High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection.
Gentamicin and tobramycin are two aminoglycosides commonly impregnated into polymethylmethacrylate for treatment and prevention of prosthetic joint infection. Susceptibilities of staphylococci to aminoglycosides are not reported routinely in the United States. The gentamicin and tobramycin minimum inhibitory value of 93 staphylococci from patients with PJI were determined. Forty-one and 66% of the isolates were resistant to gentamicin and tobramycin, respectively. Methicillin-resistant Staphylococcus aureus isolates were more likely to be resistant to gentamicin or tobramycin than were their methicillin susceptible counterparts. The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection.
Anguita-Alonso
Paloma
P
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Hanssen
Arlen D
AD
Osmon
Douglas R
DR
Trampuz
Andrej
A
Steckelberg
James M
JM
Patel
Robin
R
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001843:Bone Cements; D024901:Drug Resistance, Multiple, Bacterial; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D016106:Methicillin Resistance; D019904:Polymethyl Methacrylate; D019736:Prostheses and Implants / Q000382:microbiology; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*; D014031:Tobramycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins; D019904:Polymethyl Methacrylate; D014031:Tobramycin