title: Cord blood adiponectin in large-for-gestational age newborns.
abstract: OBJECTIVE
  The purpose of this study was to disclose the relationship between adiponectin and birth weight in a large group of newborns with normal and aberrant growth ("overweight").
  
  
  METHODS
  Eighty-one healthy, term newborns were divided into 2 groups: 20 in the large-for-gestational age (LGA; 4297 +/- 207 g), and 61 newborns in the appropriate-for-gestational age (AGA; 3384 +/- 368 g). Cord blood was analyzed for adiponectin, leptin, and insulin levels.
  
  
  RESULTS
  Mean adiponectin level was significantly lower in LGA newborns (29.4 +/- 13.8 vs 35.0 +/- 9.9 microg/mL, P < .04). Both leptin and insulin levels were higher in LGA than AGA newborns, and leptin levels positively correlated with birth weight in both groups. Insulin levels positively correlated with birth weight in AGA newborns.
  
  
  CONCLUSIONS
  The results of this study imply that adiponectin may have a role in fetal growth and support the notion of negative feedback exerted by adipose tissue on adiponectin levels, as previously shown in adults.
authors.affiliation: Department of Obstetrics and Gynecology, and Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Hannah
authors.initials: H
authors.lastname: Kanety
authors.forename: Clara
authors.initials: C
authors.lastname: Pariente
authors.forename: Rina
authors.initials: R
authors.lastname: Hemi
authors.forename: Eyal
authors.initials: E
authors.lastname: Schiff
authors.forename: Eyal
authors.initials: E
authors.lastname: Sivan
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000502:physiology*; D001724:Birth Weight / Q000502:physiology*; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood
chemical_list: D052242:Adiponectin; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin