[Correlation between the prognosis and the expression of survivin in surgical margins of laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the relationship between the local recurrence and the five years survival rate and the expression of Survivin in surgical margins of laryngeal squamous cell carcinoma.


METHODS
Immunohistochemical technique (S-P) and image analysis were used to detect the expression of Survivin in the pathological negative margin specimen and primary site of cancer of 54 patients.


RESULTS
(1) Expression of Survivin was detected in 66. 7% (36/54) in laryngeal carcinoma, 40.7% (22/54) in surgical margins and negative in normal mucous membrane of palatoglossal pillar. A significant difference was observed for positive index(PI) in three groups (P < 0.01). (2) PI of Survival in surgical margins of patients with the local recurrence was higher than those with no local recurrence (P < 0.01). (3) The 5-year survival rate of patients with Survivin positive margin was lower than those with negative margin (29.3% vs 58.5%, P < 0.01).


CONCLUSIONS
The expression of Survivin in surgical margins may predict the possibility of local recurrence and poor prognosis in a certain extent for patients with laryngeal carcinoma, which may guide the treatment after surgery.
Zhao
Houyu
H
Department of Otolaryngology, The Affiliated Hospital of Guiyang Medical College, Guiyang, 550004, China.
Chen
Qianmei
Q
Ren
Jie
J
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011379:Prognosis; D015996:Survival Rate; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin