title: Small-cell lung cancer presenting as diabetes insipidus and Cushing's syndrome.
abstract: Small-cell lung cancer presenting with a combination of cranial diabetes insipidus and Cushing's syndrome secondary to ectopic adrenocorticotropin (ACTH) secretion is very rare and has only been described previously in one case report Our patient was a 49 year old man, in whom the initial presenting features of small-cell lung cancer were cranial diabetes insipidus secondary to pituitary metastases and severe hypokalaemia resulting from ectopic ACTH hormone secretion. This case is a remarkable example of the complex metabolic endocrine manifestations of small-cell lung cancer.
authors.affiliation: Department of Endocrinology, Beaumont Hospital, Dublin, Ireland. amaragha@yahoo.com
authors.forename: Amar
authors.initials: A
authors.lastname: Agha
authors.forename: Sinead
authors.initials: S
authors.lastname: Brennan
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Moore
authors.forename: Liam
authors.initials: L
authors.lastname: Grogan
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Thompson
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000175:diagnosis; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D003480:Cushing Syndrome / Q000175:diagnosis*; D003919:Diabetes Insipidus / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged