Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases.
Pyrimido-oxazepine based sub-micromolar inhibitors (2-4) for Aurora and FLT-3 were designed and synthesized. These preliminary results supported the potential use of pyrimido-oxazepines as a versatile template for developing specific kinase inhibitors.
Pan
Weitao
W
Department of Chemistry, ImClone Systems Incorporated, 710 Parkside Avenue, Brooklyn, NY 11226, USA.
Liu
Hu
H
Xu
Yong-Jiang
YJ
Chen
Xin
X
Kim
Ki Hwan
KH
Milligan
Daniel L
DL
Columbus
John
J
Hadari
Yaron R
YR
Kussie
Paul
P
Wong
Wai C
WC
Labelle
Marc
M
D064127:Aurora Kinases; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D010077:Oxazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D010077:Oxazepines; D011743:Pyrimidines; D010770:Phosphotransferases; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases