title: Cure of multidrug-resistant Acinetobacter baumannii fixation device-related orthopedic infections in two patients with intravenous colistin.
abstract: We report our experience with two cases of fixation device-related orthopedic infections due to multidrug-resistant Acinetobacter baumannii strains. Both patients were successfully treated with intravenous administration of colistin, despite the reported poor penetration of this medication to these tissues, in the old literature. No serious colistin-associated toxicity developed and no recurrence of the infection occurred on follow up.
authors.affiliation: Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
authors.forename: Sofia K
authors.initials: SK
authors.lastname: Kasiakou
authors.forename: Kostas
authors.initials: K
authors.lastname: Fragoulis
authors.forename: George
authors.initials: G
authors.lastname: Tzagarakis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Mistidis
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kapaskelis
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Falagas
mesh_terms: D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000328:Adult; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects
chemical_list: D003091:Colistin