title: Apoptosis and traumatic brain injury.
abstract: Traumatic brain injury is a cause of high mortality and morbidity and is an area of intense research. Apoptosis plays a crucial role in the pathogenesis of head injury, and the inhibition of apoptosis can potentially reverse the deleterious effects and lead to better functional outcome. Elucidation of the apoptotic pathway and its role in traumatic brain injury will provide potential targets for therapeutic intervention. This article aims to review the current wealth of literature on apoptosis and traumatic head injury and explores the current status of therapeutic strategies available.
authors.affiliation: Acute Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore.
authors.forename: Jill
authors.initials: J
authors.lastname: Wong
authors.forename: Ng Wai
authors.initials: NW
authors.lastname: Hoe
authors.forename: Feng
authors.initials: F
authors.lastname: Zhiwei
authors.forename: Ivan
authors.initials: I
authors.lastname: Ng
mesh_terms: D017209:Apoptosis; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans