title: C3'-cis-Substituted carboxycyclopropyl glycines as metabotropic glutamate 2/3 receptor agonists: synthesis and SAR studies.
abstract: The synthesis of a series of C3'-cis-substituted carboxycyclopropyl glycines bearing a wide variety of functional groups is described, and the structure-activity relationship for this series as agonists of group II metabotropic glutamate receptors is reported.
authors.affiliation: Lilly, Alcobendas, Madrid, Spain. gonzalez_rosario@lilly.com
authors.forename: Rosario
authors.initials: R
authors.lastname: González
authors.forename: Iván
authors.initials: I
authors.lastname: Collado
authors.forename: Beatriz López
authors.initials: BL
authors.lastname: de Uralde
authors.forename: Alicia
authors.initials: A
authors.lastname: Marcos
authors.forename: Luisa M
authors.initials: LM
authors.lastname: Martín-Cabrejas
authors.forename: Concepción
authors.initials: C
authors.lastname: Pedregal
authors.forename: Jaime
authors.initials: J
authors.lastname: Blanco-Urgoiti
authors.forename: Javier
authors.initials: J
authors.lastname: Pérez-Castells
authors.forename: M Alejandro
authors.initials: MA
authors.lastname: Fernández
authors.forename: Sherri L
authors.initials: SL
authors.lastname: Andis
authors.forename: Bryan G
authors.initials: BG
authors.lastname: Johnson
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Wright
authors.forename: Darryle D
authors.initials: DD
authors.lastname: Schoepp
authors.forename: James A
authors.initials: JA
authors.lastname: Monn
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D005998:Glycine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3; D005998:Glycine