title: Whole genome linkage scan of recurrent depressive disorder from the depression network study.
abstract: Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.
authors.affiliation: Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK. p.mcguffin@iop.kcl.ac.uk
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
authors.forename: Jo
authors.initials: J
authors.lastname: Knight
authors.forename: Gerome
authors.initials: G
authors.lastname: Breen
authors.forename: Shyama
authors.initials: S
authors.lastname: Brewster
authors.forename: Peter R
authors.initials: PR
authors.lastname: Boyd
authors.forename: Nick
authors.initials: N
authors.lastname: Craddock
authors.forename: Mike
authors.initials: M
authors.lastname: Gill
authors.forename: Ania
authors.initials: A
authors.lastname: Korszun
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Lefkos
authors.initials: L
authors.lastname: Middleton
authors.forename: Ole
authors.initials: O
authors.lastname: Mors
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Julia
authors.initials: J
authors.lastname: Perry
authors.forename: Martin
authors.initials: M
authors.lastname: Preisig
authors.forename: Theodore
authors.initials: T
authors.lastname: Reich
authors.forename: John
authors.initials: J
authors.lastname: Rice
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones
authors.forename: Pak
authors.initials: P
authors.lastname: Sham
authors.forename: Anne E
authors.initials: AE
authors.lastname: Farmer
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002874:Chromosome Mapping; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D012008:Recurrence; D018433:Twin Studies as Topic