title: A preliminary study of breast cancer diagnosis using laboratory based small angle x-ray scattering.
abstract: Breast tissue collected from tumour samples and normal tissue from bi-lateral mastectomy procedures were examined using small angle x-ray scattering. Previous work has indicated that breast tissue disease diagnosis could be performed using small angle x-ray scattering (SAXS) from a synchrotron radiation source. The technique would be more useful to health services if it could be made to work using a conventional x-ray source. Consistent and reliable differences in x-ray scatter distributions were observed between samples from normal and tumour tissue samples using the laboratory based 'SAXSess' system. Albeit from a small number of samples, a sensitivity of 100% was obtained. This result encourages us to pursue the implementation of SAXS as a laboratory based diagnosis technique.
authors.affiliation: Daresbury Laboratories, Warrington, WA4 4AD, UK. A.R.Round@DL.ac.uk
authors.forename: A R
authors.initials: AR
authors.lastname: Round
authors.forename: S J
authors.initials: SJ
authors.lastname: Wilkinson
authors.forename: C J
authors.initials: CJ
authors.lastname: Hall
authors.forename: K D
authors.initials: KD
authors.lastname: Rogers
authors.forename: O
authors.initials: O
authors.lastname: Glatter
authors.forename: T
authors.initials: T
authors.lastname: Wess
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011859:Radiography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014961:X-Ray Diffraction / Q000379:methods*