title: Myelodysplastic syndromes: clinicopathologic features, pathobiology, and molecular pathogenesis.
abstract: BACKGROUND
  Myelodysplastic syndromes (MDSs) are clonal stem cell diseases characterized by ineffective hematopoiesis, multilineage dysplasia, and peripheral cytopenias with normocellular or hypercellular marrow. They represent a heterogeneous group of disorders with a varied spectrum of clinical, morphologic, biologic, and genetic characteristics. This heterogeneity in disease characterization has led to evolving classification systems, developing prognostic models, and continuing research efforts to elucidate its pathobiology and pathogenesis.
  
  
  OBJECTIVE
  To summarize updated information and provide a general overview of the clinicopathologic features, pathobiology, and cytogenetic and molecular pathogenesis of MDSs.
  
  
  METHODS
  Relevant articles indexed in PubMed (National Library of Medicine) between 1982 and 2005 and reference medical texts.
  
  
  CONCLUSIONS
  Although MDSs remain a relatively poorly defined disease entity, recent advancements in cytogenetic and molecular studies have significantly contributed to our present knowledge of MDSs. Novel strategies for studying the pathogenesis and evolution of MDSs continue to shape our understanding of this disease and guide our approaches to diagnosis and treatment.
authors.affiliation: Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: Ha Thanh
authors.initials: HT
authors.lastname: Nishino
authors.forename: Chung-Che
authors.initials: CC
authors.lastname: Chang
mesh_terms: D003582:Cytogenetics; D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D004247:DNA