Relationship between leukocyte count and angiographical characteristics of coronary atherosclerosis.
OBJECTIVE
To explore the relationship between differential leucocyte count and coronary atherosclerosis.


METHODS
The study population consisted of 507 consecutive patients (376 male and 131 female) who underwent coronary angiography for suspected or known coronary atherosclerosis. The patients' smoking and drinking habits were investigated, and anthropometric measurements, serum measurements, and hematological measurements were conducted for every patient. The severity of coronary atherosclerosis was defined by using Gensini's score system. One-way ANOVA, Spearman's correlation analysis, and multivariate stepwise linear regression analysis were employed to explore the relationship between differential leucocyte count and coronary atherosclerosis.


RESULTS
One-way ANOVA indicated that the diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and platelet count differed among the groups according to Gensini's score, the tertile values of which were used as cutoff points. Spearman's correlation analysis suggested that Gensini's score was significantly correlated with age, diastolic blood pressure, glucose, urea, creatinine, leukocyte count, neutrophil count, monocyte count, hemoglobin, and erythrocyte count, respectively. Multivariate stepwise linear regression analysis show that neutrophil count (beta=0.247, P=0.000), age (beta=0.141, P=0.001), glucose (beta=0.173, P=0.000), creatinine (beta=0.088, P=0.063), hemoglobin (beta=-0.168, P=0.013) and sex (men were coded as 1 and women were coded as 2; beta=-0.121, P=0.012) were significantly independently associated with the Gensini's score.


CONCLUSIONS
The independent association of neutrophil count with the angiographical characteristics of coronary atherosclerosis, as estimated by Gensini's score, strongly suggests that granulocytosis may play a role in the development of coronary atherosclerosis.
Jia
En-zhi
EZ
Department of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. enzhijia@yahoo.com.cn
Yang
Zhi-jian
ZJ
Yuan
Biao
B
Zang
Xiao-ling
XL
Wang
Rong-hu
RH
Zhu
Tie-bing
TB
Wang
Lian-sheng
LS
Chen
Bo
B
Ma
Wen-zhu
WZ
D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D003404:Creatinine / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000473:pathology*; D012720:Severity of Illness Index; D012737:Sex Factors; D012907:Smoking
D001786:Blood Glucose; D006454:Hemoglobins; D003404:Creatinine