Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects.
This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson.
Quertemont
Etienne
E
Neuroscience Comportementale et Psychopharmacologie, University of Liège, Belgium. equertemont@ulg.ac.be
Eriksson
C J Peter
CJ
Zimatkin
Sergey M
SM
Pronko
Pavel S
PS
Diana
Marco
M
Pisano
Milena
M
Rodd
Zachary A
ZA
Bell
Richard R
RR
Ward
Roberta J
RJ
D000079:Acetaldehyde / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D009042:Motivation; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D011355:Prodrugs / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism
D011355:Prodrugs; D011954:Receptors, Dopamine; D000431:Ethanol; D000079:Acetaldehyde