Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.
Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
Lee
Seokjoon
S
Department of Basic Science, Yonsei University, Womju, Korea. sjlee@kd.ac.kr
Oh
Sangtae
S
Park
Gab-Man
GM
Kim
Tong-Soo
TS
Ryu
Jae-Sook
JS
Choi
Han-Kyu
HK
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D037621:Artemisinins; D002738:Chloroquine