title: Analysis of antibody response in goats to caprine herpesvirus 1.
abstract: Serum samples of goats experiencing natural and experimental infections and/or reactivation of caprine herpesvirus 1 (CpHV.1) were analysed with neutralization and Western blotting (WB) tests. WB immunological patterns resulted differently and related to neutralizing titers. In serum samples having neutralizing titer 1:2-1:4, antibodies to two proteins of Mw of 150 and 34 kDa were present. Antibodies against several proteins, two of those being characterized by monoclonal antibodies as gB and gC, were visualized by WB in sera having titer > or = 1:8. The neutralizing antibody titers and the pattern of antibody reactivity were hypothesized to modulate the reactivation and re-excretion process of CpHV.1.
authors.affiliation: Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, Strada provinciale per Casamassima km. 3, 70010 Valenzano, Italy. m.tempesta@veterinaria.uniba.it
authors.forename: Maria
authors.initials: M
authors.lastname: Tempesta
authors.forename: Grazia
authors.initials: G
authors.lastname: Greco
authors.forename: Elvira
authors.initials: E
authors.lastname: Tarsitano
authors.forename: Julien
authors.initials: J
authors.lastname: Thiry
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Etienne
authors.initials: E
authors.lastname: Thiry
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity / Q000276:immunology; D015511:Goat Diseases / Q000276:immunology* / Q000821:virology; D006041:Goats; D006566:Herpesviridae Infections / Q000276:immunology* / Q000662:veterinary*; D009500:Neutralization Tests; D018140:Varicellovirus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral