title: [The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum].
abstract: OBJECTIVE
  To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.
  
  
  METHODS
  Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.
  
  
  RESULTS
  The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).
  
  
  CONCLUSIONS
  HPCD is an ideal solubilizer for paeonolum.
authors.affiliation: The Second Hospital, China Medical University, Shenyang 110004, China.
authors.forename: Ling-Yan
authors.initials: LY
authors.lastname: Jian
authors.forename: Yue-Hui
authors.initials: YH
authors.lastname: Yang
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Xu
authors.forename: Zhong-Gui
authors.initials: ZG
authors.lastname: He
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000098:Acetophenones / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D004355:Drug Stability; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D047392:beta-Cyclodextrins
chemical_list: D000098:Acetophenones; D005079:Excipients; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C013638:paeonol