title: Crescentic glomerulonephritis associated with bacterial endocarditis--antibiotics alone may be sufficient. A case report.
abstract: Crescentic glomerulonephritis complicating the course of bacterial endocarditis carries a poor prognosis. Ideal treatment strategy is not clearly defined. In addition to antibiotic treatment, plasmapheresis and steroids have been used with variable results. Here we report a case of 40-year old female who was referred because of generalized body swelling and decrease urine output associated with low grade fever on and off for two to three months. She was diagnosed to have acute renal failure secondary to tricuspid valve endocarditis. Staph aureus was isolated from blood culture and renal biopsy showed crescentic glomerulonephritis. She received dialysis support and antibiotics and had complete recovery of renal function 6 weeks after initiation of therapy. Eradication of infection with antibiotics treatment may be sufficient for resolution of crescentic glomerulonephritis associated with infective endocarditis in some cases.
authors.affiliation: Sindh Institute of Urology and Transplantation, Dow University of Health Sciences and Civil Hospital, Karachi.
authors.forename: Kashif
authors.initials: K
authors.lastname: Manzoor
authors.forename: Saif
authors.initials: S
authors.lastname: Khan
authors.forename: Ejaz
authors.initials: E
authors.lastname: Ahmed
authors.forename: Fazal
authors.initials: F
authors.lastname: Akhter
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mubarak
authors.forename: Syed Ali Anwar
authors.initials: SA
authors.lastname: Naqvi
authors.forename: Adibul Hasan
authors.initials: AH
authors.lastname: Rizvi
mesh_terms: D058186:Acute Kidney Injury; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006435:Renal Dialysis; D013211:Staphylococcus aureus / Q000302:isolation & purification; D014261:Tricuspid Valve / Q000382:microbiology / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D000658:Amoxicillin