title: Asynchronous regional brain volume losses in presymptomatic to moderate AD.
abstract: To determine if rates and locations of brain volume loss associated with AD are phase-specific, occurring prior to clinical onset and at later stages, we performed longitudinal volumetric MRI analysis on 155 subjects enrolled in a prospective study of aging and dementia. Subjects were divided by Clinical Dementia Rating (CDR) scale into stages of Normal (CDR 0 --> 0), Very Mild (CDR 0 --> 0.5 and 0.5 --> 0.5), Mild (CDR 0.5 --> 1.0 and 1.0 --> 1.0) and Moderate (CDR 1.0 --> 2.0 and 2.0 --> 2.0) dementia. Rates of volume change in CSF spaces, lobar and medial temporal lobe regions were analyzed for group differences across stages. Annual rates of ventricular volume change differed between non-demented and very mild group (p<0.01). In later severity stages, ventricular, temporal, basal ganglia-thalamic region and total volumes show change. Rates of volume loss increase as dementia progresses, but not uniformly in all regions. These regional and phase-specific volume changes form targets for monitoring disease-modifying therapies at clinically relevant, defined stages of dementia.
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA. kaye@ohsu.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Kaye
authors.forename: M M
authors.initials: MM
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Dame
authors.forename: J
authors.initials: J
authors.lastname: Quinn
authors.forename: R
authors.initials: R
authors.lastname: Camicioli
authors.forename: D
authors.initials: D
authors.lastname: Howieson
authors.forename: E
authors.initials: E
authors.lastname: Corbridge
authors.forename: B
authors.initials: B
authors.lastname: Care
authors.forename: G
authors.initials: G
authors.lastname: Nesbit
authors.forename: G
authors.initials: G
authors.lastname: Sexton
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D001284:Atrophy; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000502:physiology; D018450:Disease Progression; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule