title: The Gail model predicts breast cancer in women with suspicious radiographic lesions.
abstract: BACKGROUND
  We sought to evaluate whether a woman's 5-year Gail risk adds to the predictive value of the Breast Imaging Reporting and Data System (BI-RADS) classification for the detection of breast cancer.
  
  
  METHODS
  We performed a retrospective review of the BI-RADS classifications and pathology results for all image-guided needle breast biopsy examinations over a 3-year period at our institution. The 5-year Gail risk was calculated for eligible patients. Chi-square analysis was used to compare rates of malignancy based on Gail and BI-RADS scores.
  
  
  RESULTS
  A total of 632 image-guided needle biopsy examinations were performed in 609 women. A total of 414 women had suspicious (BI-RADS 4) lesions and underwent 424 biopsy examinations. For this subset, women with a Gail risk of less than 1.7% had 21% malignant results, whereas those with a Gail risk of 1.7% or greater had 42% malignant results (relative risk, 1.94; 95% confidence interval, 1.45-2.66).
  
  
  CONCLUSIONS
  The Gail model can stratify further the risk for breast cancer in women with suspicious breast imaging reports.
authors.affiliation: Department of Surgery, Loma Linda University Medical Center, 11175 Campus St., Suite 21111, Loma Linda, CA 92354, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Weik
authors.forename: Sharon S
authors.initials: SS
authors.lastname: Lum
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Esquivel
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Tully
authors.forename: Won C
authors.initials: WC
authors.lastname: Bae
authors.forename: Floyd F
authors.initials: FF
authors.lastname: Petersen
authors.forename: Jenny M
authors.initials: JM
authors.lastname: Jaque
authors.forename: Mark E
authors.initials: ME
authors.lastname: Reeves
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Garberoglio
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D016217:Ultrasonography, Mammary