[Effects of glutamine granules on immunofunction in trauma patients: a double-blind randomized controlled, multi-center clinical trail with 120 patients].
OBJECTIVE
To evaluate the effect of glutamine granules on immunofunction in severe burns and trauma patients.


METHODS
One hundred and twenty patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients). There was isonitrogenous and isocaloric intake in both groups. GLN and P group patients had been given glutamine granules or placebo (glycine) at 0.5 g.kg(-1).d(-1) for 7 days, respectively. The level of plasma glutamine and some index of immunofunction were determined, and the complication and side effect were also observed.


RESULTS
After 7 days of taking glutamine granules orally, plasma GLN concentration was significantly higher than that in P group [(593 +/- 185) micromol/L vs (407 +/- 190) micromol/L)] (P < 0.01). IL-2 level, CD(4)/CD(8) ratio, PMN swallow ratio in GLN group were significantly higher than those in P group (P < 0.05-0.01), but the concentration of IgG, IgM, C(3)/C(4) were not significantly different when compared with P group (P > 0.05). In addition, the occurrence of side effect in both groups was seldom.


CONCLUSIONS
Taking glutamine granules could increase plasma GLN concentration, enhance body immunofunction, and using glutamine granules is safe.
Peng
Xi
X
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns Research, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
You
Zhong-yi
ZY
Huang
Xian-kai
XK
Zhang
Cai-quan
CQ
He
Guang-zhao
GZ
Quan
Zhu-fu
ZF
Xie
Wei-guang
WG
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005973:Glutamine / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014947:Wounds and Injuries / Q000097:blood / Q000188:drug therapy* / Q000276:immunology
D005973:Glutamine