Iron imports. I. Intestinal iron absorption and its regulation.
Our knowledge of how the body absorbs iron from the diet and how this process is controlled has increased at a rapid rate in recent years. The identification of key molecules, including the iron regulatory peptide hepcidin, and the analysis of how they are regulated and interact have led to the development of an integrated model for the control of iron absorption by body iron requirements. Research now focuses on the role of the liver as the primary regulator of iron absorption, and this review considers some of the recent highlights and controversies in this area.
Frazer
David M
DM
Iron Metabolism Laboratory, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia.
Anderson
Gregory J
GJ
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D064451:Hepcidins; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D007422:Intestines / Q000502:physiology*; D019266:Iron, Dietary / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism / Q000502:physiology
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D019266:Iron, Dietary