title: Octogenarians undergoing coronary artery bypass graft surgery: resource utilization, postoperative mortality, and morbidity.
abstract: OBJECTIVE
  The purpose of the present study was to examine resource utilization in octogenarians undergoing coronary artery bypass grafting (CABG) and compare it with usage in their younger cohorts at a tertiary care heart center. The resources examined were time to extubation, packed red blood cell transfusions, intensive care unit (ICU) length of stay (LOS), and preoperative and postoperative LOS. The study also examined differences in postoperative morbidity and mortality.
  
  
  METHODS
  Retrospective hospital follow-up study of consecutive patients undergoing CABG using a prospectively designed database.
  
  
  METHODS
  University teaching tertiary care referral center for cardiac surgery.
  
  
  METHODS
  Seventeen hundred forty-six male and female patients undergoing CABG surgery, including 155 octogenarians and 1591 patients younger than 80 years.
  
  
  METHODS
  None.
  
  
  RESULTS
  Demographic, mortality, morbidity, and resource utilization data were collected from the records of patients undergoing CABG at the authors' institution over 3 years. There were 1746 patients: 155 octogenarians and 1591 nonoctogenarians. Octogenarians had a significantly higher incidence of preoperative stroke, peripheral vascular disease, chronic obstructive lung disease, congestive heart failure, and left main disease. They weighed significantly less, and had lower preoperative and postoperative hematocrit. There was a significantly higher percentage of women in the octogenarian group. Mean time from the end of surgery to endotracheal extubation was 9.3 hours for octogenarians and 6.3 hours for their younger cohorts (p < 0.001). Blood transfusion was required in 88.4% of octogenarians compared with 58.6% of nonoctogenarians (p < 0.001). Mean ICU LOS was 1.9 days for octogenarians and 1.4 days for nonoctogenarians (p < 0.001). Mean postoperative LOS was 8.7 days for octogenarians and 5.8 days for nonoctogenarians (p < 0.001). Clinical and demographic variables were correlated with age 80 years or older. Multivariate linear and logistic regression models were constructed to show the combined effects of age and comorbid conditions on outcomes. Octogenarians had a significantly higher incidence of postoperative renal failure and neurologic complications. The 30-day mortality rate was 9.0% for the octogenarian group v 1.2% for the younger group (p < 0.001). Age 80 years or older was significantly associated with outcome, and was an independent predictor of increased resource utilization and postoperative mortality and morbidity.
  
  
  CONCLUSIONS
  The results demonstrated that octogenarians undergoing CABG required increased resource utilization and had significantly higher morbidity, with increased incidence of postoperative renal failure, neurologic complications, and 30- day mortality. Age 80 years or older was an independent predictor of increased resource utilization, postoperative morbidity, and mortality.
authors.affiliation: Department of Anesthesiology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8480, USA. Bharathi.Scott@stonybrook.edu
authors.forename: Bharathi H
authors.initials: BH
authors.lastname: Scott
authors.forename: Frank C
authors.initials: FC
authors.lastname: Seifert
authors.forename: Roger
authors.initials: R
authors.lastname: Grimson
authors.forename: Peter S A
authors.initials: PS
authors.lastname: Glass
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006295:Health Resources / Q000706:statistics & numerical data; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008323:Mammary Arteries / Q000601:surgery; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome