title: Protective effect of albumin on lungs injury in traumatic/hemorrhagic shock rats.
abstract: OBJECTIVE
  To determine the effect of albumin administration on lung injury in traumatic/hemorrhagic shock (T/HS) rats.
  
  
  METHODS
  Forty-eight adult Sprague-Dawley rats were divided into three groups randomly (n=16 in each group): Group A, Group B, Group C. In Group A, rats underwent laparotomy without shock. In Group B, rats undergoing T/HS were resuscitated with their blood plus lactated Ringer's (twice the volume of shed blood). In Group C, rats undergoing T/HS were resuscitated with their shed blood plus additional 3 ml of 5% human albumin. The expression of polymorphonuclear neutrophils CD18/CD11b in jugular vein blood was evaluated. The main lung injury indexes (the activity of myeloperoxidase and lung injury score) were measured.
  
  
  RESULTS
  Significant differences of the expression of CD18/11b and the severity degree of lung injury were founded between the three groups. (P<0.05). The expression of CD18/CD11b and the main lung injury indexes in Group B and Group C increased significantly compared with those in Group A (P<0.05). At the same time, the expression of CD18/CD11b and the main lung injury indexes in Group C decreased dramatically, compared those in Group B (P<0.05).
  
  
  CONCLUSIONS
  The infusion of albumin during resuscitation period can protect lungs from injury and decrease the expression of CD18/CD11b in T/HS rats.
authors.affiliation: The Department of Emergency Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Chen-yan
authors.initials: CY
authors.lastname: Ding
authors.forename: Zuo-bing
authors.initials: ZB
authors.lastname: Chen
authors.forename: Shu-sen
authors.initials: SS
authors.lastname: Zheng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xue-hong
authors.initials: XH
authors.lastname: Zhao
authors.forename: Ling-mei
authors.initials: LM
authors.lastname: Ni
mesh_terms: D000418:Albumins / Q000627:therapeutic use*; D000818:Animals; D039481:CD11b Antigen / Q000378:metabolism; D018821:CD18 Antigens / Q000378:metabolism; D004195:Disease Models, Animal; D009504:Neutrophils / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000378:metabolism; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications* / Q000378:metabolism
chemical_list: D000418:Albumins; D039481:CD11b Antigen; D018821:CD18 Antigens