title: Sp transcription factor family and its role in cancer.
abstract: Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C(2)H(2)-type zinc fingers that are present at their C-terminal domains. Sp1-Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. Sp/KLF proteins are also potential targets for cancer chemotherapy.
authors.affiliation: Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 W. Holcombe Blvd., Houston, TX 77030-3303, USA. ssafe@cvm.tamu.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Safe
authors.forename: Maen
authors.initials: M
authors.lastname: Abdelrahim
mesh_terms: D002470:Cell Survival; D015870:Gene Expression; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D051703:Sp Transcription Factors / Q000145:classification / Q000235:genetics* / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D051703:Sp Transcription Factors; D042461:Vascular Endothelial Growth Factor A