title: Conformations of laulimalide in DMSO-d6.
abstract: Laulimalide is one of the newest naturally occurring macrolides known to act as a microtubule stabilizing agent with properties similar to Taxol. It also stands as being one of the most flexible with 18 rotatable bonds. This large number of rotatable bonds allows for approximately 3(18) potential conformers. To examine the conformational energy surface of laulimalide, we have performed an NAMFIS deconvolution analysis for laulimalide in DMSO-d6. The latter has been supplemented with a post-NAMFIS energy analysis at the Becke3LYP/6-31G level that examines the opposing effects of internal hydrogen bonding and syn-pentane interactions. In this way, we have identified 15 laulimalide conformations that can be classified into 5 different families: Supine, Convex, Cobra, Stretch, and Concave motifs.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
authors.forename: Pahk
authors.initials: P
authors.lastname: Thepchatri
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Cicero
authors.forename: Edith
authors.initials: E
authors.lastname: Monteagudo
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Ben
authors.initials: B
authors.lastname: Cornett
authors.forename: Eric R
authors.initials: ER
authors.lastname: Weeks
authors.forename: James P
authors.initials: JP
authors.lastname: Snyder
mesh_terms: D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D018942:Macrolides; D008958:Models, Molecular; D008968:Molecular Conformation; D043823:Taxoids / Q000737:chemistry*
chemical_list: D018942:Macrolides; D043823:Taxoids; C117305:laulimalide; D004121:Dimethyl Sulfoxide