title: Laterality in five-year-olds conceived by intracytoplasmic sperm injection, standard in vitro fertilisation and natural conception: a European study.
abstract: OBJECTIVE
  To assess laterality in a group of European children conceived with the help of assisted reproductive therapy, or naturally conceived.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Five European countries.
  
  
  METHODS
  A total of 1525 five-year-old children divided into three groups according to conception status: naturally conceived; intracytoplasmic sperm injection (ICSI); in vitro fertilisation (IVF) group.
  
  
  METHODS
  All children were assessed using the McCarthy Scale of Children's Abilities (Motor Scale) with additional items using a comb, a spoon and an indirect measure was made of the parental handedness scores, using a questionnaire.
  
  
  METHODS
  Child handedness for drawing and writing.
  
  
  RESULTS
  Observed handedness did not differ significantly between natural conception, IVF and ICSI in girls or boys, except for ICSI-conceived girls, fewer of whom were left-handed than the naturally conceived controls, 7.0%versus 12.4% (P < 0.05), however, this was close to the population norm of 8%. The degree of parental handedness did not significantly vary in the three groups.
  
  
  CONCLUSIONS
  Laterality, as assessed by handedness, may be marginally less common in girls conceived with assisted reproductive therapies than with children conceived naturally.
authors.affiliation: Department of Child Health, Royal Free and University College Medical School, London, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Sutcliffe
authors.forename: J
authors.initials: J
authors.lastname: Barnes
authors.forename: U-B
authors.initials: UB
authors.lastname: Wennerholm
authors.forename: A
authors.initials: A
authors.lastname: Loft
authors.forename: B C
authors.initials: BC
authors.lastname: Tarlatzis
authors.forename: I
authors.initials: I
authors.lastname: Ponjaert-Kristoferson
authors.forename: M
authors.initials: M
authors.lastname: Bonduelle
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002675:Child, Preschool; D015331:Cohort Studies; D005220:Fathers / Q000706:statistics & numerical data; D005260:Female; D005306:Fertilization / Q000502:physiology*; D005307:Fertilization in Vitro; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009035:Mothers / Q000706:statistics & numerical data; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic