title: Deletion of the sigB gene in Bacillus cereus ATCC 14579 leads to hydrogen peroxide hyperresistance.
abstract: The sigB gene of Bacillus cereus ATCC 14579 encodes the alternative sigma factor sigma(B). Deletion of sigB in B. cereus leads to hyperresistance to hydrogen peroxide. The expression of katA, which encodes one of the catalases of B. cereus, is upregulated in the sigB deletion mutant, and this may contribute to the hydrogen peroxide-resistant phenotype.
authors.affiliation: Laboratory of Food Microbiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: van Schaik
authors.forename: Marcel H
authors.initials: MH
authors.lastname: Zwietering
authors.forename: Willem M
authors.initials: WM
authors.lastname: de Vos
authors.forename: Tjakko
authors.initials: T
authors.lastname: Abee
mesh_terms: D001409:Bacillus cereus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D012808:Sigma Factor / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D006861:Hydrogen Peroxide; D002374:Catalase; C090103:KATA protein, Bacillus subtilis