title: Transcriptome analysis of Pseudomonas aeruginosa growth: comparison of gene expression in planktonic cultures and developing and mature biofilms.
abstract: The transcriptomes of logarithmic- and stationary-phase Pseudomonas aeruginosa planktonic cultures and static biofilms of different stages of development were compared. Developing and confluent biofilm transcriptomes were found to be related to those of logarithmic- and stationary-phase planktonic cultures, respectively. In addition, a number of novel genes were up-regulated in developing and confluent biofilms, including genes encoding putative solute transport proteins and transcriptional regulators, respectively.
authors.affiliation: MRC Molecular Pathogenesis Research Unit, Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London, Queen Mary School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, United Kingdom. R.D.Waite@qmul.ac.uk
authors.forename: Richard D
authors.initials: RD
authors.lastname: Waite
authors.forename: Anastasia
authors.initials: A
authors.lastname: Papakonstantinopoulou
authors.forename: Eddie
authors.initials: E
authors.lastname: Littler
authors.forename: Michael A
authors.initials: MA
authors.lastname: Curtis
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D018441:Biofilms / Q000254:growth & development; D015870:Gene Expression; D015964:Gene Expression Regulation, Bacterial; D046228:Microarray Analysis; D010933:Plankton / Q000254:growth & development / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000254:growth & development* / Q000502:physiology
chemical_list: D001426:Bacterial Proteins