title: Metabolic pathway of magnetized fluid-induced relaxation effects on heart muscle.
abstract: The effect of magnetized physiological solution (MPS) on isolated, perfused snail heart muscle contractility, (45)Ca uptake and intracellular level of cAMP, and cGMP was studied. The existence of the relaxing effect of MPS on heart muscle at room temperature (22 degrees C) and its absence in cold medium (4 degrees C) was shown. The MPS had a depressing effect on (45)Ca uptake by muscles and intracellular cAMP content and an elevating effect on intracellular cGMP level. It is suggested that the relaxing effect of MPS on heart muscle is due to the decrease of intracellular Ca ions as the result of activation of cGMP-dependent Ca efflux. The MPS induced decrease of intracellular cAMP content can be considered as a consequence of intracellular Ca loss, leading to the Na + K-ATPase reactivation, and causing the decrease of the intracellular level of ATP, serving as a substrate and positive modulator of cyclase activity.
authors.affiliation: UNESCO Chair-Life Sciences International Postgraduate Educational Center, Yerevan, Armenia.
authors.forename: Gayane
authors.initials: G
authors.lastname: Ayrapetyan
authors.forename: Alexander
authors.initials: A
authors.lastname: Papanyan
authors.forename: Hovik
authors.initials: H
authors.lastname: Hayrapetyan
authors.forename: Sinerik
authors.initials: S
authors.lastname: Ayrapetyan
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006372:Helix, Snails; D066298:In Vitro Techniques; D008280:Magnetics; D009126:Muscle Relaxation; D009206:Myocardium / Q000378:metabolism*
chemical_list: D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium