title: Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.
abstract: A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%).
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Lund University, University Hospital, 205 02 Malmö, Sweden.
authors.forename: Caroline
authors.initials: C
authors.lastname: Holm
authors.forename: Ingrid
authors.initials: I
authors.lastname: Ora
authors.forename: Cecilia
authors.initials: C
authors.lastname: Brunhoff
authors.forename: Lola
authors.initials: L
authors.lastname: Anagnostaki
authors.forename: Göran
authors.initials: G
authors.lastname: Landberg
authors.forename: Jenny Liao
authors.initials: JL
authors.lastname: Persson
mesh_terms: D000293:Adolescent; D000367:Age Factors; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D019925:Cyclin A / Q000096:biosynthesis*; D056750:Cyclin A1; D018572:Disease-Free Survival; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007223:Infant; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor; C503745:CCNA1 protein, human; D019925:Cyclin A; D056750:Cyclin A1; D009363:Neoplasm Proteins