An unusual case of posttransplant peritoneal primary effusion lymphoma with T-cell phenotype in a HIV-negative female, not associated with HHV-8.
Primary effusion lymphoma (PEL) is a recently individualized form of non-Hodgkin's lymphoma (WHO classification) that mainly develops in HIV infected males, more frequently in homosexuals and advanced stages of the disease (total CD4+ lymphocyte count below 100-200/microL). Occasionally, it appears in other immunodepressive states (such as solid organs transplant period) and even, although very rarely, in immunocompetent patients. From a pathogenetic point of view, PEL has been related to Kaposi's sarcoma associated herpes virus (also named human herpesvirus 8, HHV-8), an etiological factor of Kaposi's sarcoma. The relative infrequency of this disease, the absence of wide casuistics allowing a better characterization, and its unfavorable outcome support the need of a deeper knowledge. We present here the clinical-biological findings of a patient, HIV seronegative, who was diagnosed with peritoneal PEL of T-cell origin, and not HHV-8-associated, five years after renal transplantation.
Venizelos
Ioannis
I
Department of Pathology, Ippokratio General Hospital of Salonica, Salonica, Greece.
Tamiolakis
Demetrio
D
Lambropoulou
Maria
M
Nikolaidou
Sylva
S
Bolioti
Sophia
S
Papadopoulos
Hlias
H
Papadopoulos
Nikolas
N
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005260:Female; D018023:HIV Seronegativity; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D018451:Homosexuality, Male; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000032:analysis; D016030:Kidney Transplantation / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*; D008297:Male; D011183:Postoperative Complications / Q000473:pathology
D015703:Antigens, CD; D017730:Ki-1 Antigen