title: Cytotoxic limonoids from Brazilian Melia azedarach.
abstract: Three new C-seco limonoids (1-3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: Honglei
authors.initials: H
authors.lastname: Zhou
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hamazaki
authors.forename: Jose Domingos
authors.initials: JD
authors.lastname: Fontana
authors.forename: Hironobu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Carolina Bueno
authors.initials: CB
authors.lastname: Wandscheer
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D001938:Brazil; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D031586:Melia azedarach / Q000737:chemistry*; D008968:Molecular Conformation; D012015:Reference Standards
chemical_list: D036701:Limonins