title: Neopetrosiamides, peptides from the marine sponge Neopetrosia sp. that inhibit amoeboid invasion by human tumor cells.
abstract: [structure: see text] Neopetrosiamdes A (1) and B (2), two diastereomeric tricyclic peptides that inhibit amoeboid invasion of human tumor cells, have been isolated from the marine sponge Neopetrosia sp. collected in Papua New Guinea. The structures of the neopetrosiamides were elucidated by analysis of MS and NMR data and confirmed by chemical degradation.
authors.affiliation: Department of Chemistry, Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Pamela
authors.initials: P
authors.lastname: Austin
authors.forename: Ana R
authors.initials: AR
authors.lastname: Diaz-Marrero
authors.forename: Rob Van
authors.initials: RV
authors.lastname: Soest
authors.forename: Teatulohi
authors.initials: T
authors.lastname: Matainaho
authors.forename: Calvin D
authors.initials: CD
authors.lastname: Roskelley
authors.forename: Michel
authors.initials: M
authors.lastname: Roberge
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D012451:Safrole / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010455:Peptides; D010456:Peptides, Cyclic; C512184:neopetrosiamide A; C512185:neopetrosiamide B; D008715:Methionine; D012451:Safrole; C005746:sulfoxide; C013111:methionine sulfoxide