A strategy for integrative computational physiology.
Organ function (the heart beat for example) can only be understood through knowledge of molecular and cellular processes within the constraints of structure-function relations at the tissue level. A quantitative modeling framework that can deal with these multiscale issues is described here under the banner of the International Union of Physiological Sciences Physiome Project.
Hunter
Peter
P
Bioengineering Institute, University of Auckland, Auckland, New Zealand. p.hunter@auckland.ac.nz
Nielsen
Poul
P
D002468:Cell Physiological Phenomena; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D006801:Humans; D008954:Models, Biological; D008955:Models, Cardiovascular; D010827:Physiology / Q000379:methods*; D014584:User-Computer Interface