title: Measurement of transcutaneous hemoglobin concentration by noninvasive white-light spectroscopy in infants.
abstract: OBJECTIVE
  To compare transcutaneously spectroscopically measured hemoglobin values with venous hemoglobin values in infants.
  
  
  METHODS
  Prospective study in healthy preterm and term infants who were breathing spontaneously.
  
  
  RESULTS
  Recordings were obtained from 85 stable infants (median gestational age at measurement: 36 weeks [range: 34-43 weeks]; median body weight: 1890 g [range: 1095-4360 g]). The spectroscopic hemoglobin values were corrected for inhomogeneous distribution of hemoglobin in the tissue. The venous and spectroscopic hemoglobin values were then compared by using the Bland-Altman method, which gave an error of <5%.
  
  
  CONCLUSIONS
  This pilot study could illustrate a good relation between the 2 methods for measuring hemoglobin. Larger studies are required to validate the spectroscopic method in those with conditions that affect the skin microcirculation (eg, septicemia).
authors.affiliation: Department of Neonatology, Brighton and Sussex University Hospitals NHS Trust, Brighton BN2 5BE, United Kingdom. heike.rabe@bsuh.nhs.uk
authors.forename: Heike
authors.initials: H
authors.lastname: Rabe
authors.forename: Natascha
authors.initials: N
authors.lastname: Stupp
authors.forename: Murat
authors.initials: M
authors.lastname: Ozgün
authors.forename: Erik
authors.initials: E
authors.lastname: Harms
authors.forename: Holger
authors.initials: H
authors.lastname: Jungmann
mesh_terms: D002196:Capillaries; D005865:Gestational Age; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008833:Microcirculation; D012867:Skin / Q000098:blood supply*; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods; D014680:Veins
chemical_list: D006454:Hemoglobins