title: Reduced levofloxacin susceptibility and tetracycline resistance in a clinical isolate of Haemophilus quentini identified by 16S rRNA sequencing.
abstract: This paper reports the first case of Haemophilus quentini bacteremia with reduced susceptibility to levofloxacin and resistance to nalidixic acid identified by 16S rRNA sequencing. There was an S 84 L substitution in gyrA and an S 84 I substitution in par C. The isolate had co-resistance to ampicillin (beta-lactamase positive) and tetracycline mediated by the tet(B) gene.
authors.affiliation: Centre of Infection and Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China.
authors.forename: Gannon C
authors.initials: GC
authors.lastname: Mak
authors.forename: P L
authors.initials: PL
authors.lastname: Ho
authors.forename: Cindy W S
authors.initials: CW
authors.lastname: Tse
authors.forename: Susanna K P
authors.initials: SK
authors.lastname: Lau
authors.forename: Samson S Y
authors.initials: SS
authors.lastname: Wong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D004269:DNA, Bacterial / Q000032:analysis; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006190:Haemophilus / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D006192:Haemophilus Infections / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D064704:Levofloxacin; D009268:Nalidixic Acid / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D010641:Phenotype; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013753:Tetracycline Resistance
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S; D009268:Nalidixic Acid; D064704:Levofloxacin; D015242:Ofloxacin