title: Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus.
abstract: We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters.
authors.affiliation: Clinical Sciences Building, Hope Hospital, Salford, UK.
authors.forename: Derek
authors.initials: D
authors.lastname: Paisley
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Robson
authors.forename: David W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D001232:Aspergillus fumigatus / Q000145:classification / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity*; D048708:Cell Growth Processes / Q000502:physiology*; D051379:Mice; D014774:Virulence