Approach to magnetic neutron capture therapy.
OBJECTIVE
The method of magnetic neutron capture therapy can be described as a combination of two methods: magnetic localization of drugs using magnetically targeted carriers and neutron capture therapy itself.


METHODS
In this work, we produced and tested two types of particles for such therapy. Composite ultradispersed ferro-carbon (Fe-C) and iron-boron (Fe-B) particles were formed from vapors of respective materials.


RESULTS
Two-component ultradispersed particles, containing Fe and C, were tested as magnetic adsorbent of L-boronophenylalanine and borax and were shown that borax sorption could be effective for creation of high concentration of boron atoms in the area of tumor. Kinetics of boron release into the physiologic solution demonstrate that ultradispersed Fe-B (10%) could be applied for an effective magnetic neutron capture therapy.


CONCLUSIONS
Both types of the particles have high magnetization and magnetic homogeneity, allow to form stable magnetic suspensions, and have low toxicity.
Kuznetsov
Anatoly A
AA
Institute of Biochemical Physics of RAS, Moscow, Russia. spod@sky.chph.ras.ru
Podoynitsyn
Sergey N
SN
Filippov
Victor I
VI
Komissarova
Lubov Kh
LKh
Kuznetsov
Oleg A
OA
D001895:Boron / Q000737:chemistry / Q000627:therapeutic use; D001896:Boron Compounds / Q000737:chemistry / Q000627:therapeutic use; D002244:Carbon / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000627:therapeutic use*; D007501:Iron / Q000737:chemistry; D008280:Magnetics / Q000627:therapeutic use*; D036103:Nanotechnology; D017247:Neutron Capture Therapy / Q000379:methods*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000627:therapeutic use
D001896:Boron Compounds; D004337:Drug Carriers; D010649:Phenylalanine; D002244:Carbon; D007501:Iron; D001895:Boron; C033685:4-boronophenylalanine