Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.
A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%).
Holm
Caroline
C
Division of Pathology, Department of Laboratory Medicine, Lund University, University Hospital, 205 02 Malmö, Sweden.
Ora
Ingrid
I
Brunhoff
Cecilia
C
Anagnostaki
Lola
L
Landberg
Göran
G
Persson
Jenny Liao
JL
D000293:Adolescent; D000367:Age Factors; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D019925:Cyclin A / Q000096:biosynthesis*; D056750:Cyclin A1; D018572:Disease-Free Survival; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor; C503745:CCNA1 protein, human; D019925:Cyclin A; D056750:Cyclin A1; D009363:Neoplasm Proteins