[Immunomodulating effects induced by the regulators of energy metabolism and the exposure to heat and cold in case of toxic affection of the kidneys].
The injection of HgCl2 to Wistar rats results in the affection of the excretory renal function, the development of immunosuppressive properties of red blood cells and the depression of immunological functions. The exposure to heat in combination with the injection of thiamin and inosin caused normalization of the immunological parameters of the intoxicated animals. The exposure to cold aggravates the severity of the immunological abnormalities induced by the injection of HgCl2. Thiamin in combination with inosin and carnitin with biotin significantly weaken the immunological disorders caused by intoxication and cooling.
Lazareva
G A
GA
Brovkina
I L
IL
D000818:Animals; D001710:Biotin / Q000494:pharmacology; D002331:Carnitine / Q000494:pharmacology; D003080:Cold Temperature; D004734:Energy Metabolism / Q000187:drug effects; D006358:Hot Temperature; D007107:Immune System / Q000276:immunology; D007288:Inosine / Q000494:pharmacology; D008627:Mercuric Chloride / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000276:immunology*; D013831:Thiamine / Q000494:pharmacology; D014803:Vitamin B Complex / Q000494:pharmacology*
D014803:Vitamin B Complex; D008627:Mercuric Chloride; D007288:Inosine; D001710:Biotin; D002331:Carnitine; D013831:Thiamine