title: Staging: relevance for trial design in vascular burden of the brain.
abstract: Cerebrovascular small vessel disease is now believed to be the major source of vascular burden of the brain. Cerebrovascular small vessel disease and Alzheimer's disease appear to represent pathophysiologic and clinical continua, rather than dichotomous entities. It appears that common etiopathologic mechanisms underlie the clinical presentation of both of these conditions. Therefore, the staging procedures that have been developed for the clinical continuum of age-associated memory impairment, mild cognitive impairment, and the progressive dementia of Alzheimer's disease appear to be applicable for the same continua in cerebrovascular small vessel disease. Although temporal and prognostic aspects have been studied for the Alzheimer's-related portions of this clinical staging continuum, they remain to be elucidated for cerebrovascular small vessel disease.
authors.affiliation: William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, NY 10016, USA. barry.reisberg@med.nyu.edu
authors.forename: Barry
authors.initials: B
authors.lastname: Reisberg
authors.forename: Steven H
authors.initials: SH
authors.lastname: Ferris
authors.forename: Thet
authors.initials: T
authors.lastname: Oo
authors.forename: Emile
authors.initials: E
authors.lastname: Franssen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000453:epidemiology*; D003072:Cognition Disorders / Q000175:diagnosis; D017281:Cost of Illness; D005500:Follow-Up Studies; D006801:Humans; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D014805:Vitamin B 12 / Q000378:metabolism
chemical_list: D014805:Vitamin B 12