title: Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome.
abstract: The objective of this study was to evaluate the clinical and reproductive outcome in clomiphene-citrate (CC)-resistant women with high body mass index (BMI) and primary infertility. This was a case series based at the King Hussein Medical center, Amman, Jordan. Nineteen CC-resistant women with polycystic ovary syndrome (PCOS) who had high BMI and primary infertility were studied. All women received metformin monotherapy; 850 mg twice daily for a period of 6 months. If pregnancy occurred, metformin was continued for the first 12 weeks of pregnancy. The main outcome measures were a reduction in the BMI, resumption of regular menses, ovulation and pregnancy rates. Resumption of regular cycles was observed in 13 of 19 (68.4%) women. Ovulation and pregnancy were achieved in 9 (47.4%) and 6 (31.6%) of the 19 women, respectively. A significant reduction in the body weight after treatment reflected by a significant reduction in the BMI was noted. Metformin monotherapy is effective in CC-resistant women with morbid obesity and primary infertility and should be considered as first-line treatment in these patients.
authors.affiliation: Department of Obstetrics and Gynaecology, Infirtility clinic, Royal Medical Service, King Hussein Medical Center, Amman, Jordan. hqublan@yahoo.com
authors.forename: H S
authors.initials: HS
authors.lastname: Qublan
authors.forename: H Y
authors.initials: HY
authors.lastname: Malkawi
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002996:Clomiphene; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007247:Infertility, Female / Q000628:therapy*; D008687:Metformin / Q000008:administration & dosage*; D009765:Obesity / Q000150:complications* / Q000188:drug therapy; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D007004:Hypoglycemic Agents; D002996:Clomiphene; D008687:Metformin