[The proper use of carbapenem examined by Monte Carlo simulation].
Monte Carlo simulation was employed for this comparative study to determine the optimal Carbapenem and its dosing strategy to cure the infections by Escherichia coli and Pseudomonas aeruginosa and to consider how the difference of each Carbapenems in dosing regimens and antibiotic activity influenced to maximize % T > MIC. This result revealed that it was important to increase a dose and a number of doses a day, in addition to great antibiotic activity for maximizing % T > MIC.
Mikamo
Hiroshige
H
Division of Anaerobe Research, Life Science Research Center, Gifu University.
Totsuka
Kyouichi
K
D015780:Carbapenems / Q000008:administration & dosage*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D009010:Monte Carlo Method; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa
D015780:Carbapenems