Catalytic decarboxylative sp-sp3 coupling.
A palladium-catalyzed 1,4-enyne synthesis was developed based the decarboxylative coupling of acetylides with allyl electrophiles. Stereochemical studies have implicated palladium-allyl-acetylides as intermediates. Thus, decarboxylative metalation was established as an environmentally benign alternative to transmetalation from alkynyl tin reagents.
Rayabarapu
Dinesh Kumar
DK
Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, USA.
Tunge
Jon A
JA