title: Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.
abstract: The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.
authors.affiliation: Department of Chemistry, University of South Florida, SCA 400, 4202 E. Fowler Avenue, Tampa, Florida, USA. xtal@usf.edu.
authors.forename: Peddy
authors.initials: P
authors.lastname: Vishweshwar
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: McMahon
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Peterson
authors.forename: Magali B
authors.initials: MB
authors.lastname: Hickey
authors.forename: Tanise R
authors.initials: TR
authors.lastname: Shattock
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zaworotko
mesh_terms: D003460:Crystallization; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D018697:Nootropic Agents / Q000138:chemical synthesis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D010889:Piracetam / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D018697:Nootropic Agents; D004364:Pharmaceutical Preparations; D010889:Piracetam