Novel synthesis of 2-aryl and 2,3-disubstituted indoles by modified double elimination protocol.
[reaction: see text] Syntheses of 2-aryl and 2,3-substituted indoles were realized by modified double elimination protocol. Under basic conditions, vinyl sulfones derived from the reaction of 2-aminobenzyl sulfone with benzaldehydes underwent cyclization and alkylation followed by elimination of sulfinic acid to afford 2,3-substituted indoles.
Babu
Govindarajulu
G
Department of Applied Chemistry, Okayama University of Science, Ridai-cho, Okayama 700-0005, Japan.
Orita
Akihiro
A
Otera
Junzo
J
D000478:Alkylation; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013450:Sulfones / Q000737:chemistry
D006571:Heterocyclic Compounds; D007211:Indoles; D013450:Sulfones; C009873:divinyl sulfone