title: Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Manger
authors.forename: Michael
authors.initials: M
authors.lastname: Scheck
authors.forename: Heino
authors.initials: H
authors.lastname: Prinz
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: von Kries
authors.forename: Thomas
authors.initials: T
authors.lastname: Langer
authors.forename: Krishna
authors.initials: K
authors.lastname: Saxena
authors.forename: Harald
authors.initials: H
authors.lastname: Schwalbe
authors.forename: Alois
authors.initials: A
authors.lastname: Fürstner
authors.forename: Jörg
authors.initials: J
authors.lastname: Rademann
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology*; D019151:Peptide Library; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011758:Pyrroles / Q000494:pharmacology; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D047630:Depsipeptides; D004791:Enzyme Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; C414465:MptpA protein, Mycobacterium tuberculosis; D019151:Peptide Library; D011758:Pyrroles; D011993:Recombinant Fusion Proteins; C408872:roseophilin; D017027:Protein Tyrosine Phosphatases