Domain definition and target classification for CASP6.
Assessment of structure predictions in CASP6 was based on single domains isolated from experimentally determined structures, which were categorized into comparative modeling, fold recognition, and new fold targets. Domain definitions were defined upon visual examination of the structures with the aid of automated domain-parsing programs. Domain categorization was determined by comparison of the target structures with those in the Protein Data Bank at the time each target expired and a variety of sequence and structure-based methods to determine potential homologous relationships.
Tress
Michael
M
Protein Design Group, CNB-CSIC, Calle Darwin, 28049 Cantoblanco, Spain.
Tai
Chin-Hsien
CH
Molecular Modeling and Bioformatics Section, Laboratory of Molecular Modeling, Center for Cancer Research, National Institute of Health, Bethesda, Maryland.
Wang
Guoli
G
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Ezkurdia
Iakes
I
Protein Design Group, CNB-CSIC, Calle Darwin, 28049 Cantoblanco, Spain.
López
Gonzalo
G
Protein Design Group, CNB-CSIC, Calle Darwin, 28049 Cantoblanco, Spain.
Valencia
Alfonso
A
Protein Design Group, CNB-CSIC, Calle Darwin, 28049 Cantoblanco, Spain.
Lee
Byungkook
B
Molecular Modeling and Bioformatics Section, Laboratory of Molecular Modeling, Center for Cancer Research, National Institute of Health, Bethesda, Maryland.
Dunbrack
Roland L
RL
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
D000595:Amino Acid Sequence; D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000592:standards; D030562:Databases, Protein; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D040901:Proteomics / Q000379:methods* / Q000592:standards; D017386:Sequence Homology, Amino Acid
D011506:Proteins