Endogenous superantigens shape response to exogenous superantigens.
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vbeta8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vbeta8(+) T cells, was significantly reduced and conferred protection from superantigen-induced mortality.
Rajagopalan
Govindarajan
G
Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, SW, Rochester, MN 55905, USA.
Singh
Manisha
M
Sen
Moon M
MM
Murali
Narayana S
NS
Nath
Karl A
KA
David
Chella S
CS
D000818:Animals; D004768:Enterotoxins / Q000276:immunology* / Q000494:pharmacology; D015802:HLA-DR2 Antigen / Q000235:genetics / Q000276:immunology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D018089:Superantigens / Q000276:immunology* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D004768:Enterotoxins; D015802:HLA-DR2 Antigen; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens; C031818:enterotoxin B, staphylococcal