title: The association of macro- and microstructure of the corpus callosum and language lateralisation.
abstract: The present study aimed to examine how differences in functional lateralisation of language are related to interindividual variations in interhemispheric connectivity. Utilising an fMRI silent word-generation paradigm, 89 left- and right-handed subjects were subdivided into four lateralisation subgroups. Applying morphological and diffusion-tensor MRI, midsagittal cross-sectional area as well as quantitative measures of molecular diffusion (anisotropy, mean diffusion) of the corpus callosum were determined to assess interhemispheric connectivity. Statistical analyses revealed group differences in molecular diffusion but not in callosal size, which may be interpreted to reflect a stronger and/or faster interhemispheric connection in strongly left-lateralised subjects as compared to moderately left-lateralised, bilateral, or moderately right-lateralised subjects.
authors.affiliation: Center for Neuropsychological Research, University of Trier, Germany. westerhausen@znf.uni-trier.de
authors.forename: René
authors.initials: R
authors.lastname: Westerhausen
authors.forename: Frank
authors.initials: F
authors.lastname: Kreuder
authors.forename: Sarah
authors.initials: S
authors.lastname: Dos Santos Sequeira
authors.forename: Christof
authors.initials: C
authors.lastname: Walter
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Woerner
authors.forename: Ralf Arne
authors.initials: RA
authors.lastname: Wittling
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schweiger
authors.forename: Werner
authors.initials: W
authors.lastname: Wittling
mesh_terms: D000328:Adult; D003337:Corpus Callosum / Q000033:anatomy & histology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D014705:Verbal Behavior