title: Magnetic resonance spectroscopy of memory and frontal brain region in early multiple sclerosis.
abstract: In vivo proton magnetic resonance spectroscopy (1H-MRS) has been used to assess biochemical changes that occur in demyelinating lesions and in normal appearing white matter (NAWM) in multiple sclerosis (MS) patients. N-acetylaspartate (NAA) levels in MS patients may indicate neural viability. In early stages of MS, patients may suffer from slight cognitive impairment. The objective of this study was to investigate memory function in relation to biochemical properties of frontal brain areas of MS patients. Twenty-one patients with relapsing-remitting MS and 21 healthy comparison subjects were examined psychometrically using the Wechsler Memory Scale (WMS) and the Multiple Sclerosis Functional Composite (MSFC) scale, and (1H-MRS) was used to examine frontal deep white matter (left hemisphere) and the frontal cingulate gyrus (Brodmann areas 24/32, bihemispheric). A significant reduction of the NAA/Creatine (Cr) ratio in the frontal cingulate gyrus among the MS patient group was detected when compared to healthy subjects. A significant decrease in the NAA/Cr ratio was also found in volumes of cerebral deep white matter, including plaques, in the MS patients. No NAA/Cr ratio changes were found in NAWM. Differences in MSFC results did not reach statistical significance, but the WMS general memory score showed a significant statistical difference between the patient group and healthy subjects. Regression analysis showed the gray matter NAA/Cr ratio of the frontal cingulate gyrus to be significantly related to distinct memory functions. The authors conclude that (1H-MRS) of gray matter in early stages of MS may be pertinent in the detections of early metabolic disturbances, particularly in subjects with or without minor neurological impairment. Findings suggest a general relationship between the metabolic status of the frontal cortices and memory function.
authors.affiliation: Neurological Department, Christian Doppler Klinik, Ignaz Harrer Strasse 79, 5020 Salzburg, Austria. w.staffen@salk.at
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Staffen
authors.forename: Harald
authors.initials: H
authors.lastname: Zauner
authors.forename: Aldis
authors.initials: A
authors.lastname: Mair
authors.forename: Andrea
authors.initials: A
authors.lastname: Kutzelnigg
authors.forename: Peter
authors.initials: P
authors.lastname: Kapeller
authors.forename: Hilde
authors.initials: H
authors.lastname: Stangl
authors.forename: Edith
authors.initials: E
authors.lastname: Raffer
authors.forename: Helmut
authors.initials: H
authors.lastname: Niederhofer
authors.forename: Gunther
authors.initials: G
authors.lastname: Ladurner
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D004185:Disability Evaluation; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008568:Memory / Q000502:physiology*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010725:Phosphocreatine / Q000378:metabolism; D011522:Protons; D018709:Statistics, Nonparametric
chemical_list: D011522:Protons; D010725:Phosphocreatine; D001224:Aspartic Acid; D002794:Choline