Magnetic resonance imaging for detection and analysis of mouse phenotypes.
With the enormous and growing number of experimental and genetic mouse models of human disease, there is a need for efficient means of characterizing abnormalities in mouse anatomy and physiology. Adaptation of magnetic resonance imaging (MRI) to the scale of the mouse promises to address this challenge and make major contributions to biomedical research by non-invasive assessment in the mouse. MRI is already emerging as an enabling technology providing informative and meaningful measures in a range of mouse models. In this review, recent progress in both in vivo and post mortem imaging is reported. Challenges unique to mouse MRI are also identified. In particular, the needs for high-throughput imaging and comparative anatomical analyses in large biological studies are described and current efforts at handling these issues are presented.
Nieman
Brian J
BJ
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada. brian.nieman@sw.ca
Bock
Nicholas A
NA
Bishop
Jonathon
J
Chen
X Josette
XJ
Sled
John G
JG
Rossant
Janet
J
Henkelman
R Mark
RM
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D004195:Disease Models, Animal; D004558:Electric Stimulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D051379:Mice / Q000033:anatomy & histology / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D010641:Phenotype