title: Deep venous thrombosis in a patient with Behçet's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills.
abstract: Behçet's disease (BD) is a multisystemic disease of unknown aetiology characterized by chronic relapsing oral aphthous lesions, genital ulcers, uveitis, and vasculopathy of both arteries and veins of all sizes. We present the case of a female patient, with BD on oral contraceptive pills, who sustained deep venous thrombosis of the long saphenous vein. The patient was found to be a carrier of a homozygous mutation of the prothrombin (factor II) G20210A gene. Our case suggests that a thrombophilia work-up may be warranted in BD patients, especially young women before they are prescribed oral contraceptives.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, 113-6044, Beirut, Lebanon. iuthman@aub.edu.lb
authors.forename: Imad
authors.initials: I
authors.lastname: Uthman
authors.forename: Zaher
authors.initials: Z
authors.lastname: Otrock
authors.forename: Ali
authors.initials: A
authors.lastname: Taher
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006720:Homozygote; D006801:Humans; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: D003276:Contraceptives, Oral; D011516:Prothrombin