title: Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus.
abstract: Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.
authors.affiliation: Centro de Ecologia Química Agrícola, Universidad Politécnica de Valencia, Campus de Vera, Edificio 9B, Laboratorio 111, Valencia, Spain. mplopez@ceqa.upv.es
authors.forename: M Pilar
authors.initials: MP
authors.lastname: López-Gresa
authors.forename: M Carmen
authors.initials: MC
authors.lastname: González
authors.forename: Jaime
authors.initials: J
authors.lastname: Primo
authors.forename: Pilar
authors.initials: P
authors.lastname: Moya
authors.forename: Vanessa
authors.initials: V
authors.lastname: Romero
authors.forename: Ernesto
authors.initials: E
authors.lastname: Estornell
mesh_terms: D001235:Aspergillus ochraceus / Q000378:metabolism*; D001570:Benzodiazepinones / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004579:Electron Transport / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001570:Benzodiazepinones; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; C504253:circumdatin H; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases