Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.
In a small controlled study, clevudine, a potent inhibitor of hepadnaviruses, including hepatitis B virus and woodchuck hepatitis virus, suppressed hepatitis delta virus (HDV) viremia in chronically infected woodchucks. Suppression was correlated with the marked reduction of woodchuck hepatitis virus surface antigen in individual animals, consistent with the concept that repression of surface antigen expression may be a useful antiviral strategy for HDV.
Casey
John
J
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA. caseyj@georgetown.edu
Cote
Paul J
PJ
Toshkov
Illia A
IA
Chu
Chung K
CK
Gerin
John L
JL
Hornbuckle
William E
WE
Tennant
Bud C
BC
Korba
Brent E
BE
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D018963:Hepatitis Antigens / Q000032:analysis; D017919:Hepatitis B Virus, Woodchuck / Q000187:drug effects*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D003698:Hepatitis Delta Virus / Q000187:drug effects*; D007700:Kinetics; D008392:Marmota; D010865:Pilot Projects; D013997:Time Factors; D014481:United States; D014766:Viremia / Q000188:drug therapy / Q000517:prevention & control / Q000821:virology
D000998:Antiviral Agents; D018963:Hepatitis Antigens; D001086:Arabinofuranosyluracil; C034935:clevudine