[The effect of one-time external low- and high-dose gamma-irradiation on rat thyroid structure at the acute and remote periods].
A study of the morphological structure of the thyroid was made at the acute (1, 3, 6 hours) and remote periods (1, 4, 24, 48 weeks) following the external gamma-irradiation at doses of 0.25-5.0 Gy using histologic and electron microscopic methods. At the acute period, morphological changes prevailed, which reflect the functional alterations (changes of the nucleic and of the follicular diameters and of the colloid density). Frequently they hare a non-synchronous character. At more remote periods, destructive (colloidorrhage, desquamation, hemorrhage) and reparative changes reveal in thyroid, which and by the development of the sclerotic processes and of the morphological signs of decreased functional activity of the gland (increased follicular size and colloidal density, flatness of follicular epithelium and pronounced decreasing of the thyrocytes ultra structure number). The presence of such morphological changes after high and low-dose irradiation (<1.0 Gy) shows high sensitivity of the thyroid to single external radiation.
Nadol'nik
L I
LI
Kardash
N A
NA
Martynchik
D I
DI
Kravchuk
R I
RI
Netsetskaia
Z V
ZV
Basinskiĭ
V A
VA
Vinogradov
V V
VV
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D008854:Microscopy, Electron; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000528:radiation effects* / Q000648:ultrastructure*; D013997:Time Factors