title: Side and handedness effects on the cingulum from diffusion tensor imaging.
abstract: In order to explore the microstructure of bilateral cingulum bundles associated with side and handedness, fractional anisotropy was extracted from diffusion tensor imaging. Distinguished from the conventional region of interest-based method, a fiber-based analysis method called scale-invariant parameterization method was employed to ascertain the anisotropy along the cingulum bundle in 31 normal right-handers and 14 normal left-handers. The statistical results showed a remarkable left-greater-than-right asymmetry pattern of anisotropy in most segments of cingulum bundles except the most posterior segment, for both right-handers and left-handers. Interestingly, higher anisotropy of the right-hander than the left-hander was found in the bilateral cingulum bundles. No significant handedness-by-side interaction was obtained in the present study, however.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing.
authors.forename: Gaolang
authors.initials: G
authors.lastname: Gong
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.forename: Chaozhe
authors.initials: C
authors.lastname: Zhu
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.forename: Sheng
authors.initials: S
authors.lastname: Xie
authors.forename: Jiangxi
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000328:Adult; D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology