title: Autonomic function after botulinum toxin type A or B: a double-blind, randomized trial.
abstract: To compare autonomic effects of botulinum toxin (BTX), we randomized patients with cervical dystonia to receive either BTX-A or BTX-B in a double-blind manner. Efficacy and physiologic questionnaire measures of autonomic function were assessed at baseline and 2 weeks after injection. Patients treated with BTX-B had less saliva production (p < 0.01) and greater severity of constipation (p = 0.037) than those treated with BTX-A, but did not differ in other tests of autonomic functions.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, TX, USA. rtintner@tmh.tmc.edu
authors.forename: R
authors.initials: R
authors.lastname: Tintner
authors.forename: R
authors.initials: R
authors.lastname: Gross
authors.forename: U F
authors.initials: UF
authors.lastname: Winzer
authors.forename: K A
authors.initials: KA
authors.lastname: Smalky
authors.forename: J
authors.initials: J
authors.lastname: Jankovic
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000009:adverse effects*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002799:Cholinergic Fibers / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D017615:Enteric Nervous System / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects; D017729:Presynaptic Terminals / Q000187:drug effects / Q000502:physiology; D012025:Reflex, Pupillary / Q000187:drug effects / Q000502:physiology; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D014103:Torticollis / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A