title: Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula.
abstract: Axinelloside A was isolated from the lipophilic extract of the Japanese marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC(50) 2.0 microg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Warabi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hamada
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakao
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirota
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002247:Carbon Isotopes; D006367:HeLa Cells; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D011522:Protons; D012015:Reference Standards; D013237:Stereoisomerism; D013431:Sulfates / Q000737:chemistry*; D019098:Telomerase / Q000037:antagonists & inhibitors*
chemical_list: D002247:Carbon Isotopes; D008070:Lipopolysaccharides; D011134:Polysaccharides; D011522:Protons; D013431:Sulfates; C505704:axinelloside A; D019098:Telomerase