title: Combination of nucleoside analogues tiazofurin and ribavirin downregulates experimental autoimmune encephalomyelitis.
abstract: The effect of combined treatment with ribavirin and tiazofurin on the development of experimental autoimmune encephalomyelitis, the best characterized animal model for human autoimmune disease multiple sclerosis, was investigated. The disease was induced in highly susceptible Dark Agouti rats with spinal cord homogenate in complete Freund's adjuvant. Although ribavirin or tiazofurin alone reduced the clinical and histopathological signs of experimental autoimmune encephalomyelitis, the combination of drugs achieved the same effect with significantly lower doses.
authors.affiliation: Department of Neurobiology and Immunology, Institute for Biological Research Sinisa Stanković, Belgrade, Serbia & Montenegro. irenam@ibiss.bg.ac.yu
authors.forename: Irena
authors.initials: I
authors.lastname: Lavrnja
authors.forename: Danijela
authors.initials: D
authors.lastname: Stojkov
authors.forename: Sanja
authors.initials: S
authors.lastname: Peković
authors.forename: Sanja
authors.initials: S
authors.lastname: Subasic
authors.forename: Marija
authors.initials: M
authors.lastname: Mostarica-Stojković
authors.forename: Stanislava
authors.initials: S
authors.lastname: Stosic-Grujicić
authors.forename: Nadezda
authors.initials: N
authors.lastname: Nedeljković
authors.forename: Ljubica
authors.initials: L
authors.lastname: Medic-Mijacević
authors.forename: Ljubisav
authors.initials: L
authors.lastname: Rakić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Stojiljkovi
mesh_terms: D000818:Animals; D015536:Down-Regulation; D004338:Drug Combinations; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005620:Freund's Adjuvant / Q000627:therapeutic use; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D012254:Ribavirin; D005620:Freund's Adjuvant; C033706:tiazofurin