title: Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein.
abstract: An artificial phospholipid, possessing saturated alkyl chains as a membrane anchor and protein recognition site as well as an Fe(III)-EDTA moiety as a protein cleavable polar head group, was designed and synthesized based on the amidite method for the purpose of examination of cleavage of integral membrane proteins.
authors.affiliation: Department of Synthetic Organic and Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Furuta
authors.forename: Minatsu
authors.initials: M
authors.lastname: Sakai
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Hayashi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Asakawa
authors.forename: Fumi
authors.initials: F
authors.lastname: Kataoka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Nathan
authors.initials: N
authors.lastname: Fishkin
authors.forename: Koji
authors.initials: K
authors.lastname: Nakanishi
mesh_terms: D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D006388:Hemagglutinins; D007202:Indicators and Reagents; D007502:Iron Chelating Agents / Q000737:chemistry; D008051:Lipid Bilayers; D008279:Magnetic Resonance Imaging; D008565:Membrane Proteins / Q000737:chemistry*; D010743:Phospholipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D000509:alpha-Fetoproteins / Q000737:chemistry
chemical_list: D006388:Hemagglutinins; D007202:Indicators and Reagents; D007502:Iron Chelating Agents; D008051:Lipid Bilayers; D008565:Membrane Proteins; D010743:Phospholipids; D000509:alpha-Fetoproteins