title: [Prospective benefit and effect of lipiodol marking in hepatocellular carcinoma].
abstract: OBJECTIVE
  To assess the benefit and the effect of intraarterial lipiodol application on histological analysis of patients suspected of having HCC. To determine whether lipiodol marking leads to a better biopsy result and how lipiodol or a transarterial chemoembolization influences the histological diagnosis.
  
  
  METHODS
  Two groups of patients were examined. Group A included 14 patients highly suspected of having an HCC which had previously been unsuccessfully biopsied. A transarterial embolization with lipiodol was performed in these patients to mark intrahepatic tumors which could not otherwise be defined in unenhanced CT. A biopsy was then repeated. Group B included 22 patients undergoing therapy using transarterial chemoembolization (TACE). A biopsy was performed to support the diagnosis of a multifocal HCC before changing the therapy.
  
  
  RESULTS
  The transversal diameters of the biopsied tumors were similar in both groups (A: 22 mm; B: 21 mm). The length of percutaneous access was 71 mm in Group A and 88 mm in Group B. In eleven of 14 patients of Group A we confirmed the diagnosis of an HCC. Thirty-six procedures were necessary for this confirmation. In Group B we confirmed the diagnosis in 17 of 22 patients. In addition, we found typical histological modification due to hepatic cirrhosis and virus hepatitis. Lipiodol had no negative influence on the histological diagnosis.
  
  
  CONCLUSIONS
  Applying lipiodol for marking and delineating HCC-suspicious liver tumors in cases of formerly negative histology seems to enhance the success of biopsy, confirming the diagnosis of an HCC.
authors.affiliation: Klinik und Poliklinik für Radiologie, Klinikum der Johannes Gutenberg-Universität Mainz. gerhards@radiologie.klinik.uni-mainz.de
authors.forename: A
authors.initials: A
authors.lastname: Gerhards
authors.forename: P
authors.initials: P
authors.lastname: Mildenberger
authors.forename: S
authors.initials: S
authors.lastname: Herber
authors.forename: H A
authors.initials: HA
authors.lastname: Lehr
authors.forename: M
authors.initials: M
authors.lastname: Thelen
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology*; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007459:Iodized Oil; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D007459:Iodized Oil