title: Metathesis reactions of pyrazolotriazinones generate dynamic combinatorial libraries.
abstract: [reaction: see text] Reversible metathesis reactions of pyrazolotriazinones and aliphatic aldehydes or ketones proceed in aqueous, phosphate-buffered media at pH 4 and 40-60 degrees C to generate thermodynamically controlled mixtures of heterocycles.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: S Graciela
authors.initials: SG
authors.lastname: Mahler
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumura
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D016208:Databases, Factual; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D001391:Azo Compounds; D011720:Pyrazoles; C031280:pyrazole