title: Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.
abstract: Linkage analyses have identified four major MS susceptibility loci in Finns. Here we have fine mapped the region on chromosome 5p in 28 Finnish MS families. Marker D5S416 provided the highest pairwise LOD score, and multipoint and haplotype analyses restrict the critical region to about 5.3 Mb on 5p15 between markers D5S1987 and D5S416. Ascertaining for HLA type and geographical origin indicated that families with and without the HLA DR15 risk haplotype, as well as families within and outside an internal high-risk region, contributed to the linkage to 5p, implying the general significance for this locus in Finnish MS families.
authors.affiliation: Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
authors.forename: Hilde Monica F
authors.initials: HM
authors.lastname: Riise Stensland
authors.forename: Janna
authors.initials: J
authors.lastname: Saarela
authors.forename: Denis O
authors.initials: DO
authors.lastname: Bronnikov
authors.forename: Maija
authors.initials: M
authors.lastname: Parkkonen
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Jokiaho
authors.forename: Aarno
authors.initials: A
authors.lastname: Palotie
authors.forename: Pentti J
authors.initials: PJ
authors.lastname: Tienari
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Sumelahti
authors.forename: Irina
authors.initials: I
authors.lastname: Elovaara
authors.forename: Keijo
authors.initials: K
authors.lastname: Koivisto
authors.forename: Tuula
authors.initials: T
authors.lastname: Pirttilä
authors.forename: Mauri
authors.initials: M
authors.lastname: Reunanen
authors.forename: Eric
authors.initials: E
authors.lastname: Sobel
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
mesh_terms: D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D005387:Finland; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000235:genetics*
chemical_list: D006684:HLA-DR Antigens