[Non-hemodynamic effects of calcium channel blocker nifedipine: effects on functional activity of blood cells and endothelium].
OBJECTIVE
To compare efficacy of long-acting nifedipin (cordipin-XL) and beta-blocker atenolol (tenormin) in hypertensive patients; to assess efficacy of antihypertensive treatment on functional activity of blood and endothelial cells, remodeling of the myocardium and vessels.


METHODS
A total of 35 patients with essential hypertension stage II entered the trial. Eighteen of them received cordipin-XL, 17--tenormin.


RESULTS
Contrary to tenormin, cordipin-XL significantly improved blood rheology, reduced functional activity of leukocytes, concentration of Willebrand factor and intercellular adhesive molecules in blood plasm. Positive hemodynamic and non-hemodynamic effects of cordipin-XL were accompanied with reversion of left ventricular hypertrophy.


CONCLUSIONS
Non-hemodynamic effects of cordipin-XL associated with improvement of endothelial function and blood rheological properties seem to have an independent role in prophylaxis of cardiovascular complications.
Moiseeva
O M
OM
Villeval'de
S V
SV
Emel'ianov
I V
IV
Shliakhto
E V
EV
D015703:Antigens, CD / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects*; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D014841:von Willebrand Factor / Q000187:drug effects*
D015703:Antigens, CD; D002121:Calcium Channel Blockers; D014841:von Willebrand Factor; D018799:Intercellular Adhesion Molecule-1; D009543:Nifedipine