title: The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia.
abstract: The zinc finger and DHHC domain-containing protein 8 (ZDHHC8) gene is located on chromosome 22q11, which several genome scans have provided repeated evidence for a significant linkage with bipolar disorder (BPD) and schizophrenia. A recent study revealed that a single nucleotide polymorphism (SNP), rs175174, which has potential effects on splicing, in intron 4 of the ZDHHC8 gene is associated with susceptibility to patients with schizophrenia in US and South Africa. We examined three SNPs of the ZDHHC8 gene, including rs175174, by case-control association in Japanese patients with BPD (N=172) and controls (N=298) or patients with schizophrenia (N=407) and controls (N=497). No significant association with BPD or schizophrenia was observed. After stratification by subcategories, bipolar I and II of BPD, and paranoid and disorganized types of schizophrenia, no significant association was found, nor was a significant association with either disorder found after dividing by gender. These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata-cho 2-5-1, Okayama 700-8558, Japan.
authors.forename: Kyohei
authors.initials: K
authors.lastname: Otani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Morita
authors.forename: Makiko
authors.initials: M
authors.lastname: Kishimoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Morio
authors.forename: Naohiko
authors.initials: N
authors.lastname: Uchida
authors.forename: Akira
authors.initials: A
authors.lastname: Nomura
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000217:Acyltransferases / Q000235:genetics*; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors
chemical_list: D008565:Membrane Proteins; D000217:Acyltransferases; C488097:ZDHHC8 protein, human