Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.
Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.
Hirota
Kiichi
K
Department of Anesthesia, Kyoto University Hospital, Kyoto University, Kyoto 606-8507, Japan.
Semenza
Gregg L
GL
D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000201:enzymology* / Q000378:metabolism; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000502:physiology; D011393:Procollagen-Proline Dioxygenase / Q000737:chemistry* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D051793:Hypoxia-Inducible Factor 1; D006899:Mixed Function Oxygenases; C058291:aspartic acid 2-oxoglutarate-dependent dioxygenase; D011393:Procollagen-Proline Dioxygenase