Histopathological differences in the development of small intestinal metaplasia between antrum and body of stomach.
This study used mucin immunohistochemistry to investigate differences in the properties of intestinal metaplasia between the antrum and body of the stomach in 28 resected specimens. Intestinal metaplasia was classified as: (1) small intestinal metaplasia (SIM) with a tubule, including CD10-positive brush border on a background of MUC5AC-/ HGM-negative cells; or (2) goblet cell metaplasia (GCM) with MUC2-positive and CD10-negative cells. In the antrum, frequencies of SIM and GCM were nearly equal irrespective of metaplasia grade. Frequency and length of remnant pyloric gland for SIM were significantly greater in the antrum than in the body. In the proliferative zone, there existed a lower level in SIM than in non-intestinalized tubules. These findings suggest that the proliferative zone shifts from the neck zone toward the bottom of the tubule during the SIM process in the antrum. In the body, however, the grade of SIM grade was significantly higher than that of GCM. The proliferative zone was located higher in the fundic gland, pseudopyloric gland and SIM, in that order. Almost all remnant pyloric glands for SIM were negative for pepsinogen I. These facts indicate that SIM in the body originates in a proliferative zone that shifted downward to an area near the bottom of the tubule, with atrophic pyloric glands originating from pseudopyloric gland metaplasia.
Ikeda
Yoshiyuki
Y
Division of Molecular and Diagnostic Pathology, Department of Molecular Genetics, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan. yikeda@med.niigata-u.ac.jp
Nishikura
Ken
K
Watanabe
Hidenobu
H
Watanabe
Gen
G
Ajioka
Yoichi
Y
Hatakeyama
Katsuyoshi
K
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D020397:Goblet Cells / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000473:pathology*; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism; D015260:Neprilysin / Q000378:metabolism; D011706:Pyloric Antrum / Q000378:metabolism / Q000473:pathology*; D011708:Pylorus / Q000378:metabolism / Q000473:pathology*
D009077:Mucins; D015260:Neprilysin