title: Cosegregation of bipolar disorder and autosomal-dominant medullary cystic kidney disease in a large family.
abstract: OBJECTIVE
  The authors report a large family in which bipolar disorder appears to cosegregate with autosomal-dominant medullary cystic kidney disease.
  
  
  METHODS
  Information regarding diagnostic criteria for bipolar disorder and medullary cystic kidney disease were gathered from family members through formal research interviews, hospital admission records, imaging reports, and laboratory data.
  
  
  RESULTS
  Of the seven members with medullary cystic kidney disease, five had bipolar I disorder, one had unipolar depression, and one had a hyperthymic phenotype. Information was not available on two members.
  
  
  CONCLUSIONS
  The cosegregation in this family suggests a close proximity between genes for the two disorders. The two known loci of medullary cystic kidney disease are in regions of chromosomes 1 and 16 that have been previously linked to bipolar disorder and schizophrenia. This family may be a useful resource for positional cloning of bipolar candidate genes.
authors.affiliation: Department of Psychiatry, 0603, University of California-San Diego, La Jolla, CA 92093-0603, USA.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Kimmel
authors.forename: Ildiko
authors.initials: I
authors.lastname: Kovacs
authors.forename: Cathy
authors.initials: C
authors.lastname: Vrabel
authors.forename: Barry
authors.initials: B
authors.lastname: Wood
authors.forename: Martin
authors.initials: M
authors.lastname: Schalling
authors.forename: John R
authors.initials: JR
authors.lastname: Kelsoe
mesh_terms: D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D015897:Comorbidity; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology / Q000235:genetics*
chemical_list: D005819:Genetic Markers