title: [HCV: immune response and its modifiers in clinical development].
abstract: Host immunological response is one of the major factors determining natural history of HCV infection. Disturbances of cellular immune response, especially dynamic Th1/Th2 balance and Th2 response domination seems to be the reason of HCV persistence. Recent therapeutic strategies based on immunomodulatory agents like interferon and ribavirin. Interferon action is regulated by many factors including immunological. In the work the results of experimental and clinical trials evaluating safety, tolerance and efficacy of interferon others as alpha were described. While the mechanism of immune modifiers is not clearly understood, various immunomodulatory agents are being studied for HCV-infected patients.
authors.affiliation: Katedra i Klinika Chorób Zakaźnych i Hepatologii Collegium Medicum, Uniwersytetu Mikołaja Kopernika w Toruniu. kikchzak@cm.umk.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pawłowska
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D004359:Drug Therapy, Combination; D016174:Hepacivirus / Q000187:drug effects* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000187:drug effects* / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007370:Interferon Type I / Q000494:pharmacology; D016898:Interferon-alpha / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology; D011994:Recombinant Proteins; D012254:Ribavirin / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D018937:Hepatitis C Antibodies; D007370:Interferon Type I; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin; C050739:interferon alfacon-1; D007372:Interferons