title: Colorimetric detection of cyanide with a chromogenic oxazine.
abstract: [reaction: see text] We have designed a chromogenic oxazine for the colorimetric detection of cyanide. Indeed, the [1,3]oxazine ring of our compound opens to form a 4-nitrophenylazophenolate chromophore in response to cyanide. This quantitative chromogenic transformation permits the detection of micromolar concentrations of cyanide in water. Furthermore, our chromogenic oxazine is insensitive to the presence of large concentrations of fluoride, chloride, bromide, or iodide anions, which are generally the principal interferents in the colorimetric detection of cyanide.
authors.affiliation: Center for Supramolecular Science, Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida 33146-0431, USA.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Tomasulo
authors.forename: Françisco M
authors.initials: FM
authors.lastname: Raymo
mesh_terms: D002021:Buffers; D002863:Chromogenic Compounds / Q000737:chemistry*; D003124:Colorimetry; D003486:Cyanides / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D010078:Oxazines / Q000737:chemistry*
chemical_list: D002021:Buffers; D002863:Chromogenic Compounds; D003486:Cyanides; D010078:Oxazines