title: Non-small cell lung cancer coexisting with pulmonary aspergilloma.
abstract: A 77-year-old male with a long-standing history of smoking and working in mines was referred to our department for the evaluation of an enlarging subpleural mass in the right upper lobe. Both transbronchial and computed tomography-guided biopsies of the mass were non-diagnostic. A partial resection of the right S2 mass under video-assisted thoracic surgery (VATS) confirmed the diagnosis of primary non-small cell lung cancer. VATS right upper lobectomy (ND2a) was then performed for complete resection. Histological examination revealed that the mass composed of adenocarcinoma and the dilated bronchioles contained Aspergillus, the fungal component. Here we report a rare case of non-small cell lung cancer coexisting with pulmonary aspergillosis. The morphologic coexistence pattern of the two pathologies was believed to be the colonization of saprophytic Aspergillus in the bullous air spaces, obstructed by or contained within the tumor, according to the progression of the lung cancer.
authors.affiliation: Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Itano
authors.forename: Akio
authors.initials: A
authors.lastname: Andou
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001228:Aspergillosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004391:Dust; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male; D008906:Mining; D016273:Occupational Exposure; D012307:Risk Factors; D012907:Smoking; D020775:Thoracic Surgery, Video-Assisted
chemical_list: D004391:Dust