title: The effect of logarithmic compression on estimation of the Nakagami parameter for ultrasonic tissue characterization: a simulation study.
abstract: Previous studies have demonstrated that the Nakagami parameter estimated using the envelopes of backscattered ultrasound is useful in detecting variations in the concentration of scatterers in tissues. The signal processing in those studies was linear, whereas nonlinear logarithmic compression is routinely employed in existing ultrasonic scanners. We therefore explored the effect of the logarithmic compression on the estimation of the Nakagami parameter in this study. Computer simulations were used to produce backscattered signals of various scatterer concentrations for the estimation of the Nakagami parameters before and after applying the logarithmic compression on the backscattered envelopes. The simulated results showed that the logarithmic compression would move the statistics of the backscattered envelopes towards post-Rayleigh distributions for most scatterer concentrations. Moreover, the Nakagami parameter calculated using compressed backscattered envelopes is more sensitive than that calculated using uncompressed envelopes in differentiating variations in the scatterer concentration, making the former better at quantifying the scatterer concentration in biological tissues.
authors.affiliation: Department of Biomedical Engineering, Yuan Pei Institute of Science and Technology 306, Yuanpei St, Hsin Chu, 30015, Taiwan.
authors.forename: Po-Hsiang
authors.initials: PH
authors.lastname: Tsui
authors.forename: Shyh-Hau
authors.initials: SH
authors.lastname: Wang
authors.forename: Chih-Chung
authors.initials: CC
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D008954:Models, Biological; D014465:Ultrasonics; D014463:Ultrasonography