Extracorporeal membrane oxygenation with lepirudin anticoagulation for Wegener's granulomatosis with heparin-induced thrombocytopenia.
Venovenous extracorporeal membrane oxygenation with lepirudin anticoagulation was successfully used for a complicated case of Wegener's granulomatosis and heparin-induced thrombocytopenia. Interestingly, a linear correlation was found between activated partial thromboplastin time and activated clotting time during lepirudin anticoagulation.
Balasubramanian
Sendhil K
SK
Department of ECMO and Cardiac Surgery, Glenfield Hospital, Groby Road, Leicester, United Kingdom.
Tiruvoipati
Ravindranath
R
Chatterjee
Shimonti
S
Sosnowski
Andrew
A
Firmin
Richard K
RK
D000925:Anticoagulants / Q000627:therapeutic use*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000473:pathology; D006493:Heparin; D006629:Hirudins; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011994:Recombinant Proteins / Q000627:therapeutic use; D012128:Respiratory Distress Syndrome / Q000628:therapy; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; C083544:lepirudin