title: Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides.
abstract: SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor.
authors.affiliation: Respiratory & Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. john.cumming@astrazeneca.com
authors.forename: John G
authors.initials: JG
authors.lastname: Cumming
authors.forename: Anne E
authors.initials: AE
authors.lastname: Cooper
authors.forename: Ken
authors.initials: K
authors.lastname: Grime
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Logan
authors.forename: Sharon
authors.initials: S
authors.lastname: McLaughlin
authors.forename: John
authors.initials: J
authors.lastname: Oldfield
authors.forename: John S
authors.initials: JS
authors.lastname: Shaw
authors.forename: Howard
authors.initials: H
authors.lastname: Tucker
authors.forename: Jon
authors.initials: J
authors.lastname: Winter
authors.forename: David
authors.initials: D
authors.lastname: Whittaker
mesh_terms: D000818:Animals; D044482:Benzeneacetamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D065100:CCR5 Receptor Antagonists; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D051381:Rats; D019713:Receptors, CCR5 / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D044482:Benzeneacetamides; D065100:CCR5 Receptor Antagonists; D008024:Ligands; D010880:Piperidines; D019713:Receptors, CCR5; C032727:piperidine