A novel route to fully substituted 1H-pyrazoles.
A novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products.
Suen
Yat Fan
YF
Department of Chemistry, University of California, Davis, California 95616, USA.
Hope
Håkon
H
Nantz
Michael H
MH
Haddadin
Makhluf J
MJ
Kurth
Mark J
MJ
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*
D004791:Enzyme Inhibitors; D011720:Pyrazoles; D006859:Hydrogen