The BCR signalosome: where cell fate is decided.
B cell antigen receptor (BCR) engagement results in the assembly of a multimolecular complex at the cytosolic side of the plasma membrane, known as signalosome. Here we briefly review the current knowledge on the molecules which participate in the BCR signalosome and on the response modulators which control the final signal output by enhancing or dampening BCR signaling.
Ulivieri
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Department of Evolutionary Biology, University of Siena, Siena, Italy.
Baldari
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D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D018941:Antigens, CD19 / Q000378:metabolism; D018956:CD5 Antigens / Q000096:biosynthesis; D002352:Carrier Proteins / Q000737:chemistry; D019070:Cell Lineage; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000378:metabolism*; D017464:Receptors, Complement 3d / Q000378:metabolism; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D018941:Antigens, CD19; C113939:B cell linker protein; D018956:CD5 Antigens; D002352:Carrier Proteins; C098587:GAB1 protein, human; C490895:GAB2 protein, human; D010750:Phosphoproteins; D011947:Receptors, Antigen, B-Cell; D017464:Receptors, Complement 3d