[Viral vectors in gene therapy. Advantages of the adenoassociated vectors].
Gene therapy has evolved due to the development of a number of biotechnology weapons, i.e., vectors that achieve for a longer expression and safer administration. Among viral vectors developed adeno-associated virus have shown promising advantages. These DNA viruses transduce a wide cell range, can integrate in host's genome and achieve for a long-period expression, besides avoiding a cellular immune response. The new technologies applied to the production and purification of these vectors had resulted in notable increases in quantity and quality of the infectious particles obtained. Actually, due to biotechnological advances, gene therapy is a potential therapeutic option.
Sandoval Rodríguez
Ana Soledad
AS
Instituto de Biología Molecular en Medicina y Terapia Génica. CUCS. Universidad de Guadalajara CA-77.
Salazar Montes
Adriana María
AM
Armendáriz-Borunda
Juan
J
D000256:Adenoviridae; D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D016086:Lentivirus; D008107:Liver Diseases / Q000628:therapy; D012190:Retroviridae