title: Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study.
abstract: The purpose of the present study was to investigate the changes in the cognitive dysfunctions of patients with obsessive-compulsive disorder (OCD) over a 1-year period of pharmacological treatment. Twenty-one OCD patients and 20 normal subjects underwent neuropsychological tests and clinical evaluations on three separate occasions (baseline, 4 months, and 1 year after the start of medications). OCD patients continued to show significant impairments in the following cognitive measures compared with the normal controls: accuracy of immediate and delayed recall on the Rey-Osterrieth complex figure tests, the numbers of responses on the category fluency test, the response time on the trail making test--part A, and the number of perseverative response and perseverative errors on the Wisconsin card sorting test. The findings in this study suggested that impaired performance on cognitive domains, such as visuospatial memory and verbal fluency may underline the pathology of OCD.
authors.affiliation: Neuroscience Institute, SNU-MRC, and Department of Psychiatry, Seoul National University, Seoul, Korea.
authors.forename: Kyu Sik
authors.initials: KS
authors.lastname: Roh
authors.forename: Min Sup
authors.initials: MS
authors.lastname: Shin
authors.forename: Myung-Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Ha
authors.forename: Yong-Wook
authors.initials: YW
authors.lastname: Shin
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lee
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000328:Adult; D001245:Association Learning; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors