Mechanical responses of a compliant electrospun poly(L-lactide-co-epsilon-caprolactone) small-diameter vascular graft.
To design a "mechano-active" small-diameter artificial vascular graft, a tubular scaffold made of elastomeric poly(L-lactide-co-epsilon-caprolactone) fabrics at different wall thicknesses was fabricated using an electrospinning (ELSP) technique. The wall thickness of the fabricated tube (inner diameter; approximately 2.3-2.5 mm and wall thickness; 50-340 microm) increased proportionally with ELSP time. The wall thickness dependence of mechanical responses including intraluminal pressure-induced inflation was determined under static and dynamic flow conditions. From the compliance-related parameters (stiffness parameter and diameter compliance) measured under static condition, the smaller the wall thickness, the more compliant the tube. Under dynamic flow condition (1 Hz, maximal/minimal pressure of 90 mmHg/45 mmHg) produced by a custom-designed arterial circulatory system, strain, defined as the relative increase in diameter per pulse, increased with the decrease in wall thickness, which approached that of a native artery. Thus, a mechano-active scaffold that pulsates synchronously by responding to pulsatile flow was prepared using elastomeric PLCL as a base material and an ELSP technique.
Inoguchi
Hiroyuki
H
Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Kwon
Il Keun
IK
Inoue
Eiko
E
Takamizawa
Keiichi
K
Maehara
Yoshihiko
Y
Matsuda
Takehisa
T
D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology / Q000637:transplantation / Q000648:ultrastructure; D001013:Aorta, Thoracic / Q000502:physiology / Q000637:transplantation / Q000648:ultrastructure; D001672:Biocompatible Materials; D001783:Blood Flow Velocity / Q000502:physiology; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation; D003187:Compliance; D008422:Materials Testing / Q000295:instrumentation; D011091:Polyesters; D011817:Rabbits
D001672:Biocompatible Materials; D011091:Polyesters; C062968:lactide-caprolactone copolymer