title: [Effects of the polysaccharides isolated from ganoderma applanatum (PGA) on the level of PGE2 and gastric mucosal blood flow (GMBF) and gastric mucus secretion of rats with gastric mucosa injury].
abstract: OBJECTIVE
  To investigate the protective effects of the polysaccharides isolated from ganoderma applanatum (PGA) on gastric mucosal injury in rats and the underlying mechanism.
  
  
  METHODS
  Gastric ulcer was induced by either acetic acid or pylorus ligation in the rats. The level of PGE2 and GMBF, and gastric mucus secretion were examined respectively.
  
  
  RESULTS
  After oral administration of PGA (250-1000 mg x kg(-1)) repeatedly, the level of PGE2 and GMBF were obviously increased in gastric mucosa of rats as compared with the model group. The secretions of both free mucus in stomach and mucus of gastric wall were enhanced apparently by PGA in a dose-dependent manner.
  
  
  CONCLUSIONS
  PGA could strengthen gastric mucosa barrier by improving the level of PGE2, GMBF and the secretion of gastric mucus, which may be one of the mechanisms underlying the protective effect of PGA on the gastric mucosa during the gastric ulcer.
authors.affiliation: Department of Pharmacology, Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine and Materia Medica, Changchun 130021, China. yming0918@sina.com
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: De-Wei
authors.initials: DW
authors.lastname: Yu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Cui
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D032902:Ganoderma / Q000737:chemistry; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D009093:Mucus / Q000378:metabolism*; D011134:Polysaccharides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000378:metabolism*
chemical_list: D000897:Anti-Ulcer Agents; D011134:Polysaccharides; D015232:Dinoprostone