title: [Practical application of nutritional assessment protein and inflammatory marker in the nutrition support team (NST)].
abstract: Recently nutrition support team (NST) has been established for the purpose of prevention of complications which are caused by nutrition disorders and reduction of the medical expenses. Although physical examinations and blood biochemical data had been used as the indexes evaluating nutritional of patients, they were not suitable for the evaluation for the short-term in-patient. On the contrary, serum albumin (ALB) has been wildly used as a nutritional marker. However, it is impossible to evaluate nutrition state for the short-term in-patient and acute phase disease patient accurately, because the plasma half-life is 21 days and it takes long time to detect the change in nutritional state by its value. Rapid turnover proteins (RTP), whose plasma half-life is shorter, has paid attention to evaluate nutritional state for the short-term in-patients and acute phase disease patients. Although, prognostic inflammatory and nutritional index (PINI) was considered as a useful maker for evaluating inflammatory and nutritional states using the concentrations of transthyretin (TTR), a RTP, alpha1-acid glycoprotein (alpha1-AG), a chronic inflammation marker, C reactive protein (CRP), a acute inflammation marker, and ALB, However, it has several pitfalls. We newly made serum amyloid A (SAA) index using SAA instead of CRP. When we compared SAA index with PINI in many diseases, it turned out that SAA index became a more effective index which reflected the patient condition than did PINI. As for this index, it is expected to be used by NST while further alternation may be needed.
authors.affiliation: Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556.
authors.forename: Takiko
authors.initials: T
authors.lastname: Tateishi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ueda
authors.forename: Shingo
authors.initials: S
authors.lastname: Himeno
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Tsuyuko
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nishi
authors.forename: Kuniko
authors.initials: K
authors.lastname: Mori
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Asonuma
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Inomata
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D015596:Nutrition Assessment; D018529:Nutritional Support; D011228:Prealbumin / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis
chemical_list: D011228:Prealbumin; D012709:Serum Albumin; D002097:C-Reactive Protein