title: Homocysteine-lowering therapy and carotid intima-media thickness in renal transplant recipients.
abstract: The aim of this study was to document, in hyperhomocysteinemic renal transplant recipients, the effect of vitamin supplementation on carotid intima-media thickness (cIMT). Fifty-six hyperhomocysteinemic stable renal transplant recipients were randomly assigned to either vitamin supplementation (group A) or placebo treatment (group B). All patients underwent high-resolution B mode ultrasound to measure IMT of common carotid arteries before and after 6 months of vitamin supplementation. In group A, cIMT significantly decreased after treatment, whereas no significant changes were observed in group B. In conclusion, our results demonstrate a beneficial effect of the treatment of hyperhomocysteinemia by vitamin supplementation on an early sign of atherosclerosis in a group of renal transplant recipients.
authors.affiliation: Surgical and Medical Critical Care, Clinica Medica Generale e Cliniche Specialistiche, University of Florence, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Marcucci
authors.forename: M
authors.initials: M
authors.lastname: Zanazzi
authors.forename: E
authors.initials: E
authors.lastname: Bertoni
authors.forename: A
authors.initials: A
authors.lastname: Rosati
authors.forename: S
authors.initials: S
authors.lastname: Fedi
authors.forename: M
authors.initials: M
authors.lastname: Lenti
authors.forename: D
authors.initials: D
authors.lastname: Prisco
authors.forename: S
authors.initials: S
authors.lastname: Castellani
authors.forename: R
authors.initials: R
authors.lastname: Abbate
authors.forename: M
authors.initials: M
authors.lastname: Salvadori
mesh_terms: D002339:Carotid Arteries / Q000473:pathology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000188:drug therapy*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D010919:Placebos; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D014815:Vitamins; D006710:Homocysteine