Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells.
Helicobacter pylori is a microbial pathogen that colonises the stomach of more than half of the world's human population. H. pylori infection can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. A prominent feature of H. pylori is the presence of a pathogenicity island (PAI) which encodes a type IV secretion system (T4SS). This review focuses on the processes of how H. pylori induces PAI-dependent epithelial cell signalling that might be of importance in gastric inflammation and the pathogenesis of neoplasia.
Naumann
Michael
M
Institute of Experimental Internal Medicine, Medical Faculty, Otto-von-Guericke University, D-39120 Magdeburg, Germany. naumann@medizin.uni-magdeburg.de
D000942:Antigens, Bacterial / Q000502:physiology; D001426:Bacterial Proteins / Q000502:physiology; D002465:Cell Movement; D004847:Epithelial Cells / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology; D005756:Gastritis / Q000382:microbiology / Q000503:physiopathology; D044404:Genomic Islands / Q000235:genetics*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D021381:Protein Transport; D012306:Risk; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000382:microbiology; D037521:Virulence Factors / Q000502:physiology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori