title: Comparison of plasma endothelin levels between osteoporotic, osteopenic and normal subjects.
abstract: BACKGROUND
  It has been demonstrated that endothelins (ET) have significant roles in bone remodeling, metabolism and physiopathology of several bone diseases. We aimed to investigate if there was any difference between the plasma ET levels of osteoporotic patients and normals.
  
  
  METHODS
  86 patients (70 women and 16 men) with a mean age of 62.6 (ranges: 51-90) years were included in this study. Patients were divided into groups of osteoporosis, osteopenia and normal regarding reported T scores of DEXA evaluation according to the suggestions of World Health Organization. According to these criteria 19, 43 and 24 were normal, osteopenic and osteoporotic respectively. Then total plasma level of ET was measured in all patients with monoclonal antibody based sandwich immunoassay (EIA) method. One-way analysis of variance test was used to compare endothelin values between normals, osteopenics and osteoporotics.
  
  
  RESULTS
  Endothelin total plasma level in patients was a mean of 98.36 +/- 63.96, 100.92 +/- 47.2 and 99.56 +/- 56.6 pg/ml in osteoporotic, osteopenic and normal groups respectively. The difference between groups was not significant (p > 0.05).
  
  
  CONCLUSIONS
  No significant differences in plasma ET levels among three groups of study participants could be detected in this study.
authors.affiliation: 3rd Orthopaedics and Traumatology Clinic, Ankara Numune Education and Research Hospital, Talatpaşa Bulvari, Sihhiye, Ankara, Turkey. hasanmuratli@yahoo.com
authors.forename: Hasan Hilmi
authors.initials: HH
authors.lastname: Muratli
authors.forename: Levent
authors.initials: L
authors.lastname: Celebi
authors.forename: Onur
authors.initials: O
authors.lastname: Hapa
authors.forename: Ali
authors.initials: A
authors.lastname: Biçimoğlu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D000886:Anthropometry; D001851:Bone Diseases, Metabolic / Q000097:blood*; D016022:Case-Control Studies; D016232:Endothelins / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood*; D012727:Sex Characteristics
chemical_list: D016232:Endothelins