title: HTS quality control and data analysis: a process to maximize information from a high-throughput screen.
abstract: Changes in all aspects of HTS from compound management through to evaluation of hits and leads, strengthened by infrastructure improvements, in both automation and informatics, have made possible increased analysis and implementation of process and quality control throughout HTS. This paper focuses on the process of HTS with an emphasis on quality control, reducing the variability of all the processes that have an impact on the final result, and argue that by increasing the quality of the entire process that data mining of primary screening data is in fact possible and will reduce cycle times to medicinal chemistry.
authors.affiliation: Lead Discovery and Profiling, Bristol-Myers Squibb Pharmaceutical Institute, Wallingford, CT 06492, USA. Ramesh.Padmanabha@bms.com
authors.forename: Ramesh
authors.initials: R
authors.lastname: Padmanabha
authors.forename: Lynda
authors.initials: L
authors.lastname: Cook
authors.forename: James
authors.initials: J
authors.lastname: Gill
mesh_terms: D001331:Automation; D016247:Information Storage and Retrieval; D004364:Pharmaceutical Preparations; D011786:Quality Control
chemical_list: D004364:Pharmaceutical Preparations