Combination of nucleoside analogues tiazofurin and ribavirin downregulates experimental autoimmune encephalomyelitis.
The effect of combined treatment with ribavirin and tiazofurin on the development of experimental autoimmune encephalomyelitis, the best characterized animal model for human autoimmune disease multiple sclerosis, was investigated. The disease was induced in highly susceptible Dark Agouti rats with spinal cord homogenate in complete Freund's adjuvant. Although ribavirin or tiazofurin alone reduced the clinical and histopathological signs of experimental autoimmune encephalomyelitis, the combination of drugs achieved the same effect with significantly lower doses.
Lavrnja
Irena
I
Department of Neurobiology and Immunology, Institute for Biological Research Sinisa Stanković, Belgrade, Serbia & Montenegro. irenam@ibiss.bg.ac.yu
Stojkov
Danijela
D
Peković
Sanja
S
Subasic
Sanja
S
Mostarica-Stojković
Marija
M
Stosic-Grujicić
Stanislava
S
Nedeljković
Nadezda
N
Medic-Mijacević
Ljubica
L
Rakić
Ljubisav
L
Stojiljkovi
Mirjana
M
D000818:Animals; D015536:Down-Regulation; D004338:Drug Combinations; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D005620:Freund's Adjuvant / Q000627:therapeutic use; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors
D004338:Drug Combinations; D012254:Ribavirin; D005620:Freund's Adjuvant; C033706:tiazofurin