Lymphatic transport in rats of interesterified oils containing conjugated linoleic acids.
In this study we examined the lymphatic transport in rats of FA after administration of interesterified oils containing CLA, with emphasis on the location of CLA and octanoic acid in the TAG. The oils were produced by enzymatic interesterification. Eight oils with different structures or FA profiles were examined in this study: MCM, CMC, OCO, and COC, where M was expected to be octanoic acid and O oleic acid. In group 1, C was CLA as a mixture of the two CLA isomers c9, t11 or t10, c12, and in group 2, C was mainly the isomer t10, c12. Rats were subjected to cannulation of the mesenteric lymph duct, and the following day they were intragastrically administered one of the oils and lymph samples were collected for 24 h. The lymphatic transport of total FA from 0 to 8 h in group 1 was significantly (P < 0.05) higher for the OCO-1 and the COC-1 oils than for the CMC-1 oil. Similarly, in group 2 the transport was higher for the OCO-2 oil than for the CMC-2 oil. The recovery of both of the CLA isomers examined was similar (50-70%) and independent of the isomer, oil structure, and FA profile, whereas more octanoic acid was recovered from the CMC oils than from the MCM oils. The results indicated that the FA profiles and the position of octanoic acid had only a minor influence on the absorption of CLA.
Straarup
Ellen Marie
EM
Biochemistry and Nutrition Group, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark.
Porsgaard
Trine
T
Mu
Huiling
H
Hansen
Christina H
CH
Høy
Carl-Erik
CE
D000818:Animals; D004951:Esterification; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000737:chemistry*; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D009821:Oils / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards
D044243:Linoleic Acids, Conjugated; D009821:Oils