DNA translocation in inorganic nanotubes.
Inorganic nanotubes were successfully integrated with microfluidic systems to create nanofluidic devices for single DNA molecule sensing. Inorganic nanotubes are unique in their high aspect ratio and exhibit translocation characteristics in which the DNA is fully stretched. Transient changes of ionic current indicate DNA translocation events. A transition from current decrease to current enhancement during translocation was observed on changing the buffer concentration, suggesting interplay between electrostatic charge and geometric blockage effects. These inorganic nanotube nanofluidic devices represent a new platform for the study of single biomolecule translocation with the potential for integration into nanofluidic circuits.
Fan
Rong
R
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Karnik
Rohit
R
Yue
Min
M
Li
Deyu
D
Majumdar
Arun
A
Yang
Peidong
P
D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004563:Electrochemistry; D044085:Microfluidics; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D043942:Nanotubes; D017422:Sequence Analysis, DNA / Q000379:methods
D004247:DNA