The role of hepatitis C virus (HCV) in mitochondrial DNA damage in HIV/HCV-coinfected individuals.
Oxidative stress accompanying hepatitis C virus (HCV) infection seems to result in mitochondrial (mt) dysfunction. In HIV/HCV-coinfected individuals, HCV-related mt damage could be further enhanced and clinical manifestations of mt damage may appear, particularly following exposure to some antiretroviral drugs. Furthermore, when HCV medications are used together with certain antiretrovirals, the risk of developing mt adverse events may be particularly frequent, such as development of pancreatitis when ribavirin and didanosine are coadministered. The management of HIV/HCV-coinfected individuals needs to consider the high risk of mitochondria-associated toxicities in this population, which may significantly influence treatment decisions and therapeutic modalities.
de Mendoza
Carmen
C
Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
Soriano
Vincent
V
D000140:Acidosis, Lactic / Q000209:etiology; D019380:Anti-HIV Agents / Q000009:adverse effects; D000998:Antiviral Agents / Q000009:adverse effects; D004249:DNA Damage; D004272:DNA, Mitochondrial / Q000032:analysis*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D039682:HIV-Associated Lipodystrophy Syndrome / Q000209:etiology; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000187:drug effects
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D004272:DNA, Mitochondrial; D019344:Lactic Acid