[Candida albicans isolated from buccal cavity of children with Down's syndrome: occurrence and growth inhibition by Streptomyces sp].
Comparison of the presence of Candida yeasts in the buccal cavity of children without and with Down's syndrome showed a statistically significant difference in the case of children that were affected by this chromosomopathy, rendering them more predisposed to buccal candidiasis, probably due to anatomicophysiologic alterations of the mouth resulting from trisomy of chromosome 21. Constant recurrence of buccal candidiasis in children with this chromosomal alteration lead to the search for a possible therapeutic alternative. Seeking to determine the antifungal activity of Streptomyces sp isolated from various Brazilian soils, 5 strains have been tested for Candida albicans isolated from the buccal cavity of children with Down's syndrome. It was observed that the isolate presented a diversity in the size of the halos (9-31 mm in diameter) of growth inhibition of the yeasts, suggesting a possible use as a therapeutic antifungal.
Vieira
José Daniel Gonçalves
JD
Departamento de Microbiologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO. jvieira@iptsp.ufg.br
Ribeiro
Evandro Leão
EL
Campos
Cerise de Castro
Cde C
Pimenta
Fabiana Cristina
FC
Toledo
Orlando Ayrton de
OA
Nagato
Gustavo Morais
GM
Souza
Niwmar Alves de
NA
Ferreira
Wesley Magno
WM
Cardoso
Cléver Gomes
CG
Dias
Sueli Meira da Silva
SM
Araújo Júnior
César Aparício de
CA
Zatta
Daniel Teles
DT
Santos
Juliana de Sousa dos
Jde S
D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003140:Communicable Disease Control / Q000379:methods; D004314:Down Syndrome / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012463:Saliva / Q000382:microbiology; D013302:Streptomyces / Q000502:physiology*