title: A new Coenzyme Q10 tablet-grade formulation (all-Q) is bioequivalent to Q-Gel and both have better bioavailability properties than Q-SorB.
abstract: Commercial Coenzyme Q10 (CoQ10, ubiquinone) formulations are often of poor intestinal absorption. We investigated the bioavailability of DSM Nutritional Products Ltd. (Kaiseraugst, Switzerland) CoQ10 10% TG/P (all-Q), a new tablet-grade formulation, with CoQ10 Q-Gel Softsules based on the Bio-Solv technology (Tishcon Corp., Salisbury, MD; marketed by Epic4Health, Smithtown, NY) and Q-SorB (Nature's Bounty, Bohemia, NY). Twelve healthy male subjects participated in a randomized, three-period crossover bioequivalence study. Plasma CoQ10 was determined from pre-dose until +36 hours. To compare bioavailability, corrected maximum concentration (Cmax) and area under the curve from 0 to +14 hours [AUC(0-14 h)] were assessed and tested for bioequivalence. The bioequivalence ranges of 0.8-1.25 hour x microg/mL for AUC(0-14 h) and 0.75-1.33 microg/mL for Cmax were applied. In summary, the kinetic profiles of all CoQ10 preparations revealed a one-peak plasma concentration-time course. Highest Cmax values were seen after Q-Gel application, whereas time to Cmax was nearly identical across all treatments. The AUC(0-14 h) values were highest for Q-Gel, narrowly followed by all-Q. The tests for bioequivalence showed a bioequivalence between Q-Gel and all-Q, and both preparations were found to have better bioavailability properties than Q-SorB. Although all-Q and Q-Gel have equivalent bioavailability properties, all-Q can be directly used in tablets, while this is not the case for Q-Gel or other similar forms.
authors.affiliation: R&D Human Nutrition & Health, DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Ullmann
authors.forename: J
authors.initials: J
authors.lastname: Metzner
authors.forename: C
authors.initials: C
authors.lastname: Schulz
authors.forename: J
authors.initials: J
authors.lastname: Perkins
authors.forename: B
authors.initials: B
authors.lastname: Leuenberger
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003067:Coenzymes; D018592:Cross-Over Studies; D005782:Gels; D006801:Humans; D007700:Kinetics; D008297:Male; D010316:Particle Size; D013607:Tablets; D013810:Therapeutic Equivalency; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D005782:Gels; D013607:Tablets; D014451:Ubiquinone; C024989:coenzyme Q10