title: Management of intracranial hemorrhage in patients with mechanical circulatory support: a role for low-molecular-weight heparins?
abstract: Patients on mechanical circulatory support are at high risk of bleeding, particularly intracranial hemorrhage (ICH). The management of ICH in patients needing anticoagulation and antiplatelet therapies remains a challenge. We report our initial experience of ICH management with low-molecular-weight heparin in patients with mechanical circulatory support, without bleeding or thromboembolic complications.
authors.affiliation: Department of Cardiac Surgery and CNRS-UMR 7054, Henri Mondor Hospital, Créteil, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Vermes
authors.forename: Matthias
authors.initials: M
authors.lastname: Kirsch
authors.forename: Titi
authors.initials: T
authors.lastname: Farrokhi
authors.forename: Bernadette
authors.initials: B
authors.lastname: Boval
authors.forename: Eliane
authors.initials: E
authors.lastname: Melon
authors.forename: Daniel
authors.initials: D
authors.lastname: Loisance
authors.forename: Ludovic
authors.initials: L
authors.lastname: Drouet
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage* / Q000627:therapeutic use*; D004452:Echocardiography; D017984:Enoxaparin / Q000008:administration & dosage / Q000627:therapeutic use; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000150:complications; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D065427:Factor Xa Inhibitors; D006495:Heparin, Low-Molecular-Weight; D015951:Factor Xa