Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Electrospray ionization quadrupole time-of-flight (ESI-QqToF) mass spectra of naltrindole hydrochloride 1, naltriben mesylate 2, and naltrexone hydrochloride 3, a common series of morphine opiate receptor antagonists, were recorded using different declustering potentials. Low-energy collision-induced dissociation (CID) MS/MS experiments established the fragmentation routes of these compounds. In addition, re-confirmation of the various established fragmentation routes was effected by conducting a series of ESI-CID-QqTof-MS/MS experiments using non-conventional quasi MS(n) (up to MS8) product ion scans, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. Precursor ion scan analyses were also performed with a conventional quadrupole-hexapole-quadrupole tandem mass spectrometer and allowed the confirmation of the genesis of some diagnostic ions.
Joly
Nicolas
N
Laboratoire de le Barrière Hémato-Encéphalique, E.A. 2465, Département de Chimie, Université d'Artois, Béthune, France.
El Aneed
Anas
A
Martin
Patrick
P
Cecchelli
Roméo
R
Banoub
Joseph
J
D008698:Mesylates / Q000737:chemistry; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D009292:Narcotic Antagonists / Q000032:analysis*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D008698:Mesylates; D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; C068868:naltrindole benzofuran; D009271:Naltrexone; C055382:naltrindole