Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields.
The incidence of breast cancer in western societies has been rising ever since the Second World War. Besides the exposure to a multitude of new chemical compounds, electromagnetic field exposure has been linked to breast cancer through a radiation-mediated anti-melatonin pathway. We investigated, whether low-frequency electromagnetic field exposure interferes with the anti-estrogenic activity of tamoxifen. Two different clones of the breast cancer cell line MCF-7 were exposed to highly homogeneous 50Hz electromagnetic fields and IC(50) values were calculated from dose-response curves of tamoxifen at various field intensities. An intensity-dependent shift of tamoxifen dose-response curves to higher concentrations with a maximal response at 1.2muT was observed. Hypothetically, electromagnetic field exposure could contribute to tamoxifen resistance observed in breast cancer after long-term treatment.
Girgert
Rainer
R
Department of Obstetrics and Gynecology, University of Göttingen, Germany. rainer.girgert@med.uni-goettingen.de
Schimming
Hartmut
H
Körner
Wolfgang
W
Gründker
Carsten
C
Hanf
Volker
V
D001943:Breast Neoplasms; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects / Q000528:radiation effects; D019008:Drug Resistance, Neoplasm / Q000528:radiation effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000494:pharmacology*
D004965:Estrogen Antagonists; D013629:Tamoxifen