Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy.
BACKGROUND
Spontaneous pregnancy is rare after radical cytoreduction and intraperitoneal chemotherapy.


METHODS
We present a case of a 28-year-old female with extensive, bulky malignant peritoneal epitheliod mesothelioma who underwent optimal cytoreduction with peritonectomy followed by intraoperative hyperthermic cisplatin and postoperative intraperitoneal paclitaxel and fluorouracil. Fourteen months after the conclusion of her therapy, she spontaneously conceived, resulting in an uneventful term pregnancy and spontaneous vaginal delivery.


CONCLUSIONS
Fertility may be preserved in select patients after radical cytoreduction and hyperthermic intraperitoneal chemotherapy.
Kyser
Kathy
K
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, 6900 Georgia Ave., NW, Washington, DC, 20307, USA.
Bidus
Michael A
MA
Rodriguez
Mildred
M
Rose
G Scott
GS
Elkas
John C
JC
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005298:Fertility; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D008654:Mesothelioma / Q000628:therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011247:Pregnancy
D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil