title: Review of photorejuvenation: devices, cosmeceuticals, or both?
abstract: BACKGROUND
  Both the public and the medical profession have placed a lot of attention on reversal of signs of aging and photodamage, resulting in numerous cosmeceutical products and nonablative laser techniques designed to achieve these results.
  
  
  OBJECTIVE
  The purpose of this report is to briefly review both the cosmeceutical products and nonablative laser techniques that appear to be most promising based on published studies. After this review, recommendations for potential enhancement of benefits by combining cosmeceuticals and laser treatments will be explored.
  
  
  RESULTS
  Pulsed dye lasers targeting microvessels, intense pulsed light targeting both melanin and microvessels, and midinfrared lasers targeting dermal water and collagen all appear to have some ability to improve skin texture, color, and wrinkling. Retinoids, vitamin C, alpha-hydroxy acids, and topical growth factors may also stimulate repair mechanisms that result in similar improvements in photodamaged skin.
  
  
  CONCLUSIONS
  Although supported only by theoretic considerations and anecdotal reports, it seems logical that the concurrent use of appropriate cosmeceuticals with nonablative laser photorejuvenation should result in enhanced benefits.
authors.affiliation: Albert Einstein College of Medicine, Bronx, New York, USA. cameron@postharvard.edu
authors.forename: Cameron K
authors.initials: CK
authors.lastname: Rokhsar
authors.forename: Sandra
authors.initials: S
authors.lastname: Lee
authors.forename: Richard E
authors.initials: RE
authors.lastname: Fitzpatrick
mesh_terms: D001205:Ascorbic Acid / Q000627:therapeutic use; D003358:Cosmetics / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D010789:Phototherapy; D012060:Rejuvenation / Q000502:physiology; D015595:Skin Aging / Q000473:pathology / Q000528:radiation effects; D013684:Telangiectasis / Q000628:therapy; D014801:Vitamin A / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D003358:Cosmetics; D014815:Vitamins; D014801:Vitamin A; D001205:Ascorbic Acid