Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes.
AhR, a ligand-activated transcription factor, mediates xenobiotic signaling to enhance the expression of target genes, including drug-metabolizing cytochrome P450s. The recent development of several new techniques, including chromatin immunoprecipitation and RNA interference, has expanded and deepened our knowledge of AhR function in the xenobiotic signal transduction. In this review, we briefly summarize our current understanding of the activation and inactivation of AhR activities and discuss the future directions of AhR research.
Fujii-Kuriyama
Y
Y
Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8577, Japan. ykfujii@tara.tsukuba.ac.jp
Mimura
J
J
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D004789:Enzyme Activation / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D018336:Receptors, Aryl Hydrocarbon / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics
D018336:Receptors, Aryl Hydrocarbon; D003577:Cytochrome P-450 Enzyme System