title: Mechanotransduction in endothelial cell migration.
abstract: The migration of endothelial cells (ECs) plays an important role in vascular remodeling and regeneration. EC migration can be regulated by different mechanisms such as chemotaxis, haptotaxis, and mechanotaxis. This review will focus on fluid shear stress-induced mechanotransduction during EC migration. EC migration and mechanotransduction can be modulated by cytoskeleton, cell surface receptors such as integrins and proteoglycans, the chemical and physical properties of extracellular matrix (ECM) and cell-cell adhesions. The shear stress applied on the luminal surface of ECs can be sensed by cell membrane and associated receptor and transmitted throughout the cell to cell-ECM adhesions and cell-cell adhesions. As a result, shear stress induces directional migration of ECs by promoting lamellipodial protrusion and the formation of focal adhesions (FAs) at the front in the flow direction and the disassembly of FAs at the rear. Persistent EC migration in the flow direction can be driven by polarized activation of signaling molecules and the positive feedback loops constituted by Rho GTPases, cytoskeleton, and FAs at the leading edge. Furthermore, shear stress-induced EC migration can overcome the haptotaxis of ECs. Given the hemodynamic environment of the vascular system, mechanotransduction during EC migration has a significant impact on vascular development, angiogenesis, and vascular wound healing.
authors.affiliation: Department of Bioengineering and Center for Functional Tissue Engineering, University of California-Berkeley, San Francisco/Berkeley, California 94720, USA. song_li@berkeley.edu
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Ngan F
authors.initials: NF
authors.lastname: Huang
authors.forename: Steven
authors.initials: S
authors.lastname: Hsu
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D003599:Cytoskeleton / Q000201:enzymology / Q000378:metabolism; D042783:Endothelial Cells / Q000201:enzymology / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D022001:Focal Adhesions / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D011509:Proteoglycans / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013314:Stress, Mechanical
chemical_list: D016023:Integrins; D011509:Proteoglycans; D011956:Receptors, Cell Surface