title: Monogenic causes of stroke.
abstract: Monogenic disorders account for only a minority of strokes. Yet, they have been particularly helpful in exploring basic disease mechanisms. This article summarizes some recent data on monogenic stroke while focusing on two conditions: CADASIL, as a genetic variant of ischemic small vessel disease, and familial forms of cerebral amyloid angiopathy, which share many properties with sporadic disease.
authors.affiliation: Neurologische Klinik, Klinikum Grosshadern, Munich, Germany. mdichgans@nefo.med.uni-muenchen.de
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications; D046589:CADASIL / Q000150:complications / Q000235:genetics; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000235:genetics; D003704:Dementia / Q000150:complications; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D020521:Stroke / Q000150:complications / Q000235:genetics*