The depth of molecular recognition: voltage-sensitive blockage of synthetic multifunctional pores with refined architecture.
Voltage-sensitive blockage by ADP, ATP and phytate (IP6) demonstrates that active-site contraction toward the middle of newly synthesized rigid-rod beta-barrels provides a general strategy to rationally create and modulate the voltage sensitivity (and to increase the efficiency) of molecular recognition by synthetic multifunctional pores.
Baudry
Yoann
Y
Department of Organic Chemistry, University of Geneva, Switzerland.
Pasini
Dario
D
Nishihara
Masamichi
M
Sakai
Naomi
N
Matile
Stefan
S