LRDs in children. This option potentially allows for the use of parent donors for a subsequent transplantation.
authors.affiliation: Department of Nephrology, The Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia. kate.simpson@mcri.edu.au
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Simpson
authors.forename: Steven J
authors.initials: SJ
authors.lastname: McTaggart
authors.forename: Jonathan A C
authors.initials: JA
authors.lastname: Sterne
authors.forename: Rowan G
authors.initials: RG
authors.lastname: Walker
authors.forename: Harley R
authors.initials: HR
authors.lastname: Powell
authors.forename: Colin L
authors.initials: CL
authors.lastname: Jones
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D005190:Family; D005919:Glomerular Filtration Rate; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016030:Kidney Transplantation; D019520:Living Donors; D008875:Middle Aged
chemical_list: D007166:Immunosuppressive Agents