title: The prevalence of prostate carcinoma and its precursor in Hungary: an autopsy study.
abstract: OBJECTIVE
  The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries.
  
  
  METHODS
  Autopsy cases (n=139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas.
  
  
  RESULTS
  We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively.
  
  
  CONCLUSIONS
  Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.
authors.affiliation: Department of Pathology, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary.
authors.forename: Gyorgyike
authors.initials: G
authors.lastname: Soos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tsakiris
authors.forename: Janos
authors.initials: J
authors.lastname: Szanto
authors.forename: Csaba
authors.initials: C
authors.lastname: Turzo
authors.forename: P Gabriel
authors.initials: PG
authors.lastname: Haas
authors.forename: Balazs
authors.initials: B
authors.lastname: Dezso
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D005060:Europe / Q000453:epidemiology; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D019048:Prostatic Intraepithelial Neoplasia / Q000453:epidemiology* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000473:pathology; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology