Management of subconjunctival haematoma by tissue plasminogen activator.
A patient with subconjunctival haematoma related to enterovirus 70 who was treated with tissue plasminogen activator (tPA) is reported. A 46-year-old man developed a severe subconjunctival haematoma and discharge in the left eye. Investigations, including coagulation tests, showed no abnormalities apart from a high-serum antibody titre for enterovirus 70. The polymerase chain reaction demonstrated enterovirus 70 DNA in resected conjunctival tissue, leading to a diagnosis of acute haemorrhagic conjunctivitis. The left eye was treated with a single subconjunctival injection of tPA (16 000 IU) and the subconjunctival haematoma resolved completely after 3 days. Severe subconjunctival haematoma can occur in patients with acute haemorrhagic conjunctivitis due to enterovirus 70. Subconjunctival injection of tPA may be useful for the treatment of severe subconjunctival haematoma.
Mimura
Tatsuya
T
Yamagami
Satoru
S
Funatsu
Hideharu
H
Usui
Tomohiko
T
Ono
Kyoko
K
Araie
Makoto
M
Amano
Shiro
S
D003232:Conjunctivitis, Acute Hemorrhagic / Q000188:drug therapy* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D030016:Enterovirus D, Human / Q000235:genetics / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology; D015828:Eye Infections, Viral / Q000188:drug therapy* / Q000821:virology; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006406:Hematoma / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D004279:DNA, Viral; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator