title: Intermittent injection of bupivacaine into the margin or the cavity after reduction mammaplasty.
abstract: Twenty-seven operated women had postoperative intermittent injections of bupivacaine or saline for 24 hours after reduction mammaplasty. The injections were given five-hourly either subcutaneously along the submammary incision or deep into the wound. The patients were randomised into three groups of nine each: 5 ml bupivacaine 0.25% into the margin; 5 ml bupivacaine 0.25% into the cavity; and 5 ml physiological saline into the cavity. Postoperatively all patients received oral paracetamol and dextropropoxyphene. If additional analgesia was needed morphine was given intravenously. Total morphine consumption was significantly (p<0.03) lower in patients given bupivacaine into the margin (2.0 (0.9) mg) or into the cavity (2.4 (0.8) mg) compared with controls (6.9 (1.5) mg). VAS pain scores and vomiting did not differ among the three groups. Postoperative intermittent infusion of bupivacaine lowered morphine consumption after reduction mammaplasty, and the analgesic effect seemed to be independent of where the infusion was given.
authors.affiliation: Department of Hand and Plastic Surgery, University Hospital, Linköping, Sweden.
authors.forename: Rafael T
authors.initials: RT
authors.lastname: Holmgren
authors.forename: Erkki
authors.initials: E
authors.lastname: Tarpila
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage*; D011431:Dextropropoxyphene / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D016462:Mammaplasty; D009020:Morphine / Q000008:administration & dosage; D010149:Postoperative Pain / Q000188:drug therapy; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000082:Acetaminophen; D012965:Sodium Chloride; D009020:Morphine; D011431:Dextropropoxyphene; D002045:Bupivacaine