[Correlation analysis of increase in serum level of leptin with that of C reactive protein, troponin T and endothelin in patients with acute myocardial infarction].
OBJECTIVE
To determine serum leptin levels in patients with acute myocardial infarction (AMI) and coronary atherosclerosis (CS), and to analyze its correlation with C reactive protein (CRP), troponin T (TnT) and endothelin (ET).


METHODS
Serum samples from confirmed AMI and CS patients were collected. Leptin and ET were assayed with high sensitive radioimmunoassay, TnT was determined with automatic biochemical analyser, and CRP was determined with enzyme-linked immunosorbant assay (ELISA).


RESULTS
Compared with normal control group, serum leptin, TnT, CRP and ET levels increased significantly (all P<0.01) in AMI patients. Serum levels of other cytokines, except TnT in CS patients, increased significantly compared with normal control group (all P<0.01). Correlation analysis showed that all the changes were not correlated with each other, each being an independent factor. Only serum TnT levels of AMI and CS patients showed a significant difference (P<0.01).


CONCLUSIONS
Serum leptin levels of both AMI and CS patients increase significantly without a significant difference between each other, and there is no correlation for leptin with CRP, TnT and ET.
Yan
Guang-tao
GT
Research Laboratory of Biochemistry, Basic Medical Research Institute, General Hospital of PLA, Beijing 100853, China. YAN301@263.net
Xue
Hui
H
Lin
Ji
J
Hao
Xiu-hua
XH
Zhang
Kai
K
Wang
Lu-huan
LH
D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood; D016232:Endothelins / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood*; D020107:Troponin T / Q000097:blood*
D016232:Endothelins; D020738:Leptin; D020107:Troponin T; D002097:C-Reactive Protein