Recent advances in non-peptidic RANTES antagonists.
RANTES is a member of a large family of cytokines, called chemokines, which are thought to play a regulatory role in leukocyte recruitment and inflammatory processes. The involvement of RANTES in diseases is now well documented and proved using antibody and peptide inhibitors. Non-peptidic RANTES antagonists, which have recently started to appear in the literature, will be reviewed.
Halley
F
F
Rhône-Poulenc Rorer, Dagenham Research Centre, Dagenham, Essex, RM10 7XS, UK. frank.halley@rp-rorer.co.uk