title: [Prevalence of thyroid autoimmunity in a group of patients with type 1 diabetes mellitus in Londrina, PR].
abstract: Thyroid autoimmunity is a frequent comorbid condition subjects with in type 1 diabetes mellitus (DM1). We evaluated the prevalence of antithyroid autoantibodies (antimicrosomal, antithyroglobulin and antithyroid peroxidase), in addition to clinical (gender, age, DM duration) and laboratory (TSH, HbA1) characteristics of 101 patients (mean age 20 +/- 9.6 years; 62 female) followed at the HC/UEL.
  
  
  RESULTS
  Autoantibodies were found in 31 subjects (30.7%). In the age group <12 years, 15% had thyroid antibodies; from 12 to 18 years, 32%, and >18 years, 35.7% (p= 0.22). Among the patients with positive antibodies, 40% had some thyroid dysfunction vs only 4.4% of those without antibodies (p<0.001). The average TSH was higher in the positive than in negative group (3.75 and 2.32microU/mL, respectively; p= 0.01).
  
  
  CONCLUSIONS
  The prevalence of thyroid antibodies was 30.7%, in accordance to the literature.
authors.affiliation: Disciplina de Endocrinologia, Centro de Ciências da Saúde, Universidade Estadual de Londrina, PR. ottonraffo@hotmail.com
authors.forename: Otton Luis Raffo
authors.initials: OL
authors.lastname: Souza
authors.forename: Leandro Arthur
authors.initials: LA
authors.lastname: Diehl
authors.forename: Lineu Domingos
authors.initials: LD
authors.lastname: Carleto
authors.forename: Valdinei
authors.initials: V
authors.lastname: Garcia
authors.forename: Alexandre José F
authors.initials: AJ
authors.lastname: Carrilho
authors.forename: Maria Leocádia
authors.initials: ML
authors.lastname: de Oliveira
authors.forename: Henriqueta G G
authors.initials: HG
authors.lastname: de Almeida
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D001323:Autoantibodies / Q000097:blood*; D001938:Brazil; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000276:immunology; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D010544:Peroxidases