First trimester uterine artery Doppler abnormalities predict subsequent intrauterine growth restriction.
OBJECTIVE
This study was undertaken to evaluate the association between uterine artery Doppler velocimetry performed between 10 and 14 weeks gestation and intrauterine growth restriction (IUGR).


METHODS
Uterine artery Doppler velocimetry data were collected on 1067 women enrolled in the FASTER trial at the University of Colorado site. The data were analyzed by using univariate and multivariable logistic regression analysis.


RESULTS
The uterine artery mean resistance index (RI) for the entire cohort was equal on the right and left sides (0.59 +/- 0.14). Of the 1067 women, 34.2% had unilateral or bilateral diastolic notches, 1 notch was observed in 23.8%, and bilateral notches in 10.4%. Women with a high uterine artery mean RI (> or = 75th percentile) were 5.5 times more likely to have IUGR (95% CI 1.6-18.7). There was no significant relationship between notching and IUGR.


CONCLUSIONS
Elevated first trimester uterine artery mean RI is significantly associated with IUGR.
Dugoff
Lorraine
L
Department of Obstetric and Gynecology, University of Colorado Health Sciences Center, Denver, CO, USA.
Lynch
Anne M
AM
Cioffi-Ragan
Darleen
D
Hobbins
John C
JC
Schultz
Lisa K
LK
Malone
Fergal D
FD
D'Alton
Mary E
ME
D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012212:Rheology; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging