Polycyclic aromatic hydrocarbon-DNA adduct formation in prostate carcinogenesis.
The evidence for polycyclic aromatic hydrocarbons (PAH) playing a role in prostate carcinogenesis comes mainly from associations between reported PAH exposures and prostate cancer in epidemiologic studies. Associations between prostate cancer and DNA repair genotypes and phenotypes have also been reported, lending further credence to a PAH-induced carcinogenesis pathway in prostate cancer. Recent work that demonstrates the human prostate has metabolic enzyme activity necessary for PAH activation and will form DNA adducts upon exposure to PAH further supports PAH carcinogenesis. We have demonstrated the presence of PAH-DNA adducts in prostate cancer cases, but further validation of this biomarker as a carcinogenic agent in human prostate is needed.
Rybicki
Benjamin A
BA
Department of Biostatistics and Research Epidemiology, Henry Ford Health System, 1 Ford Place 3E, Detroit, MI 48202, USA. brybick1@hfhs.org
Nock
Nora L
NL
Savera
Adnan T
AT
Tang
Deliang
D
Rundle
Andrew
A
D018736:DNA Adducts / Q000096:biosynthesis*; D004249:DNA Damage; D004260:DNA Repair; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D011083:Polycyclic Compounds / Q000378:metabolism / Q000633:toxicity*; D011471:Prostatic Neoplasms / Q000378:metabolism*
D018736:DNA Adducts; D011083:Polycyclic Compounds