Barbiturate withdrawal--a nomogram for supplementary dosing after the phenobarbitone loading technique.
A case of a woman who presented with a multiple drug overdose and then subsequently had a withdrawal syndrome complicated by seizures and delirium highlights the seriousness of the barbiturate withdrawal syndrome. The patient had a short elimination half-life for phenobarbitone and required supplementary phenobarbitone doses to prevent and treat these complications. We have devised a nomogram which in conjunction with serum levels allows a rapid determination of whether and how much supplementary doses are required during barbiturate withdrawal.
Buckley
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Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia.
Foy
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