title: Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan.
abstract: A prospective study was carried out in an area of unstable malaria transmission in central Sudan to determine the efficacy and toxicity of quinine in pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum malaria at mean 28.8 weeks gestational age were treated with quinine for 7 days. The mean body temperature on presentation for 3 patients who delivered prematurely was significantly higher than for those who delivered at term (39.2 +/- 0.7 degrees C versus 38.7 +/- 1.3 degrees C). There were no significant difference between the 2 groups in other clinical or biochemical parameters. There were no clinically detectable congenital malformations and no auditory, visual or other neurological deficits in the babies at birth or 6 months later. Quinine may be safe in the treatment of severe falciparum malaria during pregnancy.
authors.affiliation: New Halfa Hospital, New Halfa, Sudan.
authors.forename: I
authors.initials: I
authors.lastname: Adam
authors.forename: O A
authors.initials: OA
authors.lastname: Mirghani
authors.forename: O K
authors.initials: OK
authors.lastname: Saed
authors.forename: S M
authors.initials: SM
authors.lastname: Ahmed
authors.forename: A A
authors.initials: AA
authors.lastname: Mohamadani
authors.forename: H M
authors.initials: HM
authors.lastname: Ahmed
authors.forename: C D
authors.initials: CD
authors.lastname: Mackenzie
authors.forename: M M A
authors.initials: MM
authors.lastname: Homeida
authors.forename: M I
authors.initials: MI
authors.lastname: Elbashir
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D001831:Body Temperature; D004334:Drug Administration Schedule; D005260:Female; D005865:Gestational Age; D006801:Humans; D007262:Infusions, Intravenous; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy* / Q000453:epidemiology; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D011446:Prospective Studies; D011803:Quinine / Q000627:therapeutic use*; D012449:Safety; D012621:Seasons; D012720:Severity of Illness Index; D013397:Sudan / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D011803:Quinine