title: New cytotoxic-antineoplastic prenyl-1,2-naphthohydroquinone derivatives.
abstract: Several new prenylnaphthohydroquinone derivatives have been prepared through the Diels-Alder condensation between alpha-myrcene and 1,2-benzoquinone and evaluated for their cytotoxic activity against A-549, HT-29 and MB-231 cultured cell lines. All of them have shown GI50 values in the microM level.
authors.affiliation: Instituto de Química, Pontificia Universidad Católica de Valparaíso, Avenida Brasil 2950, Valparaíso, Chile. amolinar@ucv.cl
authors.forename: Aurora
authors.initials: A
authors.lastname: Molinari
authors.forename: Alfonso
authors.initials: A
authors.lastname: Oliva
authors.forename: Claudia
authors.initials: C
authors.lastname: Ojeda
authors.forename: José Maria
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: Castro
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D007536:Isomerism; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D011299:Prenylamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D009285:Naphthoquinones; C507108:prenyl-1,2-naphthohydroquinone; D011299:Prenylamine