title: The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC).
abstract: OBJECTIVE
  To determine the efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC).
  
  
  METHODS
  A retrospective multi-institutional investigation was performed to identify surgically staged patients with Stage I UPSC who were (1) treated after surgery with 3-6 courses of platinum-based chemotherapy without radiation from 1990-2003, and (2) followed for a minimum of 12 months, or until recurrence.
  
  
  RESULTS
  Six patients (IA-2, IB-3, IC-1) were treated with carboplatin (AUC 6) or cisplatin (50 mg/m2) alone. One patient recurred to the vagina, was treated with chemo-radiation, and is alive and well at 122 months. One patient recurred to the lung, liver, and brain, and died of disease at 24 months. The remaining 4 patients are alive with no evidence of disease 15-124 months (mean 62 months) after treatment. Two patients (IB-1, IC-1) were treated with cisplatin (50 mg/m2) and cyclophosphamide (1000 mg/m2), and both are alive and well with no evidence of disease 75 and 168 months after treatment. Twenty-one patients (IA-5, IB-13, IC-3) were treated with a combination of carboplatin (AUC 6) and paclitaxel (135 mg/m2-175 mg/m2). One patient recurred to the vagina after 3 cycles of carboplatin/paclitaxel, and was treated with chemo-radiation. She is now without evidence of disease 10 months after treatment. At present, all 21 patients with Stage I UPSC treated following surgical staging with carboplatin/paclitaxel chemotherapy are alive and well with no evidence of disease 10-138 months (mean 41 months) after treatment.
  
  
  CONCLUSIONS
  Combination carboplatin/paclitaxel chemotherapy following surgery is effective in the treatment of Stage I UPSC.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Dietrich
authors.forename: S C
authors.initials: SC
authors.lastname: Modesitt
authors.forename: P D
authors.initials: PD
authors.lastname: DePriest
authors.forename: F R
authors.initials: FR
authors.lastname: Ueland
authors.forename: J
authors.initials: J
authors.lastname: Wilder
authors.forename: M B
authors.initials: MB
authors.lastname: Reedy
authors.forename: E J
authors.initials: EJ
authors.lastname: Pavlik
authors.forename: R
authors.initials: R
authors.lastname: Kryscio
authors.forename: M
authors.initials: M
authors.lastname: Cibull
authors.forename: J
authors.initials: J
authors.lastname: Giesler
authors.forename: K
authors.initials: K
authors.lastname: Manahan
authors.forename: W
authors.initials: W
authors.lastname: Huh
authors.forename: D
authors.initials: D
authors.lastname: Cohn
authors.forename: M
authors.initials: M
authors.lastname: Powell
authors.forename: B
authors.initials: B
authors.lastname: Slomovitz
authors.forename: R V
authors.initials: RV
authors.lastname: Higgins
authors.forename: W
authors.initials: W
authors.lastname: Merritt
authors.forename: J
authors.initials: J
authors.lastname: Hunter
authors.forename: L
authors.initials: L
authors.lastname: Puls
authors.forename: P
authors.initials: P
authors.lastname: Gehrig
authors.forename: J R
authors.initials: JR
authors.lastname: van Nagell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D002291:Carcinoma, Papillary / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D018284:Cystadenocarcinoma, Serous / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D003520:Cyclophosphamide; D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin