title: Copper modulates non-enzymatic antioxidants in the freshwater fish Channa punctata (Bloch) exposed to deltamethrin.
abstract: The assessment of the ecotoxicological risks caused by pesticides to ecosystems are based on data on the toxicity and effects of pesticide preparations to non-target organisms like fish. Deltamethrin is a widely used pesticide based on pyrethroids, which is reported to be extremely toxic to fish species. Modulatory effect of copper pre-exposure (10 ppb) on deltamethrin (0.75 microg l-1)-induced oxidative stress was investigated in freshwater fish Channa punctata (Bloch). Non-enzymatic antioxidants were studied as biomarkers of exposure to deltamethrin and possible protection afforded by copper pre-exposure. Glutathione levels were reduced significantly (P<0.05) in liver of copper-acclimatized deltamethrin-exposed group when compared with deltamethrin-exposed groups. The total thiol levels of copper-acclimatized deltamethrin-exposed group was significantly lowered (P<0.01) in liver when compared with deltamethrin-exposed group, while non-protein thiol levels recorded a significant (P<0.01) increase in liver of copper-acclimatized deltamethrin-exposed group when compared with deltamethrin-exposed group. The lipid peroxidation levels of copper-acclimatized deltamethrin-exposed groups were significantly lowered (P<0.01) in liver when compared with deltamethrin-exposed group. Deltamethrin is known to induce toxic responses by generating reactive oxygen species and to neutralize its toxic effect various non-enzymatic antioxidants were found to be modulated thus implicating their role as biomarkers in pollution control programmes.
authors.affiliation: Department of Neurology, University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany. drsuhelparvez@yahoo.com
authors.forename: Suhel
authors.initials: S
authors.lastname: Parvez
authors.forename: Sheikh
authors.initials: S
authors.lastname: Raisuddin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000627:therapeutic use*; D005399:Fishes; D007306:Insecticides / Q000037:antagonists & inhibitors / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D009570:Nitriles / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011722:Pyrethrins / Q000037:antagonists & inhibitors / Q000633:toxicity*; D014131:Trace Elements / Q000627:therapeutic use*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014131:Trace Elements; D014874:Water Pollutants, Chemical; C017180:decamethrin; D003300:Copper