The continuing saga of p53--more sleepless nights ahead.
Despite previous assumptions that the tumor suppressor protein p53 exists primarily and functionally as a single species, recent papers document the existence and unexpected properties of numerous p53 isoforms in cells. The complexity of p53 continues to unfold.
Prives
Carol
C
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Manfredi
James J
JJ
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D020033:Protein Isoforms; D016159:Tumor Suppressor Protein p53