Neuropeptide Y suppresses glucose utilization in the dorsal optic tectum towards visual stimulation in the toad Bombina orientalis: a [14C]2DG study.
Neuropeptide Y (NPY) experimentally administered to the surface of the optic tectum in visually stimulated fire bellied toads diminishes local glucose utilization in the retinorecipient tectal laminae. Strong NPY-induced suppression of tectal glucose utilization was found even when visual retinal input to the tectum was boosted pharmacologically under systemic apomorphine treatment. These novel results on the local cerebral energy metabolism contribute to the concept that NPY controls retinotectal visual processing via an inhibitory mechanism.
Funke
Simone
S
Department of Neurobiology, Faculty of Natural Sciences, University of Kassel, Germany.
Ewert
Jörg-Peter
JP
D000818:Animals; D001001:Anura; D001058:Apomorphine / Q000494:pharmacology; D001345:Autoradiography / Q000379:methods; D002247:Carbon Isotopes / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D018491:Dopamine Agonists / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D009478:Neuropeptide Y / Q000494:pharmacology*; D010775:Photic Stimulation / Q000379:methods; D013477:Superior Colliculi / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects
D002247:Carbon Isotopes; D018491:Dopamine Agonists; D009478:Neuropeptide Y; D003847:Deoxyglucose; D005947:Glucose; D001058:Apomorphine