Induction of SAP7 correlates with virulence in an intravenous infection model of candidiasis but not in a vaginal infection model in mice.
SAP7 of Candida albicans is induced after vaginal infection of mice. Conversely, virulence during vaginal infection was not affected in a Deltasap7/Deltasap7 mutant strain. Only a partial virulence phenotype was detectable after intravenous injection. In conclusion, SAP7 expression does not correlate with C. albicans virulence in mice.
Taylor
Brad N
BN
Institute of Clinical Microbiology, Immunology, and Hygiene, Friedrich-Alexander University Erlangen-Nürnberg, Germany.
Hannemann
Holger
H
Sehnal
Miriam
M
Biesemeier
Antje
A
Schweizer
Anja
A
Röllinghoff
Martin
M
Schröppel
Klaus
K
D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics / Q000378:metabolism*; D002175:Candida / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity*; D002177:Candidiasis / Q000382:microbiology*; D004195:Disease Models, Animal; D005260:Female; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D051379:Mice; D009154:Mutation; D014621:Vagina / Q000382:microbiology; D014623:Vaginal Diseases / Q000382:microbiology*; D014774:Virulence
D005656:Fungal Proteins; D016282:Aspartic Acid Endopeptidases