title: [A case of complete response after neoadjuvant chemotherapy for advanced esophageal cancer with low-dose FP therapy].
abstract: The patient was a 58-year-old man complaining of vomit and body-weight loss of 10 kg with advanced lower thoraco-abdominal esophageal cancer, which was 9 cm in length and with a maximum diameter of 5.5 cm on thoracic CT examination. Moderately differentiated squamous cell carcinoma diagnosed by pre-operative endoscopic biopsy. Low-dose FP therapy (continuous 5-FU div of 500 mg/day with intermittent CDDP div of 5 mg/day) was performed during 4 weeks as neoadjuvant chemotherapy. The side effect was little, and the tumor size was remarkably reduced. A histological complete response was diagnosed with no carcinoma cells evident in the resected specimen. The patient is alive and healthy with no relapse of the carcinoma 30 months after operation. We are first planning neoadjuvant chemotherapy, and then considering the additional radiotherapy after estimating the effect of chemotherapy. Low-dose FP therapy with low-dose cisplatin as a modulator does not show much side effect and is useful for esophageal cancer. We consider that the chemotherapy is more effective preoperatively than postoperatively because it preserves the feeding vessels for transporting the medicine to the focus of the disease.
authors.affiliation: Dept. of Surgery, Fukushima Rosai Hospital.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Muto
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Tsukada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohtani
authors.forename: Hisahito
authors.initials: H
authors.lastname: Endoh
authors.forename: Kaori
authors.initials: K
authors.lastname: Koyama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satoh
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D016629:Esophagectomy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012074:Remission Induction
chemical_list: D002945:Cisplatin; D005472:Fluorouracil