Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia.
We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.
Kirihara
Kenji
K
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan. kirihara-tky@umin.ac.jp
Araki
Tsuyoshi
T
Kasai
Kiyoto
K
Maeda
Keiko
K
Hata
Akinobu
A
Uetsuki
Miki
M
Yamasue
Hidenori
H
Rogers
Mark A
MA
Kato
Nobumasa
N
Iwanami
Akira
A
D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013850:Thinking