title: Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates.
abstract: Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.
authors.affiliation: Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. mzovko@pharma.hr
authors.forename: Marijana
authors.initials: M
authors.lastname: Zovko
authors.forename: Monika
authors.initials: M
authors.lastname: Barbarić
authors.forename: Branka
authors.initials: B
authors.lastname: Zorc
authors.forename: Anita
authors.initials: A
authors.lastname: Hafner
authors.forename: Jelena
authors.initials: J
authors.lastname: Filipović-Grcić
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D005279:Fenoprofen / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015248:Gemfibrozil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D008298:Maleates / Q000737:chemistry; D011355:Prodrugs; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013343:Styrenes / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000960:Hypolipidemic Agents; D008298:Maleates; D011355:Prodrugs; D013343:Styrenes; C030272:maleic acid; D015248:Gemfibrozil; D005279:Fenoprofen