Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models.
The gastroprotective activity of phytosphingosine hydrochloride (PS-HCl, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCI were orally administered to rats 30 min before the treatment with HCl/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCl (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCl/ethanol-induced gastric mucosal membrane lesions (20.1-47.8% inhibition), (2) indometacin-induced gastric mucosal membrane lesions (4.6-31.9% inhibition), (3) duodenal ulcer induced by cysteamine (10-20% inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9% inhibition). These results indicate that PS-HCI may be useful for the prevention of gastric ulcer.
Baek
Seung Woo
SW
Laboratory of Biochemical Engineering, Department of Chemical Engineering, Sung kyun kwan University, Suwon, Korea.
Kim
Nam Ki
NK
Jin
Hwan-Jun
HJ
Koh
Chang-Woong
CW
Kim
Chul Kyung
CK
Kwon
O-Hyep
OH
Kim
Jun-Sung
JS
Cho
Myung-Haing
MH
Park
Chan-Koo
CK
D000818:Animals; D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology; D006851:Hydrochloric Acid; D008026:Ligation; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D011453:Prostaglandins; D000431:Ethanol; D003543:Cysteamine; C012491:phytosphingosine; D013110:Sphingosine; D006851:Hydrochloric Acid