Antibodies to borna disease virus in subacute sclerosing panencephalitis.
Mechanisms causing persistence and reactivation of measles virus in subacute sclerosing panencephalitis (SSPE) are unknown. Borna disease virus (BDV) frequently causes latent or persistent infection in the nervous system. We investigated a possible association of these viruses in SSPE. Although BDV seropositivity was similar in SSPE and control groups, SSPE patients with high antibodies to BDV had earlier and more rapid disease. The findings suggest that BDV might be involved in the course, but not in the etiopathogenesis, of SSPE.
Güngör
Serdal
S
Department of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey. banlar@hacettepe.edu.tr
Anlar
Banu
B
Turan
Nuri
N
Yilmaz
Hüseyin
H
Helps
Chris R
CR
Harbour
Dave A
DA
D000293:Adolescent; D017677:Age Distribution; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis* / Q000276:immunology; D001890:Borna Disease / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D001891:Borna disease virus / Q000276:immunology* / Q000302:isolation & purification; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D013190:SSPE Virus / Q000276:immunology / Q000302:isolation & purification; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D017678:Sex Distribution; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D015996:Survival Rate
D000914:Antibodies, Viral