An alternative way of the synthesis of 1-substituted 9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazole derivatives.
A keystone of this work was a modification of synthesis of the title compounds, which were used as substrates for the preparation of amides 5, 9-methoxyolivacine (4a) and ethyl 9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazole-1-carboxylate (4b) were obtained in good overall yields (4a--72%, and 4b--31%) on alternative ways of the synthesis. The pilot results of the cytostatic activity of iminium salts 12a (IC50 = 8 microM) and 12b (IC50 = 2 microM) were determined on L1210 mouse leukaemia cells.
Jasztold-Howorko
Ryszard
R
Wrocław University of Medicine, Faculty of Pharmacy, Department of Organic Chemistry, 9 Grodzka Str., 50-137 Wrocław, Poland. howorko@bf.uni.wroc.pl
Croisy
Alain
A
Carrez
Daniele
D
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004611:Ellipticines / Q000138:chemical synthesis; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice
D000970:Antineoplastic Agents; D004611:Ellipticines; C011521:olivacine