Effect of spirulina and Liv-52 on cadmium induced toxicity in albino rats.
Oral administration of cadmium (6mg/kg body weight/day) as cadmium chloride (CdCl2) for 30 days resulted in a significant increase in thiobarbituric acid reactive substances (TBARS) level and a decrease in the levels of copper, zinc, iron, selenium, glutathione, superoxide dismutase, catalase, glutathione peroxidase when compared to normal control. Administration of either Liv-52 alone or in combination with spirulina produced a well pronounced protective effect in respect to these parameters in cadmium intoxicated rats. The protective effect of spirulina and Liv-52 in respect to biochemical changes were also confirmed by histopathological study in the liver and kidney sections.
Jeyaprakash
K
K
Department of Biochemistry, Dr NGPArts & Science College, Kovai Medical Center Research & Educational Trust, Coimbatore 641 014, India. jeypee5@rediffmail.com
Chinnaswamy
P
P
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001067:Appetite Depressants / Q000494:pharmacology; D001426:Bacterial Proteins / Q000494:pharmacology*; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride / Q000633:toxicity; D002374:Catalase / Q000097:blood; D003300:Copper / Q000097:blood; D004338:Drug Combinations; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D007501:Iron / Q000097:blood; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000097:blood; D053545:Spirulina; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D015032:Zinc / Q000097:blood
D000975:Antioxidants; D001067:Appetite Depressants; D001426:Bacterial Proteins; D004338:Drug Combinations; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D002104:Cadmium; C002614:Liv 52; D003300:Copper; D007501:Iron; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D012643:Selenium; D015032:Zinc; D019256:Cadmium Chloride