Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction.
[reaction: see text] A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.
Wang
Jian
J
Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.
Li
Hao
H
Yu
Xinhong
X
Zu
Liansuo
L
Wang
Wei
W
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
D000447:Aldehydes; D000588:Amines; D009281:Naphthalenes; D013890:Thiourea