title: Dynamic contrast-enhanced MRI in the differentiation of posttreatment fibrosis from recurrent carcinoma of the head and neck.
abstract: OBJECTIVE
  The aim of this study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (MRI) in the differentiation of posttreatment fibrosis from recurrent carcinoma, by comparing the dynamic contrast-enhancement characteristics of the lesions.
  
  
  METHODS
  Twenty-six patients with previously treated carcinoma of the head and neck are studied by conventional and dynamic contrast-enhanced MRI at least 6 months after treatment by radiotherapy and/or surgery. Patients are divided into tumor-positive or -negative groups according to the radiological and clinical follow-up and biopsy. Lesion enhancement ratios at each dynamic sequence are calculated.
  
  
  RESULTS
  The tumor-positive group consisted of 11 patients, while the tumor-negative group included 15 patients. Between the two groups, lesion enhancement ratios are found to be significantly different (P<.05).
  
  
  CONCLUSIONS
  Dynamic contrast-enhanced MRI may be a valuable modality in the differentiation of recurrent tumor from posttreatment fibrotic changes of the head and neck.
authors.affiliation: Department of Radiology, Hospital Turk, Istanbul, Turkey. aslihansemiz@yahoo.com
authors.forename: Aslihan
authors.initials: A
authors.lastname: Semiz Oysu
authors.forename: Elif
authors.initials: E
authors.lastname: Ayanoglu
authors.forename: Nihat
authors.initials: N
authors.lastname: Kodalli
authors.forename: Cagatay
authors.initials: C
authors.lastname: Oysu
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Uneri
authors.forename: Canan
authors.initials: C
authors.lastname: Erzen
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000628:therapy; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000175:diagnosis* / Q000209:etiology; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D003287:Contrast Media