title: Successful treatment of localized cutaneous infection caused by Mycobacterium scrofulaceum with clarithromycin.
abstract: Cutaneous infection arising from Mycobacterium scrofulaceum, a nontuberculous mycobacteria, has rarely been reported, and most of the reported infections were disseminated forms in patients with AIDS or other immunocompromising illness. We describe an occurrence of localized mycobacterial skin infection caused by M. scrofulaceum in a previously healthy child that manifested as a red nodule on the cheek. A biopsy specimen of the lesion demonstrated granulomatous infiltration in the dermis. M. scrofulaceum was isolated from culture of a tissue specimen. Polymerase chain reaction amplified specific fragments for M. scrofulaceum. The patient was treated successfully with clarithromycin as monotherapy for 6 months, leading to complete healing without recurrence during a follow-up period of 2 years.
authors.affiliation: Department of Dermatology, College of Medicine, Pusan National University, Seo-gu, Busan, Korea. hsjang@pusan.ac.kr
authors.forename: Ho-Sun
authors.initials: HS
authors.lastname: Jang
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Jo
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Oh
authors.forename: Moon-Bum
authors.initials: MB
authors.lastname: Kim
authors.forename: Jae-Bong
authors.initials: JB
authors.lastname: Lee
authors.forename: Chulhun L
authors.initials: CL
authors.lastname: Chang
authors.forename: Yoo-Wook
authors.initials: YW
authors.lastname: Kwon
authors.forename: Kyung-Sool
authors.initials: KS
authors.lastname: Kwon
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D017291:Clarithromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications / Q000188:drug therapy*; D015359:Mycobacterium scrofulaceum / Q000302:isolation & purification*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin