Effects of Tribuli saponins on left ventricular remodeling after acute myocardial infarction in rats with hyperlipidemia.
OBJECTIVE
To observe the effect of Tribuli saponins (TS) on left ventricular remodeling after acute myocardial infarction (AMI) in rats with hyperlipemia.


METHODS
A composite model of myocardial infarction and hyperlipemia was established and treated with TS to observe its effect on cardiac structure and function by echocardiography.


RESULTS
(1) Cardiac function: As compared with the model group, the fractional shortening (FS) and ejection fraction (EF) got increased, and the left ventricular end diastolic volume (LVEDV) and systolic volume (LVESV) got lower in the groups treated with high dose TS and simvastatin (P < 0.05 or P < 0.01), but difference between the two treated groups was insignificant. (2) Cardiac structure: As compared with the model group, the left ventricular dimension end diastole (LVDd) and systole (LVDs) in the groups treated with high dose TS and simvastatin got lower (P < 0.05 or P < 0.01). No treatment showed any effect on the thickness of ventricular wall. (3)Ventricular weight index: Both high dose TS and simvastatin could decrease the left ventricular weight index (LVWI) (P < 0.05).


CONCLUSIONS
TS could attenuate the left ventricular remodeling after acute myocardial infarction to certain extent, and improve cardiac function in the early phase after AMI, thus playing an important role in controlling morbidity and mortality of cardiac events and long-term prognosis.
Guo
Yan
Y
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing.
Yin
Hui-jun
HJ
Shi
Da-zhuo
DZ
Chen
Ke-ji
KJ
D000818:Animals; D006332:Cardiomegaly / Q000188:drug therapy / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004452:Echocardiography; D006352:Heart Ventricles / Q000473:pathology; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology*; D032444:Tribulus; D020257:Ventricular Remodeling / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D008055:Lipids; D012503:Saponins