Use of paired serum samples for serodiagnosis of typhoid fever.
Using an enzyme-linked immunosorbent assay we demonstrate that, in adult patients with typhoid fever, the sensitivity of a serological test based on the detection of anti-lipopolysaccharide immunoglobulin G is increased when used with paired serum samples taken 1 week apart.
House
Deborah
D
Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, South Kensington, UK. d.house@ic.ac.uk
Chinh
Nguyen T
NT
Diep
To S
TS
Parry
Christopher M
CM
Wain
John
J
Dougan
Gordon
G
White
Nicholas J
NJ
Hien
Tran Tinh
TT
Farrar
Jeremy J
JJ
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008070:Lipopolysaccharides / Q000276:immunology*; D012485:Salmonella typhi / Q000276:immunology; D012698:Serologic Tests; D013997:Time Factors; D014435:Typhoid Fever / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D008070:Lipopolysaccharides