title: Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
abstract: A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA. xzhang11@prdus.jnj.com
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.forename: Maud
authors.initials: M
authors.lastname: Urbanski
authors.forename: Mona
authors.initials: M
authors.lastname: Patel
authors.forename: Roxanne E
authors.initials: RE
authors.lastname: Zeck
authors.forename: Geoffrey G
authors.initials: GG
authors.lastname: Cox
authors.forename: Haiyan
authors.initials: H
authors.lastname: Bian
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Conway
authors.forename: Mary
authors.initials: M
authors.lastname: Pat Beavers
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rybczynski
authors.forename: Keith T
authors.initials: KT
authors.lastname: Demarest
mesh_terms: D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D000077203:Sodium-Glucose Transporter 2 Inhibitors
chemical_list: D005960:Glucosides; D000077203:Sodium-Glucose Transporter 2 Inhibitors