title: Effects of a free radical scavenger, MCI-186, on ischemia-reperfusion injury during extended liver resection in dogs.
abstract: OBJECTIVE
  In liver surgery, total clamping of the portal triad (Pringle's procedure) is commonly used, and this sometimes causes liver failure. This study evaluated the effects of a free radical scavenger, MCI-186, on ischemia-reperfusion injury during liver resection in dogs.
  
  
  METHODS
  The experimental animals were divided into two groups. In the MCI group (n = 6), MCI-186 (6mg/kg/h) was administered twice, through a catheter placed in the right hepatic vein: the first time was from 0.5 hours before the onset of ischemia until ischemia by partial inflow occlusion, and the second was from 0.5-hours before reperfusion until reperfusion. In the control group (n = 6), vehicle (physiological saline) was administered in the same manner.
  
  
  RESULTS
  The serum AST, ALT, and LDH levels were significantly (P < 0.05) lower in the MCI group than in the control group. Hepatic tissue blood flow 0.5 hours after reperfusion was significantly (P < 0.05) higher in the MCI group than in the control group. Histological tissue damage was mild, and tissue MDA levels were significantly (P < 0.05) lower in the MCI group than in the control group.
  
  
  CONCLUSIONS
  MCI-186 ameliorates the ischemia-reperfusion injury caused by Pringle's procedure during extended liver resection.
authors.affiliation: Second Department of Surgery, Gunma University School of Medicine, Gunma, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Totsuka
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Arakawa
authors.forename: Takahiko
authors.initials: T
authors.lastname: Akao
authors.forename: Masato
authors.initials: M
authors.lastname: Muraoka
authors.forename: Susumu
authors.initials: S
authors.lastname: Ohwada
authors.forename: Koshi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishita
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004285:Dogs; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006498:Hepatectomy; D015227:Lipid Peroxidation; D008099:Liver / Q000098:blood supply; D008833:Microcirculation; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine