title: Renal rupture associated with a poorly differentiated follicular thyroid carcinoma metastasizing to the thigh muscle, lung and kidney.
abstract: A 76-year-old woman with a history of total thyroidectomy for a thyroid carcinoma at the age of 63 was admitted to our hospital for the treatment of a renal rupture induced by a tumor of about 3 cm in diameter. High levels of blood thyroglobulin (Tg>1,000 ng/ml) led us to suspect a recurrence of thyroid carcinoma. Strong accumulation in whole-body 123I and 201Tl scintigraphy scans after the nephrectomy revealed tumors in the right lung and left thigh muscle measuring 5 cm and 9 cm in diameter, respectively. The tumors of the kidney and thigh muscle were pathologically diagnosed as poorly differentiated follicular thyroid carcinoma, and the lung tumor was also suggested to be a metastasis of the thyroid carcinoma based on the scintigraphy findings. We report this rare case of follicular thyroid carcinoma associated with metastases to the thigh muscle and kidney leading to a rupture 13 years after a total thyroidectomy. Care should be taken to determine whether unknown tumors are thyroid carcinoma metastases.
authors.affiliation: Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ohno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kiyokawa
authors.forename: Norihiko
authors.initials: N
authors.lastname: Aoki
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000150:complications* / Q000473:pathology / Q000556:secondary; D000368:Aged; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D007680:Kidney Neoplasms / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D019042:Muscle Neoplasms / Q000473:pathology / Q000556:secondary; D012422:Rupture, Spontaneous; D013848:Thigh; D013964:Thyroid Neoplasms / Q000150:complications* / Q000473:pathology; D013997:Time Factors