title: Evolution of treatment strategies in chronic lymphocytic leukemia. Part 2 of a 3-Part series: Advances in the treatment of hematologic malignancies.
abstract: Over the past few decades, the management of chronic lymphocytic leukemia (CLL) has evolved considerably. This advancement is due in part to increasing awareness of prognostic factors and molecular heterogeneity of the disease which has helped to identify distinct risk groups of CLL. In addition, novel treatment regimens have demonstrated much higher complete and overall response rates than previously seen with conventional CLL therapy. Indeed, as complete response rates exceed 50%, curative therapy for CLL is within reach. Ongoing clinical research may define the optimal treatment strategies and improve outcomes for patients with CLL.
authors.affiliation: University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Keating
authors.forename: Kanti R
authors.initials: KR
authors.lastname: Rai
authors.forename: William G
authors.initials: WG
authors.lastname: Wierda
mesh_terms: D035843:Biomedical Research / Q000639:trends; D002986:Clinical Trials as Topic / Q000639:trends; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D016896:Treatment Outcome