title: Infrared optical properties and AFM of spin-cast chitosan films chemically modified with 1,2 Epoxy-3-phenoxy-propane.
abstract: Chemical modification of spin-cast chitosan films has been performed. This modification involves the attachment of 1,2 Epoxy-3-phenoxy-propane, commonly known as glycidyl phenyl ether (GPE), to the amine group of the chitosan molecule. Optical properties of modified films have been determined in the infrared region of the spectrum using spectroscopic ellipsometry, and are reported in this paper. Special attention is paid to the infrared region where the index of refraction and extinction coefficients from 750 to 4000 cm(-1) were determined. Difference plots of IR optical data before and after chemical modification were generated to confirm that modification had occurred. Optical modeling of infrared spectroscopic ellipsometry (IRSE) data with respect to chemical bond vibrations has also been performed. This modeling involved curve fitting of resonant chemical bond absorptions using Lorentz oscillators. These oscillator models allow for comparison of modified chitosan to unmodified chitosan. The purpose of this research was to determine infrared optical constants of chemically modified chitosan films This work shows that surface chemistry of biomaterials can be studied quite sensitively with spectroscopy ellipsometry, detecting as little as 100 ng/cm(2) of GPE.
authors.affiliation: Department of Electrical Engineering, University of Nebraska, Lincoln, NE 68588, USA.
authors.forename: W H
authors.initials: WH
authors.lastname: Nosal
authors.forename: D W
authors.initials: DW
authors.lastname: Thompson
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.forename: S
authors.initials: S
authors.lastname: Sarkar
authors.forename: A
authors.initials: A
authors.lastname: Subramanian
authors.forename: J A
authors.initials: JA
authors.lastname: Woollam
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials; D002686:Chitin / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force / Q000379:methods*; D015233:Models, Statistical; D009596:Nitrophenols / Q000737:chemistry / Q000494:pharmacology*; D009991:Oscillometry; D011108:Polymers / Q000737:chemistry; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared / Q000379:methods; D013499:Surface Properties; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D004852:Epoxy Compounds; D008567:Membranes, Artificial; D009596:Nitrophenols; D011108:Polymers; D002686:Chitin; D048271:Chitosan; C007606:1,2-epoxy-3-(p-nitrophenoxy)propane