title: [5-Fluorouracil-induced small bowel toxicity in a patient with colorectal cancer].
abstract: 5-Fluorouracil-induced gastro-intestinal toxicity predominantly affects the upper and the lower gastro-intestinal tract. Although 5-fluorouracil (5-FU) can cause severe small-bowel toxicity, this has been reported only in 6 patients with colon carcinoma receiving 5-FU-based therapy. The presentation was extensive ulceration and inflammation of the small bowel with no involvement of the colon. We report another case of this toxicity, and discuss the diagnosis and mechanisms by which 5-FU can induce small-bowel toxicity.
authors.affiliation: Unidad de Oncología, Hospital General Elda, Crta. Elda a Sax s/n, 03600 Elda, Alicante, Spain. cllorcaf@seom.org
authors.forename: Cristina
authors.initials: C
authors.lastname: Llorca Ferrándiz
authors.forename: Gaspar
authors.initials: G
authors.lastname: Esquerdo Galiana
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Cervera Grau
authors.forename: Hugo Claudio
authors.initials: HC
authors.lastname: Briceño García
authors.forename: Juan Vicente
authors.initials: JV
authors.lastname: Calduch Broseta
authors.forename: José
authors.initials: J
authors.lastname: Del Pino Cuadrado
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007079:Ileitis / Q000139:chemically induced*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil