Pd-catalyzed asymmetric allylic amination using aspartic acid derived P-chirogenic diaminophosphine oxides: DIAPHOXs.
[reaction: see text] A Pd-catalyzed asymmetric allylic amination using aspartic acid derived P-chirogenic diaminophosphine oxides (DIAPHOXs) is described. Asymmetric allylic amination of both linear and cyclic substrates proceeded at room temperature to give the chiral allylic amines in 72-99% ee.
Nemoto
Tetsuhiro
T
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.
Masuda
Takamasa
T
Akimoto
Yuichi
Y
Fukuyama
Takashi
T
Hamada
Yasumasa
Y
D000586:Amination; D001224:Aspartic Acid / Q000737:chemistry*; D001596:Benzylamines / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D010105:Oxygenases / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism
D001596:Benzylamines; D002254:Carbonates; D010087:Oxides; D010720:Phosphines; D012997:Solvents; D001224:Aspartic Acid; D010165:Palladium; C030796:benzylamine; D010105:Oxygenases; C072883:alkene monooxygenase