title: The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. II. Biological activities.
abstract: The novel gluconeogenesis inhibitor FR225654, isolated from the culture broth of Phoma sp. No. 00144, has an unique structure that consists of a highly oxygenated trans-decalin ring and a beta-keto-enol, with a characteristic side chain. This compound selectively inhibited gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in several in vivo mouse models.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd. yoshihiro.ohtsu@jp.astellas.com
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohtsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sasamura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005943:Gluconeogenesis / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D001786:Blood Glucose; C504133:FR225654; D007004:Hypoglycemic Agents; D009281:Naphthalenes