Immunohistochemical study of progesterone receptors in thyroid gland.
OBJECTIVE
To determine the progesterone receptor status in thyroid gland.


METHODS
This study was based on immunohistochemical staining of formalin fixed paraffin embedded tissues, for progesterone receptors, in 50 previously diagnosed cases of various thyroid lesions and surrounding normal thyroid tissue.


RESULTS
Out of 50 cases, 8 were nodular goiter, 9 cases of adenoma, 19 papillary carcinoma, 10 follicular carcinoma and four cases were of medullary carcinoma. Surrounding normal tissue was available in 4 non-neoplastic and 21 neoplastic lesions. Overall male patients comprised 20% (10 cases) and females 80% (40 cases). Although a wide range of lesions in both the sexes including wide age range were available, none of our cases were positively stained for progesterone receptors.


CONCLUSIONS
In contrary to earlier reports by immunohistochemical method using monoclonal mouse anti-PR antibody clone PgR 636, on formalin-fixed paraffin embedded thyroid tissues, the progesterone receptors were not detectable in our human samples. The effect of progesterone on thyroid gland may be an indirect one.
Memon
Ghulam Rasool
GR
Sindh Government Hospital Kemari, Karachi.
Arain
Shoukat Ali
SA
Jamal
Qamar
Q
Ansari
Tazeen
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000911:Antibodies, Monoclonal; D004396:Coloring Agents; D005260:Female; D006044:Goiter, Nodular / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007202:Indicators and Reagents; D008297:Male; D008875:Middle Aged; D011980:Receptors, Progesterone / Q000187:drug effects / Q000276:immunology*; D011989:Receptors, Thyrotropin / Q000187:drug effects / Q000276:immunology; D012737:Sex Factors; D013961:Thyroid Gland / Q000276:immunology* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D004396:Coloring Agents; D007202:Indicators and Reagents; D011980:Receptors, Progesterone; D011989:Receptors, Thyrotropin