Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus.
We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters.
Paisley
Derek
D
Clinical Sciences Building, Hope Hospital, Salford, UK.
Robson
Geoffrey D
GD
Denning
David W
DW
D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D001232:Aspergillus fumigatus / Q000145:classification / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity*; D048708:Cell Growth Processes / Q000502:physiology*; D051379:Mice; D014774:Virulence