title: Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.
abstract: A series of novel 4,2-bisheterocycle tandem derivatives consisting of a methyloxazole and thiazole subunit were synthesized. Many compounds were found to inhibit human influenza A virus. Several analogues exhibited moderate biological activity and could serve as leads for further optimizations for antivirus research.
authors.affiliation: Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Wang
authors.forename: De-Yong
authors.initials: DY
authors.lastname: Yao
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.forename: Min-Zhi
authors.initials: MZ
authors.lastname: Fan
authors.forename: Jing-Ya
authors.initials: JY
authors.lastname: Li
authors.forename: Ya-Cheng
authors.initials: YC
authors.lastname: Xing
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Nan
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D029521:Alphainfluenzavirus / Q000187:drug effects*; D010080:Oxazoles / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D010080:Oxazoles; D013844:Thiazoles