Acute myeloid leukemia after intensive immunosuppressive therapy in aplastic anemia.
A 10-year-old boy was admitted with complaints of fever, pallor, fatigue and skin bleeds of 10 days duration and diagnosed as very severe aplastic anemia. He was given intensive immunosuppressive therapy but showed no response to therapy. He later evolved into acute myeloid leukemia. The occurrence of AML is reviewed and possible pathogenesis is discussed.
Naithani
Rahul
R
Department of Pediatrics, Kalawati Saran Childrens Hospital and Department of Pathology, Lady Hardinge Medical College, New Delhi 110 001, India. dr_rahul6@hotmail.com
Chandra
Jagdish
J
Sharma
Sunita
S
D000741:Anemia, Aplastic / Q000175:diagnosis / Q000188:drug therapy*; D000961:Antilymphocyte Serum / Q000009:adverse effects; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine