Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus.
Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.
López-Gresa
M Pilar
MP
Centro de Ecologia Química Agrícola, Universidad Politécnica de Valencia, Campus de Vera, Edificio 9B, Laboratorio 111, Valencia, Spain. mplopez@ceqa.upv.es
González
M Carmen
MC
Primo
Jaime
J
Moya
Pilar
P
Romero
Vanessa
V
Estornell
Ernesto
E
D001235:Aspergillus ochraceus / Q000378:metabolism*; D001570:Benzodiazepinones / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004579:Electron Transport / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D001570:Benzodiazepinones; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; C504253:circumdatin H; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases