title: [Role of human immunodeficiency virus in leukocytes apoptosis from infected patients].
abstract: The hallmark of the immunodeficiency virus infection is a progressive detriment of the immune response which has been associated to a gradual loss of its responsible components, in particularly, CD4 positive T cells. Although this cell population is considered the main target of the virus, there is a recent deal of interest in studying other components that may not be targets of the virus, but are important elements to control infectious microorganisms and that have been demonstrated to be altered during HIV infection. Neutrophils (PMN) are innate immune components that play a fundamental role against HIV infection and these cells have been described as functionally altered during AIDS. It has been suggested that such a dysfunction could be attributed to an increased susceptibility of these cells to accelerated spontaneous apoptosis. However, the underlying mechanisms that induce programmed cell death of neutrophils remain unknown. In previous works we have explored some events involved during cell death of neutrophils from HIV infected patients. It is the purpose of this work to review the current knowledge of apoptosis signals in neutrophils and to discuss our own data about some mechanisms involved in spontaneous and Fas mediated apoptosis, which may contribute to understand neutrophils dysfunction during HIV infection.
authors.affiliation: Instituto de Inmunología Clínica, Facultad de Medicina, Universidad de Los Andes, Mérida, Venezuela.
authors.forename: Siham
authors.initials: S
authors.lastname: Salmen
authors.forename: Carolina
authors.initials: C
authors.lastname: Guillermo
authors.forename: Melisa
authors.initials: M
authors.lastname: Colmenares
authors.forename: Luisa
authors.initials: L
authors.lastname: Barboza
authors.forename: Loredana
authors.initials: L
authors.lastname: Goncalves
authors.forename: Guillermo
authors.initials: G
authors.lastname: Terán
authors.forename: Nacarid
authors.initials: N
authors.lastname: Alfonso
authors.forename: Henry
authors.initials: H
authors.lastname: Montes
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Berrueta
mesh_terms: D017209:Apoptosis; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*