Bone marrow transplantation as a strategy for the treatment of autoimmune hearing loss in MRL/Mp-lpr/lpr mice.
Sensorineural hearing loss (SNHL) has been reported to develop as a main part of or in combination with systemic and organ-specific autoimmune diseases. The aim of the current study is to treat autoimmune SNHL in MRL/Mp-lpr/lpr (MRL/lpr) mice, a murine model of systemic autoimmune disease, using allogeneic bone marrow transplantation (BMT), which replaces recipient bone marrow cells with bone marrow cells from a non-autoimmune-prone donor. The results indicate that BMT can be used to treat SNHL; cochlear pathology, serum autoantibodies and lupus nephritis are ameliorated. Therefore, it is conceivable that the autoimmune SNHL in the MRL/lpr mice results not from defects in the cochlea, including the stria vascularis, but from defects in the bone marrow, and BMT would therefore provide a curative effect on inner ear autoimmune dysfunction associated with systemic autoimmune diseases.
Iwai
Hiroshi
H
Department of Otolaryngology, Rakusai New Town Hospital, Kansai Medical University, Kyoto, Japan.
Lee
Shinryu
S
Inaba
Muneo
M
Baba
Susumu
S
Yamashita
Toshio
T
Ikehara
Susumu
S
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001323:Autoantibodies / Q000378:metabolism; D001327:Autoimmune Diseases / Q000601:surgery*; D016026:Bone Marrow Transplantation / Q000379:methods*; D003051:Cochlea / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D004277:DNA, Single-Stranded / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006319:Hearing Loss, Sensorineural / Q000235:genetics / Q000601:surgery*; D007074:Immunoglobulin G / Q000276:immunology; D007150:Immunohistochemistry / Q000379:methods; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D019463:Mice, Inbred MRL lpr / Q000601:surgery; D012097:Repressor Proteins / Q000097:blood; D012217:Rheumatoid Factor / Q000378:metabolism; D013997:Time Factors; D014184:Transplantation, Homologous / Q000379:methods
D001323:Autoantibodies; C498611:Cic protein, mouse; D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D012097:Repressor Proteins; D012217:Rheumatoid Factor