title: Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia.
abstract: We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan. kirihara-tky@umin.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kirihara
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Keiko
authors.initials: K
authors.lastname: Maeda
authors.forename: Akinobu
authors.initials: A
authors.lastname: Hata
authors.forename: Miki
authors.initials: M
authors.lastname: Uetsuki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamasue
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rogers
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Akira
authors.initials: A
authors.lastname: Iwanami
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013850:Thinking