title: Passive cigarette smoking increases isoprostane formation.
abstract: Passive smoking has been demonstrated to exert a variety of deleterious effects eventually resulting in vascular damage. Isoprostanes, a reliable marker of in vivo oxidation injury, have been shown to increase in active cigarette smoking. Data for passive smoking are lacking. We were examining the isoprostane 8-epi-PGF2alpha in 12 smokers and non-smokers exposed daily to passive cigarette smoke for 12 days. Plasma samples stored at liquid nitrogen from people having been examined earlier were used. Prevalues of 8-epi-PGF2alpha are higher in cigarette smokers. Exposure to passive smoking causes a significant increase in 8-epi-PGF2alpha in non-smokers, while in smokers there is only a trendwise increase. After repeated passive smoke exposure, 8-epi-PGF2alpha in non-smokers approaches the respective values of smokers. There is a significant correlation of 8-epi-PGF2alpha to the thromboxane (plasma, serum, conversion from exogenous precursor, 11-dehydro-TXB2) parameters (MDA, HHT- conversion) examined in these patients before. The findings document a significant temporary increase in in vivo oxidation injury due to passive smoke favouring development and/or progression of vascular disease.
authors.affiliation: Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Austria.
authors.forename: Hossein
authors.initials: H
authors.lastname: Ahmadzadehfar
authors.forename: Anthony
authors.initials: A
authors.lastname: Oguogho
authors.forename: Yannis
authors.initials: Y
authors.lastname: Efthimiou
authors.forename: Harald
authors.initials: H
authors.lastname: Kritz
authors.forename: Helmut
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D028421:Isoprostanes / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D013929:Thromboxane B2 / Q000097:blood; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D014029:Tobacco Use Disorder / Q000097:blood*
chemical_list: D028421:Isoprostanes; D014028:Tobacco Smoke Pollution; D013929:Thromboxane B2