title: Compensatory lung growth in autologous lobar implant after pneumonectomy in dogs.
abstract: OBJECTIVE
  Evaluate compensatory lung growth (CLG) in lobar transplant and see if it is similar to CLG after lobectomy.
  
  
  METHODS
  We used 48 dogs in three groups (G1=control, G2=left cranial lobectomy, and G3=pneumonectomy with reimplantation of left caudal lobe). Five months after surgery animals underwent lung scintigraphy and were then sacrificed for lung morphometric study.
  
  
  RESULTS
  There was no correlation between scintigraphy and lung mass or lung volume. There was both mass and residual volume CLG in the operated groups, both contralateral and epsilateral to surgery; there was no compensation for total lung capacity or compliance in the remaining caudal lobe (G2) or the reimplanted caudal lobe (G3) 5 months after surgery, there was more damage in the reimplanted lobe. As previous studies have show that CLG starts with increased mass and residual volume and that compliance is later compensated, this study seems to have documented the beginning of CLG, with lung compliance being the limiting factor of CLG after 5 months of study.
  
  
  CONCLUSIONS
  There is CLG in both reimplanted lobe and contralateral lung but compliance is still reduced. CLG was similar in both groups but implanted lobe compliance was more prejudiced.
authors.affiliation: Thoracic Surgery Division, Department of Surgery and Orthopedics, School of Medicine (FMB), São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. acataneo@fmb.unesp.br
authors.forename: Antônio José Maria
authors.initials: AJ
authors.lastname: Cataneo
authors.forename: Daniele Cristina
authors.initials: DC
authors.lastname: Cataneo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016022:Case-Control Studies; D004195:Disease Models, Animal; D004285:Dogs; D008168:Lung / Q000000981:diagnostic imaging / Q000254:growth & development*; D008170:Lung Compliance / Q000502:physiology; D016040:Lung Transplantation; D008297:Male; D011013:Pneumonectomy; D011877:Radionuclide Imaging; D014109:Total Lung Capacity; D014182:Transplantation, Autologous