title: Hypertension, and not sex hormones or insulin resistance affects left ventricular mass in aging men.
abstract: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity and mortality. The aim of the study was to find which factors influence left ventricular mass (LVM) and whether relationships exist between sex hormones: testosterone (T), estradiol (E2), sex hormone binding globulin (SHBG) and insulin resistance (HOMA-IR) and LVM. The study group consisted of 107 males at the age of over 50 years (mean 60.1 +/- 7.0). Positive significant correlations between LVM or left ventricle mass index (LVMI) and hypertension (0.23; p = 0.015 and 0.23; p = 0.019 respectively) as well as between LVM and body weight (0.38; p < 0.001) were observed. LVM and LVMI were higher in hypertensive than in normotensive men (279.9 +/- 82.2 vs. 243.4 +/- 70.3 g, p = 0.015 and 144.6 +/- 41.5 vs. 127.4 +/- 33.1 g/m2, p = 0.019 respectively). Multiple regression analysis showed LVM to be independently associated with hypertension and body weight. For LVMI such correlation was found only with hypertension. No relationships were observed between LVM/LVMI and insulin/insulin resistance.
authors.affiliation: Department of Internal Medicine, Skubiszewski Medical University of Lublin.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Barud
authors.forename: Bogusław
authors.initials: B
authors.lastname: Makaruk
authors.forename: Wojciech
authors.initials: W
authors.lastname: Myśliński
authors.forename: Robert
authors.initials: R
authors.lastname: Palusiński
authors.forename: Janusz
authors.initials: J
authors.lastname: Hanzlik
mesh_terms: D000367:Age Factors; D000368:Aged; D001835:Body Weight / Q000502:physiology; D002306:Cardiac Volume / Q000502:physiology; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology; D004452:Echocardiography; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D012739:Gonadal Steroid Hormones