C-reactive protein predicts death in patients with non-ischemic cardiomyopathy.
C-reactive protein (CRP) has been associated with atherosclerotic complications, and we hypothesized that CRP levels might also predict death in non-ischemic patients with left ventricular dysfunction. Two hundred and three patients with non-ischemic left ventricular dysfunction undergoing cardiac catheterization were included and were followed for 2.4 +/- 1.4 years to determine the incidence of fatal events. Death occurred in 15% of patients with low CRP (1st and 2nd tertiles) and 30% of patients with high CRP (3rd tertile). After adjustment for 11 covariates, high CRP (p = 0.037, hazard ratio = 2.0) significantly and independently predicted mortality. Even in the absence of coronary artery disease, patients with left ventricular dysfunction are at increased risk of mortality based on their baseline CRP concentrations.
Ronnow
Brianna S
BS
Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA.
Reyna
Sandra P
SP
Muhlestein
Joseph B
JB
Horne
Benjamin D
BD
Allen Maycock
Chloe A
CA
Bair
Tami L
TL
Carlquist
John F
JF
Kfoury
Abdallah G
AG
Anderson
Jeffrey L
JL
Renlund
Dale G
DG
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D009202:Cardiomyopathies / Q000097:blood* / Q000401:mortality* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000097:blood / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000097:blood* / Q000401:mortality* / Q000503:physiopathology; D016017:Odds Ratio; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D013318:Stroke Volume; D016019:Survival Analysis; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000401:mortality
D015415:Biomarkers; D002097:C-Reactive Protein