Sleep during concanavalin-A-induced hepatitis and peritonitis in inbred mice.
OBJECTIVE
To assess the suitability of concanavalin-A-induced hepatitis as a model for investigating the relationships between hepatic disease and alterations in somnolence.


METHODS
We characterized the sleep patterns of various strains of inbred mice undergoing ConA-induced inflammation.


METHODS
Southern Illinois University School of Medicine, Springfield, IL.


METHODS
Intravenous or intraperitoneal administration of concanavalin-A.


METHODS
Inbred mice.


RESULTS
Intravenous and intraperitoneal administration of concanavalin-A both elicited strain-dependent changes in slow-wave sleep. ConA treatment also reduced spontaneous locomotor activity. ConA-induced changes in slow-wave sleep varied with dose, route of administration, and circadian period of administration. As compared with the other strains, C57BL/6J mice had lower serum concentrations of interferon-gamma at 8 hours after ConA administration.


CONCLUSIONS
These data provide the first demonstration that sleep enhancement and reduced locomotor activity accompany hepatic inflammation in mice.
Toth
Linda A
LA
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62794-9611, USA. ltoth@siumed.edu
Hughes
Larry F
LF
Rehg
Jerold E
JE
D000818:Animals; D001831:Body Temperature; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003208:Concanavalin A / Q000008:administration & dosage / Q000009:adverse effects*; D007275:Injections, Intravenous; D007371:Interferon-gamma / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008124:Locomotion; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010538:Peritonitis / Q000139:chemically induced*; D012895:Sleep, REM / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D007371:Interferon-gamma