title: The descriptive epidemiology of severe lower respiratory tract infections in children in Kiel, Germany.
abstract: BACKGROUND
  Lower respiratory tract infections (LRI) inflict a high burden of disease in children worldwide. Longitudinal, descriptive epidemiological data on different forms of LRI are urgently needed to differentiate this burden, compare population-based incidence rates between countries and to recognize trends.
  
  
  METHODS
  From July 1996 to June 2000, all children hospitalized with LRI, i. e. laryngo-tracheo-bronchitis (LTB), bronchitis, wheezing bronchitis-bronchiolitis (WBB), bronchopneumonia and pneumonia, in the municipal area of Kiel, Schleswig-Holstein, Germany, were analyzed by cross-sectional studies. Naso-pharyngeal aspirates (NPA) were analyzed by an in-house 9-valent multiplex-RT-PCR.
  
  
  RESULTS
  In the 4-year observational period, 1 072 children aged 0 to 16 years (median 23 months) were hospitalized with LRI: 12 % (median 28 months) with LTB, 11 % (median 17 months) with bronchitis, 28 % (median 13 months) with WBB, 26 % (median 26 months) with bronchopneumonia and 22 % (median 47 months) with pneumonia. The prevalence of chronic underlying conditions (20 %) and low gestational age (13 %) varied in the different forms of LRI. The cumulative incidence rate of LRI rose steadily over the 4 years. The highest fraction was contributed by WBB, while pneumonia declined. The highest incidence rate ratio was attributable to respiratory syncytial virus (RSV, 0.46) and to children under 2 years of age.
  
  
  CONCLUSIONS
  LRI, especially obstructive forms of LRI, are increasing in Germany as described earlier for the USA, UK and Sweden. The major burden is carried by children under 2 years. RSV is the single pathogen with the highest impact.
authors.affiliation: Pediatric Infectious Diseases, Department of General Pediatrics, University of Kiel, Germany. weigl@pediatrics.uni-kiel.de
authors.forename: J A I
authors.initials: JA
authors.lastname: Weigl
authors.forename: W
authors.initials: W
authors.lastname: Puppe
authors.forename: O
authors.initials: O
authors.lastname: Belke
authors.forename: J
authors.initials: J
authors.lastname: Neusüss
authors.forename: F
authors.initials: F
authors.lastname: Bagci
authors.forename: H J
authors.initials: HJ
authors.lastname: Schmitt
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001988:Bronchiolitis / Q000453:epidemiology; D001991:Bronchitis / Q000453:epidemiology; D001996:Bronchopneumonia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007827:Laryngitis / Q000453:epidemiology; D008297:Male; D008458:Measles Vaccine / Q000008:administration & dosage; D011014:Pneumonia / Q000453:epidemiology; D015995:Prevalence; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology; D012141:Respiratory Tract Infections / Q000453:epidemiology*; D012621:Seasons; D012737:Sex Factors; D014136:Tracheitis / Q000453:epidemiology
chemical_list: D008458:Measles Vaccine