Determinants of serum lipoprotein(a) concentration in normolipidaemic individuals without clinical atherosclerosis.
BACKGROUND
Lipoprotein(a) (Lp(a)) is an independent risk factor for coronary artery diseases. The main objective of this work was to evaluate the determinants of plasma Lp(a) concentrations in normolipidaemic individuals.


METHODS
Immunonephelometric quantification of Lp(a) was made in 177 volunteers. A multivariate analysis was employed to verify the influence of clinical and biochemical parameters on plasma Lp(a) concentration.


RESULTS
The serum Lp(a) concentration in this population ranged from 0.7 to 40 nmol/L. The Lp(a) predictors were: sex (female), HDL2 triglyceride (negative) and LDL-cholesterol (positive).


CONCLUSIONS
The modulation of plasma Lp(a) concentration in this study points to pro-atherogenic lipoprotein associations.
Dalpino
F
F
Departamento de Patologia Clínica da Faculdade de Ciências Médicas, Universidade Estadual de Campinas, São Paulo, Brasil.
Sodré
F L
FL
Castilho
L N
LN
de Faria
E C
EC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results
D008055:Lipids; D017270:Lipoprotein(a)