title: Echocardiographic features and brain natriuretic peptides in patients presenting with heart failure and preserved systolic function.
abstract: OBJECTIVE
  To characterise patients who appear to fulfil the diagnosis of heart failure with preserved systolic function clinically, echocardiographically, and by concentrations of brain-type natriuretic peptide (BNP).
  
  
  METHODS
  102 new cases of heart failure were identified over 24 months in 213 patients referred to a rapid access heart failure clinic. Patients with heart failure and preserved systolic function with contemporary markers of diastolic function were assessed to evaluate their cardiac status further.
  
  
  RESULTS
  Forty patients (39%) had an ejection fraction (EF) < 45% and 62 (61%) had an EF > or = 45%. Of these 62 patients, 30 (48%) fulfilled the case definition of diastolic heart failure. The remaining 32 (52%) had neither an EF < 45% nor abnormalities of diastolic function. Dobutamine stress echocardiography was performed on 26 (42%) patients with EF > or = 45%, which provided an alternative explanation for symptoms in 15 (58%) patients. Concentrations of BNP were higher in patients with diastolic abnormalities (mean (SEM) 101.4 (32.5) pg/ml v 58.4 (6.78) pg/ml, p = 0.042) and with no diastolic abnormalities (199 (37.9) pg/ml v 58.4 (6.78) pg/ml, p < 0.0001) than in patients with no heart failure.
  
  
  CONCLUSIONS
  Among ambulatory patients presenting with suspected heart failure in the community 19% have systolic dysfunction, 14% have diastolic dysfunction, and 15% seemingly have heart failure with neither systolic nor diastolic dysfunction. A new understanding, including alternative parameters of diastolic function, seems to be necessary to classify patients with heart failure and preserved systolic function.
authors.affiliation: Cardiovascular Medicine, National Heart and Lung Institute, Imperial College, London, UK. thomasmd@globalnet.co.uk
authors.forename: M D
authors.initials: MD
authors.lastname: Thomas
authors.forename: K F
authors.initials: KF
authors.lastname: Fox
authors.forename: D A
authors.initials: DA
authors.lastname: Wood
authors.forename: J S R
authors.initials: JS
authors.lastname: Gibbs
authors.forename: A J S
authors.initials: AJ
authors.lastname: Coats
authors.forename: M Y
authors.initials: MY
authors.lastname: Henein
authors.forename: P A
authors.initials: PA
authors.lastname: Poole-Wilson
authors.forename: G C
authors.initials: GC
authors.lastname: Sutton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002303:Cardiac Output, Low / Q000175:diagnosis* / Q000000981:diagnostic imaging; D025401:Echocardiography, Stress; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010865:Pilot Projects; D013318:Stroke Volume; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000000981:diagnostic imaging
chemical_list: D020097:Natriuretic Peptide, Brain