title: Renal scarring in spinal cord injury: a progressive process?
abstract: METHODS
  A retrospective analysis.
  
  
  OBJECTIVE
  To examine the natural history of renal scarring in the spinal cord injured population.
  
  
  METHODS
  United Kingdom.
  
  
  METHODS
  All spinal cord injured patients with renal scars at our establishment were considered eligible. A total of 27 patients with renal scars were identified. No patient had renal scarring at presentation on radiological imaging. All patients had annual renal imaging with a mean follow up period of 19.1 years. The presence of new scars was considered as evidence of progression.
  
  
  RESULTS
  In all, 59% of kidneys developed renal scars with a mean time interval between spinal injury and renal scar development of 13 years. Of these kidneys with scars, only 15.6% demonstrated progression of the scarring process. There were no deaths due to renal causes.
  
  
  CONCLUSIONS
  The aetiology of renal scarring is multifactorial. The findings of this study suggest that renal scarring in the spinal cord injured population is predominantly a nonprogressive process once a scar has developed. This is in concordance with the belief that renal scarring in the paediatric population with vesicoureteric reflux is also a stable, nonprogressive process.
authors.affiliation: Department of Urology, St James's University Hospital, Leeds, West Yorkshire, UK.
authors.forename: I
authors.initials: I
authors.lastname: Edhem
authors.forename: S C W
authors.initials: SC
authors.lastname: Harrison
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000534:rehabilitation; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods; D014546:Urinary Catheterization / Q000009:adverse effects*; D014570:Urologic Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D014949:Wounds, Nonpenetrating / Q000000981:diagnostic imaging / Q000209:etiology*