The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population.
The polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene are associated with leukemogenesis. In order to investigate the influence of two polymorphisms in the MTHFR gene, 677C>T and 1298A>C, on the risk of acute lymphoblastic leukemia (ALL) we performed a case-control study in children from different Brazilians' regions. Genotyping of 176 ALL and 199 unselected healthy subjects was performed using PCR-RFLP assay. There was no association between the 677C>T or 1298A>C and risk of ALL in total case-control sample. However, 677T allele was linked to a decrease risk of ALL [odds ratio (OR), 0.43; 95% confidence interval (CI), 0.22-0.86], whereas the 1298A>C polymorphism presents an elevated risk factor [OR, 2.01; 95% CI, 1.01-3.99] in non-White children. Our investigation provides interesting data concerning the opposite effect of A1298C polymorphisms, particularly in the light of relatively scarce data regarding the MTHFR role in leukemia susceptibility in different populations.
Zanrosso
Crisiane Wais
CW
Divisão de Medicina Experimental, Centro de Pesquisa, Instituto Nacional de Câncer, Rua André Cavalcanti, 37, CEP 20231-050 Rio de Janeiro, Brazil.
Hatagima
Ana
A
Emerenciano
Mariana
M
Ramos
Flávio
F
Figueiredo
Alexandre
A
Félix
Têmis Maria
TM
Segal
Sandra L
SL
Giugliani
Roberto
R
Guigliani
Roberto
R
Muniz
Maria Tereza Cartaxo
MT
Pombo-de-Oliveira
Maria S
MS
D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*
D042965:Methylenetetrahydrofolate Reductase (NADPH2)