title: Free modeling with Rosetta in CASP6.
abstract: We describe Rosetta predictions in the Sixth Community-Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction (CASP), focusing on the free modeling category. Methods developed since CASP5 are described, and their application to selected targets is discussed. Highlights include improved performance on larger proteins (100-200 residues) and the prediction of a 70-residue alpha-beta protein to near-atomic resolution.
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Philip
authors.initials: P
authors.lastname: Bradley
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Lars
authors.initials: L
authors.lastname: Malmström
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Bin
authors.initials: B
authors.lastname: Qian
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Jack
authors.initials: J
authors.lastname: Schonbrun
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Dylan
authors.initials: D
authors.lastname: Chivian
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: David E
authors.initials: DE
authors.lastname: Kim
authors.affiliation: Vanderbilt University, Nashville, Tennesee.
authors.forename: Jens
authors.initials: J
authors.lastname: Meiler
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: Kira M S
authors.initials: KMS
authors.lastname: Misura
authors.affiliation: University of Washington, Seattle, Washington.
authors.forename: David
authors.initials: D
authors.lastname: Baker
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D030562:Databases, Protein; D008958:Models, Molecular; D008962:Models, Theoretical; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D016415:Sequence Alignment; D012984:Software