[Study on the structure of periodic and chaotic patterns of AMP-DC-Cu-gel systems].
This is an in vitro model to mimic the conditions present during gallstone formation. Adenosine mono-phosphate (AMP), an important bio-molecule, was chosen. Its effect on the formation of periodic/chaotic patterns in the deoxycholate-CuCl2-gel and deoxycholate-CuCl2-glucose-gel systems were studied. FTIR spectroscopy was used to identify the structure of the precipitates. The results indicate that the patterns formed in the systems with AMP are different. And FTIR spectra show that AMP may also be involved in the coordination sphere of Cu2+ ion. The results are more complicated in the deoxycholate-CuCl2 system containing glucose, suggesting that the nonlinear scientific concept should be considered in understanding gallstone formation.
Yin
Wen-xuan
WX
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Liu
Yu-feng
YF
Zhao
Ying
Y
Gao
Qing-yu
QY
Wu
Jin-guang
JG
D000249:Adenosine Monophosphate / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003840:Deoxycholic Acid / Q000737:chemistry*; D042882:Gallstones / Q000737:chemistry / Q000473:pathology; D005782:Gels / Q000737:chemistry*; D006801:Humans; D008953:Models, Anatomic; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared
D005782:Gels; D003840:Deoxycholic Acid; D000249:Adenosine Monophosphate; D003300:Copper; C029892:cupric chloride