title: Molecular tests can allow confirmation of invasive meningococcal disease when isolates yield atypical maltose, glucose or gamma-glutamyl peptidase test results.
abstract: Analysis of atypical meningococci from invasive disease that either (i) did not produce acid from maltose and glucose or (ii) were gamma-glutamyl peptidase test negative for porA and porB DNA variable region (VR) type, multilocus sequence type, and for presence of capsule transport gene ctrA, conclusively demonstrated that these are Neisseria meningitidis.
authors.affiliation: Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Angelo
authors.initials: A
authors.lastname: Zaia
authors.forename: Julia M
authors.initials: JM
authors.lastname: Griffith
authors.forename: Tiffany R
authors.initials: TR
authors.lastname: Hogan
authors.forename: John W
authors.initials: JW
authors.lastname: Tapsall
authors.forename: Peter
authors.initials: P
authors.lastname: Bainbridge
authors.forename: Rachel
authors.initials: R
authors.lastname: Neill
authors.forename: David
authors.initials: D
authors.lastname: Tribe
mesh_terms: D004269:DNA, Bacterial / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007135:Immunoglobulin Variable Region; D008320:Maltose / Q000378:metabolism*; D008585:Meningitis, Meningococcal / Q000175:diagnosis* / Q000382:microbiology; D009345:Neisseria meningitidis / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D016133:Polymerase Chain Reaction / Q000379:methods*; D018272:Porins / Q000145:classification / Q000235:genetics; D012703:Serotyping; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D007135:Immunoglobulin Variable Region; D018272:Porins; C057699:porin protein, Neisseria; D008320:Maltose; D005723:gamma-Glutamyltransferase; D005947:Glucose