title: Effect of Aerodiol administration on cerebral blood flow volume in postmenopausal women.
abstract: OBJECTIVE
  The aim of the study was to evaluate the acute effect of the intranasal 17beta-estradiol (Aerodiol, Servier, Chambray-les-Tours, France) administration on cerebral blood flow (CBF) volume.
  
  
  METHODS
  Eighteen healthy women who had been natural postmenopausal for at least 1 year were enrolled in the study. We conducted an experimental, randomized, placebo-controlled, crossover, double-blinded study of the acute effect of 17beta-estradiol on the internal carotid artery (ICA), vertebral artery (VA) and, CBF volume using color duplex sonography.
  
  
  RESULTS
  There were significant increases in the ICA, VA flow volumes and CBF volume after 17beta-estradiol administration compared to placebo measurements. However, there was no statistically significant difference in flow velocities or pulsatility indices.
  
  
  CONCLUSIONS
  Nasal 17beta-estradiol administration in postmenopausal women causes significant increases in CBF volume due to its vasodilatatory effect on ICA and VA.
authors.affiliation: Afyon Kocatepe University Faculty of Medicine, Department of Radiology, Kirmizi Hastane, Turkey. drmacar@hotmail.com
authors.forename: Murat
authors.initials: M
authors.lastname: Acar
authors.forename: Arif Serhan
authors.initials: AS
authors.lastname: Cevrioglu
authors.forename: Alpay
authors.initials: A
authors.lastname: Haktanir
authors.forename: Reha
authors.initials: R
authors.lastname: Demirel
authors.forename: Ramazan
authors.initials: R
authors.lastname: Albayrak
authors.forename: Bumin
authors.initials: B
authors.lastname: Degirmenci
authors.forename: Aylin
authors.initials: A
authors.lastname: Yucel
authors.forename: Ahmet Melih
authors.initials: AM
authors.lastname: Akyol
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D018615:Ultrasonography, Doppler, Color; D017585:Ultrasonography, Doppler, Transcranial; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000187:drug effects
chemical_list: D004958:Estradiol