title: [Magnetic resonance tomography: potentials of molecular imaging].
abstract: Molecular imaging is "the in-vivo characterization and measurement of biological processes at the cellular and molecular level" and allows the imaging of molecular abnormalities associated with diseases long before morphological changes can be detected. At present, the use of magnetic resonance imaging (MRI) for molecular and cellular imaging is rapidly increasing. MRI is a very attractive candidate, since current MRI protocols already provide anatomic, functional, and biochemical information of excellent image quality and with high spatial resolution. Combining this high spatial resolution/high contrast imaging modality with specific MRI contrast imaging agents for molecular imaging is currently the focus of research in many laboratories worldwide. This paper summarizes the rationale for molecular MRI imaging and describes the basic features of modern molecular imaging strategies with MRI. Finally, a special focus is given to the growing field of applications, e.g., stem cell imaging, imaging of apoptosis, plaques, and other biological targets of interest.
authors.affiliation: Lehrstuhl für Experimentelle Physik V, Universität Würzburg, Am Hubland, D-97074 Würzburg. hiller@physik.uni-wuerzburg.de
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Hiller
authors.forename: Cornelius
authors.initials: C
authors.lastname: Faber
authors.forename: Thomas
authors.initials: T
authors.lastname: Neuberger
authors.forename: Sascha
authors.initials: S
authors.lastname: Köhler
authors.forename: Albrecht
authors.initials: A
authors.lastname: Stroh
authors.forename: Claus
authors.initials: C
authors.lastname: Zimmer
authors.forename: Peter
authors.initials: P
authors.lastname: Jakob
mesh_terms: D017209:Apoptosis / Q000502:physiology; D001161:Arteriosclerosis / Q000175:diagnosis; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D013234:Stem Cells / Q000166:cytology
chemical_list: D003287:Contrast Media