title: Apolipoprotein E epsilon4 allele and neurobehavioral status after on-pump coronary artery bypass grafting.
abstract: Abstract Background and Aim: The presence of apolipoprotein E epsilon4 allele is being considered as a risk factor for cognitive decline after cardiac surgery. We sought the effect of apolipoprotein E epsilon4 allele on neurobehavioral status after on-pump coronary artery bypass grafting.
  
  
  METHODS
  Prior to the operation, neurologic examination and neurobehavioral cognitive status test (COGNISTAT) were performed. Both procedures were repeated on the day of discharge and 3 months after surgery. Apolipoprotein E epsilon4 allele positive and apolipoprotein E epsilon4 allele negative patients' performance on COGNISTAT were compared.
  
  
  RESULTS
  There was no statistically significant demographic and operative data difference between two groups. No neurological impairment was observed on examinations. There was no statistically significant neurocognitive decline difference between two groups' postoperative performances.
  
  
  CONCLUSIONS
  It seems that apolipoprotein E epsilon4 allele may not affect neurobehavioral status in the intermediate period after on-pump coronary artery bypass grafting.
authors.affiliation: Department of Anesthesiology and Intensive Care, Medical Faculty, Ege University, Izmir, Turkey. askar@med.ege.edu.tr
authors.forename: Fatma Zekiye
authors.initials: FZ
authors.lastname: Askar
authors.forename: Hasan Yurday
authors.initials: HY
authors.lastname: Cetin
authors.forename: Emre
authors.initials: E
authors.lastname: Kumral
authors.forename: Ozgul
authors.initials: O
authors.lastname: Cetin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Acarer
authors.forename: Buket
authors.initials: B
authors.lastname: Kosova
authors.forename: Tahir
authors.initials: T
authors.lastname: Yagdi
mesh_terms: D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood*; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D001026:Coronary Artery Bypass / Q000009:adverse effects; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E