title: Preparation and biocompatibility of novel UV-curable chitosan derivatives.
abstract: UV-curable chitosans (UVCC-7-10) were synthesized using less-toxic agents. The UVCC-7 was completely cured by UV spot irradiation for 4 s. The UVCC-7 was implanted into murine subcutaneous tissues, and the response to the implantation was observed by histological examination at 7 days after implantation. In the histological findings, the implant was surrounded by thin fibrous granulating tissue with no inflammatory cellular infiltration. Fibroblasts infiltrate between the cured implant. The novel synthesized UVCC-7 showed good biocompatibility.
authors.affiliation: Department of Clinical Veterinary Medicine, Tottori University, 4-101 Koyma-Minami, Tottori 680-8553, Japan.
authors.forename: Eiko
authors.initials: E
authors.lastname: Renbutsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Hirose
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Omura
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Nakatsubo
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Okamura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shigemasa
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002240:Carbohydrate Sequence; D048271:Chitosan / Q000737:chemistry*; D003487:Cyanoacrylates / Q000737:chemistry / Q000494:pharmacology; D004817:Epidermis / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D020007:Implants, Experimental; D007249:Inflammation; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000378:metabolism; D011897:Random Allocation; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D000447:Aldehydes; D001672:Biocompatible Materials; D003487:Cyanoacrylates; D048271:Chitosan