title: Synthesis of N-substituted aminoalkyl derivatives of some epoxyisoindoles as potential pharmacological agents.
abstract: Grogan and Rice reported a number of imides of epoxyisoindole sort. Some pharmacological testing was performed which revealed their bioactivity. Except of their work, only scattered examples of derivatives with oxygen-bridged ring have appeared in the literature; this approach has also been used by us in the synthesis of some new potential drugs. This paper reports the synthesis of a number of epoxyisoindole derivatives, as well as in vitro tests of some selected representants.
authors.affiliation: Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kossakowski
authors.forename: Aldona
authors.initials: A
authors.lastname: Raszkiewicz
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents