title: Reactive angioendotheliomatosis in association with a well-differentiated angiosarcoma.
abstract: A 55-year-old white female with a complex medical history including mixed connective tissue disease and peripheral vascular disease developed a group of red-purple papules on her proximal medial thigh that was followed, five months later, by the development of a large violaceous patch. She reported a history of radiation to this site (for melanoma) during her childhood. She was admitted to the hospital with a presumptive diagnosis of cellulitis, but failed to respond to antibiotics. A biopsy was performed and demonstrated a well-differentiated angiosarcoma arising in conjunction with reactive angioendotheliomatosis. Excision of the lesion was performed, and fifteen months of follow-up have shown no recurrence or metastasis.
authors.affiliation: Department of Pathology, The Penn State College of Medicine/Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA. lorenclarke@comcast.net
authors.forename: Loren E
authors.initials: LE
authors.lastname: Clarke
authors.forename: Kathleen G
authors.initials: KG
authors.lastname: Julian
authors.forename: Jennie T
authors.initials: JT
authors.lastname: Clarke
authors.forename: Michael D
authors.initials: MD
authors.lastname: Ioffreda
mesh_terms: D002481:Cellulitis / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006391:Hemangioma / Q000209:etiology / Q000473:pathology*; D006394:Hemangiosarcoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology*; D016491:Peripheral Vascular Diseases / Q000150:complications; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*