title: Subacute cutaneous lupus erythematosus: a paraneoplastic dermatosis?
abstract: Subacute cutaneous lupus erythematosus (SCLE) is characterized by clinical, laboratory and immunological features different from those of systemic lupus erythematosus (SLE). We describe the case of a patient with a 2-year history of SCLE that demonstrated a close temporal relationship with a squamous cell malignancy of the head and neck. This association has not been previously reported. We also review the evidence for SCLE as a 'paraneoplastic dermatosis' and discuss the criteria for diagnosis and possible pathogenesis.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London, UK. sic@globalnet.co.uk
authors.forename: S I
authors.initials: SI
authors.lastname: Chaudhry
authors.forename: L-A
authors.initials: LA
authors.lastname: Murphy
authors.forename: I R
authors.initials: IR
authors.lastname: White
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007822:Laryngeal Neoplasms / Q000150:complications*; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D003879:Dermatologic Agents; D006886:Hydroxychloroquine