title: Incidence of Demodex folliculorum in patients with end stage chronic renal failure.
abstract: BACKGROUND
  Demodex folliculorum (DF), found in the pilosebaceous unit, is the most common ectoparasite in humans. It has been implicated in various clinical lesions such as pustular folliculitis, papulopustular scalp eruption, perioral dermatitis, and skin lesions of immunosuppressed patients on chemotherapy or with acquired immunodeficiency syndrome (AIDS).
  
  
  OBJECTIVE
  We aimed to determine DF carriers and location of DF among patients on chronic dialysis because of end stage renal failure (ESRF), to compare them with healthy controls, and to examine the relationship between DF incidence and dialysis method and symptoms.
  
  
  METHODS
  Sixty-seven patients on dialysis and 67 healthy controls were taken into the study. The patient groups were classified according to the diseases causing ESRF [diabetes mellitus (DM), polycystic disease (PCD), glomerulonephritis (GN), hypertensive nephrosclerosis (HTNS), others (OT), unknown etiology (UE)], and mode of dialysis. Five standardized skin surface biopsies (SSSB) were taken. The determination of five and more living parasites/cm2 area was diagnosed as infestation.
  
  
  RESULTS
  The mean mite count in the ESRF group, 6.12/cm2, was significantly higher than that in controls, 0.31/cm2, (Independent Samples Test, p=0.000). The DF positivity according to primary disease causing ESRF revealed that it was most frequent in DM with 12 patients (44.4%), followed by UE with nine patients (33.4%).
  
  
  CONCLUSIONS
  Our findings indicate that the DF number is increased in ESRF patients on dialysis treatment. We recommend that demodicidosis should be included in the differential diagnosis of facial eruptions in patients with ESRF.
authors.affiliation: Department of Dermatology, School of Medicine, Inonu University, Malatya, Turkey. ykarincaoglu@inonu.edu.tr
authors.forename: Yelda
authors.initials: Y
authors.lastname: Karincaoglu
authors.forename: Muammer
authors.initials: M
authors.lastname: Esrefoglu Seyhan
authors.forename: Nalan
authors.initials: N
authors.lastname: Bayram
authors.forename: Ozlem
authors.initials: O
authors.lastname: Aycan
authors.forename: Hulya
authors.initials: H
authors.lastname: Taskapan
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008924:Mite Infestations / Q000175:diagnosis / Q000453:epidemiology*; D008925:Mites; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D006435:Renal Dialysis / Q000379:methods; D017678:Sex Distribution