Pisa syndrome without neuroleptic exposure in a patient with Parkinson's disease: case report.
We report on a patient affected by Parkinson's disease who developed over a period of a few weeks a tonic deviation of her head, neck, and trunk fitting the typical description of Pisa syndrome (PS). This patient was under stable levodopa and pramipexole treatment and had never been exposed to any psychotropic or antiemetic drugs before or at the time she developed the postural abnormality. Because dopamine transporter imaging revealed bilateral and symmetrical reduction of striatal uptake, we suggest that PS is not primarily related to side differences in dopaminergic denervation or drug exposure.
Gambarin
Mattia
M
Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Università di Verona, Verona, Italy.
Antonini
Angelo
A
Moretto
Giuseppe
G
Bovi
Paolo
P
Romito
Silvia
S
Fiaschi
Antonio
A
Tinazzi
Michele
M
D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D002540:Cerebral Cortex / Q000503:physiopathology; D003342:Corpus Striatum / Q000503:physiopathology; D050483:Dopamine Plasma Membrane Transport Proteins / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004422:Dystonia Musculorum Deformans / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage* / Q000009:adverse effects; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D013577:Syndrome; D015899:Tomography, Emission-Computed, Single-Photon
D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D007980:Levodopa