A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering.
Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.
Round
A R
AR
Daresbury Laboratories, Warrington, WA4 4AD, UK. A.R.Round@DL.ac.uk
Wilkinson
S J
SJ
Hall
C J
CJ
Rogers
K D
KD
Glatter
O
O
Wess
T
T
Ellis
I O
IO
D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011859:Radiography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014961:X-Ray Diffraction / Q000379:methods*