title: Evaluation of ascorbic acid as suppressor of cyclophosphamide induced lipid peroxidation using common laboratory markers.
abstract: The present study deals with exploration of lipid peroxidation induction capacity of cyclophosphamide, an anticancer drug, and in vitro evaluation of ascorbic acid as a suppressor of cyclophosphamide induced lipid peroxidation. Goat liver homogenate has been used as the lipid source. This evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of the tissue as markers of lipid peroxidation. The study revealed that ascorbic acid could suppress the drug induced lipid peroxidation to a significant extent.
authors.affiliation: Division of Medicinal & Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.
authors.forename: Supratim
authors.initials: S
authors.lastname: Ray
authors.forename: Chandana
authors.initials: C
authors.lastname: Sengupta
authors.forename: Kunal
authors.initials: K
authors.lastname: Roy
mesh_terms: D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D003520:Cyclophosphamide / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D005978:Glutathione / Q000378:metabolism; D006041:Goats; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D013997:Time Factors
chemical_list: D000447:Aldehydes; D018906:Antineoplastic Agents, Alkylating; D000975:Antioxidants; D015415:Biomarkers; D009569:Nitric Oxide; D008315:Malondialdehyde; D003520:Cyclophosphamide; D005978:Glutathione; C027576:4-hydroxy-2-nonenal; D001205:Ascorbic Acid