[Analysis of the clinicopathological features of Chinese hereditary nonpolyposis colorectal cancer].
OBJECTIVE
To investigate the clinicopathological features of Chinese hereditary nonpolyposis colorectal cancer (HNPCC).


METHODS
Patients who met the Amsterdam criteria were enrolled in this study from several hospitals in China. Clinicopathological features of patients with HNPCC were compared between the patients with suspected HNPCC and sporadic colorectal cancer.


RESULTS
One hundred and sixty-seven individuals from 31 families met the Amsterdam criteria. The average age was 48.6 (22-78) years old. There were 43 cases (31.9%) with ascending colon cancer and 52 cases (38.5%) with rectal cancer. The 3-, 5-, 10- years survival rate was 70.3%, 49.9% and 39.7% respectively. The incidence of multiple primary neoplasms was 20.4% .


CONCLUSIONS
Chinese HNPCC is characterized by early disease onset. Rectal cancer and ascending colon cancer are the first and the secondly common cancer for Chinese HNPCC. Gastric cancer is the most common parenteral cancer in Chinese HNPCC families.
Jin
Hei-ying
HY
National Center of Colorectal Surgery, The Third Affiliated Hospital, Nanjing University of TCM, Nanjing 210001, China. jinheiying@yahoo.com.cn
Cui
Long
L
Ding
Yi-jiang
YJ
Yan
Yu-ti
YT
Meng
Rong-gui
RG
Liu
Fei
F
Zhang
Xiao-chun
XC
Yu
De-hong
DH
D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult