Differential effects of vigabatrin and zonisamide on the neuropeptide Y system in the hippocampus of seizure prone gerbil.
Changed neuropeptide Y (NPY) system in the hippocampus has been reported in various experimental epileptic models. However, there have been little data concerning the alteration in the NPY system in the epileptic hippocampus following treatment of anti-epileptic drugs (AEDs). In the present study, therefore, we performed analyses of effects of vigabatrin (VGB) and zonisamide (ZNS) treatment on the NPY system in the hippocampus of the seizure sensitive (SS) gerbils. In SS gerbil, NPY immunoreactivity in the hippocampus was lower than that in seizure resistant gerbil. Following VGB treatment, the number of NPY immunoreactive neurons and NPY mRNA expression were increased in the hilus and the hippocampus proper. In contrast, ZNS treatment markedly elevated only the density of NPY immunoreactive fibers in the dentate gyrus, not in the hippocampus proper, as compared with saline-treated animals. These patterns were observed in the dose-dependent manners. These findings suggest that AEDs treatments may distinctly affect the NPY system in the SS gerbil hippocampus.
Kwak
Sung-Eun
SE
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
Kim
Ji-Eun
JE
Kim
Duk-Soo
DS
Won
Moo-Ho
MH
Choi
Hui-Chul
HC
Kim
Yeong-In
YI
Song
Hong-Ki
HK
Choi
Soo-Young
SY
Kang
Tae-Cheon
TC
D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D017403:In Situ Hybridization; D007555:Isoxazoles / Q000378:metabolism / Q000494:pharmacology*; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism*; D012640:Seizures / Q000503:physiopathology; D020888:Vigabatrin / Q000378:metabolism / Q000494:pharmacology*; D000078305:Zonisamide
D000927:Anticonvulsants; D007555:Isoxazoles; D009478:Neuropeptide Y; D000078305:Zonisamide; D020888:Vigabatrin