Predictive model for assessing cognitive impairment by quantitative electroencephalography.
OBJECTIVE
To assess the utility of quantitative electroencephalographic analysis as an indicator of cognitive impairment, we examined the correlation between Mini-Mental State Examination (MMSE) scores and quantitative electroencephalographic (QEEG) power values in elderly patients and constructed a regression model to predict MMSE scores.


BACKGROUND
Because of the growing number of elderly individuals with cognitive deficits, there is an increasing need for simple and objective methods with which to evaluate cognitive function. Although QEEG is reportedly a useful method for this purpose, few researchers have constructed a QEEG-based model for predicting the degree of cognitive impairment in clinical settings.


METHODS
We evaluated brain function using QEEG in 44 elderly patients with memory complaints and compared the results with their MMSE scores.


RESULTS
In the correlation analysis, no significant correlation was found between MMSE scores and QEEG power values. However, a regression model created using relative QEEG and gender for predicting MMSE scores had an adjusted R2 of 0.471.


CONCLUSIONS
This finding suggests that QEEG analysis may be a useful indicator of cognitive decline in patients with memory complaints.
Onishi
Joji
J
Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8550, Japan. j-onishi@med.nagoya-u.ac.jp
Suzuki
Yusuke
Y
Yoshiko
Kenichi
K
Hibino
Shin
S
Iguchi
Akihisa
A
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis*; D015140:Dementia, Vascular / Q000175:diagnosis / Q000523:psychology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D015233:Models, Statistical; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales