Fatal HHV-6 associated encephalitis in an HIV-1 infected patient treated with cidofovir.
We describe the case of a patient infected with HIV and a concomitant HHV-6 encephalitis. The patient experienced virological failure following cidofovir treatment. RT-PCR was used both for early diagnosis and follow-up.
Astriti
Myrto
M
Department of Infectious Diseases, Pitié-Salpêtrière Hospital, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
Zeller
Valérie
V
Boutolleau
David
D
Gautheret-Dejean
Agnès
A
Allen
George
G
Seilhean
Danielle
D
Agut
Henri
H
Bricaire
François
F
Katlama
Christine
C
Bossi
Philippe
P
D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001706:Biopsy; D001921:Brain / Q000473:pathology / Q000821:virology; D000077404:Cidofovir; D003596:Cytosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018792:Encephalitis, Viral / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D063065:Organophosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D016133:Polymerase Chain Reaction; D019349:Roseolovirus Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D019562:Viral Load
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir