title: Are clips useful in the surgical repair of colonic perforations?
abstract: OBJECTIVE
  The objective of this study was to assess the effecacy of clip application in the surgical repair of iatrogenic colonic perforations.
  
  
  METHODS
  Twenty adult male Wistar-Albino rats were divided into two equal groups of ten. In both of the groups an iatrogenic perforation was made in the anti-mesenteric border of the left colon. The defect was closed with interrupted 6/0 polypropylene sutures in group 1 and extraluminal application of vascular clips (VCS--vascular clip system) in group 2. All animals were killed on postoperative Day 4. Wound healing was evaluated with both in situ bursting pressure and hydroxyproline levels.
  
  
  RESULTS
  There was no statistically significant difference between the two groups in respect of bursting pressure levels (p = 0.063) whereas hydroxyproline levels were higher in group 2 (p = 0.0021).
  
  
  CONCLUSIONS
  Surgical repair of iatrogenic colonic perforations by extraluminal clips gives comparable results according to wound healing parameters. This approach may be a rational alternative to suture or endoscopic repair methods.
authors.affiliation: Haydarpasa Numune Training and Research Hospital, Department of General Surgery.
authors.forename: E
authors.initials: E
authors.lastname: Altinli
authors.forename: K
authors.initials: K
authors.lastname: Saribeyoğlu
authors.forename: T
authors.initials: T
authors.lastname: Karahasanoğlu
authors.forename: I
authors.initials: I
authors.lastname: Hamzaoğlu
authors.forename: F
authors.initials: F
authors.lastname: Aydoğan
authors.forename: I
authors.initials: I
authors.lastname: Karabiçak
authors.forename: K
authors.initials: K
authors.lastname: Alemdaroğlu
mesh_terms: D000818:Animals; D003106:Colon / Q000293:injuries* / Q000601:surgery*; D006909:Hydroxyproline / Q000032:analysis; D007049:Iatrogenic Disease; D007416:Intestinal Perforation / Q000601:surgery*; D008297:Male; D011126:Polypropylenes; D051381:Rats; D017208:Rats, Wistar; D013525:Surgical Instruments; D013537:Sutures; D014945:Wound Healing
chemical_list: D011126:Polypropylenes; D006909:Hydroxyproline