title: Patterns of genotoxicity and contaminant exposure: evidence of genomic instability in the marsh frogs (Rana ridibunda) of Sumgayit, Azerbaijan.
abstract: The wetlands of Sumgayit in the Azerbaijan Republic contain complex mixtures of contaminants, including polycyclic aromatic hydrocarbons (PAHs), mercury, organochlorine pesticides, and polychlorinated biphenyls. Marsh frogs (Rana ridibunda) were collected from several contaminated wetlands within the city as well as from two reference sites outside the city. Sediment samples revealed heterogeneous patterns of PAH and mercury concentrations throughout Sumgayit, with the highest levels occurring east of the Sumgayit River, within the industrial zone. Flow cytometry and micronucleus assay revealed elevated estimates of genetic damage in frogs from the wetlands east of the Sumgayit River compared to frogs from the reference sites. Flow cytometric data showed a significant correlation with sediment mercury concentrations, whereas population micronucleus frequencies were significantly correlated with high-molecular-weight PAHs.
authors.affiliation: Department of Wildlife and Fisheries Sciences, Texas A&M University, College Station, Texas 77843-2258, USA. matson@tamu.edu
authors.forename: Cole W
authors.initials: CW
authors.lastname: Matson
authors.forename: Grigoriy M
authors.initials: GM
authors.lastname: Palatnikov
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: McDonald
authors.forename: Robin L
authors.initials: RL
authors.lastname: Autenrieth
authors.forename: K C
authors.initials: KC
authors.lastname: Donnelly
authors.forename: Todd A
authors.initials: TA
authors.lastname: Anderson
authors.forename: Jaclyn E
authors.initials: JE
authors.lastname: Canas
authors.forename: Arif
authors.initials: A
authors.lastname: Islamzadeh
authors.forename: John W
authors.initials: JW
authors.lastname: Bickham
mesh_terms: D000818:Animals; D001382:Azerbaijan; D042822:Genomic Instability; D011895:Rana ridibunda / Q000235:genetics*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D014874:Water Pollutants, Chemical