title: Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection.
abstract: An unusual female case, with alveolar echinococcosis (AE) disseminated from the primary hepatic lesion to the brain by metastasis formation, was retrospectively identified during a community survey in Ningxia Hui Autonomous Region, northwest China in 2003. Among possible metastases of hepatic AE, locations to the brain are rare and usually fatal; and they have especially been assigned to concomitant immune suppression. An enhancing role of pregnancy, which may be suspected in this case, the favourable outcome after surgery and chemotherapy, and also a mental disability in a child following long-term intrauterine exposure to mebendazole, make the report particularly unique.
authors.affiliation: Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Q 4006, Australia.
authors.forename: Y R
authors.initials: YR
authors.lastname: Yang
authors.forename: D A
authors.initials: DA
authors.lastname: Vuitton
authors.forename: M K
authors.initials: MK
authors.lastname: Jones
authors.forename: P S
authors.initials: PS
authors.lastname: Craig
authors.forename: D P
authors.initials: DP
authors.lastname: McManus
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000871:Anthelmintics / Q000009:adverse effects; D001927:Brain Diseases / Q000469:parasitology / Q000473:pathology*; D020808:Central Nervous System Protozoal Infections / Q000469:parasitology / Q000473:pathology*; D004443:Echinococcosis / Q000188:drug therapy / Q000473:pathology*; D004444:Echinococcosis, Hepatic / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D008463:Mebendazole / Q000009:adverse effects; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy
chemical_list: D000871:Anthelmintics; D008463:Mebendazole