The role of lactadherin in the phagocytosis of phosphatidylserine-expressing sickle red blood cells by macrophages.
Lactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages. Less than 0.5% of normal circulating red cells showed any binding to lactadherin. However, the red cells from patients with sickle cell disease showed 2 to 10-fold increases in lactadherin binding. Further, lactadherin stimulated the phagocytosis of sickle red blood cells by macrophages suggesting a potential role in sickle red cell clearance.
Dasgupta
Swapan K
SK
Thiagarajan
Perumal
P
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D000954:Antigens, Surface / Q000097:blood*; D004913:Erythrocytes, Abnormal / Q000378:metabolism*; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D008875:Middle Aged; D008894:Milk Proteins / Q000097:blood*; D010587:Phagocytosis / Q000502:physiology*; D010718:Phosphatidylserines / Q000096:biosynthesis* / Q000097:blood* / Q000235:genetics; D011485:Protein Binding
D000954:Antigens, Surface; C098942:MFGE8 protein, human; D008894:Milk Proteins; D010718:Phosphatidylserines