Gas chromatography/mass spectrometric analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids for verification of the Chemical Weapons Convention.
This paper describes the synthesis and gas chromatography/electron ionization mass spectrometric (GC/EI-MS) analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids (DAESAs). These sulfonic acids are important environmental signatures of nerve agent VX and its toxic analogues, hence GC/EI-MS analysis of their methyl esters is of paramount importance for verification of the Chemical Weapons Convention. DAESAs were prepared by condensation of 2-bromoethane sulfonic acid with dialkylamines, and by condensation of dialkylaminoethyl chloride with sodium bisulfite. GC/EI-MS analysis of methyl esters of DAESAs yielded mass spectra; based on these spectra, generalized fragmentation routes are proposed that rationalize most of the characteristic ions.
Pardasani
Deepak
D
Vertox Laboratory, Defence Research and Development Establishment, Gwalior, India.
Gupta
Arvinda K
AK
Palit
Meehir
M
Shakya
Purushottam
P
Kanaujia
Pankaj K
PK
Sekhar
K
K
Dubey
Devendra K
DK
D017738:Alkanesulfonic Acids / Q000032:analysis* / Q000138:chemical synthesis; D002618:Chemical Warfare; D002619:Chemical Warfare Agents / Q000032:analysis* / Q000138:chemical synthesis; D004784:Environmental Monitoring / Q000379:methods; D004952:Esters; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008745:Methylation; D009946:Organothiophosphorus Compounds / Q000737:chemistry
D017738:Alkanesulfonic Acids; D002619:Chemical Warfare Agents; D004952:Esters; D009946:Organothiophosphorus Compounds; C009680:VX-agent