title: In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy.
abstract: Scanning-laser ophthalmoscopy is a technique for confocal imaging of the eye in vivo. The use of lasers of different wavelengths allows to obtain information about specific tissues and layers due to their reflection and transmission characteristics. In addition, fluorescent dyes excitable in the blue and infrared range offer a unique access to the vascular structures associated with each layer. In animal models, a further enhancement in specificity can be obtained by GFP expression under control of tissue-specific promotors. Important fields of application are studies in retinal degenerations and the follow-up of therapeutic intervention.
authors.affiliation: Retinal Diagnostics Research Group, Tuebingen, Germany. see@uni-tuebingen.de
authors.forename: Mathias W
authors.initials: MW
authors.lastname: Seeliger
authors.forename: Susanne C
authors.initials: SC
authors.lastname: Beck
authors.forename: Naira
authors.initials: N
authors.lastname: Pereyra-Muñoz
authors.forename: Susann
authors.initials: S
authors.lastname: Dangel
authors.forename: Jen-Yue
authors.initials: JY
authors.lastname: Tsai
authors.forename: Ulrich F O
authors.initials: UF
authors.lastname: Luhmann
authors.forename: Serge A
authors.initials: SA
authors.lastname: van de Pavert
authors.forename: Jan
authors.initials: J
authors.lastname: Wijnholds
authors.forename: Marijana
authors.initials: M
authors.lastname: Samardzija
authors.forename: Andreas
authors.initials: A
authors.lastname: Wenzel
authors.forename: Eberhart
authors.initials: E
authors.lastname: Zrenner
authors.forename: Kristina
authors.initials: K
authors.lastname: Narfström
authors.forename: Edda
authors.initials: E
authors.lastname: Fahl
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Tanimoto
authors.forename: Niyazi
authors.initials: N
authors.lastname: Acar
authors.forename: Felix
authors.initials: F
authors.lastname: Tonagel
mesh_terms: D000818:Animals; D005451:Fluorescein Angiography; D007208:Indocyanine Green; D007834:Lasers; D051379:Mice; D018613:Microscopy, Confocal / Q000295:instrumentation / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods*; D023421:Models, Animal; D009887:Ophthalmoscopy / Q000379:methods*; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000473:pathology*
chemical_list: D007208:Indocyanine Green