title: Production of Ac-225 from Th-229 for targeted alpha therapy.
abstract: This work describes a method for the separation and purification of Ac-225 from a Th-229 source. The procedure is based on the combination of ion exchange and extraction chromatographic methods in nitric acid media and allows the preparation of carrier-free, clinical grade Ac-225 with an overall yield exceeding 95%. Quality control of the product is performed using radiometric (alpha, gamma spectrometry) and mass spectrometric methods. The Ac-225 product can be loaded on a radionuclide generator for the preparation of Bi-213 for preclinical and clinical studies of targeted alpha therapy of cancer and infectious diseases.
authors.affiliation: European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Apostolidis
authors.forename: R
authors.initials: R
authors.lastname: Molinet
authors.forename: G
authors.initials: G
authors.lastname: Rasmussen
authors.forename: A
authors.initials: A
authors.lastname: Morgenstern
mesh_terms: D000186:Actinium / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use*; D000838:Anions / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry; D013793:Thallium / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D000838:Anions; D011868:Radioisotopes; D013793:Thallium; D000186:Actinium