[A novel hormone found in circulation--endogenous ouabain].
Endogenous ouabain (EO) is a recently found hormone that may be secreted from adrenal cortex. As an endogenous mammalian analogue of cardiac glycosides and an inhibitor of the sodium pump, it regulates the body fluid balance, urine sodium extraction and vasoconstrictive tone, and thus plays an important role in the pathogenesis of hypertension and some other cardiovascular disorders. This articke reviews its biological features, receptor and antibody, detection, effects on diseases and relationship with endothelial cells.
Ren
Yan-Ping
YP
Department of Geriatric Cardiovascular Diseases, First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Lü
Zhuo-Ren
ZR
D000302:Adrenal Cortex / Q000378:metabolism*; D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000209:etiology; D009404:Nephrotic Syndrome / Q000209:etiology; D010042:Ouabain / Q000276:immunology / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000276:immunology / Q000502:physiology*
D000906:Antibodies; C028996:cardiac glycoside receptors; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase