title: [Investigation of cerebral autoregulation in Parkinson's disease--a transcranial Doppler study].
abstract: OBJECTIVE
  The frequent orthostatic intolerance in Parkinson's disease could be the consequence of cardiovascular autonomic failure and/or a damaged cerebral autoregulation (AR). To clarify this question the regulation of cerebral circulation was investigated by polygraphic method.
  
  
  METHODS
  On a tilt table simultaneous and continuous registrations were made of MCA velocity (V(MCA)) by transcranial Doppler, arterial blood pressure by non-invasive method, and end-tidal CO2, in supine and in tilted positions of 10 degrees, 30 degrees, 70 degrees grades. The cerebral autoregulation was characterized by the slope of the curve of the arterial blood pressure at the level of the Willis-circle (BP(W) as MCA perfusion pressure) plotted against the MCA velocity, achieved by linear regression (y = ax + b function, a=AR, or index of autoregulation).
  
  
  METHODS
  The data of 17 parkinsonian patients (PP) and eight age-matched controls (C) were analyzed.
  
  
  RESULTS
  The decrease of blood pressure in parkinsonian patients was significantly lower than in the controls when supine position was restored from 70 degrees (deltaABP 70 degrees - 0 degree pp = -3.1 +/- 7.5 Hgmm; deltaABP 70 degrees - 0(C) degrees = -11.1 +/- 7.3 Hgmm; p < 0.05), which suggests a damage to the sympathetic cardiovascular system. A disturbance of the cerebral autoregulation in patients was suggested by a 'progressively decreasing MCA average velocity (V(MCA)) during graded tilt, which was significant at 70 degrees (deltaV(ACM) = 9.8 +/- 8.82% cms(-1); p(C-PP) P 0.5), and by a higher slope of pressure-velocity curve (AR(C) = 0.143 +/- .125% cms(-1)/Hgmm; AR(PP) = 0.38 +/- 0.25% cms(-1)/Hgmm; p(C-PP) < 0.05).
  
  
  CONCLUSIONS
  The results show that the cerebral blood flow of patients is more dependent on perfusion pressure compared to healthy controls. The disturbance of the sympathetic cardiovascular system and of cerebral autoregulation could be the consequence of a damage to the postganglionic structures in Parkinson's disease. These results could explain the frequent orthostatic intolerance of patients even with normal blood pressure.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, Neurológiai Klinika, Budapest. debre@neur.sote.hu
authors.forename: Róbert
authors.initials: R
authors.lastname: Debreczeni
authors.forename: Ilona
authors.initials: I
authors.lastname: Amrein
authors.forename: Márk
authors.initials: M
authors.lastname: Kollai
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Lénárd
authors.forename: László
authors.initials: L
authors.lastname: Pálvölgyi
authors.forename: Annamária
authors.initials: A
authors.lastname: Takáts
authors.forename: Gertrúd
authors.initials: G
authors.lastname: Tamás
authors.forename: Imre
authors.initials: I
authors.lastname: Szirmai
mesh_terms: D000368:Aged; D001794:Blood Pressure; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D002941:Circle of Willis; D005260:Female; D006706:Homeostasis; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial