Increased plasma levels of TNF-alpha but not of IL1-beta in MPTP-treated monkeys one year after the MPTP administration.
The cause of Parkinson's disease remains unknown although some evidence suggests that an inflammatory reaction, mediated by cytokines such as TNF-alpha and IL-1beta, is related with dopaminergic degeneration in the brain. In the present work we measured the plasma levels of TNF-alpha and IL-1beta in parkinsonian monkeys one year after MPTP administration. TNF-alpha levels were seen to have increased in parkinsonian monkeys reflecting the clinical symptoms observed, while IL-1beta levels remained unchanged. These results suggest that TNF-alpha plays a role in sustaining of dopaminergic degeneration in chronic parkinsonism.
Barcia
Carlos
C
Experimental Neurology and Neurosurgery, Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain. barcia@um.es
de Pablos
Vicente
V
Bautista-Hernández
Víctor
V
Sánchez-Bahillo
Angel
A
Bernal
Inmaculada
I
Fernández-Villalba
Emiliano
E
Martín
Javier
J
Bañón
Rafael
R
Fernández-Barreiro
Andrés
A
Herrero
María-Trinidad
MT
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000502:physiology; D007375:Interleukin-1 / Q000097:blood*; D008252:Macaca fascicularis; D008297:Male; D009410:Nerve Degeneration / Q000097:blood / Q000276:immunology; D009498:Neurotoxins / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000097:blood / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007375:Interleukin-1; D009498:Neurotoxins; D014409:Tumor Necrosis Factor-alpha; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine