title: [Severe hyperkalemia associated to the use of losartan and spironolactone: case report].
abstract: Hyperkalemia is a complications of the use of angiotensin converting enzyme inhibitors, angiotensin receptor antagonists and aldosterone antagonists. These drugs are commonly used for the treatment of hypertension and cardiac failure. We report a 84 year-old female treated with losartan 50 mg/day and spironolactone 25 mg/day that presented with a hyperkalemia of 8.4 mEq/l and bradicardia, drowsiness and respiratory depression. She required hemodialysis and ventilatory assistance. She was discharged in good conditions five days after admission.
authors.affiliation: Unidad de Cuidados Coronarios e Intermedio Coronario, Clínica Las Condes, Santiago, Chile. roka@clinicalascondes.cl
authors.forename: Ronald
authors.initials: R
authors.lastname: Kauffmann
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Orozco
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Venegas
mesh_terms: D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D006973:Hypertension / Q000188:drug therapy; D019808:Losartan / Q000009:adverse effects*; D012720:Severity of Illness Index; D013148:Spironolactone / Q000009:adverse effects*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D013148:Spironolactone; D019808:Losartan