title: Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
abstract: The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).
authors.affiliation: UCB Celltech, Granta Park, Great Abington, Cambridge, CB1 6GS, UK.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Birch
authors.forename: George M
authors.initials: GM
authors.lastname: Buckley
authors.forename: Natasha
authors.initials: N
authors.lastname: Davies
authors.forename: Hazel J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Frost
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Gilbert
authors.forename: Duncan R
authors.initials: DR
authors.lastname: Hannah
authors.forename: Alan F
authors.initials: AF
authors.lastname: Haughan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Madigan
authors.forename: Trevor
authors.initials: T
authors.lastname: Morgan
authors.forename: William R
authors.initials: WR
authors.lastname: Pitt
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ratcliffe
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Ray
authors.forename: Marianna D
authors.initials: MD
authors.lastname: Richard
authors.forename: Andrew
authors.initials: A
authors.lastname: Sharpe
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Taylor
authors.forename: Justine M
authors.initials: JM
authors.lastname: Whitworth
authors.forename: Sophie C
authors.initials: SC
authors.lastname: Williams
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D008968:Molecular Conformation; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011799:Quinazolines; D007168:IMP Dehydrogenase; C501687:IMPDH2 protein, human