A model for immunological correlates of protection.
Immunological assays measure characteristics of the immune system, such as antibody levels, specific to certain diseases. High assay values are often associated with protection from disease. A question of interest is how the relationship between assay values and subsequent development of disease should be quantitatively modelled. Existing approaches successfully model the relationship for high assay values, where the probability of developing disease is low. However at low assay values, the probability of developing disease is more closely associated with factors such as disease prevalence rates and an individual's chance of exposure to infection; these are less well captured by existing models. This paper presents a model that accommodates both assay values and factors independent of assay values, enabling protection from disease to be modelled over the whole range of assay values and proposing a method for predicting the efficacy of a vaccine from the assays of vaccinees and non-vaccinees.
Dunning
Andrew J
AJ
Wyeth Vaccines Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. adunning@alumni.washington.edu
D000907:Antibodies, Bacterial / Q000097:blood; D002986:Clinical Trials as Topic / Q000379:methods*; D003141:Communicable Diseases / Q000276:immunology*; D003627:Data Interpretation, Statistical; D022422:Diphtheria-Tetanus Vaccine / Q000627:therapeutic use; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000627:therapeutic use; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000627:therapeutic use; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D018448:Models, Immunological; D014611:Vaccination / Q000379:methods*; D014917:Whooping Cough / Q000517:prevention & control
D000907:Antibodies, Bacterial; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G