[A dynamic model of total chronic heart failure in rats].
A dynamic model ofbiventricular chronic heart failure (CHF) induced by fractional introduction of silicon oil into the pleural cavity in rats is proposed. Silicon oil led to enlargement of the heart, myocardial hypertrophy of both ventricles, considerable pulmonary and hepatic congestion due to circulatory failure, decreased stroke volume and cardiac output, increased peripheral vascular resistance, changes in the activity of sympathoadrenal system of the heart and blood. The severity of the induced CHF varied with the dose and number of silicon oil administrations.
Fedorov
V N
VN
Ialtsev
A V
AV
Danilova
O V
OV
Sidorov
A V
AV
Kataev
V V
VV
D000818:Animals; D002303:Cardiac Output, Low / Q000139:chemically induced* / Q000503:physiopathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D051381:Rats; D012827:Silicone Oils / Q000008:administration & dosage / Q000633:toxicity*
D012827:Silicone Oils