Interference with AI-2-mediated bacterial cell-cell communication.
Bacteria communicate by means of chemical signal molecules called autoinducers. This process, called quorum sensing, allows bacteria to count the members in the community and to alter gene expression synchronously across the population. Quorum-sensing-controlled processes are often crucial for successful bacterial--host relationships--both symbiotic and pathogenic. Most quorum-sensing autoinducers promote intraspecies communication, but one autoinducer, called AI-2, is produced and detected by a wide variety of bacteria and is proposed to allow interspecies communication. Here we show that some species of bacteria can manipulate AI-2 signalling and interfere with other species' ability to assess and respond correctly to changes in cell population density. AI-2 signalling, and the interference with it, could have important ramifications for eukaryotes in the maintenance of normal microflora and in protection from pathogenic bacteria.
Xavier
Karina B
KB
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, New Jersey 08544-1014, USA.
Bassler
Bonnie L
BL
D001419:Bacteria / Q000166:cytology* / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D001685:Biological Factors / Q000037:antagonists & inhibitors / Q000378:metabolism; D018920:Coculture Techniques; D004926:Escherichia coli / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D006714:Homoserine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000378:metabolism; D007783:Lactones / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014733:Vibrio / Q000166:cytology / Q000201:enzymology / Q000378:metabolism / Q000472:pathogenicity
D001685:Biological Factors; D029968:Escherichia coli Proteins; D007783:Lactones; C504601:LsrR protein, E coli; C091088:N-octanoylhomoserine lactone; D012097:Repressor Proteins; D006714:Homoserine; D010447:Peptide Hydrolases