title: Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export.
abstract: [reaction: see text] Two inhibitors of FOXO1a-mediated nuclear export, psammaplysenes A and B, have been synthesized by a flexible and efficient route. A common starting material, 4-iodophenol, was used to prepare both halves of these pseudosymmetric dibromotyrosine-derived metabolites.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Savvas N
authors.initials: SN
authors.lastname: Georgiades
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D021581:Active Transport, Cell Nucleus; D051858:Forkhead Transcription Factors / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D015394:Molecular Structure; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D051858:Forkhead Transcription Factors; C501142:psammaplysene A; C512180:psammaplysene B; D014443:Tyrosine