title: Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole or caspofungin prophylaxis.
abstract: Aspergillus ustus is an uncommon clinical species which is poorly susceptible to antifungals. We report two cases of A. ustus infections that occurred in allogeneic stem cell transplant recipients while they were receiving either voriconazole or caspofungin. Prolonged use of these new antifungal agents may increase the risk of the emergence of resistant organisms.
authors.affiliation: Service d'Hématologie-Greffe de Moelle, Hôpital Saint-Louis, Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Pavie
authors.forename: Claire
authors.initials: C
authors.lastname: Lacroix
authors.forename: Dea Garcia
authors.initials: DG
authors.lastname: Hermoso
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.forename: Christèle
authors.initials: C
authors.lastname: Ferry
authors.forename: Anne
authors.initials: A
authors.lastname: Bergeron
authors.forename: Martine
authors.initials: M
authors.lastname: Feuilhade
authors.forename: Françoise
authors.initials: F
authors.lastname: Dromer
authors.forename: Eliane
authors.initials: E
authors.lastname: Gluckman
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Molina
authors.forename: Patricia
authors.initials: P
authors.lastname: Ribaud
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000382:microbiology / Q000517:prevention & control*; D001230:Aspergillus / Q000187:drug effects*; D000077336:Caspofungin; D018890:Chemoprevention; D025141:Drug Resistance, Fungal; D054714:Echinocandins; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D010456:Peptides, Cyclic / Q000494:pharmacology / Q000627:therapeutic use*; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D014184:Transplantation, Homologous / Q000009:adverse effects; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole