title: Is Cronkhite-Canada Syndrome necessarily a late-onset disease?
abstract: Cronkhite-Canada Syndrome is a non-inherited, non-congenital disease characterized by juvenile hamartomatous gastrointestinal polyps with a typically late onset. In the case described herein the disease was diagnosed in a 17-year-old male with type I diabetes and thalassaemia minor, in coincidence with severe symptomatic intestinal candidiasis. Following the disappearance of the mycosis and correction of the protein and electrolyte imbalance, the ectodermal abnormalities returned to normal and the patient remained asymptomatic during a 7-year follow-up period, despite proteinuria resulting from membranous glomerulopathy. The concept that Cronkhite-Canada Syndrome is a late-onset disease should probably be reconsidered as it may remain asymptomatic, and thus not diagnosed, for a long a time.
authors.affiliation: Gastroenterology Unit, Department of Clinical Science, University of Rome La Sapienza, Rome, Italy. vernia@uniroma1.it
authors.forename: Piero
authors.initials: P
authors.lastname: Vernia
authors.forename: Adriana
authors.initials: A
authors.lastname: Marcheggiano
authors.forename: Vanessa
authors.initials: V
authors.lastname: Marinaro
authors.forename: Santo
authors.initials: S
authors.lastname: Morabito
authors.forename: Isabella
authors.initials: I
authors.lastname: Guzzo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pierucci
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002177:Candidiasis / Q000150:complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D015433:Glomerulonephritis, Membranous / Q000150:complications; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D013577:Syndrome; D017086:beta-Thalassemia / Q000150:complications