title: Joint effect of selection, linkage and partial inbreeding on additive genetic variance in an infinite population.
abstract: Under the inifinitesimal model of gene effects, selection reduces the additive genetic variance by inducing negative linkage disequilibrium among selected genes. If the selected genes are linked, the decay of linkage disequilibrium is delayed, and the reduction of additive genetic variance is enhanced. Inbreeding in an infinite population also alters the additive genetic variance through the generation of positive association among genes within a locus. In the present study, the joint effect of selection, linkage and partial inbreeding (partial selfing or partial full-sib mating) on the additive genetic variance was modeled. The recurrence relations of the additive genetic variance between successive generations and the prediction equation of the asymptotic additive genetic variance were derived. Numerical computation showed that although partially inbred populations initially maintain larger genetic variances, the accumulated effect of selection overrides the effect of inbreeding. Stochastic simulation was carried out to check the precision of prediction, showing that the obtained equations give a satisfactory prediction during initial generations. However, the predicted values always overestimate the simulated values, especially in later generations. Based on these results, possible extensions and perspectives of the assumed model were discussed.
authors.affiliation: Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kyoto, Japan. nomurat@cc.kyoto-su.ac.jp
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nomura
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003198:Computer Simulation; D008040:Genetic Linkage / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D007178:Inbreeding; D008957:Models, Genetic; D015233:Models, Statistical; D012641:Selection, Genetic