Long-term prevention of skeletal complications by pamidronate in a patient with bone metastasis from endometrial carcinoma: a case report.
BACKGROUND
Bisphosphonates are an effective treatment for bone metastases from breast cancer. However, it is unclear whether they are effective for bone metastases from endometrial carcinoma.


METHODS
A 70-year-old woman previously treated for endometrial carcinoma was referred to our hospital due to osteolytic destruction of the left ischial tuberosity. Technetium-99m-HMDP bone scintigraphy revealed abnormal uptake in the ischium. Biopsy revealed a metastatic bone tumor, but computed tomography scans did not show general metastatic spread. The patient received intravenous administration of pamidronate and three cycles of chemotherapy (epirubicin + paclitaxel + carboplatin). Three years later, the bone lesion showed prominent sclerotic changes with no evidence of disease recurrence radiologically.


CONCLUSIONS
Pamidronate may prevent skeletal complications in selected patients with bone metastasis due to endometrial carcinoma.
Osanai
Toshihisa
T
Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. osanait@med.id.yamagata-u.ac.jp
Tsuchiya
Takashi
T
Ogino
Toshihiko
T
Nakahara
Kenji
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D016190:Carboplatin / Q000008:administration & dosage; D004164:Diphosphonates / Q000627:therapeutic use*; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000473:pathology*; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage; D000077268:Pamidronate
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D015251:Epirubicin; D016190:Carboplatin; D000077268:Pamidronate; D017239:Paclitaxel