A novel cytogenetic abnormality in Burkitt lymphoma associated with treatment resistant disease.
We present a patient with deletion of IgH associated with the reciprocal translocation (8;14) in Burkitt lymphoma. The patient had treatment resistant disease and died 10 weeks after diagnosis. The deletion was detected by fluorescence in situ hybridization at diagnosis and again after failure of chemotherapy. To our knowledge this is the first report of such a deletion.
Durrant
E
E
Department of Haematology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, NSW, Australia.
Durant
E
E
Diaz
S
S
Greenaway
S
S
Smith
A
A
D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D020732:Cytogenetic Analysis; D017809:Fatal Outcome; D017353:Gene Deletion; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D017211:Treatment Failure
D007143:Immunoglobulin Heavy Chains