Evolution of NAD biosynthetic enzymes.
Two research groups have solved crystal structures of nicotinic acid phosphoribosyltransferase (PRTase) and made the argument that PRTases in three distinct pathways of nicotinamide adenine dinucleotide (NAD) biosynthesis evolved from a common ancestor (Shin et al., 2005 and Chappie et al., 2005).
Brenner
Charles
C
Department of Genetics, Dartmouth Medical School,Lebanon, NH 03756, USA.
D019143:Evolution, Molecular; D009243:NAD / Q000096:biosynthesis*; D010430:Pentosyltransferases / Q000737:chemistry* / Q000235:genetics*; D011487:Protein Conformation
D009243:NAD; D010430:Pentosyltransferases; C021864:nicotinate phosphoribosyltransferase