title: Asymmetric alkynylation of aldehydes catalyzed by an In(III)/BINOL complex.
abstract: Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the "bifunctional character" of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to >99% ee).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Takita
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yakura
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohshima
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; C406944:BINOL, naphthol; D009284:Naphthols; D009942:Organometallic Compounds; D007204:Indium