Model studies for the synthesis of galbonolide B.
The construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of has been constructed using an ester enolate rearrangement/silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/mercury assisted ring closure protocol.
Eshelby
James
J
Pfizer Pharmaceuticals Limited, Sandwich, Kent, CT13 9NJ, UK.
Goessman
Matthias
M
Parsons
Philip J
PJ
Pennicott
Lewis
L
Highton
Adrian
A
D007783:Lactones / Q000138:chemical synthesis
D007783:Lactones; C047787:neorustmicin A