title: Resistance to nonnucleoside reverse-transcriptase inhibitors and prevalence of HIV type 1 non-B subtypes are increasing among persons with recent infection in Spain.
abstract: The prevalence of drug resistance mutations was 12.1% among 198 persons who experienced human immunodeficiency virus (HIV) seroconversion identified in Spain during 1997-2004. There was a significant increase of K103N and of non-B subtypes over time. Transmission of HIV infection around the time of seroconversion was shown in 8 couples and in 2 clusters of 3 individuals.
authors.affiliation: Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
authors.forename: Carmen
authors.initials: C
authors.lastname: Rodriguez
authors.forename: Javier
authors.initials: J
authors.lastname: Colomina
authors.forename: Concepcion
authors.initials: C
authors.lastname: Tuset
authors.forename: Federico
authors.initials: F
authors.lastname: Garcia
authors.forename: Jose M
authors.initials: JM
authors.lastname: Eiros
authors.forename: Angelica
authors.initials: A
authors.lastname: Corral
authors.forename: Pilar
authors.initials: P
authors.lastname: Leiva
authors.forename: Jesus
authors.initials: J
authors.lastname: Aguero
authors.forename: Julian
authors.initials: J
authors.lastname: Torre-Cisneros
authors.forename: Jose
authors.initials: J
authors.lastname: Pedreira
authors.forename: Isabel
authors.initials: I
authors.lastname: Viciana
authors.forename: Jorge
authors.initials: J
authors.lastname: del Romero
authors.forename: Ana
authors.initials: A
authors.lastname: Saez
authors.forename: Raul
authors.initials: R
authors.lastname: Ortiz de Lejarazu
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D015995:Prevalence; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
chemical_list: D018894:Reverse Transcriptase Inhibitors