Photoinitiated free radical carbonylation enhanced by photosensitizers.
[reaction: see text] The enhancing effect of several photosensitizers in photoinitiated radical carbonylation is demonstrated and applied to accelerate the synthesis of compounds labeled with short-lived 11C. With the sensitizers, the synthesis of [carbonyl-11C]esters and acids from alkyl iodides, [11C]carbon monoxide, alcohols, and water provided up to 75-85% decay-corrected radiochemical yields in 6-min reactions under mild conditions. Acetone was used as a sensitizer in preparing 13C-substituted 1,10-decanedicarboxylic acid from (13C)carbon monoxide.
Itsenko
Oleksiy
O
Department of Organic Chemistry, Institute of Chemistry, Uppsala University, Box 599, S-751 21 Uppsala, Sweden.
Långström
Bengt
B