Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia.
Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.
Hochhauser
Carl J
CJ
The Institute for the Study of Child Development, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 97 Paterson Street, New Brunswick, NJ, 08903, USA. Carl.Hochhauser@mssm.edu
Lewis
Michael
M
Kamen
Barton A
BA
Cole
Peter D
PD
D000339:Affect / Q000187:drug effects*; D002648:Child; D002652:Child Behavior / Q000187:drug effects*; D002675:Child, Preschool; D005493:Folic Acid Antagonists / Q000009:adverse effects; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008485:Medical Audit; D009515:New Jersey; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000523:psychology
D005493:Folic Acid Antagonists; D005938:Glucocorticoids