Aquaporin expression and freeze tolerance in Candida albicans.
Aquaporins are members of the major intrinsic protein superfamily of integral membrane proteins which enable the transport of water, glycerol, and other solutes across membranes in various organisms. In microorganisms, the physiological role of aquaporins is not yet defined. We found a clear correlation between expression of the Candida albicans aquaporin-encoding gene AQY1 and freeze tolerance. A connection with the function for the aquaporin in the natural environment of C. albicans is, however, not obvious.
Tanghe
An
A
Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium. An.Tanghe@bio.kuleuven.be
Carbrey
Jennifer M
JM
Agre
Peter
P
Thevelein
Johan M
JM
Van Dijck
Patrick
P
D020346:Aquaporins / Q000235:genetics / Q000378:metabolism*; D002176:Candida albicans / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D005615:Freezing; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D016133:Polymerase Chain Reaction; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
C115153:AQY1 protein, S cerevisiae; D020346:Aquaporins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins