title: hDAF porcine cardiac xenograft maintains cardiac output after orthotopic transplantation into baboon--a perioperative study.
abstract: BACKGROUND
  Only limited data are available on the physiological functional compatibility of cardiac xenografts after orthotopic pig to baboon transplantation (oXHTx). Thus we investigated hemodynamic parameters including cardiac output (CO) before and after oXHTx.
  
  
  METHODS
  Orthotopic xenogeneic heart transplantation from nine hDAF transgeneic piglets to baboons was performed. We used femoral arterial thermodilution for the invasive assessment of CO and stroke volume.
  
  
  RESULTS
  Baseline CO of the baboons after induction of anesthesia was 1.36 (1.0-1.9) l/min. 30 to 60 min after termination of the cardiopulmonary bypass, CO of the cardiac xenograft was significantly increased to 1.72 (1.3-2.1) l/min (P < 0.01). The stroke volumes of the baboon heart before transplantation and the cardiac xenograft was comparable [14.9 (11-26) vs. 11.8 (10-23) ml]. Thus the higher CO was achieved by an increase in heart rate after oXHTx [75.0 (69-110) vs. 140.0 (77-180)/min; P < 0.01]. Despite the increased CO, oxygen delivery was reduced [256 (251-354) vs. 227 (172-477) ml/min; P < 0.01] due to the inevitable hemodilution during the cardiopulmonary bypass and the blood loss caused by the surgical procedures.
  
  
  CONCLUSIONS
  Our results demonstrate that in the early phase after orthotopic transplantation of hDAF pig hearts to baboons, cardiac function of the donor heart is maintained and exceeds baseline CO. However, in the early intraoperative phase this was only possible by using inotropic substances and vasopressors due to the inevitable blood loss and dilution by the priming of the bypass circuit.
authors.affiliation: Clinic for Anaesthesiology, Ludwig-Maximilians University Munich, Munich, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bauer
authors.forename: Heiko
authors.initials: H
authors.lastname: Baschnegger
authors.forename: Jan M
authors.initials: JM
authors.lastname: Abicht
authors.forename: Ulrike
authors.initials: U
authors.lastname: Brandl
authors.forename: Paolo
authors.initials: P
authors.lastname: Brenner
authors.forename: Eckart
authors.initials: E
authors.lastname: Thein
authors.forename: Claus
authors.initials: C
authors.lastname: Hammer
authors.forename: Bruno
authors.initials: B
authors.lastname: Reichart
authors.forename: Klaus
authors.initials: K
authors.lastname: Peter
authors.forename: Michael
authors.initials: M
authors.lastname: Schmoeckel
authors.forename: Frank
authors.initials: F
authors.lastname: Christ
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D018958:CD55 Antigens / Q000235:genetics* / Q000378:metabolism*; D002302:Cardiac Output / Q000502:physiology*; D016027:Heart Transplantation; D006801:Humans; D010215:Papio; D013552:Swine; D019076:Transgenes / Q000235:genetics; D014183:Transplantation, Heterologous
chemical_list: D018958:CD55 Antigens