[Age-dependent effects of flavonoids on secretory function of the rat liver].
The effects of the chamomilla recutita (1) flavonoids (chamiloflan) on bilegenesis of the adult and old white rats were investigated. Chamiloflan (20, 40 and 80 mg/kg) induced a dose-dependent increase in the bile flow and bile acid secretion in rats of both age groups. Cholesterol concentration in the liver and bile cholesterol secretion were not changed in the treated adult rats. Chamiloflan increased cholesterol bile secretion and reduced lipid content in the liver of the old rats.
Babenko
N O
NO
Shakhova
O H
OH
D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D031168:Matricaria / Q000737:chemistry*; D051381:Rats
D001647:Bile Acids and Salts; D005419:Flavonoids; D002784:Cholesterol