title: Gas chromatography/mass spectrometric analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids for verification of the Chemical Weapons Convention.
abstract: This paper describes the synthesis and gas chromatography/electron ionization mass spectrometric (GC/EI-MS) analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids (DAESAs). These sulfonic acids are important environmental signatures of nerve agent VX and its toxic analogues, hence GC/EI-MS analysis of their methyl esters is of paramount importance for verification of the Chemical Weapons Convention. DAESAs were prepared by condensation of 2-bromoethane sulfonic acid with dialkylamines, and by condensation of dialkylaminoethyl chloride with sodium bisulfite. GC/EI-MS analysis of methyl esters of DAESAs yielded mass spectra; based on these spectra, generalized fragmentation routes are proposed that rationalize most of the characteristic ions.
authors.affiliation: Vertox Laboratory, Defence Research and Development Establishment, Gwalior, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Pardasani
authors.forename: Arvinda K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Meehir
authors.initials: M
authors.lastname: Palit
authors.forename: Purushottam
authors.initials: P
authors.lastname: Shakya
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Kanaujia
authors.forename: K
authors.initials: K
authors.lastname: Sekhar
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Dubey
mesh_terms: D017738:Alkanesulfonic Acids / Q000032:analysis* / Q000138:chemical synthesis; D002618:Chemical Warfare; D002619:Chemical Warfare Agents / Q000032:analysis* / Q000138:chemical synthesis; D004784:Environmental Monitoring / Q000379:methods; D004952:Esters; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008745:Methylation; D009946:Organothiophosphorus Compounds / Q000737:chemistry
chemical_list: D017738:Alkanesulfonic Acids; D002619:Chemical Warfare Agents; D004952:Esters; D009946:Organothiophosphorus Compounds; C009680:VX-agent