Titanium implant materials with improved biocompatibility through coating with phosphonate-anchored cyclic RGD peptides.
One key point for improving osseous integration of implants is to render them osteopromotive by specifically favoring the adhesion of osteoblasts. Mimicking the physiological adhesion process of osteoblasts to the extracellular matrix improves cell adhesion in vitro and results in improved and earlier osseous integration of implants in vivo. Our approach involves coating titanium implants with a tailor-made cyclic-RGD peptide, thus allowing them to bind to specific integrin receptors on the cell surface through multimeric phosphonates. The advantages of this very stable, new type of anchoring for practical application are presented.
Auernheimer
Jörg
J
Department Chemie, Lehrstuhl II für Organische Chemie, Technische Universität München, Garching, Germany.
Zukowski
Daniel
D
Dahmen
Claudia
C
Kantlehner
Martin
M
Enderle
Anja
A
Goodman
Simon L
SL
Kessler
Horst
H
D000818:Animals; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D016023:Integrins / Q000037:antagonists & inhibitors; D008422:Materials Testing; D051379:Mice; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D063065:Organophosphonates / Q000737:chemistry*; D010006:Osteoblasts / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D019736:Prostheses and Implants / Q000639:trends*; D014025:Titanium / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D016023:Integrins; D009842:Oligopeptides; D063065:Organophosphonates; D010456:Peptides, Cyclic; C047981:arginyl-glycyl-aspartic acid; D014025:Titanium