title: Prognostic value of serum amyloid A protein in patients with acute myocardial infarction.
abstract: BACKGROUND
  The relationship between plasma levels of serum amyloid A protein (SAA) concentrations and clinical course (including mortality) was investigated in patients with acute myocardial infarction (AMI).
  
  
  RESULTS
  The study enrolled 280 consecutive AMI patients who were admitted within 10 h of onset and were successfully reperfused by primary percutaneous coronary intervention. Plasma SAA concentrations were evaluated at 24 h after onset. The threshold of the upper quintile (325 mug/dl) was used to divide patients into 2 groups: either a high SAA (H group: > or =325 mug/dl; n=56) or low SAA (L group: <325 microg/dl; n=224). (I) Left ventricular (LV) ejection fraction in the chronic phase was significantly less in the H group than in the L group (52+/-14% vs 57+/-13%, p=0.03). (II) There were significantly more major complications in the H group than in the L group (cardiac rupture: p=0.0007, cardiogenic shock: p<0.0001; subacute thrombosis: p=0.0007; cardiac death: p=0.0003). (III) Multivariate analysis identified SAA as an independent predictor of 6-month mortality in AMI patients (risk ratio: 5.8, 95%confidence interval: 1.3-27.7, p=0.03).
  
  
  CONCLUSIONS
  In the setting of AMI, plasma SAA concentrations may be closely related to LV systolic dysfunction and poor patient outcomes, including mortality.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Biomedical Science, Nagasaki University, Japan. snowman-kt@syd.odn.ne.jp
authors.forename: Toshiro
authors.initials: T
authors.lastname: Katayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Chisa
authors.initials: C
authors.lastname: Takagi
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Honda
authors.forename: Shin
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Yano
mesh_terms: D000208:Acute Disease; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D000685:Serum Amyloid A Protein / Q000032:analysis*; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000209:etiology / Q000401:mortality
chemical_list: D000685:Serum Amyloid A Protein