Use of stored serum from Uganda for development and evaluation of a human immunodeficiency virus type 1 testing algorithm involving multiple rapid immunoassays.
We report the development and evaluation of a human immunodeficiency virus type 1 testing algorithm consisting of three rapid antibody detection tests. Stored serum samples from Uganda were utilized with a final algorithm sensitivity of 100% and a specificity of 98.9% (95% confidence interval, 98.6% to 99.3%).
Singer
Darrell E
DE
Division of Retrovirology, WalterReed Army Institute of Research, Rockville, MD 20850, USA.
Kiwanuka
Noah
N
Serwadda
David
D
Nalugoda
Fred
F
Hird
Linda
L
Bulken-Hoover
Jamie
J
Kigozi
Godfrey
G
Malia
Jennifer A
JA
Calero
Eva K
EK
Sateren
Warren
W
Robb
Merlin L
ML
Wabwire-Mangen
Fred
F
Wawer
Maria
M
Gray
Ronald H
RH
Sewankambo
Nelson
N
Birx
Deborah L
DL
Michael
Nelson L
NL
D015492:AIDS Serodiagnosis; D000465:Algorithms; D016001:Confidence Intervals; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D012680:Sensitivity and Specificity; D044967:Serum; D013048:Specimen Handling / Q000379:methods*; D013997:Time Factors; D014454:Uganda
D015483:HIV Antibodies