title: Foveolar choroidal blood flow in idiopathic macular hole.
abstract: OBJECTIVE
  To measure choroidal blood flow from foveal region in the eyes with idiopathic macular hole.
  
  
  METHODS
  Thirteen patients with macular hole and 20 age-matched healthy subjects were included into the study. While group 1 consisted of 13 eyes of idiopathic stage 4 macular hole, seven fellow eyes of the same patients with stage 1a macular hole formed the group 2. The control group (group 3) comprised the randomly selected eye of 20 age-matched healthy subjects. Mean values of blood perfusion parameters that were composed of volume, flow and velocity, were recorded from foveal region of fundus using Heidelberg Retinal Flowmeter (HRF). The differences between the three groups were compared with unpaired t-test, Wilcoxon Signed Rank and Fisher's Exact test using statistical package program.
  
  
  RESULTS
  The mean blood volume and velocity in the eyes with stage 4 macular hole (group 1) and in the eyes with stage 1a macular hole (group 2) were both significantly lower than the eyes in control eyes (group 3) (p < 0.05, unpaired t-test). Although, the mean blood "flow" parameter of group 2 was significantly lower than group 3 ( p < 0.05, unpaired t-test), there was no statistical difference in the "flow" parameter between group 1 and group 3 (p > 0.05, unpaired t-test). The comparison between group 1 and group 2 revealed no significant difference in any perfusion parameter (p > 0.05, Wilcoxon Signed Rank Test).
  
  
  CONCLUSIONS
  Although, it may be result of macular hole, not necessarily the cause of it, these findings suggest that the eyes with idiopathic macular hole are associated with reduced foveolar blood flow. The measurement of the foveolar blood flow from choriocapillaris may be useful for identifying the subjects who have increased risk of development of macular hole in future. The study showed the association of a decrease in foveolar choroidal blood flow in eyes with idiopathic macular hole using HRF. Authors suggested that quantitative measurement of foveolar choroidal blood flow may be helpful for identifying the subjects who have increased risk of development of idiopathic macular hole.
authors.affiliation: Department of Ophthalmology, Medical School of Cerrahpasa, Istanbul University, Ataköy-Istanbu, Turkey. drcaras@Superonline.com
authors.forename: Cengiz
authors.initials: C
authors.lastname: Aras
authors.forename: Ozcan
authors.initials: O
authors.lastname: Ocakoglu
authors.forename: Nilufer
authors.initials: N
authors.lastname: Akova
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001810:Blood Volume; D016022:Case-Control Studies; D002829:Choroid / Q000098:blood supply*; D005260:Female; D045268:Flowmeters; D005584:Fovea Centralis / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D012167:Retinal Perforations / Q000503:physiopathology*