The interaction of antiarrhythmics with an anionic receptor site.
The applications of the methods of computational chemistry to the study of various physiochemical properties (molecular conformation, molecular electrostatic potentials, basicity, reactivity, lipophilicity) of antiarrhythmics are reviewed. The focus is on the application of ab initio SCF quantum mechanical methods to antiarrhythmic-receptor interactions and proton transfer, including the effect of small cations and water.
Remko
M
M
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 832 32 Bratislava, Slovak Republic. remko@fpharm.uniba.sk