Synergistic potential of ceftazidime plus amikacin or levofloxacin against Pseudomonas aeruginosa as determined using a checkerboard and a disk diffusion technique.
The synergistic potential of ceftazidime plus amikacin or levofloxacin was assessed against 61 Pseudomonas aeruginosa isolates with variable susceptibility patterns to the 3 antibiotics. A checkerboard broth method and a disk diffusion method were used and compared. The latter, also easy to perform as a triple-disk assay, could be a helpful laboratory screening tool for drug synergism to drive possible combination treatments.
Montanari
Maria Pia
MP
Institute of Microbiology and Biomedical Sciences, Marche Polytechnic University Medical School, 60131 Ancona, Italy.
Piccoli
Laura
L
Mingoia
Marina
M
Marchetti
Federico
F
Varaldo
Pietro Emanuele
PE
D000583:Amikacin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005779:Immunodiffusion / Q000379:methods; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000890:Anti-Infective Agents; D064704:Levofloxacin; D000583:Amikacin; D002442:Ceftazidime; D015242:Ofloxacin