Low-frequency MEG activity and MRI evaluation in Parkinson's disease.
BACKGROUND
Low - frequency activity has been reported in Parkinson disease (PD). We investigated the magnetoencephalographic (MEG) recordings from PD patients and healthy volunteers in the frequency domain.


METHODS
The MEG recordings were carried out in a magnetically shielded room with a whole-head 122-channel gradiometer. Nine patients suffering from PD and 9 age and gender matched healthy subjects were included in the study. MRI with T1-w and T2-w images, was available in patients' records.


RESULTS
Frequency analysis may be usefully combined in the analysis of data sets, which contain oscillatory components. Prominent low frequencies can be seen in the spectrum obtained from the PD patients whereas in the control group the frequency range was 6Hz in the majority of channels. MRI did not disclose specific findings in any case.


CONCLUSIONS
It is suggested that the MEG could be a complementary method in the diagnostic evaluation of PD using spatial distribution of the raw data in the frequency domain.
Kotini
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Lab. of Medical Physics, Medical School, Democritus University of Thrace, University Campus, Alexandroupolis, 68100, Greece. akotin@axd.forthnet.gr
Anninos
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P
Adamopoulos
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A
Prassopoulos
P
P
D000368:Aged; D001683:Biological Clocks / Q000502:physiology; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D011237:Predictive Value of Tests; D013223:Statistics as Topic