title: Highly stereoselective reductions of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters catalyzed by isolated NADPH-dependent ketoreductases.
abstract: [reaction: see text] The biocatalytic reduction of alpha-alkyl-1,3-diketones and alpha-alkyl-beta-keto esters employing 1 of 20 different isolated NADPH-dependent ketoreductases proved to be a highly efficient method for the preparation of optically pure keto alcohols or hydroxy esters.
authors.affiliation: Department of Chemistry, University of Crete, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kalaitzakis
authors.forename: J David
authors.initials: JD
authors.lastname: Rozzell
authors.forename: Spiros
authors.initials: S
authors.lastname: Kambourakis
authors.forename: Ioulia
authors.initials: I
authors.lastname: Smonou
mesh_terms: D002384:Catalysis; D004952:Esters / Q000737:chemistry* / Q000378:metabolism; D007659:Ketones / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009249:NADP / Q000737:chemistry*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004952:Esters; D007659:Ketones; D009249:NADP; D010088:Oxidoreductases