Systemic lupus erythematosus due to Epstein-Barr virus or Epstein-Barr virus infection provocating acute exacerbation of systemic lupus erythematosus?
Systemic lupus erythematosus (SLE) is a rheumatologic disease characterized by an inflammatory destruction of the target organ systems of the body in an unknown way by autoantibodies formed against self-antigens. Infectious agents like Epstein-Barr virus (EBV), cytomegalovirus and parvovirus B19 may have a role in the occurrence or the exacerbation of the SLE. In this report, the clinical follow-up of a 14-year-old girl diagnosed with SLE following an EBV infection with bicytopenia, lymphadenomegaly and hepatomegaly is discussed. This case could support the role of viral infections in the etiology of SLE.
Kasapcopur
Ozgur
O
Department of Pediatrics, Division of Rheumatology and Infectious Diseases, Cerrahpasa Medical Faculty, Istanbul University, Ataköy 4. Kisim, 0-117/4 34750, Istanbul, Turkey. ozgurcopur@e-kolay.net
Ergul
Yakup
Y
Kutlug
Seyhan
S
Candan
Cengiz
C
Camcioglu
Yildiz
Y
Arisoy
Nil
N
D000293:Adolescent; D001327:Autoimmune Diseases / Q000821:virology; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000473:pathology* / Q000628:therapy / Q000821:virology*; D013997:Time Factors; D016896:Treatment Outcome
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide