Calcinosis cutis with siliconomas complicated by hypercalcemia.
OBJECTIVE
To report a case of extensive calcinosis cutis presumably caused by silicone injections, which was complicated by hypercalcemia.


METHODS
A long-standing case of calcinosis cutis with subsequent development of hypercalcemia is presented, and possible mechanisms for the underlying metabolic dysfunction are discussed.


RESULTS
A 78-year-old woman presented with severe hypercalcemia and was found to have extensive subcutaneous calcifications on the anterior chest wall and abdomen, likely related to previous silicone injections. The hypercalcemia was treated with intravenously administered pamidronate and aggressive rehydration. Resection of the extensive long-standing calcific deposits was not a viable option. The hypercalcemia resolved with treatment, but the patient died of urinary tract sepsis.


CONCLUSIONS
Extensive calcinosis cutis can result in hypercalcemia, possibly attributable to granulomatous reaction and vitamin D excess.
Loke
Seng Cheong
SC
Department of Endocrinology, Tan Tock Seng Hospital, Singapore.
Leow
Melvin Khee-Shing
MK
D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002114:Calcinosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002118:Calcium / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D015745:Granuloma, Foreign-Body / Q000150:complications* / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007279:Injections, Subcutaneous; D000077268:Pamidronate; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014807:Vitamin D / Q000502:physiology
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D012828:Silicones; D014807:Vitamin D; D000077268:Pamidronate; D002118:Calcium