title: No protective effect of breastfeeding on inhibitor formation in severe hemophilia.
abstract: It has been suggested that breastfeeding may prevent inhibitor formation in patients with hemophilia. In a single-center retrospective cohort study, the authors studied the association between breastfeeding and inhibitor development in 90 severe hemophilia A patients born 1975-2003. Mean follow-up was 13.2 years (standard deviation 8.7). A total of 62% of patients received breastfeeding and 20% developed inhibitors. The inhibitor rate according to breastfeeding was similar: 21% in patients who were breastfed and 18% in others. Patients who were breastfed received their first treatment 0.3 years earlier. After adjustment for age at first treatment, we found no protective effect of breastfeeding on inhibitor formation.
authors.affiliation: Van Creveldkliniek, Dutch National Haemophilia Treatment Centre, UMC Utrecht, The Netherlands.
authors.forename: Ilse M J
authors.initials: IM
authors.lastname: Jansen
authors.forename: Kathelijn
authors.initials: K
authors.lastname: Fischer
authors.forename: Johanna G
authors.initials: JG
authors.lastname: Van Der Bom
authors.forename: H Marijke
authors.initials: HM
authors.lastname: Van Den Berg
mesh_terms: D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D001942:Breast Feeding; D015331:Cohort Studies; D005260:Female; D006467:Hemophilia A / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D019774:Blood Coagulation Factor Inhibitors