Natriuretic peptides in the perioperative management of cardiac surgery patients.
Both heart failure (HF) and cardiac surgery with cardiopulmonary bypass result in a release of neurohormones, with a variety of physiologic effects. Administration of exogenous B-type natriuretic peptide (BNP) has beneficial hemodynamic effects and reduces the level of several neurohormones in HF patients. BNP is currently being investigated in the perioperative management of cardiac surgery patients and may be especially beneficial for patients with ventricular dysfunction, pulmonary hypertension, or renal dysfunction. Using a neurohormonal approach to supportive therapy may enhance future strategies for patients undergoing cardiac surgery, especially those at greatest risk for complications.
Moazami
Nader
N
Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO, USA.
Oz
Mehmet C
MC
D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000601:surgery*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000627:therapeutic use*; D018377:Neurotransmitter Agents / Q000097:blood; D019990:Perioperative Care; D011184:Postoperative Period
D018377:Neurotransmitter Agents; D020097:Natriuretic Peptide, Brain