[The changes and their clinical significance of D-dimer and platelet glycoprotein in patients with coronary heart disease].
OBJECTIVE
To explore the changes and their clinical significance of D-dimer and platelet glycoprotein (GP) in patients with coronary heart disease.


METHODS
D-dimer and GP in 20 patients with stable angina (SA group), 48 patients with unstable angina (UA group), and 20 control cases were measured. The changes of D-dimer and GP in patients with and without coronary events were compared. The sensitivity of those changes in the diagnosis of coronary events was evaluated.


RESULTS
There were significant differences of D-dimer and GP between UA group and SA group or control group (P < 0.01), while there was no significant difference between SA group and control group (P > 0.05). There were also significant differences of D-dimer and GP between patients with coronary events and patients without coronary events (P < 0.05). In the sensitivity test for detecting coronary events, D-dimer and GPIIb, GPIIIa were much more sensitive than other parameters.


CONCLUSIONS
D-dimer and GPIIb, GPIIIa may be regarded as the indexes of coronary thrombosis and used for predicting the severity of coronary events.
Ma
Jian-lin
JL
Department of Cardiology, People's of Hainan provincial hospital, Hainan 570311, China.
Wang
Sheng
S
Li
Xin-ming
XM
Su
Zhe-tan
ZT
Li
Bin
B
Chen
Guan-liang
GL
Li
Jin
J
Wang
Wei
W
D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis / Q000378:metabolism; D016022:Case-Control Studies; D003327:Coronary Disease / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000378:metabolism; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D040201:Platelet Membrane Glycoprotein IIb / Q000378:metabolism; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D040201:Platelet Membrane Glycoprotein IIb; D010980:Platelet Membrane Glycoproteins