Fast DNA translocation through a solid-state nanopore.
We report experiments and modeling of translocation of double-strand DNA through a siliconoxide nanopore. Long DNA molecules with different lengths ranging from 6500 to 97000 base pairs have been electrophoretically driven through a 10 nm pore. We observe a power-law caling of the translocation time with the length, with an exponent of 1.27. This nonlinear scaling is strikingly different from the well-studied linear behavior observed in similar experiments performed on protein pores. We present a theoretical model where hydrodynamic drag on the ection of the polymer outside the pore is the dominant force counteracting the electrical driving force. We show that this applies to our experiments, and we derive a power-law scaling with an exponent of 1.22, in good agreement with the data.
Storm
Arnold J
AJ
Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 22628 CJ Delft, The Netherlands.
Storm
Cornelis
C
Chen
Jianghua
J
Zandbergen
Henny
H
Joanny
Jean-François
JF
Dekker
Cees
C
D003198:Computer Simulation; D004247:DNA / Q000032:analysis / Q000737:chemistry*; D004058:Diffusion; D008422:Materials Testing; D008567:Membranes, Artificial; D044085:Microfluidics / Q000379:methods*; D008956:Models, Chemical; D008970:Molecular Weight; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry*; D010539:Permeability; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D055672:Static Electricity; D013314:Stress, Mechanical
D008567:Membranes, Artificial; D012822:Silicon Dioxide; D004247:DNA