title: Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy.
abstract: BACKGROUND
  Spontaneous pregnancy is rare after radical cytoreduction and intraperitoneal chemotherapy.
  
  
  METHODS
  We present a case of a 28-year-old female with extensive, bulky malignant peritoneal epitheliod mesothelioma who underwent optimal cytoreduction with peritonectomy followed by intraoperative hyperthermic cisplatin and postoperative intraperitoneal paclitaxel and fluorouracil. Fourteen months after the conclusion of her therapy, she spontaneously conceived, resulting in an uneventful term pregnancy and spontaneous vaginal delivery.
  
  
  CONCLUSIONS
  Fertility may be preserved in select patients after radical cytoreduction and hyperthermic intraperitoneal chemotherapy.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, 6900 Georgia Ave., NW, Washington, DC, 20307, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Kyser
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bidus
authors.forename: Mildred
authors.initials: M
authors.lastname: Rodriguez
authors.forename: G Scott
authors.initials: GS
authors.lastname: Rose
authors.forename: John C
authors.initials: JC
authors.lastname: Elkas
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005298:Fertility; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D008654:Mesothelioma / Q000628:therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011247:Pregnancy
chemical_list: D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil