[Study on amplification of ZNF217 in primary gastric carcinoma].
OBJECTIVE
To investigate amplification of zinc finger protein 217(ZNF217) and its association with clinicopathologic parameters in primary gastric carcinoma.


METHODS
Semiquantitative polymerase chain reaction (PCR) was used to determine DNA copies of ZNF217 in the specimens from forty- seven cases with primary gastric carcinoma.


RESULTS
There was no difference in DNA copies between tumor specimens and paratumor normal tissues. The incidence of ZNF217 amplification was 11.36% in gastric cancer. The amplification of ZNF217 was significantly associated with tumor size(P< 0.01) and intestinal type of stomach cancer(P< 0.05).


CONCLUSIONS
Oncogene ZNF217 may play a role in specific tumor types or subtypes of gastric cancer. There may be other oncogenes associated with gastric carcinoma in 20(q)13.
Zhu
Ya-qing
YQ
Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. doctorzhuyq@sina.com
Zhu
Zheng-gang
ZG
Liu
Bing-ya
BY
Chen
Xue-hua
XH
Zhang
Yi
Y
Yin
Hao-ran
HR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*
D004273:DNA, Neoplasm; D015534:Trans-Activators; C113698:ZNF217 protein, human