title: Change in bacterial aetiology of peritoneal dialysis-related peritonitis over 10 years: experience from a centre in South-East Asia.
abstract: This study reviewed 1787 episodes of peritoneal dialysis (PD)-related peritonitis in 544 patients between 1994 and 2003. The overall rate of peritonitis was 0.68 episodes/year of PD, but decreased from 1.10 to 0.46 episodes/year between 1994 and 2003. The incidence of peritonitis caused by coagulase-negative staphylococci declined between 1994 and 1998 from 0.21 to 0.06 episodes/year of PD, coinciding with a reduction in the use of spike PD sets. There was a 60.1% response rate to antibiotics throughout the period, but the percentage of cases that required modification of the initial empirical antibiotic regimen rose from 13.6% to 58.7%, indicating that treatment should be individualised.
authors.affiliation: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. ccszeto@cuhk.edu.hk
authors.forename: C-C
authors.initials: CC
authors.lastname: Szeto
authors.forename: C-B
authors.initials: CB
authors.lastname: Leung
authors.forename: K-M
authors.initials: KM
authors.lastname: Chow
authors.forename: B C-H
authors.initials: BC
authors.lastname: Kwan
authors.forename: M-C
authors.initials: MC
authors.lastname: Law
authors.forename: A Y-M
authors.initials: AY
authors.lastname: Wang
authors.forename: S-F
authors.initials: SF
authors.lastname: Lui
authors.forename: P K-T
authors.initials: PK
authors.lastname: Li
mesh_terms: D001210:Asia, Southeastern; D006801:Humans; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010538:Peritonitis / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000209:etiology*; D013210:Staphylococcus / Q000201:enzymology / Q000302:isolation & purification