Alcohol withdrawal severity in inbred mouse (Mus musculus) strains.
Male mice (Mus musculus) from 15 standard inbred strains were exposed to a nearly constant concentration of ethanol (EtOH) vapor for 72 hr, averaging 1.59 +/- 0.03 mg EtOH/mL blood at withdrawal. EtOH- and air-exposed groups were tested hourly for handling-induced convulsions for 10 hr and at Hours 24 and 25. Strains differed markedly in the severity of withdrawal (after subtraction of control values), and by design these differences were independent of strain differences in EtOH metabolism. Correlation of strain mean withdrawal severity with other responses to EtOH supported previously reported genetic relationships of high EtOH withdrawal with low drinking, high conditioned taste aversion, low tolerance to EtOH-induced hypothermia, and high stimulated activity after low-dose EtOH. Also supported were the positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal. Sensitivity of naive mice to several chemical convulsant-induced seizures was also correlated with EtOH withdrawal.
Metten
Pamela
P
Portland Alcohol Research Center, Veterans Affairs Medical Center, Portland, OR 97239, USA. mettenp@ohsu.edu
Crabbe
John C
JC
D000430:Alcohol Withdrawal Delirium / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D020751:Alcohol-Induced Disorders / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D000704:Analysis of Variance; D000818:Animals; D002492:Central Nervous System Depressants / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D012720:Severity of Illness Index; D013045:Species Specificity; D013223:Statistics as Topic; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol