title: Delayed profound thrombocytopenia after abciximab administration for coronary stenting in acute coronary syndrome. Case reports and review of the literature.
abstract: Profound thrombocytopenia occurring 1 week after drug administration is a seldom described, self-limiting and mostly uneventful immune reaction to abciximab. Quick differential diagnosis is essential, since other forms of thrombocytopenia associated with concomitant antithrombotic therapies may be much more severe and require prompt treatment. Awareness of this reaction may avoid unnecessary and risky discontinuation of other antiplatelet therapies in the critical phase after coronary stenting.
authors.affiliation: A De Gasperis Cardiovascular Department,Niguarda Ca' Granda Hospital, Milan, Italy.
authors.forename: Gaia
authors.initials: G
authors.lastname: Trapolin
authors.forename: Stefano
authors.initials: S
authors.lastname: Savonitto
authors.forename: Piera Angelica
authors.initials: PA
authors.lastname: Merlini
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Caimi
authors.forename: Silvio
authors.initials: S
authors.lastname: Klugmann
mesh_terms: D000077284:Abciximab; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation / Q000379:methods; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D017023:Coronary Angiography; D005500:Follow-Up Studies; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D010956:Plasmapheresis / Q000379:methods; D010976:Platelet Count; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000628:therapy; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D007140:Immunoglobulin Fab Fragments; D000077284:Abciximab