title: Circadian dysfunction reduces lifespan in Drosophila melanogaster.
abstract: Circadian clocks regulate physiological and behavioral processes in a wide variety of organisms, and any malfunction in these clocks can cause significant health problems. In this paper, we report the results of our study on the physiological consequences of circadian dysfunction (malfunctioning of circadian clocks) in two wild-type populations of fruit flies (Drosophila melanogaster). We assayed locomotor activity behavior and lifespan among adult flies kept under constant dark (DD) conditions of the laboratory, wherein they were categorized as rhythmic if their activity/rest schedules followed circadian (approximately 24 h) patterns, and as arrhythmic if their activity/rest schedules did not display any pattern. The rhythmic flies from both populations lived significantly longer than the arrhythmic ones. Based on these results, we conclude that circadian dysfunction is deleterious, and proper functioning of circadian clocks is essential for the physiological well being of D. melanogaster.
authors.affiliation: Chronobiology Laboratory, Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, India.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kumar
authors.forename: Ambika
authors.initials: A
authors.lastname: Mohan
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Sharma
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology*; D008027:Light; D008136:Longevity / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology