title: Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551.
abstract: Malnutrition is common in the developing world, where tuberculosis is often endemic. Rabbits infected with aerosolized Mycobacterium tuberculosis that subsequently became inadvertently and transiently malnourished had compromised cell-mediated immunity comparable to that of the rabbits immunosuppressed with dexamethasone. They had significant leukopenia and reduced delayed-type hypersensitivity responses. Malnutrition dampened cell-mediated immunity and would interfere with diagnostic tests that rely on intact CD4 T-cell responses.
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
authors.forename: Anup K
authors.initials: AK
authors.lastname: Kesavan
authors.forename: Susana E
authors.initials: SE
authors.lastname: Mendez
authors.forename: Christine L
authors.initials: CL
authors.lastname: Hatem
authors.forename: Javier
authors.initials: J
authors.lastname: Lopez-Molina
authors.forename: Katherine
authors.initials: K
authors.lastname: Aird
authors.forename: M Louise M
authors.initials: ML
authors.lastname: Pitt
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Dannenberg
authors.forename: Yukari C
authors.initials: YC
authors.lastname: Manabe
mesh_terms: D000336:Aerosols; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003907:Dexamethasone / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D008168:Lung / Q000382:microbiology; D044342:Malnutrition / Q000276:immunology*; D009169:Mycobacterium tuberculosis; D011817:Rabbits; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D000336:Aerosols; D003907:Dexamethasone