title: [Vestibular paroxysmia: clinical study and treatment of eight patients].
abstract: Vestibular paroxysmia is a syndrome of cross-compression of the VIII cranial nerve and was first described by Jannetta who used the term "disabling positional vertigo". This syndrome is characterized by brief attacks of vertigo, tinnitus, vestibular and auditory deficits. MRI may show the VIII nerve compression from vessels in the posterior fossa, such as the basilar, vertebral, anterior-inferior cerebellar or the posterior-inferior cerebellar arteries. Vestibular paroxysmia may be treated either with medical therapy, such as carbamazepine, phenytoin or gabapentin or with the microvascular decompression of the VIII nerve. This study describes eight patients with vestibular paroxysmia. Four of them showed also clinical signs suggesting cross-compression of the V and/or VII nerve. Seven patients treated with carbamazepine had significant improvement of vertigo and tinnitus.
authors.affiliation: Serviço de Neurologia, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil. kozoroski@terra.com.br
authors.forename: Aline Mizuta Kozoroski
authors.initials: AM
authors.lastname: Kanashiro
authors.forename: Paula Levatti
authors.initials: PL
authors.lastname: Alexandre
authors.forename: Cristiana Borges
authors.initials: CB
authors.lastname: Pereira
authors.forename: Antonio Carlos de Paiva
authors.initials: AC
authors.lastname: Melo
authors.forename: Milberto
authors.initials: M
authors.lastname: Scaff
mesh_terms: D000368:Aged; D000588:Amines / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D005260:Female; D000077206:Gabapentin; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000175:diagnosis* / Q000188:drug therapy; D012189:Retrospective Studies; D014012:Tinnitus / Q000175:diagnosis* / Q000188:drug therapy; D014717:Vertigo / Q000175:diagnosis* / Q000188:drug therapy; D000159:Vestibulocochlear Nerve; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
chemical_list: D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin