Metagenomics-based drug discovery and marine microbial diversity.
As the global threat of drug-resistant pathogens continues to rise, new strategies and resources are required to accelerate and advance the drug discovery process. We believe that rapid progress in metagenomics has opened up a new era in the study of marine microbial diversity that enables direct access to the genomes of numerous uncultivable microorganisms. This review outlines recent developments and future trends in metagenomics-based drug discovery in marine microbial communities and their associated chemical prosperity.
Li
Xiang
X
South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, China 510301. lixiang@scsio.ac.cn
Qin
Ling
L
D002874:Chromosome Mapping / Q000379:methods*; D015195:Drug Design; D014644:Genetic Variation / Q000235:genetics; D005827:Genetics, Microbial / Q000379:methods / Q000639:trends; D023281:Genomics / Q000379:methods*; D008386:Marine Biology / Q000379:methods* / Q000639:trends*; D004364:Pharmaceutical Preparations; D014871:Water Microbiology
D004364:Pharmaceutical Preparations