Effect of enzymatic degradation on the release kinetics of model drug from Pluronic F127/poly(lactic acid) nano-particles.
Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymer (PEO-PPO-PEO) to obtain amphiphilic PLA-F127-PLA block copolymers. The effect of enzymatic degradation on the release behaviors of hydrophobic model drug 9-(methylaminomethyl)anthracene (MAMA) from PLA-F127-PLA nano-particles with vesicular structure was studied by UV-Vis spectroscopy. It was observed that the release rate of MAMA from PLA-F127-PLA nano-particles with the enzymatic degradation varied with temperature due to the activity of the enzyme with temperature. However, the enzyme concentration has negligible effect on the release rates of MAMA.
Xiong
X Y
XY
School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China.
Tam
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KC
Gan
L H
LH
D000873:Anthracenes / Q000008:administration & dosage / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019286:Endopeptidase K / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D049329:Nanostructures; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D020442:Poloxamer / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
C103444:9-(methylaminomethyl)anthracene; D000873:Anthracenes; D005079:Excipients; D004364:Pharmaceutical Preparations; D011091:Polyesters; D011108:Polymers; D020442:Poloxamer; D019344:Lactic Acid; C033616:poly(lactide); D019286:Endopeptidase K