title: [Study the effects of flavonoids of Rhizoma Drynariae on gene level of rats without ovaries by technology of cDNA array].
abstract: OBJECTIVE
  To study the effects of flavonoids of Rhizoma Drynariae on gene level of rats without ovaries (OP) by technology of cDNA array.
  
  
  METHODS
  The models of rats without ovaries were made After. 24 weeks of treatment, put them to death and sampled 6 ml blood from the abdominal aorta and 4cm spinal cord. Take out the total RNA, then separate the mRNA to check.
  
  
  RESULTS
  There is 70 genes difference between the blank control group and model group, 9 genes difference between the blank control group and flavonoids of Rhizoma Drynariae group. The genes over expression of OP rats models regain normal after the models were fed on flavonoids of Rhizoma Drynariae. There are no differences in the spinal cords genes in the cDNA array analysis of this trail.
  
  
  CONCLUSIONS
  The genes over expression of OP rats models regain normal after the models were fed on flavonoids of Rhizoma Drynariae for 6 months. The result shows that the flavonoids of Rhizoma Drynariae does have certain effects on the gene expression of rats without ovaries.
authors.affiliation: Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091, China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Xie
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Qin
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Chen
authors.forename: Tian-Hong
authors.initials: TH
authors.lastname: Cui
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D020411:Oligonucleotide Array Sequence Analysis; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D029621:Polypodiaceae / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005419:Flavonoids