A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents.
A one-step, mild procedure based on coaxial electrospinning was developed for incorporation and controlled release of two model proteins, BSA and lysozyme, from biodegradable core-shell nanofibers with PCL as shell and protein-containing PEG as core. The thickness of the core and shell could be adjusted by the feed rate of the inner dope, which in turn affected the release profiles of the incorporated proteins. It was revealed that the released lysozyme maintained its structure and bioactivity. The current method may find wide applications for controlled release of proteins and tissue engineering.
Jiang
Hongliang
H
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. hljiang@zju.edu.cn
Hu
Yingqian
Y
Li
Yan
Y
Zhao
Pengcheng
P
Zhu
Kangjie
K
Chen
Weiliam
W
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004339:Drug Compounding; D004591:Electrophoresis, Polyacrylamide Gel; D005079:Excipients; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D009113:Muramidase / Q000008:administration & dosage / Q000737:chemistry; D049329:Nanostructures; D010047:Ovalbumin / Q000737:chemistry; D011091:Polyesters; D011092:Polyethylene Glycols; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry
D003692:Delayed-Action Preparations; D005079:Excipients; D011091:Polyesters; D011506:Proteins; C016240:polycaprolactone; D011092:Polyethylene Glycols; D010047:Ovalbumin; D009113:Muramidase