title: Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis.
abstract: To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), beta-funaltrexamine (beta-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (kappa-receptor antagonist) and beta-FNA (mu-receptor antagonist), while NTI (delta-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of mu-, kappa-receptors and adenosine-receptor.
authors.affiliation: Seiwa Pharmaceutical, Ltd; 187-11 Usuba, Hanakawa-machi, Kitaibaraki, Ibaraki 319-1535, Japan. chi-59@unimatec.co.jp
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chi
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Toyokichi
authors.initials: T
authors.lastname: Yoshizawa
authors.forename: Xi-Ying
authors.initials: XY
authors.lastname: Zhao
authors.forename: Wen-Mei
authors.initials: WM
authors.lastname: Yan
authors.forename: Fumio
authors.initials: F
authors.lastname: Hashimoto
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
authors.forename: Shinobu
authors.initials: S
authors.lastname: Sakurada
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D039821:Monoterpenes / Q000494:pharmacology*; D009271:Naltrexone / Q000008:administration & dosage / Q000031:analogs & derivatives; D009292:Narcotic Antagonists; D058915:Purinergic P1 Receptor Antagonists
chemical_list: D000470:Alkaloids; D000700:Analgesics; D039821:Monoterpenes; D009292:Narcotic Antagonists; D058915:Purinergic P1 Receptor Antagonists; C400141:incarvillateine; C051844:norbinaltorphimine; D009271:Naltrexone; C024524:beta-funaltrexamine; C055382:naltrindole