Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica.
The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.
Diderot
Noungoue Tchamo
NT
Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon.
Silvere
Ngouela
N
Yasin
Amsha
A
Zareen
Seema
S
Fabien
Zelefack
Z
Etienne
Tsamo
T
Choudhary
M Iqbal
MI
Atta-Ur-Rahman
D000818:Animals; D029061:Annonaceae / Q000201:enzymology*; D000925:Anticoagulants / Q000737:chemistry / Q000627:therapeutic use*; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000627:therapeutic use*; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D004224:Diterpenes; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D013917:Thrombin