Effect of nandrolone decanonate on paraoxonase activity in hemodialysis patients.
OBJECTIVE
This study was designed to determine the effect of nandrolone decanonate (ND) on HDL-C, apolipoproteins and paraoxonase (PON) activity in stable hemodialysis patients.


METHODS
64 hemodialysis patients were treated with ND at a dose of 100 mg/I.M./week for 4 months. HDL-C, Apo-AI, Apo B, concentrations and PON activity were measured before and after 2 and 4 months of treatment as well as 2 months after withdrawing the treatment.


RESULTS
After 4 months of treatment, an elevation in the serum levels of Apo B (P<0.0001) and a marked decrease in the concentration of HDL-C (P<0.0001), Apo-AI (P<0.0001) and PON activity (P<0.0001) were found. A significant correlation between PON and both Apo-AI (r=0.270, P<0.04) and HDL-C (r=0.455, P<0.0001) and also between HDL-C and Apo-AI (r=0.305, P<0.02) were found.


CONCLUSIONS
Results revealed the adverse effects of ND on apolipoprotein levels in our study population. It is possible that ND reduces PON activity mostly by reducing both the HDL-C and Apo-AI levels.
Ghorbanihaghjo
Amir
A
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz- Iran. ghorbaniamir@hotmail.com
Argani
Hassan
H
Rahbaninoubar
Mohammad
M
Rashtchizadeh
Nadereh
N
D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood / Q000187:drug effects*; D008076:Cholesterol, HDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D006435:Renal Dialysis / Q000379:methods*; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D009277:Nandrolone; D043303:Aryldialkylphosphatase; D000077603:Nandrolone Decanoate