title: Colorectal cancer with neuroendocrine differentiation in a child.
abstract: Colorectal cancer is extremely rare in children and presents with a poor prognosis because of the delay in diagnosis and lack of histological differentiation. We report a case of a sigmoid colon carcinoma with areas of neuroendocrine cells in a 12-year-old patient without familial occurrence of colorectal cancer. Symptoms at presentation were anaemia, anorexia, abdominal pain and weight loss. The patient was treated with radical resection and adjuvant chemotherapy. One year later, a local recurrence and hepatic metastases were diagnosed and she underwent chemotherapy and surgical resection. Twenty-six months from initial diagnosis she is alive with evidence of disease. The clinical presentation, diagnosis and treatment of the previously reported cases of colorectal cancer in children are also reviewed.
authors.affiliation: Department of Surgery, University of Milan-Bicocca, San Gerardo Hospital, Monza, MI, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Angelini
authors.forename: Stefano
authors.initials: S
authors.lastname: Crippa
authors.forename: Fabio
authors.initials: F
authors.lastname: Uggeri
authors.forename: Claudia
authors.initials: C
authors.lastname: Bonardi
authors.forename: Paola
authors.initials: P
authors.lastname: Sartori
authors.forename: Franco
authors.initials: F
authors.lastname: Uggeri
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002648:Child; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000032:analysis
chemical_list: D010751:Phosphopyruvate Hydratase