title: Hypertrophic osteoarthropathy in two children with cholestatic hepatic disease.
abstract: OBJECTIVE
  To describe two children with hypertrophic osteoarthropathy associated with cholestatic hepatic disease. Both patients suffered from chronic progressive cholestatic liver disease and developed digital clubbing, polyarthritis and periosteal reaction. In one of them, clinical and radiological features normalized after liver transplant.
  
  
  CONCLUSIONS
  Hepatic hypertrophic osteoarthropathy is a rare disabling condition that responds poorly to conservative management, while liver transplantation appears to be the only effective therapeutic intervention.
authors.affiliation: Department of Immunology, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Katsicas
authors.forename: M
authors.initials: M
authors.lastname: Ciocca
authors.forename: M
authors.initials: M
authors.lastname: Rosanova
authors.forename: R
authors.initials: R
authors.lastname: Russo
mesh_terms: D000293:Adolescent; D002648:Child; D002779:Cholestasis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011859:Radiography; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome