Heck-type 5-endo-trig cyclization promoted by vinylic fluorines: synthesis of 5-fluoro-3H-pyrroles.
A 5-endo-trig alkene insertion proceeds under palladium catalysis via aminopalladium species starting from 3,3-difluoroallyl ketone O-pentafluorobenzoyloximes, providing a facile access to 5-fluoro-3H-pyrroles.
Sakoda
Kotaro
K
Department of Chemistry, Graduate School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Mihara
Jun
J
Ichikawa
Junji
J