Cells in the respiratory and intestinal tracts of chickens have different proportions of both human and avian influenza virus receptors.
Avian influenza viruses play a crucial role in the creation of human pandemic viruses. In this study, we have demonstrated that both human and avian influenza receptors exist in cells in the respiratory and intestinal tracts of chickens. We have also determined that primarily cultured chicken lung cells can support the replication of both avian and human influenza viruses.
Kim
Jin A
JA
College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Republic of Korea.
Ryu
Si Yun
SY
Seo
Sang Heui
SH
D000818:Animals; D002478:Cells, Cultured; D002645:Chickens / Q000378:metabolism*; D003106:Colon / Q000378:metabolism* / Q000821:virology; D005434:Flow Cytometry; D006801:Humans; D009980:Influenza A virus / Q000378:metabolism* / Q000502:physiology; D008168:Lung / Q000378:metabolism* / Q000821:virology; D011991:Receptors, Virus / Q000096:biosynthesis* / Q000302:isolation & purification / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology
D011991:Receptors, Virus