Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms.
A population-based case-control study of lymphomas in England collected height and weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls. Obesity, defined as a body mass index (BMI) over 30 kg m(-2) at five years before diagnosis,, was associated with an increased risk of NHL (OR = 1.5, 95% CI 1.1-2.1). The excess was most pronounced for diffuse large B-cell lymphoma (OR = 1.9, 95% CI 1.3-2.8). Genetic variants in the leptin (LEP 19G > A, LEP -2548G > A) and leptin receptor genes (LEPR 223Q > R), previously shown to modulate NHL risk, as well as a polymorphism in the energy regulatory gene adiponectin (APM1 276G>T), were investigated. Findings varied with leptin genotype, the risks being decreased with LEP 19AA (OR = 0.7, 95% CI 0.5-1.0) and increased with LEP -2548GA (OR = 1.3, 95% CI 1.0-1.7) and -2548AA (OR = 1.4, 95% CI 1.0-1.9), particularly for follicular lymphoma. These genetic findings, which were independent of BMI, were stronger for men than women.
Willett
E V
EV
Epidemiology and Genetics Unit, Department of Health Sciences, Seebohm Rowntree Building, University of York, UK. eleanor.willett@egu.york.ac.uk
Skibola
C F
CF
Adamson
P
P
Skibola
D R
DR
Morgan
G J
GJ
Smith
M T
MT
Roman
E
E
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D004734:Energy Metabolism; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D020738:Leptin / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics; D054411:Receptors, Leptin
D017931:DNA Primers; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin