[Stefin A--potential application in oncological laboratory diagnosis].
This is a review of studies on stefin A, an intracellular cysteine peptidase inhibitor of cystatin superfamily. Cystatins and target cysteine peptidases, such as cathepsins B and L have been implicated in malignant progression. The biochemical characteristics of human stefin A and its functions are presented. Special attention was paid to the potential usefulness of stefin A determination in serum and tissue cytosol (ELISA test) or tissue sections (immunohistochemistry) in the oncological laboratory diagnosis.
Warwas
Maria
M
Katedra i Zakład Biochemii Farmaceutycznej Akademii Medycznej we Wrocławiu. warwas@bf.uni.wroc.pl
D055312:Cystatin A; D015891:Cystatins / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007150:Immunohistochemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D055312:Cystatin A; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors