title: The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population.
abstract: Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction.
authors.affiliation: Immunology & Immunogenetics, Palacky University & Faculty Hospital Olomouc, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Cermakova
authors.forename: J
authors.initials: J
authors.lastname: Petrkova
authors.forename: A
authors.initials: A
authors.lastname: Arakelyan
authors.forename: J
authors.initials: J
authors.lastname: Drabek
authors.forename: F
authors.initials: F
authors.lastname: Mrazek
authors.forename: J
authors.initials: J
authors.lastname: Lukl
authors.forename: M
authors.initials: M
authors.lastname: Petrek
mesh_terms: D000483:Alleles; D018932:Chemokine CCL2 / Q000235:genetics* / Q000276:immunology; D003327:Coronary Disease / Q000235:genetics / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000276:immunology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000276:immunology; D011237:Predictive Value of Tests
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2