title: Monoterpene lactones from the seeds of Nephelium lappaceum.
abstract: Dichloromethane extracts of the seeds of Nephelium lappaceum afforded two new diastereomeric monoterpene lactones, 1 and 2, and the known butenolide siphonodin (3), as well as kaempferol 3-O-beta-D-glucopyranoside-7-O-alpha-L-rhamnopyranoside. Compounds 1 and 2 represent a new monoterpene skeleton, and their structures were elucidated by extensive 1D and 2D NMR spectral data interpretation. Antimicrobial testing was carried out on 1 and 2 against a panel of bacteria and fungi.
authors.affiliation: Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila, 1004, Philippines. ragasac@dlsu.edu.ph
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
authors.forename: Roderick D
authors.initials: RD
authors.lastname: de Luna
authors.forename: Wilfredo C
authors.initials: WC
authors.lastname: Cruz
authors.forename: John A
authors.initials: JA
authors.lastname: Rideout
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D029631:Sapindaceae / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007783:Lactones; D039821:Monoterpenes; C505312:lappaceolide A; C505313:lappaceolide B