Lifting the fog in store-operated Ca2+ entry.
Immunoreceptor signalling leads to Ca2+ release from intracellular stores, which is followed by the entry of external Ca2+ into the cell through mysterious store-operated Ca2+ (SOC) channels. Recent studies have identified stromal interaction molecules (STIMs) as having an essential role in SOC influx. Remarkably, Ca2+ store depletion induces a rapid redistribution of the endoplasmic reticulum STIM1 into puncta that accumulate near the plasma membrane. The combined data suggest that STIM1 functions as a Ca2+ sensor in the signalling pathways connecting Ca2+ store depletion to SOC entry.
Dráber
Petr
P
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnská 1083, 142 20 Prague 4, Czech Republic. draberpe@biomed.cas.cz
Dráberová
Lubica
L
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism
D015220:Calcium Channels; D008565:Membrane Proteins; D002118:Calcium