title: Identification of an HptB-mediated multi-step phosphorelay in Pseudomonas aeruginosa PAO1.
abstract: We herein demonstrate that the hybrid sensor PA1611 carries out specific signal transduction, through HptB (PA3345), to the response regulator PA3346 in Pseudomonas aeruginosa PAO1. As assessed by phenotypic changes in the hptB deletion mutant, the pathway is likely to be involved in the regulation of flagellar activity, the chemotaxis response, twitching motility, and biofilm formation in the bacteria.
authors.affiliation: Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsin Chu 30050, Taiwan, Republic of China.
authors.forename: Ching-Ting
authors.initials: CT
authors.lastname: Lin
authors.forename: Ying-Jung
authors.initials: YJ
authors.lastname: Huang
authors.forename: Pei-Hsuan
authors.initials: PH
authors.lastname: Chu
authors.forename: Jye-Lin
authors.initials: JL
authors.lastname: Hsu
authors.forename: Chih-Hsiang
authors.initials: CH
authors.lastname: Huang
authors.forename: Hwei-Ling
authors.initials: HL
authors.lastname: Peng
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development; D002633:Chemotaxis / Q000502:physiology; D005407:Flagella / Q000502:physiology*; D017353:Gene Deletion; D023061:Gene Order; D009068:Movement; D005810:Multigene Family; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
chemical_list: D001426:Bacterial Proteins