The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia.
The zinc finger and DHHC domain-containing protein 8 (ZDHHC8) gene is located on chromosome 22q11, which several genome scans have provided repeated evidence for a significant linkage with bipolar disorder (BPD) and schizophrenia. A recent study revealed that a single nucleotide polymorphism (SNP), rs175174, which has potential effects on splicing, in intron 4 of the ZDHHC8 gene is associated with susceptibility to patients with schizophrenia in US and South Africa. We examined three SNPs of the ZDHHC8 gene, including rs175174, by case-control association in Japanese patients with BPD (N=172) and controls (N=298) or patients with schizophrenia (N=407) and controls (N=497). No significant association with BPD or schizophrenia was observed. After stratification by subcategories, bipolar I and II of BPD, and paranoid and disorganized types of schizophrenia, no significant association was found, nor was a significant association with either disorder found after dividing by gender. These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.
Otani
Kyohei
K
Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata-cho 2-5-1, Okayama 700-8558, Japan.
Ujike
Hiroshi
H
Tanaka
Yuji
Y
Morita
Yukitaka
Y
Kishimoto
Makiko
M
Morio
Akiko
A
Uchida
Naohiko
N
Nomura
Akira
A
Kuroda
Shigetoshi
S
D000217:Acyltransferases / Q000235:genetics*; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors
D008565:Membrane Proteins; D000217:Acyltransferases; C488097:ZDHHC8 protein, human