Microbial glycosylation and acetylation of brefeldin A.
The brefeldin A (BFA) derivatives 4-O-acetyl BFA, 7-O-acetyl BFA, and 4-O-D-glucosyl BFA were found by the microbial conversion of BFA. 4-O-D-Glucosyl BFA is a novel compound produced by the conversion of BFA with Streptomyces sp. Q53834. The cytotoxicity and antifungal activity of all of the compounds were markedly less than those of BFA.
Shibazaki
Mitsuyoshi
M
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. shibazak@yamanouchi.co.jp
Yamaguchi
Hiroshi
H
Sugawara
Takeo
T
Suzuki
Kenichi
K
Yamamoto
Tomoko
T