title: Sweet's syndrome--an extraintestinal manifestation in inflammatory bowel disease.
abstract: OBJECTIVE
  Sweet's syndrome (SS) is a severe dermatosis that may be an extraintestinal manifestation of inflammatory bowel disease (IBD). Worldwide, 35 cases of SS associated with IBD have been reported. We present the first case of severe, recurrent SS in combination with amebic infection and ulcerative colitis complicated with multiple other extraintestinal manifestations.
  
  
  METHODS
  Disease course was monitored by serum YKL-40 and C-reactive protein (CRP), white blood cell count, albumin and the Simple Clinical Colitis Activity Index (SSCAI). The amebic infection was diagnosed by direct microscopy of wet mount scrapings sampled by repetitive sigmoidoscopies.
  
  
  RESULTS
  The patient was diagnosed with left-sided ulcerative colitis and SS combined with extraintestinal manifestations: arthropathies, iridocyclitis and erythema nodosum. Cysts of Entamoeba histolytica were detected in the stools in two separate periods of time. Serum YKL-40 increased prior to CRP and correlated with disease activity, SCCAI, CRP, white blood cell count and inversely with serum albumin.
  
  
  CONCLUSIONS
  This case gives further support for SS being an extraintestinal manifestation of ulcerative colitis. YKL-40 may be useful in monitoring the disease course of IBD.
authors.affiliation: Department of Medical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark. ytting@dadlnet.dk
authors.forename: Henriette
authors.initials: H
authors.lastname: Ytting
authors.forename: Ida
authors.initials: I
authors.lastname: Vind
authors.forename: Didi
authors.initials: D
authors.lastname: Bang
authors.forename: Pia
authors.initials: P
authors.lastname: Munkholm
mesh_terms: D054392:Adipokines; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D000071451:Chitinase-3-Like Protein 1; D003937:Diagnosis, Differential; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D037102:Lectins; D011247:Pregnancy; D016463:Sweet Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D054392:Adipokines; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins; D002097:C-Reactive Protein