Highly regioselective arylation of sp3 C-H bonds catalyzed by palladium acetate.
A new palladium-catalyzed arylation process based on C-H activation has been developed. The utilization of pyridine-containing directing groups allows the beta-arylation of carboxylic acid derivatives and gamma-arylation of amine derivatives. Both primary and secondary sp3 C-H bonds, as well as sp2 C-H bonds, are reactive.
Zaitsev
Vladimir G
VG
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
Shabashov
Dmitry
D
Daugulis
Olafs
O
D000085:Acetates / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000577:Amides; D010165:Palladium