[Study of the clinicopathology on verruciform xanthoma of the oral cavity].
OBJECTIVE
Three cases of oral cavity mucosal verruciform xanthoma were studied to investigate the pathogenesis of verruciform xanthoma.


METHODS
Immunohistochemical staining with S-P and in situ hybridization using the probe to detect HPV mRNA and MMP-2, MMP-9 RNA.


RESULTS
The foam cells were strongly positive for CD68 (KP1) and Vimentin. The cytokeratin, PCNA and S-100 showed negative in foam cells. ISH testing failed to detect HPV (types 6, 11, 16, 18) in any of the three cases of verruciform xanthoma. MMP-2, MMP-9 showed positive staining in epithelial cells and foam cells.


CONCLUSIONS
Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells like that, are most likely derived from monocyte-macrophage lineage.
Hu
Ji-an
JA
Department of Oral Pathology, School of Stomatology, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. hja@zju.edu.cn
Li
Yi-ning
YN
Li
Song-ying
SY
Ying
Hong
H
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D005487:Foam Cells / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology*; D027383:Papillomaviridae / Q000302:isolation & purification; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D014973:Xanthomatosis / Q000378:metabolism / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007633:Keratins; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D018809:Proliferating Cell Nuclear Antigen; D009418:S100 Proteins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C522361:MMP2 protein, human; C579270:MMP9 protein, human