[The role of macrophages in pathogenesis of limited inflammation].
It is shown on 250 male rats that a limiting capsule around an inflammation focus develops in the presence of bacteria as well as intoxication and possibility of infection generalization. Macrophages (Mph) phagocyte necrotic tissue in aceptic inflammation and stimulate reparation with formation of a scar. The role of Mph is more complicated in modeling of soft tissue abscess: they phagocyte bacteria inducing immune system involvement into the inflammatory process, stimulate primary cooperation of cells which produce inflammatory tissue mediators, regeneratory processes with final formation of a connective tissue capsule around a focus of purulent inflammation. When the system of phagocyting mononuclear cells is stimulated, all processes in the zone of inflammation become activated; when this system is inhibited the processes slow down.
Paukov
V S
VS
Daabul'
S A
SA
Belaieva
N Iu
NIu
D000038:Abscess / Q000276:immunology* / Q000473:pathology; D000818:Animals; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D010587:Phagocytosis; D051381:Rats