title: [Expression and clinical significance of CD1a+ dendritic cells in glottic squamous cell carcinoma].
abstract: OBJECTIVE
  Dendritic cells (DCs) are the most important antigen-presenting cells. CD1a, a marker of immature DCs, plays a role in tumorigenesis. This study was designed to explore the correlation of CD1a(+) DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma.
  
  
  METHODS
  Clinical and follow-up data of 111 patients with glottic squamous cell carcinoma were analyzed retrospectively. The expression of CD1a(+) DCs in the 111 specimens of glottic squamous cell carcinoma and 17 specimens of non-tumor tissue was detected by immunohistochemistry. Correlations of CD1a(+) DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma were analyzed.
  
  
  RESULTS
  Positive rates of CD1a(+) DCs were 59.46% in glottic squamous cell carcinoma tissues, and 0 in non-tumor tissues; it was significantly higher in well-differentiated group than in moderately-and poorly-differentiated group [71.43% (55/77) vs. 28.57% (11/34), P<0.05], higher in T1-T2 group than in T3-T4 group [67.16% (45/67) vs. 47.73% (21/44), P<0.05], and higher in non-recurrence group than in local recurrence group [65.06% (54/83) vs. 42.86% (12/28), P<0.05].
  
  
  CONCLUSIONS
  The lower pathologic degree and higher T stage of glottic squamous cell carcinoma, the lower expression of CD1a(+) DCs. The positive rate of CD1a(+) DCs is low in recurrent glottic tumor. High expression of CD1a(+) DCs may indicate better prognosis of glottic squamous cell carcinoma.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P.R. China. chenwenkuan@163.com
authors.forename: Wen-Kuan
authors.initials: WK
authors.lastname: Chen
authors.forename: Fu-Jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Guo-Hao
authors.initials: GH
authors.lastname: Wu
authors.forename: Zhu-Ming
authors.initials: ZM
authors.lastname: Guo
authors.forename: Mao-Wen
authors.initials: MW
authors.lastname: Wei
authors.forename: An-Kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jie-Hua
authors.initials: JH
authors.lastname: He
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D018949:Antigens, CD1 / Q000378:metabolism*; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D018949:Antigens, CD1; D014408:Biomarkers, Tumor; C419393:CD1a antigen