title: The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides.
abstract: Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(fluoromethyl)purine ribonucleoside displayed significant cytostatic effects.
authors.affiliation: Centre for New Antivirals and Antineoplastics, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Silhár
authors.forename: Radek
authors.initials: R
authors.lastname: Pohl
authors.forename: Ivan
authors.initials: I
authors.lastname: Votruba
authors.forename: Michal
authors.initials: M
authors.lastname: Hocek
mesh_terms: D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D058892:Adenosine Deaminase Inhibitors; D000970:Antineoplastic Agents; D011684:Purine Nucleosides; D011687:Purines