title: [Study on amplification of ZNF217 in primary gastric carcinoma].
abstract: OBJECTIVE
  To investigate amplification of zinc finger protein 217(ZNF217) and its association with clinicopathologic parameters in primary gastric carcinoma.
  
  
  METHODS
  Semiquantitative polymerase chain reaction (PCR) was used to determine DNA copies of ZNF217 in the specimens from forty- seven cases with primary gastric carcinoma.
  
  
  RESULTS
  There was no difference in DNA copies between tumor specimens and paratumor normal tissues. The incidence of ZNF217 amplification was 11.36% in gastric cancer. The amplification of ZNF217 was significantly associated with tumor size(P< 0.01) and intestinal type of stomach cancer(P< 0.05).
  
  
  CONCLUSIONS
  Oncogene ZNF217 may play a role in specific tumor types or subtypes of gastric cancer. There may be other oncogenes associated with gastric carcinoma in 20(q)13.
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. doctorzhuyq@sina.com
authors.forename: Ya-qing
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Zheng-gang
authors.initials: ZG
authors.lastname: Zhu
authors.forename: Bing-ya
authors.initials: BY
authors.lastname: Liu
authors.forename: Xue-hua
authors.initials: XH
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hao-ran
authors.initials: HR
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D015534:Trans-Activators; C113698:ZNF217 protein, human