title: Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder.
abstract: Donepezil, 5 mg/d for 6 wk then 10 mg/d for 6 wk, and placebo daily for 12 wk in a double-blind cross-over paradigm, was added to the therapeutic regimen of 13 patients with schizophrenia or schizoaffective disorders, clinically stable on atypical antipsychotic medications. Patients had varying degrees of depressive symptoms, ranging from no depression to clinically significant depression. There was no worsening or induction of depression in individual patients or the group as a whole. In addition there was a statistically significant antidepressant effect in the group as a whole during the donepezil condition and a clinically significant antidepressant effect in the patients with clinically significant depressive symptoms, although there were not enough depressed patients in the group to conclude that donepezil may have antidepressant effects. Thus, in this study, donepezil did not induce or worsen depressive symptoms in schizophrenic and schizoaffective disorder patients.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, CA 94143-0984, USA. craigr@lppi.ucsf.edu
authors.forename: S Craig
authors.initials: SC
authors.lastname: Risch
authors.forename: Michael D
authors.initials: MD
authors.lastname: Horner
authors.forename: Susan R
authors.initials: SR
authors.lastname: McGurk
authors.forename: Simmy
authors.initials: S
authors.lastname: Palecko
authors.forename: John S
authors.initials: JS
authors.lastname: Markowitz
authors.forename: Ziad
authors.initials: Z
authors.lastname: Nahas
authors.forename: C Lindsay
authors.initials: CL
authors.lastname: DeVane
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D000704:Analysis of Variance; D018592:Cross-Over Studies; D000077265:Donepezil; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000503:physiopathology; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil