[Antiinflammatory and antiulcer effect of oxymethyluracil].
Enteral administration of oxymethyluracil in non-inbred albino rats decreased the inflammatory reaction to histamine, serotonin, bradykinin, carrageenan and trypsin, (being similar to voltaren) and reduced granulomatous inflammation, but influenced the proliferation to a lower extent than did voltaren. In contrast to voltarcen, oxymethyluracil also exhibited gastroprotective antiulcer properties.
Lazareva
D N
DN
Davydova
V A
VA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage*; D001920:Bradykinin / Q000633:toxicity; D002351:Carrageenan / Q000633:toxicity; D004008:Diclofenac / Q000008:administration & dosage; D006632:Histamine / Q000633:toxicity; D018494:Histamine Agents / Q000633:toxicity; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051381:Rats; D012701:Serotonin / Q000633:toxicity; D018490:Serotonin Agents / Q000633:toxicity; D014357:Trypsin / Q000633:toxicity; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014665:Vasodilator Agents / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D018494:Histamine Agents; D018490:Serotonin Agents; D014665:Vasodilator Agents; D004008:Diclofenac; D012701:Serotonin; D014498:Uracil; C003029:oxymethacil; D006632:Histamine; D002351:Carrageenan; D014357:Trypsin; D001920:Bradykinin