title: Adenocarcinoma arising in a vaginal müllerian cyst: a case report.
abstract: BACKGROUND
  We report a case of adenocarcinoma arising in a vaginal müllerian cyst. Although the most common pathological type of vaginal cysts is müllerian cyst, malignant change of a müllerian cyst has not been reported before.
  
  
  METHODS
  A 48-year-old woman presented with a 3 cm-sized ruptured vaginal cyst. The cyst had been asymptomatic for 20 years, but ruptured 2 months before her visit. After the diagnosis of atypical glands was made on punch biopsy of cyst wall, she underwent an operative excision and the final histopathologic examination revealed an adenocarcinoma arising in the müllerian cyst. After the surgery, she received a course of external radiation therapy followed by brachytherapy. At 6 months following treatment, the patient remained without evidence of disease.
  
  
  CONCLUSIONS
  To our knowledge, this is the first case report of an adenocarcinoma arising from a müllerian cyst. The possibility of malignant transformation should be considered and careful follow-up is warranted even in cases of asymptomatic vaginal cysts.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, and Center for Uterine Cancer, National Cancer Center, Gyeonggi-do, South Korea.
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Lee
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Park
authors.forename: Sun
authors.initials: S
authors.lastname: Lee
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Seo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D003560:Cysts / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009095:Mullerian Ducts / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*