Convergent evolution as a mechanism for pathogenic adaptation.
The survival of human pathogens depends on their ability to modulate defence pathways in human host cells. This was thought to be attained mainly by pathogen specific "virulence factors". However, pathogens are increasingly being discovered that use distant homologs of the human regulatory proteins as virulence factors. We analyzed several cases of this approach, with a particular focus on virulence proteases. The analysis reveals clear cases of bacterial proteases mimicking the specificity of their human counterparts, such as strong similarities in their active and/or binding sites. With more sensitive tools for distant homology recognition, we could expect to discover many more such cases.
Sikora
Sergey
S
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Strongin
Alex
A
Godzik
Adam
A
D000222:Adaptation, Physiological; D000595:Amino Acid Sequence; D001419:Bacteria / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology; D005075:Biological Evolution; D008958:Models, Molecular; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism; D013381:Subtilisins / Q000737:chemistry / Q000502:physiology; D037521:Virulence Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D001426:Bacterial Proteins; D037521:Virulence Factors; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; D013381:Subtilisins; C471626:mycosin-1, Mycobacterium tuberculosis; C021433:IgA-specific serine endopeptidase