Effect of acute airway inflammation on the pulmonary antioxidant status.
Effects of acute airway inflammation induced by organic dust inhalation on pulmonary antioxidant status were investigated in healthy horses and horses affected by recurrent airway obstruction. Exposure to organic dust induced acute airway neutrophilia, which was associated with increases in elastase and decreases in ascorbic acid concentrations in bronchoalveolar lavage fluid. However, markers of oxidative stress were unaffected, as was hydrogen peroxide in breath condensate. Decreases in ascorbic acid correlated with increased respiratory resistance (P = .001) when both groups were combined. In conclusion, acute neutrophilic airway inflammation does not result in significant evidence of oxidative stress in horses affected by recurrent airway obstruction.
Deaton
Christopher M
CM
Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, UK. chris.deaton@aht.org.uk
Marlin
David J
DJ
Smith
Nicola C
NC
Harris
Patricia A
PA
Dagleish
Mark P
MP
Schroter
Robert C
RC
Kelly
Frank J
FJ
D000208:Acute Disease; D000402:Airway Obstruction / Q000150:complications / Q000503:physiopathology / Q000662:veterinary; D000403:Airway Resistance; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D004391:Dust; D005260:Female; D006734:Horse Diseases / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D006736:Horses; D019272:Leukocyte Elastase / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000473:pathology; D018384:Oxidative Stress; D011014:Pneumonia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology / Q000662:veterinary*
D000975:Antioxidants; D004391:Dust; D019272:Leukocyte Elastase