Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland.
The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.
Hens
Julie R
JR
Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University School of Medicine, and Anlyan Center for Medical Research and Education, New Haven, Connecticut, USA. julie.hens@yale.edu
Wysolmerski
John J
JJ
D000818:Animals; D001940:Breast / Q000196:embryology / Q000254:growth & development; D047108:Embryonic Development; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology; D005260:Female; D006801:Humans; D007774:Lactation; D008321:Mammary Glands, Animal / Q000196:embryology* / Q000254:growth & development*; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D051379:Mice; D008892:Milk / Q000378:metabolism; D009024:Morphogenesis; D044162:Parathyroid Hormone-Related Protein / Q000502:physiology
D044162:Parathyroid Hormone-Related Protein