title: Computed tomography severity index is an early prognostic tool for acute pancreatitis.
abstract: BACKGROUND
  Acute pancreatitis is a severe disease with unpredictable course and outcomes. It is especially hard to identify early those patients who will have a fulminant course. In a prospective observational study, we tested the hypothesis that the CT Severity Index (CTSI), established within 48hours after admission, is prognostic for morbidity and mortality and can predict the necessity for admission to an ICU.
  
  
  METHODS
  From January 1994 to October 2002, all patients with the diagnosis of first time acute pancreatitis underwent spiral CT with intravenous contrast within 48hours of admission. The extent of inflammation and necrosis was assessed to define the CTSI. Patients were initially managed in an ICU in a standardized fashion. Complications and mortality were registered in a systematic manner.
  
  
  RESULTS
  Seventy-nine patients were admitted with acute pancreatitis. The overall complication rate was 57%; mortality was 9%. In patients with a CTSI of 0 to 3, these rates were 42% and 2%, respectively; in those with CTSI of 4 to 6, 81% and 19%, respectively; and in those with CTSI of 7 to 10, 100% and 33%, respectively. Outcomes of subsequent CT scans did not alter the initial prognosis. Early CTSI correlated well with the incidence of complications, sepsis, mortality, and necessity for ICU admission.
  
  
  CONCLUSIONS
  Acute pancreatitis is associated with marked morbidity and mortality. Initial admission to an ICU and standardized conservative treatment are justified for all patients. Early establishment of the CTSI is an excellent prognostic tool for complications and mortality. Patients with a CTSI of 0 to 3 can safely be discharged from the ICU.
authors.affiliation: Department of Surgery, Rode Kruis Ziekenhuis, The Hague, The Netherlands.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Vriens
authors.forename: Pieter
authors.initials: P
authors.lastname: van de Linde
authors.forename: Eveline T
authors.initials: ET
authors.lastname: Slotema
authors.forename: Piet E
authors.initials: PE
authors.lastname: Warmerdam
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Breslau
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D011446:Prospective Studies; D012720:Severity of Illness Index; D036542:Tomography, Spiral Computed
chemical_list: D003287:Contrast Media