Synthesis and antiviral activity of novel chiral cyanoacrylate derivatives.
2-Cyanoacrylate is an important kind of herbicide targeted in photosystem II. Starting from cyano ethyl acetate, the chiral title compounds were synthesized under microwave irradiation, which has the advantages of shorter reaction time, higher yield, and simpler procedure. A half-leaf method was used to determine the inhibition and curative efficacies of the eight chiral products against tobacco mosaic virus in vivo. It was found that chiral compound IIc-R possesses moderate inhibition and curative effect in vivo with rates of 89.1 and 43.1%, respectively. In the MTT test, these new chiral compounds were found to possess weak antiproliferation activities to PC3 and A431 cells.
Song
Baoan
B
Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, People's Republic of China. songbaoan22@yahoo.com
Zhang
Huiping
H
Wang
Hua
H
Yang
Song
S
Jin
Linhong
L
Hu
Deyu
D
Pang
Lili
L
Xue
Wei
W
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003460:Crystallization; D003487:Cyanoacrylates / Q000138:chemical synthesis* / Q000494:pharmacology*; D006540:Herbicides / Q000494:pharmacology; D008872:Microwaves; D008958:Models, Molecular; D015394:Molecular Structure; D014027:Tobacco Mosaic Virus / Q000187:drug effects
D000998:Antiviral Agents; D003487:Cyanoacrylates; D006540:Herbicides