Molecular pathogenesis of Hodgkin's lymphoma.
According to the WHO classification, Hodgkin's lymphoma (HL) is subdivided into a classical variant and a nodular lymphocyte predominant variant which are characterized by the presence of Hodgkin's and Reed-Sternberg (H-RS) cells or lymphocytic and histiocytic (L&H) cells, respectively. This article reviews genetic characteristics and transcriptional changes of H-RS and L&H cells, including recent knowledge about transforming mechanisms and signaling pathways that contribute to the antiapoptotic phenotype displayed by H-RS and L&H cells. We also discuss major cellular and molecular mediators contributing to the establishment and maintenance of a reactive background in HL-affected tissues. We believe that an in-depth understanding of the pathogenesis of HL will eventually lead to the development of novel biologically based therapeutic strategies in the near future.
Re
Daniel
D
The Burnham Institute, John Reed Laboratory, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, USA. dre@burnham.org
Küppers
Ralf
R
Diehl
Volker
V
D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006689:Hodgkin Disease / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010641:Phenotype; D011379:Prognosis; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000378:metabolism*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D018121:Receptors, Cytokine; D018124:Receptors, Tumor Necrosis Factor