Lethal infection of C3H/HeJ and C3H/SCID mice with an isolate of Leptospira interrogans serovar copenhageni.
Leptospira interrogans serovar Copenhageni strain RJ16441, a blood isolate from humans with the severe pulmonary form of leptospirosis, has previously been shown to cause fatal pulmonary hemorrhage in guinea pigs and asymptomatic chronic renal tubular colonization with urinary shedding in rats. In this study, RJ16441 caused lethal infection of both C3H/HeJ and C3H/SCID mice, but no hemorrhagic phenomena were observed.
Nally
Jarlath E
JE
Department of Medicine, Division of Infectious Diseases, University of California--Los Angeles, 90095, USA. jnally@mednet.ucla.edu
Fishbein
Michael C
MC
Blanco
David R
DR
Lovett
Michael A
MA
D000818:Animals; D016470:Bacteremia / Q000382:microbiology* / Q000473:pathology; D007668:Kidney / Q000382:microbiology* / Q000473:pathology; D007921:Leptospira interrogans / Q000302:isolation & purification / Q000472:pathogenicity*; D007922:Leptospirosis / Q000382:microbiology / Q000473:pathology*; D008099:Liver / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D016513:Mice, SCID