title: The effectiveness of calcitonin on chronic back pain and daily activities in postmenopausal women with osteoporosis.
abstract: The aim of this study was to investigate the effect of nasal calcitonin on chronic back pain and disability attributed to osteoporosis. The study design involved three groups of osteoporotic postmenopausal women suffering from chronic back pain. Group I consisted of 40 women with vertebral fractures, group II of 30 women with degenerative disorders and group III of 40 patients with non specific chronic back pain and without abnormality on plain X-rays. Pain intensity was measured using a numerical rating scale (NRS) and disability due to back pain was measured using the Oswestry disability questionnaire. The patients were randomly assigned to receive, for three months, either 200 IU intranasal salmon calcitonin and 1,000 mg of oral calcium daily (groups IA, IIA, IIIA) or 1,000 mg of oral calcium daily (groups IB, IIB, IIIB). Repeated measures ANOVA showed that there were no significant time, group or interaction effects for pain intensity and disability in any of the groups studied. Mean Oswestry and NRS scores were reduced during the follow-up period in the groups IA, IIIA, but the differences between the two time points were not statistically significant. Intranasal calcitonin has no effect on chronic back pain intensity and functional capacity of osteoporotic women regardless of the presence of fractures, degenerative disorders or chronic back pain of non-specific etiology.
authors.affiliation: Department of Orthopaedics and Traumatology, Faculty of Medicine, University of Crete Medical School, Iraklion, Crete 71110, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Papadokostakis
authors.forename: J
authors.initials: J
authors.lastname: Damilakis
authors.forename: E
authors.initials: E
authors.lastname: Mantzouranis
authors.forename: P
authors.initials: P
authors.lastname: Katonis
authors.forename: A
authors.initials: A
authors.lastname: Hadjipavlou
mesh_terms: D000203:Activities of Daily Living; D000281:Administration, Intranasal; D001416:Back Pain / Q000188:drug therapy* / Q000209:etiology; D002116:Calcitonin / Q000008:administration & dosage*; D002118:Calcium / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy*; D010147:Pain Measurement; D020127:Recovery of Function / Q000187:drug effects*; D016103:Spinal Fractures / Q000209:etiology; D013128:Spinal Osteophytosis / Q000188:drug therapy / Q000209:etiology; D013168:Spondylolisthesis / Q000188:drug therapy / Q000209:etiology
chemical_list: D002116:Calcitonin; D002118:Calcium