title: Emerging concepts in the treatment of intracranial aneurysms: stents, coated coils, and liquid embolic agents.
abstract: Endovascular techniques for the treatment of intracranial aneurysms are rapidly evolving. Modifications of more traditional coils have been introduced. Such modifications include newer coils coated with various polymers to increase both coil thrombogenicity and degree of aneurysm packing. In addition, newer coil designs aimed at improving the conformability of the coil to the aneurysm have been used with promising preliminary results. The availability of a newer generation of stents specifically designed for intracranial navigation allows for more effective treatment of aneurysms with wide necks, which usually have been considered unsuitable for optimal endovascular treatment. Endovascular alternatives to coil embolization, such as liquid embolic materials, also have been explored for the treatment of intracranial aneurysms, with varying results. We summarize the rationale for use of these newer devices and early clinical experiences. Areas of current research and future directions of endovascular aneurysm treatment also are discussed.
authors.affiliation: Department of Neurosurgery, Illinois Neurological Institute, University of Illinois College of Medicine, Peoria, IL 61637, USA. lanzino@uic.edu
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lanzino
authors.forename: Yassine
authors.initials: Y
authors.lastname: Kanaan
authors.forename: Paolo
authors.initials: P
authors.lastname: Perrini
authors.forename: Hayan
authors.initials: H
authors.lastname: Dayoub
authors.forename: Kenneth
authors.initials: K
authors.lastname: Fraser
mesh_terms: D004621:Embolization, Therapeutic / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D005240:Feasibility Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D010984:Platinum / Q000627:therapeutic use; D011108:Polymers / Q000627:therapeutic use; D019736:Prostheses and Implants; D015607:Stents / Q000600:supply & distribution*; D016896:Treatment Outcome
chemical_list: D011108:Polymers; D010984:Platinum