title: Enzymatic production of caffeic acid by koji from plant resources containing caffeoylquinic acid derivatives.
abstract: The effect of a koji (Aspergillus awamori mut.) extract on the caffeoylquinic acid derivatives purified from sweetpotato (Ipomoea batatas L.) leaves was examined to develop the mass production of caffeic acid. A koji extract hydrolyzed the caffeoylquinic acid derivatives, chlorogenic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid and 3,4,5-tri-O-caffeoylquinic acid, to caffeic acid. Furthermore, the koji extract also converted the major polyphenolic components from sweetpotato, burdock (Arctium lappa L.), and mugwort (Artemisia indica var. maximowiczii) leaves to caffeic acid. These results suggest that the production of caffeic acid from plant resources containing caffeoylquinic acid derivatives is possible.
authors.affiliation: Department of Upland Farming Research, National Agricultural Research Center for Kyushu Okinawa Region, Miyazaki 885-0091, Japan. mak825@affrc.go.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Rie
authors.initials: R
authors.lastname: Kurata-Azuma
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujii
authors.forename: De-Xing
authors.initials: DX
authors.lastname: Hou
authors.forename: Kohji
authors.initials: K
authors.lastname: Ikeda
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Yoshidome
authors.forename: Miho
authors.initials: M
authors.lastname: Osako
mesh_terms: D001230:Aspergillus / Q000737:chemistry / Q000201:enzymology*; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis; D027723:Ipomoea batatas / Q000737:chemistry* / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry* / Q000378:metabolism; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
chemical_list: D002109:Caffeic Acids; C472707:caffeoylquinic acid; D011801:Quinic Acid; C040048:caffeic acid