Cardiovascular disease in systemic lupus erythematosus: has the time for action come?
OBJECTIVE
The recognition that inflammation is a hallmark of atherosclerotic disease has led to a series of studies reporting accelerated atherogenesis in chronic inflammatory diseases. Indeed, systemic lupus erythematosus is associated with an increased incidence of cardiovascular disease and the etiology thereof deserves closer attention.


RESULTS
The association between systemic lupus erythematosus and accelerated atherosclerosis has recently been confirmed by surrogate-marker studies for cardiovascular disease in patients with systemic lupus erythematosus. Since the propensity towards cardiovascular disease cannot solely be explained by classical risk factors, disease-specific pathways have been put forward as additional risk factors.


CONCLUSIONS
In the present review, we will discuss several of these factors as well as their potential impact for future prevention strategies in systemic lupus erythematosus.
van Leuven
Sander I
SI
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Kastelein
John J P
JJ
Hayden
Michael R
MR
d'Cruz
David
D
Hughes
Graham R
GR
Stroes
Erik S
ES
D050197:Atherosclerosis / Q000175:diagnosis* / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology / Q000401:mortality