title: Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.
abstract: We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523-1682, USA. christine.johnson@colostate.edu
authors.forename: Christine M
authors.initials: CM
authors.lastname: Johnson
authors.forename: Rajesh
authors.initials: R
authors.lastname: Pandey
authors.forename: Sadhna
authors.initials: S
authors.lastname: Sharma
authors.forename: G K
authors.initials: GK
authors.lastname: Khuller
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Basaraba
authors.forename: Ian M
authors.initials: IM
authors.lastname: Orme
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Lenaerts
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D002214:Capsules; D004337:Drug Carriers; D005260:Female; D006168:Guinea Pigs; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D049329:Nanostructures; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D002214:Capsules; D004337:Drug Carriers