Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by chlormadinone acetate in cultured human lymphocytes.
In our present study, different doses of allicin and L-ascorbic acid were tested against the genotoxic damage induced by chlormadinone acetate (CMA; 40 microM) using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) as the parameters. Treatment with allicin and L-ascorbic acid resulted in reduction of CAs and SCEs. The results suggested a protective role of allicin and L-ascorbic acid against CMA induced genotoxic damage.
Siddique
Yasir Hasan
YH
Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202 002, India. yasir_hasansiddique@rediffmail.com
Afzal
Mohammad
M
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002478:Cells, Cultured; D002715:Chlormadinone Acetate / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004220:Disulfides; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008956:Models, Chemical; D012854:Sister Chromatid Exchange; D013441:Sulfinic Acids / Q000494:pharmacology*; D013997:Time Factors
D000890:Anti-Infective Agents; D004220:Disulfides; D016166:Free Radical Scavengers; D013441:Sulfinic Acids; D002715:Chlormadinone Acetate; C006452:allicin; D001205:Ascorbic Acid