title: A patient-specific computational model of fluid-structure interaction in abdominal aortic aneurysms.
abstract: It is generally believed that knowledge of the wall stress distribution could help to find better rupture risk predictors of abdominal aortic aneurysms (AAAs). Although AAA wall stress results from combined action between blood, wall and intraluminal thrombus, previously published models for patient-specific assessment of the wall stress predominantly did not include fluid-dynamic effects. In order to facilitate the incorporation of fluid-structure interaction in the assessment of AAA wall stress, in this paper, a method for generating patient-specific hexahedral finite element meshes of the AAA lumen and wall is presented. The applicability of the meshes is illustrated by simulations of the wall stress, blood velocity distribution and wall shear stress in a characteristic AAA. The presented method yields a flexible, semi-automated approach for generating patient-specific hexahedral meshes of the AAA lumen and wall with predefined element distributions. The combined fluid/solid mesh allows for simulations of AAA blood dynamics and AAA wall mechanics and the interaction between the two. The mechanical quantities computed in these simulations need to be validated in a clinical setting, after which they could be included in clinical trials in search of risk factors for AAA rupture.
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands. b.j.b.m.wolters@tue.nl
authors.forename: B J B M
authors.initials: BJ
authors.lastname: Wolters
authors.forename: M C M
authors.initials: MC
authors.lastname: Rutten
authors.forename: G W H
authors.initials: GW
authors.lastname: Schurink
authors.forename: U
authors.initials: U
authors.lastname: Kose
authors.forename: J
authors.initials: J
authors.lastname: de Hart
authors.forename: F N
authors.initials: FN
authors.lastname: van de Vosse
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000473:pathology*; D001696:Biomechanical Phenomena; D055592:Biophysical Phenomena; D001703:Biophysics; D001808:Blood Vessels / Q000473:pathology; D002986:Clinical Trials as Topic; D003198:Computer Simulation; D003971:Diastole; D004730:Endothelium, Vascular / Q000473:pathology; D020342:Finite Element Analysis; D018056:Hemorheology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008953:Models, Anatomic; D008954:Models, Biological; D008955:Models, Cardiovascular; D015233:Models, Statistical; D008962:Models, Theoretical; D012307:Risk Factors; D012984:Software; D013314:Stress, Mechanical; D013599:Systole