title: N-acetyl-transferase phenotype and risk for preeclampsia.
abstract: OBJECTIVE
  This study was undertaken to determine whether the N-acetyltransferase (NAT) phenotype contributes to the susceptibility for the development of preeclampsia.
  
  
  METHODS
  The NAT acetylator status was determined by measuring urinary caffeine metabolites in 134 nonpregnant women with a history of preeclampsia and in 109 control women with uncomplicated pregnancy. The chi(2) and logistic regression analyses were used for statistical evaluation of differences in acetylator status.
  
  
  RESULTS
  Significantly more fast acetylators were found among the women with a history of preeclampsia (46.3%) than among the controls (25.4%). Fast acetylators showed an odds ratio of 2.5 (95% CI 1.4-4.3) for preeclampsia. No differences in the acetylator status were found between women with a history of preeclampsia only and those with the HELLP syndrome as well.
  
  
  CONCLUSIONS
  The fast NAT acetylator status, which may result in altered NAT detoxification capacity, is associated with preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: Petra L M
authors.initials: PL
authors.lastname: Zusterzeel
authors.forename: René H M
authors.initials: RH
authors.lastname: te Morsche
authors.forename: Maarten T M
authors.initials: MT
authors.lastname: Raijmakers
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Roes
authors.forename: Wilbert H M
authors.initials: WH
authors.lastname: Peters
authors.forename: Régine P M
authors.initials: RP
authors.lastname: Steegers-Theunissen
authors.forename: Eric A P
authors.initials: EA
authors.lastname: Steegers
mesh_terms: D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002110:Caffeine / Q000378:metabolism / Q000652:urine; D005260:Female; D020022:Genetic Predisposition to Disease; D017359:HELLP Syndrome / Q000235:genetics; D006801:Humans; D010641:Phenotype; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D012907:Smoking / Q000235:genetics / Q000378:metabolism
chemical_list: D002110:Caffeine; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human