Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury.
Neurons in the hilus of the dentate gyrus are lost following a lateral fluid percussion injury. Environmental enrichment is known to increase neurogenesis in the dentate in intact rats, suggesting that it might also do so following fluid percussion injury, and potentially provide replacements for lost neurons. We report that 1 h of daily environmental enrichment for 3 weeks increased the number of progenitor cells in the dentate following fluid percussion injury, but only on the ipsilesional side. In the dentate granule cell layer, but not the hilus, most progenitors had a neuronal phenotype. The rate of on going cell proliferation was similar across groups. Collectively, these results suggest that the beneficial effects of environmental enrichment on behavioral recovery following FP injury are not attributable to neuronal replacement in the hilus but may be related to increased neurogenesis in the granule cell layer.
Gaulke
Lindsey J
LJ
Department of Rehabilitation Medicine, University of Washington, Seattle, WA 98195, USA.
Horner
Philip J
PJ
Fink
Andrew J
AJ
McNamara
Courtney L
CL
Hicks
Ramona R
RR
D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000473:pathology* / Q000534:rehabilitation; D002452:Cell Count; D002455:Cell Division; D002470:Cell Survival; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D003399:Craniotomy; D018891:Dentate Gyrus / Q000473:pathology*; D004777:Environment; D005106:Exploratory Behavior; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D018613:Microscopy, Confocal; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D010812:Physical Stimulation; D010988:Play and Playthings; D051381:Rats; D017207:Rats, Sprague-Dawley; D013037:Spatial Behavior; D013234:Stem Cells / Q000473:pathology*; D014949:Wounds, Nonpenetrating / Q000150:complications / Q000473:pathology* / Q000534:rehabilitation
D019394:Ki-67 Antigen