title: The susceptibility of certain microbial strains to fused 1,2,4-triazole derivatives.
abstract: 1,2,4-Triazole is the structural element of many drugs that have different pharmacological spectrum of activity. Besides, from the literature data it follows that 1,2,4-triazoles and its fused systems show antibacterial, antifungal and anti-inflammatory activities. The obtained compounds were tested for their potential antimicrobial activity. Microbiological tests conducted on 106 strains of bacteria, 6 strains of yeast-like fungi and 3 strains of moulds have shown that all the tested compounds in the examined concentrations (100 microg ml(-1) and 200 microg ml(-1)) had no influence on the growth of the tested bacteria and moulds. It has been found that among variously substituted derivatives of imidazotriazole system compound V significantly inhibited the growth of 6 strains of Candida albicans in the examined concentrations. Its chemical structure was similar to novel antifungal agents described in the literature.
authors.affiliation: Department of Synthesis and Technology of Drugs, Skubiszewski Medical University of Lublin.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sztanke
authors.forename: Anna
authors.initials: A
authors.lastname: Sidor-Wójtowicz
authors.forename: Janina
authors.initials: J
authors.lastname: Truchlińska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Pasternak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sztanke
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D014230:Triazoles