title: Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?
abstract: Different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset Alzheimer's disease (LOAD) symptoms. Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls. No evidence of association was observed when these polymorphisms were compared separately; however, the combination of the MAOA allele 1+the short allele of 5-HTTLPR+ApoE-epsilon4 was significantly more frequent in patients than in controls. It reinforces the hypothesis that different genes acting together might play a role in AD susceptibility. Based on these data, we suggest replicating these studies in larger samples of LOAD patients belonging to different ethnic groups.
authors.affiliation: Human Genome Research Center, Biology Department, Institute of Biosciences, São Paulo University (IBUSP), São Paulo, Brazil.
authors.forename: Agnes L
authors.initials: AL
authors.lastname: Nishimura
authors.forename: Camila
authors.initials: C
authors.lastname: Guindalini
authors.forename: João R M
authors.initials: JR
authors.lastname: Oliveira
authors.forename: Ricardo
authors.initials: R
authors.lastname: Nitrini
authors.forename: Valéria S
authors.initials: VS
authors.lastname: Bahia
authors.forename: Paulo R
authors.initials: PR
authors.lastname: de Brito-Marques
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Otto
authors.forename: Mayana
authors.initials: M
authors.lastname: Zatz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics; D001938:Brazil; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
chemical_list: D001057:Apolipoproteins E; D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase