Mitochondrial regulation of oxygen sensing.
Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.
Bell
Eric L
EL
Division of Pulmonary & Critical Care Medicine, Department of Medicine, Northwestern University, Chicago IL 606011, USA.
Emerling
Brooke M
BM
Chandel
Navdeep S
NS
D000818:Animals; D004579:Electron Transport; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D010100:Oxygen / Q000378:metabolism / Q000502:physiology*; D017382:Reactive Oxygen Species; D015398:Signal Transduction
D051793:Hypoxia-Inducible Factor 1; D017382:Reactive Oxygen Species; D010100:Oxygen