[The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum].
OBJECTIVE
To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.


METHODS
Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.


RESULTS
The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).


CONCLUSIONS
HPCD is an ideal solubilizer for paeonolum.
Jian
Ling-Yan
LY
The Second Hospital, China Medical University, Shenyang 110004, China.
Yang
Yue-Hui
YH
Xu
Ying-Hong
YH
He
Zhong-Gui
ZG
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000098:Acetophenones / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D004355:Drug Stability; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D047392:beta-Cyclodextrins
D000098:Acetophenones; D005079:Excipients; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C013638:paeonol