title: Physiological activity of irradiated green tea polyphenol on the human skin.
abstract: Physiological activity of irradiated green tea polyphenol on the human skin was investigated for further industrial application. The green tea polyphenol was separated and irradiated at 40 kGy by y-ray. For an anti-wrinkle effect, the collagenase inhibition effect was higher in the irradiated sample (65.3%) than that of the non-irradiated control (56.8%) at 200 ppm of the concentration (p < 0.05). Collagen biosynthesis rates using a human fibroblast were 19.4% and 16.3% in the irradiated and the non-irradiated polyphenols, respectively. The tyrosinase inhibition effect, which is related to the skin-whitening effect, showed a 45.2% and 42.9% in the irradiated and the non-irradiated polyphenols, respectively, at a 100 ppm level. A higher than 90% growth inhibition on skin cancer cells (SK-MEL-2 and G361) was demonstrated in both the irradiated and the non-irradiated polyphenols. Thus, the irradiation of green tea polyphenol did not change and even increased its anti-wrinkle, skin-whitening and anticancer effects on the human skin. The results indicated that irradiated green tea polyphenol can be used as a natural ingredient with excellent physiological functions for the human skin through cosmetic or food composition.
authors.affiliation: Department of Cosmeceutical Science, Daegu Haany University, Kyungsan 712-715, South Korea. anbj@dhu.ac.kr
authors.forename: Bong-Jeun
authors.initials: BJ
authors.lastname: An
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Kwak
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Son
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Park
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Tae Soon
authors.initials: TS
authors.lastname: Park
authors.forename: So-Yeun
authors.initials: SY
authors.lastname: Kim
authors.forename: Yeoung-Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Cheorun
authors.initials: C
authors.lastname: Jo
authors.forename: Myung-Woo
authors.initials: MW
authors.lastname: Byun
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism; D003358:Cosmetics; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D005514:Food Irradiation; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D008545:Melanoma / Q000188:drug therapy*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D012867:Skin / Q000166:cytology; D015595:Skin Aging / Q000187:drug effects*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013662:Tea
chemical_list: D000970:Antineoplastic Agents; D003358:Cosmetics; D005419:Flavonoids; D061965:Matrix Metalloproteinase Inhibitors; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D003094:Collagen; D014442:Monophenol Monooxygenase