title: Synergistic potential of ceftazidime plus amikacin or levofloxacin against Pseudomonas aeruginosa as determined using a checkerboard and a disk diffusion technique.
abstract: The synergistic potential of ceftazidime plus amikacin or levofloxacin was assessed against 61 Pseudomonas aeruginosa isolates with variable susceptibility patterns to the 3 antibiotics. A checkerboard broth method and a disk diffusion method were used and compared. The latter, also easy to perform as a triple-disk assay, could be a helpful laboratory screening tool for drug synergism to drive possible combination treatments.
authors.affiliation: Institute of Microbiology and Biomedical Sciences, Marche Polytechnic University Medical School, 60131 Ancona, Italy.
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Montanari
authors.forename: Laura
authors.initials: L
authors.lastname: Piccoli
authors.forename: Marina
authors.initials: M
authors.lastname: Mingoia
authors.forename: Federico
authors.initials: F
authors.lastname: Marchetti
authors.forename: Pietro Emanuele
authors.initials: PE
authors.lastname: Varaldo
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005779:Immunodiffusion / Q000379:methods; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D000583:Amikacin; D002442:Ceftazidime; D015242:Ofloxacin