title: Anti-ribosomal P antibodies are associated with nephritis, vascular thrombosis and lymphocytopenia in patients with systemic lupus erythematosus.
abstract: In the present study, anti-ribosomal P antibody in sera of patients with systemic lupus erythematosus was assayed using an enzyme-linked immunosorbent assay, and its association with clinical symptoms of the patients was analyzed. The presence of anti-ribosomal P antibody was associated with increased frequency of lupus nephritis in the presence of anti-DNA antibody, and was associated with increased frequency of vascular thrombosis in the presence of anti-beta2 glycoprotein I antibody and/or lupus anticoagulant. The level of anti-ribosomal P antibody correlated inversely with the peripheral lymphocyte counts.
authors.affiliation: Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama, 963-8558, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Takeda
authors.forename: Haruyo
authors.initials: H
authors.lastname: Iwadate
authors.forename: Kota
authors.initials: K
authors.lastname: Sugisaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Syoji
authors.initials: S
authors.lastname: Nogae
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanno
authors.forename: Reiji
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008181:Lupus Nephritis / Q000453:epidemiology / Q000276:immunology*; D008231:Lymphopenia / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*; D013927:Thrombosis / Q000453:epidemiology / Q000276:immunology*; D053482:beta 2-Glycoprotein I
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006023:Glycoproteins; D012269:Ribosomal Proteins; D053482:beta 2-Glycoprotein I