title: Histological study on sinus lift grafting by Fisiograft and Bio-Oss.
abstract: The work aims to provide a histological investigation of Fisiograft, a PLA/PGA copolymer, used as filler for bone defects in humans. The study was performed on biopsies of sinus lifts where Bio-Oss and Fisiograft gel were applied as graft material. Bone regeneration was satisfactory in all sinus lifts, even when Fisiograft was applied alone. Due to remarkable osteoclast activity, Bio-Oss granules were cleared from the majority of biopsy cores. At histology, Fisiograft gel appeared as globes enveloped by fibroblasts, displaying an epithelial-like cell appearance. Due to its solubility in solvents, undegraded Fisiograft (recorded for 7 months or more) did not stain whereas degraded Fisiograft stained positive. The loose connective tissue, that surrounded Fisiograft and bone contained isolated mastocytes. Bone grew inside the loose connective and often reached the surface of Fisiograft by intervening cells. The results seem to indicate that Fisiograft may be considered both a polymer useful for fastening bone substitutes inside a defect and in addition a material capable of prompting bone regeneration, with or without the use of a bone substitute. In addition to space-former and space-maintainer functions, Fisiograft shows potential bone stimulation function, which may be labelled as osteopromotive capability.
authors.affiliation: Department of Anatomy and Histology, Human Anatomy Section, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Zaffe
authors.forename: G C
authors.initials: GC
authors.lastname: Leghissa
authors.forename: J
authors.initials: J
authors.lastname: Pradelli
authors.forename: A R
authors.initials: AR
authors.lastname: Botticelli
mesh_terms: D001345:Autoradiography; D001672:Biocompatible Materials; D001706:Biopsy; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D005500:Follow-Up Studies; D005782:Gels; D048091:Guided Tissue Regeneration; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D008407:Mast Cells / Q000166:cytology; D008443:Maxillary Sinus / Q000601:surgery; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D016348:Osseointegration; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D010012:Osteogenesis; D011098:Polyglactin 910 / Q000737:chemistry / Q000627:therapeutic use; D011100:Polyglycolic Acid / Q000737:chemistry / Q000627:therapeutic use; D011108:Polymers; D012995:Solubility; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D005782:Gels; D008903:Minerals; D011108:Polymers; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011098:Polyglactin 910