title: Recurrent venous thrombosis with factor V Leiden mutation.
abstract: A patient who presented with recurrent venous thrombosis is reported. Following an episode of spontaneous deep vein thrombosis of the lower limb he was started on oral anticoagulant therapy, which he discontinued. He presented with cerebral venous thrombosis and improved partially with anticoagulant therapy. Evaluation for hypercoagulable states revealed factor V Leiden mutation by polymerized chain reaction method. Long-term anticoagulation has been planned. Evaluation for factor V Leiden mutation is always warranted in patients presenting with spontaneous thrombosis, especially if there is recurrent thrombosis.
authors.affiliation: Department of Neurosciences, Apollo Speciality Hospitals, Lake View Road, KK Nagar, Madurai, Tamil Nadu.
authors.forename: S
authors.initials: S
authors.lastname: Meenakshi-Sundaram
authors.forename: Rohini
authors.initials: R
authors.lastname: Sridhar
authors.forename: J J
authors.initials: JJ
authors.lastname: Jithendrian
authors.forename: R N
authors.initials: RN
authors.lastname: Durai
authors.forename: M J
authors.initials: MJ
authors.lastname: Arunkumar
authors.forename: Bharathi
authors.initials: B
authors.lastname: Sundar
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D012008:Recurrence; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V