Amiodarone and optic neuropathy: the heart of the matter.
Amiodarone is one of the most effective antiarrhythmic drugs currently available. Although a subject of intense controversy, a causal link between amiodarone and optic neuropathy has never been firmly established. Indications for treatment with amiodarone are outlined, and features of the optic neuropathy in patients on amiodarone are compared with those of nonarteritic anterior ischemic optic neuropathy. An approach to patients treated with amiodarone who present with optic neuropathy is outlined, and suggestions for a registry and prospective study of such patients are presented.
Murphy
Marjorie A
MA
Department of Ophthalmology, Rhode Island Hospital, Brown Medical School, Providence, RI 02903, USA. margiemurphy@cox.net
Murphy
John F
JF
D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012042:Registries
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone