title: [Lysosomal membrane glycoprotein lamp2a--receptor for chaperone-mediated degradation of cytosolic proteins].
abstract: The structure of several lysosomal membrane glycoproteins (lamp1, lamp2, limpI and limpII) has been described. The significance of the receptor glycoprotein lamp2a in the chaperone-mediated autophagy of cytosolic proteins with KFERQ motif has been described in details as well as the chaperone protein Hsc73 and other chaperones involved in this process. Several modulatory mechanisms of the chaperone-mediated autophagy, which is activated in condition of stress and starvation, were also outlined.
authors.affiliation: Department of Biochemistry, Institute of General and Molecular Biology, Nicolaus Copernicus University, 7 Gagarin St., 87-100 Torun, Poland. kroszek@biol.uni.torun.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Roszek
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Gniot-Szulzycka
mesh_terms: D003600:Cytosol / Q000378:metabolism*; D006801:Humans; D052118:Lysosomal-Associated Membrane Protein 1 / Q000378:metabolism; D052119:Lysosomal-Associated Membrane Protein 2 / Q000378:metabolism*; D051907:Lysosomal Membrane Proteins / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D051116:Receptors, Scavenger; D012795:Sialoglycoproteins / Q000378:metabolism
chemical_list: D052118:Lysosomal-Associated Membrane Protein 1; D052119:Lysosomal-Associated Membrane Protein 2; D051907:Lysosomal Membrane Proteins; D018832:Molecular Chaperones; D051116:Receptors, Scavenger; C074299:SCARB2 protein, human; D012795:Sialoglycoproteins