Genes differentially expressed in responsive and refractory acute leukemia.
DNA microarray in 22 patients with acute leukemia revealed genes which were differentially expressed. Ribosomal protein SA (RPSA), minichromosome maintenance deficient 2 (MCM2) and heterogeneous nuclear ribonucleoprotein A1 (HNRPA1) were significantly upregulated (p<0.05, t test) in refractory patients, suggesting that they may play a role in refractoriness in acute leukemia and could be biomarkers of prognosis.
Wei
Qing
Q
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China.
Li
Yao
Y
Chen
Li
L
Zhang
Liying
L
He
Xianmin
X
Fu
Xuping
X
Ying
Kang
K
Huang
Jianfeng
J
Chen
Qin
Q
Xie
Yi
Y
Mao
Yumin
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins / Q000096:biosynthesis; D005260:Female; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000096:biosynthesis; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064111:Minichromosome Maintenance Complex Component 2; D009687:Nuclear Proteins / Q000096:biosynthesis; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D017474:Receptors, Laminin / Q000096:biosynthesis; D012269:Ribosomal Proteins / Q000096:biosynthesis; D015854:Up-Regulation
D015415:Biomarkers; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D009687:Nuclear Proteins; C510624:RPSA protein, human; D017474:Receptors, Laminin; D012269:Ribosomal Proteins; C000619656:hnRNPA1 protein, human; C084859:MCM2 protein, human; D064111:Minichromosome Maintenance Complex Component 2