title: [Serious clinical course of myocarditis with "apical ballooning": first presentation of pathogenicity of HHV6 subtype A in myocarditis].
abstract: We report of a 67 year-old female who has suffered a flu-like infection three days ago and presented with symptoms of acute coronary syndrome. Coronary heart disease could be excluded. The ventriculography showed a moderate reduced left ventricular function characterized by "apical ballooning". Endomyocardial biopsies and EDTA blood gave a direct proof of human herpes virus 6 subtype A. Histological and immunohistochemical analysis revealed a myocarditis with areas of interstitial macrophages and fibrosis. This case presents for the first time the cross-link of myocarditis with HHV6A infection and the appearance of "apical ballooning".
authors.affiliation: Medizinische Klinik III, Eberhard-Karls-Universität Tübingen. boris.bigalke@med.uni-tuebingen.de
authors.forename: B
authors.initials: B
authors.lastname: Bigalke
authors.forename: K
authors.initials: K
authors.lastname: Klingel
authors.forename: A E
authors.initials: AE
authors.lastname: May
authors.forename: M
authors.initials: M
authors.lastname: Beyer
authors.forename: T
authors.initials: T
authors.lastname: Hövelborn
authors.forename: R
authors.initials: R
authors.lastname: Kandolf
authors.forename: M
authors.initials: M
authors.lastname: Gawaz
mesh_terms: D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D009205:Myocarditis / Q000150:complications / Q000175:diagnosis*; D019349:Roseolovirus Infections / Q000150:complications / Q000175:diagnosis*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology