title: [Effects of Chansu injection on transplanting-tumor models S180 in mice and human colon cancer HT-29 in nude mice].
abstract: OBJECTIVE
  To study the antitumor effects of Chansu injection on transplanting- tumor of S(180 ) in mice and human colon cancer HT-29 in nude mice.
  
  
  METHODS
  Using transplanting- tumor models of S(180 ) in mice and human colon cancer HT-29 in nude mice,the tumor inhibitive ratio(IR) of Chansu injection was determined and apoptosis was microscopically observed.
  
  
  RESULTS
  Compared with tumor-negative control groups, IR at different dosage of Chansu in models of S(180) and HT-29 was 19.1% - 38.2% and 9.5% - 15.8% respectively,there was a dose-dependent relationship in models of S ( 180) (P< 0.05) and HT- 29 (P> 0.05). The tumor growth was markedly inhibited by cyclophosphamide (CTX) in model of S( 180) with IR of 70.7% and in model of HT-29 with IR of 67.1%, compared with control groups, both P< 0.01; apoptosis induced by CTX was markedly observed by in microscope examination. No significant side effects were shown in the study group.
  
  
  CONCLUSIONS
  Chansu injection can significantly inhibit tumor growth in model of S(180), but not in model of HT- 29. Different type of tumor has different drug-sensitivity.
authors.affiliation: Department of General Surgery, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou 510130, China. huayang@yahoo.com.cn
authors.forename: Zhen-huai
authors.initials: ZH
authors.lastname: Yang
authors.forename: Yong-ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Jie-wen
authors.initials: JW
authors.lastname: Guo
authors.forename: Jing-qiang
authors.initials: JQ
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Guan-ning
authors.initials: GN
authors.lastname: Li
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D019073:HT29 Cells; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D012510:Sarcoma 180 / Q000188:drug therapy*; D023041:Xenograft Model Antitumor Assays
chemical_list: D002018:Bufanolides; D004365:Drugs, Chinese Herbal; C095591:chan su