title: Cell biology. A fungal Achilles' heel.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. heitm001@duke.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitman
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects / Q000235:genetics; D016227:Benzoquinones; D005075:Biological Evolution; D019703:Calcineurin / Q000502:physiology*; D065095:Calcineurin Inhibitors; D002176:Candida albicans / Q000187:drug effects / Q000235:genetics; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D004875:Ergosterol / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D047029:Lactams, Macrocyclic; D009154:Mutation; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D010641:Phenotype; D011809:Quinones / Q000494:pharmacology / Q000627:therapeutic use; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D016559:Tacrolimus / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D016227:Benzoquinones; D065095:Calcineurin Inhibitors; C074510:HSP82 protein, S cerevisiae; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D011809:Quinones; D029701:Saccharomyces cerevisiae Proteins; D016572:Cyclosporine; D019703:Calcineurin; D016559:Tacrolimus; D004875:Ergosterol; C001277:geldanamycin