title: A new option for early breast cancer patients previously irradiated for Hodgkin's disease: intraoperative radiotherapy with electrons (ELIOT).
abstract: BACKGROUND
  Patients who have undergone mantle radiotherapy for Hodgkin's disease (HD) are at increased risk of developing breast cancer. In such patients, breast conserving surgery (BCS) followed by breast irradiation is generally considered contraindicated owing to the high cumulative radiation dose. Mastectomy is therefore recommended as the first option treatment in these women.
  
  
  METHODS
  Six patients affected by early breast cancer previously treated with mantle radiation for HD underwent BCS associated with full-dose intraoperative radiotherapy with electrons (ELIOT).
  
  
  RESULTS
  A total dose of 21 Gy (prescribed at 90% isodose) in five cases and 17 Gy (at 100% isodose) in one case were delivered directly to the mammary gland without acute complications and with good cosmetic results. After an average of 30.8 months of follow up, no late sequelae were observed and the patients are free of disease.
  
  
  CONCLUSIONS
  In patients previously irradiated for HD, ELIOT can avoid repeat irradiation of the whole breast, permit BCS and decrease the number of avoidable mastectomies.
authors.affiliation: Department of Breast Surgery, European Institute of Oncology, Milan, Italy. mattia.intra@ieo.it
authors.forename: Mattia
authors.initials: M
authors.lastname: Intra
authors.forename: Oreste
authors.initials: O
authors.lastname: Gentilini
authors.forename: Paolo
authors.initials: P
authors.lastname: Veronesi
authors.forename: Mario
authors.initials: M
authors.lastname: Ciocca
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.forename: Roberta
authors.initials: R
authors.lastname: Lazzari
authors.forename: Javier
authors.initials: J
authors.lastname: Soteldo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Farante
authors.forename: Roberto
authors.initials: R
authors.lastname: Orecchia
authors.forename: Umberto
authors.initials: U
authors.lastname: Veronesi
mesh_terms: D003131:Combined Modality Therapy; D004583:Electrons / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D007432:Intraoperative Period; D016609:Neoplasms, Second Primary / Q000532:radiotherapy* / Q000601:surgery*; D010315:Particle Accelerators; D011879:Radiotherapy Dosage