[Status of immune response and possibilities of its correction during the severe surgical infections of the maxillo-facial region].
The study of the immune status of the 30 patients with suppurative-septic diseases of the maxillo-facial region reveal the marked changes such as the deviation of the functions of antigen-presenting cells (macrophages, monocytes). The antigen specific immune-response system is disturbed as well (CD4+, CD8+); the production of the protective immune globulins (B cells) is abnormal. The serious suppression of interferon system occurs (suppression of the activities of INFalpha and INFgamma). The cytokine therapy using the Ronkoleukine, in association with systemic antibacterial therapy (patients with the severe forms of surgical infection of maxillo-facial region) during the 10-12 days markedly improve deviation of the immune status. It diminishes the degree of the endogen toxemia and reduces the time of recovery.
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D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002481:Cellulitis / Q000276:immunology* / Q000601:surgery*; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D013515:Surgery, Oral / Q000379:methods*; D013530:Surgical Wound Infection / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000900:Anti-Bacterial Agents; D016207:Cytokines; D016898:Interferon-alpha