The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. III. Structure determination.
A novel gluconeogenesis inhibitor, FR225654 was isolated from the culture broth of Phoma sp. No. 00144. Spectroscopic analysis concluded that FR225654 has a highly oxygenated trans-decalin ring and beta-keto-enol in its main part, and has a characteristic side chain possessing a conjugated carboxylic acid and tri-substituted olefin.
Ohtsu
Yoshihiro
Y
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd.
Yoshimura
Seiji
S
Kinoshita
Takayoshi
T
Takase
Shigehiro
S
Nakajima
Hidenori
H
D005943:Gluconeogenesis / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C504133:FR225654; D007004:Hypoglycemic Agents; D009281:Naphthalenes