[Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone on renal fibroblast in rats].
OBJECTIVE
To explore the curative effects of 1-(3-fluorophenyl)-5-methyl-2- (1H)-pyridone (FMP) on renal fibrosis in rats.


METHODS
The effects of FMP on the cell proliferation and Fn secretion were measured by methyl thiazolyl tetrazolium and enzyme-linked immunoabsorbent assay, respectively.


RESULTS
FMP obviously inhibited the proliferation and Fn secretion in rat renal fibroblast 48 hours after the treatment. FMP (1 000 microg/ml) obviously inhibited the proliferation of rat renal fibroblast 24 hours after the treatment.


CONCLUSIONS
1-(3-Fluorophenyl) -5-methyl-2-(1H)-pyridone can obviously inhibit the proliferation of rat renal fibroblast, which may be effective for renal interstitial fibrosis prevention and treatment.
Tao
Li-Jian
LJ
Department of Nephrology, Xiangya Hospital, School of Pharmaceutical Science, Central South University, Changsha 410008, China. Taolj@xysm.net
Zhang
Jun
J
Hu
Gao-Yun
GY
D000818:Animals; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005353:Fibronectins / Q000378:metabolism*; D005355:Fibrosis / Q000517:prevention & control; D007668:Kidney / Q000166:cytology / Q000473:pathology*; D011728:Pyridones / Q000494:pharmacology*; D051381:Rats
C511655:5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone; D005353:Fibronectins; D011728:Pyridones