Effects of anesthesia upon 18F-FDG uptake in rhesus monkey brains.
The kinetics of 18F-fluorodeoxyglucose (18F-FDG) in the monkey brain were monitored, and comparisons were made between the conscious state and when under ketamine and pentobarbital anesthesia. Rhesus monkeys were intravenously injected with 18F-FDG and followed by 60 min of PET scanning. In the conscious state, the 18F-FDG concentration reached a plateau 5 min after intravenous injection. Under ketamine anesthesia, the 18F-FDG concentration gradually increased with time in all monitored regions. At 60 min after injection, the concentration in the striatum was about 3.2 times greater than that in the conscious state, and about 4.5 times greater in the cerebral cortex. Under pentobarbital anesthesia, the 18F-FDG concentration in the occipital cortex was slightly lower. These findings demonstrate that 18F-FDG concentration in the monkey brain is significantly affected by anesthesia. The results also imply the existence of a short-term regulation mechanism for hexokinase activity in intact monkey brain.
Itoh
Takashi
T
Center for Information and Sciences, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan. itoh@nms.ac.jp
Wakahara
Shunichi
S
Nakano
Takayuki
T
Suzuki
Kazutoshi
K
Kobayashi
Kaoru
K
Inoue
Osamu
O
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000758:Anesthesia / Q000379:methods; D000778:Anesthetics, Dissociative / Q000008:administration & dosage; D000818:Animals; D016477:Artifacts; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007649:Ketamine / Q000008:administration & dosage*; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D008657:Metabolic Clearance Rate; D010424:Pentobarbital / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
D000759:Adjuvants, Anesthesia; D000778:Anesthetics, Dissociative; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D007649:Ketamine; D010424:Pentobarbital