[Clinical significance of antibiotic prophylaxis for transrectal prostate biopsy].
OBJECTIVE
To evaluate the efficacy and safety of single-dose oral antibiotic prophylaxis in the


METHODS
Between prevention of post-procedure infections in patients undergoing transrectal prostate biopsy. September 1998 and March 2001, a total of 192 patients who had an abnormal digital rectal examination and/or prostate specific antigen 4 ng/ml or greater underwent transrectal ultrasound guided systematic 13 cores prostate biopsy. The patients were randomly divided into three groups. Group A (62) received a placebo (Vit C) tablet twice a day for 3 days, group B (64) a single dose of ciprofloxacin (0.5 g) and metronidazole (0.4 g), and group C (66) the same combination twice a day for 3 days. Urine cultures were obtained 48 h after the biopsy and blood cultures when patients who developed fever.


RESULTS
Noninfective complications included were rectal bleeding, haematuria and pain. Infective complications included urinary tract infection and fever. There was no significant difference among the three groups in noninfective complications but the incidence of infective complications in group A was significantly higher than in groups B and C (P < 0.01). There was no significant difference among group B and C in infective complications (P > 0.05).


CONCLUSIONS
Our study shows single-dose oral antibiotic prophylaxis is effective and safe to prevent infectious complications follow transrectal prostate biopsy.
Yang
L
L
Department of Urology, First Municipal Hospital of Guangzhou, Guangzhou 510180, China.
Hu
J
J
Wei
H
H
Wang
L
L
Zhong
H
H
D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis; D001707:Biopsy, Needle / Q000009:adverse effects* / Q000379:methods; D002939:Ciprofloxacin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage; D011446:Prospective Studies; D011469:Prostatic Diseases / Q000473:pathology*; D018084:Ultrasonography, Interventional; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control*
D008795:Metronidazole; D002939:Ciprofloxacin; D015242:Ofloxacin