[The role of leukotriene D4 antagonist in allergic rhinitis with steroid resistance].
OBJECTIVE
To study the effect of using leukotriene D4 antagonist (LTRAs) and inhaled corticosteroid (ICS) to allergic rhinitis (AR), as well as the effect of leukotriene D4 antagonist on allergic rhinitis with steroid resistance.


METHODS
Several different inhaled corticosteroid were used to deal with allergic rhinitis and assess their effect by scores. The patients with steroid resistance were treated with montelukast sodium 10 mg/day for two weeks.


RESULTS
There is higher rate of steroid resistance among patients with both of kind symptoms of allergic rhinitis and asthma. Montelukast sodium can significantly alleviate the symptom of patients who suffer from allergic rhinitis with steroid resistance (P < 0.05). Cooperative utilization of mometasone furoate and montelukast sodium is more effective to alleviate allergic symptoms.


CONCLUSIONS
Leukotriene D4 antagonist can be an adjunct therapy of allergic rhinitis with steroid resistance. Cooperative utilization of leukotriene D4 antagonist and inhaled corticosteroid in allergic rhinitis can be considerable.
Qu
Shenhong
S
The Otorhinolaryngeal Hospital of the First Affiliated Hospital of Sun-Yat-Sen University, Guangzhou, 510080, China. qsh_ent@163.com
Li
Tianying
T
Chen
Yanqiu
Y
Lin
Zhibing
Z
Ou
Zhiying
Z
D000085:Acetates / Q000627:therapeutic use*; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003521:Cyclopropanes; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D013440:Sulfides
D000085:Acetates; D003521:Cyclopropanes; D005938:Glucocorticoids; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast