A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction.
A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.
Bressy
Cyril
C
Davenport Laboratories, Chemistry Department, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
Alberico
Dino
D
Lautens
Mark
M
D000478:Alkylation; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D007211:Indoles; D008024:Ligands; D009942:Organometallic Compounds; D010165:Palladium