[Children of HIV-positive mothers: 4 cases of contamination in 14 years of follow-up at the Rouen University Hospital Center].
The prevention of mother-to-child transmission is important in the control of HIV. Despite preventive measures, the objective of a zero transmission rate from mother to child has not yet been reached even in Northern countries.


METHODS
A retrospective study covering a 14-year period (January 1988 through December 2001) examined records of 80 children born to HIV-positive mothers at Rouen University Hospital Center. Four children were contaminated. We report several particularities of these four children, contaminated despite the preventive measures taken.


CONCLUSIONS
Prevention of mother-to-child transmission involves not only administration of antiretrovirals during pregnancy, but also better follow-up of pregnancy and delivery and more effective management of risk factors such as drug addiction and poverty. Multidisciplinary follow-up is needed for these children in view of our current lack of knowledge of the long-range side effects of these antiretrovirals.
Yé
Diarra
D
Service de pédiatrie, Centre hospitalier universitaire Yalgado Ouédraogo, 01 BP 5488, Ouagadougou 01, Burkina Faso. yediarra@hotmail.com
Brossard
Véronique
V
Mercier
Anne
A
Marret
Stéphane
S
Clavier
Brigitte
B
Simon
François
F
Sawadogo
Alphonse
A
D019380:Anti-HIV Agents / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005602:France; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D012189:Retrospective Studies; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; D015215:Zidovudine