title: Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases.
abstract: Peroxisome proliferator activated receptor gamma (PPARgamma) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARgamma agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARgamma agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.
authors.affiliation: Xenotransplantation Center and Cell Death Research Center, Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Byung Ha
authors.initials: BH
authors.lastname: Chung
authors.forename: Sun Woo
authors.initials: SW
authors.lastname: Lim
authors.forename: Kyung Ohk
authors.initials: KO
authors.lastname: Ahn
authors.forename: Akira
authors.initials: A
authors.lastname: Sugawara
authors.forename: Sadayoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Bum Soon
authors.initials: BS
authors.lastname: Choi
authors.forename: Yong Soo
authors.initials: YS
authors.lastname: Kim
authors.forename: Byung Kee
authors.initials: BK
authors.lastname: Bang
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Yang
mesh_terms: D000818:Animals; D019610:Cytoprotection; D003928:Diabetic Nephropathies / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D047495:PPAR gamma / Q000819:agonists*
chemical_list: D047495:PPAR gamma