Mitochondria: pharmacological manipulation of cell death.
Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.
Bouchier-Hayes
Lisa
L
La Jolla Institute for Allergy and Immunology, Department of Cellular Immunology, San Diego, California 92121, USA.
Lartigue
Lydia
L
Newmeyer
Donald D
DD
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D015195:Drug Design; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D004364:Pharmaceutical Preparations