title: Granulocytic sarcoma manifesting as multiple skeletal lesions.
abstract: Granulocytic sarcoma is an extramedullary collection of myeloblasts that is usually associated with acute or chronic myeloid leukemia. It can be found in any location throughout the body; however, multifocal skeletal involvement is extremely rare. This report describes a case of granulocytic sarcoma in a 33-year-old man, manifesting as multiple skeletal lesions along with signs of cord compression without any preceding history of myeloid leukemia. Cytogenetic studies revealed t(8,9) translocation, which has never been reported in association with granulocytic sarcoma. The prognostic significance of this finding is unknown. This case report underscores the importance of considering granulocytic sarcoma in the differential diagnosis of spinal tumors, since the tumor may occur before other manifestations of myeloid leukemia are evident.
authors.affiliation: Department of Internal Medicine, University of Oklahoma Health Sciences Center and the Section of Hematology-Oncology, OU Cancer Center, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hamadani
authors.forename: Arafat
authors.initials: A
authors.lastname: Tfayli
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sethi
authors.forename: Ahmed
authors.initials: A
authors.lastname: Awab
authors.forename: Najma
authors.initials: N
authors.lastname: Hamdani
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D011379:Prognosis; D011877:Radionuclide Imaging; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology* / Q000628:therapy
chemical_list: D009195:Peroxidase