Replacement of insulin by LongR3-IGF-1 allows for the differentiation of ES cells into neuroprogenitors and insulin-secreting cells.
Bieberich
Erhard
E
Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, 1120 15th Street Room CB-2803, Augusta, GA 30912, USA. ebieberich@mail.mcg.edu
D002454:Cell Differentiation / Q000187:drug effects*; D003470:Culture Media; D004622:Embryo, Mammalian / Q000166:cytology*; D004625:Embryo, Nonmammalian; D004797:Enzyme-Linked Immunosorbent Assay; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007334:Insulin-Like Growth Factor I / Q000031:analogs & derivatives* / Q000494:pharmacology; D009474:Neurons / Q000166:cytology*; D011994:Recombinant Proteins / Q000494:pharmacology; D018038:Sodium Selenite / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology*; D014168:Transferrin / Q000494:pharmacology
D003470:Culture Media; D007328:Insulin; D011994:Recombinant Proteins; D014168:Transferrin; C085700:long R(3)-insulin-like growth factor-I; D007334:Insulin-Like Growth Factor I; D018038:Sodium Selenite