Antimycins A10 approximately A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893.
Seven new antimycin antibiotics, named antimycins A10, A11, A12, A13, A14, A15 and A16, were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A1, A2, A3 and A4. The structures of the new antimycins were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited antifungal activity against Candida utilis.
Hosotani
Nobuo
N
Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co Ltd, 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan. hosotani@sumitomopharm.co.jp
Kumagai
Kazuo
K
Nakagawa
Hiroyuki
H
Shimatani
Takuro
T
Saji
Ikutaro
I
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000968:Antimycin A / Q000031:analogs & derivatives*; D002175:Candida / Q000187:drug effects; D005285:Fermentation; D015394:Molecular Structure; D013302:Streptomyces / Q000145:classification*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000968:Antimycin A