title: A design for life: prokaryotic metal-binding MerR family regulators.
abstract: The MerR family of metal-binding, metal-responsive proteins is unique in that they activate transcription from unusual promoters and coordinate metals through cysteine (and in the case of ZntR, histidine) residues. They have conserved primary structures yet can effectively discriminate metals in vivo.
authors.affiliation: School of Biosciences, The University of Birmingham, Edgbaston, UK. J.L.Hobman@bham.ac.uk
authors.forename: Jon L
authors.initials: JL
authors.lastname: Hobman
authors.forename: John
authors.initials: J
authors.lastname: Wilkie
authors.forename: Nigel L
authors.initials: NL
authors.lastname: Brown
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D001483:Base Sequence; D018360:Crystallography, X-Ray; D003545:Cysteine / Q000737:chemistry*; D003593:Cytoplasm / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D004926:Escherichia coli / Q000378:metabolism*; D006639:Histidine / Q000737:chemistry; D006860:Hydrogen Bonding; D008670:Metals / Q000737:chemistry; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000737:chemistry; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C051124:MerR protein, Bacteria; D008670:Metals; D014157:Transcription Factors; C118628:ZntR protein, bacteria; D006639:Histidine; D000251:Adenosine Triphosphatases; D003545:Cysteine