title: An integrated data-warehouse-concept for clinical and biological information.
abstract: The development of medical research networks within the framework of translational research has fostered interest in the integration of clinical and biological research data in a common database. The building of one single database integrating clinical data and biological research data requires a concept which enables scientists to retrieve information and to connect known facts to new findings. Clinical parameters are collected by a Patient Data Management System and viewed in a database which also includes genomic data. This database is designed as an Entity Attribute Value model, which implicates the development of a data warehouse concept. For the realization of this project, various requirements have to be taken into account which has to be fulfilled sufficiently in order to align with international standards. Data security and protection of data privacy are most important parts of the data warehouse concept. It has to be clear how patient pseudonymization has to be carried out in order to be within the scope of data security law. To be able to evaluate the data stored in a database consisting of clinical data collected by a Patient Data Management System and genomic research data easily, a data warehouse concept based on an Entity Attribute Value datamodel has been developed.
authors.affiliation: Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Giessen, Germany.
authors.forename: Dominik
authors.initials: D
authors.lastname: Brammen
authors.forename: Christian
authors.initials: C
authors.lastname: Katzer
authors.forename: Rainer
authors.initials: R
authors.lastname: Röhrig
authors.forename: Katja
authors.initials: K
authors.lastname: Weismüller
authors.forename: Michael
authors.initials: M
authors.lastname: Maier
authors.forename: Hamid
authors.initials: H
authors.lastname: Hossain
authors.forename: Thilo
authors.initials: T
authors.lastname: Menges
authors.forename: Gunter
authors.initials: G
authors.lastname: Hempelmann
authors.forename: Trinad
authors.initials: T
authors.lastname: Chakraborty
mesh_terms: D016494:Computer Security; D003628:Database Management Systems; D016208:Databases, Factual; D023281:Genomics; D006801:Humans; D016247:Information Storage and Retrieval; D018907:Privacy; D057170:Translational Research, Biomedical