title: Distinct influences of neonatal epidermal growth factor challenge on adult neurobehavioral traits in four mouse strains.
abstract: Epidermal growth factor (EGF) receptor (ErbB1) signals regulate dopaminergic development and function and are implicated in schizophrenia. We evaluated genetic effects on neurobehavioral changes induced by neonatal EGF administration, using four mouse strains. Subcutaneous EGF administration increased phosphorylation of brain ErbB1 in all strains, although DBA/2 and C57BL/6 mice had lower basal phosphorylation. Neonatal EGF treatment differentially influenced physical and behavioral/cognitive development, depending on mouse strain. Prepulse inhibition was decreased in DBA/2 and C57BL/6 mice but not C3H/He and ddY mice. Locomotor activity was accelerated in DBA/2 mice, but reduced in ddY mice. EGF treatment enhanced fear-learning performance with a tone cue in DBA/2 mice, but decreased performance with tone and context cues in C3H/He and ddY mice, respectively. The strain-dependent behavioral sensitivity was correlated with basal ErbB1 phosphorylation. Genetic components regulating brain ErbB1 signaling strongly influence the direction and strength of behavioral responses stemming from the neonatal neurotrophic perturbation.
authors.affiliation: Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi-dori 1-757, Niigata, 951-8585, Japan.
authors.forename: Manavu
authors.initials: M
authors.lastname: Tohmi
authors.forename: Noriko
authors.initials: N
authors.lastname: Tsuda
authors.forename: Makoto
authors.initials: M
authors.lastname: Mizuno
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takei
authors.forename: Paul W
authors.initials: PW
authors.lastname: Frankland
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nawa
mesh_terms: D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001245:Association Learning / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology*; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000502:physiology*; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D005824:Genetics, Behavioral; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D013216:Reflex, Startle / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity
chemical_list: D004815:Epidermal Growth Factor; D066246:ErbB Receptors