Bioscaffolds in tissue engineering: a rationale for use in the reconstruction of musculoskeletal soft tissues.
Bioscaffolds derived from animal tissues can be an appealing substrate to induce the formation of functional tissue (histogenesis) within the context of tissue engineering. Bioscaffolds obtained from the extracellular matrix not only contain collagen, which can provide mechanical support, but also include the required biologically active molecules that provide a stimulus for active tissue remodeling. Manufacturing, processing, and the tissue source of the biological scaffold affect the biologic outcome and are important in predicting the clinical results. This article discusses the merits and limitations of using bioscaffolds in soft tissue engineering.
De Deyne
Patrick G
PG
DePuy Biologics/Soft Tissue Technologies, 325 Paramount Drive, Raynham, MA 02767, USA. pdedeyne@dpyus.jnj.com
Kladakis
Stephanie M
SM
D000818:Animals; D005109:Extracellular Matrix; D006801:Humans; D009132:Muscles / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D016378:Tissue Transplantation / Q000379:methods