title: Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton.
abstract: [structure: see text] Two novel triterpene dilactones with an unprecedented rearranged hexacyclic skeleton, kadlongilactones A (1) and B (2), have been isolated from the leaves and stems of Kadsura longipedunculata Finet et Gagnep (Schisandraceae). Their structures were established by comprehensive 1D and 2D NMR spectroscopic analysis, coupled with single-crystal X-ray crystallographic diffraction. Compounds 1 and 2 exerted significant inhibitory effects against human tumor K562 cells with IC(50) = 1.40 and 1.71 microg/mL, respectively.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Qi-Tai
authors.initials: QT
authors.lastname: Zheng
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029633:Schisandraceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D007783:Lactones; D014315:Triterpenes; C512917:kadlongilactone A; C512916:kadlongilactone B