Measles virus infection induces interleukin-8 release in human pulmonary epithelial cells.
Measles virus (MV) infection primarily targets epithelial cells of the respiratory tract, which have the potential to synthesize a variety of cytokines. In this report, we studied the effect of MV infection on the production of interleukin (IL)-8 by the pulmonary epithelial cells. A549 cells, a lower airway epithelial cell line, produced IL-8 after MV inoculation in a dose- and time-dependent manner. The IL-8 production was little affected by UV-inactivation of MV and scarcely suppressed by cycloheximide treatment. These results indicated that MV particle binding to and/or incorporation into cells stimulated IL-8 expression in A549 cells.
Sato
Hiroki
H
Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Miura
Ryuichi
R
Kai
Chieko
C
D000818:Animals; D045744:Cell Line, Tumor; D003513:Cycloheximide / Q000494:pharmacology; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism / Q000821:virology; D016209:Interleukin-8 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D008168:Lung / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D008457:Measles / Q000276:immunology* / Q000821:virology; D008459:Measles virus / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D014779:Virus Replication / Q000276:immunology
D016209:Interleukin-8; D011500:Protein Synthesis Inhibitors; D012333:RNA, Messenger; D003513:Cycloheximide