title: Anterior mediastinal immature teratoma with precocious puberty in a child with Klinefelter syndrome.
abstract: Klinefelter syndrome occurs in approximately 1 in 1000 males. A 4-year-old boy presented with precocious puberty and an anterior mediastinal mass. Serum alpha-fetoprotein and human chorionic gonadotropin levels were mildly increased. Computed tomography revealed a germ cell tumor (GCT) of the mediastinum. Complete resection of the tumor was performed. Histologic analysis revealed an immature teratoma. Males with Klinefelter syndrome develop GCTs at a rate 50 times higher than unaffected males. This case report calls attention to the need to rule out Klinefelter syndrome in boys who present with precocious puberty and a mediastinal GCT.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Pen-Hua
authors.initials: PH
authors.lastname: Su
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Luh
authors.forename: Da-Mien
authors.initials: DM
authors.lastname: Yieh
authors.forename: Jia-Yuh
authors.initials: JY
authors.lastname: Chen
authors.forename: Suh-Jen
authors.initials: SJ
authors.lastname: Chen
authors.forename: Huei-Mei
authors.initials: HM
authors.lastname: Hung
authors.forename: Pei-Fen
authors.initials: PF
authors.lastname: Liao
mesh_terms: D002675:Child, Preschool; D018237:Germinoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D011629:Puberty, Precocious / Q000209:etiology*; D011859:Radiography