Hyper-IgE syndrome with widespread premalign oral papillomas treated with interferon alpha2b.
We report a case of a 7-year-old girl with hyperimmunoglobulin-E syndrome presenting with widespread oral papillomas which were tested for human papilloma virus DNA and had shown to be at high/intermediate risk group for malignancy. She had elevated levels of IgE, recurrent sinopulmonary infections, atopic-like dermatitis, peripheral eosinophilia and defective neutrophil chemotaxis. Interferon alfa 2b therapy and chemoprophylaxis with sulfamethoxazole-trimethoprim was given. Although the papillomas partially improved with the treatment, sinopulmonary infections continue to occur.
Ozarmağan
Güzin
G
Department of Dermatology, Istanbul University, Istanbul Medical Facility, Turkey. gozarmagan@mailcity.com
Didem Yazganoğlu
Kurtulus
K
Agaçfidan
Ali
A
D002648:Child; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007589:Job Syndrome / Q000150:complications*; D009059:Mouth Diseases / Q000150:complications / Q000188:drug therapy*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000188:drug therapy*; D011230:Precancerous Conditions / Q000150:complications*; D011994:Recombinant Proteins; D014860:Warts / Q000150:complications
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins