title: Two cases of endometrial cancer diagnosis associated with bone metastasis.
abstract: BACKGROUND
  Endometrial adenocarcinoma is commonly seen in postmenopausal women and uterine bleeding is the first sign in 90% of the cases. Bone metastasis as the presenting feature is extremely rare. We report two endometrial cancer patients with metastasis to the tibia and cervical vertebra at the time of primary disease.
  
  
  METHODS
  Two patients were diagnosed with stage IVB endometrial cancer with involvement of the tibia and cervical column, respectively. The first case was treated with 8 cycles of platinum, doxorubicin, and cyclophosphamide, but she died 3 months after the completion of chemotherapy as a result of progressive disease. The second case received surgery followed by chemotherapy with cisplatin and doxorubicin, but she died 2 months later.
  
  
  CONCLUSIONS
  These cases highlight the rare and unusual presentation of endometrial cancer. For this reason a review of the literature is also provided for all cases with evidence of bone metastasis at presentation of the disease, and as a recurrence.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bari, Italy. vloizzi@tiscali.it
authors.forename: Vera
authors.initials: V
authors.lastname: Loizzi
authors.forename: Gennaro
authors.initials: G
authors.lastname: Cormio
authors.forename: Annarita
authors.initials: A
authors.lastname: Cuccovillo
authors.forename: Nicola
authors.initials: N
authors.lastname: Fattizzi
authors.forename: Luigi
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D002574:Cervical Vertebrae; D003520:Cyclophosphamide / Q000008:administration & dosage; D004164:Diphosphonates / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D008875:Middle Aged; D010984:Platinum / Q000008:administration & dosage; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D013977:Tibia; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D010984:Platinum; D000077211:Zoledronic Acid; D004317:Doxorubicin; D003520:Cyclophosphamide