title: Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf. cristagalli.
abstract: The inhibition of superoxide production by human neutrophils has been used to screen New Zealand's unique biota for anti-inflammatory natural products. Bioactivity-directed isolation on an extract of the sponge Dysidea cf. cristagalli led to a new sesquiterpene-quinone (4) with anti-inflammatory activity, plus acetylated hydroquinone (3). These compounds inhibited superoxide production in vitro with IC50's of 3 microM (3) and 11 microM (4).
authors.affiliation: TerraMarine Pharmaceuticals, New Zealand Institute for Crop & Food Research Ltd, Chemistry Department, University of Otago, PO Box 56, Dunedin, New Zealand.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: McNamara
authors.forename: Lesley
authors.initials: L
authors.lastname: Larsen
authors.forename: Nigel B
authors.initials: NB
authors.lastname: Perry
authors.forename: Jacquie L
authors.initials: JL
authors.lastname: Harper
authors.forename: Michael V
authors.initials: MV
authors.lastname: Berridge
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Chia
authors.forename: Michelle
authors.initials: M
authors.lastname: Kelly
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Webb
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047088:Dysidea / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D009520:New Zealand; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
chemical_list: C505325:20-O-acetyl-21-hydroxy-ent-isozonarol; C505324:21-hydroxy-ent-isozonarone; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011809:Quinones; D012717:Sesquiterpenes; D013481:Superoxides