A new, heavier-than-water silicone oil: a solution of perfluorohexyloctane in polydimethylsiloxane.
OBJECTIVE
To pre p a re and explore new solutions of semifluorinated alkane in silicone oil, which have a specific gravity slightly higher than silicone oil and vitreous fluid (referred to in the following as heavier-than-water silicone oils (HWSs), and to investigate, in vitro, whether HWSs can be used to plug retina holes, while allowing dehydration of the subretinal space.


METHODS
HWS solutions were pre p a red with silicone oil 5000 and perfluorohexyloctane (F6H8). The stability was investigated under different conditions. The viscosity was determined by means of a capillary viscometer. The surface and interface tension were measured using the ring method.


RESULTS
HWSs are insoluble in an aqueous medium. Densiron(R)68 (HWS 1.06) is a transparent homogeneous liquid which is slightly heavier (1.06 g/cm3) than water and has a refractive index close to that of vitreous liquid. Densiron68 (HWS 1.06) has a low viscosity (1480 mPas) and interface tension (40.82 mN/m), making it an effective tamponade in the surgical treatment of an inferior detached retina. In addition, the interfaces between Densiron68 and other perfluorocarbon liquids are clearly visible. However, the interface layer between Densiron68 and water is not clear. Finally, all HWSs are stable over the long term at ambient temperatures, as well as physically and thermally resistant. CONCLUSIONS. Due to its physiochemical properties, Densiron68 could meet the requirements for a heavier-than-water tamponade.
Kim
Y K
YK
Fluoron GmbH, Neu-Ulm, Germany.
Günther
B
B
Meinert
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D000328:Adult; D000818:Animals; D004129:Dimethylpolysiloxanes / Q000737:chemistry* / Q000633:toxicity; D004322:Drainage; D004338:Drug Combinations; D004355:Drug Stability; D005466:Fluorocarbons / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D007739:L Cells / Q000187:drug effects; D051379:Mice; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000633:toxicity; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D012031:Refractometry; D012827:Silicone Oils / Q000737:chemistry* / Q000633:toxicity; D012828:Silicones / Q000737:chemistry* / Q000633:toxicity; D013046:Specific Gravity; D013500:Surface Tension; D014783:Viscosity
D004129:Dimethylpolysiloxanes; D004338:Drug Combinations; D005466:Fluorocarbons; D009883:Ophthalmic Solutions; D012827:Silicone Oils; D012828:Silicones; C013830:baysilon; C118616:perfluorohexyl-octan