title: Film formation from colloidal dispersions stabilized by sugar derivatives and their controllable release for selective protein adsorption.
abstract: Although the use of sugar and sugar derivatives has been documented in polymer research for many years, there are no reports that would utilize these species as polymerization sites of colloidal polymeric particles that, later on, may be released during particle coalescence to form films with surfaces that differentiate protein adsorption. These studies show that, when n-dodecyl-beta-D-maltoside (DDM) is utilized for the synthesis and stabilization of poly[methyl methacrylate-co-(n-butyl acrylate)] (p-MMA/nBA) colloidal particles, upon particle coalescence DDM stratifies near the film-air (F-A) interface. By using attenuated total reflectance Fourier transform infrared (ATR FT-IR) spectroscopy and internal reflection infrared imaging (IRIRI), comparative adsorption studies on p-MMA/nBA surfaces exposed to globulin (Glo), fibrinogen (Fib), and bovine serum albumin (BSA) reveal that the presence of DDM selectively inhibits Glo and Fib adsorption, but does not affect BSA. The presence of DDM also enhances the rate of mobility of sodium dioctylsulfosuccinate (SDOSS) resulting from interactions between DDM and SDOSS moieties, and the surface morphologies change as a result of concentration variations of DDM in the colloidal dispersions.
authors.affiliation: School of Polymers and High Performance Materials, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, USA.
authors.forename: Woo-Sung
authors.initials: WS
authors.lastname: Bae
authors.forename: David J
authors.initials: DJ
authors.lastname: Lestage
authors.forename: Michael
authors.initials: M
authors.lastname: Proia
authors.forename: Sabine
authors.initials: S
authors.lastname: Heinhorst
authors.forename: Marek W
authors.initials: MW
authors.lastname: Urban
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000327:Adsorption; D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002241:Carbohydrates / Q000737:chemistry; D003102:Colloids / Q000737:chemistry*; D004143:Dioctyl Sulfosuccinic Acid / Q000737:chemistry; D016503:Drug Delivery Systems; D005340:Fibrinogen / Q000737:chemistry; D005898:Glass; D005916:Globulins / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D008768:Methylmethacrylates / Q000737:chemistry; D008954:Models, Biological; D011108:Polymers / Q000737:chemistry; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013696:Temperature
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D001704:Biopolymers; D002241:Carbohydrates; D003102:Colloids; D005916:Globulins; D005960:Glucosides; D008768:Methylmethacrylates; D011108:Polymers; D011506:Proteins; C506478:poly(methyl methacrylate-co-(n-butyl acrylate)); D004143:Dioctyl Sulfosuccinic Acid; C040358:dodecyl maltoside; C032490:n-butyl acrylate; D005340:Fibrinogen