title: [Alflutop in local therapy of shoulder periarthritis].
abstract: OBJECTIVE
  To study efficacy of a compound biological preparation alflutop in local therapy of shoulder periarthritis (SP), to compare its efficacy with that of periarticular diprospan.
  
  
  METHODS
  The trial included 54 patients with SP. Clinical SP forms consisted of subacromial and subdeltoid bursitis (SSB) (42.6%), tendinitis (57.4%). Acute disease was diagnosed in 35.2% patients, chronic one--in 64.8%. Alflutop and diprospan were injected periarticularly. The patients were divided into three groups. Patients of group 1 (n = 15) received alflutop monotherapy (2 ml, 5 injections). Group 2 (n = 24) received a single injection of diprospan (7 mg). Group 3 (n = 15) patients were given combined treatment: a single injection (7 mg) of diprospan followed by alflutop infiltrations (2 mg, 5 injections). The efficacy of the treatment was judged by some score clinical parameters, dynamometrical findings, SDQ score set, thermographic and ultrasonic signs of periarticular inflammation.
  
  
  RESULTS
  A course of periarticular alflutop infiltrations in SP demonstrated the same efficacy as a single dose diprospan. However, in acute SP with bursitis diprospan produced a significantly better results while alflutop was better in chronic SP with tendinitis. Diprospan combination with alflutop produced the highest therapeutic effect irrespective of the disease course and clinical SP course.
  
  
  CONCLUSIONS
  Local administration of alflutop in SP as monotherapy alternative to glucocorticosteroids or in combination with diprospan is effective. A differentiated approach allowing for a clinical form and course of SP raises therapeutic efficacy noticeably.
authors.forename: S M
authors.initials: SM
authors.lastname: Noskov
authors.forename: O I
authors.initials: OI
authors.lastname: Fetelego
authors.forename: I G
authors.initials: IG
authors.lastname: Krasivina
authors.forename: L N
authors.initials: LN
authors.lastname: Dolgova
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001623:Betamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010489:Periarthritis / Q000188:drug therapy* / Q000503:physiopathology*; D012782:Shoulder
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; C032812:betamethasone dipropionate, betamethasone sodium phosphate drug combination; D001623:Betamethasone