title: Gadolinium-enhanced MR imaging of epiphyseal and metaphyseal marrow in normal piglets.
abstract: The purpose of this study is to define the appearance of normal epiphyseal and metaphyseal marrow and normal changes of marrow due to fatty conversion on Gadolinium (Gd)-enhanced MR Imaging. Unenhanced and enhanced T1-weighted MR imaging were performed in proximal and distal femoral ends of 8 healthy piglets at the ages of 2, 4, 6 and 8 weeks, respectively. The changes with age in signal intensity and enhancement ratio of the epiphyseal and metaphyseal marrow with age were examined. The correlation of MRI characteristics with histological findings was studied. Our study showed that marrow of the metaphysis and of periphery of the 2nd ossification center were well vascularized hematopoietic marrow and had great enhancements. The enhancement ratio of metaphysis was greater than that of epiphyseal marrow and both enhancement ratios degraded gradually with age. The central regions of the epiphyseal ossification center and of the diaphysis were of fatty marrow and had little enhancement. It is concluded that on Gd-enhanced MR imaging the hematopoietic marrow of metaphysis and of periphery of the 2nd ossification center had greater enhancement than that of fatty marrow of central region of the 2nd ossification center. All of their enhancements decreased gradually with age.
authors.affiliation: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.forename: Renfa
authors.initials: R
authors.lastname: Wang
authors.forename: Jianpin
authors.initials: J
authors.lastname: Qi
authors.forename: Lihua
authors.initials: L
authors.lastname: Tang
mesh_terms: D000818:Animals; D004838:Epiphyses / Q000033:anatomy & histology*; D005269:Femur / Q000033:anatomy & histology / Q000254:growth & development*; D005682:Gadolinium; D006132:Growth Plate / Q000033:anatomy & histology* / Q000098:blood supply / Q000254:growth & development; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D013552:Swine; D013556:Swine, Miniature
chemical_list: D005682:Gadolinium