title: Successful desensitization of methylphenidate-induced rash.
abstract: OBJECTIVE
  Methylphenidate is a cornerstone of attention-deficit/hyperactivity disorder (ADHD) treatment. Cutaneous adverse reactions resulting from methylphenidate may prohibit its usage. We sought a way to continue this therapy in a patient who developed a rash twice following methylphenidate administration.
  
  
  METHODS
  In a desensitization protocol, methylphenidate was given in increasing doses, 30 minutes apart, over 10 days, until the therapeutic dose was reached and was continued regularly thereafter.
  
  
  RESULTS
  No adverse reactions developed during the desensitization period or during the 6- month follow-up.
  
  
  CONCLUSIONS
  In nonlife threatening cutaneous adverse reactions to methylphenidate, a desensitization protocol may enable the continued, safe administration of this drug.
authors.affiliation: Allergy and Clinical Immunology Unit, Meir General Hospital, Kfar Saba, Israel.
authors.forename: Ronit
authors.initials: R
authors.lastname: Confino-Cohen
authors.forename: Arnon
authors.initials: A
authors.lastname: Goldberg
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000628:therapy*; D005260:Female; D006801:Humans; D008774:Methylphenidate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012882:Skin Tests
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate