title: Gene expression profiling in human cardiovascular disease.
abstract: Gene expression profiling studies in human diseases have allowed better understanding of pathophysiological processes. In addition, they may lead to the development of new clinical tools to improve diagnosis and prognosis of patients. Most of these studies have been successfully performed for human cancers. Inspired by these results, researchers in the cardiovascular field have also started using large-scale transcriptional analysis to better understand and classify human cardiovascular disease. Here we provide an overview of the literature revealing new cardiac disease markers and encouraging results for further development of the expression profiling strategy for future clinical applications in cardiology.
authors.affiliation: L'Institut du Thorax, INSERM U533, Nantes, France. marja.steenman@nantes.inserm.fr
authors.forename: Marja
authors.initials: M
authors.lastname: Steenman
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lamirault
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Le Meur
authors.forename: Jean J
authors.initials: JJ
authors.lastname: Léger
mesh_terms: D020013:Calcium Signaling / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics; D020869:Gene Expression Profiling; D005819:Genetic Markers; D006330:Heart Defects, Congenital / Q000235:genetics; D006333:Heart Failure / Q000235:genetics; D006353:Heart-Assist Devices; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype
chemical_list: D005819:Genetic Markers