title: Computational methods for the design of effective therapies against drug resistant HIV strains.
abstract: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.
authors.affiliation: Department of Mathematics, University of California, Berkeley, CA, USA. niko@math.berkeley.edu
authors.forename: Niko
authors.initials: N
authors.lastname: Beerenwinkel
authors.forename: Tobias
authors.initials: T
authors.lastname: Sing
authors.forename: Thomas
authors.initials: T
authors.lastname: Lengauer
authors.forename: Jörg
authors.initials: J
authors.lastname: Rahnenführer
authors.forename: Kirsten
authors.initials: K
authors.lastname: Roomp
authors.forename: Igor
authors.initials: I
authors.lastname: Savenkov
authors.forename: Roman
authors.initials: R
authors.lastname: Fischer
authors.forename: Daniel
authors.initials: D
authors.lastname: Hoffmann
authors.forename: Joachim
authors.initials: J
authors.lastname: Selbig
authors.forename: Klaus
authors.initials: K
authors.lastname: Korn
authors.forename: Hauke
authors.initials: H
authors.lastname: Walter
authors.forename: Thomas
authors.initials: T
authors.lastname: Berg
authors.forename: Patrick
authors.initials: P
authors.lastname: Braun
authors.forename: Gerd
authors.initials: G
authors.lastname: Fätkenheuer
authors.forename: Mark
authors.initials: M
authors.lastname: Oette
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rockstroh
authors.forename: Bernd
authors.initials: B
authors.lastname: Kupfer
authors.forename: Rolf
authors.initials: R
authors.lastname: Kaiser
authors.forename: Martin
authors.initials: M
authors.lastname: Däumer
mesh_terms: D003628:Database Management Systems; D016208:Databases, Factual; D015195:Drug Design; D004346:Drug Information Services; D024882:Drug Resistance, Viral / Q000187:drug effects / Q000235:genetics; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D015316:Genetic Therapy; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000235:genetics*
chemical_list: D014765:Viral Vaccines