title: YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.
abstract: The first genetic, in vivo, and in vitro evidences that YrxA is the regulator of NAD de novo biosynthesis in Bacillus subtilis are hereby reported. The protein is essential to the transcription repression of the divergent operons nadBCA and nifS-yrxA in the presence of nicotinic acid and binds to their shared operator-promoter region.
authors.affiliation: Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, 1, Via Ferrata, 27100 Pavia, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Rossolillo
authors.forename: Ilaria
authors.initials: I
authors.lastname: Marinoni
authors.forename: Elisa
authors.initials: E
authors.lastname: Galli
authors.forename: Anna
authors.initials: A
authors.lastname: Colosimo
authors.forename: Alessandra M
authors.initials: AM
authors.lastname: Albertini
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000502:physiology*; D016680:Genome, Bacterial; D009154:Mutation; D009243:NAD / Q000096:biosynthesis*; D009525:Niacin / Q000378:metabolism; D009876:Operon / Q000502:physiology; D010430:Pentosyltransferases / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; C080001:nifS protein, Bacteria; D009243:NAD; D009525:Niacin; D010430:Pentosyltransferases; C021864:nicotinate phosphoribosyltransferase