title: Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies.
abstract: A new EPI-based method is presented which features optimized sampling of k-space enabling the integrated acquisition of two gradient echo images. The first of these images is predominantly T1 weighted and the second is T*2 weighted. The new method combines echo sharing of sparsely acquired high spatial frequency components with the keyhole technique and half-Fourier image reconstruction. The feasibility of acquiring high spatial and temporal resolution in vivo images for perfusion mapping is demonstrated. In contrast to most current perfusion methods, which acquire the T1- and T*2-weighted images in separate acquisitions, the need for image co-registration here is obviated since both sets of images are EPI-based and are acquired within the same measurement.
authors.affiliation: Institut für Medizin, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Zaitsev
authors.forename: J
authors.initials: J
authors.lastname: D'Arcy
authors.forename: D J
authors.initials: DJ
authors.lastname: Collins
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: K
authors.initials: K
authors.lastname: Zilles
authors.forename: N J
authors.initials: NJ
authors.lastname: Shah
mesh_terms: D001921:Brain / Q000098:blood supply*; D003287:Contrast Media; D017352:Echo-Planar Imaging; D019786:Gadolinium DTPA / Q000627:therapeutic use; D006801:Humans; D007089:Image Enhancement; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA