title: Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis.
abstract: In this study we investigated the effect of rebamipide enema in patients with steroid-resistant and/or dependent ulcerative colitis. Rebamipide enemas were administered twice daily for a 12-week period; this treatment was further continued longer in patients who requested this. Disease activity index as reflecting the clinical condition and endoscopic index with histological grading were determined before and after the treatment period. Nine of 11 (81.8%) patients on 12-week treatment with rebamipide approved and were classified as colitis in remission. Moreover, seven of 11 patients requested long-term medication, the longest medication term being 80 weeks. These results medicated that rebamipide enemas may be effective in patients with steroid-resistant and/or dependent ulcerative colitis.
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Aichi-Gun, Aichi 480-1195, Japan. mmiyata@ aichi-med-u.ac.jp
authors.forename: Mitsuki
authors.initials: M
authors.lastname: Miyata
authors.forename: Kunio
authors.initials: K
authors.lastname: Kasugai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kakumu
authors.forename: Masafumi
authors.initials: M
authors.lastname: Onishi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000328:Adult; D000409:Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology*; D004351:Drug Resistance; D004733:Enema; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D015363:Quinolones / Q000008:administration & dosage* / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones; D000897:Anti-Ulcer Agents; D015363:Quinolones; C052785:rebamipide; D000409:Alanine