Preparation and characterization of ibuprofen pellets based on Eudragit RS PO and RL PO or their combination.
The aim of this study was to assess the application of Eudragit RL PO and RS PO and their combination for production of ibuprofen pellets by extrusion-spheronization. The pellets were prepared based on full factorial design. Independent variables were % ibuprofen (40, 60, 80), the ratio of Eudragit RS to Eudragit RL (1:0, 1:1, 0:1) and % PVP (1, 3, 5). The evaluated responses were mean dissolution time (MDT), crushing strength and elastic modulus of pellets. Surface characteristics, sphericity and aspect ratio of pellets were also evaluated. Linear regression and response surface modeling was used for analyzing results. It was shown that the amount of water required to prepare a proper wet mass was affected by composition of formulations. The required amount of water decreased with increasing drug load and percent of PVP. It was also shown that formulations containing Eudragit RL need more water. Increasing percent of PVP slightly decreased MDT and elastic modulus but had negligible effect on crushing strength. Increasing the percent of ibuprofen up to 60% decreased MDT but beyond that increased MDT. Increasing the percent of ibuprofen also decreased elastic modulus of pellets. Eudragit RL PO compare with Eudragit RS PO resulted in pellets with high crushing strength; however, Eudragit type did not have a significant effect on elastic modulus.
Abbaspour
M R
MR
School of Pharmacy and Pharmaceutical Research Centre, Vakilabad blvd., PO Box 91775-1365, Mashhad University of Medical Science, Mashhad, Iran. abbaspourmr@yahoo.com
Sadeghi
F
F
Garekani
H Afrasiabi
HA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006244:Hardness; D007052:Ibuprofen / Q000737:chemistry*; D016014:Linear Models; D008962:Models, Theoretical; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; C496966:Eudragit RSPO; D011108:Polymers; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); D014867:Water; C058665:Eudragit RL; D007052:Ibuprofen