Epstein-Barr virus related opsoclonus-myoclonus-ataxia does not rule out the presence of occult neuroblastic tumors.
Opsoclonus-myoclonus-ataxia (OMA) secondary to Epstein-Barr virus (EBV) infection has only been described in three pediatric patients. Previous reports suggested that evidence for a recent EBV infection in the absence of an occult neoplasm would predict a favorable prognosis for OMA as well as no tumor development. We present the case of a 20-month-old child with OMA associated with a microbiologically documented acute EBV infection and an occult thoracic ganglioneuroblastoma diagnosed 5 months later.
Cardesa-Salzmann
Teresa M
TM
Department of Pediatrics, Unitat Integrada Hospital Sant Joan de Déu-Hospital Clínic. University of Barcelona, Barcelona, Spain.
Mora
Jaume
J
García Cazorla
M Angels
MA
Cruz
Ofelia
O
Muñoz
Carmen
C
Campistol
Jaume
J
D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D018305:Ganglioneuroblastoma / Q000150:complications*; D006801:Humans; D007223:Infant; D053578:Opsoclonus-Myoclonus Syndrome / Q000209:etiology*; D013899:Thoracic Neoplasms / Q000150:complications*