title: One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.
abstract: [reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.
authors.affiliation: Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259 Nagatsuta, Yokohama 226-8503, Japan.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Mohamed Ahmed
authors.forename: Kei
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Atsunori
authors.initials: A
authors.lastname: Mori
mesh_terms: D002384:Catalysis; D006830:Hydralazine / Q000737:chemistry; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D007555:Isoxazoles; D011720:Pyrazoles; D006830:Hydralazine; C031280:pyrazole; D010165:Palladium