Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting.
Specialized M cells in the follicle-associated epithelium of intestinal Peyer's patches serve as portals for diverse particulates. Following antigen handover to dome lymphocytes, a protective mucosal antibody secretion ensues. One approach to oral vaccine delivery is to mimic the entry pathways of pathogens via M cells. The paucity of human tissue for in vitro investigation has hampered the discovery of M-cell pathogen receptors; however an in vitro human M like-cell culture model displays many expected phenotypic features. Comparative studies using microarrays reveal several novel M-cell surface receptors that could be used to potentially target orally delivered antigens.
Brayden
David J
DJ
Faculty of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. David.Brayden@ucd.ie
Jepson
Mark A
MA
Baird
Alan W
AW
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology* / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology; D014612:Vaccines
D000941:Antigens; D011956:Receptors, Cell Surface; D014612:Vaccines