title: Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000.
abstract: We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G --> A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (-514 --> CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.
authors.affiliation: Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara-cho, Shogoin, Sakuo-ku, Kyoto 606-8507, Japan. harai@kuhp.kyoto-u.ac.jp
authors.forename: Hidenori
authors.initials: H
authors.lastname: Arai
authors.forename: Akira
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yamada
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mabuchi
authors.forename: Tamio
authors.initials: T
authors.lastname: Teramoto
authors.forename: Jun
authors.initials: J
authors.lastname: Sasaki
authors.forename: Noriaki
authors.initials: N
authors.lastname: Nakaya
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Itakura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Ouchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Horibe
authors.forename: Tohru
authors.initials: T
authors.lastname: Egashira
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hattori
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shirahashi
authors.forename: Toru
authors.initials: T
authors.lastname: Kita
mesh_terms: D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008049:Lipase / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics*; D008071:Lipoprotein Lipase / Q000235:genetics; D008297:Male; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood / Q000235:genetics*
chemical_list: D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D006023:Glycoproteins; C504173:LIPC protein, human; D014280:Triglycerides; D008049:Lipase; D008071:Lipoprotein Lipase