[5-Fluorouracil-induced small bowel toxicity in a patient with colorectal cancer].
5-Fluorouracil-induced gastro-intestinal toxicity predominantly affects the upper and the lower gastro-intestinal tract. Although 5-fluorouracil (5-FU) can cause severe small-bowel toxicity, this has been reported only in 6 patients with colon carcinoma receiving 5-FU-based therapy. The presentation was extensive ulceration and inflammation of the small bowel with no involvement of the colon. We report another case of this toxicity, and discuss the diagnosis and mechanisms by which 5-FU can induce small-bowel toxicity.
Llorca Ferrándiz
Cristina
C
Unidad de Oncología, Hospital General Elda, Crta. Elda a Sax s/n, 03600 Elda, Alicante, Spain. cllorcaf@seom.org
Esquerdo Galiana
Gaspar
G
Cervera Grau
José Manuel
JM
Briceño García
Hugo Claudio
HC
Calduch Broseta
Juan Vicente
JV
Del Pino Cuadrado
José
J
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007079:Ileitis / Q000139:chemically induced*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil