title: Synthesis and SAR of highly selective MMP-13 inhibitors.
abstract: The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
authors.affiliation: Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA. JCLI@wyeth.com
authors.forename: Jianchang
authors.initials: J
authors.lastname: Li
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Rush
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Dianne
authors.initials: D
authors.lastname: DeVincentis
authors.forename: Xuemei
authors.initials: X
authors.lastname: Du
authors.forename: Yonghan
authors.initials: Y
authors.lastname: Hu
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Thomason
authors.forename: Jason S
authors.initials: JS
authors.lastname: Xiang
authors.forename: Jerauld S
authors.initials: JS
authors.lastname: Skotnicki
authors.forename: Steve
authors.initials: S
authors.lastname: Tam
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Cunningham
authors.forename: Priya S
authors.initials: PS
authors.lastname: Chockalingam
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Morris
authors.forename: Jeremy I
authors.initials: JI
authors.lastname: Levin
mesh_terms: D000586:Amination; D001572:Benzofurans / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017364:Collagenases / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry
chemical_list: D001572:Benzofurans; D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D013455:Sulfur; D017364:Collagenases; D053509:Matrix Metalloproteinase 13