A novel MCR of isocyanates, aldehydes, and dienophiles.
[reaction: see text] A novel one-pot procedure for the three-component coupling reaction of isocyanates, aldehydes, and dienophiles (IAD reaction) has been developed. Condensation of isocyanates and aldehydes and subsequent Diels-Alder reactions with electron-deficient dienophiles furnishes endo-selective amino-substituted cyclohexenes in good yield.
Strübing
Dirk
D
Leibniz-Institut für Organische Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Neumann
Helfried
H
Hübner
Sandra
S
Klaus
Stefan
S
Beller
Matthias
M