Adenocarcinoma ex pleomorphic adenoma of the head and neck: Report of five cases.
OBJECTIVE
Adenocarcinoma ex pleomorphic adenoma is a rare tumor, and thus the management of the tumor has not been established.


METHODS
The retrospective review of the clinical records at Okayama University was performed.


RESULTS
We present five cases of adenocarcinoma ex pleomorphic adenoma of the head and neck, including a rare case with nasopharyngeal adenocarcinoma ex pleomorphic adenoma. There was no response to chemotherapy with nedaplatin and 5-FU, but the nasopharyngeal adenocarcinoma ex pleomorphic adenoma showed a remarkable regression after the administration of docetaxel.


CONCLUSIONS
The combination therapy that includes docetaxel may be a promising treatment for adenocarcinoma ex pleomorphic adenoma of the head and neck.
Kariya
Shin
S
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Okayama 700-8558, Japan. skariya@cc.okayama-u.ac.jp
Kosaka
Michiya
M
Orita
Yorihisa
Y
Akagi
Hirofumi
H
Nishizaki
Kazunori
K
D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000077143:Docetaxel; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010159:Palate / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology; D012189:Retrospective Studies; D043823:Taxoids / Q000008:administration & dosage
D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; C053989:nedaplatin; D005472:Fluorouracil