Identification of large ancient duplications associated with human gene deserts.
We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.
Itoh
Takehiko
T
Research Center for Advanced Science and Technology, Mitsubishi Research Institute, Inc., Tokyo 100-8141, Japan. takehiko@mri.co.jp
Toyoda
Atsushi
A
Taylor
Todd D
TD
Sakaki
Yoshiyuki
Y
Hattori
Masahira
M
D000818:Animals; D004285:Dogs; D019143:Evolution, Molecular; D020440:Gene Duplication; D020131:Genes, Duplicate / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D051379:Mice