Simultaneous bilateral spontaneous pneumothorax observed during the administration of gefitinib for lung adenocarcinoma with multiple lung metastases.
A 41-year-old man with productive cough was admitted to our hospital. His chest roentgenogram showed multiple small nodules in the bilateral lung fields. The nodules were revealed as intrapulmonary metastases of the adenocarcinoma of the lung. Systemic chemotherapy with paclitaxel and carboplatin was not effective, and continuous oral gefitinib therapy was initiated. Twenty-one days later, spontaneous pneumothorax was found in the left lung, and four days after that, in the right lung as well. The extent of the pneumothorax was slight; therefore, he recovered without drainage within several days. Spontaneous pneumothorax, especially bilateral pneumothorax, is a rare complication of chemotherapy for lung cancer.
Mori
Masahide
M
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
Nakagawa
Masaru
M
Fujikawa
Takeya
T
Iwasaki
Takeo
T
Kawamura
Tomoko
T
Namba
Yoshinobu
Y
Niinaka
Manabu
M
Takeda
Yoshito
Y
Kimura
Hiromi
H
Naka
Nobuyuki
N
Okada
Tatsuya
T
Yamaguchi
Toshihiko
T
Yokota
Soichiro
S
Ito
Masami
M
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000284:Administration, Oral; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D011030:Pneumothorax / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011799:Quinazolines / Q000008:administration & dosage / Q000009:adverse effects*; D011859:Radiography
D000970:Antineoplastic Agents; D011799:Quinazolines; D000077156:Gefitinib