Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives.
The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.
Cordova
A
A
Dipartimento di Discipline Chirurgiche ed Oncologiche, Cattedra di Chirurgia Plastica e Ricostruttiva Università di Palermo, Via del Vespro, Palermo, Italy.
Tripoli
M
M
Corradino
B
B
Napoli
P
P
Moschella
F
F
D004387:Dupuytren Contracture / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery*; D004815:Epidermal Growth Factor / Q000502:physiology; D000071938:Fasciotomy; D005353:Fibronectins / Q000502:physiology; D020022:Genetic Predisposition to Disease; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006225:Hand / Q000601:surgery; D006801:Humans; D045726:Metalloproteases / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology
D005353:Fibronectins; D010982:Platelet-Derived Growth Factor; D019714:Tissue Inhibitor of Metalloproteinases; D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D045726:Metalloproteases