title: Serotonergic mechanisms influence the response to glucocorticoid treatment in TMJ arthritis.
abstract: The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.
authors.affiliation: Department of Clinical Oral Physiology, Institute of Odontology, Karolinska Institute, Sweden. lars.fredriksson@ofa.ki.se
authors.forename: Lars
authors.initials: L
authors.lastname: Fredriksson
authors.forename: Per
authors.initials: P
authors.lastname: Alstergren
authors.forename: Sigvard
authors.initials: S
authors.lastname: Kopp
mesh_terms: D001168:Arthritis / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D017288:Pain Threshold / Q000187:drug effects; D012701:Serotonin / Q000097:blood*
chemical_list: D005938:Glucocorticoids; D012701:Serotonin; D008775:Methylprednisolone