[Emphasize the role of bioactive small molecules in the homeostasis regulation of cardiovascular system].
Bioactive small molecules play a crucial role in maintaining structural and functional homeostasis of cardiovascular system. However, systemic research pattern is rare because of the multiple forms, diverse effects and complicated interaction of these molecules. Therefore firstly, they can be classified into different single 'families' according to their internal relationships. Secondly, studies may be focused on the network of members within each 'family' as well as network among different 'families', especially the physiological and pathological significance of each member in the cardiovascular diseases. Lastly, efforts should be made to establish a primary and simple regulation network as the strategy of researches on biology of cardiovascular systems, and to promote the transition to a network covering more complicated multiplex 'families', even the whole body.
Tang
Chao-Shu
CS
Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Bejing 100083, China.
Pu
Dan
D
D001688:Biological Products / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000187:drug effects; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry; D011955:Receptors, Drug / Q000032:analysis
D001688:Biological Products; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D011955:Receptors, Drug