Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551.
Malnutrition is common in the developing world, where tuberculosis is often endemic. Rabbits infected with aerosolized Mycobacterium tuberculosis that subsequently became inadvertently and transiently malnourished had compromised cell-mediated immunity comparable to that of the rabbits immunosuppressed with dexamethasone. They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses.
Kesavan
Anup K
AK
Department of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
Mendez
Susana E
SE
Hatem
Christine L
CL
Lopez-Molina
Javier
J
Aird
Katherine
K
Pitt
M Louise M
ML
Dannenberg
Arthur M
AM
Manabe
Yukari C
YC
D000336:Aerosols; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003907:Dexamethasone / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D008168:Lung / Q000382:microbiology; D044342:Malnutrition / Q000276:immunology*; D009169:Mycobacterium tuberculosis; D011817:Rabbits; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000276:immunology*
D000336:Aerosols; D003907:Dexamethasone