Cholangiocarcinoma presenting with severe gastroparesis and pseudoachalasia.
Tumor-associated gastroparesis, though reported in association with various malignancies, is rare in patients with cholangiocarcinoma. We report a 55-year-old woman who presented with dysphagia and recurrent vomiting. Esophagogastroduodenoscopy revealed dilated stomach and excess residue without organic obstruction. 99mTc sulfur colloid solid gastric emptying study, radio-opaque marker gut transit study, and esophageal manometry showed features suggestive of gastroparesis and achalasia cardia; electrogastrography revealed bradygastria. Cholangiocarcinoma was detected on CT scan performed after the patient developed jaundice two months later. The lesion was deemed surgically unresectable. She died four months later.
Ghoshal
Uday C
UC
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India. ghoshal@sgpgi.ac.in
Sachdeva
Sanjeev
S
Sharma
Abhinav
A
Gupta
Dinesh
D
Misra
Asha
A
D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004931:Esophageal Achalasia / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D018589:Gastroparesis / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis; D014057:Tomography, X-Ray Computed