The use of riboflavin and metalloporphyrins in cytochrome P-450 content in Wistar rats.
Phototherapy is commonly used for the treatment of neonatal jaundice. Riboflavin is a photosensitizer that generates singlet oxygen, which promotes bilirubin photodecomposition. Metalloporphyrins are also effective photosensitizers. The effect of a combined dosing regimen of riboflavin and metalloporphyrins was studied, with the aim of increasing the efficiency of the phototherapeutic treatment of hyperbilirubinemia. It was envisaged that riboflavin and the metalloporphyrins, by promoting the photodecomposition of bilirubin, would thereby lead to a reduction of the toxic side effects associated with phototherapy. The results shows that a phototherapeutic treatment, in which riboflavin and metalloporphyrins were co-administered, was effective in reducing Heme Oxygenase activity. However, a comprehensive study of the possible side effects of metalloporphyrin treatment in the wavelength under consideration is essential prior to utilizing these compounds for any clinical applications.
Jain
Ritu
R
Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.
Tiwari
Manisha
M
Chandra
Ramesh
R
Prakash
Gunjhan Upadhyaya Satya
GU
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000188:drug therapy* / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008665:Metalloporphyrins / Q000008:administration & dosage*; D010778:Photochemotherapy / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012256:Riboflavin / Q000008:administration & dosage*
D008665:Metalloporphyrins; D003577:Cytochrome P-450 Enzyme System; D012256:Riboflavin