Effects of chitin/chitosan and their oligomers/monomers on release of type I collagenase from fibroblasts.
The effects of chitin/chitosan and their oligomers/monomers on the release of type I collagenase (MMP-1) from fibroblasts were evaluated using adult (adFB) and neonatal human fibroblasts (neFB) by a immunological assay. Release of MMP-1 from adFB increased significantly or tended to increase for all samples, while there was no significant change in MMP-1 levels with neFB. Because the oligomers and monomers of chitin and chitosan influenced MMP-1 activity, it was suggested that the elevated MMP-1 activity would continue until biodegradation of chitin and chitosan was complete.
Okamura
Yasuhiko
Y
Department of Veterinary Clinical Medicine, Faculty of Agriculture, Tottori University, Tottori-shi, Tottori 680-8553, Japan.
Nomura
Akio
A
Minami
Saburo
S
Okamoto
Yoshiharu
Y
D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D002686:Chitin / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D017364:Collagenases / Q000737:chemistry* / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism*; D014945:Wound Healing
D001672:Biocompatible Materials; D002686:Chitin; D048271:Chitosan; D017364:Collagenases; C417249:collagenase 1; D020781:Matrix Metalloproteinase 1