Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation.
OBJECTIVE
To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.


METHODS
Constipation was diagnosed by Rome II criteria. Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.


RESULTS
34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs 95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of 'monitoring' coping strategy (14+/-6 vs 9+/-3, P = 0.001), which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).


CONCLUSIONS
Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology.
Chan
Annie-Oo
AO
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China. aoochan@hku.hk
Cheng
Cecilia
C
Hui
Wai-Mo
WM
Hu
Wayne-H-C
WH
Wong
Nina-Y-H
NY
Lam
K-F
KF
Wong
Wai-Man
WM
Lai
Kam-Chuen
KC
Lam
Shiu-Kum
SK
Wong
Benjamin-C-Y
BC
D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000503:physiopathology; D003248:Constipation / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012007:Rectum / Q000503:physiopathology; D013315:Stress, Psychological / Q000453:epidemiology / Q000503:physiopathology*; D011795:Surveys and Questionnaires