[New markers of autoimmunity against joints and salivary glands in HCV infected patients].
OBJECTIVE
In 35 HCV infected patients with arthralgia and myalgia prevalence of anti-fodrin antibodies and anti-flilagrin antibodies was estimated--in comparison with other immunologic markers (ANA, krioglobulinemia, CCI, RF, anti-SSA) and clinical symptoms.


RESULTS
Anti-filagrin antibodies were fund in one case. Anti-fodrin Ab--in two cases. Cryoglobulins, CCI, RF were frequent in estimated group. Many patients had different symptoms simultaneously. In 10 persons without serological markers clinical symptoms were the weakest.


CONCLUSIONS
In HCV infected patients arthralgias have different mechanism than in rheumatoid arthritis--although RF IgM is frequently found. Patients have often cryoglobulinemia and complexemia. Anti-SSA and anti-fodrin antibodies are rare in HCV-infected patients. Sicca syndrome in HCV infection is frequent, but etiology is probably different than in classic Sjögren's syndrome.
Jabłońska
Joanna
J
Klinika Hepatologii i Nabytych Niedoborów Immunologicznych, Instytut Chorób Zakaźnych i Pasozytniczych AM w Warszawie. liver@zigzag.pl
Zabek
Jakub
J
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000503:physiopathology; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D003450:Cryoglobulins / Q000378:metabolism; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007154:Immune System Diseases / Q000821:virology; D008297:Male; D008875:Middle Aged; D011044:Poland; D012217:Rheumatoid Factor / Q000097:blood; D012469:Salivary Glands / Q000276:immunology* / Q000503:physiopathology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015415:Biomarkers; D003450:Cryoglobulins; D012217:Rheumatoid Factor