title: Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes.
abstract: A series of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes were synthesized from nucleophilic opening of oxirane with different amines. These compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25microg/ml.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India. gautam_panda@lycos.com
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
authors.lastname: Shagufta
authors.forename: Anil K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Sudhir
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008697:Methane / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D010616:Phenanthrenes; D008697:Methane