title: Aseptic meningitis after intrathecal baclofen injection.
abstract: METHODS
  Two case reports of aseptic meningitis after intrathecal baclofen injection.
  
  
  OBJECTIVE
  To report an unusual complication of intrathecal baclofen injection during test injections.
  
  
  METHODS
  Department of Neurological Rehabilitation, R Poincaré Hôpital (Paris-Ile de France-Ouest University).
  
  
  METHODS
  We present two cases of chemical meningitis after intrathecal baclofen injections by lumbar puncture. These cases presented with febrile meningeal syndromes during the 24 h following intrathecal baclofen injection. Direct cerebrospinal fluid (CSF) examination and CSF cultures were negative. An intense cellular reaction was observed with a marked predominance of neutrophils. Meningitis resolved spontaneously over 3-4 days.
  
  
  CONCLUSIONS
  Chemical meningitis is a rare complication of intrathecal baclofen injections that must be recognized. It is a diagnosis of exclusion and its pathophysiological mechanism remains unclear.
authors.affiliation: Service de Médecine Physique et Réadaptation, Hôpital R Poincaré, Garches, France.
authors.forename: D
authors.initials: D
authors.lastname: Bensmail
authors.forename: A
authors.initials: A
authors.lastname: Peskine
authors.forename: P
authors.initials: P
authors.lastname: Denys
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: B
authors.initials: B
authors.lastname: Bussel
mesh_terms: D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D005260:Female; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal / Q000379:methods; D008582:Meningitis, Aseptic / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D018755:GABA Agonists; D001418:Baclofen