[Related inflammation markers among different types of coronary heart disease].
OBJECTIVE
To study the relationship between levels of activity of NF-kappaB p65, plasma soluble inter-cellular adhesion molecule-1, C-reactive protein on plaque stability, and different types of coronary heart disease.


METHODS
We measured the levels of plasma soluble inter-cellular adhesion molecule-1 and C-reactive protein by enzyme-linked immunosorbant assay and the activity of NF-kappaB p65 in peripheral blood lymocytes immunohistochemically.


RESULTS
Compared with the stable angina and the control group, the baseline activity of NF-kappaB p65, sICAM-1 and C-reactive protein was significantly elevated in the acute myocardial infarction and the unstable angina (P <0.01). After 3 month follow-up, the levels of activity of NF-kappaB p65 and sICAM-1 were unchanged (P > 0.05). In all groups, C-reactive proteins were lowered at the review (P <0.01).


CONCLUSIONS
The levels of activity of NF-kappaB p65, sICAM-1 and C-reactive protein are related to the plaque stability among different types of coronary heart disease. NF-kappaB p65, and sICAM-1 are not affected by the acute event. These plasma markers may be important risk factors for the development of the acute coronary syndrome.
Luo
Ying
Y
Department of Gerontology, Xiangya Hospital, Central South University, Changsha, China. XLYL@medmail.com
Xie
Xiu-Mei
XM
Liu
Hui-Xia
HX
D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D000789:Angina, Unstable / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D016328:NF-kappa B / Q000097:blood*
D016328:NF-kappa B; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein