Basics of the virology of HIV-1 and its replication.
Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The understanding of HIV-1 pathogenesis is essential to develop and maintain antiretroviral treatment and vaccination. Since the first isolation of HIV-1 in cell culture, thousands of publications dealing with HIV and/or AIDS per year were released. In this review we give a basic overview of the virology of HIV-1 including the functions of the different HIV-1 proteins required for effective viral replication. Moreover, we summarize the interactive processes between HIV-1 and its target cells. Finally, the HIV-1 specific immune response and the current status of antiretroviral therapy are briefly described in this review.
Sierra
Saleta
S
Institute of Virology, University of Cologne, Fürst-Pückler Str. 56, D-50935 Cologne, Germany.
Kupfer
Bernd
B
Kaiser
Rolf
R
D019380:Anti-HIV Agents / Q000494:pharmacology; D000917:Antibody Formation; D016679:Genome, Viral; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D008285:Major Histocompatibility Complex / Q000235:genetics; D011110:Polymorphism, Genetic; D011991:Receptors, Virus / Q000235:genetics; D017735:Virus Latency; D014779:Virus Replication
D019380:Anti-HIV Agents; D011991:Receptors, Virus