title: Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus.
abstract: Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.
authors.affiliation: Rush University Medical Center, Chicago, IL 60612, USA. mhayden@rush.edu
authors.forename: M K
authors.initials: MK
authors.lastname: Hayden
authors.forename: K
authors.initials: K
authors.lastname: Rezai
authors.forename: R A
authors.initials: RA
authors.lastname: Hayes
authors.forename: K
authors.initials: K
authors.lastname: Lolans
authors.forename: J P
authors.initials: JP
authors.lastname: Quinn
authors.forename: R A
authors.initials: RA
authors.lastname: Weinstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000382:microbiology; D017576:Daptomycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000382:microbiology; D008161:Lumbosacral Region / Q000382:microbiology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D010019:Osteomyelitis / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin