[Rosacea fulminans, pyostomatitis and pyovulvitis in Crohn's disease: dapsone as key factor in combination therapy].
Rosacea fulminans (also known as pyoderma faciale) has been reported to occur in association with Crohn's disease. It is still unclear whether the papulopustules and confluent nodules of rosacea fulminans represent a manifestation of mucocutaneous Crohn's disease or whether this association is a mere coincidence. A 46-year-old woman presented with the spontaneous outbreak of rosacea fulminans and pyostomatitis/pyovulvitis. Complete remission of the mucocutaneous symptoms was achieved with 2 months combination therapy with methylprednisolone, isotretinoin and dapsone. The patient's Crohn's disease, already diagnosed for 3 years, did not flare during this period.
Gatzka
M
M
Hautklinik, Universitätsklinikum Erlangen, Germany.
Simon
M
M
Schuler
G
G
Lüftl
M
M
D000890:Anti-Infective Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D003622:Dapsone / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage*; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D012393:Rosacea / Q000150:complications / Q000188:drug therapy*; D013280:Stomatitis / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome; D014847:Vulvitis / Q000150:complications / Q000188:drug therapy*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D004338:Drug Combinations; D003622:Dapsone; D015474:Isotretinoin; D008775:Methylprednisolone