title: [Portal vein thrombosis in patients with thrombophilia--own observations].
abstract: Portal vein thrombosis is one of the main prehepatic causes of portal hypertension. The most frequent causes of thrombosis in this localization, apart from hepatic cirrhosis, are the following: acute inflammatory diseases and abdominal cancers, traumas, proliferative diseases of the hematopoietic system. In recent years attention was given to disorders in hemostasis, such as thrombophilia, in the course of which thrombosis development is particularly common. The authors present 10 patients after an incident of portal vein thrombosis, in which primary hepatic pathology was excluded and tests directed at thrombophilia were performed. In seven patients abnormalities in the examined parameters were found, and what is more, in two cases they had a complex character and involved more than one parameter. In five patients hyperhomocysteinemia was found. Among them, in two patients there was also a decreased protein S activity and in one of them there was also APC-resistance. In the next two patients there were abnormalities in one of the examined parameters - APC-resistance. Hyperhomocysteinemia was found in all patients with idiopathic thrombosis, and in one of them there were concurrent changes in protein S activity and APC-resistance. In patients with the history of portal vein thrombosis diagnostics of thrombophilia should be performed.
authors.affiliation: Klinika Chorób Wewnetrznych, Endokrynologii i Zaburzeń Hemostazy Instytutu Chorób Wewnetrznych AM w Gdańsk. rensto@amg.gda.pl
authors.forename: Renata
authors.initials: R
authors.lastname: Swiatkowska-Stodulska
authors.forename: Ewa
authors.initials: E
authors.lastname: Kazimierska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Weyer-Hepka
authors.forename: Dorota
authors.initials: D
authors.lastname: Dworakowska
authors.forename: Monika
authors.initials: M
authors.lastname: Lubińska
authors.forename: Maria
authors.initials: M
authors.lastname: Gnacińska
authors.forename: Alicja
authors.initials: A
authors.lastname: Bakowska
authors.forename: Eugenia
authors.initials: E
authors.lastname: Czestochowska
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology*; D011795:Surveys and Questionnaires; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis*; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology*