title: Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.
abstract: Lipomannans (LM) from various mycobacterial species were found to induce expression and secretion of the matrix metalloproteinase 9 (MMP-9) both in human macrophage-like differentiated THP-1 cells and in primary human macrophages. Inhibition studies using antireceptor-neutralizing antibodies are indicative of a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent signaling mechanism. Moreover, LM was shown to down-regulate transcription of the metalloproteinase inhibitor TIMP-1, a major endogenous MMP-9 regulator.
authors.affiliation: Unité de Glycobiologie Structurale et Fonctionnelle, UMR CNRS no. 8576, IFR 118, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France. elisabeth.elass@univ-lille1.fr
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Elass
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Aubry
authors.forename: Maryse
authors.initials: M
authors.lastname: Masson
authors.forename: Agnès
authors.initials: A
authors.lastname: Denys
authors.forename: Yann
authors.initials: Y
authors.lastname: Guérardel
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Maes
authors.forename: Dominique
authors.initials: D
authors.lastname: Legrand
authors.forename: Joël
authors.initials: J
authors.lastname: Mazurier
authors.forename: Laurent
authors.initials: L
authors.lastname: Kremer
mesh_terms: D000906:Antibodies / Q000494:pharmacology; D002478:Cells, Cultured; D015536:Down-Regulation; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D009161:Mycobacterium / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000906:Antibodies; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D019715:Tissue Inhibitor of Metalloproteinase-1; C064351:lipomannan; D020780:Matrix Metalloproteinase 9