Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides.
An analytical HPLC method using CHIREX (S)-LEU/(S)-alpha-NEA column was developed for the determination of the enantiomeric excesses of N-protected (S)-3-hydroxyglutarimides. Using this method, detailed studies on the base-promoted ring-expansion reaction of the amidolactones, derived from l-glutamic acid, were undertaken.
Ruan
Yuan-Ping
YP
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Fujian, PR China. ypruan@jingxian.xmu.edu.cn
Wei
Bang-Guo
BG
Xu
Xiu-Qing
XQ
Liu
Gang
G
Yu
De-Sheng
DS
Liu
Liang-Xian
LX
Huang
Pei-Qiang
PQ
D002851:Chromatography, High Pressure Liquid; D006900:Hydroxylation; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry*; D013237:Stereoisomerism
D010881:Piperidones; C007864:glutarimide