Loss of apoptosis-inducing factor leads to an increase in reactive oxygen species, and an impairment of respiration that can be reversed by antioxidants.
Apostolova
N
N
Cervera
A M
AM
Victor
V M
VM
Cadenas
S
S
Sanjuan-Pla
A
A
Alvarez-Barrientos
A
A
Esplugues
J V
JV
McCreath
K J
KJ
D000975:Antioxidants / Q000494:pharmacology*; D051033:Apoptosis Inducing Factor / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D045744:Cell Line, Tumor; D019069:Cell Respiration / Q000187:drug effects / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D020868:Gene Silencing; D005822:Genetic Vectors; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D034741:RNA, Small Interfering / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D051033:Apoptosis Inducing Factor; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D034741:RNA, Small Interfering; D017382:Reactive Oxygen Species; D013481:Superoxides