Preparation and biocompatibility of novel UV-curable chitosan derivatives.
UV-curable chitosans (UVCC-7-10) were synthesized using less-toxic agents. The UVCC-7 was completely cured by UV spot irradiation for 4 s. The UVCC-7 was implanted into murine subcutaneous tissues, and the response to the implantation was observed by histological examination at 7 days after implantation. In the histological findings, the implant was surrounded by thin fibrous granulating tissue with no inflammatory cellular infiltration. Fibroblasts infiltrate between the cured implant. The novel synthesized UVCC-7 showed good biocompatibility.
Renbutsu
Eiko
E
Department of Clinical Veterinary Medicine, Tottori University, 4-101 Koyma-Minami, Tottori 680-8553, Japan.
Hirose
Masaru
M
Omura
Yoshihiko
Y
Nakatsubo
Fumiaki
F
Okamura
Yasuhiko
Y
Okamoto
Yoshiharu
Y
Saimoto
Hiroyuki
H
Shigemasa
Yoshihiro
Y
Minami
Saburo
S
D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002240:Carbohydrate Sequence; D048271:Chitosan / Q000737:chemistry*; D003487:Cyanoacrylates / Q000737:chemistry / Q000494:pharmacology; D004817:Epidermis / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D020007:Implants, Experimental; D007249:Inflammation; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000378:metabolism; D011897:Random Allocation; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D017550:Spectroscopy, Fourier Transform Infrared; D013997:Time Factors; D014466:Ultraviolet Rays
D000447:Aldehydes; D001672:Biocompatible Materials; D003487:Cyanoacrylates; D048271:Chitosan