Spectral assignments for the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4'-imidazoline]-2',5'-dione and its synthetic intermediates.
The 1H and 13C NMR chemical shifts of the aldose reductase inhibitor 4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro[chroman-4,4'-imidazoline]-2',5'-dione, methylsorbinil, and its seven synthetic intermediates, have been completely assigned on the basis of DEPT, COSY, g-HSQC and g-HMBC. All C--F coupling constants from one-bond to four-bond in the 13C NMR spectra and H--F and H--H coupling constants from three-bond to four-bond in 1H spectra were obtained.
Wang
Mingan
M
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198-6025, USA.
Mishra
Manoj K
MK
Zhu
Wenjun
W
Kador
Peter F
PF
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
C508038:4(S)-2,3-dihydro-6-fluoro-2(R)-methylspiro(chroman-4,4'-imidazoline)-2',5'-dione; D002839:Chromans; D004791:Enzyme Inhibitors; D007093:Imidazoles; D000449:Aldehyde Reductase