Novel brain reactive autoantibodies: prevalence in systemic lupus erythematosus and association with psychoses and seizures.
Autoantibodies can cause neuropsychiatric manifestations in lupus patients by altering the physiological function of neuronal cells. In this study, we identified Brain Reactive Autoantibodies (BRAAs) against murine neuronal membrane proteins (M.W. 27.5 and 29.5 kD) and found them correlating with psychosis and/or seizures in lupus patients. They were specific to neuronal membrane tissues of mammalian origin and are significantly associated with psychosis and/or seizures (p<0.0001). These membrane proteins mass spectrometry profiles did not match to any published protein sequences. These BRAAs may play important roles in the pathophysiology of neuropsychiatric lupus.
Tin
S K
SK
Department of Rheumatology and Immunology, Singapore General Hospital Outram Road, Singapore 169608, Singapore.
Xu
Q
Q
Thumboo
J
J
Lee
L Y
LY
Tse
C
C
Fong
K Y
KY
D000328:Adult; D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000009:adverse effects*; D015153:Blotting, Western / Q000379:methods; D016009:Chi-Square Distribution; D003710:Demography; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D010449:Peptide Mapping / Q000379:methods; D011618:Psychotic Disorders / Q000209:etiology* / Q000276:immunology; D012640:Seizures / Q000209:etiology* / Q000276:immunology; D013045:Species Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods
D001323:Autoantibodies; D008565:Membrane Proteins