title: A single-center experience of late retransplantation of the liver.
abstract: Liver retransplantation is considered to carry a higher risk than primary transplantation. However, there are an increasing number of retransplant candidates, especially owing to late graft failure. The aim of this study was to analyze a single-center experience in late liver retransplantation. The overall rate of primary retransplantation was 11.4% (28 re-OLT out of 245 primary OLT); the 14 (52%) who underwent retransplantation at more than 3 months after the first transplant were analyzed by a medical record review. Causes of primary graft failure leading to retransplantation were chronic hepatic artery thombosis in five cases (36%); recurrent HCV cirrhosis in four cases (29%); chronic rejection in two cases (14%); veno-occlusive disease; hepatic vein thrombosis or idiopathic graft failure in one case each (7%). UNOS status at re-OLT was always 2A, all patients were hospitalized; three were intensive care unit bound. ICU and total hospital stay had been 7 +/- 5 and 28 +/- 16 days, respectively. One- and 2-year patient and graft survivals were 84% and 62% and 67% and 67%, respectively. Death occurred in four patients. Two out of the three recovered in ICU at the time of retransplantation, at a median interval of 15 +/- 9 days after retransplantation. The survival rate after late retransplantation is improving, and this option should be considered to be a efficient way to save lives, especially by defining the optimal timing for retransplantation.
authors.affiliation: Department of Surgery and Transplantation, University Hospital of Udine, Udine, Italy.
authors.forename: G L
authors.initials: GL
authors.lastname: Adani
authors.forename: U
authors.initials: U
authors.lastname: Baccarani
authors.forename: A
authors.initials: A
authors.lastname: Risaliti
authors.forename: M
authors.initials: M
authors.lastname: Sainz-Barriga
authors.forename: D
authors.initials: D
authors.lastname: Lorenzin
authors.forename: G
authors.initials: G
authors.lastname: Costa
authors.forename: P
authors.initials: P
authors.lastname: Toniutto
authors.forename: G
authors.initials: G
authors.lastname: Soardo
authors.forename: D
authors.initials: D
authors.lastname: Montanaro
authors.forename: P
authors.initials: P
authors.lastname: Viale
authors.forename: G
authors.initials: G
authors.lastname: Della Rocca
authors.forename: F
authors.initials: F
authors.lastname: Bresadola
mesh_terms: D000328:Adult; D006499:Hepatic Artery; D006801:Humans; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D008499:Medical Records; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D013927:Thrombosis; D013997:Time Factors