Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant phenotypes.
The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by < or =2 microg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.
von Eiff
Christof
C
Institute of Medical Microbiology, University of Münster Hospital and Clinics, Germany. eiffc@uni-muenster.de
Friedrich
Alexander W
AW
Becker
Karsten
K
Peters
Georg
G
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D024841:Fluoroquinolones; D014644:Genetic Variation; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D023303:Oxazolidinones / Q000494:pharmacology; D010641:Phenotype; D011804:Quinolines / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000081:Acetamides; D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D002511:Cephalosporins; D024841:Fluoroquinolones; D023303:Oxazolidinones; D011804:Quinolines; C443755:ceftobiprole; D000069349:Linezolid; D002444:Cefuroxime; D000077266:Moxifloxacin