[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].
Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine. Hyperactivity of xanthineoxidase and POL content were also revealed. The close correlation relation of purine indices of such patients has been observed. The obtained data allow applying methods of correction of immunity system and purine metabolism to these patients by introducing in a complex therapy inhibitors of xanthineoxidase.
Nikolenko
Iu I
IuI
Siniachenko
O V
OV
Anan'eva
M N
MN
Nikolenko
V Iu
VIu
Dubiaga
V V
VV
Shchukin
I N
IN
D000596:Amino Acids / Q000097:blood* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000378:metabolism*; D006073:Gout / Q000097:blood / Q000150:complications / Q000378:metabolism*; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D008054:Lipid Peroxides / Q000097:blood; D011687:Purines / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
D000596:Amino Acids; D008054:Lipid Peroxides; D011687:Purines; D014527:Uric Acid; D014969:Xanthine Oxidase; C030985:purine