title: Circadian rhythms in Neurospora crassa: clock gene homologues in fungi.
abstract: Computer-based analysis of a total of 17 filamentous fungal and yeasts genomes has shown: (1) homologues of frq, wc-1, wc-2, and vvd, key gene components of the Neurospora crassa clock, are present in Magnaporthe grisea, Gibberella zeae, and Podospora anserina, suggesting an frq-based oscillator in these organisms; (2) some fungal species that are more distantly related to Neurospora, such as Rhizopus oryzae do not appear to have frq homologues; (3) many fungal species that do not appear to contain frq, such as Aspergillus nidulans, do contain wc homologues; (4) of 11 well-described genes classified as clock-controlled genes (ccgs), in Neurospora, all of them were found to have homologues in other fungi; (5) the ccg-8 gene of N. crassa has homologies to opi1p, a transcriptional regulatory gene in Saccharomyces cerevisiae involved in inositol regulation. This suggests the possibilities of rhythmic inositol regulation, and/or a cascade of rhythmic activation of other genes in N. crassa.
authors.affiliation: Division of Biological Sciences, Molecular Biology, UCSD, La Jolla, CA 92093-0116, USA.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Lombardi
authors.forename: Stuart
authors.initials: S
authors.lastname: Brody
mesh_terms: D001683:Biological Clocks / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D019295:Computational Biology; D015966:Gene Expression Regulation, Fungal; D009492:Neurospora crassa / Q000235:genetics* / Q000502:physiology