title: Synergy between sequence and size in large-scale genomics.
abstract: Until recently the study of individual DNA sequences and of total DNA content (the C-value) sat at opposite ends of the spectrum in genome biology. For gene sequencers, the vast stretches of non-coding DNA found in eukaryotic genomes were largely considered to be an annoyance, whereas genome-size researchers attributed little relevance to specific nucleotide sequences. However, the dawn of comprehensive genome sequencing has allowed a new synergy between these fields, with sequence data providing novel insights into genome-size evolution, and with genome-size data being of both practical and theoretical significance for large-scale sequence analysis. In combination, these formerly disconnected disciplines are poised to deliver a greatly improved understanding of genome structure and evolution.
authors.affiliation: Department of Integrative Biology, University of Guelph, Ontario N1G 2W1, Canada. rgregory@genomesize.com
authors.forename: T Ryan
authors.initials: TR
authors.lastname: Gregory
mesh_terms: D001483:Base Sequence / Q000235:genetics*; D019143:Evolution, Molecular; D016678:Genome / Q000235:genetics*; D040481:Genome Components / Q000235:genetics*; D023281:Genomics / Q000379:methods / Q000639:trends*; D017421:Sequence Analysis / Q000379:methods