High incidence of cytomegalovirus reactivation in adult recipients of an unrelated cord blood transplant.
This retrospective analysis of cytomegalovirus (CMV)-seropositive adult transplant recipients showed that CMV antigenemia occurred after transplantation in 10/10 (100%) recipients of unrelated cord blood, 17/39 (43%) recipients of a related matched donor graft, 16/23 (79%) recipients of an unrelated matched donor graft, and 8/12 (67%) recipients of a mismatched related donor graft. These results suggest that unrelated cord blood transplantation itself may be correlated with a high incidence of CMV reactivation.
Takami
Akiyoshi
A
Mochizuki
Kanako
K
Asakura
Hidesaku
H
Yamazaki
Hirohito
H
Okumura
Hirokazu
H
Nakao
Shinji
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000601:surgery* / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014775:Virus Activation