GLUT4 trafficking in a test tube.
Insulin regulates glucose transport in muscle and fat cells by stimulating the translocation of GLUT4 from intracellular vesicles to the plasma membrane. In this issue of Cell Metabolism, Holman and colleagues reconstitute this process in vitro, providing a system that promises new breakthroughs in our understanding of this important metabolic process.
Ramm
Georg
G
Garvan Institute of Medical Research, Darlinghust, NSW, Australia.
James
David E
DE
D002462:Cell Membrane / Q000378:metabolism*; D005089:Exocytosis; D051275:Glucose Transporter Type 4; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D008081:Liposomes; D008561:Membrane Fusion; D008954:Models, Biological; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D022161:Transport Vesicles / Q000378:metabolism*
D051275:Glucose Transporter Type 4; D007328:Insulin; D008081:Liposomes; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins