Randomised controlled trial comparing efficacy of same day administration of mifepristone and misoprostol for termination of pregnancy with the standard 36- to 48-hour protocol.
OBJECTIVE
That a 6-hour drug administration interval has similar efficacy and greater patient satisfaction as a 36- to 48-hour interval.


METHODS
Four hundred and fifty patients.


METHODS
A two-arm parallel design unblended randomised controlled trial in a single hospital. Eligible women up to 63 days of gestation will be invited to participate. Those willing will be randomised to either the experimental group (6 hours administration of misoprostol) or the control group (36-48 hours administration of misoprostol). All participants will take 200 mg mifepristone orally. At the time determined by study group allocation 800 microg misoprostol will be given intravaginally together with 100 mg diclofenac pr. Antibiotic prophylaxis as per the usual protocol will be given to each group. The control group will remain in hospital for 6 hours as per current policy and the study group will return home in 1 to 3 hours.


METHODS
Complete medical abortion without need for further misoprostol or surgical evacuation.


RESULTS
Duration of bleeding, side effects and acceptability based on questionnaire.


BACKGROUND
None.
Guest
Jacqueline
J
Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, UK.
Chien
Patrick
P
Thomson
Margaret
M
Kosseim
Marie Louise
ML
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D016595:Misoprostol / Q000008:administration & dosage*; D017060:Patient Satisfaction; D011247:Pregnancy; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000209:etiology
D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone