Prevention of onychomycosis reinfection for patients with complete cure of all 10 toenails: results of a double-blind, placebo-controlled, pilot study of prophylactic miconazole powder 2%.
The objective of this 2-year, double-blind, placebo-controlled, randomized trial involving 48 participants was to determine if biweekly miconazole powder prevents onychomycosis recurrence. Intent-to-treat analysis found no significant differences in mycologic, clinical, or complete onychomycosis reinfection rates or time to reinfection. Limitations include small sample size and dosing regimen.
Warshaw
Erin M
EM
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. erin.warshaw@med.va.gov
St Clair
Katherine R
KR
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy; D006801:Humans; D008297:Male; D008825:Miconazole / Q000627:therapeutic use*; D008875:Middle Aged; D014009:Onychomycosis / Q000517:prevention & control*; D010865:Pilot Projects; D012008:Recurrence
D000935:Antifungal Agents; D008825:Miconazole