Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia.
In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.
Tissing
Wim J E
WJ
Lauten
Melchior
M
Meijerink
Jules P P
JP
den Boer
Monique L
ML
Koper
Jan Willem
JW
Sonneveld
Peter
P
Pieters
Rob
R
D002648:Child; D015331:Cohort Studies; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000096:biosynthesis; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D011239:Prednisolone / Q000627:therapeutic use*; D020033:Protein Isoforms / Q000096:biosynthesis; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis* / Q000235:genetics
D005938:Glucocorticoids; D020033:Protein Isoforms; D011965:Receptors, Glucocorticoid; D011239:Prednisolone