[Glucocorticoids reduce acute postoperative pain].
Glucocorticoids have been used for postsurgical pain relief over the last 30 years. They reduce prostaglandins by inhibiting phospholipase A2 and the expression of COX-2 mRNA. The evidence for an analgesic effect is best after oral, orthopaedic, laparoscopic and perianal surgery. Their anti-emetic properties in addition to the analgesic effects make them particularly useful perioperatively.
Romundstad
Luis
L
Anestesiavdelingen, Rikshospitalet, 0027 Oslo. luisro@medisin.uio.no
Breivik
Harald
H
Stubhaug
Audun
A
D000208:Acute Disease; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage; D019317:Evidence-Based Medicine; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control; D011292:Premedication
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000932:Antiemetics; D016861:Cyclooxygenase Inhibitors; D005938:Glucocorticoids; D008775:Methylprednisolone