Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides.
Several novel 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-(N-aryl) carboxamides were prepared by reaction of pyridoxal hydrochloride with various N-arylcyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5-25microg/mL), displaying comparable or even better efficacy than the standard drugs.
Zhuravel'
Irina O
IO
National Pharmaceutical University, Kharkiv, Ukraine.
Kovalenko
Sergiy M
SM
Ivachtchenko
Alexandre V
AV
Balakin
Konstantin V
KV
Kazmirchuk
Victor V
VV
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011725:Pyridines; D002939:Ciprofloxacin; D015725:Fluconazole