title: Hematological disorders in Down syndrome: ten-year experience at a Tertiary Care Centre in North India.
abstract: A total of 239 cases of Down syndrome (DS) were seen in the genetic clinic between 1992 and 2003, of which of 15 had hematological manifestations at presentation. These comprised 4 cases of transient myeloproliferative disorder (TMD), 3 cases of TMD/acute leukemia, 4 cases of acute leukemia (AL), 2 of dual deficiency anemia, and 1 case each of myelofibrosis and idiopathic thrombocytopenia. This study emphasizes the fact that an abnormal hemogram in a DS patient does not necessarily indicate AL/TMD, as a considerable number of the cases in this study had other hematological abnormalities. TMD can be differentiated from acute leukemia only on follow-up.
authors.affiliation: Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Anshu
authors.initials: A
authors.lastname: Awasthi
authors.forename: Reena
authors.initials: R
authors.lastname: Das
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.forename: Anju
authors.initials: A
authors.lastname: Gupta
authors.forename: R K
authors.initials: RK
authors.lastname: Marwaha
authors.forename: Gurjeewan
authors.initials: G
authors.lastname: Garewal
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006402:Hematologic Diseases / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007194:India; D007231:Infant, Newborn; D008297:Male