Stauffer's syndrome variant associated with renal cell carcinoma.
Cholestasis, as a paraneoplastic syndrome, has been well described in patients with malignant lymphohyperplastic diseases and renal cell cancer. Non-metastatic nephrogenic hepatic dysfunction syndrome without jaundice has often been described in patients with Stauffer's syndrome. Paraneoplastic cholestatic jaundice is extremely uncommon. We report, a patient who presented with pruritus and cholestatic jaundice and was diagnosed with renal cell carcinoma (RCC) in the right kidney. Liver malfunction and cholestatic icterus was attributed to RCC. Jaundice and liver dysfunction gradually restored to normal after surgical resection of the tumor. Malignancies may cause cholestatic jaundice through well-recognized mechanisms. Paraneoplastic syndromes associated with malignancy, can induce a reversible form of cholestasis through an unclear pathogenetic mechanism.
Giannakos
George
G
1st Department of Internal Medicine, 401 General Army Hospital of Athens, Athens, Greece.
Papanicolaou
Xenofon
X
Trafalis
Dimitrios
D
Michaelidis
Isaak
I
Margaritis
George
G
Christofilakis
Charalambos
C
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000601:surgery; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology* / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D013577:Syndrome