title: Fulminant hepatic failure associated with propylthiouracil: a case report with treatment emphasis on the use of plasmapheresis.
abstract: Propylthiouracil is a commonly used medication for hyperthyroidism. Though propylthiouracil-induced hepatotoxicity is a rarely encountered problem, death due to fulminant hepatic failure may occur. In the English literature, only 34 cases have been described with severe hepatotoxicity secondary to this drug. Here we report a case of fulminant hepatic failure due to propylthiouracil and review the issues of treatment and management with special emphasis on the use of plasmapheresis in such situations.
authors.affiliation: Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey. selimaydemir@hotmail.com
authors.forename: Selim
authors.initials: S
authors.lastname: Aydemir
authors.forename: Yucel
authors.initials: Y
authors.lastname: Ustundag
authors.forename: Taner
authors.initials: T
authors.lastname: Bayraktaroglu
authors.forename: Ishak Ozel
authors.initials: IO
authors.lastname: Tekin
authors.forename: Irfan
authors.initials: I
authors.lastname: Peksoy
authors.forename: Aysun Uroglu
authors.initials: AU
authors.lastname: Unal
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000628:therapy*; D010956:Plasmapheresis; D011441:Propylthiouracil / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil