[The capsaicin receptor. "TRPing" transduction for painful stimuli].
The capsaicin receptor TRPV1, once discovered as a receptor for pungent spices, is a polymodal sensor molecule for painful chemical and thermal stimuli. However, TRPV1 plays an important role not only for the integration of acute painful stimuli but also in the genesis of inflammatory processes. The persistent functional sensitization of TRPV1 as well as an up-regulation of its expression may contribute to the development and maintenance of chronic pain states. Thus, TRPV1 is an excellent target for a rational pharmacological treatment of pain. Several additional physiological and pathophysiological functions of TRPV1 are assumed beyond nociception and pain. Activation of TRPV1 seems to contribute to the etiology and pathogenesis of inflammatory diseases concerning, e.g., the gastrointestinal tract, the bladder, and the respiratory system. Therefore, the therapeutic potential of a pharmacological manipulation of TRPV1 may not be restricted to a symptomatic therapy of pain.
Greffrath
W
W
Institut für Physiologie und Pathophysiologie, Johannes-Gutenberg-Universität Mainz. greffrat@uni-mainz.de
D002628:Chemoreceptor Cells / Q000503:physiopathology; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009619:Nociceptors / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D050916:TRPV Cation Channels / Q000502:physiology*; D013697:Thermosensing / Q000502:physiology; D015854:Up-Regulation / Q000502:physiology
D050916:TRPV Cation Channels; C494482:TRPV1 protein, human