Successful treatment of lymphadenosis benigna cutis with topical photodynamic therapy with delta-aminolevulinic acid.
BACKGROUND
Photodynamic therapy (PDT) using topical delta-aminolevulinic acid (ALA) has been used for nonmelanoma skin cancers, including malignant cutaneous T-cell lymphomas. Moreover, PDT has been tried for benign inflammatory or infectious skin lesions.


OBJECTIVE
To evaluate the effects of ALA-PDT on skin lesions of lymphadenosis benigna cutis (LABC).


METHODS
Two 16-year-old females with solitary and infiltrated nodules were treated 5 times with topical ALA-PDT.


RESULTS
Both patients responded well and showed dramatic clinical and histopathological improvement without visible scars.


CONCLUSIONS
The results confirm that topical ALA-PDT is an effective and safe modality for the treatment of LABC, and that such treatment may be cosmetically beneficial.
Takeda
Hitoshi
H
Department of Dermatology, Hirosaki University School of Medicine, Japan.
Kaneko
Takahide
T
Harada
Ken
K
Matsuzaki
Yasushi
Y
Nakano
Hajime
H
Hanada
Katsumi
K
D000293:Adolescent; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D019310:Pseudolymphoma / Q000150:complications / Q000188:drug therapy*; D012871:Skin Diseases / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid