title: Relationship between renal artery stenosis and intrarenal damage in autopsy subjects with stroke.
abstract: BACKGROUND
  In patients with cardiovascular disease (CVD), renal dysfunction is a risk factor for the prognosis, but substantial evidence is still lacking about the relationship between clinical characteristics and renal histology. The aim of our study was to evaluate the relationship between the extent of renal parenchymal damage, renal artery stenosis (RAS) and clinical characteristics in autopsy subjects with stroke.
  
  
  METHODS
  During the 17-year period 1980-1997, 2167 subjects were autopsied at the National Cardiovascular Center. We studied retrospectively all the autopsy cases aged 40 years and older who had a history of stroke. Thus, 346 subjects remained and they were classified into two groups. Thirty-six subjects had RAS (group A). Three hundred and ten subjects had no RAS, and we randomly chose 102 subjects among them (group B). We evaluated renal parenchymal damage using a semi-quantitative chronic damage score.
  
  
  RESULTS
  The average overall chronic damage score was significantly higher in the stenosed kidneys of group A than in the non-stenosed kidneys of group B (9.0+/-2.6 vs 7.0+/-2.7). The contralateral kidneys of group A had a tendency to have milder renal damage than stenosed kidneys. Furthermore, the total score was higher in the subjects with hypertension, diabetes mellitus, proteinuria, renal insufficiency and CVD than in the subjects without such complications. The total score had a significant association with RAS, proteinuria, renal insufficiency, CVD and weight of the kidney.
  
  
  CONCLUSIONS
  In autopsy subjects with stroke, we demonstrated that co-existing renal parenchymal damage was more severe in the subjects with RAS, hypertension, diabetes mellitus, proteinuria and renal insufficiency than those without such complications. The presence of RAS, impaired renal function and proteinuria was closely correlated with the severity of renal parenchymal damage.
authors.affiliation: Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Setsuko
authors.initials: S
authors.lastname: Kuroda
authors.forename: Fumiki
authors.initials: F
authors.lastname: Yoshihara
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakahama
authors.forename: Takashi
authors.initials: T
authors.lastname: Inenaga
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ueda-Ishibashi
authors.forename: Chikao
authors.initials: C
authors.lastname: Yutani
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kawano
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000453:epidemiology / Q000473:pathology; D001344:Autopsy; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011336:Probability; D012042:Registries; D012078:Renal Artery Obstruction / Q000453:epidemiology* / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology* / Q000473:pathology*