[Craniopharyngiomas in the adults].
Craniopharyngiomas (CP) were studied morphologically (52 cases), immunohistochemically (6 cases) and molecular-genetically (5 cases) in patients aged 18-65 years. Main causes of death early after surgery are disturbances in the hypothalamic region connected with surgical intervention. The highest lethality is observed after removal of extra-intraventricular neoplasms (44.4%). Lethality increases in patients with repeated surgery. Early postoperative lethality is much lower in the group of papillomatous CP. These tumors well expressed pancytokeratins, cytokeratin 14 and MUC-1, particularly in foci of pronounced keratinization. Oncoproteins c-kit and c-erbB-2 as well as estrogen and progesteron receptors were not observed. Proliferative activity (Ki-67) in CP is 11% in adamantinomatous CP and 2% in capillary CP and pronounced proliferation is observed around keratohyalin deposits. Accumulation of micromutations produced by the inactivation of genes "mismatch DNA reparation" is not typical for CP.
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D003397:Craniopharyngioma / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality*
D014408:Biomarkers, Tumor