Oral and dental findings in Fanconi's anemia.
Fanconi's anemia is an autosomal recessive disorder characterized by progressive pancytopenia and congenital malformation of the skeleton. This study investigated the oral health status of 15 children with Fanconi's anemia, including oral lesions, gingival and periodontal status, and dental abnormalities. All children in the group were found to have a tendency to develop tooth decay and were in need of dental treatment. Two had aggressive periodontitis. In one patient supernumerary teeth were found, while in another teeth were congenitally missing. The increased tendency toward periodontal disease in patients with Fanconi's anemia may be due not only to the anemia, leukopenia, and defective detoxification of oxygen radicals that are characteristic of the disease itself, but also to medications applied during intense immunosuppressive treatment, such as prednisolone.
Açikgöz
Aydan
A
Baskent University Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Ankara, Turkey.
Ozden
Feyza Otan
FO
Fisgin
Tunç
T
Açikgöz
Gokhan
G
Duru
Feride
F
Yarali
Nese
N
Albayrak
Davut
D
D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000150:complications / Q000000981:diagnostic imaging; D002648:Child; D005199:Fanconi Anemia / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D009056:Mouth Abnormalities / Q000150:complications / Q000000981:diagnostic imaging; D010518:Periodontitis / Q000150:complications / Q000000981:diagnostic imaging; D011859:Radiography