title: The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells.
abstract: We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal controls and in normal cells isolated from CLL patients. Thus, Mcl-1 insertions are not acquired during leukemogenesis and are unlikely to play an important role in this disease.
authors.forename: Silvia
authors.initials: S
authors.lastname: Coenen
authors.forename: Becky
authors.initials: B
authors.lastname: Pickering
authors.forename: Kathleen N
authors.initials: KN
authors.lastname: Potter
authors.forename: Peter W M
authors.initials: PW
authors.lastname: Johnson
authors.forename: Freda K
authors.initials: FK
authors.lastname: Stevenson
authors.forename: Graham
authors.initials: G
authors.lastname: Packham
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004251:DNA Transposable Elements / Q000235:genetics*; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2