title: [African histoplasmosis (Histoplasma capsulatum var. duboisii): a case report from Mali].
abstract: We report a case of disseminated African histoplasmosis with lymph node and digestive involvement in a 19-year-old man living in the Kayes district of Mali. The patient, HIV-seronegative and not otherwise immunocompromised, presented voluminous cervical and axillary adenopathies as well as retrosternal and mesenteric tumor lesions. Direct examination of biopsy tissue showed numerous specimens of Histoplasma capsulatum var. duboisii. Because direct fungal techniques are the easiest and the most effective method of diagnostic investigation, no cultures were performed. Intolerance to therapy with amphotericin b and ketoconazole led its rapid replacement by surgical treatment: partial excision of the abdominal lesions led to partial remission of the symptoms.
authors.affiliation: Service de maladies infectieuses, Hôpital du point G, BP 333, Bamako, Mali.
authors.forename: Daouda K
authors.initials: DK
authors.lastname: Minta
authors.forename: Mamadou
authors.initials: M
authors.lastname: Dembélé
authors.forename: Gilbert
authors.initials: G
authors.lastname: Lorre
authors.forename: Dapa A
authors.initials: DA
authors.lastname: Diallo
authors.forename: Hamar A
authors.initials: HA
authors.lastname: Traoré
authors.forename: Dominique
authors.initials: D
authors.lastname: Chabasse
mesh_terms: D000328:Adult; D006658:Histoplasma / Q000145:classification; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D008206:Lymphatic Diseases / Q000382:microbiology; D008297:Male; D008302:Mali; D010538:Peritonitis / Q000382:microbiology; D013369:Subphrenic Abscess / Q000382:microbiology