Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis.
To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), beta-funaltrexamine (beta-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (kappa-receptor antagonist) and beta-FNA (mu-receptor antagonist), while NTI (delta-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of mu-, kappa-receptors and adenosine-receptor.
Chi
Yu-Ming
YM
Seiwa Pharmaceutical, Ltd; 187-11 Usuba, Hanakawa-machi, Kitaibaraki, Ibaraki 319-1535, Japan. chi-59@unimatec.co.jp
Nakamura
Motoyuki
M
Yoshizawa
Toyokichi
T
Zhao
Xi-Ying
XY
Yan
Wen-Mei
WM
Hashimoto
Fumio
F
Kinjo
Junei
J
Nohara
Toshihiro
T
Sakurada
Shinobu
S
D000470:Alkaloids / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D039821:Monoterpenes / Q000494:pharmacology*; D009271:Naltrexone / Q000008:administration & dosage / Q000031:analogs & derivatives; D009292:Narcotic Antagonists; D058915:Purinergic P1 Receptor Antagonists
D000470:Alkaloids; D000700:Analgesics; D039821:Monoterpenes; D009292:Narcotic Antagonists; D058915:Purinergic P1 Receptor Antagonists; C400141:incarvillateine; C051844:norbinaltorphimine; D009271:Naltrexone; C024524:beta-funaltrexamine; C055382:naltrindole