A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study.
HLA-matched UC blood-derived multipotent stem cells were directly transplanted into the injured spinal cord site of a 37-year-old female patient suffering from spinal cord injury (SPI). In this case, human cord blood (UCB)-derived multipotent stem cells improved sensory perception and movement in the SPI patient's hips and thighs within 41 days of cell transplantation. CT and MRI results also showed regeneration of the spinal cord at the injured site and some of the cauda equina below it. Therefore, it is suggested that UCB multipotent stem cell transplantation could be a good treatment method for SPI patients.
Kang
K-S
KS
Laboratory of Stem Cell and Tumor Biology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Kim
S W
SW
Oh
Y H
YH
Yu
J W
JW
Kim
K-Y
KY
Park
H K
HK
Song
C-H
CH
Han
H
H
D000328:Adult; D002454:Cell Differentiation; D005260:Female; D005312:Fetal Blood; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009068:Movement / Q000502:physiology*; D039902:Multipotent Stem Cells / Q000166:cytology; D009475:Neurons, Afferent / Q000166:cytology / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D033581:Stem Cell Transplantation