Aneuploidy involving chromosome 1 in failed-fertilized human oocytes is unrelated to maternal age.
OBJECTIVE
To study whether maternal meiotic errors in failed-fertilized oocytes involving chromosome 1 occur at frequencies similar to those involving other autosomes, and whether their frequency is affected by maternal age.


METHODS
Using fluorescence in situ hybridization (FISH), frequencies of aneusomy and chromatid pre-division involving chromosomes 1, 16, 18, and 21 were determined for 273 failed-fertilized oocytes.


RESULTS
The aneuploidy rate for chromosome 1 was 15.8%, and was neither age-dependent nor significantly different from that for chromosomes 16, 18 or 21. Only chromosome 16 exhibited an age-dependent increase in aneusomy rates. The frequency of chromatid pre-division was lower for chromosome 1 than for chromosome 18 (11.9% vs. 25.4%; p = 0.01), but not different from that for chromosomes 16 or 21.


CONCLUSIONS
Aneuploidy involving chromosome 1 in failed-fertilized oocytes is unrelated to maternal age and occurs at a frequency similar to that for chromosomes 16, 18, and 21.
Weier
Jingly Fung
JF
Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Francisco, USA. jlfung@itsa.ucsf.edu
Weier
Heinz-Ulrich G
HU
Nureddin
Aida
A
Pedersen
Roger A
RA
Racowsky
Catherine
C
D000782:Aneuploidy; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002887:Chromosomes, Human, Pair 18; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008423:Maternal Age; D008540:Meiosis; D008677:Metaphase; D009865:Oocytes; D011247:Pregnancy