Virally encoded chemokine binding proteins.
Virus-encoded immune evasion mechanisms provide information on viral pathogenesis and offer a unique opportunity to identify new strategies of immune modulation. Secreted proteins that bind a broad range of chemokines have been identified in recent years in poxviruses and herpesviruses. We discuss the properties of these viral chemokine inhibitors and their potential as new therapeutics to treat human inflammatory diseases.
Webb
Louise M C
LM
Department of Medicine and Division of Virology, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ Eden 28049 Madrid, Spain.
Alcami
Antonio
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D014777:Virus Diseases / Q000378:metabolism / Q000473:pathology; D014780:Viruses / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D018925:Chemokines; D014764:Viral Proteins