[Experimental study on xue-bao capsules against injury of radiation or cyclophosphamide in mice].
OBJECTIVE
To explore the effects of xue-bao capsules on injury of radio-or chemo-therapy in mice, in order to provide rationale behind clinical trials.


METHODS
xue-xu (deficiency of blood) model in mice was induced by radiation or cyclophosphamide. Leucocyte (WBC), erythrocyte (RBC), hemoglobin (Hb) and platelet (Pt) in peripheral blood as well as CFU-E and CFU-Gm in bone marrow were counted.


RESULTS
CFU-E and CFU-Gm in normal mice were promoted by this drug. The reduction of WBC, RBC and Hb in peripheral blood as well as CFU-E and CFU-Gm in bone marrow owing to the 3.5 Gy of 60Co radiation were antagonized by the drug. It had also antagonized cyclophosphamide induced the reduction of WBC, RBC and Pt in peripheral blood.


CONCLUSIONS
xue-bao capsules has the effects against the adverse reactions of radio-or-chemo-therapy.
Gao
Tian-Hong
TH
Shanxi Provincial Institute for Drug Control, Taiyuan 030001, China. gaotianhong@126.com
Piao
Jin-Hua
JH
Zhang
Li
L
Zhang
Hong
H
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D002214:Capsules; D002452:Cell Count; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000633:toxicity; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004906:Erythrocyte Count; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D042381:Granulocyte Precursor Cells / Q000187:drug effects / Q000528:radiation effects; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D010976:Platelet Count; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000473:pathology*; D011897:Random Allocation; D014916:Whole-Body Irradiation / Q000009:adverse effects
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide