title: Facile synthesis of highly functionalized N-methyl amino acid esters without side-chain protection.
abstract: [reaction: see text] The facile, two-pot synthesis of N-methyl amino acid esters by way of reductive amination is presented. Side chain protection schemes are not required, the starting materials are all commercially available, and the synthetic method is straightforward and affords desired product in very high yield.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.
authors.forename: Kimberly N
authors.initials: KN
authors.lastname: White
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Konopelski
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D000596:Amino Acids; D004952:Esters