Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan.
A prospective study was carried out in an area of unstable malaria transmission in central Sudan to determine the efficacy and toxicity of quinine in pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum malaria at mean 28.8 weeks gestational age were treated with quinine for 7 days. The mean body temperature on presentation for 3 patients who delivered prematurely was significantly higher than for those who delivered at term (39.2 +/- 0.7 degrees C versus 38.7 +/- 1.3 degrees C). There were no significant difference between the 2 groups in other clinical or biochemical parameters. There were no clinically detectable congenital malformations and no auditory, visual or other neurological deficits in the babies at birth or 6 months later. Quinine may be safe in the treatment of severe falciparum malaria during pregnancy.
Adam
I
I
New Halfa Hospital, New Halfa, Sudan.
Mirghani
O A
OA
Saed
O K
OK
Ahmed
S M
SM
Mohamadani
A A
AA
Ahmed
H M
HM
Mackenzie
C D
CD
Homeida
M M A
MM
Elbashir
M I
MI
D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D001831:Body Temperature; D004334:Drug Administration Schedule; D005260:Female; D005865:Gestational Age; D006801:Humans; D007262:Infusions, Intravenous; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy* / Q000453:epidemiology; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D011446:Prospective Studies; D011803:Quinine / Q000627:therapeutic use*; D012449:Safety; D012621:Seasons; D012720:Severity of Illness Index; D013397:Sudan / Q000453:epidemiology; D016896:Treatment Outcome
D000962:Antimalarials; D011803:Quinine