title: Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions.
abstract: [reaction: see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Lu
authors.forename: Xin-Yong
authors.initials: XY
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.forename: Jian
authors.initials: J
authors.lastname: Wan
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D003512:Cyclohexanones; C036468:cyclohexanone; C116609:3-hydroxybutanal; D011392:Proline; C056291:prolinamide