Application of triazine "superactive esters" in the repetitive synthesis of oligopeptides. Part 2. Synthesis of N-terminal hexapeptide of emerimicin III.
N-terminal fragment of emerimicin III has been synthesized by the repetitive method in solution, involving triazine ,,superactive esters". The synthetic protocol, equivalent to the classic REMA procedure, has been applied in the step by step approach, and in the fragment coupling affording all the peptide bonds. By monitoring the progress of the synthesis by FAB-MS, 1H-NMR and HPLC, the structure and high purity of the final products have been confirmed.
Kamiński
Zbigniew J
ZJ
Institute of Organic Chemistry, Technical University of Lódź, 116 Zeromskiego Str., 90-924 Lódź, Poland.
Saleh
Bashar
B
Kolesińiska
Beata
B
Redliński
Adam
A
Rudziński
Juliusz
J
D002851:Chromatography, High Pressure Liquid; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis*; D054848:Peptaibols; D010455:Peptides / Q000032:analysis / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
D004952:Esters; D009842:Oligopeptides; D054848:Peptaibols; D010455:Peptides; D014227:Triazines