title: Short-term thyroxine administration leads to lipid peroxidation in renal and testicular tissues of rats with hypothyroidism.
abstract: Thyroid dysfunction brings about pathological changes in different organs of the body. The aim of the present study was to examine how experimental hypothyroidism and additional short-term high-dose thyroxine administration (one-week) affected lipid peroxidation in renal and testicular tissues of rats. The study was carried out on 30 male Spraque-Dawley rats. The experimental animals were divided into 3 groups as control, hypothyroidism and hypothyroidism + thyroxine administration. Both malondialdehyde (MDA) and glutathione (GSH) levels were lower in renal and testicular tissues of the hypothyroidism group than the control and hypothyroidism + thyroxine administration groups and the levels in hypothyroidism + thyroxine administration group were higher than those in the control and hypothyroidism groups (p < 0.001). Results of the study demonstrate that hypothyroidism reduced oxidant stress in kidney and testis tissues, but short-term, high-dose thyroxine administration in addition to hypothyroidism increased oxidant stress in the same tissues of rats.
authors.affiliation: Department of Physiology, Meram Medical School, Selcuk University, 42080 Konya, Turkey. rasimmogulkoc@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Mogulkoc
authors.forename: A K
authors.initials: AK
authors.lastname: Baltaci
authors.forename: E
authors.initials: E
authors.lastname: Oztekin
authors.forename: A
authors.initials: A
authors.lastname: Ozturk
authors.forename: A
authors.initials: A
authors.lastname: Sivrikaya
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D011441:Propylthiouracil / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism*; D013974:Thyroxine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D008315:Malondialdehyde; D011441:Propylthiouracil; D005978:Glutathione; D013974:Thyroxine