Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes.
A series of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes were synthesized from nucleophilic opening of oxirane with different amines. These compounds were evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25microg/ml.
Panda
Gautam
G
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India. gautam_panda@lycos.com
Shagufta
Srivastava
Anil K
AK
Sinha
Sudhir
S
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008697:Methane / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D010616:Phenanthrenes; D008697:Methane