title: Mycosis fungoides associated with intestinal mucosa-associated lymphoid tissue lymphoma.
abstract: Coexistence of cutaneous T-cell lymphoma (CTCL) and a B-cell malignancy is rare. We report a case of mycosis fungoides (MF) associated with intestinal mucosa-associated lymphoid tissue (MALT) lymphoma, which is a low-grade B-cell lymphoma of marginal cell origin. To the best of our knowledge, there have been only two cases of coexistent CTCL and MALT lymphoma, and this is the first case with typical MF and intestinal MALT lymphoma. The coexistence in our case might be coincidental, but genetic predisposition and the immunoregulatory capacity of neoplastic T lymphocytes may be factors contributing to this association.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. OMATSUH-DER@h.u-tokyo.ac.jp
authors.forename: Hanako
authors.initials: H
authors.lastname: Ohmatsu
authors.forename: Hidehisa
authors.initials: H
authors.lastname: Saeki
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujita
authors.forename: Keiko
authors.initials: K
authors.lastname: Toyoma
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Akihiko
authors.initials: A
authors.lastname: Asahina
authors.forename: Shigeo
authors.initials: S
authors.lastname: Masuda
authors.forename: Hisamaru
authors.initials: H
authors.lastname: Hirai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nagawa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000032:analysis; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D007143:Immunoglobulin Heavy Chains; D016693:Receptors, Antigen, T-Cell, alpha-beta; D017493:Leukocyte Common Antigens