Duplication of the hypophysis associated with precocious puberty: presentation of two cases and review of pituitary embryogenesis.
Pituitary duplication is a rare malformation commonly associated with other major neural/craniofacial anomalies, easily shown by magnetic resonance imaging. The authors describe two girls with duplication of the pituitary gland and thickening of the hypothalamus, facial dysmorphism and precocious pubertal development. The pathogenesis of pituitary duplication and its relationship with precocious pubertal development are discussed.
de Penna
Gustavo Cancela
GC
Serviço de Endocrinologia, Hospital Felício Rocho, Belo Horizonte, MG.
Pimenta
Márcia Porto
MP
Drummond
Juliana B
JB
Sarquis
Marta
M
Martins
José Carlos T
JC
de Campos
Rodrigo C
RC
Dias
Eduardo Pimentel
EP
D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000002:abnormalities* / Q000196:embryology; D011629:Puberty, Precocious / Q000209:etiology*