[Non-myeloablative allogenic peripheral blood stem cell transplantation for treatment of advanced renal cell carcinoma].
Non-myeloablative allogenic peripheral blood stem cell transplantation (mini-transplant) is becoming a preferred treatment for those recipients in whom the potential toxicity risk of standard ablative allogeneic therapy may be acceptable. Graft-versus-tumor effect may be generated against epithelial malignancies that are similar to the graft-versus-leukemia activity documented in human hematological malignancies. Renal cell carcinoma has been shown to be responsive to immunotherapy with recombinant human cytokines and may be an ideal model for exploring this novel therapy. Clinical investigations have demonstrated regression of advanced renal cell carcinoma occurs in some patients following non-myeloablative allogenic peripheral blood stem cell transplantation. However, graft-versus-host disease remains a significant toxicity of nonablative transplantation, and directions for further study include the identification of the definitive tumor antigens involved in the graft-versus-tumor effect and means of selecting those patients who will benefit the most from this promising approach with due regard to improve its safety.
Konaka
Hiroyuki
H
The Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science.
Takami
Akiyoshi
A
Koshida
Kiyoshi
K
Nakao
Shinji
S
Namiki
Mikio
M
D002292:Carcinoma, Renal Cell / Q000628:therapy*; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods