title: Multicomponent synthesis of spiroisoxazolines.
abstract: A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.
authors.affiliation: Centre for Synthesis and Chemical Biolog, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland. madamo@rcsi.ie
authors.forename: Mauro F A
authors.initials: MF
authors.lastname: Adamo
authors.forename: Donato
authors.initials: D
authors.lastname: Donati
authors.forename: Eleanor F
authors.initials: EF
authors.lastname: Duffy
authors.forename: Piero
authors.initials: P
authors.lastname: Sarti-Fantoni
mesh_terms: D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007555:Isoxazoles; D013141:Spiro Compounds