The effect of ethambutol on mycobacterial cell wall permeability to hydrophobic compounds.
Ethambutol (EMB), the first line drug in the treatment of tuberculosis, is an inhibitor of the biosynthesis of the cell wall compound - arabinogalactan. It was found that EMB at sub-inhibitory concentration increases the permeability of the M. vaccae cell wall, which was monitored by cell sensitization to erythromycin and rifampicin. The high permeability of the cell wall to hydrophobic compounds allows enhanced intracellular bioconversion of beta-sitosterol to 4-androsten-3,17-dione (AD) and 1,4-androstadien-3,17-dione (ADD).
Korycka-Machała
Małgorzata
M
Centre for Medical Biology, Polish Academy of Sciences, 93-232 Lódź, Lodowa 106, Poland.
Rumijowska-Galewicz
Anna
A
Dziadek
Jarosław
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002473:Cell Wall / Q000737:chemistry / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology; D004977:Ethambutol / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology; D012855:Sitosterols / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D012855:Sitosterols; D004917:Erythromycin; D004977:Ethambutol; D012293:Rifampin