title: Energy intakes of children with Crohn's disease treated with enteral nutrition as primary therapy.
abstract: BACKGROUND
  Enteral nutrition (EN) is widely used and is effective in the treatment of children with Crohn's disease given as an exclusive feed for 6-8 weeks. Current dietetic practice during EN is to recommend an energy intake based on estimated average requirement (EAR) for energy for age.
  
  
  OBJECTIVE
  To examine factors affecting energy intake and weight gain during EN in relation to disease site and nutritional status.
  
  
  METHODS
  A retrospective cohort study examining energy intake and weight gain during the exclusive EN feeding period in 40 patients newly diagnosed with Crohn's in relation to EAR, nutritional status, disease site.
  
  
  RESULTS
  All patients improved clinically and gained weight during EN with improvement in the CRP as a marker of the systemic inflammatory response. Energy intake was higher than EAR in 82% (33/40 patients), with the median 117.5% of EAR. Weight gain correlated with body mass index standard deviation score (P = 0.001) at start of treatment, but not energy intake or CRP.
  
  
  CONCLUSIONS
  Estimated average requirement underestimates energy intakes in most children with newly diagnosed Crohn's disease. During EN, an energy intake in the range of 100-149% (median 117.5%) EAR for energy for age may be required. Energy balance studies in children with active disease are required.
authors.affiliation: Department of Nutrition and Dietetics, Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton, UK. joangavin@btinternet.com
authors.forename: J
authors.initials: J
authors.lastname: Gavin
authors.forename: C E
authors.initials: CE
authors.lastname: Anderson
authors.forename: A R
authors.initials: AR
authors.lastname: Bremner
authors.forename: R M
authors.initials: RM
authors.lastname: Beattie
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D015331:Cohort Studies; D003424:Crohn Disease / Q000628:therapy*; D002149:Energy Intake / Q000187:drug effects; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D008297:Male; D009751:Nutritional Requirements; D009752:Nutritional Status; D012189:Retrospective Studies; D015430:Weight Gain / Q000187:drug effects
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein