Pulmonary hyalinizing granuloma. Bilateral pulmonary nodules associated with chronic idiopathic thrombocytopenic purpura.
We report a case of a 30-year-old female who had been treated periodically with steroids for idiopathic thrombocytopenic purpura ITP over the last 10 years. Recently, during the course of investigation, she was found to have incidental asymptomatic multiple pulmonary nodules on chest CT. Following a needle biopsy to exclude malignancy, 2 nodules were excised and were histologically confirmed as pulmonary hyalinizing granuloma PHG. The remaining 2 nodules regressed on increasing her dose of steroids. The case is discussed with emphasis on the histological and radiological differential diagnosis, in addition to including ITP among the spectrum of immunologic conditions associated with PHG.
Satti
Mohamed B
MB
Department of Pathology, King Abdul-Aziz Medical City, Jeddah, Jeddah 21423, Kingdom of Saudi Arabia. sattimb@ngha.med.sa
Batouk
Abdelnasir A
AA
Abdelaziz
Muntasir M
MM
Ahmad
Mohamed F
MF
Abdelaal
Mohamed A
MA
D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D015769:Granuloma, Respiratory Tract / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D007150:Immunohistochemistry; D011239:Prednisolone / Q000627:therapeutic use*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D035583:Rare Diseases; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D011239:Prednisolone