title: Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis.
abstract: A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1-4). The structures of compounds 1-4 were elucidated by interpretation of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
authors.forename: Noriko
authors.initials: N
authors.lastname: Sata
authors.forename: Hazel
authors.initials: H
authors.lastname: Abinsay
authors.forename: Wesley Y
authors.initials: WY
authors.lastname: Yoshida
authors.forename: F David
authors.initials: FD
authors.lastname: Horgen
authors.forename: Namthip
authors.initials: N
authors.lastname: Sitachitta
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Scheuer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006254:Hawaii; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047229:Plakortis / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones