[Effects of naoyian granule on the expression of IL-6 mRNA and protein in the experimental intracerebral hemorrhagic brain in rats].
OBJECTIVE
To explore the protective mechanisms of the traditional Chinese medicine complex Naoyian granule (NYA) on intracerebral hemorrhagic (ICH).


METHODS
ICH rat models were established by stereotaxically injecting 0.4 U type VII collagenase into the right globus pallidus (GP), the expression of IL-6mRNA and protein were investigated by in situ hybridization and Western blotting.


RESULTS
In the NYA group the IL-6 mRNA level was higher than that of the model group on 4 - 7 d and the IL-6 protein level was remarkably higher than that of the model group on 6 h - 7 d after ICH injury (P <0.01).


CONCLUSIONS
Up-regulating the expression of IL-6 protein, and stabilizing the increasing expression of IL-6 mRNA and protein may be the protective mechanisms of NYA.
Xiao
Lan
L
Institute of Combined Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Li
Xing-Qun
XQ
Zhang
Hua-Xian
HX
D000818:Animals; D001921:Brain / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000188:drug therapy / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation
D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D012333:RNA, Messenger