title: Extracorporeal membrane oxygenation with lepirudin anticoagulation for Wegener's granulomatosis with heparin-induced thrombocytopenia.
abstract: Venovenous extracorporeal membrane oxygenation with lepirudin anticoagulation was successfully used for a complicated case of Wegener's granulomatosis and heparin-induced thrombocytopenia. Interestingly, a linear correlation was found between activated partial thromboplastin time and activated clotting time during lepirudin anticoagulation.
authors.affiliation: Department of ECMO and Cardiac Surgery, Glenfield Hospital, Groby Road, Leicester, United Kingdom.
authors.forename: Sendhil K
authors.initials: SK
authors.lastname: Balasubramanian
authors.forename: Ravindranath
authors.initials: R
authors.lastname: Tiruvoipati
authors.forename: Shimonti
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Andrew
authors.initials: A
authors.lastname: Sosnowski
authors.forename: Richard K
authors.initials: RK
authors.lastname: Firmin
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000473:pathology; D006493:Heparin; D006629:Hirudins; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011994:Recombinant Proteins / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000628:therapy; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; C083544:lepirudin