Pulmonary non-caseating granuloma in Waldenström macroglobulinemia.
Lung involvement is rare in Waldenström macroglobulinemia (WM). We encountered a male patient with WM who complained of breathlessness. Chest X-ray revealed diffuse infiltrative shadow throughout the both lungs. Transbronchial biopsy showed infiltration of atypical plasmacytoid lymphocytes and non-caseating granuloma. We treated the patients with fludarabine phosphate, and both his symptom and X-ray findings were then improved. To our knowledge, this is the first case showing non-caseating granuloma with lung involvement of WM. We discuss a mechanism of non-caseating granuloma formation in this case.
Fukuda
Ryuki
R
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan. f.ryuki@is.icc.u-tokai.ac.jp
Kawada
Hiroshi
H
Ogawa
Yoshiaki
Y
Yanagi
Hidetaka
H
Kojima
Seiichiro
S
Urano
Tetsuya
T
Chie
Ito
I
Onizuka
Makoto
M
Fukagawa
Satomi
S
Shimada
Masako
M
Suzuki
Rikio
R
Takagi
Atsushi
A
Hotta
Tomomitsu
T
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016726:Plasma Cell Granuloma, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011859:Radiography; D016896:Treatment Outcome; D001084:Vidarabine Phosphate / Q000031:analogs & derivatives / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy
D000964:Antimetabolites, Antineoplastic; D001084:Vidarabine Phosphate; C042382:fludarabine phosphate