[Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia].
Electron microscopy and electrophysiological data reveal pronounced structural and functional disturbances in cerebral cortex of rats with model brain ischemia. A 5-day treatment with a dry extract from Rhaponticum carthamoides (Willd.) Iljin. in a daily dose of 150 mg/kg (p.o.) equivalent to 2.7 mg ecdysterone per kg body weight reduced manifestations of the ischemic damage, improved the structure of neurons, and restored brain activity (EEG parameters).
Plotnikov
M B
MB
Logvinov
S V
SV
Pugachenko
N V
NV
Maslov
M Iu
MIu
Aliev
O I
OI
Vasil'ev
A S
AS
Suslov
N I
NI
Potapov
A V
AV
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000503:physiopathology* / Q000648:ultrastructure; D005260:Female; D043843:Leuzea / Q000737:chemistry; D008297:Male; D009474:Neurons / Q000648:ultrastructure; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects*
D010936:Plant Extracts