title: Prospects for the resistance to HIV protease inhibitors: current drug design approaches and perspectives.
abstract: One of the major challenges raised by HIV chemotherapy is the insurgence of viral resistance to drugs. Resistance to antiviral therapy has been observed for each of the different classes of anti-viral drugs: nucleoside reverse-transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors. The crucial question for AIDS drug research community is: Should we continue the search of new anti-HIV drugs which can overcome HIV resistance insurgence or should we consider resistance to anti-HIV drugs as a futile challenge? This review, focussed specifically on HIV antiprotease drugs, highlights the different strategies which have been developed to design new anti-protease drugs which could overcome HIV resistance, and also reviews the different classes of compounds (peptidomimetic or non-peptidomimetic) actually under investigation in order to face the problem of HIV resistance to drug.
authors.affiliation: Laboratoire de Chimie Biomoléculaire, INSERM U623, Institut de Biologie du Développement de Marseille (IBDM), Université de la Méditerranée, Parc scientifique de Luminy, 163 avenue de Luminy, case 901, 13288 Marseille cedex 9, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Burlet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pietrancosta
authors.forename: Younes
authors.initials: Y
authors.lastname: Laras
authors.forename: Cédrik
authors.initials: C
authors.lastname: Garino
authors.forename: Gilles
authors.initials: G
authors.lastname: Quéléver
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Kraus
mesh_terms: D015195:Drug Design; D024882:Drug Resistance, Viral; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors