title: [Paradoxical worsening of cavernous sinus dural arteriovenous fistula: case report with serial angiograms].
abstract: We report, with serial angiograms, a case worsening of dural arteriovenous fistulae (DAVFs) located at the hypoplastic right cavernous sinus and draining into the left superior ophthalmic vein across the inter-cavernous sinus. The patient presented with sudden onset of external ophthalmoplegia and deterioration of visual acuity on the left. An imaging work-up at the day of admission included contrast-enhanced computed tomography and conventional catheter angiography, which demonstrated complete thrombosis of the left cavernous sinus. There was no strong evidence to suggest DAVFs other than small faint opacification of the posterior cavernous sinus on the right at the late arterial phase. For this reason a diagnosis of left cavernous sinus thrombosis was made, followed by aggressive anticoagulation therapy with intravenous administration of antibiotics. Although the patient's eye symptoms improved significantly after the anticoagulation therapy, the follow-up angiogram obtained 5 days after admission demonstrated small right cavernous sinus DAVFs, which drained into the left superior ophthalmic vein. The patient was followed up conservatively at the out-patient clinic. Three-month follow up angiograms demonstrated spontaneous cure of the DAVF. Also noted was a complete recovery of external ophthalmoplegia with significant improvement of left visual acuity. The alternation of clinical and angiographic findings in this case may help to understand the etiology of paradoxical worsening of cavernous sinus DAVF. In selected cases, anticoagulation therapy may help to improve the prognosis of paradoxical worsening.
authors.affiliation: Neurological Surgery Service, Atsugi Municipal Hospital, 1-16-36 Mizuhiki, Atsugi-shi, Kanagawa 243-0004, Japan. stateshi@ucla.edu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tateshima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Akiyama
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Abe
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001164:Arteriovenous Fistula / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002426:Cavernous Sinus; D002533:Cerebral Angiography; D004388:Dura Mater / Q000098:blood supply*; D005260:Female; D006801:Humans; D009886:Ophthalmoplegia / Q000209:etiology; D013927:Thrombosis / Q000150:complications
chemical_list: D000925:Anticoagulants