[Ovarian androgenesis in women after menopause].
Menopause state doesn't mean total ovarian failure. Function of stromal cells is maintained and steroids, especially androgens, are produced. The role of androgenesis after menopause is important because of general androgens activity and their influence on some symptoms characteristic for perimenopausal period. From the other side, these hormones are necessary for the proper quality of life connected with bone mass density, libido, mood and physical activity. Knowledge of postmenopausal ovarian androgenesis and its influence on total androgens level is still not completed. On the basis of result of immunohistochemical assays it was found, that T and A postmenopausal production is depended on: hyperplasia of stromal tissue, receptors of Gn-FSH and Gn-LH, steroids receptors: ER, PR and AR, enzymes: P-140 aromatase, 3-beta HSD, 17-beta HSD activity. But influence the estrogen replacement therapy on these factors is still unknown.
Brodowska
Agnieszka
A
Pomorska Akademia Medyczna w Szczecinie, Klinika Rozrodczości i Ginekologii.
Starczewski
Andrzej
A
Laszczyńska
Maria
M
Szydłowska
Iwona
I
D000728:Androgens / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D010053:Ovary / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism*
D000728:Androgens