[Severe hyperkalemia associated to the use of losartan and spironolactone: case report].
Hyperkalemia is a complications of the use of angiotensin converting enzyme inhibitors, angiotensin receptor antagonists and aldosterone antagonists. These drugs are commonly used for the treatment of hypertension and cardiac failure. We report a 84 year-old female treated with losartan 50 mg/day and spironolactone 25 mg/day that presented with a hyperkalemia of 8.4 mEq/l and bradicardia, drowsiness and respiratory depression. She required hemodialysis and ventilatory assistance. She was discharged in good conditions five days after admission.
Kauffmann
Ronald
R
Unidad de Cuidados Coronarios e Intermedio Coronario, Clínica Las Condes, Santiago, Chile. roka@clinicalascondes.cl
Orozco
Rodrigo
R
Venegas
Juan Carlos
JC
D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D006973:Hypertension / Q000188:drug therapy; D019808:Losartan / Q000009:adverse effects*; D012720:Severity of Illness Index; D013148:Spironolactone / Q000009:adverse effects*
D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D013148:Spironolactone; D019808:Losartan