Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: synthesis, characterization, and DNA cleavage.
Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and 1H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II).
Peng
Wei
W
Department of Chemistry, Key Laboratory of Green Chemistry and Technology ,Ministry of Education, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China.
Liu
Pei-Yan
PY
Jiang
Ning
N
Lin
Hong-Hui
HH
Zhang
Guo-Lin
GL
Liu
Yi
Y
Yu
Xiao-Qi
XQ
D004247:DNA / Q000737:chemistry*; D006868:Hydrolysis; D007202:Indicators and Reagents; D047028:Macrocyclic Compounds / Q000138:chemical synthesis*; D008958:Models, Molecular; D010957:Plasmids / Q000737:chemistry; D011073:Polyamines / Q000138:chemical synthesis*; D015032:Zinc
D007202:Indicators and Reagents; D047028:Macrocyclic Compounds; D011073:Polyamines; D004247:DNA; D015032:Zinc