title: Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia.
abstract: BACKGROUND
  The pathologic substrates of frontotemporal dementia (FTD) are difficult to predict in vivo.
  
  
  OBJECTIVE
  To determine whether different pathologic substrates of FTD have distinct patterns of regional atrophy on magnetic resonance imaging (MRI).
  
  
  METHODS
  Retrospective case study.
  
  
  METHODS
  The Institute of Neurology, University College London, and the Institute of Psychiatry, King's College London. Patients Twenty-one cases of FTD selected on pathologic grounds (9 with ubiquitin-positive [tau- and alpha-synuclein-negative] inclusions [FTD-U], 7 with Pick disease [PiD], and 5 with familial FTD with tau exon 10+16 mutations [tau exon 10+16]) and 20 healthy controls were studied.
  
  
  METHODS
  Patterns of gray matter atrophy in each group as assessed by voxel-based morphometry (VBM) and a blinded visual assessment of each MRI study.
  
  
  RESULTS
  All pathologic substrates were associated with atrophy that involved the inferior and medial temporal and inferior frontal lobes. Additionally, specific VBM signatures were identified for each subgroup: FTD-U was associated with asymmetric (left > right) temporal lobe atrophy, PiD was associated with severe dorsolateral bifrontal atrophy, and tau exon 10+16 was associated with asymmetric (right > left) medial temporal lobe atrophy. The VBM findings were supported by blinded visual assessment.
  
  
  CONCLUSIONS
  These findings suggest that MRI patterns of regional gray matter atrophy constitute signatures of tissue pathology in FTD.
authors.affiliation: Dementia Research Centre, Institute of Neurology, University College London, England.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
authors.forename: Martin N
authors.initials: MN
authors.lastname: Rossor
authors.forename: John M
authors.initials: JM
authors.lastname: Stevens
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.forename: Janice L
authors.initials: JL
authors.lastname: Holton
authors.forename: Safa
authors.initials: S
authors.lastname: Al-Sarraj
authors.forename: Alison K
authors.initials: AK
authors.lastname: Godbolt
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.forename: Jason D
authors.initials: JD
authors.lastname: Warren
mesh_terms: D001284:Atrophy / Q000473:pathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003704:Dementia / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology* / Q000503:physiopathology; D018709:Statistics, Nonparametric