Pemphigus vulgaris triggered by glibenclamide and cilazapril.
A case of pemphigus triggered by glibenclamide and cilazapril is described. The suspicion of drug induction was confirmed in a laboratory study in which a pemphigus-like effect was induced by glibenclamide in cultured human skin explants. Withdrawal of the drugs and their replacement by hydrochlorothiazide and metformin resulted in subsidence of the lesions and no appearance of new lesions. The laboratory study carried out to verify the suspicion of drug induced pemphigus and to confirm the diagnosis proved useful in the differential diagnosis in this case.
Goldberg
Ilan
I
Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Sasson
Aushrat
A
Gat
Andrea
A
Srebrnik
Avigdor
A
Brenner
Sarah
S
D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D017315:Cilazapril / Q000009:adverse effects*; D005905:Glyburide / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D010392:Pemphigus / Q000139:chemically induced*
D000959:Antihypertensive Agents; D007004:Hypoglycemic Agents; D017315:Cilazapril; D005905:Glyburide