[The response of the blood proteins to ablation of the capsaicin-sensitive nerves].
Effects of neurotoxic doses of capsaicin (150 mg/kg) on the protein content in electrophoretic fractions (PAAG) in the Wistar rat plasma were studied. In early period (7 days) after administration of capsaicin, an increase of the alpha1-, alpha2-globulins and a decrease of the albumin, gamma-globulins, were observed. After 14-30 days, increase of the albumin and decrease of the alpha1-, gammay-globulins were detected. The ablation of the capsaicin-sensitive nerves abrogated the changes of positive and negative acute phase reactants induced by zymosan and diminished the content of gamma-globulins.
Kostina
N E
NE
Spiridonov
V K
VK
D000818:Animals; D001797:Blood Protein Electrophoresis / Q000379:methods; D001798:Blood Proteins / Q000032:analysis*; D002211:Capsaicin / Q000633:toxicity*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000139:chemically induced; D008297:Male; D009475:Neurons, Afferent / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D020196:Trauma, Nervous System / Q000097:blood* / Q000139:chemically induced
D001798:Blood Proteins; D002211:Capsaicin