Transcription factors and drug resistance.
Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance. Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors. Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin.
Kohno
Kimitoshi
K
Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka 807-8555, Japan. k-kohno@med.uoeh-u.ac.jp
Uchiumi
Takeshi
T
Niina
Ichiro
I
Wakasugi
Tetsuro
T
Igarashi
Tomonori
T
Momii
Yasutomo
Y
Yoshida
Takeshi
T
Matsuo
Ken-Ichi
K
Miyamoto
Naoya
N
Izumi
Hiroto
H
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D004249:DNA Damage / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology
D000970:Antineoplastic Agents; D014157:Transcription Factors; D002945:Cisplatin