Two-stage enzyme mediated drug release from LMWG hydrogels.
An enzymatically cleavable low molecular weight gelator-(model) drug conjugate system can be employed to effect a two-step enzyme mediated drug release, demonstrating the potential of LMWG systems for the development of drug delivery devices.
van Bommel
Kjeld J C
KJ
Biomade Technology Foundation, Nijenborgh 4, 9747 AG, Groningen, The Netherlands. van.bommel@biomade.nl
Stuart
Marc C A
MC
Feringa
Ben L
BL
van Esch
Jan
J
D002918:Chymotrypsin; D016503:Drug Delivery Systems; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008970:Molecular Weight
D020100:Hydrogels; D002918:Chymotrypsin; C117608:alpha-chymotrypsin