title: Use of long-term microdialysis subcutaneous glucose monitoring in the management of neonatal diabetes. A first case report.
abstract: In neonatal diabetes mellitus (NDM), a rare genetic disorder, insulin therapy is required but the management is difficult. Frequent blood glucose determinations are necessary in most cases. Microdialysis subcutaneous glucose monitoring (MSGM) is feasible in neonates and has been proposed to reduce painful blood sampling and blood loss. We have applied long-term MSGM to a small-for-date female newborn with transient NDM. We found a good correlation of subcutaneous and blood glucose concentration over a wide range of values. MSGM enabled a reduction in blood glucose determinations during optimization of intravenous insulin treatment and initiation of continuous subcutaneous insulin infusion. We conclude that long-term MSGM is feasible and may reduce painful blood sampling and blood loss in NDM. Furthermore, long-term MSGM may hold a potential for avoiding hypoglycemic episodes and earlier discharge.
authors.affiliation: Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Germany. andreas.holzinger@med.uni-muenchen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Holzinger
authors.forename: Walter
authors.initials: W
authors.lastname: Bonfig
authors.forename: Beate
authors.initials: B
authors.lastname: Kusser
authors.forename: Thomas
authors.initials: T
authors.lastname: Eggermann
authors.forename: Herbert
authors.initials: H
authors.lastname: Müller
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Munch
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D005947:Glucose / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007328:Insulin / Q000008:administration & dosage; D017551:Microdialysis; D018895:Microsatellite Repeats
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose