title: Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment.
abstract: We investigated the correlation between the apolipoprotein E varepsilon4 allele (apoE epsilon4) carrier status, a major risk factor of Alzheimer's disease (AD), and levels of tau protein phosphorylated at threonine 231 (P-tau(231P)) in cerebrospinal fluid (CSF) in predementia and clinical stages of AD and healthy controls (HC). Thirty-one subjects with mild cognitive impairment (MCI) who had converted to AD during follow-up were included, as well as 71 AD patients, and 29 HC subjects. In MCI, but not in AD and HC, CSF P-tau(231P) levels were significantly higher in apoE epsilon4 carriers compared to non-carriers (p<0.001). Controlling for disease duration, the apoE epsilon4 effect on P-tau(231P) remained significant. Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects.
authors.affiliation: Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany. katharina.buerger@med.uni-muenchen.de
authors.forename: Katharina
authors.initials: K
authors.lastname: Buerger
authors.forename: Stefan J
authors.initials: SJ
authors.lastname: Teipel
authors.forename: Raymond
authors.initials: R
authors.lastname: Zinkowski
authors.forename: Trey
authors.initials: T
authors.lastname: Sunderland
authors.forename: Niels
authors.initials: N
authors.lastname: Andreasen
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Michael
authors.initials: M
authors.lastname: Ewers
authors.forename: John
authors.initials: J
authors.lastname: DeBernardis
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.forename: Daniel
authors.initials: D
authors.lastname: Kerkman
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Du
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D006580:Genetic Carrier Screening / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013548:Sweden / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D016875:tau Proteins
chemical_list: D001057:Apolipoproteins E; C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D016875:tau Proteins