title: [Analysis of prognostic factors in gastrointestinal stromal tumors of the small intestine].
abstract: OBJECTIVE
  To explore the prognostic factors in patients with gastrointestinal stromal tumors of the small intestine.
  
  
  METHODS
  Tumor slides stained with hematoxylin and eosin from these patients were reviewed. Two histomorphologically representative areas were identified and arrayed on a tissue microarray. Immunohistochemistry staining were performed using antibodies to detect the expression of c-kit protein (CD117), CD34, smooth muscle actin, desmin, S-100, Ki-67, P53 and bcl-2 protein. The relationship between clinicopathologic features and prognosis was analyzed by univariate analysis.
  
  
  RESULTS
  The 1-, 3-, 5-year survival rate of 58 such patients were 98.3%, 69.7%, and 50.9% respectively. The prognosis was related with tumor size and gender by univariate analysis (P< 0.05).
  
  
  CONCLUSIONS
  More attention should be paid to the male patients with small intestine stromal tumors,especially those with tumors size> 5 cm, because those tumors are more likely to metastasize than smaller tumors (< or = 5 cm).
authors.affiliation: Department of Abdominal Surgery, Cancer Institute (Hospital), Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, China. bai5151@yahoo.com.cn
authors.forename: Yue-kui
authors.initials: YK
authors.lastname: Bai
authors.forename: Yong-fu
authors.initials: YF
authors.lastname: Shao
authors.forename: Su-sheng
authors.initials: SS
authors.lastname: Shi
authors.forename: Yan-ning
authors.initials: YN
authors.lastname: Gao
authors.forename: Yun-tian
authors.initials: YT
authors.lastname: Sun
authors.forename: Yu-liang
authors.initials: YL
authors.lastname: Wan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis