Can whole brain nerve conduction velocity be derived from surface-recorded visual evoked potentials? A re-examination of Reed, Vernon, and Johnson (2004).
Reed, Vernon, and Johnson [Reed, T. E., Vernon, P. A., & Johnson, A. M. (2004). Sex difference in brain nerve conduction velocity in normal humans. Neuropsychologia, 42, 1709-1714] reported that "nerve conduction velocity" (NCV) of visual transmission from retina to the primary visual area (V1) is significantly faster in males than females. The authors estimated the NCV by dividing head length (nasion-to-inion distance) by the latency of the well-known P100 component of the visual evoked potential (VEP). Here, we critically examine these metrics and we contend that knowledge of the underlying physiology of neural transmission across the initial stages of the visual processing hierarchy dictates that a number of their assumptions cannot be reasonably upheld. Alternative, and we believe, more parsimonious interpretations of the data are also proposed.
Saint-Amour
Dave
D
The Cognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Saron
Clifford D
CD
Schroeder
Charles E
CE
Foxe
John J
JJ
D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D012727:Sex Characteristics; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology