title: Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis.
abstract: We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.
authors.affiliation: Laboratory of Molecular Medicine and Biotechnology, IRCCS S. Maria Nascente, Don C. Gnocchi Foundation, 66, Milan, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Saresella
authors.forename: Ivana
authors.initials: I
authors.lastname: Marventano
authors.forename: Livianna
authors.initials: L
authors.lastname: Speciale
authors.forename: Stefania
authors.initials: S
authors.lastname: Ruzzante
authors.forename: Daria
authors.initials: D
authors.lastname: Trabattoni
authors.forename: Silvia
authors.initials: S
authors.lastname: Della Bella
authors.forename: Massimo
authors.initials: M
authors.lastname: Filippi
authors.forename: Francesca
authors.initials: F
authors.lastname: Fasano
authors.forename: Rosella
authors.initials: R
authors.lastname: Cavarretta
authors.forename: Domenico
authors.initials: D
authors.lastname: Caputo
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ferrante
mesh_terms: D000208:Acute Disease; D000328:Adult; D017209:Apoptosis; D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004676:Myelin Basic Protein / Q000378:metabolism* / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D019014:fas Receptor / Q000378:metabolism
chemical_list: D015415:Biomarkers; D004676:Myelin Basic Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; D013755:Tetradecanoylphorbol Acetate