Free modeling with Rosetta in CASP6.
We describe Rosetta predictions in the Sixth Community-Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP), focusing on the free modeling category. Methods developed since CASP5 are described, and their application to selected targets is discussed. Highlights include improved performance on larger proteins (100-200 residues) and the prediction of a 70-residue alpha-beta protein to near-atomic resolution.
Bradley
Philip
P
University of Washington, Seattle, Washington.
Malmström
Lars
L
University of Washington, Seattle, Washington.
Qian
Bin
B
University of Washington, Seattle, Washington.
Schonbrun
Jack
J
University of Washington, Seattle, Washington.
Chivian
Dylan
D
University of Washington, Seattle, Washington.
Kim
David E
DE
University of Washington, Seattle, Washington.
Meiler
Jens
J
Vanderbilt University, Nashville, Tennesee.
Misura
Kira M S
KMS
University of Washington, Seattle, Washington.
Baker
David
D
University of Washington, Seattle, Washington.
D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D030562:Databases, Protein; D008958:Models, Molecular; D008962:Models, Theoretical; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D016415:Sequence Alignment; D012984:Software