title: Formulation optimization of photocrosslinked polyacrylic acid modified with 2-hydroxyethyl methacrylate hydrogel as an adhesive for a dermatological patch.
abstract: A photopolymerization technique was applied in the preparation of a hydrogel composed of polyacrylic acid (PAA) in which 2-hydroxyethyl methacrylate (HEMA) was modified. The formulation of photocrosslinked PAA modified with HEMA hydrogel as an adhesive for a dermatological patch was optimized based on the simultaneous optimization technique. Photocrosslinked PAA modified with HEMA hydrogels that retained a large amount of water, above 85%, were successfully prepared. Based on the analysis of ANOVA, the gel strength and adhesiveness increased with an increase in the degree of modification with HEMA and the concentration of PAA modified with HEMA in the aqueous solution. For the optimization study, the modification with HEMA and the concentration of initiator were selected as causal factors. Gel yield, probe tack, degree of swelling and turbidity were selected as response variables. A set of causal factors and response variables was used as a tutorial date for the prediction of optimal formulation with a quadratic regression model, an artificial neural network (ANN) and a multivariate spline interpolation (MSI). Response surfaces generated with MSI well represented the nonlinear relationship between the factors and the responses, and all the observed values of the response variables coincided with the predictions. A high functional photocrosslinked PAA modified with HEMA hydrogel as an adhesive for a dermatological patch was successfully created using the simultaneous optimization technique incorporating MSI.
authors.affiliation: Department of Pharmaceutics, Hoshi University, Ebara 2-4-41, Shinagawa, Tokyo 142-8501, Japan. onuki@hoshi.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Onuki
authors.forename: Masaru
authors.initials: M
authors.lastname: Hoshi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Okabe
authors.forename: Mikito
authors.initials: M
authors.lastname: Fujikawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Morishita
authors.forename: Kozo
authors.initials: K
authors.lastname: Takayama
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000279:Administration, Cutaneous; D000704:Analysis of Variance; D002626:Chemistry, Pharmaceutical; D003432:Cross-Linking Reagents; D020100:Hydrogels / Q000737:chemistry*; D009391:Nephelometry and Turbidimetry; D010777:Photochemistry; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry*; D012044:Regression Analysis; D014466:Ultraviolet Rays
chemical_list: D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D020100:Hydrogels; D011102:Polyhydroxyethyl Methacrylate; C006903:carbopol 940