title: [High prevalence of thyroid disfunction in primary hyperaldosteronism].
abstract: Primary hyperaldosteronism is associated with other endocrinology pathologies, like pheochromocytoma, Cushing's syndrome, hyperprolactinemia, primary hyperparathyroidism and a type of multiple endocrine neoplasia. Furthermore, association between hyperaldosteronism and thyroid diseases were already pointed out. Aim of the study was to value the prevalence of some thyroid diseases in a series of patients with primary hyperaldosteronism. We studied 105 consecutive patients with primary hyperaldosteronism, 43 (40.95%) with adrenal adenoma, 62 (50.05%) with bilateral adrenal hyperplasia and a control group of 223 patients with essential arterial hypertension. In all patients we tested thyroid function (FT3, FT4, TSH), thyroid antibodies (AbTPO, AbTG) and, sometimes, thyroid morphology by ultrasonography (US scan). The results of the study show that thyroid disfunction occur in 28.6% of patients with primary hyperaldosteronism and in 16.6% of patients with essential hypertension, with a statistically significative difference (chi2 = 0.012). At present, the relationship between primary hyperaldosteronism and thyroid diseases is unclear, but it can be hypothesized that there are common pathogenetic mechanisms, like an imbalance between various growth factors. Further studies are necessary to confirm the results of our study.
authors.affiliation: Day Hospital di Medicina Interna e dell'Ipertensione Arteriosa, Dipartimento di Scienze Cliniche.
authors.forename: Chiara
authors.initials: C
authors.lastname: Santori
authors.forename: Claudio
authors.initials: C
authors.lastname: Di Veroli
authors.forename: Francesca
authors.initials: F
authors.lastname: Di Lazzaro
authors.forename: Chiara
authors.initials: C
authors.lastname: Caliumi
authors.forename: Luigi
authors.initials: L
authors.lastname: Petramala
authors.forename: Dario
authors.initials: D
authors.lastname: Cotesta
authors.forename: Monica
authors.initials: M
authors.lastname: Iorio
authors.forename: Valentina
authors.initials: V
authors.lastname: Serra
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Celi
authors.forename: Emilio
authors.initials: E
authors.lastname: D'Erasmo
authors.forename: Claudio
authors.initials: C
authors.lastname: Letizia
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013959:Thyroid Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones