Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events.
The effect of breathing 0.1 minimum alveolar concentrations (MAC) of desflurane or isoflurane for three minutes on the incidence of adverse airway events on a subsequent breath of 2 MAC was investigated. Twenty-five volunteers known to develop an adverse airway event to desflurane or isoflurane took part in the study. Each volunteer was exposed to isoflurane and desflurane at least 24 h apart. Volunteers were assessed for adverse airway events while breathing 2 MAC inhalational anaesthetic following breathing 100% O(2) for 3 min. This was repeated with 0.1 MAC inhalational anaesthetic in oxygen instead of 100% O(2). Adverse airway events decreased from 88% to 40% when tests were conducted with desflurane (p = 0.002). With isoflurane, the reduction from 60% to 52% was not statistically significant (p = 0.774). Breathing low concentrations of desflurane decreases the incidence of adverse airway events on subsequent inhalation of higher concentration of desflurane.
Goodwin
N
N
University Hospital of Wales, Heath Park, Cardiff CF14 4XN, Wales, UK.
Strong
P J
PJ
Sudhir
G
G
Wilkes
A R
AR
Hall
J E
JE
D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced; D018592:Cross-Over Studies; D000077335:Desflurane; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced*; D007530:Isoflurane / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008297:Male; D012120:Respiration Disorders / Q000139:chemically induced; D012472:Salivation / Q000187:drug effects; D016037:Single-Blind Method
D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane