title: Antimycins A10 approximately A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893.
abstract: Seven new antimycin antibiotics, named antimycins A10, A11, A12, A13, A14, A15 and A16, were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A1, A2, A3 and A4. The structures of the new antimycins were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited antifungal activity against Candida utilis.
authors.affiliation: Exploratory Research Group, Research Division, Sumitomo Pharmaceuticals Co Ltd, 4-2-1 Takatsukasa, Takarazuka, Hyogo 665-0051, Japan. hosotani@sumitomopharm.co.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hosotani
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kumagai
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimatani
authors.forename: Ikutaro
authors.initials: I
authors.lastname: Saji
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000968:Antimycin A / Q000031:analogs & derivatives*; D002175:Candida / Q000187:drug effects; D005285:Fermentation; D015394:Molecular Structure; D013302:Streptomyces / Q000145:classification*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000968:Antimycin A