title: Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production.
abstract: The total synthesis of (-)-scabronine G has been achieved in a concise manner from the (-)-Wieland-Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production.
authors.affiliation: Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Waters
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tian
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Li
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000096:biosynthesis*
chemical_list: D004224:Diterpenes; D009414:Nerve Growth Factors; C119787:scabronine G