title: Palladium-catalyzed allylation of acidic and less nucleophilic anilines using allylic alcohols directly.
abstract: The direct activation of C-O bonds in allylic alcohols by palladium complexes has been accelerated by carrying out the reactions in the presence of titanium(IV) isoproxide and 4 A molecular sieves. The acidic and less nucleophilic anilines such as diphenylamine, phenothiazine, 4-cyanoaniline, and nitroanilines are efficiently allylated under palladium catalysis using allylic alcohols as allylating reagents.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Taiwan, ROC.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Hsu
authors.forename: Kim-Hong
authors.initials: KH
authors.lastname: Gan
authors.forename: Shyh-Chyun
authors.initials: SC
authors.lastname: Yang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D000814:Aniline Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds; D010165:Palladium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry
chemical_list: D000438:Alcohols; D000498:Allyl Compounds; D000814:Aniline Compounds; D009942:Organometallic Compounds; D010165:Palladium; C102815:titanium isopropoxide; D014025:Titanium