title: Local delivery of magnetic resonance (MR) contrast agent in kidney using thermosensitive liposomes and MR imaging-guided local hyperthermia: a feasibility study in vivo.
abstract: OBJECTIVE
  To investigate the feasibility of local delivery of a magnetic resonance (MR) contrast agent in vivo using paramagnetic thermosensitive liposomes and infrared (IR) laser-induced local hyperthermia under real-time MR thermometry on rabbit kidney.
  
  
  METHODS
  Respiratory gated, radio frequency (RF)-spoiled gradient-echo sequences were used for precise MR temperature mapping (SD = 1 degrees C). In vivo heating experiments confirmed local release of MR contrast agent from liposomes.
  
  
  RESULTS
  T1 decreased from 800 msec to about 500 msec, as measured after tissue cooling, in those locations where the renal parenchyma was heated above the phase transition temperature of the liposome membrane.
  
  
  CONCLUSIONS
  The release of MR contrast agent has been demonstrated in rabbit kidney in vivo. This may be used as a reporter for simultaneous release of therapeutic agents.
authors.affiliation: Molecular and Functional Imaging, Technological Research Unit, CNRS/University of Bordeaux 2, Bordeaux, France.
authors.forename: Rares
authors.initials: R
authors.lastname: Salomir
authors.forename: Jean
authors.initials: J
authors.lastname: Palussière
authors.forename: Sigrid L
authors.initials: SL
authors.lastname: Fossheim
authors.forename: Astri
authors.initials: A
authors.lastname: Rogstad
authors.forename: Unni N
authors.initials: UN
authors.lastname: Wiggen
authors.forename: Nicolas
authors.initials: N
authors.lastname: Grenier
authors.forename: Chrit T W
authors.initials: CT
authors.lastname: Moonen
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005240:Feasibility Studies; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D007668:Kidney / Q000378:metabolism*; D008081:Liposomes; D008279:Magnetic Resonance Imaging; D011817:Rabbits; D013696:Temperature
chemical_list: D003287:Contrast Media; D008081:Liposomes