title: Mucosal and systemic antibody responses in humans infected with simian foamy virus.
abstract: Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.
authors.affiliation: HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. cummins@sri.org
authors.forename: James E
authors.initials: JE
authors.lastname: Cummins
authors.forename: Roumiana S
authors.initials: RS
authors.lastname: Boneva
authors.forename: William M
authors.initials: WM
authors.lastname: Switzer
authors.forename: Logan L
authors.initials: LL
authors.lastname: Christensen
authors.forename: Paul
authors.initials: P
authors.lastname: Sandstrom
authors.forename: Walid
authors.initials: W
authors.lastname: Heneine
authors.forename: Louisa E
authors.initials: LE
authors.lastname: Chapman
authors.forename: Charlene S
authors.initials: CS
authors.lastname: Dezzutti
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis* / Q000097:blood / Q000652:urine; D000918:Antibody Specificity; D015683:Gene Products, gag / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood / Q000652:urine; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood / Q000652:urine; D010306:Parotid Gland / Q000378:metabolism; D012192:Retroviridae Infections / Q000097:blood / Q000276:immunology* / Q000652:urine; D012463:Saliva / Q000276:immunology; D016092:Spumavirus / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D015683:Gene Products, gag; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014764:Viral Proteins