title: Persistent but reversible coma in encephalitis.
abstract: BACKGROUND
  Nontraumatic coma in adults has a poor prognosis, and late recovery of consciousness is unlikely. Functional recovery is usually extremely poor. However, a few nontraumatic comatose patients have shown late recovery of both awareness and function.
  
  
  METHODS
  A retrospective survey was conducted by reviewing the medical records of all inpatients to our department during the 1990s. Patients with persistent but reversible nontraumatic coma were identified according to the following criteria: (a) deep coma with a Glasgow Coma Scale (GCS) score of 7 or less on admission; (b) nontraumatic cause; (c) persistence of unconsciousness for longer than 1 month; and (d) subsequent recovery of GCS (total) to normal. The clinical spectrum of patients meeting these criteria was evaluated.
  
  
  RESULTS
  Six patients (ages 16-75 years) met the criteria. Viral encephalitis was diagnosed in five (two with herpes simplex virus, two with cytomegalovirus, and one with Epstein-Barr virus or cytomegalovirus). Two young female patients with encephalitis manifested extremely protracted coma persisting for 3 and 18 months, respectively. Complications included nonconvulsive status epilepticus in two patients and relative overdose of clonazepam in one patient.
  
  
  CONCLUSIONS
  Recognition of the clinical spectrum of persistent but reversible nontraumatic coma is important.
authors.affiliation: Department of Neurology,Tokai University School of Medicine, Kanagawa 259-1193, Japan. nagay001@is.icc.u-tokai.ac.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Nagayama
authors.forename: Kazushi
authors.initials: K
authors.lastname: Matsushima
authors.forename: Tomiko
authors.initials: T
authors.lastname: Nagayama
authors.forename: Yukito
authors.initials: Y
authors.lastname: Shinohara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D003071:Cognition; D003289:Convalescence; D018792:Encephalitis, Viral / Q000150:complications / Q000628:therapy; D005260:Female; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006566:Herpesviridae Infections / Q000150:complications / Q000628:therapy; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000628:therapy; D008579:Meningioma / Q000150:complications / Q000628:therapy; D008875:Middle Aged; D018458:Persistent Vegetative State / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology*; D020127:Recovery of Function; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000150:complications / Q000628:therapy