[Spinal cord regeneration in rats after thoracic segmentectomy: restoration of the anatomical integrity of the spinal cord].
Spinal cord (SC) segmentectomy was performed at ThX level in 28 rats. The scar formation in place of surgery and the degree of restoration of anatomical integrity were studied in control rats (group I) and in rats, in which SC defect was replaced by either Spherogel neuromatrix (group II) or Spherogel containing dispersed embryonic nerve cells (group II). While in group I rats by weeks 1-2 SC defect was filled with fibrin masses, in rats of experimental groups II and III the formation of connective tissue scar was found by the same time. By weeks 10-11 these animals demonstrated partial restoration of motion in three joints of the hindlimb. In the scar tissue and in adjacent SC zones numerous regenerating thin myelinated nerve fibers were found. They were clearly demonstrated in the zones of cranial and caudal borders along the whole distance until the appearance of typical tissue of SC. In slides from the animals of control group, thin myelinated nerve fibers were found only in close proximity to SC substance, while in the scar tissue and in the cellular bands of the intermediate zone nerve fibers were scarce.
Iarygin
V N
VN
Banin
V V
VV
Iarygin
K N
KN
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage; D017690:Cell Transplantation; D002921:Cicatrix / Q000517:prevention & control; D003094:Collagen / Q000008:administration & dosage; D002818:Cordotomy; D003714:Denervation; D004195:Disease Models, Animal; D005260:Female; D007796:Laminectomy; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D013904:Thoracic Vertebrae / Q000601:surgery
D001672:Biocompatible Materials; D003094:Collagen