title: Erythrokeratoderma variabilis-like ichthyosis in Chanarin-Dorfman syndrome.
abstract: Neutral lipid storage disease (Chanarin-Dorfman syndrome) is an autosomal recessive metabolic disorder associated with congenital ichthyosis and a multisystemic accumulation of neutral lipids (lipid droplets) in various types of cells. The clinical presentation has been reported to correspond to that of nonbullous congenital ichthyosiform erythroderma. We report a 4-year-old boy presenting a generalized ichthyosiform disorder manifested by migrating scaly plaques alternating with areas of normal-looking skin, showing erythematous borders with sharp margins, clinically suggestive of erythrokeratoderma variabilis (EKV). A peripheral blood smear revealed cytoplasmic vacuoles in most granulocytes. Genetic studies from the patient and his parents revealed that the patient carried two different and novel mutations of the ABHD5 gene: a nonsense mutation in exon 6 (transmitted by the father) and an insertion/deletion in exon 4 (transmitted by the mother). Our observation demonstrates the clinical heterogeneity of the ichthyosiform dermatoses observed in Chanarin-Dorfman syndrome and widens the clinical range of conditions presenting migrating scaly plaques mimicking EKV.
authors.affiliation: Pathology, Hospital del Mar, IMAS, Passeig Maritim 25-29, 08003 Barcelona, Spain. rpujol@imas.imim.es
authors.forename: R M
authors.initials: RM
authors.lastname: Pujol
authors.forename: M
authors.initials: M
authors.lastname: Gilaberte
authors.forename: A
authors.initials: A
authors.lastname: Toll
authors.forename: L
authors.initials: L
authors.lastname: Florensa
authors.forename: J
authors.initials: J
authors.lastname: Lloreta
authors.forename: M A
authors.initials: MA
authors.lastname: González-Enseñat
authors.forename: J
authors.initials: J
authors.lastname: Fischer
authors.forename: A
authors.initials: A
authors.lastname: Azon
mesh_terms: D051103:1-Acylglycerol-3-Phosphate O-Acyltransferase; D002675:Child, Preschool; D004950:Esterases / Q000235:genetics; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000235:genetics / Q000473:pathology*; D008049:Lipase / Q000235:genetics; D008052:Lipid Metabolism, Inborn Errors / Q000235:genetics / Q000473:pathology*; D008297:Male; D009154:Mutation; D013577:Syndrome; D014617:Vacuoles / Q000473:pathology
chemical_list: D051103:1-Acylglycerol-3-Phosphate O-Acyltransferase; C439972:ABHD5 protein, human; D004950:Esterases; D008049:Lipase