title: Ten novel HLA-DRB1 alleles and one novel DRB3 allele.
abstract: Ten novel HLA-DRB1 and one DRB3 alleles are described. Eight of the variants are single-nucleotide substitutions, four resulting in an amino acid change (DRB1*1145, *1148, *0828 and *1514) and four with silent substitutions (DRB1*040504, *130103, *160502 and DRB3*020204). Two alleles differ by two nucleotide changes altering one (DRB1*1447 and *1361) amino acid and one allele alters three nucleotides and two amino acids.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Lazaro
authors.forename: N K
authors.initials: NK
authors.lastname: Steiner
authors.forename: M E
authors.initials: ME
authors.lastname: Moraes
authors.forename: J R
authors.initials: JR
authors.lastname: Moraes
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: R J
authors.initials: RJ
authors.lastname: Hartzman
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D006801:Humans; D009154:Mutation
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains