Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum.
From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, beta-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, beta-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 microg/ml and showed antiplasmodial activity with an IC50 value of 7.2 microg/ml. Compounds 2 and 3 were inactive in both assays.
Suksamrarn
Apichart
A
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand. apichart@ram1.ru.ac.th
Buaprom
Matee
M
Udtip
Saifon
S
Nuntawong
Nuchnipa
N
Haritakun
Rachada
R
Kanokmedhakul
Somdej
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D029630:Santalaceae / Q000737:chemistry* / Q000145:classification; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D005231:Fatty Acids, Unsaturated; C507470:scleropyric acid