Use of iso-osmolar nonionic dimeric contrast media in multidetector row computed tomography angiography for patients with renal impairment.
OBJECTIVE
We wanted to determine the rate of contrast-induced nephropathy (CIN) caused in patients with renal impairment undergoing multidetector row computed tomography (MDCT) angiography with intravenous administration of iso-osmolar dimeric contrast media (iodixanol).


METHODS
The first consecutive 100 patients referred to CT with a serum creatinine level (SCr) between 1.5 and 6 mg/dL were enrolled in the study. Serum creatinine also was determined on days 3 and 7 after the intravenous administration of 100 mL of iodixanol 270 with 5 mL/s. A CIN was considered if variation of SCr on day 3 was >0.5 mg/dl above baseline.


RESULTS
Nine patients developed a CIN after MDCT angiography; 7 of them recovered completely by day 7, and the remaining 2 showed elevated SCr on day 7 but did not develop renal failure during their hospital stay.


CONCLUSIONS
MDCT angiography performed in patients with impaired renal function with iodixanol may result in CIN but complete recovery is probable.
Becker
Christoph R
CR
Department of Clinical Radiology, University Hospital Munich, Grosshadern, Munich, Germany. christoph.becker@med.uni-muenchen.de
Reiser
Maximilian F
MF
D000368:Aged; D000792:Angiography / Q000009:adverse effects* / Q000295:instrumentation; D015331:Cohort Studies; D003287:Contrast Media / Q000009:adverse effects; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D009401:Nephrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000009:adverse effects* / Q000295:instrumentation; D014159:Transducers; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol