Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.
In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.
Koller
Daniel L
DL
Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA. dkoller@iupui.edu
Alam
Imranul
I
Sun
Qiwei
Q
Liu
Lixiang
L
Fishburn
Tonya
T
Carr
Lucinda G
LG
Econs
Michael J
MJ
Foroud
Tatiana
T
Turner
Charles H
CH
D000818:Animals; D015519:Bone Density / Q000235:genetics*; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D023281:Genomics; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats; D010641:Phenotype; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
D005819:Genetic Markers