title: Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
abstract: Two novel side chains which had previously been found to enhance antagonist activity in the dihydrobenzoxathiin SERM series were applied to three existing platforms. The novel side chains did not improve the antagonist activity of the existing platforms.
authors.affiliation: Merck Research Laboratories, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Blizzard
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Morgan
authors.forename: Wanda
authors.initials: W
authors.lastname: Chan
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Birzin
authors.forename: Lee-Yuh
authors.initials: LY
authors.lastname: Pai
authors.forename: Edward C
authors.initials: EC
authors.lastname: Hayes
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: DaSilva
authors.forename: Ralph T
authors.initials: RT
authors.lastname: Mosley
authors.forename: Yi Tien
authors.initials: YT
authors.lastname: Yang
authors.forename: Susan P
authors.initials: SP
authors.lastname: Rohrer
authors.forename: Frank
authors.initials: F
authors.lastname: Dininno
authors.forename: Milton L
authors.initials: ML
authors.lastname: Hammond
mesh_terms: D000818:Animals; D047628:Estrogen Receptor alpha / Q000037:antagonists & inhibitors*; D008024:Ligands; D010075:Oxathiins / Q000737:chemistry*; D051381:Rats; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D047628:Estrogen Receptor alpha; D008024:Ligands; D010075:Oxathiins; D020845:Selective Estrogen Receptor Modulators; C500019:dihydrobenzoxathiin