title: Physiological range of mechanical synchronicity of the human heart: comparison between different echocardiographic assessment modalities.
abstract: Tissue Doppler was performed to assess physiological ranges of mechanical synchronicity in 47 patients aged 38 to 81 y with normal coronary angiograms, ECG recordings and echocardiographic findings. Maximal time delays between two different left ventricular (LV) walls in long axis time-to-peak tissue displacement (TD_D), respectively in time-to-peak strain (TD_S), time-to-peak strain rate (TD_SR), time-to-peak systolic (TD_VS) and early diastolic (TD_VE) velocities of basal and midwall segments were determined as values corrected for heart rate in a 16-segment LV model and in the right ventricle (RV). Strain (TD_S: LV = 212 +/- 108 ms, RV = 195 +/- 15 ms) and strain rate (TD_SR: LV = 183 +/- 67 ms, RV = 120 +/- 60 ms) showed the highest dyssynchrony values (TD_D: LV = 110 +/- 96 ms, RV = 42 +/- 38 ms; TD_VS: LV = 82 +/- 47 ms, RV = 36 +/- 36 ms; TD_VE: LV = 73 +/- 36 ms, RV = 46 +/- 20 ms) in both ventricles. There was no significant association between a certain LV wall and the occurrence of the earliest, respectively latest peak values of any parameter.
authors.affiliation: Department of Medicine, University Hospital of Mannheim, Mannheim, Germany. poerner@t-online.de
authors.forename: Tudor C
authors.initials: TC
authors.lastname: Poerner
authors.forename: Björn
authors.initials: B
authors.lastname: Goebel
authors.forename: Tobias
authors.initials: T
authors.lastname: Geiger
authors.forename: Dariusch
authors.initials: D
authors.lastname: Haghi
authors.forename: Martin
authors.initials: M
authors.lastname: Borggrefe
authors.forename: Karl K
authors.initials: KK
authors.lastname: Haase
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015150:Echocardiography, Doppler / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D011446:Prospective Studies; D013314:Stress, Mechanical; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*