Cocaine-induced renal infarction: report of a case and review of the literature.
BACKGROUND
Cocaine abuse has been known to have detrimental effects on the cardiovascular system. Its toxicity has been associated with myocardial ischemia, cerebrovascular accidents and mesenteric ischemia. The pathophysiology of cocaine-related renal injury is multifactorial and involves renal hemodynamic changes, alterations in glomerular matrix synthesis, degradation and oxidative stress, and possibly induction of renal atherogenesis. Renal infarction as a result of cocaine exposure, however, is rarely reported in the literature.


METHODS
A 48 year-old male presented with a four-day history of severe right flank pain following cocaine use. On presentation, he was tachycardic, febrile and had severe right costovertebral angle tenderness. He had significant proteinuria, leukocytosis and elevated serum creatinine and lactate dehydrogenase. Radiographic imaging studies as well as other screening tests for thromboembolic events, hypercoagulability states, collagen vascular diseases and lipid disorders were suggestive of Cocaine-Induced Renal Infarction (CIRI) by exclusion.


CONCLUSIONS
In a patient with a history of cocaine abuse presenting with fevers and flank pain suggestive of urinary tract infection or nephrolithiasis, cocaine-induced renal infarction must be considered in the differential diagnosis. In this article, we discuss the prior reported cases of CIRI and thoroughly review the literature available on this disorder. This is important for several reasons. First, it will allow us to discuss and elaborate on the mechanism of renal injury caused by cocaine. In addition, this review will demonstrate the importance of considering the diagnosis of CIRI in a patient with documented cocaine use and an atypical presentation of acute renal injury. Finally, we will emphasize the need for a consensus on optimal treatment of this disease, for which therapy is not yet standardized.
Bemanian
Shahrooz
S
Department of Medicine, University of Southern California, Keck School of Medicine, LAC-USC Medical Center, Los Angeles, USA. bemanian@usc.edu
Motallebi
Mazda
M
Nosrati
Saeid M
SM
D003042:Cocaine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D006801:Humans; D007238:Infarction / Q000139:chemically induced* / Q000175:diagnosis; D007668:Kidney / Q000098:blood supply*; D007669:Kidney Calculi / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014552:Urinary Tract Infections / Q000175:diagnosis
D003042:Cocaine