Molecular pathogenesis of diffuse large B-cell lymphoma.
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathologic entity accounting for 30% of non-Hodgkin's lymphomas. The pathogenesis of DLBCL is complex and heterogeneous. Recent studies using analysis of global gene expression with DNA microarrays and the classical molecular approaches demonstrate presence of several DLBCL subtypes characterized by different cells of origin, cytogenetic and molecular aberrations, and distinct pathogenesis. This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis.
Lossos
Izidore S
IS
University of Miami, Sylvester Comprehensive Cancer Center, Department of Hematology and Oncology, 1475 NW 12th Ave (D8-4), Miami, FL 33136, USA. ilossos@med.miami.edu
D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008967:Molecular Biology; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014178:Translocation, Genetic / Q000235:genetics*