title: Inhibition of class D beta-lactamases by acyl phosphates and phosphonates.
abstract: The susceptibility of typical class D beta-lactamases to inhibition by acyl phosph(on)ates has been determined. To a large degree, these class D enzymes behaved very similarly to the class A TEM beta-lactamase towards these reagents. Dibenzoyl phosphate stood out in both cases as a lead compound towards a new class of effective inhibitors.
authors.affiliation: Department of Chemistry, Wesleyan University, Middletown, CT 06459, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Adediran
authors.forename: Michiyoshi
authors.initials: M
authors.lastname: Nukaga
authors.forename: Stéphane
authors.initials: S
authors.lastname: Baurin
authors.forename: J-M
authors.initials: JM
authors.lastname: Frère
authors.forename: R F
authors.initials: RF
authors.lastname: Pratt
mesh_terms: D006839:Hydrocarbons, Acyclic / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D010710:Phosphates / Q000737:chemistry / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000145:classification*
chemical_list: D006839:Hydrocarbons, Acyclic; D063065:Organophosphonates; D010710:Phosphates; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases