title: American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings.
abstract: OBJECTIVE
  To investigate whether American ginseng (AG, Panax quinquefolium) supplementation was able to improve endurance exercise performance.
  
  
  METHODS
  Thirteen physically active male college students were divided into two groups (AG or placebo) and received supplementation for 4 wk, before the exhaustive running exercise. Treadmill speed was increased to a pace equivalent to 80% VO2max of the subject. A 4-wk washout period followed before the subjects crossed over and received the alternate supplement for the next 4 wk. They then completed a second exhaustive running exercise. The physiological variables that were examined included time to exhaustion and oxygen pulse. Moreover, the plasma creatine kinase (CK) and lactate were measured prior to the exercise, at 15 and 30 min during exercise, immediately after exercise, and 20, 40, 60, and 120 min after exercise.
  
  
  RESULTS
  The major finding of this investigation was that the production plasma CK during the exercise significantly decreased for group AG than for group P. Secondary physiological finding was that 80% VO2max running was not improved over a 4-wk AG supplementation regimen.
  
  
  CONCLUSIONS
  Supplementation with AG for 4 wk prior to an exhaustive aerobic treadmill running reduced the leakage of CK during exercise, but did not enhance aerobic work capacity. The reduction of plasma CK may be due to the fact that AG is effective for the decrease of skeletal muscle cell membrane damage, induced by exercise during the high-intensity treadmill run.
authors.affiliation: Graduate Institute of Sports Science, National College of Physical Education and Sports, Taoyuan County, Taiwan, China.
authors.forename: Cheng-Chen
authors.initials: CC
authors.lastname: Hsu
authors.forename: Min-Chen
authors.initials: MC
authors.lastname: Ho
authors.forename: Li-Chin
authors.initials: LC
authors.lastname: Lin
authors.forename: Borcherng
authors.initials: B
authors.lastname: Su
authors.forename: Mei-Chich
authors.initials: MC
authors.lastname: Hsu
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D017079:Exercise Tolerance / Q000187:drug effects*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D005894:Panax; D008517:Phytotherapy
chemical_list: D003402:Creatine Kinase