CYP3A4 inhibitors isolated from Licorice.
The extract of licorice (Glycyrrhiza uralensis FISHER, Leguminosae) showed CYP3A4 inhibitory activity with the IC50 value of 0.022 mg/ml. Bioassay-guided purification afforded nine compounds, 3-(p-hydroxyphenyl)propionic acid (1), isoliquiritigenin (2), (3R)-vestitol (3), licopyranocoumarin (4), 4-hydroxyguaiacol apioglucoside (5), liquiritin (6), liquiritigenin 7,4'-diglucoside (7), liquiritin apioside (8), and glucoliquiritin apioside (9). Among these compounds, 3, 7, and 5 showed potent CYP3A4 inhibitory activities with IC50 values of 3.6, 17, and 20 microM, respectively. Glycyrrhizin (10), a main constituent of licorice, however, was inactive for CYP3A4 inhibition.
Tsukamoto
Sachiko
S
Graduate School of Natural Science and Technology, Kanazawa University; Kakuma-machi, Kanazawa 920-1192, Japan.
Aburatani
Maki
M
Yoshida
Tomohiro
T
Yamashita
Yuko
Y
El-Beih
Ahmed Atef
AA
Ohta
Tomihisa
T
D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006035:Glycyrrhiza / Q000737:chemistry*; D006801:Humans
D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors