title: Penetration of piperacillin and tazobactam into inflamed soft tissue of patients with diabetic foot infection.
abstract: We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue.
authors.affiliation: Department of Dermatology, Division of Infectious Diseases, Medical University of Graz, Austria. franz.legat@meduni-graz.at
authors.forename: F J
authors.initials: FJ
authors.lastname: Legat
authors.forename: R
authors.initials: R
authors.lastname: Krause
authors.forename: P
authors.initials: P
authors.lastname: Zenahlik
authors.forename: C
authors.initials: C
authors.lastname: Hoffmann
authors.forename: S
authors.initials: S
authors.lastname: Scholz
authors.forename: W
authors.initials: W
authors.lastname: Salmhofer
authors.forename: J
authors.initials: J
authors.lastname: Tscherpel
authors.forename: T
authors.initials: T
authors.lastname: Tscherpel
authors.forename: H
authors.initials: H
authors.lastname: Kerl
authors.forename: P
authors.initials: P
authors.lastname: Dittrich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D017719:Diabetic Foot / Q000378:metabolism*; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000473:pathology; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D010878:Piperacillin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018461:Soft Tissue Infections / Q000378:metabolism*; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin