Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis.
OBJECTIVE
To report the presence of HIV-1-infected patients with bilateral panuveitis, CD8 lymphocytosis, and an absence of parotid involvement.


METHODS
Case series of four HIV-1-infected patients naive to antiretroviral treatment.


RESULTS
Four patients with symptomatic panuveitis are presented. Ocular, systemic, and investigation findings are reported. Recognised causes of panuveitis were excluded. All patients showed a clinical response to steroids and antiretroviral therapy.


CONCLUSIONS
Symptomatic panuveitis may occur in HIV-1-infected individuals with CD8 lymphocytosis in the absence of a recognised cause. These patients have clinical features that resemble diffuse infiltrative lymphocytosis syndrome and may represent a subgroup of this syndrome.
De Silva
D Julian
DJ
Department of Ophthalmology, Chelsea and Westminster Hospital, London, UK.
Obi
Adanna A
AA
Mitchell
Suzanne M
SM
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D007839:Functional Laterality; D005938:Glucocorticoids / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D008218:Lymphocytosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D015864:Panuveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D000998:Antiviral Agents; D005938:Glucocorticoids; D003907:Dexamethasone; D011239:Prednisolone