title: The management of dry skin with topical emollients--recent perspectives.
abstract: Dry skin (xerosis) is a common symptom of a number of chronic skin diseases, such as atopic dermatitis, but can also be caused by environmental factors, such as cold weather and frequent showering. The condition can cause unsightliness of the skin, discomfort, itching, and can have a negative impact on patients' quality of life. This article will cover recent developments in the understanding of xerosis and its management with emollients. The stratum corneum consists of corneocytes and lipid-enriched intercellular bilayers. These are both produced from keratinocytes in a process called epidermal differentiation. Disturbed epidermal differentiation, resulting in the impairment of stratum corneum intercellular lipid bilayers and natural moisturizing factor, is the root cause of xerosis. The constituent ingredients of emollients should, therefore, address the different factors that contribute to dry skin and, most importantly, attempt to restore epidermal differentiation. The use of lipids, physiological lipids, humectants and antipruritics will help to restore the lipid lamellae, improve skin hydration, skin elasticity and prevent itching. The ideal emollient will include these ingredients plus an agent to support epidermal differentiation. Selecting the correct emollient product and using it regularly are vital factors in the management of xerosis.
authors.affiliation: Klinik für Dermatologie, Venerologie und Allergologie, Universitäts-Hautklinik Kiel. eproksch@dermatology.uni-kiel.de
authors.forename: Ehrhardt
authors.initials: E
authors.lastname: Proksch
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Lachapelle
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D004643:Emollients / Q000627:therapeutic use*; D004817:Epidermis / Q000187:drug effects; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy* / Q000209:etiology; D015603:Keratinocytes / Q000187:drug effects; D008051:Lipid Bilayers; D016896:Treatment Outcome
chemical_list: D004643:Emollients; D008051:Lipid Bilayers