title: Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer.
abstract: OBJECTIVE
  The number of patients under 40 years of age with early-onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early-onset endometrial cancer at a single hospital were analyzed.
  
  
  METHODS
  Seventy-four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent.
  
  
  RESULTS
  The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity (P < 0.001). Pathologically, well-differentiated endometrial carcinoma was significantly more frequent (P = 0.011). The 5-year survival rate was high (98.7%). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower (P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer (P = 0.02), their 5-year survival rate was not significantly lower (100%).
  
  
  CONCLUSIONS
  This study found that these two types of early-onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5-year disease-free survival rate was not significantly lower.
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamagami
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.forename: Kouji
authors.initials: K
authors.lastname: Banno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hirao
authors.forename: Fumio
authors.initials: F
authors.lastname: Kataoka
authors.forename: Akira
authors.initials: A
authors.lastname: Hirasawa
authors.forename: Nao
authors.initials: N
authors.lastname: Suzuki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
authors.forename: Shiro
authors.initials: S
authors.lastname: Nozawa
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D000328:Adult; D017668:Age of Onset; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology