[Expression of receptor activator of NF-kappa B ligand and osteoprotegerin protein in the giant cell lesions of jaw].
OBJECTIVE
To detect the expression of RANKL and OPG protein in the giant cell lesions of jaw and to study the mechanism of this lesion.


METHODS
RANKL and OPG were detected by immunohistochemistry (SP) in 24 paraffin-embedded and 2 frozen specimens of central giant cell lesion of jaw.


RESULTS
RANKL signals were strongly positive in the vascular epithelial cells. They also could be found in fibrous stroma, bone matrix, and stromal spindle cells, even in some cytomembrane of multinucleated giant cells. OPG was detected in multinucleated giant cells and a fraction of round mononuclear cells.


CONCLUSIONS
Active vascular epithelial cells are contributed to the formation of multinucleated giant cells through regulating RANKL, and RANKL could play its role by paracrine and autocrine, which might be inhibited by OPG.
Meng
Xue-mei
XM
Department of Periodontology, School of Stomatology, Tianjin Medical University, Tianjin 300070, China.
Yu
Shi-feng
SF
Wei
Ming-jie
MJ
D015726:Giant Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007571:Jaw Diseases / Q000378:metabolism / Q000473:pathology*; D010010:Osteoclasts / Q000378:metabolism; D053244:Osteoprotegerin / Q000378:metabolism*; D053245:RANK Ligand / Q000378:metabolism*
D053244:Osteoprotegerin; D053245:RANK Ligand; C505688:TNFSF11 protein, human