Urinary 8-hydroxy-2'-deoxyguanosine and serum S100beta in acute cardioembolic stroke patients.
OBJECTIVE
Our aim was to explore whether free radical damage against DNA exists or not, in human stroke patients.


METHODS
Urinary 8-hyroxy-2'-deoxyguanosine (8-OHdG) and serum S100beta were measured in acute cardioembolic stroke patients with relatively severe symptoms. During days 3--5 after the onset of stroke, urine was collected for 24 hours for 8-OHdG measurement and serum was sampled for S100beta analysis every day.


RESULTS
The total urinary 8-OHdG content was significantly higher in stroke patients than in non-stroke inpatients (p<0.01). The average value was more than twice the value of that of non-stroke inpatients. The total urinary 8-OHdG contents showed significant correlation (r=0.87, p<0.01) with serum S100beta values, which are reportedly related to brain damage.


CONCLUSIONS
These findings suggest that urinary 8-OHdG in acute stroke patients may originate from brain tissue, and DNA damage also exists in the brain of stroke patients.
Mizukoshi
Genki
G
The Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Katsura
Ken-Ichiro
K
Katayama
Yasuo
Y
D000368:Aged; D002341:Carotid Artery Thrombosis / Q000150:complications / Q000473:pathology; D003839:Deoxyadenosines / Q000652:urine*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013223:Statistics as Topic; D020521:Stroke / Q000097:blood* / Q000473:pathology / Q000652:urine*
C436623:8-hydroxy-2'-deoxyadenosine; D003839:Deoxyadenosines; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins