Association of reduced carbon monoxide diffusing capacity with moderate or severe left ventricular diastolic dysfunction in obese persons.
OBJECTIVE
To determine the association of reduced diffusing capacity of the lung for carbon monoxide (D(LCO)) with moderate or severe left ventricular diastolic dysfunction (LVDD) in obese persons.


METHODS
We investigated the association of D(LCO) with LVDD in 105 patients with a mean +/- SD body mass index of 49 +/- 5 kg/m2. An abnormal D(LCO) was < 80%. LVDD was investigated by Doppler and by tissue Doppler echocardiography. The Doppler echocardiographic data were analyzed blindly without knowledge of the clinical characteristics or whether the D(LCO) was normal or abnormal.


METHODS
A university hospital.


METHODS
The 105 patients included 19 men and 86 women (mean age, 45 +/- 9 years).


RESULTS
An abnormal D(LCO) was present in 62 of 105 patients (59%). Moderate or severe LVDD was present in 35 of 105 patients (33%). Moderate or severe LVDD was present in 25 of 62 patients (40%) with an abnormal D(LCO) and in 10 of 43 patients (23%) with a normal D(LCO) (p < 0.05).


CONCLUSIONS
Obese patients with a decreased D(LCO) have an increased prevalence of moderate or severe LVDD.
Ravipati
Gautham
G
Pulmonary and Critical Care, Department of Medicine, Westechester Medical Center, New York Medical College, Valhalla 10595, USA.
Aronow
Wilbert S
WS
Sidana
Jasdeep
J
Maguire
George P
GP
McClung
John A
JA
Belkin
Robert N
RN
Lehrman
Stuart G
SG
D000328:Adult; D002248:Carbon Monoxide / Q000502:physiology*; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications*; D015995:Prevalence; D011653:Pulmonary Diffusing Capacity / Q000502:physiology*; D016037:Single-Blind Method; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology*
D002248:Carbon Monoxide