title: Ceriporic acid B, an extracellular metabolite of Ceriporiopsis subvermispora, suppresses the depolymerization of cellulose by the Fenton reaction.
abstract: The white rot fungus, Ceriporiopsis subvermispora, is able to degrade lignin in wood without intensive damage to cellulose. Since lignin biodegradation by white rot fungi proceeds by radical reactions, accompanied by the production of a large amount of Fe3+-reductant phenols and reductive radical species in the presence of iron ions, molecular oxygen, and H2O2, C. subvermispora has been proposed to possess a biological system which suppresses the production of a cellulolytic active oxygen species, *OH, by the Fenton reaction. In the present paper, we demonstrate that 1-nonadecene-2,3-dicarboxylic acid (ceriporic acid B), an extracellular metabolite of C. subvermispora, strongly inhibited *OH production and the depolymerization of cellulose by the Fenton reaction in the presence of iron ions, cellulose, H2O2, and a reductant for Fe3+, hydroquinone (HQ), at the physiological pH of the fungus.
authors.affiliation: Laboratory of Biomass Conversion, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
authors.forename: Noor
authors.initials: N
authors.lastname: Rahmawati
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Takahito
authors.initials: T
authors.lastname: Watanabe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Honda
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D001487:Basidiomycota / Q000378:metabolism*; D002482:Cellulose / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006873:Hydroquinones / Q000737:chemistry; D017665:Hydroxyl Radical; D007477:Ions; D007501:Iron / Q000737:chemistry; D008031:Lignin; D008954:Models, Biological; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D019800:Phenol / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013997:Time Factors
chemical_list: D003998:Dicarboxylic Acids; C045076:Fenton's reagent; D006873:Hydroquinones; D007477:Ions; D011108:Polymers; C506480:ceriporic acid B; D017665:Hydroxyl Radical; D019800:Phenol; D002482:Cellulose; D008031:Lignin; D006861:Hydrogen Peroxide; D007501:Iron; D010100:Oxygen; C031927:hydroquinone