Inhibition of lipid droplet accumulation in macrophages by triterpenoids produced from Torametes orientaris.
Four triterpenoids 1-4 isolated from the fruit body of Torametes orientaris were found to inhibit lipid droplet accumulation in macrophages. From the biochemical analysis, compounds 2 and 3 inhibited selectively cholesteryl ester synthesis in macrophages, while compounds 1 and 4 showed inhibition of both cholesteryl ester and triacylglycerol syntheses.
Ohshiro
Taichi
T
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University; Tokyo 108-8641, Japan.
Namatame
Ichiji
I
Ochiai
Kana
K
Kawagishi
Hirokazu
H
Tomoda
Hiroshi
H
D000818:Animals; D002788:Cholesterol Esters / Q000096:biosynthesis; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000737:chemistry*; D050356:Lipid Metabolism; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D014280:Triglycerides / Q000096:biosynthesis; D014315:Triterpenes / Q000378:metabolism / Q000494:pharmacology*
D002788:Cholesterol Esters; D014280:Triglycerides; D014315:Triterpenes