[Advances in researches for protection and induction of cytokines to retinal neurons].
The role of cytokines in retinal functional reconstruction has been studied extensively. It has been found that brain derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), basic fibroblast growth factor (bFGF) and neurotrophin-4 (NT-4) can not only prevent retinal photoreceptor cells (RPCs) from degeneration and improve RPCs recovery after being damaged, but also promote growth and development of retinal ganglion cells (RGCs) and stimulate regeneration of axons of RGCs. Furthermore, it has been found that lens epithelium-derived growth factor (LEDGF) and human amniotic epithelial cells (HAECs) both have effects of protection on RGCs, but the role of neurotrophin-3 (NT-3) in retina will be studied in the future.
Zheng
Hao
H
Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing 100730, China.
Li
Gen-lin
GL
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology; D020934:Ciliary Neurotrophic Factor / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020933:Neurotrophin 3 / Q000494:pharmacology; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D020934:Ciliary Neurotrophic Factor; D016207:Cytokines; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D020933:Neurotrophin 3; D016222:Fibroblast Growth Factor 2; C073922:neurotrophin 4