A Diels-Alder macrocyclization enables an efficient asymmetric synthesis of the antibacterial natural product abyssomicin C.
Zapf
Christoph W
CW
Department of Chemistry, Princeton University, Princeton, NJ 08544-1009, USA.
Harrison
Bryce A
BA
Drahl
Carmen
C
Sorensen
Erik J
EJ
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D001685:Biological Factors; D019086:Bridged Bicyclo Compounds, Heterocyclic; C509797:abyssomicin C