Phagocytosis: the convoluted way from nutrition to adaptive immunity.
Phagocytosis, the process by which cells internalize large particulate materials from their milieu and sequester them in phagosomes, plays a role in a variety of cell functions ranging from nutrition in ameba to innate and adaptive immunity in mammals. Recent findings revealed unexpected characteristics of phagosomes, highlighting how this complex organelle may have evolved, from Dictyostelium to human, to become a key player in our ability to mount an efficient immune response against a variety of intracellular pathogens.
Desjardins
Michel
M
Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montréal, Quebec, Canada. michel.desjardins@umontreal.ca
Houde
Mathieu
M
Gagnon
Etienne
E
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D045142:Cross-Priming / Q000276:immunology; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009747:Nutritional Physiological Phenomena; D010587:Phagocytosis / Q000502:physiology*; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism