Infantile bilateral striatal necrosis associated with human herpes virus-6 (HHV-6) infection.
A 1-year-old female with acute bilateral striatal necrosis secondary to exanthema subitum associated with human herpesvirus 6 (HHV-6) infection is reported. The patient was previously healthy. She presented with progressive neurologic signs of oral dyskinesia and involuntary movements, after suffering from exanthema subitum. Initial magnetic resonance imaging (MRI) demonstrated abnormal signals in the bilateral striatal regions. In addition, the serum HHV-6 IgM class antibody level was significantly increased. The patient is thought to be the first case of HHV-6 infection related infantile bilateral striatal necrosis (IBSN).
Murakami
Aki
A
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Horikoji, Kamigyo, Kyoto 602-8566, Japan. akkylin@koto.kpu-m.ac.jp
Morimoto
Masafumi
M
Adachi
Shinsuke
S
Ishimaru
Yosuke
Y
Sugimoto
Tohru
T
D001480:Basal Ganglia Diseases / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D003342:Corpus Striatum / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D005260:Female; D006566:Herpesviridae Infections / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D015654:Herpesvirus 6, Human / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009336:Necrosis / Q000473:pathology*