Ten novel HLA-DRB1 alleles and one novel DRB3 allele.
Ten novel HLA-DRB1 and one DRB3 alleles are described. Eight of the variants are single-nucleotide substitutions, four resulting in an amino acid change (DRB1*1145, *1148, *0828 and *1514) and four with silent substitutions (DRB1*040504, *130103, *160502 and DRB3*020204). Two alleles differ by two nucleotide changes altering one (DRB1*1447 and *1361) amino acid and one allele alters three nucleotides and two amino acids.
Lazaro
A M
AM
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Steiner
N K
NK
Moraes
M E
ME
Moraes
J R
JR
Ng
J
J
Hartzman
R J
RJ
Hurley
C K
CK
D019943:Amino Acid Substitution / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D006801:Humans; D009154:Mutation
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains