Fulminant hepatic failure associated with propylthiouracil: a case report with treatment emphasis on the use of plasmapheresis.
Propylthiouracil is a commonly used medication for hyperthyroidism. Though propylthiouracil-induced hepatotoxicity is a rarely encountered problem, death due to fulminant hepatic failure may occur. In the English literature, only 34 cases have been described with severe hepatotoxicity secondary to this drug. Here we report a case of fulminant hepatic failure due to propylthiouracil and review the issues of treatment and management with special emphasis on the use of plasmapheresis in such situations.
Aydemir
Selim
S
Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey. selimaydemir@hotmail.com
Ustundag
Yucel
Y
Bayraktaroglu
Taner
T
Tekin
Ishak Ozel
IO
Peksoy
Irfan
I
Unal
Aysun Uroglu
AU
D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000628:therapy*; D010956:Plasmapheresis; D011441:Propylthiouracil / Q000008:administration & dosage / Q000009:adverse effects*
D013956:Antithyroid Agents; D011441:Propylthiouracil