title: Different tilting disc valves show similar rotation-dependent impairment in hemodynamic performance under a tilted implantation position.
abstract: BACKGROUND
  Aortic annulus calcification can promote tilted implantation of mechanical valves. This study evaluates the hemodynamics of tilting disc valves under this condition.
  
  
  METHODS
  23 mm and 25 mm Ultracor (UC) and Medtronic-Hall-Easy-Fit (MH) valves were investigated in a pulse-duplicator under physiological conditions. Mean pressure gradient (dP(mean)), systolic energy loss (dW(sys)), effective orifice area (EOA), closure (V(Cl)), leakage (V(L)), and total regurgitation volume (V(R)) were assessed. Valves were independently positioned at five axial rotations (0 - 180 degrees , zero defined as major orifice facing the top of the "tilt-ramp") and three tilt angles (0 degrees, 10 degrees, 20 degrees) by lifting the prosthesis in the noncoronary sinus.
  
  
  RESULTS
  Diameter-enhanced MH valves exhibited a better systolic performance but a higher regurgitation than corresponding UC valves. Moderate tilting showed a rotation-independent increase in dP(mean) and dW(sys) and a decrease in V (R) and EOA with no fundamental differences between valve types. Further tilting caused small additional changes at 90 - 180 degrees rotation. At 0 degrees rotation, however, dramatic regurgitation occurred throughout.
  
  
  CONCLUSIONS
  Tilting worsened systolic performance regardless of valve type. It should therefore be avoided. Due to extensive regurgitation at 0 degrees rotation, this position should be corrected whenever tilting is inevitable.
authors.affiliation: Heart Center Brandenburg, Bernau/Berlin, Germany. m.hartrumpf@immanuel.de
authors.forename: M
authors.initials: M
authors.lastname: Hartrumpf
authors.forename: R U
authors.initials: RU
authors.lastname: Kuehnel
authors.forename: R
authors.initials: R
authors.lastname: Puchner
authors.forename: M O
authors.initials: MO
authors.lastname: Wendt
authors.forename: M
authors.initials: M
authors.lastname: Pohl
authors.forename: J M
authors.initials: JM
authors.lastname: Albes
mesh_terms: D001022:Aortic Valve Insufficiency / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D003971:Diastole / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006350:Heart Valve Prosthesis / Q000145:classification / Q000592:standards*; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D011187:Posture / Q000502:physiology*; D011474:Prosthesis Design / Q000145:classification; D012399:Rotation; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D018667:Tilt-Table Test