title: Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists.
abstract: Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. anandan.palani@spcorp.com
authors.forename: Anandan
authors.initials: A
authors.lastname: Palani
authors.forename: Sherry
authors.initials: S
authors.lastname: Shapiro
authors.forename: Mark D
authors.initials: MD
authors.lastname: McBriar
authors.forename: John W
authors.initials: JW
authors.lastname: Clader
authors.forename: William J
authors.initials: WJ
authors.lastname: Greenlee
authors.forename: Kim
authors.initials: K
authors.lastname: O'Neill
authors.forename: Brian
authors.initials: B
authors.lastname: Hawes
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry
chemical_list: D000577:Amides; C103263:MCHR1 protein, human; D017481:Receptors, Somatostatin; D014508:Urea