title: Randomized, multicenter trial of conventional ventilation versus high-frequency oscillatory ventilation for the early management of respiratory failure in term or near-term infants in Colombia.
abstract: OBJECTIVE
  To determine the efficacy and safety of high-frequency oscillatory ventilation (HFOV) compared to conventional ventilation (CV) for the treatment of respiratory failure in term and near-term infants in Colombia.
  
  
  METHODS
  Eligible infants with moderate to severe respiratory failure were randomized to early treatment with CV or HFOV. Ventilator management and general patient care were standardized. The main outcome was neonatal death or pulmonary air leak.
  
  
  RESULTS
  A total of 119 infants were enrolled (55 in the HFOV group; 64 in the CV group) during the study period. Six infants in the HFOV group (11%) and two infants in the CV group (3%) developed the primary outcome (RR: 3.6, 95% CI: 0.8-16.9). Five infants in the HFOV group (9%) and one infant in the CV (2%) died before 28 days of life (RR: 5.9 CI: 0.7-48.2). Secondary outcomes were similar between groups.
  
  
  CONCLUSIONS
  HFOV may not be superior to CV as an early treatment for respiratory failure in this age group. Standardization of ventilator management and general patient care may have a greater impact on the outcome in Colombia than mode of ventilation.
authors.affiliation: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232-2370, USA.
authors.forename: Mario A
authors.initials: MA
authors.lastname: Rojas
authors.forename: Juan M
authors.initials: JM
authors.lastname: Lozano
authors.forename: María X
authors.initials: MX
authors.lastname: Rojas
authors.forename: Carl L
authors.initials: CL
authors.lastname: Bose
authors.forename: Martín A
authors.initials: MA
authors.lastname: Rondón
authors.forename: Gloria
authors.initials: G
authors.lastname: Ruiz
authors.forename: Juan G
authors.initials: JG
authors.lastname: Piñeros
authors.forename: Catherine
authors.initials: C
authors.lastname: Rojas
authors.forename: Guillermo
authors.initials: G
authors.lastname: Robayo
authors.forename: Angela
authors.initials: A
authors.lastname: Hoyos
authors.forename: Luz Astrid
authors.initials: LA
authors.lastname: Celis
authors.forename: Sergio
authors.initials: S
authors.lastname: Torres
authors.forename: Janet
authors.initials: J
authors.lastname: Correa
mesh_terms: D006612:High-Frequency Ventilation; D006801:Humans; D007223:Infant; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000628:therapy*; D016896:Treatment Outcome