AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters.
We cloned a gene, abeM, for a multidrug efflux pump from Acinetobacter baumannii using Escherichia coli as the host. Sequence analysis revealed that AbeM is a member of the MATE family of pumps. AbeM was found to be an H(+)-coupled multidrug efflux pump and a unique member of the MATE family.
Su
Xian-Zhong
XZ
Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Chen
Jing
J
Mizushima
Tohru
T
Kuroda
Teruo
T
Tsuchiya
Tomofusa
T
D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology; D017920:Antiporters / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001692:Biological Transport; D003001:Cloning, Molecular; D004269:DNA, Bacterial; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development; D005798:Genes, Bacterial; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D017494:Proton Pumps / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D013379:Substrate Specificity
D000900:Anti-Bacterial Agents; D017920:Antiporters; D004269:DNA, Bacterial; D017494:Proton Pumps