title: Relationship between functional loss before hospital admission and mortality in elderly persons with medical illness.
abstract: OBJECTIVE
  This hospital-based prospective study tests the hypothesis that, in a large group of hospitalized elderly patients, those who report functional decline between pre-illness baseline and hospital admission have a higher risk of death.
  
  
  METHODS
  Nine hundred fifty elderly ambulant patients (F = 69.3%; mean age 78.3 +/- 8.5 years) were consecutively admitted to a geriatric ward (Poliambulanza Hospital, Brescia, Italy) during a 15-month period. Number and severity of somatic diseases, Charlson Index score, APACHE II score, level of serum albumin, cognitive status (by Mini-Mental State Examination), and depression score (by Geriatric Depression Scale), were assessed on admission and evaluated as potential prognostic factors. Functional status (by Barthel Index) was assessed by self-report on admission. Preadmission function was also assessed by self-report at the time of admission. Impairment of function due to an acute event is measured as the difference between performances on admission and 2 weeks before the acute event. Six-month survival was the main outcome variable.
  
  
  RESULTS
  Factors related to mortality in bivariate analysis were: male sex, age over 80, cancer, congestive heart failure, pulmonary diseases, elevated Charlson Index score, and (independently) dementia (Mini-Mental State Examination < 18), APACHE-Acute Physiology Score , albumin level <3.5 g/dL, and anemia. After controlling for these variables and for Barthel Index score 2 weeks before the acute event, change in function due to the acute disease is independently related to 6-month mortality (minor functional change [<30 Barthel Index Point] relative risk: 1.3, 95% confidence interval, 0.6-3.0 and major functional change [major functional decrement] relative risk: 2.8, 95% confidence interval, 1.3-5.7).
  
  
  CONCLUSIONS
  Disease-induced disability may reflect a condition of biological inability to react to acute diseases (i.e., frailty), and should be assessed as a relevant prognostic indicator.
authors.affiliation: Medical Unit for the Acute Care of the Elderly, Poliambulanza Hospital, and Geriatric Research Group, Brescia, Italy. renzo.rozzini@iol.it
authors.forename: Renzo
authors.initials: R
authors.lastname: Rozzini
authors.forename: Tony
authors.initials: T
authors.lastname: Sabatini
authors.forename: Angela
authors.initials: A
authors.lastname: Cassinadri
authors.forename: Stefano
authors.initials: S
authors.lastname: Boffelli
authors.forename: Marco
authors.initials: M
authors.lastname: Ferri
authors.forename: Piera
authors.initials: P
authors.lastname: Barbisoni
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: Marco
authors.initials: M
authors.lastname: Trabucchi
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005260:Female; D016330:Frail Elderly; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends