title: Results of radiotherapy for Peyronie's disease.
abstract: OBJECTIVE
  To retrospectively review the results of radiotherapy for Peyronie's disease.
  
  
  METHODS
  In the time interval 1983-2000, 154 patients in our clinic were irradiated for Peyronie's disease. Of those, 101 had at least one complete follow-up data set and are the subject of this study. In the majority of patients, penis deviation was between 30 and 50 degrees , there were one or two indurated foci with a diameter between 5 and 15 mm. Pain was recorded in 48/92 patients. Seventy-two of the 101 patients received radiotherapy with a total dose of 30 Gy, and 25 received 36 Gy in daily fractions of 2.0 Gy. The remaining patients received the following dosage: 34 Gy (1 patient), 38-40 Gy (3 patients). Mean duration of follow-up was 5 years.
  
  
  RESULTS
  The best results ever at any time during follow-up were an improvement of deviation in 47%, reduction of number of foci in 32%, reduction of size of foci in 49%, and less induration in 52%. Approximately 50% reported pain relief after radiotherapy. There were 28 patients with mild acute dermatitis and only 4 patients with mild urethritis. There were no long-term side effects.
  
  
  CONCLUSIONS
  Our results compare well with those of other studies in the literature. In our patient cohort, radiotherapy was an effective therapy option with only very rare and mild side effects.
authors.affiliation: Clinic for Radiooncology, The Saarland University Hospital, Homburg, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Niewald
authors.forename: Knut V
authors.initials: KV
authors.lastname: Wenzlawowicz
authors.forename: Jochen
authors.initials: J
authors.lastname: Fleckenstein
authors.forename: Lothar
authors.initials: L
authors.lastname: Wisser
authors.forename: Harry
authors.initials: H
authors.lastname: Derouet
authors.forename: Christian
authors.initials: C
authors.lastname: Rübe
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome