[Splenic lymphocyte readiness to proliferation in the offspring of rats with maternal chronic liver pathology].
The aim of the study was to determine splenic lymphocyte readiness to proliferation, as one of the indexes of cell homeostasis, in the offspring of rats with experimentally induced chronic liver disease (toxic lesions, induced by subcutaneous CCl4, and autoimmune lesions, induced by a long-term sensitization by homologous liver antigen). Lymphocyte readiness to proliferation was estimated according to J. Crocker and P. Nar method (1987) based on demonstration of active Nucleolar Organizing Regions (AgNORs) and counting of relative content of NOR-positive cells. It was found that at most time intervals studied, splenic lymphocyte readiness to proliferation in experimental rat pups exceeded that one in control (in intact animals), as indicated by an increase of relative number of NOR-positive cells.
Briukhin
G V
GV
Pashnina
E N
EN
D000818:Animals; D049109:Cell Proliferation; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008099:Liver / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000254:growth & development / Q000473:pathology*