Molecular pathology of well-differentiated thyroid carcinomas.
The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: "Follicular carcinoma", "Papillary carcinoma", "Follicular variant of papillary carcinoma" and "Hürthle cell tumours". A particular emphasis is put on the meaning of PAX8-PPARgamma rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of nuclear genes encoding for mitochondrial enzymes, for thyroid tumorigenesis.
Sobrinho-Simões
Manuel
M
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), R. Roberto Frias s/n, 4200, Porto, Portugal. ssimoes@ipatimup.pt
Preto
Ana
A
Rocha
Ana Sofia
AS
Castro
Patrícia
P
Máximo
Valdemar
V
Fonseca
Elsa
E
Soares
Paula
P
D018249:Adenoma, Oxyphilic / Q000235:genetics* / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000235:genetics* / Q000473:pathology; D015321:Gene Rearrangement; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D000072636:PAX8 Transcription Factor; D047495:PPAR gamma / Q000235:genetics; D051761:Paired Box Transcription Factors / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D013964:Thyroid Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology
D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D047495:PPAR gamma; D051761:Paired Box Transcription Factors; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf