An efficient kinetic resolution of racemic Betti base based on an enantioselective N,O-deketalization.
An efficient kinetic resolution of racemic Betti base with L-(+)-tartaric acid in acetone was developed based on a novel enantioselective N,O-deketalization, by which the enantiopure R- and S-enantiomers of Betti base were obtained as the corresponding N,O-ketal compound and salt with L-(+)-tartaric acid, respectively, in excellent yields with a practically foolproof operation.
Dong
Yanmei
Y
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Li
Rui
R
Lu
Jun
J
Xu
Xuenong
X
Wang
Xinyan
X
Hu
Yuefei
Y