title: Serial assessment of variability in heart rate in children with the Fontan circulation.
abstract: Autonomic nervous control of the heart can be studied by analysing variability in heart rate. Although earlier studies have shown reduced variability in patients with the Fontan circulation, we are not aware of any previous study examining longitudinal changes in such children. We have examined 13 patients who had undergone total cavopulmonary connection, and 37 healthy controls matched for age and gender. The examinations included complete echocardiography, and 24-hour ambulatory electrocardiogram for analysis of the parameters for variability in heart rate. After the Fontan procedure, three follow-up examinations were performed at a mean of 4.4 years, 5.6 and 7.2 years. Reduced variability was found in those with the Fontan circulation. A significant difference was found between patients and their controls with respect to high-frequency power at the second, p equal to 0.05, and third, p equal to 0.03, examination. The ratio of low-to-high-frequency components progressively increased in those with the Fontan circulation, a phenomenon that led to a significant difference, p equal to 0.03, at the third examination. Our study shows that, in patients with the Fontan circulation, routine ambulatory electrocardiographic monitoring including analysis of variability in heart rate, detects over time a progressive sympatovagal imbalance.
authors.affiliation: Department of Clinical Sciences, Section of Paediatric Cardiology, University Hospital, Umeå, Sweden. Annika.Rydberg@pediatri.umu.se
authors.forename: Annika
authors.initials: A
authors.lastname: Rydberg
authors.forename: Urban
authors.initials: U
authors.lastname: Wiklund
authors.forename: Peter
authors.initials: P
authors.lastname: Rask
authors.forename: Rolf
authors.initials: R
authors.lastname: Hörnsten
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001775:Blood Circulation / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D018729:Fontan Procedure; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D012016:Reference Values; D014463:Ultrasonography; D016276:Ventricular Function / Q000502:physiology