title: Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection.
abstract: To determine the role of host immune responses in H. pylori infection, we examined the relationship between gastric mucosal IL-8 levels and histological gastritis in patients with H. pylori infection. Biopsy tissue obtained from 99 patients were homogenizedand mucosal IL-8 levels measured by ELISA. The gastric mucosal IL-8 levels in both the antrum and corpus were higher in patients with H. pylori than in H. pyloi negativepatients. IL-8 levels in the corpus but not the antrum correlated with the severity of the atrophy. The IL-1B polymorphism had no influence on the degree of IL-8 production. These findings indicate that IL-8 production is independent of IL-1B polymorphisms and IL-8 may play an important role in the development of atrophic gastritis.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: Jiang
authors.initials: J
authors.lastname: Xuan
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Deguchi
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yanagi
authors.forename: Hideki
authors.initials: H
authors.lastname: Ozawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Urano
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Ryuuki
authors.initials: R
authors.lastname: Fukuda
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kojima
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishina
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sudo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Koga
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takagi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration / Q000276:immunology; D011110:Polymorphism, Genetic
chemical_list: D007375:Interleukin-1; D016209:Interleukin-8