[Changes of myocardial fibrotic indices and its mechanism in patients with ischemic cardiomyopathy].
OBJECTIVE
To investigate the myocardial fibrotic indices in patients with ischemic cardiomyopathy (ICM), and explore the mechanism of myocardial fibrosis.


METHODS
The concentration of serum procollagen type III aminoterminal peptide (P III P), procollagen type IV aminoterminal peptide (P IV P), lamnin (LN), and hyaluronic acid (HA), as well as plasma angiotension II (AngII), aldosterone (ALD), and transforming growth factor beta 1 (TGFbeta1) in 46 ICM patients and 37 normal controls were measured by radioimmunoassay (RIA). The correlations between the plasma levels of AngII, ADL, TGFbeta1, and serum levels of P III P, P IV P, LN, and HA were analyzed.


RESULTS
Compared with normal controls, the concentrations of serum P III P, P IV P, LN, HA, and plasma AngII, ADL, and TGfbeta1, significantly increased in ICM patients. AngII, ALD, and TGFbeta1 levels were positively correlated with the indices of myocardial fibrosis.


CONCLUSIONS
The myocardial fibrosis exists in ICM patients and the serum concentrations of P III P, P IV P, LN, and HA may be an indirect index of myocardial fibrosis. AngII, ADL, and TGFbeta1 levels play important roles in myocardial fibrosis.
Zhang
Guo-gang
GG
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China. zyzzgg@sina.com
Zhang
Sai-dan
SD
Ouyang
Xi-ping
XP
D000368:Aged; D009202:Cardiomyopathies / Q000473:pathology*; D024061:Collagen Type III / Q000097:blood; D003324:Coronary Artery Disease / Q000473:pathology*; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*
D024061:Collagen Type III; D007797:Laminin; D006820:Hyaluronic Acid