title: Advances in understanding bone cancer pain.
abstract: Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.
authors.affiliation: University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Goblirsch
authors.forename: P
authors.initials: P
authors.lastname: Zwolak
authors.forename: D R
authors.initials: DR
authors.lastname: Clohisy
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000150:complications* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D009448:Neurochemistry; D010146:Pain / Q000150:complications* / Q000503:physiopathology*; D059408:Pain Management