Role of protein modifications mediated by transglutaminase 2 in human viral diseases.
Transglutaminase 2 (TG2) belongs to a family of calcium-dependent enzymes that catalyze transamidation reaction, producing polymerized, polyaminated or deamidated proteins. Recently, a growing number of viral proteins as well as cellular proteins with which they interact have been found to be modified by TG2, suggesting a novel function for TG2 in viral pathogenesis. This review summarizes the results of relevant research, examines the mechanisms underlying TG2 function in host-virus interactions and proposes a model for viral pathogenesis involving TG2.
Jeon
Ju-Hong
JH
Department of Biochemistry and Molecular Biology, Aging and Apoptosis Research Center, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110-799, Korea.
Kim
In-Gyu
IG
D000818:Animals; D002118:Calcium / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress; D011485:Protein Binding; D011487:Protein Conformation; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011499:Protein Processing, Post-Translational; D011503:Transglutaminases / Q000378:metabolism / Q000502:physiology*; D014777:Virus Diseases / Q000201:enzymology*
D003432:Cross-Linking Reagents; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins; D002118:Calcium