title: [Dilated cardiomyopathy and lipid-lowering drug muscle toxicity revealing late-onset Becker's disease].
abstract: BACKGROUND
  The Becker's muscular dystrophy is a genetic myopathy due to mutations of the dystrophin gene, located in the Xp21 region, with a clinical expression usually occurring in young adults.
  
  
  METHODS
  We report an atypical case of late onset Becker's muscular dystrophy diagnosed at the age of 57. The patient suffered from mild skeletal muscle involvement revealed by the use of statins and fibrates, associated with severe dilating cardiomyopathy. The DNA analysis showed a deletion of the exons 11-13 in the Xp21 gene.
  
  
  CONCLUSIONS
  The diagnostic of Becker's muscular dystrophy must be considered in all patients with persistently elevated CPK and/or primitive dilated cardiomyopathy, whatever the age of the patient.
authors.affiliation: Service de médecine interne et maladies infectieuses, hôpital Saint-André, 1, rue Jean-Burguet, 33075 Bordeaux cedex, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Vandenhende
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
authors.forename: L
authors.initials: L
authors.lastname: Sailler
authors.forename: S
authors.initials: S
authors.lastname: Bouillot
authors.forename: P
authors.initials: P
authors.lastname: Morlat
authors.forename: J
authors.initials: J
authors.lastname: Beylot
mesh_terms: D017668:Age of Onset; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D017353:Gene Deletion; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000150:complications* / Q000175:diagnosis*
chemical_list: D000960:Hypolipidemic Agents