[Effect of oxidative processes in lipids on the formation of the biological response during combined exposure to X-rays and chemical agents].
It shown that the preliminary administration of the low toxic surfactant (Tween 80) and of acetone at low doses increases the action of the acute X-rays with sublethal and lethal doses on the living organisms. The absence of the linear dependence between the biochemical changes of the lipid peroxidation (LPO) regulatory system and initial levels of parameters of this system was found. The gain of the effect of the action on the LPO intensity in tissues and the changes in the scale and direction of the interrelation between the antioxidative status parameters in murine liver under combined exposure of the damaging factors of the chemical and physical nature was found.
Urnysheva
V V
VV
Kozlov
M V
MV
Shishkina
L N
LN
D000096:Acetone / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011136:Polysorbates / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D014965:X-Rays / Q000009:adverse effects
D011136:Polysorbates; D000096:Acetone