title: [Study of the clinicopathology on verruciform xanthoma of the oral cavity].
abstract: OBJECTIVE
  Three cases of oral cavity mucosal verruciform xanthoma were studied to investigate the pathogenesis of verruciform xanthoma.
  
  
  METHODS
  Immunohistochemical staining with S-P and in situ hybridization using the probe to detect HPV mRNA and MMP-2, MMP-9 RNA.
  
  
  RESULTS
  The foam cells were strongly positive for CD68 (KP1) and Vimentin. The cytokeratin, PCNA and S-100 showed negative in foam cells. ISH testing failed to detect HPV (types 6, 11, 16, 18) in any of the three cases of verruciform xanthoma. MMP-2, MMP-9 showed positive staining in epithelial cells and foam cells.
  
  
  CONCLUSIONS
  Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells like that, are most likely derived from monocyte-macrophage lineage.
authors.affiliation: Department of Oral Pathology, School of Stomatology, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. hja@zju.edu.cn
authors.forename: Ji-an
authors.initials: JA
authors.lastname: Hu
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Li
authors.forename: Song-ying
authors.initials: SY
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Ying
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D005487:Foam Cells / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology*; D027383:Papillomaviridae / Q000302:isolation & purification; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D014973:Xanthomatosis / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007633:Keratins; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D018809:Proliferating Cell Nuclear Antigen; D009418:S100 Proteins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C522361:MMP2 protein, human; C579270:MMP9 protein, human