title: Microscopic polyangiitis after silicone breast implantation.
abstract: We describe the case of a patient who developed microscopic polyangiitis (MPA) after silicone breast implantation. A 60-year-old woman who had undergone silicone breast implantation was admitted to our hospital with complaints of general malaise and hematoproteinuria. She was diagnosed as having MPA with evidence of acute progressive renal failure, pulmonary hemorrhage, and positivity for myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA). A renal biopsy showed severe necrotizing and crescentic glomerulonephritis with arteriolitis. The patient received high-dose steroids and plasma exchange treatment, but died of progressive pulmonary hemorrhage and multiple cerebral hemorrhage. Silicone implantation is associated with scleroderma, systemic lupus erythematosus, and rheumatoid arthritis. This case report indicates the possibility of the development of MPA after silicone breast implantation.
authors.affiliation: Department of Nephrology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan, iyoda@med.showa-u.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Iyoda
authors.forename: Jyun
authors.initials: J
authors.lastname: Ito
authors.forename: Hisako
authors.initials: H
authors.lastname: Nagai
authors.forename: Kasumi
authors.initials: K
authors.lastname: Sato
authors.forename: Aki
authors.initials: A
authors.lastname: Kuroki
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
authors.forename: Kozo
authors.initials: K
authors.lastname: Kitazawa
authors.forename: Tetsuzo
authors.initials: T
authors.lastname: Sugisaki
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D019928:Breast Implantation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D020034:Silicone Gels; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology
chemical_list: D020034:Silicone Gels