Gender-related differences in rhythm control treatment in persistent atrial fibrillation: data of the Rate Control Versus Electrical Cardioversion (RACE) study.
OBJECTIVE
This study sought to compare whether gender affects the outcome of rate versus rhythm control treatment in patients with persistent atrial fibrillation (AF).


BACKGROUND
Large trials have shown that rate control is an acceptable alternative to rhythm control. However, the effects of treatment may differ between male and female patients.


METHODS
In the Rate Control versus Electrical Cardioversion (RACE) study, 522 patients (192 female) were included and randomized to rate or rhythm control. The occurrence of cardiovascular end points and quality of life (QoL) were compared between female and male patients.


RESULTS
At baseline, female patients differed from male patients with regard to age, underlying heart disease, diabetes mellitus, and left ventricular function. Female patients had more AF-related complaints, and QoL was significantly lower. After a mean follow-up of 2.3 +/- 0.6 years, cardiovascular morbidity and mortality was equally distributed between female (21%) and male patients (19%). However, in contrast to male patients, female patients randomized to rhythm control developed more end points (adjusted hazard ratio was 3.1 [95% confidence interval 1.5 to 6.3], p = 0.002), mainly heart failure, thromboembolic complications, and adverse effects of antiarrhythmic drugs, compared with rate control randomized female patients. During follow-up, QoL in female patients remained worse compared with that for male patients. Randomized strategy did not influence QoL in female patients.


CONCLUSIONS
In female patients with persistent AF, a rhythm control approach leads to more cardiovascular morbidity and mortality. Because treatment strategy did not influence QoL in female patients, a rate control approach may be considered in these patients.
Rienstra
Michiel
M
Department of Cardiology, University Medical Center, University of Groningen, Groningen, The Netherlands.
Van Veldhuisen
Dirk J
DJ
Hagens
Vincent E
VE
Ranchor
Adelita V
AV
Veeger
Nic J G M
NJ
Crijns
Harry J G M
HJ
Van Gelder
Isabelle C
IC
D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality; D004554:Electric Countershock; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D012727:Sex Characteristics