SNPselector: a web tool for selecting SNPs for genetic association studies.
CONCLUSIONS
Single nucleotide polymorphisms (SNPs) are commonly used for association studies to find genes responsible for complex genetic diseases. With the recent advance of SNP technology, researchers are able to assay thousands of SNPs in a single experiment. But the process of manually choosing thousands of genotyping SNPs for tens or hundreds of genes is time consuming. We have developed a web-based program, SNPselector, to automate the process. SNPselector takes a list of gene names or a list of genomic regions as input and searches the Ensembl genes or genomic regions for available SNPs. It prioritizes these SNPs on their tagging for linkage disequilibrium, SNP allele frequencies and source, function, regulatory potential and repeat status. SNPselector outputs result in compressed Excel spreadsheet files for review by the user.


BACKGROUND
SNPselector is freely available at http://primer.duhs.duke.edu/
Xu
Hong
H
The Duke Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA.
Gregory
Simon G
SG
Hauser
Elizabeth R
ER
Stenger
Judith E
JE
Pericak-Vance
Margaret A
MA
Vance
Jeffery M
JM
Züchner
Stephan
S
Hauser
Michael A
MA
D000465:Algorithms; D000483:Alleles; D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics; D002874:Chromosome Mapping; D030541:Databases, Genetic; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D020407:Internet; D008957:Models, Genetic; D010455:Peptides / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012984:Software; D014584:User-Computer Interface
D010455:Peptides