Ceriporic acid B, an extracellular metabolite of Ceriporiopsis subvermispora, suppresses the depolymerization of cellulose by the Fenton reaction.
The white rot fungus, Ceriporiopsis subvermispora, is able to degrade lignin in wood without intensive damage to cellulose. Since lignin biodegradation by white rot fungi proceeds by radical reactions, accompanied by the production of a large amount of Fe3+-reductant phenols and reductive radical species in the presence of iron ions, molecular oxygen, and H2O2, C. subvermispora has been proposed to possess a biological system which suppresses the production of a cellulolytic active oxygen species, *OH, by the Fenton reaction. In the present paper, we demonstrate that 1-nonadecene-2,3-dicarboxylic acid (ceriporic acid B), an extracellular metabolite of C. subvermispora, strongly inhibited *OH production and the depolymerization of cellulose by the Fenton reaction in the presence of iron ions, cellulose, H2O2, and a reductant for Fe3+, hydroquinone (HQ), at the physiological pH of the fungus.
Rahmawati
Noor
N
Laboratory of Biomass Conversion, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.
Ohashi
Yasunori
Y
Watanabe
Takahito
T
Honda
Yoichi
Y
Watanabe
Takashi
T
D001487:Basidiomycota / Q000378:metabolism*; D002482:Cellulose / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000737:chemistry* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006873:Hydroquinones / Q000737:chemistry; D017665:Hydroxyl Radical; D007477:Ions; D007501:Iron / Q000737:chemistry; D008031:Lignin; D008954:Models, Biological; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D019800:Phenol / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013997:Time Factors
D003998:Dicarboxylic Acids; C045076:Fenton's reagent; D006873:Hydroquinones; D007477:Ions; D011108:Polymers; C506480:ceriporic acid B; D017665:Hydroxyl Radical; D019800:Phenol; D002482:Cellulose; D008031:Lignin; D006861:Hydrogen Peroxide; D007501:Iron; D010100:Oxygen; C031927:hydroquinone