title: Persistent production of neurons from adult brain stem cells during recovery after stroke.
abstract: Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblasts formed early or late after stroke either differentiate into mature neurons, which survive for several months, or die through caspase-mediated apoptosis. The directed migration of the new neurons toward the ischemic damage is regulated by stromal cell-derived factor-1alpha and its receptor CXCR4. These results show that endogenous neural stem cells continuously supply the injured adult brain with new neurons, which suggests novel self-repair strategies to improve recovery after stroke.
authors.affiliation: Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden.
authors.forename: Pär
authors.initials: P
authors.lastname: Thored
authors.forename: Andreas
authors.initials: A
authors.lastname: Arvidsson
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cacci
authors.forename: Henrik
authors.initials: H
authors.lastname: Ahlenius
authors.forename: Therése
authors.initials: T
authors.lastname: Kallur
authors.forename: Vladimer
authors.initials: V
authors.lastname: Darsalia
authors.forename: Christine T
authors.initials: CT
authors.lastname: Ekdahl
authors.forename: Zaal
authors.initials: Z
authors.lastname: Kokaia
authors.forename: Olle
authors.initials: O
authors.lastname: Lindvall
mesh_terms: D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D002454:Cell Differentiation; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D019718:Receptors, CXCR4 / Q000378:metabolism; D020127:Recovery of Function; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D020521:Stroke / Q000378:metabolism* / Q000473:pathology
chemical_list: D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C486264:Cxcr4 protein, rat; D019718:Receptors, CXCR4; D020169:Caspases