Antifungal susceptibility and pathogenic potential of environmental isolated filamentous fungi compared with colonizing agents in immunocompromised patients.
Infection is a major cause of morbidity and mortality in bone marrow transplant recipients and in patients with hematological malignancies. The source of infection is almost always endogenous flora or the hospital environment. The present study evaluated bone marrow transplant recipients and patients with hematological malignancies colonized and/or infected with filamentous fungi. During 1 year, environmental air samples were also taken from the bone marrow transplant unit by a modification of gravity air-setting plate (GASP) methodology. Fusarium spp. were the most prevalent genus in the fall and Cladosporium spp. in the winter. Clinically isolated strains grew better at 37 degrees C than environmental strains. According to NCCLS M-38P methods, environmental Aspergillus strains showed higher MICs to miconazol and itraconazol, and clinical Fusarium strains were less susceptible to fluconazole.
Teixeira
A B A
AB
Clinical Pathology Department, School of Medical Sciences, State University of Campinas, São Paulo, Brazil.
Silva
M
M
Lyra
L
L
Luz
E A
EA
Uno
J
J
Takada
H
H
Miyaji
M
M
Nishimura
K
K
Schreiber
A Z
AZ
D000391:Air Microbiology; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002963:Cladosporium / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D019337:Hematologic Neoplasms / Q000150:complications; D006784:Hospitals, Teaching; D006801:Humans; D016867:Immunocompromised Host; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity*; D009181:Mycoses / Q000382:microbiology*
D000935:Antifungal Agents