title: Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy.
abstract: This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth. Hydroxyzine plasma concentrations were measured by liquid chromatography-mass spectrometry. Neurological symptoms with low neonatal concentrations of hydroxyzine may be due to a withdrawal syndrome. According to previous observations and this case report, clinicians should be warned of this possible rare neurological complication of hydroxyzine in neonates born from long term treated mothers.
authors.affiliation: Paediatric Pharmacology and Pharmacogenetic, Hôpital Robert debré, 48 boulevard Sérurier, Paris, France. raphael.serreau@rdb.aphp.fr
authors.forename: Raphaël
authors.initials: R
authors.lastname: Serreau
authors.forename: Meriem
authors.initials: M
authors.lastname: Komiha
authors.forename: Florence
authors.initials: F
authors.lastname: Blanc
authors.forename: François
authors.initials: F
authors.lastname: Guillot
authors.forename: Evelyne
authors.initials: E
authors.lastname: Jacqz-Aigrain
mesh_terms: D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012640:Seizures / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
chemical_list: D006634:Histamine H1 Antagonists; D006919:Hydroxyzine