Refractory anemia with ringed sideroblasts and chronic myelomonocytic leukemia: myelodysplastic/myeloproliferative disease.
Here is reported the case of an elderly woman that, after surgical intervention, showed an important anemia, leucocytosis and thrombocytopenia. The leucocytosis was accompanied with clean increase of the monocytes. The morphological appearances, both peripheral blood and bone marrow, showed an evident overlapping of myelodysplastic and myeloproliferative picture, characterized from the presence of refractory anemia with ringed sideroblasts (RARS) and chronic myelomonocytic leukemia (CMML). The case has been reported because it is not frequent, besides, the CMML, until from the beginning of French-American-British (FAB) classification application, has raised problems of classification. Currently, the World Health Organization (WHO) has given an arrangement to the hematological picture with myelodysplastic and myeloproliferative morphological appearances, including this pathology in a new category: myelodysplastic/myeloproliferative diseases (MDS/MPD).
D'Angelo
Guido
G
Azienda Ospedaliera S. Antonio Abate - Gallarate, Laboratorio di Chimica-Clinica, Ematologia e Microbiologia, Varese, Italy. danguido@libero.it
D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000150:complications / Q000473:pathology*; D000756:Anemia, Sideroblastic / Q000150:complications / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000378:metabolism*