A new SUMO ligase in the DNA damage response.
SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.
Lee
Karen M
KM
Department of Oncological Sciences, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.
O'Connell
Matthew J
MJ
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D025842:SUMO-1 Protein / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C486627:SMC5 protein, S cerevisiae; C486631:SMC6 protein, S cerevisiae; D025842:SUMO-1 Protein; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C486628:Smc5 protein, S pombe; C486630:smc6 protein, S pombe