[Comparing the actions of the three flavone ingredients in choerospondias axillaris on arrhythmias induced by aconitine].
OBJECTIVE
To compare the actions of the three flavone ingredients in choerospondias axillaris on arrhythmias Induced by aconitine.


METHODS
Langendorff perfuse was applied in the experiment, the antiarrhythmic action was to study by using aconitine on the the isolated heart; The antiarrhythmic action of the three flavone ingredients in choerospondias axillaris was to study by using i.v. aconitine in rat to induce arrhythmias.


RESULTS
Compared with the NS group, sample 1 and sample 2 both significantly prolonged the beginning time of VF of isolated heart and increased the dosage of aconitine, sample 3 reduced the beginning time of VF of isolated heart and decreased the dosage of aconitine, sample 1 and sample 2 both greatly prolonged the beginning time of VE, VT, VF, HA; sample 3 greatly reduced the beginning time of VT,VF. The actions of the three samples were in a concentration-dependent way.


CONCLUSIONS
Sample 1 and sample 2 both resisted the occurrence of arrhythmias induced by aconitine, sample 3 markedly promoted the occurrence of arrhythmias induced by aconitine.
Wang
Feng-Hua
FH
The Third Affiliated Hospital of Inner Mongolia Medical College, Baotou 014010, China.
Yang
Yu-Mei
YM
Xu
Ji-Hui
JH
Qin
Jian-Min
JM
Ying
Kang
K
Zhang
Chang-Zai
CZ
Song
Yi-Ting
YT
Yu
Teng-Fei
TF
D000157:Aconitine; D027926:Anacardiaceae / Q000737:chemistry; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D047309:Flavones / Q000302:isolation & purification / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000889:Anti-Arrhythmia Agents; D047309:Flavones; D000157:Aconitine