title: Severe sepsis in A&E.
abstract: In this article, the author clarifies the definition of sepsis, severe sepsis and septic shock, describes the physiological changes that occur and the initial treatment used to improve patient outcome, and examines the concept of early goal directed therapy (EGDT).
authors.affiliation: Chesterfield Royal Hospital NHS Foundation Trust, Derbyshire.
authors.forename: Wayne
authors.initials: W
authors.lastname: Robson
authors.forename: Julian
authors.initials: J
authors.lastname: Newell
authors.forename: Sarah
authors.initials: S
authors.lastname: Beavis
mesh_terms: D016529:Emergency Nursing / Q000379:methods*; D004636:Emergency Service, Hospital / Q000639:trends; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D018805:Sepsis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D012772:Shock, Septic / Q000175:diagnosis; D013222:State Medicine / Q000639:trends; D016896:Treatment Outcome; D006113:United Kingdom