The influence of a single dose of adriamycin on the pregnant rat female liver-histological and histochemical evaluation.
The purpose of the study was histological evaluation of the liver of a pregnant rat, which 4 weeks before planned pregnancy was administered adriamycin intraperitoneally in a dose of 5 mg/kg of body weight. Focal damage of hepatocytes ("naked nuclei" which were the evidence of cell damage) were observed in histological preparations. Significant steatosis and vessel damage were visible as well. Around the central vein and in portocholangial space numerous ductules spuriae appear.
Pedrycz
Agnieszka
A
Department of Histology and Embryology with the Laboratory for Experimental Cytology, Skubiszewski Medical University of Lublin.
Wieczorski
Marcin
M
Czerny
Krystyna
K
D000818:Animals; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D004317:Doxorubicin