title: [The proper use of carbapenem examined by Monte Carlo simulation].
abstract: Monte Carlo simulation was employed for this comparative study to determine the optimal Carbapenem and its dosing strategy to cure the infections by Escherichia coli and Pseudomonas aeruginosa and to consider how the difference of each Carbapenems in dosing regimens and antibiotic activity influenced to maximize % T > MIC. This result revealed that it was important to increase a dose and a number of doses a day, in addition to great antibiotic activity for maximizing % T > MIC.
authors.affiliation: Division of Anaerobe Research, Life Science Research Center, Gifu University.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
authors.forename: Kyouichi
authors.initials: K
authors.lastname: Totsuka
mesh_terms: D015780:Carbapenems / Q000008:administration & dosage*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D009010:Monte Carlo Method; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa
chemical_list: D015780:Carbapenems