Genetic diversity of anaplasma species major surface proteins and implications for anaplasmosis serodiagnosis and vaccine development.
The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity of Anaplasma major surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity of Anaplasma spp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.
de la Fuente
José
J
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA. jose_delafuente@yahoo.com
Lew
Ala
A
Lutz
Hans
H
Meli
Marina L
ML
Hofmann-Lehmann
Regina
R
Shkap
Varda
V
Molad
Thea
T
Mangold
Atilio J
AJ
Almazán
Consuelo
C
Naranjo
Victoria
V
Gortázar
Christian
C
Torina
Alessandra
A
Caracappa
Santo
S
García-Pérez
Ana L
AL
Barral
Marta
M
Oporto
Beatriz
B
Ceci
Luigi
L
Carelli
Grazia
G
Blouin
Edmour F
EF
Kocan
Katherine M
KM
D042322:Anaplasma marginale / Q000145:classification / Q000235:genetics* / Q000276:immunology; D000712:Anaplasmosis / Q000175:diagnosis* / Q000517:prevention & control*; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis*; D001428:Bacterial Vaccines; D002417:Cattle; D010802:Phylogeny; D012698:Serologic Tests / Q000662:veterinary; D020080:Tandem Repeat Sequences; D014611:Vaccination / Q000662:veterinary*
D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines