Novel cytotoxic seco-abietane rearranged diterpenoids from Salvia prionitis.
Six novel 4,5-seco-rearranged abietane diterpenoids, including one tetracyclic diterpenoid, prionoid A (1), two tricyclic diterpenoids, prionoids B (2) and C (3), and three dicyclic diterpenoids, prionoids D (4), E (5), and F (6), were isolated from the roots of Salvia prionitis Hance (Labiatae). Their structures were elucidated using spectroscopic analysis. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it was found that 4 (IC50 = 0.41 microM) and 5 (IC50 = 0.72 microM) showed significant cytotoxic activity against P-388 and A-549 cell lines, respectively.
Chang
Jun
J
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Xu
Jun
J
Li
Mai
M
Zhao
Ming
M
Ding
Jian
J
Zhang
Jin-Sheng
JS
D045784:Abietanes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D027544:Salvia; D014961:X-Ray Diffraction
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts