Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping.
The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach.
Chen
Zehua
Z
Department of Statistics and Applied Probability, National University of Singapore, Republic of Singapore. stachenz@nus.edu.sg
Zheng
Gang
G
Ghosh
Kaushik
K
Li
Zhaohai
Z
D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D040641:Quantitative Trait Loci