Readily tunable and bifunctional L-prolinamide derivatives: design and application in the direct enantioselective Aldol reactions.
[reaction: see text] Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions.
Chen
Jia-Rong
JR
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
Lu
Hai-Hua
HH
Li
Xin-Yong
XY
Cheng
Lin
L
Wan
Jian
J
Xiao
Wen-Jing
WJ
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry; D015195:Drug Design; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D003512:Cyclohexanones; C036468:cyclohexanone; C116609:3-hydroxybutanal; D011392:Proline; C056291:prolinamide