Palladium-catalyzed allylation of acidic and less nucleophilic anilines using allylic alcohols directly.
The direct activation of C-O bonds in allylic alcohols by palladium complexes has been accelerated by carrying out the reactions in the presence of titanium(IV) isoproxide and 4 A molecular sieves. The acidic and less nucleophilic anilines such as diphenylamine, phenothiazine, 4-cyanoaniline, and nitroanilines are efficiently allylated under palladium catalysis using allylic alcohols as allylating reagents.
Hsu
Yi-Chun
YC
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Taiwan, ROC.
Gan
Kim-Hong
KH
Yang
Shyh-Chyun
SC
D000438:Alcohols / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D000814:Aniline Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds; D010165:Palladium / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry
D000438:Alcohols; D000498:Allyl Compounds; D000814:Aniline Compounds; D009942:Organometallic Compounds; D010165:Palladium; C102815:titanium isopropoxide; D014025:Titanium