Schizophrenia: an update and review.
Schizophrenia is a common complex disorder characterized by psychosis, cognitive dysfunction and negative symptoms, whose etiology involves interactions between both genetic and environmental vulnerability factors. Recently, ongoing research attempting to elucidate the nature of these vulnerability factors has been generating exciting findings. The advances in understanding of environmental risk factors for mental illnesses and in genetic research into mental illnesses will be reviewed. Limitations of the findings and implications of these advances for genetic counseling practice will also be discussed.
Austin
Jehannine
J
Department of Psychiatry, University of British Columbia, Vancouver, B.C., Canada. jcaustin@interchange.ubc.ca
D001723:Birth Rate; D002352:Carrier Proteins / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D003605:D-Amino-Acid Oxidase / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D020890:Neuregulin-1; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology; D020710:RGS Proteins / Q000235:genetics; D050637:Receptors, Dopamine D3 / Q000235:genetics; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012621:Seasons; D013315:Stress, Psychological / Q000523:psychology
D002352:Carrier Proteins; C493593:DRD3 protein, human; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; D020710:RGS Proteins; D050637:Receptors, Dopamine D3; C098799:RGS4 protein; C417983:DAO protein, human; D003605:D-Amino-Acid Oxidase; D002394:Catechol O-Methyltransferase