title: [Surveillance of antimicrobial resistance of Streptococcus pneumoniae isolates from the Kinki Region of Japan during 2003/2004. The Surveillance Program of Bacterial Resistance in the Kinki Region of Japan; SBRK].
abstract: Three hundred seventy five isolates of Streptococcus pneumoniae were collected from 14 medical institutions in the Kinki region of Japan between November 2003 and February 2004. We determined the minimum inhibitory concentration (MIC) of penicillin G (PCG) and 25 of other antimicrobial agents against these isolates according to the National Committee for Clinical Laboratory Standards (NCCLS). Overall, 71.5% of all isolates were resistant to PCG (intermediate and resistant categories were 51.7% and 19.8%, respectively). For the carbapenems and penem, the rank order of activity was PAPM (MIC90, 0.12 microg/ml) > IPM (0.25 microg/ml) > MEPM (0.5 microg/ml) = FRPM (0.5 microg/ml). For the cephems, the overall rank order of activity was CPR (MIC90, 0.5 microg/ml) = CDTR (0.5 microg/ml) > CTRX (1 microg/ml) = CTX (1 microg/ml) = CZOP (1 microg/ml) = CFPN (1 microg/ml). Rank order activity for six of fluoroquinolones was TFLX = MFLX (MIC90, 0.25 microg/ml) > GFLX (0.5 microg/ ml) = SPFX (0.5 microg/ml) > LVFX (1 microg/ml) > PZFX (4 microg/ml). The rate of resistance to fluoroquinolones per the NCCLS criteria were very low, ranging from 0.7% to 2.6%. Rate of resistance to other antimicrobiotics were CAM, 77.0%; CLDM, 41.7%; TEL, 0%; VCM, 0%; ST, 32.7%, and CP, 21.4%.
authors.affiliation: Department of Clinical Laboratory, Kinki University Hospital.
authors.forename: Kaori
authors.initials: K
authors.lastname: Satoh
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sueyoshi
authors.forename: Masaru
authors.initials: M
authors.lastname: Komatsu
authors.forename: Koichi
authors.initials: K
authors.lastname: Shimakawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Toyokawa
authors.forename: Isao
authors.initials: I
authors.lastname: Nishi
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Nishio
authors.forename: Masako
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Tomonari
authors.initials: T
authors.lastname: Yamashita
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Okamoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Chizuru
authors.initials: C
authors.lastname: Nomura
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Wada
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ono
authors.forename: Tamaki
authors.initials: T
authors.lastname: Orita
authors.forename: Shohiro
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Tomomi
authors.initials: T
authors.lastname: Koufuku
mesh_terms: D024881:Drug Resistance, Bacterial; D006801:Humans; D007564:Japan; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification