[Nitric oxide and cardiologic drugs].
The influence of simvastatin and metoprolol on nitric oxide synthesis (measured as NO metabolites plasma concentration) was studied. Results. It was revealed that both simvastatin and metoprolol diminish significantly plasma nitric oxide concentration by 24.6% and 23.7% respectively. It was also compared nitric oxide concentrations in plasma of rabbits, after 3 week of mononitrate isosorbitol and molsidomine administration--assuming that applied doses are relevant to maximal doses applied to the human. It was found that molsidomine releases more nitric oxide than mononitrate isosorbitol.
Kopff
Maria
M
Uniwersytet Medyczny w Lodzi, Zakład Chemii i Biochemii Klinicznej.
Kowalczyk
Edward
E
Kopff
Anna
A
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D045462:Endothelium-Dependent Relaxing Factors / Q000494:pharmacology; D007547:Isosorbide / Q000494:pharmacology*; D008790:Metoprolol / Q000494:pharmacology*; D008981:Molsidomine / Q000494:pharmacology*; D009569:Nitric Oxide / Q000097:blood*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D011817:Rabbits; D019821:Simvastatin / Q000494:pharmacology*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000924:Anticholesteremic Agents; D002317:Cardiovascular Agents; D045462:Endothelium-Dependent Relaxing Factors; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D019821:Simvastatin; D008981:Molsidomine; D008790:Metoprolol; D007547:Isosorbide