title: Successful treatment of Paecilomyces variotii splenic abscesses: a rare complication in a previously unrecognized chronic granulomatous disease child.
abstract: A case of splenic abscesses caused by Paecilomyces variotii in a 21-month-old child with previously undiagnosed chronic granulomatous disease (CGD) is described. An X-linked form of CGD with deficiency of gp91-phox was diagnosed. The fungal pathogen was isolated from the abscess contents. Cure was achieved by a partial splenectomy and a prolonged fluconazole and flucytosine combination treatment regimen. P. variotii is an emerging fungus in children with CGD. Every effort should be made to recover the possible underlying immunodeficiency in children with paecilomycosis.
authors.affiliation: Department of Emergency Medicine, National Cheng Kung University and Hospital, Tainan 70428, Taiwan.
authors.forename: Shih-Min
authors.initials: SM
authors.lastname: Wang
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Shieh
authors.forename: Ching-Chuan
authors.initials: CC
authors.lastname: Liu
mesh_terms: D000038:Abscess / Q000209:etiology / Q000382:microbiology*; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D009181:Mycoses / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D010143:Paecilomyces; D013154:Spleen / Q000382:microbiology*