Designing and testing of an effective oil-in-water microemulsion drug delivery system for in vivo application.
The phase behavior of a new psedoternary system of clove oil/Tween 20 has been studied. Several compositions from the single-phase region were selected and their stability toward time, temperature, and electrolytes has been examined. A particular composition(clove oil/Tween 20/water as 5/30/65) was chosen as the drug delivery system from the clear oil-in-water zone of the pseudoternary system. The droplet dimension and the polydispersity state of the particular composition was determined by dynamic light scattering. A bioactive compound quarcetin was encapsulated in the vehicle. The efficacy of the drug in the vehicle was examined against leishmaniasis in hamster models. The hepatotoxicity of the vehicle (o/w microemulsion) with and without the drug quarcetin was examined by estimating serum alkaline phosphatase, glutamate pyruvate transaminase, urea, and creatinine.
Gupta
S
S
Centre for Surface Science, Department of Chemistry, Jadavpur University, Kolkata, India. cssju@yahoo.co.uk
Moulik
S P
SP
Lala
S
S
Basu
M K
MK
Sanyal
S K
SK
Datta
S
S
D000818:Animals; D045783:Clove Oil / Q000008:administration & dosage; D006224:Cricetinae; D016503:Drug Delivery Systems; D004655:Emulsions; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000188:drug therapy; D008647:Mesocricetus; D011136:Polysorbates / Q000008:administration & dosage; D011794:Quercetin / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use
D045783:Clove Oil; D004655:Emulsions; D011136:Polysorbates; D011794:Quercetin