Depot medroxyprogesterone acetate: implications for weight status and bone mineral density in the adolescent female.
Depot medroxyprogesterone acetate (DMPA) is an effective and easy-to-use contraceptive method for adolescents. However, recent literature suggests that overweight teens may be at increased risk for weight gain while on this contraceptive method, and decreases in bone mineral density have been documented in adolescents on DMPA, particularly with longer duration of use. Consideration of this new literature on DMPA and its implications for clinical practice must be done in the context of the United States having the highest adolescent pregnancy rate in the industrialized world. Hence, potential DMPA risks need to be weighed against the risk of unintended pregnancy in an adolescent.
Bonny
Andrea E
AE
Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. abonny@metrohealth.org
Harkness
Laura S
LS
Cromer
Barbara A
BA
D000293:Adolescent; D001823:Body Composition / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000009:adverse effects*; D003431:Cross-Cultural Comparison; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D009765:Obesity / Q000503:physiopathology; D010352:Patient Dropouts; D011247:Pregnancy; D011253:Pregnancy in Adolescence / Q000517:prevention & control* / Q000523:psychology; D012307:Risk Factors; D015430:Weight Gain / Q000187:drug effects* / Q000208:ethnology
D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate