[Acute leukemias epidemiology in children. Part 1].
This paper is a revision from recent studies related to acute leukemia (AL) epidemiology in children. Cancer is the second cause of death in the pediatric population in Mexico between 1 to 15 years old. The AL are the types of cancer with more frequency in children below 15 years old and the cost of taking care of a child with cancer represents to the health institutions around 620 thousand dollars per year per case. In different places of the world the frequency of the AL has been increased and in Mexico City this is similar. Data from Instituto Mexicano del Seguro Social, in Mexico City, reports one of the highest worldwide. The environmental risk factors most consistent are the exposure in utero to X-ray, occupational exposure and pesticides. Other risk factors studied, as the exposure to electromagnetic fields, smoking and alcohol consumption in the parents, diet, and others, have had controversial results. These controversies can be explained by methodological mistakes in the studies and also because these studies did not assess the interaction between the susceptibility to AL and the environmental factors, a situation that could lead to the better understanding of the causal mechanisms of the disease. However it is recommended to have an attitude of prudent caution to accept that these factors are a cause of AL, and to have an energetic position in order to decrease the exposure to them and produce more adequate preventive strategies.
Mejía Aranguré
Juan Manuel
JM
Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. jmejiaa@cis.gob.mx
Ortega Alvarez
Manuel Carlos
MC
Fajardo Gutiérrez
Arturo
A
D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors