title: Iron overload and chelation.
abstract: Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication. Despite the abundance of iron in nature, the solubility of its stable ferric form is extremely low. Hence, living organisms were compelled to develop efficient mechanisms for iron transport and storage.
authors.affiliation: Department of Hematology, Shaare Zedek Medical Center, Israel. hershko@szmc.org.il
authors.forename: Chaim
authors.initials: C
authors.lastname: Hershko
authors.forename: Gabriela
authors.initials: G
authors.lastname: Link
authors.forename: Abraham M
authors.initials: AM
authors.lastname: Konijn
authors.forename: Z
authors.initials: Z
authors.lastname: Ioav Cabantchik
mesh_terms: D015913:Chelation Therapy / Q000379:methods*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use; D019190:Iron Overload / Q000209:etiology / Q000628:therapy*; D017262:Siderophores / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D007502:Iron Chelating Agents; D017262:Siderophores