Antibacterial and antioxidant activity and essential oil composition of Grammosciadium scabridum Boiss. from Iran.
The in vitro antibacterial and antioxidant activity of the essential oil and its two main components of Grammosciadium scabridum Boiss. (Apiaceae) growing wild in Iran, as well as the composition of its essential oil were studied. A total of 19 compounds representing 99.9% of the oil has been identified. Gamma-Terpinene (73.5%), p-cymene (14.2%) and (E)-beta-farnesene (5.3%) were characterized as the main components. The oil showed remarkable activity against three Gram-negative and four Gram-positive test bacteria, with minimal inhibitory concentration (MIC) values ranging from 0.31 to 10.00 mg/ml. The oil and its two main components were also subjected to screening for their possible antioxidant activity by using the 2,2-diphenyl-l-picrylhydrazyl (DPPH) assay. The free radical scavenging capacity of the oil was determined with an IC50 value of 6.6 mg/ml.
Sonboli
Ali
A
Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, P.O. Box 19835-389, Tehran, Iran. a-sonboli@cc.sbu.ac.ir
Salehi
Peyman
P
Kanani
Mohammad Reza
MR
Ebrahimi
Samad Nejad
SN
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D016166:Free Radical Scavengers; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007492:Iran; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D009822:Oils, Volatile