Nonreductive deiodination of ortho-iodo-hydroxylated arenes using tertiary amines.
A convenient and nonreductive deiodination is reported for the ortho-iodo-hydroxylated arenes including derivatives of quinolinol, phenol, and naphthol. Tertiary amines pyridine, triethylamine, and N-methylmorpholine in the presence of water initiated deiodination of ortho-iodo-hydroxylated arenes without affecting para-iodine and other reduction-susceptible groups. This reported method also works efficiently for polyiodinated systems. Simplicity, short reaction times, and absence of reducing catalyst are features of this method.
Talekar
Rahul Subhash
RS
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Chen
Grace Shiahuy
GS
Lai
Shin-Yu
SY
Chern
Ji-Wang
JW
D000588:Amines / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006900:Hydroxylation; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000588:Amines; D006841:Hydrocarbons, Aromatic; D007455:Iodine