title: A comparison of CH3-DTPA-GD (NMS60) and GD-DTPA for evaluation of acute myocardial ischemia.
abstract: OBJECTIVE
  Our objective was to evaluate the use of a new medium weight MRI contrast agent, NMS60 (a synthetic oligomeric Gd-complex containing three Gd(3+) atoms, molecular weight 2158 Da) compared to gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) in a pig myocardial ischemia model.
  
  
  METHODS
  We used 13 male white hybrid pigs. Animals were scanned in the acute phase 2-3 h after the onset of myocardial ischemia. Scans were acquired on a 1.5T GE Signa with dynamic T1-weighted imaging during a bolus injection of 0.1 mmol(gd)/kg of either NMS60 or Gd-DTPA, 2D CINE at 5 min after injection, and T1-weighted spin-echo imaging up to 60 min.
  
  
  RESULTS
  The postcontrast CINE scans showed improved contrast-to-noise ratio after NMS60 injection, compared to Gd-DTPA. There was significantly greater enhancement with NMS60 in both normal myocardium and in the ischemic lesion on T1-weighted spin-echo scans up to 60 min after injection. The dose ranging study shows a 24% greater enhancement with NMS60 compared to Gd-DTPA.
  
  
  CONCLUSIONS
  This new medium weighted contrast agent offers improved enhancement for cardiac MRI, compared to Gd-DTPA, with similar washout kinetics and lower toxicity, and may prove useful for better detection of myocardial ischemia as well as delayed or hyperenhancement after reperfusion.
authors.affiliation: Lucas MRS/I Center, Department of Radiology, Stanford University, CA, USA. helen@nmr.mgh.harvard.edu
authors.forename: H E
authors.initials: HE
authors.lastname: D'Arceuil
authors.forename: A J
authors.initials: AJ
authors.lastname: de Crespigny
authors.forename: L
authors.initials: L
authors.lastname: Pelc
authors.forename: D
authors.initials: D
authors.lastname: Howard
authors.forename: S
authors.initials: S
authors.lastname: Seri
authors.forename: Y
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: A
authors.initials: A
authors.lastname: Nakatani
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
mesh_terms: D000208:Acute Disease; D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D019786:Gadolinium DTPA; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D017202:Myocardial Ischemia / Q000473:pathology*; D009942:Organometallic Compounds; D013552:Swine
chemical_list: D003287:Contrast Media; C403805:NMS60; D009942:Organometallic Compounds; D019786:Gadolinium DTPA