Synthesis and stability of exocyclic triazine nucleosides.
Synthesis and stability studies of exocyclic amino triazine nucleosides were performed. Stability of the nucleosides was found to be dependent on triazine ring electron density, solvent, and pH. The nucleosides were found to be more stable when the triazine ring was electron deficient, in high pH aqueous solutions and in aprotic solvents.
Hysell
Michelle
M
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, USA.
Siegel
Jay S
JS
Tor
Yitzhak
Y
D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
D009705:Nucleosides; D014227:Triazines