title: Sensitization to airborne environmental allergens: unresolved issues.
abstract: Despite considerable advances in identifying the environmental agents that trigger allergy and the immunological mechanisms involved, progress in developing effective treatments remains frustratingly slow. Is it time to rethink some of the paradigms guiding this research?
authors.affiliation: Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, 6009, Western Australia. patrick@ichr.uwa.edu.au
authors.forename: P G
authors.initials: PG
authors.lastname: Holt
authors.forename: W R
authors.initials: WR
authors.lastname: Thomas
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects* / Q000276:immunology; D000485:Allergens / Q000009:adverse effects* / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000009:adverse effects* / Q000276:immunology; D016207:Cytokines / Q000037:antagonists & inhibitors; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000628:therapy*; D007114:Immunization; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D000393:Air Pollutants; D000485:Allergens; D000941:Antigens; D016207:Cytokines