YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.
The first genetic, in vivo, and in vitro evidences that YrxA is the regulator of NAD de novo biosynthesis in Bacillus subtilis are hereby reported. The protein is essential to the transcription repression of the divergent operons nadBCA and nifS-yrxA in the presence of nicotinic acid and binds to their shared operator-promoter region.
Rossolillo
Paola
P
Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, 1, Via Ferrata, 27100 Pavia, Italy.
Marinoni
Ilaria
I
Galli
Elisa
E
Colosimo
Anna
A
Albertini
Alessandra M
AM
D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000502:physiology*; D016680:Genome, Bacterial; D009154:Mutation; D009243:NAD / Q000096:biosynthesis*; D009525:Niacin / Q000378:metabolism; D009876:Operon / Q000502:physiology; D010430:Pentosyltransferases / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D001426:Bacterial Proteins; C080001:nifS protein, Bacteria; D009243:NAD; D009525:Niacin; D010430:Pentosyltransferases; C021864:nicotinate phosphoribosyltransferase