The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin.
OBJECTIVE
To explore the correlation of nonalcoholic fatty liver (NAFL) with insulin resistance and the intervention of it by Gankangyin(GKY).


METHODS
Ninety-six patients with NAFL were randomly assigned into the treated group and the control group. They were treated with GKY and Silymarin for 3 months respectively. Oral glucose tolerance test (OGTT) and insulin release test (IRT) were conducted and insulin sensitivity indexes were determined before and after treatment. And 32 healthy nonalcoholic persons were enrolled and used as the healthy control group.


RESULTS
Before treatment, the levels of blood glucose and insulin at different time points in OGTT test, and the insulin resistance index (IRI) were significantly higher (P < 0.05 or P < 0.01) while insulin sensitivity index (ISI) and insulin active index (IAI) were lower (P < 0.05 or P < 0.01) in the NAFL patients than those in the healthy persons. After treatment, the above-mentioned raised criteria were significantly lowered (P < 0.05, P < 0.01) and the lowered criteria were significantly increased (P < 0.01) in the treated group, while in the control group all the criteria were insignificantly changed (P > 0.05).


CONCLUSIONS
Evident insulin resistance exists in NAFL patients. GKY could increase the insulin sensitivity, thus improving the state of insulin resistance in NAFL patients.
Deng
Yin-quan
YQ
The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou. deyq@tom.com
Fan
Xiao-fen
XF
Li
Jian-ping
JP
D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000975:Antioxidants / Q000008:administration & dosage; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005234:Fatty Liver / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012838:Silymarin / Q000008:administration & dosage; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007328:Insulin; D012838:Silymarin; D014280:Triglycerides; D002784:Cholesterol; D000410:Alanine Transaminase