title: Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase.
abstract: Inhibitors of mammalian ribonucleotide reductase possessing a novel octahydropyranopyrrole scaffold based on a cyclic heptapeptide inhibitor have been designed, synthesized, and evaluated. Structure-function studies reveal that the bicyclic scaffold is indeed necessary to maintain inhibitory activity.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Fuertes
authors.forename: Jaskiran
authors.initials: J
authors.lastname: Kaur
authors.forename: Prasant
authors.initials: P
authors.lastname: Deb
authors.forename: Barry S
authors.initials: BS
authors.lastname: Cooperman
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D000818:Animals; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D011714:Pyrans; D011758:Pyrroles; D012264:Ribonucleotide Reductases