title: Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration.
abstract: The inhibitory effects of a black tea extract on fatty acid synthase were measured through inhibition kinetics. The Keemun black tea extract showed more potent inhibitory activity on fatty acid synthase than green tea extract. Additionally, the inhibitory ability of the black tea extract depended on the extracting solvent and the conditions used. Only 10-23% of the inhibitory activity from the black tea was extracted by the general method of boiling with water. The results suggested that the main fatty acid synthase inhibitors in black tea might be theaflavins. Which were more potent than epigallocatechin gallate or C75. The reaction site on the fatty acid synthase and the inhibition kinetics for the extract were different from those of epigallocatechin gallate or C75. In addition, Keemun black tea extract significantly reduced food intake, body weight and blood triglyceride of diet-induced obesity SD rats via oral administration.
authors.affiliation: Department of Biology, Graduate School of Chinese Academy of Sciences, Beijing, People's Republic China.
authors.forename: Ya-Tao
authors.initials: YT
authors.lastname: Du
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wu
authors.forename: Wei-Xi
authors.initials: WX
authors.lastname: Tian
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D013662:Tea; D064429:Fatty Acid Synthases