Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia.
Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2 LTR DNA). Although total HIV DNA was detected in 60 2 LTR DNA-negative samples, the absence of 2 LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.
McDermott
Jennifer L
JL
Section of Microbiology, School of Medicine, University of Genova, Largo Rosanna Benzi, 10, 16132 Genova (EC), Italy.
Martini
Isabella
I
Ferrari
Davide
D
Bertolotti
Francesca
F
Giacomazzi
Claudio
C
Murdaca
Giuseppe
G
Puppo
Francesco
F
Indiveri
Francesco
F
Varnier
Oliviero E
OE
D023241:Antiretroviral Therapy, Highly Active; D004279:DNA, Viral / Q000097:blood* / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy; D016325:HIV Long Terminal Repeat / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D014766:Viremia / Q000188:drug therapy* / Q000821:virology; D016662:Virus Integration; D014779:Virus Replication / Q000187:drug effects
D004279:DNA, Viral