Molecular pathways leading to cancer cachexia.
Loss of body weight in cancer patients strongly influences morbidity and mortality. Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.
Tisdale
Michael J
MJ
Cancer Biochemistry, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom. m.j.tisdale@aston.ac.uk
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002100:Cachexia / Q000209:etiology* / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D009369:Neoplasms / Q000150:complications* / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism; D011509:Proteoglycans
D001798:Blood Proteins; D016207:Cytokines; D010455:Peptides; D011509:Proteoglycans; C008287:lipid mobilizing substance; C042057:proteolysis-inducing peptide