title: Antagonistic effects of methanolic extract of Polygala telephioides on morphine responses in mice.
abstract: The present study was undertaken to investigate the antagonistic effects of the methanolic extract of Polygala telephioides (PT) on morphine responses in mice. Single administration of PT tended to antagonize the morphine-induced analgesia in a hot-plate test. Moreover, PT (300 mg/kg, p.o.) improved the morphine-induced memory impairment in an elevated plus maze test. However, PT alone had no effect on behaviors in the open-field, hot-plate and elevated plus maze tests. We investigated the effects of PT on naloxone-induced jumping (as withdrawal sign) in morphine-dependent mice. To induce dependence, mice were twice daily treated with morphine (10-45 mg/kg, s.c.) for 5 days. Co-administrations of PT (10, 100 and 300 mg/kg, p.o.) during repeated morphine treatments significantly suppressed the naloxone (10 mg/kg, i.p.)-induced jumping. However, the naloxone-induced jumping was not affected by a single large administration of PT on the 5th day. The inhibitory effect of PT on the naloxone-induced jumping was due to the development of dependence rather than expression of withdrawal sign. Moreover, single administration of PT (30 mg/kg, p.o.) decreased the morphine levels in plasma. These results indicate that PT may be useful in facilitating narcotic detoxification.
authors.affiliation: Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Fukuoka city, Fukuoka, 814-0180 Fukuoka, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Egashira
authors.forename: Jian-Chen
authors.initials: JC
authors.lastname: Li
authors.forename: Ai
authors.initials: A
authors.lastname: Mizuki
authors.forename: Keita
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsuda
authors.forename: Megumi
authors.initials: M
authors.lastname: Osajima
authors.forename: Michihiko
authors.initials: M
authors.lastname: Matsushita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mishima
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Shuji
authors.initials: S
authors.lastname: Hara
authors.forename: Nobufumi
authors.initials: N
authors.lastname: Ono
authors.forename: Ryoji
authors.initials: R
authors.lastname: Nishimura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
authors.forename: Michihiro
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D000432:Methanol / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D031801:Polygala; D011930:Reaction Time / Q000187:drug effects* / Q000502:physiology
chemical_list: D009292:Narcotic Antagonists; D010936:Plant Extracts; D009020:Morphine; D000432:Methanol