Lithium attenuates stress-induced impairment of long-term potentiation induction.
Stress impairs the induction of long-term potentiation in the hippocampus as well as hippocampus-dependent memory. Lithium, a classical mood stabilizer, is known to have beneficial effects on stress-induced impairment of spatial memory. In the present study, we investigated lithium effects on the impairment of long-term potentiation induction after exposure to acute immobilization stress. As previously reported, immobilization stress impaired long-term potentiation induction in the CA1 region of rat hippocampal slices. Treating the slices with 0.6 or 1 mM lithium attenuated impaired long-term potentiation induction in stressed animals. Lithium was without effect on long-term potentiation induction in unstressed animals or baseline synaptic responses in unstressed or stressed animals. These results demonstrate a protective effect of lithium against stress-induced impairment of long-term potentiation induction.
Lim
Ki-Young
KY
Department of Psychiatry, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea.
Yang
Jae-Jin
JJ
Lee
Deok S
DS
Noh
Jai Sung
JS
Jung
Min W
MW
Chung
Young-Ki
YK
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000379:methods; D066298:In Vitro Techniques; D008094:Lithium / Q000627:therapeutic use*; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical / Q000379:methods; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology
D018696:Neuroprotective Agents; D008094:Lithium