title: Serum levels of soluble P-selectin are increased and associated with disease activity in patients with Behçet's syndrome.
abstract: Behçet's syndrome (BS) is a relapsing, chronic, inflammatory disease characterized by endothelial dysfunction, atherothromboembogenesis, and leukocytoclastic vasculitis with complex immunologic molecular interactions. Generalized derangements of the lymphocyte and neutrophil populations, activated monocytes, and increased PMNLs motility with upregulated cell surface molecules such as ICAM-1, VCAM-1, and E-selectin, which are found on the endothelial cells, leukocytes, and platelets, have all been demonstrated during the course of BS. Our aim is to investigate the association of serum concentrations of soluble P-selectin in patients with BS, and to evaluate whether disease activity has an effect on their blood levels. This multicenter study included 31 patients with BS (15 men and 16 women) and 20 age- and sex-matched healthy control volunteers (11 men and nine women). Neutrophil count, erythrocyte sedimentation rate, and acute-phase reactants as well as soluble P-selectin levels were determined. The mean age and sex distributions were similar (P > .05) between BS patients (35 years) and control volunteers (36 years). Serum levels of soluble P-selectin in patients with BS (399 +/- 72 ng/mL) were significantly (P < .001) higher when compared with control subjects (164 +/- 40 ng/mL). In addition, active BS patients (453 +/- 37 ng/mL) had significantly (P < .001) elevated levels of soluble P-selectin than those in inactive period (341 +/- 52 ng/mL). This study clearly demonstrated that serum soluble P-selectin levels are increased in BS patients when compared with control subjects, suggesting a modulator role for soluble P-selectin during the course of platelet activation and therefore, atherothrombogenesis formation in BS, especially in active disease.
authors.affiliation: Department of Biochemistry, Inönü University Medical Faculty, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Turkoz
authors.forename: Cem
authors.initials: C
authors.lastname: Evereklioglu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozkiriş
authors.forename: Selçuk
authors.initials: S
authors.lastname: Mistik
authors.forename: Murat
authors.initials: M
authors.lastname: Borlu
authors.forename: Ibrahim H
authors.initials: IH
authors.lastname: Ozerol
authors.forename: Fuat
authors.initials: F
authors.lastname: Duygulu
authors.forename: Ozgür
authors.initials: O
authors.lastname: Ilhan
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D002908:Chronic Disease; D017700:Embolism, Cholesterol / Q000097:blood* / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000473:pathology; D007962:Leukocytes / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation; D013577:Syndrome; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D015815:Cell Adhesion Molecules; D019007:P-Selectin