title: Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
abstract: The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, H-7624 Pécs, Szigeti. u. 12, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Bánvölgyi
authors.forename: László
authors.initials: L
authors.lastname: Pálinkás
authors.forename: Tímea
authors.initials: T
authors.lastname: Berki
authors.forename: Natalie
authors.initials: N
authors.lastname: Clark
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Grant
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Helyes
authors.forename: Gábor
authors.initials: G
authors.lastname: Pozsgai
authors.forename: János
authors.initials: J
authors.lastname: Szolcsányi
authors.forename: Susan D
authors.initials: SD
authors.lastname: Brain
authors.forename: Erika
authors.initials: E
authors.lastname: Pintér
mesh_terms: D000276:Adjuvants, Immunologic / Q000633:toxicity; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000172:deficiency / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D004195:Disease Models, Animal; D004224:Diterpenes / Q000008:administration & dosage; D004427:Ear Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009504:Neutrophils / Q000378:metabolism; D010081:Oxazolone / Q000633:toxicity*; D010880:Piperidines / Q000008:administration & dosage; D011812:Quinuclidines / Q000008:administration & dosage; D050916:TRPV Cation Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000502:physiology*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D004224:Diterpenes; D010880:Piperidines; D011812:Quinuclidines; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; C085215:SR 140333; D010081:Oxazolone; C024353:resiniferatoxin; D015740:Calcitonin Gene-Related Peptide