Newly detected specific hydrogenation of the conjugated double bond of unsaturated alkaloid lactones by Aspergillus sp.
A new isolate of Aspergillus sp. hydrogenated the gamma,delta-double bond of securinine (143 mg l(-1)) to give 14,15-dihydrosecurinine at over 98% (w/w) yield after 8 h. It also hydrogenated the C11(13) double bond of 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6-olide-2-one (HGT) (200 mg l(-1)) to give 3-hydroxy-1(10),3-guaiadiene-12,6-olide-2-one with over 98% (w/w) conversion after 24 h.
Guan
Hong
H
Department of Biology & Chemistry, Shenyang Pharmaceutical University, 110016, Shenyang, PR China.
You
Song
S
Yang
Li
L
Wang
Xu
X
Ni
Rui
R
D000470:Alkaloids / Q000378:metabolism*; D001230:Aspergillus / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism*; D001381:Azepines / Q000378:metabolism; D006576:Heterocyclic Compounds, 4 or More Rings / Q000378:metabolism; D006572:Heterocyclic Compounds, Bridged-Ring; D006859:Hydrogen / Q000378:metabolism*; D006860:Hydrogen Bonding; D006865:Hydrogenation; D007783:Lactones / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism; D013045:Species Specificity
D000470:Alkaloids; D001381:Azepines; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; D006859:Hydrogen; C000785:securinine