Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin.
Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Zanetti
Stefania
S
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Bua
Alessandra
A
Delogu
Giovanni
G
Pusceddu
Cinzia
C
Mura
Maristella
M
Saba
Franca
F
Pirina
Piero
P
Garzelli
Carlo
C
Vertuccio
Cono
C
Sechi
Leonardo A
LA
Fadda
Giovanni
G
D000907:Antibodies, Bacterial / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology*; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006388:Hemagglutinins / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D037102:Lectins; D008745:Methylation; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006388:Hemagglutinins; D037102:Lectins; D011994:Recombinant Proteins; C104578:heparin-binding hemagglutinin