The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain.
Continuous exposure to extremely low-frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) alone and combined with D-amphetamine (1.5 mg/kg) affected the reduced glutathione content in brain regions of rats. Compared to sham-exposed rats, the glutathione content in the forebrain cortex of the ELF-MF-exposed rats decreased (P < 0.001), but this reverted after giving amphetamine upon ELF-MF exposure. In this group, the glutathione content was increased in the brain stem and cerebellum (P < 0.05 compared to the sham-exposed, ELM-MF-exposed, and amphetamine-treated groups). It is suggested that biogenic monoamines are involved in the reduced glutathione changes observed. The changes are not uniform in the brain regions examined.
Jelenković
Ankica
A
Institute for Biological Research Sinisa Stankovic, Belgrade, Serbia and Montenegro. aka950@yahoo.com
Janać
Branka
B
Pesić
Vesna
V
Jovanović
Marina D
MD
Vasiljević
Ivana
I
Prolić
Zlatko
Z
D000818:Animals; D015306:Biogenic Monoamines / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000502:physiology / Q000528:radiation effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D051381:Rats; D013997:Time Factors
D015306:Biogenic Monoamines; D000697:Central Nervous System Stimulants; D005978:Glutathione; D003913:Dextroamphetamine