Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma.
We have studied the role of systemic oxidative stress for survival of patients with head and neck squamous cell carcinomas (HNSCC). Patients with lowest plasma total GSH levels had the lowest 36 months survival. In patients with post-radiotherapy concentrations of plasma total GSH less than median value, about 73% died during the 36 months follow-up compared to about 21% of patients with GSH values above median. Systemic oxidative stress as assessed by low GSH in post-radiotherapy plasma is associated to outcome in HNSCC patients.
Bøhn
Siv Kjølsrud
SK
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1046, Blindern N-0316, Oslo, Norway.
Smeland
Sigbjørn
S
Sakhi
Amrit Kaur
AK
Thoresen
Magne
M
Russnes
Kjell Magne
KM
Tausjø
Johan
J
Svilaas
Arne
A
Svilaas
Tone
T
Blomhoff
Rune
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005978:Glutathione / Q000097:blood*; D006258:Head and Neck Neoplasms / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005978:Glutathione