title: Aneuploidy involving chromosome 1 in failed-fertilized human oocytes is unrelated to maternal age.
abstract: OBJECTIVE
  To study whether maternal meiotic errors in failed-fertilized oocytes involving chromosome 1 occur at frequencies similar to those involving other autosomes, and whether their frequency is affected by maternal age.
  
  
  METHODS
  Using fluorescence in situ hybridization (FISH), frequencies of aneusomy and chromatid pre-division involving chromosomes 1, 16, 18, and 21 were determined for 273 failed-fertilized oocytes.
  
  
  RESULTS
  The aneuploidy rate for chromosome 1 was 15.8%, and was neither age-dependent nor significantly different from that for chromosomes 16, 18 or 21. Only chromosome 16 exhibited an age-dependent increase in aneusomy rates. The frequency of chromatid pre-division was lower for chromosome 1 than for chromosome 18 (11.9% vs. 25.4%; p = 0.01), but not different from that for chromosomes 16 or 21.
  
  
  CONCLUSIONS
  Aneuploidy involving chromosome 1 in failed-fertilized oocytes is unrelated to maternal age and occurs at a frequency similar to that for chromosomes 16, 18, and 21.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Francisco, USA. jlfung@itsa.ucsf.edu
authors.forename: Jingly Fung
authors.initials: JF
authors.lastname: Weier
authors.forename: Heinz-Ulrich G
authors.initials: HU
authors.lastname: Weier
authors.forename: Aida
authors.initials: A
authors.lastname: Nureddin
authors.forename: Roger A
authors.initials: RA
authors.lastname: Pedersen
authors.forename: Catherine
authors.initials: C
authors.lastname: Racowsky
mesh_terms: D000782:Aneuploidy; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008423:Maternal Age; D008540:Meiosis; D008677:Metaphase; D009865:Oocytes; D011247:Pregnancy