[The peripheral polyneuropathy in patients with chronic HCV infection treated peginterferon alfa with ribavirin].
IFN-alpha maybe stimulate to synthesis of autoantibodies which damaging of myelin sheath at peripheral neurons. We report the patient, man, with hepatitis C infection who was treated with peginterferon alfa-2a by one month and next with peginterferon alfa-2b by 3 months in combination with ribavirin. We observed paresis of hands and legs in fourth months of treatment. This patient's dust of difficulty with walking. In EMG investigation was detected demyelin damage of sensor motor nerves. These changes were on whole length or in distal part of neuron. It is qualified hard whether cause of peripheral polineuropathy: interferon's or pegylated part. The finished of antiviral treatments as well as use of steroids in therapy were reason of fast improvement of patients.
Lapiński
Tadeusz Wojciech
TW
Klinika Obserwacyjno-Zakaźna Akademii Medycznej, Białymstoku. twlapinski@wp.pl
Nowacka
Bozena
B
Michalewicz
Małgorzata
M
D000998:Antiviral Agents / Q000009:adverse effects*; D001323:Autoantibodies; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology*; D011115:Polyneuropathies / Q000209:etiology*; D012254:Ribavirin / Q000009:adverse effects*; D016896:Treatment Outcome
D000998:Antiviral Agents; D001323:Autoantibodies; D016898:Interferon-alpha; D012254:Ribavirin