Computed tomography and sonographic findings of hepatic metastases from gastrointestinal stromal tumors after chemotherapy.
OBJECTIVE
The purpose of this study was to evaluate the computed tomography (CT) and sonographic findings in patients with hepatic metastases from gastrointestinal stromal tumors (GISTs) after STI-571 treatment.


METHODS
Computed tomography and sonographic findings of 8 lesions in 6 patients with hepatic metastases from GISTs that were treated with STI-571 were retrospectively analyzed. The change in size, attenuation, and echogenicity of the hepatic metastases from GISTs after STI-571 treatment was evaluated.


RESULTS
After treatment with STI-571, the hepatic metastases were decreased in size and the attenuation of the hepatic metastases was homogeneously hypodense on CT. Sonography revealed the hepatic metastases to be centrally cystic with a thin wall (n = 4) or predominantly solid (n = 4) after STI-571 treatment. On color Doppler sonography, no blood flow was identified within the solid portion of the mass.


CONCLUSIONS
After treatment with STI-571, although the hepatic metastases from GISTs exhibit a cystic appearance on CT, they may appear as solid masses on sonography.
Yang
Dal Mo
DM
Department of Radiology, Gachon Medical School, Gil Medical Center, Incheon, South Korea. dmyang@ghil.com
Kim
Hana
H
Kang
Jee Hee
JH
Park
Chul Hi
CH
Kim
Hyung Sik
HS
Shin
Dong Bok
DB
D000328:Adult; D000368:Aged; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate