title: [Abnormal glycemic metabolism in essential hypertension. Role of the an oral glucose tolerance test].
abstract: OBJECTIVE
  There is a high prevalence of diabetes in essential hypertensive patients, hence increasing the cardiovascular risk of these subjects. Our aim was to test the importance of a routine assessment of an oral glucose tolerance test (OGTT) in a sample of recently diagnosed essential hypertensives.
  
  
  METHODS
  We studied 270 recently diagnosed untreated hypertensives (56% males). We measured fasting lipids and plasma glucose and insulin at baseline and after OGTT.
  
  
  RESULTS
  38.5% of the studied subjects had any abnormality of glucose metabolism, glucose intolerance (22.2%) and type 2 diabetes (12.2%) being the most common. An impaired fasting glucose was present in 4.1% of subjects. Patients with intolerance or type 2 diabetes had a worse plasma lipid profile, and those with impaired fasting glucose, a higher HOMA index.
  
  
  CONCLUSIONS
  The high incidence of glucidic abnormalities found in hypertensive patients signals a need to perform an OGTT test in them. This can lead to the implementation of strategies aimed at halting vascular impairment in hypertensives with type 2 diabetes and delay the development of type 2 diabetes in patients with glucose intolerance.
authors.affiliation: Unidad Clínico Experimental de Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Stiefel
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Miranda
authors.forename: Ovidio
authors.initials: O
authors.lastname: Muñiz
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Nieto
authors.forename: Luis
authors.initials: L
authors.lastname: Jiménez
authors.forename: José
authors.initials: J
authors.lastname: Villar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000517:prevention & control; D005260:Female; D018149:Glucose Intolerance / Q000150:complications* / Q000175:diagnosis; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose