Neurogenic inflammation in acute pancreatitis.
Acute pancreatitis is a clinical condition whose incidence has increased over the past few years. The exact mechanism of its development is not yet clear. Substance P, the proinflammatory neuropeptide, has a role in the initiation of neurogenic inflammation. Substance P and its receptor neurokinin-1 receptor (NK-1R) are involved in the development of local as well as systemic inflammation in acute pancreatitis. This editorial focuses on the role of substance P and its receptors in the development of acute pancreatitis.
Hegde
Akhil
A
Bhatia
Madhav
M
D000208:Acute Disease; D006801:Humans; D020078:Neurogenic Inflammation / Q000209:etiology / Q000503:physiopathology*; D010195:Pancreatitis / Q000209:etiology / Q000503:physiopathology*; D018040:Receptors, Neurokinin-1 / Q000502:physiology*; D013373:Substance P / Q000502:physiology*
D018040:Receptors, Neurokinin-1; D013373:Substance P