title: White matter fiber tractography via anisotropic diffusion simulation in the human brain.
abstract: A novel approach to noninvasively tracing brain white matter fiber tracts is presented using diffusion tensor magnetic resonance imaging (DT-MRI). This technique is based on successive anisotropic diffusion simulations over the human brain, which are utilized to construct three dimensional diffusion fronts. The fiber pathways are determined by evaluating the distance and orientation from the fronts to their corresponding diffusion seeds. Synthetic and real DT-MRI data are employed to demonstrate the tracking scheme. It is shown that the synthetic tracts are accurately replicated, and several major white matter fiber pathways can be reproduced noninvasively, with the tract branching being allowed. Since simulating the diffusion process, which is truly a physical phenomenon reflecting the underlying architecture of cerebral tissues, makes full use of the diffusion tensor data, including both the magnitude and orientation information, the proposed approach is expected to enhance robustness and reliability in white matter fiber reconstruction.
authors.affiliation: Department of Computer Science, University of Kentucky, Lexington, KY 40506-0046, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Kang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Eric S
authors.initials: ES
authors.lastname: Carlson
authors.forename: Daniel
authors.initials: D
authors.lastname: Gembris
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D001185:Artificial Intelligence; D001921:Brain / Q000166:cytology*; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009434:Neural Pathways / Q000166:cytology*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity