Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier.
Tröger
Uwe
U
Institute of Clinical Pharmacology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany. uwe.troeger@medizin.uni-magdeburg.de
Lins
Hartmut
H
Scherrmann
Jean-M
JM
Wallesch
Claus-Werner
CW
Bode-Böger
Stefanie M
SM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000187:drug effects*; D003078:Colchicine / Q000009:adverse effects* / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D011782:Quadriplegia / Q000139:chemically induced*; D014700:Verapamil / Q000009:adverse effects*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014700:Verapamil; D003078:Colchicine