title: [Nontraumatic ethmoid cerebrospinal fluid rhinorrhea complicating Sheehan syndrome].
abstract: BACKGROUND
  Treatment of pituitary macroadenoma frequently leads to nontraumatic cerebrospinal fistula and rhinorrhea. We report an unusual case of rhinorrhea in a woman with Sheehan's syndrome.
  
  
  METHODS
  A 39-year-old woman receiving hormone replacement therapy for hypothyroidism diagnosed 13 years earlier (Sheehan's syndrome) developed metabolic syndrome, which combining obesity, type 2 diabetes, hypertension and mixed hyperlipidemia. Cerebrospinal fluid rhinorrhea was confirmed by measurement of the glucose concentration in her nasal discharge and by cerebral MRI, which revealed a fistula of the ethmoid bone and an empty sella. Etiological screening was negative, and normal bone densitometry as well as the absence of trauma ruled out any bone defects. Conversely, the metabolic syndrome, notably obesity, suggested a nontraumatic mechanism for the empty sella.
  
  
  CONCLUSIONS
  Onset of empty sella syndrome during treatment for Sheehan's syndrome may be the cause of the CSF rhinorrhea. The role of obesity requires further investigation.
authors.affiliation: Service d'endocrinologie-diabétologie, CHU Farhat Hached, Sousse, Tunisie. achkoussay@topnet.tn
authors.forename: K
authors.initials: K
authors.lastname: Ach
authors.forename: Y-N
authors.initials: YN
authors.lastname: Dallel
authors.forename: I
authors.initials: I
authors.lastname: Bellara
authors.forename: A-S
authors.initials: AS
authors.lastname: Trimech
authors.forename: B-A
authors.initials: BA
authors.lastname: Maaroufi
authors.forename: C-M
authors.initials: CM
authors.lastname: Chaieb
authors.forename: L
authors.initials: L
authors.lastname: Chaieb
mesh_terms: D000328:Adult; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology*; D004652:Empty Sella Syndrome / Q000150:complications* / Q000209:etiology*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D007037:Hypothyroidism / Q000188:drug therapy; D024821:Metabolic Syndrome / Q000209:etiology; D009765:Obesity / Q000150:complications