Iron overload and chelation.
Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form is extremely low. Hence, living organisms were compelled to develop efficient mechanisms for iron transport and storage.
Hershko
Chaim
C
Department of Hematology, Shaare Zedek Medical Center, Israel. hershko@szmc.org.il
Link
Gabriela
G
Konijn
Abraham M
AM
Ioav Cabantchik
Z
Z
D015913:Chelation Therapy / Q000379:methods*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000209:etiology / Q000628:therapy*; D017262:Siderophores / Q000627:therapeutic use; D016896:Treatment Outcome
D007502:Iron Chelating Agents; D017262:Siderophores