MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York.
Excessive oxidative stress may induce and promote breast carcinogenesis. Manganese superoxide dismutase (MnSOD) is critical to management of oxidative stress by catalyzing the formation of hydrogen peroxide from two superoxide anions. To examine the relationship between MnSOD Val-9Ala polymorphism, breast cancer and potential modifiers, we analyzed data from a large population-based case-control study. Study participants completed an in-home interviewer-administered questionnaire, and self-completed a Block food frequency questionnaire. Age-adjusted unconditional logistic models included 1034 cases and 1084 controls. As compared with Val/Val genotype, we found no association between MnSOD Ala/Val (OR = 0.98, 95% CI: 0.79-1.21) and Ala/Ala (OR = 1.00, 95% CI: 0.79-1.28) genotypes and breast cancer. Results did not differ by menopausal status, stage of tumor, or estrogen and progesterone receptor status. No discernable patterns of interaction were found between this MnSOD variant and anti-oxidative exposures, including fruit and vegetable intake or NSAID use, or pro-oxidant exposures, including smoking and alcohol. This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk.
Gaudet
Mia M
MM
Department of Epidemiology, School of Public Health, University of North Carolina, CB# 7435, Chapel Hill, NC 27599-7435, USA. gaudet@email.unc.edu
Gammon
Marilie D
MD
Santella
Regina M
RM
Britton
Julie A
JA
Teitelbaum
Susan L
SL
Eng
Sybil M
SM
Terry
Mary Beth
MB
Bensen
Jeannette T
JT
Schroeder
Jane
J
Olshan
Andrew F
AF
Neugut
Alfred I
AI
Ambrosone
Christine B
CB
D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D005838:Genotype; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D009518:New York / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013482:Superoxide Dismutase / Q000235:genetics*; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
D014028:Tobacco Smoke Pollution; D013482:Superoxide Dismutase