title: Role of the C-type lectins DC-SIGN and L-SIGN in Leishmania interaction with host phagocytes.
abstract: Leishmaniasis is a parasitic disease that courses with cutaneous or visceral clinical manifestations. The amastigote stage of the parasite infects phagocytes and modulates the effector function of the host cells. Our group has described that the interaction between Leishmania and immature monocyte-derived dendritic cells (DCs) takes place through dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), a C-type lectin that specifically recognizes fungal, viral and bacterial pathogens. The DC-SIGN-mediated recognition of Leishmania amastigotes does not induce DC maturation, and the DC-SIGN ligand/s on Leishmania parasites is/are still unknown. We have also found that the DC-SIGN-related molecule L-SIGN, specifically expressed in lymph node and liver sinusoidal endothelial cells, acts as a receptor for L. infantum, the parasite responsible for visceral leishmaniasis, but does not recognize L. pifanoi, which causes the cutaneous form of the disease. Therefore, DC-SIGN and L-SIGN differ in their ability to interact with Leishmania species responsible for either visceral or cutaneous leishmaniasis. A deeper knowledge of the parasite-C-type lectin interaction may be helpful for the design of new DC-based therapeutic vaccines against Leishmania infections.
authors.affiliation: Centro de Investigaciones Biológicas (CSIC), Calle Ramiro de Maeztu 9, 28040 Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Caparrós
authors.forename: Diego
authors.initials: D
authors.lastname: Serrano
authors.forename: Amaya
authors.initials: A
authors.lastname: Puig-Kröger
authors.forename: Lorena
authors.initials: L
authors.lastname: Riol
authors.forename: Fátima
authors.initials: F
authors.lastname: Lasala
authors.forename: Iñigo
authors.initials: I
authors.lastname: Martinez
authors.forename: Fernando
authors.initials: F
authors.lastname: Vidal-Vanaclocha
authors.forename: Rafael
authors.initials: R
authors.lastname: Delgado
authors.forename: José Luis
authors.initials: JL
authors.lastname: Rodríguez-Fernández
authors.forename: Luis
authors.initials: L
authors.lastname: Rivas
authors.forename: Angel L
authors.initials: AL
authors.lastname: Corbí
authors.forename: María
authors.initials: M
authors.lastname: Colmenares
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology* / Q000378:metabolism; D007891:Leishmania / Q000276:immunology* / Q000378:metabolism; D007896:Leishmaniasis / Q000276:immunology* / Q000378:metabolism; D010586:Phagocytes / Q000469:parasitology*; D011956:Receptors, Cell Surface / Q000276:immunology* / Q000378:metabolism; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human