title: Galaxy: a platform for interactive large-scale genome analysis.
abstract: Accessing and analyzing the exponentially expanding genomic sequence and functional data pose a challenge for biomedical researchers. Here we describe an interactive system, Galaxy, that combines the power of existing genome annotation databases with a simple Web portal to enable users to search remote resources, combine data from independent queries, and visualize the results. The heart of Galaxy is a flexible history system that stores the queries from each user; performs operations such as intersections, unions, and subtractions; and links to other computational tools. Galaxy can be accessed at http://g2.bx.psu.edu.
authors.affiliation: Center for Comparative Genomics and Bioinformatics, Huck Institutes for Life Sciences, Penn State University, University Park, Pennsylvania 16802, USA.
authors.forename: Belinda
authors.initials: B
authors.lastname: Giardine
authors.forename: Cathy
authors.initials: C
authors.lastname: Riemer
authors.forename: Ross C
authors.initials: RC
authors.lastname: Hardison
authors.forename: Richard
authors.initials: R
authors.lastname: Burhans
authors.forename: Laura
authors.initials: L
authors.lastname: Elnitski
authors.forename: Prachi
authors.initials: P
authors.lastname: Shah
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Daniel
authors.initials: D
authors.lastname: Blankenberg
authors.forename: Istvan
authors.initials: I
authors.lastname: Albert
authors.forename: James
authors.initials: J
authors.lastname: Taylor
authors.forename: Webb
authors.initials: W
authors.lastname: Miller
authors.forename: W James
authors.initials: WJ
authors.lastname: Kent
authors.forename: Anton
authors.initials: A
authors.lastname: Nekrutenko
mesh_terms: D005075:Biological Evolution; D030541:Databases, Genetic; D016678:Genome; D020407:Internet; D011401:Promoter Regions, Genetic