title: Effects of donepezil on compulsive hypersexual behavior in Parkinson disease: a single case study.
abstract: Hypersexuality is a known, though not frequently publicized, behavioral disturbance in patients with Parkinson disease. Hypersexuality has been associated with dopaminergic drug therapy. We describe a patient with Parkinson disease who presented with compulsive hypersexual behavior. Lowering of dopaminergic drug doses was of minimal behavioral benefit but was not well tolerated because of worsening of motor function. A trial with donepezil led to significant amelioration of the compulsive behavior without adverse motor effects.
authors.affiliation: Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Larry S
authors.initials: LS
authors.lastname: Ivanco
authors.forename: Nicolaas I
authors.initials: NI
authors.lastname: Bohnen
mesh_terms: D000547:Amantadine / Q000009:adverse effects; D002230:Carbidopa / Q000009:adverse effects; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D000077265:Donepezil; D015259:Dopamine Agents / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D010479:Pergolide / Q000009:adverse effects; D010880:Piperidines / Q000627:therapeutic use*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D002800:Cholinesterase Inhibitors; D015259:Dopamine Agents; D007189:Indans; D010880:Piperidines; D010479:Pergolide; D007980:Levodopa; D000077265:Donepezil; D000547:Amantadine; D002230:Carbidopa