Serum tumor necrosis factor-alpha in pre eclampsia.
Cytokines are major contributors in pathogenesis of pre eclampsia. Serum TNF-alpha was determined in 10 normal and 30 pre-eclamptic pregnant females with special reference to maternal age, parity and levels of mean arterial blood pressure. TNF-alpha was determined using sandwich ELISA technique. Serum TNF-alpha level in normal pregnant females was 9.3 +/- 0.56 pg/ml, while in pre-eclamptic pregnant females it was 67.66 +/- 61.83 pg/ml. This increase TNF-alpha was highly significant (P < 0.001). There was no significant changes in serum TNF-alpha with respect to maternal age, parity and mean arterial pressure in both normal and pre-eclamptic pregnancies.
Muzammil
Sazina
S
Department of Physiology, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh 202 001.
Singhal
Usha
U
Gulati
Rajiv
R
Bano
Imam
I
D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008423:Maternal Age; D010298:Parity; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D044967:Serum / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha