title: [Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer].
abstract: OBJECTIVE
  UDP-glucuronosyltransferase 1A7 (UGT1A7) plays an important role in detoxification through catalyzing combination of glucuronic acid and tobacco carcinogens, including benzo [alpha] pyrene, nitrosamine, and heterocyclic amine PhIP, therefore, inactivates the carcinogens. This study was to examine the correlation of polymorphisms of UGT1A7 gene to genetic susceptibility of lung cancer.
  
  
  METHODS
  Polymorphisms of UGT1A7 gene at 12-131 and 208 sites in peripheral lymph cells of 312 patients and 317 age- and sex-matched controls were detected by polymerase chain reaction-denaturized high performance liquid chromatography (PCR-DHPLC) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP); the correlation of these polymorphisms to genetic susceptibility of lung cancer was analyzed.
  
  
  RESULTS
  Compared with the UGT1A7*1/*1 genotype carriers, the UGT1A7*3/*1 genotype carriers had a 1.80-fold increased risk of lung adenocarcinoma [adjusted odds ratio (OR), 1.80; 95% confidence interval (CI), 1.03-3.12], the UGT1A7*3 genotype carriers had a 1.59-fold increased risk of lung adenocarcinoma (adjusted OR, 1.59; 95% CI, 0.96-2.63). The UGT1A7 polymorphisms had no correlation with risk of lung squamous cell carcinoma.
  
  
  CONCLUSIONS
  UGT1A7 gene polymorphisms may increase the genetic susceptibility of lung adenocarcinoma in Chinese.
authors.affiliation: Department of Thoracic Surgery, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
authors.forename: Fei-Yue
authors.initials: FY
authors.lastname: Feng
authors.forename: Gang
authors.initials: G
authors.lastname: Liang
authors.forename: Wen-Fu
authors.initials: WF
authors.lastname: Lu
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Miao
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Yu
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Zhou
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.forename: Bin
authors.initials: B
authors.lastname: Kang
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Kai-Feng
authors.initials: KF
authors.lastname: Pan
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
authors.forename: Dong-Xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014453:Glucuronosyltransferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D014453:Glucuronosyltransferase; C107611:UDP-glucuronosyltransferase, UGT1A7