Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.
Manger
Michael
M
Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
Scheck
Michael
M
Prinz
Heino
H
von Kries
Jens Peter
JP
Langer
Thomas
T
Saxena
Krishna
K
Schwalbe
Harald
H
Fürstner
Alois
A
Rademann
Jörg
J
Waldmann
Herbert
H
D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D019151:Peptide Library; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011758:Pyrroles / Q000494:pharmacology; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
D001426:Bacterial Proteins; D047630:Depsipeptides; D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; C414465:MptpA protein, Mycobacterium tuberculosis; D019151:Peptide Library; D011758:Pyrroles; D011993:Recombinant Fusion Proteins; C408872:roseophilin; D017027:Protein Tyrosine Phosphatases