One-stage anterior approach for four-vessel occlusion in rat.
OBJECTIVE
We report a modified 4-vessel occlusion (4VO) rat model.


METHODS
We used a 1-stage anterior approach for making bilateral hemispheric ischemia.


RESULTS
Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels.


CONCLUSIONS
This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.
Yamaguchi
Mitsuo
M
Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, USA.
Calvert
John W
JW
Kusaka
Gen
G
Zhang
John H
JH
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D002545:Brain Ischemia / Q000473:pathology*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D008297:Male; D008953:Models, Anatomic; D051381:Rats; D017207:Rats, Sprague-Dawley