Carboplatin sustained delivery system using injectable microspheres.
A controlled carboplatin delivery system using biodegradable polymer has been used in this study. The purpose was to evaluate the local and systemic effects of injectable, biodegradable microspheres containing carboplatin when injected as aqueous suspension subcutaneously in rats. Biocompatibility and toxicity of empty microspheres and microspheres loaded with carboplatin were evaluated by clinical and histological examination. The diffusion of carboplatin in tissues and time of drug release were evaluated by platinum determination in plasma and tissues over the time. The results of the study suggest that microspheres provide a sustained slow release of carboplatin and that multiple inoculations of microspheres containing drug and no evidence of local or systemic toxicity is found. This device may be useful in the treatment of solid tumours.
Manunta
M L
ML
Department of Surgery, School of Veterinary Medicine, University of Sassari, Sassari, Italy. lmanu@uniss.it
Gavini
E
E
Chessa
G
G
Passino
E S
ES
Careddu
G M
GM
Giua
S
S
Mollica
A
A
Demontis
M P
MP
Leoni
A
A
Muzzetto
P
P
D020341:Absorbable Implants / Q000009:adverse effects; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000633:toxicity; D016190:Carboplatin / Q000008:administration & dosage* / Q000633:toxicity; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D008863:Microspheres; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D016190:Carboplatin