Prostate cancer risk among men with diabetes mellitus (Spain).
OBJECTIVE
Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.


METHODS
Population based case-control study nested in a cohort.


RESULTS
We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.


CONCLUSIONS
Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
González-Pérez
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Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain. agonzalez@ceife.es
García Rodríguez
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D000368:Aged; D016022:Case-Control Studies; D019992:Databases as Topic; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005194:Family Practice; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D012306:Risk; D018570:Risk Assessment; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology
D007004:Hypoglycemic Agents