A study on ceftriaxone-induced lipid peroxidation using 4-hydroxy-2-nonenal as model marker.
4-Hydroxy-2-nonenal, an indicator of lipid peroxidation process. was used as model marker to explore ceftriaxone-induced lipid peroxidation in goat liver homogenate. Ceftriaxone was found to induce lipid peroxidation significantly. It was further found that ascorbic acid could significantly arrest ceftriaxone-induced lipid peroxidation. The results corroborate the earlier findings with malondialdehyde as model marker.
Chakraborty
Santanu
S
Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032 India.
Bhuti
Pritesh Dev
PD
Ray
Supratim
S
Sengupta
Chandana
C
Roy
Kunal
K
D000447:Aldehydes / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D015415:Biomarkers / Q000378:metabolism; D002443:Ceftriaxone / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D006041:Goats; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D015203:Reproducibility of Results; D013997:Time Factors
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D015415:Biomarkers; D009569:Nitric Oxide; D008315:Malondialdehyde; D002443:Ceftriaxone; D005978:Glutathione; C027576:4-hydroxy-2-nonenal; D001205:Ascorbic Acid