Physical-chemical characterization and polymorphism determination of two nimodipine samples deriving from distinct laboratories.
Knowing the characteristics of raw materials in pharmaceutical practice is both important and useful. Firstly, evaluating the physical-chemical properties of the substances that will be used must be the primary step for quality control in the pharmacy industry. This work aims at analyzing the physical-chemical characteristics of two nimodipine samples I and II derived from distinct laboratories through thermal analysis (DSC and TG/DTG), HPLC, crystallography, and microscopy. Thermal analysis showed that sample II was more unstable than I. Morphological differences concerning shape, size, and crystallinity of particles were visualized by scanning electron microscopy (SEM) and X-ray powder diffraction. To sum up, the techniques used in this study can be said to have been efficient in the characterization and evaluation of quality control of the raw material.
Cardoso
Teófilo Mazon
TM
Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. teomazon@yahoo.com
Rodrigues
Patrik Oening
PO
Stulzer
Hellen Karine
HK
Segatto Silva
Marcos Antonio
MA
do Rosário Matos
Jivaldo
J
D002121:Calcium Channel Blockers / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D009553:Nimodipine / Q000737:chemistry*; D033362:Powder Diffraction; D011786:Quality Control; D013818:Thermogravimetry; D044366:Transition Temperature; D014961:X-Ray Diffraction
D002121:Calcium Channel Blockers; D009553:Nimodipine