A role for RKIP in cell motility.
The target of locostatin, a small-molecule inhibitor of cell movement, has been identified as RKIP, a Raf-1 kinase modulator [1]. In addition to advancing our understanding of cell locomotion, this work represents a major landmark in the development of chemical genetics.
Bement
William M
WM
Department of Zoology, University of Wisconsin-Madison, 53708, USA.
D000727:Androgen-Binding Protein / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D019908:Proto-Oncogene Proteins c-raf / Q000037:antagonists & inhibitors
D000727:Androgen-Binding Protein; D019908:Proto-Oncogene Proteins c-raf