title: Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects.
abstract: This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson.
authors.affiliation: Neuroscience Comportementale et Psychopharmacologie, University of Liège, Belgium. equertemont@ulg.ac.be
authors.forename: Etienne
authors.initials: E
authors.lastname: Quertemont
authors.forename: C J Peter
authors.initials: CJ
authors.lastname: Eriksson
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Zimatkin
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Pronko
authors.forename: Marco
authors.initials: M
authors.lastname: Diana
authors.forename: Milena
authors.initials: M
authors.lastname: Pisano
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Rodd
authors.forename: Richard R
authors.initials: RR
authors.lastname: Bell
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Ward
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D009042:Motivation; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011355:Prodrugs / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism
chemical_list: D011355:Prodrugs; D011954:Receptors, Dopamine; D000431:Ethanol; D000079:Acetaldehyde