Pepducins: an effective means to inhibit GPCR signaling by neutrophils.
G-protein-coupled receptors (GPCRs) have a central role not only in the competent development of an innate myeloid response to foreign pathogens but, if dysregulated, might contribute to phagocyte-mediated organ injury. Here, recent findings from a study in which neutrophil trafficking is inhibited by using a novel family of GPCR signaling inhibitors, known as pepducins, are discussed.
Lomas-Neira
Joanne
J
Shock-Trauma Research Laboratories, Division of Surgical Research, Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, Aldrich 227, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA.
Ayala
Alfred
A
D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
D016207:Cytokines; D043562:Receptors, G-Protein-Coupled