title: Use of paired serum samples for serodiagnosis of typhoid fever.
abstract: Using an enzyme-linked immunosorbent assay we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serological test based on the detection of anti-lipopolysaccharide immunoglobulin G is increased when used with paired serum samples taken 1 week apart.
authors.affiliation: Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, South Kensington, UK. d.house@ic.ac.uk
authors.forename: Deborah
authors.initials: D
authors.lastname: House
authors.forename: Nguyen T
authors.initials: NT
authors.lastname: Chinh
authors.forename: To S
authors.initials: TS
authors.lastname: Diep
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Parry
authors.forename: John
authors.initials: J
authors.lastname: Wain
authors.forename: Gordon
authors.initials: G
authors.lastname: Dougan
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Tran Tinh
authors.initials: TT
authors.lastname: Hien
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Farrar
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008070:Lipopolysaccharides / Q000276:immunology*; D012485:Salmonella typhi / Q000276:immunology; D012698:Serologic Tests; D013997:Time Factors; D014435:Typhoid Fever / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D008070:Lipopolysaccharides