Evaluation of dika nut mucilage (Irvingia gabonensis) as binding agent in metronidazole tablet formulations.
Dika nut mucilage obtained from the nuts of Irvingia gabonensis (O'Rorke) Bail (family Irvingiaceae) has been evaluated as a binding agent in metronidazole tablet formulations in comparison with gelatin BP. The compressional properties of metronidazole formulations were analyzed using density measurements and the Heckel equations as assessment parameters, whereas the mechanical properties of the tablets were assessed using the tensile strength (T), brittle fracture index (BFI), and the friability of the tablets. The drug release properties of the tablets were assessed using disintegration and dissolution times of the tablets. The results obtained indicate that formulations containing dika nut mucilage as binding agent show faster onset of plastic deformation under compression pressure than those containing gelatin. The tensile strength of the tablets increased with increase in concentration of the binding agents, whereas the BFI and friability values decreased. Furthermore, tablets containing dika nut mucilage generally showed lower tensile strength but higher brittleness and friability than those containing gelatin. The results also showed that tablets containing dika nut mucilage generally showed higher disintegration and dissolution times than those containing gelatin BP. The results suggest that dika nut mucilage could be useful in achieving various tablet strength and drug release properties.
Odeku
Oluwatoyin A
OA
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria. pejuodeku@yahoo.com
Patani
Bernard O
BO
D000269:Adhesives; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D008795:Metronidazole / Q000008:administration & dosage*; D013607:Tablets; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
D000269:Adhesives; D013607:Tablets; C051375:dikanut; D008795:Metronidazole; D002482:Cellulose