Advances in understanding bone cancer pain.
Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.
Goblirsch
M J
MJ
University of Minnesota, Minneapolis, Minnesota, USA.
Zwolak
P
P
Clohisy
D R
DR
D000818:Animals; D001859:Bone Neoplasms / Q000150:complications* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D009448:Neurochemistry; D010146:Pain / Q000150:complications* / Q000503:physiopathology*; D059408:Pain Management