title: Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models.
abstract: We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.
authors.affiliation: University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA.
authors.forename: Daqing
authors.initials: D
authors.lastname: Piao
authors.forename: Mehran M
authors.initials: MM
authors.lastname: Sadeghi
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Zhang
authors.forename: Yueli
authors.initials: Y
authors.lastname: Chen
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Sinusas
authors.forename: Quing
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D002138:Calibration; D002408:Catheters, Indwelling; D004195:Disease Models, Animal; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019788:Fluorodeoxyglucose F18; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods; D011817:Rabbits; D011877:Radionuclide Imaging / Q000295:instrumentation* / Q000379:methods; D019275:Radiopharmaceuticals; D013382:Subtraction Technique / Q000295:instrumentation; D018511:Systems Integration; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods / Q000592:standards; D014159:Transducers
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18