Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae.
The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated. Bioassay-guided fractionation of the crude extract, monitored by larvicidal assay, led to the isolation of a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol). This compound was quite potent against A. aegypti larvae (LC50 26.3 microg/ml).
Rodrigues
A M S
AM
Laboratório de Farmacognosia, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, Brazil.
de Paula
J E
JE
Roblot
F
F
Fournet
A
A
Espíndola
L S
LS
D000330:Aedes; D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry
D007306:Insecticides; D009285:Naphthoquinones; C008252:lapachol