title: [Impact of iodination on the total mutagenic activity of chlorinated tap water].
abstract: The impact of iodination on the total mutagenic activity (TMA) of chlorinated tap water was studied. Iodination was made, by using iodine in doses of 0.5 to 4.0 mg/l on an experimental unit at pH 7.3-7.5 for 30 min. Organic water pollutants were concentrated, by using the polymer sorbent Separon SE. The mutagenic activity of water concentrates was evaluated in the Ames test using the strains Salmonella TA 100 and TA 98 both in the presence and in the absence of the metabolic activation system. Iodination substantially reduced the TMA of chlorinated tap water. The minimally effective dose of iodine against the TMA of chlorinated tap water was 1 mg/l, as evidenced by the tests using all the strains/variants and 0.5 mg/l, as shown by the tests using the strain TA 100 in the variant without metabolic activation.
authors.forename: L V
authors.initials: LV
authors.lastname: Akhal'tseva
authors.forename: V S
authors.initials: VS
authors.lastname: Zhukov
authors.forename: L F
authors.initials: LF
authors.lastname: Kir'ianova
authors.forename: E V
authors.initials: EV
authors.lastname: Neiaskina
authors.forename: I N
authors.initials: IN
authors.lastname: Ryzhova
authors.forename: E M
authors.initials: EM
authors.lastname: Sevost'ianova
mesh_terms: D002713:Chlorine / Q000009:adverse effects* / Q000032:analysis; D015169:Colony Count, Microbial; D066298:In Vitro Techniques; D007455:Iodine / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000009:adverse effects / Q000032:analysis; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D014867:Water / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply
chemical_list: D009153:Mutagens; D014874:Water Pollutants, Chemical; D014867:Water; D002713:Chlorine; D007455:Iodine