Effects of feed restriction on the nucleolar structure and function in lymphocytes.
Since malnutrition leads to adverse effects of several drugs on haemopoiesis and blood morphology, we tested if malnutrition itself could affect the nucleolar structure and function in rat lymphocytes. We report changes in the proportion of different nucleolar types that were dependent on the severity of feed restriction. The observed changes resemble those seen with cytostatics suggesting a possible link between feed restriction and haemotoxicity.
Berger
Josef
J
University of South Bohemia, Ceske Budejovice, Czech Republic. berger@jcu.cz
Machackova
Martina
M
Berger
Zdenek
Z
D000818:Animals; D002466:Cell Nucleolus / Q000473:pathology*; D005508:Food Deprivation; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D044342:Malnutrition; D018613:Microscopy, Confocal; D051381:Rats; D017208:Rats, Wistar