title: Acylated quercetagetin glycosides with antioxidant activity from Tagetes maxima.
abstract: The fractionation of a methanolic extract of Tagetes maxima guided for antioxidant activity resulted in the isolation of three acylated quercetagetin glycosides, quercetagetin-7-O-(6-O-caffeoyl-beta-D-glucopyranoside), quercetagetin-7-O-(6-O-p-coumaroyl-beta-D-glucopyranoside) and quercetagetin-7-O-(6-O-galloyl-beta-D-glucopyranoside), as well as four known flavonoid glycosides. The structural elucidation was accomplished by spectroscopic methods (ESI-MS/MS and NMR). The antioxidant activity of fractions and isolated compounds was determined by checking the scavenging activity against three different radicals: 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH*), hydroxyl (*OH), and superoxide (O2*-). The three isolated compounds exhibited a high radical scavenging activity in comparison with reference compounds.
authors.affiliation: Departament de Productes Naturals, Biologia Vegetal i Edafologia, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Catalonia, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Parejo
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastida
authors.forename: Francesc
authors.initials: F
authors.lastname: Viladomat
authors.forename: Carles
authors.initials: C
authors.lastname: Codina
mesh_terms: D000215:Acylation; D001713:Biphenyl Compounds / Q000737:chemistry; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047309:Flavones; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006834:Hydrazines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010851:Picrates; D035261:Plant Components, Aerial / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship; D031686:Tagetes / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D002867:Chromones; D047309:Flavones; D016166:Free Radical Scavengers; D005609:Free Radicals; D006027:Glycosides; D006834:Hydrazines; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; C079163:quercetagetin