The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. I. Taxonomy, fermentation, isolation and physico-chemical properties.
FR225654, a novel gluconeogenesis inhibitor, was isolated from the culture broth of Phoma sp. No. 00144 and purified by adsorptive resin and reverse-phase column chromatography. This compound is a potent inhibitor of gluconeogenesis and is a promising candidate of anti-diabetic agent.
Ohtsu
Yoshihiro
Y
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd. yoshihiro.ohtsu@jp.astellas.com
Sasamura
Hiromi
H
Tanaka
Miho
M
Tsurumi
Yasuhisa
Y
Yoshimura
Seiji
S
Takase
Shigehiro
S
Shibata
Toshihiro
T
Hino
Motohiro
M
Nakajima
Hidenori
H
D000818:Animals; D002478:Cells, Cultured; D005285:Fermentation; D005658:Fungi; D005943:Gluconeogenesis / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
C504133:FR225654; D007004:Hypoglycemic Agents; D009281:Naphthalenes