title: Mucosal deformation from an impinging transonic gas jet and the ballistic impact of microparticles.
abstract: By means of a transonic gas jet, gene guns ballistically deliver microparticle formulations of drugs and vaccines to the outer layers of the skin or mucosal tissue to induce unique physiological responses for the treatment of a range of conditions. Reported high-speed imaging experiments show that the mucosa deforms significantly while subjected to an impinging gas jet from a biolistic device. In this paper, the effect of this tissue surface deformation on microparticle impact conditions is simulated with computational fluid dynamics (CFD) calculations. The microparticles are idealized as spheres of diameters 26.1, 39 and 99 microm and a density of 1050 kg m-3. Deforming surface calculations of particle impact conditions are compared directly with an immobile surface case. The relative velocity and obliquity of the deforming surface decrease the normal component of particle impact velocity by up to 30% at the outer edge of the impinging gas jet. This is qualitatively consistent with reported particle penetration profiles in the tissue. It is recommended that these effects be considered in biolistic studies requiring quantified particle impact conditions.
authors.affiliation: The PowderJect Centre for Gene and Drug Delivery Research, Department of Engineering Science, University of Oxford, 43 Banbury Rd, Oxford, OX2 6PE, UK.
authors.forename: M P
authors.initials: MP
authors.lastname: Hardy
authors.forename: M A F
authors.initials: MA
authors.lastname: Kendall
mesh_terms: D000279:Administration, Cutaneous; D000336:Aerosols; D000818:Animals; D001696:Biomechanical Phenomena; D004285:Dogs; D016503:Drug Delivery Systems; D007277:Injections, Jet; D008863:Microspheres; D009061:Mouth Mucosa
chemical_list: D000336:Aerosols