title: Effects of L.F04, the active fraction of Lycopus lucidus, on erythrocytes rheological property.
abstract: OBJECTIVE
  To study the effects of L.F04, the active fraction of Lycopus lucidus, on erythrocytes rheological property so as to investigate its mechanism in promoting blood circulation and removing blood stasis.
  
  
  METHODS
  The effects of L.F04 (used for treatment for 10 days in different dosages) on deformability, aggregation and membrane liquidity of erythrocytes (MLE) as well as whole blood apparent viscosity (eta(b)) were examined on the basis of rat model of blood-stasis syndrome induced by venous injection of high molecular weight dextran.
  
  
  RESULTS
  As compared with the normal control group, the model group's RBC deformability and MLE were lower, and the aggregation of erythrocytes and eta(b) were higher. Compared with the model group, both L.F04 0.612 g/kg and 0.306 g/kg showed significant effect in improving deformability and inhibiting aggregation of red blood cells (RBC) and reducing blood viscosity. The trend of improving MLE was also shown.
  
  
  CONCLUSIONS
  L.F04 could significantly improve the abnormal rheological property of erythrocytes.
authors.affiliation: Institute of Space Medico-Engineering, Beijing. shihongz2002@yahoo.com.cn
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Shi
authors.forename: Nan-nan
authors.initials: NN
authors.lastname: Gao
authors.forename: Yong-zhi
authors.initials: YZ
authors.lastname: Li
authors.forename: Jing-guang
authors.initials: JG
authors.lastname: Yu
authors.forename: Quan-chun
authors.initials: QC
authors.lastname: Fan
authors.forename: Gui-e
authors.initials: GE
authors.lastname: Bai
authors.forename: Bing-mu
authors.initials: BM
authors.lastname: Xin
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D018056:Hemorheology; D006487:Hemostasis / Q000187:drug effects*; D031333:Lycopus; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013026:Space Flight
chemical_list: D003911:Dextrans; D004365:Drugs, Chinese Herbal