Relation of age, severity of illness, and hemodynamics with brain natriuretic peptide levels in patients <20 years of age with heart disease.
Brain natriuretic peptide (BNP) levels were obtained before cardiac catheterization in 193 pediatric patients with a variety of cardiac lesions. Age and functional status had strong relations to BNP values, with elevations of BNP levels associated with increasing functional disability and decreasing age. Mild but statistically significant correlations were found between BNP levels and right-sided cardiac pressures. In patients with volume-overloaded ventricles, BNP correlated with the degree of overcirculation.
Lin
Nancy C
NC
Division of Pediatric Cardiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Landt
Michael L
ML
Trinkaus
Kathryn M
KM
Balzer
David T
DT
Kort
Henry W
HW
Canter
Charles E
CE
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index
D020097:Natriuretic Peptide, Brain