Production of Ac-225 from Th-229 for targeted alpha therapy.
This work describes a method for the separation and purification of Ac-225 from a Th-229 source. The procedure is based on the combination of ion exchange and extraction chromatographic methods in nitric acid media and allows the preparation of carrier-free, clinical grade Ac-225 with an overall yield exceeding 95%. Quality control of the product is performed using radiometric (alpha, gamma spectrometry) and mass spectrometric methods. The Ac-225 product can be loaded on a radionuclide generator for the preparation of Bi-213 for preclinical and clinical studies of targeted alpha therapy of cancer and infectious diseases.
Apostolidis
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European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe, Germany.
Molinet
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R
Rasmussen
G
G
Morgenstern
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A
D000186:Actinium / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use*; D000838:Anions / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry; D013793:Thallium / Q000737:chemistry* / Q000627:therapeutic use*
D000838:Anions; D011868:Radioisotopes; D013793:Thallium; D000186:Actinium