title: Endocrine tumours of the gastrointestinal tract. Somatostatin receptors as tools for diagnosis and therapy: molecular aspects.
abstract: Somatostatin is a neuropeptide that acts as an endogenous inhibitor of various cellular functions including endocrine and exocrine secretions and the proliferation of normal and tumour cells. Its action is mediated by a family of G-protein-coupled receptors (sst1-sst5) that are widely distributed in normal and tumour cells. Gastroenteropancreatic endocrine tumours express multiple somatostatin receptors, sst2 being clearly predominant. These receptors represent the molecular basis for the clinical use of somatostatin analogues in the treatment of endocrine tumours and their in vivo localisation. This review covers current knowledge in somatostatin receptor biology and signalling.
authors.affiliation: IFR31, Institut Louis Bugnard, BP 84225, INSERM U531, Toulouse, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Guillermet-Guibert
authors.forename: Hicham
authors.initials: H
authors.lastname: Lahlou
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pyronnet
authors.forename: Corinne
authors.initials: C
authors.lastname: Bousquet
authors.forename: Christiane
authors.initials: C
authors.lastname: Susini
mesh_terms: D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007205:Indium Radioisotopes; D048370:MAP Kinase Kinase 2 / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D017481:Receptors, Somatostatin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013004:Somatostatin / Q000031:analogs & derivatives; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D042461:Vascular Endothelial Growth Factor A; D013004:Somatostatin; D048370:MAP Kinase Kinase 2; C081788:pentetreotide