title: Lack of association of CCR gene polymorphisms and left ventricular hypertrophy in essential hypertension.
abstract: Left ventricular hypertrophy (LVH) is a major determinant of heart damage. Scientific evidence suggests the influence of genetic factors, but these have yet to be completely clarified. This study investigates a possible relationship between LVH and two chemokine receptor (CCR) gene polymorphisms: CCR5delta32 and CCR264I. Essential hypertensive out-patients (n=118, grade I-II, age 27-54) were recruited from the Catholic University Hypertension Centre. For each subject, clinical data on office blood pressure and M-mode/2D echocardiography were collected. Statistical analysis did not show a significant association between the CCR polymorphisms and LVH in the study population.
authors.affiliation: Hypertension Center of the Catholic University Medical School, Rome, Italy. mamettim@tin.it
authors.forename: M
authors.initials: M
authors.lastname: Mettimano
authors.forename: M L
authors.initials: ML
authors.lastname: Specchia
authors.forename: G
authors.initials: G
authors.lastname: La Torre
authors.forename: A
authors.initials: A
authors.lastname: Bruno
authors.forename: G
authors.initials: G
authors.lastname: Ricciardi
authors.forename: V
authors.initials: V
authors.lastname: Romano-Spica
authors.forename: L
authors.initials: L
authors.lastname: Savi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019707:Receptors, Chemokine / Q000235:genetics*; D012044:Regression Analysis
chemical_list: D019707:Receptors, Chemokine