title: [Fetal warfarin syndrome in twin pregnancy].
abstract: We describe a pair of twins, whose mother was being treated by oral anticoagulant drugs, as a result of having received mitral heart valve implantation in the past. The male twins monochorionic, monoamniotic--but one infant showed the features of fetal warfarin syndrome. In the study we discussed the pharmacogentetics and individual variation in the human metabolism during treatment with warfarin-perinatal growth and prevalence of congenital malformations. We analysed the threats to the fetus and mother, connected with administration of anticoagulant drugs.
authors.affiliation: Katedra i Klinika Perinatologii i Ginckologii w Zabrzu, SIAM, Katowicach. olejnik@pik-net.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Królak-Olejnik
authors.forename: Antoni
authors.initials: A
authors.lastname: Pyrkosz
authors.forename: Jerzy
authors.initials: J
authors.lastname: Lagan
authors.forename: Ewa
authors.initials: E
authors.lastname: Zembala-Nozyńska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kaźmierczak
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D004200:Diseases in Twins / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D005313:Fetal Death; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008944:Mitral Valve Insufficiency / Q000188:drug therapy; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D011297:Prenatal Exposure Delayed Effects; D014427:Twins; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin