title: Compatibility of ondansetron hydrochloride and methylprednisolone sodium succinate in multilayer polyolefin containers.
abstract: OBJECTIVE
  The compatibility of ondansetron hydrochloride and methylprednisolone sodium succinate in 5% dextrose injection and 0.9% sodium chloride injection was studied.
  
  
  METHODS
  Test solutions of ondansetron hydrochloride 0.16 mg/mL and methylprednisolone sodium succinate 2.4 mg/mL were prepared in triplicate and tested in duplicate. Total volumes of 4 and 2 mL of ondansetron hydrochloride solution and methylprednisolone sodium succinate solution, respectively, were added to 50-mL multilayer polyolefin bags containing 5% dextrose injection or 0.9% sodium chloride injection. Bags were stored for 24 hours at 20-25 degrees C and for 48 hours at 4-8 degrees C. Chemical compatibility was measured with high-performance liquid chromatography, and physical compatibility was determined visually.
  
  
  RESULTS
  Ondansetron hydrochloride was stable for up to 24 hours at 20-25 degrees C and up to 48 hours at 4-8 degrees C. Methylprednisolone sodium succinate was stable for up to 48 hours at 4-8 degrees C. When stored at 20-25 degrees C, methylprednisolone sodium succinate was stable for up to 7 hours in 5% dextrose injection and up to 24 hours in 0.9% sodium chloride injection. Compatibility data for solutions containing ondansetron hydrochloride plus methylprednisolone sodium succinate revealed that each drug was stable for up to 24 hours at 20-25 degrees C and up to 48 hours at 4-8 degrees C.
  
  
  CONCLUSIONS
  Ondansetron 0.16 mg/mL (as the hydrochloride) and methylprednisolone 2.4 mg/mL (as the sodium succinate) mixed in 50-mL multilayer polyolefin bags were stable in both 5% dextrose injection and 0.9% sodium chloride injection for up to 24 hours at 20-25 degrees C and up to 48 hours at 4-8 degrees C.
authors.affiliation: Pharmacy Service, Caremeau Hospital Medical Center, Place du Professeur Debré, 3000 Nîmes, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Bougouin
authors.forename: Chloë
authors.initials: C
authors.lastname: Thelcide
authors.forename: Fabienne
authors.initials: F
authors.lastname: Crespin-Maillard
authors.forename: Christian
authors.initials: C
authors.lastname: Maillard
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Kinowski
authors.forename: Mireille
authors.initials: M
authors.lastname: Favier
mesh_terms: D000932:Antiemetics / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004344:Drug Incompatibility; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D005947:Glucose; D007262:Infusions, Intravenous; D008775:Methylprednisolone / Q000737:chemistry*; D017294:Ondansetron / Q000737:chemistry*; D019999:Pharmaceutical Solutions; D011090:Polyenes; D012965:Sodium Chloride; D013696:Temperature
chemical_list: D000932:Antiemetics; D019999:Pharmaceutical Solutions; D011090:Polyenes; D012965:Sodium Chloride; D017294:Ondansetron; C035051:PL 732; D005947:Glucose; D008775:Methylprednisolone