Closer to the source: notch and the nature of thymus-settling cells.
Questions regarding T cell development have recently received much attention, but the earliest intrathymic differentiation steps in adult mice have remained controversial. Three new papers together show that for at least some thymus-settling precursors, the loss of B lineage potential occurs in the thymus, and Notch acts on multipotent progenitors early after thymic entry.
Zediak
Valerie P
VP
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Maillard
Ivan
I
Bhandoola
Avinash
A
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology / Q000276:immunology*; D051880:Receptors, Notch; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
D008565:Membrane Proteins; D051880:Receptors, Notch