title: New approach of the treatment of von Willebrand's disease during pregnancy.
abstract: OBJECTIVE
  The aim of the study was to analyze the effectiveness of the application of DDAVP (desmopressin) and Hemate P with cryoprecipitate pre- and postpartum in patients with von Willebrand disease.
  
  
  METHODS
  We monitored 32 patients with von Willebrand disease during the study period 1993-2003. DDAVP was applied in the 36th/37th week of gestation and cryoprecipitate and fresh frozen plasma were applied 1 day before and 3 days after delivery. DDAVP treatment continued for 4 weeks. Factor VIII (Hemate P) at the day of delivery
  
  
  RESULTS
  No complications occurred in the studied population.
  
  
  CONCLUSIONS
  Precipitation of DDAVP, Hemate P, and cryoprecipitate may help in the treatment of pregnant women with von Willebrand disease.
authors.affiliation: Medical Faculty Belgrade, Institute of Gynecology and Obstetrics, Clinical Center of Serbia, University of Belgrade, 38 Milesevska Street, 11000, Belgrade, Serbia and Montenegro. gojagoya@EUnet.yu
authors.forename: Miroslava
authors.initials: M
authors.lastname: Gojnic
authors.forename: A
authors.initials: A
authors.lastname: Fazlagic
authors.forename: I
authors.initials: I
authors.lastname: Likic
authors.forename: A
authors.initials: A
authors.lastname: Stefanovic
authors.forename: S
authors.initials: S
authors.lastname: Vidakovic
authors.forename: M
authors.initials: M
authors.lastname: Pervulov
authors.forename: S
authors.initials: S
authors.lastname: Petkovic
authors.forename: T
authors.initials: T
authors.lastname: Mostic
authors.forename: P
authors.initials: P
authors.lastname: Miljic
authors.forename: A
authors.initials: A
authors.lastname: Bogdanovic
mesh_terms: D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D036861:Delivery, Obstetric / Q000379:methods; D005169:Factor VIII / Q000008:administration & dosage / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000008:administration & dosage / Q000032:analysis; D005865:Gestational Age; D006490:Hemostatics / Q000008:administration & dosage; D006801:Humans; D010314:Partial Thromboplastin Time; D049590:Postpartum Period; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000628:therapy*; D011517:Prothrombin Time; D014842:von Willebrand Diseases / Q000097:blood / Q000188:drug therapy / Q000628:therapy*
chemical_list: D006490:Hemostatics; C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen; D003894:Deamino Arginine Vasopressin