Syphilitic uveitis in patients infected with human immunodeficiency virus.
BACKGROUND
This work investigates the incidence and clinical features of syphilitic uveitis in patients infected with human immunodeficiency virus (HIV).


METHODS
We retrospectively reviewed syphilitic uveitis in patients coinfected with HIV that presented at a referral center between July 2001 and November 2003.


RESULTS
Twelve patients (20 eyes) were included. The ocular manifestations of syphilis led to the discovery of HIV-1 seropositivity in three patients. All patients were male and homosexual. One patient has been previously treated for syphilis with benzathine penicillin G. One patient presented with anterior uveitis and 11 patients had panuveitis or posterior uveitis. Necrotizing retinitis was noted in seven eyes (35%), posterior placoid chorioretinitis in six eyes (30%) and optic nerve involvement in five eyes (25%). Of nine patients with available cerebrospinal fluid (CSF) studies, seven (77.8%) had CSF abnormalities. Eleven patients were treated with intravenous penicillin G and one with intravenous ceftriaxone sodium. One patient required a second course of antibiotics to control uveitis. Ocular inflammation decreased and visual acuity improved in all nine patients for whom follow-up was available after treatment.


CONCLUSIONS
Manifestations of syphilitic uveitis in HIV-infected patients are multiple, with high frequencies of posterior uveitis, posterior placoid chorioretinitis, necrotizing retinitis and optic nerve involvement. Syphilitic uveitis in HIV-infected patients seems to have a more severe course and may relapse despite high-dose intravenous penicillin therapy.
Tran
Thi Ha Chau
TH
Service d'Ophtalmologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Cassoux
Nathalie
N
Bodaghi
Bahram
B
Fardeau
Christine
C
Caumes
Eric
E
Lehoang
Phuc
P
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D002825:Chorioretinitis / Q000209:etiology; D015818:Eye Infections, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D005451:Fluorescein Angiography; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006716:Homosexuality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use; D015882:Retinal Necrosis Syndrome, Acute / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D013587:Syphilis / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D010400:Penicillin G