Mechanisms regulating lymphocytic infiltration of the thyroid in murine models of thyroiditis.
The autoimmune diseases of the thyroid are the most prevalent autoimmune diseases in man. In these diseases, the thyroid is invariably infiltrated by lymphocytes, which play a major role in pathogenesis. In this review, we discuss the mechanisms associated with lymphocytic infiltration of the thyroid, examining different models of thyroid autoimmune disease in mice.
Lira
Sergio A
SA
Immunobiology Center, Mount Sinai School of Medicine, Box 1630, New York, NY 10029-6574, USA. sergio.lira@mssm.edu
Martin
Andrea P
AP
Marinkovic
Tatjana
T
Furtado
Glaucia C
GC
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D004195:Disease Models, Animal; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000209:etiology / Q000276:immunology* / Q000473:pathology*