title: [Clinical and virological studies of nosocomial conjunctivitis infection caused by adenovirus type 37 variant].
abstract: OBJECTIVE
  To study the clinical features and virological analysis of the nosocomial adenoviral conjunctivitis cases occurring in the ophthalmology ward of Fukushima Medical University Hospital.
  
  
  METHODS
  We studied the symptoms and clinical course of 61 patients who had adenoviral conjunctivitis caused by nosocomial infections in our hospital. We attempted to detect the adenovirus antigen, analyze the viral DNA, and isolate the virus from conjunctival swabs.
  
  
  RESULTS
  The clinical symptoms of adenoviral conjunctivitis were mainly conjunctival hyperemia, discharge and conjunctival follicles. Adenoviral conjunctivitis patients who had undergone ophthalmic surgery had conjunctivitis in the operated eye. The sensitivity of Adeno-check was 78.9% in the in-patients. Adenovirus type 37 variant was detected by molecular analysis and viral isolation.
  
  
  CONCLUSIONS
  Adenoviral conjunctivitis can often lead to outbreaks of nosocomial infection in the ophthalmic ward and sometimes requires makes necessary restriction of hospitalization and closing of the ward. Therefore, patients need to be observed carefully. The virological analysis of specimens from conjunctival swabs detected pathogens and provided useful information concerning adenoviral conjunctivitis.
authors.affiliation: Department of Ophthalmology, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
authors.forename: Hisatoshi
authors.initials: H
authors.lastname: Kaneko
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iida
authors.forename: Rika
authors.initials: R
authors.lastname: Miura
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakajima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ishiko
authors.forename: Toshihide
authors.initials: T
authors.lastname: Ariga
authors.forename: Koki
authors.initials: K
authors.lastname: Aoki
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suzutani
mesh_terms: D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000328:Adult; D003231:Conjunctivitis / Q000821:virology*; D003428:Cross Infection / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male