Influence of antipyretic drugs on the labeling of blood elements with technetium-99m.
Acetaminophen (AAP), acetylsalicylic acid (ASA) and dipyrone (DIP) are antipyretic and analgesics drugs that have wide use in health sciences. Some drugs can modify the labeling of blood elements with technetium-99m (99mTc). This work has evaluated the effect of AAP, ASA and DIP on the labeling of the blood elements with 99mTc. Blood was incubated with different concentrations of the drugs before the 99mTc-labeled process. Plasma (P), blood cells (BC), insoluble (IF-P, IF-BC) and soluble (SF-P, SF-BC) fractions were separated and percentage of radioactivity (%ATI) in each fraction was determined. Data have shown that the antipyretic drugs used in this study did not significantly modify the fixation of 99mTc on the blood elements when the experiments were carried out with the doses usually used in human beings. Although the experiments were carried out with rats, it is possible to suggest that AAP, ASA or DIP should not interfere with the procedures in nuclear medicine involving the labeling of blood elements with 99mTc.
Fonseca
A S
AS
Departamento de Farmacologia e Psicobiologia, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro 87, fundos, 5 andar, 20551-030, Rio de Janeiro, Brasil. adenilso@uerj.br
Frydman
J N G
JN
Santos
R
R
Bernardo-Filho
M
M
D000082:Acetaminophen / Q000378:metabolism; D018712:Analgesics, Non-Narcotic / Q000378:metabolism*; D000818:Animals; D001241:Aspirin / Q000378:metabolism; D001773:Blood Cells / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D004177:Dipyrone / Q000378:metabolism; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D010949:Plasma / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013667:Technetium / Q000378:metabolism*
D018712:Analgesics, Non-Narcotic; D001798:Blood Proteins; D000082:Acetaminophen; D004177:Dipyrone; D013667:Technetium; D001241:Aspirin