Histological examination of the kidney after experimental administration of MK-801 and dexamethasone.
The aim of the research was histological assessment of the influence of MK-801 (NMDA receptor antagonist) and dexamethasone on the kidney. The experiment was carried out on adult Albino-Swiss mouse males. MK-801 was administered in the dose of 0.3 mg/kg/24 h for 8 days, dexamethasone--in the toxic dose of 120 mg/kg/24 h. Kidney slices stained with hematoxylin and eosin and with PAS method were examined with light microscope. The performed experiments revealed that MK-801 causes morphological changes in the shape of slight narrowing of the urinary spaces in renal corpuscles and narrowing of the lumen of the proximal convoluted tubules and dexamethasone administered in toxic doses causes dilatation of these spaces with kidney's hyperemia. MK-801 intensifies morphological changes of the kidney induced by toxic doses of dexamethasone.
Sekita-Krzak
Joanna
J
Department of Histology and Embryology with the Laboratory for Experimental Cytology, Skubiszewski Medical University of Lublin.
Visconti
Józef
J
Wójtowicz
Zbigniew
Z
Zebrowska-Lupina
Iwona
I
Ossowska
Grazyna
G
Klenk-Majewska
Bozena
B
D000818:Animals; D003907:Dexamethasone / Q000633:toxicity*; D016291:Dizocilpine Maleate / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D051379:Mice
D016291:Dizocilpine Maleate; D003907:Dexamethasone