Microbiological characteristics of medically important Trichosporon species.
Trichosporon species are opportunistic pathogens associated with a high mortality rate in immunocompromised patients. Disseminated trichosporonosis is uncommon but reports are increasing. In this study, using 16 stock clinical isolates of suspected Trichosporon species and 4 known Trichosporon strains, we investigated the morphology, physio-biochemistry, molecular biology and antifungal susceptibility characteristics of these Trichosporon spp. and discovered that ITS sequence-based identification is a rapid and accurate identification alternative to most phenotypic or physio- biochemical methods. In vitro antifungal susceptibility tests showed high amphotericin B, itraconazole and terbinafine MIC value in these Trichosporon strains.
Li
Hou-Min
HM
Department of Dermatology/Research Center of Medical Mycology, Peking University First Hospital, Beijing, PR China.
Du
Hong-Tao
HT
Liu
Wei
W
Wan
Zhe
Z
Li
Ruo-Yu
RY
D000935:Antifungal Agents / Q000494:pharmacology; D001483:Base Sequence; D004271:DNA, Fungal / Q000032:analysis; D021903:DNA, Ribosomal Spacer / Q000032:analysis*; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016533:Mycological Typing Techniques; D009181:Mycoses / Q000382:microbiology*; D010641:Phenotype; D013045:Species Specificity; D014250:Trichosporon / Q000145:classification* / Q000187:drug effects / Q000235:genetics* / Q000648:ultrastructure
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer