title: [The clinical consequences of changes occurring in HCV population during the first weeks of chronic hepatitis C treatment with interferon and ribavirin].
abstract: Hepatitis C virus (HCV) is an extremely dangerous human pathogen. It is widespread all over the world and often leads to the development of chronic hepatitis C (CHC), which can eventually result in cirrhosis a hepatocellular carcinoma. The efficiency of the current applied methods of treatment of HCV infection remains unsatisfactory. The main course of development of CHC and of therapeutic problems is the genetic polymorphism of HCV. The conducted analysis of the structure of the virus' population permits are conclude that the degree of diversity it presents is a crucial agent in the prediction of the outcome of IFN and ribavirin therapy.
authors.affiliation: Klinika Chorób Zakaźnych i Neurologii Dzieciecej, Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu. mfiglerowicz@sk5.usoms.poznan.pl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Figlerowicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Formanowicz
authors.forename: Paweł
authors.initials: P
authors.lastname: Kedziora
authors.forename: Magdalena
authors.initials: M
authors.lastname: Alejska
authors.forename: Paulina
authors.initials: P
authors.lastname: Jackowiak
authors.forename: Jacek
authors.initials: J
authors.lastname: Błazewicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Słuzewski
authors.forename: Marek
authors.initials: M
authors.lastname: Figlerowicz
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology / Q000627:therapeutic use*; D011110:Polymorphism, Genetic; D011379:Prognosis; D011994:Recombinant Proteins; D012254:Ribavirin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin