title: Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.
abstract: Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors). In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. Nimesulide was administered orally, twice a day at the conventional dose of 0.1 g for five days. In the next (or previous) 5 days the same patients were administered with ketoprofen at the dose of 0.05 g three times a day. On the last day of the NSAID administration period, 24-hour blood pressure monitoring was performed. Our results indicate no difference between nimesulide and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
authors.affiliation: Rehabilitation Ward, Department of Internal and Occupational Medicine, Institute of Agricultural Medicine, Lublin.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Saran
authors.forename: Wojciech
authors.initials: W
authors.lastname: Sodolski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sodolska
authors.forename: Wit Cezary
authors.initials: WC
authors.lastname: Danilkiewicz
authors.forename: Janusz
authors.initials: J
authors.lastname: Schabowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007660:Ketoprofen / Q000494:pharmacology*; D008875:Middle Aged; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; D007660:Ketoprofen; C012655:nimesulide