Colonic and small-intestinal phenotypes in gastric cancers: relationships with clinicopathological findings.
The clinicopathological significance of colonic and small-intestinal phenotypes has hitherto remained unclear in gastric cancers. The purpose of the present study was therefore to examine 86 gastric carcinomas histologically and phenotypically using several phenotypic markers, including colon-specific carbonic anhydrase 1 (CA1) and sucrase as small-intestine specific marker. Of 86 gastric cancers, sucrase and CA1 expression was observed in 12 (14.0%) and only in two cases (2.3%), respectively, associated with other intestinal markers such as villin and mucin core protein (MUC)2. In the sucrase cases, expression appeared independent of the stage. However, CA1 expression was observed only in two advanced cases. No association was observed between colonic and small-intestinal phenotypes, and lymph node metastasis and postoperative survival in the advanced gastric cancer cases with intestinal phenotypic expression. Cdx2 appeared to be linked to upregulation of both CA1 and sucrase. In conclusion, the data suggest that colonic phenotype occurs rarely in gastric carcinogenesis. Colonic and small-intestinal phenotypes appear with expression of several intestinal phenotypic markers under the control of Cdx2 and presumably other related transcription factors.
Mizoshita
Tsutomu
T
Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya City University Medical School, Japan.
Tsukamoto
Tetsuya
T
Tanaka
Harunari
H
Takenaka
Yoshiharu
Y
Kato
Sosuke
S
Cao
Xueyuan
X
Joh
Takashi
T
Tatematsu
Masae
M
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D000071616:CDX2 Transcription Factor; D024401:Carbonic Anhydrase I / Q000378:metabolism; D003106:Colon / Q000378:metabolism* / Q000473:pathology; D005260:Female; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007421:Intestine, Small / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D009077:Mucins / Q000378:metabolism; D010641:Phenotype; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D013393:Sucrase / Q000378:metabolism
D014408:Biomarkers, Tumor; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; C524678:MUC5AC protein, human; D055271:Mucin 5AC; D009077:Mucins; D013393:Sucrase; D024401:Carbonic Anhydrase I