NF-kappaB: linking inflammation and immunity to cancer development and progression.
There has been much effort recently to probe the long-recognized relationship between the pathological processes of infection, inflammation and cancer. For example, epidemiological studies have shown that approximately 15% of human deaths from cancer are associated with chronic viral or bacterial infections. This Review focuses on the molecular mechanisms that connect infection, inflammation and cancer, and it puts forward the hypothesis that activation of nuclear factor-kappaB (NF-kappaB) by the classical, IKK-beta (inhibitor-of-NF-kappaB kinase-beta)-dependent pathway is a crucial mediator of inflammation-induced tumour growth and progression, as well as an important modulator of tumour surveillance and rejection.
Karin
Michael
M
Laboratory of Gene Regulation and Signal Transduction, University of California at San Diego School of Medicine, Department of Pharmacology, 9500 Gilman Drive, La Jolla, California 92093-0723, USA. karinoffice@ucsd.edu
Greten
Florian R
FR
D000818:Animals; D006801:Humans; D007239:Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology; D018448:Models, Immunological; D016328:NF-kappa B / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000382:microbiology; D015398:Signal Transduction / Q000276:immunology
D016328:NF-kappa B