Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico.
Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.
Velázquez
Claudia
C
Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 degrees Piso, Centro Médico Nacional Siglo XXI, IMSS, Col. Doctores, CP 06725, México DF. fercalber1@hotmail.com
Calzada
Fernando
F
Torres
Javier
J
González
Felipe
F
Ceballos
Guillermo
G
D000818:Animals; D002772:Cholera Toxin / Q000494:pharmacology; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008800:Mexico; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts; D002772:Cholera Toxin