title: [Lysosomal carboxypeptidase A].
abstract: Lysosomal carboxypeptidase A (cathepsin A) is synthetized in the form of preproenzyme, which undergoes to active enzyme as a result of post-translational modification. It splits off C-terminal amino acid residues from peptides and proteins and synergizes with other proteases in degradation of cellular proteins in lysosomes. Lysosomal carboxypeptidase A has an effect on peptide hormones and peptides of biological activity of tissues and body fluids as well. It forms complexes with some glycosidases that protects them against proteolytic degradation. Deficiency of this enzyme induces storage diseases. Lysosomal carboxypeptidase A as multifunctional enzyme plays an important regulatory role in organismal metabolism.
authors.affiliation: Department of Vascular Surgery and Transplantation, Medical University of Białystok, 24a M. Skłodowska-Curie St., 15-269 Białystok, Poland. chirnacz@amb.edu.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Gacko
authors.forename: Anna
authors.initials: A
authors.lastname: Worowska
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Woźniak
authors.forename: Monika
authors.initials: M
authors.lastname: Jedynak
authors.forename: Bogusław
authors.initials: B
authors.lastname: Panek
authors.forename: Radosław
authors.initials: R
authors.lastname: Lapiński
mesh_terms: D000595:Amino Acid Sequence; D043422:Carboxypeptidases A / Q000378:metabolism*; D006801:Humans; D016464:Lysosomal Storage Diseases / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D011499:Protein Processing, Post-Translational
chemical_list: D043422:Carboxypeptidases A