title: Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia.
abstract: This study investigated the neuroprotective effects of cyanidin-3-O-beta-d-glucopyranoside (C3G) from the mulberry fruits on neuronal cell damage. A 1% HCl-MeOH mulberry fruit extract was shown to have a cytoprotective effect on PC12 cells that had been exposed to hydrogen peroxide. The extract inhibited the cerebral ischemic damage caused by oxygen glucose deprivation (OGD) in PC12 cells. The neuroprotective effect of the mulberry fruit extract was further demonstrated in vivo using a mouse-brain-injury model with a transient middle cerebral artery occlusion (MCAO). C3G was isolated as a neuroprotective constituent from the mulberry fruit extract. Compared with the control group, C3G had neuroprotective effects on the PC12 cells exposed to hydrogen peroxide in vitro and on cerebral ischemic damage in vivo.
authors.affiliation: Graduate School of East-West Medical Science, Kyunghee University, Kyunggi 449-701, South Korea.
authors.forename: Tong Ho
authors.initials: TH
authors.lastname: Kang
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Hur
authors.forename: Hyun Bok
authors.initials: HB
authors.lastname: Kim
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ryu
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D002545:Brain Ischemia / Q000473:pathology* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D031625:Morus / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D016716:PC12 Cells; D010936:Plant Extracts / Q000008:administration & dosage; D051381:Rats
chemical_list: D000872:Anthocyanins; D018696:Neuroprotective Agents; D010936:Plant Extracts; C462279:cyanidin-3-O-beta-glucopyranoside