title: Mitochondria: pharmacological manipulation of cell death.
abstract: Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.
authors.affiliation: La Jolla Institute for Allergy and Immunology, Department of Cellular Immunology, San Diego, California 92121, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Bouchier-Hayes
authors.forename: Lydia
authors.initials: L
authors.lastname: Lartigue
authors.forename: Donald D
authors.initials: DD
authors.lastname: Newmeyer
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D015195:Drug Design; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: D004364:Pharmaceutical Preparations