title: Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.
abstract: Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Oscar
authors.initials: O
authors.lastname: Zaragoza
authors.forename: Coralia
authors.initials: C
authors.lastname: Mihu
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Nosanchuk
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D048429:Cell Size / Q000187:drug effects*; D003453:Cryptococcosis / Q000188:drug therapy*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000235:genetics; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B