title: [The composition and drug sensitivity of a mycobacterial population in patients with suspected tuberculosis].
abstract: By using the diagnostic material (175 sputum samples and 103 bronchoalveolar lavage fluid samples) taken from 39 patients with suspected tuberculous infection during a 2.5-month follow-up, the authors traced the time course of changes in the composition and drug sensitivity of a mycobacterial population to rifampicin. Along with the traditional microbiological studies, the latest molecular biological studies, a TB-BIOCHIP test system (enzyme immunoassay) in particular, were employed to detect the bacterial and L-transformed forms of the causative agent. A molecular biological assay was first developed to detect the drug sensitivity of L-forms of Mycobacterium tuberculosis.
authors.forename: I R
authors.initials: IR
authors.lastname: Dorozhkova
authors.forename: M V
authors.initials: MV
authors.lastname: Badleeva
authors.forename: O I
authors.initials: OI
authors.lastname: Skotnikova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Nosova
authors.forename: E A
authors.initials: EA
authors.lastname: Kupavtseva
authors.forename: S E
authors.initials: SE
authors.lastname: Borisov
authors.forename: A M
authors.initials: AM
authors.lastname: Moroz
mesh_terms: D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid; D016009:Chi-Square Distribution; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007740:L Forms / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification*; D012293:Rifampin / Q000494:pharmacology*; D013183:Sputum / Q000382:microbiology; D013997:Time Factors
chemical_list: D000904:Antibiotics, Antitubercular; D012293:Rifampin