Concentration of prothrombin fragment 1 + 2 (f1 + 2) in patients with liver cirrhosis and chronic hepatitis C infection.
The aim of this study was to assess the serum concentration of F1 + 2 in patients with liver cirrhosis developed during HCV infection and in patients with chronic hepatitis C infection. The study group consisted of 52 patients hospitalised at the Department of Infectious Diseases of Medical University of Lublin, Poland. Among them, 18 patients (8 men and 10 women), aged 19-59 years, had a stable liver cirrhosis and 34 patients (21 men and 13 women), aged 20-41 years, were diagnosed with chronic hepatitis C infection. The control group consisted of 25 healthy individuals (13 men and 12 women), aged 19-60 years. The serum concentration of F1 + 2 was determined by the immunoenzymatic assay Enzygnost F1 + 2 micro. There were no statistically significant differences observed in serum concentration of F1 + 2, both in patients with stable cirrhosis and with CHC, compared to controls. However, in 16.7% of patients with cirrhosis and in 35.3% of patients with CHC elevated serum levels of F1 + 2 were observed.
Fota-Markowska
Hanna
H
Department of Infectious Diseases, Skubiszewski Medical University of Lublin.
Modrzewska
Roma
R
Krzowska-Firych
Joanna
J
Lis-Tønder
Joanna
J
Borowicz
Irena
I
D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D011516:Prothrombin
D010446:Peptide Fragments; C045879:prothrombin fragment 1.2; D011516:Prothrombin