Gastrointestinal transit and disintegration of enteric coated magnetic tablets assessed by ac biosusceptometry.
The oral administration is a common route in the drug therapy and the solid pharmaceutical forms are widely used. Although much about the performance of these formulations can be learned from in vitro studies using conventional methods, evaluation in vivo is essential in product development. The knowledge of the gastrointestinal transit and how the physiological variables can interfere with the disintegration and drug absorption is a prerequisite for development of dosage forms. The aim of this work was to employing the ac biosusceptometry (ACB) to monitoring magnetic tablets in the human gastrointestinal tract and to obtain the magnetic images of the disintegration process in the colonic region. The ac biosusceptometry showed accuracy in the quantification of the gastric residence time, the intestinal transit time and the disintegration time (DT) of the magnetic formulations in the human gastrointestinal tract. Moreover, ac biosusceptometry is a non-invasive technique, radiation-free and harmless to the volunteers, as well as an important research tool in the pharmaceutical, pharmacological and physiological investigations.
Corá
Luciana A
LA
Department of Physics and Biophysics, Biosciences Institute, IBB, Laboratório de Biomagnetismo, Universidade Estadual Paulista, CXP 510, Rua Botucatu, São Paulo CEP 18618-000, Brazil.
Romeiro
Fernando G
FG
Américo
Madileine F
MF
Oliveira
Ricardo Brandt
RB
Baffa
Oswaldo
O
Stelzer
Murilo
M
Miranda
José Ricardo de Arruda
JR
D000284:Administration, Oral; D000328:Adult; D015374:Biosensing Techniques; D003106:Colon / Q000737:chemistry / Q000502:physiology; D016503:Drug Delivery Systems; D005260:Female; D005290:Ferric Compounds; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D008280:Magnetics / Q000295:instrumentation*; D008297:Male; D016065:Myoelectric Complex, Migrating; D012995:Solubility; D013270:Stomach / Q000737:chemistry / Q000502:physiology; D013608:Tablets, Enteric-Coated / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D013997:Time Factors
D005290:Ferric Compounds; D013608:Tablets, Enteric-Coated; C001215:ferrite