title: Treatment of solid tumors with immunotoxins.
abstract: Immunotoxins are hybrid molecules that generally consist of a toxin coupled with a tumor-specific antibody or antibody fragment that is intended to target and concentrate the toxin within the tumor tissue. The biodistribution, specificity, immunogenicity, and cytotoxic activity of the immunotoxin are but a few of the factors that govern the effectiveness of these compounds in the treatment of patients with cancer. Improvements in design, synthesis, and delivery of these molecules may permit them to become significant components in the arsenal of targeted therapies for cancer.
authors.affiliation: Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
authors.forename: Davorka
authors.initials: D
authors.lastname: Messmer
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kipps
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000922:Immunotoxins