[The supramolecular organization and functions creatine kinase of system].
The Creatine kinase (CK) SYSTEM represents key in a power exchange mediators the structure capable to plural interactions with the majority energy making (Glycolysis and mitochondriuns) and energy consuming (ATPases) structures at use of one multifunctional metabolits--creatine and providing transport macroergs inside a cell. Mitochondrions CK provides synthesis creatine phosphates (CP) from cytoplasmic creatine and energy mitochondriums ATP. CP energetically also is structurally more favourable than ATphi. The MM, MB and BB isoforms provide splitting Kphi and synthesis ATphi for M-ATPases, Ca-ATPases and Na-K-ATPases accordingly. Questions of regulation of activity of enzyme, both in ontogenesis, and in blood are discussed.
Roslyĭ
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Abramov
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D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003401:Creatine / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology*; D010725:Phosphocreatine / Q000096:biosynthesis*
D007527:Isoenzymes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D003402:Creatine Kinase; D000251:Adenosine Triphosphatases; D003401:Creatine