Susceptibility of Chinese rhesus monkeys to SIV infection.
The use of China-derived monkeys in AIDS research has been limited by reports of reduced susceptibility to SIV. We performed a serial passage of SIV in Chinese macaques, which resulted in a viral stock capable of inducing simian AIDS and high levels of replication in these animals. Similar to HIV in humans, SIV pathogenesis in non-human primates is not limited by geographical origin. Chinese macaques are useful in pathogenesis, vaccine, and therapeutic studies in AIDS.
Burdo
Tricia H
TH
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Marcondes
Maria Cecilia G
MC
Lanigan
Caroline M S
CM
Penedo
Maria Cecilia T
MC
Fox
Howard S
HS
D000818:Animals; D016516:CD4-CD8 Ratio; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity* / Q000502:physiology; D019562:Viral Load; D014774:Virulence; D014779:Virus Replication