New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778.
Four new antibiotics, sesquicillins B to E were isolated from the culture broth of Albophoma sp. FKI-1778 together with known sesquicillin (sesquicillin A in this paper). The structures of sesquicillins were elucidated by spectroscopic studies including various NMR experiments. All sesquicillins have a common pyrano-diterpene skeleton. Sesquicillins showed moderate inhibitory activity against the growth of Artemia salina (brine shrimps) and Jurkat cells.
Uchida
Ryuji
R
The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 1088641, Japan.
Imasato
Rie
R
Yamaguchi
Yuichi
Y
Masuma
Rokuro
R
Shiomi
Kazuro
K
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001156:Artemia; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007313:Insecta; D007306:Insecticides / Q000378:metabolism / Q000494:pharmacology*; D019169:Jurkat Cells; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009281:Naphthalenes / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D007306:Insecticides; D009281:Naphthalenes; C113328:sesquicillin