title: A 6-month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque.
abstract: OBJECTIVE
  To evaluate the effects of a novel mouthrinse containing 0.07% high bioavailable cetylpyridinium chloride (Crest Pro-Health Rinse) on the development of gingivitis and plaque versus a placebo control over a period of 6 months.
  
  
  METHODS
  This was a randomized, 6-month, placebo-controlled, parallel groups, double blind, single center clinical trial. One hundred thirty-nine generally healthy adults with mild-to-moderate gingivitis were enrolled in the study. Subjects were given Modified Gingival Index (MGI), Gingival Bleeding Index (GBI) and Modified Quigley-Hein Plaque Index (MQH) examinations followed by a dental prophylaxis. Subjects were then randomly assigned to either the cetylpyridinium chloride (CPC) rinse or placebo rinse and instructed to begin rinsing twice a day with 20 ml of their assigned mouthrinse for 30 seconds after brushing their teeth. Subjects were assessed for MGI, GBI and MQH scores after 3 and 6 months of product use. Oral hard and soft tissue examinations were also performed at all visits.
  
  
  RESULTS
  124 subjects were evaluable at Month 3 and 119 at Month 6. After 6 months, subjects rinsing with the CPC rinse showed 15.4% less gingival inflammation, 33.3% less gingival bleeding, and 15.8% less plaque relative to the placebo group. All reductions were highly statistically significantly different (P< 0.01). Results were similar at 3 months. Both treatments were well-tolerated.
  
  
  CONCLUSIONS
  This study demonstrates that the Crest Pro-Health 0.07% CPC mouthrinse provided significant antiplaque and antigingivitis benefits when used twice daily for 6 months as an adjunct to toothbrushing.
authors.affiliation: Dental Products Testing Inc, West Palm Beach, Florida, USA.
authors.forename: Suru
authors.initials: S
authors.lastname: Mankodi
authors.forename: Karen
authors.initials: K
authors.lastname: Bauroth
authors.forename: Jon J
authors.initials: JJ
authors.lastname: Witt
authors.forename: Samer
authors.initials: S
authors.lastname: Bsoul
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.forename: Roger
authors.initials: R
authors.lastname: Gibb
authors.forename: John
authors.initials: J
authors.lastname: Dunavent
authors.forename: Amy
authors.initials: A
authors.lastname: Hamilton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000517:prevention & control; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D010919:Placebos
chemical_list: D000891:Anti-Infective Agents, Local; C505193:Crest Pro-Health mouthrinse; D009067:Mouthwashes; D010919:Placebos; D002594:Cetylpyridinium