title: Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides.
abstract: [reaction: see text] A tandem dimerization-macrocyclization approach using 1,3-dipolar azide-alkyne cycloaddition reactions has been employed in the facile and convergent solution phase syntheses of C2 symmetric cyclic peptide scaffolds bearing triazole epsilon2-amino acids as dipeptide surrogates.
authors.affiliation: Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Jan H
authors.initials: JH
authors.lastname: van Maarseveen
authors.forename: W Seth
authors.initials: WS
authors.lastname: Horne
authors.forename: M Reza
authors.initials: MR
authors.lastname: Ghadiri
mesh_terms: D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D012254:Ribavirin / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D010456:Peptides, Cyclic; D012254:Ribavirin; C033706:tiazofurin