title: On the role of arginine-glutamic acid ion pair in the ATP hydrolysis.
abstract: The complex between adenosine triphosphate (ATP) and 4-guanidinobutyric acid (GBA) has been studied by infrared spectroscopy dry and hydrated (60% relative humidity). Partial nonenzymic hydrolysis has been detected, as deduced from characteristic bands of adenosine diphosphate (ADP) and inorganic orthophosphate formation. An infrared continuum, which increases upon hydration, demonstrates that the hydrogen bonded system in this complex has a large proton polarizability due to collective proton fluctuation. On this basis, a mechanism for splitting of lytic water molecules is also discussed.
authors.affiliation: Instituto de Estructura de la Materia (CSIC), Serrano 121, 28006 Madrid, Spain. p.carmona@iem.cfmac.csic.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Carmona
authors.forename: Marina
authors.initials: M
authors.lastname: Molina
authors.forename: Arantxa
authors.initials: A
authors.lastname: Rodríguez-Casado
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D001120:Arginine / Q000737:chemistry*; D002087:Butyrates / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry*; D006860:Hydrogen Bonding; D006868:Hydrolysis; D007477:Ions / Q000737:chemistry*; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry; D011522:Protons; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry
chemical_list: D002087:Butyrates; D006146:Guanidines; D007477:Ions; D010710:Phosphates; D011522:Protons; D014867:Water; C001317:gamma-guanidinobutyric acid; D018698:Glutamic Acid; D000255:Adenosine Triphosphate; D001120:Arginine