Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH.
OBJECTIVE
Endothelin-1 (ET-1) is postulated to play an important role in the development of cerebral vasospasm (CVS) following SAH. This study was conducted to investigate the time course of ET-release in three different sources: CSF, plasma and microdialysate.


METHODS
In a prospective study ET-1-concentrations were measured in plasma, cisternal CSF and microdialysate in 20 patients with aneurysmal SAH for at least 8 days after hemorrhage.


RESULTS
ET-1 concentration in microdialysate was almost four times higher compared to CSF and plasma. (p<0.001) Only in CSF ET-1-release showed a significant increase over time with highest values on day 5 post ictus (p = 0.03). This was parallel to the increase of transcranial Doppler velocities. ET-1 in plasma and microdialysate did not change over time.


CONCLUSIONS
ET-1 may have a different biological function in different biological tissues. Only ET-1 in CSF seemed to be associated with CVS.
Kästner
S
S
Department of Neurosurgery, University Hospital Giessen, Giessen, Germany.
Oertel
M F
MF
Scharbrodt
W
W
Krause
M
M
Böker
D-K
DK
Deinsberger
W
W
D000368:Aged; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D020520:Brain Infarction / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D019332:Endothelin-1 / Q000097:blood / Q000134:cerebrospinal fluid*; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013346:Subarachnoid Space / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017585:Ultrasonography, Doppler, Transcranial; D020301:Vasospasm, Intracranial / Q000097:blood / Q000134:cerebrospinal fluid* / Q000209:etiology
D019332:Endothelin-1