[Influence of corticotropin-releasing factor fragment CRF(4-6) on male rat sexual behaviour].
Centrally administered corticotrophin-releasing factor fragment CRF(4-6) (Pro-Pro-Ile) inhibits components of male rat sexual behaviour. Administration of 1 and 2 microg of tripeptide leads to dose-dependent increase in mount, intromission and ejaculation latencies. Alterations of sexual behaviour parameters suggest suppression of both sexual motivation and sexual performance.
Andreev-Andrievskiĭ
A A
AA
Tsvirkun
D V
DV
Makarenko
E Iu
EIu
Andreeva
L A
LA
Mart'ianov
A A
AA
D000818:Animals; D003307:Copulation / Q000187:drug effects* / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D012737:Sex Factors
D010446:Peptide Fragments; C488808:prolyl-prolylisoleucine; D003346:Corticotropin-Releasing Hormone