title: An integrated approach to the characterization of cell movement.
abstract: BACKGROUND
  Most phenomena in developmental biology involve or depend upon cell migration. This article describes a comprehensive framework for the characterization and analysis of trajectories defined by cell movement. The following two perspectives are considered: (a) the behavior of each individual cell and (b) interactions between neighboring pairs of cells.
  
  
  METHODS
  The measurements considered for individual trajectories include the velocity magnitude and orientation, maximum spatial dispersion, displacement effectiveness, and displacement entropies. Interactions between two trajectories are characterized by comparing the respective velocities.
  
  
  RESULTS
  The potential of the overall framework is illustrated using data of moving cells in different biological environments. The work shows that it is possible to use the new algorithm presented here to characterize cell motility.
  
  
  CONCLUSIONS
  The features of the algorithm were successful in determining the motility changes under different experimental conditions.
authors.affiliation: Institute of Physics at São Carlos (IFSC), University of São Paulo (USP), Sao Carlos, Brazil. luciano@if.sc.usp.br
authors.forename: Luciano da Fontoura
authors.initials: Lda F
authors.lastname: Costa
authors.forename: Leandro Carrijo
authors.initials: LC
authors.lastname: Cintra
authors.forename: David
authors.initials: D
authors.lastname: Schubert
mesh_terms: D000465:Algorithms; D002450:Cell Communication; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D003584:Cytological Techniques; D019277:Entropy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007668:Kidney / Q000166:cytology; D018715:Microscopy, Video; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000494:pharmacology
chemical_list: D009419:Nerve Tissue Proteins