Polymorphisms in four genes related to triglyceride and HDL-cholesterol levels in the general Japanese population in 2000.
We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G --> A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (-514 --> CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.
Arai
Hidenori
H
Department of Geriatric Medicine, Kyoto University School of Medicine, 54 Kawahara-cho, Shogoin, Sakuo-ku, Kyoto 606-8507, Japan. harai@kuhp.kyoto-u.ac.jp
Yamamoto
Akira
A
Matsuzawa
Yuji
Y
Saito
Yasushi
Y
Yamada
Nobuhiro
N
Oikawa
Shinichi
S
Mabuchi
Hiroshi
H
Teramoto
Tamio
T
Sasaki
Jun
J
Nakaya
Noriaki
N
Itakura
Hiroshige
H
Ishikawa
Yuichi
Y
Ouchi
Yasuyoshi
Y
Horibe
Hiroshi
H
Egashira
Tohru
T
Hattori
Hiroaki
H
Shirahashi
Nobuo
N
Kita
Toru
T
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008049:Lipase / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics*; D008071:Lipoprotein Lipase / Q000235:genetics; D008297:Male; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood / Q000235:genetics*
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D006023:Glycoproteins; C504173:LIPC protein, human; D014280:Triglycerides; D008049:Lipase; D008071:Lipoprotein Lipase