Changes of plasma vascular endothelial growth factor level after uterine artery embolisation for leiomyomata.
Uterine artery embolisation (UAE) has become an alternative treatment for symptomatic uterine leiomyomata. Most reports suggest that it is well tolerated and effective, although there have been no reports of studies of biological parameters after UAE. In this study, we analysed the plasma level of vascular endothelial growth factor (VEGF) and the pulsatility index (PI) of uterine arteries before and after UAE. The level of plasma VEGF increased significantly after UAE (on day 1 and day 3) and decreased on day 7, and then increased again on day 30. The level of VEGF reached a peak value within three days after UAE. A significant inverse correlation was found between uterine artery PI and the level of VEGF on day 30, suggesting that VEGF may have negative effect on the efficacy of treatment of uterine leiomyomata by UAE.
Takeda
Takashi
T
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, Japan.
Osuga
Keigo
K
Morishige
Ken-ichirou
K
Tasaka
Keiichi
K
Nakamura
Hironobu
H
Murata
Yuji
Y
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000628:therapy*; D008875:Middle Aged; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000097:blood / Q000628:therapy*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A