title: Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model.
abstract: In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4(+) T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.
authors.affiliation: Department of Epidemiology and Immunology, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Trzcinski
authors.forename: Claudette
authors.initials: C
authors.lastname: Thompson
authors.forename: Richard
authors.initials: R
authors.lastname: Malley
authors.forename: Marc
authors.initials: M
authors.lastname: Lipsitch
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009666:Nose / Q000382:microbiology; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000254:growth & development / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial