title: Practical asymmetric preparation of azetidine-2-carboxylic acid.
abstract: [reaction: see text] Facile and straightforward syntheses of both enantiomers of azetidine-2-carboxylic acid are described. The syntheses depart from inexpensive chemicals and allow for the production, in five to six steps, of practical quantities of each enantiomer. Synthetic highlights include the construction of the azetidine ring using an intramolecular alkylation and the use of optically active alpha-methylbenzylamine as chiral auxiliary.
authors.affiliation: Laboratoire SIRCOB, UMR CNRS 8086, Université de Versailles Saint Quentin en Yvelines, France.
authors.forename: Francois
authors.initials: F
authors.lastname: Couty
authors.forename: Gwilherm
authors.initials: G
authors.lastname: Evano
authors.forename: Monica
authors.initials: M
authors.lastname: Vargas-Sanchez
authors.forename: Gloria
authors.initials: G
authors.lastname: Bouzas
mesh_terms: D001383:Azetidinecarboxylic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001383:Azetidinecarboxylic Acid