Nephrotic syndrome (NS) and pregnancy in rat--evaluation of kidney in electron microscopy.
The purpose of this study was the histological evaluation of kidneys on the ultrastructural level. In the experiment there were used pregnant female rats in which gestation coexisted with adriamycin-induced NS. Results showed numerous focal changes in kidney glomerules and tubules which were the evidence of increased protein loss and filtration barrier damage as the main cause of increased permeability for proteins.
Pedrycz
Agnieszka
A
Department of Histology and Embryology, Lab of Experimental Cytology, Skubiszewski Medical University of Lublin.
Wieczorski
Marcin
M
Czerny
Krystyna
K
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D051381:Rats; D012016:Reference Values; D014617:Vacuoles / Q000187:drug effects / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin