Risperidone half-life in a patient taking paroxetine -- a case report.
This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.
Barnhill
J
J
Susce
M T
MT
Diaz
F J
FJ
de Leon
J
J
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000097:blood* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D017374:Paroxetine / Q000097:blood* / Q000493:pharmacokinetics
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine