title: Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery.
abstract: Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and "lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs).
authors.affiliation: UMR CNRS 6521, UFR Sciences et Techniques, Université de Bretagne Occidentale, 6, Av. Le Gorgeu, C.S. 93837, F-29238 Brest Cedex 3, France.
authors.forename: Erwann
authors.initials: E
authors.lastname: Picquet
authors.forename: Karine
authors.initials: K
authors.lastname: Le Ny
authors.forename: Pascal
authors.initials: P
authors.lastname: Delépine
authors.forename: Tristan
authors.initials: T
authors.lastname: Montier
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Yaouanc
authors.forename: Dominique
authors.initials: D
authors.lastname: Cartier
authors.forename: Hervé
authors.initials: H
authors.lastname: des Abbayes
authors.forename: Claude
authors.initials: C
authors.lastname: Férec
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Clément
mesh_terms: D000577:Amides / Q000737:chemistry*; D000818:Animals; D002412:Cations / Q000737:chemistry; D002460:Cell Line; D006224:Cricetinae; D004247:DNA / Q000008:administration & dosage* / Q000235:genetics; D018014:Gene Transfer Techniques / Q000295:instrumentation*; D017930:Genes, Reporter / Q000235:genetics; D005822:Genetic Vectors / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D063088:Phosphoramides; D010756:Phosphoric Acids / Q000737:chemistry*; D010766:Phosphorylation
chemical_list: D000577:Amides; D002412:Cations; D006146:Guanidines; D008055:Lipids; D063088:Phosphoramides; D010756:Phosphoric Acids; C005438:phosphoramide; D004247:DNA