title: High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: synthesis and characterization.
abstract: The synthesis of a novel iron(III)-selective hydroxypyridinone hexadentate-terminated dendritic chelator based on a benzene tricarbonyl core polyamine dendrimer is described. The iron-chelating ability of the dendritic chelator was demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and UV-vis spectroscopy. The physicochemical properties of the isolated hexadentate unit were also investigated. The dendrimer was found to possess an extremely high affinity for iron(III), namely logK=34.8, pFe3+=30.6.
authors.affiliation: Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Zu Dong
authors.initials: ZD
authors.lastname: Liu
authors.forename: Hendrik
authors.initials: H
authors.lastname: Neubert
authors.forename: Xiao Le
authors.initials: XL
authors.lastname: Kong
authors.forename: Yong Min
authors.initials: YM
authors.lastname: Ma
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
mesh_terms: D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D007502:Iron Chelating Agents; D011725:Pyridines; C506370:hexadentate 3-hydroxypyridin-4-one; D007501:Iron