title: Expression of the immediate early gene, c-fos, in mouse brain after acute global system for mobile communication microwave exposure.
abstract: OBJECTIVE
  To study the effect of acute exposure to global system for mobile communication radiofrequency fields on immediate early gene, c-fos, expression in the brain.
  
  
  METHODS
  Using a purpose-designed exposure system at 900 MHz, mice were given a single, far-field, whole body exposure for 60 minutes at a specific absorption rate of 4 W/kg. Control mice were sham-exposed or freely mobile in a cage without further restraint. c-fos protein expression was detected immunohistochemically in perfusion-fixed brains.
  
  
  RESULTS
  Activation of c-fos in exposed and sham-exposed brains was comparable, but was greatly increased compared with freely moving controls.
  
  
  CONCLUSIONS
  These results suggest that the majority of the acute genomic response detected by c-fos expression was due to immobilisation rather than irradiation.
authors.affiliation: Veterinary Services Division, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. john.finnie@imvs.sa.gov.au
authors.forename: John W
authors.initials: JW
authors.lastname: Finnie
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D040421:Cell Phone; D016762:Genes, fos / Q000528:radiation effects*; D051379:Mice; D008872:Microwaves / Q000009:adverse effects*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology