title: Direct autoradiographic evidence that rebamipide interacts with neutrophils in dextran sulfate sodium induced colitis in rats.
abstract: To determine the effects of rebamipide during the early stages of colitits development, colitis was induced in rats by oral administration of dextran sulfate sodium for 3 or 7 days. The target sites of (3)H-rebamipide were examined by intra-aortic infusion of the radiolabeled compound followed by autoradiography. (3)H-rebamipide was localized in goblet cells in the colon of the control rat, whereas it accumulated in the cytoplasm of mesenchymal cells in dextran sulfate sodium treated rats, localized predominantly to polymorphonuclear leucocytes.
authors.affiliation: Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. nakamuram@pharm.kitasato-u.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Koichiro
authors.initials: K
authors.lastname: Atsuda
authors.forename: Norifumi
authors.initials: N
authors.lastname: Hibi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Matsui
authors.forename: Haruki
authors.initials: H
authors.lastname: Yamada
authors.forename: Kanji
authors.initials: K
authors.lastname: Tsuchimoto
mesh_terms: D000284:Administration, Oral; D000409:Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D003092:Colitis / Q000503:physiopathology* / Q000517:prevention & control*; D016264:Dextran Sulfate / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D020397:Goblet Cells / Q000737:chemistry; D007202:Indicators and Reagents / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D009504:Neutrophils / Q000737:chemistry; D015363:Quinolones / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000897:Anti-Ulcer Agents; D007202:Indicators and Reagents; D015363:Quinolones; D016264:Dextran Sulfate; C052785:rebamipide; D000409:Alanine