title: Can we simplify the 100-g oral glucose tolerance test in pregnancy?
abstract: The aim of this study was to investigate if the omission of one of the glucose measurements in the 100-g oral glucose tolerance test (100-g OGTT) would have influenced the final diagnosis of GDM in a Brazilian cohort. We performed a retrospective study with 75 patients with GDM. The 100-g OGTT test was performed in 65 of these women. Twenty (30.76%), 24 (36.92%) and 21 (32.32%), respectively, had two, three and four values above the normal range. The mean fasting, 1, 2 and 3h glycemia were 109.81 +/- 33.34, 206.55 +/- 44.09, 188.13 +/- 46.52 and 142.12 +/- 49.53 mg/dl, respectively. They were above the cut-off values in 52 (80%), 55 (84.61%), 56 (86.1%) and 31 (47.6%) tests. The exclusion of the 1st, 2nd and 3rd measurements would have missed, respectively, 9 (10.5%), 16 (18.8%) and 13 (15.2%) cases. The omission of the 4th measurement would miss one case (1.17%). In conclusion, in our study, the omission of the last glucose measurement in the 3 h 100-g OGTT would not have caused a significant impact on the final diagnosis of GDM. Therefore, given the potential advantages of simplifying the test in terms of cost and convenience, the abbreviation of the 100-g OGTT should be considered.
authors.affiliation: Diabetes and Maternal-Fetal Sections, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. melanie.rodacki@joslin.harvard.edu
authors.forename: Melanie
authors.initials: M
authors.lastname: Rodacki
authors.forename: Paulo G S
authors.initials: PG
authors.lastname: Lacativa
authors.forename: Giovanna A B
authors.initials: GA
authors.lastname: Lima
authors.forename: Patricia C
authors.initials: PC
authors.lastname: Peixoto
authors.forename: Analzira G A
authors.initials: AG
authors.lastname: Loureiro
authors.forename: Marcia B
authors.initials: MB
authors.lastname: Wagman
authors.forename: Lenita
authors.initials: L
authors.lastname: Zajdenverg
mesh_terms: D001938:Brazil; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies