[Alterations of procalcitonin and interleukin 6 after cardiopulmonary bypass in children with congenital heart disease].
Cardiac surgery induces systemic inflammatory response that may have been implicated the postoperative organ dysfunction. This inflammatory response is thought to be produced by exposing patients to proinflammatory factors. The aim of our study was to investigate alterations in procalcitonin (PCT) concentration in peripheral blood in children as the potential early indicator of complications occurring during and after surgery in extracorporeal circulation. Additionally, we evaluated the perioperative time course of IL-6.


METHODS
The investigations were carried out in 21 children undergoing cardiac operation with cardiopulmonary bypass (CPB). Serum concentrations of PCT and IL-6 were sequentially measured before induction of anesthesia, at the initiation of CPB, at the end of CPB, and 24 hours, and 72 hours after CPB.


RESULTS
There was no significant PCT-elevation at all 5 times of measurement. Levels of IL-6 increased significantly after surgery, and remained elevated for up to 1 day. Peak values correlated with the duration of CPB (r=0.68, p=0.0006).


CONCLUSIONS
We conclude, that cardiac surgery with CPB did not have any influence on the secretion of PCT in children. These results suggest that IL-6 was more effective than PCT to monitor patients with a favorable outcome.
Paśnik
Jarosław
J
Klinika Pediatrii, Kardiologii Prewencyjnej i Immunologii Wieku Rozwojowego Instytutu Pediatrii Uniwersytetu Medycznego w Lodzi. elute@poczta.onet.pl
Moll
Jadwiga Anna
JA
Moll
Jacek
J
Cywińska-Bernas
Agnieszka
A
Mazurowski
Wojciech
W
Arendarczyk
Jerzy
J
Sysa
Andrzej
A
Banasik
Małgorzata
M
Zeman
Krzysztof
K
D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011498:Protein Precursors / Q000097:blood*; D013997:Time Factors
C000606589:CALCA protein, human; D015850:Interleukin-6; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide