title: Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases.
abstract: Pyrimido-oxazepine based sub-micromolar inhibitors (2-4) for Aurora and FLT-3 were designed and synthesized. These preliminary results supported the potential use of pyrimido-oxazepines as a versatile template for developing specific kinase inhibitors.
authors.affiliation: Department of Chemistry, ImClone Systems Incorporated, 710 Parkside Avenue, Brooklyn, NY 11226, USA.
authors.forename: Weitao
authors.initials: W
authors.lastname: Pan
authors.forename: Hu
authors.initials: H
authors.lastname: Liu
authors.forename: Yong-Jiang
authors.initials: YJ
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Ki Hwan
authors.initials: KH
authors.lastname: Kim
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Milligan
authors.forename: John
authors.initials: J
authors.lastname: Columbus
authors.forename: Yaron R
authors.initials: YR
authors.lastname: Hadari
authors.forename: Paul
authors.initials: P
authors.lastname: Kussie
authors.forename: Wai C
authors.initials: WC
authors.lastname: Wong
authors.forename: Marc
authors.initials: M
authors.lastname: Labelle
mesh_terms: D064127:Aurora Kinases; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D010077:Oxazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D010077:Oxazepines; D011743:Pyrimidines; D010770:Phosphotransferases; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases