Modelling in the study of interaction of Hemopump device and artificial ventilation.
The aim of this work is to evaluate in different ventricular conditions the influence of joint mechanical ventilation (MV) and Hemopump assistance. To perform this study, we used a computer simulator of human cardiovascular system where the influence of MV was introduced changing thoracic pressure to positive values. The simulation confirmed that haemodynamic variables are highly sensitive to thoracic pressure changes. On the other hand, Hemopump assistance raises, among the others, mean aortic pressure, total cardiac output (left ventricular output flow plus Hemopump flow) and coronary flow. The simulation showed that the joint action of Hemopump and positive thoracic pressure diminishes these effects.
De Lazzari
C
C
C.N.R., Institute of Clinical Physiology, Cardiovascular Engineering Department, Viale dell' Universitá, 11 00185, Rome Section, Italy. dela@ifc.cnr.it
Darowski
M
M
Ferrari
G
G
Pisanelli
D M
DM
Tosti
G
G
D000399:Air Pressure; D016280:Atrial Function, Right / Q000502:physiology; D001775:Blood Circulation / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology; D006353:Heart-Assist Devices; D006801:Humans; D008432:Mathematical Computing; D008955:Models, Cardiovascular; D011652:Pulmonary Circulation / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012121:Respiration, Artificial; D012984:Software; D013318:Stroke Volume / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D014690:Venous Pressure / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology