Diffusion tensor imaging in progressive multifocal leukoencephalopathy: early predictor for demyelination?
Progressive multifocal leukoencephalopathy is a severe demyelinating disease of the central nervous system caused by a JC papovavirus infection. Prognosis is poor with fatal outcome within 1 year in 90% of patients. Our case report shows that diffusion tensor imaging can give early and specific information about disease status and extent in a 15-year-old girl with progressive multifocal leukoencephalopathy associated with congenital human immunodeficiency virus (HIV) infection.
Huisman
Thierry A G M
TA
Department of Diagnostic Imaging ,University Children's Hospital Zurich, Zurich, Switzerland.
Boltshauser
Eugen
E
Martin
Ernst
E
Nadal
David
D
D000293:Adolescent; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000821:virology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000151:congenital; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000821:virology; D011237:Predictive Value of Tests; D013997:Time Factors