Coexistence of psoriasis and linear IgA disease in a patient with recent herpes zoster infection.
We report the case of a 29-year-old man with chronic plaque psoriasis who developed linear IgA disease following herpes zoster infection. There has only been one previous report describing the coexistence of psoriasis and linear IgA disease, which was confirmed by immunopathological studies. In our patient, immunoblotting studies identified IgA antibodies binding to BP180 and BP230 antigens, and IgG autoantibodies binding weakly to the BP180 antigen. This is an interesting case that we believe is an example of epitope spreading in the development of autoimmune subepidermal bullous diseases.
Cooke
N
N
Department of Dermatology, Royal Victoria Hospital, UK. nicolacooke36@hotmail.com
Jenkinson
H
H
Wojnarowska
F
F
McKenna
K
K
Alderdice
J
J
D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D006562:Herpes Zoster / Q000150:complications* / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D024041:Non-Fibrillar Collagens; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000276:immunology / Q000473:pathology; D011565:Psoriasis / Q000150:complications*; D012872:Skin Diseases, Vesiculobullous; D000097805:Collagen Type XVII
D001323:Autoantibodies; D001324:Autoantigens; D007070:Immunoglobulin A; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII