title: Application of triazine "superactive esters" in the repetitive synthesis of oligopeptides. Part 2. Synthesis of N-terminal hexapeptide of emerimicin III.
abstract: N-terminal fragment of emerimicin III has been synthesized by the repetitive method in solution, involving triazine ,,superactive esters". The synthetic protocol, equivalent to the classic REMA procedure, has been applied in the step by step approach, and in the fragment coupling affording all the peptide bonds. By monitoring the progress of the synthesis by FAB-MS, 1H-NMR and HPLC, the structure and high purity of the final products have been confirmed.
authors.affiliation: Institute of Organic Chemistry, Technical University of Lódź, 116 Zeromskiego Str., 90-924 Lódź, Poland.
authors.forename: Zbigniew J
authors.initials: ZJ
authors.lastname: Kamiński
authors.forename: Bashar
authors.initials: B
authors.lastname: Saleh
authors.forename: Beata
authors.initials: B
authors.lastname: Kolesińiska
authors.forename: Adam
authors.initials: A
authors.lastname: Redliński
authors.forename: Juliusz
authors.initials: J
authors.lastname: Rudziński
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis*; D054848:Peptaibols; D010455:Peptides / Q000032:analysis / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004952:Esters; D009842:Oligopeptides; D054848:Peptaibols; D010455:Peptides; D014227:Triazines