Anterior mediastinal immature teratoma with precocious puberty in a child with Klinefelter syndrome.
Klinefelter syndrome occurs in approximately 1 in 1000 males. A 4-year-old boy presented with precocious puberty and an anterior mediastinal mass. Serum alpha-fetoprotein and human chorionic gonadotropin levels were mildly increased. Computed tomography revealed a germ cell tumor (GCT) of the mediastinum. Complete resection of the tumor was performed. Histologic analysis revealed an immature teratoma. Males with Klinefelter syndrome develop GCTs at a rate 50 times higher than unaffected males. This case report calls attention to the need to rule out Klinefelter syndrome in boys who present with precocious puberty and a mediastinal GCT.
Su
Pen-Hua
PH
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Luh
Shi-Ping
SP
Yieh
Da-Mien
DM
Chen
Jia-Yuh
JY
Chen
Suh-Jen
SJ
Hung
Huei-Mei
HM
Liao
Pei-Fen
PF
D002675:Child, Preschool; D018237:Germinoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D011629:Puberty, Precocious / Q000209:etiology*; D011859:Radiography