title: [125-I brachytherapy of pineal parenchymal tumours in two patients and review of the literature].
abstract: BACKGROUND
  Pineal parenchymal tumours make up 0.3% of all brain tumours. Stereotactic biopsy has by now become an indispensable method to detect these tumours and it can be safely performed.
  
  
  METHODS
  Two patients with pineoblastoma were treated with 125I brachytherapy. The MRI and CT images taken 15 and 18 months after irradiation showed significant tumour shrinkage.
  
  
  RESULTS
  Tumour volume was 0.76 cm3 in the control CT image in Case 1, a shrinkage by 73% compared to 2.87 cm3 measured at the time of planning the interstitial irradiation. In Case 2, tumour volume measured on the control MRI examination was 0.29 cm3 as opposed to 1.27 cm3 of original tumour volume, which represents a 77% shrinkage.
  
  
  CONCLUSIONS
  The insertion of isotope seeds was performed at the same time as the biopsy, because thus the knowledge of the histological diagnosis could spare the patients from a second stereotactic intervention. The CT- and image fusion guided 125I stereotactic brachytherapy is a procedure that can be dosimetrically precisely planned and surgically accurately and safely performed.
authors.affiliation: Fovárosi Onkormányzat, Szent János Kórház és Rendelointézet, Idegsebészeti Osztály, Budapest.
authors.forename: Jeno
authors.initials: J
authors.lastname: Julow
authors.forename: Arpád
authors.initials: A
authors.lastname: Viola
authors.forename: Tibor
authors.initials: T
authors.lastname: Major
authors.forename: István
authors.initials: I
authors.lastname: Valálik
authors.forename: Sarolta
authors.initials: S
authors.lastname: Sági
authors.forename: László
authors.initials: L
authors.lastname: Mangel
authors.forename: Rita Beáta
authors.initials: RB
authors.lastname: Kovács
authors.forename: János
authors.initials: J
authors.lastname: Hável
authors.forename: Tibor
authors.initials: T
authors.lastname: Kiss
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D002408:Catheters, Indwelling; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010870:Pineal Gland; D010871:Pinealoma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes