title: Transcription factors and drug resistance.
abstract: Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of chemotherapy. Anticancer agents are known to modulate signal transduction pathways and alter expression of genes that play an important role in drug resistance. Emerging evidence suggests that the complexity of genomic response against anticancer agents arise from elaborate gene expression by multiple transcription factors. Here, we briefly describe the development of solid tumours and the appearance of drug-resistant cells. We also review what is known of the transcription factors that are involved in resistance to drugs, particularly cisplatin.
authors.affiliation: Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka 807-8555, Japan. k-kohno@med.uoeh-u.ac.jp
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Kohno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uchiumi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Niina
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Wakasugi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Igarashi
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Momii
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Matsuo
authors.forename: Naoya
authors.initials: N
authors.lastname: Miyamoto
authors.forename: Hiroto
authors.initials: H
authors.lastname: Izumi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D004249:DNA Damage / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D014157:Transcription Factors; D002945:Cisplatin