title: Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics.
abstract: Benzo[d]isoselenazol-3-ones N-substituted with sterically hindered diamagnetic and paramagnetic five- or six-membered nitroxides or their precursors, including ring-opened diselenides, exhibit synergism in glutathione peroxidase (GPx) activity.
authors.affiliation: Institute of Organic and Medicinal Chemistry, University of Pécs, P. O. Box 99, H-7602, Pécs, Hungary.
authors.forename: Tamas
authors.initials: T
authors.lastname: Kálai
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Mugesh
authors.forename: Gouriprasanna
authors.initials: G
authors.lastname: Roy
authors.forename: Helmut
authors.initials: H
authors.lastname: Sies
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Berente
authors.forename: Kálmán
authors.initials: K
authors.lastname: Hideg
mesh_terms: D000588:Amines / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism*; D018716:Molecular Mimicry; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000737:chemistry
chemical_list: D000588:Amines; D000975:Antioxidants; D016566:Organoselenium Compounds; D009569:Nitric Oxide; D005979:Glutathione Peroxidase