Allele and genotype frequencies of CYP2C9 in a Korean population.
OBJECTIVE
To determine the frequencies of the variant alleles and the genotypes of CYP2C9 in a Korean population.


METHODS
Three hundred and fifty-eight healthy Korean subjects were studied. CYP2C9 alleles were detected by polymerase chain reaction-restriction fragment length polymorphism assays and direct sequencing assays.


RESULTS
The allele frequencies were 0.934 for CYP2C9*1, 0.060 for CYP2C9*3 and 0.006 for CYP2C9*13. The CYP2C9*2,*4,*5 and *11 alleles were not detected. The frequencies of the CYP2C9*1/*1, *1/*3 and *1/*13 genotypes were 0.869, 0.120 and 0.011, respectively.


CONCLUSIONS
The frequency of the CYP2C9*3 allele in the Korean population studied was significantly higher than reported elsewhere, and a novel allele, CYP2C9*13, was found at a frequency of 0.006 (95% confidence interval 0, 0.012). Only three genotypes of CYP2C9, CYP2C9*1/*1,*1/*3 and *1/*13 were observed in this Korean population.
Bae
Jung-Woo
JW
Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Kim
Hyun-Kyung
HK
Kim
Ji-Hong
JH
Yang
Sang-In
SI
Kim
Mi-Jeong
MJ
Jang
Choon-Gon
CG
Park
Young-Seo
YS
Lee
Seok-Yong
SY
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases