Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.
Lahm
George P
GP
DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@usa.dupont.com
Selby
Thomas P
TP
Freudenberger
John H
JH
Stevenson
Thomas M
TM
Myers
Brian J
BJ
Seburyamo
Gilles
G
Smith
Ben K
BK
Flexner
Lindsey
L
Clark
Christopher E
CE
Cordova
Daniel
D
D000586:Amination; D000818:Animals; D002118:Calcium / Q000378:metabolism; D007313:Insecta / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*
D007306:Insecticides; D019837:Ryanodine Receptor Calcium Release Channel; D062367:ortho-Aminobenzoates; D002118:Calcium