title: Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides.
abstract: An analytical HPLC method using CHIREX (S)-LEU/(S)-alpha-NEA column was developed for the determination of the enantiomeric excesses of N-protected (S)-3-hydroxyglutarimides. Using this method, detailed studies on the base-promoted ring-expansion reaction of the amidolactones, derived from l-glutamic acid, were undertaken.
authors.affiliation: Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Fujian, PR China. ypruan@jingxian.xmu.edu.cn
authors.forename: Yuan-Ping
authors.initials: YP
authors.lastname: Ruan
authors.forename: Bang-Guo
authors.initials: BG
authors.lastname: Wei
authors.forename: Xiu-Qing
authors.initials: XQ
authors.lastname: Xu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Yu
authors.forename: Liang-Xian
authors.initials: LX
authors.lastname: Liu
authors.forename: Pei-Qiang
authors.initials: PQ
authors.lastname: Huang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006900:Hydroxylation; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010881:Piperidones; C007864:glutarimide