Burkholderia gladioli osteomyelitis in association with chronic granulomatous disease: case report and review.
We describe a case of insidious small bone osteomyelitis and soft tissue abscess with Burkholderia gladioli in a 6-year-old Caucasian boy with chronic granulomatous disease. DNA sequencing of the 16S ribosomal RNA gene confirmed the bacterial identification. Clinical cure was achieved with a combination of antimicrobial therapy and surgical debridement. A review of infections caused by Burkholderia spp., other than Burkholderia cepacia complex, in pediatric patients with chronic granulomatous disease is provided.
Boyanton
Bobby L
BL
Department of Pathology, Baylor College of Medicine, Houston, TX, USA.
Noroski
Lenora M
LM
Reddy
Hari
H
Dishop
Megan K
MK
Hicks
M John
MJ
Versalovic
James
J
Moylett
Edina H
EH
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019121:Burkholderia Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D042725:Burkholderia gladioli / Q000302:isolation & purification*; D002648:Child; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D012336:RNA, Ribosomal, 16S / Q000032:analysis / Q000235:genetics; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S