Robust trend tests for genetic association using matched case-control design.
Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.
Zheng
Gang
G
Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. zhengg@nhlbi.nih.gov
Tian
Xin
X
D044383:Black People; D016022:Case-Control Studies; D003198:Computer Simulation; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012507:Sarcoidosis / Q000235:genetics; D044465:White People
D007136:Immunoglobulins