Autologous fibrin glue in peripheral nerve regeneration in vivo.
The activity of several growth factors on peripheral nerve regeneration is reported. Autologous fibrin glue contains a large number of platelets, which release significant quantities of growth factors. In order to understand the role of autologous fibrin glue in peripheral nerve regeneration, a 15-mm rabbit peroneal nerve defect was repaired using a vein graft filled with autologous fibrin glue. Axonal regeneration was examined using histological and electrophysiological methods. The extent of axonal regeneration was superior when treated with autologous fibrin glue. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in autologous fibrin glue, might effectively promote peripheral nerve regeneration in nerve defects.
Choi
Byung-Ho
BH
Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, (Brain Korea 21 Project for Medical Sciences) Seoul, South Korea. choibh@wonju.yon-sei.ac.kr
Han
Sang-Gyun
SG
Kim
Sung-Hoon
SH
Zhu
Shi-Jiang
SJ
Huh
Jin-Young
JY
Jung
Jae-Hyung
JH
Lee
Seoung-Ho
SH
Kim
Byung-Yong
BY
D000818:Animals; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D007601:Jugular Veins / Q000637:transplantation*; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects*; D009431:Neural Conduction / Q000502:physiology; D010543:Peroneal Nerve / Q000503:physiopathology*; D020427:Peroneal Neuropathies / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D011817:Rabbits; D020127:Recovery of Function / Q000502:physiology; D014014:Tissue Adhesives / Q000494:pharmacology*
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives