title: Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats.
abstract: Trigonella foenum-graecum, commonly known as fenugreek, is a traditional medicinal plant of the Leguminoseae family in India. The antioxidant effect of fenugreek leaves was evaluated in the streptozotocin-induced diabetic rat model. The antioxidant effect was evaluated by estimating thiobarbituric acid-reactive substances and reduced glutathione and measuring the activities of catalase and superoxide dismutase in liver, heart, and kidney in diabetic rats. Fenugreek leaf powder supplementation significantly lowered lipid peroxidation and significantly increased the antioxidant system in diabetic rats. The effect at a dose of 1 g/kg of body weight of fenugreek leaf powder was similar to that of glibenclamide. Insulin restores all the parameters to near normal values. Thus, fenugreek leaf powder reduces oxidative stress in experimental diabetes.
authors.affiliation: Department of Biochemistry, Annamalai University, Annamalainagar, Tamil Nadu, India. psmprince@rediffmail.com
authors.forename: B
authors.initials: B
authors.lastname: Annida
authors.forename: P
authors.initials: P
authors.lastname: Stanely Mainzen Prince
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology; D002374:Catalase / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism / Q000628:therapy*; D019587:Dietary Supplements; D005260:Female; D005978:Glutathione / Q000032:analysis / Q000737:chemistry; D005905:Glyburide / Q000008:administration & dosage; D007668:Kidney / Q000201:enzymology; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000032:analysis; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D029910:Trigonella / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D005905:Glyburide