Nephroscreen: a diagnostic test for predicting acute renal failure?
Acute renal failure is a frequent and often fatal complication of hospitalized patients. While the risk of acute renal failure among select patient groups is well recognized, physicians currently rely on diagnostic tests such as changes of serum creatinine and indirect assessment of the glomerular filtration rate to diagnose acute renal failure. Although these parameters capture the degree of kidney function lost, they are not warning signs of evolving kidney injury. While the clinical emergence of acute renal failure is sudden, the pathologic changes preceding loss of kidney function are not so sudden. Nephroscreen is a fast and easy-to-use urine enzyme-linked immunosorbent assay test designed to quantify specific pathologic events preceding death of renal proximal tubule cells. It detects acute kidney damage days before serum creatinine rises and may open new avenues to defining acute renal failure as well as treating acute renal failure patients earlier and more effectively.
Howard
Marion A
MA
Cambridge Biostrategies, LLC, PO Box 400971, Cambridge MA 02140, USA. mah@cambridgebiostrategies.com
D058186:Acute Kidney Injury / Q000175:diagnosis*; D000818:Animals; D015415:Biomarkers; D003955:Diagnostic Tests, Routine / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000473:pathology
D015415:Biomarkers