[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy].
OBJECTIVE
To study the influence of thermochemotheraphy on the expression of HSP70 in maxillofacial squamous cell carcinoma.


METHODS
12 patients were treated with thermochemotheraphy twice a week, altogether 10 times. After 8 mg of Pingyangmycin infused, the patients were treated with microwave hyperthermia at 43 degrees C for 40 min. The part of carcinoma tissue was removed with surgical operations at before treatment and aftre five times of treatment. The expression of HSP70 in tumor cells was determined by SP immunohistochemcial method.


RESULTS
The expression of HSP70 in tumor cells was enhanced obviously by thermochemotherapy.


CONCLUSIONS
Special high expression of HSP70 in the tumor cells was induced by thermochemotherapy. With the antigen presenting action and other action, HSP70 have special antitumor effect.
Wang
Sheng-Zhi
SZ
Dept. of Oral and Maxillofacial Surgery, The Affiliated Yantai Yu Huang Ding Hospital of Medical College, Qingdao Unitersity, Yantai 264000, China.
Wang
Li
L
Gao
Xiang-Dong
XD
Cheng
Zhou
Z
Bi
Hong-Guang
HG
Wang
Da-Zhang
DZ
D002294:Carcinoma, Squamous Cell; D018840:HSP70 Heat-Shock Proteins; D006801:Humans
D018840:HSP70 Heat-Shock Proteins