Estrogen receptor dinucleotide repeat polymorphism is associated with minimal or mild endometriosis.
The present study was designed to explore the association between estrogen receptor-alpha gene polymorphism and the risk of endometriosis by investigating the frequency of PvuII, XbaI, and thymine-adenine (TA) repeat polymorphisms in patients with and without endometriosis in a Korean population. Although there was no significant difference in the allele distribution and frequency of either PvuII or XbaI polymorphisms between endometriosis patients and control subjects, patients with stage I/II endometriosis showed a higher incidence of alleles with fewer (TA)n repeats (12-15 repeats) compared with controls.
Kim
Sung Hoon
SH
Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, South Korea.
Choi
Young Min
YM
Jun
Jong Kwan
JK
Kim
Seok Hyun
SH
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D018900:Dinucleotide Repeats / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics* / Q000503:physiopathology; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D007723:Korea; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic
D047628:Estrogen Receptor alpha