Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein.
An artificial phospholipid, possessing saturated alkyl chains as a membrane anchor and protein recognition site as well as an Fe(III)-EDTA moiety as a protein cleavable polar head group, was designed and synthesized based on the amidite method for the purpose of examination of cleavage of integral membrane proteins.
Furuta
Takumi
T
Department of Synthetic Organic and Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
Sakai
Minatsu
M
Hayashi
Hiroyasu
H
Asakawa
Tomohiro
T
Kataoka
Fumi
F
Fujii
Satoshi
S
Suzuki
Takashi
T
Suzuki
Yasuo
Y
Tanaka
Kiyoshi
K
Fishkin
Nathan
N
Nakanishi
Koji
K
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D006388:Hemagglutinins; D007202:Indicators and Reagents; D007502:Iron Chelating Agents / Q000737:chemistry; D008051:Lipid Bilayers; D008279:Magnetic Resonance Imaging; D008565:Membrane Proteins / Q000737:chemistry*; D010743:Phospholipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000737:chemistry
D006388:Hemagglutinins; D007202:Indicators and Reagents; D007502:Iron Chelating Agents; D008051:Lipid Bilayers; D008565:Membrane Proteins; D010743:Phospholipids; D000509:alpha-Fetoproteins