Histopathological changes of biopsied myocardium in Shoshin beriberi.
Cardiovascular beriberi is caused by thiamine deficiency and usually arises for one of two reasons: alcoholism or diet. Shoshin beriberi is a fulminant form of cardiac beriberi. We investigated the histopathological features of biopsied myocardial tissue samples from two patients with Shoshin beriberi (one patient with nonalcoholic beriberi and another patient with alcoholic beriberi). Interstitial fibrosis and a variation in size of the myocardial fibers were the main findings in the sample from these patients after thiamine treatment. These findings are persistent histopathological features in the myocardium of patients with Shoshin beriberi after thiamine treatment.
Kawano
Hiroaki
H
Department of Cardiovascular Medicine, Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University, Nagasaki 852-8501, Japan.
Hayashi
Tomayoshi
T
Koide
Yuji
Y
Toda
Genji
G
Yano
Katsusuke
K
D001602:Beriberi / Q000188:drug therapy / Q000473:pathology*; D001706:Biopsy; D009202:Cardiomyopathies / Q000473:pathology*; D002310:Cardiomyopathy, Alcoholic / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D013831:Thiamine / Q000627:therapeutic use
D013831:Thiamine