Tumor cell formation by normal somatic cells fusing and cancer prevention prospects.
Malignant transformation might be ascribed to one of the rather widespread processes taking place in the organism daily and being genetically inherited in a normal somatic cell. In order that normal cells are transformed into malignant ones, they should undergo the following two stages: (1) initiation - the precancerous cell (first-stage synkarion) formation, and (2) promotion - the true tumor cell (second-stage synkaryon) formation. For promoting the tumor process, i.e. transformation into a true tumor synkaryon, first - stage synkaryon (precancerous cell) should go through the next stage/stages of development at the molecular and subcellular level. In a tumor synkaryon, in particular in its plasma membrane, most probably the antigenic mosaics of normal precursor cells is inherited and, therefore, such cells "escape" the effect of the immune forces of the body. In other words, antigenic determinants existing on the surface of normal initial (parent) precursor cells condition inaction of the so-called immune surveillance. The cancer prevention concept implies synchronous conversion of a tumor cell into the stage of nonviable polykaryocytes. In addition, for preventing this fatal disease the inhibition of the process of approaching and further adhesion of normal somatic cells would suffice. The expected outcome would be the creation in the body of the conditions when somatic cells are incapable of close contacts with each other (not injurious for organism). This will completely exclude the fusion of cells and then nuclei and reduce thus to a minimum the possibility of cancer cell development.
Gogichadze
G K
GK
Georgian State Medical Academy, 29.1 Chavchavadze Avenue, Tbilisi 0179, Georgia, USA. gogi_gogichadze@yahoo.com
Misabishvili
E V
EV
Gogichadze
T G
TG
D002459:Cell Fusion; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology* / Q000517:prevention & control*