title: Alternative Candida albicans lifestyles: growth on surfaces.
abstract: Candida albicans, an opportunistic fungal pathogen, causes a wide variety of human diseases such as oral thrush and disseminated candidiasis. Many aspects of C. albicans physiology have been studied during liquid growth, but in its natural environment, the gastrointestinal tract of a mammalian host, the organism associates with surfaces. Growth on a surface triggers several behaviors, such as biofilm formation, invasion, and thigmotropism, that are important for infection. Recent discoveries have identified factors that regulate these behaviors and revealed the importance of these behaviors for pathogenesis.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA. carol.kumamoto@tufts.edu
authors.forename: Carol A
authors.initials: CA
authors.lastname: Kumamoto
authors.forename: Marcelo D
authors.initials: MD
authors.lastname: Vinces
mesh_terms: D000328:Adult; D000818:Animals; D018441:Biofilms / Q000254:growth & development*; D002176:Candida albicans / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity*; D002177:Candidiasis / Q000382:microbiology / Q000473:pathology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D025301:Hyphae / Q000254:growth & development*; D007223:Infant; D007231:Infant, Newborn; D011817:Rabbits; D051381:Rats; D013499:Surface Properties
chemical_list: D005656:Fungal Proteins