title: Correlation between middle cerebral artery peak systolic velocity and fetal hemoglobin after 2 previous intrauterine transfusions.
abstract: OBJECTIVE
  The middle cerebral artery peak systolic velocity (MCA-PSV) has been successfully used for timing the first 2 transfusions in fetuses at risk for anemia because of maternal red cell alloimmunization. The objective of this study was to assess whether the correlation between the MCA-PSV and fetal hemoglobin is maintained in fetuses that had undergone 2 previous intrauterine transfusions.
  
  
  METHODS
  Doppler measurement of MCA-PSV was performed before cordocentesis in 39 fetuses. The timing of the third transfusion was based on traditional criteria. The values of MCA-PSV and hemoglobin were expressed as multiples of the median (MoM). Anemia was defined as mild (hemoglobin <0.84 MoM for a given gestational age, moderate (hemoglobin <0.65 MoM), and severe (hemoglobin <0.55 MoM). Regression analysis was used to assess the correlation between the MCA-PSV MoM and fetal hemoglobin MoM.
  
  
  RESULTS
  Gestational age at Doppler study ranged from 22 to 35 weeks. Six fetuses (15%) had normal hemoglobin concentration; 21 (53%) had mild anemia; 7 (20%) had moderate anemia; and 5 (12%) had severe anemia. There was a linear correlation between fetal hemoglobin (y) and the MCA-PSV (x): y = 1.185 - 0.341x.
  
  
  CONCLUSIONS
  Previously, concerns have been expressed about the accuracy of Doppler prediction of anemia after previous transfusions. Our data suggest that there is a good correlation between the MCA-PSV and fetal hemoglobin in fetuses that have undergone 2 previous transfusions. Our findings expand the clinical situation in which Doppler can be used to monitor red cell alloimmunized pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI, USA. gmari@med.wayne.edu
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Mari
authors.forename: Roland
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Moise
authors.forename: Russell L
authors.initials: RL
authors.lastname: Deter
mesh_terms: D000740:Anemia / Q000517:prevention & control; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control; D005319:Fetal Hemoglobin / Q000032:analysis*; D005865:Gestational Age; D006801:Humans; D020768:Middle Cerebral Artery / Q000502:physiology*; D011247:Pregnancy; D012039:Regional Blood Flow; D019233:Retreatment; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D018608:Ultrasonography, Doppler
chemical_list: D005319:Fetal Hemoglobin