title: Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.
abstract: The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
authors.affiliation: Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rosas@helix.mgh.harvard.edu
authors.forename: H D
authors.initials: HD
authors.lastname: Rosas
authors.forename: N D
authors.initials: ND
authors.lastname: Hevelone
authors.forename: A K
authors.initials: AK
authors.lastname: Zaleta
authors.forename: D N
authors.initials: DN
authors.lastname: Greve
authors.forename: D H
authors.initials: DH
authors.lastname: Salat
authors.forename: B
authors.initials: B
authors.lastname: Fischl
mesh_terms: D000328:Adult; D001284:Atrophy / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology; D003342:Corpus Striatum / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005260:Female; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D009483:Neuropsychological Tests; D009687:Nuclear Proteins / Q000235:genetics; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins