Copper chaperone cycling and degradation in the regulation of the cop operon of Enterococcus hirae.
Extensive insight into copper homeostasis has recently emerged. The Gram-positive bacterium Enterococcus hirae has been a paradigm for many aspects of the process. The cop operon of E. hirae consists of four genes that encode a repressor, CopY, a copper chaperone, CopZ, and two CPx-type copper ATPases, CopA and CopB. CopA and CopB accomplish copper uptake and export, respectively, and the expression of the cop operon is regulated by copper via the CopY repressor and the CopZ chaperone. The functions of the four Cop proteins have been extensively studied in vivo as well as in vitro and a detailed understanding of the regulation of the cop operon by copper has emerged.
Magnani
David
D
Department of Clinical Pharmacology, University of Berne, Switzerland.
Solioz
Marc
M
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D019327:Copper Sulfate / Q000737:chemistry; D000079922:Copper Transport Proteins; D004247:DNA / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D016983:Enterococcus / Q000378:metabolism*; D006706:Homeostasis; D066298:In Vitro Techniques; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010802:Phylogeny; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
D001426:Bacterial Proteins; D027682:Cation Transport Proteins; C071263:CopA protein, Bacteria; C092378:CopY protein, Enterococcus hirae; C092379:CopZ protein, Enterococcus hirae; D000079922:Copper Transport Proteins; D018832:Molecular Chaperones; D012097:Repressor Proteins; D015534:Trans-Activators; D003300:Copper; D004247:DNA; D000251:Adenosine Triphosphatases; C088359:CopB ATPase, Enterococcus hirae; D019327:Copper Sulfate; D010100:Oxygen