Deletion of the sigB gene in Bacillus cereus ATCC 14579 leads to hydrogen peroxide hyperresistance.
The sigB gene of Bacillus cereus ATCC 14579 encodes the alternative sigma factor sigma(B). Deletion of sigB in B. cereus leads to hyperresistance to hydrogen peroxide. The expression of katA, which encodes one of the catalases of B. cereus, is upregulated in the sigB deletion mutant, and this may contribute to the hydrogen peroxide-resistant phenotype.
van Schaik
Willem
W
Laboratory of Food Microbiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands.
Zwietering
Marcel H
MH
de Vos
Willem M
WM
Abee
Tjakko
T
D001409:Bacillus cereus / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D012808:Sigma Factor / Q000235:genetics*; D015854:Up-Regulation
D001426:Bacterial Proteins; D003470:Culture Media; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D006861:Hydrogen Peroxide; D002374:Catalase; C090103:KATA protein, Bacillus subtilis