Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b.
Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.
Fukasawa
Yutaka
Y
Department of Microbiology, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Japan.
Kawamura
Ikuo
I
Uchiyama
Ryosuke
R
Yamamoto
Kazuhiro
K
Kaku
Taijin
T
Tominaga
Takanari
T
Nomura
Takamasa
T
Ichiyama
Satoshi
S
Ezaki
Takayuki
T
Mitsuyama
Masao
M
D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology*; D014376:Tuberculosis / Q000276:immunology
D016207:Cytokines; D013307:Streptomycin