Expedient parallel synthesis of 2-amino-4-heteroarylpyrimidines.
[reaction: see text] An expedient synthesis of diverse 2-amino-4-heteroarylpyrimidines via a 2-chloropyrimidine intermediate is described. A series of potentially biologically active analogues have been synthesized in two parallel steps to afford focused arrays.
Bursavich
Matthew G
MG
Exploratory Medicinal Chemistry, Chemical and Screening Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. bursavm@wyeth.com
Lombardi
Sabrina
S
Gilbert
Adam M
AM
D000586:Amination; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry*
D011743:Pyrimidines