title: Evaluation of toxicities induced by chemotherapy in breast cancer patients.
abstract: The study includes the breast cancer female patients who had received chemotherapy (CMF, tamoxifen) and the newly diagnosed breast cancer patients, who had not received any chemotherapy. The patients who had received six cycles of CMF had shown low RBC, WBC and platelet count, elevated levels of SGPT, alkaline phosphatase and lactate dehydrogenase as compared to newly diagnosed breast cancer patients. The RBC count is increased in patients who had received CMF and tamoxifen as compared to the patients received only CMF, the alkaline phosphatase level is also declined in patients who had received CMF and tamoxifen as compared to the patients received CMF only.
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Lubna
authors.initials: L
authors.lastname: Mehreen
authors.forename: Aziza
authors.initials: A
authors.lastname: Khanam
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity*; D001792:Blood Platelets / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity; D015331:Cohort Studies; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity; D008875:Middle Aged; D010154:Pakistan; D010976:Platelet Count; D013629:Tamoxifen / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity*; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate