Pancytopenia after a single intradermal infiltration of methotrexate.
Methotrexate-related hematologic toxicity may include leukopenia, thrombocytopenia, megaloblastic anemia, and pancytopenia. We report a woman with hypertensive renal disease who was receiving hemodialysis and developed pancytopenia following a single intradermal infiltration of 25 mg of methotrexate. Caution should be exercised when considering the use of either systemic or intralesional methotrexate therapy in patients with risk factors that have been implicated in the development of adverse hematologic side effects: renal dysfunction, possible drug interactions, and advanced age.
Cohen
Philip R
PR
Dermatologic Surgery Center of Houston, PA, Houston, TX 77030-1342, USA.
Schulze
Keith E
KE
Nelson
Bruce R
BR
D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications; D007271:Injections, Intradermal; D016030:Kidney Transplantation; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D010198:Pancytopenia / Q000139:chemically induced* / Q000473:pathology; D006435:Renal Dialysis
D003879:Dermatologic Agents; D008727:Methotrexate