New 24-membered macrolides SPA-6952A and B produced by Streptomyces sp.
Two new 24-membered macrolides, SPA-6952A and B, were isolated from the fermentation broth of Streptomyces sp. SPA-6952. The structures of the new macrolides were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells.
Hosotani
Nobuo
N
Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co., Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan. hosotani@sumitomopharm.co.jp
Kumagai
Kazuo
K
Nakagawa
Hiroyuki
H
Shimatani
Takuro
T
Saji
Ikutaro
I
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D018922:HL-60 Cells; D006801:Humans; D018942:Macrolides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D008968:Molecular Conformation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C504250:SPA 6952A; C504251:SPA 6952B