title: Pathophysiological manifestations in mice exposed to anthrax lethal toxin.
abstract: Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.
authors.affiliation: Lab Animal Resources, University of Kansas Medical Center, Kansas City, 66160, USA. nculley@kumc.edu
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Culley
authors.forename: David M
authors.initials: DM
authors.lastname: Pinson
authors.forename: Anuradha
authors.initials: A
authors.lastname: Chakrabarty
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Mayo
authors.forename: Steven M
authors.initials: SM
authors.lastname: LeVine
mesh_terms: D000818:Animals; D000881:Anthrax / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D000942:Antigens, Bacterial / Q000633:toxicity*; D001427:Bacterial Toxins / Q000633:toxicity*; D001808:Blood Vessels / Q000503:physiopathology; D001980:Bronchi / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000382:microbiology* / Q000503:physiopathology; D005340:Fibrinogen / Q000032:analysis; D006470:Hemorrhage / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009206:Myocardium / Q000737:chemistry / Q000473:pathology
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin; D005340:Fibrinogen