title: Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation.
abstract: The aim of the present study was to test the hypothesis that immobilization of bone morphogenic protein (BMP2) on the surface of titanium implants can enhance peri-implant bone formation. Ten adult female foxhounds received experimental titanium screw implants in the mandible 3 months after removal of all premolar teeth. Three types of implant surfaces were evaluated in each animal: (i) implants with machined titanium surface, (ii) implants coated with collagen I, (iii) implants coated with collagen I, chondroitin sulphate (CS) and BMP2. Peri-implant bone regeneration was assessed using histomorphometry after 1 and 3 months in five dogs each by measuring bone-implant contact (BIC) and the volume density of the newly formed peri-implant bone (BVD). After 1 month, there was no significant enhancement in BIC values but volume density of the newly formed peri-implant bone was significantly higher in the two groups of coated implants. No significant difference was found between collagen and BMP2 coating. After 3 months, BIC was significantly higher in both collagen and BMP2-coated implants compared with implants with machined surfaces. Peri-implant BVD was also significantly increased in coated implants in comparison with machined surfaces. It was concluded that collagen coating of dental screw implants can enhance BIC and peri-implant bone formation. Addition of BMP2 does not increase peri-implant bone formation in the present application.
authors.affiliation: Department of Oral and Maxillofacial Surgery, George-Augusta University, Göttingen, Germany. schliephake.henning@med.uni-goettingen.de
authors.forename: Henning
authors.initials: H
authors.lastname: Schliephake
authors.forename: Arash
authors.initials: A
authors.lastname: Aref
authors.forename: Dieter
authors.initials: D
authors.lastname: Scharnweber
authors.forename: Susanne
authors.initials: S
authors.lastname: Bierbaum
authors.forename: Sophie
authors.initials: S
authors.lastname: Roessler
authors.forename: Andreas
authors.initials: A
authors.lastname: Sewing
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003094:Collagen / Q000494:pharmacology; D015921:Dental Implants; D004285:Dogs; D005260:Female; D013499:Surface Properties; D014025:Titanium
chemical_list: D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003094:Collagen; D014025:Titanium