title: [Study on the characteristics of inheritance and epidemiology in one pedigree with gallstone disease].
abstract: OBJECTIVE
  To study the characteristics of inheritance and epidemiology of gallstone disease in one pedigree.
  
  
  METHODS
  A gallbladder disease-specific questionnaire was administered to all family members to ascertain histories of cholecystectomy and other medical conditions as well as anthropometrical data. Laboratory examination and ultrasonography were performed to determine the existence of gallstone.
  
  
  RESULTS
  One hundred and thirteen members of four generations in the index family were enrolled in the study. The prevalence of gallstone in females (34.48%) was higher than in males (23.64%) but with no significant difference. The prevalence in the second and third generations (52%) was higher than in others (20%) (P < 0.05). The heritability and standard error showed as 86.38% +/- 46.46% in I generations. Body mass index, histories of hypertension, hyperlipidemia and blood glucose were positively related to gallstone disease (P = 0.012, < 0.01, 0.017, 0.043, respectively) in this family. Gallstone disease was not significantly related to history of diabetes, daily alcohol or diet habit. Plasma cholesterol and triglyceride levels were not correlated with gallstone disease.
  
  
  CONCLUSIONS
  Gallstone disease presented aggregation in the family and was in accordance with the characteristics of autosomal dominant inheritance. Being female, obesity, hypertension and history of hyperlipidemia might serve as risk factors to this family.
authors.affiliation: Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Surgery, Shanghai 200025, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
authors.forename: Tian-quan
authors.initials: TQ
authors.lastname: Han
authors.forename: Xing-xing
authors.initials: XX
authors.lastname: Cai
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shi-yong
authors.initials: SY
authors.lastname: Yang
authors.forename: Zhao-yan
authors.initials: ZY
authors.lastname: Jiang
authors.forename: Sheng-dao
authors.initials: SD
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005192:Family Health; D005260:Female; D042882:Gallstones / Q000453:epidemiology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010375:Pedigree; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires