title: The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage.
abstract: Thrombophilia has been described to be involved in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a C-->T polymorphism at nucleotide 46 in the 5'-untranslated region of the coagulation factor XII (FXII) gene. Two hundred and twelve women with a history of IRM and 149 healthy controls were tested by a mutagenically separated polymerase chain reaction assay (MS PCR). Allele and genotype frequencies were not significantly different between the study and the control groups. Our data suggest that the FXII gene is not a candidate gene for this condition.
authors.affiliation: Department of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria.
authors.forename: Katharina
authors.initials: K
authors.lastname: Walch
authors.forename: Eva-Katrin
authors.initials: EK
authors.lastname: Riener
authors.forename: Clemens B
authors.initials: CB
authors.lastname: Tempfer
authors.forename: Georg
authors.initials: G
authors.lastname: Endler
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Huber
authors.forename: Gertrud
authors.initials: G
authors.lastname: Unfried
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005174:Factor XII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D010298:Parity; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy
chemical_list: D005174:Factor XII