Multicomponent synthesis of spiroisoxazolines.
A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.
Adamo
Mauro F A
MF
Centre for Synthesis and Chemical Biolog, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland. madamo@rcsi.ie
Donati
Donato
D
Duffy
Eleanor F
EF
Sarti-Fantoni
Piero
P
D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D007555:Isoxazoles; D013141:Spiro Compounds