Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infection.
The value of West Nile virus immunoglobulin G avidity for distinguishing recent from past infection was investigated using 348 follow-up specimens from 170 viremic blood donors. Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection.
Prince
Harry E
HE
Focus Diagnostics, Cypress, CA 90630, USA. hprince@focusdx.com
Lapé-Nixon
Mary
M
Busch
Michael P
MP
Tobler
Leslie H
LH
Foster
Gregory A
GA
Stramer
Susan L
SL
D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000915:Antibody Affinity; D001782:Blood Donors; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D014766:Viremia / Q000097:blood / Q000276:immunology*; D014901:West Nile Fever / Q000175:diagnosis* / Q000276:immunology*; D014902:West Nile virus / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G