title: [Neoadjuvant endocrine therapy with anastrozole significantly downstaged an elderly breast cancer woman with locally-advanced breast cancer which became operable].
abstract: A 73-year-old postmenopausal woman had a 13 cm-sized huge tumor in her left breast with an extensive purple skin color change. She had sternal destruction, axillary and supraclavicular lymph node metastases (T4bN3M1, Stage IV). Core needle biopsy showed invasive ductal carcinoma with positive hormone receptor (ER+++, PgR+++). She was treated with 1 mg per day of anastrozole. The tumor decreased in size gradually and became operable after 7.5 months of the anastrozole monotherapy. She underwent mastectomy and axillary node clearance. The resected specimen showed a 3.5 cm sized tumor with significant fibrosis and scanty viable tumor cells. We concluded that neoadjuvant therapy with anastrozole is a good choice for receptor-positive postmenopausal breast cancer, especially for elderly or poor risk women.
authors.affiliation: Dept. of Breast Surgery, Sagara Hospital.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Rai
authors.forename: Mitsutake
authors.initials: M
authors.lastname: Ando
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sagara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takahama
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Matsuyama
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Ooi
authors.forename: Yoshiatsu
authors.initials: Y
authors.lastname: Sagara
mesh_terms: D000368:Aged; D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008408:Mastectomy; D020360:Neoadjuvant Therapy; D009570:Nitriles / Q000627:therapeutic use*; D017698:Postmenopause; D011300:Preoperative Care; D013249:Sternum; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole