IL-6 and FAS (CD95) serum level in patients suffering from psoriasis and in relation to the lymphocyte subpopulations.
In the presented study the subpopulations of blood lymphocytes as well as serum concentrations of IL-6 and FAS in 20 patients with psoriasis triggered by infection and 17 healthy controls were analyzed. The flow cytometry technique and ELISA method were used. We detected statistically significant higher serum level of interleukin-6 (IL-6) in patients with active disease and tendency to the lowering of FAS level, although not statistically significant. Analysis of the correlation between the parameters showed that it was close to statistical significance for IL-6 and CD 95, p = 0.06 and R = 0.41. IL-6 level correlated positively with percentage of CD45RO+ cells (p = 0.05, R = 0.28) and negatively with percentage of CD3+ cells (p = 0.02, R = -0.34), CD4+ cells (p = 0.02, R = -0.34), CD 45RA+ cells (p = 0.04, R = -0.68).
Pietrzak
Aldona
A
Chair and Department of Dermatology, Skubiszewski Medical University of Lublin.
Podhorecka
Monika
M
Chodorowska
Grazyna
G
Roliński
Jacek
J
Kowal
Małgorzata
M
Junak-Bojarska
Agnieszka
A
Urban
Janusz
J
D000328:Adult; D017209:Apoptosis / Q000276:immunology; D049109:Cell Proliferation; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D015603:Keratinocytes / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000150:complications / Q000276:immunology; D013223:Statistics as Topic; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019014:fas Receptor / Q000097:blood*
D015850:Interleukin-6; D019014:fas Receptor