A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.
Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.
Tempeam
Atchara
A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Thasana
Nopporn
N
Pavaro
Chitkavee
C
Chuakul
Wongsatit
W
Siripong
Pongpun
P
Ruchirawat
Somsak
S
D002247:Carbon Isotopes; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry* / Q000145:classification; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy / Q000379:methods / Q000592:standards; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D011522:Protons; D012015:Reference Standards; D013237:Stereoisomerism
D002247:Carbon Isotopes; D004224:Diterpenes; D018942:Macrolides; D011522:Protons; C483695:rediocide A; C507469:rediocide G