title: Use of rifampicin and ciprofloxacin combination therapy after surgical debridement in the treatment of early manifestation prosthetic joint infections.
abstract: Prosthetic joint infections are difficult to eradicate, and antibiotic and surgical treatment strategies lack standardisation. The present study followed 29 patients (median age 72 years, median American Society of Anesthesia score of two) with early prosthetic joint infections. Treatment consisted of device retention, surgical debridement and therapy with rifampicin and ciprofloxacin for 3 months. This treatment regimen failed in five patients during the study, with a median observation period of 674 days. The results of this study confirm the findings of the only previous study on device retention with antibiotic treatment.
authors.affiliation: Medical Department, Akershus University Hospital, Nordbyhagen, Norway. jan.erik.berdal@ahus.no
authors.forename: J-E
authors.initials: JE
authors.lastname: Berdal
authors.forename: I
authors.initials: I
authors.lastname: Skråmm
authors.forename: P
authors.initials: P
authors.lastname: Mowinckel
authors.forename: P
authors.initials: P
authors.lastname: Gulbrandsen
authors.forename: J V
authors.initials: JV
authors.lastname: Bjørnholt
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003646:Debridement; D004359:Drug Therapy, Combination; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D012293:Rifampin