Histologic and clinical significance of atypical glandular cells on pap smears.
OBJECTIVE
To determine the association between atypical glandular cells (AGC) on Pap smear and clinically significant histology, in a large health region.


METHODS
A cytologic database of over one million Pap smears was reviewed for a result of AGUS/AGC. Cytologic and histologic follow up was obtained to establish the presence of significant histology.


RESULTS
456 patients available for follow up had AGUS/AGC cytology results (0.043% of all Pap smear results). 197(45.2%) patients had a clinically significant diagnosis including 40 with adenocarcinoma in situ (AIS) of the cervix and 48 with endometrial cancer.


CONCLUSIONS
AGC on a Pap smear is frequently associated with a clinically significant diagnosis.
Daniel
A
A
Department of Obstetrics and Gynecology, University of Alberta, Canada.
Barreth
D
D
Schepansky
A
A
Johnson
G
G
Capstick
V
V
Faught
W
W
D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D012189:Retrospective Studies; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology*