title: High doses of atorvastatin (Sortis) modify the secretory process in the exocrine portion of the pancreas.
abstract: Changes were observed in the ultrastructure of the pancreatic acinar cells in rats after administration of atorvastatin (Sortis) in the therapeutic and ten times larger dose for the period of 6 weeks. It was found that atorvastatin given to rats in the therapeutic dose (80 mg/day) stimulated the secretion in pancreocytes, whereas the ten times higher dose of atorvastatin distorts the complicated process of the release of the secretion from the cell.
authors.affiliation: Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Czerny
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Romanowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Kifer-Wysocka
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Matysiak
authors.forename: Teresa
authors.initials: T
authors.lastname: Masłyk
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D002118:Calcium / Q000378:metabolism; D006538:Heptanoic Acids / Q000633:toxicity*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000633:toxicity*; D046790:Pancreas, Exocrine / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D011758:Pyrroles / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D002118:Calcium