title: Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.
abstract: In humans, peak bone mineral density (BMD) is the primary determinant of osteoporotic fracture risk among older individuals, with high peak BMD levels providing protection against osteoporosis in the almost certain event of bone loss later in life. A genome screen to identify quantitative trait loci (QTLs) contributing to areal BMD (aBMD) and volumetric BMD (vBMD) measurements at the lumbar spine and femoral neck was completed in 595 female F2 rats produced from reciprocal crosses of inbred Fischer 344 and Lewis rats. Significant evidence of linkage was detected to rat Chromosomes 1, 2, 8, and 10, with LOD scores above 8.0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women.
authors.affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA. dkoller@iupui.edu
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Koller
authors.forename: Imranul
authors.initials: I
authors.lastname: Alam
authors.forename: Qiwei
authors.initials: Q
authors.lastname: Sun
authors.forename: Lixiang
authors.initials: L
authors.lastname: Liu
authors.forename: Tonya
authors.initials: T
authors.lastname: Fishburn
authors.forename: Lucinda G
authors.initials: LG
authors.lastname: Carr
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Econs
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Charles H
authors.initials: CH
authors.lastname: Turner
mesh_terms: D000818:Animals; D015519:Bone Density / Q000235:genetics*; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D023281:Genomics; D006801:Humans; D008126:Lod Score; D018895:Microsatellite Repeats; D010641:Phenotype; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
chemical_list: D005819:Genetic Markers