Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis.
A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1-4). The structures of compounds 1-4 were elucidated by interpretation of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.
Sata
Noriko
N
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
Abinsay
Hazel
H
Yoshida
Wesley Y
WY
Horgen
F David
FD
Sitachitta
Namthip
N
Kelly
Michelle
M
Scheuer
Paul J
PJ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006254:Hawaii; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047229:Plakortis / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011753:Pyrones