[Mechanisms of action of LB-plaferon and fenovin in the cases of Rausche virus leukemia].
The aim of our investigation was to examine the mechanisms of protective features of plaferon LB and fenovit in mice infected with Rausche virus. It was found that in erythroblasts from peripheral blood and spleen, which appeared 12-14 days after infection, the highest percent of determined virus antigens was approximately 47% (range 35,5 to 58,4) which was followed by decrease of the concentration of virus antigens (between 5-12%) in following days and increase of uninfected cells as a result of division of non-contaminated erythroblasts. Mechanism of action of plaferon LB and fenovit was manifested in the reconstitution of mechanisms of apoptosis among erythroblasts, which did not contain synthesized Rausche virus. Impairment of functional activity and antivirus resistance of macrophagal phagocytes are playing an important role not only in the pathogenesis of murine viral leukemia caused by Rausche virus, but also during human leukemia. Correction of functional status of above -- mentioned diseases using plaferon LB and fenovit is presenting as a new and prospective way.
Mikeladze
R B
RB
Kupradze
S A
SA
Korsantiia
B M
BM
D000818:Animals; D005503:Food Additives / Q000494:pharmacology* / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009479:Neuropeptides / Q000494:pharmacology* / Q000627:therapeutic use*; D010586:Phagocytes / Q000378:metabolism*; D011925:Rauscher Virus; D012192:Retroviridae Infections / Q000150:complications / Q000188:drug therapy*; D014412:Tumor Virus Infections / Q000150:complications / Q000188:drug therapy*
D005503:Food Additives; D007155:Immunologic Factors; D009479:Neuropeptides; C091912:plaferon