title: Cholangiocarcinoma presenting with severe gastroparesis and pseudoachalasia.
abstract: Tumor-associated gastroparesis, though reported in association with various malignancies, is rare in patients with cholangiocarcinoma. We report a 55-year-old woman who presented with dysphagia and recurrent vomiting. Esophagogastroduodenoscopy revealed dilated stomach and excess residue without organic obstruction. 99mTc sulfur colloid solid gastric emptying study, radio-opaque marker gut transit study, and esophageal manometry showed features suggestive of gastroparesis and achalasia cardia; electrogastrography revealed bradygastria. Cholangiocarcinoma was detected on CT scan performed after the patient developed jaundice two months later. The lesion was deemed surgically unresectable. She died four months later.
authors.affiliation: Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India. ghoshal@sgpgi.ac.in
authors.forename: Uday C
authors.initials: UC
authors.lastname: Ghoshal
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sachdeva
authors.forename: Abhinav
authors.initials: A
authors.lastname: Sharma
authors.forename: Dinesh
authors.initials: D
authors.lastname: Gupta
authors.forename: Asha
authors.initials: A
authors.lastname: Misra
mesh_terms: D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004931:Esophageal Achalasia / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D018589:Gastroparesis / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis; D014057:Tomography, X-Ray Computed