Penetration of piperacillin and tazobactam into inflamed soft tissue of patients with diabetic foot infection.
We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.
Legat
F J
FJ
Department of Dermatology, Division of Infectious Diseases, Medical University of Graz, Austria. franz.legat@meduni-graz.at
Krause
R
R
Zenahlik
P
P
Hoffmann
C
C
Scholz
S
S
Salmhofer
W
W
Tscherpel
J
J
Tscherpel
T
T
Kerl
H
H
Dittrich
P
P
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D017719:Diabetic Foot / Q000378:metabolism*; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000473:pathology; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D010878:Piperacillin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018461:Soft Tissue Infections / Q000378:metabolism*; D000078142:Tazobactam
D000900:Anti-Bacterial Agents; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin