Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex.
The shoot apical meristem (SAM) is a collection of stem cells that resides at the tip of each shoot and provides the cells of the shoot. It is divided into functional regions. The central zone (CZ) at the tip of the meristem is the domain of expression of the CLAVATA3 (CLV3) gene, encoding a putative ligand for a transmembrane receptor kinase, CLAVATA1, active in cells of the rib meristem (RM), located just below the CZ. We show here that CLV3 restricts its own domain of expression (the CZ) by preventing differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ cells and restricts overall SAM size by a separate, long-range effect on cell division rate.
Reddy
G Venugopala
GV
California Institute of Technology, Division of Biology, MC 156-29, 1200 East California Boulevard, Pasadena, CA 91125, USA.
Meyerowitz
Elliot M
EM
D017360:Arabidopsis / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003907:Dexamethasone / Q000494:pharmacology; D015870:Gene Expression; D020868:Gene Silencing; D006706:Homeostasis; D018519:Meristem / Q000166:cytology / Q000254:growth & development*; D030821:Plants, Genetically Modified; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology*
C118167:AT2G27250 protein, Arabidopsis; D029681:Arabidopsis Proteins; D003907:Dexamethasone