Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.
In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage.
Palomba
Stefano
S
Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it
Orio
Francesco
F
Falbo
Angela
A
Russo
Tiziana
T
Tolino
Achille
A
Zullo
Fulvio
F
D000022:Abortion, Spontaneous / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000706:statistics & numerical data; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D010053:Ovary / Q000187:drug effects; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D011247:Pregnancy; D012189:Retrospective Studies
D017395:Plasminogen Activator Inhibitor 1; D008687:Metformin