[Study of dopamine effect on neuroendocrine disorders during polycystic-ovary syndrome using the method of enzyme-linked immunosorbent analysis (ELISA)].
The goal of this work was to study the influence of chronic stress on the development of neuroendocrine disorders and to establish the role of hypothalamo-dopaminergic system in the formation of polycystic-ovary syndrome (POS) of central form. Our data indicate that an increase of luteinizing hormone (LH) in the blood of patients diagnosed with POS of central genesis is conditioned both by the decrease of the influence of dopaminergic system and increased secretory activity of LH releasing generating neutrons causing chronic stress. Thus the fact that well-pronounced decrease of dopamine level is observed in persons forcedly displaced evidences that chronic stress is an important risk factor of the development of POS of central genesis. Chronic stress leads to the disorder of the central mechanisms of neuroregulation of hypothalamo-hypophysial system and aggravation of the disorders of females' reproductive function.
Gogokhiia
N A
NA
Natmeladze
K M
KM
Mikaberidze
Kh L
KhL
D000328:Adult; D004298:Dopamine / Q000172:deficiency* / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology*
D004298:Dopamine