Myelodysplastic syndromes: clinicopathologic features, pathobiology, and molecular pathogenesis.
BACKGROUND
Myelodysplastic syndromes (MDSs) are clonal stem cell diseases characterized by ineffective hematopoiesis, multilineage dysplasia, and peripheral cytopenias with normocellular or hypercellular marrow. They represent a heterogeneous group of disorders with a varied spectrum of clinical, morphologic, biologic, and genetic characteristics. This heterogeneity in disease characterization has led to evolving classification systems, developing prognostic models, and continuing research efforts to elucidate its pathobiology and pathogenesis.


OBJECTIVE
To summarize updated information and provide a general overview of the clinicopathologic features, pathobiology, and cytogenetic and molecular pathogenesis of MDSs.


METHODS
Relevant articles indexed in PubMed (National Library of Medicine) between 1982 and 2005 and reference medical texts.


CONCLUSIONS
Although MDSs remain a relatively poorly defined disease entity, recent advancements in cytogenetic and molecular studies have significantly contributed to our present knowledge of MDSs. Novel strategies for studying the pathogenesis and evolution of MDSs continue to shape our understanding of this disease and guide our approaches to diagnosis and treatment.
Nishino
Ha Thanh
HT
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA.
Chang
Chung-Che
CC
D003582:Cytogenetics; D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis
D004247:DNA