The bone marrow vascular niche: home of HSC differentiation and mobilization.
The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.
Kopp
Hans-Georg
HG
Weill Medical College of Cornell University, New York, New York, USA.
Avecilla
Scott T
ST
Hooper
Andrea T
AT
Rafii
Shahin
S
D000818:Animals; D001808:Blood Vessels / Q000502:physiology; D001853:Bone Marrow / Q000098:blood supply*; D002454:Cell Differentiation; D002465:Cell Movement; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D018919:Neovascularization, Physiologic / Q000502:physiology