Resistance to nonnucleoside reverse-transcriptase inhibitors and prevalence of HIV type 1 non-B subtypes are increasing among persons with recent infection in Spain.
The prevalence of drug resistance mutations was 12.1% among 198 persons who experienced human immunodeficiency virus (HIV) seroconversion identified in Spain during 1997-2004. There was a significant increase of K103N and of non-B subtypes over time. Transmission of HIV infection around the time of seroconversion was shown in 8 couples and in 2 clusters of 3 individuals.
de Mendoza
Carmen
C
Service of Infectious Diseases, Hospital Carlos III, Madrid, Spain.
Rodriguez
Carmen
C
Colomina
Javier
J
Tuset
Concepcion
C
Garcia
Federico
F
Eiros
Jose M
JM
Corral
Angelica
A
Leiva
Pilar
P
Aguero
Jesus
J
Torre-Cisneros
Julian
J
Pedreira
Jose
J
Viciana
Isabel
I
del Romero
Jorge
J
Saez
Ana
A
Ortiz de Lejarazu
Raul
R
Soriano
Vincent
V
D000328:Adult; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D015995:Prevalence; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
D018894:Reverse Transcriptase Inhibitors