title: Nitric oxide in patients with chronic liver diseases.
abstract: OBJECTIVE
  Chronic liver disease (CLD) may be accompanied by portal hypertension (PHT). Nitric oxide (NO) system disturbances seem to play a key role in the pathogenesis of CLD and PHT. In this study we aim to assess if in chronic active hepatitis (CAH) and cirrhosis (CIR), CLD severity and etiology can be correlated with the serum level of NO metabolites.
  
  
  METHODS
  The study was performed on 92 patients divided according to the diagnosis and Child-Pugh class, and a control group of 10 healthy volunteers. Serum nitrite/nitrate and citrulline levels were measured in order to evaluate NO synthesis.
  
  
  CONCLUSIONS
  In CLD patients there was an increased NO production. In CIR NO synthesis increased more than in CAH. In CIR patients only nitrite/nitrate concentrations were correlated with citrulline levels. NO metabolites from CAH and CIR patients varied according to disease etiology, namely NO synthesis was more important in HCV-CLD than in alcoholic-CLD and HBV-CLD. In CIR patients, NO metabolites level increased with disease severity.
authors.affiliation: Department of Pathophysiology, University of Medicine and Pharmacy, 400020 Cluj-Napoca, Romania. alina.parvu@personal.ro
authors.forename: Alina Elena
authors.initials: AE
authors.lastname: Pârvu
authors.forename: Vasile
authors.initials: V
authors.lastname: Negrean
authors.forename: Luminiţa
authors.initials: L
authors.lastname: Pleşca-Manea
authors.forename: Angela
authors.initials: A
authors.lastname: Cosma
authors.forename: Anton
authors.initials: A
authors.lastname: Drăghici
authors.forename: Ana
authors.initials: A
authors.lastname: Uifălean
authors.forename: Remus
authors.initials: R
authors.lastname: Moldovan
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006521:Hepatitis, Chronic / Q000503:physiopathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology*; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide