Modeling of drug release from bioerodible polymer matrices.
Models for drug release from bioerodible polymer matrices are proposed in this article. We consider that drug is released continually by diffusion that is influenced by polymer chain degradation, and polymer matrix erosion starts and enhances the drug release at a certain time. The models give excellent reproduction of drug release profiles within the whole release period, and the parameters can be correlated to various factors such as gamma-irradiation dose, copolymer composition, and initial drug loading, this correlation indicates that the new models can be used to predict the effects of various factors on drug release profiles based on limited experimental data.
He
Jingtao
J
Department of Chemical Engineering, Beijing University of Chemical Technology, Beijing, China.
Zhong
Chongli
C
Mi
Jianguo
J
D002208:Caproates / Q000008:administration & dosage; D016503:Drug Delivery Systems; D019344:Lactic Acid / Q000008:administration & dosage; D007783:Lactones / Q000008:administration & dosage; D008863:Microspheres; D008962:Models, Theoretical; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage*; D011374:Progesterone / Q000008:administration & dosage
D002208:Caproates; D007783:Lactones; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D011374:Progesterone; C121056:caprolactone