title: Exposure to CB-153 and p,p'-DDE and bone mineral density and bone metabolism markers in middle-aged and elderly men and women.
abstract: The incidence of osteoporotic fractures is rising in western societies, partly due to unknown reasons. Persistent organochlorine compounds (POC) have in animal studies impaired the normal bone metabolism and resulted in increased bone fragility, which might have health implications for POC-exposed human populations. The aim of the present study was to assess whether a high dietary intake of POC through fatty fish from the Baltic may result in decreased bone mineral density (BMD) or disturbances in biochemical markers of bone metabolism. From a study base of fishermen and fishermen's wives from the Swedish east coast who are considerably more POC-exposed than the general Swedish population, 196 men (median age 59 years) and 184 women (median age 62 years) participated in an examination of their forearm BMD, using dual energy x-ray absorptiometry (DXA). Further, POC exposure was assessed by analysis of lipid-adjusted serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE). Cadmium in urine (U-Cd) was also analyzed. Biochemical markers in serum of osteoblastic (osteocalcin) and osteoclastic (CrossLaps) functions were measured. Adjustment for potential confounders was made by employing multiple regression analyses. Univariate analyses showed significant negative associations between CB-153 concentrations and BMD, but after adjustment for age and body mass index, these associations did not remain. None of the POC exposure variables were associated with CrossLaps or osteocalcin. There were no significant associations between U-Cd and BMD or any of the biochemical biomarkers. In conclusion, the results did not provide any support for the hypothesis that the current exposure levels to POC constitute a hazard for impaired bone metabolism in the general Swedish population.
authors.affiliation: Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, 221 85, Lund, Sweden.
authors.forename: Ewa
authors.initials: E
authors.lastname: Wallin
authors.forename: Lars
authors.initials: L
authors.lastname: Rylander
authors.forename: Bo A G
authors.initials: BA
authors.lastname: Jönssson
authors.forename: Thomas
authors.initials: T
authors.lastname: Lundh
authors.forename: Anders
authors.initials: A
authors.lastname: Isaksson
authors.forename: Lars
authors.initials: L
authors.lastname: Hagmar
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000818:Animals; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002104:Cadmium / Q000652:urine; D015331:Cohort Studies; D003094:Collagen / Q000097:blood; D003633:Dichlorodiphenyl Dichloroethylene / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity; D004032:Diet; D004781:Environmental Exposure / Q000009:adverse effects; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity; D005260:Female; D005399:Fishes; D005506:Food Contamination; D005542:Forearm; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D002104:Cadmium; D015675:Osteocalcin; D003633:Dichlorodiphenyl Dichloroethylene; D003094:Collagen; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl