title: [Single photon emission computed tomography findings in a case of alternating hemiplegia of childhood in relation to migraine].
abstract: Single photon emission computed tomography (SPECT) was performed 3 times during attacks and performed 4 times during postictal periods on a case of alternating hemiplegia of childhood. Hyperperfusion of the corresponding hemisphere to hemiparesis was suggested by asymmetric increase RI uptake during the ictal scans, whereas interictal scans showed symmetric topography of cerebral blood flow. Manifestations except hemiplegia included loss of consciousness and vomiting. These manifestations and ictal SPECT findings are the same evidence as hemiplegic migraine. It suggests that these two disorders have a similar pathophysiology. There are two interesting findings regarding this patient. The first finding is magnetic resonance imaging showed progressive cerebellar atrophy. Second finding is interictal SPECT showed a progressive decrease of cerebral perfusion, especially in cerebellar hemispheres. These two findings suggest alternating hemiplegia of childhood may be a chronic progressive disorder.
authors.affiliation: Division of Neurology, Saitama Children's Medical Center, Iwatsuki, Saitama.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yamashita
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Hamano
authors.forename: Manabu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshinari
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Minamitani
authors.forename: Mika
authors.initials: M
authors.lastname: Hayakawa
mesh_terms: D001284:Atrophy; D002531:Cerebellum / Q000473:pathology; D002648:Child; D003545:Cysteine / Q000031:analogs & derivatives; D004569:Electroencephalography; D006429:Hemiplegia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008279:Magnetic Resonance Imaging; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D020367:Iofetamine; C059659:technetium Tc 99m bicisate; D003545:Cysteine