Painful small-fiber neuropathy in Sjogren syndrome.
Of 20 consecutive patients with Sjögren neuropathy, 16 (80%) presented with burning feet and 12 (60%) with non-length-dependent sensory symptoms. Leg and thigh skin biopsies, performed in 13 patients, including 7 with normal electrophysiology, showed either reduced epidermal nerve fiber (ENF) density or abnormal morphology. ENF loss was frequently non length dependent, suggesting that patients with this disorder commonly have a small-fiber sensory neuronopathy rather than a "dying-back" axonopathy.
Chai
J
J
Department of Neurology, University of Rochester, Rochester, NY, USA.
Herrmann
D N
DN
Stanton
M
M
Barbano
R L
RL
Logigian
E L
EL
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001369:Axons / Q000473:pathology; D001706:Biopsy; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000276:immunology; D009437:Neuralgia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D012261:Ribonucleoproteins / Q000276:immunology; D011984:Sensory Receptor Cells / Q000473:pathology* / Q000503:physiopathology; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D012867:Skin / Q000294:innervation* / Q000473:pathology*; D000097585:SS-B Antigen
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; C035356:SS-A antibodies