title: Fetal and neonatal consequences of antenatal exposure to type 1 angiotensin II receptor-antagonists.
abstract: Sartans are selective type 1 angiotensin II receptor-antagonists that are used in the treatment of arterial hypertension. Few reports are available concerning the use of sartans during pregnancy. We report two cases of adverse fetal outcome in hypertensive pregnancies exposed to sartans. In the first case, anamnios and fetal renal failure due to severe tubular dysgenesia led to termination of pregnancy in the 27th week. The second patient presented with hypocalvaria and developed fetal renal failure. The use of sartans during the two last trimesters of pregnancy should be strictly avoided.
authors.affiliation: Department of Neonatology, Hôpital de la Timone-Enfants, Marseille, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Vendemmia
authors.forename: Patricia
authors.initials: P
authors.lastname: Garcia-Méric
authors.forename: Alina
authors.initials: A
authors.lastname: Rizzotti
authors.forename: Farid
authors.initials: F
authors.lastname: Boubred
authors.forename: Valérie
authors.initials: V
authors.lastname: Lacroze
authors.forename: Agnès
authors.initials: A
authors.lastname: Liprandi
authors.forename: Umberto
authors.initials: U
authors.lastname: Simeoni
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011859:Radiography
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II