title: Risk of high-grade cervical intraepithelial neoplasia among young women with abnormal screening cytology.
abstract: OBJECTIVE
  To estimate the risk of high-grade cervical disease among teenage women with abnormal cytology.
  
  
  METHODS
  Retrospective analysis of a prospectively collected database of females undergoing colposcopy for abnormal screening cytology in an urban dysplasia clinic.
  
  
  RESULTS
  Among 211 eligible teens, high-grade squamous intraepithelial lesions were found in 17 (8%) on referral cytology and 4 (2%) on repeat cytology. High-grade cervical intraepithelial neoplasia was found in colposcopic biopsy specimens 30 (15%) of young women; no patient had cancer. Age, referral Pap, ethnicity, parity, HIV serostatus, history of other sexually transmitted infections, smoking, oral contraceptive use condom use, use of medroxyprogesterone, age at first intercourse, and the number of years since first intercourse did not predict increasing risk of high-grade cervical intraepithelial neoplasia (CIN). In logistic regression, both number of partners > or = 5 (p = 0.003) and a finding of any squamous intraepithelial lesion in a Pap test repeated at colposcopy (p = 0.025) were significant predictors of CIN 2,3, though the predictive value of the model was weak (R = 0.12).
  
  
  CONCLUSIONS
  Only 15% of teens with abnormal cytology have high-grade CIN. Colposcopy may be most appropriate for those with multiple partners and squamous intraepithelial lesions on repeat Pap.
authors.affiliation: Department of Obstetrics and Gynecology, the Southern Illinois University School of Medicine, Springfield, 62794, USA. smassad@siumed.edu
authors.forename: Stewart L
authors.initials: SL
authors.lastname: Massad
authors.forename: Stephen
authors.initials: S
authors.lastname: Markwell
authors.forename: Helen E
authors.initials: HE
authors.lastname: Cejtin
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Collins
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology; D002641:Chicago; D003127:Colposcopy; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D016015:Logistic Models; D008403:Mass Screening; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology*