Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion.
Short-term selective breeding created mouse lines divergent for ethanol drinking (high drinking short-term selected line [STDRHI], low drinking [STDRLO]) or ethanol-induced conditioned taste aversion (CTA; high [HTA], low [LTA]). Compared with STDRLO, STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned place preference (CPP), and showed reduced ethanol stimulation and sensitization under some conditions; a line difference in ethanol-induced CTA was not consistently found. Compared with LTA, HTA mice consumed less ethanol but were similar in saccharin consumption, sensitivity to ethanol-induced CPP, and ethanol-induced locomotor stimulation and sensitization. These data suggest that ethanol drinking is genetically associated with several reward-and aversion-related traits. The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2.
Phillips
Tamara J
TJ
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239, USA. phillipt@ohsu.edu
Broadbent
Julie
J
Burkhart-Kasch
Sue
S
Henderson
Carly
C
Wenger
Charlotte D
CD
McMullin
Carrie
C
McKinnon
Carrie S
CS
Cunningham
Christopher L
CL
D000428:Alcohol Drinking / Q000235:genetics*; D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001522:Behavior, Animal; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010641:Phenotype; D011803:Quinine / Q000008:administration & dosage; D012201:Reward; D012439:Saccharin / Q000008:administration & dosage; D012641:Selection, Genetic; D012737:Sex Factors; D013223:Statistics as Topic; D013549:Sweetening Agents / Q000008:administration & dosage; D013997:Time Factors
D002492:Central Nervous System Depressants; D013549:Sweetening Agents; D000431:Ethanol; D011803:Quinine; D012439:Saccharin