title: More than just an ocular solution.
abstract: Apraclonidine eye drop is an alpha adrenergic agonist derived topical clonidine, used for the treatment of intraocular pressure elevation. We report what is to our knowledge the first case of systemic toxicity of apraclonidine resulted from repeated local administration. Clinical manifestation of toxicity was similar to oral clonidine overdose. Toxicities of ocular drugs should always be considered when a patient presents with new systemic problems.
authors.affiliation: Department of Emergency Medicine, Kocaeli Universty, Kocaeli, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Pekdemir
authors.forename: S
authors.initials: S
authors.lastname: Yanturali
authors.forename: G
authors.initials: G
authors.lastname: Karakus
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D003244:Consciousness Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008875:Middle Aged; D009883:Ophthalmic Solutions
chemical_list: D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; C016986:apraclonidine; D003000:Clonidine