title: Meroterpenes from the ascidian Aplidium aff. densum.
abstract: Chemical investigation of the ascidian Aplidium aff. densum collected at Masirah Island, Oman, has resulted in the isolation of five meroterpenes: two new ones, methoxyconidiol (1) and didehydroconicol (2), and three related, known compounds, 3-5. The structures of 1 and 2 were determined by a combination of mass spectrometry and one- and two-dimensional high-field NMR techniques. Their biological activities against bacteria and human lymphoblastic cell lines were evaluated.
authors.affiliation: Laboratoire de Chimie des Biomolécules et de l'Environnement and Laboratoire de Biologie Physico-Chimique des Systèmes Intégrés, Université de Perpignan, 52 Avenue Paul Alduy, 66860 Perpignan Cedex, France.
authors.forename: Annabel
authors.initials: A
authors.lastname: Simon-Levert
authors.forename: Alban
authors.initials: A
authors.lastname: Arrault
authors.forename: Nataly
authors.initials: N
authors.lastname: Bontemps-Subielos
authors.forename: Christophe
authors.initials: C
authors.lastname: Canal
authors.forename: Bernard
authors.initials: B
authors.lastname: Banaigs
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009850:Oman; D013210:Staphylococcus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
chemical_list: D013729:Terpenes