[Research advancement on heparanase in tumor metastasis].
Heparanase is the only mammalian heparan sulfate-degrading enzymes; it could cleave heparan sulfate (HS) which links to heparan sulfate proteoglycans (HSPGs). In this review, the heparanase's structure, function, molecular properties, gene location, nucleotide sequence, its effects on tumor angiogenesis, its expression in normal tissue, tumor tissue and metastatic tissue, and its correlation to tumor metastasis were described; recent progress in searching for novel antitumor drugs through screening for inhibitor of heparanase was summarized.
Li
Zhi-Hong
ZH
Department of Gastroenterology, Southwest Hospital, The Third Military Medical University, Chongqing, P.R. China.
Yang
Shi-Ming
SM
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D005966:Glucuronidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000201:enzymology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000099175:Heparanase
D005966:Glucuronidase; D006497:Heparan Sulfate; D012333:RNA, Messenger; D000099175:Heparanase