Histological examinations of chief and parietal cells of the rat gastric glands after experimental administration of cephalexin and ethanol.
The experiment was carried out on Wistar rat males weighting about 200 g. Animals from experimental group I received 20% ethanol for drinking (ad libitum), animals from experimental group II--cephalexin in the dose of 42 mg/24 h, animals from experimental group III--cephalexin and ethanol in mentioned doses. After 10 days animals were decapitated and specimens of the stomach were taken from the greater curvature. It was stated that 10-day administration of 20% ethanol causes hyperemia of the gastric mucous membrane and the decrease of secretory activity of the glands. On the contrary, cephalexin causes the increase of secretory activity of chief and parietal cells. Concomitant administration of ethanol and cephalexin damages the gastric mucous membrane causing its narrowing, flattening of gastric pits and atrophy of secretory cells in the glands.
Zarebska
Alicja
A
Department of Histology and Embryology, Laboratory of Experimental Cytology, Skubiszewski Medical University of Lublin.
Sekita-Krzak
Joanna
J
Hernik
Daria
D
Matusiewicz
Janusz
J
Czerny
Krystyna
K
D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001284:Atrophy / Q000473:pathology; D002452:Cell Count; D002506:Cephalexin / Q000633:toxicity*; D019872:Chief Cells, Gastric / Q000187:drug effects* / Q000473:pathology; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010295:Parietal Cells, Gastric / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D000431:Ethanol; D002506:Cephalexin