Cell cycle-related protein expression in Alzheimer's disease and vascular disease.
The link between Alzheimer's disease and cerebrovascular disease has been long recognized. However, the mechanisms that lead to the development of the two seemingly different pathologies are still elusive. Our studies concentrate on the understanding of the interaction between the two diseases and the deciphering of a possible common pathogenic mechanism. In this context the role of shared risk factors, such as ApoE and elevated plasma homocysteine, is also discussed.
Nagy
Zsuzsanna
Z
OPTIMA, University of Oxford, Oxford, UK. zsuzsa.nagy@pharm.ox.ac.uk
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D017209:Apoptosis / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000235:genetics*; D006710:Homocysteine / Q000235:genetics*; D006801:Humans
D001057:Apolipoproteins E; D006710:Homocysteine