title: Milk residues and performance of lactating dairy cows administered high doses of monensin.
abstract: Milk residues and performance were evaluated in lactating cows that were fed up to 10 times the recommended dose of monensin. Following an acclimatization period of 14 d, during which cows were fed a standard lactating cow total mixed ration containing 24 ppm monensin, 18 lactating Holstein dairy cows were grouped according to the level of feed intake and then randomly assigned within each group to 1 of 3 challenge rations delivering 72, 144, and 240 ppm monensin. Outcome measurements included individual cow daily feed intakes, daily milk production, body weights, and monensin residues in composite milk samples from each cow. There were no detectable monensin residues (< 0.005 microg/mL) in any of the milk samples collected. Lactating cows receiving a dose of 72 ppm monensin exhibited up to a 20% reduction in dry matter intake, and a 5% to 15% drop in milk production from the pre-challenge period. Cows receiving doses of 144 and 240 ppm monensin exhibited rapid decreases in feed intake of up to 50% by the 2nd d and milk production losses of up to 20% and 30%, respectively, within 4 d. Lactating cows receiving up to 4865 mg monensin per day had no detectable monensin residues (< 0.005 microg/mL) in any of the milk samples collected. Results of this study confirm that food products derived from lactating dairy cattle receiving monensin at recommended levels are safe for human consumption.
authors.affiliation: Elanco, A Division of Eli Lilly Canada Inc, 150 Research Lane, Suite 120, Guelph, Ontario. Bagg_Randy@Lilly.com
authors.forename: Randal
authors.initials: R
authors.lastname: Bagg
authors.forename: Gordon H
authors.initials: GH
authors.lastname: Vessie
authors.forename: C Paul
authors.initials: CP
authors.lastname: Dick
authors.forename: Todd
authors.initials: T
authors.lastname: Duffield
authors.forename: Jeff B
authors.initials: JB
authors.lastname: Wilson
authors.forename: Jeff J
authors.initials: JJ
authors.lastname: Aramini
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism / Q000502:physiology*; D003257:Consumer Product Safety; D004305:Dose-Response Relationship, Drug; D004350:Drug Residues / Q000032:analysis*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D007476:Ionophores / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007774:Lactation / Q000187:drug effects* / Q000502:physiology; D008892:Milk / Q000737:chemistry* / Q000378:metabolism; D008985:Monensin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation
chemical_list: D007476:Ionophores; D008985:Monensin