title: Hemolytic characteristics of three commercially available centrifugal blood pumps.
abstract: OBJECTIVE
  As compared with traditional extracorporeal roller-occlusion blood pumps, nonocclusive centrifugal pumps offer the benefits of requiring a smaller circuit surface area and, thus, a smaller prime volume. However, centrifugal blood pumps have been reported to generate unacceptable levels of hemolysis. We hypothesize that the newer generation centrifugal pumps have an incidence of hemolysis similar to the traditional roller head pumps and, thus, could be used for extracorporeal membrane oxygenation circuits.
  
  
  METHODS
  Randomized, prospective, bench study.
  
  
  METHODS
  University research laboratory.
  
  
  METHODS
  Three centrifugal blood pumps (Cobe Revolution, Jostra Rotaflow, and Medtronic BioMedicus) were compared with a roller occlusion blood pump (Cobe Century). Hemolysis generation was examined during 6 hrs of continuous use. Two test runs per group were randomly performed on three consecutive days for a total of six test runs for each of the four pumps (n = 24).
  
  
  RESULTS
  Plasma free hemoglobin values were determined using a Spectra MaxPlus spectrophotometer. A normalized index of hemolysis was calculated to compare the individual trials. The Cobe Revolution and the Jostra Rotaflow compared favorably with the Cobe Century roller occlusion blood pump in the amount of hemolysis produced.
  
  
  CONCLUSIONS
  These data are encouraging for the development of a low-prime, mobile neonatal extracorporeal membrane oxygenation circuit using centrifugal pump technology.
authors.affiliation: Department of Perfusion Services, Duke University Health System, Durham, NC, USA.
authors.forename: D Scott
authors.initials: DS
authors.lastname: Lawson
authors.forename: Richard
authors.initials: R
authors.lastname: Ing
authors.forename: Ira M
authors.initials: IM
authors.lastname: Cheifetz
authors.forename: Rich
authors.initials: R
authors.lastname: Walczak
authors.forename: Damian
authors.initials: D
authors.lastname: Craig
authors.forename: Scott
authors.initials: S
authors.lastname: Schulman
authors.forename: Frank
authors.initials: F
authors.lastname: Kern
authors.forename: Ian R
authors.initials: IR
authors.lastname: Shearer
authors.forename: Andrew
authors.initials: A
authors.lastname: Lodge
authors.forename: James
authors.initials: J
authors.lastname: Jaggers
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002417:Cattle; D002498:Centrifugation; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D066298:In Vitro Techniques; D013997:Time Factors
chemical_list: D006454:Hemoglobins