Nonpeptidergic circuits feel your pain.
Pain consists of both a sensory component and an affective component. In this issue of Neuron, Braz and colleagues genetically targeted the transneuronal tract tracer wheat germ agglutinin (WGA) to nonpeptidergic nociceptive neurons. They found that these neurons give rise to a specialized multisynaptic circuit that links pain signals in the periphery to limbic/affective regions of the brain.
Zylka
Mark J
MJ
Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D051379:Mice; D009415:Nerve Net / Q000378:metabolism / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D014909:Wheat Germ Agglutinins / Q000378:metabolism
D014909:Wheat Germ Agglutinins