Viral strategies for evading antiviral cellular immune responses of the host.
The host invariably responds to infecting viruses by activating its innate immune system and mounting virus-specific humoral and cellular immune responses. These responses are aimed at controlling viral replication and eliminating the infecting virus from the host. However, viruses have evolved numerous strategies to counter and evade host's antiviral responses. Providing specific examples from the published literature, we discuss in this review article various strategies that viruses have developed to evade antiviral cellular responses of the host. Unraveling these viral strategies allows a better understanding of the host-pathogen interactions and their coevolution. This knowledge is important for identifying novel molecular targets for developing antiviral reagents. Finally, it may also help devise new knowledge-based strategies for developing antiviral vaccines.
Iannello
Alexandre
A
Ste-Justine Hospital Research Center, Department of Microbiology and Immunology, University of Montreal, Quebec, Canada.
Debbeche
Olfa
O
Martin
Elodie
E
Attalah
Lynda Habiba
LH
Samarani
Suzanne
S
Ahmad
Ali
A
D000818:Animals; D000998:Antiviral Agents / Q000276:immunology / Q000627:therapeutic use; D005075:Biological Evolution; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D014779:Virus Replication / Q000276:immunology*; D014780:Viruses / Q000276:immunology*
D000998:Antiviral Agents; D014765:Viral Vaccines