title: DNase II is a member of the phospholipase D superfamily.
abstract: BACKGROUND
  DNase II is an endodeoxyribonuclease involved in apoptosis and essential for the mammalian development. Despite the understanding of biochemical properties of this enzyme, its structure and relationships to other protein families remain unknown.
  
  
  RESULTS
  Using protein fold-recognition we found that DNase II exhibits a catalytic domain common to the phospholipase D superfamily. Our model explains the available experimental data and provides the first structural platform for sequence-function analyses of this important nuclease.
authors.affiliation: Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warsaw, Poland. iamb@genesilico.pl
authors.forename: Iwona A
authors.initials: IA
authors.lastname: Cymerman
authors.forename: Gregor
authors.initials: G
authors.lastname: Meiss
authors.forename: Janusz M
authors.initials: JM
authors.lastname: Bujnicki
mesh_terms: D000595:Amino Acid Sequence; D003198:Computer Simulation; D004706:Endodeoxyribonucleases / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010739:Phospholipase D / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D011487:Protein Conformation; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
chemical_list: D004706:Endodeoxyribonucleases; C019329:deoxyribonuclease II; D010739:Phospholipase D