title: Diffusion tensor imaging in progressive multifocal leukoencephalopathy: early predictor for demyelination?
abstract: Progressive multifocal leukoencephalopathy is a severe demyelinating disease of the central nervous system caused by a JC papovavirus infection. Prognosis is poor with fatal outcome within 1 year in 90% of patients. Our case report shows that diffusion tensor imaging can give early and specific information about disease status and extent in a 15-year-old girl with progressive multifocal leukoencephalopathy associated with congenital human immunodeficiency virus (HIV) infection.
authors.affiliation: Department of Diagnostic Imaging ,University Children's Hospital Zurich, Zurich, Switzerland.
authors.forename: Thierry A G M
authors.initials: TA
authors.lastname: Huisman
authors.forename: Eugen
authors.initials: E
authors.lastname: Boltshauser
authors.forename: Ernst
authors.initials: E
authors.lastname: Martin
authors.forename: David
authors.initials: D
authors.lastname: Nadal
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000821:virology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000151:congenital; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000821:virology; D011237:Predictive Value of Tests; D013997:Time Factors