title: Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: does it matter?
abstract: Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.
authors.affiliation: Neonatal Intensive Care Unit, L. Mangiagalli Hospital, IRCCS, University of Milan, Milan, Italy. lucrameng@hotmail.com
authors.forename: L A
authors.initials: LA
authors.lastname: Ramenghi
authors.forename: M
authors.initials: M
authors.lastname: Fumagalli
authors.forename: A
authors.initials: A
authors.lastname: Righini
authors.forename: F
authors.initials: F
authors.lastname: Triulzi
authors.forename: A
authors.initials: A
authors.lastname: Kustermann
authors.forename: F
authors.initials: F
authors.lastname: Mosca
mesh_terms: D000328:Adult; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000235:genetics; D002552:Cerebral Ventricles / Q000002:abnormalities*; D005165:Factor V; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D019851:Thrombophilia / Q000175:diagnosis* / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; D042965:Methylenetetrahydrofolate Reductase (NADPH2)