title: Law and order: assessing and enforcing compliance with ontological modeling principles in the Foundational Model of Anatomy.
abstract: The objective of this study is to provide an operational definition of principles with which well-formed ontologies should comply. We define 15 such principles, related to classification (e.g., no hierarchical cycles are allowed; concepts have a reasonable number of children), incompatible relationships (e.g., two concepts cannot stand both in a taxonomic and partitive relation), dependence among concepts, and the co-dependence of equivalent sets of relations. Implicit relations--embedded in concept names or inferred from a combination of explicit relations--are used in this process in addition to the relations explicitly represented. As a case study, we investigate the degree to which the Foundational Model of Anatomy (FMA)--a large ontology of anatomy--complies with these 15 principles. The FMA succeeds in complying with all the principles: totally with one and mostly with the others. Reasons for non-compliance are analyzed and suggestions are made for implementing effective enforcement mechanisms in ontology development environments. The limitations of this study are also discussed.
authors.affiliation: U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD, USA. smzhang@math.ac.cn
authors.forename: Songmao
authors.initials: S
authors.lastname: Zhang
authors.forename: Olivier
authors.initials: O
authors.lastname: Bodenreider
mesh_terms: D000715:Anatomy / Q000706:statistics & numerical data; D002965:Classification; D006801:Humans; D008490:Medical Informatics; D008953:Models, Anatomic