title: Closer to the source: notch and the nature of thymus-settling cells.
abstract: Questions regarding T cell development have recently received much attention, but the earliest intrathymic differentiation steps in adult mice have remained controversial. Three new papers together show that for at least some thymus-settling precursors, the loss of B lineage potential occurs in the thymus, and Notch acts on multipotent progenitors early after thymic entry.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Valerie P
authors.initials: VP
authors.lastname: Zediak
authors.forename: Ivan
authors.initials: I
authors.lastname: Maillard
authors.forename: Avinash
authors.initials: A
authors.lastname: Bhandoola
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology / Q000276:immunology*; D051880:Receptors, Notch; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
chemical_list: D008565:Membrane Proteins; D051880:Receptors, Notch