title: Chemokines: their role in rheumatoid arthritis.
abstract: Chemokines are small proteins that can act on cells that express matching receptors. They are best known for their role in migration of cells, especially immune cells. Chemokine/chemokine-receptor pairs are often functionally categorized into three groups: inflammatory, homeostatic, and angiogenic/angiostatic, although functions sometimes overlap. Interfering with the interaction between chemokines and their receptors is currently under investigation as a therapeutic strategy in rheumatoid arthritis.
authors.affiliation: Division of Clinical Immunology and Rheumatology, F4-218, Academic Medical Center/University of Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands. c.e.vergunst@amc.nl
authors.forename: Clarissa E
authors.initials: CE
authors.lastname: Vergunst
authors.forename: Paul P
authors.initials: PP
authors.lastname: Tak
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D019707:Receptors, Chemokine / Q000378:metabolism
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine