title: [Stiff-person syndrome--two Hungarian cases and review of the literature].
abstract: The stiff-man syndrome is a rare neurological disorder characterized by progressive stiffness of the axial muscles and co-contraction of agonist and antagonist muscles sometimes accompanied by involuntary sudden muscle spasms. The disease is thought to be caused by immunological changes leading to a GABA transmission disturbance, but the precise pathogenesis is not clear. Two Hungarian cases are presented in this article accompanied by a review of the literature. The aim of the paper is to call the attention on this presumably underdiagnosed disease. The diagnostic laboratory tests of the disease are available in Hungary.
authors.affiliation: Debreceni Egyetem, Orvos-és Egészségtudományi Centrum, Neurológiai Klinika, Debrecen. alengyel@jaguar.dote.hu
authors.forename: András
authors.initials: A
authors.lastname: Lengyel
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lakos
authors.forename: Sándor
authors.initials: S
authors.lastname: Sipka
authors.forename: Katalin
authors.initials: K
authors.lastname: Hegedus
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D016750:Stiff-Person Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy