title: [Sleep and circadian rhythms in ageing].
abstract: With age, the consolidation of nocturnal sleep decreases, daytime napping increases, and sleep occurs earlier. Sleep regulation is dependent on the interaction between a circadian pacemaker (biological clock) and the sleep homeostat (sleep pressure increasing with duration of time awake). We have shown that in the healthy elderly, the amplitude of circadian rhythms (e. g. melatonin secretion) declines, as does slow wave sleep, parallel with an increase in afternoon sleepiness and a tendency to fall asleep in the early evening when younger subjects do not. Light is the major zeitgeber to stabilise the biological clock: older subjects require sufficient light exposure during daytime and in the evening, and should take no or only brief naps during the day to improve sleep.
authors.affiliation: Zentrum der Chronobiologie, Universitäre Psychiatrische Kliniken, Wilhelm-Klein-Strasse 27, 4025, Basel, Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Münch
authors.forename: C
authors.initials: C
authors.lastname: Cajochen
authors.forename: A
authors.initials: A
authors.lastname: Wirz-Justice
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D008027:Light; D008550:Melatonin / Q000378:metabolism*; D010775:Photic Stimulation / Q000379:methods; D012890:Sleep / Q000502:physiology* / Q000528:radiation effects; D020178:Sleep Disorders, Circadian Rhythm / Q000503:physiopathology* / Q000517:prevention & control*
chemical_list: D008550:Melatonin