[Hemorheologic changes in patients with chronic hepatitis B].
OBJECTIVE
To study the variation of the hemorheology in patients with chronic hepatitis B and study its relations with HBV DNA, liver function and oxidative stress markers.


METHODS
Indices for hemorheology, oxidative stress markers, liver function, and HBV DNA were measured in 55 patients with chronic hepatitis B and correlative analysis was made.


RESULTS
The low-shear whole blood viscosity (BV), RBC aggregation index were significantly higher in hepatitis B group than those in the control group (P < 0.05), Hematocrit (HCT), the low-shear BV, RBC aggregation index were significantly higher in the patients whose ALT was higher than the patients whose ALT was normal and the controls. No significant difference was found in HBV DNA and indices of hemorheology (P > 0.05), nor in indices of hemorheology and oxidative stress markers (P > 0.05).


CONCLUSIONS
There is disturbance of microcirculation and oxidative stress in the body of patients with chronic hepatitis B. The hemorheology and oxidative stress markers should be regarded as useful indexes in patients with chronic hepatitis B in addition to HBV markers.
Yang
Yan
Y
Department of Liver Disease, Qilu Hospital, Shandong University, Jinan 250012, China.
Wang
Kai
K
Han
Li-yan
LY
Li
Xin-he
XH
Wang
Hui-min
HM
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001809:Blood Viscosity; D002648:Child; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D006400:Hematocrit; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D014810:Vitamin E / Q000097:blood; D055815:Young Adult
D004279:DNA, Viral; D014810:Vitamin E; D008315:Malondialdehyde; D000410:Alanine Transaminase