Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats.
Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.
Stief
Frank
F
Neurowissenschaftliches Forschungszentrum der Charité, Schumannstr. 20/21, 10117 Berlin, Germany.
Piechotta
Antje
A
Gabriel
Sigrun
S
Schmitz
Dietmar
D
Draguhn
Andreas
A
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D018755:GABA Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D018721:Muscarinic Agonists / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009557:Nipecotic Acids / Q000494:pharmacology; D018408:Patch-Clamp Techniques / Q000379:methods; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*; D000078308:Tiagabine; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D018755:GABA Agonists; D018721:Muscarinic Agonists; D009557:Nipecotic Acids; D010862:Pilocarpine; D005680:gamma-Aminobutyric Acid; D000078308:Tiagabine