IRF-3 releases its inhibitions.
Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.
Hiscott
John
J
Lin
Rongtuan
R
D000818:Animals; D050882:CREB-Binding Protein / Q000737:chemistry*; D050838:Interferon Regulatory Factor-3 / Q000737:chemistry*; D011487:Protein Conformation
D050838:Interferon Regulatory Factor-3; D050882:CREB-Binding Protein