title: Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.
abstract: The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.
authors.affiliation: University of Kiel, Institute of Biochemistry, Kiel, Germany. eeva-liisa.eskelinen@helsinki.fi
authors.forename: Eeva-Liisa
authors.initials: EL
authors.lastname: Eskelinen
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Cuervo
authors.forename: Matthew R G
authors.initials: MR
authors.lastname: Taylor
authors.forename: Ichizo
authors.initials: I
authors.lastname: Nishino
authors.forename: Janice S
authors.initials: JS
authors.lastname: Blum
authors.forename: J Fred
authors.initials: JF
authors.lastname: Dice
authors.forename: Ignacio V
authors.initials: IV
authors.lastname: Sandoval
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lippincott-Schwartz
authors.forename: J Thomas
authors.initials: JT
authors.lastname: August
authors.forename: Paul
authors.initials: P
authors.lastname: Saftig
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D030541:Databases, Genetic; D006801:Humans; D008247:Lysosomes / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D009626:Terminology as Topic
chemical_list: D020033:Protein Isoforms