High doses of atorvastatin (Sortis) modify the secretory process in the exocrine portion of the pancreas.
Changes were observed in the ultrastructure of the pancreatic acinar cells in rats after administration of atorvastatin (Sortis) in the therapeutic and ten times larger dose for the period of 6 weeks. It was found that atorvastatin given to rats in the therapeutic dose (80 mg/day) stimulated the secretion in pancreocytes, whereas the ten times higher dose of atorvastatin distorts the complicated process of the release of the secretion from the cell.
Czerny
Krystyna
K
Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.
Romanowska
Jadwiga
J
Kifer-Wysocka
Ewa
E
Matysiak
Włodzimierz
W
Masłyk
Teresa
T
D000818:Animals; D000069059:Atorvastatin; D002118:Calcium / Q000378:metabolism; D006538:Heptanoic Acids / Q000633:toxicity*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000633:toxicity*; D046790:Pancreas, Exocrine / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011758:Pyrroles / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D002118:Calcium