title: New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp.
abstract: Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.
authors.affiliation: Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan. hosotani@sumitomopharm.co.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hosotani
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kumagai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimatani
authors.forename: Ikutaro
authors.initials: I
authors.lastname: Saji
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D018922:HL-60 Cells; D006801:Humans; D018942:Macrolides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D008968:Molecular Conformation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C504250:SPA 6952A; C504251:SPA 6952B