Comparative genomic hybridization analysis of pediatric adamantinomatous craniopharyngiomas and a review of the literature.
OBJECTIVE
The purpose of this study was to examine chromosomal gains and losses in 11 pediatric adamantinomatous craniopharyngiomas by using comparative genomic hybridization (CGH), as well as to review the cytogenetic literature that has contributed to the characterization of these tumors. One source of confusion in the cytogenetic and CGH literature concerning craniopharyngioma is that the authors of most studies fail to distinguish between pediatric and later-onset forms of the disease. Thus, this study was focused on pediatric craniopharyngioma.


METHODS
To determine an overview of the genetic events leading to the development of these tumors, 10 adamantinomatous craniopharyngiomas were analyzed using CGH; none of the tumor specimens demonstrated gains or losses of DNA sequence.


CONCLUSIONS
In view of these findings as well as those published in the majority of previous cytogenetic studies of craniopharyngiomas, the authors conclude that the recurrent acquisition of chromosomal imbalances does not play a major role in tumorigenesis and that chromosomal gains and losses are a relatively rare event in primary tumors of pediatric origin.
Yoshimoto
Maisa
M
Instituto de Oncologia Pediátrica, Grupo de Apoio ao Adolescente e à Criança corn Câncer São Paulo, Brazil.
de Toledo
Sílvia Regina Caminada
SR
da Silva
Nasjla Saba
NS
Bayani
Jane
J
Bertozzi
Ana Paula Antunes Pascalicchio
AP
Stavale
João Norberto
JN
Cavalheiro
Sergio
S
Andrade
Joyce Anderson Duffles
JA
Zielenska
Maria
M
Squire
Jeremy A
JA
D000293:Adolescent; D017668:Age of Onset; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D043171:Chromosomal Instability; D002869:Chromosome Aberrations; D003397:Craniopharyngioma / Q000235:genetics*; D003582:Cytogenetics; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D010911:Pituitary Neoplasms / Q000235:genetics*; D012008:Recurrence
D004273:DNA, Neoplasm