title: Outbreak of carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-23 in a tertiary care hospital of Papeete, French Polynesia.
abstract: Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 24 patients between March and May 2004 at the Centre Hospitalier de Polynésie Française, Tahiti, French Polynesia. The isolates were multidrug resistant, produced the carbapenemase OXA-23, and belonged to a single clone presenting several subtypes, suggesting an endemic situation. This study further illustrates the global spread of this kind of beta-lactamase-mediated resistance.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. thierry.naas@bct.ap-hop-paris.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Naas
authors.forename: Marc
authors.initials: M
authors.lastname: Levy
authors.forename: Claire
authors.initials: C
authors.lastname: Hirschauer
authors.forename: Hélène
authors.initials: H
authors.lastname: Marchandin
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D015780:Carbapenems / Q000494:pharmacology*; D002648:Child; D004196:Disease Outbreaks; D005260:Female; D006745:Hospital Bed Capacity, 300 to 499; D006761:Hospitals; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011114:Polynesia / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases; C063912:carbapenemase