title: The susceptibility of certain bacterial strains to imidazotriazine derivatives.
abstract: The synthesized imidazo[2,1-c]triazines were tested for their antimicrobial activity. Microbiological screening tests conducted in relation to 54 strains of Gram-positive and 52 strains of Gram-negative bacteria, 6 strains of yeast-like fungi and 3 strains of moulds showed significant activity of compound 19 against 52 Gram-negative bacterial strains. This compound was active against 16 strains of Escherichia coli, 12 strains of Pseudomonas, 10 strains of Proteus spp., 8 strains of Klebsiella pneumoniae and 6 strains of Enterobacter aerogenes in the examined concentrations (100 microg ml(-1) and 200 microg ml(-1)).
authors.affiliation: Department of Synthesis and Technology of Drugs, Skubiszewski Medical University of Lublin.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Sztanke
authors.forename: Anna
authors.initials: A
authors.lastname: Sidor-Wójtowicz
authors.forename: Janina
authors.initials: J
authors.lastname: Truchlińska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Pasternak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sztanke
mesh_terms: D005658:Fungi / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D014227:Triazines / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects
chemical_list: D007093:Imidazoles; D014227:Triazines