Small-cell lung cancer presenting as diabetes insipidus and Cushing's syndrome.
Small-cell lung cancer presenting with a combination of cranial diabetes insipidus and Cushing's syndrome secondary to ectopic adrenocorticotropin (ACTH) secretion is very rare and has only been described previously in one case report Our patient was a 49 year old man, in whom the initial presenting features of small-cell lung cancer were cranial diabetes insipidus secondary to pituitary metastases and severe hypokalaemia resulting from ectopic ACTH hormone secretion. This case is a remarkable example of the complex metabolic endocrine manifestations of small-cell lung cancer.
Agha
Amar
A
Department of Endocrinology, Beaumont Hospital, Dublin, Ireland. amaragha@yahoo.com
Brennan
Sinead
S
Moore
Kevin B
KB
Grogan
Liam
L
Thompson
Christopher J
CJ
D000182:ACTH Syndrome, Ectopic / Q000175:diagnosis; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D003480:Cushing Syndrome / Q000175:diagnosis*; D003919:Diabetes Insipidus / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged