title: Comparing long-term survival of patients with multivessel coronary disease after CABG or PCI: analysis of BARI-like patients in northern New England.
abstract: BACKGROUND
  Randomized trials comparing coronary artery bypass graft surgery (CABG) with percutaneous coronary interventions (PCIs) for patients with multivessel coronary disease (MVD) report similar long-term survival for CABG and PCI. These studies used a highly selected population of patients and providers, and their results may not be generalizable to actual care. Our goal in this study was to compare long-term survival of MVD patients treated with CABG vs PCI in contemporary practice.
  
  
  RESULTS
  From our northern New England registries of consecutive coronary revascularizations, we identified 10,198 CABG and 4,295 PCI patients with MVD who may have been eligible for either procedure between 1994 and 2001. Vital status was obtained by linkage to the National Death Index. Proportional-hazards regression was used to calculate hazard ratios (HRs) for survival in CABG vs PCI patients after adjustment for comorbidities and disease characteristics. CABG patients were older; had more comorbidities, more 3-vessel disease, and lower ejection fractions; and were more completely revascularized. Adjusted long-term survival for patients with 3-vessel disease was better after CABG than PCI (HR, 0.60; P<0.01) but not for patients with 2-vessel disease (HR, 0.98; P=0.77). The survival advantage of CABG for 3-vessel disease patients was present in all patient populations, including women, diabetics, and the elderly and in the era of high stent utilization.
  
  
  CONCLUSIONS
  In contemporary practice, survival for patients with 3-vessel coronary disease is better after CABG than PCI, an observation that patients and physicians should carefully consider when deciding on a revascularization strategy.
authors.affiliation: Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. David.Malenka@Hitchcock.org
authors.forename: David J
authors.initials: DJ
authors.lastname: Malenka
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Leavitt
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hearne
authors.forename: John F
authors.initials: JF
authors.lastname: Robb
authors.forename: Yvon R
authors.initials: YR
authors.lastname: Baribeau
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Ryan
authors.forename: Robert E
authors.initials: RE
authors.lastname: Helm
authors.forename: Mirle A
authors.initials: MA
authors.lastname: Kellett
authors.forename: Harold L
authors.initials: HL
authors.lastname: Dauerman
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Dacey
authors.forename: M Theodore
authors.initials: MT
authors.lastname: Silver
authors.forename: Peter N
authors.initials: PN
authors.lastname: VerLee
authors.forename: Paul W
authors.initials: PW
authors.lastname: Weldner
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hettleman
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Olmstead
authors.forename: Winthrop D
authors.initials: WD
authors.lastname: Piper
authors.forename: Gerald T
authors.initials: GT
authors.lastname: O'Connor
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000706:statistics & numerical data*; D015331:Cohort Studies; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data*; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009511:New England / Q000453:epidemiology; D016016:Proportional Hazards Models; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013318:Stroke Volume; D016019:Survival Analysis