title: Histologic and clinical significance of atypical glandular cells on pap smears.
abstract: OBJECTIVE
  To determine the association between atypical glandular cells (AGC) on Pap smear and clinically significant histology, in a large health region.
  
  
  METHODS
  A cytologic database of over one million Pap smears was reviewed for a result of AGUS/AGC. Cytologic and histologic follow up was obtained to establish the presence of significant histology.
  
  
  RESULTS
  456 patients available for follow up had AGUS/AGC cytology results (0.043% of all Pap smear results). 197(45.2%) patients had a clinically significant diagnosis including 40 with adenocarcinoma in situ (AIS) of the cervix and 48 with endometrial cancer.
  
  
  CONCLUSIONS
  AGC on a Pap smear is frequently associated with a clinically significant diagnosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alberta, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Daniel
authors.forename: D
authors.initials: D
authors.lastname: Barreth
authors.forename: A
authors.initials: A
authors.lastname: Schepansky
authors.forename: G
authors.initials: G
authors.lastname: Johnson
authors.forename: V
authors.initials: V
authors.lastname: Capstick
authors.forename: W
authors.initials: W
authors.lastname: Faught
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D012189:Retrospective Studies; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology*