title: Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface.
abstract: A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Shixin
authors.initials: S
authors.lastname: Ye
authors.forename: Bohdana M
authors.initials: BM
authors.lastname: Discher
authors.forename: Joseph
authors.initials: J
authors.lastname: Strzalka
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.forename: Sophia P
authors.initials: SP
authors.lastname: Wu
authors.forename: Dror
authors.initials: D
authors.lastname: Noy
authors.forename: Ivan
authors.initials: I
authors.lastname: Kuzmenko
authors.forename: Thomas
authors.initials: T
authors.lastname: Gog
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Therien
authors.forename: P Leslie
authors.initials: PL
authors.lastname: Dutton
authors.forename: J Kent
authors.initials: JK
authors.lastname: Blasie
mesh_terms: D000595:Amino Acid Sequence; D015195:Drug Design; D004579:Electron Transport; D008958:Models, Molecular; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D055672:Static Electricity; D014961:X-Ray Diffraction
chemical_list: D010455:Peptides