Solid-phase synthesis of 1,2-diheterocyclic-substituted (E)-olefins from a supported selenium resin.
A library of 1,2,3-triazoles, isoxazoles, 1,2,4-oxadiazoles, and isoxazoline-containing 1,2-di-heterocyclic-substituted compounds with three points of diversity linked by an E double bond were prepared. Key steps include a 1,3-dipolar cycloaddition and Porco's two-step, one-pot condensation and alpha-alkylation reaction of selenium resins.
Xu
Wei-Ming
WM
Department of Chemistry and Center of Analysis and Measurement, Zhejiang University, Hangzhou 310028, P. R. China.
Huang
Xian
X
Tang
E
E
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004345:Drug Industry / Q000379:methods; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry*; D012643:Selenium / Q000737:chemistry*
D000475:Alkenes; D006574:Heterocyclic Compounds, 2-Ring; D012117:Resins, Synthetic; D012643:Selenium