Hypotensive activity, toxicology and histopathology of opuntioside-I and methanolic extract of Opuntia dillenii.
Methanolic extract of Opuntia dillenii cladodes and its pure compound alpha-pyrone glycoside, opuntioside-I showed potent hypotensive activity in normotensive rats. Both the extract and opuntioside-I showed comparable effect of 44-54% fall in Mean Arterial Blood Pressure (MABP) at the dose of 10 mg/kg. No mortality was observed in rats even at the doses of 1000 mg/kg/d and 900 mg/kg/d per oral of extract and opuntioside-I respectively. However, histopathology revealed adverse effects of high doses on liver and spleen of the experimental animals.
Saleem
Rubeena
R
Faculty of Pharmacy, Hamdard University; Karachi, Pakistan. rs127pk@yahoo.com
Ahmad
Mohammad
M
Azmat
Aisha
A
Ahmad
Syed Iqbal
SI
Faizi
Zareen
Z
Abidi
Lubna
L
Faizi
Shaheen
S
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000633:toxicity; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D009005:Monosaccharides / Q000494:pharmacology* / Q000633:toxicity; D029747:Opuntia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D000959:Antihypertensive Agents; D001786:Blood Glucose; D001798:Blood Proteins; D009005:Monosaccharides; D010936:Plant Extracts; C507579:opuntioside-I; D002784:Cholesterol; D001663:Bilirubin