title: Application of the OMERACT filter to scoring methods for magnetic resonance imaging of the sacroiliac joints and the spine. Recommendations for a research agenda at OMERACT 7.
abstract: Magnetic resolution imaging (MRI) is a promising tool in the assessment of inflammation and structural damage in clinical trials in ankylosing spondylitis (AS). The ASAS/OMERACT MRI in AS working group, a collaborative initiative of rheumatologists and musculoskeletal radiologists with a special interest in this field, collected data on all available scoring methods for both sacroiliac (SI) joints and spine, and tested them with respect to the OMERACT filter. These data were presented together with the technical specifications of all methods at the OMERACT 7 conference. In addition, the results of 2 separate experiments on the inter-reader reliability of scoring methods to assess activity in SI joints, and on the comparison of STIR sequence versus T1 post-gadolinium (Gd) sequence for the spine, were presented. Thereafter, 8 groups discussed these data and proposed a research agenda, each on a different topic. This information was reported back to all participants and a prioritized research agenda was compiled by voting. Research on scoring methods for assessing disease activity, in both the spine and SI joints, was considered most important. Research on assessing structural damage was considered less important. The specific process and results of this initiative are discussed.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, University Maastricht, 6202 AZ Maastricht, The Netherlands. dhe@sint.azm.nl
authors.forename: Désirée M F M
authors.initials: DM
authors.lastname: van der Heijde
authors.forename: Robert B M
authors.initials: RB
authors.lastname: Landewé
authors.forename: Kay-Geert A
authors.initials: KG
authors.lastname: Hermann
authors.forename: Anne-Grethe
authors.initials: AG
authors.lastname: Jurik
authors.forename: Walter P
authors.initials: WP
authors.lastname: Maksymowych
authors.forename: Martin
authors.initials: M
authors.lastname: Rudwaleit
authors.forename: Philip J
authors.initials: PJ
authors.lastname: O'Connor
authors.forename: Jürgen
authors.initials: J
authors.lastname: Braun
mesh_terms: D035843:Biomedical Research; D002986:Clinical Trials as Topic / Q000379:methods / Q000592:standards; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D012219:Rheumatology / Q000379:methods* / Q000592:standards; D012446:Sacroiliac Joint / Q000473:pathology*; D012680:Sensitivity and Specificity; D013131:Spine / Q000473:pathology*; D013167:Spondylitis, Ankylosing / Q000175:diagnosis