[Studies on paclitaxel-loaded methoxy poly (ethylene glycol)/poly (L-lactic acid) diblock copolymer nanoparticles].
Paclitaxel-loaded methoxy poly (ethylene glycol )-b-poly (L-lactic acid) diblock copolymer nanoparticles (PMT) were prepared by a self-emulsification/solvent evaporation method. The PMT morphology, size and its distribution, and drug release in vitro were investigated by DLS, UV, TEM and HPLC. The results indicate that PMT show a spherical morphology with inner core and outer shell. The diameter (nm) of PMT increases with the increase of the drug-loaded amount. The initial burst release is not observed, the drug releasing rate in vitro is lower, and the accumulated release increases with the increase of replacement amout of the pH7. 4 medium. This study develops a new formulation for paclitaxel and provides an experimental basis for the intravenous administration of paclitaxel.
Deng
Liandong
L
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Sun
Duoxian
D
Zhang
Yueting
Y
Huo
Jianzhong
J
Yuan
Yingjin
Y
Dong
Anjie
A
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D007275:Injections, Intravenous; D053758:Nanoparticles; D017239:Paclitaxel / Q000008:administration & dosage*; D011091:Polyesters / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; C492425:methoxy poly(ethylene glycol)-poly(lactide); D011092:Polyethylene Glycols; D017239:Paclitaxel