title: Constituents of holothuroidea, 16. Determination of Absolute configuration of the branched methyl group in ante-iso type side chain moiety on long chain base of glucocerebroside from the sea cucumber Holothuria leucospilota.
abstract: The absolute configuration of the branched methyl group in ante-iso type side chain moiety on the long chain base of glucocerebroside, HLC-2-A, which was isolated from the sea cucumber Holothuria leucospilota was determined. Oxidation of the glucocerebroside with ozone afforded C13-fragment including the ante-iso moiety. The optically active C13-fragment was synthesized asymmetrically by using the Wittig reaction from chiral synton for comparison with the natural fragment.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Onaka
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masanori
authors.initials: M
authors.lastname: Inagaki
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D005963:Glucosylceramides / Q000737:chemistry* / Q000302:isolation & purification; D047332:Holothuria / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D005963:Glucosylceramides