Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein e by hepatocytes.
Acrolein modification of apolipoprotein (apo) E in human very low density lipoprotein (VLDL) was suppressed by ascorbate. Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. These results suggest that ascorbate can play an important role in maintaining proper lipoprotein metabolism by the antioxidant effect.
Arai
Hirofumi
H
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine, Ube 755-8505, Japan.
Uchida
Koji
K
Nakamura
Kazuyuki
K
D000171:Acrolein / Q000737:chemistry / Q000378:metabolism*; D000975:Antioxidants / Q000494:pharmacology; D001057:Apolipoproteins E / Q000378:metabolism*; D001205:Ascorbic Acid / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D010084:Oxidation-Reduction
D000975:Antioxidants; D001057:Apolipoproteins E; D008079:Lipoproteins, VLDL; D000171:Acrolein; D001205:Ascorbic Acid