title: Molecular evidence of recurrent histoplasmosis with 9-year latency in a patient with Addison's disease.
abstract: We present a case of fatal histoplasmosis in a patient with Addison's disease and long-term use of corticosteroid. The patient acquired Histoplasma capsulatum in China and initially presented with a laryngeal mass. He developed fulminant pneumonia and respiratory failure 9 years later. Nucleotide sequences of internal transcribed spacer regions of rRNA genes of the H. capsulatum isolate recovered from biopsied lung tissue and of the extracted fungal DNA from the laryngeal lesion were identical, indicating the recurrent nature of infection.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei.
authors.forename: Tai-Chung
authors.initials: TC
authors.lastname: Tseng
authors.forename: Shwu-Jen
authors.initials: SJ
authors.lastname: Liaw
authors.forename: Cheng-Hsiang
authors.initials: CH
authors.lastname: Hsiao
authors.forename: Cheng-Yi
authors.initials: CY
authors.lastname: Wang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Lee
authors.forename: Tien-Shang
authors.initials: TS
authors.lastname: Huang
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
mesh_terms: D000224:Addison Disease / Q000150:complications*; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D021903:DNA, Ribosomal Spacer / Q000032:analysis; D006658:Histoplasma / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D012340:RNA, Ribosomal, 5.8S / Q000235:genetics; D012008:Recurrence; D017422:Sequence Analysis, DNA; D013997:Time Factors
chemical_list: D021903:DNA, Ribosomal Spacer; D012340:RNA, Ribosomal, 5.8S