title: In-vitro antibacterial, antifungal and cytotoxic activities of some coumarins and their metal complexes.
abstract: A series of new antibacterial and antifungal coumarin-derived compounds and their transition metal complexes [cobalt (II), copper (II), nickel (II) and zinc (II)] have been synthesized, characterized and screened for their in vitro antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysenteriae, Bacillus cereus, Corynebacterium diphtheriae, Staphylococcus aureus and Streptococcus pyogenes bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida glaberata. The results of these studies show the metal complexes to be more antibacterial and antifungal as compared to the uncomplexed coumarins. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.
authors.affiliation: Department of Chemistry, University of Peshawar, Peshawar, Pakistan.
authors.forename: Saeed U
authors.initials: SU
authors.lastname: Rehman
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Farzana
authors.initials: F
authors.lastname: Gulnaz
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects*; D001419:Bacteria / Q000187:drug effects*; D001681:Biological Assay; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D028561:Transition Elements / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins; D028561:Transition Elements; C030123:coumarin