title: [Experimental study on xue-bao capsules against injury of radiation or cyclophosphamide in mice].
abstract: OBJECTIVE
  To explore the effects of xue-bao capsules on injury of radio-or chemo-therapy in mice, in order to provide rationale behind clinical trials.
  
  
  METHODS
  xue-xu (deficiency of blood) model in mice was induced by radiation or cyclophosphamide. Leucocyte (WBC), erythrocyte (RBC), hemoglobin (Hb) and platelet (Pt) in peripheral blood as well as CFU-E and CFU-Gm in bone marrow were counted.
  
  
  RESULTS
  CFU-E and CFU-Gm in normal mice were promoted by this drug. The reduction of WBC, RBC and Hb in peripheral blood as well as CFU-E and CFU-Gm in bone marrow owing to the 3.5 Gy of 60Co radiation were antagonized by the drug. It had also antagonized cyclophosphamide induced the reduction of WBC, RBC and Pt in peripheral blood.
  
  
  CONCLUSIONS
  xue-bao capsules has the effects against the adverse reactions of radio-or-chemo-therapy.
authors.affiliation: Shanxi Provincial Institute for Drug Control, Taiyuan 030001, China. gaotianhong@126.com
authors.forename: Tian-Hong
authors.initials: TH
authors.lastname: Gao
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Piao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D002214:Capsules; D002452:Cell Count; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000633:toxicity; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004906:Erythrocyte Count; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D042381:Granulocyte Precursor Cells / Q000187:drug effects / Q000528:radiation effects; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D010976:Platelet Count; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000473:pathology*; D011897:Random Allocation; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide