title: Electrophilic cyclization of 2-(1-alkynyl)-2-alken-1-ones using the I2/K3PO4 system: an efficient synthesis of highly substituted iodofurans.
abstract: [reaction: see text] The electrophilic cyclization of 2-(1-alkynyl)-2-alken-1-ones in the presence of various alcohols or carbon-based nucleophiles offers an efficient and straightforward route to highly substituted iodofurans under extremely mild reaction conditions. The iodo derivatives are potential synthetic intermediates for amplification of molecular complexity.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China. yhliu@mail.sioc.ac.cn
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Shaolin
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003500:Cyclization; D003516:Cycloparaffins / Q000737:chemistry*; D004563:Electrochemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D017680:Potassium Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003516:Cycloparaffins; D005663:Furans; D010710:Phosphates; D017680:Potassium Compounds; D007455:Iodine; C013216:potassium phosphate