title: Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events.
abstract: The effect of breathing 0.1 minimum alveolar concentrations (MAC) of desflurane or isoflurane for three minutes on the incidence of adverse airway events on a subsequent breath of 2 MAC was investigated. Twenty-five volunteers known to develop an adverse airway event to desflurane or isoflurane took part in the study. Each volunteer was exposed to isoflurane and desflurane at least 24 h apart. Volunteers were assessed for adverse airway events while breathing 2 MAC inhalational anaesthetic following breathing 100% O(2) for 3 min. This was repeated with 0.1 MAC inhalational anaesthetic in oxygen instead of 100% O(2). Adverse airway events decreased from 88% to 40% when tests were conducted with desflurane (p = 0.002). With isoflurane, the reduction from 60% to 52% was not statistically significant (p = 0.774). Breathing low concentrations of desflurane decreases the incidence of adverse airway events on subsequent inhalation of higher concentration of desflurane.
authors.affiliation: University Hospital of Wales, Heath Park, Cardiff CF14 4XN, Wales, UK.
authors.forename: N
authors.initials: N
authors.lastname: Goodwin
authors.forename: P J
authors.initials: PJ
authors.lastname: Strong
authors.forename: G
authors.initials: G
authors.lastname: Sudhir
authors.forename: A R
authors.initials: AR
authors.lastname: Wilkes
authors.forename: J E
authors.initials: JE
authors.lastname: Hall
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D003371:Cough / Q000139:chemically induced; D018592:Cross-Over Studies; D000077335:Desflurane; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced*; D007530:Isoflurane / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008297:Male; D012120:Respiration Disorders / Q000139:chemically induced; D012472:Salivation / Q000187:drug effects; D016037:Single-Blind Method
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane