title: [Glucocorticoid-induced osteoporosis: review and proposition for prevention and treatment guidelines].
abstract: Glucocorticoids are the most frequent cause of secondary osteoporosis. They are responsible for both inadequate quantitative and qualitative effects on bone, primarily on osteoblasts (decreased activity and apoptosis). Studies have shown that patients taking glucocorticoids have decreased bone mineral density and increased risk for fractures, especially for postmenopausal women. Prevention of glucocorticoid-induced osteoporosis includes use of the lowest effective glucocorticoid dose possible, calcium and vitamin D supplementation, hormone replacement therapy and adequate physical activity. Prevention of fractures also includes all those factors that can influence the balance (e.g. muscle strenghtening, walking aids, architectonic barriers). Antiresorptive drugs should be started in all the patients with increased risk for osteoporosis, and among them bisphosphonates are the first drugs of choice.
authors.affiliation: Klinika za reumatologiju, fizikalnu medicinu i rehabilitaciju Medicinskog fakulteta SveuMilista u Zagrebu, KB Sestre milosrdnice, Zagreb.
authors.forename: Simeon
authors.initials: S
authors.lastname: Grazio
authors.forename: Mirko
authors.initials: M
authors.lastname: Korsić
authors.forename: Branimir
authors.initials: B
authors.lastname: Anić
authors.forename: Mira
authors.initials: M
authors.lastname: Vitezić-Misjak
authors.forename: Frane
authors.initials: F
authors.lastname: Grubisić
mesh_terms: D001842:Bone and Bones / Q000187:drug effects; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control / Q000628:therapy
chemical_list: D005938:Glucocorticoids