title: Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity.
abstract: The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.
authors.affiliation: Department of Chemistry, Syracuse University, CST 1-014, Syracuse, New York 13244-4100, USA.
authors.forename: Corey R
authors.initials: CR
authors.lastname: Centerwall
authors.forename: Jerry
authors.initials: J
authors.lastname: Goodisman
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Kerwood
authors.forename: James C
authors.initials: JC
authors.lastname: Dabrowiak
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002254:Carbonates / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D002254:Carbonates; D002945:Cisplatin