title: Epigallocatechin gallate inhibits biofilm formation by ocular staphylococcal isolates.
abstract: Epigallocatechin gallate (EGCg), the main polyphenol component of green tea, has several antibacterial properties. Here we show that sub-MICs of EGCg appear to decrease slime production, therefore inhibiting biofilm formation by ocular staphylococcal isolates previously characterized for the presence of ica genes by the Congo red agar plate assay and for adhesion to microtiter plates.
authors.affiliation: Direzione Ricerca Sviluppo & Innovazione, SIFI SpA, Catania, Italy.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Blanco
authors.forename: Andrea
authors.initials: A
authors.lastname: Sudano-Roccaro
authors.forename: Giovanna Carmela
authors.initials: GC
authors.lastname: Spoto
authors.forename: Antonia
authors.initials: A
authors.lastname: Nostro
authors.forename: Dario
authors.initials: D
authors.lastname: Rusciano
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005123:Eye / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000302:isolation & purification / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D002392:Catechin; C045651:epigallocatechin gallate