Increased prevalence of gestational diabetes mellitus in in vitro fertilization pregnancies inadvertently conceived during treatment with long-acting triptorelin acetate.
Thirty-five pregnancies were inadvertently conceived during the midluteal application of the long-acting gonadotropin-releasing hormone agonist triptorelin acetate before ovarian stimulation for in vitro fertilization. Most of the conceptions occurred before the first or second IVF trial, and were associated with a significantly increased tendency to develop gestational diabetes. No increase in pregnancy wastage or appearance of congenital malformations occurred.
Mayer
Amit
A
Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Lunenfeld
Eitan
E
Wiznitzer
Arnon
A
Har-Vardi
Iris
I
Bentov
Yacov
Y
Levitas
Eliahu
E
D000328:Adult; D003692:Delayed-Action Preparations; D016640:Diabetes, Gestational / Q000139:chemically induced* / Q000453:epidemiology*; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000706:statistics & numerical data*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D015995:Prevalence; D017329:Triptorelin Pamoate / Q000008:administration & dosage* / Q000009:adverse effects
D003692:Delayed-Action Preparations; D017329:Triptorelin Pamoate