Lack of association of CCR gene polymorphisms and left ventricular hypertrophy in essential hypertension.
Left ventricular hypertrophy (LVH) is a major determinant of heart damage. Scientific evidence suggests the influence of genetic factors, but these have yet to be completely clarified. This study investigates a possible relationship between LVH and two chemokine receptor (CCR) gene polymorphisms: CCR5delta32 and CCR264I. Essential hypertensive out-patients (n=118, grade I-II, age 27-54) were recruited from the Catholic University Hypertension Centre. For each subject, clinical data on office blood pressure and M-mode/2D echocardiography were collected. Statistical analysis did not show a significant association between the CCR polymorphisms and LVH in the study population.
Mettimano
M
M
Hypertension Center of the Catholic University Medical School, Rome, Italy. mamettim@tin.it
Specchia
M L
ML
La Torre
G
G
Bruno
A
A
Ricciardi
G
G
Romano-Spica
V
V
Savi
L
L
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019707:Receptors, Chemokine / Q000235:genetics*; D012044:Regression Analysis
D019707:Receptors, Chemokine