title: Oligopeptides as catalysts for asymmetric epoxidation.
abstract: Oligopeptides are versatile catalysts for the enantioselective epoxidation of electron deficient alkenes, (e.g. alpha,beta-unsaturated ketones) with alkaline hydrogen peroxide. This review describes optimisation of the catalyst, substrate range, synthetic applications of the products and rationalisation of the stereoselectivity by an active site model.
authors.affiliation: The Tatem Laboratories, School of Chemistry, Cardiff University, Cardiff, CF10 3AT, Wales, United Kingdom. KellyDR@Cardiff.ac.uk
authors.forename: David R
authors.initials: DR
authors.lastname: Kelly
authors.forename: Stanley M
authors.initials: SM
authors.lastname: Roberts
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002599:Chalcone / Q000737:chemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D004852:Epoxy Compounds; D009842:Oligopeptides; D002599:Chalcone; D006861:Hydrogen Peroxide