In vitro protein binding of teicoplanin to neonatal serum.
The protein-binding ability of teicoplanin (TEIC) to neonatal serum was investigated and the following results were obtained. (1) The protein binding ability of TEIC at concentrations ranging from 10 to 100 microg/ml, to neonatal serum was 80.5%-71.9% and was generally low as compared with that for adult serum. (2) The protein binding ability of TEIC (20 microg/ml) to albumin in neonatal serum was not concentration-dependent, and the correlation between the protein-binding ability and albumin concentration was low. Namely, it was suggested that the protein-binding ability of TEIC to neonatal serum was not dependent merely on the albumin concentration, and there was a possibility that the protein-binding ability also depended on qualitative changes in albumin. (3) The protein-binding ability of TEIC (20 microg/ml) to total bilirubin and free bilirubin was not concentration-dependent, and the correlation was extremely low, indicating that there is a low possibility that the protein-binding ability of TEIC induces an increase in free bilirubin.
Sando
Mitsuru
M
Department of Pharmacy, Ota General Hospital, Fuji Heavy Industries Ltd. Health Insurance Society, 29-5 Hachimancho, Ota, Gunma, 373-8585, Japan.
Sato
Yoshitake
Y
Iwata
Satoshi
S
Akita
Hironobu
H
Sunakawa
Keisuke
K
D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood*; D001663:Bilirubin / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007231:Infant, Newborn; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D017334:Teicoplanin / Q000097:blood*
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D012709:Serum Albumin; D017334:Teicoplanin; D001663:Bilirubin