title: Successful treatment with voriconazole of fungal cerebral abscess due to Cladophialophora bantiana.
abstract: We report the first successfully treated case of Cladophialophora bantiana cerebral abscess with the relatively new antifungal agent voriconazole. Infection with this organism is often fatal. A 64-year-old man presented to our institution with progressive neurologic symptoms due to a brain abscess. A stereotactic brain biopsy confirmed the pathogen as C. bantiana. We discuss the successful treatment of this patient, and review the pharmacological actions of voriconazole and the literature on the treatment of this organism. Previously considered a rare cause of cerebral abscess, C. bantiana fungal infections have become more common in recent years. Aggressive and continuous treatment with voriconazole may offer an improved chance of survival in these patients.
authors.affiliation: Department of Neurological Surgery, Mayo Clinic Scottsdale, Mayo Clinic College of Medicine, 13600 East Shea Boulevard, Scottsdale, AZ 85259, USA. lyons.mark2@mayo.edu
authors.forename: Mark K
authors.initials: MK
authors.lastname: Lyons
authors.forename: Janis E
authors.initials: JE
authors.lastname: Blair
authors.forename: Kevin O
authors.initials: KO
authors.lastname: Leslie
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy*; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis / Q000188:drug therapy*; D002963:Cladosporium / Q000145:classification; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole