title: Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.
abstract: Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biology are described.
authors.affiliation: Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. Zhijian_lu@merck.com
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Lu
authors.forename: Joann
authors.initials: J
authors.lastname: Bohn
authors.forename: Tom
authors.initials: T
authors.lastname: Rano
authors.forename: Carrie A
authors.initials: CA
authors.lastname: Rutkowski
authors.forename: Amy L
authors.initials: AL
authors.lastname: Simcoe
authors.forename: David B
authors.initials: DB
authors.lastname: Olsen
authors.forename: William A
authors.initials: WA
authors.lastname: Schleif
authors.forename: Anthony
authors.initials: A
authors.lastname: Carella
authors.forename: Lori
authors.initials: L
authors.lastname: Gabryelski
authors.forename: Lixia
authors.initials: L
authors.lastname: Jin
authors.forename: Jiunn H
authors.initials: JH
authors.lastname: Lin
authors.forename: Emilio
authors.initials: E
authors.lastname: Emini
authors.forename: Kevin
authors.initials: K
authors.lastname: Chapman
authors.forename: James R
authors.initials: JR
authors.lastname: Tata
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D024882:Drug Resistance, Viral; D006678:HIV / Q000187:drug effects* / Q000201:enzymology; D016333:HIV Protease / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D019469:Indinavir / Q000031:analogs & derivatives*; D015394:Molecular Structure
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir; D016333:HIV Protease