Androgens and bone growth: it's location, location, location.
Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.
Wiren
Kristine M
KM
Research Service P3 R&D39, VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239-2964, USA. wirenk@ohsu.edu
D000728:Androgens / Q000502:physiology* / Q000627:therapeutic use; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D011944:Receptors, Androgen / Q000502:physiology; D012727:Sex Characteristics
D000728:Androgens; D011944:Receptors, Androgen