Natural history of familial myomas.
OBJECTIVE
To study the natural history of myomas in familial cases and to compare the tendencies of myomas between familial and non-familial cases.


METHODS
Subjects with familial and non-familial myomas were identified from the hospital records and the reliable details of the myomas were collected.


RESULTS
In the familial cases there are several myomas, four or more. In the non-familial cases, there is usually only one single myoma, which is bigger than in familial cases. In the familial group, the diagnosis and surgery was made earlier. In the familial group, there were more pregnancies and less infertility problems.


CONCLUSIONS
There is a significant difference in the natural history of the familial and non-familial cases. In familial cases, subjects have four or more myomas while in non-familial cases the fibroid is single and large.
Uimari
Outi
O
Department of Obstetrics and Gynecology, Oulu University Hospital, PL 24, 90029 OYS Oulu, Finland.
Suomalainen-König
Sanna
S
Sakkinen
Nina
N
Santala
Markku
M
Nieminen
Pentti
P
Ryynanen
Markku
M
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005192:Family Health; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology