title: Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b.
abstract: Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.
authors.affiliation: Department of Microbiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fukasawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kawamura
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Uchiyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Taijin
authors.initials: T
authors.lastname: Kaku
authors.forename: Takanari
authors.initials: T
authors.lastname: Tominaga
authors.forename: Takamasa
authors.initials: T
authors.lastname: Nomura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichiyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ezaki
authors.forename: Masao
authors.initials: M
authors.lastname: Mitsuyama
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology*; D014376:Tuberculosis / Q000276:immunology
chemical_list: D016207:Cytokines; D013307:Streptomycin