title: Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice.
abstract: The Toll-like receptors (TLRs) and the myeloid differentiation factor 88 (MyD88) are key players in the activation of the innate immune defence during microbial infections. Using different murine infection models, we show that MyD88-dependent signalling is crucial for the activation of the innate immune defence against Streptococcus pneumoniae. Our data demonstrate that both local and systemic inflammatory response to S. pneumoniae depends on the presence of MyD88 to clear bacterial colonization of the upper respiratory tract and to prevent pulmonary and systemic infection in mice. Finally, we described a strong correlation between enhanced bacterial growth in the bloodstream of MyD88-deficient mice and the inability to lower the serum iron concentration in response to infection.
authors.affiliation: SMITTSKYDDSINSTITUTET, Swedish Institute for Infectious Disease Control, Karolinska Institutet, Solna, 171 77 Stockholm, Sweden. Barbara.Albiger@mtc.ki.se
authors.forename: Barbara
authors.initials: B
authors.lastname: Albiger
authors.forename: Andreas
authors.initials: A
authors.lastname: Sandgren
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Katsuragi
authors.forename: Ulf
authors.initials: U
authors.lastname: Meyer-Hoffert
authors.forename: Katharina
authors.initials: K
authors.lastname: Beiter
authors.forename: Florian
authors.initials: F
authors.lastname: Wartha
authors.forename: Mathias
authors.initials: M
authors.lastname: Hornef
authors.forename: Staffan
authors.initials: S
authors.lastname: Normark
authors.forename: Birgitta Henriques
authors.initials: BH
authors.lastname: Normark
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics / Q000378:metabolism*; D016470:Bacteremia / Q000276:immunology / Q000382:microbiology; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D053594:Myeloid Differentiation Factor 88; D009305:Nasopharynx / Q000382:microbiology; D011008:Pneumococcal Infections / Q000276:immunology* / Q000382:microbiology*; D011971:Receptors, Immunologic / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013296:Streptococcus pneumoniae / Q000254:growth & development* / Q000472:pathogenicity*; D014132:Trachea / Q000382:microbiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D011971:Receptors, Immunologic