title: Leukemia inhibitory factor (LIF) and its biological activity.
abstract: Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It shows a wide range of biologic activities that include the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.
authors.affiliation: Chair and Department of Dermatology, Skubiszewski Medical University of Lublin.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Chodorowska
authors.forename: Anna
authors.initials: A
authors.lastname: Głowacka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Tomczyk
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation / Q000209:etiology; D015850:Interleukin-6 / Q000502:physiology*; D053605:Leukemia Inhibitory Factor; D009490:Neurosecretory Systems / Q000502:physiology
chemical_list: D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor