Electrostatic interactions with histone tails may bend linker DNA in chromatin.
Is linker DNA bent in the 30-nm chromatin fiber at physiological conditions? We show here that electrostatic interactions between linker DNA and histone tails including salt condensation and release may bend linker DNA, thus affecting the higher order organization of chromatin.
Perico
Angelo
A
Istituto per lo Studio delle Macromolecole (ISMac), Section of Genova, Italy. perico@ge.ismac.cnr.it
La Penna
Giovanni
G
Arcesi
Luca
L
D002843:Chromatin / Q000502:physiology*; D004247:DNA / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D008961:Models, Structural; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000502:physiology; D055672:Static Electricity; D013816:Thermodynamics
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D004247:DNA