title: Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion.
abstract: Short-term selective breeding created mouse lines divergent for ethanol drinking (high drinking short-term selected line [STDRHI], low drinking [STDRLO]) or ethanol-induced conditioned taste aversion (CTA; high [HTA], low [LTA]). Compared with STDRLO, STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned place preference (CPP), and showed reduced ethanol stimulation and sensitization under some conditions; a line difference in ethanol-induced CTA was not consistently found. Compared with LTA, HTA mice consumed less ethanol but were similar in saccharin consumption, sensitivity to ethanol-induced CPP, and ethanol-induced locomotor stimulation and sensitization. These data suggest that ethanol drinking is genetically associated with several reward-and aversion-related traits. The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2.
authors.affiliation: Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239, USA. phillipt@ohsu.edu
authors.forename: Tamara J
authors.initials: TJ
authors.lastname: Phillips
authors.forename: Julie
authors.initials: J
authors.lastname: Broadbent
authors.forename: Sue
authors.initials: S
authors.lastname: Burkhart-Kasch
authors.forename: Carly
authors.initials: C
authors.lastname: Henderson
authors.forename: Charlotte D
authors.initials: CD
authors.lastname: Wenger
authors.forename: Carrie
authors.initials: C
authors.lastname: McMullin
authors.forename: Carrie S
authors.initials: CS
authors.lastname: McKinnon
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Cunningham
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics*; D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001522:Behavior, Animal; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010641:Phenotype; D011803:Quinine / Q000008:administration & dosage; D012201:Reward; D012439:Saccharin / Q000008:administration & dosage; D012641:Selection, Genetic; D012737:Sex Factors; D013223:Statistics as Topic; D013549:Sweetening Agents / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D002492:Central Nervous System Depressants; D013549:Sweetening Agents; D000431:Ethanol; D011803:Quinine; D012439:Saccharin