Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. Küppers has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.
Weller
Sandra
S
INSERM U373 , Faculté de Médecine René Descartes, Paris, France.
Reynaud
Claude-Agnès
CA
Weill
Jean-Claude
JC
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D003564:Cytidine Deaminase; D043525:Cytosine Deaminase / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D009154:Mutation; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D007136:Immunoglobulins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D043525:Cytosine Deaminase; D003564:Cytidine Deaminase