title: Y-SNP-genotyping - a new approach in forensic analysis.
abstract: Y-chromosomal DNA polymorphisms, especially Y-STRs are well established in forensic routine case work. The STRs are used for identification in paternity deficiency cases and stain analysis with complicate mixtures of male and female DNA. In contrast, Y-chromosomal SNPs are a new tool in forensic investigations. At present, Y-SNPs are mainly used in molecular anthropology for evolutionary studies. Nevertheless, these markers could also provide very useful information for the analysis of forensic cases. The aim of the presented study was to test Y-SNP-typing for stain analyses using different methods-SNaPshot and MALDI-TOF MS. Both methods are based on the principle of minisequencing. The selected Y-SNP markers are suited to define the most important European haplogroups.
authors.affiliation: Institute of Legal Medicine, University of Leipzig, Germany. Ruediger.Lessig@medizin.uni-leipzig.de
authors.forename: R
authors.initials: R
authors.lastname: Lessig
authors.forename: M
authors.initials: M
authors.lastname: Zoledziewska
authors.forename: K
authors.initials: K
authors.lastname: Fahr
authors.forename: J
authors.initials: J
authors.lastname: Edelmann
authors.forename: M
authors.initials: M
authors.lastname: Kostrzewa
authors.forename: T
authors.initials: T
authors.lastname: Dobosz
authors.forename: W J
authors.initials: WJ
authors.lastname: Kleemann
mesh_terms: D041322:Chromosomes, Human, Y; D004247:DNA / Q000032:analysis; D016172:DNA Fingerprinting / Q000379:methods*; D017931:DNA Primers; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: D017931:DNA Primers; D005819:Genetic Markers; D004247:DNA