title: Chiral ligand exchange micellar electrokinetic chromatography using borate anion as a central ion.
abstract: Three compounds having 1,2-diol structure (1-phenyl-1,2-ethanediol, 3-phenoxy-1,2-propanediol, and 3-benzyloxy-1,2-propanediol) were enantioseparated by ligand exchange MEKC using (5S)-pinanediol (SPD) as a chiral selector and borate anion as a central ion together with SDS. When (S)-1,2-propanediol, (S)-1,2,4-butanetriol, or (S)-3-tert-butylamino-1,2-propanediol were used as the chiral ligand instead of SPD, these three compounds were not enantioseparated. When borate was replaced with 2-aminoethane-1-sulfonate or N-cyclohexyl-3-aminopropanesulfonate, no chiral separation was achieved. Therefore, the hydrophobic interaction between the chiral selector and the chiral analytes within the transient diastereomeric complex may play an important role in the enantioseparation achieved by the proposed method.
authors.affiliation: Toyama Institute of Health, Kosugi-machi, Toyama, Japan. shuji.kodama@pref.toyama.lg.jp
authors.forename: Shuji
authors.initials: S
authors.lastname: Kodama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Reiko
authors.initials: R
authors.lastname: Iio
authors.forename: Sen-Ichi
authors.initials: S
authors.lastname: Aizawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nakagomi
authors.forename: Kazuichi
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D001881:Borates; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D013237:Stereoisomerism
chemical_list: D001881:Borates; D008024:Ligands