title: [Lymphocytic infiltration after oral administration of tamsulosin (Alna)].
abstract: A 69-year old patient developed dark red plaques located at his trunk, rima ani, both sides of his elbows and on his fingers after oral administration of tamsulosin (Alna). The skin eruptions disappeared and recurred in a reproducible fashion when tamsulosin was briefly discontinued. A skin biopsy taken from a UVA-exposed area on the back showed the histological features of a lymphocytic infiltration. Type-I and type-IV allergic reactions against tamsulosin could not be detected by prick and epicutaneous tests. To our knowledge this is the first report describing a lymphocytic infiltrated caused by tamsulosin. The skin eruptions disappeared and have not recurred since the medication was discontinued.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Venerologie der Universität Köln, Deutschland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Diesler
authors.forename: Frank
authors.initials: F
authors.lastname: Hirche
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hunzelmann
mesh_terms: D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D006801:Humans; D008218:Lymphocytosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012651:Self Medication; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*; D000077409:Tamsulosin
chemical_list: D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin