HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women.
A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neoplasia. HLA-B15 was found to be protective for CIN III/ICC overall (p(corrected) = 0.003), and for HPV52-positive CIN III/ICC (p(corrected) = 0.003). A marginal protective effect of B15 was observed for HPV16-positive CIN III/ICC, but no significant associations were revealed for HPV18- or HPV58-positive cases. None of the HLA-B alleles were found to confer an increased risk for cervical neoplasia. HLA-B15 is common among Asian for whom HPV52, a worldwide uncommon HPV type, also exists in a relatively high prevalence. It would also be worthwhile to assess the association between HLA-B15, HPV52 and cervical cancer in other Asian populations.
Chan
Paul K S
PK
Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
Cheung
Jo L K
JL
Cheung
Tak-Hong
TH
Lin
Che-kit
CK
Tam
Ann O Y
AO
Chan
Denise P C
DP
Zhou
Daniel X
DX
Lo
Keith W K
KW
Yim
So-Fan
SF
Siu
Shing-Shun N
SS
D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D052685:Alphapapillomavirus / Q000145:classification / Q000235:genetics; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000208:ethnology* / Q000235:genetics / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000208:ethnology* / Q000235:genetics / Q000821:virology
D004279:DNA, Viral; D015235:HLA-B Antigens