Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants.
We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8%, IL-6-174GC (n = 605) 9% and IL-6-174CC (n = 167) 12% (P = 0.2 for IL-6-174CC vs GG + GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers (n = 157), 26% of IL-6-174GC-carriers (n = 193) and 27% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.
Göpel
W
W
Department of Pediatrics of the University at Lübeck, Lübeck, Germany. goepel@paedia.ukl.mu-luebeck.de
Härtel
C
C
Ahrens
P
P
König
I
I
Kattner
E
E
Kuhls
E
E
Küster
H
H
Möller
J
J
Müller
D
D
Roth
B
B
Segerer
H
H
Wieg
C
C
Herting
E
E
D001769:Blood / Q000382:microbiology; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D015850:Interleukin-6 / Q000235:genetics*; D007969:Leukomalacia, Periventricular / Q000235:genetics / Q000401:mortality; D008297:Male; D011401:Promoter Regions, Genetic; D018805:Sepsis / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D017287:Ventriculoperitoneal Shunt
D015850:Interleukin-6