Deep venous thrombosis in a patient with Behçet's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills.
Behçet's disease (BD) is a multisystemic disease of unknown aetiology characterized by chronic relapsing oral aphthous lesions, genital ulcers, uveitis, and vasculopathy of both arteries and veins of all sizes. We present the case of a female patient, with BD on oral contraceptive pills, who sustained deep venous thrombosis of the long saphenous vein. The patient was found to be a carrier of a homozygous mutation of the prothrombin (factor II) G20210A gene. Our case suggests that a thrombophilia work-up may be warranted in BD patients, especially young women before they are prescribed oral contraceptives.
Uthman
Imad
I
Department of Internal Medicine, Faculty of Medicine, American University of Beirut Medical Center, 113-6044, Beirut, Lebanon. iuthman@aub.edu.lb
Otrock
Zaher
Z
Taher
Ali
A
D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006720:Homozygote; D006801:Humans; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D020246:Venous Thrombosis / Q000235:genetics*
D003276:Contraceptives, Oral; D011516:Prothrombin