[The influence of calcium folinate on the immunotoxicity of methanol].
The experiments on non-inbred rats showed that calcium folinate administered upon acute poisoning (0.5LD50) with methanol partly reduced the degree of suppression of the phagocyte metabolic activity of polymorphonuclear leukocytes, the T-dependent humoral immune response, the activity of natural killers, the antibody-dependent cell-mediated cytotoxicity, and the formation of the delay-type hypersensitivity, and completely restores the function of B-cells estimated using the T-independent antibody production.
Zabrodskiĭ
P F
PF
Lim
V G
VG
Troshkin
N M
NM
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006967:Hypersensitivity / Q000276:immunology; D007109:Immunity / Q000187:drug effects* / Q000276:immunology; D002955:Leucovorin / Q000008:administration & dosage*; D008297:Male; D000432:Methanol / Q000506:poisoning*; D010586:Phagocytes / Q000276:immunology; D051381:Rats; D012997:Solvents / Q000506:poisoning*; D013601:T-Lymphocytes / Q000276:immunology
D012997:Solvents; D002955:Leucovorin; D000432:Methanol