title: Phelligridimer A, a highly oxygenated and unsaturated 26-membered macrocyclic metabolite with antioxidant activity from the fungus Phellinus igniarius.
abstract: [structure: see text] A highly oxygenated and unsaturated 26-membered macrocyclic metabolite, phelligridimer A (1), has been isolated from the Chinese medicinal fungus Phellinus igniarius. Its structure was elucidated by spectroscopic methods. A possible biogenesis of 1 mediated by the fungal metabolite hispidin was postulated. Phelligridimer A showed antioxidant activity (IC50 of 10.2 microM) but was inactive to several human cancer cell lines (IC50 > 50 microM) and enzymes PTP1B (IC50 > 25 microM) and thrombin (IC50 > 10 microM).
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Wang
authors.forename: Shun-Yan
authors.initials: SY
authors.lastname: Mo
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D047028:Macrocyclic Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D008958:Models, Molecular; D015394:Molecular Structure; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
chemical_list: D000975:Antioxidants; D047028:Macrocyclic Compounds; D011753:Pyrones; C512234:phelligridimer A; D017027:Protein Tyrosine Phosphatases