title: Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis.
abstract: OBJECTIVE
  To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.
  
  
  METHODS
  A total of 140 atrophic body gastritis patients, diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori (H pylori) antibodies. Gastritis was assessed according to Sydney System.
  
  
  RESULTS
  Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216, P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.
  
  
  CONCLUSIONS
  The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG.
authors.affiliation: Department of Digestive and Liver Disease, University La Sapienza, Ospedale Sant'Andrea, Via di Grottarossa 1035, Roma 00189, Italy. bruno.annibale@uniroma1.it
authors.forename: Bruno
authors.initials: B
authors.lastname: Annibale
authors.forename: Edith
authors.initials: E
authors.lastname: Lahner
authors.forename: Riccardo
authors.initials: R
authors.lastname: Negrini
authors.forename: Flavia
authors.initials: F
authors.lastname: Baccini
authors.forename: Cesare
authors.initials: C
authors.lastname: Bordi
authors.forename: Bruno
authors.initials: B
authors.lastname: Monarca
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Delle Fave
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers; D001706:Biopsy; D005260:Female; D005757:Gastritis, Atrophic / Q000453:epidemiology* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
chemical_list: D001323:Autoantibodies; D015415:Biomarkers