The Elegance of the MicroRNAs: A Neuronal Perspective.
As knowledge of microRNAs (miRNA) grows from a compendium of sequences to annotated functional data it has become increasingly clear that a highly significant segment of regulatory biology depends on these approximately 22 nucleotide noncoding transcripts. The expression of many miRNAs in the nervous system, some with a high degree of temporal and spatial specificity, suggests that understanding miRNAs in the nervous system will yield rewarding neurobiological insights. High on the list of insights that microRNAs promise is a deeper understanding of the remarkable cellular diversity found among neurons. This review examines the interface between an emerging biology of miRNAs and their role in nervous systems.
Kosik
Kenneth S
KS
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA. kosik@lifesci.ucsb.edu
Krichevsky
Anna M
AM
D000818:Animals; D035683:MicroRNAs / Q000502:physiology*; D009420:Nervous System / Q000166:cytology*; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000502:physiology*
D035683:MicroRNAs