title: Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.
abstract: Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.
authors.affiliation: Hôpital Gui de Chauliac, Montpellier, France. a-crespel@chu-montpellier.fr
authors.forename: A
authors.initials: A
authors.lastname: Crespel
authors.forename: P
authors.initials: P
authors.lastname: Genton
authors.forename: M
authors.initials: M
authors.lastname: Berramdane
authors.forename: P
authors.initials: P
authors.lastname: Coubes
authors.forename: C
authors.initials: C
authors.lastname: Monicard
authors.forename: M
authors.initials: M
authors.lastname: Baldy-Moulinier
authors.forename: P
authors.initials: P
authors.lastname: Gelisse
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000503:physiopathology; D004831:Epilepsies, Myoclonic / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced* / Q000503:physiopathology; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects*; D014635:Valproic Acid / Q000009:adverse effects
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine