[Protective effects of astragali injection on tubular in patients with primary nephrotic syndrome].
OBJECTIVE
To determine the effects of astragali injection on tubular and its possible mechanisms.


METHODS
Sixty patients with primary nephritic syndrome (PNS) were randomly divided into astragali group (n = 30) and control group (n = 30). The surm albumin (sALB) and urinary excretion of retinol-binding protein (RBP), N-Acety-P-beta-Glucosaminidase (NAG), beta2- Microglobulin (beta2MG) were measured before and after the treatment.


RESULTS
After the one month treatment, sALB was significantly higher, and ubeta2MG, uNAG, uRBP, and 24 huP were significantly lower in astragali group (P <0.01, P < 0.05).


CONCLUSIONS
Astragali injection on tubular plays a protective role in PNS.
Chen
Li-Ping
LP
Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China. xyclp@medmail.com.cn
Zhou
Qiao-Ling
QL
Yang
Jing-Hua
JH
D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D027885:Astragalus propinquus; D002648:Child; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D020011:Protective Agents / Q000008:administration & dosage; D012177:Retinol-Binding Proteins / Q000652:urine; D012709:Serum Albumin / Q000032:analysis; D001613:beta 2-Microglobulin / Q000652:urine
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D001613:beta 2-Microglobulin; D000118:Acetylglucosaminidase