The Gail model predicts breast cancer in women with suspicious radiographic lesions.
BACKGROUND
We sought to evaluate whether a woman's 5-year Gail risk adds to the predictive value of the Breast Imaging Reporting and Data System (BI-RADS) classification for the detection of breast cancer.


METHODS
We performed a retrospective review of the BI-RADS classifications and pathology results for all image-guided needle breast biopsy examinations over a 3-year period at our institution. The 5-year Gail risk was calculated for eligible patients. Chi-square analysis was used to compare rates of malignancy based on Gail and BI-RADS scores.


RESULTS
A total of 632 image-guided needle biopsy examinations were performed in 609 women. A total of 414 women had suspicious (BI-RADS 4) lesions and underwent 424 biopsy examinations. For this subset, women with a Gail risk of less than 1.7% had 21% malignant results, whereas those with a Gail risk of 1.7% or greater had 42% malignant results (relative risk, 1.94; 95% confidence interval, 1.45-2.66).


CONCLUSIONS
The Gail model can stratify further the risk for breast cancer in women with suspicious breast imaging reports.
Weik
Jennifer L
JL
Department of Surgery, Loma Linda University Medical Center, 11175 Campus St., Suite 21111, Loma Linda, CA 92354, USA.
Lum
Sharon S
SS
Esquivel
Pamela A
PA
Tully
Richard J
RJ
Bae
Won C
WC
Petersen
Floyd F
FF
Jaque
Jenny M
JM
Reeves
Mark E
ME
Garberoglio
Carlos A
CA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D016217:Ultrasonography, Mammary