[Sex-related differences in the antinociceptive effect of some non-narcotic analgetics in rats: the role of biotransformation].
Non-narcotic analgetics sodium diclofenac, indomethacin, naproxen, nimesulid, ketorolac, and celebrex (cytochrome P-450(2)c substrates) produce more pronounced and prolonged analgesic effect in pubertate female rats than in males. This can be related to the slower elimination of drugs from the female organism. The liver of females is characterized by a lower content of cytochrome P-450 and by less pronounced activity of amidopyrine-N-, indomethacin-O-, and naproxen-O-demethylase activity. No sex-related differences in pharmacodynamics were observed for meloxicam, and ethoricoxib, benzofurocaine, and amison, and acetylsalicylic acid, which are the substrates predominantly for CYP3A.
Voloshchuk
N I
NI
Pentiuk
A A
AA
Durnev
A D
AD
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001711:Biotransformation; D051544:Cytochrome P-450 CYP3A / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008099:Liver / Q000201:enzymology; D008297:Male; D010089:Oxidoreductases, N-Demethylating / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012737:Sex Factors
D018712:Analgesics, Non-Narcotic; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating