title: Disseminated epitheloid hemangioendothelioma mimicking symptoms of systemic vasculitis.
abstract: BACKGROUND
  Epitheloid hemangioendothelioma is a rare malignant tumor which can involve bones, liver, lungs, kidneys, deep soft tissue, muscles, dermis, and central nervous system. Multifocal disease occurs in 10% of the cases. The clinical presentation results from occlusion of small blood vessels due to the disease itself or as a paraneoplastic syndrome.
  
  
  METHODS
  We present a patient with symptoms suggesting systemic vasculitis (ESR and CRP elevated, weight loss, arthralgia, livedoid rash, and skin ulcerations) who finally was diagnosed having a disseminated epitheloid hemangioendothelioma when PET scan revealed hypermetabolic multifocal skeletal and soft tissue lesions.
  
  
  CONCLUSIONS
  Diseases mimicking systemic vasculitis and the value of PET in this setting are discussed.
authors.affiliation: Department of Endocrinology, Metabolism, Clinical Chemistry and Vascular Medicine, University of Tübingen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Haap
authors.forename: Ina
authors.initials: I
authors.lastname: Kötter
authors.forename: Marius
authors.initials: M
authors.lastname: Horger
authors.forename: Claus
authors.initials: C
authors.lastname: Thamer
authors.forename: Manfred
authors.initials: M
authors.lastname: Wehrmann
authors.forename: Hans-U
authors.initials: HU
authors.lastname: Häring
authors.forename: Lothar
authors.initials: L
authors.lastname: Kanz
authors.forename: Jörg Thomas
authors.initials: JT
authors.lastname: Hartmann
mesh_terms: D000368:Aged; D001158:Arteries / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D001799:Blood Sedimentation; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D003937:Diagnosis, Differential; D018450:Disease Progression; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008218:Lymphocytosis / Q000473:pathology; D008297:Male; D009360:Neoplastic Cells, Circulating; D049268:Positron-Emission Tomography; D012867:Skin / Q000098:blood supply / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology; D040521:Subcutaneous Tissue / Q000098:blood supply / Q000473:pathology; D014657:Vasculitis / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D002097:C-Reactive Protein