Can platelet function tests predict the clinical efficacy of aspirin?
"Aspirin resistance" and "aspirin nonresponsiveness" are terms used both to describe both the failure of aspirin to protect subgroups of individuals from severe vascular events and to evoke an appropriate inhibition of platelet function. Several studies utilizing a broad range of platelet function tests have shown that some subgroups of individuals exhibit a reduced or completely missing antiplatelet response to aspirin. The clinical significance of aspirin nonresponsiveness for the prediction of clinical endpoints remains, however, to be determined. Thus far, only three prospective clinical trials have demonstrated a possible relationship between aspirin nonresponsiveness and subsequent vascular events. Most platelet function tests used in respective clinical studies cannot be reliably performed in clinical routine and are not interchangeable for monitoring antiplatelet treatment. There is a need for a simple and reliable assay for predicting the clinical efficacy of antiplatelet therapy. Recent data demonstrate that none of the currently developed assays, including the PFA-100 system, are presently able to accomplish these objectives.
Haubelt
Hannelore
H
Institute of Hemostaseology and Transfusion Medicine, Academic City Hospital, Ludwigshafen, Germany.
Anders
Christof
C
Hellstern
Peter
P
D000244:Adenosine Diphosphate / Q000737:chemistry; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D002986:Clinical Trials as Topic; D004351:Drug Resistance; D005434:Flow Cytometry; D006801:Humans; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests / Q000379:methods*; D011237:Predictive Value of Tests; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D000244:Adenosine Diphosphate; C049235:11-dehydro-thromboxane B2; D001241:Aspirin