Carbimazole-induced hypothyroidism causes the adrenal atrophy in 10 days' prenatally treated albino rats.
OBJECTIVE
To investigate the effects of carbimazole-induced hypothyroidism, and simultaneous administration of thyroxine (thyroid hormone analogue) on the adrenal glands of 10 days' prenatally treated albino rats.


METHODS
A comparative study.


METHODS
Department of Anatomy, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi, from 15th July 2001 to 31st August 2001.


METHODS
Ten days old albino rats of either gender, which were delivered by their respective mothers which were originally obtained from Charles River Breeding Laboratories, Brooklyn, Massachusetts, USA, and were cross bred, housed and maintained on the balanced diet in the Animal House of BMSI, JPMC, Karachi. Eighteen prenatally treated albino rats of 10 days old were used in the experiment and divided into three groups: X, Y and Z, comprising 06 animals in each group, i.e. from carbimazole treated mothers (X), carbimazole plus thyroxine treated mothers (Y), and controlled mothers (Z). At the end of 10th postnatal day all the animals were sacrificed, their adrenal glands were removed, fixed, sectioned, and stained with H&E. The adrenal histology with relation to its width of cortex, zones and number of cells in different zones of cortex were studied.


RESULTS
Carbimazole-induced hypothyroidism causes the adrenal atrophy in the adrenals of 10 days' prenatally treated albino rats by decreasing the total width of cortex and its zones especially zona fasciculata.


CONCLUSIONS
Carbimazole-induced hypothyroidism by carbimazole causes the shrinkage of adrenal cortex in 10 days prenatally treated albino rats.
Sarwar
Ghulam
G
Department of Anatomy, Fatima Jinnah Dental College, Karachi.
Parveen
Sughra
S
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology*; D000818:Animals; D013956:Antithyroid Agents / Q000009:adverse effects; D002231:Carbimazole / Q000009:adverse effects; D007037:Hypothyroidism / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology; D015383:Zona Fasciculata / Q000187:drug effects / Q000473:pathology
D013956:Antithyroid Agents; D002231:Carbimazole; D013974:Thyroxine