title: Correlation between the resistive index by Doppler ultrasound and kidney function and histology.
abstract: BACKGROUND
  Although duplex Doppler ultrasonography has been used widely, it still is unknown whether resistive index could be related directly to vascular or tubulointerstitial changes in the kidney.
  
  
  METHODS
  Thirty-three patients who underwent renal biopsy were included in the present study. Clinical data, including sex; age; time from abnormal urinalysis result to biopsy; serum creatinine level; creatinine clearance; urinary excretion of protein, N-acetyl-beta-glucosaminidase, and urinary beta2-microglobulin; and presence of hypertension, were recorded at biopsy. Histopathologic data, including glomerular sclerosis, interstitial fibrosis/tubular atrophy, interstitial infiltration, and arteriolosclerosis, were evaluated separately by means of a quantitative or semiquantitative method. We examined whether resistive index at biopsy was related to these clinical and histopathologic parameters and, moreover, to renal outcome in patients followed up for more than 2 years.
  
  
  RESULTS
  Age, creatinine clearance, urinary beta2-microglobulin excretion, and all histopathologic parameters showed statistically significant correlations with resistive index. However, stepwise multiple regression analysis showed that only arteriolosclerosis was chosen as an independent risk factor for increased resistive index. During the follow-up period of 57.5 +/- 15.6 months in 29 patients, 8 patients (27.6%) had progression of renal impairment, defined as an increase in serum creatinine level greater than 50%. They had a significantly increased resistive index at biopsy compared with patients without progression.
  
  
  CONCLUSIONS
  We show a direct relationship between resistive index and arteriolosclerosis in damaged kidneys. Resistive index at renal biopsy may be useful as one of the prognostic markers for renal outcome.
authors.affiliation: Department of Nephrology, Kidney and Dialysis Center, Shonan Kamakura General Hospital, Kanagawa, Saitama, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Ikee
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Noriaki
authors.initials: N
authors.lastname: Hemmi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Imakiire
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Moriya
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Suzuki
authors.forename: Soichiro
authors.initials: S
authors.lastname: Miura
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001160:Arterioles / Q000473:pathology; D001161:Arteriosclerosis / Q000150:complications / Q000000981:diagnostic imaging*; D001284:Atrophy; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005260:Female; D005355:Fibrosis; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007668:Kidney / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology / Q000652:urine; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation; D012598:Sclerosis; D016037:Single-Blind Method; D018616:Ultrasonography, Doppler, Duplex; D014655:Vascular Resistance / Q000187:drug effects; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D000959:Antihypertensive Agents; D001613:beta 2-Microglobulin; D003404:Creatinine; D000118:Acetylglucosaminidase