title: [Research on the analgesic effect and mechanism of bornyl acetate in volatile oil from amomum villosum].
abstract: OBJECTIVE
  To study the analgesic effect and mechanism of bornyl acetate, the main ingredient of Amomum Villosum Volatile oil.
  
  
  METHODS
  The analgesic effects were tested by pressing tail method. The I, and II phase pain were observed with the pain model caused by formalin test. Influence of naloxone antagonism test on analgesic effect of bornyl acetate.
  
  
  RESULTS
  Bornyl acetate produced obvious analgesic effects on pain models induced by pressing tail. Bornyl acetate had inhibitory effect on I and II phase pain in formalin inducing pain model animals. Analgesic effect induced by Bornyl acetate wasn't significantly reduced by naloxone.
  
  
  CONCLUSIONS
  Bornyl acetate shows analgesic effects. The analgesic site may locate in both central and peripheral nervous system. Its analgesic action way not be related to the opioid receptor.
authors.affiliation: First Affiliated Hospital, Jinan University, Guangzhou.
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wu
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Zhidong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Li
authors.forename: Zhenxia
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001892:Camphanes / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry*; D017288:Pain Threshold / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001892:Camphanes; D004365:Drugs, Chinese Herbal; D009822:Oils, Volatile; C071528:bornyl acetate; D009270:Naloxone