Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1.
A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and 2 cell-based functional assays. Indole-O-glucoside 10a and benzimidazole-O-glucoside 18 exhibited potent in vitro SGLT2 inhibitory activity.
Zhang
Xiaoyan
X
Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA. xzhang11@prdus.jnj.com
Urbanski
Maud
M
Patel
Mona
M
Zeck
Roxanne E
RE
Cox
Geoffrey G
GG
Bian
Haiyan
H
Conway
Bruce R
BR
Pat Beavers
Mary
M
Rybczynski
Philip J
PJ
Demarest
Keith T
KT
D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D000077203:Sodium-Glucose Transporter 2 Inhibitors
D005960:Glucosides; D000077203:Sodium-Glucose Transporter 2 Inhibitors