title: A proposed methodology for setting occupational exposure limits for hydrocarbon solvents.
abstract: Occupational exposure limit (OEL) development for hydrocarbon solvents is complicated because most of these solvents have complex compositions and only a few representative constituents have been studied in detail. A proposed solution to this problem is to group constituents with similar physical, chemical, and toxicological properties and to assign "guidance values" to each group. A unique OEL can then be calculated for each solvent, using a reciprocal calculation procedure (RCP) based on the liquid composition. This procedure follows the American Conference of Governmental Industrial Hygienists' (ACGIH) generic advice for complex mixtures and is recommended by the U.K. Health and Safety Executive for OEL calculations by hydrocarbon solvent manufacturers. The RCP is justified, as the toxicological properties of the constituents are additive and the differences between the vapor and liquid compositions do not substantially affect the calculated exposure limits. The guidance values are based principally on acute central nervous system depression and eye and respiratory tract irritation, effects that are the most sensitive indicators of hydrocarbon solvent exposure. One benefit of this procedure is that it is a relatively simple but practical procedure that requires limited compositional information. Further, it provides OEL recommendations that are consistent with occupational experience and current regulatory advice. Groupings and guidance values are proposed, and sample calculations are provided.
authors.affiliation: Division of Toxicology and Environmental Sciences, ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey 08801, USA. richard.h.mckee@exxonmobil.com
authors.forename: Richard H
authors.initials: RH
authors.lastname: McKee
authors.forename: Arlean M
authors.initials: AM
authors.lastname: Medeiros
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Daughtrey
mesh_terms: D005128:Eye Diseases / Q000209:etiology; D017408:Guidelines as Topic; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects; D016273:Occupational Exposure; D012140:Respiratory Tract Diseases / Q000209:etiology; D018570:Risk Assessment; D012997:Solvents / Q000009:adverse effects; D020711:Threshold Limit Values
chemical_list: D006838:Hydrocarbons; D012997:Solvents