[Analysis on prognostic factors of liver failure in children].
OBJECTIVE
To analyze the prognostic factors of liver failure in children.


METHODS
The clinical data of 105 children with liver failure treated in the No. 302 Hospital in the past 17 years were retrospectively analyzed. The related factors were analysed by EXCELL 2000 and STATA 7.0, multivariate statistical analysis was performed by Logistic regression.


RESULTS
(1) A total of 72 children died and the mortality was 68.6%. (2) Univariate statistical analysis showed that the factors significantly correlated with death were age, clinical type and stage of liver failure, decrease in prothrombin activity (PTA) and albumin (AIB) level, increase in serum level of total bilirubin (TBIL), appearance of deviation of TBIL and ALT, complications and hepatic encephalopathy. There was no significant difference between boys and girls. (3) There was no significant difference among etiological diagnoses such as HBV infection, Wilson's disease, and unknown pathogeny. (4) Multivariate statistical analysis showed that PTA (P = 0.000) and TBIL (P = 0.029) were independent risk factors of mortality of the children.


CONCLUSIONS
The prognosis of liver failure in children is poor and mortality is high. PTA and TBIL might be useful for indicating prompt diagnosis and treatment to improve survival rate of the children with liver failure.
Zhu
Shi-shu
SS
Department of Pediatric Liver Diseases, The No 302 Hospital of The People's Liberation Army, Beijing, China.
Zhang
Hong-fei
HF
Chen
Ju-mei
JM
Yang
Xiao-jin
XJ
Dong
Yi
Y
Chen
Da-wei
DW
Xu
Zhi-qiang
ZQ
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D017093:Liver Failure / Q000175:diagnosis* / Q000401:mortality*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate