title: Serodiagnosis of mycoses using recombinant antigens.
abstract: The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtain, they usually show low reproducibility and are not very specific, since antibodies from patients with different mycoses may show cross-reactivity. The application of molecular biology techniques to the study of fungal antigens has allowed the production of recombinant antigens that may help to solve these problems. The purpose of this review is to discuss the use of recombinant fungal antigens in the diagnosis of mycoses.
authors.affiliation: Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao, Vizcaya, Spain. oibelven@lg.ehu.es
authors.forename: Natalia
authors.initials: N
authors.lastname: Elguezabal
authors.forename: Fernando
authors.initials: F
authors.lastname: Lopitz-Otsoa
authors.forename: Ana
authors.initials: A
authors.lastname: Laín
authors.forename: Iñigo Fernández
authors.initials: IF
authors.lastname: de Larrinoa
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Moragues
authors.forename: José
authors.initials: J
authors.lastname: Pontón
mesh_terms: D000946:Antigens, Fungal / Q000235:genetics; D005658:Fungi / Q000145:classification / Q000276:immunology*; D006801:Humans; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology; D011994:Recombinant Proteins / Q000235:genetics; D012698:Serologic Tests
chemical_list: D000946:Antigens, Fungal; D011994:Recombinant Proteins