title: Antiinflammatory, analgesic and antiperoxidative efficacy of Barleria lupulina Lindl. extract.
abstract: A study was undertaken to investigate the antiinflammatory efficacy of methanol extract of aerial parts of Barleria lupulina Lindl. [MEBL] (Family: Acanthaceae) in acute and sub-acute inflammation models of albino rats. The MEBL in all the tested dose levels exhibited significant inhibition of carrageenin and serotonin induced paw oedema volumes when compared with the untreated (control) group. The MEBL also exerted a significant reduction in granuloma weight in the cotton pellet induced granuloma model. These potentials were comparable to that of the standard drug (indomethacin). The plant extract was also tested for its analgesic, ulcerogenic and antiperoxidative potential. The extract also demonstrated protection against CCl(4) induced lipid peroxidation and acetic acid induced writhing. Acute administration of MEBL (300 mg/kg) did not produce any gastric lesion in rats.
authors.affiliation: Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Chennai, India. kannamma2k@yahoo.com
authors.forename: V
authors.initials: V
authors.lastname: Suba
authors.forename: T
authors.initials: T
authors.lastname: Murugesan
authors.forename: R
authors.initials: R
authors.lastname: Kumaravelrajan
authors.forename: Subash C
authors.initials: SC
authors.lastname: Mandal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002251:Carbon Tetrachloride; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000188:drug therapy / Q000473:pathology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D002251:Carbon Tetrachloride