title: Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction.
abstract: We assess the availability of plasma biomarkers to monitor the brain damage and the therapeutic efficacy of edaravone. The study consisted of 51 patients with ischemic cerebral infarcts. They were divided into 2 groups: GI (n = 24) had cortical lesions, and GII (n = 27) had lesions in the basal ganglia or brain stem. Edaravone was administered to 27 randomly selected patients (GIa, n = 13; GIIa, n = 14) and its efficacy was studied by comparing their plasma OxLDL, S-100B, and MnSOD levels to those in patients without edaravone (GIb, n = 11, GIIb, n = 13). Three days after the start of edaravone, plasma OxLDL was significantly lower in GIa than GIb patients (0.177 +/- 0.024 ng/microg apoB vs 0.219 +/- 0.026, P < 0.05). In GIIa patients, pre- and posttreatment plasma OxLDL was not significantly different (0.156 +/- 0.013 vs 0.152 +/- 0.020). In GIa patients, S-100B and MnSOD were significantly lower than in GIb patients (P < 0.05). The neurological condition at the time of discharge had recovered in GIa but not GIb patients. Ours is the first evidence to confirm the efficacy of edaravone by plasma biomarkers. In patients with cortical infarcts, edaravone reduced oxidative damage, thereby limiting the degree of brain damage.
authors.affiliation: Department of Neurosurgery, Graduate School of Health Biosciences, The University of Tokushima, Tokushima, 3-18-15, Tokushima, Japan. muno@clin.med.tokushima-u.ac.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Uno
authors.forename: Keiko T
authors.initials: KT
authors.lastname: Kitazato
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Suzue
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Masahumi
authors.initials: M
authors.lastname: Harada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Itabe
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001253:Astrocytes / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D002544:Cerebral Infarction / Q000188:drug therapy*; D000077553:Edaravone; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009414:Nerve Growth Factors / Q000097:blood*; D018384:Oxidative Stress; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C099252:oxidized low density lipoprotein; D013482:Superoxide Dismutase; D000077553:Edaravone; D000983:Antipyrine