Induction of apoptosis in colorectal cancer cells by peroxisome proliferators-activated receptor gamma activation up-regulating PTEN and inhibiting PI3K activity.
Chen
Wei-chang
WC
Department of Gastroenterology, First Affiliated Hospital, Suzhou Univercity, Suzhou 215006, China. weichangchen@126.com
Lin
Mao-song
MS
Bai
Xia
X
D017209:Apoptosis; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D019073:HT29 Cells; D006801:Humans; D047495:PPAR gamma / Q000235:genetics / Q000502:physiology*; D051059:PTEN Phosphohydrolase; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis*; D015230:Prostaglandin D2 / Q000031:analogs & derivatives / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000032:analysis; D011518:Proto-Oncogene Proteins / Q000032:analysis; D051057:Proto-Oncogene Proteins c-akt; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology; D025521:Tumor Suppressor Proteins / Q000032:analysis*; D015854:Up-Regulation
C477819:15-deoxyprostaglandin J2; D047495:PPAR gamma; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D045162:Thiazolidinediones; D025521:Tumor Suppressor Proteins; D000077154:Rosiglitazone; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D015230:Prostaglandin D2