title: Vaccine-induced CD8+ central memory T cells in protection from simian AIDS.
abstract: Critical to the development of an effective HIV vaccine is the identification of adaptive immune responses that prevent infection or disease. In this study we demonstrate in a relevant nonhuman primate model of AIDS that the magnitude of vaccine-induced virus-specific CD8(+) central memory T cells (T(CM)), but not that of CD8(+) effector memory T cells, inversely correlates with the level of SIVmac251 replication, suggesting their pivotal role in the control of viral replication. We propose that effective preventive or therapeutic T cell vaccines for HIV-1 should induce long-term protective central memory T cells.
authors.affiliation: Animal Models and Retroviral Vaccines Section and National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Vaccari
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Trindade
authors.forename: David
authors.initials: D
authors.lastname: Venzon
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zanetti
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Franchini
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015683:Gene Products, gag / Q000008:administration & dosage / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D016056:Immunodominant Epitopes / Q000008:administration & dosage / Q000276:immunology; D007156:Immunologic Memory / Q000187:drug effects; D016130:Immunophenotyping; D008251:Macaca; D018449:SAIDS Vaccines / Q000008:administration & dosage / Q000494:pharmacology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000628:therapy*; D015302:Simian Immunodeficiency Virus / Q000187:drug effects; D014766:Viremia / Q000188:drug therapy; D014779:Virus Replication / Q000187:drug effects
chemical_list: D015683:Gene Products, gag; D016056:Immunodominant Epitopes; D018449:SAIDS Vaccines