title: Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions.
abstract: The human T-cell leukemia/lymphoma virus (HTLV) genome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at its 3' end originally designated pX. To date, we know that this region encodes two essential transcriptional and post-transcriptional positive regulators of viral expression, the Tax and Rex proteins, respectively (reviewed elsewhere in this issue). Here, we will review current knowledge of the functions of three additional proteins encoded in the pX region, p12I, p13II, and p30II.
authors.affiliation: Department of Microbiology, University of Kansas Medical Center, Molecular Genetics, and Immunology, 3025 Wahl Hall West, 3901 Rainbow Boulevard, Kansas City, KS 66160-7420, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Nicot
authors.forename: Robert L
authors.initials: RL
authors.lastname: Harrod
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ciminale
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Franchini
mesh_terms: D000595:Amino Acid Sequence; D016679:Genome, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D008954:Models, Biological; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012323:RNA Processing, Post-Transcriptional; D014158:Transcription, Genetic; D017361:Viral Nonstructural Proteins / Q000235:genetics*
chemical_list: D017361:Viral Nonstructural Proteins