title: Prostate cancer risk among men with diabetes mellitus (Spain).
abstract: OBJECTIVE
  Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.
  
  
  METHODS
  Population based case-control study nested in a cohort.
  
  
  RESULTS
  We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.
  
  
  CONCLUSIONS
  Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
authors.affiliation: Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain. agonzalez@ceife.es
authors.forename: A
authors.initials: A
authors.lastname: González-Pérez
authors.forename: L A
authors.initials: LA
authors.lastname: García Rodríguez
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D019992:Databases as Topic; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005194:Family Practice; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D012306:Risk; D018570:Risk Assessment; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D007004:Hypoglycemic Agents