Intracerebral hemorrhage: pathophysiology and therapy.
Spontaneous intracerebral hemorrhage, from several sources, causes instantaneous mass effect, disruption of surrounding brain, and often an early neurological death. If the patient survives the initial event, the hematoma can lead to secondary brain injury, neurological deficits, and, occasionally, delayed fatality. The mechanisms that trigger pathophysiological changes in and around the hematoma are becoming better understood, offering new therapeutic opportunities.
Xi
Guohua
G
Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-0532, USA. guohuaxi@umich.edu
Fewel
Matthew E
ME
Hua
Ya
Y
Thompson
B Gregory
BG
Hoff
Julian T
JT
Keep
Richard F
RF
D001777:Blood Coagulation / Q000502:physiology; D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology; D006454:Hemoglobins / Q000502:physiology; D006801:Humans
D006454:Hemoglobins