title: Effects of reperfusion obtained two to six months after acute myocardial infarction on myocardial electrical stabilization in patients with an occluded infarct-related coronary artery.
abstract: To assess the changes in electrical stability markers in patients with previous myocardial infarction after very late reopening of the infarct-related artery, we studied QT dispersion, corrected-QT dispersion, and late potentials before and 1, 3, and 6 months after an attempt at late percutaneous coronary intervention (PCI) in 31 consecutive patients with single-vessel disease (infarct-related artery occlusion or subocclusion) diagnosed > or = 4 weeks after the ST-elevation myocardial infarction. Patients underwent PCI 3.9 +/- 2 months after ST-elevation myocardial infarction. PCI was successful in 24 patients (group A) and unsuccessful in 7 (group B). The 2 groups were similar in clinical and angiographic characteristics, as well as the prevalence of basal late potentials, average QT dispersion, and corrected-QT dispersion. One month after PCI, the successful reperfusion group had a significant 67% decrease in the prevalence of late potentials and average QT dispersion and corrected QT dispersion (51 +/- 9 vs 72 +/- 11 ms, p <0.00001, and 51 +/- 10 vs 76 +/- 15 ms, p <0.00001, respectively). These benefits remained stable at 3 and 6 months after PCI. Conversely, the unsuccessful group did not show any improvement in electrical stability markers after PCI failed. Thus, reperfusion obtained very late after ST-elevation myocardial infarction confers significant electrical stabilization that may contribute to a better outcome in patients with patent infarct-related arteries.
authors.affiliation: Ricerche Orientate sulla Malattia Aterosclerotica Core Laboratory and Coronary Intervention Unit, San Filippo Neri Hospital, Rome, Italy. c.pristipino@sanfilipponeri.roma.it
authors.forename: Christian
authors.initials: C
authors.lastname: Pristipino
authors.forename: Antonino
authors.initials: A
authors.lastname: Granatelli
authors.forename: Michele
authors.initials: M
authors.lastname: Capasso
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pasceri
authors.forename: Francesco
authors.initials: F
authors.lastname: Pelliccia
authors.forename: Gaia
authors.initials: G
authors.lastname: Orvieto
authors.forename: Fabrizio
authors.initials: F
authors.lastname: D'Errico
authors.forename: Bruno
authors.initials: B
authors.lastname: Pironi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Richichi
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers; D023921:Coronary Stenosis / Q000628:therapy*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D015425:Myocardial Reperfusion; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers