The actin cytoskeleton in ageing and apoptosis.
Regulated cell death, or apoptosis, has evolved to fulfil a myriad of functions amongst multicellular organisms. It is now apparent that programmed cell death occurs in unicellular organisms such as yeast. In yeast, as in higher eukaryotes, the actin cytoskeleton is an essential component of a number of cellular activities, and many of the regulatory proteins involved are highly conserved. Recent evidence from diverse eukaryotic systems suggests that the actin cytoskeleton has a role in regulating apoptosis via interactions with the mitochondria. This interaction also appears to have a significant impact on the management of oxidative stress and so cellular ageing. In this mini-review we summarise some of the work, which suggests that actin is a key regulator of apoptosis and ageing in eukaryotic cells.
Gourlay
Campbell W
CW
Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Western Bank S10 2TN England, UK.
Ayscough
Kathryn R
KR
D000199:Actins / Q000502:physiology; D017209:Apoptosis; D016922:Cellular Senescence; D003599:Cytoskeleton / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction; D015003:Yeasts / Q000502:physiology*
D000199:Actins