title: Improving organochlorine biomarker models for cancer research.
abstract: Multivariate methods were used to predict levels of dichlorodiphenyldichloroethene (DDE) and polychlorinated biphenyl (PCB) concentrations in plasma from characteristics that included age, diet, race, reproductive history, socioeconomic status, and reported body mass index (BMI) at several decades of life before blood collection. Measurements were available for organochlorine compound (organochlorines), cholesterol, and triglycerides in plasma from 1,008 women participants in a population-based case-control study of breast cancer undertaken in 1996 to 1997 on Long Island, NY. Organochlorine compound levels were associated with age, race, lactation history, body size characteristics, and plasma lipids. PCB predictors also included fish consumption. DDE was correlated with current BMI, BMI at every decade of age from ages 20 to 60 years, and BMI-gain (from ages 20 or 30 years to 1997). In contrast, PCBs were correlated inversely with both BMI (fifth to seventh decades of age) and BMI-gain. After adjusting for covariates, DDE and PCB were both positively associated with BMI and inversely with BMI-gain; they were lowest with low BMI, high BMI-gain, and longer lactation. This pattern is consistent with a pharmacokinetic model that predicts higher body burdens during windows of highest uptake, faster elimination of organochlorine compounds in leaner women, and lowered levels accompanying BMI-gain. As a result, lifetime intake for specific organochlorine compound may lead to different plasma levels dependent on changes in body size, absolute intensity of intake, and whether exposure is ongoing (i.e., PCB) or long discontinued (i.e., DDE).
authors.affiliation: Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. mary.wolff@mssm.edu
authors.forename: Mary S
authors.initials: MS
authors.lastname: Wolff
authors.forename: Julie A
authors.initials: JA
authors.lastname: Britton
authors.forename: Susan L
authors.initials: SL
authors.lastname: Teitelbaum
authors.forename: Sybil
authors.initials: S
authors.lastname: Eng
authors.forename: Elena
authors.initials: E
authors.lastname: Deych
authors.forename: Karen
authors.initials: K
authors.lastname: Ireland
authors.forename: Zhisong
authors.initials: Z
authors.lastname: Liu
authors.forename: Alfred I
authors.initials: AI
authors.lastname: Neugut
authors.forename: Regina M
authors.initials: RM
authors.lastname: Santella
authors.forename: Marilie D
authors.initials: MD
authors.lastname: Gammon
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology; D016022:Case-Control Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D004032:Diet; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D007306:Insecticides / Q000097:blood*; D007774:Lactation; D008875:Middle Aged; D008962:Models, Theoretical; D015999:Multivariate Analysis; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D011078:Polychlorinated Biphenyls / Q000097:blood; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls