On the road to cancer: aneuploidy and the mitotic checkpoint.
Abnormal chromosome content - also known as aneuploidy - is the most common characteristic of human solid tumours. It has therefore been proposed that aneuploidy contributes to, or even drives, tumour development. The mitotic checkpoint guards against chromosome mis-segregation by delaying cell-cycle progression through mitosis until all chromosomes have successfully made spindle-microtubule attachments. Defects in the mitotic checkpoint generate aneuploidy and might facilitate tumorigenesis, but more severe disabling of checkpoint signalling is a possible anticancer strategy.
Kops
Geert J P L
GJ
Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center, Utrecht, 3584 CG, The Netherlands. g.j.p.l.kops@med.uu.nl
Weaver
Beth A A
BA
Cleveland
Don W
DW
D000782:Aneuploidy; D043171:Chromosomal Instability; D016147:Genes, Tumor Suppressor; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction