Host and virus determinants of picornavirus pathogenesis and tropism.
The family Picornaviridae contains some notable members, including rhinovirus, which infects humans more frequently than any other virus; poliovirus, which has paralysed or killed millions over the years; and foot-and-mouth-disease virus, which led to the creation of dedicated institutes throughout the world. Despite their profound impact on human and animal health, the factors that regulate pathogenesis and tissue tropism are poorly understood. In this article, we review the clinical and economic challenges that these agents pose, summarize current knowledge of host-pathogen interactions and highlight a few of the many outstanding questions that remain to be answered.
Whitton
J Lindsay
JL
Department of Neuropharmacology, CVN-9, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. lwhitton@scripps.edu
Cornell
Christopher T
CT
Feuer
Ralph
R
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D006801:Humans; D010849:Picornaviridae / Q000254:growth & development / Q000472:pathogenicity*; D010850:Picornaviridae Infections / Q000191:economics / Q000503:physiopathology / Q000635:transmission* / Q000821:virology*; D011991:Receptors, Virus / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology; D017735:Virus Latency
D011991:Receptors, Virus; D014764:Viral Proteins