Mucous membrane pemphigoid: an update.
OBJECTIVE
To review articles on mucous membrane pemphigoid, published between June 2004-May 2005.


RESULTS
Decreased glycosylation of mucin was found in patients with ocular cicatricial pemphigoid. A unique antigen in oral mucous membrane pemphigoid has not yet been identified. Increased vascular cell adhesion molecule and intercellular adhesion molecule 1 expression was found in skin of patients affected by mucous membrane pemphigoid. Autoreactive T cells to an epitope of bullous pemphigoid antigen 180 kilodaltons were identified in the blood of some patients with mucous membrane pemphigoid. Circulating IgA against an antigen in mucous membrane pemphigoid was found in about 20% of patients, without prognostic significance. Enhanced sensitivity for direct immunofluorescence was reported if skin biopsy specimens were stored for 24 hours in saline. An enzyme-linked immunosorbent assay for detection of circulating autoantibodies against laminin-5 was developed. Sensitivity was higher than indirect immunofluorescence on salt-split skin and immunoblotting. Patients with younger onset (<60 years) of ocular cicatricial pemphigoid were found to have disease evolution similar to that of an older group (>70 years) but were visually impaired earlier in life. Intravenous immunoglobulin as treatment of ocular cicatricial pemphigoid was found to be superior to conventional immunosuppressants, with fewer side effects and better long-term outcome for halting disease activity. Intraoperative adjunction of mitomycin C during fornix reconstruction with amniotic membrane resulted in achieving a deeper fornix in 83% of patients with various cicatrizing conjunctivitis. Transplantation of cultured epithelial cells of oral mucosa in corneal limbal stem cell deficiency was successful in improving visual acuity and reestablishing corneal transparency in mid- to advanced ocular cicatricial pemphigoid.


CONCLUSIONS
Further advances have been achieved in the field of mucous membrane pemphigoid.
Eschle-Meniconi
Margherita E
ME
Massachusetts Eye Research and Surgery Institute, Boston, Massachusetts, USA, and Medical School of Aga Khan University, Karachi, Pakistan.
Ahmad
Sumera R
SR
Foster
C Stephen
CS
D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D003229:Conjunctival Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D003316:Corneal Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D007070:Immunoglobulin A