title: An audit of the use of magnesium sulphate in severe pre-eclampsia and eclampsia.
abstract: Over the last decade there has been an increase in the use of MgSO4 for the prevention of seizures in women with severe pre-eclampsia or eclampsia. At the Rotunda Hospital it is regularly used for this purpose. The aim of this study was to audit the use of MgSO4 at the hospital, to determine whether the drug was being used according to the hospital's protocol and to observe its effectiveness in the prevention of eclampsia in our population. A retrospective chart review over the two years from 1/1/2000 to 31/12/2001 was undertaken. Outcome measures assessed were; Patient selection, Administration of the drug - whether recommended protocols were adhered, Effectiveness of therapy for seizure prophylaxis, Maternal and neonatal outcomes. There were 12,910 deliveries at the Rotunda hospital over this period of time. Fifty of these women were treated with MgSO4 (0.4%). Patient selection was appropriate in all cases. The correct loading dose of MgSO4 was administered in all cases, however MgSO4 levels were recorded in only 30 (60%) of women. There were no seizures in the treated group. Two women presented with seizures (one was antenatal the other post-natal period), both were treated with MgSO4. There were no maternal or neonatal mortality. Seventy two percent (36) of these women were delivered by lower segment caesarean section. The mean gestation at delivery was 36 weeks (range 28-41 weeks). Thirty eight percent (13) of babies required admission to the neonatal intensive care unit. The mean birth weight at delivery was 2.54 kg (range 1.11-3.68 kg). MgSO4 use in the Rotunda hospital appears to be safe and effective for the prevention of seizures in women with severe pre-eclampsia or eclampsia. Serum MgSO4 levels were only recorded in 60% of patients and the hospital's protocol was not adhered to regarding monitoring of patients on treatment. This needs to be addressed.
authors.affiliation: The Rotunda Hospital, Dublin, Ireland. docjo_ie@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: O'Donovan
authors.forename: S D
authors.initials: SD
authors.lastname: Coulter-Smith
authors.forename: M
authors.initials: M
authors.lastname: Geary
mesh_terms: D000293:Adolescent; D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D004461:Eclampsia / Q000150:complications*; D005260:Female; D006761:Hospitals; D006801:Humans; D007494:Ireland; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008485:Medical Audit; D011225:Pre-Eclampsia / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*
chemical_list: D008278:Magnesium Sulfate