Signal transduction: how rad53 kinase is activated.
Recent studies have elucidated the activation mechanism of the Rad53 checkpoint kinase and the role of Rad9-like adaptor proteins in mediating signal transduction from PIKK sensor kinases that detect DNA damage to the effector kinases that play a part in mending that damage.
Pellicioli
Achille
A
FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milano, Italy.
Foiani
Marco
M
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D064447:Checkpoint Kinase 2; D004249:DNA Damage; D004789:Enzyme Activation / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008954:Models, Biological; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D015003:Yeasts
D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; D064447:Checkpoint Kinase 2; C088937:MEC1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases