title: Adding some SPICE to DAS.
abstract: The distributed annotation system (DAS) defines a communication protocol used to exchange biological annotations. It is motivated by the idea that annotations should not be provided by single centralized databases but instead be spread over multiple sites. Data distribution, performed by DAS servers, is separated from visualization, which is carried out by DAS clients. The original DAS protocol was designed to serve annotation of genomic sequences. We have extended the protocol to be applicable to macromolecular structures. Here we present SPICE, a new DAS client that can be used to visualize protein sequence and structure annotations.
  
  
  BACKGROUND
  http://www.efamily.org.uk/software/dasclients/spice/
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, UK. ap3@sanger.ac.uk
authors.forename: Andreas
authors.initials: A
authors.lastname: Prlić
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Down
authors.forename: Tim J P
authors.initials: TJ
authors.lastname: Hubbard
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D003196:Computer Graphics; D003198:Computer Simulation; D003628:Database Management Systems; D030562:Databases, Protein; D016247:Information Storage and Retrieval / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D016415:Sequence Alignment / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D011506:Proteins