title: Bone marrow cryptococcosis: a case report.
abstract: A 35-year-old male presented with fever and bilateral cervical and axillary lymphadenopathy. Peripheral blood film examination revealed thrombocytopaenia. Bone marrow aspiration and trephine biopsy, done for evaluation of thrombocytopaenia and pyrexia showed presence of ill-defined granulomas along with cryptococcal yeast forms. Fine needle aspiration of lymph nodes, cerebrospinal fluid and sputum analyses also showed cryptococci. ELISA for Human Immunodeficiency Virus (HIV) antigen was positive. Granulomas, when found in bone marrow aspiration smears and trephine biopsy, are a valuable histological clue to an opportunistic infection. Disseminated fungal infection such as cryptococcosis should raise the possibility of immunosuppression, especially Acquired Immunodeficiency Syndrome. Bone marrow examination is a useful method of diagnosing opportunistic fungal and mycobacterial infections in patients with fever, anaemia or thrombocytopaenia and underlying HIV infection.
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Saravana
authors.forename: Debdatta
authors.initials: D
authors.lastname: Basu
authors.forename: S
authors.initials: S
authors.lastname: Chandrakumar
authors.forename: Bendangtoshi S
authors.initials: BS
authors.lastname: Longkumer
authors.forename: R P
authors.initials: RP
authors.lastname: Swaminathan
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000382:microbiology; D000328:Adult; D000818:Animals; D001855:Bone Marrow Diseases / Q000382:microbiology* / Q000473:pathology; D001856:Bone Marrow Examination; D003453:Cryptococcosis / Q000382:microbiology / Q000473:pathology*; D006099:Granuloma / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008297:Male