Biochemical and histological studies on H2-receptor antagonist ranitidine-induced hepatotoxicity in rats.
This study was designed to investigate the hepatotoxicity of ranitidine treatment in dose levels of 10, 30, and 50 mg/kg b.wt. for 3 weeks period in male rats. The results showed some adverse changes in rats treated with either 10 or 30 mg/kg. Treatment with dose of 50 mg/kg produced marked increase in the activity of both acid phosphatase in liver and aspartate aminotransferase in serum and liver, with a tendency for increase in serum alanine aminotransferase activity. Also, a significant decrease in the serum activity of both amylase and alkaline phosphatase was noted. Microscopic examination of livers of the same animals revealed absence of some hepatic cells, pyknotic nuclei, dilatation of blood sinusoids, binucleated cells, and infiltration of lymphocytes. These biochemical and histological changes indicate that ranitidine when given chronically in high dose could produce hepatotoxicity in rats.
Hemieda
Faried A E
FA
Zoology Department, Faculty of Science, Mansoura University, Egypt. faried@mans.edu.eg
Abdel-Hady
El-Sayed K
el-SK
Elnga
Mostafa A Abou
MA
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011899:Ranitidine / Q000633:toxicity*; D051381:Rats
D006635:Histamine H2 Antagonists; D011899:Ranitidine; D001219:Aspartate Aminotransferases; D000135:Acid Phosphatase