Direct autoradiographic evidence that rebamipide interacts with neutrophils in dextran sulfate sodium induced colitis in rats.
To determine the effects of rebamipide during the early stages of colitits development, colitis was induced in rats by oral administration of dextran sulfate sodium for 3 or 7 days. The target sites of (3)H-rebamipide were examined by intra-aortic infusion of the radiolabeled compound followed by autoradiography. (3)H-rebamipide was localized in goblet cells in the colon of the control rat, whereas it accumulated in the cytoplasm of mesenchymal cells in dextran sulfate sodium treated rats, localized predominantly to polymorphonuclear leucocytes.
Nakamura
Masahiko
M
Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. nakamuram@pharm.kitasato-u.ac.jp
Takahashi
Tetsufumi
T
Matsumoto
Tsukasa
T
Atsuda
Koichiro
K
Hibi
Norifumi
N
Matsui
Hidenori
H
Yamada
Haruki
H
Tsuchimoto
Kanji
K
D000284:Administration, Oral; D000409:Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D003092:Colitis / Q000503:physiopathology* / Q000517:prevention & control*; D016264:Dextran Sulfate / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D020397:Goblet Cells / Q000737:chemistry; D007202:Indicators and Reagents / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D009504:Neutrophils / Q000737:chemistry; D015363:Quinolones / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D015363:Quinolones; D016264:Dextran Sulfate; C052785:rebamipide; D000409:Alanine