Facile synthesis of the indeno-tetrahydropyridine core of haouamine A.
[reaction: see text] The tricyclic indeno-tetrahydropyridine core of haouamine A, containing five of the seven rings of the natural product, was constructed by a simple, concise route that features an acid-catalyzed Friedel-Crafts ring closure.
Smith
Nicole D
ND
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Hayashida
Joji
J
Rawal
Viresh H
VH
D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007192:Indenes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D000097566:Cyclophanes
D006576:Heterocyclic Compounds, 4 or More Rings; D007192:Indenes; D011725:Pyridines; C474767:haouamine A; D000097566:Cyclophanes; C474768:haouamine B; C512228:indeno-tetrahydropyridine; C023666:pyridine