High-dose streptokinase in the treatment of acute massive pulmonary embolism complicated with cardiogenic shock, respiratory arrest and ventricular fibrillation.
BACKGROUND
Despite advances in prophylaxis, diagnostic modalities, and therapeutic options, pulmonary embolism remains a commonly undiagnosed entity with lethal outcome. Clinically, pulmonary embolism ranges from massive thromboembolism with cardiogenic shock to asymptomatic, microebolism with anatomically small emboli without hemodynamic, respiratory or other disturbances.


METHODS
A patient with massive pulmonary embolism complicated with ventricular fibrillation, respiratory arrest and cardiogenic shock was treated with a total dose of 3 750 000 IU of intravenous streptokinase in the 8-hour time period. After successful cardiopulmonary resuscitation, and thrombolytic therapy, the patient regained hemodynamic stability six hours after admission; all clinical and electrocardiographic signs of the right ventricle insufficiency disappeared.


CONCLUSIONS
This case report suggested that treatment with the high-dose of streptokinase could be beneficial in the patients with massive pulmonary embolism complicated with cardiogenic shock, which must be confirmed by further randomized trials.
Lasica
Ratko
R
Clinical Center of Serbia, Cardiology Department, Emergency Center, Institute for Cardiovascular Diseases, Belgrade, Serbia and Montenegro. Iratko@ptt.yu
Perunicić
Jovan
J
Mrdović
Igor
I
Stojanović
Radan
R
Vasiljević
Zorana
Z
D000208:Acute Disease; D000368:Aged; D016887:Cardiopulmonary Resuscitation; D005260:Female; D006323:Heart Arrest / Q000150:complications* / Q000628:therapy; D006801:Humans; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy*; D012131:Respiratory Insufficiency / Q000150:complications*; D012770:Shock, Cardiogenic / Q000150:complications*; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D020246:Venous Thrombosis / Q000150:complications; D014693:Ventricular Fibrillation / Q000150:complications*
D013300:Streptokinase