Hydrodynamic fabrication of polymeric barcoded strips as components for parallel bio-analysis and programmable microactuation.
In this paper, we report a novel technique for the manufacture of polymeric barcoded strips having diverse characteristics such as biocatalyst-based sensing and pH-responsive actuation. The fabrication involves the use of both a microfluidic platform and in-situ photopolymerization. It is expected that this method, which is a very simple, cost-effective, and environment-friendly means for mass production, will facilitate the stable immobilization of diverse biological substances such as enzymes, DNA, and antigens. Therefore, we fabricated an enzyme-immobilized barcoded strip for multiple bio-analysis. On the basis of this technology, we adopted different materials and thereby fabricated programmable microactuation components that are responsive to pH variation.
Kim
SungRak
S
Department of Biomedical Engineering, Dankook University, San 29, Anseo-dong, Cheonan 330-714, South Korea.
Oh
HyunJik
H
Baek
JuYeoul
J
Kim
HyugHan
H
Kim
WooSeung
W
Lee
SangHoon
S
D000941:Antigens / Q000737:chemistry; D002384:Catalysis; D004247:DNA / Q000737:chemistry; D004129:Dimethylpolysiloxanes; D004563:Electrochemistry; D046209:Electrophoresis, Microchip / Q000295:instrumentation / Q000379:methods; D004798:Enzymes / Q000737:chemistry; D004867:Equipment Design; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry; D008027:Light; D008832:Microchemistry; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D044085:Microfluidics; D008856:Microscopy, Fluorescence; D008956:Models, Chemical; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010777:Photochemistry; D011108:Polymers / Q000737:chemistry*; D040081:Protein Array Analysis / Q000379:methods; D013997:Time Factors
D000941:Antigens; D004129:Dimethylpolysiloxanes; D004798:Enzymes; D011108:Polymers; D019344:Lactic Acid; D004247:DNA