title: Pd-catalyzed asymmetric allylic amination using aspartic acid derived P-chirogenic diaminophosphine oxides: DIAPHOXs.
abstract: [reaction: see text] A Pd-catalyzed asymmetric allylic amination using aspartic acid derived P-chirogenic diaminophosphine oxides (DIAPHOXs) is described. Asymmetric allylic amination of both linear and cyclic substrates proceeded at room temperature to give the chiral allylic amines in 72-99% ee.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Nemoto
authors.forename: Takamasa
authors.initials: T
authors.lastname: Masuda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hamada
mesh_terms: D000586:Amination; D001224:Aspartic Acid / Q000737:chemistry*; D001596:Benzylamines / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D010105:Oxygenases / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D001596:Benzylamines; D002254:Carbonates; D010087:Oxides; D010720:Phosphines; D012997:Solvents; D001224:Aspartic Acid; D010165:Palladium; C030796:benzylamine; D010105:Oxygenases; C072883:alkene monooxygenase