[Analysis of Spanish scientific production in rare diseases: 1990-2000].
OBJECTIVE
To analyze the Spanish scientific production in a group of rare diseases selected during the period 1990-2000.


METHODS
Analysis of the following disease groups: congenital anomalies, metabolism inborn errors and primary immunodeficiencies. Bibliometric tools were used to assess and analyze the evolution of research in this area. The MEDLINE database was utilized for references search.


RESULTS
Total references recovered for the study were 2978: 82.5% original articles and 17.3% reviews. The number of authors was 14,752 and the mean author/article was 4.9%. Seven types of institutions were coded with hospitals being the most productive with 78% of articles published. The Bradford nucleus was formed by 1,288 articles and 43.2% of the total had been published in 12 journals (2.1%).


CONCLUSIONS
Despite rare diseases research is still scarce, important efforts have been made at a national level focused on the development and strengthening of research in this field. Nevertheless, it is necessary to join efforts in this field to facilitate an appropriate research policy making that may help improve the current status.
Escudero Gómez
Cristina
C
Biblioteca, Hospital Universitario Puerta de Hierro, Madrid, Spain. cescuderog.hpth@salud.madrid.org
Millán Santos
Isabel
I
Posada de la Paz
Manuel
M
D015706:Bibliometrics; D035843:Biomedical Research / Q000706:statistics & numerical data*; D011643:Publishing / Q000706:statistics & numerical data*; D035583:Rare Diseases; D013030:Spain