title: Alkaloids from the sponge Monanchora unguifera.
abstract: The bioassay-guided fractionation of the cytotoxic crude gum obtained from the Caribbean sponge Monanchora unguifera led to the isolation and characterization of the new compounds batzelladine J (1) and crambescidic acid (2) in addition to known guanidine alkaloids ptilomycalin A (3a), ptilocaulin (4), and isoptilocaulin (5). The structures of the compounds were elucidated by interpretation of the 1D and 2D NMR experiments. The chemotaxonomic implications of these findings are discussed.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822, USA. winklet.gallimore@uwimona.edu.jm
authors.forename: Winklet A
authors.initials: WA
authors.lastname: Gallimore
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scheuer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006146:Guanidines; C505318:batzelladine J; C505319:crambescidic acid