title: Accuracy of tissue Doppler echocardiography in the emergency diagnosis of decompensated heart failure with preserved left ventricular systolic function: comparison with B-type natriuretic peptide measurement.
abstract: BACKGROUND
  Tissue Doppler echocardiography provides a reliable noninvasive estimation of left ventricular (LV) filling pressures irrespective of LV ejection fraction. However, the diagnostic accuracy of E/Ea ratio has not been adequately determined in patients with suspected heart failure (HF) with preserved LV systolic function in the acute care setting.
  
  
  OBJECTIVE
  To investigate the accuracy of E/Ea ratio in the emergency diagnosis of decompensated HF with preserved LV systolic function.
  
  
  METHODS
  Seventy patients with a LV ejection fraction >or=45%, 32 with decompensated HF (77 +/- 12 years of age), and 38 with noncardiac cause of acute dyspnea (74 +/- 12) were enrolled. B-type natriuretic peptide (BNP) was measured on admission; lateral, septal and average E/Ea ratios were calculated within 24 hours.
  
  
  RESULTS
  Using receiver-operating characteristic curves to evaluate diagnostic performance, BNP (AUC of 0.875, P < 0.0001) and E/Ea ratios (AUC of 0.90-0.92, P < 0.0001) provided similar accuracy for predicting decompensated HF. Optimal cutoffs were 146 pg/ml for BNP (sensitivity and specificity of 90.6% and 76.3%), 9.8 for lateral E/Ea (83.3% and 88.9%), 12.7 for septal E/Ea (76.7% and 91.4%), and 11.5 for average E/Ea ratio (80% and 94.3%). On multivariate logistic regression analysis, average E/Ea ratio yielded independent additional information to a model based on the clinical judgment and BNP level according to the standard cutoff of 100 pg/ml.
  
  
  CONCLUSIONS
  Tissue Doppler echocardiography is accurate for predicting decompensated HF with preserved LV systolic function and may be used as a diagnostic complement to inconclusive BNP level in this setting.
authors.affiliation: Department of Cardiology, Aubagne Hospital, Aubagne, France. sarques@ch-aubagne.rss.fr
authors.forename: Stephane
authors.initials: S
authors.lastname: Arques
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roux
authors.forename: Pascal
authors.initials: P
authors.lastname: Sbragia
authors.forename: Pierre
authors.initials: P
authors.lastname: Ambrosi
authors.forename: Lionel
authors.initials: L
authors.lastname: Taieb
authors.forename: Bertrand
authors.initials: B
authors.lastname: Pieri
authors.forename: Richard
authors.initials: R
authors.lastname: Gelisse
authors.forename: Roger
authors.initials: R
authors.lastname: Luccioni
mesh_terms: D000208:Acute Disease; D000368:Aged; D003422:Critical Care / Q000379:methods*; D004417:Dyspnea / Q000097:blood* / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D020097:Natriuretic Peptide, Brain