Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production.
The total synthesis of (-)-scabronine G has been achieved in a concise manner from the (-)-Wieland-Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production.
Waters
Stephen P
SP
Laboratory for Bioorganic Chemistry and Laboratory of Biochemistry and Pharmacology, Sloan-Kettering Institute for Cancer Research, New York, New York 10021, USA.
Tian
Yuan
Y
Li
Yue-Ming
YM
Danishefsky
Samuel J
SJ
D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000096:biosynthesis*
D004224:Diterpenes; D009414:Nerve Growth Factors; C119787:scabronine G