Low concentrations of nitric oxide exert a hormetic effect on Mycobacterium tuberculosis in vitro.
Susceptibilities of 12 clinical Mycobacterium tuberculosis isolates to acidified sodium nitrite (ASN) were compared. The results demonstrate that 8 of the 12 isolates exhibited enhanced survival levels in 1.5 mM ASN compared to levels in medium alone, suggesting that low concentrations of reactive nitrogen intermediates have a hormetic effect on M. tuberculosis in vitro.
Brugmann
William Benjamin
WB
Louisiana State University Health Sciences Center, School of Allied Health Professions, Department of Clinical Laboratory Sciences, New Orleans, 70112-2223, USA.
Firmani
Marcia A
MA
D015169:Colony Count, Microbial; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D009569:Nitric Oxide / Q000494:pharmacology*; D026361:Reactive Nitrogen Species / Q000494:pharmacology; D012977:Sodium Nitrite / Q000494:pharmacology; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
D003470:Culture Media; D026361:Reactive Nitrogen Species; D009569:Nitric Oxide; D012977:Sodium Nitrite