title: Antifungal activity against plant pathogenic fungi of chaetoviridins isolated from Chaetomium globosum.
abstract: The Chaetomium globosum strain F0142, which was isolated from barnyard grass, showed potent disease control efficacy against rice blast (Magnaporthe grisea) and wheat leaf rust (Puccinia recondita). Two antifungal substances were purified from broth from this organism and identified as chaetoviridins A and B. Chaetoviridin A exhibited higher antifungal activity than chaetoviridin B against plant pathogenic fungi both in vitro and in vivo. Treatment with chaetoviridin A at 62.5 microg/mL suppressed the development of rice blast and wheat leaf rust by over 80%. The molecule also exhibited moderate control of tomato late blight, resulting in 50% control following the application of 125 microg/mL chaetoviridin A.
authors.affiliation: Biological Function Research Team, Korea Research Institute of Chemical Technology, Taejon.
authors.forename: Joong-Hyeop
authors.initials: JH
authors.lastname: Park
authors.forename: Gyung Ja
authors.initials: GJ
authors.lastname: Choi
authors.forename: Kyoung Soo
authors.initials: KS
authors.lastname: Jang
authors.forename: He Kyoung
authors.initials: HK
authors.lastname: Lim
authors.forename: Heung Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Kwang Yun
authors.initials: KY
authors.lastname: Cho
authors.forename: Jin-Cheol
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects*; D002597:Chaetomium / Q000737:chemistry*; D020082:Magnaporthe / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010935:Plant Diseases / Q000382:microbiology
chemical_list: D000935:Antifungal Agents