title: Relationship of PCDD/F and Co-PCB concentrations in breast milk with infant birthweights in Tokyo, Japan.
abstract: OBJECTIVE
  To observe how PCDD/F and Co-PCB concentrations in breast milk relate to infant birthweights in Tokyo, Japan.
  
  
  METHODS
  Breast milk samples were collected from 240 mothers (aged 25-34years old) residing in Tokyo to measure the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs; 14 congeners), polychlorinated dibenzofurans (PCDFs; 15 congeners), and coplanar polychlorinated biphenyls (Co-PCBs; 12 congeners) in the breast milk fat. Individual milk samples (about 50ml) were obtained 30days after delivery, between the months of June and September in 1999 and 2000. The relationship of the infant birthweights with the PCDD/F and Co-PCB concentrations was observed.
  
  
  RESULTS
  The birthweights were negatively correlated the concentrations of many of the PCDD/F and Co-PCB congeners, with the mean toxic equivalent quantities (TEQs) of the Co-PCBs, and with the sum of the PCDD, PCDF and Co-PCBs, although their correlation coefficients were less than 0.200. Multiple regression analysis showed octachlorodioxin was statistically significant explanatory variate.
  
  
  CONCLUSIONS
  There were slight relationship between the dioxins levels of breast milk and the birthweights of the infants.
authors.affiliation: Department of Public Health, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan. tajimi@jichi.ac.jp
authors.forename: Morihiro
authors.initials: M
authors.lastname: Tajimi
authors.forename: Ritei
authors.initials: R
authors.lastname: Uehara
authors.forename: Makoto
authors.initials: M
authors.lastname: Watanabe
authors.forename: Izumi
authors.initials: I
authors.lastname: Oki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ojima
authors.forename: Yosikazu
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000493:pharmacokinetics* / Q000506:poisoning*; D001724:Birth Weight; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000493:pharmacokinetics* / Q000506:poisoning*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008895:Milk, Human / Q000737:chemistry*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000506:poisoning; D011247:Pregnancy; D012044:Regression Analysis; D012307:Risk Factors; D012989:Soil Pollutants / Q000493:pharmacokinetics* / Q000506:poisoning*
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants