title: Intravascular large T-cell lymphoma: a case report of CD30-positive and ALK-negative anaplastic type with cytotoxic molecule expression.
abstract: We reported a case of intravascular T-cell lymphoma (T-IVL) with anaplastic large cell morphology, the hemophagocytic syndrome, and an aggressive clinical course. Phenotypic analysis of the tumor cells revealed CD2+, CD3-, CD4+, CD5-, CD8-, CD30+, CD56-, T-cell receptor alpha/beta-, ALK-, TIA1+, granzyme B+, and perforin+. No association with Epstein-Barr virus was found by in situ hybridization. A review revealed that 25 cases of T-IVL have been reported in the available literature, only two of which were of CD30+ anaplastic large cell or cytotoxic T-cell type. The findings in the present case may highlight the unique clinicopathologic aspects of a subset of CD30-positive T-IVLs with an ALK-negative cytotoxic phenotype.
authors.affiliation: Department of Pathology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. etakahashi@aichi-cc.jp
authors.forename: Emiko
authors.initials: E
authors.lastname: Takahashi
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kajimoto
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Fukatsu
authors.forename: Megumi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Eimoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism*; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D017730:Ki-1 Antigen / Q000378:metabolism*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000473:pathology*; D008297:Male
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen; D000469:Alkaline Phosphatase