Febrile nonhaemolytic transfusion reaction caused by antibodies against human platelet antigen 5a.
Anti-human platelet antigens (HPA) alloantibodies are seldom involved in febrile nonhaemolytic reactions (FNHTRs). We describe a case in which anti-HPA-5a alloantibodies are related to an FNHTR. We studied the specificity of the alloantibodies by flow cytometry, ELISA and MACE. Typing of donors and the patient was performed by sequence-specific polymerase chain reaction. The alloantibodies were found reactive with HPA-5a antigens. The patient was HPA-5b/b, whereas the donor of the platelet apheresis involved in the FNHTR was HPA-5a/a. Despite the low frequency of anti-HPA-5a antibodies, they might be responsible for FNHTR.
Tazzari
P L
PL
Immunohematology and Transfusion Medicine Service, Azienda Ospedaliera S.Orsola-Malpighi, Bologna, Italy.
Bontadini
A
A
Zamagni
C
C
Ricci
F
F
Fruet
F
F
Iannelli
S
S
Conte
R
R
D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology; D001782:Blood Donors; D005260:Female; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000235:genetics / Q000276:immunology; D017713:Platelet Transfusion / Q000009:adverse effects / Q000379:methods; D013921:Thrombocytopenia / Q000628:therapy
C071092:5a alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies