[Expression and clinical significance of CD1a+ dendritic cells in glottic squamous cell carcinoma].
OBJECTIVE
Dendritic cells (DCs) are the most important antigen-presenting cells. CD1a, a marker of immature DCs, plays a role in tumorigenesis. This study was designed to explore the correlation of CD1a(+) DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma.


METHODS
Clinical and follow-up data of 111 patients with glottic squamous cell carcinoma were analyzed retrospectively. The expression of CD1a(+) DCs in the 111 specimens of glottic squamous cell carcinoma and 17 specimens of non-tumor tissue was detected by immunohistochemistry. Correlations of CD1a(+) DCs to pathologic degree, T stage, local recurrence, and prognosis of glottic squamous cell carcinoma were analyzed.


RESULTS
Positive rates of CD1a(+) DCs were 59.46% in glottic squamous cell carcinoma tissues, and 0 in non-tumor tissues; it was significantly higher in well-differentiated group than in moderately-and poorly-differentiated group [71.43% (55/77) vs. 28.57% (11/34), P<0.05], higher in T1-T2 group than in T3-T4 group [67.16% (45/67) vs. 47.73% (21/44), P<0.05], and higher in non-recurrence group than in local recurrence group [65.06% (54/83) vs. 42.86% (12/28), P<0.05].


CONCLUSIONS
The lower pathologic degree and higher T stage of glottic squamous cell carcinoma, the lower expression of CD1a(+) DCs. The positive rate of CD1a(+) DCs is low in recurrent glottic tumor. High expression of CD1a(+) DCs may indicate better prognosis of glottic squamous cell carcinoma.
Chen
Wen-Kuan
WK
State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P.R. China. chenwenkuan@163.com
Chen
Fu-Jin
FJ
Zeng
Zong-Yuan
ZY
Wu
Guo-Hao
GH
Guo
Zhu-Ming
ZM
Wei
Mao-Wen
MW
Yang
An-Kui
AK
Zhang
Quan
Q
He
Jie-Hua
JH
Hou
Jing-Hui
JH
D000328:Adult; D000368:Aged; D018949:Antigens, CD1 / Q000378:metabolism*; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis
D018949:Antigens, CD1; D014408:Biomarkers, Tumor; C419393:CD1a antigen