title: Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.
abstract: High levels of beta-methylamino-l-alanine (BMAA), a putative neurotoxin, have been reported in brain samples from Chamorros and patients with Alzheimer disease (AD) from western Canada. The authors assayed free BMAA in the brains of five control subjects and five patients with AD from the US Pacific Northwest as well as Chamorros with and without Parkinson-dementia complex. In contrast to others, they detected no free BMAA in any of these samples.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98104, USA. tmontine@u.washington.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Montine
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Perl
authors.forename: Douglas
authors.initials: D
authors.lastname: Galasko
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D000599:Amino Acids, Diamino / Q000032:analysis / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D001923:Brain Chemistry / Q000502:physiology; D002170:Canada; D000087522:Cyanobacteria Toxins; D004781:Environmental Exposure; D005260:Female; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D015203:Reproducibility of Results
chemical_list: D000599:Amino Acids, Diamino; D000087522:Cyanobacteria Toxins; C001824:beta-N-methylamino-L-alanine