Ushikulides A and B, immunosuppressants produced by a strain of Streptomyces sp.
Novel immunosuppressants, ushikulides A and B, were isolated from the culture broth of Streptomyces sp. IUK-102. Ushikulides A and B both have the same molecular formula, determined as C40H68O10. The structures of both compounds were elucidated to be novel 22-membered macrolides. Both compounds showed immunosuppressive activity for murine splenocyte proliferation in vitro.
Takahashi
Kosaku
K
Graduate School of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan. kosaku@chem.agr.hokudai.ac.jp
Yoshihara
Teruhiko
T
Kurosawa
Kazuhiko
K
D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D007624:KB Cells; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D018942:Macrolides / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
D007166:Immunosuppressive Agents; D018942:Macrolides; C504254:ushikulide A; C504255:ushikulide B