title: Post-exposure administration of edaravone attenuates noise-induced hearing loss.
abstract: We investigated the effects of the antioxidant edaravone against acoustic trauma in guinea pigs. Edaravone (1.722 x 10(-2) M) was infused into the right ear by an osmotic pump, and the left ear was untreated for control. Animals received edaravone 9 h before (-9 h group, n = 7) and 9 h (+9 h group, n = 8), 21 h (+21 h group, n = 7) and 33 h (+33 h group, n = 4) after 3-h exposure to 130-dB noise. Seven days after noise exposure, we examined the shift in auditory brainstem response thresholds and histopathologic characteristics of the sensory epithelia. The smallest shift in auditory brainstem response threshold and smallest proportion of missing outer hair cells were observed in the +9 h group. This result was supported by immunohistochemical analysis of 4-hydroxy-2-nonenal. Our data suggest that edaravone may be clinically effective in the treatment of acoustic trauma, especially if given within 21 h of noise exposure.
authors.affiliation: Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takemoto
authors.forename: Kazuma
authors.initials: K
authors.lastname: Sugahara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okuda
authors.forename: Takefumi
authors.initials: T
authors.lastname: Mikuriya
authors.forename: Kenji
authors.initials: K
authors.lastname: Takeno
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimogori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000447:Aldehydes / Q000032:analysis; D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001309:Auditory Threshold / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects / Q000503:physiopathology; D002452:Cell Count; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000473:pathology; D034381:Hearing Loss / Q000209:etiology / Q000517:prevention & control*; D007150:Immunohistochemistry; D008297:Male; D009622:Noise / Q000009:adverse effects*; D009925:Organ of Corti / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008517:Phytotherapy
chemical_list: D000447:Aldehydes; D016166:Free Radical Scavengers; C027576:4-hydroxy-2-nonenal; D000077553:Edaravone; D000983:Antipyrine