Hairless triggers reactivation of hair growth by promoting Wnt signaling.
The mammalian hair cycle involves periodic regeneration of a tiny organ, the hair follicle, through a stem-cell-mediated process. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is essential for hair follicle regeneration, but its role in this process is unknown. Here, we demonstrate that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in Hr(-/-) mice. We show that expression of Wise, a modulator of Wnt signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. This work links HR and Wnt function, providing a model in which HR regulates the precise timing of Wnt signaling required for hair follicle regeneration.
Beaudoin
Gerard M J
GM
Kennedy Krieger Research Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sisk
Jeanne M
JM
Coulombe
Pierre A
PA
Thompson
Catherine C
CC
D000818:Animals; D015153:Blotting, Western; D018859:Hair Follicle / Q000502:physiology*; D017403:In Situ Hybridization; D015603:Keratinocytes / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D012038:Regeneration / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism*; D014162:Transfection; D051153:Wnt Proteins / Q000378:metabolism*
D014157:Transcription Factors; D051153:Wnt Proteins; C088661:hr protein, mouse