Type 2 diabetes mellitus complicated with smoldering myeloma and non-alcoholic steatohepatitis.
We report a 59-year-old woman with type 2 diabetes mellitus (DM) complicated with smoldering myeloma and non-alcoholic steatohepatitis. A diagnosis of smoldering myeloma was made on the basis of elevation of IgA, M-protein (type:IgA-lambda) and histological findings of bone marrow without bone lesion. As to liver dysfunction, anti-HBV, anti-HCV and a series of auto-immune antibody were negative. She had no alcohol drinking habit and histological findings showed pericellular fibrosis without fatty degeneration, suggesting liver cirrhosis due to non-alcoholic steatohepatitis (NASH). To date, there are no reports of cases with DM, NASH and myeloma. Particular attention may be necessary for these complications.
Nakahara
Takehiro
T
Division of Internal Medicine, Gunma University Hospital, Maebashi, Japan.
Utsugi
Toshihiro
T
Ohyama
Yoshio
Y
Tomono
Shoichi
S
Sato
Ken
K
Takagi
Hitoshi
H
Murakami
Hirokazu
H
Hasegawa
Akira
A
Kurabayashi
Masahiko
M
D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005234:Fatty Liver / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors