[The clinical significance of detection of urinary ceruloplasmin in type 2 diabetes].
OBJECTIVE
To evaluate the clinical significance of detection of urinary ceruloplasmin (Cp) in type 2 diabetes.


METHODS
To measure albumin/creatinine(Alb/Cr) and Cp/Cr in morning urinary specimens, from 134 normal controls and 3 960 diabetes, with RIA and ELISA separately.


RESULTS
(1) The range of urinary Cp/Cr for normal controls was 0.01 - 1.12 ng/mmol, median 0.36 ng/mmol. Cp/Cr > 0.924 ng/mmol was considered as abnormal, and there was no significant difference between males and females, as well as among subjects of different age. (2) The sensitivity and specificity of Cp/Cr were 90% and 66% respectively with Alb/Cr > 2.5 mg/mmol as a golden standard for diabetic nephropathy, and Kappa value 0.48. Urinary Cp/Cr correlated well with Alb/Cr. (3)After sub-maximal exercise, Cp/Cr elevated markedly with no significant change of Alb/Cr.


CONCLUSIONS
Urinary Cp/Cr could be considered as a marker of diabetic nephropathy and might be more sensitive than Alb/Cr.
Shi
H
H
Diabetes Research Department, Huashan Hospital, Fudan University, Shanghai 200040, China.
Fang
J
J
Yang
Y
Y
Jiang
W
W
Xie
J
J
Li
Y
Y
Zhu
X
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000652:urine; D002570:Ceruloplasmin / Q000652:urine*; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D003404:Creatinine; D002570:Ceruloplasmin