title: MR imaging of patients with localisation-related seizures: initial experience at 3.0T and relevance to the NICE guidelines.
abstract: The purpose of this study is to describe our initial experience of imaging adults with localisation-related epilepsy using MR imaging at 3.0T. We discuss the findings in the context of the recently released NICE guidelines that provide detailed advice on imaging people with epilepsy in the UK. 120 consecutive people over the age of 16 years with localisation-related epilepsy were referred for clinical MR examinations from a regional neuroscience centre in England. None of the people had had MR examinations prior to the present study. High resolution MR imaging was performed taking advantage of the high field strength and high performance gradients of the system. Two experienced neuroradiologists reported on the examinations independently and the presence and type of pathology was recorded. There was complete agreement between the two reporters in all 120 cases. The overall frequency of abnormalities shown by MR was 31/120 (26%) and the commonest abnormality shown was mesial temporal sclerosis found in 10/120 (8%). Tumours were shown in 4/120, all of which appeared low grade as judged by imaging criteria. Epilepsy is the commonest neurological condition and demands a significant resource in order to provide good care for sufferers. Recent guidelines published in the UK have suggested that the majority of people with epilepsy should receive brain MR as part of their routine assessment. Our work shows that using the most sophisticated MR imaging in a highly selected population there is a modest pick-up rate of brain abnormalities. If a widespread epilepsy-imaging programme is started the detection rate is likely to be much lower. Although MR is acknowledged to be a reliable way of detecting pathology in people with epilepsy there is a dearth of information studying the health economics of imaging epilepsy in relation to patient management and outcomes.
authors.affiliation: Section of Radiology, University of Sheffield, Sheffield, UK. p.griffiths@sheffield.ac.uk
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
authors.forename: S C
authors.initials: SC
authors.lastname: Coley
authors.forename: D J A
authors.initials: DJ
authors.lastname: Connolly
authors.forename: T
authors.initials: T
authors.lastname: Hodgson
authors.forename: C A J
authors.initials: CA
authors.lastname: Romanowski
authors.forename: E
authors.initials: E
authors.lastname: Widjaja
authors.forename: G
authors.initials: G
authors.lastname: Darwent
authors.forename: I D
authors.initials: ID
authors.lastname: Wilkinson
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis*; D004828:Epilepsies, Partial / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies