title: Duplication of the hypophysis associated with precocious puberty: presentation of two cases and review of pituitary embryogenesis.
abstract: Pituitary duplication is a rare malformation commonly associated with other major neural/craniofacial anomalies, easily shown by magnetic resonance imaging. The authors describe two girls with duplication of the pituitary gland and thickening of the hypothalamus, facial dysmorphism and precocious pubertal development. The pathogenesis of pituitary duplication and its relationship with precocious pubertal development are discussed.
authors.affiliation: Serviço de Endocrinologia, Hospital Felício Rocho, Belo Horizonte, MG.
authors.forename: Gustavo Cancela
authors.initials: GC
authors.lastname: de Penna
authors.forename: Márcia Porto
authors.initials: MP
authors.lastname: Pimenta
authors.forename: Juliana B
authors.initials: JB
authors.lastname: Drummond
authors.forename: Marta
authors.initials: M
authors.lastname: Sarquis
authors.forename: José Carlos T
authors.initials: JC
authors.lastname: Martins
authors.forename: Rodrigo C
authors.initials: RC
authors.lastname: de Campos
authors.forename: Eduardo Pimentel
authors.initials: EP
authors.lastname: Dias
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000002:abnormalities* / Q000196:embryology; D011629:Puberty, Precocious / Q000209:etiology*