title: Using elderly donors in liver transplantation.
abstract: OBJECTIVE
  Elderly donors are half of the grafts available in our center for liver transplantation. We retrospectively investigated their characteristics, outcomes, and variables related to graft failure.
  
  
  METHODS
  From 1996 to 2003, 540 (46.4%) of 1163 donors were older than 60 years of age and 236 grafts (43.4%) were transplanted, whereas the others were refused. The clinical investigated variables were examined among this cohort.
  
  
  RESULTS
  The median age of donors increased from 37 to 62 years. Donors older than 60 years of age were more often refused than younger ones (66% vs 44%); HCV-positive (9.9% vs 5.4%); HbcAb-positive (18.6% vs 12.6%), and steatotic (35.7% vs 13.9%; P < .01). Among donors older than 60 years, the main parameter to refuse the graft was the grade of steatosis. The variables related to the graft loss from donors older than 60 years were as follows: model for end stage liver disease (MELD) recipient >15 (65% vs 39%), cold ischemia time >10 hours (25% vs 13%), high blood losses (3987 +/- 4764 vs 2664 +/- 2043 mL), and year of liver transplantation after 2000 (26% vs 46%; P < .01). The 1-, 3-, and 5-year graft survival rates were significantly lower among donors older than 60 years than other donors: 75%, 65%, and 62% versus 85%, 83%, and 78%, respectively (P < .001).
  
  
  CONCLUSIONS
  Donors older than 60 years of age provided liver transplants to half of our recipients. The graft survival rate of these organs was lower than that of younger donors and to improve it the other risk variables for poor outcome should be reduced, including MELD score of the recipient and prolonged cold ischemia time.
authors.affiliation: Liver and Multi-organ Transplant Unit, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. glgrazi@unibo.it
authors.forename: G L
authors.initials: GL
authors.lastname: Grazi
authors.forename: M
authors.initials: M
authors.lastname: Ravaioli
authors.forename: M
authors.initials: M
authors.lastname: Zanello
authors.forename: G
authors.initials: G
authors.lastname: Ercolani
authors.forename: M
authors.initials: M
authors.lastname: Cescon
authors.forename: G
authors.initials: G
authors.lastname: Varotti
authors.forename: M
authors.initials: M
authors.lastname: Del Gaudio
authors.forename: G
authors.initials: G
authors.lastname: Vetrone
authors.forename: A
authors.initials: A
authors.lastname: Lauro
authors.forename: G
authors.initials: G
authors.lastname: Ramacciato
authors.forename: A D
authors.initials: AD
authors.lastname: Pinna
mesh_terms: D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000502:physiology*; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D017211:Treatment Failure; D016896:Treatment Outcome