Monoamine oxidase a polymorphism in Brazilian patients: risk factor for late-onset Alzheimer's disease?
Different studies have attempted to find polymorphisms involved in the serotonergic pathway that could be involved in mood disorders and late-onset Alzheimer's disease (LOAD) symptoms. Here, we compared the frequency of two polymorphisms: monoamine oxidase A (MAOA) and serotonin transporter in LOAD patients versus controls. No evidence of association was observed when these polymorphisms were compared separately; however, the combination of the MAOA allele 1+the short allele of 5-HTTLPR+ApoE-epsilon4 was significantly more frequent in patients than in controls. It reinforces the hypothesis that different genes acting together might play a role in AD susceptibility. Based on these data, we suggest replicating these studies in larger samples of LOAD patients belonging to different ethnic groups.
Nishimura
Agnes L
AL
Human Genome Research Center, Biology Department, Institute of Biosciences, São Paulo University (IBUSP), São Paulo, Brazil.
Guindalini
Camila
C
Oliveira
João R M
JR
Nitrini
Ricardo
R
Bahia
Valéria S
VS
de Brito-Marques
Paulo R
PR
Otto
Paulo A
PA
Zatz
Mayana
M
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics; D001938:Brazil; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics
D001057:Apolipoproteins E; D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase