title: Nutrigenomics: the impact of biomics technology on nutrition research.
abstract: The interaction between the human body and nutrition is an extremely complex process involving multi-organ physiology with molecular mechanisms on all levels of regulation (genes, gene expression, proteins, metabolites). Only with the recent technology push have nutritional scientists been able to address this complexity. Both the challenges and promises that are offered by the merge of 'biomics' technologies and mechanistic nutrition research are huge, but will eventually evolve in a new nutrition research concept: nutritional systems biology. This review describes the principles and technologies involved in this merge. Using nutrition research examples, including gene expression modulation by carbohydrates and fatty acids, this review discusses applications as well as limitations of genomics, transcriptomics, proteomics, metabolomics, and systems biology. Furthermore, reference is made to gene polymorphisms that underlie individual differences in nutrient utilization, resulting in, e.g., different susceptibility to develop obesity.
authors.affiliation: Centre de Recherche Nestlé, Département de Nutrition, Lausanne, Switzerland.
authors.forename: Irène
authors.initials: I
authors.lastname: Corthésy-Theulaz
authors.forename: Johan T
authors.initials: JT
authors.lastname: den Dunnen
authors.forename: Pascal
authors.initials: P
authors.lastname: Ferré
authors.forename: Jan M W
authors.initials: JM
authors.lastname: Geurts
authors.forename: Michael
authors.initials: M
authors.lastname: Müller
authors.forename: Nico
authors.initials: N
authors.lastname: van Belzen
authors.forename: Ben
authors.initials: B
authors.lastname: van Ommen
mesh_terms: D001709:Biotechnology; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D009747:Nutritional Physiological Phenomena; D011110:Polymorphism, Genetic; D040901:Proteomics