title: Application of multidimensional scaling to preformulation sciences: a discriminatory tool to group microcrystalline celluloses.
abstract: Pre-formulation studies constitute the first step of any pharmaceutical product development and manufacture. Establishment of a comprehensive library of critical physical, chemical, biological and mechanical properties of all materials used for a formulation can be costly, tedious and time consuming, despite its importance in quality manufacturing management. This study seeks to demonstrate the pharmaceutical application of multidimensional scaling (MDS) by incorporating it as a pre-formulation tool for grouping an expanded range of microcrystalline celluloses (MCC). MDS presents the various MCC grades in two-dimensional space based on their torque rheological properties; thus conferring an extra dimension to the pre-formulation tool to facilitate the visualization of the relative positions of each MCC grade. Through this work, the utility of MDS for expediting pre-formulation studies, in particular, grouping of excipients that are available in different brands and grades can be amply exemplified.
authors.affiliation: Department of Pharmacy, National University of Singapore.
authors.forename: Celine Valeria
authors.initials: CV
authors.lastname: Liew
authors.forename: Josephine Lay Peng
authors.initials: JL
authors.lastname: Soh
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Daming
authors.initials: D
authors.lastname: Shi
authors.forename: Paul Wan Sia
authors.initials: PW
authors.lastname: Heng
mesh_terms: D002482:Cellulose / Q000737:chemistry* / Q000145:classification*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D016571:Neural Networks, Computer; D010316:Particle Size; D011786:Quality Control; D012212:Rheology
chemical_list: D002482:Cellulose; C109691:microcrystalline cellulose