[Evaluation of the sibutramine effect on satiety with a visual analogue scale in obese adolescents].
Initially used to measure algic symptoms, visual analogue scales (VAS) can also be useful for the evaluation of satiety. The antiobesity agent sibutramine, unlike anorectic agents, decreases food intake mainly by stimulating satiety. To evaluate the effect of sibutramine on satiety, we used a VAS in obese adolescents participating in a double-blind, randomized trial comparing 10 mg of sibutramine to placebo. Each patient received 13 scales to be checked at hourly intervals, in a single day, from 9 am to 9 pm. A 500 kcal deficit diet was divided into 3 meals, with previously fixed times: 9:30 h, 12:30 h, 18:30 h. Using the scores obtained from each scale, a line graph was designed to represent the average satiety score throughout the day. Comparing the area under the curve for the 2 groups, we found 4.609 +/- 1.309 for the group treated with sibutramine and 4.141 +/- 1.432 for the placebo group, not reaching statistical significance (p= NS). Therefore, sibutramine does not seem do have an effect on satiety of obese adolescents, at least when satiety is evaluated by a VAS.
Corrêa
Lívia L
LL
Grupo de Obesidade e Transtornos Alimentares, Instituto de Psiquiatria, Instituto Estadual de Diabetes e Endocrinologia, Universidade Federal do Rio de Jane. liviacorrea@aol.com
Platt
Monique W
MW
Carraro
Lucia
L
Moreira
Rodrigo O
RO
Faria Júnior
Raul
R
Godoy-Matos
Amélio F
AF
Meirelles
Ricardo M R
RM
Póvoa
Luiz César
LC
Appolinário
José C
JC
Coutinho
Walmir F
WF
D000293:Adolescent; D001067:Appetite Depressants / Q000494:pharmacology / Q000627:therapeutic use*; D003503:Cyclobutanes / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D012528:Satiety Response / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D015431:Weight Loss / Q000187:drug effects; D014894:Weights and Measures
D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine