Canonical Wnt signaling: high-throughput RNAi widens the path.
The canonical Wnt signaling pathway is highly conserved in evolution, widely used throughout animal development, and frequently hyperactive in cancer. Although Wnt signaling has been the subject of extensive genetic analysis in the past, some 200 genes have now been identified as candidate modulators of this pathway by a recent study using high-throughput RNAi screening.
Brown
Anthony M C
AM
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, and Strang Cancer Prevention Center, New York, NY 10021, USA. amcbrown@med.cornell.edu
D000818:Animals; D004331:Drosophila melanogaster / Q000378:metabolism; D006801:Humans; D034622:RNA Interference; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism
D051153:Wnt Proteins; D051176:beta Catenin