title: Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.
abstract: In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage.
authors.affiliation: Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
authors.forename: Angela
authors.initials: A
authors.lastname: Falbo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Russo
authors.forename: Achille
authors.initials: A
authors.lastname: Tolino
authors.forename: Fulvio
authors.initials: F
authors.lastname: Zullo
mesh_terms: D000022:Abortion, Spontaneous / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000706:statistics & numerical data; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D010053:Ovary / Q000187:drug effects; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D008687:Metformin