title: Time and PSA threshold model prognosticates long-term overall and disease-specific survival in prostate cancer patients as early as 3 months after external beam radiation therapy.
abstract: The specific aim of this analysis was to evaluate the capability of a time and prostate-specific antigen (PSA) threshold model to prognosticate overall survival (OS) and disease-specific survival (DSS) based on early PSA kinetics after radiotherapy for prostate cancer by retrospective review of outcomes in 918 patients. Crossing below analyzed PSA thresholds at specific defined time points reduced disease-specific death hazard ratios to relative to the cohort above threshold. The time and PSA threshold model demonstrates the ability to prognosticate OS and DSS as early as 3 months post-radiotherapy for prostate cancer.
authors.affiliation: Departmnet of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 79936, USA. sean@drcavanaugh.com
authors.forename: S X
authors.initials: SX
authors.lastname: Cavanaugh
authors.forename: C D
authors.initials: CD
authors.lastname: Fuller
authors.forename: P A
authors.initials: PA
authors.lastname: Kupelian
authors.forename: C
authors.initials: C
authors.lastname: Reddy
authors.forename: P
authors.initials: P
authors.lastname: Bradshaw
authors.forename: B H
authors.initials: BH
authors.lastname: Pollock
authors.forename: M
authors.initials: M
authors.lastname: Fuss
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D017430:Prostate-Specific Antigen