Mast cells and eosinophils: a novel link between inflammation and angiogenesis in allergic diseases.
Mast cells and eosinophils are the key cells in the early and late stages of allergic inflammation. There is increasing evidence that angiogenesis plays an important role both in the development of inflammation and in the pathophysiology of tissue remodeling during allergic disorders. In this review we provide recent data showing a link between allergy and angiogenesis and some possible mechanisms through which vascular endothelial growth factor and the immune system can interact. We discuss the multifaceted roles of mast cells and eosinophils in tissue remodeling and angiogenesis during allergic diseases and whether these cells can be both source and target cells for pro-angiogenic mediators.
Puxeddu
Ilaria
I
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ribatti
Domenico
D
Crivellato
Enrico
E
Levi-Schaffer
Francesca
F
D000818:Animals; D001249:Asthma / Q000503:physiopathology; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D008168:Lung / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D008407:Mast Cells / Q000276:immunology*; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A
D042461:Vascular Endothelial Growth Factor A