title: [Study of 12 epidemical cases of legionnaire's disease occurred in Meurthe-et-Moselle (France) between July and August 2004].
abstract: METHODS
  To describe epidemiological, clinical, biological, radiological data and therapeutic features of legionnaire's disease during an outbreak occurring in Meurthe-et-Moselle between July-August 2004.
  
  
  RESULTS
  12 cases were recorded including 11 men, 6 smokers, 4 alcoholo-nicotinic, 3 diabetics, 3 with hemopathy, 1 with corticotherapy; in one case no risks factors were found; mean age was 68.5 years [minimum=48; maximum=96]. Nine cases had sudden symptoms. Nine cases had a fever up to 40 degrees C, 9 with dyspnoea, 7 with cough, 7 with a relative bradycardia, 3 with diarrhoea, 3 felt faint, 3 with confusion. Radiology: unilateral unilobe localisation in 10 cases. Biological data: cytolysis in 8 cases, CRP >300 mg/l in 8. The diagnosis confirmed with urinary antigen of Legionella pneumophila serogroup 1 (UrAgLp1) in 12 cases. In 2 cases, UrAgLp1 appeared negative between 3rd and 10th day after the beginning of a treatment although UrAgLp1 was positive before the treatment. In all cases, the first serology realised during first days following occurrence the first symptoms remained negative. Two serology of control in four were positive. One search of L. pneumophila serogroup 1 in sputum was positive in 7. Bitherapy was used in 7 cases with preferential association: fluoroquinolone+rifampicin. Two patients died. Origin of the contamination remains unknown.
  
  
  CONCLUSIONS
  Culture of Legionella is essential, in epidemic context, to compare clinical and environmental Legionella and to locate the origin of contamination.
authors.affiliation: Département de maladies infectieuses et tropicales, Tour Drouet, hôpitaux de Brabois, rue du Morvan, 54500 Vandoeuvre-lès-Nancy, France.
authors.forename: F
authors.initials: F
authors.lastname: Duhoux
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: S
authors.initials: S
authors.lastname: Bevilacqua
authors.forename: C
authors.initials: C
authors.lastname: Lion
authors.forename: P
authors.initials: P
authors.lastname: Hartemann
authors.forename: E
authors.initials: E
authors.lastname: Piquet
authors.forename: C
authors.initials: C
authors.lastname: Rabaud
authors.forename: T
authors.initials: T
authors.lastname: May
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D016952:Legionella pneumophila / Q000302:isolation & purification; D007877:Legionnaires' Disease / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged