title: Evaluation of calciotropic hormones in cats with odontoclastic resorptive lesions.
abstract: OBJECTIVE
  To assess associations between epidemiologic and laboratory variables and calciotropic hormones in cats with odontoclastic resorptive lesions (ORLs).
  
  
  METHODS
  182 client-owned cats older than 1 year of age with oral disease.
  
  
  METHODS
  Information on medical history, behavior, living environment, and feeding management was assessed by use of a questionnaire. After induction of general anesthesia, oral examination was performed following standardized protocols and included dental probing and full-mouth radiography. Laboratory analyses included evaluation of FeLV-FIV status, serum biochemical analyses, CBC, urinalysis, and serum concentrations of intact parathyroid hormone (iPTH), parathyroid hormone-related peptide (PTHrP), 25-hydroxyvitamin D (25-OHD), free thyroxine (fT4), and ionized calcium (iCa).
  
  
  RESULTS
  ORLs were identified in 72.5% of cats. Mandibular third premolars were the most commonly affected teeth. Cats with ORLs were significantly older (mean, 9.2 years) than cats without ORLs (mean, 6.6 years). Multivariate logistic regression analysis revealed that 25-OHD, urine specific gravity, jaw-opening reflex on probing, and missing teeth were significant variables, even after accounting for age. Cats with ORLs had significantly higher mean serum concentration of 25-OHD (112.4 nmol/L) and significantly lower mean urine specific gravity (1.0263), compared with cats without ORLs (89.8 nmol/L and 1.0366, respectively).
  
  
  CONCLUSIONS
  Results did not indicate associations between iPTH, PTHrP, or fT4 and development of ORLs. In affected cats, the importance of high serum 25-OHD and low urine specific gravity has not been determined.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Reiter
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Lyon
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Nachreiner
authors.forename: Frances S
authors.initials: FS
authors.lastname: Shofer
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood; D002371:Cat Diseases / Q000097:blood / Q000378:metabolism*; D002415:Cats; D010281:Parathyroid Hormone / Q000097:blood; D044162:Parathyroid Hormone-Related Protein / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014091:Tooth Resorption / Q000097:blood / Q000662:veterinary*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D013974:Thyroxine; D002118:Calcium