title: Failure of selective termination and dexamethasone rescue therapy to arrest HELLP syndrome in a midtrimester triplet gestation with one triploid fetus.
abstract: We present a case of a patient with a triplet pregnancy at 22 weeks with one triploid fetus (69XXX) who developed severe preeclampsia that did not reverse with dexamethasone rescue therapy and selective termination. With multiple gestations on the rise and the early diagnosis of abnormal pregnancies being accomplished through ultrasound, serum markers, and invasive procedures, the question remains if there is a point in gestation before which selective termination of an abnormal fetus would allow the pregnancy to continue without preeclampsia developing or progressing. Appropriate counseling as to the maternal risk in cases of trisomy 13 or triploidy is essential as early in pregnancy as possible.
authors.affiliation: Department of Obstetrics and Gynecology, North Shore University Hospital, Manhasset, New York 11030, USA.
authors.forename: Nadav
authors.initials: N
authors.lastname: Schwartz
authors.forename: Burton
authors.initials: B
authors.lastname: Rochelson
authors.forename: Jessica
authors.initials: J
authors.lastname: Jacob
mesh_terms: D000328:Adult; D003907:Dexamethasone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D014310:Triplets; D014314:Trisomy
chemical_list: D003907:Dexamethasone