[Calcium channel blockers and bone metabolism].
The effects of calcium channel blockers have been studied on calcitropic hormones and cells involved in bone turnover, osteoblasts and osteoclasts. The secretion of parathyroid hormone is affected by calcium channel blockers, but the modes of action seem to depend upon the species of calcium channel blockers. Generally, overall effects of calcium channel blockers on bone metabolisms and bone mineral density should be trivial and the adverse side effects in this field must be negate. Recent development of a new analogue which may act on the calcium channel of osteoblasts and enhance the differentiation of these cells is intriguing.
Hosoi
Takayuki
T
Department of Advanced Medicine, National Center for Geriatrics and Gerontology.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*
D002121:Calcium Channel Blockers