Expression of the Insulin Receptor Substrate 1 in primary tumors and lymph node metastases in breast cancer: correlations with Bcl-xL and Bax proteins.
In our previous investigation Insulin Receptor Substrate 1 (IRS-1) correlated with proliferation marker Ki-67 in human breast cancer. The aim of the present study was to assess relationships between IRS-1 expression and anti-apoptotic Bcl-xL as well as proapoptotic Bax proteins, assessed by immunohistochemistry, in primary tumors and lymph node metastases of breast cancer. IRS-1 is positively associated with both Bcl-xL and Bax in primary and metastatic tumors. Thus, our results could suggest that IRS-1 might affect turnover of cancer cells and breast cancer progression through activation of mitogenesis and participation in the regulation of the balance between anti- and proapoptotic pathways.
Koda
M
M
Department of Pathology, Medical University of Bialystok, Waszyngtona 13, 15-269 Bialystok, Poland. sulek@zeus.amb.edu.pl
Sulkowska
M
M
Kanczuga-Koda
L
L
Golaszewska
J
J
Kisielewski
W
W
Baltaziak
M
M
Wincewicz
A
A
Sulkowski
S
S
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D055504:Insulin Receptor Substrate Proteins; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D010750:Phosphoproteins / Q000096:biosynthesis*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis*; D051020:bcl-X Protein / Q000096:biosynthesis*
C494811:BCL2L1 protein, human; D014408:Biomarkers, Tumor; C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein