title: Hepatic lipase polymorphism and increased risk of peripheral arterial disease.
abstract: BACKGROUND
  Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties. We hypothesized single nucleotide polymorphisms in the promoter region of the hepatic lipase gene to be associated with an increased risk for peripheral arterial disease (PAD).
  
  
  METHODS
  A total of 241 patients with PAD and 241 controls matched for sex and age (+/-2 years) were genotyped cross-sectionally for the --250 single nucleotide polymorphism in the hepatic lipase promoter. RESULTS. The frequency for the -250 A allele in patients with PAD was 0.203, whereas it was 0.147 in the controls (P=0.022). Hepatic lipase promoter polymorphism distribution remained significantly different between cases and controls after multivariate logistic regression analysis (P=0.021). The odds ratio of the -250 A hepatic lipase allele for the PAD was 1.69 (95% confidence interval of 1.08-2.64), when adjusted for current smoking, arterial hypertension, cholesterol, triglycerides, HbA(1C), total homocysteine and high sensitivity C-reactive protein.
  
  
  CONCLUSIONS
  Previous data in patients with ischaemic heart disease have suggested a pro-atherogenic role of low hepatic lipase levels. Our results extend these data to the vascular territory of the lower limbs, such that hepatic lipase promoter variation represents a genetic risk factor of PAD.
authors.affiliation: Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Eller
authors.forename: W
authors.initials: W
authors.lastname: Schgoer
authors.forename: T
authors.initials: T
authors.lastname: Mueller
authors.forename: I
authors.initials: I
authors.lastname: Tancevski
authors.forename: A
authors.initials: A
authors.lastname: Wehinger
authors.forename: H
authors.initials: H
authors.lastname: Ulmer
authors.forename: B
authors.initials: B
authors.lastname: Foeger
authors.forename: M
authors.initials: M
authors.lastname: Haltmayer
authors.forename: A
authors.initials: A
authors.lastname: Ritsch
authors.forename: J R
authors.initials: JR
authors.lastname: Patsch
mesh_terms: D000368:Aged; D004812:Epidemiologic Methods; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000201:enzymology / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D005819:Genetic Markers; C504173:LIPC protein, human; D008049:Lipase