Platelets and tissue factor.
Tissue factor (TF) is the most important initiator of intravascular coagulation. This article will review published evidence on the contribution of platelets to TF exposure to the circulating blood. The following mechanisms will be discussed: decryption of monocyte TF by platelets, contribution of platelets to TF expression in leukocytes, platelet-derived TF and its procoagulant activity, and activation of circulating TF by platelets.
Lösche
W
W
University Hospital Jena, Department of Anaesthesiology and Intensive Care Medicine, Research Centre Labeda, Jena, Germany. wolfgang.loesche@med.uni-jena.de
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008954:Models, Biological; D009000:Monocytes / Q000502:physiology; D013925:Thromboplastin / Q000096:biosynthesis / Q000502:physiology*
D013925:Thromboplastin