Protective role of neutrophils in mice experimentally infected with Rhodococcus equi.
Neutrophils are important in controlling early infections with the intracellular bacterium Rhodococcus equi. Antineutrophil monoclonal antibody (RB6-8C5)-induced neutrophil deficiency during the first week after experimental infection of mice with R. equi resulted in more severe disease and significantly increased tissue concentrations of R. equi.
Martens
Ronald J
RJ
Equine Infectious Disease Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, 77843, USA. rmartens@cvm.tamu.edu
Cohen
Noah D
ND
Jones
Samuel L
SL
Moore
Thomas A
TA
Edwards
John F
JF
D000193:Actinomycetales Infections / Q000276:immunology* / Q000382:microbiology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D016929:Rhodococcus equi / Q000302:isolation & purification; D013154:Spleen / Q000382:microbiology
D000911:Antibodies, Monoclonal