title: Growth retardation and bilateral cataracts followed by anaplastic meningioma 23 years after high-dose cranial and whole-body irradiation for acute lymphoblastic leukemia: case report and review of the literature.
abstract: We report a case of meningioma diagnosed 23 years after high-dose cranial and whole-body irradiation for the treatment of acute lymphocytic leukemia (ALL). Radiotherapy in this case also caused early radiation injury to the lenses and the pituitary gland, with growth retardation and mineralizing angiopathy. Radiation-induced meningiomas are more commonly malignant, more commonly multiple, and more likely to recur after resection than non-radiation-induced meningiomas. Survivors of childhood ALL treated with high-dose cranial irradiation are at risk both for early radiation injury in radiosensitive organs, such as the lens and pituitary gland, and for the later development of a radiation-induced meningioma.
authors.affiliation: Department of Neurosurgery, University Greifswald, Sauerbruchstrasse, 17487 Greifswald, Germany. alexeikorenkov@aol.com
authors.forename: Alexei I
authors.initials: AI
authors.lastname: Korenkov
authors.forename: Hans G
authors.initials: HG
authors.lastname: Imhof
authors.forename: Sebastian
authors.initials: S
authors.lastname: Brandner
authors.forename: Ethan
authors.initials: E
authors.lastname: Taub
authors.forename: Pia U
authors.initials: PU
authors.lastname: Huguenin
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gaab
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yonekawa
mesh_terms: D000328:Adult; D002386:Cataract / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D016371:Cranial Irradiation / Q000009:adverse effects*; D006130:Growth Disorders / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007908:Lens, Crystalline / Q000528:radiation effects; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D010902:Pituitary Gland / Q000528:radiation effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014916:Whole-Body Irradiation