Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample.
BACKGROUND
Linkage studies have confirmed that chromosome 1q23.3 is a susceptibility locus for schizophrenia. It was then claimed that markers at the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON) gene showed allelic association with schizophrenia in Canadian families. A second Chinese study found a base pair polymorphism at the CAPON gene also associated with schizophrenia.


METHODS
We attempted replication using eight markers from the Canadian study in a UK based sample of 450 cases and 450 supernormal controls.


RESULTS
We found no evidence for allelic or haplotypic association with schizophrenia for any of the markers found to be associated in the Canadian sample.


CONCLUSIONS
The negative results might reflect genetic heterogeneity between the Canadian, Chinese and UK samples or be due to methodological problems. The present finding weakens the evidence that mutations or variation in the CAPON gene are causing genetic susceptibility to schizophrenia in European populations.
Puri
Vinay
V
Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Royal Free and University College London Medical School, Windeyer Institute of Medical Sciences, London, W1T 4JF, UK.
McQuillin
Andrew
A
Thirumalai
Srinivasa
S
Lawrence
Jacob
J
Krasucki
Robert
R
Choudhury
Khalid
K
Datta
Susmita
S
Kerwin
Simon
S
Quested
Digby
D
Bass
Nicholas
N
Pimm
Jonathan
J
Lamb
Graham
G
Moorey
Helen
H
Kandasami
Gomathinayagam
G
Badacsonyi
Allison
A
Kelly
Katie
K
Morgan
Jenny
J
Punukollu
Bhaskar
B
Nadeem
Haitham
H
Curtis
David
D
Gurling
Hugh M D
HM
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D002878:Chromosomes, Human, Pair 1; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D006113:United Kingdom
D048868:Adaptor Proteins, Signal Transducing; C488081:NOS1AP protein, human