title: Nonreductive deiodination of ortho-iodo-hydroxylated arenes using tertiary amines.
abstract: A convenient and nonreductive deiodination is reported for the ortho-iodo-hydroxylated arenes including derivatives of quinolinol, phenol, and naphthol. Tertiary amines pyridine, triethylamine, and N-methylmorpholine in the presence of water initiated deiodination of ortho-iodo-hydroxylated arenes without affecting para-iodine and other reduction-susceptible groups. This reported method also works efficiently for polyiodinated systems. Simplicity, short reaction times, and absence of reducing catalyst are features of this method.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
authors.forename: Rahul Subhash
authors.initials: RS
authors.lastname: Talekar
authors.forename: Grace Shiahuy
authors.initials: GS
authors.lastname: Chen
authors.forename: Shin-Yu
authors.initials: SY
authors.lastname: Lai
authors.forename: Ji-Wang
authors.initials: JW
authors.lastname: Chern
mesh_terms: D000588:Amines / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D006900:Hydroxylation; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000588:Amines; D006841:Hydrocarbons, Aromatic; D007455:Iodine