[The effects of recombinant human growth hormone on mandibular bone loss with or without teeth in the ovariectomized rats].
OBJECTIVE
To investigate the effects of recombinant human growth hormone(rh-GH )on mandibular bone loss with or without teeth in the ovariectomized rats.


METHODS
Three-month aged ovariectomized rats were utilized as postmenopausal osteoporosis models and all the molars in left mandibles were extracted. After operations, the rats began to receive rh-GH 1 mg.kg(-1).d(-1) with subcutaneous injection for ten days. Weight of the rats ,mineral density of the mandibular bone and 3 other parameters were measured at 8th week and 12th week. The data was analyzed with F and t test.


RESULTS
The weight of the rats increased and mandibular bone mineral density of the rats were significantly improved after rh-GH treatment, P<0.05.


CONCLUSIONS
Rh-GH can increase the weight of the old rats and restore mandibular bone mass in mandibles with or without teeth.
Wang
Xu-xia
XX
School of Stomatology, Shandong University, Jinan 250012, Shandong Province, China.
Zhang
Jun
J
Zhao
Zuo-Qin
ZQ
Xing
Da-yuan
DY
Chen
Lei
L
D000818:Animals; D015519:Bone Density; D005260:Female; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D008334:Mandible / Q000187:drug effects*; D008963:Molar; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D010052:Ovariectomy; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology
D011994:Recombinant Proteins; D019382:Human Growth Hormone