Brain compression without global neuronal loss in meningiomas: whole-brain proton MR spectroscopy report of 2 cases.
We report the findings from whole-brain proton MR spectroscopy, quantifying the neuronal marker N-acetylaspartate (NAA), for 2 presurgical meningioma patients and 10 healthy controls. The patients' whole-brain NAA (WBNAA) concentrations were considerably elevated (3+ SDs) compared with healthy controls when excluding the tumors from brain volume; WBNAA levels normalized following correction to approximate "preneoplastic" brain size. These results suggest global neuronal preservation in these 2 patients while their brains were compressed by large, slowly growing, extra-axial masses.
Cohen
Benjamin A
BA
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA.
Knopp
Edmond A
EA
Rusinek
Henry
H
Liu
Songtao
S
Gonen
Oded
O
D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D011312:Pressure