In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867.
The in vitro activities of DA-7867, a novel oxazolidinone, and garenoxacin (BMS-284756) were compared to those of linezolid in 67 susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis. DA-7867 was the most active drug with an MIC(90) of 0.125 microg/ml, compared to the MIC(90)s of 4 microg/ml of garenoxacin and 2 microg/ml of linezolid.
Vera-Cabrera
Lucio
L
Servicio de Dermatología, Hospital Universitario, José E. González, Madero y Gonzalitos, Col. Mitras Centro, Monterrey, NL, México. luvera_99@yahoo.com
Castro-Garza
Jorge
J
Rendon
Adrian
A
Ocampo-Candiani
Jorge
J
Welsh
Oliverio
O
Choi
Sung Hak
SH
Blackwood
Kym
K
Molina-Torres
Carmen
C
D000081:Acetamides / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D024841:Fluoroquinolones / Q000494:pharmacology*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D023303:Oxazolidinones / Q000494:pharmacology*
D000081:Acetamides; D000995:Antitubercular Agents; C480487:DA-7867; D024841:Fluoroquinolones; D023303:Oxazolidinones; D000069349:Linezolid; C419689:garenoxacin