title: Glial fibrillary acidic protein is expressed in the aged rat olfactory epithelium.
abstract: CONCLUSIONS
  Our findings suggest that the aging process induces changes in the phenotype of olfactory supporting cells in the rat.
  
  
  OBJECTIVE
  To investigate age-related changes in the expression of astroglial intermediate filament proteins in the olfactory supporting cells of the rat.
  
  
  METHODS
  The expression of nestin and glial fibrillary acidic protein (GFAP) in the olfactory epithelium (OE) of young (3 months) and aged (25 months) Sprague-Dawley rats was compared using Western blotting and immunohistochemistry.
  
  
  RESULTS
  Western blot analysis showed nestin expression only in the young OE, whereas GFAP was detected only in the aged OE. Immunohistochemistry showed that GFAP was localized in the olfactory supporting cells of the aged OE, with regional differences.
authors.affiliation: Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Bum Sun
authors.initials: BS
authors.lastname: Kwon
authors.forename: Kyeung Min
authors.initials: KM
authors.lastname: Joo
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Pyo
authors.forename: Young Hee
authors.initials: YH
authors.lastname: Cheon
authors.forename: Tai-Kyong
authors.initials: TK
authors.lastname: Baik
authors.forename: Choong Ik
authors.initials: CI
authors.lastname: Cha
authors.forename: Sa Sun
authors.initials: SS
authors.lastname: Cho
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Nam
authors.forename: Byung Lan
authors.initials: BL
authors.lastname: Lee
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D015153:Blotting, Western; D004847:Epithelial Cells / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D064231:Nestin; D009831:Olfactory Mucosa / Q000378:metabolism*; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin