Software for quantitative trait analysis.
This paper provides a brief overview of software currently available for the genetic analysis of quantitative traits in humans. Programs that implement variance components, Markov Chain Monte Carlo (MCMC), Haseman-Elston (H-E) and penetrance model-based linkage analyses are discussed, as are programs for measured genotype association analyses and quantitative trait transmission disequilibrium tests. The software compared includes LINKAGE, FASTLINK, PAP, SOLAR, SEGPATH, ACT, Mx, MERLIN, GENEHUNTER, Loki, Mendel, SAGE, QTDT and FBAT. Where possible, the paper provides URLs for acquiring these programs through the internet, details of the platforms for which the software is available and the types of analyses performed.
Almasy
Laura
L
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. almasy@darwin.sfbr.org
Warren
Diane M
DM
D002874:Chromosome Mapping; D006801:Humans; D015810:Linkage Disequilibrium; D040641:Quantitative Trait Loci; D012984:Software