title: The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development.
abstract: The members of the casein kinase 1 (CK1) family are highly conserved and are expressed in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Mutations and deregulation of CK1 expression and activity has been linked to various diseases including neurodegenerative disorders such as Alzheimer's and Parkinson's disease, sleeping disorders and proliferative diseases such as cancer. In this review, we summarize the functions of CK1 and outline the participation of CK1 in signal transduction pathways linked to cancer development.
authors.affiliation: Department of Visceral and Transplantation Surgery, University of Ulm, Germany. uwe.knippschild@medizin.uni-ulm.de
authors.forename: Uwe
authors.initials: U
authors.lastname: Knippschild
authors.forename: Sonja
authors.initials: S
authors.lastname: Wolff
authors.forename: Georgios
authors.initials: G
authors.lastname: Giamas
authors.forename: Claas
authors.initials: C
authors.lastname: Brockschmidt
authors.forename: Mathias
authors.initials: M
authors.lastname: Wittau
authors.forename: Peter Uwe
authors.initials: PU
authors.lastname: Würl
authors.forename: Thorsten
authors.initials: T
authors.lastname: Eismann
authors.forename: Martin
authors.initials: M
authors.lastname: Stöter
mesh_terms: D000818:Animals; D017209:Apoptosis; D047389:Casein Kinase I / Q000378:metabolism*; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology*; D020033:Protein Isoforms / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007527:Isoenzymes; D009363:Neoplasm Proteins; D020033:Protein Isoforms; D047389:Casein Kinase I