Increased apoptosis in the adult rat liver after a single dose of adriamycin administration.
The purpose of this study was the evaluation of hepatocytes in the adult rat's liver after adriamycin administration in a single dose. The presented above morphological changes, on tissue, cell and ultrastructural level are the evidence of persistent and irreversible damage of liver tissue via adriamycin. Cells damaged in that way waste away. In the present study cell death touched mainly single cells and necrosis was not observed. It is the evidence of apoptosis--the natural death of cells.
Pedrycz
Agnieszka
A
Department of Histology and Embryology with the Laboratory for Experimental Cytology, Skubiszewski Medical University of Lublin.
Wieczorski
Marcin
M
Czerny
Krystyna
K
D000367:Age Factors; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar
D004317:Doxorubicin