title: Computed tomography and sonographic findings of hepatic metastases from gastrointestinal stromal tumors after chemotherapy.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the computed tomography (CT) and sonographic findings in patients with hepatic metastases from gastrointestinal stromal tumors (GISTs) after STI-571 treatment.
  
  
  METHODS
  Computed tomography and sonographic findings of 8 lesions in 6 patients with hepatic metastases from GISTs that were treated with STI-571 were retrospectively analyzed. The change in size, attenuation, and echogenicity of the hepatic metastases from GISTs after STI-571 treatment was evaluated.
  
  
  RESULTS
  After treatment with STI-571, the hepatic metastases were decreased in size and the attenuation of the hepatic metastases was homogeneously hypodense on CT. Sonography revealed the hepatic metastases to be centrally cystic with a thin wall (n = 4) or predominantly solid (n = 4) after STI-571 treatment. On color Doppler sonography, no blood flow was identified within the solid portion of the mass.
  
  
  CONCLUSIONS
  After treatment with STI-571, although the hepatic metastases from GISTs exhibit a cystic appearance on CT, they may appear as solid masses on sonography.
authors.affiliation: Department of Radiology, Gachon Medical School, Gil Medical Center, Incheon, South Korea. dmyang@ghil.com
authors.forename: Dal Mo
authors.initials: DM
authors.lastname: Yang
authors.forename: Hana
authors.initials: H
authors.lastname: Kim
authors.forename: Jee Hee
authors.initials: JH
authors.lastname: Kang
authors.forename: Chul Hi
authors.initials: CH
authors.lastname: Park
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Dong Bok
authors.initials: DB
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate