Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf. cristagalli.
The inhibition of superoxide production by human neutrophils has been used to screen New Zealand's unique biota for anti-inflammatory natural products. Bioactivity-directed isolation on an extract of the sponge Dysidea cf. cristagalli led to a new sesquiterpene-quinone (4) with anti-inflammatory activity, plus acetylated hydroquinone (3). These compounds inhibited superoxide production in vitro with IC50's of 3 microM (3) and 11 microM (4).
McNamara
Catherine E
CE
TerraMarine Pharmaceuticals, New Zealand Institute for Crop & Food Research Ltd, Chemistry Department, University of Otago, PO Box 56, Dunedin, New Zealand.
Larsen
Lesley
L
Perry
Nigel B
NB
Harper
Jacquie L
JL
Berridge
Michael V
MV
Chia
Elizabeth W
EW
Kelly
Michelle
M
Webb
Victoria L
VL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D009520:New Zealand; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
C505325:20-O-acetyl-21-hydroxy-ent-isozonarol; C505324:21-hydroxy-ent-isozonarone; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011809:Quinones; D012717:Sesquiterpenes; D013481:Superoxides