title: Disintegration of Staphylococcus epidermidis biofilms under glucose-limiting conditions depends on the activity of the alternative sigma factor sigmaB.
abstract: To evaluate the role of the polysaccharide intercellular adhesin as an energy-storage molecule, we investigated the effect of nutrient limitation on S. epidermidis biofilms. The stability of established biofilms depends on sigma(B) activity; however, the slow decay of biofilms under conditions of nutrient limitation reveal its use as an energy-storage molecule to be unlikely.
authors.affiliation: Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin I, Institut für Infektionsmedizin, Martinistrasse 52, D-20246 Hamburg, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Jäger
authors.forename: Dietrich
authors.initials: D
authors.lastname: Mack
authors.forename: Holger
authors.initials: H
authors.lastname: Rohde
authors.forename: Matthias A
authors.initials: MA
authors.lastname: Horstkotte
authors.forename: Johannes K-M
authors.initials: JK
authors.lastname: Knobloch
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000378:metabolism; D006801:Humans; D009154:Mutation; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism; D012808:Sigma Factor / Q000378:metabolism*; D013212:Staphylococcus epidermidis / Q000254:growth & development*
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; C080358:RsbW protein, bacteria; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D010744:Phosphoric Monoester Hydrolases; C091162:RsbU protein, Bacillus subtilis; D005947:Glucose