Expression of the p75 neurotrophin receptor in acute leukaemia.
The dLNGFR is a cytoplasmically deleted form of the low-affinity nerve growth factor receptor (LNGFR, also known as p75NTR). Recently, we observed a myeloid leukaemia in mice transplanted with dLNGFR-modified bone marrow cells. Retroviral-mediated expression of dLNGFR was suspected to contribute to the murine leukaemia. This led us to investigate the expression of p75NTR in human leukaemia. Expression of p75NTR was observed in nine of 119 (8%) adult patients with acute leukaemia by flow cytometry analysis, particularly in acute lymphoblastic leukaemia (26%). These results support further detailed analyses of neurotrophin receptors and downstream signalling pathways in haematological malignancies.
Beutel
Gernot
G
Department of Haematology, Haemostasis and Oncology, Hannover Medical School, Hannover, Germany.
Meyer
Johann
J
Ma
Liping
L
Yin
Songmei
S
Eder
Matthias
M
von Neuhoff
Nils
N
Wilkens
Ludwig
L
Wei
Jing
J
Hertenstein
Bernd
B
Heil
Gerhard
G
Schlegelberger
Brigitte
B
Ganser
Arnold
A
Li
Zhixiong
Z
Baum
Christopher
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D016313:Genes, abl; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D007951:Leukemia, Myeloid / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D020800:Receptor, Nerve Growth Factor / Q000032:analysis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic
D012333:RNA, Messenger; D020800:Receptor, Nerve Growth Factor