title: Splicing of a rare class of introns by the U12-dependent spliceosome.
abstract: Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.
authors.affiliation: Max Planck Institute for Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, D-37077 Göttingen, Germany. cwill1@gwdg.de
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Will
authors.forename: Reinhard
authors.initials: R
authors.lastname: Lührmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D006801:Humans; D007438:Introns; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000235:genetics / Q000378:metabolism*; D017381:Spliceosomes / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D012342:RNA, Small Nuclear; C096986:U12 small nuclear RNA; C405484:U2 small nuclear RNA