New multiresidue analytical method dedicated to trace level measurement of brominated flame retardants in human biological matrices.
A new method has been developed for the multi-residue measurement of the main brominated flame retardants (alpha- and gamma-hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBP-A) and polybrominated diphenyl ethers including decabromodiphenyl ether) in human biological matrices (serum, adipose tissue and breast milk). The proposed sample preparation procedure focused on reduced solvent and consumable consumption and associated procedural contamination, as well as reduced sample size. This protocol was fully validated and was proved to be suitable for identification of brominated flame retardant residues at ultra-trace level, as attested by preliminary results on real samples.
Cariou
Ronan
R
LABoratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA,) Ecole Nationale Vétérinaire de Nantes, France.
Antignac
Jean-Philippe
JP
Marchand
Philippe
P
Berrebi
Alain
A
Zalko
Daniel
D
Andre
François
F
Le Bizec
Bruno
B
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002417:Cattle; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005411:Flame Retardants / Q000032:analysis*; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000032:analysis*; D008895:Milk, Human / Q000737:chemistry; D010647:Phenyl Ethers / Q000032:analysis; D011075:Polybrominated Biphenyls / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization
D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C089796:hexabromocyclododecane; C086401:pentabromodiphenyl ether; C020806:tetrabromobisphenol A; C010902:decabromobiphenyl ether