title: Compositional variation in bacterial genes and proteins with potential expression level.
abstract: Usage of guanine and cytosine at three codon sites in eubacterial genes vary distinctly with potential expressivity, as predicted by Codon Adaptation Index (CAI). In bacteria with moderate/high GC-content, G(3) follows a biphasic relationship, while C(3) increases with CAI. In AT-rich bacteria, correlation of CAI is negative with G(3), but non-specific with C(3). Correlations of CAI with residues encoded by G-starting codons are positive, while with those by C-starting codons are usually negative/random. Average Size/Complexity Score and aromaticity of gene-products decrease with CAI, confirming general validity of cost-minimization principle in free-living eubacteria. Alcoholicity of bacterial gene-products usually decreases with expressivity.
authors.affiliation: Bioinformatics Center, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700 032, India.
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Das
authors.forename: Subhagata
authors.initials: S
authors.lastname: Ghosh
authors.forename: Archana
authors.initials: A
authors.lastname: Pan
authors.forename: Chitra
authors.initials: C
authors.lastname: Dutta
mesh_terms: D000596:Amino Acids; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003062:Codon; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D016366:Open Reading Frames
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D003062:Codon