Scheme-based benzodiazepine detoxification with oxcarbazepine -- a case report.
We attempted to evaluate the tolerability and efficacy of the antiepileptic drug oxcarbazepine in benzodiazepine detoxification, by observing several cases. Detoxification followed a predefined dosage scheme. All patients detoxified with oxcarbazepine completed the withdrawal successfully, without withdrawal symptoms. The administration of oxcarbazepine according to the scheme proved to be tolerable. The dosage was sufficient. Though uncontrolled case observations must be interpreted with caution, oxcarbazepine appears to be a promising drug in inpatient benzodiazepine withdrawal. It should be examined in further randomized placebo-controlled studies including long-term follow-ups.
Croissant
B
B
Grosshans
M
M
Klein
O
O
Diehl
A
A
Mann
K
K
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D000078330:Oxcarbazepine; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D000927:Anticonvulsants; D001569:Benzodiazepines; D002220:Carbamazepine; D000078330:Oxcarbazepine