The effects of perioperative pain management techniques on food consumption and body weight after laparotomy in rats.
We examined the effects of two perioperative pain management techniques on recovery after laparotomy, as assessed by body weight (BW) and food consumption (FC). All rats received a preoperative intrathecal mixture of morphine plus bupivacaine combined with one of two treatments: (a) injection of slow-release morphine at the end of the surgery or (b) an antiinflammatory drug, interleukin-1 receptor antagonist (IL-1ra), combined with the preoperative mixture. Laparotomy significantly decreased FC and BW. Both analgesic treatments resulted in a faster recovery of FC and BW. This beneficial effect was more pronounced in the group receiving preoperative analgesics combined with IL-1ra.


CONCLUSIONS
Effective perioperative pain management can improve postoperative recovery. We studied the effects of two preoperative pain management techniques on recovery after laparotomy in rats. Both analgesic treatments resulted in a faster recovery, especially preoperative analgesics combined with interleukin-1 receptor antagonist.
Shavit
Yehuda
Y
*Department of Psychology, Hebrew University, Jerusalem; and †Department of Anesthesiology, Rabin Medical Center, Golda-Hasharon Campus, Petah Tiqva, affiliated with the Sackler School of Medicine, Tel-Aviv University, Israel.
Fish
Gila
G
Wolf
Gilly
G
Mayburd
Eduard
E
Meerson
Ylia
Y
Yirmiya
Raz
R
Beilin
Benzion
B
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002045:Bupivacaine / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004435:Eating / Q000187:drug effects*; D053590:Interleukin 1 Receptor Antagonist Protein; D007813:Laparotomy; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344; D012795:Sialoglycoproteins / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D053590:Interleukin 1 Receptor Antagonist Protein; D012795:Sialoglycoproteins; D009020:Morphine; D002045:Bupivacaine