title: Management of subconjunctival haematoma by tissue plasminogen activator.
abstract: A patient with subconjunctival haematoma related to enterovirus 70 who was treated with tissue plasminogen activator (tPA) is reported. A 46-year-old man developed a severe subconjunctival haematoma and discharge in the left eye. Investigations, including coagulation tests, showed no abnormalities apart from a high-serum antibody titre for enterovirus 70. The polymerase chain reaction demonstrated enterovirus 70 DNA in resected conjunctival tissue, leading to a diagnosis of acute haemorrhagic conjunctivitis. The left eye was treated with a single subconjunctival injection of tPA (16 000 IU) and the subconjunctival haematoma resolved completely after 3 days. Severe subconjunctival haematoma can occur in patients with acute haemorrhagic conjunctivitis due to enterovirus 70. Subconjunctival injection of tPA may be useful for the treatment of severe subconjunctival haematoma.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamagami
authors.forename: Hideharu
authors.initials: H
authors.lastname: Funatsu
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Usui
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ono
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Shiro
authors.initials: S
authors.lastname: Amano
mesh_terms: D003232:Conjunctivitis, Acute Hemorrhagic / Q000188:drug therapy* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D030016:Enterovirus D, Human / Q000235:genetics / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology; D015828:Eye Infections, Viral / Q000188:drug therapy* / Q000821:virology; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006406:Hematoma / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D004279:DNA, Viral; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator