[Effectiveness of plaferon LB in gamma-radiotherapy].
Free radical oxidation plays important role in the radiation-induced cell and tissue damage. Numerous studies evidence a decrease in body antioxidant system activity and changes in nitric oxide levels during irradiation. It has been demonstrated that in the process of radiation damage NO may play either radioprotective or radiotoxic role depending on body redox status. Hence, the search for effective radioprotectors is an urgent issue of the contemporary radiology. We applied vitamin C and plaferon LB as radioprotectors. Plaferon LB has antioxidant, antihypoxic, immunomodulating and antiapoptotic effects. Our study aimed to evaluate effectiveness of correcting action of plaferon LB on oxidative -- reducing balance of the body subjected to ionizing radiation. There have been studied changes in catalase, SOD, GR and ceruloplasmine activities as well as blood NO levels, superoxide and lipoperoxide radical levels in rats being subjected to gamma-radiation and treated by above mentioned preparations. As a result of our study we can conclude that preliminary and postradiation application of antioxidants at irradiation has a protective effect.
Saralidze
M A
MA
Papava
M B
MB
Datunashvili
I T
IT
Sanikidze
T V
TV
Bakhutashvili
V I
VI
D000818:Animals; D002374:Catalase / Q000378:metabolism*; D005720:Gamma Rays; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology*; D011832:Radiation Injuries / Q000188:drug therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D016896:Treatment Outcome
D009479:Neuropeptides; C091912:plaferon; D002374:Catalase; D013482:Superoxide Dismutase