title: Simultaneous bilateral spontaneous pneumothorax observed during the administration of gefitinib for lung adenocarcinoma with multiple lung metastases.
abstract: A 41-year-old man with productive cough was admitted to our hospital. His chest roentgenogram showed multiple small nodules in the bilateral lung fields. The nodules were revealed as intrapulmonary metastases of the adenocarcinoma of the lung. Systemic chemotherapy with paclitaxel and carboplatin was not effective, and continuous oral gefitinib therapy was initiated. Twenty-one days later, spontaneous pneumothorax was found in the left lung, and four days after that, in the right lung as well. The extent of the pneumothorax was slight; therefore, he recovered without drainage within several days. Spontaneous pneumothorax, especially bilateral pneumothorax, is a rare complication of chemotherapy for lung cancer.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Mori
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Takeya
authors.initials: T
authors.lastname: Fujikawa
authors.forename: Takeo
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kawamura
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Namba
authors.forename: Manabu
authors.initials: M
authors.lastname: Niinaka
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takeda
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kimura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Naka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okada
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yokota
authors.forename: Masami
authors.initials: M
authors.lastname: Ito
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000284:Administration, Oral; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D011030:Pneumothorax / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011799:Quinazolines / Q000008:administration & dosage / Q000009:adverse effects*; D011859:Radiography
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D000077156:Gefitinib