title: Intellectual prognosis of status epilepticus in adult epilepsy patients: analysis with Wechsler Adult Intelligence Scale-revised.
abstract: OBJECTIVE
  Status epilepticus (SE) appears to cause cognitive dysfunction as well as other serious neurologic sequelae. To confirm whether SE produces a subsequent intellectual decline, we evaluated intellectual function prospectively in adult epilepsy patients with and without SE.
  
  
  METHODS
  Of 1,685 patients with epilepsy who underwent comprehensive neuropsychological testing in two national hospitals in Japan, 15 patients experienced an episode of SE afterward and underwent the second neuropsychological examination after the SE episode. Forty clinically matched patients with epilepsy, but without an episode of SE since their initial neuropsychological examination, were also reevaluated. We compared IQs and subscores from the Wechsler Adult Intelligence Scale-Revised between the two groups by repeated measures analysis of variance. In the patients who experienced an SE episode, SE-related variables (i.e., age at the SE episode and type and duration of SE) and epilepsy-related variables such as epilepsy type, lateralization of EEG abnormalities, the presence of mesial temporal sclerosis, and previous history of SE, were evaluated in relation to intellectual outcome.
  
  
  RESULTS
  Patients with SE, in comparison to those without SE, failed to show any significant post-SE intellectual decline. Furthermore, neither the SE-related variables nor the clinical characteristics were correlated with intellectual outcome.
  
  
  CONCLUSIONS
  Our findings suggest that SE does not lead to a significant intellectual decline in adult patients receiving treatment for epilepsy.
authors.affiliation: Adachi Mental Clinic, Sapporo, Japan. adacchan@tky2.3web.ne.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Adachi
authors.forename: Kousuke
authors.initials: K
authors.lastname: Kanemoto
authors.forename: Reimi
authors.initials: R
authors.lastname: Muramatsu
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kato
authors.forename: Nozomi
authors.initials: N
authors.lastname: Akanuma
authors.forename: Masumi
authors.initials: M
authors.lastname: Ito
authors.forename: Jun
authors.initials: J
authors.lastname: Kawasaki
authors.forename: Teiichi
authors.initials: T
authors.lastname: Onuma
mesh_terms: D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis*; D015897:Comorbidity; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D005260:Female; D007839:Functional Laterality / Q000145:classification; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012598:Sclerosis / Q000473:pathology; D013226:Status Epilepticus / Q000175:diagnosis* / Q000453:epidemiology; D014888:Wechsler Scales / Q000706:statistics & numerical data*
chemical_list: D000927:Anticonvulsants