[Effect of the polymorphism of the angiotensin-converting enzyme gene on the plasma angiotensin II levels and the risk of chronic heart failure].
OBJECTIVE
To investigate the effect of the polymorphism of angiotensin-converting enzyme (ACE) gene D/I on the plasma angiotensin II levels and the risk of chronic heart failure.


METHODS
The genotype was determined by polymerase chain reaction (PCR) in 181 subjects (102 controls and 79 patients with chronic heart failure). The levels of plasma Ang II were also assessed by radio-immunity assay (RIA) in the above subjects.


RESULTS
A marked difference in the plasma Ang II levels was observed among the 3 genotypes (DD, ID and II). The levels of plasma Ang II in DD genotype class were the highest [DD: (65.43+/-26.68), ID: (55.49+/-25.90), II: (46.69+/-23.00); P <0.05, DD vs ID; P <0.01, DD vs II]. The ACE gene I/D polymorphism showed that the levels of Ang I were still affected by the ACE genotype after correcting confounding multifactor by linear regression analysis. There was no difference in genotypes or allele frequencies between the patients and the controls in our study.


CONCLUSIONS
The polymorphism of ACE gene D/I is associated with higher plasma Ang II levels in the Chinese. No evidence supports an association between ACE genotype and the diagnosis of chronic heart failure.
Huang
Wen-Yan
WY
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Sun
Ming
M
Zhou
Hong-Yan
HY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D000804:Angiotensin II / Q000097:blood*; D005260:Female; D005838:Genotype; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A