Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study.
The purpose of the present study was to investigate the changes in the cognitive dysfunctions of patients with obsessive-compulsive disorder (OCD) over a 1-year period of pharmacological treatment. Twenty-one OCD patients and 20 normal subjects underwent neuropsychological tests and clinical evaluations on three separate occasions (baseline, 4 months, and 1 year after the start of medications). OCD patients continued to show significant impairments in the following cognitive measures compared with the normal controls: accuracy of immediate and delayed recall on the Rey-Osterrieth complex figure tests, the numbers of responses on the category fluency test, the response time on the trail making test--part A, and the number of perseverative response and perseverative errors on the Wisconsin card sorting test. The findings in this study suggested that impaired performance on cognitive domains, such as visuospatial memory and verbal fluency may underline the pathology of OCD.
Roh
Kyu Sik
KS
Neuroscience Institute, SNU-MRC, and Department of Psychiatry, Seoul National University, Seoul, Korea.
Shin
Min Sup
MS
Kim
Myung-Sun
MS
Ha
Tae-Hyun
TH
Shin
Yong-Wook
YW
Lee
Kyung Jin
KJ
Kwon
Jun Soo
JS
D000328:Adult; D001245:Association Learning; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
D017367:Selective Serotonin Reuptake Inhibitors