title: Effect of toluene and nutritional status on serotonin, lipid peroxidation levels and NA+/K+-ATPase in adult rat brain.
abstract: The aim was to evaluate the effect of toluene and nutritional status on levels of serotonin (5-HT), 5-hydroxytryptophan (5-HTP), Na+/K+-ATPase, total ATPase and lipid peroxidation (TBARS) in rat brain. Study was conducted with malnourished (MN), well-nourished (WN) and normal Wistar rats. Three groups were formed for each nutritional status: control group I received 0.9% NaCl; toluene (1 g/kg) was administered to group II, and 1.5 g/kg to group III. Levels of 5-HT decreased (P < 0.05) in WN toluene groups, and 5-HTP decreased (P < 0.05) in the WN 1 g toluene and MN 1.5 g toluene groups. TBARS decreased (P < 0.05) in WN toluene groups. A trend to increase in Na+/K+-ATPase was found in WN and MN toluene groups, while total ATPase increased (P < 0.05) in the WN 1.5 g toluene group. The results suggest that high concentrations of toluene in single doses induce significant changes in the serotonergic system and alter membrane fluidity more perceptibly in the brain of adult animals with regular diet than in malnourished animals.
authors.affiliation: Laboratorio de Neuroquímica, Instituto Nacional de Pediatría , México.
authors.forename: David
authors.initials: D
authors.lastname: Calderón-Guzmán
authors.forename: Ivonne
authors.initials: I
authors.lastname: Espitia-Vázquez
authors.forename: Alejandra
authors.initials: A
authors.lastname: López-Domínguez
authors.forename: Ernestina
authors.initials: E
authors.lastname: Hernández-García
authors.forename: Bernardino
authors.initials: B
authors.lastname: Huerta-Gertrudis
authors.forename: Elvia
authors.initials: E
authors.lastname: Coballase-Urritia
authors.forename: Hugo
authors.initials: H
authors.lastname: Juárez-Olguín
authors.forename: Beatriz
authors.initials: B
authors.lastname: García-Fernández
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D009752:Nutritional Status; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014050:Toluene / Q000633:toxicity*
chemical_list: D012701:Serotonin; D014050:Toluene; D000254:Sodium-Potassium-Exchanging ATPase