title: Urinary tobacco-specific nitrosamines and 4-aminobiphenyl hemoglobin adducts measured in smokers of either regular or light cigarettes.
abstract: Cigarette brands may differ in their reported yields of "tar" as determined by the Federal Trade Commission smoking-machine method. Brands with relatively lower tar and nicotine yields often are described as light cigarettes. Smokers of light cigarettes generally maintain a nicotine intake comparable to that of smokers of regular cigarettes through compensatory smoking behaviors, but similar data have not been reported for carcinogen biomarkers. In the present study we measured serum cotinine concentrations (a marker of nicotine exposure), urinary levels of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, a tobacco-specific nitrosamine [TSNA]), and hemoglobin adducts of 4-aminobiphenyl (4-ABP) in 150 smokers of either regular or light cigarettes. The TSNA and aromatic amines are known carcinogens in tobacco smoke. Multiple regression models were developed for each of the analytes and used to calculate adjusted geometric means. We found no significant differences in the levels of these biomarkers between customary users of light and regular cigarettes. Thus the concentrations of the carcinogen biomarkers NNAL and 4-ABP in the smokers who regularly smoked light cigarettes were essentially the same as those in the smokers who chose regular cigarettes.
authors.affiliation: Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. jtb2@cdc.gov
authors.forename: John T
authors.initials: JT
authors.lastname: Bernert
authors.forename: Ram B
authors.initials: RB
authors.lastname: Jain
authors.forename: James L
authors.initials: JL
authors.lastname: Pirkle
authors.forename: Lanqing
authors.initials: L
authors.lastname: Wang
authors.forename: Barbara B
authors.initials: BB
authors.lastname: Miller
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Sampson
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002273:Carcinogens / Q000032:analysis*; D003367:Cotinine / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009602:Nitrosamines / Q000652:urine*; D011725:Pyridines / Q000652:urine*; D012907:Smoking
chemical_list: D015415:Biomarkers; D002273:Carcinogens; D006454:Hemoglobins; D009602:Nitrosamines; D011725:Pyridines; C099565:4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol; D003367:Cotinine