[Immunological classification of 112 adult acute leukemia patients].
OBJECTIVE
To explore the criteria and significance of immunological classification in adult acute leukemias.


METHODS
One or two color monoclonal antibodies directly labeled with immunofluorescence were used to analyse the surface and cytoplasma antigens by flow cytometry, and an antibody integral system was developed for the immunologic classification.


RESULTS
One hundred and twelve adult acute leukemia cases were detected. (1) The undifferentiated phenotype account for 0.9%, simple 51.8%, variant 38.4% and mixed lineage 8.9%. (2) The abnormal expressions of antigen in variant and mixed lineage phenotype were CD7, CD33, CD10, CD13, CD19 and CD20, by order of decreased level.


CONCLUSIONS
The strict, numerical diagnostic criteria was very convenient and useful for immunophenotyping of adult acute leukemia.
Dai
H
H
Anhui Provincial Hospital, Hefei 230001, China.
D000208:Acute Disease; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000145:classification / Q000276:immunology*; D008297:Male
D018952:Antigens, CD34; D006684:HLA-DR Antigens