Axonal sprouting of GABAergic interneurons in temporal lobe epilepsy.
Temporal lobe epilepsy is one of the most common forms of epilepsy. Numerous contributing factors and compensatory mechanisms have been associated with temporal lobe epilepsy. One feature found in both humans and animal models is sprouting of hippocampal principal cell axons, which suggests that axonal sprouting may be a general phenomenon associated with temporal lobe epilepsy. This article highlights the evidence showing that hippocampal GABAergic interneurons also undergo axonal sprouting in temporal lobe epilepsy. The caveats and unanswered questions associated with the current data and the potential physiological consequences of reorganizations in GABAergic circuits are discussed.
Bausch
Suzanne B
SB
Department of Pharmacology, Program in Neuroscience, Uniformed Services University, Room C2007, 4301 Jones Bridge Road, Bethesda, MD 20814, USA. sbausch@usuhs.mil
D001369:Axons / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005680:gamma-Aminobutyric Acid