title: Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390.
abstract: Starting from 10-deacetylbaccatin III (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy. luciano.barboni@unicam.it
authors.forename: Luciano
authors.initials: L
authors.lastname: Barboni
authors.forename: Roberto
authors.initials: R
authors.lastname: Ballini
authors.forename: Guido
authors.initials: G
authors.lastname: Giarlo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Gabriele
authors.initials: G
authors.lastname: Fontana
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; C459840:IDN 5390; D043823:Taxoids; C404743:IDN 5109