Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities.
Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants approximately 10(5) mol(-1) dm(3); the glycosylated arylacetylide complexes exhibit emission at lambda(max) approximately 620 nm in water and are up to approximately 100-times higher in potency than the clinical cisplatin drug in killing cancer cells.
Ma
Dik-Lung
DL
Department of Chemistry, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Pokfulam Road, Hong Kong.
Shum
Tina Yuen-Ting
TY
Zhang
Fuyi
F
Che
Chi-Ming
CM
Yang
Mengsu
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002945:Cisplatin / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D004591:Electrophoresis, Polyacrylamide Gel; D024202:Electrophoretic Mobility Shift Assay; D006031:Glycosylation; D006801:Humans; D008024:Ligands; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010777:Photochemistry; D011725:Pyridines / Q000138:chemical synthesis*; D015183:Restriction Mapping; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D011725:Pyridines; D004247:DNA; D002945:Cisplatin