Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407".
We performed a 28-day repeated-dose toxicity study of di(2-ethylhexyl)adipate (DEHA) based on the draft protocol of the "Enhanced OECD Test Guideline 407" to investigate whether it has endocrine-mediated properties according to this assay. DEHA was orally administered to SD rats at doses of 0, 40, 200 and 1,000 mg/kg/day for at least 28 days, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group.
Miyata
Katsumi
K
Chemicals Evaluation and Research Institute, 3-822, Ishii, 877-0061 Hita, Oita, Japan.
Shiraishi
Keiji
K
Houshuyama
Satsuki
S
Imatanaka
Nobuya
N
Umano
Takaaki
T
Minobe
Yasushi
Y
Yamasaki
Kanji
K
D000272:Adipates / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D006728:Hormones / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010968:Plasticizers / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count
D000272:Adipates; D005503:Food Additives; D006728:Hormones; D010968:Plasticizers; C013966:dioctyl adipate