Compounds structurally related to tamoxifen as openers of large-conductance calcium-activated K+ channel.
We found that a variety of compounds containing partial structures of tamoxifen showed activity as chemical modulators of large-conductance calcium-activated K+ channels (BK channels).
Sha
Yu
Y
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
Tashima
Toshihiko
T
Mochizuki
Yumi
Y
Toriumi
Yoshimi
Y
Adachi-Akahane
Satomi
S
Nonomura
Taro
T
Cheng
Maosheng
M
Ohwada
Tomohiko
T
D004396:Coloring Agents / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D004396:Coloring Agents; D024681:Potassium Channels, Calcium-Activated; D013629:Tamoxifen