title: [Hepatoprotective effects of Gentiana scabra on the acute liver injuries in mice].
abstract: OBJECTIVE
  To study the hepatoprotective effect of the aerial parts and the roots of G. scabra on cute liver injury models.
  
  
  METHODS
  Acute liver injury models were induced by CCl4, TAA and D-GlanN in mice, and the levels of serum enzyme ALT, AST and AKP on acute liver injury mice with extracts of theaerial parts and the roots of G. scabra were determined.
  
  
  RESULTS
  Different dosages of theaerial part extract could significantly reduce the levels of serum enzyme ALT, AST and AKP (P < 0.05) on CCl4 and TAA model mice, but the serum enzymes reduction of D-GlanN model mice was not remarkably.
  
  
  CONCLUSIONS
  The methanolic extracts of the aerial parts and the roots of G. scabra both have certain hepatoprotective effects on acute liver injury models, and so the aerial parts of G. scabra can be used as the succedaneumm of G. scabra roots.
authors.affiliation: Pharmaceutical College, Harbin University of Commerce, Harbin 150076, China.
authors.forename: Wei-Xin
authors.initials: WX
authors.lastname: Jiang
authors.forename: Bao-Yu
authors.initials: BY
authors.lastname: Xue
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005688:Galactosamine; D030012:Gentiana / Q000737:chemistry; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013853:Thioacetamide
chemical_list: D004365:Drugs, Chinese Herbal; D013853:Thioacetamide; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase