[Effects of the platelet activating factor on the proliferation and IgE secretion by U-266BL human myeloma cells].
Platelet activating factor (PAF) influences the proliferation and IgE secretion by U-266BL human myeloma (HM) cells. At a relatively high PAF concentration (up to 10(-8) M), the rate of proliferation is significantly decreased, while the IgE secretion rate is increased. At low PAF concentrations (10(-11) M), the HM cell proliferation rate increases, whereas their ability to IgE secretion decreases. The specific secretion activity (per cell) is a linear function in the range of PAF concentrations from 10(-11) to 10(-8) M. This behavior can be used for the quantitative determination of PAF in biological media.
Krasheninnikov
M E
ME
Pliashkevich
Iu G
IuG
D001681:Biological Assay / Q000379:methods; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D010972:Platelet Activating Factor / Q000032:analysis / Q000494:pharmacology*
D010972:Platelet Activating Factor; D007073:Immunoglobulin E