title: A novel route to fully substituted 1H-pyrazoles.
abstract: A novel one-step synthesis route to fully substituted pyrazol-4-ols is reported. This simple yet nonobvious method for the construction of pyrazol-4-ols by the condensation-fragmentation-cyclization-extrusion reactions of thietanones with 1,2,4,5-tetrazines is reported. All of the elements of the thietanone except its sulfur are incorporated in these novel products.
authors.affiliation: Department of Chemistry, University of California, Davis, California 95616, USA.
authors.forename: Yat Fan
authors.initials: YF
authors.lastname: Suen
authors.forename: Håkon
authors.initials: H
authors.lastname: Hope
authors.forename: Michael H
authors.initials: MH
authors.lastname: Nantz
authors.forename: Makhluf J
authors.initials: MJ
authors.lastname: Haddadin
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D011720:Pyrazoles; D006859:Hydrogen