title: First synthesis of beta-keto sulfoxides by a palladium-catalyzed carbonylative Suzuki reaction.
abstract: [reaction: see text] An unprecedented palladium-catalyzed three-component cross-coupling reaction between alpha-bromo sulfoxide, carbon monoxide, and aromatic boronic acids provides a new and efficient approach to the synthesis of beta-ketosulfoxides. The reaction takes place under mild conditions with a wide range of variously substituted aryl and heteroaryl boronic acids. The carbonylative cross-coupling reaction is strongly favored over competing direct cross-coupling and homocoupling processes, except with boronic acids carrying strong electron-withdrawing substituents.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, Avda Vicent Andres Estelles s/n, 46100 Burjassot, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Medio-Simón
authors.forename: Cristian
authors.initials: C
authors.lastname: Mollar
authors.forename: Nuria
authors.initials: N
authors.lastname: Rodríguez
authors.forename: Gregorio
authors.initials: G
authors.lastname: Asensio