title: [Genetic variants of Borrelia afzelii, a pathogen of the ixodes tick borrelioses].
abstract: Borrelia afzelii is one of two most important pathogens of the ixodes tick borrelioses (ITB) in Russia and neighboring countries. This pathogen circulates in various ecosystems and has a wide range of reservoir hosts and transmitters. The results of studies of genetic heterogeneity of the spirochaetae B. afzelii are considered. A total of 139 primary isolates were studied. The isolates were isolated from three species of Ixodes ticks at different stages of development and obtained from the laboratory of infection transmitters, Gamaleya Scientific Research Institute of Epidemiology and Microbiology, Russran Academy of Medical Sciences, Moscow. The transmitters and reservoir hosts of borrelias were caught in natural foci of Russia (from Kaliningrad region irk the west to south Sakhalin in the east), Czechia, Lithuania, Estonia, Ukraine, and Moldavia. Analysis of genotype sequence similarity obtained by sequencing of the rrf(SS)-rrl(23S) spacer demonstrated that the B. afzelii genospecies incorporated no less than 10 genetic variants of spirochaetae, most variants being geographically widespread.
authors.forename: I A
authors.initials: IA
authors.lastname: Fadeeva
authors.forename: V V
authors.initials: VV
authors.lastname: Nefedova
authors.forename: E I
authors.initials: EI
authors.lastname: Korenberg
authors.forename: N B
authors.initials: NB
authors.lastname: Gorelova
mesh_terms: D000818:Animals; D015748:Borrelia burgdorferi Group / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D014644:Genetic Variation; D018884:Ixodes / Q000382:microbiology; D008193:Lyme Disease / Q000382:microbiology*; D010802:Phylogeny; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D012341:RNA, Ribosomal, 5S / Q000235:genetics
chemical_list: D021903:DNA, Ribosomal Spacer; D012338:RNA, Ribosomal, 23S; D012341:RNA, Ribosomal, 5S