Microscopic polyangiitis after silicone breast implantation.
We describe the case of a patient who developed microscopic polyangiitis (MPA) after silicone breast implantation. A 60-year-old woman who had undergone silicone breast implantation was admitted to our hospital with complaints of general malaise and hematoproteinuria. She was diagnosed as having MPA with evidence of acute progressive renal failure, pulmonary hemorrhage, and positivity for myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA). A renal biopsy showed severe necrotizing and crescentic glomerulonephritis with arteriolitis. The patient received high-dose steroids and plasma exchange treatment, but died of progressive pulmonary hemorrhage and multiple cerebral hemorrhage. Silicone implantation is associated with scleroderma, systemic lupus erythematosus, and rheumatoid arthritis. This case report indicates the possibility of the development of MPA after silicone breast implantation.
Iyoda
Masayuki
M
Department of Nephrology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan, iyoda@med.showa-u.ac.jp
Ito
Jyun
J
Nagai
Hisako
H
Sato
Kasumi
K
Kuroki
Aki
A
Shibata
Takanori
T
Kitazawa
Kozo
K
Sugisaki
Tetsuzo
T
D058186:Acute Kidney Injury / Q000209:etiology*; D019928:Breast Implantation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D020034:Silicone Gels; D014657:Vasculitis / Q000209:etiology* / Q000473:pathology
D020034:Silicone Gels