Benign fibroblastic polyp of the colorectum.
OBJECTIVE
We present the clinicopathologic features, endoscopic appearance, and ultrastructure of a newly described mesenchymal polyp of the colorectum, termed benign fibroblastic polyp.


METHODS
A total of 4 cases from our institution are analyzed using routine histopathology, immunohistochemistry, and electron microscopy, and compared with the original series of 14 cases previously described in the pathology literature.


RESULTS
Benign fibroblastic polyps appear endoscopically throughout the colorectum as submucosal lesions with a hyperplastic surface component. These lesions are histologically and ultrastructurally distinct, but overlap with other mesenchymal polyps warrants additional immunohistochemical studies for definitive classification.


CONCLUSIONS
Benign fibroblastic polyps of the colorectum comprise a recently described distinct entity of mesenchymal polyps that appear to follow an indolent clinical course. Their etiology is uncertain but may be linked to an exuberant tissue response following mucosal injury. Gastroenterologists should be aware of this new entity that will be increasingly diagnosed by pathologists.
Kalof
Alexandra N
AN
Department of Pathology, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Pritt
Bobbi
B
Cooper
Kumarasen
K
Hyman
Neil H
NH
Blaszyk
Hagen
H
D000199:Actins / Q000378:metabolism; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D003111:Colonic Polyps / Q000378:metabolism / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005347:Fibroblasts; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D007150:Immunohistochemistry; D007417:Intestinal Polyps / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012002:Rectal Diseases / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism
D000199:Actins; D018952:Antigens, CD34; D015415:Biomarkers; D009418:S100 Proteins; D019009:Proto-Oncogene Proteins c-kit