[The composition and drug sensitivity of a mycobacterial population in patients with suspected tuberculosis].
By using the diagnostic material (175 sputum samples and 103 bronchoalveolar lavage fluid samples) taken from 39 patients with suspected tuberculous infection during a 2.5-month follow-up, the authors traced the time course of changes in the composition and drug sensitivity of a mycobacterial population to rifampicin. Along with the traditional microbiological studies, the latest molecular biological studies, a TB-BIOCHIP test system (enzyme immunoassay) in particular, were employed to detect the bacterial and L-transformed forms of the causative agent. A molecular biological assay was first developed to detect the drug sensitivity of L-forms of Mycobacterium tuberculosis.
Dorozhkova
I R
IR
Badleeva
M V
MV
Skotnikova
O I
OI
Nosova
E Iu
EIu
Kupavtseva
E A
EA
Borisov
S E
SE
Moroz
A M
AM
D000904:Antibiotics, Antitubercular / Q000494:pharmacology*; D001992:Bronchoalveolar Lavage Fluid; D016009:Chi-Square Distribution; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007740:L Forms / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification*; D012293:Rifampin / Q000494:pharmacology*; D013183:Sputum / Q000382:microbiology; D013997:Time Factors
D000904:Antibiotics, Antitubercular; D012293:Rifampin