title: Clinical inquiries. What treatments prevent miscarriage after recurrent pregnancy loss?
abstract: Progesterone produces a small but significant decrease in miscarriage among pregnant women with 3 or more unexplained pregnancy losses (strength of recommendation [SOR]: A, based on a meta-analysis of 3 small randomized controlled trials [RCTs] with wide confidence intervals). Human chorionic gonadotropin (HCG) reduces the rate of recurrent pregnancy loss among women with 2 or more unexplained pregnancy losses (SOR: B, based on a meta-analysis of 4 RCTs with significant methodologic weaknesses). Four types of immunotherapy are ineffective for preventing miscarriage (SOR: A, based on RCTs and systematic reviews of RCTs). Aspirin therapy is ineffective for preventing recurrent miscarriage for women who do not have an autoimmune explanation for previous pregnancy losses (SOR: A, based on RCTs).
authors.affiliation: Valley Medical Center Family Medicine Residency, Renton, WA USA.
authors.forename: Matt
authors.initials: M
authors.lastname: Price
authors.forename: Gary
authors.initials: G
authors.lastname: Kelsberg
authors.forename: Sarah
authors.initials: S
authors.lastname: Safranek
authors.forename: Beth
authors.initials: B
authors.lastname: Damitz
mesh_terms: D000026:Abortion, Habitual / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000627:therapeutic use*; D055502:Secondary Prevention
chemical_list: D011374:Progesterone