Chemo-inducible gene therapy.
Chemo-inducible cancer gene therapy is a potential new treatment for solid tumors that may in part enhance the anti-tumor effects of chemotherapy while minimizing toxicity. This approach combines viral vectors expressing cytotoxic transgenes that can be transcriptionally activated by DNA-damaging agents. The development of chemo-inducible gene therapy has numerous implications for the treatment of both localized and metastatic disease in patients with solid tumors.
Mezhir
James J
JJ
Department of Surgery, University of Chicago Hospitals, Chicago, Illinois 60637, USA.
Schmidt
Hank
H
Yamini
Bakhtiar
B
Senzer
Neil N
NN
Posner
Mitchell C
MC
Kufe
Donald W
DW
Weichselbaum
Ralph R
RR
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D051766:Early Growth Response Protein 1 / Q000235:genetics; D019450:Genes, MDR / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000628:therapy*; D011401:Promoter Regions, Genetic / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects* / Q000528:radiation effects; D048069:Tumor Necrosis Factors / Q000235:genetics
D000970:Antineoplastic Agents; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D048069:Tumor Necrosis Factors; D004247:DNA