title: New multiresidue analytical method dedicated to trace level measurement of brominated flame retardants in human biological matrices.
abstract: A new method has been developed for the multi-residue measurement of the main brominated flame retardants (alpha- and gamma-hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBP-A) and polybrominated diphenyl ethers including decabromodiphenyl ether) in human biological matrices (serum, adipose tissue and breast milk). The proposed sample preparation procedure focused on reduced solvent and consumable consumption and associated procedural contamination, as well as reduced sample size. This protocol was fully validated and was proved to be suitable for identification of brominated flame retardant residues at ultra-trace level, as attested by preliminary results on real samples.
authors.affiliation: LABoratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA,) Ecole Nationale Vétérinaire de Nantes, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Cariou
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Antignac
authors.forename: Philippe
authors.initials: P
authors.lastname: Marchand
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.forename: Daniel
authors.initials: D
authors.lastname: Zalko
authors.forename: François
authors.initials: F
authors.lastname: Andre
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Bizec
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D002417:Cattle; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005411:Flame Retardants / Q000032:analysis*; D055768:Halogenated Diphenyl Ethers; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000032:analysis*; D008895:Milk, Human / Q000737:chemistry; D010647:Phenyl Ethers / Q000032:analysis; D011075:Polybrominated Biphenyls / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D006842:Hydrocarbons, Brominated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; C089796:hexabromocyclododecane; C086401:pentabromodiphenyl ether; C020806:tetrabromobisphenol A; C010902:decabromobiphenyl ether