title: Anti-ulcer actions of phytosphingosine hydrochloride in different experimental rat ulcer models.
abstract: The gastroprotective activity of phytosphingosine hydrochloride (PS-HCl, CAS 554-62-1) was assessed in four different rat models of experimentally induced gastric ulcer. Various doses (2.5-10 mg/kg) of PS-HCI were orally administered to rats 30 min before the treatment with HCl/ethanol, indometacin, cysteamine, or to rats with ligated pylorus. Oral administration of PS-HCl (2.5-10 mg/kg) to rats prevented the acute ulcer formation in 4 different types of ulcer in a dose-dependent manner as follows: (1) HCl/ethanol-induced gastric mucosal membrane lesions (20.1-47.8% inhibition), (2) indometacin-induced gastric mucosal membrane lesions (4.6-31.9% inhibition), (3) duodenal ulcer induced by cysteamine (10-20% inhibition), (4) gastric secretion and ulceration following pylorus ligation (33.3-61.9% inhibition). These results indicate that PS-HCI may be useful for the prevention of gastric ulcer.
authors.affiliation: Laboratory of Biochemical Engineering, Department of Chemical Engineering, Sung kyun kwan University, Suwon, Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Baek
authors.forename: Nam Ki
authors.initials: NK
authors.lastname: Kim
authors.forename: Hwan-Jun
authors.initials: HJ
authors.lastname: Jin
authors.forename: Chang-Woong
authors.initials: CW
authors.lastname: Koh
authors.forename: Chul Kyung
authors.initials: CK
authors.lastname: Kim
authors.forename: O-Hyep
authors.initials: OH
authors.lastname: Kwon
authors.forename: Jun-Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Myung-Haing
authors.initials: MH
authors.lastname: Cho
authors.forename: Chan-Koo
authors.initials: CK
authors.lastname: Park
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology; D006851:Hydrochloric Acid; D008026:Ligation; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D011453:Prostaglandins; D000431:Ethanol; D003543:Cysteamine; C012491:phytosphingosine; D013110:Sphingosine; D006851:Hydrochloric Acid