title: Trabeculectomy with mitomycin C in glaucoma associated with uveitis.
abstract: The patients with uveitic glaucoma are at high risk for failure following drainage surgery because of young age of these patients, preoperative long-term control of inflammation and postoperative complications. Twenty-two trabeculectomies performed in 22 patients with uveitic glaucoma were retrospectively evaluated to analyze the effect of intraoperative application of mitomycin C (MMC). Success rates, postoperative levels of intraocular pressure (IOP) and postoperative complications were studied. After a mean follow-up of 10.6 months (range, 5-28 months), 15 patients (68.2%) achieved IOP of 21mmHg or less without antiglaucoma medications. There were statistically significant reduction in IOP postoperatively during the period studied (p < 0.001). Early postoperative complications included chorioidal detachment (9.1%), shallow anterior chamber (9.1%), hyphema (13.6%), macular edema (4.5%) and raised IOP (27.3%). Late postoperative complications included exacerbation of uveitis (4.5%), macular edema (4.5%), cataract (22.7%) and raised IOP (31.8%). The eyes with raised IOP needed additional antiglaucoma medication. The results of this retrospective and uncontrolled study suggest that intraoperative application of MMC may be a good option for enhancement of short-term trabeculectomy success rates in patients with uveitic glaucoma.
authors.affiliation: University Department of Ophthalmology, Clinical Hospital, Systers of Mercy, Zagreb, Croatia.
authors.forename: Katia
authors.initials: K
authors.lastname: Novak-Laus
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Mandić
authors.forename: Renata
authors.initials: R
authors.lastname: Iveković
authors.forename: Jadranka
authors.initials: J
authors.lastname: Korsić
authors.forename: Eugenia
authors.initials: E
authors.lastname: Tedeschi-Reiner
authors.forename: Sanja
authors.initials: S
authors.lastname: Masnec-Paskvalin
authors.forename: Lovro
authors.initials: L
authors.lastname: Bojić
mesh_terms: D000328:Adult; D000963:Antimetabolites / Q000627:therapeutic use*; D017523:Croatia / Q000453:epidemiology; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D014130:Trabeculectomy; D014605:Uveitis / Q000150:complications*
chemical_list: D000963:Antimetabolites; D016685:Mitomycin