title: Organ-specific ligation-induced changes in harmonic components of the pulse spectrum and regional vasoconstrictor selectivity in Wistar rats.
abstract: It has been shown previously that the amplitudes of the harmonic components of the pulse spectrum vary in specific patterns when the arteries leading to different organs are ligated, with the variations in the harmonics being linearly additive. Since ligation can be regarded as a vast increase in organ resistance, the present study examined the potential of using these ligation-induced variations in the pulse spectrum as reference parameters for an increase in vascular resistance and for regional vasoconstrictor selectivity. A vasoconstrictor, either arginine vasopressin (AVP) or angiotensin II (Ang II), was infused into anaesthetized Wistar rats via the femoral vein for 1 h. The distinct harmonic-specific drug effects on the pulse spectrum were simulated by combining renal artery and superior mesenteric artery ligations in different ratios, the ratio with the lowest mean square difference determining the regional drug selectivity. The ratios indicated that the effect of AVP on the pulse spectrum was attributable to the combined effect of ligating the renal and superior mesenteric arteries, while the effect of Ang II was attributable to ligation of the renal artery. The results are comparable with those of investigations of regional vascular resistance performed using traditional methods. Our findings indicate that the ligation-induced variations in the pulse spectrum can be used to determine regional increases in vascular resistance. This implies that blood pressure can be used as the sole parameter to determine which arterial bed has been affected by the vasoconstrictor, and how seriously.
authors.affiliation: Biophysics Laboratory, Institute of Physics, Academia Sinica, Nankang, Taipei, Taiwan 11529, ROC.
authors.forename: Tse Lin
authors.initials: TL
authors.lastname: Hsu
authors.forename: Pin Tsun
authors.initials: PT
authors.lastname: Chao
authors.forename: Hsin
authors.initials: H
authors.lastname: Hsiu
authors.forename: Wei Kung
authors.initials: WK
authors.lastname: Wang
authors.forename: Sai Ping
authors.initials: SP
authors.lastname: Li
authors.forename: Yuh Ying Lin
authors.initials: YY
authors.lastname: Wang
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage*; D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D008026:Ligation; D008297:Male; D017538:Mesenteric Artery, Superior / Q000601:surgery; D023421:Models, Animal; D011674:Pulse; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012077:Renal Artery / Q000601:surgery; D012079:Renal Circulation / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D001127:Arginine Vasopressin