Role of B cells in vaccine-induced immunity against coccidioidomycosis.
We investigated secondary immunity against coccidioidomycosis by using gene expression microarrays. Surprisingly, a high percentage of B-cell-related genes were associated with protective immunity. A functional confirmation of the importance of B cells against coccidioidomycosis was achieved by demonstrating that vaccination was not fully protective in B-cell-deficient MuMT mice.
Magee
D Mitchell
DM
Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, 75390-8573, USA. mitch.magee@asu.edu
Friedberg
Rhonda L
RL
Woitaske
Melanie D
MD
Johnston
Stephen Albert
SA
Cox
Rebecca A
RA
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003047:Coccidioidomycosis / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D005657:Fungal Vaccines / Q000276:immunology* / Q000627:therapeutic use; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005803:Genes, Immunoglobulin; D007114:Immunization; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D020411:Oligonucleotide Array Sequence Analysis
D005657:Fungal Vaccines