title: [A case of primary hepatic lymphoma mimicking hepatitis].
abstract: We report here on a case of non-Hodgkin's lymphoma in which liver involvement was the predominant clinical manifestation. A healthy 44-year-old man presented with upper abdominal pain, hepatosplenomegaly, thrombocytopenia, elevated AST, ALT and bilirubin, and marked elevation of lactate dehydrogenase and alkaline phosphatase. The abdominal CT scan showed only diffuse hepatosplenomegaly and uneven contrast enhancement of the spleen without any definite mass of the liver and spleen. US-guided aspiration biopsy of liver and the histologic examination confirmed a diagnosis of non-Hodgkin's lymphoma, the diffuse large B cell type. Bone marrow biopsy showed the infiltration of malignant lymphoma cells. PET-CT showed an increased FDG uptake of the liver, spleen and long bones. The patient was treated with combination regimen of cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy. Even in the absence of a mass lesion or lymphadenopathy, primary hepatic or hepatosplenic lymphoma should be considered in differential diagnosis of hepatitis or liver cirrhosis, especially for patients with diffuse hepatosplenomegaly and markedly elevated LDH.
authors.affiliation: Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
authors.forename: Kyung Mi
authors.initials: KM
authors.lastname: Kang
authors.forename: Woo Chul
authors.initials: WC
authors.lastname: Chung
authors.forename: Kang Moon
authors.initials: KM
authors.lastname: Lee
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Hur
authors.forename: Jong Myoung
authors.initials: JM
authors.lastname: Nah
authors.forename: Gee Hee
authors.initials: GH
authors.lastname: Kim
authors.forename: Ju Yeal
authors.initials: JY
authors.lastname: Back
authors.forename: Sung Kyoung
authors.initials: SK
authors.lastname: Kim
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Yang
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Choi
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000175:diagnosis*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology; D008297:Male