Liposome opsonization.
Adsorption of serum proteins to the liposomal surface plays a critical role in the clearance of liposomes from the blood circulation. In this review, we will discuss the role of the liposomal opsonins proposed so far in liposome clearance. Additional, related topics that will be addressed are the cell-surface receptors that might be involved in liposome elimination from the blood compartment and the effect of poly(ethylene glycol) (PEG) modification on prevention of liposome opsonization.
Yan
Xuedong
X
Department of Cell Biology, Section Liposome Research, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands.
Scherphof
Gerrit L
GL
Kamps
Jan A A M
JA
D000818:Animals; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism*; D009895:Opsonin Proteins / Q000276:immunology / Q000378:metabolism*; D010718:Phosphatidylserines / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000378:metabolism
D008081:Liposomes; D009895:Opsonin Proteins; D010718:Phosphatidylserines; D011956:Receptors, Cell Surface; D011092:Polyethylene Glycols; D003165:Complement System Proteins