Elevated Serum Levels of Osteopontin in HCV-Associated Lymphoproliferative Disorders.
Hepatitis C virus (HCV) infection is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Recent evidences have also suggested that HCV infection contributes to development of autoimmune disorders and B-cell nonHodgkin's lymphoma (NHL). Mechanisms by which HCV infection promotes B-cell NHL development remain unclear. Increased serum osteopontin (OPN) levels have been associated with several autoimmune diseases as well as a variety of cancers. However, the association between OPN and B-cell NHL or HCV-associated B-cell proliferation has not previously been reported. In the present study, we determined whether serum OPN differences were associated with HCV infection, type II mixed cryglobulinemia (MC) syndrome and B-cell NHL. Serum OPN levels were measured by capture enzyme-linked immunosorbent assay. Our results show that high serum OPN levels are associated with B-cell NHL and HCV infection. Interestingly, highest serum OPN concentrations were found among HCV-infected patients with concomitant type II MC syndrome with and without B-cell NHL. These data indicate that OPN is involved in the lymphomagenesis, especially, in the context of HCV infection and autoimmune diseases.
Libra
Massimo
M
Department of Biomedical Sciences, University of Catania, Catania, Italy.
Indelicato
Manuela
M
De Re
Vallì
V
Zignego
Anna Linda
AL
Chiocchetti
Annalisa
A
Malaponte
Grazia
G
Dianzani
Umberto
U
Nicoletti
Ferdinando
F
Stivala
Franca
F
McCubrey
James A
JA
Mazzarino
Maria C
MC
D016022:Case-Control Studies; D003449:Cryoglobulinemia / Q000097:blood / Q000150:complications / Q000821:virology*; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000097:blood / Q000150:complications* / Q000821:virology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood / Q000145:classification / Q000150:complications / Q000821:virology*; D008297:Male; D008875:Middle Aged; D053495:Osteopontin; D012367:RNA, Viral / Q000097:blood; D012795:Sialoglycoproteins / Q000097:blood*
D012367:RNA, Viral; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin