title: Significance of the "halo" sign for progression and regression of nodular pulmonary amyloidosis: radiographic-pathological correlation (2005:6b).
abstract: We describe a case of a systemic amyloidosis of kappa-AL type, presenting at CT as focal lung parenchymal nodules or areas of consolidation with or without a halo,showing different sizes and morphologic kinetics at follow-up. Lesions accompanied by a halo revealed faster progression and earlier response to chemotherapy with almost complete resolution after high dose therapy with a cytostatic alkylating agent(Melphalan) and autologous peripheral stem cell transplantation than their counterparts without a halo. Amyloid deposition was histologically confirmed, and severe inflammatory activity was found in and at the margins of the amyloidomas, the latter correlating in CT with the halo sign. In our case, this sign had a high prediction for growth kinetics and response to therapy of pulmonary amyloid.
authors.affiliation: Department of Diagnostic Radiology, Eberhard-Karls-University, Tübingen, Germany. mshorger@med.uni-tuebingen.de
authors.forename: Marius
authors.initials: M
authors.lastname: Horger
authors.forename: Claudia
authors.initials: C
authors.lastname: Lengerke
authors.forename: Christina
authors.initials: C
authors.lastname: Pfannenberg
authors.forename: Manfred
authors.initials: M
authors.lastname: Wehrmann
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
authors.forename: Stefan
authors.initials: S
authors.lastname: Knop
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000473:pathology; D018450:Disease Progression; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000682:Amyloid; D007145:Immunoglobulin kappa-Chains; D019653:Myeloablative Agonists; D008558:Melphalan