The influence of chosen metals administration in drinking water on magnesium balance in rats.
The aim of our study was to estimate the influence of chromium, lead and aluminium on the magnesium level in serum and tissues of rats. Male Wistar rats received Cr, Pb and Al at the concentration of 500 mg of metal x dm(-3) in the form of drinking water for three or six weeks. After the period of administration the animals were sacrificed under ketamine narcosis and blood from the heart as well as the tissues of the liver, kidney, brain, spleen, femoral muscle and heart muscle were collected. Magnesium concentration was measured in serum and tissue homogenates. Chromium caused the increase of Mg level in some tissues after six weeks and no changes in serum. Lead influenced Mg level in serum and tissues mainly after six weeks but the changes were more diverse and depending on the tissue. After six weeks' administration aluminium caused the magnesium release from serum and its storage in tissues.
Kiełczykowska
Małgorzata
M
Department of General Chemistry, Skubiszewski Medical University of Lublin.
Pasternak
Kazimierz
K
Boguszewska
Anna
A
Musik
Irena
I
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D002857:Chromium / Q000633:toxicity*; D007854:Lead / Q000633:toxicity*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D002857:Chromium; D007854:Lead; D000535:Aluminum; D008274:Magnesium