Seizure susceptibility in prenatally methamphetamine-exposed adult female rats.
The purpose of the present study was to examine the effect of prenatal methamphetamine (MA) exposure on seizures induced by bicuculline and N-methyl-d-aspartate in adult female rats. The present results show that prenatal MA exposure alters seizures in a model-specific manner and that the seizure susceptibility of adult female rats may be affected by the stage of their estrous cycle.
Slamberová
R
R
Department of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00 Praha 2, Czech Republic.
Rokyta
R
R
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004198:Disease Susceptibility; D030762:Estrous Cycle / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology; D008694:Methamphetamine / Q000494:pharmacology*; D016202:N-Methylaspartate / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D000697:Central Nervous System Stimulants; D018690:Excitatory Amino Acid Agonists; D018756:GABA Antagonists; D008694:Methamphetamine; D016202:N-Methylaspartate; D001640:Bicuculline