title: The bone marrow vascular niche: home of HSC differentiation and mobilization.
abstract: The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.
authors.affiliation: Weill Medical College of Cornell University, New York, New York, USA.
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Kopp
authors.forename: Scott T
authors.initials: ST
authors.lastname: Avecilla
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Hooper
authors.forename: Shahin
authors.initials: S
authors.lastname: Rafii
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000502:physiology; D001853:Bone Marrow / Q000098:blood supply*; D002454:Cell Differentiation; D002465:Cell Movement; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D018919:Neovascularization, Physiologic / Q000502:physiology