title: Experimental study of treatment effectiveness of the natural drug--Naran S in inflammatory conditions of the oral cavity in animals.
abstract: The aim of the study was the evaluation of the action of a new natural drug--Naran S, elaborated in the Department of Inorganic Chemistry of the Medical University of Lublin (patent registration P.332066) in the treatment of inflammatory conditions of the oral cavity mucous membrane. The experiment was conducted on male Wistar rats. Topical inflammation of the gum was induced by injecting a complete Freund adjuvant (AF) (Calbiochem) into the inter-dental papilla of the lower incisors. The material was taken, fixed and stained with hematoxylin and eosin and by the use of the Masson's method after 24 hours, 1, 2, and 4 weeks following the injection time. Morphology of the mucous membrane was examined and it was noticed that in the group treated with Naran S infusion the complete rebuilding of the epithelial strata, collagen fibres took place. The shape of the cells was regular and there occurred the elimination of the tissue fluid in the proper mucous membrane. The results obtained in the study allow to claim that the topically given plant drug thanks to its contents of biologically active substance such as: iridoids, flavonoids, phenol acids, tannins, displays curative activity in the therapy of the inflammatory conditions of the oral cavity mucous membrane.
authors.affiliation: Department of Inorganic Chemistry, Skubiszewski Medical University of Lublin.
authors.forename: Iwona
authors.initials: I
authors.lastname: Wołoszyn
authors.forename: Grazyna
authors.initials: G
authors.lastname: Matysik
authors.forename: Mirosław
authors.initials: M
authors.lastname: Lańcut
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D005419:Flavonoids / Q000494:pharmacology*; D005620:Freund's Adjuvant; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D005891:Gingivitis / Q000188:drug therapy* / Q000473:pathology; D039823:Iridoids / Q000494:pharmacology*; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009067:Mouthwashes / Q000494:pharmacology*; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology; D010519:Periodontium / Q000187:drug effects / Q000473:pathology; D010636:Phenols / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D039823:Iridoids; D009067:Mouthwashes; C504357:Naran S; D010636:Phenols; D010936:Plant Extracts; D013634:Tannins; D005620:Freund's Adjuvant