title: The role of collagen in bone structure: an image processing approach.
abstract: Bone collagen structure in normal and pathological tissues is illustrated using techniques of thin section transmission electron microscopy and computer-assisted analysis. The normal bone collagen types, fibril architecture and diameter are described. In pathological tissue, deviations from normal fine structure are reflected in abnormal arrangements of collagen fibrils and abnormalities in fibril diameter. Computer analyses of normal fibril positive staining patterns are presented in order to provide a basis for comparing such patterns with pathological ones.
authors.affiliation: Laboratory of Medical Physics, Medical School, Ioannina University, P.O. Box 1186, 45110 Ioannina, Greece. mtzaphli@cc.uoi.gr
authors.forename: Margaret
authors.initials: M
authors.lastname: Tzaphlidou
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000503:physiopathology; D001842:Bone and Bones / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis / Q000502:physiology* / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D046529:Microscopy, Electron, Transmission; D010024:Osteoporosis / Q000473:pathology / Q000503:physiopathology; D013977:Tibia / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure
chemical_list: D003094:Collagen