title: [Effect of MAb225 on radiosensitivity of Tca8113 tongue squamous cell carcinoma].
abstract: OBJECTIVE
  The purpose of this study was to invest the effect of epidermal growth factor receptor monoclonal antibody MAb225 on radiosensitivity of tongue squamous cell carcinoma cell Tca8113.
  
  
  METHODS
  Tca8113 cells were treated with different concentrations of MAb225. Radiation dose survival curve was generated from clonogenic survival assay. SERPD0 and survival faction (SF2) was analysed by single hit multi-target (SHMT) radiobiological model using RADMEDIC software. Nude mice with Tca8113 tumor xenografts were treated with MAb225, radiation treatment or both of them. Tumor responses were assessed by tumor growth delay, and t test was used for statistical analysis.
  
  
  RESULTS
  MAb225 enhanced the radiosensitivity of Tca8113 cells. SERD0 of Tca8113 cells treated with 0.5 mg/L MAb225 was 1.23. The survival fraction of cells treated with MAb225 was significantly decreased. Tumor radioresponse could be enhanced by MAb225 (P < 0.05).
  
  
  CONCLUSIONS
  MAb225 could enhance radiosensitivity of tongue squamous cell carcinoma cell.
authors.affiliation: Oral Department of Jinan Central Hospital, Jinan 250012, China.
authors.forename: Ming-Guo
authors.initials: MG
authors.lastname: Wang
authors.forename: Zhong-He
authors.initials: ZH
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Gao
authors.forename: Qing
authors.initials: Q
authors.lastname: Gao
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Yi-Li
authors.initials: YL
authors.lastname: Cai
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D011836:Radiation Tolerance; D014062:Tongue Neoplasms
chemical_list: D000911:Antibodies, Monoclonal