[Establishment of a novel arrhythmia model in rats].
OBJECTIVE
To establish a novel arrhythmia model in rats.


METHODS
Coronary artery occlusion was produced in hyperlipidemic rats after the animals were fed a high fat and cholesterol chow for 15 days. The incidence, duration and score of arrhythmias were determined 1 hour after coronary occlusion.


RESULTS
The incidence, duration and score of arrhythmia induced by coronary artery occlusion increased significantly in hyperlipidemic rats compared with those in normal rats (P < 0.05). In normal rats, pretreatment with amiodarone 60 mg x kg(-1) or verapamil 25 mg x kg(-1) 3 days before coronary artery occlusion did not influence the incidence, duration and score of arrhythmia (P > 0.05). In hyperlipidemic rats, amiodarone 60 mg x kg(-1) decreased the incidence, duration and score of arrhythmia (P < 0.05), but not verapamil 25 mg x kg(-1) (P > 0.05).


CONCLUSIONS
The novel arrhythmia model induced by coronary artery occlusion in hyperlipidemic rats is reliable and similar to the pathophysiological state in human being.
Pan
Zhen-Wei
ZW
Department of Pharmacology, Harbin Medical University, Bio-pharmaceutical Key Laboratory of Heilongjiang Province, China.
Wang
Zhi-Yong
ZY
Du
Zhi-Min
ZM
Jiao
Jun-Dong
JD
Dong
De-Li
DL
Yang
Bao-Feng
BF
D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications*; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000150:complications*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone