The extracellular matrix and the cytoskeleton in heart hypertrophy and failure.
Cell characteristics and phenotype depend on the nature of the extracellular matrix, the type and organization of integrins and cytoskeleton. The interactions between these components are poorly known at the myocyte level and during cardiac remodeling associated with cardiac hypertrophy and heart failure. We analyze here the nature and organization of extracellular matrix (ECM) proteins, cytoskeleton and integrins and their regulation by growth factors, such as angiotensin II, in normal myocyte growth and in pathological growth (hypertrophy) of the myocardium and heart failure.
Jane-Lise
S
S
U127 INSERM, IFR Circulation Paris 7.
Corda
S
S
Chassagne
C
C
Rappaport
L
L
D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007797:Laminin / Q000378:metabolism; D045726:Metalloproteases / Q000378:metabolism; D012016:Reference Values; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000502:physiology*
D003598:Cytoskeletal Proteins; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D016023:Integrins; D007797:Laminin; D045726:Metalloproteases