Coregistration of dynamic contrast enhanced MRI and broadband diffuse optical spectroscopy for characterizing breast cancer.
A hand-held scanning probe based on broadband Diffuse Optical Spectroscopy (DOS) was used in combination with dynamic contrast enhanced MRI (DCE-MRI) to quantitatively characterize locally-advanced breast cancers in six patients. Measurements were performed sequentially using external fiducial markers for co-registration. Tumor patterns were categorized according to MRI morphological data, and 3D DCE-MRI slices were converted into a volumetric matrix with isotropic voxels to generate views that coincided with the DOS scanning plane. Tumor volume and depth at each DOS measurement site were determined, and a tissue optical index (TOI) that reflects both angiogenic and stromal characteristics was derived from broadband DOS data. In all six cases, optical scans showed significant TOI contrast corresponding to MRI morphological information. Sharp TOI peaks were recovered for well-circumscribed masses. A reduction in TOI was found inside a tumor with a necrotic center. A broadened peak was observed for a diffuse tumor pattern, and an inflammatory septal case provided two TOI peaks that correlated qualitatively with MRI enhancement. These results provide qualitative confirmation of the common signal origin and complementary information content that can be achieved by combining optical and MR imaging for breast cancer detection and clinical management.
Hsiang
David
D
Chao Comprehensive Cancer Center, Division of Oncological Surgery, University of California, Irvine Medical Center, 101 The City Drive, Orange, CA 92868, USA. dhsiang@uci.edu
Shah
Natasha
N
Yu
Hon
H
Su
Min-Ying
MY
Cerussi
Albert
A
Butler
John
J
Baick
Choong
C
Mehta
Rita
R
Nalcioglu
Orhan
O
Tromberg
Bruce
B
D000328:Adult; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D006801:Humans; D007834:Lasers; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012680:Sensitivity and Specificity
D003287:Contrast Media