title: Genetics of fibromyalgia.
abstract: The pathogenesis of fibromyalgia (FM) and related conditions is not entirely understood. Recent evidence suggests that these syndromes may share heritable pathophysiologic features. Familial studies suggest that genetic and familial factors may play a role in the etiopathogenesis of these conditions. There is evidence that polymorphisms of genes in the serotoninergic and catecholaminergic systems are linked to the pathophysiology of FM and related conditions and are associated with personality traits. The precise role of genetic factors in the etiopathology of FM remains unknown, but it is likely that several genes are operating together to initiate this syndrome. Larger longitudinal studies are needed to better clarify the role of genetics in the development of FM.
authors.affiliation: Department of Medicine H, Soroka Medical Center, P.O. Box 151, Beer Sheva 84101, Israel. dbuskila@bgumail.bgu.ac.il
authors.forename: Dan
authors.initials: D
authors.lastname: Buskila
authors.forename: Lily
authors.initials: L
authors.lastname: Neumann
mesh_terms: D005356:Fibromyalgia / Q000235:genetics*; D006801:Humans; D019964:Mood Disorders / Q000235:genetics; D018377:Neurotransmitter Agents; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D018377:Neurotransmitter Agents