Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides.
[reaction: see text] A tandem dimerization-macrocyclization approach using 1,3-dipolar azide-alkyne cycloaddition reactions has been employed in the facile and convergent solution phase syntheses of C2 symmetric cyclic peptide scaffolds bearing triazole epsilon2-amino acids as dipeptide surrogates.
van Maarseveen
Jan H
JH
Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Horne
W Seth
WS
Ghadiri
M Reza
MR
D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D012254:Ribavirin / Q000031:analogs & derivatives / Q000737:chemistry
D006571:Heterocyclic Compounds; D010456:Peptides, Cyclic; D012254:Ribavirin; C033706:tiazofurin