title: Effects of short-term supplementation with folic acid on different oxidative stress parameters in patients with hypertension.
abstract: Oxidative stress seems to play an important role in the pathophysiology of essential hypertension. Due to its antioxidant features, we studied the protective action of folic acid in hypertensive patients, their food supplemented for 2 weeks with this vitamin. Several oxidative stress parameters were measured in the serum of these patients. The results show that folic acid supplementation improves levels of oxidative stress markers in individuals with hypertension, overall in those patients whose initial parameter values were highest.
authors.affiliation: Unidad de Hipertension y Lipidos, Departamento de Medicina Interna, Hospitales Universitarios Virgen del Rocio, Seville, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Stiefel
authors.forename: Sandro
authors.initials: S
authors.lastname: Argüelles
authors.forename: Sonia
authors.initials: S
authors.lastname: García
authors.forename: Luis
authors.initials: L
authors.lastname: Jiménez
authors.forename: Reyes
authors.initials: R
authors.lastname: Aparicio
authors.forename: Joaquín
authors.initials: J
authors.lastname: Carneado
authors.forename: Alberto
authors.initials: A
authors.lastname: Machado
authors.forename: Antonio
authors.initials: A
authors.lastname: Ayala
mesh_terms: D000328:Adult; D000368:Aged; D019587:Dietary Supplements; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000178:diet therapy / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014803:Vitamin B Complex / Q000008:administration & dosage* / Q000097:blood
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D006710:Homocysteine; D014803:Vitamin B Complex; D005492:Folic Acid