[Calcium channel antagonists and arrhythmias].
Ca channel antagonists (CCA) including verapamil and diltiazem work as antiarrhythmic drugs. Because CCA suppresses conduction through atrio-ventricular (AV) node, it is effective on both AV reciprocating tachycardia (AVRT) and AV nodal reentrant tachycardia (AVNRT). It is also useful to reduce ventricular response during atrial fibrillation/flutter. Idiopathic left ventricular tachycardia (VT) with a right bundle-branch block configuration and superior axis is sensitive to verapamil, and thus called as verapamil-sensitive VT. A caution should be needed to prevent adverse effects based on cardio-depressive effects of CCA.
Takahashi
Naohiko
N
Department of Internal Medicine I, Faculty of Medicine, Oita University.
Saikawa
Tetsunori
T
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006801:Humans
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers