A general and versatile molecular design for host molecules working in water: a duplex-based potassium sensor consisting of three functional regions.
A general and versatile molecular design for host molecules was proposed based on the structural motif of antibodies. A water-soluble potassium sensor was developed by this molecular design, which consists of three functional regions, benzo-15-crown-5 ether, DNA, and pyrene as guest-binding, dimerising, and signaling sites, respectively. The molecular sensor emitted the monomer fluorescence of the pyrene fluorophore predominantly when existing as a random structure, while it formed a duplex upon recognition of K+ to bring about monomer-excimer emission switching.
Fujimoto
Kazuhisa
K
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan. fujimoto@ms.toyama-mpu.ac.jp
Muto
Yu
Y
Inouye
Masahiko
M
D043844:Crown Ethers / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D017736:Ion-Selective Electrodes; D015394:Molecular Structure; D011188:Potassium / Q000032:analysis*; D011721:Pyrenes / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013696:Temperature; D014867:Water / Q000737:chemistry
D043844:Crown Ethers; D011721:Pyrenes; D014867:Water; D004247:DNA; D011188:Potassium