[Evaluation of antidepressant activity in a model of depressionlike state due to social isolation in rats].
The depression-like state was modeled in rats by means of restricted social experience in the early ontogenesis (growth under conditions of isolation since 17th day of life). This state is characterized with increased motor and exploratory activity, anxiety, depression, aggression, and hyperreactivity of reinforcement. This state can be considered as a syndrome of social isolation (isolant depression syndrome). The most pronounced and significant manifestations of the depression-like state due to social isolation were the increased levels of anxiety and aggression. A comparative study of three antidepressants with different mechanism of action (maprotiline, fluoxetine, tianeptine) on this model showed that tianeptine possessed the most pronounced antidepressant activity. This drug reduced the anxiety and aggression in isolants, which was probably related to serotonin-modulating activity of this drug.
Shabanov
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Roik
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D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004195:Disease Models, Animal; D004341:Drug Evaluation / Q000379:methods; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012934:Social Isolation / Q000523:psychology
D000928:Antidepressive Agents