Video-rate near-infrared optical tomography using spectrally encoded parallel light delivery.
A novel parallel source implementation approach to near-infrared tomography is demonstrated through spectral encoding of the light delivery. This new technique allows many sources to be input into the tissue at the same time, and a high-resolution spectrometer is used to spatially spread out the signals from each spectrally encoded source. The parallel sampling of all sources at all detection locations renders rapid imaging. Acquisition of complete tomographic data sets at a video rate of 35 frames/s is achieved for imaging of a 6.35 mm diameter inclusion with an absorption coefficient of 0.01 mm(-1) and a reduced scattering coefficient of 1.5 mm(-1) that is moving along a circular path inside a 1% Intralipid solution.
Piao
Daqing
D
Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA. daqing.piao@dartmouth.edu
Jiang
Shudong
S
Srinivasan
Subhadra
S
Dehghani
Hamid
H
Pogue
Brian W
BW
D003199:Computer Systems; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008029:Lighting / Q000295:instrumentation* / Q000379:methods; D018715:Microscopy, Video / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D018511:Systems Integration; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods; D014159:Transducers