title: AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters.
abstract: We cloned a gene, abeM, for a multidrug efflux pump from Acinetobacter baumannii using Escherichia coli as the host. Sequence analysis revealed that AbeM is a member of the MATE family of pumps. AbeM was found to be an H(+)-coupled multidrug efflux pump and a unique member of the MATE family.
authors.affiliation: Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: Xian-Zhong
authors.initials: XZ
authors.lastname: Su
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Tohru
authors.initials: T
authors.lastname: Mizushima
authors.forename: Teruo
authors.initials: T
authors.lastname: Kuroda
authors.forename: Tomofusa
authors.initials: T
authors.lastname: Tsuchiya
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D017920:Antiporters / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001692:Biological Transport; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development; D005798:Genes, Bacterial; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D017494:Proton Pumps / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D013379:Substrate Specificity
chemical_list: D000900:Anti-Bacterial Agents; D017920:Antiporters; D004269:DNA, Bacterial; D017494:Proton Pumps