title: Pre-mRNA trans-splicing: from kinetoplastids to mammals, an easy language for life diversity.
abstract: Since the discovery that genes are split into intron and exons, the studies of the mechanisms involved in splicing pointed to presence of consensus signals in an attempt to generalize the process for all living cells. However, as discussed in the present review, splicing is a theme full of variations. The trans-splicing of pre-mRNAs, the joining of exons from distinct transcripts, is one of these variations with broad distribution in the phylogenetic tree. The biological meaning of this phenomenon is discussed encompassing reactions resembling a possible noise to mechanisms of gene expression regulation. All of them however, can contribute to the generation of life diversity.
authors.affiliation: Laboratório de Genética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Mario Gustavo
authors.initials: MG
authors.lastname: Mayer
authors.forename: Lucile Maria
authors.initials: LM
authors.lastname: Floeter-Winter
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D014644:Genetic Variation / Q000235:genetics*; D016830:Kinetoplastida / Q000235:genetics*; D008322:Mammals / Q000235:genetics*; D009348:Nematoda / Q000235:genetics*; D010802:Phylogeny; D012322:RNA Precursors / Q000235:genetics*; D020040:Trans-Splicing / Q000235:genetics*
chemical_list: D012322:RNA Precursors