Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells.
CD14 is a pattern recognition receptor; its important role in innate immunity is reviewed here. Since its discovery and subsequent classification at the first leucocyte typing workshop in 1982, CD14 has been thought of as a leucocyte differentiation antigen. However, it has become clear that CD14 is also expressed by many non-myeloid cells, and the evidence for this is presented. The possible role of the presence of low copy number CD14 on non-myeloid cells is discussed. It is time to acknowledge CD14 as an ubiquitous molecule and abandon the position that it is expressed by myeloid cells alone.
Jersmann
Hubertus P A
HP
Lung Research Laboratory, Hanson Institute, University of Adelaide, Adelaide, South Australia, Australia. hubertus.jersmann@adelaide.edu.au
D000818:Animals; D019070:Cell Lineage / Q000276:immunology; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis* / Q000235:genetics*; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism*
D018950:Lipopolysaccharide Receptors