title: Catalytic enantioselective addition of indoles to arylnitroalkenes: an effective route to enantiomerically enriched tryptamine precursors.
abstract: A new valuable catalytic protocol for the preparation of synthetically useful beta-indolyl nitro compounds bearing benzhydryl stereocenters is presented. The combined use of catalytic amounts of a commercially available chiral [SalenAlCl] complex and pyridine allowed, for the Friedel-Crafts alkylation reaction of indoles with aromatic nitro-olefins to be carried out in good yields and enantioselectivity (up to 63% ee).
authors.affiliation: Dipartimento di Chimica G. Ciamician, Alma Mater Studiorum, University of Bologna, Italy. marco.bandini@unibo.it
authors.forename: Marco
authors.initials: M
authors.lastname: Bandini
authors.forename: Andrea
authors.initials: A
authors.lastname: Garelli
authors.forename: Matteo
authors.initials: M
authors.lastname: Rovinetti
authors.forename: Simona
authors.initials: S
authors.lastname: Tommasi
authors.forename: Achille
authors.initials: A
authors.lastname: Umani-Ronchi