title: Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study.
abstract: Oral appliances have been a popular treatment option for subjects with obstructive sleep apnea. However, little information is available on how brain activation induced by respiratory challenge is modulated by mandibular advancement with these appliances. We hypothesized that the brain activation caused by respiratory stress may be alleviated by mandibular advancement. Respiratory stress was induced in 12 healthy subjects by resistive inspiratory loading. The effects of mandibular advancement during resistive inspiratory loading were assessed subjectively by using a visual analog scale. These effects were also evaluated objectively by using blood oxygenation level-dependent functional magnetic resonance imaging. The score for the visual analog scale significantly decreased with mandibular advancement. Cortical deactivation, in association with mandibular advancement, was localized to several specific regions, including the left cingulate gyrus and the bilateral prefrontal cortexes. These regions are known to be involved in respiratory control. Our results suggest that mandibular advancement with an oral appliance appears to be useful for reducing respiratory stress, based on both subjective and neuronal criteria.
authors.affiliation: Maxillofacial Orthognathics, Graduate School, Tokyo Medical and Dental Univ. 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Ono
authors.forename: Ei-ichi
authors.initials: E
authors.lastname: Honda
authors.forename: Keiko
authors.initials: K
authors.lastname: Maeda
authors.forename: Hideo
authors.initials: H
authors.lastname: Shinagawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Tsuiki
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Hiyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Kurabayashi
authors.forename: Kimie
authors.initials: K
authors.lastname: Ohyama
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004417:Dyspnea / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D001239:Inhalation / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D019186:Mandibular Advancement / Q000295:instrumentation; D010100:Oxygen / Q000097:blood; D010147:Pain Measurement; D017397:Prefrontal Cortex / Q000502:physiology; D012125:Respiratory Center / Q000502:physiology
chemical_list: D010100:Oxygen