Behavioral effects on rats of high strength magnetic fields generated by a resistive electromagnet.
It has been reported previously that exposure to static high magnetic fields of 7 T or above in superconducting magnets has behavioral effects on rats. In particular, magnetic field exposure acutely but transiently suppressed rearing and induced walking in tight circles; the direction of circular locomotion was dependent on the rats' orientation within the magnet. Furthermore, when magnet exposure was paired with consumption of a palatable, novel solution, rats acquired a persistent taste aversion. In order to confirm these results under more controlled conditions, we exposed rats to static magnetic fields of 4 to 19.4 T in a 189 mm bore, 20 T resistive magnet. By using a resistive magnet, field strengths could be arbitrary varied from -19.4 to 19.4 T within the same bore. Rearing was suppressed after exposure to 4 T and above; circling was observed after 7 T and above. Conditioned taste aversion was acquired after 14 T and above. The effects of the magnetic fields were dependent on orientation. Exposure to +14 T induced counter-clockwise circling, while exposure to -14 T induced clockwise circling. Exposure with the rostral-caudal axis of the rat perpendicular to the magnetic field produced an attenuated behavioral response compared to exposure with the rostral-caudal axis parallel to the field. These results in a single resistive magnet confirm and extend our earlier findings using multiple superconducting magnets. They demonstrate that the behavioral effects of exposure within large magnets are dependent on the magnetic field, and not on non-magnetic properties of the machinery. Finally, the effects of exposure to 4 T are clinically relevant, as 4 T magnetic fields are commonly used in functional MRI assays.
Houpt
Thomas A
TA
Department of Biological Science, The Florida State University, Tallahassee, FL 32306-4340, USA. houpt@neuro.fsu.edu
Pittman
David W
DW
Riccardi
Christina
C
Cassell
Jennifer A
JA
Lockwood
Denesa R
DR
Barranco
Jan M
JM
Kwon
Bumsup
B
Smith
James C
JC
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000528:radiation effects; D001522:Behavior, Animal / Q000528:radiation effects*; D003213:Conditioning, Psychological / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena / Q000295:instrumentation / Q000379:methods*; D008297:Male; D009043:Motor Activity / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000528:radiation effects; D013997:Time Factors