The genesis of RNA interference, its potential clinical applications, and implications in gynecologic cancer.
OBJECTIVE
This review will discuss the discovery and development of RNA interference (RNAi) technology, small interfering RNA (siRNA) design and delivery, and the implications of RNAi on gynecologic cancers.


METHODS
Systematic review of English language literature using searches for RNAi and gynecologic cancers in established databases, including Pubmed and Ovid, was employed.


RESULTS
The high degrees of efficiency and specificity are the main advantages of RNAi. Consequently, RNAi is used in functional genomics and developing therapies for the treatment of viral infection, dominant disorders, neurological disorders, and cancers, including gynecologic cancers.


CONCLUSIONS
RNAi represents an exciting technology for functional genomics by selective targeting of genes. While issues regarding delivery remain, the therapeutic advantages of siRNA in cancer treatment warrant further investigation.
Tebes
Stephen J
SJ
Department of Obstetrics and Gynecology, University of South Florida, Tampa, FL 33612, USA.
Kruk
Patricia A
PA
D000818:Animals; D005260:Female; D015316:Genetic Therapy / Q000379:methods; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000235:genetics
D034741:RNA, Small Interfering