[Fetal warfarin syndrome in twin pregnancy].
We describe a pair of twins, whose mother was being treated by oral anticoagulant drugs, as a result of having received mitral heart valve implantation in the past. The male twins monochorionic, monoamniotic--but one infant showed the features of fetal warfarin syndrome. In the study we discussed the pharmacogentetics and individual variation in the human metabolism during treatment with warfarin-perinatal growth and prevalence of congenital malformations. We analysed the threats to the fetus and mother, connected with administration of anticoagulant drugs.
Królak-Olejnik
Barbara
B
Katedra i Klinika Perinatologii i Ginckologii w Zabrzu, SIAM, Katowicach. olejnik@pik-net.pl
Pyrkosz
Antoni
A
Lagan
Jerzy
J
Zembala-Nozyńska
Ewa
E
Kaźmierczak
Wojciech
W
D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D004200:Diseases in Twins / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008944:Mitral Valve Insufficiency / Q000188:drug therapy; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D011297:Prenatal Exposure Delayed Effects; D014427:Twins; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects*
D000925:Anticoagulants; D014859:Warfarin