title: Evaluation of surface and build-up region dose for intensity-modulated radiation therapy in head and neck cancer.
abstract: Despite much development, there remains dosimetric uncertainty in the surface and build-up regions in intensity-modulated radiation therapy treatment plans for head and neck cancers. Experiments were performed to determine the dosimetric discrepancies in the surface and build-up region between the treatment planning system (TPS) prediction and experimental measurement using radiochromic film. A head and neck compression film phantom was constructed from two semicylindrical solid water slabs. Treatment plans were generated using two commercial TPSs (PINNACLE3 and CORVUS) for two cases, one with a shallow (approximately 0.5 cm depth) target and another with a deep (approximately 6 cm depth) target. The plans were evaluated for a 54 Gy prescribed dose. For each case, two pieces of radiochromic film were used for dose measurement. A small piece of film strip was placed on the surface and another was inserted within the phantom. Overall, both TPSs showed good agreement with the measurement. For the shallow target case, the dose differences were within +/- 300 cGy (5.6% with respect to the prescribed dose) for PINNACLE3 and +/- 240 cGy (4.4%) for CORVUS in 90% of the region of interest. For the deep target case, the dose differences were +/- 350 (6.5%) for PINNACLE3 and +/- 260 cGy (4.8%) for CORVUS in 90% of the region of interest. However, it was found that there were significant discrepancies from the surface to about 0.2 cm in depth for both the shallow and deep target cases. It was concluded that both TPSs overestimated the surface dose for both shallow and deep target cases. The amount of overestimation ranges from 400 to 1000 cGy (approximately 7.4% to 18.5% with respect to the prescribed dose, 5400 cGy).
authors.affiliation: Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32610, USA.
authors.forename: Heeteak
authors.initials: H
authors.lastname: Chung
authors.forename: Hosang
authors.initials: H
authors.lastname: Jin
authors.forename: James F
authors.initials: JF
authors.lastname: Dempsey
authors.forename: Chihray
authors.initials: C
authors.lastname: Liu
authors.forename: Jatinder
authors.initials: J
authors.lastname: Palta
authors.forename: Tae-Suk
authors.initials: TS
authors.lastname: Suh
authors.forename: Siyong
authors.initials: S
authors.lastname: Kim
mesh_terms: D000465:Algorithms; D001822:Body Burden; D004307:Dose-Response Relationship, Radiation; D005373:Film Dosimetry / Q000379:methods*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity