title: [The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma].
abstract: OBJECTIVE
  To investigate the effect of neoadjuvant chemotherapy on estrogen receptor (ER) and progesterone receptor (PR) expression in breast carcinoma.
  
  
  METHODS
  Samples were obtained from 31 patients with breast carcinoma who received neo-adjuvant chemotherapy, ER or PR expressions were analyzed in preoperative core biopsies and final surgical specimens.
  
  
  RESULTS
  ER level was up-regulated in 13 (41.9%) out of 31 cases, PR level was up-regulated in 10 (32.3%). Both ER level and PR level were up-regulated in 8 (25.8%) out of 31 cases.
  
  
  CONCLUSIONS
  Neoadjuvant chemotherapy may impact the hormone receptor status, ER and PR expression re-analysis in final surgical specimens is recommended.
authors.affiliation: Department of Breast, People's Hospital, Peking University, Beijing 100044, China. dr.wangshu@263.net
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Jia-qing
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Xin-min
authors.initials: XM
authors.lastname: Qiao
authors.forename: De-qi
authors.initials: DQ
authors.lastname: Yang
authors.forename: Fu-zhong
authors.initials: FZ
authors.lastname: Tong
authors.forename: Hong-jun
authors.initials: HJ
authors.lastname: Liu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D017024:Chemotherapy, Adjuvant; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D020360:Neoadjuvant Therapy; D017239:Paclitaxel / Q000008:administration & dosage; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015251:Epirubicin; D017239:Paclitaxel