title: Asynchronous burst-suppression in a child with callosal Ki-1 anaplastic large cell lymphoma.
abstract: A 13-year-old girl with Ki-1 anaplastic large cell lymphoma (Ki-1ALCL) bulky deposits in the brain developed raised intracranial pressure and coma associated with asynchronous burst-suppression following standard dose cranial irradiation. Supportive care, steroids, and chemotherapy resulted in clinical improvement. Burst-suppression coma may be reversible when secondary to tumor, decrease in steroids, or radiation effects; the asynchrony localizes the lesion to cortical interconnections such as the corpus callosum.
authors.affiliation: Division of Neurology, British Columbia's Children's Hospital, University of British Columbia, Canada. jhukin@cw.bc.ca
authors.forename: J
authors.initials: J
authors.lastname: Hukin
authors.forename: A
authors.initials: A
authors.lastname: Davey
authors.forename: P
authors.initials: P
authors.lastname: Wong
authors.forename: G
authors.initials: G
authors.lastname: Hendson
authors.forename: C
authors.initials: C
authors.lastname: Aquino-Parsons
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Sargent
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000556:secondary; D003128:Coma / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology; D008206:Lymphatic Diseases / Q000150:complications; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009433:Neural Inhibition / Q000187:drug effects / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D013163:Splenomegaly / Q000150:complications; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone