Donepezil restores GH secretion in old rats without affecting the sleep/wake cycle.
A chronic treatment with a cholinesterase inhibitor, donepezil (0.085 mg/kg/h for 30 days) increases significantly the number and amplitude of growth hormone (GH) pulses in 3- and 24-month-old rats without modifying nadir GH values. This treatment does not reduce age-related alterations in sleep/wake cycle but it increases immobility-related high-voltage spindles (HVS) in old animals. These data suggest that cholinergic mechanisms involved in age-related alterations in GH and sleep regulation are different.
Zizzari
P
P
UMR 549, INSERM-Université Paris 5 René Descartes, IFR Broca-Ste Anne, 2 ter rue d'Alésia, Paris 75014, France. zizzari@broca.inserm.fr
Bassant
M H
MH
Poindessous-Jazat
F
F
Epelbaum
J
J
Bluet-Pajot
M T
MT
D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000077265:Donepezil; D004569:Electroencephalography / Q000187:drug effects; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007189:Indans / Q000008:administration & dosage / Q000494:pharmacology*; D015918:Infusion Pumps, Implantable; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D007334:Insulin-Like Growth Factor I; D000077265:Donepezil; D013006:Growth Hormone; D000110:Acetylcholinesterase