Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery.
Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and "lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs).
Picquet
Erwann
E
UMR CNRS 6521, UFR Sciences et Techniques, Université de Bretagne Occidentale, 6, Av. Le Gorgeu, C.S. 93837, F-29238 Brest Cedex 3, France.
Le Ny
Karine
K
Delépine
Pascal
P
Montier
Tristan
T
Yaouanc
Jean-Jacques
JJ
Cartier
Dominique
D
des Abbayes
Hervé
H
Férec
Claude
C
Clément
Jean-Claude
JC
D000577:Amides / Q000737:chemistry*; D000818:Animals; D002412:Cations / Q000737:chemistry; D002460:Cell Line; D006224:Cricetinae; D004247:DNA / Q000008:administration & dosage* / Q000235:genetics; D018014:Gene Transfer Techniques / Q000295:instrumentation*; D017930:Genes, Reporter / Q000235:genetics; D005822:Genetic Vectors / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D063088:Phosphoramides; D010756:Phosphoric Acids / Q000737:chemistry*; D010766:Phosphorylation
D000577:Amides; D002412:Cations; D006146:Guanidines; D008055:Lipids; D063088:Phosphoramides; D010756:Phosphoric Acids; C005438:phosphoramide; D004247:DNA