title: [Predictive modeling of circulatory response to spinal anesthesia].
abstract: Based on the parallels between regional and systemic vasodilation, the authors examined the capacities of the sublingual nitroglycerin (500 microg) test in the predictive simulation of an individual circulatory response to subarachnoidal blockage. The integral body rheography technique developed by M. I. Tishchenko, involving signal processing in real time, was used to study the pump function of the left ventricle (LV). Assessment of the time course of changes in the latter in response to the test and blockade has established that hemodynamic stability is maintained in both cases, by increasing the LV output and capacity. Risk factors of the development of significant arterial hypotension resulting from spinal blockade could be revealed. Among them there were changes in the LV capacity index, which proved to be of the most informative value. The study has allowed the authors to develop a predictive test that is noted for its non-invasiveness and simplicity.
authors.forename: K M
authors.initials: KM
authors.lastname: Lebedinskiĭ
authors.forename: D A
authors.initials: DA
authors.lastname: Shevkulenko
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000494:pharmacology; D010992:Plethysmography, Impedance; D011237:Predictive Value of Tests; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin