Zinc and the diabetic heart.
Zinc (Zn) is an essential mineral that is required for various cellular functions. Its abnormal metabolism is related to certain disorders such as diabetic complications. Oxidative stress has been considered as the major causative factor for diabetic cardiomyopathy. Zn has a critical antioxidant action in protecting the heart from various oxidative stresses. Zn deficiency was found to be a risk factor for cardiac oxidative damage and supplementation with Zn provides a significant prevention of oxidative damage to the heart. Diabetes causes a significant systemic oxidative stress and also often is accompanied by Zn deficiency that increases the susceptibility of the heart to oxidative damage. Therefore, there is a strong rationale to consider the strategy of Zn supplementation to prevent or delay diabetic cardiomyopathy. This short article collects the preliminary evidence, based on our own studies and those by others, for a preventive effect of Zn supplementation on diabetes-induced injury to the heart in animals and under in vitro conditions. Possible mechanisms by which Zn supplementation prevents diabetic heart disease are discussed. They include an antioxidant action of Zn, insulin function and metallothionein induction. In the final section, the future of Zn supplementation for diabetic patients is also briefly discussed. Although Zn supplementation has not been clinically used to prevent diabetic complications, because several issues need to be addressed, the fact that Zn supplementation is being used clinically for other disorders encourages us to explore its direct clinical application for the prevention of diabetic cardiomyopathy.
Song
Ye
Y
Department of Medicine, University of Louisville, 511 South Floyd Street, MDR 533, KY 40202, USA.
Wang
Jianxun
J
Li
Xiao-kun
XK
Cai
Lu
L
D000818:Animals; D000975:Antioxidants; D001692:Biological Transport; D009202:Cardiomyopathies / Q000473:pathology; D002460:Cell Line; D004396:Coloring Agents / Q000494:pharmacology; D048909:Diabetes Complications / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D019587:Dietary Supplements; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008668:Metallothionein / Q000378:metabolism; D009569:Nitric Oxide / Q000494:pharmacology; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000378:metabolism; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
D000975:Antioxidants; D004396:Coloring Agents; D017382:Reactive Oxygen Species; D013778:Tetrazolium Salts; D013844:Thiazoles; D014280:Triglycerides; D009569:Nitric Oxide; D008668:Metallothionein; D005979:Glutathione Peroxidase; D052250:Nitric Oxide Synthase Type III; D013482:Superoxide Dismutase; C022616:thiazolyl blue; D005978:Glutathione; D015032:Zinc