Discordance between functional magnetic resonance imaging during silent speech tasks and intraoperative speech arrest.
OBJECTIVE
The goal of this study was to investigate discordance between the location of speech arrest during awake cortical mapping, a common intraoperative indicator of hemispheric dominance, and silent speech functional magnetic resonance (fMR) imaging maps of frontal language function.


METHODS
Twenty-one cases were reviewed retrospectively. Images of silent speech fMR imaging activation were coregistered to anatomical MR images obtained for neuronavigation. These were compared with the intraoperative cortical photographs and the behavioral results of electrocorticography during awake craniotomy. An fMR imaging control study of three healthy volunteers was then conducted to characterize the differences between silent and vocalized speech fMR imaging protocols used for neurosurgical planning.


CONCLUSIONS
Results of fMR imaging showed consistent and predominant activation of the inferior frontal gyrus (IFG) during silent speech tasks. During intraoperative mapping, however, 16 patients arrested in the precentral gyrus (PRG), well posterior to the fMR imaging activity. Of those 16, 14 arrested only in the PRG and not in the IFG as silent speech fMR imaging predicted. The control fMR imaging study showed that vocalized speech fMR imaging shifts the location of the fMR imaging prediction to include the motor strip and may be more appropriate for neurosurgical planning.
Petrovich
Nicole
N
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Holodny
Andrei I
AI
Tabar
Viviane
V
Correa
Denise D
DD
Hirsch
Joy
J
Gutin
Philip H
PH
Brennan
Cameron W
CW
D001931:Brain Mapping; D003071:Cognition; D003399:Craniotomy; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015203:Reproducibility of Results; D013060:Speech / Q000502:physiology*; D013064:Speech Disorders / Q000503:physiopathology*