Apolipoprotein E genotype and incident ischemic stroke: the Atherosclerosis Risk in Communities Study.
OBJECTIVE
A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC).


METHODS
The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred.


RESULTS
After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for epsilon2 genotype relative to epsilon3/epsilon3=0.53; 95% CI, 0.28 to 0.99).


CONCLUSIONS
For the most part, in this middle-aged sample, apoE was not a risk factor for incident ischemic stroke.
Sturgeon
Jared D
JD
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Folsom
Aaron R
AR
Bray
Molly S
MS
Boerwinkle
Eric
E
Ballantyne
Christie M
CM
D001057:Apolipoproteins E / Q000235:genetics*; D050197:Atherosclerosis / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007511:Ischemia / Q000235:genetics*; D008055:Lipids / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000235:genetics*; D014652:Vascular Diseases / Q000378:metabolism
D001057:Apolipoproteins E; D008055:Lipids