title: Exclusive low-dose-rate brachytherapy in 279 patients with T2N0 mobile tongue carcinoma.
abstract: OBJECTIVE
  To evaluate the therapeutic results obtained with (192)Ir low-dose-rate interstitial brachytherapy in T2N0 mobile tongue carcinoma.
  
  
  METHODS
  Between December 1979 and January 1998, 279 patients with T2N0 mobile tongue carcinoma were treated by exclusive low-dose-rate brachytherapy, with or without neck dissection. (192)Ir brachytherapy was performed according to the "Paris system" with a median total dose of 60 Gy (median dose rate, 0.5 Gy/h).
  
  
  RESULTS
  Overall survival was 74.3% and 46.6% at 2 and 5 years. Local control was 79.1% at 2 years and regional control, respectively, 75.9% and 69.5% at 2 and 5 years (Kaplan-Meier method). Systematic dissection revealed 44.6% occult node metastases, and histologic lymph node involvement was identified as the main significant factor for survival. Complication rate was 16.5% (Grade 3, 2.9%). Half of the patients presented previous and/or successive malignant tumor (ear-nose-throat, esophagus, or bronchus).
  
  
  CONCLUSIONS
  Exclusive low-dose-rate brachytherapy is an effective treatment for T2 tongue carcinoma. Regional control and survival are excellent in patients undergoing systematic neck dissection, which is mandatory in our experience because of a high rate of occult lymph node metastases.
authors.affiliation: Department of Radiotherapy, Centre Oscar Lambret, 3 rue Frédéric Combemale, 59000 Lille, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Bourgier
authors.forename: Bernard
authors.initials: B
authors.lastname: Coche-Déquéant
authors.forename: Charles
authors.initials: C
authors.lastname: Fournier
authors.forename: Bernard
authors.initials: B
authors.lastname: Castelain
authors.forename: Bernard
authors.initials: B
authors.lastname: Prévost
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Lefebvre
authors.forename: Eric
authors.initials: E
authors.lastname: Lartigau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D007496:Iridium Radioisotopes