Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
Bánvölgyi
Agnes
A
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, H-7624 Pécs, Szigeti. u. 12, Hungary.
Pálinkás
László
L
Berki
Tímea
T
Clark
Natalie
N
Grant
Andrew D
AD
Helyes
Zsuzsanna
Z
Pozsgai
Gábor
G
Szolcsányi
János
J
Brain
Susan D
SD
Pintér
Erika
E
D000276:Adjuvants, Immunologic / Q000633:toxicity; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000172:deficiency / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D004195:Disease Models, Animal; D004224:Diterpenes / Q000008:administration & dosage; D004427:Ear Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009504:Neutrophils / Q000378:metabolism; D010081:Oxazolone / Q000633:toxicity*; D010880:Piperidines / Q000008:administration & dosage; D011812:Quinuclidines / Q000008:administration & dosage; D050916:TRPV Cation Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000502:physiology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004224:Diterpenes; D010880:Piperidines; D011812:Quinuclidines; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; C085215:SR 140333; D010081:Oxazolone; C024353:resiniferatoxin; D015740:Calcitonin Gene-Related Peptide