Gene therapy progress and prospects: viral trafficking during infection.
The intracellular steps involved in viral infection, namely cytoplasmic trafficking and nuclear import, are critical events in the viral life cycle that have lagged behind other areas of viral research. This review examines recent advances in our understanding of these steps for viruses commonly employed as viral gene delivery vectors. Steps governing the cytoplasmic trafficking and nuclear import of Herpes Simplex virus, Human Immunodeficiency virus and Adenovirus are reviewed in this article.
Campbell
E M
EM
Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S. Wolcott Rm. E-703, Chicago, IL 60612, USA.
Hope
T J
TJ
D000256:Adenoviridae / Q000502:physiology; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism / Q000821:virology; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000008:administration & dosage*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D021381:Protein Transport; D018139:Simplexvirus / Q000502:physiology; D014161:Transduction, Genetic / Q000379:methods*; D014764:Viral Proteins / Q000378:metabolism*; D014777:Virus Diseases / Q000378:metabolism*
D014764:Viral Proteins