Protective effect of albumin on lungs injury in traumatic/hemorrhagic shock rats.
OBJECTIVE
To determine the effect of albumin administration on lung injury in traumatic/hemorrhagic shock (T/HS) rats.


METHODS
Forty-eight adult Sprague-Dawley rats were divided into three groups randomly (n=16 in each group): Group A, Group B, Group C. In Group A, rats underwent laparotomy without shock. In Group B, rats undergoing T/HS were resuscitated with their blood plus lactated Ringer's (twice the volume of shed blood). In Group C, rats undergoing T/HS were resuscitated with their shed blood plus additional 3 ml of 5% human albumin. The expression of polymorphonuclear neutrophils CD18/CD11b in jugular vein blood was evaluated. The main lung injury indexes (the activity of myeloperoxidase and lung injury score) were measured.


RESULTS
Significant differences of the expression of CD18/11b and the severity degree of lung injury were founded between the three groups. (P<0.05). The expression of CD18/CD11b and the main lung injury indexes in Group B and Group C increased significantly compared with those in Group A (P<0.05). At the same time, the expression of CD18/CD11b and the main lung injury indexes in Group C decreased dramatically, compared those in Group B (P<0.05).


CONCLUSIONS
The infusion of albumin during resuscitation period can protect lungs from injury and decrease the expression of CD18/CD11b in T/HS rats.
Ding
Chen-yan
CY
The Department of Emergency Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Chen
Zuo-bing
ZB
Zheng
Shu-sen
SS
Gao
Yuan
Y
Zhang
Yun
Y
Zhao
Xue-hong
XH
Ni
Ling-mei
LM
D000418:Albumins / Q000627:therapeutic use*; D000818:Animals; D039481:CD11b Antigen / Q000378:metabolism; D018821:CD18 Antigens / Q000378:metabolism; D004195:Disease Models, Animal; D009504:Neutrophils / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000378:metabolism; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications* / Q000378:metabolism
D000418:Albumins; D039481:CD11b Antigen; D018821:CD18 Antigens