The transformation of pediatric gliomatosis cerebri to cerebellar glioblastoma multiforme presenting as supra- and infratentorial acute disseminated encephalomyelitis. Case report.
Cerebellar glioblastoma multiforme (GBM) is a rare entity in adults and an extremely rare entity in children. Approximately 30 cases have been reported in the literature. The authors report the case of a histologically confirmed cerebellar GBM presenting initially as supra- and infratentorial gliomatosis cerebri. Acute disseminated encephalomyelitis had been diagnosed in the patient and that diagnosis remained until near the end of his treatment. This case underscores the need for recognizing the clinical presentation of gliomatosis cerebri and multifocal GBM in the pediatric subpopulation thought to harbor demyelinating disease.
Senatus
Patrick B
PB
Department of Neurological Surgery, Columbia College of Physicians and Surgeons, Neurological Institute of New York, New York 10032, USA. pps19@columbia.edu
McClelland
Shearwood
S
Tanji
Kurenai
K
Khandji
Alexander
A
Huang
Judy
J
Feldstein
Neil
N
D002528:Cerebellar Neoplasms / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis*; D005909:Glioblastoma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000175:diagnosis* / Q000473:pathology