title: Botulinum toxin for treatment of cocontractions related to obstetrical brachial plexopathy.
abstract: Botulinum toxin type A was recently introduced for treatment of biceps-triceps muscle cocontraction, which compromises elbow function in children with obstetrical brachial plexopathy. This is our preliminary experience with this new approach. Eight children were treated with 2-3 U/kg of botulinum toxin injected in the triceps (4 patients) and biceps (4 patients) muscle, divided in 2 or 3 sites. All patients submitted to triceps injections showed a long-lasting improvement of active elbow flexion and none required new injections, after a follow-up of 3 to 18 months. Three of the patients submitted to biceps injections showed some improvement of elbow extension, but none developed anti-gravitational strength for elbow extension and the effect lasted only three to five months. One patient showed no response to triceps injections. Our data suggest that botulinum toxin can be useful in some children that have persistent disability secondary to obstetrical brachial plexopathy.
authors.affiliation: Department of Neurology, University of São Paulo Medical School, São Paulo, SP, Brazil. carlos.heise@fleury.com.br
authors.forename: Carlos O
authors.initials: CO
authors.lastname: Heise
authors.forename: Lilian R
authors.initials: LR
authors.lastname: Gonçalves
authors.forename: Egberto R
authors.initials: ER
authors.lastname: Barbosa
authors.forename: Jose Luiz D
authors.initials: JL
authors.lastname: Gherpelli
mesh_terms: D001720:Birth Injuries / Q000150:complications*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D020516:Brachial Plexus Neuropathies / Q000188:drug therapy* / Q000209:etiology; D002675:Child, Preschool; D004551:Elbow Joint / Q000187:drug effects; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A