Cotard's syndrome in adolescents and young adults: a possible onset of bipolar disorder requiring a mood stabilizer?
This paper reviews all reports of Cotard's syndrome (délire de négation) in adolescents and young adults and summarizes four consecutive cases seen at our institution during the past 10 years. Cotard's syndrome occurs infrequently in young people (19 cases have been reported so far, including a 15-year-old boy who died at hospital) but appears to be a severe syndrome in adolescents of both genders. Ten patients received electroconvulsive therapy (ECT) despite their young age. Among the 14 cases reported with at least a 2-year follow-up, 13 patients (93%; 11 female) exhibited a bipolar outcome. The use of mood stabilizers should be considered in this rare, but potentially severe, condition.
Soultanian
Charlotte
C
Department of Psychiatry, AP-HP, Hôpital Saint Antoine, Paris, France.
Perisse
Didier
D
Révah-Levy
Anne
A
Luque
Rogelio
R
Mazet
Philippe
P
Cohen
David
D
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000209:etiology* / Q000523:psychology; D001828:Body Image; D002220:Carbamazepine / Q000627:therapeutic use; D003702:Delusions / Q000150:complications / Q000188:drug therapy*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D008094:Lithium / Q000627:therapeutic use; D011613:Psychotherapy; D013577:Syndrome
D000927:Anticonvulsants; D018692:Antimanic Agents; D002220:Carbamazepine; D008094:Lithium