[Clinical value of morphologic and functional parameters of blood mononuclear leukocytes in patients with rheumatoid arthritis].
The immunologic study of 412 patient with rheumatoid arthritis (RA) and 52 person of control group has been carried out. The correlation was established between activity of RA and increase in morphologic and functional activity of CD4+-, CD8+- and CD19+-lymphocytes, enhancement of proliferate response and ability to Fas-induced apoptosis of T-cells (r - from 0,5 to 0,81) and between the development of severe systemic complication and increase in percentage of CD8+-lymphocytes with large homogenous nucleoli (r=+0,71+/-0,08), mean diameter of CD8+-lymphocytes nucleus (r=+0,61+/-0,08) and mononuclear leukocytes proliferate response to FGA (r=+0,56+/-0,07). The step based system of assessment of cell immunity disturbances and the criteria of the evaluation of risks of the development of systemic complication in patients with RA were established on the above mentioned parameters development prognosis based on their immune parameters.
Petrov
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D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D017209:Apoptosis / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology*; D022003:Cell Nucleus Structures; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D015703:Antigens, CD