title: Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland.
abstract: In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal Fc receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants.
authors.affiliation: Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, PO Box 2, H-1400 Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Mayer
authors.forename: Márton
authors.initials: M
authors.lastname: Doleschall
authors.forename: Balázs
authors.initials: B
authors.lastname: Bender
authors.forename: János
authors.initials: J
authors.lastname: Bartyik
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Bosze
authors.forename: László V
authors.initials: LV
authors.lastname: Frenyó
authors.forename: Imre
authors.initials: I
authors.lastname: Kacskovics
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001692:Biological Transport; D002417:Cattle; D003126:Colostrum / Q000276:immunology; D004847:Epithelial Cells / Q000737:chemistry; D005260:Female; D015870:Gene Expression; D007074:Immunoglobulin G / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008321:Mammary Glands, Animal / Q000737:chemistry* / Q000254:growth & development; D036801:Parturition; D011247:Pregnancy; D011961:Receptors, Fc / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014018:Tissue Distribution
chemical_list: D007074:Immunoglobulin G; D011961:Receptors, Fc