Post-exposure administration of edaravone attenuates noise-induced hearing loss.
We investigated the effects of the antioxidant edaravone against acoustic trauma in guinea pigs. Edaravone (1.722 x 10(-2) M) was infused into the right ear by an osmotic pump, and the left ear was untreated for control. Animals received edaravone 9 h before (-9 h group, n = 7) and 9 h (+9 h group, n = 8), 21 h (+21 h group, n = 7) and 33 h (+33 h group, n = 4) after 3-h exposure to 130-dB noise. Seven days after noise exposure, we examined the shift in auditory brainstem response thresholds and histopathologic characteristics of the sensory epithelia. The smallest shift in auditory brainstem response threshold and smallest proportion of missing outer hair cells were observed in the +9 h group. This result was supported by immunohistochemical analysis of 4-hydroxy-2-nonenal. Our data suggest that edaravone may be clinically effective in the treatment of acoustic trauma, especially if given within 21 h of noise exposure.
Tanaka
Kuniyoshi
K
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan.
Takemoto
Tsuyoshi
T
Sugahara
Kazuma
K
Okuda
Takeshi
T
Mikuriya
Takefumi
T
Takeno
Kenji
K
Hashimoto
Makoto
M
Shimogori
Hiroaki
H
Yamashita
Hiroshi
H
D000447:Aldehydes / Q000032:analysis; D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001309:Auditory Threshold / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects / Q000503:physiopathology; D002452:Cell Count; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000473:pathology; D034381:Hearing Loss / Q000209:etiology / Q000517:prevention & control*; D007150:Immunohistochemistry; D008297:Male; D009622:Noise / Q000009:adverse effects*; D009925:Organ of Corti / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008517:Phytotherapy
D000447:Aldehydes; D016166:Free Radical Scavengers; C027576:4-hydroxy-2-nonenal; D000077553:Edaravone; D000983:Antipyrine