Current issues in global tuberculosis control.
Despite attempts to standardize tuberculosis (TB) control strategies, there remains wide variation in the selection and implementation of control strategies within and among nations. Some of this variation is appropriate; based on wide variations in the available resources, the prevalence of TB infection, the incidence of TB disease, the relative contribution of reactivation versus recent transmission to incident cases, and the rate of HIV co-infection. This review will discuss three controversial questions relevant to global TB control: (1) What is the role of the treatment of latent TB infection in global TB control? (2) What are successful strategies to control immigrant TB in low incidence countries? (3) What are successful strategies to control TB in persons with HIV infection?
Frothingham
Richard
R
Department of Medicine, Duke University Medical Center, Durham, NC, USA. richard.frothingham@duke.edu
Stout
Jason E
JE
Hamilton
Carol Dukes
CD
D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000008:administration & dosage; D014943:Global Health; D015658:HIV Infections / Q000150:complications; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control*; D017735:Virus Latency
D000995:Antitubercular Agents; D001500:BCG Vaccine