Synthesis and biological evaluation of novel steroid-modified ether phospholipids.
Platelet activating factor is one of the most potent inflammatory ether phospholipid mediators known and structurally modified analogues are of considerable interest as potential therapeutic preparations. Inspired by the proposed structure for a novel endogenous hydroxy-PAF analogue isolated recently from gingival crevicular fluid, we designed and prepared two novel steroid-modified ether phospholipids. These two novel compounds exhibit marked chemical and biological similarities to their endogenous prototype and they antagonize it being less active in inducing washed platelet aggregation through PAF receptors.
Karantonis
Haralabos C
HC
Laboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis, GR-157 71 Athens, Greece.
Pitsinos
Emmanuel N
EN
Antonopoulou
Smaragdi
S
Couladouros
Elias A
EA
Demopoulos
Constantinos A
CA
D000107:Acetylation; D000818:Animals; D002776:Cholestanes / Q000737:chemistry*; D066298:In Vitro Techniques; D010742:Phospholipid Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000737:chemistry* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits
D002776:Cholestanes; D010742:Phospholipid Ethers; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors