Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics.
Benzo[d]isoselenazol-3-ones N-substituted with sterically hindered diamagnetic and paramagnetic five- or six-membered nitroxides or their precursors, including ring-opened diselenides, exhibit synergism in glutathione peroxidase (GPx) activity.
Kálai
Tamas
T
Institute of Organic and Medicinal Chemistry, University of Pécs, P. O. Box 99, H-7602, Pécs, Hungary.
Mugesh
Govindasamy
G
Roy
Gouriprasanna
G
Sies
Helmut
H
Berente
Zoltán
Z
Hideg
Kálmán
K
D000588:Amines / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism*; D018716:Molecular Mimicry; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000737:chemistry
D000588:Amines; D000975:Antioxidants; D016566:Organoselenium Compounds; D009569:Nitric Oxide; D005979:Glutathione Peroxidase