Physicochemical characterization of rutaecarpine-loaded microemulsion system.
To develop an o/w microemulsion system containing poorly water-soluble rutaecarpine, the solubility of rutaecarpine in water, ethanol, various oils, and surfactants were investigated. Among the surfactants and oils tested, Tween 20/PEG 400 and castor oil were chosen as the surfactant system and oil phase of the microemulsion, as rutaecarpine was most soluble in them, respectively. Pseudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, and cosurfactant for microemulsion formation, and the stability test of rutaecarpine delivered by microemulsion formation was then evaluated. Pseudoternary phase diagrams show that the areas of microemulsion appeared at those with 0-20% Smix (PEG 400/Tween80 = 60/40), 64-81% water, and 10-20% oil. The rutaecarpine (300 microg/g)-loaded microemulsion composed of 10.8% PEG 400, 7.2% Tween 80, 20% caster oil, and 72% water was physically and chemically stable for at least 6 months. Thus, the microemulsion system composed of castor oil, PEG 400, Tween 80, and water could be a stable dosage form for rutaecarpine.
Choi
Han-Gon
HG
College of Pharmacy, Yeungnam University, Gyongsan, South Korea.
Park
Byung-Joo
BJ
Kim
Jong Oh
JO
Park
Young-Joon
YJ
Kim
Jin-Ki
JK
Yoo
Bong-Kyu
BK
Rhee
Jong-Dal
JD
Jahng
Yurngdong
Y
Yong
Chul Soon
CS
D000470:Alkaloids / Q000737:chemistry*; D004655:Emulsions; D000431:Ethanol / Q000737:chemistry; D026121:Indole Alkaloids; D009821:Oils / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry*; D011799:Quinazolines; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014665:Vasodilator Agents / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D052999:Quinazolinones
D000470:Alkaloids; D004655:Emulsions; D000431:Ethanol; D026121:Indole Alkaloids; D009821:Oils; D010975:Platelet Aggregation Inhibitors; D011092:Polyethylene Glycols; D011136:Polysorbates; D011799:Quinazolines; D013501:Surface-Active Agents; D014665:Vasodilator Agents; D014867:Water; C028632:rutecarpine; D052999:Quinazolinones