Matrix metalloproteinase-2 inhibition and Zn2+-chelating activities of pyoverdine-type siderophores.
Pyoverdine-type siderophores from fluorescent Pseudomonas species were purified by Zn2+-chelate chromatography, and their matrix metalloproteinase-2 (MMP-2) inhibition and metal-ion-chelating activities were studied. Structurally different pyoverdines showed different MMP-2 inhibition activities, and the inhibition activity was correlated with Zn2+-chelating activity. The IC50 value of a pyoverdine ((P113A1)-2, MW 1187) for MMP-2 was 0.27 microg/ml (0.23 microM).
Shinozaki-Tajiri
Yukiko
Y
Institute of Applied Biochemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan.
Akutsu-Shigeno
Yukie
Y
Nakajima-Kambe
Toshiaki
T
Inomata
Shinji
S
Nomura
Nobuhiko
N
Uchiyama
Hiroo
H