Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge hyrtioserectus.
A Red Sea specimen of the marine sponge Hyrtios erectus was found to contain three new alkaloids, hyrtioerectines A-C (1-3). Hyrtioerectine A (1) possesses the carbon bond-linked moieties 6-hydroxy beta-carboline and 6-hydroxyindole. The structure elucidation of 1-3 was based on intensive study of their spectral data including 1D (1H and 13C) and 2D (1H-1H COSY, HOHAHA, NOESY, ROESY, HMQC, and HMBC) NMR, together with high-resolution mass spectra. Hyrtioerectines A-C were moderately cytotoxic.
Youssef
Diaa T A
DT
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. youssefdiaa@hotmail.com
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D019156:Indian Ocean; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C505315:hyrtioerectine A; C505316:hyrtioerectine B; C505317:hyrtioerectine C