Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging.
Microwave-based thermoacoustic tomography (TAT) and laser-based photoacoustic tomography (PAT) in a circular scanning configuration were both developed to image deeply seated lesions and objects in biological tissues. Because malignant breast tissue absorbs microwaves more strongly than benign breast tissue, cancers were imaged with good spatial resolution and contrast by TAT in human breast mastectomy specimens. Based on the intrinsic optical contrast between blood and chicken breast muscle, an embedded blood object that was 5 cm deep in the tissue was also detected using PAT at a wavelength of 1064 nm.
Ku
Geng
G
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, TX 77843-3120, USA.
Fornage
Bruno D
BD
Jin
Xing
X
Xu
Minghua
M
Hunt
Kelly K
KK
Wang
Lihong V
LV
D000465:Algorithms; D000818:Animals; D002645:Chickens; D055590:Electromagnetic Phenomena; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008872:Microwaves; D018482:Muscle, Skeletal / Q000166:cytology; D019047:Phantoms, Imaging; D014463:Ultrasonography