[Cytochrome P450/epoxyeicosatrienoic acids system and myocardial ischemic-reperfusion injury].
Interests on the effects of cytochrome P450 (CYP450) monooxygenases and epoxyeicosatrienoic acids (EETs) on myocardial ischemic-reperfusion injury has been increased in recent years. The CYP450/EET system may influence the degree of myocardial ischemic-reperfusion injury through "poly-targets", such us oxygen free radical, calcium overload, leukocytes adherence, nitric oxide, ATP-sensitive K+ channels, and mitogen activated protein kinase. The exaggeration or recovery of injury depends on the physical status. Study of factors that affects CYP450/EET, particularly identification of their involvement in cardioprotective signaling and specific roles, will elucidate the mechanisms of myocardial ischemic-reperfusion injury, and find a new way of prevention and treatment. This article will review the relationship between the changes of CYP450/EETs system and myocardial ischemic-reper-
Zhang
Li-Ke
LK
Department of Pathophysiology, Capital University of Medical Sciences, Beijing 100054, China. bingshen@cpums.edu.cn
Tang
Chao-Shu
CS
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000378:metabolism*; D006801:Humans; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000378:metabolism
D003577:Cytochrome P-450 Enzyme System; D015118:Eicosapentaenoic Acid; D006899:Mixed Function Oxygenases