title: IL-6 and FAS (CD95) serum level in patients suffering from psoriasis and in relation to the lymphocyte subpopulations.
abstract: In the presented study the subpopulations of blood lymphocytes as well as serum concentrations of IL-6 and FAS in 20 patients with psoriasis triggered by infection and 17 healthy controls were analyzed. The flow cytometry technique and ELISA method were used. We detected statistically significant higher serum level of interleukin-6 (IL-6) in patients with active disease and tendency to the lowering of FAS level, although not statistically significant. Analysis of the correlation between the parameters showed that it was close to statistical significance for IL-6 and CD 95, p = 0.06 and R = 0.41. IL-6 level correlated positively with percentage of CD45RO+ cells (p = 0.05, R = 0.28) and negatively with percentage of CD3+ cells (p = 0.02, R = -0.34), CD4+ cells (p = 0.02, R = -0.34), CD 45RA+ cells (p = 0.04, R = -0.68).
authors.affiliation: Chair and Department of Dermatology, Skubiszewski Medical University of Lublin.
authors.forename: Aldona
authors.initials: A
authors.lastname: Pietrzak
authors.forename: Monika
authors.initials: M
authors.lastname: Podhorecka
authors.forename: Grazyna
authors.initials: G
authors.lastname: Chodorowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Roliński
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kowal
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Junak-Bojarska
authors.forename: Janusz
authors.initials: J
authors.lastname: Urban
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000276:immunology; D049109:Cell Proliferation; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D015603:Keratinocytes / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000150:complications / Q000276:immunology; D013223:Statistics as Topic; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019014:fas Receptor / Q000097:blood*
chemical_list: D015850:Interleukin-6; D019014:fas Receptor