Antioxidant activity of new ruthenium compounds.
Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl2(nic)4] where nic is 3-pyridinecarboxylic acid and trans-[RuCl2(i-nic)4] where i-nic is 4-pyridinecarboxylic acid by (i) evaluation of total antioxidant potential (TRAP); (ii) prevention of DNA damage induced by hydrogen peroxide using the alkaline comet assay; and (iii) the prevention of lipid peroxidation and cell death induced by iron in liver slices. Our results suggest that nic has stronger antioxidant potential when compared to the i-nic. Higher doses (above 200 microM) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1-10 microM).
Paula
Marcos Marques da Silva
MM
Laboratório de Síntese de Complexos Multifuncionais, Universidade do Extremo Sul Catarinense (UNESC), Criciúma, SC, Brazil.
Pich
Claus Tröger
CT
Petronilho
Fabrícia
F
Drei
Lilian Batista
LB
Rudnicki
Martina
M
de Oliveira
Marcos Roberto
MR
Moreira
José Cláudio Fonseca
JC
Henriques
João Antônio Pegas
JA
Franco
César Vittorio
CV
Dal Pizzol
Felipe
F
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D020552:Comet Assay; D004249:DNA Damage; D007539:Isonicotinic Acids / Q000494:pharmacology; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D009525:Niacin / Q000494:pharmacology; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D012428:Ruthenium / Q000494:pharmacology*; D017975:Ruthenium Compounds / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000975:Antioxidants; D007539:Isonicotinic Acids; D017975:Ruthenium Compounds; D009525:Niacin; D012428:Ruthenium