title: Heterobifunctional multivalent inhibitor-adaptor mediates specific aggregation between Shiga toxin and a pentraxin.
abstract: [reaction: see text] The first example of a multivalent heterofunctional inhibitor-adaptor, called "BAIT", is described. This multivalent inhibitor-adaptor is able to capture a "target" receptor (Shiga toxin) through its recognition of one ligand of a heterobivalent headgroup while the other ligand binds to an endogenous "trap" protein (serum amyloid P component, SAP). BAIT showed markedly enhanced inhibition of toxin activity. An efficient synthesis of this multivalent cluster containing heterobifunctional ligands was accomplished by chemical and chemoenzymatic approaches.
authors.affiliation: Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Alberta, Edmonton AB, T6G 2G2 Canada.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Solomon
authors.forename: Pavel I
authors.initials: PI
authors.lastname: Kitov
authors.forename: Eugenia
authors.initials: E
authors.lastname: Paszkiewicz
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Grant
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Sadowska
authors.forename: David R
authors.initials: DR
authors.lastname: Bundle
mesh_terms: D002097:C-Reactive Protein / Q000737:chemistry* / Q000378:metabolism*; D006031:Glycosylation; D008024:Ligands; D015394:Molecular Structure; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000737:chemistry / Q000378:metabolism; D022621:Shiga Toxin / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D008024:Ligands; D009419:Nerve Tissue Proteins; D000683:Serum Amyloid P-Component; D022621:Shiga Toxin; D000099153:Pentraxins