title: Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders.
abstract: The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through the induction/activation of regulatory T cells (Tr). The possibility to generate tolerogenic DCs opens new therapeutic perspectives in autoimmune/inflammatory diseases. Therefore, the characterization of the endogenous factors that contribute to the development of tolerogenic DCs is highly relevant. In this study, we report on the use of the known immunosuppressive neuropeptide, the vasoactive intestinal peptide, as a new approach to induce tolerogenic DCs with capacity to generate Tr cells, to restore tolerance in vivo, and to reduce the progression of rheumatoid arthritis and experimental autoimmune encephalomyelitis.
authors.affiliation: Institute of Parasitology and Biomedicine, Consejo Superior de Investigaciones Cientificas, 18100 Granada, Spain.
authors.forename: Alejo
authors.initials: A
authors.lastname: Chorny
authors.forename: Elena
authors.initials: E
authors.lastname: Gonzalez-Rey
authors.forename: Amelia
authors.initials: A
authors.lastname: Fernandez-Martin
authors.forename: David
authors.initials: D
authors.lastname: Pozo
authors.forename: Doina
authors.initials: D
authors.lastname: Ganea
authors.forename: Mario
authors.initials: M
authors.lastname: Delgado
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000628:therapy; D015551:Autoimmunity / Q000276:immunology; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000628:therapy; D007108:Immune Tolerance; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology; D014660:Vasoactive Intestinal Peptide / Q000276:immunology / Q000494:pharmacology*
chemical_list: D014660:Vasoactive Intestinal Peptide