[Skin cells as steroid target; the steroid action in some skin diseases and wound healing].
The paper is concerned with contemporary concepts on the role of androgens, estrogens, progesterone, mineralcorticosteroids, glucocorticoids and vitamin D3 and their signal transduction pathways in skin physiology, pathology and wound healing. The new therapeutic strategies based on mechanisms of steroid action have been presented. The classic, genomic pathway based on nuclear receptor activation is a well documented fact but less is known about indirect, nongenomic steroid effects. Steroids induced effects depend on their concentration, type of target cells and the receptors as well as accompanying side effects.
Krzysiek-Maczka
Gracjana
G
Zakład Biologii Komórki, Wydział Biotechnologii, Uniwersytetu Jagiellofiskiego Kierownik Zakładu. gracjana@awe.mol.uj.edu.pl
D000728:Androgens / Q000494:pharmacology; D002762:Cholecalciferol / Q000494:pharmacology; D020405:Dermis / Q000187:drug effects; D004817:Epidermis / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D008901:Mineralocorticoids / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D012871:Skin Diseases / Q000188:drug therapy*; D013256:Steroids / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D000728:Androgens; D004967:Estrogens; D005938:Glucocorticoids; D008901:Mineralocorticoids; D013256:Steroids; D002762:Cholecalciferol; D011374:Progesterone