title: Preterm premature rupture of the fetal membranes: current concepts.
abstract: Preterm birth and preterm premature rupture of membranes (PPROM) are common causes of perinatal morbidity and mortality. Fetal membrane integrity is regulated partially by collagenases and inhibitors. A number of genetic polymorphisms with genes related to infection, inflammation and collagen degradation have been identified and studies as risk factors for PPROM. This manuscript reviews the state of the science on the pathophysiology of PPROM and possible genetic influences.
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Srinivas
authors.forename: G A
authors.initials: GA
authors.lastname: Macones
mesh_terms: D000328:Adult; D017209:Apoptosis; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007231:Infant, Newborn; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D020784:Matrix Metalloproteinase 8 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012959:Socioeconomic Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1