Effect of Aerodiol administration on cerebral blood flow volume in postmenopausal women.
OBJECTIVE
The aim of the study was to evaluate the acute effect of the intranasal 17beta-estradiol (Aerodiol, Servier, Chambray-les-Tours, France) administration on cerebral blood flow (CBF) volume.


METHODS
Eighteen healthy women who had been natural postmenopausal for at least 1 year were enrolled in the study. We conducted an experimental, randomized, placebo-controlled, crossover, double-blinded study of the acute effect of 17beta-estradiol on the internal carotid artery (ICA), vertebral artery (VA) and, CBF volume using color duplex sonography.


RESULTS
There were significant increases in the ICA, VA flow volumes and CBF volume after 17beta-estradiol administration compared to placebo measurements. However, there was no statistically significant difference in flow velocities or pulsatility indices.


CONCLUSIONS
Nasal 17beta-estradiol administration in postmenopausal women causes significant increases in CBF volume due to its vasodilatatory effect on ICA and VA.
Acar
Murat
M
Afyon Kocatepe University Faculty of Medicine, Department of Radiology, Kirmizi Hastane, Turkey. drmacar@hotmail.com
Cevrioglu
Arif Serhan
AS
Haktanir
Alpay
A
Demirel
Reha
R
Albayrak
Ramazan
R
Degirmenci
Bumin
B
Yucel
Aylin
A
Akyol
Ahmet Melih
AM
D000281:Administration, Intranasal; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D018615:Ultrasonography, Doppler, Color; D017585:Ultrasonography, Doppler, Transcranial; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000187:drug effects
D004958:Estradiol