title: Infectious keratitis after overnight orthokeratology in Canada.
abstract: OBJECTIVE
  To report 3 cases of infectious keratitis related to overnight orthokeratology use.
  
  
  METHODS
  Retrospective case observation.
  
  
  RESULTS
  All 3 patients were using overnight orthokeratology lenses when they presented with unilateral corneal ulcers. The organisms isolated were Acanthamoeba, Pseudomonas aeruginosa, and Serratia marcescens. The clinical presentation and treatment of each case is presented.
  
  
  CONCLUSIONS
  Overnight orthokeratology use may be associated with infectious keratitis despite the use of more oxygen-permeable materials and improved lens design. Patient education with informed consent, appropriate lens care, and meticulous follow-up is important. Because this complication is potentially sight threatening, orthokeratology requires further analysis and evaluation to establish its safety. The cases here are the first few reported cases in North America.
authors.affiliation: Department of Ophthalmology and Vision Science, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Natasha
authors.initials: N
authors.lastname: Yepes
authors.forename: Sao-Bing
authors.initials: SB
authors.lastname: Lee
authors.forename: Vivian
authors.initials: V
authors.lastname: Hill
authors.forename: Mike
authors.initials: M
authors.lastname: Ashenhurst
authors.forename: Patrick P R
authors.initials: PP
authors.lastname: Saunders
authors.forename: Allan R
authors.initials: AR
authors.lastname: Slomovic
mesh_terms: D015823:Acanthamoeba Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002170:Canada; D002648:Child; D018639:Contact Lens Solutions; D003261:Contact Lenses / Q000009:adverse effects* / Q000382:microbiology / Q000469:parasitology; D003315:Cornea / Q000382:microbiology / Q000469:parasitology; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012030:Refractive Errors / Q000628:therapy; D012189:Retrospective Studies; D016868:Serratia Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012706:Serratia marcescens / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D018639:Contact Lens Solutions