Directing transition from innate to acquired immunity: defining a role for IL-6.
Appropriate control of leukocyte recruitment and activation is a fundamental requirement for competent host defense and resolving inflammation. A pivotal event that defines the successful outcome of any inflammatory event is the transition from innate to acquired immunity. In IL-6 deficiency, this process appears defective, and a series of in vivo studies have documented important roles for IL-6 in both the resolution of innate immunity and the development of acquired immune responses. Within this review, particular attention will be given to the regulatory properties of the soluble IL-6 receptor and how its activity may affect chronic disease progression.
Jones
Simon A
SA
Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom.
D002908:Chronic Disease; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D015850:Interleukin-6 / Q000276:immunology / Q000502:physiology*; D007962:Leukocytes / Q000276:immunology; D019947:Receptors, Interleukin-6 / Q000276:immunology / Q000502:physiology
D015850:Interleukin-6; D019947:Receptors, Interleukin-6