title: Photoreactive threading agent that specifically binds to abasic sites in DNA.
abstract: We report the synthesis and study of a photoreactive nitrobenzamide containing acridine that specifically interacts at abasic site in DNA by threading intercalation and introduces under irradiation a lesion on the opposite strand at the unpaired pyrimidine.
authors.affiliation: LEDSS UMR 5616 and ICMG-FR2607, Université Joseph Fourier, BP 53, 38041 Grenoble Cédex 9, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Martelli
authors.forename: Muriel
authors.initials: M
authors.lastname: Jourdan
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Constant
authors.forename: Martine
authors.initials: M
authors.lastname: Demeunynck
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
mesh_terms: D000166:Acridines / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004260:DNA Repair; D019281:Dimerization; D004591:Electrophoresis, Polyacrylamide Gel; D007364:Intercalating Agents / Q000494:pharmacology*; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D009578:Nitrobenzenes / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry; D011522:Protons; D011743:Pyrimidines / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics
chemical_list: D000166:Acridines; D001549:Benzamides; D007364:Intercalating Agents; D009578:Nitrobenzenes; D009841:Oligonucleotides; D011522:Protons; D011743:Pyrimidines; D004247:DNA; C036077:nitrobenzene; C030986:pyrimidine