title: Two new triterpenoid glycosides isolated from Aesculus assamica GRIFF.
abstract: Phytochemical study of the ethanol extract of the seeds of Aesculus assamica led to the isolation of two new triterpenoid saponins. The structure of the new compounds were elucidated on the basis of spectral data to be 28-O-acetyl-21-O-(4-O-angeloyl)-6-deoxy-beta-glucopyranosyl-3-O-[beta-glucopyranosyl(1-2)-O-[beta-glucopyranosyl(1-4)]-beta-glucuronopyranosyl]protoaescigenin (1), and 21-O-(4-O-angeloyl)-6-deoxy-beta-glucopyranosyl-3-O-[beta-glucopyranosyl(1-2)-O-[beta-glucopyranosyl(1-4)]-beta-glucuronopyranosyl]protoaescigenin (2). Their in vitro bioactivity against plant pathogenic fungus Pyricularia oryzae and cytotoxicity against K562 and HCT-15 cell lines were evaluated.
authors.affiliation: Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, People's Republic of China. liuhongwei60@hotmail.com
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Nali
authors.initials: N
authors.lastname: Wang
authors.forename: Sanlin
authors.initials: S
authors.lastname: Jin
authors.forename: Bin
authors.initials: B
authors.lastname: Cai
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Guoping
authors.initials: G
authors.lastname: Cai
mesh_terms: D031319:Aesculus / Q000737:chemistry*; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes