title: Strong evidence that daily use of fluoride toothpaste prevents caries.
abstract: METHODS
  Medline, Cochrane Library, reference lists of identified articles and selected textbooks were used to source studies.
  
  
  METHODS
  Selected studies were randomized or controlled clinical trials of at least 2 years' duration with caries increment in the permanent (DMFS/T) or primary (dmfs/t) dentition as the endpoint. Reports published in Danish, English, French, German, Italian, Norwegian, Spanish or Swedish were included. For multiply reported trials the one with the longest follow-up period was included.
  
  
  METHODS
  Inclusion decisions and grading of the studies was performed independently by two of the authors. The main outcome was prevented fraction (PF). A pooled estimate was calculated for included studies.
  
  
  RESULTS
  Fifty-four studies were included. There was strong evidence for a caries-preventive effect of daily use of fluoride toothpaste compared with placebo in the young permanent dentition (PF, 24.9%; standard deviation, +/-11.5%). Toothpastes containing 1500 ppm of fluoride had a superior preventive effect (additional PF, 9.7%; range 0-22%) compared with standard dentifrices of 1000 ppm fluoride. There was also strong evidence for higher caries reductions with supervised toothbrushing compared with unsupervised brushing. There was incomplete evidence regarding the effect of fluoride toothpaste in the primary dentition.
  
  
  CONCLUSIONS
  This review reinforces the importance of daily toothbrushing with fluoridated toothpastes for preventing dental caries, although long-term studies in age groups other than children and adolescents are still lacking.
authors.affiliation: Dental Health Services Research Unit, University of Dundee, Dundee, Scotland, UK.
authors.forename: Gail
authors.initials: G
authors.lastname: Topping
authors.forename: Andrea
authors.initials: A
authors.lastname: Assaf