title: Refractory Demodex folliculitis in five children with acute lymphoblastic leukemia.
abstract: We report five children with acute lymphocytic leukemia on maintenance chemotherapy who had Demodex folliculitis. None experienced complete clearing when treated with permethrin 5% cream. Topical metronidazole helped to lessen the eruption in four, but did not provide full clearing. The one child who was treated with sodium sulfacetamide 10%, sulfur 5% formulation had resolution of the eruption. We suggest that treatment of Demodex folliculitis in children with acute lymphocytic leukemia is more difficult than is suggested in the literature. Newer sodium sulfacetamide/sulfur formulations should be considered when treating this condition, particularly in children with acute lymphocytic leukemia.
authors.affiliation: Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Herron
authors.forename: Margretta A
authors.initials: MA
authors.lastname: O'reilly
authors.forename: Sheryll L
authors.initials: SL
authors.lastname: Vanderhooft
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D005499:Folliculitis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008924:Mite Infestations / Q000188:drug therapy* / Q000209:etiology; D026023:Permethrin / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D013409:Sulfacetamide / Q000008:administration & dosage; D013457:Sulfur Compounds / Q000008:administration & dosage; D017211:Treatment Failure
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D013457:Sulfur Compounds; D008795:Metronidazole; D013409:Sulfacetamide; D026023:Permethrin