Intramandibular inflammatory myofibroblastic tumor--a true neoplasm or reactive lesion?
OBJECTIVE
Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion reported to arise in various organs and by convention believed to be a nonneoplastic reactive inflammatory condition. Because of its radiographic and histologic similarities to malignancy, IMT can pose a considerable diagnostic dilemma. The purpose of this study is to report the first intramandibular IMT and to discuss the possible nature of this lesion.


METHODS
Detailed documentation of clinical, radiographic, and histologic features; literature review.


RESULTS
This lesion showed distinct radiographic, histologic, and immunohistochemical features. The lesion recurred 14 months after initial removal with almost identical histology.


CONCLUSIONS
This is the first documented case of an intramandibular IMT. Due to the rarity of these lesions, their clinical sequelae and prognosis are undetermined. As a result of specific immunohistochemical phenotyping and clinical behavior of this lesion, we favored a diagnosis of inflammatory myofibroblastic tumor. Wide excision with a long-term clinical follow-up is required.
Poh
Catherine F
CF
Oral Medicine Oral Pathology, University of British Columbia Faculty of Dentistry, Vancouver, Canada.
Priddy
Robert W
RW
Dahlman
Darren M
DM
D000199:Actins / Q000032:analysis; D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D047708:Myofibroma / Q000000981:diagnostic imaging / Q000473:pathology*; D009379:Neoplasms, Muscle Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D014746:Vimentin / Q000032:analysis
D000199:Actins; D014746:Vimentin; D000469:Alkaline Phosphatase