[The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma].
OBJECTIVE
To investigate the effect of neoadjuvant chemotherapy on estrogen receptor (ER) and progesterone receptor (PR) expression in breast carcinoma.


METHODS
Samples were obtained from 31 patients with breast carcinoma who received neo-adjuvant chemotherapy, ER or PR expressions were analyzed in preoperative core biopsies and final surgical specimens.


RESULTS
ER level was up-regulated in 13 (41.9%) out of 31 cases, PR level was up-regulated in 10 (32.3%). Both ER level and PR level were up-regulated in 8 (25.8%) out of 31 cases.


CONCLUSIONS
Neoadjuvant chemotherapy may impact the hormone receptor status, ER and PR expression re-analysis in final surgical specimens is recommended.
Wang
Shu
S
Department of Breast, People's Hospital, Peking University, Beijing 100044, China. dr.wangshu@263.net
Zhang
Jia-qing
JQ
Qiao
Xin-min
XM
Yang
De-qi
DQ
Tong
Fu-zhong
FZ
Liu
Hong-jun
HJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D017024:Chemotherapy, Adjuvant; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D020360:Neoadjuvant Therapy; D017239:Paclitaxel / Q000008:administration & dosage; D011960:Receptors, Estrogen / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015251:Epirubicin; D017239:Paclitaxel