title: The use of stereotactic radiosurgery in the management of meningiomas.
abstract: This is a systematic review of a consecutive series of 309 meningiomas treated with gamma knife stereotactic radiosurgery between 1994 and 2000. There was an extreme selection bias towards lesions unfavourable for surgery, determined by the patients referred for treatment: 70% of tumours involved the skull base, 47% specifically the cavernous sinus: 15% of patients had multiple meningiomatosis or type 2 neurofibromatosis. Tumour histology was the main determinant of growth control (p < 0.001), the 5-year actuarial control rates being 87% for typical meningiomas, 49% for atypical tumours and 0% for malignant lesions. Complications from radiosurgery were rare, occurring in 3% of tumours, and were most frequently trigeminal and eye movement disturbances treating cavernous sinus meningiomas. Given the problems inherent in managing these tumours, radiosurgery is a valuable strategy and adjuvant treatment for these meningiomas.
authors.affiliation: National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Irfan
authors.initials: I
authors.lastname: Malik
authors.forename: J G
authors.initials: JG
authors.lastname: Rowe
authors.forename: L
authors.initials: L
authors.lastname: Walton
authors.forename: M W R
authors.initials: MW
authors.lastname: Radatz
authors.forename: A A
authors.initials: AA
authors.lastname: Kemeny
mesh_terms: D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000601:surgery*; D008579:Meningioma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery; D016518:Neurofibromatosis 2 / Q000601:surgery; D016634:Radiosurgery / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D012086:Reoperation; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome