title: Essential oil composition, antibacterial and antioxidant activity of the oil and various extracts of Ziziphora clinopodioides subsp. rigida (BOISS.) RECH. f. from Iran.
abstract: The chemical composition of the essential oil obtained from the aerial parts of Z. clinopodioides subsp. rigida (BOISS.) RECH. f. was analysed by GC and GC-MS. Thirty-one constituents accounting to 99.5% of the total oil were identified. Oxygenated monoterpenes (93.3%) were the predominant portion of the oil with pulegone (45.8%), piperitenone (17.4%), p-menth-3-en-8-ol (12.5%) and thymol (8.0%) as the main constituents. Antibacterial activity of the oil and its two main compounds and various extracts of plant were tested against seven Gram-(+) or Gram-(-) bacteria. It was found that the oil and MeOH extract (M) exhibited interesting antibacterial activity. The samples were also subjected to screening for their possible antioxidant activity by using 2,2-diphenyl-1-picrazylhydrazyl (DPPH) assay. The free radical scavenging activity of MeOH extract (M) was superior to all other extracts (IC50=30.7 microg/ml), while the oil was less effective.
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University; Tehran, Iran. p-salehi@cc.sbu.ac.ir
authors.forename: Peyman
authors.initials: P
authors.lastname: Salehi
authors.forename: Ali
authors.initials: A
authors.lastname: Sonboli
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Eftekhar
authors.forename: Samad
authors.initials: S
authors.lastname: Nejad-Ebrahimi
authors.forename: Morteza
authors.initials: M
authors.lastname: Yousefzadi
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry*; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D009822:Oils, Volatile