Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.
The susceptibility of typical class D beta-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM beta-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.
Adediran
S A
SA
Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
Nukaga
Michiyoshi
M
Baurin
Stéphane
S
Frère
J-M
JM
Pratt
R F
RF
D006839:Hydrocarbons, Acyclic / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D010710:Phosphates / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000145:classification*
D006839:Hydrocarbons, Acyclic; D063065:Organophosphonates; D010710:Phosphates; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases