Oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines.
[reaction: see text] A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.
Yamamoto
Kana
K
Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, One Squibb Drive, New Brunswick, New Jersey 08903, USA. kana.yamamoto@bms.com
Chen
Ye Grace
YG
Buono
Frédéric G
FG
D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011188:Potassium / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry; D020122:tert-Butylhydroperoxide / Q000737:chemistry
D002254:Carbonates; D011743:Pyrimidines; D011744:Pyrimidinones; D003300:Copper; D020122:tert-Butylhydroperoxide; C037593:potassium carbonate; D011188:Potassium; C029892:cupric chloride