title: Co-evolutionary analysis of insulin/insulin like growth factor 1 signal pathway in vertebrate species.
abstract: Insulin/insulin like growth factor 1 signaling pathway plays an essential role on the regulation of variant, interrelated and fundamental processes, such as metabolism, growth, reproduction and aging. This pathway is highly conserved during evolution. We analyzed eight vertebrate species' insulin/insulin like growth factor 1 pathway and examined the co-evolutionary relationship between different protein components by quantifying similarity of phylogenetic trees. The collected species include Takifugu rubripes, Danio rerio, Xenopus laevis, Gallus gallus, Mus musculus, Rattous norvegicus, Pan troglodytes and Homo sapiens. Results show that interacting proteins in this pathway share highly co-evolutionary relationship while contrarily the proteins without interaction have low co-evolutionary relationship. We also predict some receptor and ligand partners enjoy highly binding potential in corresponding species' pathway.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China.
authors.forename: Tonghai
authors.initials: T
authors.lastname: Dou
authors.forename: Chaoneng
authors.initials: C
authors.lastname: Ji
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gu
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Kang
authors.initials: K
authors.lastname: Ying
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Yumin
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002645:Chickens; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D007328:Insulin / Q000235:genetics* / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D015233:Models, Statistical; D002679:Pan troglodytes; D051381:Rats; D017526:Receptor, IGF Type 1 / Q000235:genetics; D015398:Signal Transduction; D013045:Species Specificity; D014982:Xenopus laevis; D015027:Zebrafish
chemical_list: D007328:Insulin; D008024:Ligands; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1