title: Postprandial lipemia in men with metabolic syndrome, hypertensives and healthy subjects.
abstract: BACKGROUND
  The metabolic syndrome (MetS), as well as postprandial hypertriglyceridemia, is associated with coronary heart disease. This study aimed to evaluate the postprandial lipemia after oral fat tolerance test (OFTT) in subjects with MetS and compare them to hypertensive (HTN) and healthy subjects.
  
  
  RESULTS
  OFTT was given to 33 men with MetS (defined by the Adult Treatment Panel III), 17 HTN and 14 healthy men. The MetS group was further divided according to fasting triglycerides (TG) into TG > or = 150 [MetS+TG, (n = 22)] or < 150 mg/dl [MetS-TG (n = 11)], and into those with or without hypertension [MetS+HTN (n = 24), MetS-HTN (n = 9), respectively]. TG concentrations were measured before and at 4, 6 and 8 h after OFTT and the postprandial response was quantified using the area under the curve (AUC) for TG. The postprandial response was significantly higher in MetS compared to HTN and healthy men [AUC (SD) in mg/dl/h; 2534 +/- 1016 vs. 1620 +/- 494 and 1019 +/- 280, respectively, p < or = 0.001]. The TG levels were increased significantly in MetS+TG compared to MetS-TG subjects at 4 (p = 0.022), 6 (p < 0.001) and 8 hours (p < 0.001). The TG were increased significantly in MetS-TG compared to healthy subjects at 4 (p = 0.011), 6 (p = 0.001) and 8 hours (p = 0.015). In linear regression analysis only fasting TG levels were a significant predictor of the AUC (Coefficient B = 8.462, p < 0.001).
  
  
  CONCLUSIONS
  Fasting TG concentration is the main determinant of postprandial lipemia. However, an exaggeration of TG postprandialy was found in normotriglyceridemic MetS and HTN compared to healthy subjects. This suggests that intervention to lower fasting TG levels should be recommended in MetS subjects.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Centre, Athens, Greece. genkolovou@mail.gr
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Anagnostopoulou
authors.forename: Antonis N
authors.initials: AN
authors.lastname: Pavlidis
authors.forename: Klelia D
authors.initials: KD
authors.lastname: Salpea
authors.forename: Stella A
authors.initials: SA
authors.lastname: Iraklianou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tsarpalis
authors.forename: Dimitris S
authors.initials: DS
authors.lastname: Damaskos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Manolis
authors.forename: Dennis V
authors.initials: DV
authors.lastname: Cokkinos
mesh_terms: D000328:Adult; D019540:Area Under Curve; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides