Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.
We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.
Johnson
Christine M
CM
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523-1682, USA. christine.johnson@colostate.edu
Pandey
Rajesh
R
Sharma
Sadhna
S
Khuller
G K
GK
Basaraba
Randall J
RJ
Orme
Ian M
IM
Lenaerts
Anne J
AJ
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002214:Capsules; D004337:Drug Carriers; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D049329:Nanostructures; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents; D002214:Capsules; D004337:Drug Carriers