Septations in chronic spinal cord injury cavities contain axons.
Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated. Here, we show for the first time in a rodent model of chronic SCI that the septations spanning cavities contain axons.
Radojicic
Milan
M
Reeve-Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, College of Medicine, University of California Irvine, Irvine, CA 92697-4292, USA.
Reier
Paul J
PJ
Steward
Oswald
O
Keirstead
Hans S
HS
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D046529:Microscopy, Electron, Transmission / Q000379:methods; D051381:Rats; D013116:Spinal Cord / Q000473:pathology / Q000648:ultrastructure; D013119:Spinal Cord Injuries / Q000150:complications* / Q000473:pathology*; D013194:Staining and Labeling / Q000379:methods; D014855:Wallerian Degeneration / Q000209:etiology* / Q000473:pathology