title: Eptifibatide does not influence lymphocyte activation and CRP levels in patients with undergoing coronary angioplasty.
abstract: Inhibitors of the IIB-IIIA integrin are widely used to prevent stent thrombosis. Abciximab has been shown to attenuate the inflammatory response in patients undergoing PCI. Herein, we tested the effect of eptifibatide infused during PCI on peripheral lymphocyte activation and CRP levels before, and one month after the procedure showing no noticeable effect. These results may explain the differences in clinical outcome following PCI by use of different IIB-IIIA agents.
authors.affiliation: The Department of Cardiology, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Finkelstein
authors.forename: Sabina
authors.initials: S
authors.lastname: Izraelov
authors.forename: Arie
authors.initials: A
authors.lastname: Roth
authors.forename: Sigal
authors.initials: S
authors.lastname: Ben-Shmuel
authors.forename: Gad
authors.initials: G
authors.lastname: Keren
authors.forename: Hylton
authors.initials: H
authors.lastname: Miller
authors.forename: Jacob
authors.initials: J
authors.lastname: George
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000187:drug effects* / Q000378:metabolism; D016516:CD4-CD8 Ratio; D000077542:Eptifibatide; D005260:Female; D005500:Follow-Up Studies; D006684:HLA-DR Antigens / Q000097:blood / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D015607:Stents; D013997:Time Factors
chemical_list: D006684:HLA-DR Antigens; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D002097:C-Reactive Protein; D000077542:Eptifibatide