title: Safety and efficacy of misoprostol for induction of labour in a semi-urban hospital setting.
abstract: Most studies on the use of misoprostol for induction of labour have been carried out in well-endowed hospitals in developed countries with state-of-the-art monitoring equipment. There is need for more studies to be conducted in facilities with limited resources, if more patients are to benefit from the low cost and effectiveness of the drug. Following Ethical Committee approval, 152 women had labour induced in our maternity unit using intravaginal misoprostol. The patients were monitored clinically using the WHO model partograph with digital palpation of uterine contractions and intermittent auscultation of fetal heart with a pinard stethoscope. One hundred and thirty-five (88.8%) of the women had a vaginal delivery, while nine (5.9%) had a caesarean section for various obstetric indications. Eight cases of uterine hyperstimulation were noted but none of uterine rupture. We conclude that misoprostol can be used safely for induction of labour in less endowed hospital settings such as in developing countries, using basic clinical tools for monitoring.
authors.affiliation: Department of Obstetrics and Gynaecology, Federal Medical Centre, Owo, Ondo State, Nigeria. bisiloto@yahoo.co.uk
authors.forename: O M
authors.initials: OM
authors.lastname: Loto
authors.forename: A A
authors.initials: AA
authors.lastname: Fadahunsi
authors.forename: C O
authors.initials: CO
authors.lastname: Kolade
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D036861:Delivery, Obstetric; D003906:Developing Countries; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006761:Hospitals; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects*; D009549:Nigeria; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects; D010298:Parity; D011247:Pregnancy
chemical_list: D010120:Oxytocics; D016595:Misoprostol