Mucosal and systemic antibody responses in humans infected with simian foamy virus.
Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.
Cummins
James E
JE
HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. cummins@sri.org
Boneva
Roumiana S
RS
Switzer
William M
WM
Christensen
Logan L
LL
Sandstrom
Paul
P
Heneine
Walid
W
Chapman
Louisa E
LE
Dezzutti
Charlene S
CS
D000914:Antibodies, Viral / Q000032:analysis* / Q000097:blood / Q000652:urine; D000918:Antibody Specificity; D015683:Gene Products, gag / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood / Q000652:urine; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood / Q000652:urine; D010306:Parotid Gland / Q000378:metabolism; D012192:Retroviridae Infections / Q000097:blood / Q000276:immunology* / Q000652:urine; D012463:Saliva / Q000276:immunology; D016092:Spumavirus / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology
D000914:Antibodies, Viral; D015683:Gene Products, gag; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014764:Viral Proteins