title: [Candida albicans isolated from buccal cavity of children with Down's syndrome: occurrence and growth inhibition by Streptomyces sp].
abstract: Comparison of the presence of Candida yeasts in the buccal cavity of children without and with Down's syndrome showed a statistically significant difference in the case of children that were affected by this chromosomopathy, rendering them more predisposed to buccal candidiasis, probably due to anatomicophysiologic alterations of the mouth resulting from trisomy of chromosome 21. Constant recurrence of buccal candidiasis in children with this chromosomal alteration lead to the search for a possible therapeutic alternative. Seeking to determine the antifungal activity of Streptomyces sp isolated from various Brazilian soils, 5 strains have been tested for Candida albicans isolated from the buccal cavity of children with Down's syndrome. It was observed that the isolate presented a diversity in the size of the halos (9-31 mm in diameter) of growth inhibition of the yeasts, suggesting a possible use as a therapeutic antifungal.
authors.affiliation: Departamento de Microbiologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO. jvieira@iptsp.ufg.br
authors.forename: José Daniel Gonçalves
authors.initials: JD
authors.lastname: Vieira
authors.forename: Evandro Leão
authors.initials: EL
authors.lastname: Ribeiro
authors.forename: Cerise de Castro
authors.initials: Cde C
authors.lastname: Campos
authors.forename: Fabiana Cristina
authors.initials: FC
authors.lastname: Pimenta
authors.forename: Orlando Ayrton de
authors.initials: OA
authors.lastname: Toledo
authors.forename: Gustavo Morais
authors.initials: GM
authors.lastname: Nagato
authors.forename: Niwmar Alves de
authors.initials: NA
authors.lastname: Souza
authors.forename: Wesley Magno
authors.initials: WM
authors.lastname: Ferreira
authors.forename: Cléver Gomes
authors.initials: CG
authors.lastname: Cardoso
authors.forename: Sueli Meira da Silva
authors.initials: SM
authors.lastname: Dias
authors.forename: César Aparício de
authors.initials: CA
authors.lastname: Araújo Júnior
authors.forename: Daniel Teles
authors.initials: DT
authors.lastname: Zatta
authors.forename: Juliana de Sousa dos
authors.initials: Jde S
authors.lastname: Santos
mesh_terms: D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003140:Communicable Disease Control / Q000379:methods; D004314:Down Syndrome / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012463:Saliva / Q000382:microbiology; D013302:Streptomyces / Q000502:physiology*