Syscan3, a kit for detection of anti-Candida antibodies for diagnosis of invasive candidiasis.
Sera from 76 immunocompetent and 293 immunocompromised subjects were assayed for anti-Candida antibodies. The sensitivity, specificity, positive predictive value, and negative predictive value for invasive candidiasis were 74%, 75%, 62%, and 84% in the immunocompetent group and 15%, 60%, 1.7%, and 93% in the immunocompromised group, respectively. Syscan3 has high negative predictive value.
Philip
Annie
A
Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas-Houston Medical School, 77030, USA.
Odabasi
Zekaver
Z
Matiuzzi
Gloria
G
Paetznick
Victor L
VL
Tan
Sze-Wee
SW
Warmington
John
J
Rex
John H
JH
Ostrosky-Zeichner
Luis
L
D000908:Antibodies, Fungal / Q000097:blood*; D000946:Antigens, Fungal / Q000276:immunology; D002175:Candida / Q000145:classification / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D016469:Fungemia / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D011237:Predictive Value of Tests; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D011933:Reagent Kits, Diagnostic