Modification of gamma ray induced changes in the mouse hepatocytes by Centella asiatica extract: in vivo studies.
Ionizing radiation, besides causing direct damage also generates reactive oxygen species that are capable of inducing damage to various organs. Pretreatment with Centella asiatica 1 h prior to irradiation at a dose rate of 100 mg/kg body weight was found to be effective against radiation induced damage in the liver. The number of normal hepatocytes was higher in the Centella asiatica pretreated group in comparison with the irradiated only group. The number of binucleated cells and abnormal hepatocytes was less in comparison with the animals irradiated without Centella asiatica pretreatment.
Sharma
Radha
R
Department of Zoology, University of Rajasthan, Jaipur 302004, India. Radhasharma13@yahoo.com
Sharma
Jaimala
J
D000818:Animals; D028041:Centella; D005720:Gamma Rays; D022781:Hepatocytes / Q000528:radiation effects; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D010936:Plant Extracts; D011837:Radiation-Protective Agents