[Porcine submucosa graft for the treatment of duodenal injuries in dogs].
OBJECTIVE
To evaluate the biocompatibility and effectiveness of porcine SIS (small intestinal submucosa), when used as a patch to repair a defect on the anterior duodenal wall.


METHODS
The experimental study was performed in 8 dogs. A segment of the anterior duodenal wall was removed and the defect was repaired with a patch of porcine intestinal submucosa. On the 120th post operative day the animals were sacrificed and the segment of duodenum containing the patch was removed to a macroscopic and microscopic evaluation.


RESULTS
There was no infection, suture dehiscence or fistula. The microscopic evaluation showed complete re-epithelization in 75% of the cases, with moderate fibroblastic proliferation in 87.5% of the cases.


CONCLUSIONS
The porcine SIS used as a patch acts as a tissue substitute for repairing induced lesions in duodenal wall of dogs.
Souza Filho
Zacarias Alves de
ZA
Programa de Pós Graduação em Clínica Cirúrgica, Pontifícia Universidade Católica do Paraná. z.alves@pucpr.br
Greca
Fernando Hintz
FH
Rocha
Sergio Luiz
SL
Ioshii
Sergio Ossamu
SO
Domanski
Ana Carolina
AC
Kfouri
Diogo
D
Campos
Priscila Dall Prá
PD
Silva
Ruy Fernando Kuenzer Caetano da
RF
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004386:Duodenum / Q000293:injuries* / Q000473:pathology; D006648:Histocompatibility; D007413:Intestinal Mucosa / Q000637:transplantation*; D013552:Swine; D014183:Transplantation, Heterologous