title: [Effect of levonorgestrel-releasing intrauterine system in the treatment of adenomyosis].
abstract: OBJECTIVE
  To assess the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis.
  
  
  METHODS
  Forty-two patients with adenomyosis diagnosed by clinical symptoms, MRI, laparoscopy and/or chromatic colour type-B ultrasound were treated with LNG-IUS, and the menstrual blood volume, severity of dysmenorrhea and uterine volume were observed three months later.
  
  
  RESULTS
  After 3 month treatment of LNG-IUS, the menstrual blood volume reduced significantly to (27 +/- 11)% of that before treatment. The uterine volume was decreased from (143 +/- 33) cm(3) to (115 +/- 22) cm(3) (P < 0.05). Dysmenorrhea was completely relieved or significantly alleviated. Hemoglobin recovered to (124 +/- 8) g/L (P < 0.05) in 20 patients with anemia.
  
  
  CONCLUSIONS
  LNG-IUS is an effective and safe method in the short-term treatment of adenomyosis.
authors.affiliation: Department of Obstetrics and Gynecology, Xiaolan People's Hospital, Zhongshan of Guangdong Province 528415, China.
authors.forename: Shu-ming
authors.initials: SM
authors.lastname: He
authors.forename: Ming-xiu
authors.initials: MX
authors.lastname: Wei
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Han
authors.forename: Li-hong
authors.initials: LH
authors.lastname: He
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000628:therapy*; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D016912:Levonorgestrel