title: [Alterations of procalcitonin and interleukin 6 after cardiopulmonary bypass in children with congenital heart disease].
abstract: Cardiac surgery induces systemic inflammatory response that may have been implicated the postoperative organ dysfunction. This inflammatory response is thought to be produced by exposing patients to proinflammatory factors. The aim of our study was to investigate alterations in procalcitonin (PCT) concentration in peripheral blood in children as the potential early indicator of complications occurring during and after surgery in extracorporeal circulation. Additionally, we evaluated the perioperative time course of IL-6.
  
  
  METHODS
  The investigations were carried out in 21 children undergoing cardiac operation with cardiopulmonary bypass (CPB). Serum concentrations of PCT and IL-6 were sequentially measured before induction of anesthesia, at the initiation of CPB, at the end of CPB, and 24 hours, and 72 hours after CPB.
  
  
  RESULTS
  There was no significant PCT-elevation at all 5 times of measurement. Levels of IL-6 increased significantly after surgery, and remained elevated for up to 1 day. Peak values correlated with the duration of CPB (r=0.68, p=0.0006).
  
  
  CONCLUSIONS
  We conclude, that cardiac surgery with CPB did not have any influence on the secretion of PCT in children. These results suggest that IL-6 was more effective than PCT to monitor patients with a favorable outcome.
authors.affiliation: Klinika Pediatrii, Kardiologii Prewencyjnej i Immunologii Wieku Rozwojowego Instytutu Pediatrii Uniwersytetu Medycznego w Lodzi. elute@poczta.onet.pl
authors.forename: Jarosław
authors.initials: J
authors.lastname: Paśnik
authors.forename: Jadwiga Anna
authors.initials: JA
authors.lastname: Moll
authors.forename: Jacek
authors.initials: J
authors.lastname: Moll
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cywińska-Bernas
authors.forename: Wojciech
authors.initials: W
authors.lastname: Mazurowski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Arendarczyk
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sysa
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Banasik
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zeman
mesh_terms: D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011498:Protein Precursors / Q000097:blood*; D013997:Time Factors
chemical_list: C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide