title: A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor.
abstract: The 70% aqueous methanolic extract of the Peruvian plant Oryctanthus sp. was found to contain a novel saccharide of a diene alpha,omega-diacid. Compound 1 was identified as an inhibitor of the VEGF receptor. The structure of this compound was established based on NMR studies. Compound 1 inhibited ligand binding to the VEGF receptor with an IC50 of 5.0 microM.
authors.affiliation: Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hegde@spcorp.com
authors.forename: Vinod R
authors.initials: VR
authors.lastname: Hegde
authors.forename: Haiyan
authors.initials: H
authors.lastname: Pu
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Adrian
authors.initials: A
authors.lastname: Jachens
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Gullo
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D040262:Receptors, Vascular Endothelial Growth Factor