title: Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin.
abstract: Lactic acidosis is a known adverse risk of metformin treatment. We report two cases in whom fulminant lactic acidosis developed during treatment. There were no contraindications to metformin treatment and both were admitted with abdominal discomfort for some days, causing dehydration. Both patients had renal failure on admission, developed multiple organ failure and both suffered a massive stroke. One patient died and the other survived but is severely disabled. We suggest, in both cases, that acute renal failure developed as a result of dehydration, causing metformin accumulation and lactic acidosis. We recommend that all patients on metformin should consider discontinuation of metformin treatment in the event of a severe medical condition causing dehydration.
authors.affiliation: Department of Endocrinology C, Aarhus Amtssygehus, Aarhus Universitetshospitalet, Aarhus, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Brassøe
authors.forename: T
authors.initials: T
authors.lastname: Elkmann
authors.forename: M
authors.initials: M
authors.lastname: Hempel
authors.forename: C H
authors.initials: CH
authors.lastname: Gravholt
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000150:complications*; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin