title: Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.
abstract: Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.
authors.affiliation: Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH-4002 Basel, Switzerland. Laszlo.revesz@novartis.com
authors.forename: Laszlo
authors.initials: L
authors.lastname: Revesz
authors.forename: Birgit
authors.initials: B
authors.lastname: Bollbuck
authors.forename: Thomas
authors.initials: T
authors.lastname: Buhl
authors.forename: Joerg
authors.initials: J
authors.lastname: Eder
authors.forename: Ronald
authors.initials: R
authors.lastname: Esser
authors.forename: Roland
authors.initials: R
authors.lastname: Feifel
authors.forename: Richard
authors.initials: R
authors.lastname: Heng
authors.forename: Peter
authors.initials: P
authors.lastname: Hiestand
authors.forename: Benedicte
authors.initials: B
authors.lastname: Jachez-Demange
authors.forename: Pius
authors.initials: P
authors.lastname: Loetscher
authors.forename: Helmut
authors.initials: H
authors.lastname: Sparrer
authors.forename: Achim
authors.initials: A
authors.lastname: Schlapbach
authors.forename: Rudolf
authors.initials: R
authors.lastname: Waelchli
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D006801:Humans; D051379:Mice; D051381:Rats; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C515300:CCR1 protein, human; C515301:Ccr1 protein, mouse; C515302:Ccr1 protein, rat; D054389:Receptors, CCR1; D019707:Receptors, Chemokine