title: Influence of quantity of lymph vascular space invasion on time to recurrence in women with early-stage squamous cancer of the cervix.
abstract: OBJECTIVE
  To determine if the quantity of lymph vascular space invasion (LVSI) correlates with time to recurrence in women with early-stage squamous carcinoma of the cervix.
  
  
  METHODS
  101 consecutive women with Stages IA2, IB, and IIA squamous carcinoma of the cervix who had undergone radical hysterectomy between 1991 and 1997, with previously reported histopathologic quantification of LVSI by four methods, were prospectively followed. The outcome measure was time to recurrence. Univariate and stratified log-rank test analysis was performed to test the association of time to recurrence with prognostic factors. Further analysis was focused on recurrence in those patients who had negative surgical margins and whose tumors contained LVSI, incorporating the four quantification measures.
  
  
  RESULTS
  Nineteen (19%) women had cancer recurrence. The presence of LVSI (P = 0.05), cervical stromal invasion (P = 0.01), parametrial involvement (P < 0.001), and positive margins (P < 0.0001) were significantly related to time to recurrence on univariate analysis. In patients whose tumors had negative surgical margins and contained LVSI (65%), percentage of all sections with LVSI >29% and total number of foci with LVSI >5 were significantly related to time to recurrence (P = 0.006). When stratifying for cervical stromal invasion, lymph node status, and parametrial involvement in this group, percentage of all sections with LVSI >29% and total number of foci with LVSI >5 were significantly related to time to recurrence (P = 0.05).
  
  
  CONCLUSIONS
  The quantity of LVSI, as defined by the percentage of all sections with LVSI and total number of foci with LVSI, is an independent prognostic factor for time to recurrence in women with early-stage squamous carcinoma of the cervix.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Walter Reed Army Medical Center, 6900 Georgia Avenue, NW, Bldg. 2 Rm. 2 J-06, Washington, DC 20307-5001, USA. mildred.chernofsky@na.amedd.army.mil
authors.forename: Mildred R
authors.initials: MR
authors.lastname: Chernofsky
authors.forename: Juan C
authors.initials: JC
authors.lastname: Felix
authors.forename: Laila I
authors.initials: LI
authors.lastname: Muderspach
authors.forename: C Paul
authors.initials: CP
authors.lastname: Morrow
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.forename: Susan G
authors.initials: SG
authors.lastname: Groshen
authors.forename: Lynda D
authors.initials: LD
authors.lastname: Roman
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D002583:Uterine Cervical Neoplasms / Q000473:pathology*