title: DNA translocation in inorganic nanotubes.
abstract: Inorganic nanotubes were successfully integrated with microfluidic systems to create nanofluidic devices for single DNA molecule sensing. Inorganic nanotubes are unique in their high aspect ratio and exhibit translocation characteristics in which the DNA is fully stretched. Transient changes of ionic current indicate DNA translocation events. A transition from current decrease to current enhancement during translocation was observed on changing the buffer concentration, suggesting interplay between electrostatic charge and geometric blockage effects. These inorganic nanotube nanofluidic devices represent a new platform for the study of single biomolecule translocation with the potential for integration into nanofluidic circuits.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.forename: Rohit
authors.initials: R
authors.lastname: Karnik
authors.forename: Min
authors.initials: M
authors.lastname: Yue
authors.forename: Deyu
authors.initials: D
authors.lastname: Li
authors.forename: Arun
authors.initials: A
authors.lastname: Majumdar
authors.forename: Peidong
authors.initials: P
authors.lastname: Yang
mesh_terms: D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004563:Electrochemistry; D044085:Microfluidics; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D043942:Nanotubes; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D004247:DNA