Mycosis fungoides associated with intestinal mucosa-associated lymphoid tissue lymphoma.
Coexistence of cutaneous T-cell lymphoma (CTCL) and a B-cell malignancy is rare. We report a case of mycosis fungoides (MF) associated with intestinal mucosa-associated lymphoid tissue (MALT) lymphoma, which is a low-grade B-cell lymphoma of marginal cell origin. To the best of our knowledge, there have been only two cases of coexistent CTCL and MALT lymphoma, and this is the first case with typical MF and intestinal MALT lymphoma. The coexistence in our case might be coincidental, but genetic predisposition and the immunoregulatory capacity of neoplastic T lymphocytes may be factors contributing to this association.
Ohmatsu
Hanako
H
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. OMATSUH-DER@h.u-tokyo.ac.jp
Saeki
Hidehisa
H
Fujita
Hideki
H
Toyoma
Keiko
K
Sugaya
Makoto
M
Asahina
Akihiko
A
Masuda
Shigeo
S
Hirai
Hisamaru
H
Watanabe
Toshiaki
T
Nagawa
Hirokazu
H
Tamaki
Kunihiko
K
D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000032:analysis; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D014178:Translocation, Genetic
D018951:Antigens, CD20; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D007143:Immunoglobulin Heavy Chains; D016693:Receptors, Antigen, T-Cell, alpha-beta; D017493:Leukocyte Common Antigens