Do NK cells regulate human autoimmunity?
Natural killer cells have been shown to regulate autoimmune responses under experimental conditions in animals. However, a similar role for human NK cells has not been investigated, although NK cells constitute a significant fraction of the infiltrating cells in a range of autoimmune diseases. This review investigates the evidence, both theoretical and experimental, for the involvement of these cells in human immunopathology.
Pazmany
Laszlo
L
Academic Rheumatology Unit, School of Medicine, University of Liverpool, UK. lpazmany@liv.ac.uk
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D015551:Autoimmunity / Q000502:physiology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007378:Interleukins / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice
D007378:Interleukins