title: A neonatal form of Steinert's myotonic dystrophy in twins after in vitro fertilization.
abstract: OBJECTIVE
  To report a case of nonidentical twins affected with a congenital form of Steinert's myotonic dystrophy (DM1), conceived by IVF owing to parental sterility, in which the mother presented a paucisymptomatic form of DM1 which was diagnosed as a result of the condition inherited by the twins.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Neonatal intensive care unit of a tertiary hospital.
  
  
  METHODS
  Newborn twins affected with the congenital form of DM1 and a 35-year-old nulliparous mother.
  
  
  METHODS
  In vitro fertilization.
  
  
  METHODS
  Molecular study of the CTG triplet expansion related with DM1.
  
  
  RESULTS
  Molecular study evidenced a pathologic expansion in both twins as well as in their mother.
  
  
  CONCLUSIONS
  This case should serve as a reminder to practitioners that assisted reproductive techniques have opened the possibility that asymptomatic or paucisymptomatic carriers of a genetic syndrome can inadvertently conceive fetuses affected with more serious forms of the illness.
authors.affiliation: Department of Pediatrics, Hospital Donostia, San Sebastián, Spain. ngarbar@yahoo.com
authors.forename: Nagore
authors.initials: N
authors.lastname: García de Andoin
authors.forename: Juncal
authors.initials: J
authors.lastname: Echeverría
authors.forename: Ana M
authors.initials: AM
authors.lastname: Cobo
authors.forename: Angel
authors.initials: A
authors.lastname: Rey
authors.forename: Luis
authors.initials: L
authors.lastname: Paisán
authors.forename: Adolfo
authors.initials: A
authors.lastname: López de Munain
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009223:Myotonic Dystrophy / Q000175:diagnosis* / Q000235:genetics*; D010375:Pedigree; D011247:Pregnancy