Age-related morphology trends of cortical sulci.
The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).
Kochunov
Peter
P
Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Mangin
Jean-François
JF
Coyle
Thomas
T
Lancaster
Jack
J
Thompson
Paul
P
Rivière
Dennis
D
Cointepas
Yann
Y
Régis
Jean
J
Schlosser
Anita
A
Royall
Don R
DR
Zilles
Karl
K
Mazziotta
John
J
Toga
Arthur
A
Fox
Peter T
PT
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001284:Atrophy / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology