Systems biology approaches in cell signaling research.
The use of methods for global and quantitative analysis of cells is providing new systems-level insights into signal transduction processes. Recent studies reveal important information about the rates of signal transmission and propagation, help establish some general regulatory characteristics of multi-tiered signaling cascades, and illuminate the combinatorial nature of signaling specificity in cell differentiation.
Chen
Raymond E
RE
Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
Thorner
Jeremy
J
D000818:Animals; D012107:Research Design; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods*