[Stiff-person syndrome--two Hungarian cases and review of the literature].
The stiff-man syndrome is a rare neurological disorder characterized by progressive stiffness of the axial muscles and co-contraction of agonist and antagonist muscles sometimes accompanied by involuntary sudden muscle spasms. The disease is thought to be caused by immunological changes leading to a GABA transmission disturbance, but the precise pathogenesis is not clear. Two Hungarian cases are presented in this article accompanied by a review of the literature. The aim of the paper is to call the attention on this presumably underdiagnosed disease. The diagnostic laboratory tests of the disease are available in Hungary.
Lengyel
András
A
Debreceni Egyetem, Orvos-és Egészségtudományi Centrum, Neurológiai Klinika, Debrecen. alengyel@jaguar.dote.hu
Lakos
Gabriella
G
Sipka
Sándor
S
Hegedus
Katalin
K
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D016750:Stiff-Person Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy