Chelating diamide based rate enhancement of intramolecular alkene hydroaminations catalyzed by a neutral Sc(III) complex.
[reaction: see text] Neutral scandium amido complexes are viable catalysts for intramolecular alkene hydroamination. Catalytic activity is strongly coupled to the electronic character of the Sc(III) ligand environment with chelating diamide coordination providing a precatalyst possessing substantially improved activity and superb distereoselectivity in the synthesis of trans-2,5-disubstituted pyrrolidines.
Kim
Joon Young
JY
Department of Chemistry, Montana State University, Bozeman, Montana 59717, USA.
Livinghouse
Tom
T
D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D002614:Chelating Agents / Q000737:chemistry*; D003958:Diamide / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D012538:Scandium / Q000737:chemistry*
D000475:Alkenes; D002614:Chelating Agents; D003958:Diamide; D006859:Hydrogen; D012538:Scandium