title: Synthesis of new dihydropyrazines with DNA strand-breakage activity.
abstract: Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused [4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1-6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. maruoka@fukuoka-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruoka
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Kashige
authors.forename: Fumio
authors.initials: F
authors.lastname: Miake
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D003500:Cyclization; D003512:Cyclohexanones / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000187:drug effects*; D004249:DNA Damage; D003959:Diamines / Q000737:chemistry; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D003512:Cyclohexanones; D003959:Diamines; D011719:Pyrazines; C018031:1,2-cyclohexanedione; D004247:DNA