[Lymphatic vessels and cancer].
Survival and development of tumors depends on nutritional and respiratory biological events and exchanges ensured by blood and lymph. Tumor proliferation is associated with an increase in the vascular networks either near the tumor or intra-tumorally. Tumor tissues are able to increase their provisionment according to their needs while directing and optimizing the development of peri-tumoral vessels. The production of growth factors stimulating neo-formation of lymphatic vessels by cancer cells constitutes one of the adaptations responsible for metastatic propagation. During tumor development the lymphatic system is considered in many cases of cancer as the primary means of metastasis dissemination. The study of the lymphatic system setting and ways to block it are important points to consider in oncology.
Leclers
Dany
D
Médecine moléculaire humaine EA 3839, Faculté de Médecine, 2, Limoges, France. dany.leclers@unilim.fr
Durand
Karine
K
Dutour
Aurélie
A
Barrière
Guislaine
G
Monteil
Jacques
J
Rigaud
Michel
M
Sturtz
Franck
F
D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D006801:Humans; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels / Q000276:immunology / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009369:Neoplasms / Q000503:physiopathology*