title: Oxidation of liposomal membrane suppressed by flavonoids: quantitative structure-activity relationship.
abstract: Antioxidant activity of the set of 12 flavonoids in heterogeneous membrane system of dioleoyl phosphatidylcholine liposomes stressed by peroxidative damage induced by 2,2'-azobis-(2-amidinopropane)hydrochloride azoiniciator and evaluated by the thiocyanate method was assessed. Antioxidant activity (pIC(50)) was correlated with 19 molecule parameters calculated for the minimum energy conformers of the compounds tested. The linear regression analysis revealed that the parameter of hydration energy E(HYDR) (R = -0.747) was the best predictor of antioxidant activity in a liposomal system.
authors.affiliation: Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava. exfadada@savba.sk
authors.forename: Lucia
authors.initials: L
authors.lastname: Rackova
authors.forename: Silvia
authors.initials: S
authors.lastname: Firakova
authors.forename: Daniela
authors.initials: D
authors.lastname: Kostalova
authors.forename: Milan
authors.initials: M
authors.lastname: Stefek
authors.forename: Ernest
authors.initials: E
authors.lastname: Sturdik
authors.forename: Magdalena
authors.initials: M
authors.lastname: Majekova
mesh_terms: D005419:Flavonoids / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D021281:Quantitative Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D008081:Liposomes