TGFbeta-1 and the development of chronic graft nephropathy: relative roles of gene, mRNA and protein.
The exact relationship between transforming growth factor beta-1 (TGFbeta-1) and the development of chronic graft nephropathy remains uncertain; however, it would appear that TGFbeta-1 is up-regulated at the protein and mRNA levels during the first year following cadaveric renal transplantation and the effect of 'high producer' gene polymorphisms may also be important. This up-regulation of TGFbeta-1 in plasma may provide a novel. non-invasive means of identifying early fibrotic damage before it becomes clinically apparent thus allowing an opportunity for intervention for grafts that may otherwise fail.
Morris-Stiff
Gareth
G
Welsh Transplantation Research Group, University of Wales College of Medicine, Heath Park, Cardiff, UK. garethmorrisstiff@hotmail.com
D002908:Chronic Disease; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology*; D053773:Transforming Growth Factor beta1
D012333:RNA, Messenger; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1