title: beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice.
abstract: Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop in the large bowel of aged Apc(Min/+) mice. In this study, we determined the presence and location of BCAC in the large intestine of juvenile Apc(Min/+) mice (3 and 5 weeks of age). Surprisingly, BCAC were noted in the colon of even Apc(Min/+) mice of both ages, and mainly located in the distal and middle segments of the colon. Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice.
authors.affiliation: BMR Laboratories, Sunplanet Co., Ltd, 4388 Hagiwara, Kamiishidu, Yourou, Gifu 503-1602, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Hata
authors.forename: Takuji
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kohno
authors.forename: Rikako
authors.initials: R
authors.lastname: Suzuki
authors.forename: Sheng Hong
authors.initials: SH
authors.lastname: Qiang
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oyama
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kuno
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hirose
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D017491:Genes, APC / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin