title: Diastereomeric quinolinone alkaloids from the marine-derived fungus Penicillium janczewskii.
abstract: From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.
authors.affiliation: Leibniz-Institute for Natural Products Research and Infection Biology, Hans-Knöll-Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Ulrich
authors.initials: U
authors.lastname: Lion
authors.forename: Isabel
authors.initials: I
authors.lastname: Sattler
authors.forename: Friedrich A
authors.initials: FA
authors.lastname: Gollmick
authors.forename: Susanne
authors.initials: S
authors.lastname: Grabley
authors.forename: Jingmin
authors.initials: J
authors.lastname: Cai
authors.forename: Marinus
authors.initials: M
authors.lastname: Meiners
authors.forename: Henning
authors.initials: H
authors.lastname: Schünke
authors.forename: Karsten
authors.initials: K
authors.lastname: Schaumann
authors.forename: Ute
authors.initials: U
authors.lastname: Dechert
authors.forename: Michael
authors.initials: M
authors.lastname: Krohn
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D009659:North Sea; D010407:Penicillium / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D015363:Quinolones