title: Scleroderma with type III glomerulonephritis and MPO-ANCA antibodies in the serum.
abstract: Scleroderma is an autoimmune disease characterized by early inflammatory infiltrates followed by fibrosis in the skin and internal organs. CREST is a relatively benign cutaneous variant of scleroderma that features calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectases. Glomerulonephritis is a rare association of CREST. We are reporting a patient with CREST who developed glomerulonephritis and had anticentromere and antineutrophil cytoplasmic autoantibodies (ANCA) in her serum.
authors.affiliation: Department of Immunology, Centro de Biología Experimental, Universidad Autónoma de Zacatecas, and Department of Internal Medicine, HGZ1 IMSS, Zacatecas, México. herreraavalos@prodigy.net.mx
authors.forename: R
authors.initials: R
authors.lastname: Herrera-Esparza
authors.forename: J-L
authors.initials: JL
authors.lastname: Aguilar
authors.forename: A
authors.initials: A
authors.lastname: Saucedo
authors.forename: I
authors.initials: I
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: López-Robles
authors.forename: E
authors.initials: E
authors.lastname: Avalos-Díaz
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis / Q000276:immunology*; D001707:Biopsy, Needle; D017675:CREST Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis / Q000276:immunology; D018570:Risk Assessment; D012595:Scleroderma, Systemic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D003520:Cyclophosphamide; D009195:Peroxidase; D008775:Methylprednisolone