title: p53--prognostic factor of malignant transformation of Barrett's esophagus.
abstract: The most significant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformation is determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indication of "preventive" extirpation of the esophagus should be supported by other factors, for example by detection of p53 mutation or expression. The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Department of Surgery, the p53 level and its correlation with histological findings evaluated in these patients. A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlation was also confirmed by detection of early carcinoma in patients with "preventive" extirpation of the esophagus due to a high-grade dysplasia. Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may be helpful for the estimation of malignant potential of the dysplastic mucosa.
authors.affiliation: 1st Clinic of Surgery, Teaching Hospital Olomouc, Czech Republic. rene.aujesky@fnol.cz
authors.forename: René
authors.initials: R
authors.lastname: Aujeský
authors.forename: Marián
authors.initials: M
authors.lastname: Hajdúch
authors.forename: Cestmír
authors.initials: C
authors.lastname: Neoral
authors.forename: Vladimír
authors.initials: V
authors.lastname: Král
authors.forename: Lucie
authors.initials: L
authors.lastname: L'ubusská
authors.forename: Tomás
authors.initials: T
authors.lastname: Bohanes
authors.forename: Jirí
authors.initials: J
authors.lastname: Klein
authors.forename: Radek
authors.initials: R
authors.lastname: Vrba
authors.forename: Petr
authors.initials: P
authors.lastname: Drác
mesh_terms: D001471:Barrett Esophagus / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53