Ionic dialysance: principle and review of its clinical relevance for quantification of hemodialysis efficiency.
Ionic dialysance (D) is an online measured variable now available on several dialysis monitors to evaluate small-solute clearance. Based on conductivity measurements in the inlet and outlet dialysate, the principle of the measurement and the different measurement methods are described. Studies that have evaluated the reliability of ionic dialysance to assess dialysis efficiency are discussed. These studies are divided into two groups: the first comparing ionic dialysance to urea clearance and the second comparing Dt/V to Kt/V(urea), in which the uncertainties of the measurement of V(urea) could have misrepresented the relationship between Dt/V and Kt/V(urea). When Kt/V(urea) via the Daugirdas second-generation equation taking the rebound into account is considered, slight-even nonsignificant-differences are evidenced between Kt/V(urea) and Dt/V. Therefore, ionic dialysance should be considered as a valid measure in future guidelines for dialysis efficiency.
Mercadal
Lucile
L
Department of Nephrology, Pitié-Salpétrière Hospital, Paris, France. lucile.mercadal@psl.ap-hop-paris.fr
Ridel
Christophe
C
Petitclerc
Thierry
T
D001322:Autoanalysis; D015312:Hemodialysis Solutions / Q000737:chemistry*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008954:Models, Biological; D009862:Online Systems; D011786:Quality Control; D006435:Renal Dialysis / Q000592:standards*; D014508:Urea / Q000493:pharmacokinetics
D015312:Hemodialysis Solutions; D014508:Urea