Probing the onset and regulation of erythroid cell-specific gene expression.
Cell-restricted transcriptional modulators play a crucial role in the process of selective gene regulation during hematopoiesis. Erythroid Kruppel-like factor (EKLF; KLF1) is a transcription factor, originally identified in this laboratory, which plays a crucial role as a transcriptional activator at the adult beta-globin locus. This review will describe a subset of experiments and approaches related to deciphering its mechanism of action and the means by which it itself is induced.
Bieker
James J
JJ
Mount Sinai School of Medicine, New York, NY 10029, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D041905:Erythroid Cells / Q000166:cytology / Q000378:metabolism*; D004920:Erythropoiesis / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D012333:RNA, Messenger / Q000235:genetics*; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors; C080774:erythroid Kruppel-like factor