title: Endovascular coiling versus neurosurgical clipping for patients with aneurysmal subarachnoid haemorrhage.
abstract: BACKGROUND
  Patients who have had an aneurysmal subarachnoid haemorrhage (SAH) are at very high risk of rebleeding if the aneurysm is not treated. The standard treatment for several decades has been surgical clipping of the neck of the aneurysm. In recent years, an alternative, the introduction of detachable coils to occlude the aneurysm, has become more common.
  
  
  OBJECTIVE
  To compare the effects of endovascular coiling versus neurosurgical clipping in patients with aneurysmal subarachnoid haemorrhage.
  
  
  METHODS
  We searched the Cochrane Stroke Group Trials Register (last searched in February 2005). In addition we searched MEDLINE (1966 to January 2004) and EMBASE (1980 to January 2004), and contacted trialists.
  
  
  METHODS
  We included randomised trials in which endovascular coiling of aneurysms was compared with neurosurgical clipping in patients with SAH who have proven aneurysm.
  
  
  METHODS
  Two authors independently extracted the data and assessed trial quality. Trialists were contacted to obtain missing information.
  
  
  RESULTS
  We identified three randomised trials: two published and one unpublished. The trials included a total of 2272 patients (range per trial: 20 to 2143 patients). Most of the patients were in good clinical condition and had an aneurysm on the anterior circulation. After one year of follow up, the relative risk (RR) of poor outcome for coiling versus clipping was 0.76 (95% confidence interval (CI) 0.67 to 0.88). The absolute risk reduction was 7% (95% CI 4% to 11%). In the worst-case scenario analysis for poor outcome overall, the relative risk for coiling versus clipping was 0.81 (95% CI 0.70 to 0.92) and the absolute risk reduction was 6% (95% CI 2% to 10%). For patients with anterior circulation aneurysm the relative risk of poor outcome was 0.78 (95% CI 0.68 to 0.90) and the absolute risk decrease was 7% (95% CI 3% to 10%). For those with a posterior circulation aneurysm the relative risk was 0.41 (95% CI 0.19 to 0.92) and the absolute decrease in risk 27% (95% CI 6% to 48%).
  
  
  CONCLUSIONS
  The evidence comes mainly from one large trial. For patients in good clinical condition with ruptured aneurysms of either the anterior or posterior circulation we have firm evidence that, if the aneurysm is considered suitable for both surgical clipping and endovascular treatment, coiling is associated with a better outcome.
authors.affiliation: University Hospital Utrecht, Department of Neurology, PO Box 85500, Utrecht, Netherlands 3508 GA. g.j.e.rinkel@neuro.azu.nl
authors.forename: I
authors.initials: I
authors.lastname: van der Schaaf
authors.forename: A
authors.initials: A
authors.lastname: Algra
authors.forename: M
authors.initials: M
authors.lastname: Wermer
authors.forename: A
authors.initials: A
authors.lastname: Molyneux
authors.forename: M
authors.initials: M
authors.lastname: Clarke
authors.forename: J
authors.initials: J
authors.lastname: van Gijn
authors.forename: G
authors.initials: G
authors.lastname: Rinkel
mesh_terms: D017542:Aneurysm, Ruptured / Q000601:surgery / Q000628:therapy*; D004621:Embolization, Therapeutic; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery / Q000628:therapy*; D019635:Neurosurgical Procedures / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D015607:Stents; D013345:Subarachnoid Hemorrhage / Q000601:surgery / Q000628:therapy*