title: Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents.
abstract: A series of 22 compounds were synthesized and screened against Plasmodium falciparum NF-54 strain. Of the screened compounds, 6 compounds showed MIC in the range between 1 and 2 microg/mL. These compounds are 32 times more potent than the cycloguanil which was used as the standard drug.
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Sanjay Babu
authors.initials: SB
authors.lastname: Katiyar
authors.forename: Kumkum
authors.initials: K
authors.lastname: Srivastava
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: Prem M S
authors.initials: PM
authors.lastname: Chauhan
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D011720:Pyrazoles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D011720:Pyrazoles; D014227:Triazines