Volume increases in striatum associated with positive symptom reduction in schizophrenia: a preliminary observation.
Eleven drug-free patients with a DSM-IV diagnosis of schizophrenia who were in a period of psychotic exacerbation were treated with antipsychotics for 4 weeks. To evaluate treatment-associated changes in the basal ganglia and in psychotic symptomatology, the patients were studied with magnetic resonance imaging and with the Scale for the Assessment of Positive Symptoms. Serial assessments of striatal volumes and psychotic symptoms were performed at baseline and at 4 weeks of treatment; dual assessments of striatal volumes were also performed in 11 untreated normal controls. Patients and controls did not differ in striatal volumes at baseline, but the patients demonstrated a significant posttreatment increase in striatal tissues (caudate-putamen). An increase in left striatum was not associated with drug treatment itself, but with a reduction of positive symptoms.
Taylor
Stephen
S
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Medical Center 1, Suite 340, Louisville, KY 40202, USA. smtay103@gwise.louisville.edu
Christensen
James D
JD
Holcomb
Jennifer M
JM
Garver
David L
DL
D000328:Adult; D000339:Affect; D002421:Caudate Nucleus / Q000002:abnormalities / Q000503:physiopathology; D003342:Corpus Striatum / Q000002:abnormalities* / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D011618:Psychotic Disorders / Q000175:diagnosis / Q000503:physiopathology; D011699:Putamen / Q000002:abnormalities / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*