Urinary D-arabinitol/L-arabinitol levels in infants undergoing long-term antibiotic therapy.
Long-term antibiotic therapy is one of the main risk factors for mycosis. The urinary D-arabinitol/L-arabinitol (D-/L-ARA) ratio (a biomarker of several Candida species) was determined by gas chromatography with an electron capture detector in samples from 51 infants undergoing long-term antibiotic therapy. Although 47 of these children had higher D-/L-ARA ratios than healthy controls (P<0.0003), their values nonetheless remained within upper-normal limits (D-/L-ARA ratio of <3.6). Four children with suspected invasive candidiasis had above-normal ratios that normalized with fluconazole treatment.
Stradomska
Teresa J
TJ
Department of Laboratory Diagnostics, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-736 Warsaw, Poland. jstradomska@op.pl
Bobula-Milewska
Bogumila
B
Bauer
Anna
A
Mielniczuk
Zbigniew
Z
Dabkowska
Maria
M
Syczewska
Malgorzata
M
Dzierzanowska
Danuta
D
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002177:Candidiasis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013402:Sugar Alcohols / Q000652:urine*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D013402:Sugar Alcohols; C014999:arabitol