title: Metachronous extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and peripheral T-cell lymphoma unspecified: histologic, immunophenotypic, and molecular documentation.
abstract: BACKGROUND
  Coexistence of B- and T-cell lymphoid malignancies has been reported sporadically.
  
  
  METHODS
  A 68-year-old woman developed a lymphoid neoplasm in the large intestine and a second lymphoid neoplasm in the esophagus, 24 months after the diagnosis of the first lymphoma. Immunophenotypic analyses were consistent with extranodal marginal zone B-cell mucosa-associated lymphoid tissue type (MALT type) and peripheral T-cell unspecified lymphomas in the large intestine and the esophagus, respectively. The molecular analysis confirmed the B-clonal genotype of the first lymphoma, and disclosed a biclonal genotype of the second one (composite T- and B-cell lymphoma). No evidence of Epstein-Barr virus (EBV) association was shown in either tumor.
  
  
  CONCLUSIONS
  B- and T-cell neoplasms represent two distinct malignancies rather than progression of the same neoplastic clone.
authors.affiliation: Department of Pathology, Ippokration Hospital of Salonica, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Venizelos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papadopoulos
authors.forename: Maria
authors.initials: M
authors.lastname: Lambropoulou
authors.forename: Sylvia
authors.initials: S
authors.lastname: Nikolaidou
authors.forename: Sophia
authors.initials: S
authors.lastname: Bolioti
authors.forename: Demetrio
authors.initials: D
authors.lastname: Tamiolakis
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D014408:Biomarkers, Tumor / Q000235:genetics; D001706:Biopsy; D003110:Colonic Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000276:immunology / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D004947:Esophagus / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D019675:Genes, T-Cell Receptor gamma; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D016130:Immunophenotyping; D007413:Intestinal Mucosa / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D016133:Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D014408:Biomarkers, Tumor; D007075:Immunoglobulin M