Elimination of CD4(+)CD25(+) T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB x NZW F mice.
The role of CD4(+)CD25+ T cell in glomerulonephritis (GN) development during the preactive phase was investigated in autoimmune-prone female NZB x NZW F1 (B/WF1) mice. The administration of anti-mouse CD25+ T-cell monoclonal antibody (PC61.5) 3 days after birth induced the development of GN with an increase in IgG2a antinuclear antibody, productions of IL-6 and IFN-gamma, whereas TGF-beta1 production decreased, compared to untreated control mice. The present study results suggest that CD4(+)CD25+ T cells may, at least in part, downregulate the development of GN during the preactive phase in B/WF1 mice.
Hayashi
Toshiharu
T
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yoshida, Yamaguchi, Japan. hayasi@yamaguchi-u.ac.jp
Hasegawa
Keiko
K
Adachi
Chie
C
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D015704:CD4 Antigens / Q000276:immunology*; D015926:Complement C3a / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis; D007150:Immunohistochemistry / Q000379:methods; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007668:Kidney / Q000276:immunology; D008180:Lupus Erythematosus, Systemic; D051379:Mice; D008814:Mice, Inbred NZB; D023421:Models, Animal; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000097:blood
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D015704:CD4 Antigens; D007070:Immunoglobulin A; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D016212:Transforming Growth Factor beta; D015847:Interleukin-4; D015926:Complement C3a; D007371:Interferon-gamma