title: Hydrolysed milk in preterm infants: an open problem.
abstract: OBJECTIVE
  To review knowledge about the role, indications and nutritional adequacy of protein hydrolysate formulas (HF) in the preterm newborn.
  
  
  METHODS
  A review of the available literature was carried out.
  
  
  RESULTS
  No data support the use of HF for atopy prevention. HF could have a positive role in the early feeding of very-low-birthweight infants, but several concerns exist about their nutritional adequacy.
  
  
  CONCLUSIONS
  Further investigations addressing protein and mineral metabolism as well as long-term effects, including neurodevelopment, are needed.
authors.affiliation: Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Rome, Italy. zuppaaa@rm.unicatt.it
authors.forename: Antonio A
authors.initials: AA
authors.lastname: Zuppa
authors.forename: Federica
authors.initials: F
authors.lastname: Visintini
authors.forename: Francesco
authors.initials: F
authors.lastname: Cota
authors.forename: Luca
authors.initials: L
authors.lastname: Maggio
authors.forename: Costantino
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tortorolo
mesh_terms: D002657:Child Development / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D016269:Milk Hypersensitivity / Q000517:prevention & control*; D008895:Milk, Human / Q000737:chemistry*; D009751:Nutritional Requirements; D018529:Nutritional Support; D011492:Protein Hydrolysates / Q000737:chemistry*
chemical_list: D011492:Protein Hydrolysates