Histological picture of intestinal mucosa of rats after simultaneous administration of atorvastatin and ethyl alcohol.
The rats received atorvastatin in the therapeutical dose and 10x higher, 20% solution of ethanol and ethanol with atorvastatin for 6 weeks. The microscopic investigations (H + E staining, Masson's method, PAS method by McManus) showed no changes in histological picture of intestinal mucosa after giving atorvastatin. The rats receiving alcohol and alcohol with atorvastatin showed similar changes, but different than the first groups. Under the epithelium of intestinal villi there were observed light, vesicle-like spaces, separation of epithelium from connective tissue stroma, also lack of the epithelium of the top of villi and hyperaemia of stroma of villi. The observed changes were stronger in rats receiving simultaneously alcohol and atorvastatin in the dose 10x higher than therapeutical. Hyperaemia of connective tissue of stroma of villi was still visible after month period of administration.
Kifer-Wysocka
Ewa
E
Department and Institute of Histology and Embryology with the Laboratory for Experimental Cytology, Skubiszewski Medical University of Lublin.
Romanowska-Sarlej
Jadwiga
J
Matysiak
Włodzimierz
W
Lis-Sochocka
Marta
M
Jedrych
Barbara
B
Czerny
Krystyna
K
D000818:Animals; D000069059:Atorvastatin; D000431:Ethanol / Q000633:toxicity*; D006538:Heptanoic Acids / Q000633:toxicity*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D011758:Pyrroles / Q000633:toxicity*; D051381:Rats
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000431:Ethanol; D000069059:Atorvastatin