[Lung protection of continuous pulmonary artery perfusion with oxygenated blood during cardiopulmonary bypass].
OBJECTIVE
To determine the lung protection of continuous pulmonary artery perfusion with oxygenated blood during cardiopulmonary bypass (CPB).


METHODS
Thirty patients undergoing mitral valve replacement were randomly divided into the control group (n=15) and the lung perfusion group (n=15). The patients in the lung perfusion group were perfused oxygenated blood continuously to the pulmonary artery during CPB. The patients in the control group were performed the routine procedure of mitral valve replacement. Record the CPB time, aortic cross-clamp time, mechanical ventilation time and ICU monitoring time. The patients' oxygen index (OI) and lung static compliance (Cstat) were measured before the surgery, at 0 h after the CPB and at 0, 6 h after the surgery. Right lung biopsy specimens were obtained at 30 min after the CPB to observe the histological changes. Results The mechanical ventilation time and ICU monitoring time were shorter in the lung perfusion group than those in the control group (P < 0.05). The patients' OI and Cstat were higher after surgery in the lung perfusion group than those in the control group (P < 0.05). Tissue examination showed lung parenchyma edema and inflammatory cells accumulated in the control group, while no remarkable pathological changes occurred in the lung perfusion group.


CONCLUSIONS
Lung injury exists after the surgery by CPB. Continuous pulmonary artery perfusion with oxygenated blood during CPB can decrease the lung injury.
Liu
Li-ming
LM
Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. Liulimingjia@yahoo.com.cn
Hu
Jian-guo
JG
Yin
Bang-liang
BL
Yang
Yi-feng
YF
Zhang
Wei
W
Yi
Ding-wu
DW
Liu
Shao-qun
SQ
D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D010477:Perfusion / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D011651:Pulmonary Artery; D011652:Pulmonary Circulation; D015427:Reperfusion Injury / Q000517:prevention & control*
D010100:Oxygen