title: Anti-corpus luteum antibody and menstrual irregularity in patients with systemic lupus erythematosus and Hashimoto's thyroiditis.
abstract: The aim of the present study was to verify the presence of anti-corpus luteum antibodies (anti-CoL) in systemic lupus erythematosus (SLE) and Hashimoto's thyroiditis (HT) patients, as well as establish its possible correlation with menstrual and/or hormonal disturbances in both populations and with SLE activity. Forty-six patients with SLE, 31 with HT, four with both SLE and HT, and 36 healthy women were studied. Out of these, seven (15.2%) patients with SLE, three (9.7%) with HT, three (75%) with both pathologies, and none of the healthy controls tested positive for anti-CoL. The presence of anti-CoL was not significantly correlated to menstrual disturbance (P = 0.083), changes in the level of follicle stimulating hormone (P = 1.0), luteinizing hormone (P = 0.284), estradiol (P = 0.316), prolactin (P = 1.0) or SLE activity measured by SLEDAI (P = 0.756) in SLE patients. There were not enough patients testing positive for anti-luteal antibodies among those with HT or both HT and SLE (three from each group) for a statistical analysis. In conclusion, we found no association between anti-CoL and menstrual or hormonal disturbance in patients with SLE. Also anti-CoL was not specific for SLE, and was not found to be a marker of ovarian failure in SLE.
authors.affiliation: Division of Rheumatology, Walter Cantidio University Hospital, Ceará Federal University, Fortaleza/Ceará, Brazil. danicsousa_ce@yahoo.com.br
authors.forename: D
authors.initials: D
authors.lastname: Cabral de Sousa
authors.forename: M M
authors.initials: MM
authors.lastname: das Chagas Medeiros
authors.forename: V S
authors.initials: VS
authors.lastname: Trindade Viana
authors.forename: R M
authors.initials: RM
authors.lastname: Salani Mota
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003338:Corpus Luteum / Q000276:immunology*; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000150:complications; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications; D008599:Menstruation Disturbances / Q000097:blood* / Q000209:etiology; D012720:Severity of Illness Index
chemical_list: D000906:Antibodies; D015415:Biomarkers