[Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle].
Meningeal melanocytoma refers to the uncommon clinical appearance of a generally benign tumour deriving from leptomeningeal melanocytes. Meningeal spread of this tumour is very rarely observed. We present the case of a 38-year-old man with meningeal melanocytoma of the cerebello-pontine angle, who showed a biphasic course of this disease, with a stable period followed by a steady progress within few months. After surgical resection of the melancytoma in the left skull base and of a first local recurrence five years later, a second local recurrence occurred 6 years after diagnosis, with intracerebral and spinal meningeal seeding. This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse. Secondary malignisation of the melancytoma is suggested.
Koch
Horst J
HJ
Neurologische Universitätsklinik Regensburg, Deutschland. horst.koch@medbo.de
Roeber
Sigrun
S
Zimmermann
Udo W
UW
Schäfer
Christof
C
Villarrubia
Victoria
V
Kuchelmeister
Klaus
K
Schachenmayr
Walter
W
Bogdahn
Ulrich
U
Steinbrecher
Andreas
A
D000284:Administration, Oral; D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use; D001099:Arachnoid; D002526:Cerebellar Diseases / Q000175:diagnosis; D002528:Cerebellar Neoplasms / Q000175:diagnosis; D002530:Cerebellopontine Angle; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008578:Meninges; D009364:Neoplasm Recurrence, Local; D009366:Neoplasm Seeding; D010841:Pia Mater; D011879:Radiotherapy Dosage; D000077204:Temozolomide; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide