Interrogating rodents regarding their object and spatial memory.
Today, neuroscientists have access to a host of advanced techniques -- ranging from targeted genetic interventions to brain imaging -- that are rapidly providing new insights. Ultimately, however, memory must be inferred from its behavioral read-out. Thus, to fully utilize the advanced technologies available today, we must select the most appropriate behavioral procedures from those currently available, or else devise novel behavioral techniques to meet a specific demand. If we merely use standard tests of memory in a non-optimal way, we risk collecting incomplete information and reaching erroneous conclusions. Relevant to these issues, there have been substantial developments in the methods used to evaluate two of the most frequently studied forms of memory in the rodent -- recognition memory and spatial memory.
Clark
Robert E
RE
Department of Psychiatry, 0603 University of California San Diego and Veterans Affairs Medical Center, San Diego, La Jolla, CA 92093, USA. reclark@ucsd.edu
Martin
Stephen J
SJ
D000818:Animals; D006801:Humans; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D012377:Rodentia / Q000502:physiology*