title: The influence of experimental administration of ethanol and cephalexin on stomach mucous barrier of rat.
abstract: The Wistar rat males weighing approximately 200 g were administered 20% ethanol ad libitum during 10 days, cephalexin in the dose of 42 mg/24 h, and simultaneously ethanol and cephalexin in the above-mentioned doses. After 10 days the animals were decapitated and stomach specimens were taken from the major curvature region for examinations. They were fixed in 10% formalin, dehydrated and immersed in paraffin. For the purpose of estimation changes in activity of gastric gland mucous cells Mc Manus's PAS reaction was performed on 7 micro-thick sections. It was found that ethanol causes functional decrease in the activity of mucous cells. However, cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. A simultaneous administration of ethanol and cephalexin causes atrophic changes in gastric glands, and thereby strong reduction of mucous cells activity.
authors.affiliation: Department of Histology and Embryology, Lab of Experimental Cytology, Skubiszewski Medical University of Lublin.
authors.forename: Alicja
authors.initials: A
authors.lastname: Zarebska
authors.forename: Daria
authors.initials: D
authors.lastname: Hernik
authors.forename: Janusz
authors.initials: J
authors.lastname: Matusiewicz
authors.forename: Krystyna
authors.initials: K
authors.lastname: Czerny
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002506:Cephalexin / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000431:Ethanol; D002506:Cephalexin