Morphological changes in adrenal cortex--the final effect of angiotensin II receptor antagonists.
The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex. After a 2-month break in drug administration, the reconstruction of glandular cells was noticed, which could indicate that the observed changes are of transitory character.
Masłyk
Teresa
T
Department and Institute of Histology and Embryology, Skubiszewski Medical University of Lublin.
Romanowska-Sarlej
Jadwiga
J
Kifer-Wysocka
Ewa
E
Matysiak
Włodzimierz
W
Czerny
Krystyna
K
D000302:Adrenal Cortex / Q000187:drug effects* / Q000473:pathology; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D019808:Losartan / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D047228:Angiotensin II Type 1 Receptor Blockers; D019808:Losartan