title: Critical investigation of the CD14 promoter polymorphism: lack of a role for in vitro cytokine response and membrane CD14 expression.
abstract: Blood of volunteers, genotyped for the CD14 C(-159)-->T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.
authors.affiliation: Biochemical Pharmacology, University of Konstanz, P.O. Box M655, 78457 Konstanz, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: von Aulock
authors.forename: Jan
authors.initials: J
authors.lastname: Rupp
authors.forename: Katja
authors.initials: K
authors.lastname: Gueinzius
authors.forename: Matthias
authors.initials: M
authors.lastname: Maass
authors.forename: Corinna
authors.initials: C
authors.lastname: Hermann
mesh_terms: D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D005786:Gene Expression Regulation / Q000235:genetics; D005838:Genotype; D006801:Humans; D007109:Immunity; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008070:Lipopolysaccharides / Q000494:pharmacology; D009000:Monocytes / Q000276:immunology; D020641:Polymorphism, Single Nucleotide / Q000276:immunology*; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides