title: Relationship between fetal weight, placental growth and litter size in mice from mid- to late-gestation.
abstract: In mammals, the placenta, which consists of maternal and fetal components, is important in fetal development because it supplies the fetus with the nourishment it needs. We investigated the effects of placental growth and litter size on mouse fetal weights from mid- to late-gestation. The mean weight of male fetuses at 13.5 days post coitum (dpc) was larger than that of females. Although there was a significant correlation between fetal and placental weights in both males and females during mid-gestation (P<0.05), there was no correlation during late-gestation. However, a significant correlation was observed between litter size and fetal weights in both males and females at 17.5 dpc (P<0.05). These findings suggest that fetal weight is regulated by placental growth during mid-gestation, while the effects of litter size are more prominent towards late-gestation.
authors.affiliation: Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan. h.iskw@med.id.yamagata-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Ryota
authors.initials: R
authors.lastname: Seki
authors.forename: Satoru
authors.initials: S
authors.lastname: Yokonishi
authors.forename: Toru
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D005260:Female; D020567:Fetal Weight; D005865:Gestational Age; D008098:Litter Size; D008297:Male; D051379:Mice; D009929:Organ Size; D010929:Placentation; D011247:Pregnancy; D012737:Sex Factors