title: Effectiveness of herbal medicine (Rokumigan and Hachimijiogan) for fatigue or loss of energy in patients with partial remitted major depressive disorder.
abstract: Some patients with major depressive disorder (MDD) do not show remission of their depressive symptomatology. We investigated the efficacy of Rokumigan (TJ-87) and Hachimijiogan (TJ-7) in 20 patients with prolonged partial remitted MDD associated with fatigue or loss of energy. In these 20 patients, TJ-7 or TJ-87 was added to the previous regimen for 4 weeks. Six patients were 'much improved', six were 'minimally improved' (responders), and eight showed 'no change' (non-responders), on the Clinical Global Impression Global Improvement scale. All responders had Shofuku-fujin (tenderness or weakness of the lower abdomen). In conclusion, we experienced 12 outpatients with prolonged partial remitted MDD with fatigue or loss of energy, which was successfully treated with TJ-87 or TJ-7.
authors.affiliation: Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan. yamadaps@dnh.twmu.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Gohei
authors.initials: G
authors.lastname: Yagi
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D000328:Adult; D000368:Aged; D003865:Major Depressive Disorder / Q000150:complications* / Q000523:psychology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D004415:Dyspepsia / Q000139:chemically induced; D005221:Fatigue / Q000188:drug therapy* / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D018908:Muscle Weakness / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C054591:hachimijiogan; C507123:rokumigan