BK virus regulatory region sequence deletions in a case of human polyomavirus associated nephropathy (PVAN) after kidney transplantation.
The pathogenesis of polyomavirus-associated interstitial nephropathy (PVAN) in kidney transplant recipients is likely to depend upon multiple risk factors, which may include viral characteristics. We report a case of interstitial nephropathy in a young kidney allograft recipient, associated with a BK virus (BKV) strain with a rearranged transcription control region (TCR). BKV strains with deletions and nucleotide substitutions in the TCR were present in a kidney biopsy and urine samples. After retransplantation, following loss of renal function, a BKV strain with an archetypal TCR was detected in association with asymptomatic reactivation.
Azzi
Alberta
A
Department of Public Health, University of Firenze, Microbiology Unit, Viale Morgagni 48, 50134 Firenze, Italy. alberta.azzi@unifi.it
De Santis
Riccardo
R
Salotti
Vittorio
V
Di Pietro
Niccolò
N
Ginevri
Fabrizio
F
Comoli
Patrizia
P
D000293:Adolescent; D001739:BK Virus / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009395:Nephritis, Interstitial / Q000821:virology*; D027601:Polyomavirus Infections / Q000821:virology*; D012045:Regulatory Sequences, Nucleic Acid; D017384:Sequence Deletion; D014412:Tumor Virus Infections / Q000821:virology*