title: Regional changes of fractional anisotropy with normal aging using statistical parametric mapping (SPM).
abstract: OBJECTIVE
  There has been reports on the usefulness of diffusion tensor imaging (DTI) about age-or disease-related degradation. DTI is generally evaluated by the region of interest (ROI) methodology. In this study, we applied a statistical way using Statistical Parametric Mapping (SPM) to assess normal aging by DTI and compared results of these two methods.
  
  
  METHODS
  Ten young and ten senior normal volunteers were examined. On SPM, tensor images were changed into normalized tensor images. They were compared between the two groups by t-test.
  
  
  RESULTS
  In the senior group, fractional anisotropy (FA) values were higher on the basal ganglia, cingulated gyrus and other cortical gray matter, lower in the corona radiata, internal capsule, centrum semiovale and corpus callosum by using SPM. In the ROI method, the results were almost compatible except in the brain periphery.
  
  
  CONCLUSIONS
  Aging changes on water diffusion anisotropy was clearly shown by SPM method which would be useful to evaluate change of water diffusion anisotropy without operator bias even in clinical setting instead of ROI measurement.
authors.affiliation: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Furutani
authors.forename: Masafumi
authors.initials: M
authors.lastname: Harada
authors.forename: Masako
authors.initials: M
authors.lastname: Minato
authors.forename: Naomi
authors.initials: N
authors.lastname: Morita
authors.forename: Hiromu
authors.initials: H
authors.lastname: Nishitani
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D016880:Anisotropy; D001699:Biometry; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged