Hypoxia-inducible factor as a physiological regulator.
Hypoxia-inducible factor (HIF) is a transcription complex which responds to changes in oxygen, providing cells with a master regulator that coordinates changes in gene transcription. HIF operates in all mammalian cell types and is ancient in evolutionary terms, being conserved in C. elegans and D. melanogaster. This review summarizes recent insights into the molecular events that link reduced oxygenation to HIF activation and emerging insights into the extensive role of HIF in a broad range of physiological processes.
Maxwell
Patrick H
PH
Hammersmith Campus, Imperial College, London W12 0NN, UK. p.maxwell@imperial.ac.uk
D000818:Animals; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases; D017874:Immediate-Early Proteins / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism
D051793:Hypoxia-Inducible Factor 1; D017874:Immediate-Early Proteins; C490190:EGLN1 protein, human; D011393:Procollagen-Proline Dioxygenase; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases; D010100:Oxygen