title: Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment.
abstract: Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ventilator-associated lung injury was believed to result from the use of high pressure, thus, the term barotraumas. This trauma is believed to involve free-radical damage. Oxidant injury is a serious cause of lung injury. In the present study, 110 newborns with respiratory distress syndrome were studied; 55 were treated with melatonin and the other 55 with placebo. All the subjects were mechanically ventilated with or without guaranteed volume. Proinflammatory cytokines [interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-alpha] were measured in tracheobronchial aspirate and the clinical outcome was evaluated. Melatonin treatment reduced the proinflammatory cytokines and improved the clinical outcome. The beneficial action of melatonin presumably related to its antioxidative actions.
authors.affiliation: Institute of Medical Pediatrics, Neonatal Intensive Care Unit, University of Messina, Messina, Italy.
authors.forename: Eloisa
authors.initials: E
authors.lastname: Gitto
authors.forename: Russel J
authors.initials: RJ
authors.lastname: Reiter
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sabatino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Buonocore
authors.forename: Carmelo
authors.initials: C
authors.lastname: Romeo
authors.forename: Placido
authors.initials: P
authors.lastname: Gitto
authors.forename: Concetta
authors.initials: C
authors.lastname: Buggé
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Trimarchi
authors.forename: Ignazio
authors.initials: I
authors.lastname: Barberi
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000097:blood; D008550:Melatonin / Q000627:therapeutic use*; D010100:Oxygen / Q000378:metabolism; D011175:Positive-Pressure Respiration; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D008550:Melatonin; D010100:Oxygen