Association of MHC class I chain related gene-A microsatellite polymorphism with the susceptibility to T1DM and LADA in Czech adult patients.
The results in this study suggest that microsatellite polymorphism within the transmembrane region of MIC-A gene is associated with genetic susceptibility to adult-onset of type 1 diabetes mellitus (T1DM), MIC-A5.1 allele, corrected P = 0.001, whereas it is not associated with latent autoimmune diabetes in adults (LADA) in Czech population. According to our findings, we can hypothesize that adult-onset T1DM and LADA may have partly different immunogenetic aetiopathogenesis.
Novota
P
P
Department of Cell and Molecular Biology, the 3rd Faculty of Medicine, Charles University, Ruská 87, 100 21 Prague 10, Czech Republic.
Kolostova
K
K
Pinterova
D
D
Novak
J
J
Weber
P
P
Treslova
L
L
Kovar
J
J
Andel
M
M
Cerna
M
M
D000328:Adult; D018153:Czech Republic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A