title: Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines.
abstract: [reaction: see text] An expedient synthesis of diverse 2-amino-4-heteroarylpyrimidines via a 2-chloropyrimidine intermediate is described. A series of potentially biologically active analogues have been synthesized in two parallel steps to afford focused arrays.
authors.affiliation: Exploratory Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. bursavm@wyeth.com
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Bursavich
authors.forename: Sabrina
authors.initials: S
authors.lastname: Lombardi
authors.forename: Adam M
authors.initials: AM
authors.lastname: Gilbert
mesh_terms: D000586:Amination; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011743:Pyrimidines