Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.
A series of novel 4,2-bisheterocycle tandem derivatives consisting of a methyloxazole and thiazole subunit were synthesized. Many compounds were found to inhibit human influenza A virus. Several analogues exhibited moderate biological activity and could serve as leads for further optimizations for antivirus research.
Wang
Wen-Long
WL
Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes of Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Shanghai 201203, China.
Yao
De-Yong
DY
Gu
Min
M
Fan
Min-Zhi
MZ
Li
Jing-Ya
JY
Xing
Ya-Cheng
YC
Nan
Fa-Jun
FJ
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D029521:Alphainfluenzavirus / Q000187:drug effects*; D010080:Oxazoles / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
D000998:Antiviral Agents; D010080:Oxazoles; D013844:Thiazoles