[Occurrence of autoimmune chronic hepatitis in siblings].
BACKGROUND
Autoimmune hepatitis is a chronic inflamatory disease of the liver of unknown etiology, characterized by the loss of tolerance against hepatic tissue, leading to the destruction of hepatic parenchyma. It predominantly affects females, and rarely occurs in the same family.


METHODS
In this paper we presented brother and sister with autoimmune hepatitis according to the criteria of the International Autoimmune Hepatitis Group.


CONCLUSIONS
Because of a possible genetic predisposition to autoimmune hepatitis, the occurrence of the disease in a family member suggested the need to examine other family members.
Nozić
Darko
D
Vojnomedicinska akademija, Klinika za infektivne i tropske bolesti, Beograd, Srbija i Crna Gora.
Dimitrijević
Jovan
J
Knezević-Usaj
Slavica
S
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D019693:Hepatitis, Autoimmune / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology