Hypothesis: could Meniere's disease be a channelopathy?
Meniere's disease is a clinical syndrome of uncertain aetiology but it is a widespread belief that it is related to endolymphatic hydrops. Clinically, it is a paroxysmal disorder with vertigo and subsequent deafness. It is responsive to acetazolamide and sensitive to the sodium content in the diet, many of the features of the channelopathies. The present paper explores the possibility that it may be related to a channelopathy.
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Neuroscience Department, Geelong Hospital, Barwon Health, Geelong, Victoria, Australia. peterga@barwonhealth.org.au
D000086:Acetazolamide / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D018450:Disease Progression; D018159:Endolymphatic Hydrops / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006199:Hair Cells, Auditory, Inner / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D018570:Risk Assessment; D012720:Severity of Illness Index; D014717:Vertigo / Q000209:etiology* / Q000503:physiopathology
D000086:Acetazolamide