title: Radiation-induced spinal cord cavernous malformation. Case report.
abstract: The authors report a case of a 16-year-old girl who presented with progressive gait difficulty 8 years after undergoing spinal radiation therapy for spinal astrocytoma. Magnetic resonance imaging revealed intramedullary multicentric cavity formation in the T4-10 area. Extensive subtotal resection was performed and a pathological examination of the excised tissue demonstrated cavernous malformation with radiation-induced degeneration in the surrounding vessels. This is believed to be the third case of de novo formation of an intramedullary cavernous malformation following spinal radiation therapy.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshino
authors.forename: Akio
authors.initials: A
authors.lastname: Morita
authors.forename: Junji
authors.initials: J
authors.lastname: Shibahara
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kirino
mesh_terms: D000293:Adolescent; D001165:Arteriovenous Malformations / Q000209:etiology*; D001254:Astrocytoma / Q000532:radiotherapy; D005260:Female; D006801:Humans; D011832:Radiation Injuries / Q000473:pathology*; D013118:Spinal Cord Diseases / Q000209:etiology*; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy; D013997:Time Factors