Vaccine-induced CD8+ central memory T cells in protection from simian AIDS.
Critical to the development of an effective HIV vaccine is the identification of adaptive immune responses that prevent infection or disease. In this study we demonstrate in a relevant nonhuman primate model of AIDS that the magnitude of vaccine-induced virus-specific CD8(+) central memory T cells (T(CM)), but not that of CD8(+) effector memory T cells, inversely correlates with the level of SIVmac251 replication, suggesting their pivotal role in the control of viral replication. We propose that effective preventive or therapeutic T cell vaccines for HIV-1 should induce long-term protective central memory T cells.
Vaccari
Monica
M
Animal Models and Retroviral Vaccines Section and National Cancer Institute, Bethesda, MD 20892, USA.
Trindade
Christopher J
CJ
Venzon
David
D
Zanetti
Maurizio
M
Franchini
Genoveffa
G
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015683:Gene Products, gag / Q000008:administration & dosage / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D016056:Immunodominant Epitopes / Q000008:administration & dosage / Q000276:immunology; D007156:Immunologic Memory / Q000187:drug effects; D016130:Immunophenotyping; D008251:Macaca; D018449:SAIDS Vaccines / Q000008:administration & dosage / Q000494:pharmacology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000628:therapy*; D015302:Simian Immunodeficiency Virus / Q000187:drug effects; D014766:Viremia / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
D015683:Gene Products, gag; D016056:Immunodominant Epitopes; D018449:SAIDS Vaccines