Myelofibrosis-associated massive splenomegaly: a cause of increased intra-abdominal pressure, pulmonary hypertension, and positional dyspnea.
We describe a patient with myelofibrosis, giant splenomegaly, and pulmonary hypertension related to increased intra-abdominal pressure. Focusing on alterations in hemodynamic studies, we conclude that in patients with myelofibrosis, dyspnea, and hypoxemia, the measurement of intra-abdominal pressure should be included in the initial evaluation. It is an inexpensive, non-invasive diagnostic tool that can provide crucial information about the cause of dyspnea and disclose the pathogenetic link between massive splenomegaly and pulmonary compromise in myelofibrosis.
Ziakas
Panayiotis D
PD
University of Athens Medical School, Department of Pathophysiology, Athens, Greece.
Voulgarelis
Michael
M
Felekouras
Evagelos
E
Anagnostou
Dimitra
D
Tzelepis
George E
GE
D000005:Abdomen; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D000860:Hypoxia; D008875:Middle Aged; D011312:Pressure; D055728:Primary Myelofibrosis / Q000150:complications* / Q000188:drug therapy; D013163:Splenomegaly / Q000150:complications*