Prognostic value of serum amyloid A protein in patients with acute myocardial infarction.
BACKGROUND
The relationship between plasma levels of serum amyloid A protein (SAA) concentrations and clinical course (including mortality) was investigated in patients with acute myocardial infarction (AMI).


RESULTS
The study enrolled 280 consecutive AMI patients who were admitted within 10 h of onset and were successfully reperfused by primary percutaneous coronary intervention. Plasma SAA concentrations were evaluated at 24 h after onset. The threshold of the upper quintile (325 mug/dl) was used to divide patients into 2 groups: either a high SAA (H group: > or =325 mug/dl; n=56) or low SAA (L group: <325 microg/dl; n=224). (I) Left ventricular (LV) ejection fraction in the chronic phase was significantly less in the H group than in the L group (52+/-14% vs 57+/-13%, p=0.03). (II) There were significantly more major complications in the H group than in the L group (cardiac rupture: p=0.0007, cardiogenic shock: p<0.0001; subacute thrombosis: p=0.0007; cardiac death: p=0.0003). (III) Multivariate analysis identified SAA as an independent predictor of 6-month mortality in AMI patients (risk ratio: 5.8, 95%confidence interval: 1.3-27.7, p=0.03).


CONCLUSIONS
In the setting of AMI, plasma SAA concentrations may be closely related to LV systolic dysfunction and poor patient outcomes, including mortality.
Katayama
Toshiro
T
Department of Cardiovascular Medicine, Graduate School of Biomedical Science, Nagasaki University, Japan. snowman-kt@syd.odn.ne.jp
Nakashima
Hiroshi
H
Takagi
Chisa
C
Honda
Yukiharu
Y
Suzuki
Shin
S
Iwasaki
Yoshihiro
Y
Yano
Katsusuke
K
D000208:Acute Disease; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D000685:Serum Amyloid A Protein / Q000032:analysis*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000209:etiology / Q000401:mortality
D000685:Serum Amyloid A Protein