Autonomic function after botulinum toxin type A or B: a double-blind, randomized trial.
To compare autonomic effects of botulinum toxin (BTX), we randomized patients with cervical dystonia to receive either BTX-A or BTX-B in a double-blind manner. Efficacy and physiologic questionnaire measures of autonomic function were assessed at baseline and 2 weeks after injection. Patients treated with BTX-B had less saliva production (p < 0.01) and greater severity of constipation (p = 0.037) than those treated with BTX-A, but did not differ in other tests of autonomic functions.
Tintner
R
R
Department of Neurology, Baylor College of Medicine, Houston, TX, USA. rtintner@tmh.tmc.edu
Gross
R
R
Winzer
U F
UF
Smalky
K A
KA
Jankovic
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000009:adverse effects*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002799:Cholinergic Fibers / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D017615:Enteric Nervous System / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects; D017729:Presynaptic Terminals / Q000187:drug effects / Q000502:physiology; D012025:Reflex, Pupillary / Q000187:drug effects / Q000502:physiology; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D014103:Torticollis / Q000188:drug therapy*
D009465:Neuromuscular Agents; C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A