title: [Major hepatectomy for metastasis of colorectal cancer improves survival in the elderly].
abstract: OBJECTIVE
  Assessing impact of major liver resection (LR) for hepatic metastasis of colorectal cancer (HMCC) on post operative courses and long term survival in the elderly.
  
  
  METHODS
  Thirty-three consecutive patients aged over 70 years-old were treated in our institution for up to 3 resectable metachronous HMCC. Fifteen patients had major LR (9 right hepatectomy, 3 extended right hepatectomy, 3 left hepatectomy) without pre or postoperative chemotherapy (group 1) and 18 patients were exclusively treated by chemotherapy (group 2) because of high ASA score (ASA 3) or patients refusal.
  
  
  RESULTS
  No patients died of another cause that colorectal cancer disease during observation time. All patients of group 2 died during observation time. Post operative mortality and morbidity of group 1 were respectively 0% and 33%. Survival at 1 and 2 years of group 1-2 were respectively 73-50% (P=0,04) and 47-15% (P=0,05). Median survival of group 1 and 2 were respectively 22 and 12 months (P=0,03).
  
  
  CONCLUSIONS
  Major LR for HMCC could be proposed regardless the age. High ASA score, multiple (more than 4) metastasis location, evolutive disease could justify an exclusive medical approach.
authors.affiliation: Département de chirurgie oncologique, institut Paoli-Calmettes, 232, boulevard Sainte-Marguerite, 13009 Marseille, France. oturrini@yahoo.fr
authors.forename: O
authors.initials: O
authors.lastname: Turrini
authors.forename: J
authors.initials: J
authors.lastname: Guiramand
authors.forename: V
authors.initials: V
authors.lastname: Moutardier
authors.forename: F
authors.initials: F
authors.lastname: Viret
authors.forename: E
authors.initials: E
authors.lastname: Bories
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
authors.forename: D
authors.initials: D
authors.lastname: Mokart
authors.forename: J L
authors.initials: JL
authors.lastname: Blache
authors.forename: J R
authors.initials: JR
authors.lastname: Delpero
mesh_terms: D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery*; D008297:Male; D009017:Morbidity; D011379:Prognosis; D016019:Survival Analysis