title: Pulmonary non-caseating granuloma in Waldenström macroglobulinemia.
abstract: Lung involvement is rare in Waldenström macroglobulinemia (WM). We encountered a male patient with WM who complained of breathlessness. Chest X-ray revealed diffuse infiltrative shadow throughout the both lungs. Transbronchial biopsy showed infiltration of atypical plasmacytoid lymphocytes and non-caseating granuloma. We treated the patients with fludarabine phosphate, and both his symptom and X-ray findings were then improved. To our knowledge, this is the first case showing non-caseating granuloma with lung involvement of WM. We discuss a mechanism of non-caseating granuloma formation in this case.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan. f.ryuki@is.icc.u-tokai.ac.jp
authors.forename: Ryuki
authors.initials: R
authors.lastname: Fukuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawada
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yanagi
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kojima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Urano
authors.forename: Ito
authors.initials: I
authors.lastname: Chie
authors.forename: Makoto
authors.initials: M
authors.lastname: Onizuka
authors.forename: Satomi
authors.initials: S
authors.lastname: Fukagawa
authors.forename: Masako
authors.initials: M
authors.lastname: Shimada
authors.forename: Rikio
authors.initials: R
authors.lastname: Suzuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takagi
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Hotta
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016726:Plasma Cell Granuloma, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011859:Radiography; D016896:Treatment Outcome; D001084:Vidarabine Phosphate / Q000031:analogs & derivatives / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D001084:Vidarabine Phosphate; C042382:fludarabine phosphate