Parathyroid hormone is associated with decreased fat mass in young healthy women.
OBJECTIVE
To investigate the relationship of parathyroid hormone (PTH) with dietary calcium and changes in body composition.


METHODS
Cross-sectional and 1-year longitudinal trial.


METHODS
Normal-weight young women (age: 18-31), 155 subjects analyzed at baseline, and data for 41 subjects analyzed prospectively between baseline and 12 months.


METHODS
Levels of fasting serum calcium and PTH, intakes of calcium (3-day diet records), and total body weight and body composition (dual energy X-ray absorptiometry).


RESULTS
Baseline dietary calcium, regardless of whether unadjusted or adjusted for energy intake, did not predict baseline levels of fasting serum PTH. Change in dietary calcium also did not predict change in serum PTH. However, log PTH was significantly correlated with body fat mass (R = 0.27), but not lean mass at baseline (n = 155), independent of serum calcium (corrected R = 0.25). Further, 12-month changes (n = 41) in log PTH positively predicted the 12-month change in body weight (R = 0.32) and body fat (R = 0.32), but not lean mass even when controlled for age or change in serum calcium.


CONCLUSIONS
Fasting serum PTH was associated with increased fat mass, in both cross-sectional and prospective analysis. Thus, serum PTH may play a role in the regulation of body fat mass in young women.
Gunther
C W
CW
Interdepartmental Nutrition Program, Purdue University, Department of Foods and Nutrition, West Lafayette, IN 47907, USA.
Legowski
P A
PA
Lyle
R M
RM
Weaver
C M
CM
McCabe
L D
LD
McCabe
G P
GP
Peacock
M
M
Teegarden
D
D
D015502:Absorptiometry, Photon / Q000379:methods; D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D001823:Body Composition; D001835:Body Weight / Q000502:physiology; D002118:Calcium / Q000097:blood; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood*; D011446:Prospective Studies
D002136:Calcium, Dietary; C470125:PTH protein, human; D010281:Parathyroid Hormone; D002118:Calcium