title: Endodermal sinus tumor of the vagina.
abstract: Malignant germ cell tumors of the vagina represent a critical site for local treatment. We report on our experience with two vaginal endodermal sinus tumors. Treatment with PEB regimen induced both tumor regression and alpha fetoprotein normalization. One patient had a residual lesion that was biopsied twice and no viable tumor cells were ever found. Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors.
authors.affiliation: Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy. monica.terenziani@istitutotumori.mi.it
authors.forename: Monica
authors.initials: M
authors.lastname: Terenziani
authors.forename: Filippo
authors.initials: F
authors.lastname: Spreafico
authors.forename: Paola
authors.initials: P
authors.lastname: Collini
authors.forename: Cristina
authors.initials: C
authors.lastname: Meazza
authors.forename: Maura
authors.initials: M
authors.lastname: Massimino
authors.forename: Luigi
authors.initials: L
authors.lastname: Piva
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D018240:Endodermal Sinus Tumor / Q000188:drug therapy*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D012074:Remission Induction; D014625:Vaginal Neoplasms / Q000188:drug therapy*
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin