title: Red wine acutely induces favorable effects on wave reflections and central pressures in coronary artery disease patients.
abstract: BACKGROUND
  To investigate red wine's acute effects on aortic pressures and arterial stiffness in patients with coronary artery disease (CAD).
  
  
  METHODS
  Fifteen patients with CAD were recruited in a double-blind, cross-over study, which was comprised of 2 study days. Each volunteer consumed either 250 mL of regular or 250 mL of dealcoholized red wine. Wave reflections, expressed as augmentation index (AIx), as well as central and peripheral blood pressures (BP) were assessed at fast and 30, 60, and 90 min postprandially.
  
  
  RESULTS
  Both regular and dealcoholized red wine caused a significant decrease in AIx by 10.5% +/- 1.4% (P = .001) and 6.1% +/- 1.4% (P = .011), respectively, whereas no significant change was induced in mean BP and timing of wave reflections expressing pulse wave velocity. Peripheral systolic BPs remained unaltered in both beverages, whereas a significant decrease in peripheral and central diastolic BPs was observed after the dealcoholized red wine consumption (P = .03 and P = .035, respectively). Central systolic BP was decreased after the consumption of regular (-7.4 +/- 2.4 mm Hg, P = .05) and dealcoholized red wine (-5.4 +/- 2.7 mm Hg, P = .019).
  
  
  CONCLUSIONS
  Both types of red wine provoked favorable acute effects on wave reflections and central systolic pressures, whereas no such effect was evident at the brachial artery. Therefore, these findings could be attributed mainly to red wine antioxidant substances, rendering it a possible means of at least acute attenuation of increased wave reflections, arterial stiffness, and central pressures in patients with coronary artery disease.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Kalliopi N
authors.initials: KN
authors.lastname: Karatzi
authors.forename: Christos M
authors.initials: CM
authors.lastname: Papamichael
authors.forename: Emmanouil N
authors.initials: EN
authors.lastname: Karatzis
authors.forename: Theodoros G
authors.initials: TG
authors.lastname: Papaioannou
authors.forename: Konstantinos A
authors.initials: KA
authors.lastname: Aznaouridis
authors.forename: Paraskevi P
authors.initials: PP
authors.lastname: Katsichti
authors.forename: Kimon S
authors.initials: KS
authors.lastname: Stamatelopoulos
authors.forename: Antonis
authors.initials: A
authors.lastname: Zampelas
authors.forename: John P
authors.initials: JP
authors.lastname: Lekakis
authors.forename: Myron E
authors.initials: ME
authors.lastname: Mavrikakis
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D003324:Coronary Artery Disease / Q000473:pathology / Q000503:physiopathology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D000431:Ethanol / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D011673:Pulsatile Flow / Q000502:physiology; D017534:Radial Artery / Q000503:physiopathology; D013997:Time Factors; D014920:Wine
chemical_list: D000975:Antioxidants; D000431:Ethanol