Synthesis of cationic cardiolipin analogues.
An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents.
Kasireddy
Krishnudu
K
Research and Development Facility, NeoPharm, Inc., 1850 Lakeside Drive, Waukegan, IL 60085, USA.
Ali
Shoukath M
SM
Ahmad
Moghis U
MU
Choudhury
Sreeti
S
Chien
Pei-Yu
PY
Sheikh
Saifuddin
S
Ahmad
Imran
I
D002308:Cardiolipins / Q000737:chemistry*; D002412:Cations; D004337:Drug Carriers; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
D002308:Cardiolipins; D002412:Cations; D004337:Drug Carriers; D007202:Indicators and Reagents; D010743:Phospholipids