title: Fetal response to maternal exercise in pregnancies with uteroplacental insufficiency.
abstract: OBJECTIVE
  The purpose of this study was to determine the fetal response to submaximal maternal exercise at 22 to 26 weeks in pregnancies with abnormal uterine artery Doppler.
  
  
  METHODS
  This was a prospective comparison of singleton pregnancies with uteroplacental vascular insufficiency (UPVI) (mean uterine pulsatility index [PI] values >1.45 [n = 12]) and those with normal uterine artery Doppler (n = 23). Maternal and fetal cardiovascular responses to 5 minutes of steady state cycling at 10% and at 15% of predicted work rate maximum were studied.
  
  
  RESULTS
  Umbilical artery Doppler deteriorated after exercise in patients with UPVI (pre PI 1.4 [0.35-2.14], post PI 1.64 [0.45-2.18]). Three (25%) had transient absent-end diastolic flow (AEDF) in umbilical artery, 2 of which developed early-onset intrauterine growth restriction (IUGR) with AEDF. Fetal cardiac output studies remained stable during the examinations.
  
  
  CONCLUSIONS
  Submaximal steady state exercise had a transient deleterious effect in a subset of women with uteroplacental vascular insufficiency destined to develop early-onset IUGR.
authors.affiliation: Division of Maternal-Fetal Medicine, Mount Sinai Hospital, Canada.
authors.forename: Vandana
authors.initials: V
authors.lastname: Chaddha
authors.forename: Michal J
authors.initials: MJ
authors.lastname: Simchen
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Hornberger
authors.forename: Victoria M
authors.initials: VM
authors.lastname: Allen
authors.forename: Shafagh
authors.initials: S
authors.lastname: Fallah
authors.forename: Allan L
authors.initials: AL
authors.lastname: Coates
authors.forename: Anita
authors.initials: A
authors.lastname: Roberts
authors.forename: Donna L
authors.initials: DL
authors.lastname: Wilkes
authors.forename: Jane
authors.initials: J
authors.lastname: Schneiderman-Walker
authors.forename: Edgar
authors.initials: E
authors.lastname: Jaeggi
authors.forename: John C P
authors.initials: JC
authors.lastname: Kingdom
mesh_terms: D000328:Adult; D015150:Echocardiography, Doppler; D015444:Exercise / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000502:physiology*; D006340:Heart Rate, Fetal / Q000502:physiology; D006801:Humans; D010927:Placental Insufficiency / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology; D014469:Umbilical Arteries / Q000503:physiopathology*