Pathogen recognition: TLRs throw us a curve.
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors (PRRs) envisioned by as innate sensors of pathogen attack and host triggers of an adaptive immune response. Two recent papers (Choe et al., 2005; Bell et al., 2005) reveal the distinctive architecture of a TLR sensor domain and hint at how this structural design facilitates the recognition of a wide array of pathogen molecules.
Kirk
Peter
P
Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080, USA.
Bazan
J Fernando
JF
D018360:Crystallography, X-Ray; D007239:Infections / Q000276:immunology*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D051196:Toll-Like Receptor 3 / Q000737:chemistry / Q000276:immunology; D051193:Toll-Like Receptors / Q000737:chemistry / Q000276:immunology*
D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors