title: [Effects of prolonged selenium deficiency on synaptic structures in CA3 area of hippocampus in the third generation rats].
abstract: OBJECTIVE
  The relationship between selenium deficiency and the changes of synaptic structure in the CA3 area of hippocampus were studied in the third generation rats.
  
  
  METHODS
  A selenium deficiency model was established by feeding rats with selenium-deficient food. The rats were divided into 4 groups: control (Se+I+), selenium deficiency (Se-I+), iodine deficiency (Se+I-), and both deficient group (Se-I-). The hippocampuses were dissected from the third generation rats on the 21st gestational day and the ultrastructural features of hippocampal synapses were observed with electron microscope. The length of active zone, synaptic curvatures, post-synaptic density (PSD) and synaptic cleft were quantitatively described.
  
  
  RESULTS
  Compared with the control, the length of active zone and the thickness of PSD were significantly decreased in Se-I+, Se+I- and Se-I- groups [(261.7 +/- 50.1) nm, (286.7 +/- 41.6) nm and (220.8 +/- 61.6) nm contrast to (312.4 +/- 47.7) nm, P < 0.01], so were the synaptic curvatures in Se-I+, Se+I- and Se-I- groups [(22.9 +/- 6.3) nm, (27.5 +/- 8.6) nm and (25.2 +/- 6.5) nm contrast to (48.1 +/- 12.3) nm, P < 0.01]; the width of synaptic cleft were also decreased significantly in Se-I- [(11.1 +/- 3.3) nm contrast to (16.1 +/- 4.0) nm, P < 0.01].
  
  
  CONCLUSIONS
  Selenium deficiency might cause changes of neuronal functions at the synaptic level, and furthermore, affect learning and memory.
authors.affiliation: Department of Pathology, Shantou University Medical College, Shantou 515041, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Su
authors.forename: Dong-Ping
authors.initials: DP
authors.lastname: Tian
mesh_terms: D000818:Animals; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D007455:Iodine / Q000172:deficiency; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000172:deficiency*; D013569:Synapses / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D007455:Iodine; D012643:Selenium