title: CD10 expression in colorectal carcinoma correlates with liver metastasis.
abstract: OBJECTIVE
  If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis.
  
  
  METHODS
  From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery, National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic and immunohistochemical factors (age, gender, tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis.
  
  
  RESULTS
  Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at least five years. Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and CD10 expression. Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis, and CD10 expression were significantly associated with liver metastases.
  
  
  CONCLUSIONS
  CD10 expression in colorectal carcinoma is a good predictor of liver metastasis.
authors.affiliation: Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sekine
authors.forename: Kimio
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Akasu
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Moriya
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Shimoda
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D005752:Gastric Mucins / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D055262:Mucin-2; D009077:Mucins / Q000032:analysis; D009362:Neoplasm Metastasis; D015260:Neprilysin / Q000032:analysis*; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor; D005752:Gastric Mucins; C524625:MUC2 protein, human; D055262:Mucin-2; D009077:Mucins; D015260:Neprilysin