title: Cytogenetic findings in clear cell chondrosarcoma.
abstract: Clear cell chondrosarcoma is a rare cartilaginous tumor of low-grade malignancy that most often arises in the epiphysis of long bones in the third and fourth decades of life. Cytogenetic studies of clear cell chondrosarcoma are few. In this study, the cytogenetic findings of 4 cases of clear cell chondrosarcoma are presented. Clonal chromosomal abnormalities were detected in 3 cases. A tumor specific anomaly was not identified, however, extra copies of chromosome 20 and loss or rearrangements of 9p appear to be recurrent.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, N 68198-3135, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Nishio
authors.forename: John D
authors.initials: JD
authors.lastname: Reith
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.forename: Gary
authors.initials: G
authors.lastname: Maale
authors.forename: James R
authors.initials: JR
authors.lastname: Neff
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics*; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002890:Chromosomes, Human, Pair 20; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D018227:Sarcoma, Clear Cell / Q000235:genetics / Q000473:pathology