title: [Simulation of migration from a multi-layer laminated film intended for retort foods].
abstract: Migration from multi-layer laminated film pouches intended for retort foods was investigated through HPLC analysis with a fluorescence detector, and measurements of residue on evaporation, consumption of potassium permanganate and total organic carbon. HPLC analysis revealed that the levels of migrants in oil and the water which were heated in the pouches (121 degrees C, 30 min) were ten times of those in the corresponding official simulants under the official conditions; n-heptane (25 degrees C, 60 min), and water (95 degrees C, 30 min). Bisphenol A diglycidyl ether and related compounds were found in the oil and the water heated in the pouches, as well as in the simulants. These compounds were thought to have been present in the adhesive between the laminated films, and migrated through the food-contact film of the package. Consumption of potassium permanganate and residue on evaporation of the heated water were ten times of those of the water simulant, while the total organic carbon level of the heated water was several-hold greater than that of the water simulant. In addition, migrant levels per surface area of the pouch were one-fourth of the concentrations per content volume of the pouch. Since compliance with the legal limits is evaluated based on the concentration per surface area, real migration into foods would be underestimated by a factor of another four.
authors.affiliation: The Tokyo Metropolitan Institute of Public Healt, 3-24-1, Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Uematsu
authors.forename: Mami
authors.initials: M
authors.lastname: Ogimoto
authors.forename: Junichiro
authors.initials: J
authors.lastname: Kabashima
authors.forename: Kumi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Reiko
authors.initials: R
authors.lastname: Kaneko
authors.forename: Keiichi
authors.initials: K
authors.lastname: Funayama
authors.forename: Nahoko
authors.initials: N
authors.lastname: Haneishi
authors.forename: Tetsuko
authors.initials: T
authors.lastname: Yasuno
authors.forename: Shuzo
authors.initials: S
authors.lastname: Ogino
mesh_terms: D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004852:Epoxy Compounds / Q000032:analysis*; D005504:Food Analysis / Q000379:methods*; D018857:Food Packaging; D005519:Food Preservation; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds