The Bayesian Alcoholism Test had better diagnostic properties for confirming diagnosis of hazardous and harmful alcohol use.
OBJECTIVE
Conventional tests for alcoholism fail to confirm hazardous and harmful alcohol use (HHAU) accurately and objectively. We validated a Bayesian Alcoholism Test (BAT) for confirming the diagnosis of HHAU.


METHODS
BAT is based on studies on the prevalence of HHAU and other diseases causing similar abnormalities, and on conditional probabilities of these disorders and associated biochemical markers and clinical signs. BAT was compared to carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GGT) in treatment-seeking alcoholics, non-treatment-seeking heavy drinkers, and controls. Main outcome measures were test sensitivity and specificity, likelihood ratios, and receiver-operating characteristic (ROC) curves.


RESULTS
Comparing alcoholics and controls, sensitivity of BAT (94%) was significantly higher than CDT (63%) and GGT (73%). The area under the ROC curve for BAT (.989) was significantly higher than the area under the curve for CDT (.909) and area under the curve for GGT (.902). Using pooled data of all 182 subjects included in the study, the amount of drinking had a significant better correlation coefficient with BAT (.795) than with CDT (.657), and GGT (.604).


CONCLUSIONS
BAT has better diagnostic properties than CDT and GGT for confirming HHAU.
Korzec
Aleksander
A
Sint Lucas Andreas Hospital, Postbus 9423, 1006 AE Amsterdam, The Netherlands. a.korzec@slaz.nl
de Bruijn
Carla
C
van Lambalgen
Michiel
M
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000437:Alcoholism / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D004812:Epidemiologic Methods; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D014168:Transferrin / Q000031:analogs & derivatives / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D000431:Ethanol; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase