Clinical and histopathological findings in Bannayan-Riley-Ruvalcaba syndrome.
Bannayan-Riley-Ruvalcaba syndrome is a rare autosomal dominant genodermatosis with the classical triad of macrocephaly, genital lentiginosis, and intestinal polyposis. Characteristic mucocutaneous manifestations include vascular malformations, lipomatosis, speckled lentiginosis of the penis or vulva, facial verrucae-like or acanthosis nigricans-like lesions, and multiple acrochordons of the neck, axilla, and groin. We present a case of Bannayan-Riley-Ruvalcaba syndrome with macrocephaly, abnormal facies, lipoma, tender and painful arteriovenous hemangiomas, lymphangiokeratomas, musculoskeletal abnormalities, and localized myopathy. We also describe previously unreported findings, including peripheral neuropathy, punctate cystic changes in acral tubular bones, and enostosis of talus. Bannayan-Riley-Ruvalcaba syndrome needs recognition by dermatologists because affected patients may present with mucocutaneous and subcutaneous lesions that may simulate other dermatological disorders.
Erkek
Emel
E
Department of Dermatology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey. emelerkek@hotmail.com
Hizel
Selda
S
Sanlý
Cihat
C
Erkek
A Bulent
AB
Tombakoglu
Meryem
M
Bozdogan
Onder
O
Ulkatan
Sedat
S
Akarsu
Cengiz
C
D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology; D011125:Adenomatous Polyposis Coli / Q000601:surgery; D002648:Child; D020405:Dermis / Q000473:pathology; D018095:Germ-Line Mutation; D006257:Head / Q000002:abnormalities*; D006391:Hemangioma / Q000473:pathology; D006801:Humans; D007642:Keratosis / Q000473:pathology; D007911:Lentigo / Q000473:pathology; D008297:Male; D051059:PTEN Phosphohydrolase / Q000235:genetics; D010409:Penile Diseases / Q000473:pathology; D013577:Syndrome; D014860:Warts / Q000473:pathology
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human