[Experimental study on changes in myocardial systolic function and arterial blood gases after impact injury to liver in rabbits].
OBJECTIVE
To explore the effects of impact injury of liver on myocardial systolic function and arterial blood gases in rabbits.


METHODS
A model of hepatic impact injury was reproduced in rabbits by hitting the xiphoid area with two falling steel balls. Myocardial systolic function and arterial blood gases were measured respectively before injury, immediately and 0.5, 1, 2 hours after injury, and before the death.


RESULTS
After injury, heart rate (HR), left ventricular systolic pressure (LVSP), the maximum change rate of left ventricular pressure rise and fall (+/-dp/dt max) descended significantly, while left ventricular end-diastolic pressure (LVEDP) showed no statistically significant change. At the same time, blood pH and HCO(3)(-) fell gradually, and negative base excess (BEecf) showed a significant increase, indicating metabolic acidosis gradually developed. There was no obvious significant difference in partial pressure of carbon dioxide in artery (PaCO(2)) between the values before and after injury. Partial pressure of oxygen in artery (PaO(2)) decreased gradually, but no significant differences were found between the values of 0.5 hour and 1 hour after injury and that before injury.


CONCLUSIONS
After hepatic impact injury, myocardial systolic function deteriorates, metabolic acidosis appears.
Sun
Shi-jin
SJ
The Center of War and Trauma, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Ma
Xiao-lin
XL
Zhou
Xue-wu
XW
Liu
Liang-ming
LM
D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D005260:Female; D008099:Liver / Q000293:injuries*; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D013599:Systole / Q000502:physiology*