title: Hidden Markov modelling of spike propagation from interictal MEG data.
abstract: For patients with partial epilepsy, automatic spike detection techniques applied to interictal MEG data often discover several potentially epileptogenic brain regions. An important determination in treatment planning is which of these detected regions are most likely to be the primary sources of epileptogenic activity. Analysis of the patterns of propagation activity between the detected regions may allow for detection of these primary epileptic foci. We describe the use of hidden Markov models (HMM) for estimation of the propagation patterns between several spiking regions from interictal MEG data. Analysis of the estimated transition probability matrix allows us to make inferences regarding the propagation pattern of the abnormal activity and determine the most likely region of its origin. The proposed HMM paradigm allows for a simple incorporation of the spike detector specificity and sensitivity characteristics. We develop bounds on performance for the case of perfect detection. We also apply the technique to simulated data sets in order to study the robustness of the method to the non-ideal specificity-sensitivity characteristics of the event detectors and compare results with the lower bounds. Our study demonstrates robustness of the proposed technique to event detection errors. We conclude with an example of the application of this method to a single patient.
authors.affiliation: Source Signal Imaging Inc., San Diego, CA 92103, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ossadtchi
authors.forename: J C
authors.initials: JC
authors.lastname: Mosher
authors.forename: W W
authors.initials: WW
authors.lastname: Sutherling
authors.forename: R E
authors.initials: RE
authors.lastname: Greenblatt
authors.forename: R M
authors.initials: RM
authors.lastname: Leahy
mesh_terms: D000200:Action Potentials; D001931:Brain Mapping; D004828:Epilepsies, Partial / Q000503:physiopathology*; D006801:Humans; D015225:Magnetoencephalography; D008390:Markov Chains; D008959:Models, Neurological; D012815:Signal Processing, Computer-Assisted