Prevalence of toxic shock syndrome toxin 1-producing Staphylococcus aureus and the presence of antibodies to this superantigen in menstruating women.
Menstrual toxic shock syndrome (mTSS) is thought to be associated with colonization with toxic shock syndrome toxin 1 (TSST-1)-producing Staphylococcus aureus in women with insufficient antibody titers. mTSS has been associated with menstruation and tampon use, and although it is rare, the effects can be life threatening. It remains of interest because of the widespread use of tampons, reported to be about 70% of women in the United States, Canada, and much of Western Europe. This comprehensive study was designed to determine S. aureus colonization and TSST-1 serum antibody titers in 3,012 menstruating women in North America between the ages of 13 and 40, particularly among age and racial groups that could not be assessed reliably in previous small studies. One out of every four subjects was found to be colonized with S. aureus in at least one of three body sites (nose, vagina, or anus), with approximately 9% colonized vaginally. Eighty-five percent of subjects had antibody titers (> or =1:32) to TSST-1, and the vast majority (81%) of teenaged subjects (13 to 18 years) had already developed antibody titers. Among carriers of toxigenic S. aureus, a significantly lower percentage of black women than of white or Hispanic women were found to have antibody titers (> or =1:32) to TSST-1 (89% versus 98% and 100%). These findings demonstrate that the majority of teenagers have antibody titers (> or =1:32) to TSST-1 and are presumed to be protected from mTSS. These findings also suggest that black women may be more susceptible to mTSS than previously thought.
Parsonnet
Jeffrey
J
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Hansmann
Melanie A
MA
Delaney
Mary L
ML
Modern
Paul A
PA
Dubois
Andrea M
AM
Wieland-Alter
Wendy
W
Wissemann
Kimberly W
KW
Wild
John E
JE
Jones
Michaelle B
MB
Seymour
Jon L
JL
Onderdonk
Andrew B
AB
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000276:immunology*; D004768:Enterotoxins / Q000096:biosynthesis / Q000276:immunology*; D005260:Female; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D015995:Prevalence; D012772:Shock, Septic / Q000453:epidemiology* / Q000208:ethnology / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000208:ethnology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D018089:Superantigens / Q000096:biosynthesis / Q000276:immunology*; D014621:Vagina / Q000382:microbiology
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal