title: Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada.
abstract: OBJECTIVE
  We conducted a phase III trial to determine whether first-line treatment with raltitrexed, a thymidine synthase inhibitor, and cisplatin results in superior outcome compared with cisplatin alone in patients with malignant pleural mesothelioma (MPM).
  
  
  METHODS
  Eligible patients with histologically proven advanced MPM, not pretreated with chemotherapy, WHO performance status (PS) 0 to 2, and adequate hematological, renal, and hepatic function were randomly assigned to receive cisplatin 80 mg/m2 IV on day 1, alone (arm A) or combined with raltitrexed 3 mg/m2 (arm B). In patients with measurable disease, response was monitored using the Response Evaluation Criteria in Solid Tumors criteria. Health related quality of life (HRQOL) was measured using the European Organisation for Research and Treatment of Cancer QLQ-C30 and Lung Module (QLQ-LC13).
  
  
  RESULTS
  Two hundred fifty patients were randomized: 80% male; median age, 58 years; and WHO PS, 0, 1, 2 in 25, 62, and 13% of cases, respectively. There were no toxic deaths. The main grade 3 or 4 toxicities observed were neutropenia and emesis, reported twice as often in the combination arm. Among 213 patients with measurable disease, response rate was 13.6% (arm A) versus 23.6% (arm B; P = .056). No difference in HRQOL was observed on any of the scales. Median overall and 1-year survival in arms A and B were 8.8 (95% CI, 7.8 to 10.8) v 11.4 months (95% CI, 10.1 to 15), respectively, and 40% v 46%, respectively (P = .048).
  
  
  CONCLUSIONS
  A combination of raltitrexed and cisplatin improves overall survival compared with cisplatin alone. This study confirms that a combination of cisplatin and an antifolate is superior to cisplatin alone in patients with MPM, without harmful effect on HRQOL.
authors.affiliation: Thoracic Oncology Unit, University Hospital -7K12IE, De Pintelaan 185, B 9000 Ghent, Belgium. jan.vanmeerbeeck@ugent.be
authors.forename: Jan P
authors.initials: JP
authors.lastname: van Meerbeeck
authors.forename: Rabab
authors.initials: R
authors.lastname: Gaafar
authors.forename: Christian
authors.initials: C
authors.lastname: Manegold
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Van Klaveren
authors.forename: Eric A
authors.initials: EA
authors.lastname: Van Marck
authors.forename: Mark
authors.initials: M
authors.lastname: Vincent
authors.forename: Catherine
authors.initials: C
authors.lastname: Legrand
authors.forename: Andrew
authors.initials: A
authors.lastname: Bottomley
authors.forename: Channa
authors.initials: C
authors.lastname: Debruyne
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Giaccone
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced; D010997:Pleural Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011799:Quinazolines / Q000008:administration & dosage; D016019:Survival Analysis; D013876:Thiophenes / Q000008:administration & dosage; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced
chemical_list: D011799:Quinazolines; D013876:Thiophenes; C068874:raltitrexed; D002945:Cisplatin