Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
In this review, we discuss recent data from our laboratory that address two aspects of major histocompatibility complex (MHC) class I-restricted antigen processing. First, we consider the nature of the peptide-loading complex, which is the assembly of proteins in the endoplasmic reticulum (ER) into which newly synthesized MHC class I-beta(2) microglobulin (beta(2)m) heterodimers are incorporated, and the mechanisms involved in MHC class I assembly and peptide loading that are facilitated by the peptide-loading complex. Second, we discuss mechanisms of cross-presentation, the phenomenon whereby extracellular and luminal protein antigens can be processed by antigen-presenting cells, particularly dendritic cells, and presented by MHC class I molecules to CD8(+) T cells. The focus of the discussion is mainly on the human MHC class I system.
Cresswell
Peter
P
Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. peter.cresswell@yale.edu
Ackerman
Anne L
AL
Giodini
Alessandra
A
Peaper
David R
DR
Wearsch
Pamela A
PA
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D045142:Cross-Priming / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology / Q000378:metabolism
D015395:Histocompatibility Antigens Class I; D010455:Peptides