title: Evaluation of serum levels of solubilized adhesion molecules in patients with aortocoronary saphenous vein grafts.
abstract: OBJECTIVE
  To assess the diagnostic importance of serum-solubilized adhesion molecules, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, sE-selectin and sP-selectin in aortocoronary saphenous vein graft disease.
  
  
  METHODS
  The study population was composed of two groups consisting of 41 patients with saphenous vein graft stenosis (stenosis group) and 43 patients without saphenous vein graft stenosis (no-stenosis group) based on the results of coronary angiography. All patients underwent coronary artery bypass graft operation involving the use of at least one saphenous vein graft for bypass. At the time of cardiac catheterization, it had been more than 1 year since the operation.
  
  
  RESULTS
  Serum level of sP-selectin was significantly higher in the stenosis group than in the no-stenosis group (72.9+/-21.7 versus 48.7+/-18.6 ng/ml, P<0.001). No differences were found between the two groups with respect to serum levels of sE-selectin, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Multivariate analysis revealed that only serum levels of sP-selectin, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were independently correlated with the stenosis of saphenous vein grafts. A cutoff value of serum sP-selectin >57.5 ng/ml yields a specificity of 79.5%, a sensitivity of 73.3% and a positive predictive value of 80.5% for saphenous vein graft stenosis.
  
  
  CONCLUSIONS
  In this study, sP-selectin level was found to be significantly higher in the group that had late aortocoronary saphenous vein bypass graft disease. This result suggests that platelet activation may play a causal role in late graft disease.
authors.affiliation: Department of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. sevgidursun06@yahoo.com
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.forename: Ali R
authors.initials: AR
authors.lastname: Erbay
authors.forename: Orhan
authors.initials: O
authors.lastname: Maden
authors.forename: Serkan
authors.initials: S
authors.lastname: Topaloglu
authors.forename: Cemal
authors.initials: C
authors.lastname: Ozbakir
authors.forename: Ozcan
authors.initials: O
authors.lastname: Ozdemir
authors.forename: Kerim
authors.initials: K
authors.lastname: Cagli
authors.forename: Ahmet D
authors.initials: AD
authors.lastname: Demir
authors.forename: Mustafa
authors.initials: M
authors.lastname: Soylu
authors.forename: Halil L
authors.initials: HL
authors.lastname: Kisacik
authors.forename: Sule
authors.initials: S
authors.lastname: Korkmaz
mesh_terms: D000368:Aged; D050197:Atherosclerosis; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015539:Platelet Activation; D011237:Predictive Value of Tests; D012501:Saphenous Vein / Q000473:pathology / Q000637:transplantation*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules