title: Dynamic and reversibility of heterochromatic gene silencing in human disease.
abstract: In eukaryotic organisms cellular fate and tissue specific gene expression are regulated by the activity of proteins known as transcription factors that by interacting with specific DNA sequences direct the activation or repression of target genes. The post genomic era has shown that transcription factors are not the unique key regulators of gene expression. Epigenetic mechanisms such as DNA methylation, post-translational modifications of histone proteins, remodeling of nucleosomes and expression of small regulatory RNAs also contribute to regulation of gene expression, determination of cell and tissue specificity and assurance of inheritance of gene expression levels. The relevant contribution of epigenetic mechanisms to a proper cellular function is highlighted by the effects of their deregulation that cooperate with genetic alterations to the development of various diseases and to the establishment and progression of tumors.
authors.affiliation: Department of Cellular Biotechnology, University of Rome La Sapienza, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zardo
authors.forename: Francesco
authors.initials: F
authors.lastname: Fazi
authors.forename: Lorena
authors.initials: L
authors.lastname: Travaglini
authors.forename: Clara
authors.initials: C
authors.lastname: Nervi
mesh_terms: D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D020868:Gene Silencing; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006570:Heterochromatin / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics; D009707:Nucleosomes / Q000378:metabolism; D009838:Oligodeoxyribonucleotides; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D012313:RNA / Q000737:chemistry; D034622:RNA Interference; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic; D014212:Tretinoin / Q000378:metabolism
chemical_list: C408982:CPG-oligonucleotide; D002843:Chromatin; D006570:Heterochromatin; D006657:Histones; D009707:Nucleosomes; D009838:Oligodeoxyribonucleotides; D014212:Tretinoin; D012313:RNA; D004247:DNA