title: Synthesis of (-)-amphidinolide K fragment C9-C22.
abstract: [reaction: see text] The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (-)-amphidinolide K (1) has been achieved from synthons C9-C14 (3) and C15-C22 (4), which have both been prepared from glutamic acid in good overall yields.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Av. Diagonal 647, Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain.
authors.forename: Thanos
authors.initials: T
authors.lastname: Andreou
authors.forename: Anna M
authors.initials: AM
authors.lastname: Costa
authors.forename: Laia
authors.initials: L
authors.lastname: Esteban
authors.forename: Lluïsa
authors.initials: L
authors.lastname: Gonzàlez
authors.forename: Gemma
authors.initials: G
authors.lastname: Mas
authors.forename: Jaume
authors.initials: J
authors.lastname: Vilarrasa
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; C409107:amphidinolide K; D000097442:Amphidinolides