A case of pemphigus vulgaris accompanied by multiple myeloma.
Pemphigus is a mucocutaneous intraepithelial blistering disease caused by autoantibodies to epithelial cell adhesion molecules (desmoglein). The association between pemphigus and malignant neoplasm is well recognized. We present the case of a 62-year-old woman with pemphigus vulgaris accompanied by multiple myeloma. To the best of our knowledge, this is the first report of a case of pemphigus vulgaris concomitant with multiple myeloma. From the results of immunoblotting using normal human epidermal extracts and indirect immunofluorescence using rat bladder sections, and her clinical manifestations, our case does not seem to be one of paraneoplastic pemphigus.
Kurokawa
Motoki
M
Department of Dermatology, Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan. med.miyazaki-u.ac.jp
Koketsu
Hideki
H
Oda
Yujiro
Y
Nagamine
Hidehiro
H
Toyama
Takanori
T
Hashimoto
Takashi
T
Setoyama
Mitsuru
M
D001323:Autoantibodies / Q000097:blood; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D010392:Pemphigus / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D051179:Plakins / Q000097:blood; D011498:Protein Precursors / Q000097:blood
D001323:Autoantibodies; D008565:Membrane Proteins; D051179:Plakins; C110037:Ppl protein, mouse; D011498:Protein Precursors; C100754:envoplakin