title: Clinical prospective study of biochemical markers and evoked potentials for identifying adverse neurological outcome after thoracic and thoracoabdominal aortic aneurysm surgery.
abstract: BACKGROUND
  Neurological deficit after repair of a thoracic or thoracoabdominal aortic aneurysm (TAA/TAAA) remains a devastating complication. The aim of our study was to investigate the clinical value of biochemical markers [S-100B, neurone-specific enolase (NSE) and lactate dehydrogenase (LD)], evoked potentials and their combinations for identifying adverse neurological outcome after TAA/TAAA surgery.
  
  
  METHODS
  From 69 patients, cerebrospinal fluid and blood samples for biochemical analysis were drawn after the induction of anaesthesia, during the cross-clamp period, 5 min, 2, 4, 6, 8, and 19 h, respectively, after reperfusion. In addition, continuous perioperative recording of motor-evoked potentials after transcranial electrical stimulation (tcMEP) and somatosensory-evoked potentials was carried out. Furthermore, neurological examinations were performed.
  
  
  RESULTS
  In patients with a defined decrease in lower extremity tcMEP during the cross-clamp period, we found that combinations of the serum concentrations of S-100B and tcMEP ratios at 4, 6, and 8 h after reperfusion had a positive and negative predictive value of 100% in predicting adverse neurological outcome after TAA/TAAA surgery. Furthermore, combinations of the serum concentrations of S-100B and NSE or LD at 19 h after reperfusion had both a positive and negative predictive value of 100% in identifying patients with adverse outcome after TAA/TAAA repair.
  
  
  CONCLUSIONS
  TcMEP monitoring during TAA/TAAA surgery seems to be an effective but not completely sufficient guide in our protective multi-modality strategy. Combinations of the serum concentrations of S-100B and tcMEP ratios during the early reperfusion period might be associated with adverse neurological complications. Furthermore, biochemical markers could detect central nervous system injury on the first postoperative day and may have prognostic value.
authors.affiliation: Department of Clinical Chemistry, St Antonius Hospital, PO Box 2500, NL-3430 EM, Nieuwegein, The Netherlands. edmeejeroen@zonnet.nl
authors.forename: E C
authors.initials: EC
authors.lastname: Lases
authors.forename: M A
authors.initials: MA
authors.lastname: Schepens
authors.forename: F J
authors.initials: FJ
authors.lastname: Haas
authors.forename: L P
authors.initials: LP
authors.lastname: Aarts
authors.forename: H T
authors.initials: HT
authors.lastname: ter Beek
authors.forename: E P
authors.initials: EP
authors.lastname: van Dongen
authors.forename: H P
authors.initials: HP
authors.lastname: Siegers
authors.forename: I
authors.initials: I
authors.lastname: van der Tweel
authors.forename: E H
authors.initials: EH
authors.lastname: Boezeman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D015415:Biomarkers / Q000378:metabolism; D019054:Evoked Potentials, Motor; D005073:Evoked Potentials, Somatosensory; D005260:Female; D018611:Heart Bypass, Left; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000378:metabolism; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000517:prevention & control; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011183:Postoperative Complications / Q000175:diagnosis* / Q000517:prevention & control; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism; D012720:Severity of Illness Index; D013048:Specimen Handling / Q000379:methods
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D007770:L-Lactate Dehydrogenase; D010751:Phosphopyruvate Hydratase