title: Serum total cholesterol, triglycerides and high density lipoproteins (HDL) levels in rabbit during the course of experimental diabetes.
abstract: The study was conducted on 56 rabbits, of White New Zealand breed, male gender. The average weight of the rabbits was 3 kg. The diabetes was evoked by intravenous injection of 10% alloxan, using the single dose of 100 mg/kg. On the 7th day after administration of alloxan, serum glucose levels were determined. The serum glucose level higher than 11.1 mmol/l was considered an indicator of the presence of diabetes. All the animals included in the study were divided into five groups: the control, 21-day diabetes, 42-day diabetes, 90-day diabetes and 180-day diabetes. Serum total cholesterol, triglycerides and high density lipoproteins levels were determined with enzymatic methods. Our studies revealed a significant increase in cholesterol and triglycerides levels. That mechanism might be responsible for faster development of atheromatosis during the course of diabetes mellitus.
authors.affiliation: Department of Human Anatomy, Skubiszewski Medical University of Lublin.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Wójtowicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wrona
authors.forename: Grazyna
authors.initials: G
authors.lastname: Kiś
authors.forename: Magdalena
authors.initials: M
authors.lastname: Błaszczak
authors.forename: Anna
authors.initials: A
authors.lastname: Solecka
mesh_terms: D000496:Alloxan; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood*
chemical_list: D008075:Lipoproteins, HDL; D014280:Triglycerides; D000496:Alloxan; D002784:Cholesterol