title: Physical-chemical characterization and polymorphism determination of two nimodipine samples deriving from distinct laboratories.
abstract: Knowing the characteristics of raw materials in pharmaceutical practice is both important and useful. Firstly, evaluating the physical-chemical properties of the substances that will be used must be the primary step for quality control in the pharmacy industry. This work aims at analyzing the physical-chemical characteristics of two nimodipine samples I and II derived from distinct laboratories through thermal analysis (DSC and TG/DTG), HPLC, crystallography, and microscopy. Thermal analysis showed that sample II was more unstable than I. Morphological differences concerning shape, size, and crystallinity of particles were visualized by scanning electron microscopy (SEM) and X-ray powder diffraction. To sum up, the techniques used in this study can be said to have been efficient in the characterization and evaluation of quality control of the raw material.
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. teomazon@yahoo.com
authors.forename: Teófilo Mazon
authors.initials: TM
authors.lastname: Cardoso
authors.forename: Patrik Oening
authors.initials: PO
authors.lastname: Rodrigues
authors.forename: Hellen Karine
authors.initials: HK
authors.lastname: Stulzer
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Segatto Silva
authors.forename: Jivaldo
authors.initials: J
authors.lastname: do Rosário Matos
mesh_terms: D002121:Calcium Channel Blockers / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D009553:Nimodipine / Q000737:chemistry*; D033362:Powder Diffraction; D011786:Quality Control; D013818:Thermogravimetry; D044366:Transition Temperature; D014961:X-Ray Diffraction
chemical_list: D002121:Calcium Channel Blockers; D009553:Nimodipine