Efforts toward the total synthesis of (-)-kendomycin.
[structure: see text] The synthesis of an advanced component leading to (-)-kendomycin is described. The synthetic scheme features the application of asymmetric conjugate addition methodology for the early generation of the C13-C14 (E)-trisubstituted olefin, providing an efficient assembly of the ansa chain. Condensation reactions probe two strategies for attachment of the aromatic system.
Williams
David R
DR
Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, Indiana 47405, USA. williamd@indiana.edu
Shamim
Khalida
K
D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D015394:Molecular Structure; D017828:Rifabutin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D000447:Aldehydes; D000475:Alkenes; C485395:kendomycin; D017828:Rifabutin