Synthesis of (-)-amphidinolide K fragment C9-C22.
[reaction: see text] The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (-)-amphidinolide K (1) has been achieved from synthons C9-C14 (3) and C15-C22 (4), which have both been prepared from glutamic acid in good overall yields.
Andreou
Thanos
T
Departament de Química Orgànica, Facultat de Química, Av. Diagonal 647, Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain.
Costa
Anna M
AM
Esteban
Laia
L
Gonzàlez
Lluïsa
L
Mas
Gemma
G
Vilarrasa
Jaume
J
D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D000097442:Amphidinolides
D018942:Macrolides; C409107:amphidinolide K; D000097442:Amphidinolides