A locus for eosinophilia in the MES rat is on Chromosome 19.
Matsumoto Eosinophilia Shinshu (MES) is a rat strain that spontaneously develops eosinophilia and eosinophil-related inflammatory lesions in many organs. We performed chromosomal mapping of the gene for eosinophilia by breeding backcross progeny. The onset of eosinophilia appeared to be delayed in the progeny compared with that in MES, with the prevalence of eosinophilia in the backcross progeny at 12 weeks of age being 22.5%. Genetic linkage analysis with marker loci indicated the major locus for eosinophilia was located at the end of the q arm region of Chromosome 19 (between D19Rat8 and telomere). The locus was denoted eosinophilia 1 (eos1). These data will form the basis for identification of the eos1 gene using a reverse genetic approach, which will hopefully lead to elucidation of the mechanisms involved in eosinophilia and eosinophilopoiesis.
Li
Guixin
G
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Guo
Zhanjun
Z
Higuchi
Keiichi
K
Kawakubo
Masatomo
M
Matsumoto
Kiyoshi
K
Mori
Masayuki
M
D000818:Animals; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000235:genetics*; D003433:Crosses, Genetic; D017931:DNA Primers; D004802:Eosinophilia / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D040641:Quantitative Trait Loci; D051381:Rats; D011922:Rats, Mutant Strains; D017422:Sequence Analysis, DNA
D017931:DNA Primers