A 10-year-old girl with coexistent moyamoya disease and Graves' disease.
There are rare reports of young women with moyamoya disease associated with Graves' disease; we are unaware of any previous reports of this association in prepubescent girls. We report a 10-year-old girl who presented with multiple bilateral strokes. Cerebral angiography demonstrated moderate to severe stenosis of her bilateral distal internal carotid arteries and proximal anterior and middle cerebral arteries, which was greater on the right. Thyroid function tests demonstrated suppressed thyroid-stimulating hormone and elevated thyroid hormone levels. Serum antiphospholipid antibody screen demonstrated mild elevations of antiocardiolipin IgG. Possible mechanisms predisposing individuals to concurrent moyamoya and Graves' disease are discussed.
Golomb
Meredith R
MR
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Riley Hospital, Indianapolis, Indiana, USA. mgolomb@iupui.edu
Biller
Jose
J
Smith
Jodi L
JL
Edwards-Brown
Mary
M
Sanchez
Juan C
JC
Nebesio
Todd D
TD
Garg
Bhuwan P
BP
D002648:Child; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D009072:Moyamoya Disease / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy