title: 'Scirrhous' type hepatocellular carcinomas: a special reference to expression of cytokeratin 7 and hepatocyte paraffin 1.
abstract: OBJECTIVE
  'Scirrhous' hepatocellular carcinoma (scirrhous HCC) is extremely rare and its characteristics remain unclear. We investigated the clinicopathological and immunohistochemical features of scirrhous HCC, compared with those of ordinary hepatocellular carcinoma (ordinary HCC).
  
  
  RESULTS
  We compared the clinicopathological and immunohistochemical features of 20 resected cases of scirrhous HCC with those of 69 resected cases of ordinary HCC. Scirrhous HCC was characterized by its gross and histological findings, such as a higher proportion of contiguous multinodular type tumours, the absence of a complete fibrous capsule around the tumour, the absence of tumour necrosis and highly preserved portal tracts in the tumour. The immunohistochemical results revealed a significantly higher expression of cytokeratin 7 and a significantly lower expression of hepatocyte paraffin 1 in scirrhous HCC than in ordinary HCC (P<0.0001, respectively). There were no significant differences in proliferative activity and survival curves between the patients with scirrhous HCC and those with ordinary HCC.
  
  
  CONCLUSIONS
  Scirrhous HCC has several particular gross, histological and immunohistochemical features. In particular, we would like to emphasize the greater immunohistochemical expression of cytokeratin 7 and lower expression of hepatocyte paraffin 1 in scirrhous HCC than in ordinary HCC.
authors.affiliation: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences and Department of Clinical Radiology, Kyushu University, Fukuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsuura
authors.forename: S
authors.initials: S
authors.lastname: Aishima
authors.forename: K
authors.initials: K
authors.lastname: Taguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Asayama
authors.forename: T
authors.initials: T
authors.lastname: Terashi
authors.forename: H
authors.initials: H
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Tsuneyoshi
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7; D007633:Keratins / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: C507497:KRT7 protein, human; D053552:Keratin-7; D007633:Keratins