title: Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations.
abstract: Glutathione S-Transferase P1 (GSTP1) is an important enzyme in the detoxification of products of oxidative stress. Several studies have shown an association of the amino acid variant Ile105Val with bronchial asthma and the reaction of the lung to inhalant pollutants. The aim of this study was to test the two known amino acid variants in GSTP1 for association with bronchial asthma and airway hyper-responsiveness in two German pediatric populations. We genotyped Ile105Val and Ala114Val in the Multicenter Allergy Study cohort (85 children with asthma, 123 controls) and asthmatic children from Freiburg (n = 178). We did not find association of either polymorphisms with bronchial asthma or airway hyper-responsiveness. We conclude from our data that polymorphisms within GSTP1 do not play a major role in the development of bronchial asthma in German children.
authors.affiliation: Department of Pediatric Pneumonology and Immunology, Charité, Humboldt University, Berlin, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Nickel
authors.forename: Assja
authors.initials: A
authors.lastname: Haider
authors.forename: Claudia
authors.initials: C
authors.lastname: Sengler
authors.forename: Susanne
authors.initials: S
authors.lastname: Lau
authors.forename: Bodo
authors.initials: B
authors.lastname: Niggemann
authors.forename: Klaus A
authors.initials: KA
authors.lastname: Deichmann
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wahn
authors.forename: Andrea
authors.initials: A
authors.lastname: Heinzmann
mesh_terms: D000293:Adolescent; D000409:Alanine; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000235:genetics* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000235:genetics; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D007532:Isoleucine; D011110:Polymorphism, Genetic; D012129:Respiratory Function Tests; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics; D014633:Valine
chemical_list: D007532:Isoleucine; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D014633:Valine; D000409:Alanine