title: [Risk factors and preventive steps for nasosinusitis after radiotherapy of nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To study the risk factors and preventive steps of nasosinusitis after radiotherapy of nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  Two hundreds and thirtyone NPC patients were retrospectively analysed.
  
  
  RESULTS
  Among 231 NPC patients, 98 patients (42.4%) had nasosinusitis before radiotherapy, 165 patients (66.7%) suffered from nasosinusitis after radiotherapy. The rate of nasosinusitis in NPC patients with high T stage and nasalcavity anatomical aberrance was higher than in others (P = 0.014, CR = 1. 973; P = 0. 034, OR = 2.156), and the rate of nasosinusitis in NPC patients with nasopharynx therapy was low (P = 0.008, OR = 0.675), most patients with nasosinusitis before radiotherapy had not any improve after radiotherapy,and effected the effect of radiotherapy.
  
  
  CONCLUSIONS
  To reduce nasosinusitis after radiotherapy and improve patients quality of life, we suggest that nasopharyngeal cavity therapy should be carried out during and after irradiation for NPC patients, especially for those patients with high T stage and nasalcavity anatomical aberrance, and for those who had nasosinusitis before radiotherapy.
authors.affiliation: Department of Otolaryngology, First Clinical Affiliated Hospital, Jinan University, Guangzhou, 510630, China. dl-lh1995@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Jiqun
authors.initials: J
authors.lastname: Wang
authors.forename: Lihua
authors.initials: L
authors.lastname: Wang
authors.forename: Hengguo
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000150:complications / Q000532:radiotherapy*; D012189:Retrospective Studies; D012852:Sinusitis / Q000209:etiology / Q000517:prevention & control*