No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.
OBJECTIVE
We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population.


METHODS
These polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism in patients with chronic heart failure due to idiopathic dilated cardiomyopathy (DCM) and compared with the control group.


RESULTS
There were no differences or any trends in the allele and genotype frequencies of the beta(1)Ser49Gly and beta(1)Arg389Gly polymorphisms. The allele frequency of the alpha(2c)Del322-325 variant was lower in patients than in controls (0.11 vs. 0.04, P = 0.011 < 0.017, by Bonferroni correction), while the genotype frequency just failed to reach significance (P = 0.022 > 0.017, by Bonferroni correction).


CONCLUSIONS
In this population, the variants beta(1)Ser49, beta(1)Arg389, and alpha(2c)Del322-325 do not appear to be risk factors for chronic heart failure due to DCM. The alpha(2c)Del322-325 variant may in fact confer some protection.
Nonen
Shinpei
S
Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Okamoto
Hiroshi
H
Akino
Masatoshi
M
Matsui
Yutaka
Y
Fujio
Yasushi
Y
Yoshiyama
Minoru
M
Takemoto
Yasuhiko
Y
Yoshikawa
Junichi
J
Azuma
Junichi
J
Kitabatake
Akira
A
D000368:Aged; D044466:Asian People / Q000235:genetics*; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D012307:Risk Factors
D018341:Receptors, Adrenergic, alpha-2; D018342:Receptors, Adrenergic, beta-1