Phenyl radicals react with dinucleoside phosphates by addition to purine bases and H-atom abstraction from a sugar moiety.
Laser-induced acoustic desorption combined with mass spectrometry has been used to demonstrate that phenyl radicals can attack dinucleoside phosphates at both the sugar and base moieties, that purine bases are more susceptible to the attack than pyrimidine bases, and that the more electrophilic the radical, the more efficient the damage to dinucleoside phosphates.
Liu
Ji-ang
JA
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2038, USA.
Petzold
Christopher J
CJ
Ramirez-Arizmendi
Luis E
LE
Perez
James
J
Kenttämaa
Hilkka
H
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D015226:Dinucleoside Phosphates / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D005609:Free Radicals / Q000737:chemistry; D007834:Lasers; D013058:Mass Spectrometry; D015394:Molecular Structure; D011685:Purine Nucleotides / Q000737:chemistry* / Q000528:radiation effects; D011687:Purines / Q000737:chemistry* / Q000528:radiation effects
D001555:Benzene Derivatives; D015226:Dinucleoside Phosphates; D005609:Free Radicals; D011685:Purine Nucleotides; D011687:Purines