Molecular evidence of recurrent histoplasmosis with 9-year latency in a patient with Addison's disease.
We present a case of fatal histoplasmosis in a patient with Addison's disease and long-term use of corticosteroid. The patient acquired Histoplasma capsulatum in China and initially presented with a laryngeal mass. He developed fulminant pneumonia and respiratory failure 9 years later. Nucleotide sequences of internal transcribed spacer regions of rRNA genes of the H. capsulatum isolate recovered from biopsied lung tissue and of the extracted fungal DNA from the laryngeal lesion were identical, indicating the recurrent nature of infection.
Tseng
Tai-Chung
TC
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei.
Liaw
Shwu-Jen
SJ
Hsiao
Cheng-Hsiang
CH
Wang
Cheng-Yi
CY
Lee
Li-Na
LN
Huang
Tien-Shang
TS
Hsueh
Po-Ren
PR
D000224:Addison Disease / Q000150:complications*; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D021903:DNA, Ribosomal Spacer / Q000032:analysis; D006658:Histoplasma / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D012340:RNA, Ribosomal, 5.8S / Q000235:genetics; D012008:Recurrence; D017422:Sequence Analysis, DNA; D013997:Time Factors
D021903:DNA, Ribosomal Spacer; D012340:RNA, Ribosomal, 5.8S