Small peptides as modular catalysts for the direct asymmetric aldol reaction: ancient peptides with aldolase enzyme activity.
Simple peptides and their analogues having a primary amino group as the catalytic residue mediate the direct asymmetric intermolecular aldol reaction with high stereoselectivity and furnish the corresponding aldol products with up to 99% ee; this intrinsic ability of highly modular peptides may explain the initial molecular evolution of aldolase enzymes.
Zou
Weibiao
W
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Ibrahem
Ismail
I
Dziedzic
Pawel
P
Sundén
Henrik
H
Córdova
Armando
A
D002384:Catalysis; D019143:Evolution, Molecular; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D013237:Stereoisomerism
D010455:Peptides; D005634:Fructose-Bisphosphate Aldolase