[Therapeutic options and prognosis of synchronous multiple primary colorectal carcinomas].
OBJECTIVE
To investigate the therapeutic principles and prognosis of synchronous primary colorectal carcinomas (SCC).


METHODS
The data of 66 SCC patients surgically treated from 1984 to 2003 were retrospectively reviewed.


RESULTS
The synchronous primary colorectal carcinomas were diagnosed and resected simultaneously in 65 patients except one that was misdiagnosed. Thirty patients underwent combined resection, 35 patients segmental resection. Sixty-two patients received radical resection, while three patients had palliative resection due to hepatic metastasis. The overall postoperative 3-, 5-, 10-year survival rates were 70.3%, 60.0%, 40.6%, respectively. In the patients who had simultaneous radical resection, the 3-, 5-, 10-year survival rates were 76.0%, 65.9%, 46.4% respectively.


CONCLUSIONS
The extent of resection should be individually determined by the lesion location, extent and distance between the lesions, as well as the patient's general condition. More extensive bowel resection, such as total or subtotal colectomy are suggested for those patients with hereditary nonpolyposis colorectal carcinoma syndrome in order to reduce or avoid the risk of metachronous colorectal carcinoma. The postoperative survival in patients with synchronous primary colorectal carcinoma is similar to those with solitary lesion.
Xu
Li-bin
LB
Department of Abdominal Surgical Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Shao
Yong-fu
YF
Zhao
Dong-bing
DB
Wu
Tie-cheng
TC
Wang
Hai-peng
HP
Zhao
Ping
P
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000601:surgery; D011379:Prognosis; D013274:Stomach Neoplasms / Q000601:surgery; D015996:Survival Rate