title: Targeting the chemokine receptor CXCR3 and its ligand CXCL10 in the central nervous system: potential therapy for inflammatory demyelinating disease?
abstract: Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -- chemoattractant cytokines -- regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.
authors.affiliation: The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark. torbenls@dadlnet.dk
authors.forename: Torben Lykke
authors.initials: TL
authors.lastname: Sorensen
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000378:metabolism*; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000378:metabolism*
chemical_list: C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D008024:Ligands; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine