title: [Glucocorticoids reduce acute postoperative pain].
abstract: Glucocorticoids have been used for postsurgical pain relief over the last 30 years. They reduce prostaglandins by inhibiting phospholipase A2 and the expression of COX-2 mRNA. The evidence for an analgesic effect is best after oral, orthopaedic, laparoscopic and perianal surgery. Their anti-emetic properties in addition to the analgesic effects make them particularly useful perioperatively.
authors.affiliation: Anestesiavdelingen, Rikshospitalet, 0027 Oslo. luisro@medisin.uio.no
authors.forename: Luis
authors.initials: L
authors.lastname: Romundstad
authors.forename: Harald
authors.initials: H
authors.lastname: Breivik
authors.forename: Audun
authors.initials: A
authors.lastname: Stubhaug
mesh_terms: D000208:Acute Disease; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage; D019317:Evidence-Based Medicine; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control; D011292:Premedication
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000932:Antiemetics; D016861:Cyclooxygenase Inhibitors; D005938:Glucocorticoids; D008775:Methylprednisolone