NaBH4-InCl3-mediated one-pot chemo- and stereoselective decarboxylative reduction of alpha-aza gem-dicarboxylic esters to monoalcohols.
[reaction: see text] The combination of NaBH4 and a catalytic amount of InCl3 provides a one-pot method for chemo- and stereoselective decarboxylative reduction of gem-dicarboxylic esters 1 to monoalcohols 2 in the presence of the lactam carbonyl in refluxing acetonitrile under inert atmosphere.
Haldar
Pranab
P
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
Ray
Jayanta K
JK