title: Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease.
abstract: Among 27 preclinical carriers of the Huntington disease mutation (PMC), the authors found normal striatal values for MRI volumetry in 88% and for fluorodesoxyglucose PET metabolic index in 67%. Raclopride PET binding potential (RAC-BP) was decreased in 50% and correlated with increases in the product of age and CAG repeat length (p < 0.0005). Dopamine D2 receptor availability measured by RAC-BP seems the most sensitive indicator of early neuronal impairment in PMC.
authors.affiliation: Department of Neurology, Groningen University Medical Center, Groningen, The Netherlands.
authors.forename: J C H
authors.initials: JC
authors.lastname: van Oostrom
authors.forename: R P
authors.initials: RP
authors.lastname: Maguire
authors.forename: C C
authors.initials: CC
authors.lastname: Verschuuren-Bemelmans
authors.forename: L
authors.initials: L
authors.lastname: Veenma-van der Duin
authors.forename: J
authors.initials: J
authors.lastname: Pruim
authors.forename: R A C
authors.initials: RA
authors.lastname: Roos
authors.forename: K L
authors.initials: KL
authors.lastname: Leenders
mesh_terms: D000328:Adult; D001667:Binding, Competitive / Q000502:physiology; D015415:Biomarkers; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D004252:DNA Mutational Analysis; D018450:Disease Progression; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009410:Nerve Degeneration / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D020891:Raclopride / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics
chemical_list: D015415:Biomarkers; D018492:Dopamine Antagonists; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D017448:Receptors, Dopamine D2; D019788:Fluorodeoxyglucose F18; D020891:Raclopride; D005947:Glucose; D004298:Dopamine