[Pharmacological therapy of Cushing's disease].
The curative treatment of Cushing's disease is surgery, mainly transphenoidal surgery. The cure probability is high and the risks or complications are few. However, pharmacotherapy is necessary while localisation of the secreting tumour is not achieved, when there is persistence of hypercortisolism after surgery, or while waiting for effectiveness of radiotherapy. We review the existing drugs, their characteristics, mechanisms of action, doses and specific indications.
Paiva
Isabel
I
Serviço de Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra, Coimbra.
Ribeiro
Cristina
C
D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors; D018377:Neurotransmitter Agents / Q000627:therapeutic use; D047748:Pituitary ACTH Hypersecretion / Q000188:drug therapy*
D018377:Neurotransmitter Agents; D006854:Hydrocortisone