title: Relationship of virulence factor expression to evolved virulence in mouse-passaged Cryptococcus neoformans lines.
abstract: Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of virulence remain to be discovered.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. mcclella@aecom.yu.edu
authors.forename: Erin E
authors.initials: EE
authors.lastname: McClelland
authors.forename: Wesley T
authors.initials: WT
authors.lastname: Perrine
authors.forename: Wayne K
authors.initials: WK
authors.lastname: Potts
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
mesh_terms: D000818:Animals; D003455:Cryptococcus neoformans / Q000254:growth & development* / Q000472:pathogenicity*; D051379:Mice; D012692:Serial Passage; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D037521:Virulence Factors