Prevention and treatment of osteoporosis in chronically ill children.
Osteoporosis secondary to chronic disease in children has emerged as a major health issue. As the severity of a child's illness increases, so too does the number of factors affecting their bone health. Determinants of bone health in children include level of mobility, exposure to osteotoxic medication, nutritional status, calcium and vitamin D intake, chronic inflammation and pubertal development.
Munns
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CF
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, Australia. craigm2@chw.edu.au
Cowell
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CT
D000293:Adolescent; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D002648:Child; D002908:Chronic Disease / Q000534:rehabilitation*; D004164:Diphosphonates / Q000627:therapeutic use; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007103:Immobilization / Q000502:physiology; D010020:Osteonecrosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy*; D011628:Puberty, Delayed / Q000150:complications / Q000503:physiopathology; D014808:Vitamin D Deficiency / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control
D004164:Diphosphonates; D005938:Glucocorticoids