title: Additional discussions regarding the altered metabolism and transport of omeprazole after long-term use of St John's wort.
authors.forename: Hong-Guang
authors.initials: HG
authors.lastname: Xie
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000897:Anti-Ulcer Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001682:Biological Availability; D001692:Biological Transport; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004336:Drug Antagonism; D004790:Enzyme Induction; D005838:Genotype; D006801:Humans; D020902:Hypericum; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009853:Omeprazole / Q000378:metabolism / Q000493:pharmacokinetics*; D028321:Plant Preparations / Q000494:pharmacology*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000897:Anti-Ulcer Agents; D028321:Plant Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; C104464:CYP3A protein, human; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; D009853:Omeprazole