title: [Porcine submucosa graft for the treatment of duodenal injuries in dogs].
abstract: OBJECTIVE
  To evaluate the biocompatibility and effectiveness of porcine SIS (small intestinal submucosa), when used as a patch to repair a defect on the anterior duodenal wall.
  
  
  METHODS
  The experimental study was performed in 8 dogs. A segment of the anterior duodenal wall was removed and the defect was repaired with a patch of porcine intestinal submucosa. On the 120th post operative day the animals were sacrificed and the segment of duodenum containing the patch was removed to a macroscopic and microscopic evaluation.
  
  
  RESULTS
  There was no infection, suture dehiscence or fistula. The microscopic evaluation showed complete re-epithelization in 75% of the cases, with moderate fibroblastic proliferation in 87.5% of the cases.
  
  
  CONCLUSIONS
  The porcine SIS used as a patch acts as a tissue substitute for repairing induced lesions in duodenal wall of dogs.
authors.affiliation: Programa de Pós Graduação em Clínica Cirúrgica, Pontifícia Universidade Católica do Paraná. z.alves@pucpr.br
authors.forename: Zacarias Alves de
authors.initials: ZA
authors.lastname: Souza Filho
authors.forename: Fernando Hintz
authors.initials: FH
authors.lastname: Greca
authors.forename: Sergio Luiz
authors.initials: SL
authors.lastname: Rocha
authors.forename: Sergio Ossamu
authors.initials: SO
authors.lastname: Ioshii
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Domanski
authors.forename: Diogo
authors.initials: D
authors.lastname: Kfouri
authors.forename: Priscila Dall Prá
authors.initials: PD
authors.lastname: Campos
authors.forename: Ruy Fernando Kuenzer Caetano da
authors.initials: RF
authors.lastname: Silva
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004386:Duodenum / Q000293:injuries* / Q000473:pathology; D006648:Histocompatibility; D007413:Intestinal Mucosa / Q000637:transplantation*; D013552:Swine; D014183:Transplantation, Heterologous