[Hepatoprotective effects of Gentiana scabra on the acute liver injuries in mice].
OBJECTIVE
To study the hepatoprotective effect of the aerial parts and the roots of G. scabra on cute liver injury models.


METHODS
Acute liver injury models were induced by CCl4, TAA and D-GlanN in mice, and the levels of serum enzyme ALT, AST and AKP on acute liver injury mice with extracts of theaerial parts and the roots of G. scabra were determined.


RESULTS
Different dosages of theaerial part extract could significantly reduce the levels of serum enzyme ALT, AST and AKP (P < 0.05) on CCl4 and TAA model mice, but the serum enzymes reduction of D-GlanN model mice was not remarkably.


CONCLUSIONS
The methanolic extracts of the aerial parts and the roots of G. scabra both have certain hepatoprotective effects on acute liver injury models, and so the aerial parts of G. scabra can be used as the succedaneumm of G. scabra roots.
Jiang
Wei-Xin
WX
Pharmaceutical College, Harbin University of Commerce, Harbin 150076, China.
Xue
Bao-Yu
BY
D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005688:Galactosamine; D030012:Gentiana / Q000737:chemistry; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013853:Thioacetamide
D004365:Drugs, Chinese Herbal; D013853:Thioacetamide; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase