title: Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints.
abstract: OBJECTIVE
  To perform a prospective long term follow up study comparing conventional radiography (CR), ultrasonography (US), and magnetic resonance imaging (MRI) in the detection of bone erosions and synovitis in rheumatoid arthritis (RA) finger joints.
  
  
  METHODS
  The metacarpophalangeal and proximal interphalangeal joints II-V (128 joints) of the clinically dominant hand of 16 patients with RA were included. Follow up joint by joint comparisons for erosions and synovitis were made.
  
  
  RESULTS
  At baseline, CR detected erosions in 5/128 (4%) of all joints, US in 12/128 (9%), and MRI in 34/128 (27%). Seven years later, an increase of joints with erosions was found with CR (26%), US (49%) (p<0.001 each), and MRI (32%, NS). In contrast, joint swelling and tenderness assessed by clinical examination were decreased at follow up (p = 0.2, p<0.001). A significant reduction in synovitis with US and MRI (p<0.001 each) was seen. In CR, 12 patients did not have any erosions at baseline, while in 10/12 patients erosions were detected in 25/96 (26%) joints after 7 years. US initially detected erosions in 9 joints, of which two of these joints with erosions were seen by CR at follow up. MRI initially found 34 erosions, of which 14 (41%) were then detected by CR.
  
  
  CONCLUSIONS
  After 7 years, an increase of bone erosions was detected by all imaging modalities. In contrast, clinical improvement and regression of synovitis were seen only with US and MRI. More than one third of erosions previously detected by MRI were seen by CR 7 years later.
authors.affiliation: Department of Medicine, Nephrology and Rheumatology, Georg-August-University Göttingen, Germany. ascheel@gwdg.de
authors.forename: A K
authors.initials: AK
authors.lastname: Scheel
authors.forename: K-G A
authors.initials: KG
authors.lastname: Hermann
authors.forename: S
authors.initials: S
authors.lastname: Ohrndorf
authors.forename: C
authors.initials: C
authors.lastname: Werner
authors.forename: C
authors.initials: C
authors.lastname: Schirmer
authors.forename: J
authors.initials: J
authors.lastname: Detert
authors.forename: M
authors.initials: M
authors.lastname: Bollow
authors.forename: B
authors.initials: B
authors.lastname: Hamm
authors.forename: G A
authors.initials: GA
authors.lastname: Müller
authors.forename: G R
authors.initials: GR
authors.lastname: Burmester
authors.forename: M
authors.initials: M
authors.lastname: Backhaus
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D013585:Synovitis / Q000175:diagnosis / Q000000981:diagnostic imaging; D014463:Ultrasonography