Successful treatment of localized cutaneous infection caused by Mycobacterium scrofulaceum with clarithromycin.
Cutaneous infection arising from Mycobacterium scrofulaceum, a nontuberculous mycobacteria, has rarely been reported, and most of the reported infections were disseminated forms in patients with AIDS or other immunocompromising illness. We describe an occurrence of localized mycobacterial skin infection caused by M. scrofulaceum in a previously healthy child that manifested as a red nodule on the cheek. A biopsy specimen of the lesion demonstrated granulomatous infiltration in the dermis. M. scrofulaceum was isolated from culture of a tissue specimen. Polymerase chain reaction amplified specific fragments for M. scrofulaceum. The patient was treated successfully with clarithromycin as monotherapy for 6 months, leading to complete healing without recurrence during a follow-up period of 2 years.
Jang
Ho-Sun
HS
Department of Dermatology, College of Medicine, Pusan National University, Seo-gu, Busan, Korea. hsjang@pusan.ac.kr
Jo
Ju-Hyun
JH
Oh
Chang-Keun
CK
Kim
Moon-Bum
MB
Lee
Jae-Bong
JB
Chang
Chulhun L
CL
Kwon
Yoo-Wook
YW
Kwon
Kyung-Sool
KS
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D017291:Clarithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications / Q000188:drug therapy*; D015359:Mycobacterium scrofulaceum / Q000302:isolation & purification*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D017291:Clarithromycin