Relation of lower hematocrit to progression from asymptomatic left ventricular dysfunction to symptomatic heart failure (from the Studies of Left Ventricular Dysfunction Prevention trial).
The relation between hematocrit and progression from asymptomatic left ventricular (LV) systolic dysfunction to symptomatic heart failure (HF) was examined in 2,821 patients from the Studies of Left Ventricular Dysfunction Prevention trial. Patients in the lowest hematocrit quartile (hematocrit < or = 40%) were at increased risk for the development of HF symptoms (hazard ratio [HR] 1.79, 95% confidence interval [CI] 1.37 to 2.34), first HF hospitalization (HR 2.35, 95% CI 1.52 to 3.62), and death or the development of HF symptoms (HR 1.60, 95% CI 1.28 to 1.99) compared with patients in the highest hematocrit quartile (hematocrit > 46%).
Das
Sandeep R
SR
Donald W. Reynolds Cardiovascular Clinical Research Center, Dallas, Texas, USA. sandeep.das@utsouthwestern.edu
Dries
Daniel L
DL
Drazner
Mark H
MH
Yancy
Clyde W
CW
Chae
Claudia U
CU
D000368:Aged; D000740:Anemia / Q000097:blood / Q000150:complications*; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006400:Hematocrit; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000097:blood*