Comparison of target concentration intervention strategy with conventional dosing of digoxin.
Digoxin is a widely used drug in patients with congestive heart failure. The present study compared the quality of life of congestive heart failure patients on one year follow-up period with two different dosing of digoxin (5/7 therapy and 7/7 therapy in whom the target serum digoxin concentration is maintained). Quality of life significantly improved in intervention group thus emphasizing the need for continuous dosing of digoxin based on target concentration.
Rajendran
S D
SD
Department of Pharmacy Practice, JSS College of Pharmacy, Ootacamund 643 001. sdrajendran@rediffmail.com
Rao
Y Madhusudan
YM
Thanikachalam
S
S
Muralidharan
T R
TR
Anbalagan
M
M
D002316:Cardiotonic Agents / Q000097:blood / Q000627:therapeutic use; D016022:Case-Control Studies; D004077:Digoxin / Q000097:blood* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D002316:Cardiotonic Agents; D004077:Digoxin