Prognostic risk factors in patients with interstitial lung disease referred for lung transplantation.
The aim of the study was to identify prognostic factors that would differentiate patients with interstitial lung disease between those with and without a chance to survive until lung transplantation. A retrospective study was performed in patients with interstitial lung disease referred for lung transplantation between September 1999 and April 2005. The analysis included the demographic data, the time from referral to transplantation, the functional tests (FVC, FEV1, FEV1%VC, the PaO(2) at rest and after oxygen supplementation via a nasal catheter), the count of NYHA functional classes, the left ventricular ejection fraction (EF), the distance covered during a 6-min walk test, and the pathogens in the respiratory tract. The patients were divided into two groups: Group 1 - lung transplant candidates who survived until the successful procedure and Group 2 - lung transplant candidates who died while on the waiting list. There were statistical differences between the two groups in PaO2 after supplementation (P=0.005), EF (P=0.002), and the 6-min walk distance (P=0.001). It appears that simple functional tests of the cardiorespiratory system may define survival of patients with interstitial lung disease waiting for lung transplantation.
Jastrzebski
D
D
Department of Lung Diseases and Tuberculosis, Silesian School of Medicine, Zabrze, Poland. ftpulmza@slam.katowice.pl
Kozielski
J
J
Nowak
J
J
Zielińska-Leś
I
I
Ziora
D
D
Szulik
B
B
Wojarski
J
J
Zakliczyński
M
M
Zembala
M
M
D000328:Adult; D001784:Blood Gas Analysis; D005260:Female; D006304:Health Status; D006801:Humans; D053208:Kaplan-Meier Estimate; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011379:Prognosis; D012017:Referral and Consultation; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013147:Spirometry; D013318:Stroke Volume; D016277:Ventricular Function, Left; D014850:Waiting Lists; D016138:Walking
D010100:Oxygen