[Effect of early intestinal dripping of jianpi tongli Chinese herbs on serum level IL-2, sIL-2R and IL-12 in patients with gastric cancer after operation].
OBJECTIVE
To explore the regulation and clinical significance of intestinal dripping of Jianpi Tongli (JPTL) Chinese herbs on levels of serum cytokines, such as interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and interleukin-12 (IL-12) in treating patients with gastric cancer (GC) at early post-operational stage.


METHODS
Sixty patients with GC were randomly divided into two groups, i. e. the studied group (n = 30), treated with JPTL Chinese herbs, and the control group (n = 30) treated with normal saline. The medication was started from the 1st day after operation by intestinal dripping daily, 7 days as one course. Levels of IL-2, sIL-2R and IL-12 were observed before and after operation.


RESULTS
Significant difference was seen on the 7th day post-operation between the studied and the control group, mainly in aspects of obvious increase of IL-2 and decrease of sIL-2R (P <0.05), no significant difference in IL-12 was found (P >0.05) though there was certain improvement. Compared with pre-operation of the same group, significant difference was found in the studied group in the increased IL-2 and IL-12 and decreased sIL-2R on the 7th day post-operation, while no significant difference in these indexes was found in the control group (P >0.05), though certain improvement was shown.


CONCLUSIONS
Early intestinal dripping of JPTL Chinese herbs to post-operational patients with GC could improve their immune function, which was of important significance in early preventing the severe complications, improving the prognosis, and elevating the survival rate.
Yu
Qing-Sheng
QS
The First Affiliated Hospital, Anhui Medical University, Hefei. qingshengyu@263.net
Liu
Yi
Y
Hou
Yong
Y
Zhang
Fuzhong
F
Yi
Weizhen
W
Wang
Xiaoming
X
Shuai
Jianfeng
J
D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D018664:Interleukin-12 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood*; D007421:Intestine, Small; D007441:Intubation, Gastrointestinal; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011184:Postoperative Period; D015375:Receptors, Interleukin-2 / Q000097:blood; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery
D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D018664:Interleukin-12