A new antitumor compound from the plant Oryctanthus sp. as a VEGF receptor binding inhibitor.
The 70% aqueous methanolic extract of the Peruvian plant Oryctanthus sp. was found to contain a novel saccharide of a diene alpha,omega-diacid. Compound 1 was identified as an inhibitor of the VEGF receptor. The structure of this compound was established based on NMR studies. Compound 1 inhibited ligand binding to the VEGF receptor with an IC50 of 5.0 microM.
Hegde
Vinod R
VR
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hegde@spcorp.com
Pu
Haiyan
H
Patel
Mahesh
M
Jachens
Adrian
A
Gullo
Vincent P
VP
Chan
Tze-Ming
TM
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D015394:Molecular Structure; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D040262:Receptors, Vascular Endothelial Growth Factor