Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.
We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.
Dawson
M A
MA
Haematology Department, The Alfred, Melbourne, Victoria, Australia. dawsonm@ausdoctors.net
Davis
A
A
Elliott
P
P
Cole-Sinclair
M
M
D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002701:Chloramphenicol / Q000009:adverse effects / Q000627:therapeutic use; D004920:Erythropoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D011500:Protein Synthesis Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000187:drug effects / Q000473:pathology; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology
D000081:Acetamides; D006454:Hemoglobins; D023303:Oxazolidinones; D011500:Protein Synthesis Inhibitors; D002701:Chloramphenicol; D000069349:Linezolid