The alpha-helix folds more rapidly at the C-terminus than at the N-terminus.
The helix-coil dynamics of different sections of an alpha-helical model peptide were observed separately by nanosecond temperature jump experiments with IR detection on a series of isotopically labeled peptides. The results show that the helix-coil dynamics of the alpha-helical C-terminus are faster than those of the N-terminus.
Pozo Ramajo
Angela
A
Department of Chemistry and Surface Science Research Centre, University of Liverpool, Liverpool L69 3BX, UK.
Petty
Sarah A
SA
Starzyk
Agnieszka
A
Decatur
Sean M
SM
Volk
Martin
M
D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D013696:Temperature; D013997:Time Factors
D010455:Peptides