title: Debridement via collagenase application in two neonates.
abstract: Slow-healing wounds contain insufficient amounts of intrinsic collagenases to provide sufficient wound debridement, so that the use of products containing synergistic collagenases and proteases may be helpful. We report the successful use of collagenase clostridipeptidase A in two newborns, a premature infant with 3rd degree burns, and a term neonate with an extravasation necrosis caused by calcium gluconate. Surgical excision of necrotic tissue is a serious intervention and prolongs the duration of hospitalization. Enzymatic eschar removal may have an advantage over surgery especially in newborns with a high risk for surgery, with its possible complications, need for anesthesia, and perhaps for blood transfusion.
authors.affiliation: Department of Pediatrics, Ankara Training and Research Hospital, Ankara, Turkey.
authors.forename: Ulku
authors.initials: U
authors.lastname: Tiras
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Ayse Anil
authors.initials: AA
authors.lastname: Karabulut
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Dallar
authors.forename: H Meral
authors.initials: HM
authors.lastname: Eksioglu
mesh_terms: D002056:Burns / Q000628:therapy*; D002057:Burns, Chemical / Q000628:therapy; D017364:Collagenases; D003646:Debridement / Q000379:methods*; D003879:Dermatologic Agents; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D003012:Microbial Collagenase
chemical_list: D003879:Dermatologic Agents; D017364:Collagenases; D003012:Microbial Collagenase