Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.
The present nomenclature of the splice variants of the lysosome-associated membrane protein type 2 (LAMP-2) is confusing. The LAMP-2a isoform is uniformly named in human, chicken, and mouse, but the LAMP-2b and LAMP-2c isoforms are switched in human as compared with mouse and chicken. We propose to change the nomenclature of the chicken and mouse b and c isoforms to agree with that currently used for the human isoforms. To avoid confusion in the literature, we further propose to adopt the use of capital letters for the updated nomenclature of all the isoforms in all three species: LAMP-2A, LAMP-2B, and LAMP-2C.
Eskelinen
Eeva-Liisa
EL
University of Kiel, Institute of Biochemistry, Kiel, Germany. eeva-liisa.eskelinen@helsinki.fi
Cuervo
Ana Maria
AM
Taylor
Matthew R G
MR
Nishino
Ichizo
I
Blum
Janice S
JS
Dice
J Fred
JF
Sandoval
Ignacio V
IV
Lippincott-Schwartz
Jennifer
J
August
J Thomas
JT
Saftig
Paul
P
D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D030541:Databases, Genetic; D006801:Humans; D008247:Lysosomes / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D009626:Terminology as Topic
D020033:Protein Isoforms