title: Optical resolution by crystallization from melt using enantiomer derivatives as resolving agents: nonlinear behavior of resolving agent mixtures.
abstract: Substituted racemic 1-phenylethylamine derivatives were reacted in molten phase with chiral N-substituted 1-phenylethylamine dicarboxylic acid derivatives (4-9), and their mixtures (e.g., 4+6, 7+8, etc.) in different ratios, and the crystalline quasi-racemic diastereomers so formed were separated. Nonlinear behavior of the mixtures of resolving agents having related structure and considerable positive and negative chiral-chiral interactions were observed.
authors.affiliation: Research Group for Organic Chemical Technology, Budapest University of Technology and Economics, Hungary. jschindler@mail.bme.hu
authors.forename: József
authors.initials: J
authors.lastname: Schindler
authors.forename: Márton
authors.initials: M
authors.lastname: Egressy
authors.forename: József
authors.initials: J
authors.lastname: Bálint
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hell
authors.forename: Elemér
authors.initials: E
authors.lastname: Fogassy