Could MYC induction of mitochondrial biogenesis be linked to ROS production and genomic instability?
MYC has been linked separately to genomic instability and to reactive oxygen species production, but the connection between these two processes has not been firmly established. Our recent study along with previous reports demonstrate that Myc induces nuclear encoded mitochondrial gene expression and mitochondrial biogenesis, thereby directly associating Myc's transcriptional properties, to the production of mitochondrial ROS and the promotion of genomic oxidative damage and genomic instability.
Dang
Chi V
CV
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. cvdang@jhmi.edu
Li
Feng
F
Lee
Linda A
LA
D000818:Animals; D042822:Genomic Instability; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism*; D010084:Oxidation-Reduction; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D016271:Proto-Oncogene Proteins c-myc; D017382:Reactive Oxygen Species