[Immunohistochemical expression of the p53 and Ki-67 proteins in Barrett's esophagus in Korea].
OBJECTIVE
Barrett's esophagus is a premalignant lesion of the esophagus in which normal squamous epithelium is replaced by intestinalized columnar epithelium. In Korea, adenocarcinoma associated with Barrett's esophagus is rare compared with that of Western country. The purpose of this study was to investigate the immunohistochemical expression of p53 and Ki-67 in Barrett's esophagus which had predictive value for cancer risk in Korea.


METHODS
Ninety five patients (43 male and 52 female, median age 44, range 21-75) who have been suspected to have Barrett's esophagus by endoscopic assessment were enrolled in this study. Alcian blue (pH 2.5) and high ion diamine stain for the evaluation of specialized intestinal metaplasia (SIM) and immunohistochemical stain for p53 and Ki-67 were done.


RESULTS
57.9% (55/95) of biopsies from the columnar lined esophagus showed SIM, but no dysplasia. 56.4% (31/55) of Barrett's esophagus showed sulfomucin positive colonic metaplasia. The p53 expression was observed in 10.9% (6/55) of the patients of Barrett's esophagus and all of them showed colonic metaplasia. Ki-67 labeling index showed no difference significantly.


CONCLUSIONS
In Korea, 10.9% of Barrett's esophagus had p53 mutation and moreover all of them had colonic metaplasia. Consequently, we expect that these patients have high risk of developing dysplasia and adenocarcinoma and need careful follow-up.
Kim
Chang Whan
CW
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Lee
Bo In
BI
Kim
Beung Wook
BW
Kim
Jin Il
JI
Park
Soo Heon
SH
Kim
Jae Kwang
JK
Han
Sok Won
SW
Jung
In Sik
IS
Sun
Hee Sik
HS
Lee
A Won
AW
Lee
Kyo Young
KY
D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics; D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000150:complications / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000209:etiology / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53