title: [Anabolic therapy of osteoporosis].
abstract: Osteoporosis is one of the most important problems in developed societies. Unfortunately, all drugs available nowadays on the market exhibit antiresorptive action bringing only moderate benefits to patients suffering from this disease. For the last few years, the number of studies on the suggested use of anabolic therapy in the treatment of osteoporosis has been growing up. In the present study we describe in details sodium fluoride, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), growth hormone, insulin-like growth factor I, and parathormone and its analogues, describing their mechanism of action and adverse effects. We also show the results of experimental studies and clinical trials in which the mentioned drugs were used. On the basis of available results we are trying to establish the exact position of anabolic agents in pharmacotherapy of osteoporosis.
authors.affiliation: Katedra Farmakologii, Zakład Farmakologii Klinicznej Slaskiej Akademii Medycznej.
authors.forename: Bogusław
authors.initials: B
authors.lastname: Okopień
authors.forename: Robert
authors.initials: R
authors.lastname: Krysiak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Labuzek
authors.forename: Zbigniew Stanisław
authors.initials: ZS
authors.lastname: Herman
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use; D010024:Osteoporosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D045930:Anabolic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010281:Parathyroid Hormone; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D012969:Sodium Fluoride