title: Prolonged recovery and respiratory depression after fentanyl infusion in a sheep undergoing mitral valve reconstruction.
abstract: A sheep was anaesthetized for implantation of a novel device (MitroFast) to replace the posterior leaflet of the mitral valve. Anaesthetic management included a balanced anaesthetic protocol and consisted of propofol or isoflurane combined with fentanyl infusion (0.15-0.4 microg/kg/min). Deliberate hypothermia during cardiopulmonary bypass was set at 34.5-35.5 degrees C. Surgery proceeded uneventfully. Total time of aortic cross-clamping was 35 min and total time on extracorporeal circulation was 60 min. Visual inspection, intracardiac pressure testing and transesophageal echocardiography indicated proper functioning of the device. The anaesthetic period was uneventful, but recovery was prolonged with central nervous and respiratory depression and marked hypoxaemia. Administration of naloxone (1.5 microg/kg, repeated twice at 15-20 min intervals) reversed the central nervous and attenuated the respiratory depressions. An initially low rate of urine production normalized after rewarming and a single intravenous administration of furosemide.
authors.affiliation: Section of Anaesthesiology, Department of Clinical Veterinary Medicine, University of Berne, Switzerland. peter.kronen@knp.unibe.ch
authors.forename: P W
authors.initials: PW
authors.lastname: Kronen
authors.forename: O L
authors.initials: OL
authors.lastname: Levionnois
authors.forename: F S
authors.initials: FS
authors.lastname: Eckstein
authors.forename: Y P S
authors.initials: YP
authors.lastname: Moens
mesh_terms: D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D000818:Animals; D005260:Female; D005283:Fentanyl / Q000009:adverse effects*; D008944:Mitral Valve Insufficiency / Q000601:surgery* / Q000662:veterinary*; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000188:drug therapy; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000601:surgery
chemical_list: D018686:Anesthetics, Intravenous; D009292:Narcotic Antagonists; D009270:Naloxone; D005283:Fentanyl