Practice implications with an alcohol-free, 0.07% cetylpyridinium chloride mouthrinse.
OBJECTIVE
Behavioral research was conducted to ascertain the relevance of an alcohol-free, 0.07% cetylpyridinium chloride (CPC) therapeutic mouthrinse to contemporary dental practice over a 6-month usage period.


METHODS
A randomized, single-blind study was conducted to assess practice-relevant compliance, acceptability and side effects associated with two mouthrinses. The target population was healthy adult mouthrinse users with a history of routine dental prophylaxis and maintenance care. Subjects were randomly assigned to a therapeutic mouthrinse with 0.07% CPC (Crest Pro-Health Rinse) or a cosmetic rinse control (Scope). Other oral hygiene was not standardized. Subjects completed a questionnaire and were examined by dental hygienists at baseline, and again after 3 and 6 months rinsing. At study completion, a dental prophylaxis was administered.


RESULTS
Compliance was generally favorable, with 273 subjects (89%) completing the 6-month rinsing study. Rinsing time generally stayed the same or increased relative to baseline. Groups differed among the subset who historically used an essential oils rinse (N=137), where those assigned to the alcohol-free therapeutic rinse exhibited significantly (P= 0.02) longer rinsing times compared to subjects using the alcohol-containing cosmetic rinse. Subject evaluations were generally positive with respect to both rinses. Side effects were minimal, with no between-group differences in hygienist-rated calculus or stain accumulation, or prophylaxis time.


CONCLUSIONS
In a 6-month study, a high bioavailable 0.07% CPC therapeutic mouthrinse showed generally high compliance and favorable user acceptability, with similar side effects to those seen with a cosmetic mouthrinse. These findings suggest that the 0.07% CPC mouthrinse may be readily incorporated within the contemporary recall dental practice.
Blenman
Tracie V
TV
Worldwide Clinical Investigations - Oral, The Procter and Gamble Company, Mason, Ohio 45040-9462, USA.
Morrison
Kelly L
KL
Tsau
Grace J
GJ
Medina
Ana L
AL
Gerlach
Robert W
RW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000009:adverse effects / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000009:adverse effects / Q000627:therapeutic use*; D003728:Dental Calculus / Q000145:classification; D003777:Dental Prophylaxis; D004338:Drug Combinations; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D009910:Oral Hygiene; D010349:Patient Compliance; D017060:Patient Satisfaction; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use; D013997:Time Factors; D014075:Tooth Discoloration / Q000145:classification
D000891:Anti-Infective Agents, Local; C505193:Crest Pro-Health mouthrinse; D004338:Drug Combinations; D009067:Mouthwashes; D000644:Quaternary Ammonium Compounds; C094642:Scope mouthwash; D002594:Cetylpyridinium