title: Magnesium deficiency is associated with periodontal disease.
abstract: In the multifactorial pathogenesis of periodontitis, there are still unknown factors influencing the outcome of the disease. An association between magnesium and periodontitis has been suggested by preliminary studies. However, relevant clinical data are lacking. We investigated the association between magnesium status and periodontal health in a population-based analysis. We conducted a cross-sectional epidemiological investigation involving 4290 subjects aged 20-80 yrs. We recorded periodontal risk factors and determined concentrations of serum magnesium and calcium, relating them to periodontal parameters. In a matched-pair study, 60 subjects using oral magnesium-containing drugs and 120 without were compared. In subjects aged 40 yrs and older, increased serum Mg/Ca was significantly associated with reduced probing depth (p<0.001), less attachment loss (p=0.006), and a higher number of remaining teeth (p=0.005). Subjects taking Mg drugs showed less attachment loss (p<0.01) and more remaining teeth than did their matched counterparts. These results suggest that nutritional magnesium supplementation may improve periodontal health.
authors.affiliation: Department of Pharmacology, Ernst Moritz Arndt University, F.-Loeffler-Str. 23d, D-17487 Greifswald, Germany. meiselp@unigreifswald.de
authors.forename: P
authors.initials: P
authors.lastname: Meisel
authors.forename: C
authors.initials: C
authors.lastname: Schwahn
authors.forename: J
authors.initials: J
authors.lastname: Luedemann
authors.forename: U
authors.initials: U
authors.lastname: John
authors.forename: H K
authors.initials: HK
authors.lastname: Kroemer
authors.forename: T
authors.initials: T
authors.lastname: Kocher
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002118:Calcium / Q000097:blood*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004245:DMF Index; D003753:Dental Health Surveys; D019587:Dietary Supplements; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008274:Magnesium / Q000097:blood* / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology; D010518:Periodontitis / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology*; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D008274:Magnesium; D002118:Calcium