Monogenic causes of stroke.
Monogenic disorders account for only a minority of strokes. Yet, they have been particularly helpful in exploring basic disease mechanisms. This article summarizes some recent data on monogenic stroke while focusing on two conditions: CADASIL, as a genetic variant of ischemic small vessel disease, and familial forms of cerebral amyloid angiopathy, which share many properties with sporadic disease.
Dichgans
Martin
M
Neurologische Klinik, Klinikum Grosshadern, Munich, Germany. mdichgans@nefo.med.uni-muenchen.de
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications; D046589:CADASIL / Q000150:complications / Q000235:genetics; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000235:genetics; D003704:Dementia / Q000150:complications; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D020521:Stroke / Q000150:complications / Q000235:genetics*