Progenitor cell properties and the engineering of tissues.
The need for human tissue to aid in organ repair or provide a curative therapy is well known. In this review, we discuss the properties of the epidermal keratinocyte progenitor cell and the biology that underlies the methods that have helped deliver cell therapies to the clinic using this cell type. In addition, we review what the keratinocyte and the dermal fibroblast have taught us about the potential immunogenicity of allogeneic cells. The many observations made using the keratinocyte have broader biological implications and we discuss how this body of work parallels neural stem cell culture and might help us interpret cell behavior in the pancreas.
Hardin-Young
Janet
J
Amaranth Bio, Inc., Newton, MA 02464, USA.
Parenteau
Nancy L
NL
D002455:Cell Division; D006801:Humans; D007156:Immunologic Memory; D007515:Islets of Langerhans / Q000502:physiology; D015603:Keratinocytes / Q000166:cytology; D010641:Phenotype; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology; D023822:Tissue Engineering