title: Molecular cloning and characterization of monoamine oxidase A and B genes in pig.
abstract: Monoamine oxidase (MAO) is a key enzyme in the degradation of monoamine neurotransmitters, which are physiologically and pathologically important for animals and humans. MAO exists in two forms, coded by separate genes. Here we cloned and sequenced full length cDNAs of MAO-A and MAO-B in pig. The putative proteins include 527 and 520 amino acids, respectively. The sequences alignment and homology analysis showed that MAO-A and MAO-B are conserved among mammals. The amino acid residues and domains, which have been demonstrated to be important for MAO-A and MAO-B binding of ligands, substrates and inhibitors, were conserved in the pig.
authors.affiliation: Department of Animal Science, Agriculture and Biology College, Shanghai Jiao Tong University, P.R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Bai
authors.forename: He
authors.initials: H
authors.lastname: Meng
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000588:Amines / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D008995:Monoamine Oxidase / Q000235:genetics*; D018377:Neurotransmitter Agents / Q000737:chemistry; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D012313:RNA / Q000737:chemistry; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013552:Swine; D014018:Tissue Distribution
chemical_list: D000588:Amines; D018076:DNA, Complementary; D018377:Neurotransmitter Agents; D012313:RNA; D008995:Monoamine Oxidase