title: Invasive pulmonary aspergillosis transformed into fatal mucous impaction by immune reconstitution in an AIDS patient.
abstract: Reported here is the case of a newly diagnosed AIDS patient with end-stage HIV infection and biopsy-proven invasive pulmonary aspergillosis who responded to antifungal therapy but developed severe mucous impaction in association with rapid immune restoration that was ultimately fatal. Invasive pulmonary aspergillosis complicates about 4% of AIDS infections. A search of the medical literature revealed no previous report of this organism's involvement in immune restoration syndrome.
authors.affiliation: Education and Research Centre, Wythenshawe University Hospital, Southmoor Road, Manchester, M23 9LT, UK.
authors.forename: H
authors.initials: H
authors.lastname: Sambatakou
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D001232:Aspergillus fumigatus; D017809:Fatal Outcome; D006801:Humans; D007121:Immunocompetence; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents