title: Radiofrequency ablation in surgery.
abstract: Recently, hyperthermia has been employed clinically as one of a variety of multimodal therapies for cancer. Hyperthermia has been applied locally, regionally, and systemically to various tumors. Local or regional hyperthermia has the advantage that a localized tumor can be heated to temperatures higher than 420 C, the maximum for total-body hyperthermia. There is mounting evidence to support a hypothesis that cancer cells are more selectively sensitive to heat than are normal cells, due to the poor blood supply of neoplastic tissue and the decreased vasodilatation capacity of the neovascular bed.
authors.affiliation: Department of Surgery, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, British Columbia.
authors.forename: E J
authors.initials: EJ
authors.lastname: Patterson
authors.forename: C H
authors.initials: CH
authors.lastname: Scudamore
authors.forename: A K
authors.initials: AK
authors.lastname: Buczkowski
authors.forename: D A
authors.initials: DA
authors.lastname: Owen
authors.forename: A G
authors.initials: AG
authors.lastname: Nagy