title: Synchronous CIN 3 and cervical lymphoma: a case report and review of the literature.
abstract: Primary cervical lymphoma is rare, with less than 60 cases reported in the English literature, including a few cases of synchronous cervical intraepithelial neoplasia (CIN) with cervical lymphoma. We describe a 42-year-old woman with CIN 3 and malignant lymphoma of the cervix. The Papanicolaou cytology only revealed dysplastic cells of CIN 3, but not the malignant lymphoid cells. The histology of the cervix revealed diffuse infiltration of monotonous medium-sized lymphoid cells with dispersing tingible bodies, and a Burkitt's lymphoma in combination with a small CIN 3 lesion was diagnosed. Neither human papillomavirus nor Epstein-Barr virus was identified by polymerase chain reaction or in situ hybridization. The patient developed leukemic spreading and died soon after surgery.
authors.affiliation: Department of Pathology, Chang Gung University and Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan.
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Huang
authors.forename: Shih-Sung
authors.initials: SS
authors.lastname: Chuang
authors.forename: Hock-Liew
authors.initials: HL
authors.lastname: Eng
authors.forename: Chao-Cheng
authors.initials: CC
authors.lastname: Huanga
mesh_terms: D000328:Adult; D005260:Female; D005803:Genes, Immunoglobulin; D004854:Herpesvirus 4, Human; D006801:Humans; D017403:In Situ Hybridization; D008223:Lymphoma / Q000473:pathology*; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D065006:Papanicolaou Test; D027383:Papillomaviridae; D016133:Polymerase Chain Reaction; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology*