Increased levels of CSF phosphorylated tau in apolipoprotein E epsilon4 carriers with mild cognitive impairment.
We investigated the correlation between the apolipoprotein E varepsilon4 allele (apoE epsilon4) carrier status, a major risk factor of Alzheimer's disease (AD), and levels of tau protein phosphorylated at threonine 231 (P-tau(231P)) in cerebrospinal fluid (CSF) in predementia and clinical stages of AD and healthy controls (HC). Thirty-one subjects with mild cognitive impairment (MCI) who had converted to AD during follow-up were included, as well as 71 AD patients, and 29 HC subjects. In MCI, but not in AD and HC, CSF P-tau(231P) levels were significantly higher in apoE epsilon4 carriers compared to non-carriers (p<0.001). Controlling for disease duration, the apoE epsilon4 effect on P-tau(231P) remained significant. Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects.
Buerger
Katharina
K
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany. katharina.buerger@med.uni-muenchen.de
Teipel
Stefan J
SJ
Zinkowski
Raymond
R
Sunderland
Trey
T
Andreasen
Niels
N
Blennow
Kaj
K
Ewers
Michael
M
DeBernardis
John
J
Shen
Yong
Y
Kerkman
Daniel
D
Du
Yansheng
Y
Hampel
Harald
H
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D006580:Genetic Carrier Screening / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013548:Sweden / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D016875:tau Proteins
D001057:Apolipoproteins E; C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D016875:tau Proteins