A peptide motif recognizing a polymer stereoregularity.
A combinatorial phage display method was applied to films composed of a stereoregular polymer of methacrylates. The phage clones with selective affinity for isotactic (it) poly(methyl methacrylate) (PMMA) were isolated. Greater amounts of the phage clones bound to it-PMMA, compared to other stereoregular PMMAs. The phage expressing ELWRPTR most strongly bound to the polymer, and the selectivity was also the best. The peptide motif essential for the specific interaction with the stereoregular polymer was revealed.
Serizawa
Takeshi
T
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. t-serizawa@bionano.rcast.u-tokyo.ac.jp
Sawada
Toshiki
T
Matsuno
Hisao
H
Matsubara
Teruhiko
T
Sato
Toshinori
T
D020816:Amino Acid Motifs / Q000502:physiology; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
D019151:Peptide Library; D010455:Peptides; D011108:Polymers