[Research on the analgesic effect and mechanism of bornyl acetate in volatile oil from amomum villosum].
OBJECTIVE
To study the analgesic effect and mechanism of bornyl acetate, the main ingredient of Amomum Villosum Volatile oil.


METHODS
The analgesic effects were tested by pressing tail method. The I, and II phase pain were observed with the pain model caused by formalin test. Influence of naloxone antagonism test on analgesic effect of bornyl acetate.


RESULTS
Bornyl acetate produced obvious analgesic effects on pain models induced by pressing tail. Bornyl acetate had inhibitory effect on I and II phase pain in formalin inducing pain model animals. Analgesic effect induced by Bornyl acetate wasn't significantly reduced by naloxone.


CONCLUSIONS
Bornyl acetate shows analgesic effects. The analgesic site may locate in both central and peripheral nervous system. Its analgesic action way not be related to the opioid receptor.
Wu
Xiaosong
X
First Affiliated Hospital, Jinan University, Guangzhou.
Xiao
Fei
F
Zhang
Zhidong
Z
Li
Xiaoguang
X
Xu
Zhenxia
Z
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001892:Camphanes / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry*; D017288:Pain Threshold / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001892:Camphanes; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; C071528:bornyl acetate; D009270:Naloxone