[Elimination of haloperidol from erythrocytes surfaces supernatant and blood plasma].
The aim of the study was to investigate the adsorption rate of haloperidol on erythrocytes surfaces. The pharmacokinetic and pharmacodynamic parameters of haloperidol were monitored in the experiment. The neuroleptic was administered to 12 adult dogs and the blood samples were collected for further analysis following 20, 30, 60, 180, 240, 360, 420 and 480 minutes after the injection. The groups of samples (blood plasma and supernatant) were monitored during this period. The differences between haloperidol concentration in the supernatant and blood plasma were compared. Our data have shown that dynamics of the elimination of intact and acidified forms of haloperidol from the supernatant and the blood serum are not the same. Intact and acidified forms are differently regulated by plasma. albumines and globulines. The process of redistribution of haloperidol between the both substrates takes place, while the supernatant has a donor function for the free form of haloperidol and represents the acceptor of the haloperidol's metabolites. This provides the possibility to develop multidiscipline approach to the optimization to the prescription of haloperidol.
Shanidze
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D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism*; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism*; D006220:Haloperidol / Q000097:blood / Q000493:pharmacokinetics*; D010949:Plasma / Q000378:metabolism
D000954:Antigens, Surface; D006220:Haloperidol