Cure of multidrug-resistant Acinetobacter baumannii fixation device-related orthopedic infections in two patients with intravenous colistin.
We report our experience with two cases of fixation device-related orthopedic infections due to multidrug-resistant Acinetobacter baumannii strains. Both patients were successfully treated with intravenous administration of colistin, despite the reported poor penetration of this medication to these tissues, in the old literature. No serious colistin-associated toxicity developed and no recurrence of the infection occurred on follow up.
Kasiakou
Sofia K
SK
Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
Fragoulis
Kostas
K
Tzagarakis
George
G
Mistidis
Panagiotis
P
Kapaskelis
Anastasios
A
Falagas
Matthew E
ME
D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000328:Adult; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects
D003091:Colistin