[Dynamic changes in plasma adrenomedullin levels and effect of enalapril intervention in diabetic rats].
OBJECTIVE
To observe the dynamic changes of plasma adrenomedullin (ADM) levels and the effect of enalapril intervention in diabetic rats.


METHODS
Fifty-two wistar rats were grouped into 1- and 3-month groups (7 each), both including a control and a streptozotocin-induced diabetic group. The 5-month group was divided into control, diabetic and enalapril-treatment diabetic groups (8 each, the last group receiving oral enalapril treatment at the daily dose of 2 mg/kg from the first to the fifth month after diabetes induction). Blood samples were collected from the heart of the rats at the end of 1, 3 and 5 months for determination of plasma ADM concentrations radioimmunoassay.


RESULTS
Plasma ADM levels were significantly higher in diabetic rats than in the corresponding control rats in 1- and 3-month groups. ADM levels in the diabetic rats of 5-month group were significantly decreased in comparison with that of 1- and 3-month groups. In 5-month group, plasma ADM levels of enalapril-treated diabetic rats elevated significantly in comparison with that in the control rats and the diabetic rats without enalapril treatment.


CONCLUSIONS
ADM may play an important role in the pathophysiology of diabetes.
Xu
Chun-sheng
CS
Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Li
Zhi-liang
ZL
Zhang
Hua
H
Yan
Quan-neng
QN
Wu
Hong-chao
HC
Tang
Chao-shu
CS
D053607:Adrenomedullin / Q000097:blood*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D004656:Enalapril / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000806:Angiotensin-Converting Enzyme Inhibitors; D053607:Adrenomedullin; D004656:Enalapril