The influence of experimental administration of ethanol and cephalexin on stomach mucous barrier of rat.
The Wistar rat males weighing approximately 200 g were administered 20% ethanol ad libitum during 10 days, cephalexin in the dose of 42 mg/24 h, and simultaneously ethanol and cephalexin in the above-mentioned doses. After 10 days the animals were decapitated and stomach specimens were taken from the major curvature region for examinations. They were fixed in 10% formalin, dehydrated and immersed in paraffin. For the purpose of estimation changes in activity of gastric gland mucous cells Mc Manus's PAS reaction was performed on 7 micro-thick sections. It was found that ethanol causes functional decrease in the activity of mucous cells. However, cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. A simultaneous administration of ethanol and cephalexin causes atrophic changes in gastric glands, and thereby strong reduction of mucous cells activity.
Zarebska
Alicja
A
Department of Histology and Embryology, Lab of Experimental Cytology, Skubiszewski Medical University of Lublin.
Hernik
Daria
D
Matusiewicz
Janusz
J
Czerny
Krystyna
K
D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002506:Cephalexin / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012636:Secretory Rate / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000431:Ethanol; D002506:Cephalexin