Practical synthesis of Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate].
An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)(4), a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.
Tsutsui
Hideyuki
H
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Abe
Takumi
T
Nakamura
Seiichi
S
Anada
Masahiro
M
Hashimoto
Shunichi
S
D002384:Catalysis; D007930:Leucine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; C507508:dirhodium(II) tetrakis(N-phthaloyl-(S)-tert-leucinate); D012238:Rhodium; D007930:Leucine