title: [Correlation analysis of increase in serum level of leptin with that of C reactive protein, troponin T and endothelin in patients with acute myocardial infarction].
abstract: OBJECTIVE
  To determine serum leptin levels in patients with acute myocardial infarction (AMI) and coronary atherosclerosis (CS), and to analyze its correlation with C reactive protein (CRP), troponin T (TnT) and endothelin (ET).
  
  
  METHODS
  Serum samples from confirmed AMI and CS patients were collected. Leptin and ET were assayed with high sensitive radioimmunoassay, TnT was determined with automatic biochemical analyser, and CRP was determined with enzyme-linked immunosorbant assay (ELISA).
  
  
  RESULTS
  Compared with normal control group, serum leptin, TnT, CRP and ET levels increased significantly (all P<0.01) in AMI patients. Serum levels of other cytokines, except TnT in CS patients, increased significantly compared with normal control group (all P<0.01). Correlation analysis showed that all the changes were not correlated with each other, each being an independent factor. Only serum TnT levels of AMI and CS patients showed a significant difference (P<0.01).
  
  
  CONCLUSIONS
  Serum leptin levels of both AMI and CS patients increase significantly without a significant difference between each other, and there is no correlation for leptin with CRP, TnT and ET.
authors.affiliation: Research Laboratory of Biochemistry, Basic Medical Research Institute, General Hospital of PLA, Beijing 100853, China. YAN301@263.net
authors.forename: Guang-tao
authors.initials: GT
authors.lastname: Yan
authors.forename: Hui
authors.initials: H
authors.lastname: Xue
authors.forename: Ji
authors.initials: J
authors.lastname: Lin
authors.forename: Xiu-hua
authors.initials: XH
authors.lastname: Hao
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Lu-huan
authors.initials: LH
authors.lastname: Wang
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood; D016232:Endothelins / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D016232:Endothelins; D020738:Leptin; D020107:Troponin T; D002097:C-Reactive Protein