title: A family of putative transcription termination factors shared amongst metazoans and plants.
abstract: The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.
authors.affiliation: Department of Laboratory Medicine, Division for Metabolic Diseases, Karolinska Institutet, Novum, SE-14186, Huddinge, Sweden.
authors.forename: Tomas
authors.initials: T
authors.lastname: Linder
authors.forename: Chan Bae
authors.initials: CB
authors.lastname: Park
authors.forename: Jordi
authors.initials: J
authors.lastname: Asin-Cayuela
authors.forename: Mina
authors.initials: M
authors.lastname: Pellegrini
authors.forename: Nils-Göran
authors.initials: NG
authors.lastname: Larsson
authors.forename: Maria
authors.initials: M
authors.lastname: Falkenberg
authors.forename: Tore
authors.initials: T
authors.lastname: Samuelsson
authors.forename: Claes M
authors.initials: CM
authors.lastname: Gustafsson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000737:chemistry / Q000235:genetics; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008322:Mammals; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D010802:Phylogeny; D010944:Plants / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C105178:MTERF1 protein, human; D024101:Mitochondrial Proteins