Different effects of adenosine A1 agonist ribavirin on amphetamine-induced total locomotor and stereotypic activities in rats.
Pretreatment with a single dose of ribavirin (10, 20, and 30 mg/kg b.w., i.p.) decreased amphetamine (1.5 mg/kg b.w., i.p.)-induced total locomotor activity (distance traveled) compared to amphetamine alone, but the most significant effect was observed with 30 mg/kg dose. In contrast, total stereotypic activities (such as sniffing, self-grooming, licking, and head weaving) of these animals were unchanged. These findings demonstrate the ability of ribavirin to modulate in a different way central regulation of locomotor and stereotypic activities that in the future could have a practical application in target therapy of some movement disorders.
Janać
Branka
B
Institute for Biological Research Sinisa Stanković, Belgrade, Serbia and Montenegro. janac@ibiss.bg.ac.yu
Pesić
Vesna
V
Peković
Sanja
S
Rakić
Ljubisav
L
Stojiljković
Mirjana
M
D058907:Adenosine A1 Receptor Agonists; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007267:Injections; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012254:Ribavirin / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D058907:Adenosine A1 Receptor Agonists; D000998:Antiviral Agents; D012254:Ribavirin; D000661:Amphetamine