title: Non-steroidal anti-inflammatory drug (NSAID)-induced colonic strictures and perforation: a case report.
abstract: Although non-steroidal anti-inflammatory drug-induced colopathy is well described, colonic perforations complicating non-steroidal anti-inflammatory drug intake are rare. We report a patient with rheumatoid arthritis who was on long-term diclofenac and presented with early colonic stricture formation and a caecal perforation, which to the best of our knowledge, has only been reported once before. It is important to suspect this diagnosis in patients on non-steroidal anti-inflammatory drug therapy who present with an acute abdomen.
authors.affiliation: Section of Surgery, Division of Gastrointestinal Surgery, University Hospital, Queen's Medical Centre, E Floor West Block, Nottingham NG7 2UH, UK.
authors.forename: M M
authors.initials: MM
authors.lastname: Aloysius
authors.forename: P V
authors.initials: PV
authors.lastname: Kaye
authors.forename: D N
authors.initials: DN
authors.lastname: Lobo
mesh_terms: D000006:Abdomen, Acute / Q000139:chemically induced; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003106:Colon / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D003108:Colonic Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal