title: [Curative effect of soybean lecithin on cerebral infarction].
abstract: OBJECTIVE
  To investigate the clinical curative effect of soybean lecithin on cerebral infarction.
  
  
  METHODS
  542 patients with cerebral infarction within 48 h after the onset with the nervous function defect scores of 31-35 were divided into 3 groups: basic treatment group, 60 cases, with conventional treatment; citicoline group, 122 patients, with conventional treatment and citicoline; and soybean lecithin group, 360 patients, with conventional treatment and soybean lecithin 10 g tid. For all patients, treatment began sometime within 48 hours after the onset. The treatment course lasted 28 days.
  
  
  RESULTS
  When the course was over, the infarct volumes in basic group citicoline group, and soybean lecithin group, were 7.6 cm3 +/- 2.9 cm3, 7.3 cm3 +/- 3.1 cm3, and 6.4 cm3 +/- 2.7 cm3 respectively (F = 7.371, P = 0.0007). The basic group and citicoline group being compared with the soybean group by Dunnett test, t = 4.387 and 3.969 respectively, P < 0.01. The nervous function defect integral in the 3 groups decreased 14.2 +/- 10.93, 15.0 +/- 9.0, and 18.5 +/- 10.9 respectively. Two-way analysis of variance of drug kind and beginning time of treatment showed the value of F in drugs as 6.250, P = 0.0021, and value of F in times as 0.9417, P = 0.4201. In the order of death,deterioration, no improvement, improvement, significant improvement, and recovery, the Ridit values for the comprehensive curative effect in the 3 groups were 0.4003, 0.4118, and 0.54 5 respectively; chi2 = 27.89, P < 0.001.
  
  
  CONCLUSIONS
  Soybean lecithin is effective in treatment of acute cerebral infarction. The mechanism may be that soybean lecithin lowers the decrease of brain phospholipid content in brain ischemia.
authors.affiliation: Department of Neurology, Genaral Hospital of Shengyang Military Command, Shengyang, China.
authors.forename: F
authors.initials: F
authors.lastname: Shi
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: D
authors.initials: D
authors.lastname: Meng
mesh_terms: D002544:Cerebral Infarction / Q000188:drug therapy*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use; D005260:Female; D006801:Humans; D054709:Lecithins / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D013025:Glycine max / Q000737:chemistry
chemical_list: D054709:Lecithins; D003566:Cytidine Diphosphate Choline