Compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration.
OBJECTIVE
The physical and chemical compatibility of palonosetron with cyclophosphamide and with ifosfamide during simulated Y-site administration was studied.


METHODS
Test samples were prepared in triplicate by mixing 7.5 mL of palonosetron hydrochloride 50 microg (of palonosetron) per milliliter with 7.5 mL of cyclophosphamide 10 mg/mL and with ifosfamide 20 mg/mL. Physical stability was assessed by turbidimetry, particle sizing, and visual inspection. Chemical stability was assessed by stability-indicating high-performance liquid chromatography. Evaluations were performed immediately and one and four hours after mixing.


RESULTS
The samples were clear and colorless when viewed in normal fluorescent room light and when viewed with a high-intensity monodirectional light. Turbidity remained unchanged, and particulate content was low and exhibited little change. Palonosetron, cyclophosphamide, and ifosfamide remained chemically stable throughout the four-hour test period.


CONCLUSIONS
Palonosetron hydrochloride was physically compatible with cyclophosphamide or ifosfamide during simulated Y-site administration.
Xu
Quanyun A
QA
Division of Pharmacy, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Trissel
Lawrence A
LA
D000932:Antiemetics / Q000737:chemistry*; D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003520:Cyclophosphamide / Q000737:chemistry*; D004355:Drug Stability; D005947:Glucose; D007069:Ifosfamide / Q000737:chemistry*; D007262:Infusions, Intravenous; D007546:Isoquinolines / Q000737:chemistry*; D000077924:Palonosetron; D019999:Pharmaceutical Solutions; D011812:Quinuclidines / Q000737:chemistry*
D000932:Antiemetics; D018906:Antineoplastic Agents, Alkylating; D007546:Isoquinolines; D019999:Pharmaceutical Solutions; D011812:Quinuclidines; D000077924:Palonosetron; D003520:Cyclophosphamide; D005947:Glucose; D007069:Ifosfamide