Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers.
Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.
Mecke
Almut
A
Department of Physics, The University of Michigan, Ann Arbor, Michigan 48109, USA.
Lee
Dong-Kuk
DK
Ramamoorthy
Ayyalusamy
A
Orr
Bradford G
BG
Holl
Mark M Banaszak
MM
D023181:Antimicrobial Cationic Peptides / Q000737:chemistry; D050091:Dendrimers; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D000071228:Polyelectrolytes; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
D023181:Antimicrobial Cationic Peptides; D050091:Dendrimers; D004134:Dimyristoylphosphatidylcholine; D008051:Lipid Bilayers; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers; C104700:PAMAM Starburst; C093828:pexiganan