[Study on the relationship between blood stasis syndrome and clinical pathology in patients with IgA nephropathy].
OBJECTIVE
To explore the relationship between blood stasis Syndrome and clinical pathological parameters in patients with IgA nephropathy (IgAN).


METHODS
The clinicopathological data were analyzed of 94 IgAN patients of traditional Chinese medicine blood stasis syndrome.


RESULTS
Of the 94 IgAN patients, 61.70% had blood stasis syndrome (BS) and 38.30% had non- blood stasis syndrome (non-BS). In patients with BS, dark purple tongue proper was the symptom most commonly seen; the clinical manifestations were mostly proteinuria with hematuria, often accompanied with hypertension and renal dysfunction. Compared with those in patients without BS, plasma levels of serum creatinine (SCr), triglyceride (TG) and plasma fibrinogen (FIB) were obviously higher, activated partial thromboplastin time (APTT), and urokinase-type plasminogen activators (u-PA) significantly lower; and scores of glomerular sclerosis, tubular interstitial lesions, interstitial inflammatory cell infiltration, interstitial fibrosis, tubular atrophy and vascular sclerosis significantly higher. Besides, the Lee's grades in them of III - V were mostly seen.


CONCLUSIONS
Blood stasis syndrome of IgAN are correlated with certain clinical parameters and severity of renal pathological changes. The combination of TCM holistic syndrome differentiation and modern medicinal micro-differentiation is more favorable for making clear the nature of blood stasis Syndrome of IgAN.
Wei
Cheng-Yun
CY
Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing. weichengyun2004@yahoo.com.cn
Chen
Xiang-Mei
XM
Zhao
Dan-Yang
DY
Zhuang
Yongze
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D001775:Blood Circulation; D001809:Blood Viscosity; D003937:Diagnosis, Differential; D005260:Female; D005922:Glomerulonephritis, IGA / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D006417:Hematuria / Q000473:pathology; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D011507:Proteinuria / Q000473:pathology