Pathophysiological manifestations in mice exposed to anthrax lethal toxin.
Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.
Culley
Nathan C
NC
Lab Animal Resources, University of Kansas Medical Center, Kansas City, 66160, USA. nculley@kumc.edu
Pinson
David M
DM
Chakrabarty
Anuradha
A
Mayo
Matthew S
MS
LeVine
Steven M
SM
D000818:Animals; D000881:Anthrax / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D000942:Antigens, Bacterial / Q000633:toxicity*; D001427:Bacterial Toxins / Q000633:toxicity*; D001808:Blood Vessels / Q000503:physiopathology; D001980:Bronchi / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000382:microbiology* / Q000503:physiopathology; D005340:Fibrinogen / Q000032:analysis; D006470:Hemorrhage / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009206:Myocardium / Q000737:chemistry / Q000473:pathology
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; C030325:anthrax toxin; D005340:Fibrinogen