In vitro activity of fluoroquinolones against Mycoplasma genitalium and their bacteriological efficacy for treatment of M. genitalium-positive nongonococcal urethritis in men.
We investigated the minimum inhibitory concentrations of some fluoroquinolones for Mycoplasma genitalium and their bacteriological efficacy in the treatment of M. genitalium-positive nongonococcal urethritis. In vitro, levofloxacin was less active than gatifloxacin, tosufloxacin, and sparfloxacin. In vivo, the bacteriological efficacy of gatifloxacin was superior to that of levofloxacin or tosufloxacin.
Yasuda
M
M
Division of Disease Control, Research Field of Medical Sciences, Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan.
Maeda
S
S
Deguchi
T
T
D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009175:Mycoplasma Infections / Q000188:drug therapy*; D045704:Mycoplasma genitalium / Q000187:drug effects*; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology*
D024841:Fluoroquinolones