title: Screening program of prostate cancer at Tokai University Hospital: characterization of prostate-specific antigen measurement.
abstract: A total of 67,214 men participated in screening for prostate cancer (PC) using serum prostate-specific antigen (PSA) from April 1996 to March 2003 at Tokai University Hospital. In 3.5% (2330 / 67,214) of the men, an elevated PSA level (> 4.0 ng/ml) was found and 68.1% (1586/2330) of these subjects were examined at our Urological Outpatient Clinic. Re-testing of PSA showed that 8.4% (133/1586) had a normal level. Needle biopsy of the prostate was performed in 45.2% (633/1453) of the remaining men. As a result, 142 PCs were found and the detection rate was 0.2% (142 / 67,214). The age of the patients with PC was over 50 years. During this period, 135 individuals with voiding dysfunction were also diagnosed as having PC. Comparison of the patients detected by screening with those found at the outpatient clinic revealed significant differences of the age (64.8 vs. 71.9 years, p < 0.0001), serum PSA level (14.6 vs. 154.9 ng/ml, p < 0.0001), and clinical stage (p < 0.0001). In conclusion, a health screening program that includes serum PSA testing is useful for detection of PC at an earlier stage and in younger individuals. We recommend that all men aged 50 years or older undergo testing for PSA to detect PC at an early stage.
authors.affiliation: Department of Urology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuda
authors.forename: Hideshi
authors.initials: H
authors.lastname: Miyakita
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Sunao
authors.initials: S
authors.lastname: Shoji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Takuo
authors.initials: T
authors.lastname: Kono
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Masanori
authors.initials: M
authors.lastname: Shima
authors.forename: Yukio
authors.initials: Y
authors.lastname: Usui
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Masuda
authors.forename: Hidechika
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Teppei
authors.initials: T
authors.lastname: Ogawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Honma
authors.forename: R Yoshiyuki
authors.initials: RY
authors.lastname: Osamura
authors.forename: Toshiro
authors.initials: T
authors.lastname: Terachi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen