title: Rationale for the potential use of calcitonin in osteoarthritis.
abstract: This review provides evidence that osteoarthritis (OA) or a major subset of OA is not only a disease of cartilage but also a disorder of subchondral bone. This review also discusses the potential efficacy of a bone and cartilage active agent, calcitonin, and discusses how calcitonin might be useful in the pharmaceutical treatment of OA.
authors.affiliation: Department of Rheumatology, University Hospital St Luc, Universite Catholique de Louvain, Brussels, Belgium.
authors.forename: D H
authors.initials: DH
authors.lastname: Manicourt
authors.forename: J P
authors.initials: JP
authors.lastname: Devogelaer
authors.forename: M
authors.initials: M
authors.lastname: Azria
authors.forename: S
authors.initials: S
authors.lastname: Silverman
mesh_terms: D050071:Bone Density Conservation Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016723:Bone Remodeling / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects* / Q000503:physiopathology; D002116:Calcitonin / Q000494:pharmacology* / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D007596:Joints / Q000378:metabolism / Q000502:physiology / Q000503:physiopathology; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D013314:Stress, Mechanical; D016474:Weight-Bearing / Q000502:physiology
chemical_list: D050071:Bone Density Conservation Agents; D002116:Calcitonin