title: Enantioseparation of 1-phenyl-1-propanol by supercritical fluid-simulated moving bed chromatography.
abstract: The enantioseparation of 1-phenyl-1-propanol through the supercritical fluid-simulated moving bed (SF-SMB) process is studied. Non-linear isotherms were measured on an analytical column, and used together with the triangle theory for SMB design to select operating conditions for the SF-SMB. Experiments were carried out on a pilot-scale SF-SMB plant at conditions that corresponded to the non-linear range of the isotherm. Under conditions of low feed concentration, complete separation (extract purity = 99.5%; raffinate purity = 98.4%) was achieved. Under conditions of larger feed concentration, the best separation corresponded to an extract purity of 98.0% and a raffinate purity of 94.0%, and yielded a productivity of 110 g of racemate per kg stationary phase per day.
authors.affiliation: ETH Swiss Federal Institute of Technology Zurich, Institute of Process Engineering, ETH-Zentrum, ML G25, Sonneggstrasse 3, CH-8092 Zürich, Switzerland.
authors.forename: Arvind
authors.initials: A
authors.lastname: Rajendran
authors.forename: Stephanie
authors.initials: S
authors.lastname: Peper
authors.forename: Monika
authors.initials: M
authors.lastname: Johannsen
authors.forename: Marco
authors.initials: M
authors.lastname: Mazzotti
authors.forename: Massimo
authors.initials: M
authors.lastname: Morbidelli
authors.forename: Gerd
authors.initials: G
authors.lastname: Brunner
mesh_terms: D000327:Adsorption; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D001592:Benzyl Alcohols; C007656:alpha-ethylbenzyl alcohol