[Effects of ulinastatin on erythrocyte lipid peroxidation in patients undergoing open heart surgery].
OBJECTIVE
To investigate the effects of ulinastatin on erythrocyte lipid peroxidation in patients undergoing open heart surgery.


METHODS
Twenty adult patients with rheumatic heart disease undergoing elective value replacement were divided randomly into 2 groups of 10 patients each: a control group (group C) and an ulinastatin group (group W). The patients were premedicated with intramuscular morphine 0.08 mg/kg and scopolamine 0.06 mg/kg. Anesthesia was induced with midazolam 0.1 mg/kg, fentanyl 5 microg/kg and vecuronium 0.1 mg/kg. After the tracheal intubation, the patients were mechanically ventilated. Anesthesia was maintained with midazolam, fentanyl and isoflurane. Blood samples were taken from radial artery before the operation (T1), 30 min after the initiation of CPB (T2), at the end of the CPB (T3), 30 min after the aorta declamping (T4) and 24 h after the operation (T5) for the determination of plasma and erythrocyte MDA (P-MDA and E-MDA) and erythrocyte SOD (E-SOD).


RESULTS
The levels of P-MDA and E-MDA increased significantly after the initiation of CPB and the level of E-SOD was higher than the baseline level at T2, and then decreased from T3 to T5 in group C (P <0.001). The levels of P-MDA and E-MDA didn't increased until T4 (P <0.001) and returned to the baseline level at T5 in group W. The levels of P-MDA and E-MDA were significantly higher in group C than those in group W and the level of E-SOD was markedly lower than that in group W (P <0.05).


CONCLUSIONS
Ulinastatin can alleviate erythrocyte lipid peroxidation in patients undergoing open heart surgery.
Shen
Jin-Mei
JM
Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Li
Li
L
He
Xiao-Jing
XJ
D000328:Adult; D002315:Cardiopulmonary Bypass; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000627:therapeutic use*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000378:metabolism / Q000601:surgery*
D006023:Glycoproteins; C028665:urinastatin