title: Expression of a novel Ski-like gene in Xenopus development.
abstract: Members of the Ski/Sno family of gene products contain a characteristic peptide domain involved in protein-protein or protein-DNA interaction. Here, we characterize the developmental expression of xDawg, in Xenopus laevis, of a new gene, related to the Ski/Sno family of transcription regulators. The Ski/Sno domain of xDawg is predicted to present an electropositive surface, consistent with a role in DNA binding. This gene is expressed in the marginal zone of early gastrulae, and in the brain, sensory vesicles, and cranial neural crest of neurula and tailbud embryos.
authors.affiliation: Center for Molecular and Human Genetics, Columbus Children's Research Institute, 700 Children's Dr., Columbus, OH 43026, USA.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Seufert
authors.forename: Rashmi S
authors.initials: RS
authors.lastname: Hegde
authors.forename: Srivamsi
authors.initials: S
authors.lastname: Nekkalapudi
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Kelly
authors.forename: Heithem M
authors.initials: HM
authors.lastname: El-Hodiri
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004625:Embryo, Nonmammalian / Q000737:chemistry / Q000378:metabolism; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D012261:Ribonucleoproteins / Q000032:analysis / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics*; D029867:Xenopus Proteins / Q000235:genetics*; D014982:Xenopus laevis / Q000196:embryology* / Q000235:genetics
chemical_list: C511874:Dawg protein, Xenopus; D012261:Ribonucleoproteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C026452:messenger ribonucleoprotein