Estradiol affects calcium transport across mitochondrial membrane in different brain regions.
The in vitro effect of estradiol on flux of Ca(2+) in the synaptosomal mitochondria from nucleus caudatus and hippocampus of chronically ovariectomized female rats was examined. No effect of estradiol on Ca(2+) influx through ruthenium red-sensitive channels was found. Estradiol, at a concentration of 0.05-5 nmol/L for nucleus caudatus and 0.5-5 nmol/L for the hippocampus, decreased Na-dependent Ca(2+) efflux about 25%.
Petrović
Snjezana
S
Institute of Nuclear Sciences Vinca, Laboratory for Molecular Biology and Endocrinology, Belgrade, Serbia and Montenegro. snjezana5@vin.bg.ac.yu
Demajo
Miroslav
M
Horvat
Anica
A
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012430:Ruthenium Red / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism
D012430:Ruthenium Red; D004958:Estradiol; D012964:Sodium; D002118:Calcium