title: Transient receptor potential channels in the inner ear: presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear.
abstract: CONCLUSIONS
  The results of this study indicate that transient receptor potential subfamily 1 (TRPV1) may play a functional role in sensory cell physiology and that TRPV4 may be important for fluid homeostasis in the inner ear.
  
  
  OBJECTIVE
  To analyze the expression of TRPV1 and -4 in the normal guinea pig inner ear.
  
  
  METHODS
  Albino guinea pigs were used. The location of TRPV1 and -4 in the inner ear, i.e. cochlea, vestibular end organs and endolymphatic sac, was investigated by means of immunohistochemistry.
  
  
  RESULTS
  Immunohistochemistry revealed the presence of TRPV1 in the hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells of the vestibular end organs and vestibular ganglion cells. TRPV4 was found in the hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, sensory cells, transitional cells, dark cells in the vestibular end organs, vestibular ganglion cells and epithelial cells of the endolymphatic sac.
authors.affiliation: Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan. masati@ipc.hiroshima-u.ac.jp
authors.forename: Masaya
authors.initials: M
authors.lastname: Takumida
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kubo
authors.forename: Makiko
authors.initials: M
authors.lastname: Ohtani
authors.forename: Yuko
authors.initials: Y
authors.lastname: Suzuka
authors.forename: Matti
authors.initials: M
authors.lastname: Anniko
mesh_terms: D000818:Animals; D007758:Ear, Inner / Q000737:chemistry*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000737:chemistry; D007150:Immunohistochemistry; D009925:Organ of Corti / Q000737:chemistry; D013316:Stria Vascularis / Q000737:chemistry; D050051:Transient Receptor Potential Channels / Q000032:analysis*
chemical_list: D050051:Transient Receptor Potential Channels