Comparative study of taste disturbance by losartan and perindopril in healthy volunteers.
The aim of this study was to compare the degree of taste disturbance by losartan, an angiotensin II receptor blocker, with that of perindopril, an angiotensin-converting enzyme inhibitor. Perindopril erbumine (2 mg), losartan potassium (25 mg), or vehicle was given to Japanese volunteers (n = 7) for 14 days in a randomized, placebo-controlled, 3-way crossover design with a 14-day washout period. Gustometry by filter-paper test and electrogustometry were performed before and at the end of each trial. Plasma renin activity (PRA) and serum and salivary zinc concentrations were measured. One subject dropped out because of a perindopril-induced dry cough, but no one claimed a taste disturbance. Detection thresholds of 4 basic tastes (sweet, salty, sour, and bitter) by the paper-disc test and electrogustometry were significantly worsened, and plasma renin activity was elevated by the drugs, whereas the deteriorating effects of 2 drugs did not significantly differ. These drugs did not affect zinc concentrations in plasma and saliva. It was concluded that losartan and perindopril similarly alter taste sensitivity during repeated dosing of the drugs.
Tsuruoka
Shuichi
S
Department of Pharmacology, Division of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan. tsuru@jichi.ac.jp
Wakaumi
Michi
M
Araki
Nobutaka
N
Ioka
Takashi
T
Sugimoto
Kohichi
K
Fujimura
Akio
A
D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D044466:Asian People; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D019808:Losartan / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000493:pharmacokinetics / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D012463:Saliva / Q000737:chemistry; D013652:Taste Threshold / Q000187:drug effects*; D015032:Zinc / Q000032:analysis / Q000097:blood
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D012083:Renin; D015032:Zinc; D019808:Losartan; D020913:Perindopril