title: The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. I. Taxonomy, fermentation, isolation and physico-chemical properties.
abstract: FR225654, a novel gluconeogenesis inhibitor, was isolated from the culture broth of Phoma sp. No. 00144 and purified by adsorptive resin and reverse-phase column chromatography. This compound is a potent inhibitor of gluconeogenesis and is a promising candidate of anti-diabetic agent.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd. yoshihiro.ohtsu@jp.astellas.com
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohtsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sasamura
authors.forename: Miho
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: Seiji
authors.initials: S
authors.lastname: Yoshimura
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005285:Fermentation; D005658:Fungi; D005943:Gluconeogenesis / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
chemical_list: C504133:FR225654; D007004:Hypoglycemic Agents; D009281:Naphthalenes