title: Yersinia pestis is viable with endotoxin composed of only lipid A.
abstract: Lipopolysaccharide (LPS) is the major outer membrane component of gram-negative bacteria. The minimal LPS structure for viability of Escherichia coli and Salmonella enterica serovar Typhimurium is lipid A glycosylated with 3-deoxy-D-manno-octulosonic acid (Kdo) residues. Here we show that another member of the Enterobacteriaceae, Yersinia pestis, can survive without Kdo in its LPS.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, BBRB Box 19, 1530 3rd Avenue South, Birmingham, Alabama 35294-2170, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Tan
authors.forename: Creg
authors.initials: C
authors.lastname: Darby
mesh_terms: D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism*; D008050:Lipid A / Q000032:analysis / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship; D015010:Yersinia pestis / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology
chemical_list: D001427:Bacterial Toxins; D008050:Lipid A; D008070:Lipopolysaccharides