Whole genome linkage scan of recurrent depressive disorder from the depression network study.
Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.
McGuffin
Peter
P
Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK. p.mcguffin@iop.kcl.ac.uk
Knight
Jo
J
Breen
Gerome
G
Brewster
Shyama
S
Boyd
Peter R
PR
Craddock
Nick
N
Gill
Mike
M
Korszun
Ania
A
Maier
Wolfgang
W
Middleton
Lefkos
L
Mors
Ole
O
Owen
Michael J
MJ
Perry
Julia
J
Preisig
Martin
M
Reich
Theodore
T
Rice
John
J
Rietschel
Marcella
M
Jones
Lisa
L
Sham
Pak
P
Farmer
Anne E
AE
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002874:Chromosome Mapping; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D012008:Recurrence; D018433:Twin Studies as Topic