title: Breakthrough Candida krusei fungemia during fluconazole prophylaxis followed by breakthrough zygomycosis during caspofungin therapy in a patient with severe aplastic anemia who underwent stem cell transplantation.
abstract: We report a case of breakthrough invasive zygomycosis in a stem cell transplant recipient who was receiving caspofungin for treatment of a breakthrough Candida krusei fungemia that occurred during fluconazole prophylaxis. Also, patients receiving the echinocandin caspofungin remain at risk for pathogens, such as zygomycetes, that are intrinsically resistant to this agent.
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Rome 00161, Italy. girmenia@bce.uniroma1.it
authors.forename: Corrado
authors.initials: C
authors.lastname: Girmenia
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Moleti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Micozzi
authors.forename: Anna Paola
authors.initials: AP
authors.lastname: Iori
authors.forename: Walter
authors.initials: W
authors.lastname: Barberi
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
authors.forename: Pietro
authors.initials: P
authors.lastname: Martino
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000145:classification / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D000077336:Caspofungin; D018890:Chemoprevention; D054714:Echinocandins; D017809:Fatal Outcome; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D005658:Fungi; D006801:Humans; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D020096:Zygomycosis / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin