Adhesion molecules in inflammatory bowel disease: therapeutic implications for gut inflammation.
Mucosal endothelium has become one of the major areas of investigation in gut inflammation. It is now well recognised that it plays an active role in the pathogenesis of both forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, since endothelial cells regulate mucosal immune homeostasis, acting as "gatekeepers", controlling leukocyte accumulation in the interstitial compartment. This process is mediated by leukocyte-endothelial adhesion molecules. This paper reviews the major molecules that mediate leukocyte-endothelial interactions, and summarises the results of the most recent clinical trials targeting adhesion molecules in inflammatory bowel disease.
Danese
S
S
Department of Internal Medicine, Catholic University School of Medicine, L.go Vito 1, 00168 Rome, Italy. sdanese@hotmail.com
Semeraro
S
S
Marini
M
M
Roberto
I
I
Armuzzi
A
A
Papa
A
A
Gasbarrini
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology*; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D039441:Integrin alpha4 / Q000627:therapeutic use; D016023:Integrins / Q000502:physiology*; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D007413:Intestinal Mucosa / Q000166:cytology; D007422:Intestines / Q000166:cytology; D007962:Leukocytes; D008024:Ligands; D000069442:Natalizumab; D051381:Rats; D019087:Selectins / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D007136:Immunoglobulins; D016023:Integrins; D008024:Ligands; D000069442:Natalizumab; D019087:Selectins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D039441:Integrin alpha4