Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained.
Consolidation theory proposes that through the synthesis of new proteins recently acquired memories are strengthened over time into a stable long-term memory trace. However, evidence has accumulated suggesting that retrieved memory is susceptible to disruption, seeming to consolidate again (reconsolidate) to be retained in long-term storage. Here we show that intracortical blockade of protein synthesis in the gustatory cortex after retrieval of taste-recognition memory disrupts previously consolidated memory to a restricted degree only if the experience is updated. Our results suggest that retrieved memory can be modified as part of a mechanism for incorporating updated information into previously consolidated memory.
Rodriguez-Ortiz
Carlos J
CJ
Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., 04510, México.
De la Cruz
Vanesa
V
Gutiérrez
Ranier
R
Bermudez-Rattoni
Federico
F
D000704:Analysis of Variance; D000818:Animals; D000841:Anisomycin / Q000008:administration & dosage; D001245:Association Learning / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D008845:Microinjections; D010296:Parietal Lobe / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D013649:Taste / Q000502:physiology*
D011500:Protein Synthesis Inhibitors; D000841:Anisomycin