title: Hemodynamic and vascular effects of ventricular sourcing by stent-based ventricle to coronary artery bypass in patients with multivessel disease undergoing coronary artery bypass surgery.
abstract: BACKGROUND
  The hemodynamic and vascular effects of ventricular sourcing by a stent-based (VSTENT, Percardia) left ventricle-to-coronary artery bypass were studied in a patient subgroup of the European multicenter ADVANTAGE study (ADjunctive treatment with the VCAB/VSTENT myocardial implANT system in coronary Artery bypass Graft patiEnts).
  
  
  RESULTS
  Twelve patients who underwent VSTENT implantation in addition to coronary artery bypass surgery were studied up to 12 months after the procedure. The VSTENT was implanted distal to a hemodynamically relevant coronary artery stenosis. Coronary flow velocity was assessed at rest and during dobutamine stress. Intraoperative VSTENT implantation was successful in 11 of 12 patients. Early postoperative angiograms showed patent VSTENT in 8 of 11 patients, with predominantly systolic flow distal to the VSTENT. Coronary flow velocity reserve induced by dobutamine stress was 1.7+/-0.1 (P=0.006). VSTENT patency at 2- to 6-month follow-up was present in 5 of 11 patients, with concomitant VSTENT stenosis in 4 of those 5. In all patients, coronary flow velocity increased 3- to 4-fold proximal to the VSTENT, which was associated with a moderate degree of arterial remodeling. Except for target vessel reintervention (n=5), no other major adverse events were observed in 11 of 12 patients. One patient died on the second postoperative day, though the cause was probably not related to the VSTENT implantation.
  
  
  CONCLUSIONS
  VSTENT implantation seems to be safe in the mid-term follow-up and leads to a predominantly systolic coronary flow pattern in the vessel supplied by the VSTENT, with a flow reserve similar or close to that seen with conventional bypass. VSTENT patency rate, however, was unacceptably low at 3- to 6-month follow-up and needs to be improved.
authors.affiliation: Department of Internal Medicine, Grosshadern University Hospital, Munich, Germany. boekstegers@med1.med.uni-muenchen.de
authors.forename: Peter
authors.initials: P
authors.lastname: Boekstegers
authors.forename: Philip
authors.initials: P
authors.lastname: Raake
authors.forename: Rabea
authors.initials: R
authors.lastname: Hinkel
authors.forename: Tilmann
authors.initials: T
authors.lastname: Pohl
authors.forename: Christian
authors.initials: C
authors.lastname: Kupatt
authors.forename: Andreas
authors.initials: A
authors.lastname: Knez
authors.forename: Frank
authors.initials: F
authors.lastname: Christ
authors.forename: Sandra
authors.initials: S
authors.lastname: Eifert
authors.forename: Gerhard
authors.initials: G
authors.lastname: Steinbeck
authors.forename: Bruno
authors.initials: B
authors.lastname: Reichart
authors.forename: Calin
authors.initials: C
authors.lastname: Vicol
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods*; D003326:Coronary Circulation; D025401:Echocardiography, Stress; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000453:epidemiology; D006352:Heart Ventricles / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D016896:Treatment Outcome