Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar.
The purpose of this study was to evaluate the potential of alendronate sodium (ALN), a biphosohonate to stimulate hard tissue formation in pulpotomized (amputated) rat molars. Two commonly used pulpotomy materials, calcium hydroxide (CH) and formocresol (FC) were utilized for comparisons. Histological evaluations were performed by observers blinded to treatment allocation on days 7, 15, 30 and 60, followed by statistical analysis of selected histological criteria. In all evaluation periods, hard tissue deposition was evident along the radicular dentin in ALN and CH groups. In days 30 and 60, the latter two groups showed no differences in inflammatory cell response and hard tissue deposition scores (P > 0.05). ALN appears to be capable of maintaining pulpal vitality, while promoting hard tissue formation, similar to CH.
Cengiz
S Burcak
SB
Department of Pediatric Dentistry, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. seviburcak@yahoo.com
Batirbaygil
Yildiz
Y
Onur
Mehmet Ali
MA
Atilla
Pergin
P
Asan
Esin
E
Altay
Nil
N
Cehreli
Zafer C
ZC
D019386:Alendronate / Q000494:pharmacology*; D000818:Animals; D001843:Bone Cements / Q000494:pharmacology*; D002126:Calcium Hydroxide / Q000494:pharmacology*; D003804:Dentin / Q000187:drug effects; D005566:Formocresols / Q000494:pharmacology*; D008297:Male; D008963:Molar / Q000187:drug effects*; D011672:Pulpotomy / Q000379:methods; D051381:Rats; D017208:Rats, Wistar
D001843:Bone Cements; D005566:Formocresols; C031025:formocresol; D002126:Calcium Hydroxide; D019386:Alendronate