[Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats].
This study sought to assess the effects of Quercetin and Enalapril on urinary protein excretion and amount of platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor-1 (VEGF-1) in renal tissue of diabetic rats. 29 streptozotocin-induced diabetic rats were divided into 3 groups, diabetic control group (group D, n=12); Enalapril group (group E, n=10); Quercetin group (group Q, n=7). In addition, there was one normal control group (group N, n = 5). The urinary protein excretion of 24 hours was measured at 4, 8, 12 weeks. All rats were sacrificed at 12 weeks. The amounts of PDGF-B and VEGF-1 in renal tissue were measured by immunohistochemical techniques. The 24-h levels of urinary protein excretion of D,Q and E groups were higher than that of N group; the level of Q, E groups were lower than that of D group; there was no difference between Q and E group. The expression levels of PDGF-B and VEGF-1 in renal tissue of D, Q, and E groups were significantly higher than that of N group the levels of Q and E groups were significantly lower than that of D group, no difference was found between Q and E group. The protective role of Quercetin and Enalapril in lowering urinary protein excretion may be related to the decreased amounts of PDGF-B and VEGF-1 in renal tissue.
Huang
Hui
H
Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
Fu
Jingyi
J
Tian
Haoming
H
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004656:Enalapril / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008297:Male; D011507:Proteinuria / Q000378:metabolism; D020574:Proto-Oncogene Proteins c-sis / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D020574:Proto-Oncogene Proteins c-sis; D042461:Vascular Endothelial Growth Factor A; D004656:Enalapril; D011794:Quercetin