title: Long-term reduction of atrial tachyarrhythmia recurrences in patients paced for bradycardia-tachycardia syndrome.
abstract: BACKGROUND
  Atrial tachyarrhythmias (AT) are considered progressive diseases. Several rhythm control therapies for treatment of AT have been proposed.
  
  
  OBJECTIVE
  The Italian AT500 Registry was designed to prospectively study long-term AT evolution in patients paced for the brady-tachy form of sinus node disease (BT-SND).
  
  
  METHODS
  Three hundred forty-six BT-SND patients received an antitachycardia dual-chamber pacemaker and were followed-up for a minimum of 12 months (median 19 months). Prevention and antitachycardia pacing (ATP) features were enabled in all patients.
  
  
  RESULTS
  During the observation period, 224 (65%) patients were treated by antiarrhythmic drugs and 45 (13%) patients were cardioverted. Five patients suffered a stroke, 4 transient ischemic attack, 22 permanent AT, and 98 AT recurrences longer than 7 days. AT mean cycle length changed from 246 to 270 ms, and the percentage of patients with AT-related hospitalizations significantly decreased with an annual 28% relative reduction. AT burden and the percentage of patients with AT recurrences longer than 2 days remained constant with time in the overall population but decreased significantly in the subgroup of patients who did not develop permanent AT. High ATP efficacy was associated with an increasingly higher prevention of AT recurrences longer than 2 days.
  
  
  CONCLUSIONS
  In a long-term observation of BT-SND patients, AT-related hospitalizations decreased significantly and mean AT cycle length increased significantly. The data suggest that rhythm control therapies induce inversion of AT progression.
authors.affiliation: Institute of Internal Medicine and Cardiology, University of Florence, Florence, Italy. lpadeletti@interfree.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Padeletti
authors.forename: Massimo
authors.initials: M
authors.lastname: Santini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Boriani
authors.forename: Gianluca
authors.initials: G
authors.lastname: Botto
authors.forename: Michele
authors.initials: M
authors.lastname: Gulizia
authors.forename: Giulio
authors.initials: G
authors.lastname: Molon
authors.forename: Gianni
authors.initials: G
authors.lastname: Luzzi
authors.forename: Gaetano
authors.initials: G
authors.lastname: Senatore
authors.forename: Francesco
authors.initials: F
authors.lastname: Giraldi
authors.forename: Francesco
authors.initials: F
authors.lastname: Zolezzi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pieragnoli
authors.forename: Francesco
authors.initials: F
authors.lastname: Pro
authors.forename: Tiziana
authors.initials: T
authors.lastname: Desanto
authors.forename: Andrea
authors.initials: A
authors.lastname: Grammatico
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001919:Bradycardia / Q000503:physiopathology / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D004554:Electric Countershock; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D010343:Patient Admission; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies; D012008:Recurrence; D012804:Sick Sinus Syndrome / Q000503:physiopathology / Q000628:therapy; D013577:Syndrome; D013610:Tachycardia / Q000503:physiopathology / Q000628:therapy; D013612:Tachycardia, Ectopic Atrial / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents