Polymer-micelle incarcerated scandium as a polymer-supported catalyst for high-throughput organic synthesis.
A novel immobilization technique for Sc(OTf)3, a polymer-micelle incarcerated (PMI) method, has been developed. PMI Sc(OTf)3 is highly active in several fundamental carbon-carbon bond-forming reactions. The catalyst is recovered quantitatively by simple filtration and reused several times without loss of catalytic activity, and no Sc leaching was observed in all reactions (<0.1 ppm). In addition, several solvents are available, and these aspects are suitable for high-throughput organic synthesis (HTOS). To the best of our knowledge, this is the first example of immobilization of Lewis acids utilizing polymer micelles.
Takeuchi
Masahiro
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency, Tokyo 113-0033, Japan.
Akiyama
Ryo
R
Kobayashi
Shu
S
D002384:Catalysis; D008823:Micelles; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
D008823:Micelles; D009930:Organic Chemicals; D009942:Organometallic Compounds; D011108:Polymers; D012997:Solvents; D012538:Scandium