Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors.
An examination of several amine-substituted analogs of N(1)-benzenesulfonylindoles reveals that although they bind at human 5-HT(6) serotonin receptors with high affinity, they are likely to bind in a dissimilar manner.
Pullagurla
Manik
M
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
Siripurapu
Uma
U
Kolanos
Renata
R
Bondarev
Mikhail L
ML
Dukat
Małgorzata
M
Setola
V
V
Roth
B L
BL
Glennon
Richard A
RA
D000588:Amines / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000737:chemistry*
D000588:Amines; D007211:Indoles; D011985:Receptors, Serotonin; C097216:serotonin 6 receptor