title: [Bone mineral density after treatment for nasal polyposis].
abstract: OBJECTIVE
  Medical treatment of nasal polyposis is based on corticotherapy, and the most frequent complication of long-term corticotherapy is corticosteroid-induced osteoporosis.
  
  
  OBJECTIVE
  To assess bone mineral density after long-term, high-dose corticosteroid treatment for nasal polyposis.
  
  
  METHODS
  Bone mineral density at the spine and hip was measured by absorptiometry in 32 patients who had received high doses of corticosteroids for nasal polyposis. None of them had a disease that interfered with bone mineral density
  
  
  RESULTS
  Bone mineral density was measured in 32 patients (59% men) aged 49.7 +/- 3.7 years [range: 29 - 74] after corticosteroid therapy for a mean of 5.3 years [range: 2-22 years]. More than 70% of the patients had abnormal bone density (osteopenia or osteoporosis ) at the spine and 44% at the hip. Only eight (25%) patients had normal bone density at both the spine and hip.
  
  
  CONCLUSIONS
  High doses of corticosteroids in the treatment of nasal polyposis affect bone mineral density. Assessment of the benefits and risks of endoscopic sinus surgery must take this iatrogenic risk into account.
authors.affiliation: Laboratoire de recherche ORL et service d'ORL et de chirurgie cervico-faciale, Formation associée Claude Bernard et Unité CNRS UPRESSA 7060, Hôpital Européen Georges Pompidou, Faculté Necker-Enfants malades, Université René Descartes, Paris.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Norès
authors.forename: Céline
authors.initials: C
authors.lastname: Mutschler
authors.forename: David
authors.initials: D
authors.lastname: Malinvaud
authors.forename: Philippe
authors.initials: P
authors.lastname: Halimi
authors.forename: Pierre
authors.initials: P
authors.lastname: Bonfils
mesh_terms: D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000188:drug therapy*; D010024:Osteoporosis / Q000139:chemically induced*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones