Role of interleukin 4 in Spanish multiple sclerosis patients.
Interleukin 4 is a Th2 cytokine with potent anti-inflammatory properties. Protection from autoimmune encephalomyelitis and multiple sclerosis has been achieved with IL-4 therapy and IL-4 deficient mice developed a more severe form of clinical disease. Four polymorphisms within the IL-4 gene are in strong linkage disequilibrium, including one in the promoter at -590, which controls transcriptional activity. An MS protective role for the heterozygous genotype was confirmed in Spain (exon-1+33 C/T: p=0.003, OR [CI]=0.57 [0.38-0.84]), probably indicative of an MS protection haplotype at 5q31 locus. No difference among MS clinical forms or age at onset was detected.
Urcelay
Elena
E
Immunology Department, Hospital Universitario San Carlos, Martin Lagos s/n, 28040 Madrid, Spain. eurcelay@hcsc.es
Santiago
Jose Luis
JL
Mas
Ana
A
Martínez
Alfonso
A
de Las Heras
Virginia
V
Arroyo
Rafael
R
de la Concha
Emilio G
EG
D000328:Adult; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013030:Spain / Q000453:epidemiology
D015847:Interleukin-4