Ultrastructure of the hepatocytes after application of azithromycin (Sumamed).
Azithromycin (Sumamed, PLIVA Cracow) was administered intragastrically to rats in doses 10 times and 100 times bigger than the therapeutic dose (according to the indications for a 5-day treatment). Ultrastructural examinations of the liver were performed. Changes observed in the morphology of hepatocytes and Browicz-Kupffer cells (swelling of mitochondria, more numerous lysosomes, weaker RER content and granular material inside biliary canaliculi) may indicate temporary violation of the functional equilibrium in the liver due to the application of azithromycin.
Romanowska-Sarlej
Jadwiga
J
Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.
Matysiak
Włodzimierz
W
Kifer-Wysocka
Ewa
E
Czerny
Krystyna
K
Masłyk
Teresa
T
Piskórz
Janusz
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D017963:Azithromycin / Q000633:toxicity*; D022781:Hepatocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D017963:Azithromycin