title: Clostridium botulinum: an increasing complication of heroin misuse.
abstract: Wound botulism is a rare infectious disease due to neurotoxin release from the anaerobic, spore-forming bacterium Clostridium botulinum that is becoming an ever more frequent complication of parenteral drug abuse in the Western world. Before the year 2000, no such cases had been reported in the UK and Ireland, but since then the number of proven and suspected cases of wound botulism occurring in parenteral drug users has increased markedly. The diagnosis is often difficult, based on a high degree of clinical suspicion and if not considered in the initial differential diagnosis, then considerable delays in treatment may result. This is the case report of a male heroin user who presented three times to an Emergency Department in the UK before a diagnosis of wound botulism was made and treatment commenced. It is important that emergency clinicians are aware of the possibility of wound botulism in parenteral drug users that present with unusual neurological or respiratory symptomatology.
authors.affiliation: Department of Emergency Medicine, Leeds General Infirmary, Leeds, UK. Jamie.Julie@totalise.co.uk
authors.forename: Jamie G
authors.initials: JG
authors.lastname: Cooper
authors.forename: Cord E
authors.initials: CE
authors.lastname: Spilke
authors.forename: Miles
authors.initials: M
authors.lastname: Denton
authors.forename: Stuart
authors.initials: S
authors.lastname: Jamieson
mesh_terms: D000328:Adult; D001904:Botulinum Antitoxin / Q000627:therapeutic use; D001906:Botulism / Q000139:chemically induced / Q000188:drug therapy / Q000635:transmission*; D003014:Clostridium botulinum / Q000187:drug effects / Q000302:isolation & purification*; D003932:Heroin / Q000138:chemical synthesis / Q000633:toxicity*; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008297:Male; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000382:microbiology*
chemical_list: D001904:Botulinum Antitoxin; D003932:Heroin