Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma.
BACKGROUND
Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS.


METHODS
MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and cerebrospinal fluid (CSF) in subjects either interrupting (TI) or starting (TS) antiretroviral therapy.


RESULTS
Following TI, plasma VL rebounded first, followed by increases in CSF MCP-1, which immediately preceded or coincided with a rebound of CSF VL.


CONCLUSIONS
The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other.
Monteiro de Almeida
Sergio
S
HIV Neurobehavioral Research Center, UCSD, 150 West Washington St., 2nd Flr., San Diego, CA 92103, USA.
Letendre
Scott
S
Zimmerman
Joshua
J
Lazzaretto
Deborah
D
McCutchan
Allen
A
Ellis
Ronald
R
D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D018932:Chemokine CCL2 / Q000097:blood* / Q000134:cerebrospinal fluid*; D003072:Cognition Disorders / Q000209:etiology / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D013997:Time Factors; D019562:Viral Load / Q000379:methods
D044966:Anti-Retroviral Agents; D018932:Chemokine CCL2; D012367:RNA, Viral