Anti-inflammatory activity of Lippia dulcis.
Lippia dulcis hexane and ethanol extracts were tested for its anti-inflammatory activity in several animal models. Hexane extract showed to be inactive, but the ethanol extract at doses of 400 mg/kg produced significant inhibition of carrageenan-induced paw oedema and reduced the weight of cotton pellet-induced granuloma, moreover, the topical application of 0.5 mg/ear of this extract inhibited the edema induced with TPA by 49.13%, an effect which is of less intensity than that produced by indomethacine at the same dose.
Pérez
S
S
Depto Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, A.P. 23-181, México D.F., Mexico. msperez@correo.xoc.uam.mx
Meckes
M
M
Pérez
C
C
Susunaga
A
A
Zavala
M A
MA
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006801:Humans; D032411:Lippia; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts