title: [Relationship between fatal severe from hepatitis occurred during chronic hepatitis B and superinfections of hepatotropic B e system status].
abstract: OBJECTIVE
  To clarify the relationship between fatal severe form hepatitis occurred during chronic hepatitis B and superinfections of hepatitis A, C, D or E virus as well as hepatitis B e system status and to adopt corresponding measures to reduce the mortality of chronic hepatitis B.
  
  
  METHODS
  This study detected the superinfections with hepatitis A, C, D or E virus and hepatitis B e system status in 219 patients with fatal severe form hepatitis occurred during chronic hepatitis B by enzyme linked immunosorbent assay.
  
  
  RESULTS
  The superinfections with hepatitis A, C, D or E virus were found in 1.4% (3/219), 9.6% (21/219), 1.8% (4/219) and 30.1% (66/219) of the patients, respectively, altogether 42.9% (94/219); hepatitis E was prominent and steady in superinfection rate in recent ten years. The causes of 57.1% (125/219) patients were not clear. The positive rate of HBeAg and anti-HBe were 17.0% (16/94) and 54.2% (51/94) in the group of superinfections with hepatitis A, C, D or E virus; and were 27.2% (34/125) and 47.2% (59/125) in the group with unknown causes, respectively.
  
  
  CONCLUSIONS
  These results suggested that the patients with superinfections reached 42.9% (94/219), and the superinfections may be a part of causes of fatal severe form hepatitis, and the mortality of chronic hepatitis B may be decreased by strict food sanitation and use of safe blood products. There were no significant relation between hepatitis B e antigen seroconversion and the fatal severe form hepatitis occurred during chronic hepatitis B.
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Ke
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Lin
authors.forename: Yi-long
authors.initials: YL
authors.lastname: Ye
authors.forename: Jing
authors.initials: J
authors.lastname: Lai
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Li
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology; D030041:Hepatitis A virus / Q000235:genetics / Q000502:physiology; D006512:Hepatitis B Core Antigens / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000401:mortality / Q000821:virology*; D003698:Hepatitis Delta Virus / Q000235:genetics / Q000502:physiology; D016752:Hepatitis E virus / Q000235:genetics / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D015163:Superinfection / Q000821:virology*; D015996:Survival Rate
chemical_list: D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens