Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors.
The synthesis and biological activity of a novel series of 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones are described. Some of these compounds were found to be potent inhibitors of inosine 5'-monophosphate dehydrogenase type II (IMPDH II).
Birch
Helen L
HL
UCB Celltech, Granta Park, Great Abington, Cambridge, CB1 6GS, UK.
Buckley
George M
GM
Davies
Natasha
N
Dyke
Hazel J
HJ
Frost
Elizabeth J
EJ
Gilbert
Philip J
PJ
Hannah
Duncan R
DR
Haughan
Alan F
AF
Madigan
Michael J
MJ
Morgan
Trevor
T
Pitt
William R
WR
Ratcliffe
Andrew J
AJ
Ray
Nicholas C
NC
Richard
Marianna D
MD
Sharpe
Andrew
A
Taylor
Alicia J
AJ
Whitworth
Justine M
JM
Williams
Sophie C
SC
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D008968:Molecular Conformation; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D011799:Quinazolines; D007168:IMP Dehydrogenase; C501687:IMPDH2 protein, human