title: Toward the synthesis of spirastrellolide A: construction of two C1-C25 diastereomers containing the BC-spiroacetal.
abstract: [reaction: see text] Stereo-controlled syntheses of two possible C1-C25 diastereomers of spirastrellolide A containing the cis-disubstituted tetrahydropyran and [6,6]-spiroacetal are reported, exploiting boron-mediated asymmetric aldol and allylation methodology.
authors.affiliation: University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Edward A
authors.initials: EA
authors.lastname: Anderson
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Dalby
authors.forename: Olivier
authors.initials: O
authors.lastname: Loiseleur
mesh_terms: D000080:Acetals / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013141:Spiro Compounds; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D018942:Macrolides; D013141:Spiro Compounds; C475125:spirastrellolide A; D002244:Carbon