[Association of polymorphisms in genes of osteoclastogenesis-related cytokines with severity in patients with rheumatoid arthritis].
The development or radiographic progression of rheumatoid arthritis (RA) is associated with HLA-DRB1 alleles encoding a conserved amino acid sequence commonly called the shared epitope(SE). Besides HLA-DRB1, however, other genes may be implicated in the progression of RA. On the other hand, osteoclasts play an important role in the joint destruction in patients with RA. Thus, it is speculated that polymorphisms in genes of cytokines which stimulate or inhibit osteoclastogenesis are associated with severity of RA. In fact, it has been reported that polymorphisms in genes of osteoclastogenesis-related cytokines are associated with the severity or radiographic progression of RA. In this article, we review recent findings, including ours, indicating that polymorphisms in genes of osteoclastogenesis-related cytokines may account for the severity of RA.
Kotake
Shigeru
S
Institute of Rheumatology, Tokyo Women's Medical University.
Kamatani
Naoyuki
N
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002352:Carrier Proteins / Q000235:genetics; D016207:Cytokines / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D010010:Osteoclasts / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics; D053245:RANK Ligand; D011859:Radiography; D053246:Receptor Activator of Nuclear Factor-kappa B; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D002352:Carrier Proteins; D016207:Cytokines; D020381:Interleukin-17; D008562:Membrane Glycoproteins; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C505688:TNFSF11 protein, human; D014409:Tumor Necrosis Factor-alpha