title: The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats.
abstract: We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.
  
  
  CONCLUSIONS
  Effective perioperative pain management can improve postoperative recovery. We studied the effects of two preoperative pain management techniques on recovery after laparotomy in rats. Both analgesic treatments resulted in a faster recovery, especially preoperative analgesics combined with interleukin-1 receptor antagonist.
authors.affiliation: *Department of Psychology, Hebrew University, Jerusalem; and †Department of Anesthesiology, Rabin Medical Center, Golda-Hasharon Campus, Petah Tiqva, affiliated with the Sackler School of Medicine, Tel-Aviv University, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shavit
authors.forename: Gila
authors.initials: G
authors.lastname: Fish
authors.forename: Gilly
authors.initials: G
authors.lastname: Wolf
authors.forename: Eduard
authors.initials: E
authors.lastname: Mayburd
authors.forename: Ylia
authors.initials: Y
authors.lastname: Meerson
authors.forename: Raz
authors.initials: R
authors.lastname: Yirmiya
authors.forename: Benzion
authors.initials: B
authors.lastname: Beilin
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002045:Bupivacaine / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004435:Eating / Q000187:drug effects*; D053590:Interleukin 1 Receptor Antagonist Protein; D007813:Laparotomy; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344; D012795:Sialoglycoproteins / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D053590:Interleukin 1 Receptor Antagonist Protein; D012795:Sialoglycoproteins; D009020:Morphine; D002045:Bupivacaine