title: Urinary D-arabinitol/L-arabinitol levels in infants undergoing long-term antibiotic therapy.
abstract: Long-term antibiotic therapy is one of the main risk factors for mycosis. The urinary D-arabinitol/L-arabinitol (D-/L-ARA) ratio (a biomarker of several Candida species) was determined by gas chromatography with an electron capture detector in samples from 51 infants undergoing long-term antibiotic therapy. Although 47 of these children had higher D-/L-ARA ratios than healthy controls (P<0.0003), their values nonetheless remained within upper-normal limits (D-/L-ARA ratio of <3.6). Four children with suspected invasive candidiasis had above-normal ratios that normalized with fluconazole treatment.
authors.affiliation: Department of Laboratory Diagnostics, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-736 Warsaw, Poland. jstradomska@op.pl
authors.forename: Teresa J
authors.initials: TJ
authors.lastname: Stradomska
authors.forename: Bogumila
authors.initials: B
authors.lastname: Bobula-Milewska
authors.forename: Anna
authors.initials: A
authors.lastname: Bauer
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Mielniczuk
authors.forename: Maria
authors.initials: M
authors.lastname: Dabkowska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Syczewska
authors.forename: Danuta
authors.initials: D
authors.lastname: Dzierzanowska
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002177:Candidiasis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013402:Sugar Alcohols / Q000652:urine*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D013402:Sugar Alcohols; C014999:arabitol