Neuroprotective properties of statins.
Treatment with statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) reduces the risk of ischemic stroke among patients with increased risk of vascular disease. Recent experimental data point to neuroprotective properties of statins in acute cerebral ischemia. There is a proven link between bioavailability of nitric oxide and the activity of statins and ischemic stroke. Due to their ability to up-regulate nitric oxide synthase, statins have been considered in the therapy of a number of the central nervous system disorders, including cerebral ischemia, Alzheimer's disease, Parkinson's disease, tumors, and trauma. It has been claimed that they suppress inflammatory response and secondary injury after acute ischemia.
Stepień
Karolina
K
Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Tomaszewski
Michał
M
Czuczwar
Stanisław J
SJ
D000544:Alzheimer Disease / Q000517:prevention & control; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000517:prevention & control; D019636:Neurodegenerative Diseases / Q000517:prevention & control; D018696:Neuroprotective Agents; D009569:Nitric Oxide / Q000378:metabolism; D020521:Stroke / Q000517:prevention & control
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018696:Neuroprotective Agents; D009569:Nitric Oxide