title: High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir.
abstract: We evaluated the virological outcome of tenofovir plus didanosine-based regimens in 67 HIV-suppressed patients. After a median follow-up of 26 months (IQR 10.5-40.5), 12 (18%) discontinued the therapy because of virological failure. At virological failure 'de novo' selected mutations were identified in 11 of the 12 failing patients, including the K65R mutation in seven patients. These results argue against the use of tenofovir-didanosine not only in naive patients, but also in previously suppressed patients.
authors.affiliation: Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Spain.
authors.forename: Agathe
authors.initials: A
authors.lastname: León
authors.forename: Josep
authors.initials: J
authors.lastname: Mallolas
authors.forename: Esteban
authors.initials: E
authors.lastname: Martinez
authors.forename: Elisa
authors.initials: E
authors.lastname: De Lazzari
authors.forename: Tomás
authors.initials: T
authors.lastname: Pumarola
authors.forename: María
authors.initials: M
authors.lastname: Larrousse
authors.forename: Ana
authors.initials: A
authors.lastname: Milincovic
authors.forename: Montserrat
authors.initials: M
authors.lastname: Lonca
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Blanco
authors.forename: Montserrat
authors.initials: M
authors.lastname: Laguno
authors.forename: Alejandra
authors.initials: A
authors.lastname: Biglia
authors.forename: Josep María
authors.initials: JM
authors.lastname: Gatell
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D016049:Didanosine / Q000627:therapeutic use*; D024921:Drug Resistance, Multiple, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009154:Mutation; D063065:Organophosphonates / Q000627:therapeutic use*; D000068698:Tenofovir; D017211:Treatment Failure
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine; D016049:Didanosine