Neopetrosiamides, peptides from the marine sponge Neopetrosia sp. that inhibit amoeboid invasion by human tumor cells.
[structure: see text] Neopetrosiamdes A (1) and B (2), two diastereomeric tricyclic peptides that inhibit amoeboid invasion of human tumor cells, have been isolated from the marine sponge Neopetrosia sp. collected in Papua New Guinea. The structures of the neopetrosiamides were elucidated by analysis of MS and NMR data and confirmed by chemical degradation.
Williams
David E
DE
Department of Chemistry, Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
Austin
Pamela
P
Diaz-Marrero
Ana R
AR
Soest
Rob Van
RV
Matainaho
Teatulohi
T
Roskelley
Calvin D
CD
Roberge
Michel
M
Andersen
Raymond J
RJ
D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D012451:Safrole / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
D010455:Peptides; D010456:Peptides, Cyclic; C512184:neopetrosiamide A; C512185:neopetrosiamide B; D008715:Methionine; D012451:Safrole; C005746:sulfoxide; C013111:methionine sulfoxide