[Ouabain: from an arrow poison to a new steroidal hormone].
For more than 200 years, cardiotonic glycosides have been used for the treatment of congestive heart failure. Ouabain is a well-known arrow poison obtained from different Acokanthera or Strophanthus species. Much information has now accumulated that this plant toxin and its congeners are mammalian steroid hormones involved in the pathophysiology of cardiovascular diseases. There is an interesting fact that 50% patients with essential hypertension have elevated levels of endogenous ouabain. A better knowledge of the interactions of these compounds with the hormones of salt and water metabolism might help to improve the diagnosis and therapy of hypertension.
Mucaji
P
P
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmakognózie a botaniky, SR. mucaji@fpharm.uniba.sk
Nagy
M
M
Grancai
D
D
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology / Q000627:therapeutic use*; D006728:Hormones / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D010042:Ouabain / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D013256:Steroids / Q000494:pharmacology / Q000502:physiology; D030013:Strophanthus
D002301:Cardiac Glycosides; D006728:Hormones; D010936:Plant Extracts; D013256:Steroids; D010042:Ouabain