Subacute cutaneous lupus erythematosus: a paraneoplastic dermatosis?
Subacute cutaneous lupus erythematosus (SCLE) is characterized by clinical, laboratory and immunological features different from those of systemic lupus erythematosus (SLE). We describe the case of a patient with a 2-year history of SCLE that demonstrated a close temporal relationship with a squamous cell malignancy of the head and neck. This association has not been previously reported. We also review the evidence for SCLE as a 'paraneoplastic dermatosis' and discuss the criteria for diagnosis and possible pathogenesis.
Chaudhry
S I
SI
St John's Institute of Dermatology, St Thomas' Hospital, London, UK. sic@globalnet.co.uk
Murphy
L-A
LA
White
I R
IR
D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007822:Laryngeal Neoplasms / Q000150:complications*; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy
D003879:Dermatologic Agents; D006886:Hydroxychloroquine