title: Pre-biotic stage of life origin under non-photosynthetic conditions.
abstract: Spontaneous assembling of a simplest bacterial cell even if all necessary molecules are present in a solution seems to be extremely rare event and from the scientific standpoint has to be considered as impossible. Therefore, a predecessor of a living cell has to be very simple for providing its self-assembling and at the same time it should be able of progressive increase in complexity. Now phase-separated particles, first of all micelles, are put forward as possible predecessors of living cell. According to the offered working concept only phase-separated particles possessing autocatalytic properties can be considered as predecessors of living cells. The first stage of evolution of these phase-separated autocatalytic systems is the appearance of pre-biotic metabolism providing synthesis of amphiphiles for formation of capsules of these systems. This synthesis is maintained by the energy of a base reaction being a component of a planet-chemical cycle. Catalytic system providing functioning of pre-biotic metabolism is based on multivariate oligomeric autocatalyst, which reproduces itself from monomers, penetrating the particles from the outside. Since the autocatalyst realizes random polymerization then a collection of other oligomers possessing different catalytic functions is produced. In the paper the functioning of multivariate oligomeric autocatalyst in flow reactor is analyzed.
authors.affiliation: Laboratory of Theoretical Biophysics, Institute for Biophysics, Siberian Branch of Russian Academy of Sciences, Academgorodok, Krasnoyarsk, Russia. bartsev@online.ru
authors.forename: S I
authors.initials: SI
authors.lastname: Bartsev
authors.forename: V V
authors.initials: VV
authors.lastname: Mezhevikin
mesh_terms: D002384:Catalysis; D019418:Evolution, Chemical; D018559:Exobiology; D005118:Extraterrestrial Environment; D000069497:Origin of Life