title: Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial.
abstract: OBJECTIVE
  Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn's disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn's disease.
  
  
  METHODS
  Fifty children with a paediatric Crohn's disease activity index (PCDAI)>20 were randomly assigned to receive 50% (PEN) or 100% (TEN) of their energy requirement as elemental formula for six weeks. The PEN group was encouraged to eat an unrestricted diet while those receiving TEN were not allowed to eat. The primary outcome was achievement of remission (PCDAI<10). Secondary analyses of changes in erythrocyte sedimentation rate (ESR), C reactive protein, albumin, and platelets were performed to look for evidence of anti-inflammatory effects.
  
  
  RESULTS
  Remission rate with PEN was lower than with TEN (15% v 42%; p=0.035). Although PCDAI fell in both groups (p=0.001 for both), the reduction was greater with TEN (p=0.005). Moreover, the fall in PCDAI with PEN was due to symptomatic and nutritional benefits. With both treatments there were significant improvements in relation to abdominal pain, "sense of wellbeing", and nutritional status. However, only TEN led to a reduction in diarrhoea (p=0.02), an increase in haemoglobin and albumin, and a fall in platelets and ESR.
  
  
  CONCLUSIONS
  TEN suppresses inflammation in active Crohn's disease but PEN does not. This suggests that long term nutritional supplementation, although beneficial to some patients, is unlikely to suppress inflammation and so prevent disease relapse.
authors.affiliation: Birmingham Children's Hospital, Birmingham B4 6NH, UK.
authors.forename: T
authors.initials: T
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Macdonald
authors.forename: S M
authors.initials: SM
authors.lastname: Hill
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: M S
authors.initials: MS
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D017195:Adolescent Nutritional Physiological Phenomena; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D003424:Crohn Disease / Q000097:blood / Q000628:therapy*; D002149:Energy Intake; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D005526:Food, Formulated / Q000032:analysis; D006801:Humans; D008297:Male; D012074:Remission Induction; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002097:C-Reactive Protein