title: Evaluation of photochemical tissue bonding for closure of skin incisions and excisions.
abstract: OBJECTIVE
  Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions.
  
  
  METHODS
  Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology.
  
  
  RESULTS
  Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks.
  
  
  CONCLUSIONS
  PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kamegaya
authors.forename: William A
authors.initials: WA
authors.lastname: Farinelli
authors.forename: Agustina V
authors.initials: AV
authors.lastname: Vila Echague
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Akita
authors.forename: Jamie
authors.initials: J
authors.lastname: Gallagher
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Flotte
authors.forename: R Rox
authors.initials: RR
authors.lastname: Anderson
authors.forename: Robert W
authors.initials: RW
authors.lastname: Redmond
authors.forename: Irene E
authors.initials: IE
authors.lastname: Kochevar
mesh_terms: D000818:Animals; D062109:Dermatologic Surgical Procedures; D004954:Esthetics; D005456:Fluorescent Dyes / Q000008:administration & dosage*; D028022:Low-Level Light Therapy; D008297:Male; D010777:Photochemistry; D012395:Rose Bengal / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology; D013537:Sutures; D013552:Swine; D013556:Swine, Miniature; D014014:Tissue Adhesives; D014945:Wound Healing
chemical_list: D005456:Fluorescent Dyes; D014014:Tissue Adhesives; D012395:Rose Bengal