title: Stereoselective syntheses of (+/-)-komaroviquinone and (+/-)-faveline methyl ether through intramolecular Heck reaction.
abstract: [reaction: see text] An efficient, flexible, and stereoselective convergent route for constructing the trans-10-hydroxy-1,1-dimethyloctahydrodibenzo[a,d]cyclohepten-7-ones (5a-c) was achieved via intramolecular Heck reaction. This strategy has been successfully implemented for the syntheses of (+/-)-komaroviquinone (3) through (+/-)-coulterone dimethyl ether (5c) and (+/-)-faveline methyl ether (1a).
authors.affiliation: Medicinal Chemistry Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata-700 032, India.
authors.forename: Sujaya
authors.initials: S
authors.lastname: Sengupta
authors.forename: Michael G B
authors.initials: MG
authors.lastname: Drew
authors.forename: Ranjan
authors.initials: R
authors.lastname: Mukhopadhyay
authors.forename: Basudeb
authors.initials: B
authors.lastname: Achari
authors.forename: Asish Kr
authors.initials: AK
authors.lastname: Banerjee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D004224:Diterpenes / Q000138:chemical synthesis*; D011809:Quinones / Q000138:chemical synthesis*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D011809:Quinones; C508550:komaroviquinone