title: The accuracy of left ventricular mass determined by real-time three-dimensional echocardiography in chronic animal and clinical studies: a comparison with postmortem examination and magnetic resonance imaging.
abstract: Real-time 3-dimensional echocardiography (RT3DE), 2-dimensional echocardiography (2DE), and M-mode echocardiography were performed in 28 sheep with cardiac pathologies and 27 patients with heart disease to demonstrate the superiority of RT3DE over M-mode and 2DE for the determination of left ventricular mass. Postmortem examination and magnetic resonance imaging were used as a reference standard for the animal and clinical studies, respectively. In the animal study, the highest concordance correlation (0.92) was obtained between the actual weight of left ventricular mass and that estimated by RT3DE (0.69 for 2DE and 0.77 for M-mode, P < .001). In the clinical study, RT3DE also provided the best concordance correlation with left ventricular mass determined by magnetic resonance imaging (0.91 for RT3DE, 0.83 for 2DE, and 0.38 for M-mode; P < .0001).
authors.affiliation: Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: Jian Xin
authors.initials: JX
authors.lastname: Qin
authors.forename: Michael
authors.initials: M
authors.lastname: Jones
authors.forename: Agnese
authors.initials: A
authors.lastname: Travaglini
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Song
authors.forename: Jianbo
authors.initials: J
authors.lastname: Li
authors.forename: Richard D
authors.initials: RD
authors.lastname: White
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsujino
authors.forename: Neil L
authors.initials: NL
authors.lastname: Greenberg
authors.forename: Arthur D
authors.initials: AD
authors.lastname: Zetts
authors.forename: Julio A
authors.initials: JA
authors.lastname: Panza
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shiota
mesh_terms: D000818:Animals; D002102:Cadaver; D002908:Chronic Disease; D003199:Computer Systems; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012756:Sheep; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*