[Effects of octreotide on implanted liver tumor after partial hepatectomy in rats].
OBJECTIVE
To investigate the effects of octreotide(OCT) on experimental live tumor after partial hepatectomy (PH) in rats and explore its intrinsic mechanism.


METHODS
Sixty-four male rats were randomly divided into four groups and operated on with laparotomy. Walker-256 tumor was implanted in all the four groups. Group A served as the control, and groups B, C and D received left lobe PH. Octreotide at a dose of 50 microg/kg was intraperitoneally (i.p.) administered twice a day in groups C and D (OCT). The time of the first administration was at the 12th hour after PH in group C and the 72nd hour after PH in group D. The rats in groups A and B received a similar volume of normal saline (NS).


RESULTS
Group A showed a significant reduction of implanted liver tumor volume at the 7th day versus group B (P < 0.01). Groups C and D showed a significant reduction of tumor volume at the 7th and 15th day versus group B (P < 0.01). The tumor cell apoptotic rate was significantly higher in groups C and D than in groups A and B at the 7th and 15th day (P < 0.01).


CONCLUSIONS
The growth of experimental liver tumor is enhanced after PH bat can be inhibited by OCT.
Xu
G
G
Department of General Surgery, Anhui Provincial People's Hospital, Hefei 230001, China.
Yi
S
S
Xu
R
R
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D006498:Hepatectomy / Q000009:adverse effects; D007274:Injections, Intraperitoneal; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D009366:Neoplasm Seeding; D015282:Octreotide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide