title: Vascular development in endometriosis.
abstract: Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.
authors.affiliation: Research Institute GROW, Department of Obstetrics and Gynaecology, University Hospital Maastricht, Maastricht, The Netherlands. patrick.groothuis@path.unimaas.nl
authors.forename: P G
authors.initials: PG
authors.lastname: Groothuis
authors.forename: A W
authors.initials: AW
authors.lastname: Nap
authors.forename: E
authors.initials: E
authors.lastname: Winterhager
authors.forename: R
authors.initials: R
authors.lastname: Grümmer
mesh_terms: D001808:Blood Vessels / Q000254:growth & development* / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D004715:Endometriosis / Q000503:physiopathology*; D004717:Endometrium / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010960:Plasminogen Activators / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism
chemical_list: D015849:Plasminogen Inactivators; D010960:Plasminogen Activators