title: Nicotinamide: a double edged sword.
abstract: Enrichment of diet with Nicotinamide in the West was introduced in the 1940s to prevent the dietary deficiency disorder Pellagra. Pellagra was caused by a particular form of poor vegetarian diet leading to Nicotinamide and Tryptophan deficiency. Arguably Pellagra would have disappeared if dietary measures suggested at the time had been implemented before Nicotinamide was even discovered. Diets may sometimes now be too high in selected pyridines and inadvertently we have exchanged one neurodegenerative disease for another. Parkinson's disease triggered in contrast to Pellagra by a particular form of rich omnivorous diet. Moderation of Nicotinamide intake would be easy to begin with compared with other dietary manipulations as there is no behavior change necessary for individuals. A substantial amount of Nicotinamide can be removed when and where there is too much that has been introduced artificially and inserted where there is too little because meat is unaffordable.
authors.affiliation: Division of Neurosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. adrian.williams@uhb.nhs.uk
authors.forename: Adrian
authors.initials: A
authors.lastname: Williams
authors.forename: David
authors.initials: D
authors.lastname: Ramsden
mesh_terms: D006801:Humans; D020267:MPTP Poisoning / Q000209:etiology* / Q000517:prevention & control*; D009536:Niacinamide / Q000009:adverse effects*; D010383:Pellagra / Q000188:drug therapy* / Q000517:prevention & control; D014803:Vitamin B Complex / Q000009:adverse effects*
chemical_list: D014803:Vitamin B Complex; D009536:Niacinamide