title: The determinants of bone mineral density in Chinese men--results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men.
abstract: Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65-92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.
authors.affiliation: Hong Kong Orthopaedic and Osteoporosis Center for Treatment and Research, Unit 1301, Hing Wai Building, 36 Queen's Road Central, Hong Kong, China. edithmclau@netvigator.com
authors.forename: E M C
authors.initials: EM
authors.lastname: Lau
authors.forename: P C
authors.initials: PC
authors.lastname: Leung
authors.forename: T
authors.initials: T
authors.lastname: Kwok
authors.forename: J
authors.initials: J
authors.lastname: Woo
authors.forename: H
authors.initials: H
authors.lastname: Lynn
authors.forename: E
authors.initials: E
authors.lastname: Orwoll
authors.forename: S
authors.initials: S
authors.lastname: Cummings
authors.forename: J
authors.initials: J
authors.lastname: Cauley
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D017677:Age Distribution; D000368:Aged; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D015331:Cohort Studies; D006615:Hip / Q000503:physiopathology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008019:Life Style; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005082:Physical Exertion / Q000502:physiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013131:Spine / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones