Antioxidant and nitric oxide synthase activation properties of Ganoderma applanatum.
In vitro evaluation of antioxidant activities of Ganoderma applanatum showed significant inhibition of lipid peroxidation, and potent hydroxyl radical scavenging activity when compared with standard drug catechin. IC50 values of crude, boiled and ethanolic extracts of G. applanatum were 604.8, 624 and 267 microg/ml, respectively in case of hydroxyl radical scavenging activity, and 441, 520.5 and 166.16 microg/ml, respectively in case of lipid peroxidation. Furthermore, crude, boiled and ethanolic extracts also increased significantly nitric oxide production (156.67, 121.88 and 742 pmole/mg dry wt/hr, respectively) over the control. The results of present investigation revealed that G. applanatum have potential therapeutic use.
Acharya
Krishnendu
K
Department of Botany, University of Calcutta, 35, Ballygange Circular Road, Kolkata 700 019, India. krishnendua@rediffmail.com
Yonzone
Parinita
P
Rai
Manjula
M
Rupa
Acharya
A
D000363:Agaricales; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D004789:Enzyme Activation; D000431:Ethanol / Q000378:metabolism; D032902:Ganoderma / Q000378:metabolism*; D017665:Hydroxyl Radical; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D017382:Reactive Oxygen Species; D013481:Superoxides
D000975:Antioxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D013481:Superoxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D000431:Ethanol; D002392:Catechin; D019001:Nitric Oxide Synthase