[Study on the association among total immunoglobulin E and eosinophil in nasal polyp].
OBJECTIVE
To explore the expression of total immunoglobulin E(IgE) and eosinophil in nasal polyp and their roles in the pathogenesis of nasal polyp.


METHODS
Thirty eight patients with nasal polyp and 15 control cases were chosen. All samples were stained with Chromotrope 2R histochemical and SP immunohistochemical method separately to examine eosinophil and total IgE+ cells in nasal polyp.


RESULTS
(1) The level of total IgE and eosinophil in nasal polyp was all significantly higher than that in normal control specimens (P < 0.01). (2) The positive correlation of total IgE and eosinophil was significant (r = 0.843, P < 0.01).


CONCLUSIONS
Nasal polyp is a disease characterized by eosinophils infiltration. Type I allergic reaction mediated by IgE assemble and activate eosinophils which may play an important role in the infiltration pathogenesis of nasal polyp.
Zhu
Shenghua
S
Department of Otolaryngology, Shaoyang Central Hospital, Shaoyang, 422000, China. wuminman@sina.com
Luo
Xuemei
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism; D009298:Nasal Polyps / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D007073:Immunoglobulin E