title: Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico.
abstract: Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.
authors.affiliation: Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 degrees Piso, Centro Médico Nacional Siglo XXI, IMSS, Col. Doctores, CP 06725, México DF. fercalber1@hotmail.com
authors.forename: Claudia
authors.initials: C
authors.lastname: Velázquez
authors.forename: Fernando
authors.initials: F
authors.lastname: Calzada
authors.forename: Javier
authors.initials: J
authors.lastname: Torres
authors.forename: Felipe
authors.initials: F
authors.lastname: González
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ceballos
mesh_terms: D000818:Animals; D002772:Cholera Toxin / Q000494:pharmacology; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008800:Mexico; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; D002772:Cholera Toxin