title: Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier.
authors.affiliation: Institute of Clinical Pharmacology, Otto-von-Guericke-University, Leipziger Strasse 44, D-39120 Magdeburg, Germany. uwe.troeger@medizin.uni-magdeburg.de
authors.forename: Uwe
authors.initials: U
authors.lastname: Tröger
authors.forename: Hartmut
authors.initials: H
authors.lastname: Lins
authors.forename: Jean-M
authors.initials: JM
authors.lastname: Scherrmann
authors.forename: Claus-Werner
authors.initials: CW
authors.lastname: Wallesch
authors.forename: Stefanie M
authors.initials: SM
authors.lastname: Bode-Böger
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000187:drug effects*; D003078:Colchicine / Q000009:adverse effects* / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D011782:Quadriplegia / Q000139:chemically induced*; D014700:Verapamil / Q000009:adverse effects*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014700:Verapamil; D003078:Colchicine