Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.
The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment.
Faenza
Irene
I
Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Italy.
Billi
Anna Maria
AM
Follo
Matilde Yung
MY
Fiume
Roberta
R
Martelli
Alberto Maria
AM
Cocco
Lucio
L
Manzoli
Lucia
L
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D002467:Cell Nucleus / Q000201:enzymology; D004789:Enzyme Activation; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism*; D032446:Myoblasts / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D054799:Phospholipase C beta; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism*
D007527:Isoenzymes; D010716:Phosphatidylinositols; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1; D010738:Type C Phospholipases; D054799:Phospholipase C beta