title: [Comparative study of the biocompatibility of the porcine intestinal submucosa and bovine pericardium used as grafts in the inferior cava vein of dogs].
abstract: OBJECTIVE
  To compare the biocompatibility of the bovine pericardium and the small intestine submucosa (SIS) when used to repair a created defect in the inferior vena cava of dogs.
  
  
  METHODS
  Sixteen male mongrel dogs were submitted to a midline laparotomy incision. An elliptical segment (1.5 x 3.0 cm) of the inferior vena cava, below the renal veins, was excised. In 8 dogs, the A group, a patch of porcine small bowel submucosa was used to repair the defect. In the 8 remaining dogs, the B group, a bovine pericardium was implanted in the vena cava. On the 30th post-operative day an ultrasound was performed in order to identify stenosis. The euthanasia was accomplished in the 40th post-operative day. Stenosis of the vein was observed in 1 dog of A group and in 2 of the B group.
  
  
  RESULTS
  Partial thrombosis with collateral circulation was evidenced in 1 dog of the bovine pericardium group. A moderated chronic inflammatory process was evidenced in both groups. Microscopic evaluation, regarding endothelization of the implant, collagen deposition, smooth muscle growth, was similar in both groups.
  
  
  CONCLUSIONS
  SIS proved to be a functional graft patch for possessing local vena cava remodeling and its biocompatibility was similar to bovine pericardium.
authors.affiliation: Faculdade de Medicina, Pontifícia Universidade do Paraná. fernando.greca@bbs2.sul.com.br
authors.forename: Fernando Hintz
authors.initials: FH
authors.lastname: Greca
authors.forename: Lucia de
authors.initials: Ld
authors.lastname: Noronha
authors.forename: Francisco Diniz Afonso da
authors.initials: FD
authors.lastname: Costa
authors.forename: Zacarias Alves de
authors.initials: ZA
authors.lastname: Souza Filho
authors.forename: Andréa Thomaz
authors.initials: AT
authors.lastname: Soccol
authors.forename: André Néry
authors.initials: AN
authors.lastname: Feres
authors.forename: Jõao Ricardo
authors.initials: JR
authors.lastname: Duda
authors.forename: Eduardo
authors.initials: E
authors.lastname: Adams
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002417:Cattle; D004285:Dogs; D006648:Histocompatibility; D007413:Intestinal Mucosa / Q000637:transplantation*; D007421:Intestine, Small; D008297:Male; D010496:Pericardium / Q000637:transplantation*; D013552:Swine; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology / Q000601:surgery*