title: Hypocalcemia due to tubular dysfunction in a patient with holoprosencephaly.
abstract: This is the first report of a case of hypocalcemia in a female infant with holoprosencephaly. Hypocalcemia developed 60 days after birth, secondary to decreased serum 1,25-dihydroxyvitamin D, as a result of renal tubular dysfunction which may have been induced by prerenal acute renal failure, the administration of anticonvulsants, and hypothyroidism. However, there was no evidence of rickets, and her serum 25-hydroxyvitamin D value was normal. She was treated with high-dose (0.5 microg/kg) 1alpha-hydroxyvitamin D3 and calcium lactate, and her calcium and 1,25-dihydroxyvitamin D values were consequently, normalized. However, she died at 268 days after birth.
authors.affiliation: Department of Pediatrics, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
authors.forename: Masaho
authors.initials: M
authors.lastname: Negishi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kano
authors.forename: Naoto
authors.initials: N
authors.lastname: Shimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Arisaka
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects; D002117:Calcitriol / Q000097:blood; D020790:Diabetes Insipidus, Neurogenic / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D016142:Holoprosencephaly / Q000150:complications*; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn
chemical_list: D000927:Anticonvulsants; D002117:Calcitriol