beta-cyclodextrin-immobilized (4S)-phenoxy-(S)-proline as a catalyst for direct asymmetric aldol reactions.
beta-Cyclodextrin-immobilized (4S)-phenoxy-(S)-proline was prepared conveniently by simply heating the amino acid and beta-cyclodextrin in ethanol-water (1/1, v/v) and removal of the solvent. This proved to be an efficient catalyst for direct asymmetric aldol reactions, and the catalyst could be recycled four times without loss of enantioselectivity.
Shen
Zongxuan
Z
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, China.
Ma
Jimei
J
Liu
Yanhua
Y
Jiao
Chongjun
C
Li
Ming
M
Zhang
Yawen
Y
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013057:Spectrum Analysis; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry*
C507396:4-phenoxyproline; D000447:Aldehydes; D012997:Solvents; D047392:beta-Cyclodextrins; C116609:3-hydroxybutanal; D011392:Proline