title: The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides.
abstract: The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate functional activity.
authors.affiliation: Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.forename: Michael T
authors.initials: MT
authors.lastname: Migawa
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Sannes-Lowery
authors.forename: Eric E
authors.initials: EE
authors.lastname: Swayze
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D014176:Protein Biosynthesis / Q000187:drug effects; D012336:RNA, Ribosomal, 16S / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D012336:RNA, Ribosomal, 16S