Stem cell transplantation for autoimmune diseases.
Hematopoietic stem cell transplantation is an increasingly used therapy for treatment of autoimmune diseases and severe immune-mediated disorders. We address some general concepts and principles in the development of hematopoietic stem cell transplantation in order to understand the principles and design of safe autologous and allogeneic transplant regimens for these unique diseases.
Burt
Richard K
RK
Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA. rburt@nwu.edu
Verda
Larissa
L
Statkute
Laisvyde
L
Quigley
Kathleen
K
Yaung
Kimberly
K
Brush
Mary
M
Oyama
Yu
Y
D000074323:Alemtuzumab; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology / Q000601:surgery*; D002986:Clinical Trials as Topic; D000075202:Contraindications; D004195:Disease Models, Animal; D000939:Epitopes; D005544:Forecasting; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000639:trends; D006801:Humans; D007107:Immune System / Q000276:immunology; D051379:Mice; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D000939:Epitopes; D000074323:Alemtuzumab