title: Intraocular histiocytosis in a 12-year-old girl without systemic disease.
abstract: Isolated intraocular histiocytosis is a rare disease that may manifest by recurrent uveitis and solid subretinal masses. The course, diagnosis and treatment of isolated intraocular histiocytosis in a 12-year-old girl are presented. As extensive diagnosis and therapy with corticosteroids and tuberculostatics failed to produce satisfactory results, diagnostic-therapeutic vitrectomy was performed. The intraoperatively obtained material was examined by the methods of histopathology, cytology and immunocytochemistry, along with herpes and cytomegalovirus polymerase chain reaction. The vitreous inflammatory exudate and subretinal masses were operatively removed. Analysis of the intraoperatively obtained material pointed to histiocytosis, whereas additional examinations revealed no systemic manifestations of the disease. Chronic uveitides that respond poorly to classic immunosuppressive therapy require multidisciplinary analysis of intraocular material. Pars plana vitrectomy is an appropriate diagnostic-therapeutic operative procedure.
authors.affiliation: University Department of Ophthalmology, Clinical Hospital Center, Rebro, Zagreb, Croatia.
authors.forename: Jakov
authors.initials: J
authors.lastname: Sikić
authors.forename: Nenad
authors.initials: N
authors.lastname: Vukojević
authors.forename: Smiljka
authors.initials: S
authors.lastname: Popović-Suić
authors.forename: Damir
authors.initials: D
authors.lastname: Katusić
mesh_terms: D002648:Child; D002908:Chronic Disease; D005260:Female; D015614:Histiocytosis / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D012163:Retinal Detachment / Q000473:pathology / Q000601:surgery; D019572:Retinal Neoplasms / Q000473:pathology / Q000601:surgery; D014605:Uveitis / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D014821:Vitrectomy