[Influence of anxiogenic stress upon severity of alloxan-induced pancreatic and hepatic damage].
4 episodes of immobilization stress caused anxious and depressive behavioral disorder in rats, accompanied by decreased sensitivity of pancreatic tissue to alloxan-induced damage, and simultaneously increased sensitivity of hepatic tissue to alloxanogenic inflammatory effect. The latter shifts were accompanied by a more pronounced hyperglycemia. The paper discusses a probable role of hepatitis in hyperglycemic response to alloxan challenge associated with stressogenic anxiety.
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D000818:Animals; D001007:Anxiety / Q000150:complications* / Q000209:etiology*; D003921:Diabetes Mellitus, Experimental; D008107:Liver Diseases / Q000209:etiology* / Q000503:physiopathology; D010182:Pancreatic Diseases / Q000209:etiology* / Q000503:physiopathology; D051381:Rats; D013315:Stress, Psychological / Q000523:psychology*