beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice.
Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop in the large bowel of aged Apc(Min/+) mice. In this study, we determined the presence and location of BCAC in the large intestine of juvenile Apc(Min/+) mice (3 and 5 weeks of age). Surprisingly, BCAC were noted in the colon of even Apc(Min/+) mice of both ages, and mainly located in the distal and middle segments of the colon. Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice.
Hata
Kazuya
K
BMR Laboratories, Sunplanet Co., Ltd, 4388 Hagiwara, Kamiishidu, Yourou, Gifu 503-1602, Japan.
Tanaka
Takuji
T
Kohno
Hiroyuki
H
Suzuki
Rikako
R
Qiang
Sheng Hong
SH
Yamada
Yasuhiro
Y
Oyama
Takeshi
T
Kuno
Toshiya
T
Hirose
Yoshinobu
Y
Hara
Akira
A
Mori
Hideki
H
D000236:Adenoma / Q000378:metabolism*; D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D017491:Genes, APC / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051176:beta Catenin / Q000378:metabolism*
D051176:beta Catenin