Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.
We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.
Holzmuller
P
P
UR 008 Pathogénie des Trypanosomatidés, IRD (Institut de Recherche pour le Développement), Montpellier, France.
Sereno
D
D
Lemesre
J-L
JL
D000818:Animals; D000966:Antimony Potassium Tartrate / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D004351:Drug Resistance; D020128:Inhibitory Concentration 50; D007371:Interferon-gamma / Q000494:pharmacology; D018314:Leishmania infantum / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development*; D008018:Life Cycle Stages; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000378:metabolism / Q000469:parasitology; D009569:Nitric Oxide / Q000633:toxicity*
D000981:Antiprotozoal Agents; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D007371:Interferon-gamma; D000966:Antimony Potassium Tartrate