Enzymatic production of caffeic acid by koji from plant resources containing caffeoylquinic acid derivatives.
The effect of a koji (Aspergillus awamori mut.) extract on the caffeoylquinic acid derivatives purified from sweetpotato (Ipomoea batatas L.) leaves was examined to develop the mass production of caffeic acid. A koji extract hydrolyzed the caffeoylquinic acid derivatives, chlorogenic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid and 3,4,5-tri-O-caffeoylquinic acid, to caffeic acid. Furthermore, the koji extract also converted the major polyphenolic components from sweetpotato, burdock (Arctium lappa L.), and mugwort (Artemisia indica var. maximowiczii) leaves to caffeic acid. These results suggest that the production of caffeic acid from plant resources containing caffeoylquinic acid derivatives is possible.
Yoshimoto
Makoto
M
Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region, Miyazaki 885-0091, Japan. mak825@affrc.go.jp
Kurata-Azuma
Rie
R
Fujii
Makoto
M
Hou
De-Xing
DX
Ikeda
Kohji
K
Yoshidome
Tomohisa
T
Osako
Miho
M
D001230:Aspergillus / Q000737:chemistry / Q000201:enzymology*; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis; D027723:Ipomoea batatas / Q000737:chemistry* / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry* / Q000378:metabolism; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D002109:Caffeic Acids; C472707:caffeoylquinic acid; D011801:Quinic Acid; C040048:caffeic acid