Influence of commonly used drugs on the accuracy of cystatin C-derived glomerular filtration rate.
There is controversy about the effect of certain drugs on cystatin C (CysC) concentrations, which would limit the usability of CysC for estimation of glomerular filtration rate (GFR) in patients with renal disease. Seventy-one children (ages 2.6 months to 18 years) with renal disease and on at least one study medication (tacrolimus, cyclosporine, mycophenolate mofetil, corticosteroids, fosinopril, ramipril and enalapril, losartan, cotrimoxazole) were tested in 85 nuclear medicine GFR clearance studies with simultaneous CysC determinations. We analyzed the relationship between the dose per kilogram and the ratio of the measured GFR to the CysC-derived GFR, with a ratio of 1 resembling agreement. A non-zero slope in linear regression analysis was considered significant for a drug effect on CysC. No significant relationship was found between the doses of the medication and the cystatin C GFR for any of the medications. Only cotrimoxazole showed a GFR ratio that was significantly lower than 1, which may be related to small numbers; otherwise the value was always 1. CysC provides accurate data for calculating GFR independent of the drug doses studied and avoids the use of methods of direct GFR measurement.
Foster
Jennifer
J
Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario K1H 8L1, Canada.
Reisman
William
W
Lepage
Nathalie
N
Filler
Guido
G
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000188:drug therapy* / Q000652:urine*; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins