title: Clinical, histologic, and histomorphometric evaluation of mineralized solvent-dehydrated bone allograf (Puros) in human maxillary sinus grafts.
abstract: Demineralized freeze-dried bone allografts (DFDBA) have been successfully used alone or in composite grafts for many decades. Little research has been done on the effect of retaining the mineral content of bone allografts. This study histologically and histomorphometrically evaluated a new mineralized bone allograft material placed in human atrophic maxillary sinuses. Seven partially edentulous patients requiring sinus grafts before implant placement were selected for this study Their age range was 56 to 81 years (mean 67.7 years). Test grafts consisted of a mineralized solvent-dehydrated cancellous bone allograft, and control grafts were a composite of DFDBA and deproteinized bovine bone xenograft (1:1). Bilateral cases (n = 3) received both test and control grafts on opposite sides, and unilateral cases received either a test (n = 3) or control (n = 1) graft only. At 10 months, core biopsies were taken from each graft site, and dental implants were placed into the augmented bone. All bone grafts resulted in new bone formation and all implants osseointegrated. Test grafts resorbed and were replaced by newly formed bone significantly faster and in greater quantities than were control grafts. No complications with grafts or implants were noted. Both test and control grafts achieved excellent results. The faster bone formation observed with the test graft may be due, in part, to its smaller particle size compared with the bovine portion of the control graft. Test grafts were either replaced by new bone or displayed new bone-to-particle surface contact in higher percentages than did control grafts. No differences in osseointegration or graft stability were noted 2 years after the study.
authors.affiliation: Implant Dentistry, Loma Linda University, Loma Linda, CA, USA. sammynoumbissi@comcast.net
authors.forename: Sammy S
authors.initials: SS
authors.lastname: Noumbissi
authors.forename: Jaime L
authors.initials: JL
authors.lastname: Lozada
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Boyne
authors.forename: Michael D
authors.initials: MD
authors.lastname: Rohrer
authors.forename: Donald
authors.initials: D
authors.lastname: Clem
authors.forename: Jay S
authors.initials: JS
authors.lastname: Kim
authors.forename: Hari
authors.initials: H
authors.lastname: Prasad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous; D003890:Desiccation; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D008903:Minerals; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D011446:Prospective Studies
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals