title: Fermented soy product supplemented with isoflavones affected fat depots in juvenile rats.
abstract: OBJECTIVE
  This study investigated the effects of soy product fermented by Enterococcus faecium and Lactobacillus jugurti supplemented with isoflavones on adipose tissue, blood lipid, and glucose levels on juvenile rats.
  
  
  METHODS
  Rats were fed a cholesterol-enriched diet for 3 wk as a preliminary treatment to create hypercholesterolemia. They were then fed a chow diet (HC), a chow diet plus fermented soy product supplemented with isoflavones (HCFI), a chow diet plus placebo (HCP), or a chow diet plus placebo supplemented with isoflavones (HCPI), respectively, for an additional 3 wk.
  
  
  RESULTS
  The beneficial effects of fermented soy product supplemented with isoflavones on epididymal (EPI) and retroperitoneal (RET) fat pads was likely due to isoflavones because adipocyte circumference (micrometers) in the HC group was significantly larger (EPI: 105.66 +/- 13.36; RET: 134.95 +/- 25.40) than that in the HCFI group (EPI: 93.17 +/- 12.80; RET: 108.62 +/- 15.50) and HCPI group (EPI: 93.06 +/- 15.10; RET: 112.34 +/- 18.21). The probiotic micro-organism accentuated the antilipogenic effect of isoflavones on RET (HCFI: 108.62 +/- 15.50 micrometers versus HCPI: 112.34 +/- 18.21 micrometers). Moreover, the fermented product increased glucose concentration similar to that in the chow group but did not change blood lipids.
  
  
  CONCLUSIONS
  This product may offer new approaches to obesity prevention.
authors.affiliation: Departamento de Educação Física e Motricidade Humana, Centro de Ciências Biológicas e da Saúde, Universidade Federal de São Carlos, São Paulo, Brazil. mamanzoni@hotmail.com
authors.forename: Marla S J
authors.initials: MS
authors.lastname: Manzoni
authors.forename: Elizeu A
authors.initials: EA
authors.lastname: Rossi
authors.forename: Iracilda Z
authors.initials: IZ
authors.lastname: Carlos
authors.forename: Regina C
authors.initials: RC
authors.lastname: Vendramini
authors.forename: Ana C G O
authors.initials: AC
authors.lastname: Duarte
authors.forename: Ana R
authors.initials: AR
authors.lastname: Dâmaso
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D000273:Adipose Tissue / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D048429:Cell Size; D016984:Enterococcus faecium / Q000378:metabolism; D005285:Fermentation; D006937:Hypercholesterolemia; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology*; D007778:Lactobacillus / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000517:prevention & control*; D019936:Probiotics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max
chemical_list: D001786:Blood Glucose; D007529:Isoflavones; D008055:Lipids