title: Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein.
abstract: Dysfunction of proteins involved in the G1 to S transition of the cell cycle, such as p16(INK4A) and RB1, is common in many cancer types. A screen of p16 protein expression was performed in benign, borderline, and invasive ovarian tumors, together with endometrial cancers, aligned on a tissue microarray. We observed frequent p16 overexpression in serous papillary carcinomas of ovarian and endometrial origin. An extended cohort of ovarian serous papillary carcinomas was examined to further evaluate the frequency of p16 overexpression. Strong, uniform staining in the majority of cancer cells occurred commonly in invasive serous papillary ovarian cancers, particularly in grade 3 carcinomas. RB1 protein expression abnormalities were rare. Our data indicate that abnormalities in the retinoblastoma pathway, as determined by p16 overexpression, are common in serous papillary carcinomas and are probably an early event.
authors.affiliation: Department of Anatomical Pathology, St. Vincent's Hospital, Fitzroy, Australia. jane.armes@mater.org.au
authors.forename: Jane E
authors.initials: JE
authors.lastname: Armes
authors.forename: Rohan
authors.initials: R
authors.lastname: Lourie
authors.forename: Melanie
authors.initials: M
authors.lastname: de Silva
authors.forename: Georgia
authors.initials: G
authors.lastname: Stamaratis
authors.forename: Alison
authors.initials: A
authors.lastname: Boyd
authors.forename: Beena
authors.initials: B
authors.lastname: Kumar
authors.forename: Gareth
authors.initials: G
authors.lastname: Price
authors.forename: Simon
authors.initials: S
authors.lastname: Hyde
authors.forename: David
authors.initials: D
authors.lastname: Allen
authors.forename: Peter
authors.initials: P
authors.lastname: Grant
authors.forename: Deon J
authors.initials: DJ
authors.lastname: Venter
mesh_terms: D000328:Adult; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis*; D018283:Cystadenocarcinoma, Papillary / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D016160:Retinoblastoma Protein / Q000502:physiology*
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D016160:Retinoblastoma Protein