title: Rapamycin analogs with reduced systemic exposure.
abstract: The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.
authors.affiliation: Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. rolf.wagner@abbott.com
authors.forename: Rolf
authors.initials: R
authors.lastname: Wagner
authors.forename: Karl W
authors.initials: KW
authors.lastname: Mollison
authors.forename: Luping
authors.initials: L
authors.lastname: Liu
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Henry
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Rosenberg
authors.forename: Nwe
authors.initials: N
authors.lastname: Bamaung
authors.forename: Noah
authors.initials: N
authors.lastname: Tu
authors.forename: Paul E
authors.initials: PE
authors.lastname: Wiedeman
authors.forename: Yatsun
authors.initials: Y
authors.lastname: Or
authors.forename: Jay R
authors.initials: JR
authors.lastname: Luly
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Lane
authors.forename: James
authors.initials: J
authors.lastname: Trevillyan
authors.forename: Yung-Wu
authors.initials: YW
authors.lastname: Chen
authors.forename: Thomas
authors.initials: T
authors.lastname: Fey
authors.forename: Gin
authors.initials: G
authors.lastname: Hsieh
authors.forename: Kennan
authors.initials: K
authors.lastname: Marsh
authors.forename: Merrill
authors.initials: M
authors.lastname: Nuss
authors.forename: Peer B
authors.initials: PB
authors.lastname: Jacobson
authors.forename: Denise
authors.initials: D
authors.lastname: Wilcox
authors.forename: Richard P
authors.initials: RP
authors.lastname: Carlson
authors.forename: George W
authors.initials: GW
authors.lastname: Carter
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000633:toxicity; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D011859:Radiography; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D020123:Sirolimus / Q000031:analogs & derivatives*
chemical_list: D018501:Antirheumatic Agents; D020123:Sirolimus