title: Synthesis of cationic cardiolipin analogues.
abstract: An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents.
authors.affiliation: Research and Development Facility, NeoPharm, Inc., 1850 Lakeside Drive, Waukegan, IL 60085, USA.
authors.forename: Krishnudu
authors.initials: K
authors.lastname: Kasireddy
authors.forename: Shoukath M
authors.initials: SM
authors.lastname: Ali
authors.forename: Moghis U
authors.initials: MU
authors.lastname: Ahmad
authors.forename: Sreeti
authors.initials: S
authors.lastname: Choudhury
authors.forename: Pei-Yu
authors.initials: PY
authors.lastname: Chien
authors.forename: Saifuddin
authors.initials: S
authors.lastname: Sheikh
authors.forename: Imran
authors.initials: I
authors.lastname: Ahmad
mesh_terms: D002308:Cardiolipins / Q000737:chemistry*; D002412:Cations; D004337:Drug Carriers; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D002308:Cardiolipins; D002412:Cations; D004337:Drug Carriers; D007202:Indicators and Reagents; D010743:Phospholipids