Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity.
The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.
Centerwall
Corey R
CR
Department of Chemistry, Syracuse University, CST 1-014, Syracuse, New York 13244-4100, USA.
Goodisman
Jerry
J
Kerwood
Deborah J
DJ
Dabrowiak
James C
JC
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002254:Carbonates / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D015394:Molecular Structure; D012015:Reference Standards; D013997:Time Factors
D000970:Antineoplastic Agents; D002254:Carbonates; D002945:Cisplatin