title: Expression of the UGA4 gene encoding the delta-aminolevulinic and gamma-aminobutyric acids permease in Saccharomyces cerevisiae is controlled by amino acid-sensing systems.
abstract: In yeasts, several sensing systems localized to the plasma membrane which transduce information regarding the availability and quality of nitrogen and carbon sources and work in parallel with the intracellular nutrient-sensing systems, regulate the expression and activity of proteins involved in nutrient uptake and utilization. The aim of this work was to establish whether the cellular signals triggered by amino acids modify the expression of the UGA4 gene which encodes the delta-aminolevulinic (ALA) and gamma-aminobutyric (GABA) acids permease. In the present paper, we demonstrate that extracellular amino acids regulate UGA4 expression and that this effect seems to be mediated by the amino acid sensor complex SPS (SSY1, PTR3, SSY5).
authors.affiliation: Departamento de Química Biológica (FCEyN, UBA), Ciudad Universitaria, Pabellón II, 4th Piso, 1428 Buenos Aires, Argentina. mariana@qb.fcen.uba.ar
authors.forename: Mariana
authors.initials: M
authors.lastname: Bermudez Moretti
authors.forename: Ana Mercedes
authors.initials: AM
authors.lastname: Perullini
authors.forename: Alcira
authors.initials: A
authors.lastname: Batlle
authors.forename: Susana
authors.initials: S
authors.lastname: Correa Garcia
mesh_terms: D026905:Amino Acid Transport Systems / Q000096:biosynthesis* / Q000235:genetics; D000622:Aminolevulinic Acid / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology; D050485:GABA Plasma Membrane Transport Proteins; D015966:Gene Expression Regulation, Fungal; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology; D027361:Organic Anion Transporters / Q000096:biosynthesis* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D050485:GABA Plasma Membrane Transport Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D027361:Organic Anion Transporters; C106976:PTR3 protein, S cerevisiae; C120527:SSY1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C513599:UGA4 protein, S cerevisiae; D005680:gamma-Aminobutyric Acid; D000622:Aminolevulinic Acid