[A vasoactive peptide: urotensin II].
Urotensin II (U II ) is currently the most potent vasoconstrictor. G-protein coupled receptor 14 ( GPR-14) is its specific receptor. This review mainly discribes the structure and distribution of U II and GPR14, the activities that U II and GPR14 stimulates proliferation of vascular smooth muscle cells and vasoconstriction, as well as its mechanism.
Liu
Guo-Qiang
GQ
Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zeng
Zheng-Pei
ZP
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D014579:Urotensins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D043562:Receptors, G-Protein-Coupled; C121697:UTS2R protein, human; D014579:Urotensins; D014662:Vasoconstrictor Agents; C029677:urotensin II