Effect of neuromedin S on feeding regulation in the Japanese quail.
Neuromedin S (NMS) was recently isolated from the brains of humans, mice and rats as an endogenous ligand for the orphan G protein-coupled receptors FM-3 and FM-4, which have been identified as neuromedin U (NMU) receptors 1 and 2, respectively. To investigate the role of NMS in avian species, we elucidated the effect of intracerebroventricular (i.c.v.) administration of rat NMS on food intake, body weight, body temperature and gross locomotor activity in adult Japanese quails. NMS significantly decreased food intake (and consequently body weight) in a time-dependent manner during 12-h light period, but increased both body temperature and gross locomotor activity. On the other hand, i.c.v. injection of rat NMU showed the reverse effects of NMS in Japanese quail. These results suggest that NMS may play an important role in regulating food intake and sympathetic nerve activity in the Japanese quail.
Shousha
Saad
S
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Gakuen-kibanadainishi 1-1, Miyazaki 889-2155, Japan.
Nakahara
Keiko
K
Sato
Miho
M
Mori
Kenji
K
Miyazato
Mikiya
M
Kangawa
Kenji
K
Murakami
Noboru
N
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology*; D003370:Coturnix / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000008:administration & dosage*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology
D009479:Neuropeptides; C497950:neuromedin S