Insulin-like growth factor and interleukin-1beta levels and subsequent fetal size in response to chronic Porphyromonas gingivalis exposure in the pregnant rabbit.
OBJECTIVE
The purpose of this study was to describe maternal insulin-like growth factor, interleukin-1beta, and fetal size in a rabbit model of Porphyromonas gingivalis exposure.


METHODS
With the use of a previously described model, 8 New Zealand White rabbits were exposed to either P gingivalis or media during pregnancy and killed at term. Kit and placenta weight were compared between groups. Doe serum insulin-like growth factor system protein and interleukin-1beta levels were compared by analysis of variance for repeated measures; a probability value of <.05 was considered to be significant.


RESULTS
No significant differences in kit and placental weights between exposed and unexposed groups were observed. Insulin-like growth factor system proteins increased significantly as pregnancy progressed, but there were no significant differences in insulin-like growth factor system proteins or interleukin-1beta between exposed and unexposed does.


CONCLUSIONS
Chronic P gingivalis exposure does not disrupt insulin-like growth factor system proteins or systemic inflammation and does not impair fetal growth in the pregnant rabbit. Gestational age changes in doe insulin-like growth factor system proteins occur, and the timing of exposure to oral pathogens may influence fetal growth.
Boggess
Kim A
KA
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill School of Medicine, 27599, USA. kboggess@med.unc.edu
Price
Wayne A
WA
Preisser
John S
JS
Moise
Kenneth J
KJ
Offenbacher
Steven
S
D000818:Animals; D016866:Bacteroidaceae Infections / Q000503:physiopathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D020567:Fetal Weight; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007375:Interleukin-1 / Q000097:blood*; D010510:Periodontal Diseases / Q000097:blood / Q000503:physiopathology*; D016966:Porphyromonas gingivalis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000503:physiopathology*; D011817:Rabbits
D007375:Interleukin-1; D007334:Insulin-Like Growth Factor I