A [5]HELOL analogue that senses remote chirality in alcohols, phenols, amines, and carboxylic acids.
A route is developed to a structural analogue of [5]HELOL, a previously reported helically grooved sensor of remote chirality. It gives the material enantiomerically pure and in multigram quantities. The enantiomers of alcohols, phenols, amines, and carboxylic acids, even when their centers of chirality are remote from any functional groups, can be differentiated by 31P NMR spectroscopic analyses of their reaction products with the chlorophosphite of this material.
Wang
David Zhigang
DZ
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Katz
Thomas J
TJ