title: Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
abstract: The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed current clinical classification systems in Crohn's disease, ulcerative colitis and indeterminate colitis, and provided recommendations for clinical classification in practice. Progress with respect to integrating serological and genetic markers has been examined in detail, and the implications are discussed. While an integrated system is not proposed for clinical use at present, the introduction of a widely acceptable clinical subclassification is strongly advocated, which would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.
authors.affiliation: Department of Medicine, Mount Sinai Hospital IBD Centre, University of Tronto, Toronto, Ontario. msilverberg@mtsinai.on.ca
authors.forename: Mark S
authors.initials: MS
authors.lastname: Silverberg
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.forename: Tariq
authors.initials: T
authors.lastname: Ahmad
authors.forename: Ian D R
authors.initials: ID
authors.lastname: Arnott
authors.forename: Charles N
authors.initials: CN
authors.lastname: Bernstein
authors.forename: Steven R
authors.initials: SR
authors.lastname: Brant
authors.forename: Renzo
authors.initials: R
authors.lastname: Caprilli
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
authors.forename: Christoph
authors.initials: C
authors.lastname: Gasche
authors.forename: Karel
authors.initials: K
authors.lastname: Geboes
authors.forename: Derek P
authors.initials: DP
authors.lastname: Jewell
authors.forename: Amir
authors.initials: A
authors.lastname: Karban
authors.forename: Edward V
authors.initials: EV
authors.lastname: Loftus
authors.forename: A Salvador
authors.initials: AS
authors.lastname: Peña
authors.forename: Robert H
authors.initials: RH
authors.lastname: Riddell
authors.forename: David B
authors.initials: DB
authors.lastname: Sachar
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.forename: A Hillary
authors.initials: AH
authors.lastname: Steinhart
authors.forename: Stephan R
authors.initials: SR
authors.lastname: Targan
authors.forename: Severine
authors.initials: S
authors.lastname: Vermeire
authors.forename: B F
authors.initials: BF
authors.lastname: Warren
mesh_terms: D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000145:classification* / Q000235:genetics / Q000503:physiopathology; D003424:Crohn Disease / Q000145:classification* / Q000235:genetics / Q000503:physiopathology; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000145:classification* / Q000235:genetics / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D005819:Genetic Markers