Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry.
Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.
Rijkers
Dirk T S
DT
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands.
van Esse
G Wilma
GW
Merkx
Remco
R
Brouwer
Arwin J
AJ
Jacobs
Hans J F
HJ
Pieters
Roland J
RJ
Liskamp
Rob M J
RM
D001386:Azides / Q000737:chemistry; D003500:Cyclization; D050091:Dendrimers / Q000138:chemical synthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis*; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
D001386:Azides; D050091:Dendrimers; D010455:Peptides; D012997:Solvents