title: Fluoride metabolism when added to salt.
abstract: The purpose of this review is to present the general characteristics of the metabolism of fluoride particularly as it occurs when ingested with fluoridated salt. Following the absorption of salt-borne fluoride from the stomach and intestines, its metabolism is identical to that of water-borne fluoride or other vehicles containing ionized fluoride. Because fluoridated salt is almost always ingested with food, however, absorption from the gastrointestinal tract may be delayed or reduced. Reports dealing with this subject have shown that fluoride absorption is delayed and, therefore, peak plasma concentrations are lower than when fluoride is ingested with water. The amount of ingested fluoride that is finally absorbed, however, is not appreciably affected unless the meal is composed mainly of components with high calcium concentrations. In this case, the extent of absorption can be reduced by as much as 50%. Fluoridated salt is also ingested less frequently than fluoridated water. Data are presented to show that the dose size and frequency of ingestion have only minor effects on fluoride retention in the body and on the concentrations in plasma, bone and enamel. Finally, calculations are presented to show that the risk of acute toxicity from fluoridated salt is virtually non-existent.
authors.affiliation: Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912-1129, USA. GWHITFOR@mail.mcg.edu
authors.forename: Gary M
authors.initials: GM
authors.lastname: Whitford
mesh_terms: D000042:Absorption; D001842:Bone and Bones / Q000378:metabolism; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D003743:Dental Enamel / Q000378:metabolism; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D005502:Food; D006801:Humans; D008657:Metabolic Clearance Rate; D017680:Potassium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity
chemical_list: D002327:Cariostatic Agents; D017680:Potassium Compounds; D017673:Sodium Chloride, Dietary; D012969:Sodium Fluoride; C033320:potassium fluoride; D005459:Fluorides