Enhancing central nervous system remyelination in multiple sclerosis.
Recent studies on adult neural stem cells and the developmental biology of myelination have generated the expectation that neural precursors can repair the damaged central nervous system of multiple sclerosis patients where the endogenous remyelination process has failed. As a result, many laboratories are engaged in translational studies in which the goal is to design ways to promote remyelination and repair. Here we raise issues highlighted by prior experimental and human work that should be considered lest these studies become "lost in translation."
Dubois-Dalcq
Monique
M
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. dalcqm@mail.nih.gov
Ffrench-Constant
Charles
C
Franklin
Robin J M
RJ
D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D002490:Central Nervous System / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000628:therapy*; D009186:Myelin Sheath / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology; D012038:Regeneration