Family aggregation of upper airway soft tissue structures in normal subjects and patients with sleep apnea.
BACKGROUND
Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation.


OBJECTIVE
We used volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation of the size of upper airway soft tissue structures that are associated with increased risk for obstructive sleep apnea.


METHODS
We examined 55 sleep apnea probands (apnea-hypopnea index [AHI]: 43.2 +/- 26.3 events/h), 55 proband siblings (AHI: 11.8 +/- 16.6 events/h), 55 control subjects (AHI: 2.1 +/- 1.7 events/h), and 55 control siblings (AHI: 4.2 +/- 4.0 events/h). The study design used exact matching on ethnicity and sex, frequency matching on age, and statistical control for visceral neck fat and craniofacial dimensions.


RESULTS
The data support our a priori hypothesis that the volume of the important upper airway soft tissue structures is heritable. The volume of the lateral pharyngeal walls (h(2) = 36.8%; p = 0.001), tongue (h(2) = 36.5%; p = 0.0001), and total soft tissue (h(2) = 37.5%; p = 0.0001) demonstrated significant levels of heritability after adjusting for sex, ethnicity, age, visceral neck fat, and craniofacial dimensions. In addition, our data indicate that heritability of the upper airway soft tissue structures is found in normal subjects and patients with apnea. Thus, it is not simply a consequence of the prevalence of apnea.


CONCLUSIONS
This is the first time family aggregation of size of the upper airway soft tissue structures has been demonstrated.
Schwab
Richard J
RJ
Center for Sleep and Respiratory Neurobiology, 893 Maloney Building, University of Pennsylvania Medical Center, 3600 Spruce Street, Philadelphia, PA 19104-4283, USA. rschwab@mail.med.upenn.edu
Pasirstein
Michael
M
Kaplan
Laura
L
Pierson
Robert
R
Mackley
Adonna
A
Hachadoorian
Robert
R
Arens
Raanan
R
Maislin
Greg
G
Pack
Allan I
AI
D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010160:Palate, Soft / Q000473:pathology*; D010614:Pharynx / Q000473:pathology*; D012891:Sleep Apnea Syndromes / Q000235:genetics* / Q000473:pathology*; D014059:Tongue / Q000473:pathology*