[Effect of low dose irradiation on the reaction of blood lymphocytes of individuals with the somatic diseases].
The reaction of blood lymphocytes on adaptive irradiation in vitro (0.05 Gy) and challenge irradiation (1.0 Gy) 5 h after has been studied among 320 children 3-16 years old by micronuclei test with cytochalasin B cytokinetic block. The adaptive response or the hypersensitivity phenomenon (HS) has been determined by the calculation of the number of binucleated cells with micronuclei (MN) in 1000-2000 binucleated cells. For each individual by the chi2 criteria significant differences between the frequencies of damaged cells by irradiation in challenge dose and by combined action of adaptive and challenge doses have been detected. On the base of the results obtained the connection between AR or HS and the somatic diseases of different type and the disturbancies in systems of humoral and cell immunity has been studied. It was shown that in the row of allergic diseases and tuberculous infection among the significant part of the children (approximately 50%) the HS phenomenon was registered. The connection between the HS phenomenon and inflammatory processes (without allergic components), the logopedic disturbancies wasn't observed. It was shown in the group of HS children the deviation in the cell immunity system is registered. Significant deviations in HS group in the system of the humoral immunity is observed. So by the HS phenomenon significant number of the children have the somatic diseases and the deviation in the systems of cell and humoral immunity.
Pelevina
I I
II
Aleshchenko
A V
AV
Gotlib
V Ia
VIa
Kudriashova
O V
OV
Semenova
L P
LP
Serebrianyĭ
A M
AM
D000222:Adaptation, Physiological / Q000528:radiation effects; D000293:Adolescent; D000917:Antibody Formation / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D007111:Immunity, Cellular / Q000528:radiation effects; D007239:Infections / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D015162:Micronucleus Tests; D011602:Psychophysiologic Disorders / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D014376:Tuberculosis / Q000097:blood* / Q000276:immunology / Q000503:physiopathology