title: Regression of long standing anorexia nervosa following acute renal failure caused by gentamicin intoxication.
abstract: A female patient aged 22 with fully developed symptoms of anorexia nervosa presented the following metabolic disturbances: persistent hyperuricemia, hyponatruria, (sometimes with sodium lack in urine) as well as frequent hyponatremia and hyper-uricosuria. The patient's low arterial blood pressure (70/40 mm Hg on average) was not improved by pharmacological treatment, and only high oral doses of table salt (20-70 g/24 h) did prove effective in the therapy. The subject passed seven renal calculi composed of sodium urate and uric acid. Numerous urinalyses did not reveal any changes, and bacterial cultures of the urine were also negative. After 14 years of anorexia nervosa, the patient was treated for pneumonia with gentamicin at doses of 2 x 80 mg/24 h. Following third dose of the antibiotic, the patient developed acute renal failure and was treated by haemodialysis for six weeks. The renal function came gradually to the norm. Simultaneously, all the anorexia nervosa symptoms subsided along with sodium metabolism disturbances, while purine metabolism disorders got considerably alleviated. The patient started to have her menstrual cycles again, gained 12 kg in body weight, and one year afterwards bore a son. A further 10-year follow-up period was free of any pathological changes except for a slight hyperuricemia. To the best of our knowledge, the similar case has not been reported in the medical literature and electronic data bases.
authors.affiliation: 1st Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk, Poland.
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Chodorowski
authors.forename: Bolesław
authors.initials: B
authors.lastname: Rutkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Sein Anand
authors.forename: Przemysław
authors.initials: P
authors.lastname: Rutkowski
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications / Q000503:physiopathology*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology; D012043:Regression, Psychology; D006435:Renal Dialysis; D013997:Time Factors; D014883:Water-Electrolyte Imbalance / Q000209:etiology*; D015430:Weight Gain
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins