[Verapamil-induced hyperprolactinemia--a case report].
In many cases hyperprolactinemia can be caused by taking medications. Occasionally, verapamil-treated patients experience a slight asymptomatic increase in serum prolactin level. In this article we report the case of 42-year woman with manifest verapamil-induced hyperprolactinemia whose clinical symptoms suggested the occurrence of prolactinoma. A marked increase in prolactin levels and the preserved reactivity of this hormone in dynamic tests suggested that the patient exhibited "hypersensitivity" to verapamil. In the described state of the examined female detection of the disease, verapamil withdrawal and temporary bromocriptine administration have led to a full normalization of patient's clinical status.
Krysiak
Robert
R
Katedra Farmakologii, Zakład Farmakologii Klinicznej SI. AM. r.krysiak@pharmanet.com.pl
Okopieh
Bogusław
B
Herman
Zbigniew Stanisław
ZS
D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced* / Q000188:drug therapy; D006727:Hormone Antagonists / Q000008:administration & dosage; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D011388:Prolactin / Q000097:blood; D013997:Time Factors; D014700:Verapamil / Q000009:adverse effects*
D002121:Calcium Channel Blockers; D006727:Hormone Antagonists; D001971:Bromocriptine; D011388:Prolactin; D014700:Verapamil