[Serious clinical course of myocarditis with "apical ballooning": first presentation of pathogenicity of HHV6 subtype A in myocarditis].
We report of a 67 year-old female who has suffered a flu-like infection three days ago and presented with symptoms of acute coronary syndrome. Coronary heart disease could be excluded. The ventriculography showed a moderate reduced left ventricular function characterized by "apical ballooning". Endomyocardial biopsies and EDTA blood gave a direct proof of human herpes virus 6 subtype A. Histological and immunohistochemical analysis revealed a myocarditis with areas of interstitial macrophages and fibrosis. This case presents for the first time the cross-link of myocarditis with HHV6A infection and the appearance of "apical ballooning".
Bigalke
B
B
Medizinische Klinik III, Eberhard-Karls-Universität Tübingen. boris.bigalke@med.uni-tuebingen.de
Klingel
K
K
May
A E
AE
Beyer
M
M
Hövelborn
T
T
Kandolf
R
R
Gawaz
M
M
D000368:Aged; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D009205:Myocarditis / Q000150:complications / Q000175:diagnosis*; D019349:Roseolovirus Infections / Q000150:complications / Q000175:diagnosis*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology