title: Doxorubicin-encapsulated thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): drug release behavior and stability in the presence of serum.
abstract: In the field of the temperature sensitive drug delivery systems, we studied on the surface modification of liposomes by using poly(N-isopropylacrylamide-co-acrylamide) (PNIPAM-AAM) and polyethyleneglycol (PEG) to increase the release of doxorubicin (DOX) from liposomes and prolong the stability of liposomes in the presence of serum. The release of DOX from the PNIPAM-AAM/PEG modified liposomes is enhanced around the transition temperature of the polymer. In addition, the stability of the PNIPAM-AAM/PEG modified liposomes in serum shows a high level comparing with polymer unmodified liposomes. These results suggest that the modification on the surface of liposomes with both PNIPAM-AAM and PEG enhances the drug release from liposomes and reduces the protein adsorption in serum.
authors.affiliation: Advanced Materials Division, Korea Research Institute of Chemical Technology, Daejeon, South Korea.
authors.forename: Hee Dong
authors.initials: HD
authors.lastname: Han
authors.forename: Byung Cheol
authors.initials: BC
authors.lastname: Shin
authors.forename: Ho Suk
authors.initials: HS
authors.lastname: Choi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D004355:Drug Stability; D008081:Liposomes / Q000138:chemical synthesis / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011485:Protein Binding; D044967:Serum / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D008081:Liposomes; C469412:poly(N-isopropylacrylamide-co-acrylamide); D011092:Polyethylene Glycols; D004317:Doxorubicin