title: Colposcopic and histopathologic evaluation of women participating in population-based screening for human papillomavirus deoxyribonucleic acid persistence.
abstract: OBJECTIVE
  Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence.
  
  
  METHODS
  A total of 12 527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer 5+/6+ polymerase chain reaction and subsequent typing. Human papillomavirus deoxyribonucleic acid-positive women with a normal Papanicolaou smear (n=341) and an equal number from the control group were human papillomavirus tested on average 19 months later. One hundred nineteen women with type-specific human papillomavirus persistence and 111 controls were referred to colposcopy, and 84.8% attended.
  
  
  RESULTS
  Histopathology from colposcopically directed biopsies confirmed cervical intraepithelial neoplasia grade 2 or 3 in 28 of 100 of the women with human papillomavirus deoxyribonucleic acid persistence and in 2 of 95 among controls.
  
  
  CONCLUSIONS
  Among women with normal Papanicolaou smear attending population-based screening, the positive predictive value of human papillomavirus deoxyribonucleic acid persistence for detection of biopsy-confirmed cervical intraepithelial neoplasia 2 or 3 was 29%.
authors.affiliation: Department of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden. kristina.elfgren@karolinska.se
authors.forename: Kristina
authors.initials: K
authors.lastname: Elfgren
authors.forename: Eva
authors.initials: E
authors.lastname: Rylander
authors.forename: Thomas
authors.initials: T
authors.lastname: Rådberg
authors.forename: Björn
authors.initials: B
authors.lastname: Strander
authors.forename: Anders
authors.initials: A
authors.lastname: Strand
authors.forename: Kirsti
authors.initials: K
authors.lastname: Paajanen
authors.forename: Inga
authors.initials: I
authors.lastname: Sjöberg
authors.forename: Walter
authors.initials: W
authors.lastname: Ryd
authors.forename: Ilvars
authors.initials: I
authors.lastname: Silins
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
mesh_terms: D000328:Adult; D000465:Algorithms; D003127:Colposcopy; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000235:genetics*; D011237:Predictive Value of Tests; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology
chemical_list: D004279:DNA, Viral