[Preventive effect of 5-fluorouracil on post-ERCP pancreatitis].
OBJECTIVE
To investigate the preventive effect of 5-fluorouracil (5-FU) on post-ERCP (endoscopic retrograde cholangiopancreatography) hyperamy-lasemia and pancreatitis.


METHODS
One hundred and sixty patients who underwent ERCP were divided at random into 2 groups: group A (n = 80) was given meglumine diatrizoate with 5-FU; and group B (n = 80) was used contrast medium without 5-FU. Blood was drawn in each group the day before, 6 hours and 24 hours following ERCP for amylase.


RESULTS
Post-ERCP hyperamylasemia occurred in 9 patients in group A (11. 25%) and 45 in B (56.25%). The difference of both groups was notable. Pancreatitis ensued in 2 instances in group A (2.50%) and 8 in group B (10.00%). Their difference was significant.


CONCLUSIONS
5-FU added in meglumine diatrizoate is helpful to prevent post-ERCP hyperamylasemia and pancreatitis.
Fan
Wen-Tao
WT
Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 41001 1, China. fanwentao2002@yahoo.com.cn
Wang
Qun-Wei
QW
Li
Qing-Long
QL
D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D042882:Gallstones / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000209:etiology / Q000517:prevention & control*
D005472:Fluorouracil