Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice.
In the present study, the effects of water-alcohol extract of Papaver rhoeas on the acquisition and expression of morphine-induced conditioned place preference (CPP) in mice were investigated. Subcutaneous (s.c.) administration of morphine (1, 10 and 20 mg/kg) produced place preference. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. Injection of extract (25, 50 and 100 mg/kg, i.p.) 30 min before the morphine administration decreased the acquisition of morphine CPP. Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP. It could be concluded that Papaver rhoeas reduced the acquisition but not the expression of morphine-induced conditioned place preference.
Sahraei
Hedayat
H
Department of Physiology and Biophysics, and Behavioral Sciences Research Center, School of Medicine, Baqiyatallah (a.s.), University of Medical Sciences, P.O. Box 19395-6558, Tehran, Iran. h.sahraei@bmsu.ac.ir
Fatemi
Sayedeh Maedeh
SM
Pashaei-Rad
Shahrokh
S
Faghih-Monzavi
Zohreh
Z
Salimi
Seyed Hossein
SH
Kamalinegad
Mohammad
M
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007492:Iran; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage; D010207:Papaver; D010936:Plant Extracts / Q000494:pharmacology*
D010936:Plant Extracts; D009020:Morphine