1,25-dihydroxyvitamin D suppresses circulating levels of parathyroid hormone in a patient with primary hyperparathyroidism and coexistent sarcoidosis.
BACKGROUND
PTH is excessively secreted to develop hypercalcemia and accelerate bone turnover in patients with primary hyperparathyroidism. PTH stimulates the production of 1,25-dihydroxyvitamin D [1,25(OH)2D] that in turn suppresses the synthesis of PTH in parathyroid cells.


OBJECTIVE
The objective of the study was to clarify whether 1,25(OH)2D indeed inhibits circulating levels of PTH and influences bone turnover, even in a patient with primary hyperparathyroidism.


METHODS
We evaluated PTH levels in a patient with primary hyperparathyroidism and coexistent sarcoidosis whose serum 1,25(OH)2D levels were independent of PTH.


METHODS
The present case was treated with prednisolone before and after surgical resection of parathyroid adenoma, and Ca-regulating hormones and bone markers were measured.


RESULTS
Serum Ca and PTH levels significantly decreased after parathyroid surgery, whereas serum 1,25(OH)2D levels remained high. Prednisolone administration promptly decreased serum 1,25(OH)2D levels and reciprocally increased PTH levels despite consistent serum Ca levels either before or after surgery. PTH levels were negatively correlated with serum 1,25(OH)2D levels before and after surgery. Urine N-telopeptides, serum osteocalcin, and bone-type alkaline phosphatase all decreased to physiological ranges after parathyroid surgery.


CONCLUSIONS
These results suggest that 1,25(OH)2D indeed inhibits the production of PTH not to exacerbate hypercalcemia in a patient with primary hyperparathyroidism. Furthermore, PTH but not 1,25(OH)2D may primarily be involved in the stimulation of bone turnover.
Kinoshita
Yuka
Y
Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon Minato-ku, Tokyo 105-8470, Japan.
Taguchi
Manabu
M
Takeshita
Akira
A
Miura
Daishu
D
Tomikawa
Shinji
S
Takeuchi
Yasuhiro
Y
D000368:Aged; D015415:Biomarkers; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D009994:Osmolar Concentration; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors* / Q000097:blood*; D012507:Sarcoidosis / Q000150:complications*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism
D015415:Biomarkers; D006728:Hormones; D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium