Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis.
2-(3,4-Dimethyl-2,5-dihydro-1H-pyrrole-2-yl)-1-methylethyl pentanoate, an antifungal compound, was found to be nontoxic to RAW cells up to a concentration of 312.5 microg/ml, whereas amphotericin B was lethal to all cells at 37.5 microg/ml. The treatment of Aspergillus fumigatus-infected mice with a dose of 200.0 mg of compound/kg of body weight increased their survival rate by 60%, with a decrease in CFU in organ tissues. The protection afforded by the compound against experimental aspergillosis was found to be dose dependent.
Dabur
Rajesh
R
Institute of Biomedical Sciences, Bundelkhand University, Jhansi, India.
Diwedi
S K
SK
Yadav
V
V
Mishra
V
V
Singh
Rambir
R
Singh
H
H
Sharma
G L
GL
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005260:Female; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000494:pharmacology*; D015996:Survival Rate; D014631:Valerates / Q000494:pharmacology*
D000935:Antifungal Agents; D011758:Pyrroles; D014631:Valerates; D000666:Amphotericin B