[Mechanisms of the erythropoiesis-stimulating effect of skullcap (Scutellaria baicalensis) extract].
The qualitative and quantitative composition of the hemopoietic tissue has been studied and the processes of erythropoiesis regeneration in mice treated with cyclophosphamide and skullcap (Scutellaria Baicalensis) extract against a background of cyclophosphamide treatment have been studied. The skullcap extract produced a significant erythropoiesis-stimulating effect under the conditions of cytostatic myclosuppression. Activation of the erythroid branch of hemopoiesis was related to the growing number of erythropoiesis precursor cells in the bone marrow and also to an increase in the concentration of humoral factors of erythropoiesis regulation in the peripheral blood serum.
Udut
E V
EV
Zhdanov
V V
VV
Gur'iantseva
L A
LA
Minakova
M Iu
MIu
Dygaĭ
A M
AM
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D004920:Erythropoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D031364:Scutellaria baicalensis / Q000737:chemistry
D018906:Antineoplastic Agents, Alkylating; D010936:Plant Extracts; D003520:Cyclophosphamide