title: Malignant hypercalcemia in vulvar cancer.
abstract: Humoral hypercalcemia of malignancy (HHM) is a common paraneoplastic syndrome, most often associated with squamous cell carcinoma of the lung, esophagus, kidneys and breast, but rarely with vulval cancer. In most patients, HHM is associated with over-production of a peptide analogue of parathormone (parathyroid hormone-related protein, PTHrP). The case of a 70-year-old patient with massive squamous cell epithelioma of the vulva complicated by HHM is reported. To our knowledge, this is the first documented case with high serum concentrations of PTHrP and immunohistochemical confirmation of PTHrP production by neoplastic cells.
authors.affiliation: Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy. bilenchi@unisi.it
authors.forename: R
authors.initials: R
authors.lastname: Bilenchi
authors.forename: S
authors.initials: S
authors.lastname: Poggiali
authors.forename: C
authors.initials: C
authors.lastname: Pisani
authors.forename: R
authors.initials: R
authors.lastname: Santopietro
authors.forename: C
authors.initials: C
authors.lastname: Miracco
authors.forename: R
authors.initials: R
authors.lastname: Vatti
authors.forename: B
authors.initials: B
authors.lastname: Lucani
authors.forename: A
authors.initials: A
authors.lastname: Andreassi
authors.forename: S
authors.initials: S
authors.lastname: Gonnelli
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000378:metabolism; D044162:Parathyroid Hormone-Related Protein / Q000096:biosynthesis; D014846:Vulvar Neoplasms / Q000150:complications* / Q000378:metabolism
chemical_list: D044162:Parathyroid Hormone-Related Protein