Asymmetric cell division in skin development: a new look at an old observation.
During skin development, the single-layered surface ectoderm covering the mouse embryo must initiate stratification and terminal differentiation to develop a functional epidermis. A recent article by Lechler and Fuchs in Nature (Lechler and Fuchs, 2005) suggests that these events are triggered by asymmetric cell division.
Koster
Maranke I
MI
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Roop
Dennis R
DR
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division; D000078404:Epidermal Cells; D004817:Epidermis / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D007633:Keratins / Q000378:metabolism; D051379:Mice
D007633:Keratins