title: Liquid bandage (2-octyl cyanoacrylate) as a temporary wound barrier in clear corneal cataract surgery.
abstract: OBJECTIVE
  To determine the feasibility and side effect profile of 2-octyl cyanoacrylate with parabens (Liquid Bandage) as an adjunct wound sealant and barrier against the inflow of ocular surface fluid after clear corneal cataract surgery.
  
  
  METHODS
  Prospective interventional case series.
  
  
  METHODS
  Fifty-one eyes of 51 patients undergoing clear corneal cataract surgery.
  
  
  METHODS
  Fifty-one eyes of 51 patients who underwent cataract surgery by one surgeon (RSK) were enrolled. A 2.75-mm clear corneal, triplanar, temporal incision was used in each case, followed by routine phacoemulsification. At the conclusion of each case, the wound was dried with a cellulose sponge. A modified microsponge with 1 to 2 drops of 2-octyl cyanoacrylate with parabens was then applied in a smooth layer to the wound. All wounds were rechecked for leakage with a cellulose sponge applied at the wound lip. The following criteria were evaluated on the first 2 postoperative visits: (1) visual acuity; (2) patient complaints; (3) wound integrity; (4) presence of tissue adhesive; and (5) any adverse events, including abnormal increase in local tissue reaction to the adhesive.
  
  
  METHODS
  Side effect profile and clinical course of 2-octyl cyanoacrylate with parabens applied to clear corneal wounds.
  
  
  RESULTS
  All 51 eyes demonstrated intraoperative watertight wound closure after the application of 2-octyl cyanoacrylate with parabens. Forty-five eyes (88%) had tissue adhesive still completely covering the wound on postoperative day 1. Two eyes (4%) had tissue adhesive over portions of their wound, and 4 eyes (8%) had no adhesive noted on their wound. All wounds were watertight on all postoperative visits. Thirty-one of 51 patients (61%) complained of mild transient foreign body sensation on postoperative day 1. Twenty-six patients (51%) had trace diffuse bulbar conjunctival hyperemia. Five patients had trace focal conjunctival hyperemia adjacent to the wound. Nine patients (18%) had remnants of the adhesive remaining on the second postoperative visit.
  
  
  CONCLUSIONS
  Our study demonstrates the ease of use and applicability and low side effect profile of 2-octyl cyanoacrylate with parabens as a temporary wound barrier in clear corneal cataract surgery.
authors.affiliation: Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003, USA.
authors.forename: Seth W
authors.initials: SW
authors.lastname: Meskin
authors.forename: David C
authors.initials: DC
authors.lastname: Ritterband
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Shapiro
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Kusmierczyk
authors.forename: Susan S
authors.initials: SS
authors.lastname: Schneider
authors.forename: John A
authors.initials: JA
authors.lastname: Seedor
authors.forename: Richard S
authors.initials: RS
authors.lastname: Koplin
mesh_terms: D003315:Cornea / Q000187:drug effects* / Q000601:surgery; D003487:Cyanoacrylates / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000517:prevention & control; D006801:Humans; D010226:Parabens / Q000627:therapeutic use; D018918:Phacoemulsification / Q000379:methods*; D010865:Pilot Projects; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003487:Cyanoacrylates; D010226:Parabens; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate