title: Repetitive transcranial magnetic stimulation as add-on antidepressant treatment. The applicability of the method in a clinical setting.
abstract: Recent research indicates that repetitive transcranial magnetic stimulation (rTMS) over the frontal cortex has an antidepressant effect. The aim of the present pilot study was to assess the antidepressant effect, side-effects and the applicability in daily clinical practice of left prefrontal high-frequency rTMS. Fifteen inpatients with major depression (ICD-10 and DSM-IV) were randomized to receive 15 days of real left prefrontal high-frequency rTMS (20 trains of 10 s, 60-s interval, 10 Hz, 90% of motor threshold) or sham rTMS as add on to conventional antidepressant treatment. Depressive symptoms and side-effects were evaluated blindly during the treatment period. Five out of eight patients receiving real rTMS suffered from local discomfort during treatment. Three of them dropped out and the project was closed for that reason. Real rTMS did not add efficacy to standard antidepressant medication. This pilot study did not confirm the antidepressant effect of left frontal high-frequency rTMS. Unwanted effects led to considerable patient drop-out and premature termination of the study. The result suggests that alternative treatment delivery technology should be considered.
authors.affiliation: Department N and Mood Disorders Research Unit, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Risskov, Denmark. peh@psykiatri.aaa.dk
authors.forename: Poul Erik Buchholtz
authors.initials: PE
authors.lastname: Hansen
authors.forename: Poul
authors.initials: P
authors.lastname: Videbech
authors.forename: Karin
authors.initials: K
authors.lastname: Clemmensen
authors.forename: Runa
authors.initials: R
authors.lastname: Sturlason
authors.forename: Hans Mørch
authors.initials: HM
authors.lastname: Jensen
authors.forename: Per
authors.initials: P
authors.lastname: Vestergaard
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D012886:Skull; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation*
chemical_list: D000928:Antidepressive Agents