[Clinical observation of Gingko biloba extract injection in treating early diabetic nephropathy].
OBJECTIVE
To observe the effect of Ginkgo biloba extract injection (GB) in treating early diabetic nephropathy (DN).


METHODS
Sixty DN patients were divided into two groups, the treated group were treated by GB and Western medicine, and the control group were given Western medicine alone. The study lasted for 4 weeks. Fasting plasma glucose (FPG), blood pressure, 24 h urinary albumin excretion (UAE), endogenous creatinine clearance rate (Ccr), blood lipids and hemorheology indices were examined before and after the study.


RESULTS
Compared with the control group, UAE were significantly decreased (P < 0.01); Ccr, blood lipids and hemorheology indices were all improved after treatment in the treated group (P < 0.05 or P < 0.01). But in FPG and blood pressure there was no significant change between the treated group and the control group (P > 0.05).


CONCLUSIONS
GB is effective in treating early DN through decreasing urinary albumin excretion rate, regulating blood lipids, improving renal function and hemorheology.
Lu
Jie
J
Department of Nephrology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
He
Hai
H
D000368:Aged; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D005260:Female; D020441:Ginkgo biloba; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D016896:Treatment Outcome
D010936:Plant Extracts