Anaesthesia of the axillary plexus induces rapid improvement of sensory function in the contralateral hand: an effect of interhemispheric plasticity.
Acute improvement of sensory functions in the contralateral hand during experimental, tourniquet-induced anaesthesia has been described. Tourniquet compression over an extended time period, however, may be painful - which may influence the result. To study the effects of deafferentation of the upper extremity with the pain factor eliminated, we investigated 100 patients with anaesthetised axillary plexus for perception of touch and tactile discrimination in the contralateral (unanaesthetised) hand. Anaesthesia induced a rapid, significant, improvement in tactile discrimination in the contralateral hand, compared with before anaesthesia, measured as two-point discrimination (p=0.0001), and perception of touch, measured with Semmes-Weinstein monofilament (p=0.0005). The improvement lasted as long as the arm was anaesthetised. Understanding the mechanisms of brain plasticity, including interhemispheric plasticity, is essential for designing appropriate strategies for upregulation and downregulation of cortical reorganisational changes to promote sensory relearning after nerve injury.
Björkman
Anders
A
Department of Hand Surgery, University Hospital Malmö, Sweden. anders.bjorkman@hand.mas.lu.se
Rosén
Birgitta
B
Lundborg
Göran
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000758:Anesthesia; D001917:Brachial Plexus / Q000502:physiology*; D005260:Female; D006225:Hand / Q000294:innervation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014111:Tourniquets