[The role of AP-1 and NF-kappaB in glucocorticoid resistance].
Glucocorticoid exerts its anti-inflammatory effect mainly through the suppression of both AP-1 and NF-kappaB by its receptor, glucocorticoid receptor(GR). AP-1 and NF-kappaB are also supposed to be involved in glucocorticoid resistance. Here we describe the role of AP-1 and NF-kappaB in glucocorticoid resistance.
Okabe
Taijiro
T
Department of Medicine and Bioregulatory Science, Graduate School of Medicine, Kyushu University.
Yanase
Toshihiko
T
Nawada
Hajime
H
D000818:Animals; D004351:Drug Resistance / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D016328:NF-kappa B / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000502:physiology; D018808:Transcription Factor AP-1 / Q000502:physiology*
D005938:Glucocorticoids; D016328:NF-kappa B; D011965:Receptors, Glucocorticoid; D018808:Transcription Factor AP-1