title: Antioxidant activity of new ruthenium compounds.
abstract: Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl2(nic)4] where nic is 3-pyridinecarboxylic acid and trans-[RuCl2(i-nic)4] where i-nic is 4-pyridinecarboxylic acid by (i) evaluation of total antioxidant potential (TRAP); (ii) prevention of DNA damage induced by hydrogen peroxide using the alkaline comet assay; and (iii) the prevention of lipid peroxidation and cell death induced by iron in liver slices. Our results suggest that nic has stronger antioxidant potential when compared to the i-nic. Higher doses (above 200 microM) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1-10 microM).
authors.affiliation: Laboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
authors.forename: Marcos Marques da Silva
authors.initials: MM
authors.lastname: Paula
authors.forename: Claus Tröger
authors.initials: CT
authors.lastname: Pich
authors.forename: Fabrícia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Lilian Batista
authors.initials: LB
authors.lastname: Drei
authors.forename: Martina
authors.initials: M
authors.lastname: Rudnicki
authors.forename: Marcos Roberto
authors.initials: MR
authors.lastname: de Oliveira
authors.forename: José Cláudio Fonseca
authors.initials: JC
authors.lastname: Moreira
authors.forename: João Antônio Pegas
authors.initials: JA
authors.lastname: Henriques
authors.forename: César Vittorio
authors.initials: CV
authors.lastname: Franco
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal Pizzol
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D020552:Comet Assay; D004249:DNA Damage; D007539:Isonicotinic Acids / Q000494:pharmacology; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D009525:Niacin / Q000494:pharmacology; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D012428:Ruthenium / Q000494:pharmacology*; D017975:Ruthenium Compounds / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D007539:Isonicotinic Acids; D017975:Ruthenium Compounds; D009525:Niacin; D012428:Ruthenium