Synthesis of cationic porphyrin modified amino acids.
Derivatives of amino acids bearing a porphyrin moiety on a side chain were synthesized by coupling a porphyrin to a glutamic acid side chain; the utility of these compounds was demonstrated by their use in solid-phase synthesis of a peptide bearing a cationic porphyrin and by studying its DNA-binding properties.
Biron
Eric
E
Département de chimie and CREFSIP, Faculté des sciences et de génie, Université Laval, Québec, Québec, Canada G1K 7P4.
Voyer
Normand
N
D000596:Amino Acids / Q000138:chemical synthesis*; D020029:Base Pairing; D002412:Cations; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D002412:Cations; D007202:Indicators and Reagents; D010455:Peptides; D011166:Porphyrins; D018698:Glutamic Acid; D004247:DNA