[Effects of different diet composition after weaning on the obesity in rats induced by high-energy diet].
OBJECTIVE
To explore the effects of different diet composition on the obesity in rats induced by high-fat diet after weaning.


METHODS
Male Wistar rats weaned on 24 days were randomly divided into groups A, B and C and were assigned to high carbohydrate, i.e. basic diet, high protein, high non-saturated fat diets respectively for 3 weeks. Then all groups were fed with basic diet. After 2 weeks, rats from group A were randomly divided into groups A1 and A2, A1 was assigned to basic diet continuously and groups A2, B, C were fed with high-fat diet for 6 weeks. 8 rats from each group were sacrified at the end of different treatments to detect serum glucose, TG and hormones dynamicly.


RESULTS
High nonsaturated fat diet after weaning significantly reduced the body weight, body fat content, increased the sensitiveness to insulin, the levels of glucagons, FT4, FT3, improved leptin resistance in rats fed with high-fat diet. High-protein diet also reduced body weight, body fat content and increase lipolysis in rats fed with high-fat diet, but blood glucose in which group was higher than in group A2.


CONCLUSIONS
High non-saturated fat diet after weaning can significantly reduce the obesity of rats fed with high-fat diet.
Zhang
Xiao-Hong
XH
School of Public Health, Harbin Medical University, Harbin 150086, China.
Sun
Chang-Hao
CH
Wang
Shu-Ran
SR
Wang
Xiao-Chun
XC
Zhao
Lijun
L
D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D002149:Energy Intake; D004734:Energy Metabolism; D008297:Male; D009765:Obesity / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar; D014886:Weaning
D004041:Dietary Fats