Human chorionic gonadotropin in cervical fluid as a predictor of miscarriage.
OBJECTIVE
To determine whether the concentration of hCG in cervical fluid can predict miscarriage during early pregnancy.


METHODS
Prospective clinical study.


METHODS
University hospital.


METHODS
Ninety-nine women with singleton pregnancies, 17 of whom suffered a miscarriage.


METHODS
None.


METHODS
Miscarriage and the cervical fluid/serum hCG concentration ratio.


RESULTS
With a cutoff value of 1.0, the sensitivity, specificity, and positive and negative predictive values of the cervical fluid/serum hCG concentration ratio for predicting miscarriage were 88.2%, 94.9%, 83.3%, and 96.6%, respectively.


CONCLUSIONS
The cervical fluid/serum hCG concentration ratio might be a useful predictor of miscarriage during early pregnancy.
Takata
Kayoko
K
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan. takata@hama-med.ac.jp
Suganuma
Nobuhiko
N
Wada
Hisae
H
Takeuchi
Kinya
K
Kitamura
Kimiya
K
Kanayama
Naohiro
N
D000022:Abortion, Spontaneous / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000032:analysis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D006063:Chorionic Gonadotropin