Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment.
Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ventilator-associated lung injury was believed to result from the use of high pressure, thus, the term barotraumas. This trauma is believed to involve free-radical damage. Oxidant injury is a serious cause of lung injury. In the present study, 110 newborns with respiratory distress syndrome were studied; 55 were treated with melatonin and the other 55 with placebo. All the subjects were mechanically ventilated with or without guaranteed volume. Proinflammatory cytokines [interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-alpha] were measured in tracheobronchial aspirate and the clinical outcome was evaluated. Melatonin treatment reduced the proinflammatory cytokines and improved the clinical outcome. The beneficial action of melatonin presumably related to its antioxidative actions.
Gitto
Eloisa
E
Institute of Medical Pediatrics, Neonatal Intensive Care Unit, University of Messina, Messina, Italy.
Reiter
Russel J
RJ
Sabatino
Giuseppe
G
Buonocore
Giuseppe
G
Romeo
Carmelo
C
Gitto
Placido
P
Buggé
Concetta
C
Trimarchi
Giuseppe
G
Barberi
Ignazio
I
D001997:Bronchopulmonary Dysplasia / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000097:blood; D008550:Melatonin / Q000627:therapeutic use*; D010100:Oxygen / Q000378:metabolism; D011175:Positive-Pressure Respiration; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D008550:Melatonin; D010100:Oxygen