Intramolecular interactions in the triplet excited states of benzophenone-thymine dyads.
Time-resolved and product studies on the synthesized dyads 1 and 2 have provided evidence that the benzophenone-to-thymine orientation strongly influences intramolecular photophysical and photochemical processes. The prevailing reaction mechanism has been established as a Paterno-Büchi cycloaddition to give oxetanes 3-6; however, the ability of benzophenone to achieve a formal hydrogen abstraction from the methyl group of thymidine has also been evidenced by the formation of photoproducts 7 and 8. These processes have been observed only in the case of the cisoid dyad 1. Adiabatic photochemical cycloreversion of the oxetane ring is achieved upon direct photolysis to give the starting dyad 1 in its excited triplet state. The photobiological implications of the above results are discussed with respect to benzophenone-photosensitized damage of thymidine.
Belmadoui
Noureddine
N
Instituto de Tecnología Química UPV-CSIC/Departamento de Química, Universidad Politécnica de Valencia, Avda de los Naranjos s/n, 46022 Valencia, Spain.
Encinas
Susana
S
Climent
Maria J
MJ
Gil
Salvador
S
Miranda
Miguel A
MA
D001577:Benzophenones / Q000737:chemistry* / Q000528:radiation effects; D004988:Ethers, Cyclic / Q000138:chemical synthesis / Q000737:chemistry; D010777:Photochemistry; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000528:radiation effects; D013941:Thymine / Q000737:chemistry*
C521308:3'-(2-(3-benzoylphenyl)propanoyl)thymidine; C521307:5'-(2-(3-benzoylphenyl)propanoyl)thymidine; D001577:Benzophenones; D004988:Ethers, Cyclic; C047723:benzophenone; C005287:oxetane; D013941:Thymine; D013936:Thymidine