Possibilities and limitations of quadrupole mass spectrometric detector in fast gas chromatography.
In this work the application and limitations of a common bench top quadrupole mass spectrometer was evaluated for the qualitative and quantitative measurement of n-alkanes and pesticides of a wide range of volatilities and polarities with fast GC separations using 0.15 mm I.D. narrow-bore capillary columns. It was found that the spectra acquisition rate has a great impact on sensitivity (peak areas, peak shapes and S/N ratios). The quality of the obtained spectra is not significantly influenced in the full scan monitoring mode for the fastest scan rates. For quantitative analysis a selected ion monitoring mode is able to acquire the sufficient number of data-points for the proper peak shape reconstruction and good repeatability of peak areas measurements expressed by RSD (< 5%) for all tested dwell times shorter than 75 ms. However, for shorter dwell times, S/N ratio is lower, while peak areas are not influenced.
Kirchner
Michal
M
Department of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, Bratislava 812 37, Slovak Republic.
Matisová
Eva
E
Hrouzková
Svetlana
S
de Zeeuw
Jaap
J
D000473:Alkanes / Q000302:isolation & purification; D002849:Chromatography, Gas / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation*; D013058:Mass Spectrometry / Q000295:instrumentation; D010575:Pesticides / Q000302:isolation & purification
D000473:Alkanes; D010575:Pesticides