title: Association of MHC class I chain related gene-A microsatellite polymorphism with the susceptibility to T1DM and LADA in Czech adult patients.
abstract: The results in this study suggest that microsatellite polymorphism within the transmembrane region of MIC-A gene is associated with genetic susceptibility to adult-onset of type 1 diabetes mellitus (T1DM), MIC-A5.1 allele, corrected P = 0.001, whereas it is not associated with latent autoimmune diabetes in adults (LADA) in Czech population. According to our findings, we can hypothesize that adult-onset T1DM and LADA may have partly different immunogenetic aetiopathogenesis.
authors.affiliation: Department of Cell and Molecular Biology, the 3rd Faculty of Medicine, Charles University, Ruská 87, 100 21 Prague 10, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Novota
authors.forename: K
authors.initials: K
authors.lastname: Kolostova
authors.forename: D
authors.initials: D
authors.lastname: Pinterova
authors.forename: J
authors.initials: J
authors.lastname: Novak
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: L
authors.initials: L
authors.lastname: Treslova
authors.forename: J
authors.initials: J
authors.lastname: Kovar
authors.forename: M
authors.initials: M
authors.lastname: Andel
authors.forename: M
authors.initials: M
authors.lastname: Cerna
mesh_terms: D000328:Adult; D018153:Czech Republic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A