title: Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study.
abstract: OBJECTIVE
  The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988.
  
  
  METHODS
  A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36,456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders.
  
  
  RESULTS
  Compared to women with BMI of 18.5-24.9 kg/m2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of > or = 30 kg/m2. A test for trend revealed that this finding was statistically significant (P = 0.014).
  
  
  CONCLUSIONS
  The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.
authors.affiliation: Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan. niwa@aichi-cc.jp
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Niwa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuya
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nishio
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kondo
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Akio
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
authors.forename: Hideaki
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002277:Carcinoma / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D010051:Ovarian Neoplasms / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires