Polyketide stereotetrads in natural products.
Natural products (or secondary metabolites) remain as the most important source for discovery of new and potential drug molecules. With high resolution data of their structures, and the advancement of synthesis possibilities, analysis of the natural products based on their specific structural features is valuable to those entering the field. In this tutorial review we attempt such an analysis indicating the salient features of the structural classes with examples of the synthesis of each one of them. As the particular class of natural products, we have chosen polyketides.
Koskinen
Ari M P
AM
Laboratory of Organic Chemistry, Helsinki University of Technology, PO Box 6100, FIN-02015 TKK, Finland. ari.koskinen@hut.fi
Karisalmi
Kaisa
K
D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry*; D013237:Stereoisomerism
D005231:Fatty Acids, Unsaturated; D018942:Macrolides; D010936:Plant Extracts; C505374:pteroenone