Hepatitis-associated aplastic anemia: successful outcome following immunosuppressive therapy.
Hepatitis-associated aplastic anemia is an uncommon variant seen in young, previously healthy individuals. The pancytopenia follows hepatitis by a few weeks and is usually severe and prolonged. Bone marrow transplantation remains the cornerstone of therapy. However, immunosuppressive therapy has been found to be effective. We report an 8-year-old girl who had non-A, B, C and E hepatitis-associated severe aplastic anemia. She became transfusion-independent and had consistent, albeit incomplete recovery after immunosuppressive therapy with antithymocyte globulin and cyclosporine.
Gupta
Anju
A
Division of Pediatric Hematology-Oncology, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.
Bansal
Deepak
D
Marwaha
R K
RK
Trehan
Amita
A
D000741:Anemia, Aplastic / Q000821:virology*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents