title: [Effects of glutamine granules on immunofunction in trauma patients: a double-blind randomized controlled, multi-center clinical trail with 120 patients].
abstract: OBJECTIVE
  To evaluate the effect of glutamine granules on immunofunction in severe burns and trauma patients.
  
  
  METHODS
  One hundred and twenty patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients). There was isonitrogenous and isocaloric intake in both groups. GLN and P group patients had been given glutamine granules or placebo (glycine) at 0.5 g.kg(-1).d(-1) for 7 days, respectively. The level of plasma glutamine and some index of immunofunction were determined, and the complication and side effect were also observed.
  
  
  RESULTS
  After 7 days of taking glutamine granules orally, plasma GLN concentration was significantly higher than that in P group [(593 +/- 185) micromol/L vs (407 +/- 190) micromol/L)] (P < 0.01). IL-2 level, CD(4)/CD(8) ratio, PMN swallow ratio in GLN group were significantly higher than those in P group (P < 0.05-0.01), but the concentration of IgG, IgM, C(3)/C(4) were not significantly different when compared with P group (P > 0.05). In addition, the occurrence of side effect in both groups was seldom.
  
  
  CONCLUSIONS
  Taking glutamine granules could increase plasma GLN concentration, enhance body immunofunction, and using glutamine granules is safe.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Peng
authors.forename: Zhong-yi
authors.initials: ZY
authors.lastname: You
authors.forename: Xian-kai
authors.initials: XK
authors.lastname: Huang
authors.forename: Cai-quan
authors.initials: CQ
authors.lastname: Zhang
authors.forename: Guang-zhao
authors.initials: GZ
authors.lastname: He
authors.forename: Zhu-fu
authors.initials: ZF
authors.lastname: Quan
authors.forename: Wei-guang
authors.initials: WG
authors.lastname: Xie
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005973:Glutamine / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014947:Wounds and Injuries / Q000097:blood / Q000188:drug therapy* / Q000276:immunology
chemical_list: D005973:Glutamine