[Stem cell therapy for chronic cardiac insufficiency--therapy of the future?].
The incidence of chronic cardiac insufficiency is constantly increasing. However, the current therapeutic possibilities during the terminal stage are limited by a lack of donor organs. For this reason, stem cell therapy is seen as a potent therapeutic option for the future. Catheter application or cytokine-mediated mobilization of autologous adult stem cells is for acute myocardial infarction safe and potentially effective; however, for chronic cardiac insufficiency, the successes have not yet been verifiable. Hence, embryonic stem cells offer a therapeutic option that cannot be ignored: These cells are pluripotent and are, theoretically, able to continue dividing in cell culture indefinitely. Through "tissue engineering" they could generate new myocardium that could be transplanted into patients suffering from chronic cardiac insufficiency to support the pump function.
Franz
W M
WM
Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Grosshadern. wolfgang.franz@med.uni-muenchen.de
Theiss
H D
HD
Steinbeck
G
G
D000818:Animals; D005544:Forecasting; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D023822:Tissue Engineering