title: Serological and molecular evidence that human herpesvirus 8 is endemic among Amerindians in French Guiana.
abstract: We evaluated the presence of human herpesvirus 8 (HHV-8) infection among groups of Amerindians in French Guiana. The overall prevalence of antibodies against lytic HHV-8 antigens was 23.0% (180/781), increasing from 18.4% in children <6 years old to approximately 30% in older persons (>45 years). Seroprevalence was higher in Amerindians living in remote localities than it was in those living in the coastal region. Analysis of a 725-base pair fragment of the K1 gene amplified from DNA from a Wayampi Amerindian showed that the virus belonged to molecular subtype E, which has hitherto been found in only a few Amerindians in Brazil and Ecuador.
authors.affiliation: Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, Cayenne, French Guiana. mkazanji@pasteur.fr
authors.forename: Mirdad
authors.initials: M
authors.lastname: Kazanji
authors.forename: Philippe
authors.initials: P
authors.lastname: Dussart
authors.forename: Renan
authors.initials: R
authors.lastname: Duprez
authors.forename: Patricia
authors.initials: P
authors.lastname: Tortevoye
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Pouliquen
authors.forename: Julie
authors.initials: J
authors.lastname: Vandekerkhove
authors.forename: Pierre
authors.initials: P
authors.lastname: Couppié
authors.forename: Jacques
authors.initials: J
authors.lastname: Morvan
authors.forename: Antoine
authors.initials: A
authors.lastname: Talarmin
authors.forename: Antoine
authors.initials: A
authors.lastname: Gessain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D050976:Basic-Leucine Zipper Transcription Factors / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics; D019353:Endemic Diseases; D005616:French Guiana / Q000453:epidemiology; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000097:blood / Q000453:epidemiology* / Q000208:ethnology* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007198:Indians, North American; D007223:Infant; D008875:Middle Aged; D015995:Prevalence; D012097:Repressor Proteins / Q000276:immunology; D012424:Rural Population; D016036:Seroepidemiologic Studies; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D050976:Basic-Leucine Zipper Transcription Factors; D004279:DNA, Viral; C111600:K1 protein, Human herpesvirus 8; C118265:K8 protein, Human herpesvirus 8; D012097:Repressor Proteins; D014764:Viral Proteins