title: Coding and noncoding genomic regions of Entamoeba histolytica have significantly different rates of sequence polymorphisms: implications for epidemiological studies.
abstract: To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.
authors.affiliation: Department of Microbiology and Immunology, Division of Infectious Diseases, Stanford, CA 94305, USA.
authors.forename: Dhruva
authors.initials: D
authors.lastname: Bhattacharya
authors.forename: Rashidul
authors.initials: R
authors.lastname: Haque
authors.forename: Upinder
authors.initials: U
authors.lastname: Singh
mesh_terms: D000818:Animals; D004748:Entamoeba histolytica / Q000145:classification* / Q000235:genetics; D004749:Entamoebiasis / Q000453:epidemiology* / Q000469:parasitology; D016021:Epidemiologic Studies; D005260:Female; D014644:Genetic Variation; D018503:Genome, Protozoan; D005838:Genotype; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D022661:RNA, Untranslated