title: Malignant prolactinoma with multiple bone and pulmonary metastases. Case report.
abstract: Malignant prolactinomas, as with other pituitary carcinomas, are rare tumors. The authors describe a 14-year-old boy who presented with visual loss caused by a pituitary prolactinoma. He underwent transsphenoidal surgery, radiotherapy, and dopamine agonist therapy, but 6 years after the initial diagnosis his pituitary tumor regrew and bone and pulmonary metastases developed. The authors review the literature and discuss the clinical presentation of malignant prolactinomas, their rarity, histological characteristics, distribution of the metastases, different treatment approaches, and their poor prognosis.
authors.affiliation: Department of Endocrinology, Hospital Universitario Puerta de Hierro, Madrid, Spain. cristinalamas72@hotmail.com
authors.forename: Cristina
authors.initials: C
authors.lastname: Lamas
authors.forename: Raúl
authors.initials: R
authors.lastname: Núñez
authors.forename: José
authors.initials: J
authors.lastname: García-Uría
authors.forename: Clara
authors.initials: C
authors.lastname: Salas
authors.forename: Gertrudis
authors.initials: G
authors.lastname: Saucedo
authors.forename: Javier
authors.initials: J
authors.lastname: Estrada
authors.forename: Avelino
authors.initials: A
authors.lastname: Parajón
authors.forename: Tomás
authors.initials: T
authors.lastname: Lucas
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000556:secondary*; D018491:Dopamine Agonists / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D015175:Prolactinoma / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D014786:Vision Disorders / Q000209:etiology
chemical_list: D018491:Dopamine Agonists