title: A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility.
abstract: Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk haplotype for multiple sclerosis (at HLA on chromosome 6), which explains only a fraction of the increased risk to siblings. Association scans such as admixture mapping have much more power, in principle, to find the weak factors that must explain most of the disease risk. We describe here the first high-powered admixture scan, focusing on 605 African American cases and 1,043 African American controls, and report a locus on chromosome 1 that is significantly associated with multiple sclerosis.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. reich@receptor.med.harvard.edu
authors.forename: David
authors.initials: D
authors.lastname: Reich
authors.forename: Nick
authors.initials: N
authors.lastname: Patterson
authors.forename: Philip L
authors.initials: PL
authors.lastname: De Jager
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: McDonald
authors.forename: Alicja
authors.initials: A
authors.lastname: Waliszewska
authors.forename: Arti
authors.initials: A
authors.lastname: Tandon
authors.forename: Robin R
authors.initials: RR
authors.lastname: Lincoln
authors.forename: Cari
authors.initials: C
authors.lastname: DeLoa
authors.forename: Scott A
authors.initials: SA
authors.lastname: Fruhan
authors.forename: Philippe
authors.initials: P
authors.lastname: Cabre
authors.forename: Odile
authors.initials: O
authors.lastname: Bera
authors.forename: Gilbert
authors.initials: G
authors.lastname: Semana
authors.forename: M Ann
authors.initials: MA
authors.lastname: Kelly
authors.forename: David A
authors.initials: DA
authors.lastname: Francis
authors.forename: Kristin
authors.initials: K
authors.lastname: Ardlie
authors.forename: Omar
authors.initials: O
authors.lastname: Khan
authors.forename: Bruce A C
authors.initials: BA
authors.lastname: Cree
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Hauser
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Oksenberg
authors.forename: David A
authors.initials: DA
authors.lastname: Hafler
mesh_terms: D001741:Black or African American / Q000235:genetics; D002874:Chromosome Mapping / Q000379:methods; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D009103:Multiple Sclerosis / Q000208:ethnology / Q000235:genetics*