title: Caffeine and psychiatric medication interactions: a review.
abstract: Caffeine can cause or worsen psychiatric symptoms but also has the potential to interact with many psychiatric medications. This article provides a literature review regarding interactions between caffeine and psychiatric medications. Caffeine is metabolized by the CYP1A2 enzyme and also acts as a competitive inhibitor of this enzyme. Thus, caffeine can interact with a wide range of psychiatric medications, including antidepressant agents, antipsychotic agents, antimanic agents, antianxiety agents, and sedative agents. These interactions may lead to caffeine-related or medication-related side effects that may complicate psychiatric treatment. By recognizing this potential, along with educating the patient, and utilizing a tapering approach, prevention of caffeine interactions is achievable.
authors.affiliation: University of Oklahoma, USA.
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Broderick
authors.forename: Ashley B
authors.initials: AB
authors.lastname: Benjamin
authors.forename: Leland W
authors.initials: LW
authors.lastname: Dennis
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000494:pharmacology; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology; D018692:Antimanic Agents / Q000009:adverse effects / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology; D002110:Caffeine / Q000009:adverse effects* / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000494:pharmacology; D008487:Medical History Taking; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs; D002110:Caffeine