[Effect of tamoxifen in lipids of diabetic rats induced by streptozotocin].
OBJECTIVE
To evaluate the effect of tamoxifen in the lipidic and renal profile in diabetic and control rats.


METHODS
40 female Wistar rats had been used (180-220g corporal weight), divided randomly in 4 groups: C (n = 10, received vehicle), T (n = 10, treated with tamoxifen, 0.3mg/kg/day), D (n = 10, diabetic induced by streptozotocin, 45mg/Kg) and DT (n = 10, diabetic treated with tamoxifen). Glucose, total cholesterol, triglyceride, total proteins, albumin, urea and creatinin were analyzed using Labtest Kits through the Cobas Mira analyzer (Germany, 1996).


RESULTS
Group T presented a reduction of total cholesterol and triglyceride in relation to C, and group D an increase in relation to the other ones. About the total proteins it was observed an increasing in Group T in relation to C. The albumin diminished in groups D and DT in relation to C and T. The urea levels increased in groups D and DT in relation to C and T.


CONCLUSIONS
In relation to the lipidic profile it was evidenced that during the period of 60 days the treatment with tamoxifen promoted a reduction in cholesterol and triglyceride levels in the serum, even associated to the condition of Diabetes mellitus.
Nogueira Júnior
Francisco C
FC
Farmacêutico Bioquímica Graduado pela UFRN, Natal - RN, Brasil.
Coelho
Daniel A
DA
Almeida
Maria Margareth C
MM
Silva
Teresa Cristina P
TC
Ferreira
Elaine Cristina S
EC
Macedo
Ulisvaldo Bruno O
UB
Neto
Francisco Paulo F
FP
Brandão Neto
José
J
Almeida
Maria das Graças
Md
de Rezende
Adriana Augusto
AA
D000418:Albumins / Q000032:analysis; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects*; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013629:Tamoxifen / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*; D014508:Urea / Q000097:blood
D000418:Albumins; D004965:Estrogen Antagonists; D011506:Proteins; D014280:Triglycerides; D013629:Tamoxifen; D013311:Streptozocin; D014508:Urea; D002784:Cholesterol; D003404:Creatinine