Genetic analysis of the TOR pathway in Aspergillus nidulans.
We identified five genes encoding components of the TOR signaling pathway within Aspergillus nidulans. Unlike the situation in Saccharomyces cerevisiae, there is only a single Tor kinase, as in plant and animal systems, and mutant phenotypes suggest that the TOR pathway plays only a minor role in regulating nitrogen metabolism.
Fitzgibbon
Gregory J
GJ
The University of Liverpool, School of Biological Sciences, The Biosciences Building, Crown Street, Liverpool L69 7ZB, United Kingdom.
Morozov
Igor Y
IY
Jones
Meriel G
MG
Caddick
Mark X
MX
D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000494:pharmacology; D001233:Aspergillus nidulans / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D025141:Drug Resistance, Fungal; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D009584:Nitrogen / Q000378:metabolism; D010641:Phenotype; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases
D000935:Antifungal Agents; D005656:Fungal Proteins; D012333:RNA, Messenger; D011494:Protein Kinases; D058570:TOR Serine-Threonine Kinases; D009584:Nitrogen; D020123:Sirolimus