title: Yos9p: a sweet-toothed bouncer of the secretory pathway.
abstract: In this issue of Molecular Cell, Bhamidipati et al., (2005) and Kim et al., (2005), and Szathmary et al. (2005), and demonstrate that Yos9p selectively binds to aberrant glycoproteins in the endoplasmic reticulum (ER) and targets them for destruction through the ER-associated protein degradation pathway.
authors.affiliation: Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.
authors.forename: James H
authors.initials: JH
authors.lastname: Cormier
authors.forename: Bradley R
authors.initials: BR
authors.lastname: Pearse
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Hebert
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D006023:Glycoproteins; D029701:Saccharomyces cerevisiae Proteins; C495027:Yos9 protein, S cerevisiae