title: [Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].
abstract: Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine. Hyperactivity of xanthineoxidase and POL content were also revealed. The close correlation relation of purine indices of such patients has been observed. The obtained data allow applying methods of correction of immunity system and purine metabolism to these patients by introducing in a complex therapy inhibitors of xanthineoxidase.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Nikolenko
authors.forename: O V
authors.initials: OV
authors.lastname: Siniachenko
authors.forename: M N
authors.initials: MN
authors.lastname: Anan'eva
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Nikolenko
authors.forename: V V
authors.initials: VV
authors.lastname: Dubiaga
authors.forename: I N
authors.initials: IN
authors.lastname: Shchukin
mesh_terms: D000596:Amino Acids / Q000097:blood* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000378:metabolism*; D006073:Gout / Q000097:blood / Q000150:complications / Q000378:metabolism*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D008054:Lipid Peroxides / Q000097:blood; D011687:Purines / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
chemical_list: D000596:Amino Acids; D008054:Lipid Peroxides; D011687:Purines; D014527:Uric Acid; D014969:Xanthine Oxidase; C030985:purine