Cicatricial pemphigoid of the oropharynx after allogeneic stem cell transplantation for relapsed follicular lymphoma.
A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial pemphigoid (CP) was made, and complete resolution of the CP was achieved with prednisolone therapy. The occurrence of autoimmune blistering diseases is rare after allogeneic SCT.
Aisa
Yoshinobu
Y
Division of Hematology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan. yaisa@sc.itc.keio.ac.jp
Mori
Takehiko
T
Nakazato
Tomonori
T
Yamazaki
Rie
R
Yamagami
Jun
J
Amagai
Masayuki
M
Ikeda
Yasuo
Y
Okamoto
Shinichiro
S
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008224:Lymphoma, Follicular / Q000150:complications / Q000473:pathology* / Q000628:therapy; D009055:Mouth / Q000473:pathology*; D009960:Oropharynx / Q000473:pathology*; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011239:Prednisolone