Anti-ribosomal P antibodies are associated with nephritis, vascular thrombosis and lymphocytopenia in patients with systemic lupus erythematosus.
In the present study, anti-ribosomal P antibody in sera of patients with systemic lupus erythematosus was assayed using an enzyme-linked immunosorbent assay, and its association with clinical symptoms of the patients was analyzed. The presence of anti-ribosomal P antibody was associated with increased frequency of lupus nephritis in the presence of anti-DNA antibody, and was associated with increased frequency of vascular thrombosis in the presence of anti-beta2 glycoprotein I antibody and/or lupus anticoagulant. The level of anti-ribosomal P antibody correlated inversely with the peripheral lymphocyte counts.
Takeda
Isao
I
Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama, 963-8558, Japan.
Iwadate
Haruyo
H
Sugisaki
Kota
K
Takahashi
Atsushi
A
Nogae
Syoji
S
Kanno
Takashi
T
Kasukawa
Reiji
R
D000974:Antibodies, Antinuclear / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008181:Lupus Nephritis / Q000453:epidemiology / Q000276:immunology*; D008231:Lymphopenia / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*; D013927:Thrombosis / Q000453:epidemiology / Q000276:immunology*; D053482:beta 2-Glycoprotein I
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006023:Glycoproteins; D012269:Ribosomal Proteins; D053482:beta 2-Glycoprotein I