title: A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.
abstract: Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
authors.forename: Atchara
authors.initials: A
authors.lastname: Tempeam
authors.forename: Nopporn
authors.initials: N
authors.lastname: Thasana
authors.forename: Chitkavee
authors.initials: C
authors.lastname: Pavaro
authors.forename: Wongsatit
authors.initials: W
authors.lastname: Chuakul
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
mesh_terms: D002247:Carbon Isotopes; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry* / Q000145:classification; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D011522:Protons; D012015:Reference Standards; D013237:Stereoisomerism
chemical_list: D002247:Carbon Isotopes; D004224:Diterpenes; D018942:Macrolides; D011522:Protons; C483695:rediocide A; C507469:rediocide G