Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) -- structural investigations on two different carrier systems.
Two different types of colloidal lipid particles are presented and compared as innovative carrier systems. Size distribution and storage stability of formulations produced by hot high pressure homogenisation in lab and medium scale production were investigated by laser diffractometry (LD) and photon correlation spectroscopy (PCS). Nanoparticles were characterised by their melting and recrystallisation behaviour recorded by differential scanning calorimetry (DSC). Electron microscope investigations were also carried out showing the particulate character of these carriers. Reasons for observed differences in loading capacity are discussed and possibilities for dermal application are described.
Saupe
Anne
A
Department of Pharmaceutical Technology, Biotechnology & Quality Management, Kelchstr. 31, 12169 Berlin, Germany.
Wissing
Sylvia A
SA
Lenk
Andreas
A
Schmidt
Corinna
C
Müller
Rainer H
RH
D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D004337:Drug Carriers / Q000032:analysis / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000032:analysis / Q000737:chemistry*; D008422:Materials Testing; D043942:Nanotubes / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013499:Surface Properties
D001672:Biocompatible Materials; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes