Effects of diazinon on serum calcium and inorganic phosphate levels as well as ultrastructures of parathyroid and calcitonin cells of Rattus norvegicus.
Daily intramuscular administration of two doses--0.50 LD550 (150 mg/kg b w) and 0.75 LD50 (225 mg/kg b w) of diazinon for 14 days induced progressive hypocalcemia without altering serum inorganic phosphate value in Rattus norvegicus. Hypocalcemic response of the pesticide was dose- as well as time-dependent. Parathyroid chief cells of the experimental rats exhibited degranulation, vacuolation, loss of secretory granules and lipid droplets, decreased chromatin, and degenerative changes in endoplasmic reticulum, Golgi complex as well as cristae of the mitochondria. Not much of ultrastructural changes could be seen in the C cells of the rats treated with diazinon.
Rangoonwala
Shaheda P
SP
Department of Zoology, Rizvi College of Arts, Science and Commerce, Off Carter Road, Bandra (West), Mumbai 400 050 India.
Kazim
Malik
M
Pandey
A K
AK
D000818:Animals; D002116:Calcitonin; D002118:Calcium / Q000097:blood; D003976:Diazinon / Q000633:toxicity*; D006996:Hypocalcemia / Q000139:chemically induced*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D010710:Phosphates / Q000097:blood; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000648:ultrastructure
D007306:Insecticides; D010710:Phosphates; D002116:Calcitonin; D002118:Calcium; D003976:Diazinon