title: [Generalized tetanus with intractable autonomic cardiovascular instability in an aged woman].
abstract: Tetanus is characterized by tetanic convulsions related to the actions of tetanospasmin produced by Clostridium tetani. Another important characteristic of tetanus is the instability of the cardiovascular system related to sympathetic hyperactivity in the autonomic nervous system, and it may be an important prognostic factor. We report a patient with tetanus in whose unstable circulatory kinetics made circulation management difficult. A 77-year-old woman who injured in a fall, 11 days after trismus appeared and 3 day after convulsion appeared. It was not severe case in the acuity classification. However, repeated generalized convulsions and autonomic imbalance involving the cardiovascular system were observed clinically, suggesting a severe case. Because of the unstable circulatory kinetics, the patient was carefully managed was performed in the intensive care unit (ICU), and she improved. ICU management may be essential for treating severe tetanus with cardiovascular complications. Acquired immunity is not achieved after the onset of tetanus, and since elderly people, in particular, as in our own caset, are easily injured when they fall, we recommend vaccination.
authors.affiliation: Department of Clinical Infectious Diseases, Toyama Medical and Pharmaceutial University.
authors.forename: Munetoshi
authors.initials: M
authors.lastname: Narukawa
authors.forename: Muneharu
authors.initials: M
authors.lastname: Maruyama
authors.forename: Akira
authors.initials: A
authors.lastname: Yasuoka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Funada
authors.forename: Masashi
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002319:Cardiovascular System / Q000503:physiopathology*; D005260:Female; D006801:Humans; D013742:Tetanus / Q000503:physiopathology*