title: [The altered function of the epidermic desmosomes and its clinical repercusion (penphigus)].
abstract: Dermatology is mainly a speciality based on the macro and miscroscopic morphology. In the second half of the 20th century, the physiological and physiopathological knowledge have undergone a great change and shown a non-stop progress. The aim of this work is the physiopathology of the penphigus. This works starts with the description of the structure, molecular composition and function of the epidermic desmosomes, given that its alteration leads to the appearance of the illness.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Robledo Aguilar
mesh_terms: D000328:Adult; D000818:Animals; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D003896:Desmosomes / Q000378:metabolism / Q000502:physiology; D004817:Epidermis / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D010392:Pemphigus / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D003598:Cytoskeletal Proteins; D051180:Desmoplakins