Convenient access to glutamic acid side chain homologues compatible with solid phase peptide synthesis.
[reaction: see text] Preparation of several side chain length variants of glutamic acid is achieved via olefin cross metathesis of allyl glycine derivatives. The products are suitably protected for direct use in Fmoc solid-phase peptide synthesis, as demonstrated by successful synthesis of test sequences.
Ryan
Shannon J
SJ
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Zhang
Yongda
Y
Kennan
Alan J
AJ
D000475:Alkenes / Q000737:chemistry; D000501:Allylglycine / Q000737:chemistry; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D018698:Glutamic Acid / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D010455:Peptides; D000501:Allylglycine; D018698:Glutamic Acid