title: Does psychological treatment help only those patients with severe irritable bowel syndrome who also have a concurrent psychiatric disorder?
abstract: OBJECTIVE
  We have previously reported improved health-related quality of life in patients with severe irritable bowel syndrome (IBS) following psychological treatments. In this paper, we examine whether this improvement was associated with improvement in psychological symptoms and was confined to those patients who had concurrent psychiatric disorder.
  
  
  METHODS
  Two hundred and fifty-seven patients with severe IBS entering a psychological treatment trial were interviewed using the Schedules for Clinical Assessment in Neuropsychiatry. At entry to the trial and 15 months later, patients were also assessed using the Hamilton Depression Rating Scale, Symptom Cheecklist-90 (SCL-90) and Short Form-36 (SF36) physical component summary score as the main outcome measure. Partial correlation was used to compare changes in SF36 score and changes in psychological scores while controlling for possible confounders, treatment group and baseline scores. Multiple regression analysis was used to examine whether changes in psychological scores, changes in pain and a history of abuse could account for most of the variance of change in SF36 physical component score.
  
  
  RESULTS
  Of 257 patients with severe IBS, 107 (42%) had a depressive, panic or generalized anxiety disorder at trial entry. There were moderate but significant correlations (0.21-0.47) between change in the psychological scores and the change in SF36 physical component scores. The correlation coefficients were similar in the groups with and without psychiatric disorder. The superiority of psychotherapy and antidepressant groups over treatment as usual was similar in those with and without psychiatric disorder. Multiple regression found significant independent effects of change in depression, anxiety, somatization and abdominal pain but there was still variance explained by treatment group.
  
  
  CONCLUSIONS
  In severe IBS improvement in health-related quality of life following psychotherapy or antidepressants is correlated with, but not explained fully by reduction of psychological scores. A more complete understanding of how these treatments help patients with medically unexplained symptoms will enable us to refine them further.
authors.affiliation: School of Psychiatry and Behavioural Science, University of Manchester, Rawnsley Building, Oxford Road, Manchester M13 9WL, UK. francis.creed@manchester.ac.uk
authors.forename: Francis
authors.initials: F
authors.lastname: Creed
authors.forename: Elspeth
authors.initials: E
authors.lastname: Guthrie
authors.forename: Joy
authors.initials: J
authors.lastname: Ratcliffe
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Fernandes
authors.forename: Christine
authors.initials: C
authors.lastname: Rigby
authors.forename: Barbara
authors.initials: B
authors.lastname: Tomenson
authors.forename: Nicholas
authors.initials: N
authors.lastname: Read
authors.forename: David G
authors.initials: DG
authors.lastname: Thompson
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D002648:Child; D002649:Child Abuse / Q000175:diagnosis / Q000523:psychology / Q000706:statistics & numerical data; D003131:Combined Modality Therapy; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care / Q000706:statistics & numerical data; D010147:Pain Measurement / Q000706:statistics & numerical data; D017374:Paroxetine / Q000627:therapeutic use; D010348:Patient Care Team; D010552:Personality Assessment / Q000706:statistics & numerical data; D010555:Personality Inventory / Q000706:statistics & numerical data; D011575:Psychoanalytic Therapy; D011594:Psychometrics / Q000706:statistics & numerical data; D011602:Psychophysiologic Disorders / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy*; D012017:Referral and Consultation; D015203:Reproducibility of Results; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D013001:Somatoform Disorders / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors