title: Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex.
abstract: The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein-fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.
authors.affiliation: School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Belgorodsky
authors.forename: Ludmila
authors.initials: L
authors.lastname: Fadeev
authors.forename: Varda
authors.initials: V
authors.lastname: Ittah
authors.forename: Hadar
authors.initials: H
authors.lastname: Benyamini
authors.forename: Stanislav
authors.initials: S
authors.lastname: Zelner
authors.forename: Dan
authors.initials: D
authors.lastname: Huppert
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Kotlyar
authors.forename: Michael
authors.initials: M
authors.lastname: Gozin
mesh_terms: D002850:Chromatography, Gel; D045304:Cytochromes c / Q000737:chemistry / Q000378:metabolism; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D008314:Malonates / Q000737:chemistry*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D012709:Serum Albumin / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism; D014325:Tromethamine / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000737:chemistry / Q000378:metabolism
chemical_list: D037741:Fullerenes; D008314:Malonates; D012709:Serum Albumin; D014325:Tromethamine; D045304:Cytochromes c; C030290:malonic acid; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C069837:fullerene C60