Invasive aspergillosis of the central nervous system after allogeneic stem cell transplantation.
Central nervous system aspergillosis is a rare infectious complication in patients submitted to allogeneic stem cell transplantation. When it arises, this infection appears early post-transplant and most patients present with multiple central nervous system lesions. We report the clinical case of a 52 year old woman with IgGk multiple myeloma in relapse after a matched related allogeneic bone marrow transplant, who presented with a single large central nervous system Aspergillus lesion 11 months post-transplant in the setting of acute graft vs. host disease developing after the infusion of donor leucocytes. Although liposomal amphotericin B was promptly instituted, the patient died 1 week after the diagnosis.
Lacerda
João F
JF
Hematology, Neurosurgery and Radiology Services, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal. jflacerda@netcabo.pt
Martins
Carlos
C
Carmo
José A
JA
Lourenço
F
F
Guedes
M Moura
MM
Sequeira
Paulo
P
Lacerda
J M F
JM
D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000382:microbiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology; D020314:Central Nervous System Fungal Infections / Q000000981:diagnostic imaging / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011859:Radiography; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects*