title: Some current issues in breast cancer screening.
abstract: Randomized trials of mammography have demonstrated the efficacy of mammographic screening for breast cancer in terms of preventing deaths, but various issues of particular interest remain, including: quantification of overdiagnosis; evaluation of service screening outside the research setting; absolute benefit in terms of number needed to screen per life saved; which types of tumours benefit most from early detection; use of screening data to investigate tumour biology and natural history. This paper describes examples of approaches to the above issues, along with some important results.
authors.affiliation: Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London EC1M 6BQ, UK. stephen.duffy@cancer.org.uk
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Duffy
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008403:Mass Screening / Q000379:methods* / Q000639:trends; D008875:Middle Aged; D008962:Models, Theoretical; D009361:Neoplasm Invasiveness; D012107:Research Design; D012306:Risk; D013997:Time Factors