title: Allele and genotype frequencies of CYP2C9 in a Korean population.
abstract: OBJECTIVE
  To determine the frequencies of the variant alleles and the genotypes of CYP2C9 in a Korean population.
  
  
  METHODS
  Three hundred and fifty-eight healthy Korean subjects were studied. CYP2C9 alleles were detected by polymerase chain reaction-restriction fragment length polymorphism assays and direct sequencing assays.
  
  
  RESULTS
  The allele frequencies were 0.934 for CYP2C9*1, 0.060 for CYP2C9*3 and 0.006 for CYP2C9*13. The CYP2C9*2,*4,*5 and *11 alleles were not detected. The frequencies of the CYP2C9*1/*1, *1/*3 and *1/*13 genotypes were 0.869, 0.120 and 0.011, respectively.
  
  
  CONCLUSIONS
  The frequency of the CYP2C9*3 allele in the Korean population studied was significantly higher than reported elsewhere, and a novel allele, CYP2C9*13, was found at a frequency of 0.006 (95% confidence interval 0, 0.012). Only three genotypes of CYP2C9, CYP2C9*1/*1,*1/*3 and *1/*13 were observed in this Korean population.
authors.affiliation: Laboratory of Pharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Bae
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Sang-In
authors.initials: SI
authors.lastname: Yang
authors.forename: Mi-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Choon-Gon
authors.initials: CG
authors.lastname: Jang
authors.forename: Young-Seo
authors.initials: YS
authors.lastname: Park
authors.forename: Seok-Yong
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases