Recognition of guanines at a double helix-coil junction in DNA by a trinuclear copper complex.
Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix-coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.
Ito
Takeo
T
Department of Chemistry and Biochemistry, University of Maryland, College Park, 20742, USA.
Thyagarajan
Sunita
S
Karlin
Kenneth D
KD
Rokita
Steven E
SE
D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
D009942:Organometallic Compounds; D006147:Guanine; D003300:Copper; D004247:DNA