title: [Expression of gastrin and gastrin releasing peptide in patient's with gastric cancer by using tissue chip technique].
abstract: OBJECTIVE
  To study the expression of gastrin(GAS) and gastrin releasing peptide(GRP) in patients with gastric cancer and investigate the clinical significance.
  
  
  METHODS
  The expression of GAS and GRP in sixty patients with gastric cancer was detected by using tissue chip technique and immunohistochemical methods.
  
  
  RESULTS
  The positive rates of GAS and GRP were 30.0% and 11.7% respectively in 60 cases with gastric cancer. The positive rates of GAS and GRP were higher in moderately and poorly differentiated cancers than those in well differentiated cancer (P< 0.05). The positive rates of GAS and GRP were significantly higher in mucinous adenocarcinoma and signet-ring cell carcinoma than those in other types of gastric cancer (P< 0.05). The positive expression of GAS and GRP in gastric cancer was correlated with lymph node metastasis (P< 0.05).
  
  
  CONCLUSIONS
  Tissue chip technique is a feasible,rapid,economic and accurate approach for screening clinical tissue specimens on a large scale.
authors.affiliation: Department of Pathology, Jiangxi Provincial People's Hospital, Nanchang, China.
authors.forename: Ming-zhi
authors.initials: MZ
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yan-zhi
authors.initials: YZ
authors.lastname: Dai
authors.forename: Cheng
authors.initials: C
authors.lastname: Yuan
authors.forename: Yu
authors.initials: Y
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019886:Gastrin-Releasing Peptide / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D040081:Protein Array Analysis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D005755:Gastrins; D019886:Gastrin-Releasing Peptide