title: Epidemiology of cerebrovascular disease related cognitive decline.
abstract: Cognitive decline is a central component of the dementia process. Population-based prospective studies have confirmed the existence of age-related cognitive decline, although its conceptual basis and nosological status remain controversial. Healthy old people show decline with aging in global cognition and memory function in particular. Preclinical and clinical dementia patients exhibit deficits across multiple cognitive domains, with the largest and most consistent deficits in memory function. Cerebrovascluar disease may lead to cognitive decline and promote the clinical expression of dementia directly or by interaction with APOE epsilon4. Early treatment and prevention of cerebrovascular disease may be the major measures for preventing and postponing the progression of the vascular disease related cognitive decline.
authors.affiliation: Aging Research Center, Division of Geriatric Epidemiology, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC), Karolinska Institute, Stockholm, Sweden. chengxuan.qiu@neurotec.ki.se
authors.forename: Chengxuan
authors.initials: C
authors.lastname: Qiu
authors.forename: Laura
authors.initials: L
authors.lastname: Fratiglioni
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000378:metabolism; D003072:Cognition Disorders / Q000453:epidemiology*; D006801:Humans
chemical_list: D001057:Apolipoproteins E