title: Generalized eczema craquele as a presenting feature of systemic lymphoma: report of seven cases.
abstract: Eczema craquele, or asteatotic eczema, has been associated with malignant lymphoma although this is rare. Since 1986, we have observed seven patients, six men and one woman, mean age 71.5 years (range 43-86 years), with systemic lymphoma and concurrent eczema craquele. Five patients had T-cell lymphoma, one had a B-cell lymphoma and one had Hodgkin's disease. All patients shared several characteristics: (1) a synchronous onset of eczema craquele and lymphoma, (2) generalized eczema, (3) absence of alternative disease or conditions that could favour the onset of eczema craquele, and (4) eczema refractory to topical corticosteroids and emollients, but which resolved upon lymphoma remission and invariably recurred with the lymphoma relapse. All the patients except one died within 1 year, most with active lymphoma. The finding of recalcitrant generalized eczema craquele should prompt a search for lymphoma, particularly in older men. Lymphoma-associated eczema craquele has most characteristics of paraneoplastic syndromes and may be a hallmark of aggressive lymphoma.
authors.affiliation: Department of Dermatology, Dupuytren University Hospital, Limoges, France. a.sparsa@free.fr
authors.forename: Agnès
authors.initials: A
authors.lastname: Sparsa
authors.forename: Eric
authors.initials: E
authors.lastname: Liozon
authors.forename: Serge
authors.initials: S
authors.lastname: Boulinguez
authors.forename: Dominique
authors.initials: D
authors.lastname: Bordessoule
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vidal
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Bonnetblanc
authors.forename: Christophe
authors.initials: C
authors.lastname: Bedane
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D004485:Eczema / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications / Q000175:diagnosis* / Q000473:pathology