Screening the SPO11 and EIF5A2 genes in a population of infertile men.
Populations of infertile and fertile men were screened for mutations in SPO11 and EIF5A2, two infertility candidate genes. Three heterozygous amino acid changes that might contribute to infertility were identified in the infertile group.
Christensen
Greg L
GL
University of Utah School of Medicine, Salt Lake City, Utah, USA.
Ivanov
Ivaylo P
IP
Atkins
John F
JF
Mielnik
Anna
A
Schlegel
Peter N
PN
Carrell
Douglas T
DT
D004706:Endodeoxyribonucleases; D004950:Esterases / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009154:Mutation; D010448:Peptide Initiation Factors / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D000097574:Eukaryotic Translation Initiation Factor 5A; D000099257:Meiotic Recombination Protein SPO11
D004706:Endodeoxyribonucleases; D004950:Esterases; D010448:Peptide Initiation Factors; D016601:RNA-Binding Proteins; D000097574:Eukaryotic Translation Initiation Factor 5A; D000099257:Meiotic Recombination Protein SPO11