Comparative efficacy of two single-dose bacterins in the control of Mycoplasma hyopneumoniae in swine raised under commercial conditions in Brazil.
A field study was conducted in Brazil to evaluate the efficacy of single vaccination of pigs with two bacterins to prevent Mycoplasma hyopneumoniae lung lesions. The first (T1) treatment group (174 pigs) was injected with 2 mL of saline solution; group T2 (177 pigs) with 2 mL of bacterin A, and group T3 (174 pigs) with 2 mL of bacterin B. On days-on-test (DOT) 0, 35, 66, 97 and 125, blood samples and tonsil swabs were collected from selected pigs for antibody determination (indirect ELISA) and PCR assay for the presence of M. hyopneumoniae. Pigs were slaughtered on DOT 126-129 and lung lesions were scored blindly. Bacterin A vaccinated pigs had significantly (P < or = 0.05) lower lung lesion scores (0.2%) than bacterin B (0.4%) or saline-treated pigs (1.2%); there was also a significantly lower (P < or = 0.05) number of pigs with lung lesions (27.1%), than bacterin B (38.2%) or saline-treated (55.4%) pigs. The two vaccines had similar (P>0.05) results in terms of mean weight gain, average daily weight gain, feed efficiency, frequency of PCR positives, and there was similar antibody conversion (ELISA). It was concluded that although the productivity parameters and antibody conversions were similar, bacterin A was more effective in preventing and reducing the severity of lung lesions than bacterin B.
Baccaro
Maria Regina
MR
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, Av Dr Orlando Marques de Paiva, n 87, CEP 05508-000, São Paulo, SP, Brazil.
Hirose
Flavio
F
Umehara
Ossamuro
O
Gonçalves
Lineu C B
LC
Doto
Daniela Sabatini
DS
Paixão
Renata
R
Shinya
Luciane Tieko
LT
Moreno
Andrea Micke
AM
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D001938:Brazil; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D045705:Mycoplasma hyopneumoniae / Q000235:genetics / Q000276:immunology*; D045729:Pneumonia of Swine, Mycoplasmal / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013552:Swine; D014611:Vaccination / Q000662:veterinary
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004269:DNA, Bacterial