Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats.
During the prenatal period, the development of individual is influenced by the environmental factors. In the present study, the influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats was investigated. The exposure to the noise during pregnancy caused growth retardation, decreased neurogenesis in the hippocampus, and impaired spatial learning ability in pups. The exposure to music during pregnancy, on the other hand, caused increased neurogenesis in the hippocampus and enhanced spatial learning ability in pups. The present study has shown the importance of the prenatal environmental conditions for the cognition and brain development.
Kim
Hong
H
Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
Lee
Myoung-Hwa
MH
Chang
Hyun-Kyung
HK
Lee
Taeck-Hyun
TH
Lee
Hee-Hyuk
HH
Shin
Min-Chul
MC
Shin
Mal-Soon
MS
Won
Ran
R
Shin
Hye-Sook
HS
Kim
Chang-Ju
CJ
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D001835:Body Weight / Q000502:physiology; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D009146:Music; D009474:Neurons / Q000502:physiology*; D009622:Noise / Q000009:adverse effects*; D038081:Organogenesis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013037:Spatial Behavior / Q000502:physiology*; D013997:Time Factors
D001973:Bromodeoxyuridine