Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: asthenozoospermia.
The aim of aneuploidy evaluation in spermatozoa from patients presenting spermatogenesis defects is to identify a relationship between meiotic errors and quantitative or qualitative alterations of spermatogenesis. During the past ten years, the use of fluorescence in situ hybridization (FISH) has permitted the determination of the frequency of numerical chromosome aberrations in different clinical situations. It has been established that infertile males with reduced sperm count and a normal constitutional karyotype have a significantly high risk of aneuploidy in their spermatozoa particularly regarding sex chromosomes. Concerning sperm motility, the data are more controversial. However, patients of severe asthenozoospermia induced by specific morphological deformities involving sperm flagella have a significantly high risk of producing aneuploid spermatozoa.
Rives
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NM
Laboratoire de Biologie de la Reproduction, Centre Hospitalier Régional, Universitaire Charles Nicolle, Rouen, France. nathalie.rives@chu-rouen.fr
D002869:Chromosome Aberrations; D005407:Flagella / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D012016:Reference Values; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure