title: Recognition of guanines at a double helix-coil junction in DNA by a trinuclear copper complex.
abstract: Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix-coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, 20742, USA.
authors.forename: Takeo
authors.initials: T
authors.lastname: Ito
authors.forename: Sunita
authors.initials: S
authors.lastname: Thyagarajan
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Karlin
authors.forename: Steven E
authors.initials: SE
authors.lastname: Rokita
mesh_terms: D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D009942:Organometallic Compounds; D006147:Guanine; D003300:Copper; D004247:DNA