Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand.
The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A --> G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.
Imwong
Mallika
M
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pukrittayakamee
Sasithon
S
Cheng
Qin
Q
Moore
Catrin
C
Looareesuwan
Sornchai
S
Snounou
Georges
G
White
Nicholas J
NJ
Day
Nicholas P J
NP
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use; D003062:Codon; D016054:DNA, Protozoan / Q000235:genetics / Q000302:isolation & purification; D004094:Dihydropteroate Synthase / Q000737:chemistry / Q000235:genetics*; D004338:Drug Combinations; D004351:Drug Resistance; D017125:Genes, Protozoan; D006239:Haplotypes; D016780:Malaria, Vivax / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D021141:Nucleic Acid Amplification Techniques; D010966:Plasmodium vivax / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics* / Q000302:isolation & purification; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D017434:Protein Structure, Tertiary; D011739:Pyrimethamine / Q000494:pharmacology / Q000627:therapeutic use; D013413:Sulfadoxine / Q000494:pharmacology / Q000627:therapeutic use; D013785:Thailand / Q000453:epidemiology
D000962:Antimalarials; D003062:Codon; D016054:DNA, Protozoan; D004338:Drug Combinations; D013413:Sulfadoxine; D004094:Dihydropteroate Synthase; D011739:Pyrimethamine