Fetal and neonatal consequences of antenatal exposure to type 1 angiotensin II receptor-antagonists.
Sartans are selective type 1 angiotensin II receptor-antagonists that are used in the treatment of arterial hypertension. Few reports are available concerning the use of sartans during pregnancy. We report two cases of adverse fetal outcome in hypertensive pregnancies exposed to sartans. In the first case, anamnios and fetal renal failure due to severe tubular dysgenesia led to termination of pregnancy in the 27th week. The second patient presented with hypocalvaria and developed fetal renal failure. The use of sartans during the two last trimesters of pregnancy should be strictly avoided.
Vendemmia
Maria
M
Department of Neonatology, Hôpital de la Timone-Enfants, Marseille, France.
Garcia-Méric
Patricia
P
Rizzotti
Alina
A
Boubred
Farid
F
Lacroze
Valérie
V
Liprandi
Agnès
A
Simeoni
Umberto
U
D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011859:Radiography
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II