[The preparation and the in vitro release of OANO-1 microspheres].
OBJECTIVE
To prepare OANO-1 microspheres and test their release in vitro.


METHODS
OANO-1 microspheres were made by W/O/W-liquid drying process. The surface morphology of the microspheres was observed by SEM. The mean diameter and the size distribution of microspheres, the drug loading and the incorporation efficiency were examined. The release of OANO-1 microspheres in vitro was examined by small cup method. The accumulated release percent of OANO-1 microspheres was examined.


RESULTS
The OANO-1 microspheres were regular in their morphology. The average particle size was 8.59 microm with over 90% of the microspheres being in the range of 1-12 microm. The drug loading and the incorporation efficiency were 48.39% and 19.32% respectively. The accumulated release percent of OANO-1 microspheres was 78.4% after 108 h. The release half-life t1/2 was 40.8 h and Higuchi equation was Y = 0.1326 X - 0.4782, r = 0.9951.


CONCLUSIONS
The preparation of OANO-1 microspheres was well. The release in vitro of OANO-1 microspheres showed significant sustained release.
Yang
Fan
F
Guangdong College of Pharmacy, Guangzhou 510224, China. gzyangfan@21cn.com
Bi
Guo-wen
GW
Long
Xiao-ying
XY
Yu
Zhi-min
ZM
Yang
Wei-song
WS
Feng
Li-ping
LP
D029971:Angelica sinensis / Q000737:chemistry; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004338:Drug Combinations; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D034181:Epimedium / Q000737:chemistry; D005363:Ficusin / Q000032:analysis; D011564:Furocoumarins / Q000032:analysis; D008863:Microspheres; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry*; D029907:Psoralea / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; C011659:angelicin; D005363:Ficusin