title: First successful treatment of Nocardia farcinica brain abscess with moxifloxacin.
abstract: Nocardia farcinica is an emerging pathogen in immunosuppressed patients causing both localized and disseminated infections. Many strains of this species are multidrug-resistant and require long-term antibiotic therapy, and consequently the choice of an oral treatment can be problematic. We report here the first case of successful treatment of N. farcinica brain abscess in a renal transplant recipient with an extended-spectrum fluoroquinolone, moxifloxacin.
authors.affiliation: Faculté de Médecine Lariboisière-Saint Louis, Université Paris 7, Paris, France. vincent.fihman@lrb.aphp.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Fihman
authors.forename: Béatrice
authors.initials: B
authors.lastname: Berçot
authors.forename: Joaquim
authors.initials: J
authors.lastname: Mateo
authors.forename: Marie-Reine
authors.initials: MR
authors.lastname: Losser
authors.forename: Laurent
authors.initials: L
authors.lastname: Raskine
authors.forename: Jacques
authors.initials: J
authors.lastname: Riahi
authors.forename: Philippe
authors.initials: P
authors.lastname: Loirat
authors.forename: Marie-José Sanson-Le
authors.initials: MJ
authors.lastname: Pors
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001372:Aza Compounds / Q000627:therapeutic use*; D001707:Biopsy, Needle; D001922:Brain Abscess / Q000188:drug therapy*; D024841:Fluoroquinolones; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000276:immunology*; D008169:Lung Abscess / Q000473:pathology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000077266:Moxifloxacin; D009615:Nocardia / Q000302:isolation & purification; D009617:Nocardia Infections / Q000188:drug therapy*; D011804:Quinolines / Q000627:therapeutic use*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D007166:Immunosuppressive Agents; D011804:Quinolines; D012336:RNA, Ribosomal, 16S; D000077266:Moxifloxacin