title: 201Tl myocardial SPECT detects significant coronary artery disease between 50% and 75% angiogram stenosis.
abstract: Coronary angiography is the "gold standard" for the diagnosis of coronary artery disease (CAD). The aim of this work was to compare 201Thallium SPECT with different coronary angiographic cutoff values.
  
  
  METHODS
  Data pertaining to 145 patients were tabulated. All patients underwent stress ECG, 201Thallium SPECT and coronary angiography. To assess the cutoff impact, two criteria for coronary angiography diagnosis were used: a) > or = 50% and b) > or = 75% stenosis, and applied to data from patients and vessels.
  
  
  RESULTS
  On a patient basis, 201Thallium SPECT sensitivity, specificity and accuracy were 87%, 57% and 81% with > or = 50% cutoff and 93%, 51% and 79% with > or = 75% cutoff, respectively (NS). When performing individual vessel analysis, sensitivity, specificity and accuracy were 59%, 78% and 68% for > or = 50% cutoff and 70%, 75% and 74% for > or = 75% cutoff, respectively (p < 0.029 for sensitivity). As expected, the severer the stenosis the higher the detection rate. There were 19 patients who had stenosis between 50% and 74%. Of these, 21% had abnormal stress ECG and 58% abnormal Thallium-201 SPECT.
  
  
  CONCLUSIONS
  201Thallium SPECT results support the use of > or = 50% stenosis cutoff criteria for CAD diagnosis and evaluation. Combined with coronary angiography, myocardial SPECT offers an excellent management strategy to patients.
authors.affiliation: Nuclear Medicine Section, University of Chile, Santiago, Chile. ajgonzalez@manquehue.net
authors.forename: P
authors.initials: P
authors.lastname: González
authors.forename: T
authors.initials: T
authors.lastname: Massardo
authors.forename: M J
authors.initials: MJ
authors.lastname: Jofré
authors.forename: J
authors.initials: J
authors.lastname: Yovanovich
authors.forename: H
authors.initials: H
authors.lastname: Prat
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Arriagada
authors.forename: W
authors.initials: W
authors.lastname: Anzoátegui
authors.forename: A R
authors.initials: AR
authors.lastname: Carmona
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes