Pilot clinical trial of 18F-fluorodeoxyglucose positron-emission mammography in the surgical management of breast cancer.
BACKGROUND
High-resolution positron-emission mammography (PEM) is a new device, which allows the imaging of breast tissue. A prospective study was performed to assess the accuracy of PEM in newly diagnosed breast cancer patients.


METHODS
In a prospective multicenter study, 44 women with confirmed breast cancers were imaged with a high-resolution PEM scanner (Naviscan PET Systems, Rockville, MD) with 18F-fluorodeoxyglucose. The images were blindly evaluated and were compared with final pathology.


RESULTS
The majority of the index lesions were seen on PEM (89%, 39/44). PEM detected 4 of 5 incidental breast cancers, 3 of which were not seen by any other imaging modalities. Of 19 patients undergoing breast-conserving surgery, PEM correctly predicted 6 of 8 (75%) patients with positive margins and 100% (11/11) with negative margins.


CONCLUSIONS
The current PEM device shows promise in detecting breast malignancies and may assist in the planning of adequate partial mastectomy procedures to better ensure negative margins.
Tafra
Lorraine
L
The Breast Center, Anne Arundel Health Systems, 2002 Medical Parkway, Suite 120, Annapolis, MD 21401, USA. ltafra@aahs.org
Cheng
Zandra
Z
Uddo
Joseph
J
Lobrano
Mary B
MB
Stein
William
W
Berg
Wendie A
WA
Levine
Edward
E
Weinberg
Irving N
IN
Narayanan
Deepa
D
Ross
Eric
E
Beylin
David
D
Yarnall
Stephen
S
Keen
Rochelle
R
Sawyer
Kristen
K
Van Geffen
Jack
J
Freimanis
Rita L
RL
Staab
Edward
E
Adler
Lee P
LP
Lovelace
Judy
J
Shen
Perry
P
Stewart
John
J
Dolinsky
Sergei
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D016037:Single-Blind Method
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18