Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene.
Kiess
W
W
Hospital for Children and Adolescents, University of Leipzig, Oststr. 21-25, D-04317, Leipzig, Germany. kiw@medizin.uni-leipzig.de
Kratzsch
J
J
Keller
E
E
Schneider
A
A
Raile
K
K
Klammt
J
J
Seidel
B
B
Garten
A
A
Schmidt
H
H
Pfäffle
R
R
D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D005317:Fetal Growth Retardation / Q000235:genetics*; D006130:Growth Disorders / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008297:Male; D010641:Phenotype; D017354:Point Mutation; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis / Q000235:genetics*
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1