title: Effect of aqueous extracts of Ecballium elaterium rich, in the rabbit model of rhinosinusitis.
abstract: This study was designated to investigate anti-inflammatory effect of aqueous extract of Ecballium elaterium, which is topically applied for treatment of rhinosinusitis as a traditional folk medicine in Turkey. Therapeutic potential of E. elaterium as an anti-inflammatory agent was examined by measurement of NO* metabolites in a rabbit model of rhinosinusitis. The results showed that both activity of NOS enzyme and concentration of NO* metabolites were significantly reduced by topical administration of E. elaterium extract in therapy group as compared to the control. Thus, the data suggest E. elaterium extract may have the potential to be used as anti-inflammation agent, and can be used in the treatment of rhinosinusitis diseases.
authors.affiliation: Department of Otolaryngology, Haydarpasa State Hospital for Research and Education, Uskudar, Istanbul, Turkey. celiluslu@hotmail.com
authors.forename: Celil
authors.initials: C
authors.lastname: Uslu
authors.forename: R Murat
authors.initials: RM
authors.lastname: Karasen
authors.forename: Fikrettin
authors.initials: F
authors.lastname: Sahin
authors.forename: Seyithan
authors.initials: S
authors.lastname: Taysi
authors.forename: Fatih
authors.initials: F
authors.lastname: Akcay
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D011817:Rabbits; D012852:Sinusitis / Q000378:metabolism / Q000382:microbiology / Q000628:therapy*; D013203:Staphylococcal Infections / Q000150:complications; D013211:Staphylococcus aureus
chemical_list: D000890:Anti-Infective Agents; D009569:Nitric Oxide