Crystalline lens optical dysfunction through aging.
OBJECTIVE
To evaluate the optical and densitometric changes that take place in the crystalline lens with aging.


METHODS
Cross-sectional study.


METHODS
Seventy-two eyes of 72 patients of different ages (8-80 years) with a clear lens, a visual acuity of 20/25 or better, and no ocular disease.


METHODS
In each case, the lens thickness, optical density, modulation transfer function (MTF), and intraocular aberrations were measured.


METHODS
Embryonic and fetal nucleus density, lens thickness, intraocular high-order aberration (HOA), and 0.1 MTF.


RESULTS
Embryonic, anterior, and posterior fetal nucleus densities show a positive correlation with age (P<0.0001, P<0.0001, and P<0.0001, respectively). Lens thickness also shows a positive correlation with age (P<0.0001). Total ocular and corneal HOAs for a 6-mm pupil show a positive correlation with age (P = 0.036 and P<0.0001, respectively). Ocular and corneal Zernike polynomials Z4i+Z6i and intraocular spherical aberration (Z4(0)) also show a positive correlation with age (P = 0.001, P = 0.039, and P = 0.001, respectively). Intraocular coma aberration (Z3(-1)) shows a negative linear correlation with age (P<0.0001). In addition, 0.1 MTF decreased with age from 18.557 to 10.100 cycles per degree.


CONCLUSIONS
There is a degradation of the optical quality of the crystalline lens with aging that is associated with morphological changes (thickness and density). These results are important for the consideration of lens replacement in the absence of evident cataract.
Alió
Jorge L
JL
Research, Development, and Innovation Department, VISSUM, Instituto Oftalmológico de Alicante, Alicante, Spain. jlalio@vissum.com
Schimchak
Patricia
P
Negri
Herminio P
HP
Montés-Micó
Robert
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002648:Child; D003430:Cross-Sectional Studies; D003720:Densitometry; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010781:Photography; D014792:Visual Acuity / Q000502:physiology