title: Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study.
abstract: Rosacea is a chronic facial dermatosis with a progressive course, which is characterized by the presence of erythema, papules, pustules, telangiectasias and sebaceous gland hyperplasia. However, the aetiology is still unknown; genetic predisposition, gastrointestinal disorders (Helicobacter pylori), infestations with Demodex folliculorum and environmental stimuli are considered to be involved in the inflammatory process. A metabolite of nicotinamide, 1-methylnicotinamide (MNA(+)), has anti-inflammatory properties, and this is the first study to test the effectiveness of this agent in treating rosacea. In total, 34 patients with rosacea were treated with a gel containing 0.25% MNA(+) as a chloride salt, twice daily for 4 weeks, after which improvement was observed in 26/34 cases. The improvement was good in 9/34 and moderate in 17/34, but no clinical effect was noted in seven subjects. In only one case was skin irritation given as the reason for treatment withdrawal. These results indicate that MNA(+) might be a useful agent for treating rosacea.
authors.affiliation: Department of Dermatology, Medical University of Lodz, Poland. wozniacka@bmp.net.pl
authors.forename: A
authors.initials: A
authors.lastname: Wozniacka
authors.forename: M
authors.initials: M
authors.lastname: Wieczorkowska
authors.forename: J
authors.initials: J
authors.lastname: Gebicki
authors.forename: A
authors.initials: A
authors.lastname: Sysa-Jedrzejowska
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002908:Chronic Disease; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010865:Pilot Projects; D012393:Rosacea / Q000188:drug therapy*
chemical_list: D003879:Dermatologic Agents; D005782:Gels; D009536:Niacinamide; C024058:N(1)-methylnicotinamide