title: Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample.
abstract: BACKGROUND
  Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia.
  
  
  METHODS
  We attempted replication using eight markers from the Canadian study in a UK based sample of 450 cases and 450 supernormal controls.
  
  
  RESULTS
  We found no evidence for allelic or haplotypic association with schizophrenia for any of the markers found to be associated in the Canadian sample.
  
  
  CONCLUSIONS
  The negative results might reflect genetic heterogeneity between the Canadian, Chinese and UK samples or be due to methodological problems. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
authors.affiliation: Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK.
authors.forename: Vinay
authors.initials: V
authors.lastname: Puri
authors.forename: Andrew
authors.initials: A
authors.lastname: McQuillin
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Thirumalai
authors.forename: Jacob
authors.initials: J
authors.lastname: Lawrence
authors.forename: Robert
authors.initials: R
authors.lastname: Krasucki
authors.forename: Khalid
authors.initials: K
authors.lastname: Choudhury
authors.forename: Susmita
authors.initials: S
authors.lastname: Datta
authors.forename: Simon
authors.initials: S
authors.lastname: Kerwin
authors.forename: Digby
authors.initials: D
authors.lastname: Quested
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bass
authors.forename: Jonathan
authors.initials: J
authors.lastname: Pimm
authors.forename: Graham
authors.initials: G
authors.lastname: Lamb
authors.forename: Helen
authors.initials: H
authors.lastname: Moorey
authors.forename: Gomathinayagam
authors.initials: G
authors.lastname: Kandasami
authors.forename: Allison
authors.initials: A
authors.lastname: Badacsonyi
authors.forename: Katie
authors.initials: K
authors.lastname: Kelly
authors.forename: Jenny
authors.initials: J
authors.lastname: Morgan
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Punukollu
authors.forename: Haitham
authors.initials: H
authors.lastname: Nadeem
authors.forename: David
authors.initials: D
authors.lastname: Curtis
authors.forename: Hugh M D
authors.initials: HM
authors.lastname: Gurling
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D002878:Chromosomes, Human, Pair 1; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D006113:United Kingdom
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C488081:NOS1AP protein, human