title: [Effect of tamoxifen in lipids of diabetic rats induced by streptozotocin].
abstract: OBJECTIVE
  To evaluate the effect of tamoxifen in the lipidic and renal profile in diabetic and control rats.
  
  
  METHODS
  40 female Wistar rats had been used (180-220g corporal weight), divided randomly in 4 groups: C (n = 10, received vehicle), T (n = 10, treated with tamoxifen, 0.3mg/kg/day), D (n = 10, diabetic induced by streptozotocin, 45mg/Kg) and DT (n = 10, diabetic treated with tamoxifen). Glucose, total cholesterol, triglyceride, total proteins, albumin, urea and creatinin were analyzed using Labtest Kits through the Cobas Mira analyzer (Germany, 1996).
  
  
  RESULTS
  Group T presented a reduction of total cholesterol and triglyceride in relation to C, and group D an increase in relation to the other ones. About the total proteins it was observed an increasing in Group T in relation to C. The albumin diminished in groups D and DT in relation to C and T. The urea levels increased in groups D and DT in relation to C and T.
  
  
  CONCLUSIONS
  In relation to the lipidic profile it was evidenced that during the period of 60 days the treatment with tamoxifen promoted a reduction in cholesterol and triglyceride levels in the serum, even associated to the condition of Diabetes mellitus.
authors.affiliation: Farmacêutico Bioquímica Graduado pela UFRN, Natal - RN, Brasil.
authors.forename: Francisco C
authors.initials: FC
authors.lastname: Nogueira Júnior
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Coelho
authors.forename: Maria Margareth C
authors.initials: MM
authors.lastname: Almeida
authors.forename: Teresa Cristina P
authors.initials: TC
authors.lastname: Silva
authors.forename: Elaine Cristina S
authors.initials: EC
authors.lastname: Ferreira
authors.forename: Ulisvaldo Bruno O
authors.initials: UB
authors.lastname: Macedo
authors.forename: Francisco Paulo F
authors.initials: FP
authors.lastname: Neto
authors.forename: José
authors.initials: J
authors.lastname: Brandão Neto
authors.forename: Maria das Graças
authors.initials: Md
authors.lastname: Almeida
authors.forename: Adriana Augusto
authors.initials: AA
authors.lastname: de Rezende
mesh_terms: D000418:Albumins / Q000032:analysis; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects*; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013629:Tamoxifen / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*; D014508:Urea / Q000097:blood
chemical_list: D000418:Albumins; D004965:Estrogen Antagonists; D011506:Proteins; D014280:Triglycerides; D013629:Tamoxifen; D013311:Streptozocin; D014508:Urea; D002784:Cholesterol; D003404:Creatinine