[Analysis of group B streptococcal gene scaAB encoding the protein involved in adherence and aggregation].
The portion of group B streptococcal (GBS) sequence encoding the ABC transport system was cloned and sequenced. The genetic region under study included scaAB gene, which was capable of encoding for putative adherence and aggregation factor, and scaR, which was encoding for putative represser. After the insertional inactivation of scaAB gene on the GBS chromosome streptococci increased the tendency for aggregation. The level of GBS adherence to vaginal epithelium was also different after scaAB inactivation. GBS sea operon was compared to similar ABC encoding bacterial operons.
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D018829:Adhesins, Bacterial / Q000235:genetics*; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004848:Epithelium / Q000382:microbiology; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D016254:Mutagenesis, Insertional; D017422:Sequence Analysis, DNA; D013292:Streptococcus agalactiae / Q000235:genetics* / Q000472:pathogenicity*; D014621:Vagina / Q000166:cytology; D014774:Virulence / Q000235:genetics
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins