Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M.
Lysozyme is a ubiquitous and abundant, cationic, antimicrobial polypeptide of leukocytes and epithelia, but its biological function in host defense is largely unexplored. To ascertain the role of lysozyme during bacterial infection of murine airways, we exposed the airways of lysozyme M-deficient (lys M-/-) mice to the pulmonary pathogen Pseudomonas aeruginosa and examined the host's response to infection. Despite partial compensation as a result of the appearance of lysozyme P in the infected airways of lys M-/- mice, these lys M-/- mice showed decreased clearance of P. aeruginosa compared with their lys M+/- or lys M+/+ littermates. Lysozyme contributes to optimal clearance of P. aeruginosa from the murine airways.
Cole
Alexander M
AM
Department of Molecular Biology and Microbiology, Biomolecular Science Center, University of Central Florida, Orlando 32816, USA. acole@mail.ucf.edu
Thapa
Dharma R
DR
Gabayan
Victoria
V
Liao
Hsiang-I
HI
Liu
Lide
L
Ganz
Tomas
T
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D008168:Lung / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009079:Mucociliary Clearance / Q000276:immunology*; D009113:Muramidase / Q000172:deficiency* / Q000235:genetics / Q000276:immunology*; D011552:Pseudomonas Infections / Q000276:immunology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000276:immunology* / Q000472:pathogenicity
D009113:Muramidase; C472450:lysozyme M, mouse; C472773:lysozyme P, mouse