Selective deacetylation of zaluzanin D using transformed Escherichia coli cultures.
The use of conventional and unconventional reaction methodology for the hydrolysis of the acetate group in zaluzanin D resulted in hydration of the 11,13 exocyclic bond along with deacetylation. But the microorganism E. coli selectively cleaved the acetate group to yield zaluzanin C.
Ganesh
Munuswamy Ramanujam
MR
Department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India.
Arunachalam
Jothi
J
Krithika
Anand
A
Rajan
Sundarajan Sundar
SS
D000935:Antifungal Agents / Q000494:pharmacology; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D045789:Sesquiterpenes, Guaiane
D000935:Antifungal Agents; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C000621518:zaluzanin C; C474047:zaluzanin-D