title: Type 2 diabetes mellitus complicated with smoldering myeloma and non-alcoholic steatohepatitis.
abstract: We report a 59-year-old woman with type 2 diabetes mellitus (DM) complicated with smoldering myeloma and non-alcoholic steatohepatitis. A diagnosis of smoldering myeloma was made on the basis of elevation of IgA, M-protein (type:IgA-lambda) and histological findings of bone marrow without bone lesion. As to liver dysfunction, anti-HBV, anti-HCV and a series of auto-immune antibody were negative. She had no alcohol drinking habit and histological findings showed pericellular fibrosis without fatty degeneration, suggesting liver cirrhosis due to non-alcoholic steatohepatitis (NASH). To date, there are no reports of cases with DM, NASH and myeloma. Particular attention may be necessary for these complications.
authors.affiliation: Division of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Nakahara
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Utsugi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ohyama
authors.forename: Shoichi
authors.initials: S
authors.lastname: Tomono
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Takagi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors