Influence of LY 300164 alone or in combination with carbamazepine or diphenylhydantoin on the body temperature in mice.
This study was aimed at evaluating the body temperature of mice following the injection of LY 300164, an AMPA/kainate receptor antagonist, alone or in combination with carbamazepine or diphenylhydantoin. LY 300164, injected alone at the dose of 2 mg/kg, produced a potent hypothermic effect between 15 and 30 min, or 60 and 90 min, after the drug administration. The combined treatment of LY 300164 (2 mg/kg) with diphenylhydantoin (3.6 mg/kg) resulted in a significant decrease of body temperature at the time period between 0 and 30 min, whilst LY 300164 (2 mg/kg) co-administered with carbamazepine (5 mg/kg) did not affect the animal temperature. Moreover, either diphenylhydantoin (11.8 mg/kg) or carbamazepine (15.8 mg/kg) injected alone exerted the hypothermic effects elicited at times ranging between 0 and 15 min, or 60 and 90 min, after the respective drug dose administration. In conclusion, hypothermia induced by LY 300164 along with its neuroprotective effects, may be useful in various brain conditions related with neuronal loss in which hypothermia offers some profitable effects, prolonging a survival rate of neurons in the central nervous system.
Luszczki
Jarogniew J
JJ
Department of Pathophysiology, Skubiszewski Medical University of Lublin.
Wierzchowska-Cioch
Ewa
E
Zwolan
Anna
A
Swiader
Mariusz J
MJ
Czuczwar
Stanisław J
SJ
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D002220:Carbamazepine / Q000494:pharmacology*; D005260:Female; D051379:Mice; D010672:Phenytoin / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*
D000927:Anticonvulsants; D018091:Receptors, AMPA; D001569:Benzodiazepines; D002220:Carbamazepine; D010672:Phenytoin; C085266:talampanel