Embolization-driven occlusion of the abdominal aortic aneurysmal sac as the basis of prevention of endoleaks in a new swine model.
OBJECTIVE
To assess the effect of a new polymer in embolization of endoleaks using an animal model.


METHODS
A modified aortic stent-graft was placed in 20 pigs. Embolization was performed at the time of graft insertion with non-cytotoxic n-butyl-2-cyanoacrylate-metacryloxysulpholane and lipiodol (0.2:0.8ratio, 2 ml). Angiography, scanning electron microscopy and immuno-histochemistry were obtained at day 0, 1 week and 3 months.


RESULTS
In control animals both type I and II endoleaks were demonstrated. In treated animals, neither type-I nor type-II endoleaks were observed and a fibro-proliferative response was demonstrated within the aneurysm thrombus.


CONCLUSIONS
Host vascular responses govern the fate of the excluded aneurysm. Embolization of the sac and feeding arteries with non-cytotoxic glue sealed all occlusions by stimulating a massive restenosis-like process.
Rolland
P H
PH
Laboratory of Hemodynamics and Cardiovascular Mechanics, School of Medicine, La Timone Hospital for Adults, Mediterranean See University and Department of Radiology, Marseilles, France. ph.rolland@medecine.univ-mrs.fr
Vidal
V
V
Mekkaoui
C
C
Bertrand
M-F
MF
Levrier
O
O
Bartoli
J-M
JM
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D001027:Aortography; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D003287:Contrast Media / Q000627:therapeutic use; D003487:Cyanoacrylates / Q000627:therapeutic use; D004195:Disease Models, Animal; D004338:Drug Combinations; D004621:Embolization, Therapeutic / Q000379:methods*; D007459:Iodized Oil / Q000627:therapeutic use; D008297:Male; D008855:Microscopy, Electron, Scanning; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D011475:Prosthesis Failure; D015607:Stents; D013552:Swine
D003287:Contrast Media; D003487:Cyanoacrylates; D004338:Drug Combinations; C421461:glubran 2; D007459:Iodized Oil