[Beta3-adrenergic receptor].
The beta3-adrenergic receptor (beta3-AR) may play a key role in the regulation of lipid metabolism and glucose homeostasis. Adrenaline and noradrenaline beta3-AR stimulate lipolysis and thermogenesis in human fat cells and increase glucose uptake in skeletal muscle. Therefore, the beta3-AR gene may be associated with obesity and related diseases, such as type 2 diabetes, coronary heart disease and hypertension. Many studies in different ethnic groups showed an association of beta3-AR gene polymorphism with insulin resistance, obesity and its metabolic disorders such as type 2 diabetes, coronary heart disease and hypertension. A Trp64Arg mutation in the beta3-AR gene has been reported to be correlated with the occurrence of those disorders among obese. Several studies revealed also the influence of the Trp/Arg polymorphism on carcinogenesis and its contribution to the link between cancer and obesity. Since obesity is a serious problem as a civilization-related disease, it is very important to investigate genes suspected to be connected with it.
Babol
Katarzyna
K
Department of Molecular Genetics, University of Lodz, 12/16 Banacha St., 90-237 Lodz, Poland.
Błasiak
Janusz
J
D001786:Blood Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D008066:Lipolysis; D009765:Obesity / Q000150:complications* / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics / Q000378:metabolism*
D001786:Blood Glucose; D022702:Receptors, Adrenergic, beta-3