Floratheasaponins A-C, acylated oleanane-type triterpene oligoglycosides with anti-hyperlipidemic activities from flowers of the tea plant (Camellia sinensis).
The methanolic extract and its n-butanol-soluble fraction from the flowers of the tea plant (Camellia sinensis) were found to suppress serum triglyceride elevation in olive oil-treated mice. From the n-butanol-soluble fraction, three new acylated oleanane-type triterpene oligoglycosides, floratheasaponins A-C (1-3), were isolated together with several flavonol glycosides and catechins. The structures of 1-3 were elucidated on the basis of chemical and physicochemical evidence as 21-O-angeloyl-22-O-acetyltheasapogenol B 3-O-[beta-D-galactopyranosyl(1-->2)][beta-D-xylopyranosyl(1-->2)-alpha-L-arabinopyranosyl(1-->3)]-beta-D-glucopyranosiduronic acid, 21,22-di-O-angeloyl-R1-barrigenol 3-O-[beta-D-galactopyranosyl(1-->2)][beta-D-xylopyranosyl(1-->2)-alpha-L-arabinopyranosyl(1-->3)]-beta-D-glucopyranosiduronic acid, and 21-O-angeloyl-22-O-2-methylbutyryl-R1-barrigenol 3-O-[beta-D-galactopyranosyl(1-->2)][beta-D-xylopyranosyl(1-->2)-alpha-L-arabinopyranosyl(1-->3)]-beta-D-glucopyranosiduronic acid, respectively. Floratheasaponins (1-3) showed inhibitory effects on serum triglyceride elevation, with their activities being more potent than those of theasaponins E1 (4) and E2 (5) obtained previously from the seeds of C. sinensis.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
Morikawa
Toshio
T
Yamamoto
Kaori
K
Kato
Yasuyo
Y
Nagatomo
Akifumi
A
Matsuda
Hisashi
H
D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D008297:Male; D051379:Mice; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000960:Hypolipidemic Agents; D000069463:Olive Oil; D010938:Plant Oils; D012503:Saponins; D014315:Triterpenes; C505301:floratheasaponin A; C505302:floratheasaponin B; C505303:floratheasaponin C; C413246:oleanane; D009828:Oleanolic Acid