[Correlation of polymorphisms of UDP-glucuronosyltransferase 1A7 gene to genetic susceptibility of lung cancer].
OBJECTIVE
UDP-glucuronosyltransferase 1A7 (UGT1A7) plays an important role in detoxification through catalyzing combination of glucuronic acid and tobacco carcinogens, including benzo [alpha] pyrene, nitrosamine, and heterocyclic amine PhIP, therefore, inactivates the carcinogens. This study was to examine the correlation of polymorphisms of UGT1A7 gene to genetic susceptibility of lung cancer.


METHODS
Polymorphisms of UGT1A7 gene at 12-131 and 208 sites in peripheral lymph cells of 312 patients and 317 age- and sex-matched controls were detected by polymerase chain reaction-denaturized high performance liquid chromatography (PCR-DHPLC) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP); the correlation of these polymorphisms to genetic susceptibility of lung cancer was analyzed.


RESULTS
Compared with the UGT1A7*1/*1 genotype carriers, the UGT1A7*3/*1 genotype carriers had a 1.80-fold increased risk of lung adenocarcinoma [adjusted odds ratio (OR), 1.80; 95% confidence interval (CI), 1.03-3.12], the UGT1A7*3 genotype carriers had a 1.59-fold increased risk of lung adenocarcinoma (adjusted OR, 1.59; 95% CI, 0.96-2.63). The UGT1A7 polymorphisms had no correlation with risk of lung squamous cell carcinoma.


CONCLUSIONS
UGT1A7 gene polymorphisms may increase the genetic susceptibility of lung adenocarcinoma in Chinese.
Feng
Fei-Yue
FY
Department of Thoracic Surgery, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Liang
Gang
G
Lu
Wen-Fu
WF
Miao
Xiao-Ping
XP
Yu
Chun-Yuan
CY
Tan
Wen
W
Zhou
Yi-Feng
YF
Sun
Tong
T
Kang
Bin
B
Zhou
Tong
T
Pan
Kai-Feng
KF
Zhang
Lian
L
Lin
Dong-Xin
DX
D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014453:Glucuronosyltransferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D014453:Glucuronosyltransferase; C107611:UDP-glucuronosyltransferase, UGT1A7