[Significance of MDM2 protein in the cell cycle].
The basis of oncogenesis underlies the modification of the control of the cell cycle, which leads to disturb balance between proliferation and apoptosis. The MDM2 protein suppresses the ability of p53 to activate genes responsible for repairing or apoptosis, but also promotes p53 degradation by ubiquitination. MDM2 inhibits tumor suppressor property of pRb, by releasing E2F1, which stimulates DNA synthesis in S-phase. MDM2 influences on the neuronal and muscle differentiation. Quantity and stability of the MDM2 protein is regulated by p73, p53, TSG101, p14ARF and Ras-Raf-MEK-ERK pathway. Changes of the level of the MDM2 can disturb control of cell cycle and contribute to oncogenesis.
Szemraj
Janusz
J
Department of Biochemistry, Institute of Physiology and Biochemistry, Medical University of Lodz, 6/8 Mazowiecka St., 92-215 Lodz, Poland.
Rozpończyk
Elzbieta
E
Bartkowiak
Jacek
J
Greger
Janusz
J
Oszajca
Katarzyna
K
D017209:Apoptosis; D002453:Cell Cycle / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D009857:Oncogenes; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D000072160:Tumor Protein p73; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins; D014452:Ubiquitins; D000099177:Tsg101 Protein
D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D009687:Nuclear Proteins; D051736:Proto-Oncogene Proteins c-mdm2; D014157:Transcription Factors; D000072160:Tumor Protein p73; D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D014452:Ubiquitins; D000099177:Tsg101 Protein; C000606460:TP73 protein, human; C497206:MDM2 protein, human