Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites.
Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes.
Walton
Laura J
LJ
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Corre
Christophe
C
Challis
Gregory L
GL
D005990:Glycerol / Q000378:metabolism*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D048630:Polyketide Synthases; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism*
D018942:Macrolides; D048630:Polyketide Synthases; D005990:Glycerol