title: Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells.
abstract: Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin molecules, which were connected by a C-C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50values of 23.4, 22.9, 29.0, and 23.3 microM, respectively.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Dang Ngoc
authors.initials: DN
authors.lastname: Quang
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Chie
authors.initials: C
authors.lastname: Kohchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishizawa
authors.forename: Gen-Ichiro
authors.initials: G
authors.lastname: Soma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000818:Animals; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013057:Spectrum Analysis / Q000379:methods; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D013729:Terpenes; D009569:Nitric Oxide; C058858:grifolin