A short synthesis of lennoxamine using a radical cascade.
[reaction: see text] A short synthesis of lennoxamine has been achieved by using a radical cascade involving aryl radical-induced 7-endo cyclization and homolytic aromatic substitution.
Taniguchi
Tsuyoshi
T
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Iwasaki
Keiko
K
Uchiyama
Masahiko
M
Tamura
Osamu
O
Ishibashi
Hiroyuki
H
D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D004146:Dioxanes; D005609:Free Radicals; D006571:Heterocyclic Compounds; C442893:lennoxamine