Evaluation of mutagenic and genotoxic activities of new derivatives of anthracyclines.
The phenomenon of multidrug resistance is connected with an increased efflux of cytotoxic agents from the cells and is a serious problem in the treatment with anthracycline antibiotics. Search for new antitumor drugs from the anthracycline group are focused on the syntheris of derivatives with changes in saccharide and anthracycline parts. The genotoxic activity of selected nine new derivatives of anthracycline was evaluate basing on reference tests: micronucleus test in vitro and the Ames test. A correlation was observed between the results obtained in the Ames test and those received in the micronucleus test. In both tests, derivative WP903 demonstrated a strong genotoxic action.
Chłopkiewicz
Bozena
B
Department of Biochemistry and Biopharmaceuticals, National Institute of Public Health, 30/34 Chełmnska Str., 00-725 Warsaw, Poland.
Ejchart
Anna
A
Marczewska
Jadwiga
J
Anuszewska
Elzbieta
E
Priebe
Waldemar
W
D000818:Animals; D018943:Anthracyclines / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006801:Humans; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D009152:Mutagenicity Tests / Q000379:methods*; D009154:Mutation / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D018943:Anthracyclines; D004317:Doxorubicin