title: Benign cutaneous pseudoglandular schwannoma: a case report.
abstract: Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion. In addition to typical schwannoma with classic Antoni A and Antoni B areas, many variant types have been described, such as plexiform, cellular, epithelioid, and ancient schwannomas. Glandular schwannoma is a rare variant characterized by the presence of glands in an otherwise typical schwannoma. There are also a few reported cases in the literature of pseudoglandular schwannoma from central nervous system, eye, submandible, and shoulder, in which the gland-like structures were lined by Schwann cells. We report here a patient with a benign cutaneous schwannoma composed of predominantly gland-like spaces that contained mucinous material and were lined by Schwann cells confirmed by immunohistochemistry and ultrastructural studies. The tumor was well circumscribed and showed minimal cytologic atypia, indicating benignity. We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphologic diversity of schwannoma.
authors.affiliation: Department of Dermatology, University of Maryland, Baltimore, Maryland 21201, USA. adeng@som.umaryland.edu
authors.forename: April
authors.initials: A
authors.lastname: Deng
authors.forename: John
authors.initials: J
authors.lastname: Petrali
authors.forename: David
authors.initials: D
authors.lastname: Jaffe
authors.forename: Bahram
authors.initials: B
authors.lastname: Sina
authors.forename: Anthony
authors.initials: A
authors.lastname: Gaspari
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009442:Neurilemmoma / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure