title: Inhibitors of the serotonin transporter protein (SERT): the design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots.
abstract: There is a growing demand for compounds with specificity for the serotonin transporter protein (SERT) that can be conjugated to cadmium selenide/zinc sulfide core shell nanocrystals. This letter describes the design and synthesis of two different biotinylated SERT antagonists that can be attached to streptavidin-coated cadmium selenide/zinc sulfide core shell nanocrystals.
authors.affiliation: The Department of Chemistry, Vanderbilt University, Station B, 351822, Nashville, TN 37235-1822, USA.
authors.forename: Ian D
authors.initials: ID
authors.lastname: Tomlinson
authors.forename: John N
authors.initials: JN
authors.lastname: Mason
authors.forename: Randy D
authors.initials: RD
authors.lastname: Blakely
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Rosenthal
mesh_terms: D019921:Biotinylation; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D015394:Molecular Structure; D045663:Quantum Dots; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D007211:Indoles; D008024:Ligands; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; C507190:N-(2-(4-(1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl-5-(2-oxohexahydro-1H-thieno(3,4-d)imidazol-4-yl)pentanamide); C493230:SLC6A4 protein, human