title: Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.
abstract: We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma). Our results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. This represents the first characterization of a naturally occurring, highly metastatic tumor with biologically significant mutations of PTEN in the C-terminal domain.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Dickerson
authors.forename: R
authors.initials: R
authors.lastname: Thomas
authors.forename: S P
authors.initials: SP
authors.lastname: Fosmire
authors.forename: A R
authors.initials: AR
authors.lastname: Lamerato-Kozicki
authors.forename: S R
authors.initials: SR
authors.lastname: Bianco
authors.forename: J W
authors.initials: JW
authors.lastname: Wojcieszyn
authors.forename: M
authors.initials: M
authors.lastname: Breen
authors.forename: S C
authors.initials: SC
authors.lastname: Helfand
authors.forename: J F
authors.initials: JF
authors.lastname: Modiano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006394:Hemangiosarcoma / Q000235:genetics* / Q000662:veterinary*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D051059:PTEN Phosphohydrolase / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D051059:PTEN Phosphohydrolase