title: Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma.
abstract: We have studied the role of systemic oxidative stress for survival of patients with head and neck squamous cell carcinomas (HNSCC). Patients with lowest plasma total GSH levels had the lowest 36 months survival. In patients with post-radiotherapy concentrations of plasma total GSH less than median value, about 73% died during the 36 months follow-up compared to about 21% of patients with GSH values above median. Systemic oxidative stress as assessed by low GSH in post-radiotherapy plasma is associated to outcome in HNSCC patients.
authors.affiliation: Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, Blindern N-0316, Oslo, Norway.
authors.forename: Siv Kjølsrud
authors.initials: SK
authors.lastname: Bøhn
authors.forename: Sigbjørn
authors.initials: S
authors.lastname: Smeland
authors.forename: Amrit Kaur
authors.initials: AK
authors.lastname: Sakhi
authors.forename: Magne
authors.initials: M
authors.lastname: Thoresen
authors.forename: Kjell Magne
authors.initials: KM
authors.lastname: Russnes
authors.forename: Johan
authors.initials: J
authors.lastname: Tausjø
authors.forename: Arne
authors.initials: A
authors.lastname: Svilaas
authors.forename: Tone
authors.initials: T
authors.lastname: Svilaas
authors.forename: Rune
authors.initials: R
authors.lastname: Blomhoff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005978:Glutathione / Q000097:blood*; D006258:Head and Neck Neoplasms / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005978:Glutathione