title: A global view of atherothrombosis: baseline characteristics in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial.
abstract: BACKGROUND
  The manifestations of atherothrombosis such as myocardial infarction, ischemic stroke, limb ischemia, or cardiovascular death pose a global health care burden. Additional therapies to decrease ischemic events in patients with established vascular disease or at risk for developing vascular disease are necessary. We sought to characterize the risk factors and treatments of a diverse contemporary population of patients with atherothrombosis.
  
  
  METHODS
  The CHARISMA trial has enrolled 15,603 patients from around the world. Patients with established coronary, cerebrovascular, or peripheral arterial disease, or those at high risk of developing atherothrombosis due to multiple risk factors, have been randomized to receive either the adenosine diphosphate receptor antagonist clopidogrel or placebo, in addition to background therapy with low- to moderate-dose aspirin.
  
  
  RESULTS
  A high percentage of enrolled patients are being treated with statins and angiotensin-converting enzyme inhibitors. In the CHARISMA population, a total of 75.6% of the population had an abnormal body mass index: 42.2% were overweight and 33.4% were obese, with particularly high rates in the United States, especially of morbid obesity. Correspondingly, the prevalence of diabetes was 42%.
  
  
  CONCLUSIONS
  The CHARISMA trial will further characterize atherothrombosis and provide insight into the role of dual antiplatelet therapy in improving outcomes in patients with multiple risk factors or established vascular disease. Of note, the rates of obesity and diabetes in patients with atherothrombosis throughout the world are particularly alarming.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. bhattd@ccf.org
authors.forename: Deepak L
authors.initials: DL
authors.lastname: Bhatt
authors.forename: Keith A
authors.initials: KA
authors.lastname: Fox
authors.forename: Werner
authors.initials: W
authors.lastname: Hacke
authors.forename: Peter B
authors.initials: PB
authors.lastname: Berger
authors.forename: Henry R
authors.initials: HR
authors.lastname: Black
authors.forename: William E
authors.initials: WE
authors.lastname: Boden
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.forename: Eric A
authors.initials: EA
authors.lastname: Cohen
authors.forename: Mark A
authors.initials: MA
authors.lastname: Creager
authors.forename: J Donald
authors.initials: JD
authors.lastname: Easton
authors.forename: Marcus D
authors.initials: MD
authors.lastname: Flather
authors.forename: Steven M
authors.initials: SM
authors.lastname: Haffner
authors.forename: Christian W
authors.initials: CW
authors.lastname: Hamm
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Hankey
authors.forename: S Claiborne
authors.initials: SC
authors.lastname: Johnston
authors.forename: Koon-Hou
authors.initials: KH
authors.lastname: Mak
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mas
authors.forename: Gilles
authors.initials: G
authors.lastname: Montalescot
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Pearson
authors.forename: P Gabriel
authors.initials: PG
authors.lastname: Steg
authors.forename: Steven R
authors.initials: SR
authors.lastname: Steinhubl
authors.forename: Michael A
authors.initials: MA
authors.lastname: Weber
authors.forename: Joan
authors.initials: J
authors.lastname: Booth
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Topol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D000077144:Clopidogrel; D003327:Coronary Disease / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000517:prevention & control*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control*; D012307:Risk Factors; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000077144:Clopidogrel; D013988:Ticlopidine