DNase II is a member of the phospholipase D superfamily.
BACKGROUND
DNase II is an endodeoxyribonuclease involved in apoptosis and essential for the mammalian development. Despite the understanding of biochemical properties of this enzyme, its structure and relationships to other protein families remain unknown.


RESULTS
Using protein fold-recognition we found that DNase II exhibits a catalytic domain common to the phospholipase D superfamily. Our model explains the available experimental data and provides the first structural platform for sequence-function analyses of this important nuclease.
Cymerman
Iwona A
IA
Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland. iamb@genesilico.pl
Meiss
Gregor
G
Bujnicki
Janusz M
JM
D000595:Amino Acid Sequence; D003198:Computer Simulation; D004706:Endodeoxyribonucleases / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010739:Phospholipase D / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D011487:Protein Conformation; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
D004706:Endodeoxyribonucleases; C019329:deoxyribonuclease II; D010739:Phospholipase D