title: Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia.
abstract: Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2 LTR DNA). Although total HIV DNA was detected in 60 2 LTR DNA-negative samples, the absence of 2 LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.
authors.affiliation: Section of Microbiology, School of Medicine, University of Genova, Largo Rosanna Benzi, 10, 16132 Genova (EC), Italy.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McDermott
authors.forename: Isabella
authors.initials: I
authors.lastname: Martini
authors.forename: Davide
authors.initials: D
authors.lastname: Ferrari
authors.forename: Francesca
authors.initials: F
authors.lastname: Bertolotti
authors.forename: Claudio
authors.initials: C
authors.lastname: Giacomazzi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Murdaca
authors.forename: Francesco
authors.initials: F
authors.lastname: Puppo
authors.forename: Francesco
authors.initials: F
authors.lastname: Indiveri
authors.forename: Oliviero E
authors.initials: OE
authors.lastname: Varnier
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D004279:DNA, Viral / Q000097:blood* / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy; D016325:HIV Long Terminal Repeat / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D014766:Viremia / Q000188:drug therapy* / Q000821:virology; D016662:Virus Integration; D014779:Virus Replication / Q000187:drug effects
chemical_list: D004279:DNA, Viral