title: HapSim: a simulation tool for generating haplotype data with pre-specified allele frequencies and LD coefficients.
abstract: We have developed a simulation tool HapSim for the generation of haplotype data. The simulated haplotypes are such that their allele frequencies and linkage disequilibrium coefficients match exactly those estimated in a real sample.
  
  
  BACKGROUND
  The program is available as an R package and can be downloaded from http://cran.r-project.org/.
authors.affiliation: Department of Mathematics, Imperial College London, UK. g.montana@imperial.ac.uk
authors.forename: Giovanni
authors.initials: G
authors.lastname: Montana
mesh_terms: D000465:Algorithms; D000483:Alleles; D002874:Chromosome Mapping; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D003198:Computer Simulation; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D012984:Software
chemical_list: D005819:Genetic Markers; D004247:DNA; D007703:Peptidyl-Dipeptidase A