title: [Metformin-associated lactic acidosis in a patient with pre-existing risk factors].
abstract: Lactic acidosis is a serious clinical situation associated with a high case fatality rate. Lactic acidosis is particularly found in conditions with an insufficient supply of oxigen in the tissue. Other causes for lactic acidosis can be hepatic or renal insufficiency. For the therapy of overweight patients with type 2 diabetes metformin is the first choice if diet and physical training have been ineffective. Metformin, however, has the potential to increase serumlactate. Therefore its ability to cause lactic acidosis is controversely discussed. We present a 64-year-old female patient with metformin-associated lactic acidosis. She had several pre-existing risk factors to develop a lactic acidosis. On her referral to the hospital she suffered from acute renal failure which is considered to be a contraindication for the use of metformin.
authors.affiliation: Klinische Pharmakologie & Toxikologie, Universitätsspital Basel, Medizinische Universitätsklinik, Kantonsspital Liestal. beckerc@uhbs.ch
authors.forename: C
authors.initials: C
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Luginbühl
authors.forename: U
authors.initials: U
authors.lastname: Pittl
authors.forename: R
authors.initials: R
authors.lastname: Schlienger
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis; D000075202:Contraindications; D048909:Diabetes Complications / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects*; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin