Fertility-sparing options for patients with gynecologic malignancies.
Gynecologic malignancies are most often diagnosed in postmenopausal women, but these malignancies also arise in premenopausal women, in whom issues of fertility can be a major concern. An increasing number of women are delaying childbearing. This has led to a significant increase in the number of women diagnosed with a gynecologic malignancy before desired completion of childbearing. Many of the standard treatments for these malignancies result in permanent sterility; however, there are now options for select young women who desire to preserve fertility. Patients should be told that data on fertility-sparing procedures are limited and that many of these options are of an experimental, nonstandard nature. The care of these patients is challenging and complex and requires a multidisciplinary approach, which should include gynecologic oncologists, reproductive endocrinologists, and perinatologists.
Leitao
Mario M
MM
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Women's Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, USA.
Chi
Dennis S
DS
D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000601:surgery; D005260:Female; D005298:Fertility; D005833:Genital Neoplasms, Female / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000601:surgery