Cavitation detection during shock-wave lithotripsy.
A system was built to detect cavitation in pig kidney during shock-wave lithotripsy (SWL) with a Dornier HM3 lithotripter. Active detection using echo on B-mode ultrasound, and passive cavitation detection using coincident signals on confocal orthogonal receivers, were used to interrogate the renal collecting system (urine) and the kidney parenchyma (tissue). Cavitation was detected in urine immediately upon shock-wave (SW) administration in urine or urine plus X-ray contrast agent but, in native tissue, cavitation required hundreds of SWs to initiate. Localization of cavitation was confirmed by fluoroscopy, sonography and by thermally marking the kidney using the passive cavitation detection receivers as high-intensity focused ultrasound sources. Cavitation collapse times in tissue and native urine were about the same, but less than in urine after injection of X-ray contrast agent. The finding that cavitation occurs in kidney tissue is a critical step toward determining the mechanisms of tissue injury in SWL.
Bailey
Michael R
MR
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, WA 98105, USA. bailey@apl.washington.edu
Pishchalnikov
Yuri A
YA
Sapozhnikov
Oleg A
OA
Cleveland
Robin O
RO
McAteer
James A
JA
Miller
Nathan A
NA
Pishchalnikova
Irina V
IV
Connors
Bret A
BA
Crum
Lawrence A
LA
Evan
Andrew P
AP
D000818:Animals; D007668:Kidney / Q000000981:diagnostic imaging / Q000293:injuries*; D008096:Lithotripsy / Q000009:adverse effects*; D023421:Models, Animal; D013010:Sonication; D013552:Swine; D014159:Transducers; D014463:Ultrasonography