Renal hypersensitivity vasculitis associated with dapsone.
We describe clinical and pathological features of kidney and skin involvement in a patient with hypersensitivity vasculitis associated with dapsone. Although visceral damage occurs rarely, similar skin and kidney histopathologic and immunohistochemical findings indicate that this organ is a target for type IV cell-mediated dapsone reaction. To our knowledge, this is the first reported case of renal hypersensitivity vasculitis associated with dapsone.
Alves-Rodrigues
Edson N
EN
Departamento de Clínica Médica, Hospital Universitário Júlio Müller, Universidade Federal de Mato Grosso, Cuiabá, Brazil.
Ribeiro
Luciano C
LC
Silva
Margareth D
MD
Takiuchi
Arley
A
Rabel-Filho
Osvaldo C
OC
Martini-Filho
Dino
D
Fontes
Cor J F
CJ
D000328:Adult; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002991:Clofazimine / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D003622:Dapsone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D007166:Immunosuppressive Agents; D007917:Leprostatic Agents; D003520:Cyclophosphamide; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin; D008775:Methylprednisolone