title: CYP3A4 inhibitors isolated from Licorice.
abstract: The extract of licorice (Glycyrrhiza uralensis FISHER, Leguminosae) showed CYP3A4 inhibitory activity with the IC50 value of 0.022 mg/ml. Bioassay-guided purification afforded nine compounds, 3-(p-hydroxyphenyl)propionic acid (1), isoliquiritigenin (2), (3R)-vestitol (3), licopyranocoumarin (4), 4-hydroxyguaiacol apioglucoside (5), liquiritin (6), liquiritigenin 7,4'-diglucoside (7), liquiritin apioside (8), and glucoliquiritin apioside (9). Among these compounds, 3, 7, and 5 showed potent CYP3A4 inhibitory activities with IC50 values of 3.6, 17, and 20 microM, respectively. Glycyrrhizin (10), a main constituent of licorice, however, was inactive for CYP3A4 inhibition.
authors.affiliation: Graduate School of Natural Science and Technology, Kanazawa University; Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Maki
authors.initials: M
authors.lastname: Aburatani
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Ahmed Atef
authors.initials: AA
authors.lastname: El-Beih
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
mesh_terms: D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D006801:Humans
chemical_list: D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors