title: Silica and asbestos exposure in ANCA-associated vasculitis with pulmonary involvement.
abstract: Silica and asbestos exposure are thought to belong to the triggering factors of antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis. We carried out a study to find out whether patients with pulmonary involvement attributable to ANCA-associated vasculitis (AAV) have been exposed to silicon-containing materials. Thirty-one patients (12 women, 19 men, median age 51 years) were interviewed using a structured questionnaire. Occupational exposure to silicon-containing chemicals was reported by 22.6% of the patients (12.9% to SiO2, 9.7% to asbestos), compared with 0% of control subjects (p<0.05). Our findings support the pathophysiologic role of silica in AAV.
authors.affiliation: Nephrology Unit, 1st Medical Faculty, Charles University, Prague, Czech Republic. zrihova@centrum.cz
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Rihova
authors.forename: Dita
authors.initials: D
authors.lastname: Maixnerova
authors.forename: Eva
authors.initials: E
authors.lastname: Jancova
authors.forename: Daniela
authors.initials: D
authors.lastname: Pelclova
authors.forename: Jirina
authors.initials: J
authors.lastname: Bartunkova
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Fenclova
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Vankova
authors.forename: Jana
authors.initials: J
authors.lastname: Reiterova
authors.forename: Miroslav
authors.initials: M
authors.lastname: Merta
authors.forename: Romana
authors.initials: R
authors.lastname: Rysava
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tesar
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D001194:Asbestos / Q000009:adverse effects*; D001195:Asbestosis / Q000453:epidemiology* / Q000209:etiology; D018153:Czech Republic / Q000453:epidemiology; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000453:epidemiology* / Q000209:etiology; D011795:Surveys and Questionnaires; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001194:Asbestos; D012822:Silicon Dioxide