title: Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin.
abstract: Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
authors.affiliation: Department of Basic Science, Yonsei University, Womju, Korea. sjlee@kd.ac.kr
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
authors.forename: Sangtae
authors.initials: S
authors.lastname: Oh
authors.forename: Gab-Man
authors.initials: GM
authors.lastname: Park
authors.forename: Tong-Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Jae-Sook
authors.initials: JS
authors.lastname: Ryu
authors.forename: Han-Kyu
authors.initials: HK
authors.lastname: Choi
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000737:chemistry / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D002738:Chloroquine