An ancient control of epithelial barrier formation and wound healing.
Animal epithelia are lined with apical surface matrices, which protect against pathogens, dehydration and physical damage of the underlying cells. The proteins and polysaccharides that comprise these protective barriers vary greatly within the animal kingdom and have evolved in response to the biological needs of various organisms. Yet the genetic control of barrier formation and its regeneration upon wounding appears conserved between vertebrates and insects that are evolutionary more than several hundred millions of years apart. A key role is carried out by Grainy head, a phylogenetically conserved transcription factor expressed in epidermal cells in nematodes, flies, frogs, mice and humans.
Moussian
Bernard
B
Max-Planck-Institut fuer Entwicklungsbiologie, Tuebingen, Germany.
Uv
Anne E
AE
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004848:Epithelium / Q000033:anatomy & histology* / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014945:Wound Healing
D004268:DNA-Binding Proteins; D020033:Protein Isoforms; D014157:Transcription Factors