A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.
The human eye is an important target for infection with herpes simplex virus 1 (HSV-1). Damage to cells forming the trabeculum of the eye by HSV-1 infection could contribute to the development of glaucoma, a major blinding disease. Primary cultures of human trabecular meshwork cells were used as an in vitro model to demonstrate the ability of HSV-1 to enter into and establish a productive infection of the trabeculum. Blocking of entry by anti-herpesvirus entry mediator (HVEM) antibody implicated HVEM as the major receptor for HSV-1 infection.
Tiwari
Vaibhav
V
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 60612, UK.
Clement
Christian
C
Scanlan
Perry M
PM
Kowlessur
Devanand
D
Yue
Beatrice Y J T
BY
Shukla
Deepak
D
D015815:Cell Adhesion Molecules / Q000378:metabolism; D002478:Cells, Cultured; D004279:DNA, Viral / Q000235:genetics; D006561:Herpes Simplex / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D018613:Microscopy, Confocal; D000075983:Nectins; D016133:Polymerase Chain Reaction; D011991:Receptors, Virus / Q000378:metabolism / Q000502:physiology*; D015238:Sulfotransferases / Q000378:metabolism; D014129:Trabecular Meshwork / Q000378:metabolism / Q000821:virology*; D014759:Viral Envelope Proteins / Q000378:metabolism; D014779:Virus Replication
D015815:Cell Adhesion Molecules; D004279:DNA, Viral; D000075983:Nectins; D011991:Receptors, Virus; D014759:Viral Envelope Proteins; C039447:glycoprotein D, Human herpesvirus 1; D015238:Sulfotransferases