The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage.
Thrombophilia has been described to be involved in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a C-->T polymorphism at nucleotide 46 in the 5'-untranslated region of the coagulation factor XII (FXII) gene. Two hundred and twelve women with a history of IRM and 149 healthy controls were tested by a mutagenically separated polymerase chain reaction assay (MS PCR). Allele and genotype frequencies were not significantly different between the study and the control groups. Our data suggest that the FXII gene is not a candidate gene for this condition.
Walch
Katharina
K
Department of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria.
Riener
Eva-Katrin
EK
Tempfer
Clemens B
CB
Endler
Georg
G
Huber
Johannes C
JC
Unfried
Gertrud
G
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005174:Factor XII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D010298:Parity; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy
D005174:Factor XII