[Comparative study of the biocompatibility of the porcine intestinal submucosa and bovine pericardium used as grafts in the inferior cava vein of dogs].
OBJECTIVE
To compare the biocompatibility of the bovine pericardium and the small intestine submucosa (SIS) when used to repair a created defect in the inferior vena cava of dogs.


METHODS
Sixteen male mongrel dogs were submitted to a midline laparotomy incision. An elliptical segment (1.5 x 3.0 cm) of the inferior vena cava, below the renal veins, was excised. In 8 dogs, the A group, a patch of porcine small bowel submucosa was used to repair the defect. In the 8 remaining dogs, the B group, a bovine pericardium was implanted in the vena cava. On the 30th post-operative day an ultrasound was performed in order to identify stenosis. The euthanasia was accomplished in the 40th post-operative day. Stenosis of the vein was observed in 1 dog of A group and in 2 of the B group.


RESULTS
Partial thrombosis with collateral circulation was evidenced in 1 dog of the bovine pericardium group. A moderated chronic inflammatory process was evidenced in both groups. Microscopic evaluation, regarding endothelization of the implant, collagen deposition, smooth muscle growth, was similar in both groups.


CONCLUSIONS
SIS proved to be a functional graft patch for possessing local vena cava remodeling and its biocompatibility was similar to bovine pericardium.
Greca
Fernando Hintz
FH
Faculdade de Medicina, Pontifícia Universidade do Paraná. fernando.greca@bbs2.sul.com.br
Noronha
Lucia de
Ld
Costa
Francisco Diniz Afonso da
FD
Souza Filho
Zacarias Alves de
ZA
Soccol
Andréa Thomaz
AT
Feres
André Néry
AN
Duda
Jõao Ricardo
JR
Adams
Eduardo
E
D000818:Animals; D001807:Blood Vessel Prosthesis; D002417:Cattle; D004285:Dogs; D006648:Histocompatibility; D007413:Intestinal Mucosa / Q000637:transplantation*; D007421:Intestine, Small; D008297:Male; D010496:Pericardium / Q000637:transplantation*; D013552:Swine; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology / Q000601:surgery*