Correlates of excessive daytime sleepiness in Parkinson's disease.
Measures of excessive daytime sleepiness, neuropsychologic function, and mood were assessed in twenty-two persons with mid-stage Parkinson's disease (PD) and sixteen age-matched healthy controls. Levodopa dose equivalents (LDE) were computed for the patients. While Epworth sleepiness score (ESS), Mini Mental State Exam, logical memory, Stroop, and the mood scales, reliably distinguished patients from controls, only the mood scales (especially anxiety) were reliably associated with ESS. LDE was not significantly associated with ESS. Excessive daytime sleepiness in patients with mid-stage PD may be more strongly related to anxiety than to other neuropsychologic dysfunction or dopaminergic dosing levels.
Wegelin
Jacob
J
Division of Biostatistics, Department of Public Health Sciences, University of California, Davis School of Medicine,2921 Stocken Blvd, Sacramento CA 95817, USA. jawegelin@ucdavis.edu
McNamara
Patrick
P
Durso
Raymon
R
Brown
Ariel
A
McLaren
Deirdre
D
D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D012894:Sleep Stages
D000978:Antiparkinson Agents