[Lipid lowering drug and other toxic myopathies].
A growing number of therapeutic agents and exogenous toxins are harmful to structure and function of human skeletal muscle. The clinical syndrome encompasses asymptomatic creatine kinase elevation, myalgia, exercise intolerance, muscle paresis and atrophy, and lastly acute rhabdomyolysis. Toxic myopathies are potentially reversible, hence a prompt recognition is particularly helpful for the early diagnosis and in conclusion elimination of a myopathy inducing toxin. Toxic myopathies may be classified as acute or chronic accordingly to the exposition time to a toxin. Main source of an exogenous induced toxic myopathy is chronic alcohol abuse. Alcohol excess induces acute and/or chronic neuropathy and myopathy, consequently muscle wasting and weakness occurs. Drug-induced myopathies are most frequently seen due to amplified utilization of corticosteroids or lipid lowering agents.
Schoser
B G H
BG
Friedrich-Baur-Institut, Neurologische Klinik der Ludwig-Maximilians-Universität München. bschoser@med.uni-muenchen.de
Pongratz
D
D
D064420:Drug-Related Side Effects and Adverse Reactions; D000431:Ethanol / Q000506:poisoning*; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy
D000960:Hypolipidemic Agents; D000431:Ethanol