Avian influenza virus: prospects for prevention and control by vaccination.
Although vaccination does not always prevent infection of avian influenza (AI) virus, the clear benefit of vaccination is in its ability to prevent disease and to reduce the amount of virus in circulation. Thus, judicious use of vaccination can be an important component of an AI control program. However, the long-term use of vaccination without eradication may result in the selection of the antigenically divergent strains, which compromises the value of vaccination. In this review, the effectiveness of currently available and future AI vaccines is discussed with suggestions for the ideal use of vaccination even with antigenic drift of the virus.
Lee
Chang-Won
CW
Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA.
Suarez
David L
DL
D000818:Animals; D001717:Birds; D009980:Influenza A virus / Q000276:immunology*; D005585:Influenza in Birds / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines
D014765:Viral Vaccines