Solvent-dehydrated cadaveric dermis: a new allograft for pubovaginal sling surgery.
OBJECTIVE
The aim of this study was to evaluate the efficacy of solvent-dehydrated cadaveric dermis in pubovaginal sling surgery for the first time in the literature.


METHODS
Twenty-five women with stress urinary incontinence underwent pubovaginal sling surgery using 2 x 12 cm allograft dermis. Preoperatively, all patients were evaluated by a detailed urogynecologic evaluation, voiding diary, pelvic examination and urodynamic investigation. Outcome was assessed by the Urogenital Distress Inventory short form and standardized follow-up questionnaires.


RESULTS
Twenty (80%) patients were cured of stress incontinence symptoms. Seventeen wore no pad and three reported occasional stress urinary incontinence and used no or one pad at a mean follow up of 12 months. Five (20%) patients in our series experienced the same amount of leakage as before the surgery. Seventy-six percent of the patients indicated that urinary incontinence was no longer negatively affecting their daily life and were satisfied with the procedure.


CONCLUSIONS
Questionnaire-based assessment of outcome suggests that solvent-dehydrated cadaveric dermis is effective in the treatment of stress urinary incontinence. However, larger and comparative prospective studies with long-term results and randomized comparison of tissue preparation techniques are warranted.
Onur
Rahmi
R
Department of Urology, Firat University Faculty of Medicine, Elazig, Turkey. rahmionur@yahoo.com
Singla
Ajay
A
D000328:Adult; D000368:Aged; D002102:Cadaver; D003890:Desiccation; D005260:Female; D006801:Humans; D008875:Middle Aged; D016038:Skin Transplantation; D012997:Solvents; D011795:Surveys and Questionnaires; D020858:Tissue and Organ Harvesting / Q000379:methods; D014550:Urinary Incontinence, Stress / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000379:methods
D012997:Solvents