[Amiodarone-induced thyrotoxicosis: a diagnostic and therapeutic challenge].
Amiodaron is a widely used antiarrhytmic drug in a number of cardiac conditions. The most common side effects affect the thyroid gland (14-18% of treated patients) resulting in hypothyroidism or hyperthyroidism. We describe a complex case of amiodaron-induced thyrotoxicosis (AIT) and discuss the pathogenesis of the different subtypes (AIT I, II and mixed forms) and the diagnostic and therapeutic challenges in such patients.
Schuetz
Ph
P
Abteilung Innere Medizin, Abteilung Endokrinologie, Universitätsspital Basel. PhilippSchuetz@hotmail.com
Eriksson
U
U
Christ-Crain
M
M
Zulewski
H
H
Miller
B
B
D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000188:drug therapy*; D001282:Atrial Flutter / Q000188:drug therapy*; D002231:Carbimazole / Q000008:administration & dosage / Q000009:adverse effects; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D018805:Sepsis / Q000139:chemically induced; D013960:Thyroid Function Tests; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D013956:Antithyroid Agents; D002231:Carbimazole; D000638:Amiodarone