Characterization of indomethacin-loaded lipid nanoparticles by differential scanning calorimetry.
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are interesting nanoparticulate delivery systems produced from solid lipids. Both carrier types are submicron size particles but they can be distinguished by their inner structure. In the present paper, indomethacin (IND)-loaded SLN and NLC were prepared and the organization and distribution of the different ingredients originating each type of nanoparticle system were studied by differential scanning calorimetry (DSC) technique. Furthermore, mean particle size and percentage of drug encapsulation were also determined. From the results obtained, NLC lipid organization guaranteed an increased indomethacin encapsulation in comparison with SLN. DSC static and dynamic measurements performed on SLN and NLC showed that oil nanocompartments incorporated into NLC solid matrix drastically influenced drug distribution inside the nanoparticle system. Controlled release from NLC system could be explained considering both drug partition between oil nanocompartments and solid lipid and a successive partition between solid lipid and water.
Castelli
Francesco
F
Department of Chemical Sciences, University of Catania, Viale A. Doria no. 6, 95125 Catania, Italy. fcastelli@dipchi.unict.it
Puglia
Carmelo
C
Sarpietro
Maria Grazia
MG
Rizza
Luisa
L
Bonina
Francesco
F
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D007213:Indomethacin / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures; D010316:Particle Size; D012995:Solubility
D004337:Drug Carriers; D008055:Lipids; D007213:Indomethacin