Effect of the Chinese traditional medicine "Bushen Yinao Pian" on the cerebral gene expression of the senescence-accelerated mouse prone 8/ta.
The effect of Chinese traditional medicine "Bushen Yinao Pian," a complex prescription used for anti-aging, on the cerebral gene expression of the senescence-accelerated mouse prone 8/Ta (SAMP8/Ta) had been studied with messenger ribonuclear acids reverse transcription differential display polymerase chain reaction (mRNA DDRT-PCR). Eight differential displayed bands had been discerned and sequenced. The sequences of those fragments are matched to adipocyte-specific protein-5; low density lipoprotein receptor-related protein associated protein-1; reticulon-3; cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein-1; cytochrome c oxidase subunit-2 (Cox-2); cytochrome c gene, MC1; DNA sequence from clone RP23-72M11 on chromosome X, respectively and a novel sequence fragment. Most of these genes are aging-related. It can be proved that the "Bushen Yinao Pian" truly has anti-aging function.
Zhang
Chong
C
The Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100080, China.
Wang
Jingang
J
Liu
Guisheng
G
Chen
Qingxuan
Q
D000375:Aging / Q000187:drug effects* / Q000235:genetics; D019588:Aging, Premature / Q000188:drug therapy* / Q000235:genetics; D000818:Animals; D001921:Brain / Q000502:physiology*; D015870:Gene Expression / Q000187:drug effects; D020869:Gene Expression Profiling; D008516:Medicine, Chinese Traditional; D051379:Mice; D008817:Mice, Mutant Strains