title: Carbon-carbon bond-forming enantioselective synthesis of chiral organosilicon compounds by rhodium/chiral diene-catalyzed asymmetric 1,4-addition reaction.
abstract: [reaction: see text] A new synthetic method for chiral organosilicon compounds through a rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to beta-silyl alpha,beta-unsaturated carbonyl compounds has been developed. By employing (R,R)-Bn-bod* as a ligand, a range of arylboronic acids can be coupled with these substrates in very high enantiomeric excess. The resulting beta-silyl 1,4-adducts can be converted to beta-hydroxy carbonyl compounds or allylsilanes while retaining their stereochemical information.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shintani
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okamoto
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi