[Clinical analysis of prognostic factors for patients with gastrointestinal stromal tumors].
OBJECTIVE
To investigate the prognostic factors for patients with gastrointestinal stromal tumors (GIST).


METHODS
From 2000 to 2003, clinical data of 41 cases with GIST were reviewed retrospectively. The clinicopathologic diagnosis was determined by immunochemistry. The relationships of the prognosis with mitotic counts, tumor size and location,range of tumor resection were analyzed.


RESULTS
The patients with GIST had pathological section of high expression in CD117, CD34 and vimentin (92.7%, 82.9%, 78%, respectively). Patients with tumor location in intestine, tumor size > 5 cm,mitotic counts > 5/50HPF, incomplete resection had poorer outcome, compared with those with tumor location in stomach and colon,tumor size < or = 5 cm,mitotic counts < or = 5/50HPF and complete resection (all P< 0.05).


CONCLUSIONS
Complete gross resection can improve prognosis for patients with GIST. Tumors with mitotic counts > or = 5/50HPF, tumor size more than 5 cm and tumor location in intestine are poor prognostic factors.
Jie
Zhi-gang
ZG
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006, China. jiezg@jiangxi.gov.cn
Xie
Xiao-ping
XP
Qin
Ke-wang
KW
Liu
Yi
Y
Li
Zheng-rong
ZR
Dai
An-bang
AB
Yao
Yu-xiu
YX
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult