Ovicidal and adulticidal activities of Cinnamomum zeylanicum bark essential oil compounds and related compounds against Pediculus humanus capitis (Anoplura: Pediculicidae).
The toxicity of cinnamon, Cinnamomum zeylanicum, bark essential oil compounds against eggs and adult females of human head louse, Pediculus humanus capitis, was examined using direct contact and vapour phase toxicity bioassays and compared with the lethal activity of their related compounds, benzyl alcohol, cinnamic acid, cinnamyl acetate, 4-hydroxybenzaldehyde and salicylaldehyde, as well as two widely used pediculicides, d-phenothrin and pyrethrum. In a filter-paper contact toxicity bioassay with female lice at 0.25 mg/cm(2), benzaldehyde was 29- and 27-fold more toxic than pyrethrum and d-phenothrin, respectively, as judged by median lethal time (LT(50)) values. Salicylaldehyde was nine and eight times more active than pyrethrum and d-phenothrin, respectively. Pediculicidal activity of linalool was comparable with that of d-phenothrin and pyrethrum. Cinnamomum bark essential oil was slightly less effective than either d-phenothrin or pyrethrum. Benzyl alcohol and (E)-cinnamaldehyde exhibited moderate pediculicidal activity. After 24h of exposure, no hatching was observed with 0.063 mg/cm(2) salicylaldehyde, 0.125 mg/cm(2) benzaldehyde, 0.5mg/cm(2)Cinnamomum bark essential oil, 1.0 mg/cm(2) (E)-cinnamaldehyde, and 1.0 mg/cm(2) benzyl cinnamate. Little or no ovicidal activity was observed with d-phenothrin or pyrethrum. In vapour phase toxicity tests with female lice, benzaldehyde and salicylaldehyde were much more effective in closed containers than in open ones, indicating that the mode of delivery of these compounds was largely due to action in the vapour phase. Neither d-phenothrin nor pyrethrum exhibited fumigant toxicity. Cinnamomum bark essential oil and test compounds described merit further study as potential pediculicides or ovicides for the control of P. h. capitis.
Yang
Young-Cheol
YC
Research Institute, Naturobiotech Co., Ltd., Suwon 441-744, South Korea.
Lee
Hoi-Seon
HS
Lee
Si Hyeock
SH
Clark
J Marshall
JM
Ahn
Young-Joon
YJ
D000818:Animals; D002849:Chromatography, Gas; D002935:Cinnamomum zeylanicum; D006801:Humans; D007305:Insecticide Resistance; D007306:Insecticides / Q000032:analysis / Q000627:therapeutic use*; D010373:Lice Infestations / Q000188:drug therapy*; D009822:Oils, Volatile / Q000032:analysis / Q000627:therapeutic use; D033661:Oocysts; D010374:Pediculus; D008517:Phytotherapy; D024301:Plant Bark; D010938:Plant Oils / Q000032:analysis / Q000627:therapeutic use*; D012536:Scalp Dermatoses / Q000188:drug therapy / Q000469:parasitology; D013057:Spectrum Analysis
D007306:Insecticides; D009822:Oils, Volatile; D010938:Plant Oils