title: Normalization of cancer antigen 125 after mitral valve replacement in a patient with congestive heart failure due to mitral valve endocarditis.
abstract: A 63-year-old woman with a history of uterine cancer was admitted to our hospital with dyspnea and stroke. Echocardiography showed a huge vegetation attached to the posterior mitral leaflet with severe mitral regurgitation. Blood culture identified Streptococcus galactiae. The serum level of cancer antigen 125 (CA125) was elevated at 199.4 U/ml. Resection of infected tissue including mobile vegetation and replacement of mitral valve were performed. The postoperative course was uneventful and the patient was discharged after 4 weeks of antibiotic therapy. The values of CA125 returned to normal (less than 15 U/ml) on the 90th postoperative day. These findings have suggested that a high serum value of CA125 is a possible indicator of infection-related congestive heart failure.
authors.affiliation: Department of Surgery II, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugishita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imagawa
authors.forename: Kanji
authors.initials: K
authors.lastname: Kawachi
authors.forename: Shinnji
authors.initials: S
authors.lastname: Takano
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsunooka
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Shikata
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000382:microbiology / Q000601:surgery*; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000209:etiology*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000601:surgery*; D013290:Streptococcal Infections
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen