Determination of mutation trend in proteins by means of translation probability between RNA codes and mutated amino acids.
In this study, we estimate the translation probability to amino acid from RNA codon. With the determined 183 translation probabilities and amino-acid composition of eight highly mutated proteins, we construct the theoretical distributions of mutated amino acids in these proteins and then compare them with their actual distributions affected by mutations. Thereafter we trace the pattern of translation probabilities from RNA codons to mutated amino acids of 1053 point missense mutations. Finally, we statistically conclude that the natural mutation trend goes along the theoretical translation probability.
Wu
Guang
G
Computational Mutation Project, DreamSciTech Consulting, 301, Building 12, Nanyou A-zone, Shenzhen, Guangdong Province CN, China. hongguanglishibahao@yahoo.com
Yan
Shaomin
S
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000235:genetics*; D003062:Codon; D008969:Molecular Sequence Data; D009154:Mutation; D011336:Probability; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000235:genetics*
D000596:Amino Acids; D003062:Codon; D011506:Proteins; D012313:RNA