title: Effects of aging on regional cerebral blood flow assessed by using technetium Tc 99m hexamethylpropyleneamine oxime single-photon emission tomography with 3D stereotactic surface projection analysis.
abstract: OBJECTIVE
  Although many previous reports have described age-related changes in regional cerebral blood flow (rCBF), none has used 3D stereotactic surface projection (3D-SSP) analysis, which is able to detect subtle and significant changes in rCBF.
  
  
  METHODS
  The subjects were 31 healthy volunteers (16 men and 15 women; 50-79 years of age) without abnormal MR imaging and MR angiographic findings, cognitive impairment, or depression. For each subject, rCBF was evaluated by using technetium Tc 99m-radiolabeled hexamethylpropyleneamine oxime single-photon emission CT. Maps of rCBF were compared among different age groups (50-59, 60-69, and 70-79 years of age) by using 3D-SSP. The mean z score for each gyrus was calculated for each age group by using a recently developed stereotactic extraction estimation method.
  
  
  RESULTS
  Significant age-related reductions in rCBF were seen in the bilateral cingulate gyri, left inferior gyrus, bilateral medial frontal gyri, left subcallosal gyrus, and left superior temporal gyrus. Extensive and constant reduction in rCBF occurred with increasing age in the bilateral anterior cingulate gyri, and the mean z score for this region was the highest among all the regions examined.
  
  
  CONCLUSIONS
  The 3D-SSP analysis revealed that the greatest reduction in rCBF occurred within the bilateral anterior cingulate gyri in normal middle-aged and older subjects.
authors.affiliation: Department of Neurology, School of Medicine, Shimane University, Shimane, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Shotai
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D002560:Cerebrovascular Circulation; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime