title: Conservative treatment of temporomandibular joint osteoarthrosis: intra-articular injection of sodium hyaluronate.
abstract: Promising short-term results in the treatment of temporomandibular joint osteoarthrosis with intra-articular injections of sodium hyaluronate (SH) have been reported in preliminary studies. The present prospective study compared long-term outcomes of temporomandibular joint SH injections with those of a conventional non-surgical treatment (bite-plane). Data from three groups of 20 patients with degenerative temporomandibular joint disease were considered. Group A underwent one cycle of five injections of 1 mL SH. Group B underwent a bite-plane treatment for at least 6 months. We considered a control group of 20 patients who refused any treatments. The description of the outcomes was based on objective and subjective parameters after a 6-month follow-up. Sodium hyaluronate and bite-plane treatments significantly improved patients conditions in all considered parameters. No significant differences in outcomes were confirmed by the statistical analysis. The tolerability of SH treatment resulted to be significantly higher. The analysis of results of serial controls in the SH treated group disclosed a significant worsening in pain at rest by comparing 1 and 6 months follow-up. Sodium hyaluronate infiltration resulted a valid non-surgical treatment for temporomandibular joint degenerative disease. Five well-tolerated intra-articular SH injections achieved equivalent results to those of a 6 months bite-plane treatment. We did not diagnose any complications of SH intra-articular injections. Longer time follow-up is necessary to determine the stability of SH properties.
authors.affiliation: Department of Maxillofacial Surgery, University of Padua, Padua, Italy. luca.guarda@unipd.it
authors.forename: L
authors.initials: L
authors.lastname: Guarda-Nardini
authors.forename: S
authors.initials: S
authors.lastname: Masiero
authors.forename: G
authors.initials: G
authors.lastname: Marioni
mesh_terms: D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D007270:Injections, Intra-Articular; D008297:Male; D008409:Mastication / Q000502:physiology; D008875:Middle Aged; D008970:Molecular Weight; D009055:Mouth / Q000503:physiopathology; D009068:Movement / Q000502:physiology; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control; D017060:Patient Satisfaction; D011446:Prospective Studies; D012146:Rest / Q000502:physiology; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D006820:Hyaluronic Acid