Evaluation of photochemical tissue bonding for closure of skin incisions and excisions.
OBJECTIVE
Photochemical tissue bonding (PTB) is a new non-thermal technique for tissue repair involving application of a photochemically active dye and irradiation with visible light. The objective was to compare PTB with standard sutures and the tissue adhesive, octyl cyanoacrylate, for closure of skin incisions and excisions.


METHODS
Incisions and excisions made on the flanks of a Hanford mini-pig were secured with subcutaneous sutures. Superficial closure methods were 3-0 monofilament sutures, PTB (Rose Bengal and green light), tissue adhesive and the combination of tissue adhesive then PTB. Wounds were evaluated 2, 4, and 6 weeks postoperatively for cosmetic outcomes and histology.


RESULTS
Cosmetic outcomes and histological scar width of incisions and excisions did not differ among the treatment groups at 2, 4, and 6 weeks.


CONCLUSIONS
PTB is as effective as standard sutures for wound closure in porcine skin in terms of cosmetic outcomes and safety.
Kamegaya
Yoko
Y
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Farinelli
William A
WA
Vila Echague
Agustina V
AV
Akita
Hirotaka
H
Gallagher
Jamie
J
Flotte
Thomas J
TJ
Anderson
R Rox
RR
Redmond
Robert W
RW
Kochevar
Irene E
IE
D000818:Animals; D062109:Dermatologic Surgical Procedures; D004954:Esthetics; D005456:Fluorescent Dyes / Q000008:administration & dosage*; D028022:Low-Level Light Therapy; D008297:Male; D010777:Photochemistry; D012395:Rose Bengal / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology; D013537:Sutures; D013552:Swine; D013556:Swine, Miniature; D014014:Tissue Adhesives; D014945:Wound Healing
D005456:Fluorescent Dyes; D014014:Tissue Adhesives; D012395:Rose Bengal