Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function.
Smooth muscles from the urethra and bladder display characteristic patterns of spontaneous contractile activity in the filling phase of the micturition cycle. Tonic contractions are seen in the urethral smooth muscles, and phasic contractions occur in the detrusor. Overactivity in the detrusor is a common clinical problem. The ion channels in the smooth muscle membranes play an important role in determining the functional properties, and are obvious targets for treatment of the overactive bladder. Recent evidence suggests that interstitial cells may also play a role in determining the pattern of spontaneous activity, although their precise role is less well established in the urinary tract than in the gut. The ion channels involved in these cells are also of interest. This review discusses what is known of ion channels in these tissues, and their implications for function.
Brading
A F
AF
Oxford Continence Group, University Department of Pharmacology, Mansfield Road, Oxford OX1 3QT, UK. alison.brading@pharm.ox.ac.uk
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000166:cytology / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D014521:Urethra / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism; D014551:Urinary Tract / Q000166:cytology / Q000378:metabolism*
D015220:Calcium Channels; D007473:Ion Channels; D015221:Potassium Channels