Identification of an HptB-mediated multi-step phosphorelay in Pseudomonas aeruginosa PAO1.
We herein demonstrate that the hybrid sensor PA1611 carries out specific signal transduction, through HptB (PA3345), to the response regulator PA3346 in Pseudomonas aeruginosa PAO1. As assessed by phenotypic changes in the hptB deletion mutant, the pathway is likely to be involved in the regulation of flagellar activity, the chemotaxis response, twitching motility, and biofilm formation in the bacteria.
Lin
Ching-Ting
CT
Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsin Chu 30050, Taiwan, Republic of China.
Huang
Ying-Jung
YJ
Chu
Pei-Hsuan
PH
Hsu
Jye-Lin
JL
Huang
Chih-Hsiang
CH
Peng
Hwei-Ling
HL
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development; D002633:Chemotaxis / Q000502:physiology; D005407:Flagella / Q000502:physiology*; D017353:Gene Deletion; D023061:Gene Order; D009068:Movement; D005810:Multigene Family; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
D001426:Bacterial Proteins