title: Interleukin-1alpha production in human corneal scars.
abstract: We studied IL-1alpha level in corneal scars with/without neo-vascularization. A total of 27 patients underwent grafting for corneal scar. Recipients were grouped according to number of vascularized quadrants (0 to IV/IV): none (n = 12), one (n = 5), two (n = 4) and four (n = 6). Recipient corneas were collected during surgery and IL-1alpha measured by immunoassay. Controls were donor corneas unsuitable for transplantation. Graft rejection rate was calculated for each group. Mean IL-1alpha concentration in corneal scars was 6 +/- 3.93 pg/mm3; significantly higher as compared to controls (1.25 +/- 2.03 pg/mm3). IL-1alpha correlated well with amount of blood vessels, except in IV/IV scars: 5.17 +/- 3.65 pg/mm3 for 0/IV; 8.02 +/- 2.51 pg/mm3 for I/IV; 8.27 +/- 3.62 pg/mm3 for II/IV and 4.47 +/- 5.03 pg/mm3 for IV/IV corneal scars. Vascularization of corneal scar is associated with increased IL-1alpha level (in all but highly vascularized scars), indicating that IL-1alpha promotes early stages of vascularization. Graft rejection rate increases in patients with higher vascularization, independently of IL-1alpha level.
authors.affiliation: University Department of Ophthalmology, Lions Croatian Eye Bank, General Hospital, Holy Spirit, Zagreb, Croatia. i.dekaris@eeba.net
authors.forename: Iva
authors.initials: I
authors.lastname: Dekaris
authors.forename: Nikica
authors.initials: N
authors.lastname: Gabrić
authors.forename: Damir
authors.initials: D
authors.lastname: Bosnar
authors.forename: Alenka
authors.initials: A
authors.lastname: Gagro
authors.forename: Alemka
authors.initials: A
authors.lastname: Markotić
authors.forename: Ratimir
authors.initials: R
authors.lastname: Lazić
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002921:Cicatrix / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D003316:Corneal Diseases / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D016510:Corneal Neovascularization / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D016039:Corneal Transplantation; D017523:Croatia / Q000453:epidemiology; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D007375:Interleukin-1