title: Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe.
abstract: A case is presented of a patient who developed acute hepatitis during cholesterol-lowering treatment with atorvastatin and ezetimibe. Further investigations reveal a probable drug-induced autoimmune hepatitis, and ezetimibe is considered to be the most likely causal agent. This case is the first report of an autoimmune hepatitis associated with ezetimibe therapy.
authors.affiliation: Clinical Laboratories, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK. charles.vanheyningen@aht.nwest.nhs.uk
authors.forename: Charles
authors.initials: C
authors.lastname: van Heyningen
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects*; D000069059:Atorvastatin; D001384:Azetidines / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D000069438:Ezetimibe; D005260:Female; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000503:physiopathology; D006538:Heptanoic Acids / Q000009:adverse effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000503:physiopathology; D008111:Liver Function Tests; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects*
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin; D000069438:Ezetimibe