A complex adaptive systems approach to the kinetic folding of RNA.
The kinetic folding of RNA sequences into secondary structures is modeled as a complex adaptive system, the components of which are possible RNA structural rearrangements (SRs) and their associated bases and base pairs. RNA bases and base pairs engage in local stacking interactions that determine the probabilities (or fitnesses) of possible SRs. Meanwhile, selection operates at the level of SRs; an autonomous stochastic process periodically (i.e., from one time step to another) selects a subset of possible SRs for realization based on the fitnesses of the SRs. Using examples based on selected natural and synthetic RNAs, the model is shown to reproduce characteristic (nonlinear) RNA folding dynamics such as the attainment by RNAs of alternative stable states. Possible applications of the model to the analysis of properties of fitness landscapes, and of the RNA sequence-to-structure mapping are discussed.
Ndifon
Wilfred
W
Departments of Biology and Mathematics, Morgan State University, Baltimore, MD 21251, USA. windi1@mymail.morgan.edu
D005798:Genes, Bacterial; D007700:Kinetics; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D012313:RNA / Q000737:chemistry*; D012984:Software; D013269:Stochastic Processes; D049490:Systems Biology; D013696:Temperature; D013997:Time Factors
D012313:RNA