title: Preimplantation testing for chromosomal disorders improves reproductive outcome of poor-prognosis patients.
abstract: The clinical impact of PGD was evaluated through the analysis of the reproductive outcome before and after PGD in the same group of poor prognosis IVF patients, undergoing PGD for chromosomal abnormalities. Based on a series of 2359 PGD cycles, resulting in the establishment of 498 chromosomal abnormality-free clinical pregnancies, the reproductive history prior to PGD was analysed. Of 483 previous pregnancies analysed in patients with 432 pregnancies generated after PGD for aneuploidies, 328 (68%) ended in spontaneous abortions, in contrast to 28.4% after PGD, with only 155 (32%) resulting in deliveries, compared with 71.9% take-home baby rates after PGD. The patients experienced 315 previous IVF attempts, resulting in the transfer of 706 embryos in 308 cycles, of which only 49 (6.9%) implanted, compared with a 34.9% implantation rate observed in the same patients after PGD. Similar analysis of the previous reproductive outcomes of 45 carriers of balanced translocations achieving pregnancies following PGD, showed even stronger clinical impact, with a reduction of spontaneous abortions from 87.8% to 17.8%, and improvement of take-home baby rate from 11.5% to 81.4% after PGD. The results demonstrate a strong clinical impact of PGD, resulting in improvement of implantation rate, reduction of spontaneous abortions and increase in the take-home baby rate.
authors.affiliation: Reproductive Genetics Institute, 2825 N Halsted St, Chicago, IL 60657, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Verlinsky
authors.forename: I
authors.initials: I
authors.lastname: Tur-Kaspa
authors.forename: J
authors.initials: J
authors.lastname: Cieslak
authors.forename: A
authors.initials: A
authors.lastname: Bernal
authors.forename: R
authors.initials: R
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Taranissi
authors.forename: B
authors.initials: B
authors.lastname: Kaplan
authors.forename: A
authors.initials: A
authors.lastname: Kuliev
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D000782:Aneuploidy; D025063:Chromosome Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D010064:Embryo Implantation; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis; D011379:Prognosis; D014178:Translocation, Genetic