Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.
Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors). In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. Nimesulide was administered orally, twice a day at the conventional dose of 0.1 g for five days. In the next (or previous) 5 days the same patients were administered with ketoprofen at the dose of 0.05 g three times a day. On the last day of the NSAID administration period, 24-hour blood pressure monitoring was performed. Our results indicate no difference between nimesulide and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
Saran
Tomasz
T
Rehabilitation Ward, Department of Internal and Occupational Medicine, Institute of Agricultural Medicine, Lublin.
Sodolski
Wojciech
W
Sodolska
Katarzyna
K
Danilkiewicz
Wit Cezary
WC
Schabowski
Janusz
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002940:Circadian Rhythm; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007660:Ketoprofen / Q000494:pharmacology*; D008875:Middle Aged; D013449:Sulfonamides / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; D007660:Ketoprofen; C012655:nimesulide