title: Evaluation of adverse effects in intracarotid propofol injection for Wada test.
abstract: The authors evaluated adverse effects of intracarotid propofol injection during a Wada test and their risk factors in 58 patients. Nineteen patients had an adverse effect, mostly in patients receiving more than 10 mg. For patients older than age 55 years or those requiring an injection dose greater than 20 mg to produce hemiplegia, propofol should be injected slowly and patients monitored for excitatory movements.
authors.affiliation: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. mikunin@kuhp.kyoto-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Mikuni
authors.forename: M
authors.initials: M
authors.lastname: Takayama
authors.forename: T
authors.initials: T
authors.lastname: Satow
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Nishida
authors.forename: J
authors.initials: J
authors.lastname: Taki
authors.forename: R
authors.initials: R
authors.lastname: Enatsu
authors.forename: A
authors.initials: A
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Miyamoto
authors.forename: N
authors.initials: N
authors.lastname: Hashimoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D002648:Child; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000517:prevention & control; D005260:Female; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007269:Injections, Intra-Arterial / Q000009:adverse effects; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control*; D011300:Preoperative Care / Q000009:adverse effects*; D015742:Propofol / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D013060:Speech / Q000187:drug effects / Q000502:physiology
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol