title: Grade 3 ischemia on admission and absence of prior beta-blockade predict failure of ST resolution following thrombolysis for anterior myocardial infarction.
abstract: BACKGROUND
  ST segment resolution (STR) is a strong predictor of outcome following thrombolysis. If failure of STR could be predicted on admission, better selection of treatment may be possible. Among patients given reperfusion, those with terminal QRS distortion (grade 3 ischemia) have larger infarcts, but the mechanism underlying this association is unclear. Whether grade 3 ischemia on admission can predict STR is unknown.
  
  
  METHODS
  We studied 180 consecutive patients given thrombolysis for a first anterior acute myocardial infarction (AMI). Multiple variables available on admission were analyzed as predictors of STR at 1, 2, and 24 h and as predictors of the need for rescue percutaneous coronary intervention (PCI).
  
  
  RESULTS
  Multivariate predictors of failure of STR were: for 1 h: extent of ST elevation (OR: 1.09 [1.01-1.18]); for 2 h: no previous use of beta-blockers (OR: 4.71 [1.56-13.98]) and grade 3 ischemia (OR: 6.77 [3.27-13.95]); for 24 h: previous use of aspirin (OR: 6.70 [1.31-34.01]) and grade 3 ischemia (OR: 29.44 [7.30-118.1]). Grade 3 ischemia had a strong positive predictive value for failure of STR at 1 and 2 h and was the strongest predictor of the need for rescue PCI.
  
  
  CONCLUSIONS
  Grade 3 ischemia on admission is the strongest independent predictor of failure to achieve myocardial reperfusion after thrombolysis. This association may underlie the larger infarcts associated with grade 3 ischemia. Other predictors of reperfusion failure are the extent of ST segment elevation, prior use of aspirin and no prior use of beta-blockers.
authors.affiliation: Department of Cardiology, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84101, Israel.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Buber
authors.forename: Harel
authors.initials: H
authors.lastname: Gilutz
authors.forename: Yochai
authors.initials: Y
authors.lastname: Birnbaum
authors.forename: Michael
authors.initials: M
authors.lastname: Friger
authors.forename: Reuben
authors.initials: R
authors.lastname: Ilia
authors.forename: Doron
authors.initials: D
authors.lastname: Zahger
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy; D016017:Odds Ratio; D010343:Patient Admission; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists