Optical resolution by crystallization from melt using enantiomer derivatives as resolving agents: nonlinear behavior of resolving agent mixtures.
Substituted racemic 1-phenylethylamine derivatives were reacted in molten phase with chiral N-substituted 1-phenylethylamine dicarboxylic acid derivatives (4-9), and their mixtures (e.g., 4+6, 7+8, etc.) in different ratios, and the crystalline quasi-racemic diastereomers so formed were separated. Nonlinear behavior of the mixtures of resolving agents having related structure and considerable positive and negative chiral-chiral interactions were observed.
Schindler
József
J
Research Group for Organic Chemical Technology, Budapest University of Technology and Economics, Hungary. jschindler@mail.bme.hu
Egressy
Márton
M
Bálint
József
J
Hell
Zoltán
Z
Fogassy
Elemér
E