[Impedance effects of interleukin-6 on cyclophosphamide-induced hematopoietic damnification in dogs].
The aim of this study is to evaluate the effect of Interleukin-6 on cyclophosphamide-induced hematopoietic damnification. The doses of Interleukin-6 in 3 different regimens were hypodermally injected into dogs for 7 days respectively to establish the cyclophosphamide-induced hematopoietic damnification model. The effect of Interleukin-6 on the production of platelets and the amount of other cells in the dogs' bone marrow were determined on the 21st day. The results showed that Interleukin-6 significantly alleviated the reduction of platelet count and recovered the platelets level faster. The impedance effects of Interleukin-6 directed against hematopoietic damnification of bone marrow and spleen were shown by pathological examination. These suggest that the Interleukin-6 can significantly impede cyclophosphamide-induced hematopoietic damnification.
Yin
Hailin
H
Laboratory Animal Center of Sichuan University, Chengdu 610041, China.
He
Xueling
X
Bao
Xu
X
Liu
Xuexu
X
Yang
Guangwu
G
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D003520:Cyclophosphamide / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D015850:Interleukin-6 / Q000494:pharmacology* / Q000627:therapeutic use; D007970:Leukopenia / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control*
D015850:Interleukin-6; D003520:Cyclophosphamide