title: MACiE: a database of enzyme reaction mechanisms.
abstract: CONCLUSIONS
  MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction.
  
  
  BACKGROUND
  http://www-mitchell.ch.cam.ac.uk/macie/.
authors.affiliation: Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Gemma L
authors.initials: GL
authors.lastname: Holliday
authors.forename: Gail J
authors.initials: GJ
authors.lastname: Bartlett
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Almonacid
authors.forename: Noel M
authors.initials: NM
authors.lastname: O'Boyle
authors.forename: Peter
authors.initials: P
authors.lastname: Murray-Rust
authors.forename: Janet M
authors.initials: JM
authors.lastname: Thornton
authors.forename: John B O
authors.initials: JB
authors.lastname: Mitchell
mesh_terms: D002384:Catalysis; D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D016208:Databases, Factual; D030541:Databases, Genetic; D030562:Databases, Protein; D004798:Enzymes / Q000737:chemistry*; D015870:Gene Expression; D016247:Information Storage and Retrieval; D020407:Internet; D008956:Models, Chemical; D015233:Models, Statistical; D011381:Programming Languages; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment; D017421:Sequence Analysis; D012984:Software
chemical_list: D004798:Enzymes; D011506:Proteins