Histological examination of the liver after experimental administration of MK-801 and dexamethasone.
The aim of the research was histological assessment of the influence of MK-801 (NMDA receptor antagonist) and dexamethasone on the liver. The experiment was carried out on adult Albino-Swiss mouse males. MK-801 was administered in the dose of 0.3 mg/kg/24 h for 8 days, dexamethasone--in the toxic dose of 120 mg/kg/24 h. Liver slices stained with hematoxylin and eosin were examined with light microscope. The performed experiments revealed that MK-801 can cause morphological changes of the liver in the shape of increased transparence of hepatocyte cytoplasm and narrowing of the liver sinusoids. MK-801 intensifies liver damage induced by toxic doses of dexamethasone leading to focal necrosis of hepatocytes.
Sekita-Krzak
Joanna
J
Department of Histology and Embryology with the Laboratory for Experimental Cytology, Skubiszewski Medical University of Lublin.
Czerny
Krystyna
K
Zebrowska-Lupina
Iwona
I
Danilczuk
Zofia
Z
Stepniewska
Maria
M
D000818:Animals; D003907:Dexamethasone / Q000633:toxicity*; D016291:Dizocilpine Maleate / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice
D016291:Dizocilpine Maleate; D003907:Dexamethasone