title: Arabidopsis H+-PPase AVP1 regulates auxin-mediated organ development.
abstract: The transport of auxin controls developmental events in plants. Here, we report that in addition to maintaining vacuolar pH, the H+-pyrophosphatase, AVP1, controls auxin transport and consequently auxin-dependent development. AVP1 overexpression results in increased cell division at the onset of organ formation, hyperplasia, and increased auxin transport. In contrast, avp1-1 null mutants have severely disrupted root and shoot development and reduced auxin transport. Changes in the expression of AVP1 affect the distribution and abundance of the P-adenosine triphosphatase and Pinformed 1 auxin efflux facilitator, two proteins implicated in auxin distribution. Thus, AVP1 facilitates the auxin fluxes that regulate organogenesis.
authors.affiliation: Department of Plant Science, University of Connecticut, Storrs, CT 06268, USA.
authors.forename: Jisheng
authors.initials: J
authors.lastname: Li
authors.forename: Haibing
authors.initials: H
authors.lastname: Yang
authors.forename: Wendy Ann
authors.initials: WA
authors.lastname: Peer
authors.forename: Gregory
authors.initials: G
authors.lastname: Richter
authors.forename: Joshua
authors.initials: J
authors.lastname: Blakeslee
authors.forename: Anindita
authors.initials: A
authors.lastname: Bandyopadhyay
authors.forename: Boosaree
authors.initials: B
authors.lastname: Titapiwantakun
authors.forename: Soledad
authors.initials: S
authors.lastname: Undurraga
authors.forename: Mariya
authors.initials: M
authors.lastname: Khodakovskaya
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Richards
authors.forename: Beth
authors.initials: B
authors.lastname: Krizek
authors.forename: Angus S
authors.initials: AS
authors.lastname: Murphy
authors.forename: Simon
authors.initials: S
authors.lastname: Gilroy
authors.forename: Roberto
authors.initials: R
authors.lastname: Gaxiola
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D017360:Arabidopsis / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism; D001692:Biological Transport; D002452:Cell Count; D049109:Cell Proliferation; D048430:Cell Shape; D002473:Cell Wall / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D017403:In Situ Hybridization; D007210:Indoleacetic Acids / Q000378:metabolism* / Q000494:pharmacology; D043564:Inorganic Pyrophosphatase / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D018519:Meristem / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D009154:Mutation; D018515:Plant Leaves / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D018517:Plant Roots / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D017494:Proton Pumps / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D015398:Signal Transduction; D014170:Transformation, Genetic
chemical_list: D029681:Arabidopsis Proteins; D007210:Indoleacetic Acids; D026901:Membrane Transport Proteins; C116363:PIN1 protein, Arabidopsis; D017494:Proton Pumps; C030737:indoleacetic acid; D000251:Adenosine Triphosphatases; C505048:AVP1 protein, Arabidopsis; D043564:Inorganic Pyrophosphatase