Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice.
The effects of intracerebroventricular (i.c.v.) administration of ultra low doses (ULDs) of histamine, clobenpropit and pyrilamine are studied on morphine state-dependent (STD) memory in mice. Although pre-test administration of different doses of histamine and clobenpropit showed no effect on impairment of memory induced by pre-training morphine, when the above drugs were co-administered with morphine, they inhibited the restoration of memory by morphine. These effects were opposite to microgram doses of the same drugs.
Khalilzadeh
Azita
A
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zarrindast
Mohammad-Reza
MR
Djahanguiri
Bijan
B
D000701:Analgesics, Opioid / Q000008:administration & dosage; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006632:Histamine / Q000008:administration & dosage; D018494:Histamine Agents / Q000008:administration & dosage*; D007093:Imidazoles / Q000008:administration & dosage; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009020:Morphine / Q000008:administration & dosage; D009021:Morphine Dependence / Q000188:drug therapy / Q000503:physiopathology*; D011738:Pyrilamine / Q000008:administration & dosage; D011930:Reaction Time / Q000187:drug effects; D013890:Thiourea / Q000008:administration & dosage / Q000031:analogs & derivatives
D000701:Analgesics, Opioid; D018494:Histamine Agents; D007093:Imidazoles; D009020:Morphine; D006632:Histamine; D013890:Thiourea; D011738:Pyrilamine; C086108:clobenpropit