title: Lack of association between interferon-gamma receptor-1 polymorphism and pulmonary TB in Iranian population sample.
abstract: BACKGROUND
  Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-gammaR1.
  
  
  OBJECTIVE
  Determination of susceptibility to tuberculosis with polymorphism of IFN-gammaR1 gene.
  
  
  METHODS
  Study was prospective case-control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-gammaR1 gene was detected with Newport method. Data were analysed with SPSS version 11.
  
  
  RESULTS
  Mean age of patients and control were 55+/-20 and 53+/-13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-gammaR1 gene. In control group there were no mutations.
  
  
  CONCLUSIONS
  Genetically susceptibility to TB is not in 395 colon of IFN-gammaR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population.
authors.affiliation: National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran. mmirsaeidi@nritld.ac.ir
authors.forename: S M
authors.initials: SM
authors.lastname: Mirsaeidi
authors.forename: M
authors.initials: M
authors.lastname: Houshmand
authors.forename: P
authors.initials: P
authors.lastname: Tabarsi
authors.forename: M M
authors.initials: MM
authors.lastname: Banoei
authors.forename: L
authors.initials: L
authors.lastname: Zargari
authors.forename: M
authors.initials: M
authors.lastname: Amiri
authors.forename: S D
authors.initials: SD
authors.lastname: Mansouri
authors.forename: M H
authors.initials: MH
authors.lastname: Sanati
authors.forename: M R
authors.initials: MR
authors.lastname: Masjedi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D017471:Receptors, Interferon / Q000235:genetics*; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000235:genetics*; D000096743:Interferon gamma Receptor
chemical_list: D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor