title: Susceptibility to oxygen desaturation during bronchoscopy in elderly patients with pulmonary fibrosis.
abstract: BACKGROUND
  Fiber-optic flexible bronchoscopy (FFB) is a frequently performed procedure for the diagnosis and treatment of pulmonary disorders. However, hypoxemia occasionally occurs during FFB.
  
  
  OBJECTIVE
  We attempted to examine the causes of arterial oxygen desaturation during FFB.
  
  
  METHODS
  We studied 336 patients who underwent FFB without intervention between June 1, 2001 and September 30, 2002. Arterial oxygen saturation (SpO2) was continuously monitored using oximetry with a recording system. We analyzed the relationship between a reduction in SpO2 during FFB and various clinical parameters or background lung diseases.
  
  
  RESULTS
  Of the 336 patients, 73 (22%) had an episode of oxygen desaturation (SpO2 <90% over 10 s). Of patients over 80 years old, 55% had an episode of oxygen desaturation, which was significantly higher than 27% observed in the patients of 80 and less than 80 years old (p < 0.05). Patients with pulmonary fibrosis had a higher risk of desaturation (55%) compared to patients with other complications or patients without any complication (p < 0.05). Multivariable analysis revealed that both age and pulmonary fibrosis were independent predictors of oxygen desaturation. However, the majority of the patients (94%) did not require routine oxygen supplementation.
  
  
  CONCLUSIONS
  Although FFB is safe and does not require oxygen supplementation in most cases, age over 80 years and pulmonary fibrosis are high risk factors for significant oxygen desaturation during FFB.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Shinagawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kinoshita
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ogura
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001999:Bronchoscopy; D005541:Forced Expiratory Volume; D005652:Functional Residual Capacity; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D011658:Pulmonary Fibrosis / Q000097:blood* / Q000175:diagnosis*; D013147:Spirometry
chemical_list: D010100:Oxygen