Hepatitis C virus-associated glomerulonephritis without hepatitis C virus in the blood.
An 82-year-old woman with nephrotic syndrome and a 61-year-old woman with proteinuria and purpura on the lower extremities are reported. Both patients had test results positive for hepatitis C virus (HCV) antibody, but HCV RNA was not detected in the blood of either patient. The kidney biopsy showed membranoproliferative glomerulonephritis with capillary deposition of C3 and immunoglobulin M, indicating HCV-associated glomerulonephritis. These cases are suggestive to study the pathogenesis of this disease.
Yamabe
Hideaki
H
Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan. yamabe@cc.hirosaki-u.ac.jp
Nakamura
Norio
N
Nakamura
Masayuki
M
Shimada
Michiko
M
Kumasaka
Ryuichiro
R
Fujita
Takeshi
T
Osawa
Hiroshi
H
Okumura
Ken
K
Oyama
Naoto
N
Momose
Akishi
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D003176:Complement C3 / Q000032:analysis; D005153:Facial Neoplasms / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology; D006333:Heart Failure / Q000209:etiology; D016174:Hepacivirus / Q000276:immunology*; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology*; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000209:etiology; D011183:Postoperative Complications / Q000276:immunology; D012367:RNA, Viral / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012217:Rheumatoid Factor / Q000032:analysis / Q000276:immunology
D003176:Complement C3; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral; D012217:Rheumatoid Factor