Reversal of hypogonadotropic hypogonadism with tamoxifen in a patient with hyperprolactinemia resistant to dopamine agonists.
OBJECTIVE
To determine the response to tamoxifen in a woman with hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonist drugs.


METHODS
Case report.


METHODS
Academic fertility center.


METHODS
A young woman with persistent amenorrhea, symptomatic hypogonadotropic hypogonadism, and hyperprolactinemia.


METHODS
Tamoxifen was administered in addition to bromocriptine.


METHODS
Measurements of follicle-stimulating hormone, estradiol, prolactin, and progesterone.


RESULTS
Recovery of gonadal-hypothalamic-pituitary axis.


CONCLUSIONS
Tamoxifen can revert the effects of chronic hypogonadotropic hypogonadism induced by hyperprolactinemia resistant to dopamine agonists.
López
José M
JM
Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. jmlopez@med.puc.cl
Oestreicher
Eveline
E
D000328:Adult; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000188:drug therapy*; D007006:Hypogonadism / Q000097:blood / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D013629:Tamoxifen / Q000627:therapeutic use*
D018491:Dopamine Agonists; D013629:Tamoxifen; D011388:Prolactin