Chromosome 11-q24 region in Tourette syndrome: association and linkage disequilibrium study in the French Canadian population.
Previous studies have found association and linkage between Tourette syndrome (TS) and markers at the 11q24 region, mainly with markers D11S1377 and D11S933. In order to determine if these positive findings could be replicated in our sample, we undertook a family-based association study in 199 French Canadian TS nuclear families. We genotyped 572 individuals from 174 complete and 25 incomplete TS trios. TDT analysis failed to detect an association between TS and six markers from 11q24. Furthermore, no haplotype combining alleles from D11S1377, D11S933, or any of the other four markers was associated with the disorder. Linkage disequilibrium analysis showed evidence of historical recombination between every contiguous pair of markers, indicating that these genetic variants are probably in equilibrium in the French Canadian population. Further analysis in additional families, with different methodologies (linkage and association) will be required in order to determine if the 11q24 region harbors a susceptibility locus for TS. If it does, this defect may not be frequent in the French Canadian population due to locus heterogeneity.
Díaz-Anzaldúa
Adriana
A
Instituto Nacional de Psiquiatría Ramón de la Fuente, Mexico City, Mexico.
Rivière
Jean-Baptiste
JB
Dubé
Marie-Pierre
MP
Joober
Ridha
R
Saint-Onge
Judith
J
Dion
Yves
Y
Lespérance
Paul
P
Richer
Francois
F
Chouinard
Sylvain
S
Rouleau
Guy Armand
GA
D000293:Adolescent; D002170:Canada; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D011792:Quebec; D005879:Tourette Syndrome / Q000235:genetics*
D005819:Genetic Markers