Perivascular infiltrate of memory lymphocytes and mature dendritic cells in MG thymomas.
In thymomas associated with myasthenia gravis (MG), the authors found that perivascular infiltrates of memory lymphocytes and mature dendritic cells (DCs) were more frequent in patients with early improvement after thymectomy than in patients without response to thymectomy. Although these findings may be limited to particular types of thymoma, thymectomy may interrupt the recruitment of mature DCs in thymus and export of activated T cells to extra-thymic tissues, thereby improving the disease.
Nagane
Y
Y
Department of Neurology, Iwate Medical University, 19-1 Uchimaru, Morioka, 020-8505, Japan.
Utsugisawa
K
K
Akutsu
H
H
Sato
Y
Y
Terayama
Y
Y
D000368:Aged; D015551:Autoimmunity / Q000276:immunology; D001808:Blood Vessels / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D013950:Thymus Gland / Q000098:blood supply / Q000276:immunology / Q000503:physiopathology
D011950:Receptors, Cholinergic