title: Immunocytochemical localization of secretory component in Paneth cell secretory granules-rat Paneth cells participate in acquired immunity.
abstract: With the marker of Paneth cells-lysozyme, secretory component (SC) immunoreactivity was demonstrated exclusively in Paneth cells of rat small intestine. The other types of epithelial cells (columnar, goblet, endocrine) were negative. On electron microscopic level, many SC-positive colloidal gold particles were found in rough endoplasmic reticulum, Golgi complexes, basal membrane and secretory granules of Paneth cells. These results suggest that SC is not a component of ingested immune complex, but a membrane receptor on Paneth cell. It may function as receptor for polymeric IgA and mediate its transport across the mucosal epithelium. Thus, Paneth cells are responsible for SC synthesis and participate in IgA-mediated acquired immunity in rat small intestine.
authors.affiliation: Department of Nautical Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China.
authors.forename: Qing-Juan
authors.initials: QJ
authors.lastname: Tang
authors.forename: Kai-Zhong
authors.initials: KZ
authors.lastname: Tao
authors.lastname: Yun-Liu
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Sun
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Geng
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Jiang
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007150:Immunohistochemistry / Q000379:methods; D007421:Intestine, Small / Q000166:cytology / Q000378:metabolism; D019879:Paneth Cells / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012635:Secretory Component / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism*
chemical_list: D012635:Secretory Component