[Normal and malignant choroidal melanocytes: from cell to clinical approach].
The molecular and cellular basis of human choroidal malignant melanoma progression has remained largely unknown. However, choroidal melanoma is the most important primary intraocular tumor in adults. Developmentally, choroidal melanocytes are of neural crest origin similar to cutaneous melanocytes. However, there are some significant differences between cutaneous and uveal melanocytes that have yet to be fully assessed. The purpose of this study is to describe choroidal melanocytes. We will describe the significant differences between cutaneous and uveal melanocytes as well as the congenital and acquired diseases of uveal melanocytes. We will then describe the cellular and molecular mechanisms involved in melanoma progression.
Mouriaux
F
F
Service d'Ophtalmologie, CHU Côte de Nacre, Caen. mouriaux-f@chu-caen.fr
Saule
S
S
Desjardins
L
L
Mascarelli
F
F
D049109:Cell Proliferation; D002829:Choroid / Q000166:cytology* / Q000473:pathology*; D015862:Choroid Diseases / Q000473:pathology*; D002830:Choroid Neoplasms / Q000473:pathology*; D006801:Humans; D008544:Melanocytes / Q000166:cytology* / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*