title: [Presence and significance of HBV in renal tissues from patients with HBV infection].
abstract: OBJECTIVE
  To investigate the presence and significance of HBsAg, HBcAg, and HBV DNA in renal tissues from patients with HBV infection.
  
  
  METHODS
  The presences of HBsAg and HBcAg were measured in the renal tissues of 63 patients with HBV associated glomerulonephritis (HBV-GN), 20 patients with non-HBV associated glomerulonephritis (NHBV-GN), and 12 other renal patients with positive HBV markers (such as renal tuberculosis, renal calculi, renal cellular carcinoma, and renal atrophy, and so on) by immunocytochemistry. HBV DNA was detected in the renal tissues of those patients with positive immunocytochemic results by polymerase chain reaction (PCR).
  
  
  RESULTS
  HBsAg and HBcAg were present with the positive rates of 76.2% and 42.9% respectively in the renal tissues of HBV-GN patients, which were significantly higher than those of NHBV-GN patients, but had no statistical difference compared with those of other renal patients with positive HBV markers. The positive expression rates of HBsAg and HBcAg in renal tissues showed no statistically significant difference between HBV-GN patients with positive serum HBeAg and HBV-GN patients with negative serum HBeAg. By PCR, 13 out of 17 HBV-GN patients (76.5%) were positive, and 2 out of 8 patients with other renal diseases (25%) were positive.
  
  
  CONCLUSIONS
  The location of HBV in the renal tissues may lead to renal lesions, and it plays a role in the replication, the preservation of virus, and the transmission of hepatitis B.
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China. Diaveliz_cn@sina.com
authors.forename: Li-Zhang
authors.initials: LZ
authors.lastname: Chen
authors.forename: Xue-Gong
authors.initials: XG
authors.lastname: Fan
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000821:virology*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000302:isolation & purification* / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000150:complications / Q000821:virology*; D006801:Humans; D007668:Kidney / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens