Regional specialization in pyramidal cell structure in the limbic cortex of the vervet monkey (Cercopithecus pygerythrus): an intracellular injection study of the anterior and posterior cingulate gyrus.
The pyramidal cell phenotype varies quite dramatically in structure among different cortical areas in the primate brain. Comparative studies in visual cortex, in particular, but also in sensorimotor and prefrontal cortex, reveal systematic trends for pyramidal cell specialization in functionally related cortical areas. Moreover, there are systematic differences in the extent of these trends between different primate species. Recently we demonstrated differences in pyramidal cell structure in the cingulate cortex of the macaque monkey; however, in the absence of other comparative data it remains unknown as to whether the neuronal phenotype differs in cingulate cortex between species. Here we extend the basis for comparison by studying the structure of the basal dendritic trees of layer III pyramidal cells in the posterior and anterior cingulate gyrus of the vervet monkey (Brodmann's areas 23 and 24, respectively). Cells were injected with Lucifer Yellow in flat-mounted cortical slices, and processed for a light-stable DAB reaction product. Size, branching pattern, and spine density of basal dendritic arbors were determined, and somal areas measured. As in the macaque monkey, we found that pyramidal cells in anterior cingulate gyrus (area 24) were more branched and more spinous than those in posterior cingulate gyrus (area 23). In addition, the extent of the difference in pyramidal cell structure between these two cortical regions was less in the vervet monkey than in the macaque monkey.
Elston
Guy N
GN
Vision, Touch and Hearing Research Centre, School of Biomedical Sciences and Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia. G.Elston@vthrc.uq.edu.au
Benavides-Piccione
Ruth
R
Elston
Alejandra
A
Manger
Paul
P
Defelipe
Javier
J
D000818:Animals; D002452:Cell Count; D048429:Cell Size; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology; D002522:Chlorocebus aethiops; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D007150:Immunohistochemistry; D008032:Limbic System / Q000166:cytology / Q000502:physiology*; D008297:Male; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure