title: Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet.
abstract: Red wine is a beverage that can exert a broad spectrum of health-promoting actions both in humans and laboratory animal models if consumed moderately. However, information about its effect on body weight is scarce. We have evaluated the effect of moderate red wine consumption on body weight and energy intake in male Zucker lean rats fed a hypercaloric diet for 8 weeks. For this purpose, we used three 5-animal groups: a high-fat diet group (HFD), a high-fat-diet red-wine-drinking group (HFRWD), and a standard diet group (SD). After 8 weeks, the HFRWD group had a lower body weight gain (175.66 +/- 2.78% vs 188.22 +/- 4.83%; P<.05) and lower energy intake (269.45 +/- 4.02 KJ/animal.day vs day vs 300.81 +/- 4.52 KJ/animal.day; P<.05) and had less fat mass at epididymal location respect to the whole body weight (0.014 +/- 0.001 vs 0.017 +/- 0.001; P<.05) than the HFD group. However, the red wine didn't modified the fed efficiency 0.012 +/- 0.001 g/KJ for HFRWD group versus 0.013 +/- 0.001 g/KJ for the HFD one (P=.080). These findings, though preliminary, show that moderate red wine intake can prevent the increase of body weight by modulating energy intake in a rat diet-induced model of obesity.
authors.affiliation: Department of Biochemistry and Biotechnology, Unitat d'Enologia del Centre de Referència en Tecnologia dels Aliments de la Generalitat de Catalunya, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Vadillo
authors.forename: Montserrat Vadillo
authors.initials: MV
authors.lastname: Bargalló
authors.forename: Anna
authors.initials: A
authors.lastname: Ardévol
authors.forename: Anna Ardévol
authors.initials: AA
authors.lastname: Grau
authors.forename: Juan
authors.initials: J
authors.lastname: Fernández-Larrea
authors.forename: Juan de Dios
authors.initials: Jde D
authors.lastname: Fernández-Larrea
authors.forename: Gerard
authors.initials: G
authors.lastname: Pujadas
authors.forename: Gerard Pujadas
authors.initials: GP
authors.lastname: Anguiano
authors.forename: Cinta
authors.initials: C
authors.lastname: Bladé
authors.forename: Maria Cinta Bladé
authors.initials: MC
authors.lastname: Segarra
authors.forename: Maria Josepa
authors.initials: MJ
authors.lastname: Salvadó
authors.forename: Maria Josepa Salvadó
authors.initials: MJ
authors.lastname: Rovira
authors.forename: Lluís
authors.initials: L
authors.lastname: Arola
authors.forename: Lluia Arola
authors.initials: LA
authors.lastname: Ferré
authors.forename: Mayte
authors.initials: M
authors.lastname: Blay
authors.forename: Mayte Blay
authors.initials: MB
authors.lastname: Olivé
mesh_terms: D050154:Adiposity; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D004822:Epididymis; D008297:Male; D009765:Obesity / Q000209:etiology / Q000517:prevention & control; D051381:Rats; D011924:Rats, Zucker; D015430:Weight Gain; D014920:Wine
chemical_list: D004041:Dietary Fats