[Study on serum levels of E- selectin, integrin beta 1 subunit and intercellular adhesion molecule-1 in gastric cancer patients and their clinical implications].
OBJECTIVE
To evaluate the serum concentrations of E- selectin, integrinbeta(1) subunit and intercellular adhesion molecule-1 in gastric cancer patients and their clinicopathological significance.


METHODS
The serum levels of adhesion molecules E- selectin,intercellular adhesion molecule- 1 (ICAM- 1), and integrinbeta(1) were measured by enzyme-linked immunosorbent assay (ELISA) in 47 health subjects (control group) and in 57 patients with gastric cancer (gastric cancer group) before operation and 7 days after operation. Serum levels of above three factors were compared between the two groups.


RESULTS
The serum concentrations of E- selectin, integrinbeta(1) subunit and ICAM- 1 were higher in gastric cancer group with positive rate of 24.6% ,33.3% ,28.1% respectively. ICAM- 1 and integrinbeta(1) were significant higher in gastric cancer group than that in the control group (P< 0.01),but there was no significant difference in E- selectin between two groups (P=0.64). Serum concentrations of E-selectin, ICAM-1,and integrinbeta(1) were significantly correlated with clinicopathological features as following: clinicopathological stage,invasion depth,lymph node involvement,and presence of distant metastases(P< 0.05,P< 0.01). The serum levels of E- selectin, ICAM- 1, and integrinbeta(1) were decreased significantly after radical resection of gastric cancer,but not in patients with unresectable tumor. Elevated levels of three molecules were significant prognostic factors for patients with gastric cancer,but it could not independently be used to evaluate tumor stage.


CONCLUSIONS
Serum concentrations of E- selectin, ICAM- 1,and integrinbeta(1) may reflect tumor progression and metastasis.
Shao
Qin-shu
QS
Department of General Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China. sqs@163.com
Ye
Zai-yuan
ZY
Ling
Zhi-qiang
ZQ
Zhang
Wei
W
Chen
Xue-rong
XR
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D019012:Integrin beta1 / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D044967:Serum / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D019040:E-Selectin; D019012:Integrin beta1; D018799:Intercellular Adhesion Molecule-1