title: [Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia].
abstract: Electron microscopy and electrophysiological data reveal pronounced structural and functional disturbances in cerebral cortex of rats with model brain ischemia. A 5-day treatment with a dry extract from Rhaponticum carthamoides (Willd.) Iljin. in a daily dose of 150 mg/kg (p.o.) equivalent to 2.7 mg ecdysterone per kg body weight reduced manifestations of the ischemic damage, improved the structure of neurons, and restored brain activity (EEG parameters).
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
authors.forename: S V
authors.initials: SV
authors.lastname: Logvinov
authors.forename: N V
authors.initials: NV
authors.lastname: Pugachenko
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Maslov
authors.forename: O I
authors.initials: OI
authors.lastname: Aliev
authors.forename: A S
authors.initials: AS
authors.lastname: Vasil'ev
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: A V
authors.initials: AV
authors.lastname: Potapov
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000503:physiopathology* / Q000648:ultrastructure; D005260:Female; D043843:Leuzea / Q000737:chemistry; D008297:Male; D009474:Neurons / Q000648:ultrastructure; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects*
chemical_list: D010936:Plant Extracts