title: Pyoderma gangrenosum associated with hidradenitis suppurativa.
abstract: Pyoderma gangrenosum (PG) is associated with a number of systemic diseases. PG in association with hidradenitis suppurativa (HS) has been rarely reported. We describe six patients (three men, three women; aged 35--51 years), who developed PG on a background of HS. The onset of PG occurred only after HS had been present for at least two decades. No relationship in disease activity between the two conditions was observed. Three patients described previous severe adolescent acne vulgaris, one had concurrent systemic lupus erythematosus and another had chronic iron-deficiency anaemia. The course of PG was severe and refractory in four patients, who required treatment including high-dose oral corticosteroids, ciclosporin, intravenous immunoglobulin and intravenous cyclophosphamide.
authors.affiliation: Department of Dermatology, Monklands Hospital, Lanarkshire and Sunderland Royal Hospital, Sunderland, UK. allanahweng@yahoo.co.uk
authors.forename: A
authors.initials: A
authors.lastname: Ah-Weng
authors.forename: J A A
authors.initials: JA
authors.lastname: Langtry
authors.forename: S
authors.initials: S
authors.lastname: Velangi
authors.forename: C D
authors.initials: CD
authors.lastname: Evans
authors.forename: W S
authors.initials: WS
authors.lastname: Douglas
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D017497:Hidradenitis Suppurativa / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide