Further analysis of the risk of adverse birth outcome after maternal use of fluoroquinolones.
In a database cohort study, the risk of adverse birth outcome in Danish women who redeemed a fluoroquinolone prescription during pregnancy was examined. Among 87 women who redeemed a fluoroquinolone prescription at any time during the pregnancy, the prevalence ratio of preterm birth was 1.4 (95% confidence interval (CI), 0.6-3.2), one woman had a stillbirth, and no children died during the perinatal period. Among 130 women who redeemed a prescription during the first trimester or 30 days before conception, the prevalence ratio of congenital malformation was 0.7 (95% CI, 0.3-2.0) and the prevalence ratio of bone malformations was 2.2 (95% CI, 0.7-6.7). Our study raises the concern that prenatal fluoroquinolone exposure may be associated with an increased risk of bone malformations.
Wogelius
Pia
P
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark. aas.uxpiwo@nja.dk
Nørgaard
Mette
M
Gislum
Mette
M
Pedersen
Lars
L
Schønheyder
Henrik C
HC
Sørensen
Henrik Toft
HT
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000328:Adult; D001842:Bone and Bones / Q000002:abnormalities*; D015331:Cohort Studies; D016208:Databases, Factual; D003718:Denmark / Q000453:epidemiology; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D011153:Population; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011264:Pregnancy Trimesters; D047928:Premature Birth / Q000453:epidemiology; D015995:Prevalence
D024841:Fluoroquinolones