title: Fatal pulmonary infection associated with a novel organism, "para-streptomyces abscessus".
abstract: Actinomycetes are increasingly recognized as pathogenic in the immunocompromised host. We isolated an asporogenous, nonmotile, aerobic gram-positive rod from a transplant recipient with a fatal pulmonary infection. The pathology was similar to that associated with Rhodococcus equi, including intra-histiocytic localization. The organism was relatively inert in standard biochemical tests. 16S rRNA gene sequencing indicated a potentially unique organism most closely related to the genus Streptomyces, for which we propose the name "Para-streptomyces abscessus."
authors.affiliation: Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA.
authors.forename: W Garrett
authors.initials: WG
authors.lastname: Nichols
authors.forename: Jennifer
authors.initials: J
authors.lastname: Prentice
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Houze
authors.forename: LaDonna
authors.initials: L
authors.lastname: Carlson
authors.forename: Brad T
authors.initials: BT
authors.lastname: Cookson
mesh_terms: D000193:Actinomycetales Infections / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D004275:DNA, Ribosomal / Q000032:analysis; D017809:Fatal Outcome; D020459:Genes, rRNA; D006801:Humans; D008171:Lung Diseases / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013306:Streptomycetaceae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S