Different approaches of gene therapy used in prostate cancer.
Prostate cancer is the second leading malignancy next to lung cancer among American males. Estimated number of new cases of prostate cancer by the year 2004 will be 230,110 and number of deaths due to this disease will be 29,900 (American Cancer Society, Surveillance Research, 2004). Major progress have been made in gene therapy due to significant advancement of biology including specialized fields like Molecular Biology, Cell Biology, Immunology and Molecular Virology which includes development of viral and non-viral vectors and delivery system, of which targeted delivery of suicide genes using tissue specific promoter-enhancer, combined therapy, gene replacement therapy are most notable. In this report, we will review about various aspects of gene therapy including most recent discoveries in this field.
Ghosh
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Dept. of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. ghosha@ccf.org
D000818:Animals; D041722:Genes, Transgenic, Suicide / Q000235:genetics; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy; D008297:Male; D011401:Promoter Regions, Genetic / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D014779:Virus Replication