Protective effect of peroxisome proliferator activated receptor gamma agonists on diabetic and non-diabetic renal diseases.
Peroxisome proliferator activated receptor gamma (PPARgamma) agonist has not only antidiabetic effect but also a protective effect against various types of injury of the kidney. The protective effects of PPARgamma agonists are observed in diabetic nephropathy and non-diabetic renal diseases such as 5/6 ablation model of renal failure, experimental glomerulonephritis, ischemia-reperfusion injury, hypertensive nephropathy and cyclosporin-induced renal injury. The mechanism of renoprotection by PPARgamma agonist is multifactorial. Anti-fibrotic and anti-inflammatory effects, suppression of renin-angiotensin system, vascular protective effect and antiapoptotic effect were proposed.
Chung
Byung Ha
BH
Xenotransplantation Center and Cell Death Research Center, Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
Lim
Sun Woo
SW
Ahn
Kyung Ohk
KO
Sugawara
Akira
A
Ito
Sadayoshi
S
Choi
Bum Soon
BS
Kim
Yong Soo
YS
Bang
Byung Kee
BK
Yang
Chul Woo
CW
D000818:Animals; D019610:Cytoprotection; D003928:Diabetic Nephropathies / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D047495:PPAR gamma / Q000819:agonists*
D047495:PPAR gamma