The functional interface between Salmonella and its host cell: opportunities for therapeutic intervention.
Salmonella is a facultative intracellular pathogen that causes diseases ranging from self-limiting enteritis to typhoid fever. This bacterium uses two type III secretion systems to deliver effector proteins directly into the host cell to promote infection and disease. Recent characterization of these virulence proteins and their host-cell targets is uncovering the molecular mechanisms of Salmonella pathogenesis and is revealing a picture of the atomic interface between this pathogen and its host. This level of analysis provides the possibility of designing novel therapeutics to disrupt infection and disease processes at the molecular level.
Patel
Jayesh C
JC
Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. jorge.galan@yale.edu
Rossanese
Olivia W
OW
Galán
Jorge E
JE
D000199:Actins / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D015195:Drug Design; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000382:microbiology*; D008840:Microfilament Proteins / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D012475:Salmonella / Q000187:drug effects / Q000201:enzymology / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000378:metabolism / Q000382:microbiology*; D015398:Signal Transduction / Q000187:drug effects; D022161:Transport Vesicles / Q000378:metabolism / Q000382:microbiology; D037521:Virulence Factors / Q000737:chemistry* / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D008840:Microfilament Proteins; C094578:Salmonella invasion protein C; C118287:SipA protein, Salmonella; C419942:Spi1 protein, Salmonella; D037521:Virulence Factors; D017027:Protein Tyrosine Phosphatases; C439890:sptP protein, Salmonella typhimurium; D020741:rho GTP-Binding Proteins