Helicobacter pylori infection increases cell kinetics in human gastric epithelial cells without adhering to proliferating cells.
We investigated the effect of H. pylori infection on cell proliferation of gastric mucosa using immunostaining for H. pylori or Ki67. H. pylori cells attached to surface mucous cells covering luminal surface and the upper part of gastric foveolae, and up-regulated the proliferative activity of gastric epithelial cells without adhering to the proliferating epithelial cells.
Hayama
Masayoshi
M
Department of Biomedical Laboratory Sciences, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Nagano, 390-8621, Japan. mahayama@hsp.md.shinshu-u.ac.jp
Kawakami
Yoshiyuki
Y
Kaneko
Yasunori
Y
Sano
Kenji
K
Ota
Hiroyoshi
H
D001422:Bacterial Adhesion; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans