Solution-phase parallel synthesis of a 1,2,7-trialkyl-1H-imidazo[4,5-g]quinoxalin-6-ol library scaffold.
This paper describes solution-phase parallel synthesis of a library with a novel 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-ol scaffold and three points of diversity. The library is prepared using 1,5-difluoro-2,4-dinitrobenzene as the starting material and commercially available chemicals as the building blocks. A new, inexpensive, and practical apparatus for parallel filtration is also described.
Zhang
Jing
J
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
Zhang
Liang
L
Zhang
Suode
S
Wang
Yinghong
Y
Liu
Gang
G
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D005374:Filtration / Q000295:instrumentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry
D011810:Quinoxalines