The diagnosis of minimal change disease in diabetic nephropathy.
Proteinuria is common in diabetic patients and usually reflects the presence of diabetic glomerulosclerosis. This paper reviews the differential diagnosis of proteinuria in diabetic patients and discusses the role of renal biopsy examination in identification and management of minimal change disease in this cohort. Identification of nondiabetic glomerular disease requires careful correlation of clinical history and renal biopsy findings and may have important implications for prognosis and therapy.
Stokes
M Barry
MB
Department of Pathology, Renal Pathology Laboratory, VC14-224, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. mbs2101@columbia.edu
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003928:Diabetic Nephropathies / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D011507:Proteinuria / Q000175:diagnosis*