title: [An epidemiological investigation on gastroschisis in China during 1996 to 2000].
abstract: OBJECTIVE
  To study the epidemiological characteristics of gastroschisis in China from 1996 to 2000.
  
  
  METHODS
  The birth defects monitoring program was undertaken in 450-466 hospitals from 31 provinces, cities and autonomous regions of China. Data about births including intrauterine death and stillbirth of 28 weeks of gestation was collected to report through the medical records over the time period 1996 to 2000. The maximal diagnosis time was up to 1 week after the delivery. The international Classification of Diseases of Ninth Revision with some modifications was used to code the birth defects.
  
  
  RESULTS
  A total of 569 cases with gastroschisis was found in 2,218,616 births monitored. The overall birth incidence of gastroschisis was 2.56 per 10,000 births during the monitored period. The increasing trend of incidence of gastroschisis hadn't been found (P > 0.05). The birth incidence of gastroschisis in rural areas was significant higher than that in urban areas (3.93 vs.1.98 per 10,000, P < 0.01). There was also significantly difference on birth incidence between female and male (2.64 vs. 2.15 per 10,000 births, P < 0.05). The birth incidence of gastroschisis in the mothers less than 20 years old was the highest among all mothers age, which were at 5.4 times increased risk relative to that of mother age of 25-29 years old. The overall perinatal mortality rate of gastroschisis was 74.69 percent, and 41.46 percent of gastroschisis were diagnosed before birth. 27.44 percent of cases were accompanied with other major defects.
  
  
  CONCLUSIONS
  There was no increasing trend on the incidence of gastroschisis to be found in China during 1996 to 2000. The mother age less than 20 years old was at an increasing risk of fetal gastroschisis. The cases with gastroschisis had a high perinatal mortality rate.
authors.affiliation: National Office for Maternal and Child Health Surveillance, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Guang-xuan
authors.initials: GX
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Dai
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Liang
authors.forename: Lei
authors.initials: L
authors.lastname: Miao
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology*; D020139:Gastroschisis / Q000453:epidemiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012307:Risk Factors; D012737:Sex Factors; D055815:Young Adult