The determinants of bone mineral density in Chinese men--results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men.
Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65-92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.
Lau
E M C
EM
Hong Kong Orthopaedic and Osteoporosis Center for Treatment and Research, Unit 1301, Hing Wai Building, 36 Queen's Road Central, Hong Kong, China. edithmclau@netvigator.com
Leung
P C
PC
Kwok
T
T
Woo
J
J
Lynn
H
H
Orwoll
E
E
Cummings
S
S
Cauley
J
J
D015502:Absorptiometry, Photon / Q000379:methods; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D017677:Age Distribution; D000368:Aged; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D015331:Cohort Studies; D006615:Hip / Q000503:physiopathology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008019:Life Style; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D005082:Physical Exertion / Q000502:physiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013131:Spine / Q000503:physiopathology
D000305:Adrenal Cortex Hormones