Limited influences of chemotherapy on healthy and metastatic liver parenchyma.
OBJECTIVE
To examine the expression of E-cadherin, beta-catenin, gamma-catenin, VEGF, and p53 in 39 patients with hepatic metastasis from colorectal cancer immunohistochemically.


METHODS
The patients were divided into two groups: those (n = 16) who had no chemotherapy for at least 6 mo before the liver resections and those (n = 23) who were treated with chemotherapy before liver resections. A score from 0 to 3 was given for the number of positive cells and from 0 to 3 for the intensity of staining in these cells, in both healthy and metastatic liver parenchyma.


RESULTS
No significant differences in the expression of E-cadherin, beta- and gamma-catenin, VEGF and p53, could be observed between patients who received and did not receive chemotherapy, in both normal and metastatic liver parenchyma.


CONCLUSIONS
Despite the assumption that chemotherapy had an effect on liver metastasis, no influences were noticed immunohistochemically.
Van Damme
Nancy
N
Department of Gastroenterology, Ghent University Hospital, De Pintelaan 185, 1K12IE, Ghent 9000, Belgium. nancy.vandamme@ugent.be
Demetter
Pieter
P
De Bock
Wouter
W
Rottiers
Marianne
M
Praet
Marleen
M
de Hemptinne
Bernard
B
Peeters
Marc
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies