title: Poor results after augmenting autograft with xenograft (Surgibone) in hip revision surgery: a report of 27 cases.
abstract: BACKGROUND
  Surgibone Unilab is prepared from bovine bone and contains hydroxyapatite and protein. It is supposed to be immunogenically inert but the protein could be antigenic in man.
  
  
  METHODS
  We followed 27 patients for an average of 2.5 (1-5) years, all of whom had received Surgibone mixed with autograft to fill in defects in the acetabulum and the proximal femur in revision hip surgery.
  
  
  RESULTS
  In 17 patients, there was apparently complete incorporation of the bone graft within 6 months. In 3 of these patients, the graft was incorporated after 3 months. In 3 patients, however, there was no incorporation of the graft as late as 3 years after the operation. 3 other patients appeared to have a type of graft rejection (pseudoinfection). 1 other patient suffered MRSA deep infection of the prosthesis which resulted in removal of the implants 1 month postoperatively.
  
  
  CONCLUSIONS
  Use of Surgibone xenograft in revision hip surgery, even in combination with autograft, resulted in failure and the need for rerevision in at least one quarter of the cases studied.
authors.affiliation: Orthopaedic Department, Epsom General Hospital, Surrey, UK.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Charalambides
authors.forename: Marilyn
authors.initials: M
authors.lastname: Beer
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Cobb
mesh_terms: D000077:Acetabulum / Q000473:pathology / Q000601:surgery; D000368:Aged; D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D018786:Bone Substitutes / Q000009:adverse effects; D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods; D002417:Cattle; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006084:Graft Rejection; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000473:pathology; D012086:Reoperation; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes