title: Clinicopathological features of and risk factors for multiple primary melanomas.
abstract: BACKGROUND
  The incidence of multiple primary melanomas ranges from 1.3% to 8.0% in large retrospective reviews; however, the impact of certain risk factors is not understood.
  
  
  OBJECTIVE
  To determine the incidence of multiple primary melanomas (MPM) from a prospective, single-institution, multidisciplinary database, and to describe the clinical and pathological characteristics and risk factors specific to these patients.
  
  
  METHODS
  Review of a prospectively maintained database at Memorial Sloan-Kettering Cancer Center in New York, NY.
  
  
  METHODS
  A total of 4484 patients diagnosed with a first primary melanoma between January 1, 1996, and December 31, 2002.
  
  
  METHODS
  Incidence of and risk factors for MPM.
  
  
  RESULTS
  Three hundred eighty-five patients (8.6%) had 2 or more primary melanomas, with an average of 2.3 melanomas per MPM patient. Seventy-eight percent had 2 primary melanomas. For 74% of patients, the initial melanoma was the thickest tumor. Fifty-nine percent presented with their second primary tumor within 1 year. Twenty-one percent of MPM patients had a positive family history of melanoma compared with only 12% of patients with a single primary melanoma (SPM) (P<.001). Thirty-eight percent of MPM patients had dysplastic nevi compared with 18% of SPM patients (P<.001). The estimated cumulative 5-year risk of a second primary tumor for the entire cohort was 11.4%, with almost half of that risk occurring within the first year. For patients with a positive family history or dysplastic nevi, the estimated 5-year risk of MPM was significantly higher at 19.1% and 23.7%, respectively. The most striking increase in incidence for the MPM population was seen for development of a third primary melanoma from the time of second primary melanoma, which was 15.6% at 1 year and 30.9% at 5 years.
  
  
  CONCLUSIONS
  The incidence of MPM is increased in patients with a positive family history and/or dysplastic nevi. These patients should undergo intensive dermatologic screening and should consider genetic testing.
authors.affiliation: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Cristina R
authors.initials: CR
authors.lastname: Ferrone
authors.forename: Leah
authors.initials: L
authors.lastname: Ben Porat
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Panageas
authors.forename: Marianne
authors.initials: M
authors.lastname: Berwick
authors.forename: Allan C
authors.initials: AC
authors.lastname: Halpern
authors.forename: Ami
authors.initials: A
authors.lastname: Patel
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Coit
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000473:pathology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000473:pathology