title: The influence of product instability on slow-binding inhibition.
abstract: We present a kinetic study of an enzyme reaction that takes place with slow-binding inhibition where the immediate product undergoes a spontaneous or induced process of decomposition. A kinetic study of an enzyme process, in which a slow-binding inhibition process and a decomposition of the immediate product of the reaction take place simultaneously is performed. The corresponding explicit concentration-time equations were obtained. Using the analytical solutions obtained, which were tested numerically, we suggest a procedure that allows the discrimination between the particular cases considered and the evaluation of the principal kinetic parameters of the reaction.
authors.affiliation: Departamento de Química-Física, Escuela Politécnica Superior, Universidad de Castilla-La Mancha Avda, España, s/n Campus Universitario, E-02071 Albacete, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Garrido-Del Solo
authors.forename: J M
authors.initials: JM
authors.lastname: Yago
authors.forename: M
authors.initials: M
authors.lastname: García-Moreno
authors.forename: B H
authors.initials: BH
authors.lastname: Havsteen
authors.forename: F
authors.initials: F
authors.lastname: García-Cánovas
authors.forename: R
authors.initials: R
authors.lastname: Varón
mesh_terms: D004791:Enzyme Inhibitors; D004798:Enzymes / Q000493:pharmacokinetics*; D008432:Mathematical Computing; D008962:Models, Theoretical; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes