title: Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversy.
abstract: OBJECTIVE
  To determine the influence of diabetes mellitus on coronary collateral flow by accurate means of collateral flow measurement in a large population with variable degrees of coronary artery disease.
  
  
  METHODS
  200 patients (mean (SD) age 64 (9) years; 100 diabetic and 100 non-diabetic) were enrolled in the study. Coronary collateral flow was assessed in 174 stenotic and in 26 angiographically normal vessels with a pressure guidewire (n = 131), Doppler guidewire (n = 36), or both (n = 33) to calculate pressure or flow velocity derived collateral flow index (CFI). Diabetic patients were perfectly matched with a non-diabetic control group for clinical, haemodynamic, and angiographic parameters.
  
  
  RESULTS
  CFI did not differ between the diabetic and the non-diabetic patients (0.21 (0.12) v 0.19 (0.13), not significant). Likewise, CFI did not differ when only angiographically normal vessels (0.20 (0.09) v 0.15 (0.08), not significant) or chronic total coronary occlusions (0.30 (0.14) v 0.30 (0.17), not significant) were compared. Fewer patients in the diabetic group tended to have angina pectoris during the one minute vessel occlusion (60 diabetic v 69 non-diabetic patients, p = 0.15).
  
  
  CONCLUSIONS
  Quantitatively measured coronary CFI did not differ between diabetic and non-diabetic patients with stable coronary artery disease.
authors.affiliation: Department of Cardiology, University Hospital Bern, Bern, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Zbinden
authors.forename: S
authors.initials: S
authors.lastname: Zbinden
authors.forename: M
authors.initials: M
authors.lastname: Billinger
authors.forename: S
authors.initials: S
authors.lastname: Windecker
authors.forename: B
authors.initials: B
authors.lastname: Meier
authors.forename: C
authors.initials: C
authors.lastname: Seiler
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D003097:Collateral Circulation / Q000502:physiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018919:Neovascularization, Physiologic / Q000502:physiology