title: ONTOFUSION: ontology-based integration of genomic and clinical databases.
abstract: ONTOFUSION is an ontology-based system designed for biomedical database integration. It is based on two processes: mapping and unification. Mapping is a semi-automated process that uses ontologies to link a database schema with a conceptual framework-named virtual schema. There are three methodologies for creating virtual schemas, according to the origin of the domain ontology used: (1) top-down--e.g. using an existing ontology, such as the UMLS or Gene Ontology--, (2) bottom-up--building a new domain ontology-- and (3) a hybrid combination. Unification is an automated process for integrating ontologies and hence the database to which they are linked. Using these methods, we employed ONTOFUSION to integrate a large number of public genomic and clinical databases, as well as biomedical ontologies.
authors.affiliation: Biomedical Informatics Group, Artificial Intelligence Laboratory, School of Computer Science, Universidad Politecnica de Madrid, 28660 Boadilla del Monte, Spain. dperez@infomed.dia.fi.upm.es
authors.forename: D
authors.initials: D
authors.lastname: Pérez-Rey
authors.forename: V
authors.initials: V
authors.lastname: Maojo
authors.forename: M
authors.initials: M
authors.lastname: García-Remesal
authors.forename: R
authors.initials: R
authors.lastname: Alonso-Calvo
authors.forename: H
authors.initials: H
authors.lastname: Billhardt
authors.forename: F
authors.initials: F
authors.lastname: Martin-Sánchez
authors.forename: A
authors.initials: A
authors.lastname: Sousa
mesh_terms: D003625:Data Collection; D003628:Database Management Systems; D016208:Databases, Factual; D030541:Databases, Genetic; D006801:Humans; D008490:Medical Informatics; D014584:User-Computer Interface