title: No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.
abstract: OBJECTIVE
  We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population.
  
  
  METHODS
  These polymorphisms were analysed by polymerase chain reaction-restriction fragment length polymorphism in patients with chronic heart failure due to idiopathic dilated cardiomyopathy (DCM) and compared with the control group.
  
  
  RESULTS
  There were no differences or any trends in the allele and genotype frequencies of the beta(1)Ser49Gly and beta(1)Arg389Gly polymorphisms. The allele frequency of the alpha(2c)Del322-325 variant was lower in patients than in controls (0.11 vs. 0.04, P = 0.011 < 0.017, by Bonferroni correction), while the genotype frequency just failed to reach significance (P = 0.022 > 0.017, by Bonferroni correction).
  
  
  CONCLUSIONS
  In this population, the variants beta(1)Ser49, beta(1)Arg389, and alpha(2c)Del322-325 do not appear to be risk factors for chronic heart failure due to DCM. The alpha(2c)Del322-325 variant may in fact confer some protection.
authors.affiliation: Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
authors.forename: Shinpei
authors.initials: S
authors.lastname: Nonen
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okamoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Akino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Matsui
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujio
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
authors.forename: Akira
authors.initials: A
authors.lastname: Kitabatake
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018341:Receptors, Adrenergic, alpha-2; D018342:Receptors, Adrenergic, beta-1