title: Diffusion-weighted MR study of femoral head avascular necrosis in severe acute respiratory syndrome patients.
abstract: OBJECTIVE
  To evaluate the apparent diffusion coefficient (ADC) of femoral head avascular necrosis (AVN) in severe acute respiratory syndrome (SARS).
  
  
  METHODS
  Seventy-nine SARS patients with hip pain underwent both conventional and diffusion-weighted MRI (b-value=0-1000 seconds/mm(2)). The abnormal regions on the diffusion-weighted images were outlined by using the conventional images as guides, and the ADCs were calculated. The ADC differences between normal and AVN femoral heads were compared.
  
  
  RESULTS
  Of the 158 hips examined, 28 had AVN (11 with bilateral hip AVN, three with right hip AVN, and three with left hip AVN). The mean ADC was markedly greater in the AVN femoral head (1.66 x 10(-3) mm(2)/second+/-0.20) than in the normal femoral head (0.47 x 10(-3) mm(2)/second+/-0.082; P<0.0001). There was no overlap between the normal and AVN femoral heads.
  
  
  CONCLUSIONS
  DWI can provide valuable information regarding the diffusion properties of femoral head AVN, and markedly increased diffusion was identified in AVN.
authors.affiliation: Department of Radiology, Peking University People's Hospital, Beijing, China. hongnan@bjmu.edu.cn
authors.forename: Nan
authors.initials: N
authors.lastname: Hong
authors.forename: Xiangke
authors.initials: X
authors.lastname: Du
authors.forename: Zhongshi
authors.initials: Z
authors.lastname: Nie
authors.forename: Sijun
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000465:Algorithms; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D045169:Severe Acute Respiratory Syndrome / Q000150:complications / Q000175:diagnosis*