title: Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry.
abstract: Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.
authors.affiliation: Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands.
authors.forename: Dirk T S
authors.initials: DT
authors.lastname: Rijkers
authors.forename: G Wilma
authors.initials: GW
authors.lastname: van Esse
authors.forename: Remco
authors.initials: R
authors.lastname: Merkx
authors.forename: Arwin J
authors.initials: AJ
authors.lastname: Brouwer
authors.forename: Hans J F
authors.initials: HJ
authors.lastname: Jacobs
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Pieters
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D001386:Azides / Q000737:chemistry; D003500:Cyclization; D050091:Dendrimers / Q000138:chemical synthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis*; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001386:Azides; D050091:Dendrimers; D010455:Peptides; D012997:Solvents