Synaptonemal complex formation: where does it start?
The synaptonemal complex is a prominent, evolutionarily conserved feature of meiotic prophase. The assembly of this structure is closely linked to meiotic recombination. A recent study in budding yeast reveals an unexpected role in centromere pairing for a protein component of the synaptonemal complex, Zip1. These findings have implications for synaptonemal complex formation.
Henderson
Kiersten A
KA
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. s-keeney@ski.mskcc.org
Keeney
Scott
S
D002503:Centromere / Q000378:metabolism; D009687:Nuclear Proteins; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D013573:Synaptonemal Complex / Q000378:metabolism*
D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; C090118:Zip1 protein, S cerevisiae