Organic solvents and the dopaminergic system.
Organic solvents pose a considerable health risk for humans. It is due to their ability to cross biological barriers and indisputable toxicity on the one hand, and the wealth of applications and large production and consumption volumes on the other. The primary target of the toxic action of organic solvents is the nervous system. In this paper, some literature data showing that dopaminergic neurons and their projections are particularly susceptible to the toxic solvent action are presented.
Gralewicz
Sławomir
S
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lódź, Poland. gralslaw@imp.lodz.pl
Dyzma
Michał
M
D000818:Animals; D006801:Humans; D009474:Neurons / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000633:toxicity; D016273:Occupational Exposure / Q000009:adverse effects; D009930:Organic Chemicals / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology; D011388:Prolactin / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects*; D012903:Smell / Q000187:drug effects; D012997:Solvents / Q000633:toxicity*; D014785:Vision, Ocular / Q000187:drug effects
D018377:Neurotransmitter Agents; D009930:Organic Chemicals; D011954:Receptors, Dopamine; D012997:Solvents; D011388:Prolactin