[Prevalence of thyroid autoimmunity in a group of patients with type 1 diabetes mellitus in Londrina, PR].
Thyroid autoimmunity is a frequent comorbid condition subjects with in type 1 diabetes mellitus (DM1). We evaluated the prevalence of antithyroid autoantibodies (antimicrosomal, antithyroglobulin and antithyroid peroxidase), in addition to clinical (gender, age, DM duration) and laboratory (TSH, HbA1) characteristics of 101 patients (mean age 20 +/- 9.6 years; 62 female) followed at the HC/UEL.


RESULTS
Autoantibodies were found in 31 subjects (30.7%). In the age group <12 years, 15% had thyroid antibodies; from 12 to 18 years, 32%, and >18 years, 35.7% (p= 0.22). Among the patients with positive antibodies, 40% had some thyroid dysfunction vs only 4.4% of those without antibodies (p<0.001). The average TSH was higher in the positive than in negative group (3.75 and 2.32microU/mL, respectively; p= 0.01).


CONCLUSIONS
The prevalence of thyroid antibodies was 30.7%, in accordance to the literature.
Souza
Otton Luis Raffo
OL
Disciplina de Endocrinologia, Centro de Ciências da Saúde, Universidade Estadual de Londrina, PR. ottonraffo@hotmail.com
Diehl
Leandro Arthur
LA
Carleto
Lineu Domingos
LD
Garcia
Valdinei
V
Carrilho
Alexandre José F
AJ
de Oliveira
Maria Leocádia
ML
de Almeida
Henriqueta G G
HG
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D001323:Autoantibodies / Q000097:blood*; D001938:Brazil; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000276:immunology; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D001323:Autoantibodies; C006606:anti-thyroglobulin; D010544:Peroxidases