Aseptic meningitis after intrathecal baclofen injection.
METHODS
Two case reports of aseptic meningitis after intrathecal baclofen injection.


OBJECTIVE
To report an unusual complication of intrathecal baclofen injection during test injections.


METHODS
Department of Neurological Rehabilitation, R Poincaré Hôpital (Paris-Ile de France-Ouest University).


METHODS
We present two cases of chemical meningitis after intrathecal baclofen injections by lumbar puncture. These cases presented with febrile meningeal syndromes during the 24 h following intrathecal baclofen injection. Direct cerebrospinal fluid (CSF) examination and CSF cultures were negative. An intense cellular reaction was observed with a marked predominance of neutrophils. Meningitis resolved spontaneously over 3-4 days.


CONCLUSIONS
Chemical meningitis is a rare complication of intrathecal baclofen injections that must be recognized. It is a diagnosis of exclusion and its pathophysiological mechanism remains unclear.
Bensmail
D
D
Service de Médecine Physique et Réadaptation, Hôpital R Poincaré, Garches, France.
Peskine
A
A
Denys
P
P
Bernard
L
L
Bussel
B
B
D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D005260:Female; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D008582:Meningitis, Aseptic / Q000188:drug therapy*; D008875:Middle Aged
D018755:GABA Agonists; D001418:Baclofen