Transepithelial permeability of myricitrin and its degradation by simulated digestion in human intestinal Caco-2 cell monolayer.
Myricitrin permeated the human intestinal Caco-2 cell monolayer via the paracellular pathway in a time- and concentration-dependent manner. Myricitrin was not conjugated by Caco-2 cells. Myricitrin was degraded by simulated intestinal digestion, but permeability did not change significantly.
Yokomizo
Atsushi
A
Fundamental Research Division, San-Ei Gen F.F.I. Corporation, Toyonaka, Osaka 561-8588, Japan.
Moriwaki
Masamitsu
M
D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D004063:Digestion; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology*; D005419:Flavonoids / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
D005419:Flavonoids; C008577:myricitrin