title: Collie eye anomaly in a mixed-breed dog.
abstract: A 5-year-old, mixed-breed dog was presented for tetraparesis. Neurologic alterations included a decreased menace response in both eyes. Therefore, an ophthalmic examination was requested. The dog was visual, but menace response, dazzle and pupillary light reflexes were reduced bilaterally. Indirect ophthalmoscopy revealed bilateral optic nerve coloboma and severe choroidal hypoplasia. These lesions closely resembled the ophthalmoscopic features of Collie eye anomaly (CEA). In spite of treatment, the dog's condition worsened and the animal was therefore euthanized. Histology of the globes confirmed severe choroidal hypoplasia and optic disc coloboma in both eyes. The dog was diagnosed to have a lymphoma involving the spinal cord. The two entities were considered not related. As only moderate sight impairment was caused by the posterior segment anomalies, it is by chance that these lesions resembling CEA were found in this mixed-breed dog.
authors.affiliation: Department of Animal Pathology, College of Veterinary Medicine, University of Torino, 10095 Grugliasco, Italy. antonella.rampazzo@unito.it
authors.forename: Antonella
authors.initials: A
authors.lastname: Rampazzo
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Angelo
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Capucchio
authors.forename: Sandra
authors.initials: S
authors.lastname: Sereno
authors.forename: Claudio
authors.initials: C
authors.lastname: Peruccio
mesh_terms: D000818:Animals; D002829:Choroid / Q000002:abnormalities*; D003103:Coloboma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005124:Eye Abnormalities / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005654:Fundus Oculi; D008223:Lymphoma / Q000150:complications / Q000662:veterinary; D009900:Optic Nerve / Q000002:abnormalities*; D011782:Quadriplegia / Q000209:etiology / Q000662:veterinary; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000662:veterinary