Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task.
A combination of sub-effective doses of thioperamide (7.5 mg/kg, i.p.) and tacrine (0.5 mg/kg, i.p.) enhanced performance in a spatial memory task in mice. This was shown by a significant increase in their spontaneous alternation scores in a cross maze test.
Vohora
Divya
D
Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India. divyavohora@hotmail.com
Pal
Shanthi N
SN
Pillai
K K
KK
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006633:Histamine Antagonists / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000494:pharmacology; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D013619:Tacrine / Q000008:administration & dosage / Q000494:pharmacology*
D006633:Histamine Antagonists; D010277:Parasympathomimetics; D010880:Piperidines; D013619:Tacrine; C052075:thioperamide