title: [Cytogenetic changes in cells of mammals after irradiation by protons with an energy of 1000 MeV and gamma-rays 137CS].
abstract: The purpose was to investigate cytological and cytogenetic disorders in cornea epithelium and bone marrow cells of mice after different periods since irradiation by protons at an energy of 1000 MeV and gamma doses of 25 to 400 cGy (137Cs). Suppression of the mitotic activity of cells by ionizing radiations was a function of dose value. In addition, the rate of aberrant mitoses was dependent on the type of radiation and time elapsed after exposure. Coeffcients of the relative biological effectiveness of protons with an energy of 1000 MeV in 24, 72 and 120 hrs. after irradiation were calculated based on comparison of doses compromising mitosis in 50% of differentiating cells. For the cornea epithelium cell the coefficients amounted to 1.3; 1.2 and 1.1, respectively; for the bone marrow cells they were 1.2; 1.1 and 0.9, respectively. The fingerprint of the proton biological effect is a higher production of exchange aberrations suggesting more severe damages to the hereditary cells.
authors.forename: S V
authors.initials: SV
authors.lastname: Vorozhtsova
authors.forename: D V
authors.initials: DV
authors.lastname: Rakov
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000528:radiation effects*; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008938:Mitosis; D009678:Nuclear Energy; D011522:Protons / Q000009:adverse effects*
chemical_list: D011522:Protons