ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.
One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of drugs by pumping a variety of drugs out cells at the expense of ATP hydrolysis. One strategy for reversal of the resistance of tumor cells expressing ABC transporters is combined use of anticancer drugs with chemosensitizers. In this review, the physiological functions and structures of ABC transporters, and the development of chemosensitizers are described focusing on well-known proteins including P-glycoprotein, multidrug resistance associated protein, and breast cancer resistance protein.
Choi
Cheol-Hee
CH
Research Center for Resistant Cells, Chosun University Medical School, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, South Korea. chchoi@chosun.ac.kr