C3'-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: synthesis and SAR studies.
The synthesis of a series of C3'-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure-activity relationship for this series as agonists of group II metabotropic glutamate receptors is reported.
González
Rosario
R
Lilly, Alcobendas, Madrid, Spain. gonzalez_rosario@lilly.com
Collado
Iván
I
de Uralde
Beatriz López
BL
Marcos
Alicia
A
Martín-Cabrejas
Luisa M
LM
Pedregal
Concepción
C
Blanco-Urgoiti
Jaime
J
Pérez-Castells
Javier
J
Fernández
M Alejandro
MA
Andis
Sherri L
SL
Johnson
Bryan G
BG
Wright
Rebecca A
RA
Schoepp
Darryle D
DD
Monn
James A
JA
D018360:Crystallography, X-Ray; D003500:Cyclization; D005998:Glycine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3; D005998:Glycine