Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa.
The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, compounds 1-4, have been isolated, and their structures established through spectroscopic methods. Compounds 1-4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.
Aiello
Anna
A
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.
D'Esposito
Monica
M
Fattorusso
Ernesto
E
Menna
Marialuisa
M
Müller
Werner E G
WE
Perović-Ottstadt
Sanja
S
Schröder
Heinz C
HC
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002855:Chromatography, Thin Layer; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016318:Quisqualic Acid / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000470:Alkaloids; D018691:Excitatory Amino Acid Antagonists; D011758:Pyrroles; D012702:Serotonin Antagonists; D012701:Serotonin; D018698:Glutamic Acid; D016318:Quisqualic Acid; D002118:Calcium