title: Expression of the p75 neurotrophin receptor in acute leukaemia.
abstract: The dLNGFR is a cytoplasmically deleted form of the low-affinity nerve growth factor receptor (LNGFR, also known as p75NTR). Recently, we observed a myeloid leukaemia in mice transplanted with dLNGFR-modified bone marrow cells. Retroviral-mediated expression of dLNGFR was suspected to contribute to the murine leukaemia. This led us to investigate the expression of p75NTR in human leukaemia. Expression of p75NTR was observed in nine of 119 (8%) adult patients with acute leukaemia by flow cytometry analysis, particularly in acute lymphoblastic leukaemia (26%). These results support further detailed analyses of neurotrophin receptors and downstream signalling pathways in haematological malignancies.
authors.affiliation: Department of Haematology, Haemostasis and Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: Gernot
authors.initials: G
authors.lastname: Beutel
authors.forename: Johann
authors.initials: J
authors.lastname: Meyer
authors.forename: Liping
authors.initials: L
authors.lastname: Ma
authors.forename: Songmei
authors.initials: S
authors.lastname: Yin
authors.forename: Matthias
authors.initials: M
authors.lastname: Eder
authors.forename: Nils
authors.initials: N
authors.lastname: von Neuhoff
authors.forename: Ludwig
authors.initials: L
authors.lastname: Wilkens
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.forename: Bernd
authors.initials: B
authors.lastname: Hertenstein
authors.forename: Gerhard
authors.initials: G
authors.lastname: Heil
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlegelberger
authors.forename: Arnold
authors.initials: A
authors.lastname: Ganser
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Li
authors.forename: Christopher
authors.initials: C
authors.lastname: Baum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005434:Flow Cytometry; D015870:Gene Expression; D016313:Genes, abl; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D007951:Leukemia, Myeloid / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D020800:Receptor, Nerve Growth Factor / Q000032:analysis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic
chemical_list: D012333:RNA, Messenger; D020800:Receptor, Nerve Growth Factor