[Role of AURE sequences in the regulation of mRNA stability].
Post-transcriptional processes influencing mRNA stability are an important control point in gene expression regulation. The best-studied regulatory elements controlling mRNA stability are AU-rich sequences (AURE) found in 3'UTRs of many genes coding cytokines and stress response proteins. The presence of these elements results in short half-life of mRNA, but such mRNA half-life is prolonged upon cell stimulation or exposition to stress factors. Research on AURE-mediated mRNA decay resulted in discovery of AURE-binding proteins and in elucidating signal transduction pathways involved in the process of mRNA stability regulation. Defects in mRNA stability regulation can result in diseases such as lymphomas, neuromas or immunological and inflammatory disorders.
Trzaska
Dominika
D
Laboratory of Molecular Immunology, International Institute of Molecular and Cell Biology, 4 Ks. Trojdena St., 02-109 Warsaw, Poland. nika@iimcb.gov.pl
Dastych
Jarosław
J
D000227:Adenine Nucleotides / Q000378:metabolism*; D001483:Base Sequence; D005786:Gene Expression Regulation; D006801:Humans; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*; D017423:Sequence Analysis, RNA; D015398:Signal Transduction; D014500:Uracil Nucleotides / Q000378:metabolism*
D000227:Adenine Nucleotides; D012333:RNA, Messenger; D014500:Uracil Nucleotides