title: Compounds structurally related to tamoxifen as openers of large-conductance calcium-activated K+ channel.
abstract: We found that a variety of compounds containing partial structures of tamoxifen showed activity as chemical modulators of large-conductance calcium-activated K+ channels (BK channels).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sha
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Tashima
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Toriumi
authors.forename: Satomi
authors.initials: S
authors.lastname: Adachi-Akahane
authors.forename: Taro
authors.initials: T
authors.lastname: Nonomura
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ohwada
mesh_terms: D004396:Coloring Agents / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004396:Coloring Agents; D024681:Potassium Channels, Calcium-Activated; D013629:Tamoxifen