title: Model studies for the synthesis of galbonolide B.
abstract: The construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of has been constructed using an ester enolate rearrangement/silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/mercury assisted ring closure protocol.
authors.affiliation: Pfizer Pharmaceuticals Limited, Sandwich, Kent, CT13 9NJ, UK.
authors.forename: James
authors.initials: J
authors.lastname: Eshelby
authors.forename: Matthias
authors.initials: M
authors.lastname: Goessman
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Parsons
authors.forename: Lewis
authors.initials: L
authors.lastname: Pennicott
authors.forename: Adrian
authors.initials: A
authors.lastname: Highton
mesh_terms: D007783:Lactones / Q000138:chemical synthesis
chemical_list: D007783:Lactones; C047787:neorustmicin A