title: Effect of nebivolol and atenolol on brachial artery flow-mediated vasodilation in patients with coronary artery disease.
abstract: Endothelial dysfunction is considered to be the first step in atherogenesis as well as a predictor of adverse cardiovascular events in patients with coronary artery disease (CAD), while endothelial function improvement is associated with improved clinical outcome. Nebivolol is a beta1-adrenoreceptor antagonist with an independent beneficial action on endothelial function, increasing nitric oxide bioavailability. The aim of the present study was to examine the effects of nebivolol on endothelial function in the brachial artery in patients with CAD compared with another selective beta1 adrenergic receptor antagonist, atenolol. Thirty-five patients with stable CAD were randomized to receive either 5 mg nebivolol (n = 17) or 50 mg atenolol (n = 18) daily for 4 weeks. Each patient underwent measurement of endothelial function by means of flow-mediated dilatation (FMD) of the brachial artery before and after 4 weeks of treatment. All vasoactive drugs and cardiovascular risk factors were comparable in the two groups. No significant differences were observed between the two groups at baseline in FMD. In the atenolol group FMD remained unchanged at the end of the 4-week treatment, but in patients treated with nebivolol FMD showed a significant increase by the end of the treatment period (3.9 +/- 2.7% vs. 5.6 +/- 2.9%, p = 0.047) leading to a significantly higher value compared to patients treated with atenolol (5.6 +/- 2.9% vs. 3.4 +/- 3.2%, p = 0.041).Beta(1) blockade by nebivolol but not atenolol improves endothelial dysfunction in patients with CAD, an effect that might further reduce the risk for cardiovascular events in patients with CAD.
authors.affiliation: Department of Clinical Therapeutics, Alexandra University Hospital, Athens University, 12 Iridanou str, 11528, Greece. lekakis@tellas.gr
authors.forename: John P
authors.initials: JP
authors.lastname: Lekakis
authors.forename: Athanassios
authors.initials: A
authors.lastname: Protogerou
authors.forename: Christos
authors.initials: C
authors.lastname: Papamichael
authors.forename: Georgia
authors.initials: G
authors.lastname: Vamvakou
authors.forename: Ignatios
authors.initials: I
authors.lastname: Ikonomidis
authors.forename: Ignatios
authors.initials: I
authors.lastname: Iconomidis
authors.forename: Francesco
authors.initials: F
authors.lastname: Fici
authors.forename: Myron
authors.initials: M
authors.lastname: Mavrikakis
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D001262:Atenolol / Q000627:therapeutic use; D001578:Benzopyrans / Q000627:therapeutic use*; D001916:Brachial Artery / Q000187:drug effects* / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D004983:Ethanolamines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D014665:Vasodilator Agents; D000068577:Nebivolol; D001262:Atenolol