Formation and characterization of stable human serum albumin-tris-malonic acid [C60]fullerene complex.
The preparation and characterization of the stable human serum albumin (HSA)-C3 isomer of tris-malonic acid [C60]fullerene complex is reported. Other than the anti-fullerene antibody, a stable protein-fullerene complex with a native protein has never been observed. This study may provide valuable answers to the growing concern regarding the effects of carbonaceous nanomaterials on human health on one hand and, on the other, may lead to the development of novel antioxidant therapeutic agents, radiopharmaceuticals, and components for bioelectronic devices.
Belgorodsky
Bogdan
B
School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
Fadeev
Ludmila
L
Ittah
Varda
V
Benyamini
Hadar
H
Zelner
Stanislav
S
Huppert
Dan
D
Kotlyar
Alexander B
AB
Gozin
Michael
M
D002850:Chromatography, Gel; D045304:Cytochromes c / Q000737:chemistry / Q000378:metabolism; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D008314:Malonates / Q000737:chemistry*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D012709:Serum Albumin / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism; D014325:Tromethamine / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000737:chemistry / Q000378:metabolism
D037741:Fullerenes; D008314:Malonates; D012709:Serum Albumin; D014325:Tromethamine; D045304:Cytochromes c; C030290:malonic acid; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C069837:fullerene C60