Histomorphometry of nuclei of proximal convoluted tubules epithelium of kidney of experimental animals after Cladribine (2-CdA) administration.
The area of the section of nuclei of the epithelium cells lining the proximal convoluted tubules of the kidney of white Wistar rats was examined. The animals were given Cladribine (2-CdA) subcutaneously at the dosages of 0.07 mg/kg b.w./24 h for seven days and 0.1 mg/kg b.w./24 h for 6 days in three courses with 5 weeks' break between each. The animals were killed in each instance, 24 hours after the last dose of the drug and 4 weeks after the last dose. The mean area of the section of the cell's nuclei was measured in projection microscope. Results of the examination were counted statistically. In experimental groups I and III the surface areas of the proximal tubules epithelium nuclei cross-sections are smaller than in the control grous. In the experimental groups II and IV the surface areas of the proximal tubules epithelium nuclei cross-sections are bigger than in the control group.
Lis-Sochocka
Marta
M
Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.
Czerny
Krystyna
K
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects* / Q000473:pathology; D048429:Cell Size; D017338:Cladribine / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007279:Injections, Subcutaneous; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D017338:Cladribine