title: Biochemical and histological studies on H2-receptor antagonist ranitidine-induced hepatotoxicity in rats.
abstract: This study was designed to investigate the hepatotoxicity of ranitidine treatment in dose levels of 10, 30, and 50 mg/kg b.wt. for 3 weeks period in male rats. The results showed some adverse changes in rats treated with either 10 or 30 mg/kg. Treatment with dose of 50 mg/kg produced marked increase in the activity of both acid phosphatase in liver and aspartate aminotransferase in serum and liver, with a tendency for increase in serum alanine aminotransferase activity. Also, a significant decrease in the serum activity of both amylase and alkaline phosphatase was noted. Microscopic examination of livers of the same animals revealed absence of some hepatic cells, pyknotic nuclei, dilatation of blood sinusoids, binucleated cells, and infiltration of lymphocytes. These biochemical and histological changes indicate that ranitidine when given chronically in high dose could produce hepatotoxicity in rats.
authors.affiliation: Zoology Department, Faculty of Science, Mansoura University, Egypt. faried@mans.edu.eg
authors.forename: Faried A E
authors.initials: FA
authors.lastname: Hemieda
authors.forename: El-Sayed K
authors.initials: el-SK
authors.lastname: Abdel-Hady
authors.forename: Mostafa A Abou
authors.initials: MA
authors.lastname: Elnga
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011899:Ranitidine / Q000633:toxicity*; D051381:Rats
chemical_list: D006635:Histamine H2 Antagonists; D011899:Ranitidine; D001219:Aspartate Aminotransferases; D000135:Acid Phosphatase