Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.
Linkage analyses have identified four major MS susceptibility loci in Finns. Here we have fine mapped the region on chromosome 5p in 28 Finnish MS families. Marker D5S416 provided the highest pairwise LOD score, and multipoint and haplotype analyses restrict the critical region to about 5.3 Mb on 5p15 between markers D5S1987 and D5S416. Ascertaining for HLA type and geographical origin indicated that families with and without the HLA DR15 risk haplotype, as well as families within and outside an internal high-risk region, contributed to the linkage to 5p, implying the general significance for this locus in Finnish MS families.
Riise Stensland
Hilde Monica F
HM
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Saarela
Janna
J
Bronnikov
Denis O
DO
Parkkonen
Maija
M
Jokiaho
Anne J
AJ
Palotie
Aarno
A
Tienari
Pentti J
PJ
Sumelahti
Marja-Liisa
ML
Elovaara
Irina
I
Koivisto
Keijo
K
Pirttilä
Tuula
T
Reunanen
Mauri
M
Sobel
Eric
E
Peltonen
Leena
L
D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D005387:Finland; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000235:genetics*
D006684:HLA-DR Antigens