CuI/L-proline-catalyzed coupling reactions of aryl halides with activated methylene compounds.
[reaction: see text] The arylation of ethyl acetoacetate, ethyl benzoyl acetate, and diethyl malonate under the catalysis of CuI/L-proline in DMSO proceeds smoothly at 40-50 degrees C in the presence of Cs2CO3 to provide the 2-aryl-1,3-dicarbonyl compounds in good yields. Both aryl iodides and aryl bromides are compatible with these reaction conditions.
Xie
Xiaoan
X
Department of Chemistry, Fudan University, Shanghai 200433, China.
Cai
Guorong
G
Ma
Dawei
D
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008697:Methane / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*
D001555:Benzene Derivatives; D006846:Hydrocarbons, Halogenated; D007454:Iodides; D003300:Copper; C073870:cuprous iodide; D011392:Proline; D008697:Methane