Double-unit unrelated cord blood transplantation for chronic myelogenous leukemia.
We report the results of unrelated cord blood transplantation (CBT) in a 12-year-old boy with Philadelphia chromosome- positive chronic myelogenous leukemia in the chronic phase and a high body weight (68.5 kg at transplantation). Only 1 of the 2 units used engrafted. This unit was not human leukocyte antigen (HLA) class II identical with the patient and had a much larger number of nucleated cells than the other unit (approximately 2.4:1). To our knowledge, this case report is the first to describe successful CBT from two unrelated donors to a cancer patient, who had the highest body weight among CBT recipients in Taiwan.
Hung
Giun-Yi
GY
Department of Pediatrics, Taipei Veterans General Hospital, Taiwan.
Chiou
Tzeon-Jye
TJ
Chang
Chia-Yau
CY
Teng
Hao-Wei
HW
Chen
Po-Min
PM
Hwanga
Betau
B
D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy*; D008297:Male