title: Molecular modeling, synthesis, and preliminary biological evaluation of glutathione-S-transferase inhibitors as potential therapeutic agents.
abstract: Changes in the GSH/GST system have been found to correlate with resistance to anticancer alkylating agents, presumably through accelerated detoxification of these drugs since some GSTs have been shown to catalyze the conjugation of GSH to specific antineoplastic agents. GSH-alkyl derivatives were designed by molecular modeling, synthesized, and tested as inhibitors of human GST-Pi.
authors.affiliation: Dipartimento di Scienze Farmaco-Biologiche, Università della Magna Graecia, Complesso Ninì Barbieri, 88021 Roccelletta di Borgia (Cz), Italy. procopio@unicz.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Procopio
authors.forename: Stefano
authors.initials: S
authors.lastname: Alcaro
authors.forename: Sante
authors.initials: S
authors.lastname: Cundari
authors.forename: Antonio
authors.initials: A
authors.lastname: De Nino
authors.forename: Francesco
authors.initials: F
authors.lastname: Ortuso
authors.forename: Paolo
authors.initials: P
authors.lastname: Sacchetta
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pennelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sindona
mesh_terms: D020134:Catalytic Domain; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D005978:Glutathione / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship
chemical_list: D005982:Glutathione Transferase; D005978:Glutathione; D005027:Ethylene Oxide