title: Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors.
abstract: A series of indole cyclopropylmethylamines were found to be potent serotonin reuptake inhibitors. Nitrile substituents at the 5 and 7 positions of the indole ring gave high affinity for hSERT, and the preferred cyclopropane stereochemistry was determined to be (1S,2S)-trans. The cis-cyclopropanes had 20- to 30-fold less affinity than the trans, and the preferred cis stereochemistry was (1R,2S)-cis. Substitution of the indole N-1 position with methyl or ethyl groups gave a 10- to 30-fold decrease in affinity for hSERT, suggesting either a hydrogen-bonding interaction or limited steric tolerance in the region of the indole nitrogen. Compound (+)-12a demonstrated potent hSERT binding (Ki = 0.18 nM) in vitro and was more than 1000-fold less potent at hDAT, hNET, 5-HT1A, and 5-HT6. In vivo, (+)-12a produced robust, dose-dependent increases in extracellular serotonin in rat frontal cortex typical of a selective serotonin reuptake inhibitor. The maximal response produced by (+)-12a was similar to that of fluoxetine but at an approximately 10-fold lower dose.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492-7660, USA. mattsonr@bms.com
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Mattson
authors.forename: John D
authors.initials: JD
authors.lastname: Catt
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Denhart
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Deskus
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Ditta
authors.forename: Mendi A
authors.initials: MA
authors.lastname: Higgins
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Marcin
authors.forename: Charles P
authors.initials: CP
authors.lastname: Sloan
authors.forename: Brett R
authors.initials: BR
authors.lastname: Beno
authors.forename: Qi
authors.initials: Q
authors.lastname: Gao
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Cunningham
authors.forename: Gail K
authors.initials: GK
authors.lastname: Mattson
authors.forename: Thaddeus F
authors.initials: TF
authors.lastname: Molski
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Taber
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Lodge
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017551:Microdialysis; D008958:Models, Molecular; D008968:Molecular Conformation; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003521:Cyclopropanes; D007211:Indoles; D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D014363:Tryptamines; C502839:2-(5-cyano-1H-indol-3-yl)-1-(N,N-dimethylaminomethyl)cyclopropane