title: Mechanisms for incorporation of glycerol-derived precursors into polyketide metabolites.
abstract: Several polyketide secondary metabolites are shown by feeding experiments to incorporate glycerol-derived 3-carbon starter units, 2-carbon extender units, or 3-carbon branches into their hydrocarbon chains. In recent years, genetic studies have begun to elucidate the mechanisms by which this occurs. In this article we review the incorporation of glycerol-derived precursors into polyketides and propose new mechanisms for the incorporation processes.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Walton
authors.forename: Christophe
authors.initials: C
authors.lastname: Corre
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Challis
mesh_terms: D005990:Glycerol / Q000378:metabolism*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D048630:Polyketide Synthases; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism*
chemical_list: D018942:Macrolides; D048630:Polyketide Synthases; D005990:Glycerol