title: Human leukocyte antigen class I and II haplotypes and risk of cervical cancer.
abstract: Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n=365) and cytologically normal population controls (n=681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Carreon
authors.forename: M P
authors.initials: MP
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Hildesheim
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.forename: M
authors.initials: M
authors.lastname: Schiffman
authors.forename: R
authors.initials: R
authors.lastname: Herrero
authors.forename: M C
authors.initials: MC
authors.lastname: Bratti
authors.forename: M E
authors.initials: ME
authors.lastname: Sherman
authors.forename: R J
authors.initials: RJ
authors.lastname: Zaino
authors.forename: M
authors.initials: M
authors.lastname: Carrington
authors.forename: S S
authors.initials: SS
authors.lastname: Wang
mesh_terms: D003364:Costa Rica; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes / Q000235:genetics* / Q000276:immunology; D006801:Humans; D027383:Papillomaviridae / Q000276:immunology; D030361:Papillomavirus Infections / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D014481:United States; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000276:immunology / Q000821:virology
chemical_list: D006680:HLA Antigens