title: Matrix metalloproteinase-2 inhibition and Zn2+-chelating activities of pyoverdine-type siderophores.
abstract: Pyoverdine-type siderophores from fluorescent Pseudomonas species were purified by Zn2+-chelate chromatography, and their matrix metalloproteinase-2 (MMP-2) inhibition and metal-ion-chelating activities were studied. Structurally different pyoverdines showed different MMP-2 inhibition activities, and the inhibition activity was correlated with Zn2+-chelating activity. The IC50 value of a pyoverdine ((P113A1)-2, MW 1187) for MMP-2 was 0.27 microg/ml (0.23 microM).
authors.affiliation: Institute of Applied Biochemistry, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Shinozaki-Tajiri
authors.forename: Yukie
authors.initials: Y
authors.lastname: Akutsu-Shigeno
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima-Kambe
authors.forename: Shinji
authors.initials: S
authors.lastname: Inomata
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Nomura
authors.forename: Hiroo
authors.initials: H
authors.lastname: Uchiyama