Evaluation of antinociceptive and antiinflammatory activities of the essential oil (EO) of Ocimum micranthum Willd. from Northeastern Brazil.
The EO of Ocimum micranthum was studied for a possible analgesic effect on the acetic acid induced writhing and formalin test in mice and antioedema activities on the carrageenan and dextran induced paw oedema in rats. The EO demonstrated antinociceptive effects, and pretreatment with naloxone did not reverse the antinociception, indicating that the opioid system is not involved. On the other hand, pretreatment with L-arginine (L-arg) reversed the antinociception, suggesting involvement of the nitric oxide (NO) system. The EO did not present an antioedematogenic effect in the carrageenan and dextran models.
Lino
C S
CS
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Cel. Nunes de Melo 1127, 60430-270 Fortaleza-CE, Brazil. cleidelino@yahoo.com.br
Gomes
P B
PB
Lucetti
D L
DL
Diógenes
J P L
JP
Sousa
F C F
FC
Silva
M G V
MG
Viana
G S B
GS
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001120:Arginine / Q000494:pharmacology; D001938:Brazil; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D031339:Ocimum / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009292:Narcotic Antagonists; D009822:Oils, Volatile; D010938:Plant Oils; D009270:Naloxone; D001120:Arginine