title: Simultaneous correction of the influence of skin color and fat on tissue spectroscopy by use of a two-distance fiber-optic probe and orthogonalization technique.
abstract: We have demonstrated simultaneous correction for the optical interference of skin and fat in tissue spectra by using a two-distance fiber-optic probe. We obtained the correction by orthogonalizing the spectra collected at a long source-detector distance (SD) to the spectra collected at a short SD and mapped to the long SD space. The method was validated in tissuelike three-layer phantoms as well as preliminarily in human tissue. After the correction, a partial-least-squares model of the phantoms showed enhanced prediction performance.
authors.affiliation: Department of Anesthesiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA. ye.yang@umassmed.edu
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Landry
authors.forename: Olusola O
authors.initials: OO
authors.lastname: Soyemi
authors.forename: Michael A
authors.initials: MA
authors.lastname: Shear
authors.forename: Dulce S
authors.initials: DS
authors.lastname: Anunciacion
authors.forename: Babs R
authors.initials: BR
authors.lastname: Soller
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry* / Q000502:physiology; D000465:Algorithms; D016477:Artifacts; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D018482:Muscle, Skeletal / Q000737:chemistry* / Q000502:physiology; D055100:Optical Fibers; D019047:Phantoms, Imaging; D010865:Pilot Projects; D012880:Skin Pigmentation / Q000502:physiology*; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation* / Q000379:methods*; D014159:Transducers