[Expressions of RhoC, CD44v6 and ICAM-1 in human gastric cancer and its clinicopathological significance].
OBJECTIVE
To investigate the expressions of RhoC, CD44v6 and ICAM-1 in gastric cancer and their correlations.


METHODS
SABC immunohistochemistry was used to detect the expressions of RhoC, CD44v6 and ICAM-1 in the specimens from 40 cases with gastric cancer. Their correlations were reviewed by clinicopathological data.


RESULTS
The expression of RhoC, CD44v6 and ICAM-1 were not correlated with tumor differentiation and invasion depth (P> 0.05), but significantly correlated with lymph metastasis and pTNM stage (P< 0.05). There was a significant correlation between the expression of RhoC and the expression of CD44v6 or ICAM-1 (r=0.355, P=0.006; r=0.354, P=0.003) respectively. If RhoC was positive-expressed, and either of CD44v6 or ICAM-1 was positive-expressed, the sensitivity and the specificity for predicting the lymphatic metastasis was 93.75%, 62.5% respectively.


CONCLUSIONS
The positive expressions of RhoC, CD44v6 and ICAM-1 are useful biological markers for predicting the metastatic potential of gastric cancer. The combined detection of three markers is a useful method for predicting lymphatic metastasis of gastric cancer.
Zhao
Zeng-qiang
ZQ
Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.
Yu
Pei-wu
PW
Zhao
Yong-liang
YL
Shi
Yan
Y
D000328:Adult; D000368:Aged; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*; D000075024:rhoC GTP-Binding Protein
C112697:CD44v6 antigen; D018960:Hyaluronan Receptors; D018799:Intercellular Adhesion Molecule-1; C066690:RHOC protein, human; D020741:rho GTP-Binding Proteins; D000075024:rhoC GTP-Binding Protein