title: [Children of HIV-positive mothers: 4 cases of contamination in 14 years of follow-up at the Rouen University Hospital Center].
abstract: The prevention of mother-to-child transmission is important in the control of HIV. Despite preventive measures, the objective of a zero transmission rate from mother to child has not yet been reached even in Northern countries.
  
  
  METHODS
  A retrospective study covering a 14-year period (January 1988 through December 2001) examined records of 80 children born to HIV-positive mothers at Rouen University Hospital Center. Four children were contaminated. We report several particularities of these four children, contaminated despite the preventive measures taken.
  
  
  CONCLUSIONS
  Prevention of mother-to-child transmission involves not only administration of antiretrovirals during pregnancy, but also better follow-up of pregnancy and delivery and more effective management of risk factors such as drug addiction and poverty. Multidisciplinary follow-up is needed for these children in view of our current lack of knowledge of the long-range side effects of these antiretrovirals.
authors.affiliation: Service de pédiatrie, Centre hospitalier universitaire Yalgado Ouédraogo, 01 BP 5488, Ouagadougou 01, Burkina Faso. yediarra@hotmail.com
authors.forename: Diarra
authors.initials: D
authors.lastname: Yé
authors.forename: Véronique
authors.initials: V
authors.lastname: Brossard
authors.forename: Anne
authors.initials: A
authors.lastname: Mercier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Marret
authors.forename: Brigitte
authors.initials: B
authors.lastname: Clavier
authors.forename: François
authors.initials: F
authors.lastname: Simon
authors.forename: Alphonse
authors.initials: A
authors.lastname: Sawadogo
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005602:France; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D012189:Retrospective Studies; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine