title: Calcinosis cutis with siliconomas complicated by hypercalcemia.
abstract: OBJECTIVE
  To report a case of extensive calcinosis cutis presumably caused by silicone injections, which was complicated by hypercalcemia.
  
  
  METHODS
  A long-standing case of calcinosis cutis with subsequent development of hypercalcemia is presented, and possible mechanisms for the underlying metabolic dysfunction are discussed.
  
  
  RESULTS
  A 78-year-old woman presented with severe hypercalcemia and was found to have extensive subcutaneous calcifications on the anterior chest wall and abdomen, likely related to previous silicone injections. The hypercalcemia was treated with intravenously administered pamidronate and aggressive rehydration. Resection of the extensive long-standing calcific deposits was not a viable option. The hypercalcemia resolved with treatment, but the patient died of urinary tract sepsis.
  
  
  CONCLUSIONS
  Extensive calcinosis cutis can result in hypercalcemia, possibly attributable to granulomatous reaction and vitamin D excess.
authors.affiliation: Department of Endocrinology, Tan Tock Seng Hospital, Singapore.
authors.forename: Seng Cheong
authors.initials: SC
authors.lastname: Loke
authors.forename: Melvin Khee-Shing
authors.initials: MK
authors.lastname: Leow
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002114:Calcinosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002118:Calcium / Q000097:blood; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D015745:Granuloma, Foreign-Body / Q000150:complications* / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007279:Injections, Subcutaneous; D000077268:Pamidronate; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014807:Vitamin D / Q000502:physiology
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D012828:Silicones; D014807:Vitamin D; D000077268:Pamidronate; D002118:Calcium