Diabetic Nephropathy: A review of the Past, Present and Future Perspectives - Part 2.
Diabetic renal disease is a serious problem resulting from microvascular complications in both type 1 and type 2 diabetes mellitus. There is increased mortality from cardiovascular causes in patients with diabetic nephropathy. However, in spite of plethora of studies in recent years on the possible pathogenetic mechanisms involved in diabetic nephropathy, the exact role of each individual mechanism is still inconclusive. Diabetic nephropathy is reviewed in two parts, the first part deals with historical background, pathophysiology and pathogenesis including the roles of chronic hyperglycaemia, renin-angiotensin system and several mediators in the renal changes in diabetes mellitus. While the second part reviews the treatment as well as current theories in treatment and possible intervention strategies of the future. Key words: diabetic nephropathy, microalbuminuria, pathogenesis, renin-angiotensin system, pathophysiology, treatment.
Ulasi
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Renal Unit, Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria. ifeomaulasi@yahoo.co.uk.
D000419:Albuminuria; D002318:Cardiovascular Diseases; D003920:Diabetes Mellitus; D003924:Diabetes Mellitus, Type 2; D003928:Diabetic Nephropathies; D006801:Humans; D006943:Hyperglycemia; D009549:Nigeria