Plasticity in the injured spinal cord: can we use it to advantage to reestablish effective bladder voiding and continence?
Micturition is coordinated at the level of the spinal cord and the brainstem. Spinal cord injury therefore directly interrupts spinal neuronal pathways to the brainstem and results in bladder areflexia. Some time after injury, however, dyssynergic bladder and sphincter function emerges. The changes mediating the appearance of bladder function after spinal cord injury are currently unknown. Primary afferent neurons have been shown to sprout in response to spinal cord injury. Sprouting primary afferents have been linked to the pathophysiology of centrally manifested disorders, such as autonomic dysreflexia and neuropathic pain. It is proposed that sprouting of bladder primary afferents contributes to disordered bladder functioning after spinal cord injury. During development of the central nervous system, the levels of specific neuronal growth-promoting and guidance molecules are high. After spinal cord injury, some of these molecules are upregulated in the bladder and spinal cord, suggesting that axonal outgrowth is occurring. Sprouting in lumbosacral spinal cord is likely not restricted to neurons involved in the micturition reflex. Furthermore, sprouting of some afferents may be contributing to bladder function after injury, whereas sprouting of others might be hindering emergence of function. Thus selective manipulation of sprouting targeting afferents that are contributing to emergence of bladder function after injury is critical. Further research regarding the role that neuronal sprouting plays in the emergence of bladder function may contribute to improved treatment of bladder dyssynergia after spinal cord injury.
Zinck
Natasha D T
ND
Department of Pharmacology, Faculty of Medicine, Dalhousie University, 5850 College St., Halifax, NS B3H 1X5, Canada. nzinck@dal.ca
Downie
John W
JW
D000344:Afferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D001369:Axons / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D007395:Interneurons / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D020932:Nerve Growth Factor / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D020127:Recovery of Function; D015398:Signal Transduction / Q000502:physiology; D013116:Spinal Cord / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D001743:Urinary Bladder / Q000294:innervation / Q000502:physiology; D014549:Urinary Incontinence / Q000503:physiopathology*; D014554:Urination / Q000502:physiology*
D018992:Myelin-Associated Glycoprotein; D019006:Neural Cell Adhesion Molecules; D020932:Nerve Growth Factor