Evidence of QTLs on chromosomes 13q and 14q for triglycerides before and after 20 weeks of exercise training: the HERITAGE Family Study.
Fasting triglyceride (TG) levels in total plasma and in lipoprotein subfractions were assessed both at baseline and after a 20-week exercise training intervention in 99 White and 101 Black families. A genome-wide multipoint variance component linkage analysis was performed separately by race, using 509 markers. The strongest evidence of linkage was for the TG subfractions of low-density lipoprotein (LDL-TG) and high-density lipoprotein (HDL-TG) rather than for overall levels of TG. For baseline levels, the maximum LOD score was 3.8 on 13q12-q14 with HDL-TG in Whites. Additional linkage evidence was found on 14q31 (LOD=3.2) and 10p14 (LOD=2.9) for baseline LDL-TG in Whites. Suggestive linkage signal at baseline in Whites was detected for HDL-TG (LOD=2.6) on 12q24 and for LDL-TG on 19p13. For training response in Whites, suggestive signal (LOD=2.2) was observed on 13q12-q14 with LDL-TG and for HDL-TG on 10q23. For Blacks, weak signals (LODs<2.0) were found either for baseline and responses to training, perhaps due to small sample sizes that reduced the power of the linkage analysis. These results represent the first report of linkage for the lipoprotein subfractions and for the lipid and lipoprotein responses to exercise training. It is interesting that the strongest signals were found for the LDL-TG and HDL-TG subfractions, given their particular relationships with the atherogenic lipid profile including dense LDL and HDL particles.
Feitosa
Mary F
MF
Division of Biostatistics, Campus Box 8067 Washington University School of Medicine, 660 S. Euclid, Saint Louis, MO 63110-1093, USA. maryf@wubios.wustl.edu
Rice
Treva
T
Rankinen
Tuomo
T
Province
Michael A
MA
Chagnon
Yvon C
YC
Gagnon
Jacques
J
Leon
Arthur S
AS
Skinner
James S
JS
Wilmore
Jack H
JH
Després
Jean-Pierre
JP
Bouchard
Claude
C
Rao
D C
DC
Borecki
Ingrid B
IB
D000293:Adolescent; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000208:ethnology / Q000235:genetics; D044383:Black People / Q000235:genetics; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D050171:Dyslipidemias / Q000208:ethnology* / Q000235:genetics*; D015444:Exercise; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D006801:Humans; D008297:Male; D008875:Middle Aged; D040641:Quantitative Trait Loci; D014280:Triglycerides / Q000097:blood*; D044465:White People / Q000235:genetics
D014280:Triglycerides