Molecular regulation of microlymphatic formation and function: role of nitric oxide.
Inhibition of lymphangiogenesis prevents lymphatic cancer metastasis, whereas induction of lymphangiogenesis alleviates lymphedema in experimental animal models. The number of known molecular players that govern the formation and function of the microlymphatic system is growing. Here, we review the role of nitric oxide within the regulation of lymphatic formation and function and point out key unanswered questions for its translation into clinical therapy.
Hagendoorn
Jeroen
J
E.L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Padera
Timothy P
TP
Fukumura
Dai
D
Jain
Rakesh K
RK
D000818:Animals; D006801:Humans; D042583:Lymphangiogenesis / Q000502:physiology; D008208:Lymphatic System / Q000254:growth & development / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*
D009569:Nitric Oxide