Dose-response in stereotactic irradiation of lung tumors.
The dose-response for local tumor control after stereotactic radiotherapy of 92 pulmonary tumors (36 NSCLC and 56 metastases) was evaluated. Short course irradiation of 1-8 fractions with different fraction doses was used. After a median follow-up of 14 months (2-85 months) 11 local recurrences were observed with significant advantage for higher doses. When normalization to a biologically effective dose (BED) is used a dose of 94Gy at the isocenter and 50Gy at the PTV-margin are demonstrated to give 50% probability of tumor control (TCD50). Multivariate analysis revealed the dose at the PTV-margin as the only significant factor for local control.
Wulf
Joern
J
Department of Radiotherapy, University of Wuerzburg, Wuerzburg, Germany.
Baier
Kurt
K
Mueller
Gerd
G
Flentje
Michael P
MP
D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D015999:Multivariate Analysis; D020266:Radiotherapy, Conformal / Q000379:methods*; D016896:Treatment Outcome