Psychostimulants, L-type calcium channels, kinases, and phosphatases.
There is growing evidence for the role of voltage-gated L-type Ca2+ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca2+ channels activate Ca2+ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca2+ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.
Rajadhyaksha
Anjali M
AM
Labortory of Molecular and Developmental Neuroscience, and Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. rajadhan@helix.mgh.harvard.edu
Kosofsky
Barry E
BE
D000818:Animals; D020746:Calcium Channels, L-Type / Q000737:chemistry / Q000502:physiology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D008959:Models, Neurological; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D019966:Substance-Related Disorders / Q000378:metabolism / Q000503:physiopathology; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000502:physiology
D020746:Calcium Channels, L-Type; D000697:Central Nervous System Stimulants; D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases