title: Pilot clinical trial of 18F-fluorodeoxyglucose positron-emission mammography in the surgical management of breast cancer.
abstract: BACKGROUND
  High-resolution positron-emission mammography (PEM) is a new device, which allows the imaging of breast tissue. A prospective study was performed to assess the accuracy of PEM in newly diagnosed breast cancer patients.
  
  
  METHODS
  In a prospective multicenter study, 44 women with confirmed breast cancers were imaged with a high-resolution PEM scanner (Naviscan PET Systems, Rockville, MD) with 18F-fluorodeoxyglucose. The images were blindly evaluated and were compared with final pathology.
  
  
  RESULTS
  The majority of the index lesions were seen on PEM (89%, 39/44). PEM detected 4 of 5 incidental breast cancers, 3 of which were not seen by any other imaging modalities. Of 19 patients undergoing breast-conserving surgery, PEM correctly predicted 6 of 8 (75%) patients with positive margins and 100% (11/11) with negative margins.
  
  
  CONCLUSIONS
  The current PEM device shows promise in detecting breast malignancies and may assist in the planning of adequate partial mastectomy procedures to better ensure negative margins.
authors.affiliation: The Breast Center, Anne Arundel Health Systems, 2002 Medical Parkway, Suite 120, Annapolis, MD 21401, USA. ltafra@aahs.org
authors.forename: Lorraine
authors.initials: L
authors.lastname: Tafra
authors.forename: Zandra
authors.initials: Z
authors.lastname: Cheng
authors.forename: Joseph
authors.initials: J
authors.lastname: Uddo
authors.forename: Mary B
authors.initials: MB
authors.lastname: Lobrano
authors.forename: William
authors.initials: W
authors.lastname: Stein
authors.forename: Wendie A
authors.initials: WA
authors.lastname: Berg
authors.forename: Edward
authors.initials: E
authors.lastname: Levine
authors.forename: Irving N
authors.initials: IN
authors.lastname: Weinberg
authors.forename: Deepa
authors.initials: D
authors.lastname: Narayanan
authors.forename: Eric
authors.initials: E
authors.lastname: Ross
authors.forename: David
authors.initials: D
authors.lastname: Beylin
authors.forename: Stephen
authors.initials: S
authors.lastname: Yarnall
authors.forename: Rochelle
authors.initials: R
authors.lastname: Keen
authors.forename: Kristen
authors.initials: K
authors.lastname: Sawyer
authors.forename: Jack
authors.initials: J
authors.lastname: Van Geffen
authors.forename: Rita L
authors.initials: RL
authors.lastname: Freimanis
authors.forename: Edward
authors.initials: E
authors.lastname: Staab
authors.forename: Lee P
authors.initials: LP
authors.lastname: Adler
authors.forename: Judy
authors.initials: J
authors.lastname: Lovelace
authors.forename: Perry
authors.initials: P
authors.lastname: Shen
authors.forename: John
authors.initials: J
authors.lastname: Stewart
authors.forename: Sergei
authors.initials: S
authors.lastname: Dolinsky
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D016037:Single-Blind Method
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18