[The impact of Glut-1 marker application on the diagnosis and treatment of congenital vascular anomalies].
Hemangiomas of infancy have a unique vascular phenotype demonstrated by glucose transporter 1 (GLUT-1) staining marker. Since its first description by P. E. North in 2000 its use has become widely spread by clinicians and researchers in the field of vascular anomalies. We prospectively and retrospectively used GLUT-1 marker on 90 patients divided in five groups over a two years period. Grupo I: Hemangiomas under 1 year of age. Grupo II: Hemangiomas between 1 and 15 years of age. Grupo III: Misdiagnosed angiomas in patients older than 15 years. Grupo IV: Patients with low and high flow vascular malformations Grupo V: Vascular tumors other than hemangiomas. As a result of the study, significant improvement has been noticed by the authors in appropiate vascular anomalies classification by primary care physicians involved in the study. Angioma is not anymore synonym of vascular birthmark. In addition the management of the newborn with a vascular tumour benefit from a more appropriate antiangiogenic therapy. Patients with RICH (rapidly involuting congenital hemangioma) or NICH (non involuting congenital hemangioma) pattern after biopsy and inmunohistochemical study did not receive any pharmacological agent as a part of their treatment. Finally GLUT-1 helped multidisciplinary vascular anomalies team development by promoting clinical, radiological and histopathologic correlations between different specialists.
López Gutiérrez
J C
JC
Departamento de Cirugía Pediátrica, Hospital La Paz, Madrid.
Tovar
J A
JA
Patrón
M
M
D000293:Adolescent; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D051272:Glucose Transporter Type 1 / Q000235:genetics*; D018324:Hemangioma, Capillary / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007223:Infant; D008967:Molecular Biology / Q000379:methods; D010641:Phenotype; D011446:Prospective Studies; D012189:Retrospective Studies; D019043:Vascular Neoplasms / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy
D020533:Angiogenesis Inhibitors; D051272:Glucose Transporter Type 1