[The value of plasma interleukin-6 and interleukin-8 in monitoring of patients with breast cancer].
The aim of this study was to determine IL-6 and IL-8 in plasma 29 patients with breast cancer in order to evaluate of interleukins in monitoring therapy. These patients were divided into 3 groups. I-control group comprised 25 healthy persons. Group II comprised 14 patients with recently recognized breast cancer. They underwent examination 5 times: before operation, during treatment and follow-up. Group III comprised 15 patients with recurrence cancer. These patients were examined before and after chemotherapy. Before treatment plasma concentration of the IL-6 were increased in 62% and IL-8 in 86% patients. The concentration of IL-6 and IL-8 decreased to normal limits in all patients with remission. In of patients with progressive disease the IL-6 and IL-8 levels decreased during therapy and next rise. The current observations demonstrate that measurements of IL-6 and IL-8 appear to be useful for the evaluation of therapy and monitoring of patients.
Zakrzewska
Irena
I
Zakład Laboratoryjnej Diagnostyki Klinicznej Akademii Medycznej, Białymstoku. irenazakrzewska@wp.pl
Omyła
Jacek
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor; D015850:Interleukin-6; D016209:Interleukin-8