NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice.
The nuclear transcription factor of activated T cells (NFAT) suggested to be a tumor suppressor. Here we report that two out of three NFATc3-/- and two in four NFATc3 +/- female mice developed aggressive mammary adenocarcinoma by 12.5 and 16 mo of age, respectively, with no occurrences in age-matched wild-type littermates (N-14). Thus, our data suggest that NFATc3 can suppress the development of mammary gland tumors in female mice.
Lee
Hoyun
H
Northeastern Ontario Regional Cancer Centre, Sudbury, Ontario, Canada.
Chouinard
Luc
L
Bonin
Michel
M
Michel
Robin N
RN
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D002471:Cell Transformation, Neoplastic; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D051379:Mice; D018345:Mice, Knockout; D050778:NFATC Transcription Factors / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism*
D050778:NFATC Transcription Factors; C445503:transcription factor NF-AT c3