title: Small peptides as modular catalysts for the direct asymmetric aldol reaction: ancient peptides with aldolase enzyme activity.
abstract: Simple peptides and their analogues having a primary amino group as the catalytic residue mediate the direct asymmetric intermolecular aldol reaction with high stereoselectivity and furnish the corresponding aldol products with up to 99% ee; this intrinsic ability of highly modular peptides may explain the initial molecular evolution of aldolase enzymes.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
authors.forename: Weibiao
authors.initials: W
authors.lastname: Zou
authors.forename: Ismail
authors.initials: I
authors.lastname: Ibrahem
authors.forename: Pawel
authors.initials: P
authors.lastname: Dziedzic
authors.forename: Henrik
authors.initials: H
authors.lastname: Sundén
authors.forename: Armando
authors.initials: A
authors.lastname: Córdova
mesh_terms: D002384:Catalysis; D019143:Evolution, Molecular; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D010455:Peptides; D005634:Fructose-Bisphosphate Aldolase