title: Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.
abstract: A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1094 Elkton Road, Newark, DE 19711, USA. george.p.lahm@usa.dupont.com
authors.forename: George P
authors.initials: GP
authors.lastname: Lahm
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Selby
authors.forename: John H
authors.initials: JH
authors.lastname: Freudenberger
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Stevenson
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Myers
authors.forename: Gilles
authors.initials: G
authors.lastname: Seburyamo
authors.forename: Ben K
authors.initials: BK
authors.lastname: Smith
authors.forename: Lindsey
authors.initials: L
authors.lastname: Flexner
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Clark
authors.forename: Daniel
authors.initials: D
authors.lastname: Cordova
mesh_terms: D000586:Amination; D000818:Animals; D002118:Calcium / Q000378:metabolism; D007313:Insecta / Q000187:drug effects; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D019837:Ryanodine Receptor Calcium Release Channel; D062367:ortho-Aminobenzoates; D002118:Calcium