title: Androgens and bone growth: it's location, location, location.
abstract: Androgens increase bone mass in specific skeletal compartments through effects on bone cells, enhancing osteoblast activity but inhibiting that of osteoclasts. The mechanism of action of androgens might involve both classic androgen receptor transcriptional activation and rapid non-genomic effects, and could also be dependent upon low levels of estrogen.
authors.affiliation: Research Service P3 R&D39, VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239-2964, USA. wirenk@ohsu.edu
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Wiren
mesh_terms: D000728:Androgens / Q000502:physiology* / Q000627:therapeutic use; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D011944:Receptors, Androgen / Q000502:physiology; D012727:Sex Characteristics
chemical_list: D000728:Androgens; D011944:Receptors, Androgen