Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis.
We studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) on apoptosis and differentiation of several cell lines in vitro. We also studied the same effects of fluctuating vs constant concentrations of As2O3 in vivo in patients treated with daily 3-hour fast infusions or daily slow, continuous infusions. Intracellular concentrations of arsenic and apoptosis rate were higher whereas differentiation was reduced in cells exposed to constant concentrations of As2O3.
Zhou
Jin
J
Meng
Ran
R
Sui
Xinhua
X
Meng
Lu
L
Jia
Jianping
J
Yang
Baofeng
B
D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001151:Arsenic / Q000378:metabolism; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage*; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D002460:Cell Line; D004334:Drug Administration Schedule; D006801:Humans; D007424:Intracellular Fluid / Q000187:drug effects* / Q000378:metabolism; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000188:drug therapy* / Q000473:pathology*; D010087:Oxides / Q000008:administration & dosage*
D001152:Arsenicals; D010087:Oxides; D001151:Arsenic; D000077237:Arsenic Trioxide