[Metabolism of drugs. II. The factors influencing metabolic reactions].
Among the factors influencing metabolic reactions leading to inactivation of the drugs the differences resulting from properties of the specific metabolic pathways, present in various species, alterations in hepatic enzymes activity, factors influencing the degree of xenobiotics binding to proteins (albumin, lipoproteins, and alphalacid glycoprotein) should be taken into consideration. Hepatic blood flow efficiency, age, sex and diseases, hormonal regulation (mainly glucocorticosteroids and thyroid) glanol are examples of factors exerting an influence on the metabolic reactions of the organism. Important role may also be assigned to lipid-free or low protein diet.
Dyderski
Stanisław
S
Katedra i Zakład Farmacji Klinicznej i Biofarmacji Akademii Medycznej im. Karola Marcinkowskiego, Poznaniu.
Grzymisławski
Marian
M
D000367:Age Factors; D000418:Albumins / Q000378:metabolism; D002352:Carrier Proteins; D004032:Diet; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008102:Liver Circulation / Q000187:drug effects*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012737:Sex Factors; D013963:Thyroid Hormones / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism*
D000418:Albumins; D002352:Carrier Proteins; D006023:Glycoproteins; D008074:Lipoproteins; D004364:Pharmaceutical Preparations; D013963:Thyroid Hormones; D015262:Xenobiotics