Serial autofluorescence imaging over two years following indocyanine green-assisted internal limiting membrane peel for macular hole.
A 65-year-old patient with an idiopathic full-thickness macular hole underwent a vitrectomy, inner limiting membrane (ILM) peel and gas tamponade. The ILM was stained using 0.5% indocyanine green (ICG). Postoperative autofluorescence imaging shows a central focal hyperfluorescence surrounded by a perifoveal hypofluoresecnt area corresponding to the dyed and peeled ILM. Serial autofluorescence images showed progressive decrease in staining until 2 years later when no signs of ICG autofluorescence were apparent. The visual acuity for this patient improved two Snellen lines from 6/36 to 6/18 at 2 years. ICG may not be clinically toxic as is currently feared.
Kersey
Thomas L
TL
Bolton
Anne
A
Patel
C K
CK
D000368:Aged; D001485:Basement Membrane / Q000473:pathology / Q000601:surgery; D004396:Coloring Agents; D003952:Diagnostic Imaging; D005260:Female; D005453:Fluorescence; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green; D016684:Prone Position; D012167:Retinal Perforations / Q000175:diagnosis* / Q000601:surgery; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D041623:Tomography, Optical Coherence; D014821:Vitrectomy
D004396:Coloring Agents; D007208:Indocyanine Green; D013459:Sulfur Hexafluoride