title: Traceless solid-phase synthesis of N1,N7-disubstituted purines.
abstract: A highly regioselective and traceless solid-phase route to N1,N7-disubstituted purines has been developed. Key steps in the reaction strategy involves (i) coupling of 6-chloropurine to the REM resin (Michael addition), (ii) oxidation, (iii) N1-alkylation, (iv) quaternization, and (v) product release through Hofmann elimination. A library of 15 N1,N7-disubstituted purines was synthesized.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Han
authors.initials: H
authors.lastname: Fu
authors.forename: Yulin
authors.initials: Y
authors.lastname: Lam
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D011687:Purines