title: A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice.
abstract: Stratifin (Sfn, also called 14-3-3sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice.
authors.affiliation: Genomics Institute, Wadsworth Center, NYS Dept. of Health, 465 Jordan Road, Albany, New York 12180, USA. bherron@wadsworth.org
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Herron
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Liddell
authors.forename: April
authors.initials: A
authors.lastname: Parker
authors.forename: Sarah
authors.initials: S
authors.lastname: Grant
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kinne
authors.forename: Jill K
authors.initials: JK
authors.lastname: Fisher
authors.forename: Linda D
authors.initials: LD
authors.lastname: Siracusa
mesh_terms: D048948:14-3-3 Proteins; D000505:Alopecia / Q000235:genetics* / Q000473:pathology; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D000078404:Epidermal Cells; D005092:Exonucleases / Q000235:genetics*; D005095:Exoribonucleases; D006204:Hair Removal; D006579:Heterozygote; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000033:anatomy & histology*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D010641:Phenotype; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human