Oral feeding and nasal instillation immunization with Microtus brandti lactate dehydrogenase C epitope DNA vaccine reduces fertility in mice via specific antibody responses.
The immune responses induced by Microtus brandti lactate dehydrogenase C4 DNA vaccine via oral feeding and nasal instillation in mouse were investigated. The number of newborns of the vaccinated mice was statistically significantly reduced compared with the control mice, but the vaccine failed to affect the birthrate, as all vaccinated mice gave birth.
Shi
Shu-Qun
SQ
State Key Laboratory of Reproductive Biology, Institute of Zoology, Beijing, People's Republic of China.
Wang
Jin-Ling
JL
Peng
Jing-Pian
JP
Chang
Jian-Jun
JJ
Yang
Ying
Y
D000281:Administration, Intranasal; D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D003411:Arvicolinae / Q000276:immunology*; D000939:Epitopes / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000276:immunology; D006367:HeLa Cells; D006801:Humans; D007527:Isoenzymes / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D007770:L-Lactate Dehydrogenase / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*
D000939:Epitopes; D007527:Isoenzymes; D019444:Vaccines, DNA; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4