Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet.
This study aims to assess whether or not a methanol extract of Momordica charantia is able to normalise lipid and glucose levels in diabetic rats fed a high-fat and a low-carbohydrate diet. Different doses of the extract are administered orally for 45 days. The rats are bled at the beginning of the experiment and at 15-day intervals. Blood glucose, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and cholesterol are estimated. Results showed that M. charantia extract normalised blood glucose level, reduced triglyceride and LDL levels and increased HDL level. The animals reverted to a diabetic state once the M. charantia extract was discontinued.
Chaturvedi
P
P
Department of Biological Sciences, University of Botswana, P/Bag 0074 Gaborone, Botswana. chaturve@mopipi.ub.bw
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D029777:Momordica charantia; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol