title: An update on the detoxification processes for silica particles and asbestos fibers: successess and limitations.
abstract: Inhalation of asbestos fibers and crystalline silica produces a number of diseases including fibrosis and cancer. Investigations into the mechanisms involved in mineral particle-induced toxicity indicated the importance of their surfaces in the pathological consequences. Masking of the surface sites has therefore featured prominently in a number of detoxification processes that have been investigated. The majority of the detoxification processes were, however, conducted to elucidate the involvement of a particular surface site in the toxicity of a specific mineral. Others were investigated with the aim of large industrial applications to be applied during mining, handling, processing, transporting, and disposing of minerals. It can be concluded that, to date, there is no single detoxification process that could be applied universally to all different types of mineral particles. Those that have shown some success could not completely abolish all adverse effects. Further elucidation of mechanisms of particle-induced toxicity may open new possibilities for detoxification processes.
authors.affiliation: National Institute for Occupational Health (NIOH) and Department of Hematology and Molecular Medicine, School of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Gulumm@health.gov.za
authors.forename: M
authors.initials: M
authors.lastname: Gulumian
mesh_terms: D000395:Air Pollutants, Occupational / Q000633:toxicity*; D001194:Asbestos / Q000633:toxicity*; D004391:Dust; D004784:Environmental Monitoring; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects* / Q000517:prevention & control*; D008171:Lung Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008420:Manufactured Materials; D019016:Mineral Fibers; D009784:Occupational Diseases / Q000139:chemically induced / Q000517:prevention & control*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000517:prevention & control*; D010316:Particle Size; D012822:Silicon Dioxide / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D000395:Air Pollutants, Occupational; D004391:Dust; D019016:Mineral Fibers; D001194:Asbestos; D012822:Silicon Dioxide