title: Loss of apoptosis-inducing factor leads to an increase in reactive oxygen species, and an impairment of respiration that can be reversed by antioxidants.
authors.forename: N
authors.initials: N
authors.lastname: Apostolova
authors.forename: A M
authors.initials: AM
authors.lastname: Cervera
authors.forename: V M
authors.initials: VM
authors.lastname: Victor
authors.forename: S
authors.initials: S
authors.lastname: Cadenas
authors.forename: A
authors.initials: A
authors.lastname: Sanjuan-Pla
authors.forename: A
authors.initials: A
authors.lastname: Alvarez-Barrientos
authors.forename: J V
authors.initials: JV
authors.lastname: Esplugues
authors.forename: K J
authors.initials: KJ
authors.lastname: McCreath
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D051033:Apoptosis Inducing Factor / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D045744:Cell Line, Tumor; D019069:Cell Respiration / Q000187:drug effects / Q000502:physiology*; D005786:Gene Expression Regulation / Q000187:drug effects; D020868:Gene Silencing; D005822:Genetic Vectors; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D034741:RNA, Small Interfering / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D051033:Apoptosis Inducing Factor; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D034741:RNA, Small Interfering; D017382:Reactive Oxygen Species; D013481:Superoxides