title: Staphylococcus aureus as a risk factor for bloodstream infection in children with postoperative mediastinitis.
abstract: Bloodstream infection (BSI) complicates postoperative mediastinitis in >50% of cases. In this retrospective cohort study from 1995-2003, postoperative mediastinitis caused by Staphylococcus aureus was an independent risk factor for the development of BSI (adjusted odds ratio, 6.4; 95% confidence interval, 1.4-29.3). Postoperative mediastinitis caused by S. aureus has a higher intrinsic risk of being complicated by BSI than mediastinitis caused by other pathogens.
authors.affiliation: Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Samir S
authors.initials: SS
authors.lastname: Shah
authors.forename: Ebbing
authors.initials: E
authors.lastname: Lautenbach
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Long
authors.forename: Sarah
authors.initials: S
authors.lastname: Tabbutt
authors.forename: J William
authors.initials: JW
authors.lastname: Gaynor
authors.forename: Warren B
authors.initials: WB
authors.lastname: Bilker
authors.forename: Louis M
authors.initials: LM
authors.lastname: Bell
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008480:Mediastinitis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D016017:Odds Ratio; D011336:Probability; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents