title: Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica.
abstract: The inhibitory effects of seven diterpenes, belonging to three different structural classes and isolated from the bark of Xylopia aethiopica, were investigated against the enzymes prolyl endopeptidase (PEP) and alpha-thrombin. Five compounds exhibited inhibitory activity against them.
authors.affiliation: Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, Yaounde, Cameroon.
authors.forename: Noungoue Tchamo
authors.initials: NT
authors.lastname: Diderot
authors.forename: Ngouela
authors.initials: N
authors.lastname: Silvere
authors.forename: Amsha
authors.initials: A
authors.lastname: Yasin
authors.forename: Seema
authors.initials: S
authors.lastname: Zareen
authors.forename: Zelefack
authors.initials: Z
authors.lastname: Fabien
authors.forename: Tsamo
authors.initials: T
authors.lastname: Etienne
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-Ur-Rahman
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000201:enzymology*; D000925:Anticoagulants / Q000737:chemistry / Q000627:therapeutic use*; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000627:therapeutic use*; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D004224:Diterpenes; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases; D013917:Thrombin