Small molecule macroarray construction via Ugi four-component reactions.
[reaction: see text] We report the construction of small molecule macroarrays via Ugi four-component reactions on planar cellulose supports. Array synthesis was enabled by the development of a high efficiency photocleavable linker system and the strategic use of both water- and microwave-assisted organic reactions.
Lin
Qi
Q
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1322, USA.
O'Neill
Jennifer C
JC
Blackwell
Helen E
HE
D002482:Cellulose / Q000378:metabolism; D002853:Chromatography, Liquid; D003432:Cross-Linking Reagents / Q000737:chemistry; D016208:Databases, Factual; D046228:Microarray Analysis / Q000379:methods*; D015394:Molecular Structure; D013057:Spectrum Analysis
D003432:Cross-Linking Reagents; D002482:Cellulose