title: Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin.
abstract: Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
authors.affiliation: Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Zanetti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bua
authors.forename: Giovanni
authors.initials: G
authors.lastname: Delogu
authors.forename: Cinzia
authors.initials: C
authors.lastname: Pusceddu
authors.forename: Maristella
authors.initials: M
authors.lastname: Mura
authors.forename: Franca
authors.initials: F
authors.lastname: Saba
authors.forename: Piero
authors.initials: P
authors.lastname: Pirina
authors.forename: Carlo
authors.initials: C
authors.lastname: Garzelli
authors.forename: Cono
authors.initials: C
authors.lastname: Vertuccio
authors.forename: Leonardo A
authors.initials: LA
authors.lastname: Sechi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fadda
mesh_terms: D000907:Antibodies, Bacterial / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology*; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006388:Hemagglutinins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D037102:Lectins; D008745:Methylation; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006388:Hemagglutinins; D037102:Lectins; D011994:Recombinant Proteins; C104578:heparin-binding hemagglutinin