Protozoan parasite-specific carbohydrate structures.
The carbohydrate moieties displayed by pathogenic protozoan parasites exhibit many unusual structural features and their expression is often developmentally regulated. These unique structures suggest a specific relationship between such carbohydrates and parasite pathogenicity. Studies of infected humans indicate that immune responses to protozoan parasites are elicited by glycan determinants on cell-surface or secreted molecules. Infections by protozoa are a major worldwide health problem, and no vaccines or efficacious treatments exist to date. Recent progress has been made in elucidating the structure and function of carbohydrates displayed by major protozoan parasites that infect man. These structures can be used as prototypes for the chemical or combined chemo-enzymatic synthesis of new compounds for diagnosis and vaccine development, or as inhibitors specifically designed to target parasite glycan biosynthesis.
Mendonça-Previato
Lucia
L
Laboratório de Glicobiologia, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde-Bloco G, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21 944 970, Rio de Janeiro, Brasil. luciamp@biof.ufrj.br
Todeschini
Adriane Regina
AR
Heise
Norton
N
Previato
Jose Osvaldo
JO
D000818:Animals; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000096:biosynthesis* / Q000737:chemistry / Q000276:immunology; D004748:Entamoeba histolytica / Q000276:immunology / Q000378:metabolism*; D006001:Glycoconjugates / Q000096:biosynthesis / Q000737:chemistry; D006801:Humans; D007891:Leishmania / Q000276:immunology / Q000378:metabolism*; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology / Q000378:metabolism*; D011528:Protozoan Infections / Q000276:immunology / Q000469:parasitology; D014345:Trypanosoma / Q000276:immunology / Q000378:metabolism*
D002241:Carbohydrates; D006001:Glycoconjugates