Cytotoxic limonoids from Brazilian Melia azedarach.
Three new C-seco limonoids (1-3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.
Zhou
Honglei
H
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Hamazaki
Atsuko
A
Fontana
Jose Domingos
JD
Takahashi
Hironobu
H
Wandscheer
Carolina Bueno
CB
Fukuyama
Yoshiyasu
Y
D001938:Brazil; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D031586:Melia azedarach / Q000737:chemistry*; D008968:Molecular Conformation; D012015:Reference Standards
D036701:Limonins