Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.
The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.
Vishweshwar
Peddy
P
Department of Chemistry, University of South Florida, SCA 400, 4202 E. Fowler Avenue, Tampa, Florida, USA. xtal@usf.edu.
McMahon
Jennifer A
JA
Peterson
Matthew L
ML
Hickey
Magali B
MB
Shattock
Tanise R
TR
Zaworotko
Michael J
MJ
D003460:Crystallization; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D018697:Nootropic Agents / Q000138:chemical synthesis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D010889:Piracetam / Q000138:chemical synthesis / Q000737:chemistry
D007202:Indicators and Reagents; D018697:Nootropic Agents; D004364:Pharmaceutical Preparations; D010889:Piracetam