title: Visual recovery after perinatal stroke evidenced by functional and diffusion MRI: case report.
abstract: BACKGROUND
  After perinatal brain injury, clinico-anatomic correlations of functional deficits and brain plasticity remain difficult to evaluate clinically in the young infant. Thus, new non-invasive methods capable of early functional diagnosis are needed in young infants.
  
  
  METHODS
  The visual system recovery in an infant with perinatal stroke is assessed by combining diffusion tensor imaging (DTI) and event-related functional MRI (ER-fMRI). All experiments were done at 1.5T. A first DTI experiment was performed at 12 months of age. At 20 months of age, a second DTI experiment was performed and combined with an ER-fMRI experiment with visual stimuli (2 Hz visual flash). At 20 months of age, ER-fMRI showed significant negative activation in the visual cortex of the injured left hemisphere that was not previously observed in the same infant. DTI maps suggest recovery of the optic radiation in the vicinity of the lesion. Optic radiations in the injured hemisphere are more prominent in DTI at 20 months of age than in DTI at 12 months of age.
  
  
  CONCLUSIONS
  Our data indicate that functional cortical recovery is supported by structural modifications that concern major pathways of the visual system. These neuroimaging findings might contribute to elaborate a pertinent strategy in terms of diagnosis and rehabilitation.
authors.affiliation: Department of Radiology, Geneva University Hospitals, Micheli-du-Crest 24, 1211 Geneva, Switzerland. Mohamed.Seghier@medecine.unige.ch
authors.forename: Mohamed L
authors.initials: ML
authors.lastname: Seghier
authors.forename: François
authors.initials: F
authors.lastname: Lazeyras
authors.forename: Slava
authors.initials: S
authors.lastname: Zimine
authors.forename: Sonja
authors.initials: S
authors.lastname: Saudan-Frei
authors.forename: Avinoam B
authors.initials: AB
authors.lastname: Safran
authors.forename: Petra S
authors.initials: PS
authors.lastname: Huppi
mesh_terms: D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000503:physiopathology; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D014785:Vision, Ocular / Q000502:physiology*; D014795:Visual Pathways / Q000098:blood supply / Q000503:physiopathology