Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition.
Membrane lipids play an important role in the function of blood platelets but the mechanisms by which the lipid composition of the platelet membrane is adjusted remain unclear. It has been shown that stress and poly-unsaturated fatty acids modified the lipid composition of blood plasma and platelet lipids, but very little is known about the effect of stress and fatty acids on membrane platelet lipid composition. The purpose of the present investigation was to study the influence of the essential fatty acids: linoleic, linolenic and arachidonic acids on the composition of the platelet membrane lipids of rats assigned to heat and restraint stress. It was shown that injections of polyunsaturated fatty acids decrease or suppress the stress-induced increase in platelet aggregation, suppress the stress-induced modification of the composition of the platelet membrane lipids and modify the fatty acid composition of the platelet membrane phospholipids.
Ermidou-Pollet
Sophie
S
Department of Biological Chemistry, Medical School, University of Athens, Greece. sermid@med.uoa.gr
Nounopoulos
H
H
Sdougas
N
N
Szilágyi
M
M
Pollet
S
S
D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D019787:Linoleic Acid / Q000008:administration & dosage / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry*; D010974:Platelet Aggregation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000378:metabolism
D005228:Fatty Acids, Essential; D008563:Membrane Lipids; D017962:alpha-Linolenic Acid; D019787:Linoleic Acid