Cross-sensitivity between paclitaxel and docetaxel in a women's cancers program.
OBJECTIVE
With the use of steroid premedication, the incidence of severe hypersensitivity reactions (S-HSR) to paclitaxel is estimated to be 2%. For those who develop a S-HSR to paclitaxel, docetaxel has been employed as an alternative agent though the presence of cross-sensitivity has not been established. We sought to define the incidence of S-HSR to docetaxel following a paclitaxel S-HSR in an academic women's cancer program.


METHODS
Patients treated with either paclitaxel (P) or docetaxel (D) between 11/1999 and 8/2004 were identified through our pharmacy database. Records were reviewed and data collected on those patients who had a S-HSR, defined as symptoms for which drug was discontinued, to P, D, or both.


RESULTS
718 patients received P and 93 received D. 59 received D following treatment with P. The presence of S-HSR for P was 2.2% (16/718 patients) and for D was 9.7% (9/93 patients). 10 patients with S-HSR to P crossed over to D and all nine patients reacting to D had a prior reaction to T for a cross-sensitivity rate of 90% (9/10 patients).


CONCLUSIONS
Cross-sensitivity of D after P was 90% at our institution. Given the different vehicles used in P and D, it is likely attributed to the taxane moiety. Caution is required with re-challenge of patients with docetaxel if they have previously reacted to paclitaxel.
Dizon
Don S
DS
Program in Women's Oncology and the Department of Pharmacy, Women and Infants' Hospital, 101 Dudley Street, Providence, RI 02905, USA. ddizon@wihri.org
Schwartz
Joanna
J
Rojan
Adam
A
Miller
Jane
J
Pires
Leslie
L
Disilvestro
Paul
P
Gordinier
Mary E
ME
Moore
Richard
R
Granai
Cornelius O
CO
Legare
Robert D
RD
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D000077143:Docetaxel; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D006801:Humans; D017239:Paclitaxel / Q000009:adverse effects*; D012189:Retrospective Studies; D043823:Taxoids / Q000009:adverse effects*
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel