Double-blind, placebo-controlled study of the efficacy of nandrolone laurate in the treatment of dobermanns with subclinical hepatitis.
Twenty-one three-year-old dobermanns with subclinical hepatitis were treated with nandrolone laurate or a placebo in a double-blind trial. The dogs were scored clinically before and after four months of treatment and they were evaluated by clinical biochemistry and liver biopsies. After the treatment no significant differences were observed between the two groups in any of the clinical biochemistry values; eight of the 21 dogs had no histological evidence of hepatitis and five other dogs had improved, but there was no significant difference between the responses of the two groups.
Mandigers
P J J
PJ
Department of Clinical Sciences of Companion Animals, PO Box 80154, University of Utrecht, 3508 TD Utrecht, The Netherlands.
Horspool
L J L
LJ
van den Ingh
T S G A M
TS
Teske
E
E
Bode
P
P
Rothuizen
J
J
D000728:Androgens / Q000627:therapeutic use*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D006520:Hepatitis, Animal / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D008297:Male; D009277:Nandrolone / Q000627:therapeutic use*; D010919:Placebos; D016896:Treatment Outcome
D000728:Androgens; D010919:Placebos; D009277:Nandrolone