The proximal convoluted tubule of rats' nephron after experimental administration of gentamicin.
The rats in this experiment received gentamicin in intraperitoneal injections in a dose ten times bigger than therapeutical. After ten days of drug administration, in the cells of proximal convoluted tubules of kidney there were observed the dilution of cytoplasm of various intensity, increases in amount and size of lysosomes, widening of endoplasmic reticulum tubules and swelling of mitochondria. The microscopic and ultrastructural pictures, after three weeks' break in gentamicin administration, showed fast regeneration of renal tubules. A large diversity of intensification of changes in particular individuals suggested individual reaction to gentamicin nephrotoxicity.
Kifer-Wysocka
Ewa
E
Department and Institute of Histology and Embryology with the Laboratory for Experimental Cytology, Skubiszewski Medical University of Lublin.
Romanowska-Sarlej
Jadwiga
J
Karwan
Agnieszka
A
Matysiak
Włodzimierz
W
Lis-Sochocka
Marta
M
D000818:Animals; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009399:Nephrons / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D051381:Rats
D005839:Gentamicins