title: Biological activity of Spatoglossum asperum: a brown alga.
abstract: Chloroform and methanol fractions of an ethanol extract of Spatoglossum asperum showed antifungal activity against the highly destructive plant pathogen, Macrophomina phaseolina while the n-hexane fraction showed activity against Rhizoctonia solani and Fusarium solani. n-Hexane and methanol fractions also showed nematicidal activity against the plant parasitic nematode, Meloidogyne javanica. Column chromatography of the ethanol extract of seaweed yielded oily fractions named SA-I to SA-VI. GC-MS data of these oily fractions showed the presence of various fatty acid esters. Some of these oily fractions exhibited strong antifungal and nematicidal activities. Oily fractions of S. asperum also showed hypolipidaemic activity in normal, triton-induced and high fat diet-induced hyperlipidaemic rats without producing any ill effect on cardiac and liver enzymes.
authors.affiliation: Department of Food Science and Technology, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Jehan
authors.initials: J
authors.lastname: Ara
authors.forename: Viqar
authors.initials: V
authors.lastname: Sultana
authors.forename: Rashida
authors.initials: R
authors.lastname: Qasim
authors.forename: Syed
authors.initials: S
authors.lastname: Ehteshamul-Haque
authors.forename: Viqar Uddin
authors.initials: VU
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004041:Dietary Fats; D008401:Gas Chromatography-Mass Spectrometry; D006949:Hyperlipidemias / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D000459:Phaeophyceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D014431:Tylenchoidea / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D000969:Antinematodal Agents; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010936:Plant Extracts