title: Enantioselective direct aldol-Tishchenko reaction: access to chiral stereopentads.
abstract: [reaction: see text] The aldol-Tishchenko reaction of aromatic aldehydes in the presence of titanium(IV) tertbutoxide and amino alcohols is described. When used with cinchona alkaloids, stereopentads were isolated for the first time with a high degree of diastereo- and enantioselectivity.
authors.affiliation: Humboldt-Universität zu Berlin, Chemisches Institut, Brook-Taylor Str. 2, 12489 Berlin, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Rohr
authors.forename: Robert
authors.initials: R
authors.lastname: Herre
authors.forename: Rainer
authors.initials: R
authors.lastname: Mahrwald
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry; D000605:Amino Alcohols / Q000737:chemistry; D008958:Models, Molecular; D010420:Pentanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000470:Alkaloids; D000605:Amino Alcohols; D010420:Pentanes; C033353:pentane; C116609:3-hydroxybutanal