Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI.
There have been several researches on the role of personality in the pathophysiology of bipolar disorder. Recently, a polymorphism of XBP1, a pivotal gene in the endoplasmic reticulum (ER) stress response, was shown to contribute to the genetic risk factor for bipolar disorder. Therefore, in this study, we examined the relationship between the XBP1 gene polymorphism and the personality traits assessed by two self-rating scales, a shortened version of Temperament and Character Inventory (TCI) and NEO-Five Factor Inventory (NEO-FFI) in healthy subjects. The present results suggested that the XBP1 gene polymorphism was associated with the NEO-FFI score of neuroticism in female subjects. However, no significant differences in the other personality scale scores of both assessments were observed among normal subjects with -116C/C, C/G and G/G genotypes. Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments.
Kusumi
Ichiro
I
Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060-8638, Japan. ikusumi@med.hokudai.ac.jp
Masui
Takuya
T
Kakiuchi
Chihiro
C
Suzuki
Katsuji
K
Akimoto
Tatsuyuki
T
Hashimoto
Ryota
R
Kunugi
Hiroshi
H
Kato
Tadafumi
T
Koyama
Tsukasa
T
D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D010551:Personality / Q000235:genetics*; D010552:Personality Assessment; D011110:Polymorphism, Genetic; D015995:Prevalence; D040641:Quantitative Trait Loci / Q000235:genetics*; D000071701:Regulatory Factor X Transcription Factors; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic; D011795:Surveys and Questionnaires; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human