New conjunctive reagents as cross-coupling partners en route to retinoid-like polyenes.
[structure: see text] New conjunctive reagents E-2 and Z-3 can be used, after transmetalation, in Negishi couplings with vinyl and aryl iodides. The subsequently unmasked terminal alkynes can be further manipulated to arrive at retinoid-like products.
Lipshutz
Bruce H
BH
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. lipshutz@chem.ucsb.edu
Clososki
Giuliano C
GC
Chrisman
Will
W
Chung
David W
DW
Ball
David B
DB
Howell
Jennifer
J
D000215:Acylation; D003432:Cross-Linking Reagents / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry*; D012176:Retinoids / Q000737:chemistry*
D003432:Cross-Linking Reagents; D009942:Organometallic Compounds; D011090:Polyenes; D012176:Retinoids