[Chronobiological peculiarities of tofisopam action on human heart rate variability].
Repeated administration of the anxiolytic tofisopam (grandaxin) In young male and female human volunteers increases the vagal influence on the parameters of heart rate variability and decreased the level of anxiety. Both effects were more pronounced in the morning than in late daytime and differently expressed in humans with different (morning versus evening) chronotypes.
Arushanian
E B
EB
Baĭda Mastiagina
O A
OA
Mastiagin
S S
SS
Popov
A V
AV
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001569:Benzodiazepines; C012582:tofisopam