title: [Histoplasmoma as isolated central nervous system lesion in an immunocompetent patient].
abstract: The cerebral lesions are uncommon in patients with histoplasmosis, occurring more frequently in the disseminated form of the disease. Rarely, the disease may present as a histoplasmoma, simulating a neoplastic lesion. The histoplasmoma as the only manifestation of this infection in immunocompetent patients is even rarer. This case report describes a 13 year-old male patient with headache, vomit, low visual acuity and auditive deficit on the left, and paresis on the right. The magnetic resonance image showed an expansible lesion in the thalamic, hypothalamic, and chiasmatic regions, which showed ring enhancement. The stereotactic biopsy was performed and the histological diagnosis of histoplasmosis was defined. The treatment was initiated with fluconazole. The patient showed important clinical improvement after 6 months.
authors.affiliation: Serviço de Radiologia Médica e Diagnóstico por Imagem, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. gasparetto@hotmail.com
authors.forename: Emerson L
authors.initials: EL
authors.lastname: Gasparetto
authors.forename: Arnolfo de
authors.initials: Ad
authors.lastname: Carvalho Neto
authors.forename: James
authors.initials: J
authors.lastname: Alberton
authors.forename: Taisa
authors.initials: T
authors.lastname: Davaus
authors.forename: Mara Albonei D
authors.initials: MA
authors.lastname: Pianovski
authors.forename: Erica
authors.initials: E
authors.lastname: Yamauchi
authors.forename: Luiz F Bleggi
authors.initials: LF
authors.lastname: Torres
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy / Q000379:methods; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015725:Fluconazole / Q000627:therapeutic use; D006658:Histoplasma; D006660:Histoplasmosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013238:Stereotaxic Techniques
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole