Interaction of serotonin with Candida albicans selectively attenuates fungal virulence in vitro.
In this study we investigated whether the direct interaction between Candida albicans CBS 5982 and 5-hydroxytryptamine (5-HT) alters candidial virulence. Hyphae elongation, phospholipase activity and the production of secreted aspartyl proteinases (Saps) following 5-HT treatment were investigated. 5-HT treatment of C. albicans significantly (P < 0.05) affected hyphal extension, phospholipase activity and the production of Saps at concentrations of 118-0.46 mM. In conclusion, our findings suggest that the interaction between 5-HT and C. albicans may diminish the virulence properties of this fungal pathogen.
Mayr
A
A
Department of Hygiene, Microbiology and Social Medicine, Division of Hygiene and Medical Microbiology, Medical University Innsbruck, Innsbruck, Austria. astrid.mayr@uibk.ac.at
Hinterberger
G
G
Dierich
M P
MP
Lass-Flörl
C
C
D016282:Aspartic Acid Endopeptidases / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D016166:Free Radical Scavengers / Q000494:pharmacology*; D025301:Hyphae / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010740:Phospholipases / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology*; D037521:Virulence Factors
D016166:Free Radical Scavengers; D037521:Virulence Factors; D012701:Serotonin; D010740:Phospholipases; D016282:Aspartic Acid Endopeptidases