A highly potassium-selective ratiometric fluorescent indicator based on BODIPY azacrown ether excitable with visible light.
[structure: see text] A potassium-selective fluorescent BODIPY-linked azacrown ether chemosensor has been synthesized using novel substitution reactions of 3,5-dichloroBODIPY. The indicator absorbs and emits light in the visible wavelength range. The dissociation constant Kd for the complex between K+ and the probe is 0.5 mM in acetonitrile. Quantum chemical calculations show that the experimental hypsochromic shifts in absorption and fluorescence upon potassium binding are due to complexation, which induces a large conformational change of the sensor.
Baruah
Mukulesh
M
Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Qin
Wenwu
W
Vallée
Renaud A L
RA
Beljonne
David
D
Rohand
Taoufik
T
Dehaen
Wim
W
Boens
Noël
N
D001896:Boron Compounds / Q000737:chemistry*; D043844:Crown Ethers / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D008027:Light; D008958:Models, Molecular; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*
C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D043844:Crown Ethers; D005456:Fluorescent Dyes; D011188:Potassium