[Nonexpressor of pathogenesis-related genes 1 (NPR1): a key node of plant disease resistance signalling network].
The NPRI (nonexpressor of pathogenesis-related genes (1) gene, firstly cloned in Arabidopsis thaliana, is a key gene involved in regulation of plant disease resistance. It plays a pivotal role not only in systemic acquired resistance (SAR) and induced systemic resistance (ISR), but also in basic resistance and resistance (R) gene-dependent resistance. NPR1 monomerization induced by enhanced reducing condition after oxidative burst, and the accumulation of NPR1 monomers in the nuclei, are required and enough for expression of PR (pathogenesis-related) genes and SAR. NPR1 regulates PR gene expression through interaction with TGA transcription factors (TF). As a cross-talk point of a variety of defense signaling pathways, probably through direct or indirect interacting with some WRKY TFs and a NPR1-like protein NPR4, NPR1 is essential in balancing salicylic acid- and jasmonic acid- dependent signal transduction pathways, which is achieved through an unknown mechanism in the cytosol. The possible application of NPR1 in plant protection is also discussed in this review.
Zhang
Hong-Zhi
HZ
Institute of Biotechnology, and Department of Plant Protection, Zhejiang University, Hangzhou 310029, China.
Cai
Xin-Zhong
XZ
D029681:Arabidopsis Proteins / Q000235:genetics*; D003517:Cyclopentanes / Q000378:metabolism / Q000494:pharmacology; D018506:Gene Expression Regulation, Plant / Q000235:genetics*; D054883:Oxylipins / Q000378:metabolism / Q000494:pharmacology; D010935:Plant Diseases / Q000235:genetics*; D030821:Plants, Genetically Modified; D020156:Salicylic Acid / Q000378:metabolism / Q000494:pharmacology; D015398:Signal Transduction
D029681:Arabidopsis Proteins; D003517:Cyclopentanes; C105496:NPR1 protein, Arabidopsis; D054883:Oxylipins; C011006:jasmonic acid; D020156:Salicylic Acid