[Lymphocytic infiltration after oral administration of tamsulosin (Alna)].
A 69-year old patient developed dark red plaques located at his trunk, rima ani, both sides of his elbows and on his fingers after oral administration of tamsulosin (Alna). The skin eruptions disappeared and recurred in a reproducible fashion when tamsulosin was briefly discontinued. A skin biopsy taken from a UVA-exposed area on the back showed the histological features of a lymphocytic infiltration. Type-I and type-IV allergic reactions against tamsulosin could not be detected by prick and epicutaneous tests. To our knowledge this is the first report describing a lymphocytic infiltrated caused by tamsulosin. The skin eruptions disappeared and have not recurred since the medication was discontinued.
Diesler
Sandra
S
Klinik und Poliklinik für Dermatologie und Venerologie der Universität Köln, Deutschland.
Hirche
Frank
F
Krieg
Thomas
T
Hunzelmann
Nicolas
N
D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D008218:Lymphocytosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012651:Self Medication; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D000077409:Tamsulosin
D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin