[Evaluation of insulin resistance and lipid profile in turner syndrome].
OBJECTIVE
To evaluate the presence of insulin resistance (IR) and changes in lipid profile in Turner Syndrome (TS), and to check the influence of age, karyotype, systemic arterial hypertension (SAH), height, weight, body mass index (BMI), and pubertal development.


METHODS
A transversal study of 35 TS patients, confirmed with karyotype (5 to 43 years), without previous use of anabolic steroid or hGH, with evaluation of blood pressure, pubertal development, anthropometric data, measurement of waist (W), hip (H), W to H ratio, total cholesterol, HDL, triglycerides (TGC), LDL, insulin and glucose. HOMA and QUICKI indexes were calculated, as well as glucose to insulin ratio (G/I). Data were examined by the Mann-Whitney and Spearman tests.


RESULTS
Ten patients were >20 years. Seventeen had a 45,X karyotype and 6 structural aberrations; differences of the variables in relation to the karyotypes were not observed; 15 were nonpubertal and 20 pubertal; TGC and HOMA were significantly higher in puberty, while G/I was lower. Seven had normal height, 8 had BMI >25 Kg/m2 (6 between 25 and 30, and 2 >30), and 19 W/H >0.85. Cholesterol levels were 180 +/- 42mg% (4 >240); HDL 57 +/- 16mg%; LDL 99 +/- 34 mg%; TGC 108 +/- 96 mg% (2 >200); HOMA 1.01 +/- 0.71; QUICKI 0.4 +/- 0.04 and G/I 23.5 +/- 12.1 (2 <7.0).


CONCLUSIONS
Changes were observed in lipid profile independent of age, karyotype, SAH and obesity, but associated with IR. The frequency of IR was lower than described in literature, and seems to be directly linked to chronological age, obesity and estrogen therapy.
de Armani
Maria C A
MC
Laboratório de Crescimento e Composição Corporal, Faculdade de Ciências Médicas, Universidade Estadual de Campinas. gilguer@fcm.unicamp.br
Baldin
Alexandre Duarte
AD
Lemos-Marini
Sofia H V
SH
Baptista
Maria Tereza M
MT
Maciel-Guerra
Andréa T
AT
Guerra-Junior
Gil
G
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D014424:Turner Syndrome / Q000235:genetics / Q000378:metabolism*
D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides