Interaction of smoking and radon in rats: a biologically based mechanistic model.
Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acting on transformation and inducing a reduction of the radon dose to the target cells after a smoking period gives an acceptable description of the data.
Heidenreich
W F
WF
GSF-Institute for Radiation Protection, 85764 Neuherberg, Germany. heidenreich@gsf.de
Morlier
J P
JP
Monchaux
G
G
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D003043:Cocarcinogenesis; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011886:Radon / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors
D011886:Radon