Moonlighting vacuolar protease: multiple jobs for a busy protein.
In this Genomics Era with a wealth of annotated sequence data, it is easy to pigeonhole a protein into a particular function. However, Noa Matarasso et al. recently found a vacuolar protease that can also function as a transcription factor. This work illustrates that a protein can serve multiple roles in a cell, raising intriguing questions as to the extent that genomic information can be deciphered de novo.
Rosin
Faye M
FM
Biotech Center, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901, USA.
Watanabe
Naohide
N
Lam
Eric
E
D005030:Ethylenes / Q000096:biosynthesis; D010447:Peptide Hydrolases / Q000378:metabolism*; D010940:Plant Proteins / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D014617:Vacuoles / Q000201:enzymology*
D005030:Ethylenes; D010940:Plant Proteins; D014157:Transcription Factors; C036216:ethylene; D010447:Peptide Hydrolases