A facile domino metathetic route to a thapsigargin skeleton.
A facile synthesis of a 5,7,5-fused ring system that is present in thapsigargins belonging to a novel family of sesquiterpene lactones, guainanolides, using domino enyne-RCM is reported here.
Kaliappan
Krishna P
KP
Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400 076, India. kpk@iitb.ac.in
Nandurdikar
Rahul S
RS
D008968:Molecular Conformation; D013237:Stereoisomerism; D019284:Thapsigargin / Q000138:chemical synthesis* / Q000737:chemistry
D019284:Thapsigargin