Loss of insight and functional neuroimaging in frontotemporal dementia.
Loss of insight is a diagnostic criterion for frontotemporal dementia. It is associated with hypoperfusion/hypometabolism in the right hemisphere, particularly the frontal lobe. Loss of insight is often an anosodiaphoria (i.e., lack of concern) rather than an anosognosia (i.e., decreased awareness).
Mendez
Mario F
MF
Neurobehavior Unit (116AF), VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. mmendez@UCLA.edu
Shapira
Jill S
JS
D000368:Aged; D000704:Analysis of Variance; D003704:Dementia / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012920:Social Behavior Disorders / Q000473:pathology* / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon