title: A novel synthetic adjuvant effectively enhances the immunogenicity of the influenza vaccine.
abstract: Influenza vaccination is a key intervention to reduce morbidity and mortality provoked by this disease. To date, the challenge of improving its efficacy remains unmet. The immunogenic synthetic peptide GK1 from Taenia crassiceps cysticerci was tested herein in its capacity as adjuvant, co-administered with the inactivated anti-influenza vaccine before and after challenge with influenza virus in both young and aged mice. Co-administration of GK1 with the influenza vaccine increased levels of anti-influenza antibodies in aged mice before and after infection, reduced the local inflammation that accompanied influenza vaccination itself and favored virus clearance after infection in both young and aged mice.
authors.affiliation: Instituto de Investigaciones Biomédicas, A.P. 70228, Ciudad Universitaria, 04510 México, D.F., México.
authors.forename: R
authors.initials: R
authors.lastname: Segura-Velázquez
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Torres
authors.forename: G
authors.initials: G
authors.lastname: Rosas
authors.forename: A
authors.initials: A
authors.lastname: Toledo
authors.forename: M
authors.initials: M
authors.lastname: Restelli
authors.forename: E
authors.initials: E
authors.lastname: Acosta
authors.forename: R
authors.initials: R
authors.lastname: Corral
authors.forename: F
authors.initials: F
authors.lastname: Rosetti
authors.forename: G
authors.initials: G
authors.lastname: Fragoso
authors.forename: S
authors.initials: S
authors.lastname: Grinstein
authors.forename: E
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007252:Influenza Vaccines / Q000276:immunology*; D008168:Lung / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D010455:Peptides; D012503:Saponins; D000536:Aluminum Hydroxide