title: Papillomaviruses: different genes have different histories.
abstract: Papillomaviruses (PVs) infect stratified squamous epithelia in vertebrates. Some PVs are associated with different types of cancer and with certain benign lesions. It has been assumed that PVs coevolved with their hosts. However, recently it has been shown that different regions of the genome have different evolutionary histories. The PV genome has a modular nature and appeared after the addition of pre-existent blocks. This order of appearance in the PV genome is evident today in the different evolutionary rates of the different genes, with new genes--E5, E6 and E7--diverging faster than old genes--E1, E2, L2 and L1. Here, we propose an evolutionary framework aiming to integrate genome evolution, PV biology and epidemiology of PV infections.
authors.affiliation: Evolutionary Genomics Group, Biochemistry and Biotechnology Department, Rovira i Virgili University (URV), c/ Marcel-li Domingo, s/n. Campus Sescelades, 43007 Tarragona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: García-Vallvé
authors.forename: Angel
authors.initials: A
authors.lastname: Alonso
authors.forename: Ignacio G
authors.initials: IG
authors.lastname: Bravo
mesh_terms: D019143:Evolution, Molecular; D005814:Genes, Viral; D016679:Genome, Viral; D027383:Papillomaviridae / Q000235:genetics*; D010802:Phylogeny