title: [Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease].
abstract: OBJECTIVE
  To identify the genetic variants of angiotensin II type 1 receptor (AT1) gene in a population of Han ethnicity in east China and to determine whether the AT1 gene polymorphisms are associated with essential hypertension (EH) and coronary heart disease (CHD).
  
  
  METHODS
  The detection of single nucleotide polymorphisms (SNPs) was performed in 20 subjects by a direct DNA sequencing. All 213 EH patients, 171 patients of EH with CHD and 200 controls were genotyped by three detected SNPs.
  
  
  RESULTS
  Eight positive SNPs were detected in the promoter, exon and 3' untranslated region (3'UTR) of AT1 gene. A case-control study by using a frequent SNP (A-153G) in the promoter region, showed a significant increase in allele frequency of G-153 in the subjects of EH complicated with CHD (17.8% vs 11.5% for normal controls, P < 0.05). The SNP A1166C, which has been widely studied, manifested no difference in the three groups.
  
  
  CONCLUSIONS
  A polymorphism in the promoter region (A-153G) of AT1 gene might be involved in the development of EH and CHD in Han ethnicity population in east China.
authors.affiliation: Department of Cardiology, Shandong Provincial Hospital, Jinan 250021, China.
authors.forename: Kui-xing
authors.initials: KX
authors.lastname: Zhang
authors.forename: Tong-bao
authors.initials: TB
authors.lastname: Liu
authors.forename: Qiu-xia
authors.initials: QX
authors.lastname: Xu
authors.forename: Ding-liang
authors.initials: DL
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003327:Coronary Disease / Q000150:complications / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
chemical_list: D017931:DNA Primers; D044140:Receptor, Angiotensin, Type 1