title: Clinical experience with light-emitting diode (LED) photomodulation.
abstract: BACKGROUND
  Light-emitting diode (LED) photomodulation is a novel nonthermal technology used to modulate cellular activity with light.
  
  
  OBJECTIVE
  We describe our experience over the last 2 years using 590 nm LED photomodulation within a dermatologic surgery environment.
  
  
  METHODS
  Practical use of nonthermal light energy and emerging applications in 3,500 treatments delivered to 900 patients is detailed.
  
  
  RESULTS
  LED photomodulation has been used alone for skin rejuvenation in over 300 patients but has been effective in augmentation of results in 600 patients receiving concomitant nonablative thermal and vascular treatments such as intense pulsed light, pulsed dye laser, KTP and infrared lasers, radiofrequency energy, and ablative lasers.
  
  
  CONCLUSIONS
  LED photomodulation reverses signs of photoaging using a new nonthermal mechanism. The anti-inflammatory component of LED in combination with the cell regulatory component helps improve the outcome of other thermal-based rejuvenation treatments.
authors.affiliation: Maryland Laser, Skin and Vein Institute, Hunt Valley, MD 21030, USA. rweiss@mdlaserskin-vein.com
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weiss
authors.forename: David H
authors.initials: DH
authors.lastname: McDaniel
authors.forename: Roy G
authors.initials: RG
authors.lastname: Geronemus
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Weiss
authors.forename: Karen L
authors.initials: KL
authors.lastname: Beasley
authors.forename: Girish M
authors.initials: GM
authors.lastname: Munavalli
authors.forename: Supriya G
authors.initials: SG
authors.lastname: Bellew
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000628:therapy; D005455:Fluorescent Antibody Technique; D015870:Gene Expression; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010789:Phototherapy / Q000295:instrumentation / Q000379:methods*; D012060:Rejuvenation; D015595:Skin Aging / Q000528:radiation effects; D014945:Wound Healing
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid; D020781:Matrix Metalloproteinase 1