Statins, ventricular arrhythmias and heart rate variability in patients with implantable cardioverter defibrillators and coronary heart disease.
The aim of this study was to evaluate whether the incidence of ventricular arrhythmias and heart rate variability were influenced by statin treatment and lipid levels in patients treated with an implantable cardioverter defibrillator (ICD). Heart rate variability measurements were performed in 86 patients with coronary heart disease and an ICD implant. The number of events with ventricular fibrillation and ventricular tachycardia were recorded during a 12-month period. This study lends little support for an antiarrhythmic effect of statins or any relation between plasma lipids and lipoproteins and malignant ventricular arrhythmias in patients with an ICD.
Riahi
Sam
S
Department of Cardiology, Cardiovascular Research Center, Aalborg Hospital, Arhus University, Aalborg, Denmark. samriahi@dadlnet.dk
Schmidt
Erik Berg
EB
Christensen
Jeppe Hagstrup
JH
Heath
Finn
F
Pedersen
Anders Kirstein
AK
Nielsen
Jens Cosedis
JC
Mølgaard
Henning
H
Toft
Egon
E
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000628:therapy*; D017147:Defibrillators, Implantable; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D014693:Ventricular Fibrillation / Q000628:therapy
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol