title: Histologic evaluation of periradicular tissues in dogs treated with calcium hydroxide in combination with HCT20 and camphorated P-chlorophenol.
abstract: OBJECTIVE
  The aim of this study was to evaluate the biocompatibility of calcium hydroxide suspended in HTC20 or calcium hydroxide plus CMCP and their effects on the healing of periapical lesions in dogs.
  
  
  METHODS
  Experimental apical periodontitis was induced by opening the pulp chamber of 36 mandibular premolars in 6 3-year old dogs. The teeth were left opened for 1 week and then closed with IRM for 60 days in order to induce periapical lesions. The teeth were divided into 1 control and 2 experimental groups. Both experimental groups received intracanal dressings with a calcium hydroxide slurry. In the first experimental group calcium hydroxide was mixed with a detergent vehicle and in the second group with camphorated parachlorophenol. The medications were kept in the root canal for 2 periods of 30 days each. Afterwards, the dogs were killed and the periapical areas were studied histologically.
  
  
  RESULTS
  Based on biocompatibility and tissue remodeling in the periapical area, the best results were observed when calcium hydroxide was mixed with the detergent. The difference was statistically significant (P < .05).
  
  
  CONCLUSIONS
  Calcium hydroxide plus CMCP intracanal dressing was the most irritating to the periapical region, and the group of calcium hydroxide plus HCT 20 showed the best results whenever biocompatibility and the capacity of new bone formation was considered.
authors.affiliation: School of Dentistry, Faculty of Health Sciences, University of Brasilia, Brasilia, Brazil. rmcruz@solar.com.br
authors.forename: Roberto Machado
authors.initials: RM
authors.lastname: Cruz
authors.forename: Sergio Valmor
authors.initials: SV
authors.lastname: Barbosa
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000633:toxicity; D001421:Bacteria, Anaerobic / Q000187:drug effects; D001861:Bone Regeneration / Q000187:drug effects; D002126:Calcium Hydroxide / Q000008:administration & dosage*; D002164:Camphor / Q000633:toxicity; D002733:Chlorophenols / Q000633:toxicity; D003902:Detergents / Q000633:toxicity; D004285:Dogs; D004338:Drug Combinations; D010485:Periapical Periodontitis / Q000188:drug therapy*; D010486:Periapical Tissue / Q000187:drug effects*; D014677:Pharmaceutical Vehicles / Q000633:toxicity; D012388:Root Canal Irrigants / Q000008:administration & dosage*; D012967:Sodium Dodecyl Sulfate / Q000633:toxicity; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D002733:Chlorophenols; D003902:Detergents; D004338:Drug Combinations; D014677:Pharmaceutical Vehicles; D012388:Root Canal Irrigants; D012967:Sodium Dodecyl Sulfate; D002164:Camphor; C029804:camphorated parachlorophenol; D002126:Calcium Hydroxide