Conversion of mouse mammary tumor virus to a lymphomagenic virus.
Type B leukemogenic virus is a variant of mouse mammary tumor virus (MMTV) that causes thymic lymphomas rather than mammary tumors in mice. We demonstrate that conversion of a mammotropic MMTV to a T-cell-tropic virus requires two alterations in the long terminal repeat: (i) acquisition of a T-cell-specific enhancer and (ii) loss of transcriptional repression through deletion of negative regulatory elements (NREs) or by suppression of NRE activity after appropriate positioning of the enhancer.
Bhadra
Sanchita
S
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712-0162, USA.
Lozano
Mary M
MM
Dudley
Jaquelin P
JP
D000818:Animals; D002460:Cell Line; D004742:Enhancer Elements, Genetic; D005809:Genes, Regulator; D006801:Humans; D019169:Jurkat Cells; D016399:Lymphoma, T-Cell / Q000821:virology; D008325:Mammary Neoplasms, Experimental / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics* / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D011533:Proviruses / Q000235:genetics / Q000472:pathogenicity; D012192:Retroviridae Infections / Q000821:virology; D013601:T-Lymphocytes / Q000821:virology; D020079:Terminal Repeat Sequences; D014158:Transcription, Genetic; D014162:Transfection; D014412:Tumor Virus Infections / Q000821:virology