title: [Study of the association between human leukocyte antigens and Jorge Lobo's disease].
abstract: Jorge Lobo's disease is a cutaneous/subcutaneous mycosis with a chronic course, caused by the fungus Lacazia loboi. Considering its epidemiology and the few studies on immunological aspects of this disease, the objective of the present study was to investigate a possible association between HLA class II specificities in 21 Jorge Lobo's disease patients, by comparing them with healthy individual of the same ethnic group. HLA typing was performed using PCR-SSP method. The result did not show any association between HLA antigens and Jorge Lobo's disease. Although not statistically significant, a decreased frequency of HLA-DR7 was observed in the patients compared to the controls (0% x 18%). This suggests a negative association (protective) between HLA-DR7 and Jorge Lobo's disease. Further studies, however, are needed for a better understanding of the susceptibility and/or protection mechanisms involved.
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP. immunologia@ilsl.br
authors.forename: Elaine Valim Camarinha
authors.initials: EV
authors.lastname: Marcos
authors.forename: Fabiana Covolo de
authors.initials: FC
authors.lastname: Souza
authors.forename: Elza Araújo
authors.initials: EA
authors.lastname: Torres
authors.forename: José Roberto Pereira
authors.initials: JR
authors.lastname: Lauris
authors.forename: Diltor Vladimir de Araújo
authors.initials: DV
authors.lastname: Opromolla
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003881:Dermatomycoses / Q000276:immunology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: D000949:Histocompatibility Antigens Class II