title: Performance characterization of megavoltage computed tomography imaging on a helical tomotherapy unit.
abstract: Helical tomotherapy is an innovative means of delivering IGRT and IMRT using a device that combines features of a linear accelerator and a helical computed tomography (CT) scanner. The HI-ART II can generate CT images from the same megavoltage x-ray beam it uses for treatment. These megavoltage CT (MVCT) images offer verification of the patient position prior to and potentially during radiation therapy. Since the unit uses the actual treatment beam as the x-ray source for image acquisition, no surrogate telemetry systems are required to register image space to treatment space. The disadvantage to using the treatment beam for imaging, however, is that the physics of radiation interactions in the megavoltage energy range may force compromises between the dose delivered and the image quality in comparison to diagnostic CT scanners. The performance of the system is therefore characterized in terms of objective measures of noise, uniformity, contrast, and spatial resolution as a function of the dose delivered by the MVCT beam. The uniformity and spatial resolutions of MVCT images generated by the HI-ART II are comparable to that of diagnostic CT images. Furthermore, the MVCT scan contrast is linear with respect to the electron density of material imaged. MVCT images do not have the same performance characteristics as state-of-the art diagnostic CT scanners when one objectively examines noise and low-contrast resolution. These inferior results may be explained, at least partially, by the low doses delivered by our unit; the dose is 1.1 cGy in a 20 cm diameter cylindrical phantom. In spite of the poorer low-contrast resolution, these relatively low-dose MVCT scans provide sufficient contrast to delineate many soft-tissue structures. Hence, these images are useful not only for verifying the patient's position at the time of therapy, but they are also sufficient for delineating many anatomic structures. In conjunction with the ability to recalculate radiotherapy doses on these images, this enables dose guidance as well as image guidance of radiotherapy treatments.
authors.affiliation: Department of Radiation Oncology, M D Anderson Cancer Center Orlando, Orlando, Florida 32806, USA. smeeks@orhs.org
authors.forename: Sanford L
authors.initials: SL
authors.lastname: Meeks
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Harmon
authors.forename: Katja M
authors.initials: KM
authors.lastname: Langen
authors.forename: Twyla R
authors.initials: TR
authors.lastname: Willoughby
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Wagner
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Kupelian
mesh_terms: D003199:Computer Systems; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D011881:Radiotherapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D020266:Radiotherapy, Conformal / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration; D036542:Tomography, Spiral Computed / Q000295:instrumentation* / Q000379:methods