Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids.
[structures: see text] Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthesized using Stille coupling followed by Mitsunobu cyclization.
Yamaguchi
Seiji
S
Department of Chemistry, Faculty of Science, Toyama University, Gofuku, Toyama 930-8555, Japan. seiji@sci.toyama-u.ac.jp
Tsuchida
Nao
N
Miyazawa
Masahiro
M
Hirai
Yoshiro
Y
D019659:Asteraceae / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis*
D002264:Carboxylic Acids