[Effects of atorvastatin on LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells].
OBJECTIVE
To investigate the effects of atorvastatin on LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells (A549).


METHODS
The supernates of LPS-induced cultured human pulmonary epithelial cells from different intervention groups were collected to measure the concentrations of PGE2 and IL-6 by enzyme-linked immunosorbent assay.


RESULTS
The concentrations of PGE2 and IL-6 in supernates of LPS-induced human pulmonary epithelial cells were significantly higher than those in the control group (P < 0.05) at different time-points. The concentrations of PGE2 and IL-6 in supernates of atorvastatin intervention groups at different levels were significantly lower than those in non-intervention group (P < 0.05).


CONCLUSIONS
Atorvastatin decreased LPS-induced PGE2 and IL-6 secretions in human pulmonary epithelial cells (A549), which suggests that statins have anti-inflammatory properties on human pulmonary epithelial cells.
Wu
Shang-Jie
SJ
Department of Pulmonary Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China. wu_shangjie@hotmail.com
Zhao
Shui-Ping
SP
D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000069059:Atorvastatin; D002460:Cell Line; D015232:Dinoprostone / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006538:Heptanoic Acids / Q000494:pharmacology*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008168:Lung / Q000166:cytology*; D011758:Pyrroles / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D015850:Interleukin-6; D008070:Lipopolysaccharides; D011758:Pyrroles; D000069059:Atorvastatin; D015232:Dinoprostone