Effects of short-term supplementation with folic acid on different oxidative stress parameters in patients with hypertension.
Oxidative stress seems to play an important role in the pathophysiology of essential hypertension. Due to its antioxidant features, we studied the protective action of folic acid in hypertensive patients, their food supplemented for 2 weeks with this vitamin. Several oxidative stress parameters were measured in the serum of these patients. The results show that folic acid supplementation improves levels of oxidative stress markers in individuals with hypertension, overall in those patients whose initial parameter values were highest.
Stiefel
Pablo
P
Unidad de Hipertension y Lipidos, Departamento de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Seville, Spain.
Argüelles
Sandro
S
García
Sonia
S
Jiménez
Luis
L
Aparicio
Reyes
R
Carneado
Joaquín
J
Machado
Alberto
A
Ayala
Antonio
A
D000328:Adult; D000368:Aged; D019587:Dietary Supplements; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000178:diet therapy / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014803:Vitamin B Complex / Q000008:administration & dosage* / Q000097:blood
D017392:Thiobarbituric Acid Reactive Substances; D006710:Homocysteine; D014803:Vitamin B Complex; D005492:Folic Acid