Short-term thyroxine administration leads to lipid peroxidation in renal and testicular tissues of rats with hypothyroidism.
Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.
Mogulkoc
R
R
Department of Physiology, Meram Medical School, Selcuk University, 42080 Konya, Turkey. rasimmogulkoc@yahoo.com
Baltaci
A K
AK
Oztekin
E
E
Ozturk
A
A
Sivrikaya
A
A
D000818:Animals; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D011441:Propylthiouracil / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism*; D013974:Thyroxine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use
D013956:Antithyroid Agents; D008315:Malondialdehyde; D011441:Propylthiouracil; D005978:Glutathione; D013974:Thyroxine