Clinical and laboratory characteristics of drug-induced vasculitic syndromes.
Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage). Withdrawal of the drug often leads to spontaneous recovery, meaning that immunosuppressive therapy can be avoided. The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol. Clinically, skin vasculitis and arthralgias predominated and renal vasculitis was rare.
Wiik
Allan
A
Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark. aw@ssi.dk
D058186:Acute Kidney Injury / Q000209:etiology; D017153:Antibodies, Anticardiolipin / Q000097:blood; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D013956:Antithyroid Agents / Q000009:adverse effects; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D015267:Churg-Strauss Syndrome / Q000175:diagnosis; D003937:Diagnosis, Differential; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007668:Kidney / Q000098:blood supply; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000175:diagnosis; D008713:Methimazole / Q000009:adverse effects; D011441:Propylthiouracil / Q000009:adverse effects; D012867:Skin / Q000098:blood supply; D019851:Thrombophilia / Q000209:etiology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000097:blood / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000276:immunology
D017153:Antibodies, Anticardiolipin; D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D001323:Autoantibodies; D007075:Immunoglobulin M; D008713:Methimazole; D011441:Propylthiouracil