title: [Intracoronary inflammatory markers after percutaneous coronary interventions].
abstract: OBJECTIVE
  To analyze intracoronary release of inflammatory markers (IM) after percutaneous coronary interventions (PCI) and compare their concentrations concerning the type of PCI used (rotablator vs. balloon angioplasty).
  
  
  METHODS
  Twenty-two patients with average age of 60 +/- 11.9 years old, 12 of male sex, with stable coronary disease, submitted to elective treatment of a single coronary lesion, using rotablator (N = 11) or balloon pre-dilatation (N = 11) for stent implant were randomized. Samples were collected at aorta root and coronary sinus, immediately before and 15 minutes after intervention. All dosages were made before stent implant, and the cytokines TNF-a, IL-6 and IL-1 and the soluble adhesion molecules ICAM-1, E-selectin and P-selectin were analyzed by using ELISA method.
  
  
  RESULTS
  TNF-a and IL-6 concentrations increased after PCI, respectively from 9.5 +/- 1.5 pg/ml to 9.9 +/- 1.8 pg/ml (p = 0.017) and from 6.0 +/- 2.4 pg/ml to 6.9 +/- 3.0 pg/ml (p < 0.001). There was no significant changes in IL-1, ICAM-1 and P-selectin, and a decrease in E-selectin concentrations after the procedures (52.0 +/- 17.5 ng/ml to 49.3 +/- 18.7 ng/ml; p = 0.009) was observed. There were no significant differences between IM concentrations after PCI, concerning the type of procedure used.
  
  
  CONCLUSIONS
  At the early period, post-percutaneous coronary interventions, an increase of intracoronary concentrations of TNF-a and IL-6, and absence of significant difference between concentrations of inflammatory markers released in coronary flow through rotablator and balloon angioplasty were observed.
authors.affiliation: Instituto do Coração, Hospital das Clínicas, FMUSP, São Paulo, SP.
authors.forename: Wilson
authors.initials: W
authors.lastname: Salgado Filho
authors.forename: Eulógio E
authors.initials: EE
authors.lastname: Martinez Filho
authors.forename: Pedro
authors.initials: P
authors.lastname: Horta
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Lemos
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Migueletto
authors.forename: Carlos Vicente
authors.initials: CV
authors.lastname: Serrano
authors.forename: José Antonio Franchini
authors.initials: JA
authors.lastname: Ramires
authors.forename: Tania Leme da Rocha
authors.initials: TL
authors.lastname: Martinez
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017225:Atherectomy, Coronary; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000628:therapy*; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D015607:Stents
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines