title: Serum concentrations of high-sensitivity C-reactive protein predict progressively obstructive lesions rather than late restenosis in patients with unstable angina undergoing coronary artery stenting.
abstract: BACKGROUND
  The present study tested the hypothesis that high-sensitivity C-reactive protein (hs-CRP) concentrations might show significant serial changes in patients with unstable angina (UAP), and that elevation of hs-CRP might indicate a progressively obstructive lesion, rather than late restenosis in such patients undergoing coronary stenting.
  
  
  RESULTS
  Serum concentrations of hs-CRP in 168 patients with UAP undergoing coronary stenting for a new obstructive lesion were prospectively measured (pre-procedure, and on days 21, 90, and 180 post-procedure). The hs-CRP concentrations were also evaluated in 30 at-risk controls and 50 healthy volunteers. Moderately obstructive lesions of non-culprit vessels (defined as > or =50-69% stenosis) that were not treated by coronary angioplasty were found in 107 (63.7%) patients. The hs-CRP concentration was significantly higher at pre-procedure in the study patients than in the controls and healthy volunteers (all p-values <0.0001) and markedly declined after the procedure (p<0.0001). Pre-procedure (p=0.799) and post-procedure hs-CRP concentrations (all p-values >0.1) did not differ between restenotic and non-restenotic patients. However, at pre-procedure or on day 180, the concentration of hs-CRP was independently associated with progressively obstructive lesions of non-culprit vessels that required coronary angioplasty (both p-values <0.05).
  
  
  CONCLUSIONS
  The hs-CRP concentration was significantly higher at pre-procedure and declined substantially thereafter in patients with UAP following coronary stenting. There was no evidence of a positive association between an elevated hs-CRP concentration and late restenosis. However, both the pre-procedure and day 180 concentrations of hs-CRP were strongly associated with the progression of moderately obstructive lesions in non-culprit vessels.
authors.affiliation: Division of Cardiology, Chang Gung Memorial Hospital, Kaohsiung, Republic of China.
authors.forename: Hon-Kan
authors.initials: HK
authors.lastname: Yip
authors.forename: Wei-Chin
authors.initials: WC
authors.lastname: Hung
authors.forename: Cheng-Hsu
authors.initials: CH
authors.lastname: Yang
authors.forename: Yen-Hsun
authors.initials: YH
authors.lastname: Chen
authors.forename: Cheng-I
authors.initials: CI
authors.lastname: Cheng
authors.forename: Shyh-Ming
authors.initials: SM
authors.lastname: Chen
authors.forename: Kuo-Ho
authors.initials: KH
authors.lastname: Yeh
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000150:complications / Q000601:surgery; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology; D023903:Coronary Restenosis / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015607:Stents
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein