Hippocampal theta rhythms from a computational perspective: code generation, mood regulation and navigation.
In this paper three computer models are summarized discussing different functions of the cortico-hippocampal system. Mood regulation, rhythm and code generation and navigation are integrated into a coherent conceptual framework around the concepts of structural hierarchy and circular causality. First, a model of spatio-temporal code generation is reviewed in which the hippocampal population theta rhythm plays an important role. Next, generation and pharmcological modulation of this rhythm is examined using a computer model of multiple cell populations forming a feed-back loop within the hippocampus and between the septum and the hippocampus. Last, an abstract, but biologically motivated model of navigation is described which achieves a near optimal mode of navigation by composing hierarchical levels of the cortico-hippocampal system. The connections among the different hierarchical structures of the cortico-hippocampal organization and their functional roles are discussed.
Erdi
Péter
P
Center for Complex Systems Studies, Kalamazoo College, Kalamazoo, Michigan Kalamazoo, MI 49006, USA. perdi@kzoo.edu
Huhn
Zsófia
Z
Kiss
Tamás
T
D000339:Affect / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D003198:Computer Simulation; D006624:Hippocampus / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D008568:Memory / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D051381:Rats; D013826:Theta Rhythm