Two new benzoquinone derivatives and two new bisorbicillinoids were isolated from a marine-derived fungus Penicillium terrestre.
Four new compounds were isolated from a marine-derived fungus Penicillium terrestre, namely 2-(2', 3'-dihydrosorbyl)-3,6-dimethyl-5-hydroxy-1,4-benzoquinone (1), 3-acetonyl-2,6-dimethyl-5-hydroxy-1,4-benzoquinone (2), dihydrobisvertinolone (3), tetrahydrobisvertinolone (4). Their structures were established on the basis of spectroscopic methods. The absolute configurations of 3 and 4 were determined by their CD spectra. Their cytotoxic effects on P388 and A-549 cell lines were preliminarily examined by the MTT method.
Liu
Weizhong
W
Key laboratory of Marine Drugs, Chinese Ministry of Education, PR China.
Gu
Qianqun
Q
Zhu
Weiming
W
Cui
Chengbin
C
Fan
Guotao
G
D000818:Animals; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D007941:Leukemia P388; D015394:Molecular Structure; D010407:Penicillium; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D016227:Benzoquinones; D003512:Cyclohexanones