Shortcut method for evaluation and design of a hybrid process for enantioseparations.
Hybrid processes for enantioseparations have a considerable potential for reducing investment and operational costs. An example is the combination of simulated moving bed (SMB) chromatography and selective crystallisation. However, the design of integrated processes is a difficult task. A shortcut method is presented that can serve as a tool for design and estimation of the potential of such processes. The approach requires only limited experimental data and thus allows for systematic parameter studies. The method is based on the determination of the purity-performance characteristic of the SMB process and rigorous application of mass balances. The use of relative mass fluxes allows derivation of simple algebraic expressions for essential process parameters. The significant potential of combining SMB and crystallisation is demonstrated for the example of the separation of mandelic acid enantiomers.
Kaspereit
Malte
M
Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, D-39106 Magdeburg, Germany. kaspereit@mpi-magdeburg.mpg.de
Gedicke
Knut
K
Zahn
Volker
V
Mahoney
Alan W
AW
Seidel-Morgenstern
Andreas
A
D002845:Chromatography / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations