Production of radioactive particles for endovascular therapeutic interventions.
Recanalization is a common phenomenon that decreases the efficacy of embolization procedures. It can be inhibited by beta-radiation. Two novel ways of producing radioactive particles are described, by neutron beam irradiation of gold-containing microspheres, or by using the 32P binding capacity of zirconium-containing microspheres. Particles were tested in vivo, to assess their ability to deliver radioactivity locally, using canine renal artery, porcine rete mirabile, and rabbit ear embolization models. Both radioactive microspheres (198Au and 32P) showed no detectable activity outside the target territory. 32P microspheres demonstrated typical radiation changes in a porcine rete mirabile arteriovenous malformation model.
Raymond
Jean
J
CHUM Notre-Dame Hospital, 1560 Sherbrooke East, Montreal, Que., Canada H2L 4M1.
Metcalfe
Annick
A
Leblanc
Philippe
P
Salazkin
Igor
I
Papineau
Karl
K
Roy
Daniel
D
Soucy
Jean-Paul
JP
Krom
James A
JA
Schwarz
Alex
A
D000818:Animals; D001165:Arteriovenous Malformations / Q000532:radiotherapy; D021721:Balloon Occlusion; D001672:Biocompatible Materials; D004285:Dogs; D006046:Gold; D006050:Gold Radioisotopes / Q000378:metabolism / Q000627:therapeutic use; D008863:Microspheres; D009501:Neutron Activation Analysis; D010761:Phosphorus Radioisotopes / Q000378:metabolism / Q000627:therapeutic use; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use*; D013552:Swine; D015040:Zirconium
D001672:Biocompatible Materials; D006050:Gold Radioisotopes; D010761:Phosphorus Radioisotopes; D019275:Radiopharmaceuticals; D006046:Gold; D015040:Zirconium