title: Increased plasma levels of TNF-alpha but not of IL1-beta in MPTP-treated monkeys one year after the MPTP administration.
abstract: The cause of Parkinson's disease remains unknown although some evidence suggests that an inflammatory reaction, mediated by cytokines such as TNF-alpha and IL-1beta, is related with dopaminergic degeneration in the brain. In the present work we measured the plasma levels of TNF-alpha and IL-1beta in parkinsonian monkeys one year after MPTP administration. TNF-alpha levels were seen to have increased in parkinsonian monkeys reflecting the clinical symptoms observed, while IL-1beta levels remained unchanged. These results suggest that TNF-alpha plays a role in sustaining of dopaminergic degeneration in chronic parkinsonism.
authors.affiliation: Experimental Neurology and Neurosurgery, Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain. barcia@um.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Barcia
authors.forename: Vicente
authors.initials: V
authors.lastname: de Pablos
authors.forename: Víctor
authors.initials: V
authors.lastname: Bautista-Hernández
authors.forename: Angel
authors.initials: A
authors.lastname: Sánchez-Bahillo
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Bernal
authors.forename: Emiliano
authors.initials: E
authors.lastname: Fernández-Villalba
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
authors.forename: Rafael
authors.initials: R
authors.lastname: Bañón
authors.forename: Andrés
authors.initials: A
authors.lastname: Fernández-Barreiro
authors.forename: María-Trinidad
authors.initials: MT
authors.lastname: Herrero
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000502:physiology; D007375:Interleukin-1 / Q000097:blood*; D008252:Macaca fascicularis; D008297:Male; D009410:Nerve Degeneration / Q000097:blood / Q000276:immunology; D009498:Neurotoxins / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000097:blood / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D009498:Neurotoxins; D014409:Tumor Necrosis Factor-alpha; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine