title: Primary and secondary prevention of chronic kidney disease.
abstract: The incidence and prevalence of chronic kidney disease (CKD) is on the rise worldwide. End-stage renal disease (ESRD) is the most advanced form of CKD, requiring some form of renal replacement therapy to ensure survival. Interventions to prevent or slow the progression of CKD, irrespective of the original cause, are thus of significant importance. The most effective of these interventions is based on the inhibition of the renin-angiotensin system (RAS) and is the main focus of this review.
authors.affiliation: Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Kambiz
authors.initials: K
authors.lastname: Zandi-Nejad
authors.forename: Barry M
authors.initials: BM
authors.lastname: Brenner
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000517:prevention & control; D012084:Renin-Angiotensin System / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors