One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.
[reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.
Mohamed Ahmed
Mohamed S
MS
Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259 Nagatsuta, Yokohama 226-8503, Japan.
Kobayashi
Kei
K
Mori
Atsunori
A
D002384:Catalysis; D006830:Hydralazine / Q000737:chemistry; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
D007555:Isoxazoles; D011720:Pyrazoles; D006830:Hydralazine; C031280:pyrazole; D010165:Palladium