title: Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease.
abstract: We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Porter Neuroscience Building, 35 Convent Drive, Bethesda, MD 20892 3707, USA.
authors.forename: Omanma
authors.initials: O
authors.lastname: Adighibe
authors.forename: Sampath
authors.initials: S
authors.lastname: Arepalli
authors.forename: Jaime
authors.initials: J
authors.lastname: Duckworth
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Fabienne
authors.initials: F
authors.lastname: Wavrant-De Vrièze
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000453:epidemiology* / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D002869:Chromosome Aberrations; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D014644:Genetic Variation / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D000071518:Liver X Receptors; D008297:Male; D008875:Middle Aged; D057093:Orphan Nuclear Receptors; D011110:Polymorphism, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D001057:Apolipoproteins E; D000071518:Liver X Receptors; C000605210:NR1H2 protein, human; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear