title: [Changes of pH and kinematic viscosity of the contents of gall-bladder at the pre-gallstone stage of cholelithiasis].
abstract: The aim of the work was to study the indicators of pH and kinematic viscosity of the contents of the gall-bladder at receiving B-portion and their changes after a 7-hour period according to the biliary sediment of patients and to establish their link to the infection. Total 31 patients aged 25-55 with biliary sediment in lumens of their gall-bladders (a general group) and 5 healthy patients (a control group) were studied by us. In all cases the markers of the virus of Hepatitis B in blood serum were determined and ultrasonic examination of gall-bladder was carried out by us prior to the duodenal intubation. B-portion was subjected to bacteriological research for aerobes and anaerobs, and pH and kinematic viscosity (eta=mm(2)/sec) were determined. The patients from the control as well as from the general group after a 7-hour period were redetermined pH and Kinematic viscosity of B-portion. Kinematic viscosity was determined with a capillary viscosimeter, and pH was fixed by a method of potentiometer. Statistical treatment was undertaken by the method of ANOLA p<0,05. During the duodenal intubation the mean value of pH within the control group was fixed at 6.74, and the mean value of the kinematic viscosity was 1.34, and after a 7-hour period the same indicators constituted 6.87 and 1.35 mm(2)/sec, respectively. The same indicators within the general group during duodenal intubation were the following: 7.26 and 1.99 mm(2)/sec, and after a 7-hour period the same indicators were 7.78 and 2.19 mm(2)/sec, respectively. There was a significant statistical difference between the mean values of pH and kinematic viscosity of the contents of gall-bladder of the patients from the control and general groups. During a 7-hour period, there was also a significant statistical difference between the changes of the same indicators. The difference was even greater in case of infection. Following the above-mentioned we can conclude that in case of sediment in the lumen of gall-bladder, inclination of pH to alkalinity and increase in kinematic viscosity of the contents is one of the most important criteria of lithogenicity of gall-bladder contents, and one of the reasons for such changes is chronic infection of a gall-bladder.
authors.forename: G T
authors.initials: GT
authors.lastname: Sulaberidze
authors.forename: B K
authors.initials: BK
authors.lastname: Rachvelishvili
authors.forename: G P
authors.initials: GP
authors.lastname: Gelbakhiani
authors.forename: Z S
authors.initials: ZS
authors.lastname: Zedania
authors.forename: A E
authors.initials: AE
authors.lastname: Berchashvili
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D002769:Cholelithiasis / Q000503:physiopathology*; D005704:Gallbladder / Q000378:metabolism* / Q000503:physiopathology* / Q000821:virology; D006509:Hepatitis B / Q000276:immunology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D012720:Severity of Illness Index; D014783:Viscosity