Changes in progesterone-induced-blocking-factor expression rates following mifepristone administration in termination of pregnancy at 5 to 8 weeks.
OBJECTIVE
To study changes in the expression rate of PIBF by peripheral lymphocytes in healthy pregnant women after administration of mifepristone for non-surgical termination of pregnancy at 5-8 wks of gestation.


METHODS
Patients requesting early social termination of pregnancy, in a 3-month period, were included. A first venous blood sample was taken before oral administration of 600 mg of mifepristone (day 0). A second venous blood sample was taken 2 days later. PIBF on lymphocytes was determined by immunocytochemistry using a PIBF-specific polyclonal antibody.


RESULTS
Termination of pregnancy was successful and complete in all cases. In 17 out of 21 patients, the percentage of PIBF positive lymphocytes decreased after anti-progesterone administration. The percentage of PIBF-expressing lymphocytes significantly decreased from 52.8%+/-21.6% (day 0) to 39.8%+/-18.2% by day 2 (p=0.001).


CONCLUSIONS
These data suggest a strong relationship between early termination of pregnancy induced with mifepristone and disturbances of progesterone-mediated immunosuppression.
Salomon
Laurent J
LJ
Department of Obstetrics and Gynecology, Poissy-Saint Germain Hospital, Versailles-St Quentin University, France.
Rozenberg
Patrick
P
Szekeres-Bartho
Julia
J
Malagrida
Lydia
L
Giudicelli
Yves
Y
Ville
Yves
Y
D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000028:Abortion, Induced; D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D015735:Mifepristone / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000187:drug effects*; D011261:Pregnancy Trimester, First; D013491:Suppressor Factors, Immunologic / Q000008:administration & dosage*
D000021:Abortifacient Agents, Steroidal; C110058:PIBF1 protein, human; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; D015735:Mifepristone