Effective long-range attraction between protein molecules in solutions studied by small angle neutron scattering.
Small angle neutron scattering intensity distributions taken from cytochrome C and lysozyme protein solutions show a rising intensity at a very small wave vector Q, which can be interpreted in terms of the presence of a weak long-range attraction between protein molecules. This interaction has a range several times that of the diameter of the protein molecule, much greater than the range of the screened electrostatic repulsion. We show evidence that this long-range attraction is closely related to the type of anion present and ion concentration in the solution.
Liu
Yun
Y
Department of Nuclear Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fratini
Emiliano
E
Baglioni
Piero
P
Chen
Wei-Ren
WR
Chen
Sow-Hsin
SH
D000818:Animals; D002645:Chickens; D045304:Cytochromes c / Q000737:chemistry*; D004527:Egg Proteins / Q000737:chemistry; D006736:Horses; D007700:Kinetics; D009113:Muramidase / Q000737:chemistry*; D033363:Neutron Diffraction / Q000379:methods*; D012996:Solutions
D004527:Egg Proteins; D012996:Solutions; D045304:Cytochromes c; D009113:Muramidase