[Factors affecting the prognosis of diffuse large B-cell lymphoma in Chinese].
OBJECTIVE
To study the correlation between clinical prognosis and clinicopathologic features, origin and cell proliferous index of diffuse large B-cell lymphoma (DLBCL) in China.


METHODS
The data of 60 cases of DLBCL were collected with the study of international prognostic index (IPI) and the follow-up results. Immunohistochemistry stain was used to check the expression of CD(45)RO, CD(3), CD(20), CD(79)a, CD(45)RA, Ki-67, p53 and bcl-6.


RESULTS
The ratio of male to female is 1.73 and the average age is 53.1. In 53.3% cases lymph node were involved (32/60), gastric intestinal tract and tonsil were the most common extranodal sites of involvement. 23 patients 38.3% died during follow-up, the longest survival period lasting 108 months.16 died in the first year after establishment of diagnosis (16/23, 69.6%). IPI is an independent prognostic index; the lower the index, the better the prognosis (P = 0.0102). Positive incidence of CD(20), CD(79)a and CD(45)RA was 91.5%, 73.7% and 58.3%. Ki-67, p53, bcl-6 were expressed in some cases (48/53, 90.6%; 26/46, 56.5%; 21/41, 51.2%). The expression of bcl-6 protein was somewhat related with prognosis (P = 0.0049), but the expression of p53 was not (P = 0.5948).


CONCLUSIONS
The clinicopathologic features of DLBCL are similar in the East and the West. It is highly aggressive tumor. Most of the cases died in the first year after establishment of diagnosis. IPI can be used to predict the clinical outcome. The expression of bcl-6 protein was somewhat related with clinical prognosis, but that of p53 was not.
Weng
Yang
Y
Department of Pathology, Peking University, Health Science Center, Beijing 100083, China.
Gao
Zi-fen
ZF
Liu
Kan
K
Zhang
Wei-jing
WJ
Ke
Xiao-yan
XY
Li
Min
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D002648:Child; D002681:China; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D051560:Proto-Oncogene Proteins c-bcl-6; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D019394:Ki-67 Antigen; D051560:Proto-Oncogene Proteins c-bcl-6; D016159:Tumor Suppressor Protein p53