Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.
Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
Zaragoza
Oscar
O
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Mihu
Coralia
C
Casadevall
Arturo
A
Nosanchuk
Joshua D
JD
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D048429:Cell Size / Q000187:drug effects*; D003453:Cryptococcosis / Q000188:drug therapy*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000235:genetics; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL
D000935:Antifungal Agents; D000666:Amphotericin B