Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase.
Inhibitors of mammalian ribonucleotide reductase possessing a novel octahydropyranopyrrole scaffold based on a cyclic heptapeptide inhibitor have been designed, synthesized, and evaluated. Structure-function studies reveal that the bicyclic scaffold is indeed necessary to maintain inhibitory activity.
Fuertes
Michael J
MJ
Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kaur
Jaskiran
J
Deb
Prasant
P
Cooperman
Barry S
BS
Smith
Amos B
AB
D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D011714:Pyrans; D011758:Pyrroles; D012264:Ribonucleotide Reductases