[The GIT-PIX protein complex: a hub to ARF and Rac/Cdc42 GTPases].
We recently described that the tumor suppressor factor Scribble anchors the PIX exchange factor for Rac/Cdc42 and the ARF-GAP GIT proteins at the plasma membrane. Because it has been postulated that the GIT-PIX proteins dimerize and tightly self-assemble to form a high molecular weight complex, this nexus may be capable of linking together important signalling molecules to control cytosqueleton polymerization and membrane dynamics. To date, most studies that have tempted to unravel the function of these proteins have found their implication in a great variety of cellular functions (receptor recycling, endo-exocytosis, cell migration, synapse formation...) but have mostly neglected to consider the multimeric organization of this hub. There is no doubt that our comprehension of physiopathological disorders such as cancers will be improved when the nature of the complex pathways integrated by the GIT-PIX nodule will be understood.
Zeniou-Meyer
Maria
M
CNRS UPR-2356, Neurotransmission et sécrétion neuroendocrine, Centre de neurochimie, Strasbourg, France.
Borg
Jean-Paul
JP
Vitale
Nicolas
N
D018797:Cell Cycle Proteins / Q000737:chemistry / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D009369:Neoplasms / Q000503:physiopathology; D064067:Rho Guanine Nucleotide Exchange Factors; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins
C576603:ARHGEF6 protein, human; C576606:ARHGEF7 protein, human; D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D064067:Rho Guanine Nucleotide Exchange Factors; C480591:SCRIB protein, human; D025521:Tumor Suppressor Proteins; D019204:GTP-Binding Proteins