title: Is craniofacial dysmorpholgy correlated with structural brain anomalies in schizophrenia?
abstract: This study aimed to examine the relationship between craniofacial dysmorphology and anomalies of brain morphology in schizophrenia. Assessments of craniofacial dysmorphology and magnetic resonance imaging of brain were performed independently of each other and blind to each other in 24 males with schizophrenia and 16 male controls. Ventricular cerebrospinal fluid volume was negatively correlated with total dysmorphology score in males with schizophrenia (i.e., the larger the ventricular cerebrospinal fluid volume, the lower the total dysmorphology score) but not in male controls. These findings suggest that craniofacial dysmorphology and anomalies of brain morphology may be associated with independent processes in the etiology of schizophrenia.
authors.affiliation: The Stanley Research Unit, Department of Adult Psychiatry, Hospitaller Order of St John of God, Cluain Mhuire Centre, Newtownpark Avenue, Blackrock, Co. Dublin, Ireland.
authors.forename: Brendan D
authors.initials: BD
authors.lastname: Kelly
authors.forename: Thomas F
authors.initials: TF
authors.lastname: McNeil
authors.forename: Abbie
authors.initials: A
authors.lastname: Lane
authors.forename: Karin M
authors.initials: KM
authors.lastname: Henriksson
authors.forename: Anthony
authors.initials: A
authors.lastname: Kinsella
authors.forename: Ingrid
authors.initials: I
authors.lastname: Agartz
mesh_terms: D000328:Adult; D000886:Anthropometry; D001921:Brain / Q000002:abnormalities*; D002552:Cerebral Ventricles / Q000033:anatomy & histology; D019465:Craniofacial Abnormalities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000453:epidemiology*; D012720:Severity of Illness Index