title: Rhinovirus illnesses during infancy predict subsequent childhood wheezing.
abstract: BACKGROUND
  The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established.
  
  
  OBJECTIVE
  To evaluate these relationships prospectively from birth to 3 years of age in 285 children genetically at high risk for developing allergic respiratory diseases.
  
  
  METHODS
  By using nasal lavage, the relationship of timing, severity, and etiology of viral respiratory infections during infancy to wheezing in the 3rd year of life was evaluated. In addition, genetic and environmental factors that could modify risk of infections and wheezing prevalence were analyzed.
  
  
  RESULTS
  Risk factors for 3rd year wheezing were passive smoke exposure (odds ratio [OR]=2.1), older siblings (OR=2.5), allergic sensitization to foods at age 1 year (OR=2.0), any moderate to severe respiratory illness without wheezing during infancy (OR=3.6), and at least 1 wheezing illness with respiratory syncytial virus (RSV; OR=3.0), rhinovirus (OR=10) and/or non-rhinovirus/RSV pathogens (OR=3.9) during infancy. When viral etiology was considered, 1st-year wheezing illnesses caused by rhinovirus infection were the strongest predictor of subsequent 3rd year wheezing (OR=6.6; P < .0001). Moreover, 63% of infants who wheezed during rhinovirus seasons continued to wheeze in the 3rd year of life, compared with only 20% of all other infants (OR=6.6; P < .0001).
  
  
  CONCLUSIONS
  In this population of children at increased risk of developing allergies and asthma, the most significant risk factor for the development of preschool childhood wheezing is the occurrence of symptomatic rhinovirus illnesses during infancy that are clinically and prognostically informative based on their seasonal nature.
authors.affiliation: Department of Pediatrics, University of Wisconsin, Madison, WI 53792-9988, USA. rfl@medicine.wisc edu
authors.forename: Robert F
authors.initials: RF
authors.lastname: Lemanske
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Jackson
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gangnon
authors.forename: Michael D
authors.initials: MD
authors.lastname: Evans
authors.forename: Zhanhai
authors.initials: Z
authors.lastname: Li
authors.forename: Peter A
authors.initials: PA
authors.lastname: Shult
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Kirk
authors.forename: Erik
authors.initials: E
authors.lastname: Reisdorf
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Roberg
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Anderson
authors.forename: Kirstin T
authors.initials: KT
authors.lastname: Carlson-Dakes
authors.forename: Kiva J
authors.initials: KJ
authors.lastname: Adler
authors.forename: Stephanie
authors.initials: S
authors.lastname: Gilbertson-White
authors.forename: Tressa E
authors.initials: TE
authors.lastname: Pappas
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Dasilva
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Tisler
authors.forename: James E
authors.initials: JE
authors.lastname: Gern
mesh_terms: D002675:Child, Preschool; D003139:Common Cold / Q000150:complications* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012135:Respiratory Sounds / Q000209:etiology*; D012229:Rhinovirus; D012307:Risk Factors