title: [The concept of frailty--from phenomenology to therapeutic approaches].
abstract: Frailty--the weakness of many (oldest) old persons--induces a lot of human sorrow with functional disabilities as well as health-economic costs. Sarcopenia (loss of muscle mass) is also a form of frailty and a co-factor of two of the "geriatric Is"--immobility and instability. Pathophysiologically, both phenomena show signs of an inflammatory state. Physical activity and a healthy diet can partially reverse these health problems. Therefore, therapeutic strategies emerge to treat these frequent and clinically relevant phenomena.
authors.affiliation: Lehrstuhl Innere Medizin V (Geriatrie) der Friedrich-Alexander-Universität Erlangen-Nürnberg, Institut für Biomedizin des Alterns, Klinik II Klinikum Nürnberg, Prof.-Ernst-Nathan-Strasse 1, 90419, Nürnberg, Germany. sieber@klinikum-nuernberg.de
authors.forename: C C
authors.initials: CC
authors.lastname: Sieber
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004035:Diet Therapy; D005081:Exercise Therapy; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D009133:Muscular Atrophy / Q000175:diagnosis* / Q000517:prevention & control*; D009747:Nutritional Physiological Phenomena