Expression of p53 in esophageal carcinoma with multiple areas unstained by iodine.
OBJECTIVE
Esophageal squamous cell carcinoma is occasionally associated with multiple areas in the surrounding mucosa unstained with iodine.


METHODS
We examined 21 male patients with superficial esophageal carcinoma. Group 1 consisted of 4 cases of superficial esophageal carcinoma associated with multiple lesions that did not stain with iodine. Group 2 comprised 17 cases of a solitary tumor without major additional lesions in the mucosa. We assessed the correlation between clinicopathological factors, a history of tobacco and alcohol consumption, and p53 expression in the two groups.


RESULTS
We found four cases (group 1) of superficial esophageal squamous cell carcinoma where there were a total of 10 satellite tumors in addition to the main tumor. These patients tended to have a higher daily consumption of tobacco and alcohol than those in group 2. Moreover in all these group 1 cases there was intraepithelial spread of the tumors and p53 overexpression in all of the main and additional tumors.


CONCLUSIONS
We have found that higher tobacco and alcohol consumption are closely related to multiple lesions unstained by iodine and abnormal expression of the p53 gene.
Yoshikawa
Minako
M
Department of Surgery I, Gunma University Faculty of Medicine, Gunma, Japan.
Kato
Hiroyuki
H
Miyazaki
Tatsuya
T
Nakajima
Masanobu
M
Kamiyama
Youichi
Y
Fukai
Yasuyuki
Y
Tajima
Kouhei
K
Masuda
Norihiro
N
Ojima
Hitoshi
H
Tsukada
Katsuhiko
K
Kuwano
Hiroyuki
H
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004396:Coloring Agents; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000378:metabolism*; D004947:Esophagus / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007454:Iodides; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D004396:Coloring Agents; D007454:Iodides; D016159:Tumor Suppressor Protein p53; C010389:Lugol's solution