title: Effects of changes to the stable environment on the exhalation of ethane, carbon monoxide and hydrogen peroxide by horses with respiratory inflammation.
abstract: The aim of this study was to assess the effects of changes to the stable environment on exhaled markers of respiratory inflammation in six horses with clinical histories of recurrent airway obstruction. The horses were maintained for two weeks under conventional stable management (straw bedding and hay) and for two weeks on a reduced-dust regimen (paper bedding and ensiled grass), in a crossover study design. Exhaled ethane and carbon monoxide (CO) and exhaled breath condensate hydrogen peroxide (H(2)O(2)) were measured every three days under each regimen. The presence of clinical signs of airway inflammation (nasal discharge and cough) was monitored daily. The reduced-dust regimen was associated with fewer clinical signs of airway inflammation than the conventional regimen. Exhaled ethane and CO were significantly lower on the reduced-dust regimen and these markers were correlated with clinical signs of respiratory inflammation, but exhaled H(2)O(2) was not affected by the management regimen.
authors.affiliation: Division of Companion Animal Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden, Glasgow G61 1QH, Scotland, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Wyse
authors.forename: K
authors.initials: K
authors.lastname: Skeldon
authors.forename: J W
authors.initials: JW
authors.lastname: Hotchkiss
authors.forename: G
authors.initials: G
authors.lastname: Gibson
authors.forename: P S
authors.initials: PS
authors.lastname: Yam
authors.forename: R M
authors.initials: RM
authors.lastname: Christley
authors.forename: T
authors.initials: T
authors.lastname: Preston
authors.forename: D R S
authors.initials: DR
authors.lastname: Cumming
authors.forename: M
authors.initials: M
authors.lastname: Padgett
authors.forename: J C
authors.initials: JC
authors.lastname: Cooper
authors.forename: S
authors.initials: S
authors.lastname: Love
mesh_terms: D000402:Airway Obstruction / Q000453:epidemiology / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D001944:Breath Tests; D002248:Carbon Monoxide / Q000032:analysis*; D018592:Cross-Over Studies; D004391:Dust; D004777:Environment; D004980:Ethane / Q000032:analysis*; D006734:Horse Diseases / Q000453:epidemiology / Q000378:metabolism*; D006736:Horses; D006799:Housing, Animal; D006861:Hydrogen Peroxide / Q000032:analysis*; D012008:Recurrence
chemical_list: D004391:Dust; D002248:Carbon Monoxide; D006861:Hydrogen Peroxide; D004980:Ethane