Di-tert-butylsilylene-directed alpha-selective synthesis of 4-methylumbelliferyl T-antigen.
[reaction: see text] We have succeeded in the facile synthesis of 4-methylumbelliferyl T-antigen as a substrate for endo-alpha-N-acetylgalactosaminidase by exploiting the combination of the di-tert-butylsilylene effect and the Mitsunobu reaction.
Imamura
Akihiro
A
Department of Applied Bioorganic Chemistry, Gifu University, Gifu 501-1193, Japan.
Ando
Hiromune
H
Ishida
Hideharu
H
Kiso
Makoto
M
D000957:Antigens, Viral, Tumor / Q000737:chemistry*; D002073:Butanes / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry; D006031:Glycosylation; D006923:Hymecromone / Q000031:analogs & derivatives* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*
D000957:Antigens, Viral, Tumor; D002073:Butanes; D004187:Disaccharides; D012821:Silanes; C512229:di-tert-butylsilylene; D006923:Hymecromone