title: WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature.
abstract: Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions--including cell death--in adjacent cells, and raise the possibility that they do so in many different cellular contexts.
authors.affiliation: Division of Developmental Biology, The Children's Hospital Research Foundation and Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45229, USA.
authors.forename: Ivan B
authors.initials: IB
authors.lastname: Lobov
authors.forename: Sujata
authors.initials: S
authors.lastname: Rao
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Carroll
authors.forename: Jefferson E
authors.initials: JE
authors.lastname: Vallance
authors.forename: Masataka
authors.initials: M
authors.lastname: Ito
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Ondr
authors.forename: Savita
authors.initials: S
authors.lastname: Kurup
authors.forename: Donald A
authors.initials: DA
authors.lastname: Glass
authors.forename: Millan S
authors.initials: MS
authors.lastname: Patel
authors.forename: Weiguo
authors.initials: W
authors.lastname: Shu
authors.forename: Edward E
authors.initials: EE
authors.lastname: Morrisey
authors.forename: Andrew P
authors.initials: AP
authors.lastname: McMahon
authors.forename: Gerard
authors.initials: G
authors.lastname: Karsenty
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lang
mesh_terms: D000818:Animals; D017209:Apoptosis; D042783:Endothelial Cells / Q000166:cytology* / Q000378:metabolism*; D005123:Eye / Q000098:blood supply*; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008024:Ligands; D008264:Macrophages / Q000166:cytology / Q000378:metabolism* / Q000502:physiology / Q000637:transplantation; D051379:Mice; D008822:Mice, Transgenic; D018919:Neovascularization, Physiologic; D019899:Paracrine Communication; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins
chemical_list: D006023:Glycoproteins; D008024:Ligands; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; C095937:Wnt7b protein, mouse