title: [Establishment of a novel arrhythmia model in rats].
abstract: OBJECTIVE
  To establish a novel arrhythmia model in rats.
  
  
  METHODS
  Coronary artery occlusion was produced in hyperlipidemic rats after the animals were fed a high fat and cholesterol chow for 15 days. The incidence, duration and score of arrhythmias were determined 1 hour after coronary occlusion.
  
  
  RESULTS
  The incidence, duration and score of arrhythmia induced by coronary artery occlusion increased significantly in hyperlipidemic rats compared with those in normal rats (P < 0.05). In normal rats, pretreatment with amiodarone 60 mg x kg(-1) or verapamil 25 mg x kg(-1) 3 days before coronary artery occlusion did not influence the incidence, duration and score of arrhythmia (P > 0.05). In hyperlipidemic rats, amiodarone 60 mg x kg(-1) decreased the incidence, duration and score of arrhythmia (P < 0.05), but not verapamil 25 mg x kg(-1) (P > 0.05).
  
  
  CONCLUSIONS
  The novel arrhythmia model induced by coronary artery occlusion in hyperlipidemic rats is reliable and similar to the pathophysiological state in human being.
authors.affiliation: Department of Pharmacology, Harbin Medical University, Bio-pharmaceutical Key Laboratory of Heilongjiang Province, China.
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Pan
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wang
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Du
authors.forename: Jun-Dong
authors.initials: JD
authors.lastname: Jiao
authors.forename: De-Li
authors.initials: DL
authors.lastname: Dong
authors.forename: Bao-Feng
authors.initials: BF
authors.lastname: Yang
mesh_terms: D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications*; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000150:complications*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone