Severe hypothyroidism due to atrophic thyroiditis from second year of life influenced developmental outcome.
From the second year of life a girl showed an insidious development of clinical hypothyroidism due to a non-goitrous lymphocytic thyroiditis without traceable circulating levels of thyroid antibodies measured by routine immunoassays. The diagnostic delay of this rare variant of atrophic thyroiditis caused persistent neuropsychological deficits.


CONCLUSIONS
Her difficulties with speed of processing and working memory in particular could suggest a frontal deficit, possibly in the dorsolateral prefrontal circuit. This contrasts with findings in congenital hypothyroidism, suggesting a relatively preserved frontal function, and could illustrate different neuropsychological deficits of hypothyroidism at different ages in early childhood.
Joergensen
J V
JV
Department of Paediatric Research, Rikshospitalet University Hospital, Oslo, Norway.
Oerbeck
B
B
Jebsen
P
P
Heyerdahl
S
S
Kase
B F
BF
D001284:Atrophy / Q000473:pathology; D001707:Biopsy, Needle; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D007150:Immunohistochemistry; D018570:Risk Assessment; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000473:pathology; D013974:Thyroxine / Q000008:administration & dosage*; D016896:Treatment Outcome
D013974:Thyroxine