Diphenylprolinol methyl ether: a highly enantioselective catalyst for Michael addition of aldehydes to simple enones.
[reaction: see text] Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been typical in this arena.
Chi
Yonggui
Y
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.
Gellman
Samuel H
SH