[Pathologic diagnosis of endometrial carcinoma in curettage specimens in women under forty years of age].
OBJECTIVE
To investigate the diagnostic pathological features of endometrial carcinomas present in women under 40 years of age (by curettage samples).


METHODS
A retrospective analysis was performed on 20 cases of endometrial carcinomas in women under 40 years of age.


RESULTS
The patients included 18 endometrioid adenocarcinoma cases, one adenosquamous carcinoma case, and one papillary serous carcinoma case. The morphological features of the endometrial adenocarcinoaare loss of polarity (orientation) of the endometrial glands. The tumor cells have large round vesicular nuclei, prominent nucleoli and coarse chromatin. In addition, endometrial stroma was instead of by the fibrous and/or granulation tissue type stroma, usually with inflammatory response. Majority cases of endometrioid adenocarcinomas had superficial invasion of myometrium and no lymph node metastasis. The adenosquamous case metastasized to the ovaries and the papillary serous carcinoma case metastasized to the pelvic lymph nodes.


CONCLUSIONS
Endometrial carcinomas which are highly differentiated endometrioid adenocarcinomas occur frequently in women under 40 years of age. An important differential diagnosis of the endometrioid carcinoma in a curettage specimen is to differentiate it from atypical endometrial hyperplasia and atypical polypoid adenomyoma.
Wang
Mei-qing
MQ
Department of Pathology, Qilu Medical College of Shandong University, Jinan 250012, China.
Zhang
Qing-hui
QH
Guo
Ling-ling
LL
Cai
Yi-ran
YR
Wang
Yan
Y
D018194:Adenomyoma / Q000473:pathology; D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000556:secondary; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000473:pathology; D003937:Diagnosis, Differential; D004107:Dilatation and Curettage; D004714:Endometrial Hyperplasia / Q000473:pathology; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009215:Myometrium / Q000473:pathology; D010051:Ovarian Neoplasms / Q000556:secondary; D010388:Pelvis; D012189:Retrospective Studies