title: Transfusion-free complex cardiac surgery with cardiopulmonary bypass in a 3.55-kg Jehovah's Witness neonate.
abstract: Complex cardiac surgery using cardiopulmonary bypass normally requires the transfusion of autologous blood components, particularly in neonates. This is predominately caused by the relatively high priming volume of the circuit with subsequent extreme hemodilution and the often extended and complex perfusions leading to progressive consumption of platelets and coagulation factors. We report on a strategy to minimize the cardiopulmonary bypass circuit and adjust the perfusion technique that resulted in transfusion-free correction of tetralogy of Fallot with an absent pulmonary valve and an aneurysm of the left pulmonary artery in a 3.55 kg Jehovah's Witness neonate boy.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany. koster@dhzb.de
authors.forename: Michael
authors.initials: M
authors.lastname: Huebler
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Boettcher
authors.forename: Andreas
authors.initials: A
authors.lastname: Koster
authors.forename: Michael
authors.initials: M
authors.lastname: Emeis
authors.forename: Peter
authors.initials: P
authors.lastname: Lange
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
mesh_terms: D000783:Aneurysm / Q000209:etiology; D001804:Blood Transfusion, Autologous; D002315:Cardiopulmonary Bypass / Q000379:methods*; D000075202:Contraindications; D006801:Humans; D007231:Infant, Newborn; D033221:Jehovah's Witnesses; D008297:Male; D011651:Pulmonary Artery; D011664:Pulmonary Valve / Q000002:abnormalities; D013771:Tetralogy of Fallot / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome; D016312:Treatment Refusal