title: Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases.
abstract: OBJECTIVE
  Adenocarcinoma ex pleomorphic adenoma is a rare tumor, and thus the management of the tumor has not been established.
  
  
  METHODS
  The retrospective review of the clinical records at Okayama University was performed.
  
  
  RESULTS
  We present five cases of adenocarcinoma ex pleomorphic adenoma of the head and neck, including a rare case with nasopharyngeal adenocarcinoma ex pleomorphic adenoma. There was no response to chemotherapy with nedaplatin and 5-FU, but the nasopharyngeal adenocarcinoma ex pleomorphic adenoma showed a remarkable regression after the administration of docetaxel.
  
  
  CONCLUSIONS
  The combination therapy that includes docetaxel may be a promising treatment for adenocarcinoma ex pleomorphic adenoma of the head and neck.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Okayama 700-8558, Japan. skariya@cc.okayama-u.ac.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Kariya
authors.forename: Michiya
authors.initials: M
authors.lastname: Kosaka
authors.forename: Yorihisa
authors.initials: Y
authors.lastname: Orita
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akagi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nishizaki
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010159:Palate / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology; D012189:Retrospective Studies; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; C053989:nedaplatin; D005472:Fluorouracil