[Effects of Danshen injection on the reserve of tissue plasminogen activator and nitric oxide in endothelium and vasodilatation in diabetic patients].
OBJECTIVE
To investigate the effects of Danshen Injection on the reserve of tissue plasminogen activator and nitric oxide in endothelium and vasodilatation in diabetic patients.


METHODS
32 patients and 16 normal individuals were enrolled into this study. The capacity of vascular endothelium to release tPA and NO was examined by venous occlusion of the upper arm. Brachial artery diameter was measured at baseline, during post occlusion reactive hyperemia (flow-mediated endothelium-dependent), and after sublingual nitroglycerol administration (endothelium-independent). Vasodilation was expressed as the percentage changes relative to the baseline diameter, while endothelial tPA and NO release was expressed as the percentage change relative to the baseline tPA and NO levels. Thickness of the intima of carotid artery was measured using ultrasound imaging.


RESULTS
There was no significant difference in eudothelum-independent vasodilation between the controls and diabetes. However, significant reduction in endothelium-dependent vasodilation, endothelial NO release and tPA release (P <0.05, or P <0.01) were found in diabetes compared with the controls and the reduction was lower in diabetes with hypertension than that in diabetes without it. At the same time, there was no difference in intimamedial thickness of the carotid artery between two groups, although the carotid artery in the diabetes without hypertension was much thicker than that in the control. But that in the diabetes with hypertension had significant difference compared with that in the control.


CONCLUSIONS
Danshen Injection may improve the above-mentioned marks. And it may increase the endothelium-dependent vasodilation and endothelial tPA and NO release and improve the vascular disease in patients with diabetes mellitus.
Zhang
Mei
M
The First Hospital, Xi' an Jiaotong University, Xi'an.
Li
Xu
X
Qin
Genquan
G
Liu
Yi
Y
Zhao
Xiaorui
X
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D014665:Vasodilator Agents; D009569:Nitric Oxide; D010959:Tissue Plasminogen Activator