Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates.
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.
Zovko
Marijana
M
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. mzovko@pharma.hr
Barbarić
Monika
M
Zorc
Branka
B
Hafner
Anita
A
Filipović-Grcić
Jelena
J
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D005279:Fenoprofen / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015248:Gemfibrozil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D008298:Maleates / Q000737:chemistry; D011355:Prodrugs; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013343:Styrenes / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000960:Hypolipidemic Agents; D008298:Maleates; D011355:Prodrugs; D013343:Styrenes; C030272:maleic acid; D015248:Gemfibrozil; D005279:Fenoprofen