title: Combining Pharmacotherapy with cognitive-behavioral interventions for obsessive-compulsive disorder.
abstract: This paper reviews the evidence-based literature concerning the efficacy and effectiveness of cognitive behavior therapy (CBT), drug treatment and their combination for obsessive compulsive disorder (OCD). After a brief outline of the seminal studies, the state of the art is presented with reference to the consensual recommendations proposed in the last 10 years. Management of OCD rests on potent selective serotonin reuptake inhibitors and CBT, used separately, sequentially, or concurrently. A hierarchical model for clinical decision-making is reported. With greater severity of OCD, it is recommended to add medications. However, the response rate is still too low in many patients, and some patients remain refractory to any kind of treatment. This stresses the importance of joint efforts of psychological and biological teams to develop new treatments.
authors.affiliation: Anxiety Disorder Unit, Hôpital Neurologique, Lyon, France. Cottraux@univ-lyon1.fr
authors.forename: Jean
authors.initials: J
authors.lastname: Cottraux
authors.forename: Martine A
authors.initials: MA
authors.lastname: Bouvard
authors.forename: Maud
authors.initials: M
authors.lastname: Milliery
mesh_terms: D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*; D017410:Practice Guidelines as Topic; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors