Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells.
Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin molecules, which were connected by a C-C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50values of 23.4, 22.9, 29.0, and 23.3 microM, respectively.
Quang
Dang Ngoc
DN
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
Hashimoto
Toshihiro
T
Arakawa
Yuuki
Y
Kohchi
Chie
C
Nishizawa
Takashi
T
Soma
Gen-Ichiro
G
Asakawa
Yoshinori
Y
D000818:Animals; D002460:Cell Line; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013057:Spectrum Analysis / Q000379:methods; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
D013729:Terpenes; D009569:Nitric Oxide; C058858:grifolin