Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection.
To determine the role of host immune responses in H. pylori infection, we examined the relationship between gastric mucosal IL-8 levels and histological gastritis in patients with H. pylori infection. Biopsy tissue obtained from 99 patients were homogenizedand mucosal IL-8 levels measured by ELISA. The gastric mucosal IL-8 levels in both the antrum and corpus were higher in patients with H. pylori than in H. pyloi negativepatients. IL-8 levels in the corpus but not the antrum correlated with the severity of the atrophy. The IL-1B polymorphism had no influence on the degree of IL-8 production. These findings indicate that IL-8 production is independent of IL-1B polymorphisms and IL-8 may play an important role in the development of atrophic gastritis.
Xuan
Jiang
J
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Deguchi
Ryuzo
R
Yanagi
Hidetaka
H
Ozawa
Hideki
H
Urano
Tetsuya
T
Ogawa
Yoshiaki
Y
Fukuda
Ryuuki
R
Kojima
Seiichiro
S
Nishina
Makoto
M
Sudo
Hiroshi
H
Kijima
Hiroshi
H
Koga
Yasuhiro
Y
Takagi
Atsushi
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration / Q000276:immunology; D011110:Polymorphism, Genetic
D007375:Interleukin-1; D016209:Interleukin-8