In vitro activities of doripenem and comparator agents against 364 anaerobic clinical isolates.
The in vitro activities of doripenem against 364 anaerobic isolates were measured and compared to those of ertapenem, imipenem, meropenem, ceftriaxone, and levofloxacin. All of the carbapenems were active against nearly all Bacteroides fragilis group isolates. Doripenem was either comparable to or slightly less active than imipenem and meropenem against most isolates but more active than the other penems against Clostridium difficile. Doripenem appears to have excellent activity against a broad range of anaerobes.
Wexler
Hannah M
HM
Medical and Research Services, Greater Los Angeles Veterans Administration Health Care Services, California, USA. hwexler@ucla.edu
Engel
Adrian E
AE
Glass
Daniel
D
Li
Calida
C
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D000077727:Ertapenem; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D064704:Levofloxacin; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D047090:beta-Lactams; D064704:Levofloxacin; D015378:Imipenem; D015242:Ofloxacin; D000077726:Doripenem; D000077731:Meropenem; D000077727:Ertapenem