title: Radiologic features and treatment outcomes of pulmonary metastasis in gestational trophoblastic neoplasia.
abstract: OBJECTIVE
  To evaluate the radiologic patterns and treatment outcome of pulmonary metastasis in patients with gestational trophoblastic tumor (GTT).
  
  
  METHODS
  The medical records and chest films of GTT patients treated at Chiang Mai University Hospital between January 1998 and June 2003 were reviewed.
  
  
  RESULTS
  There were 85 GTT-patients in the study period. 32 cases (37.6%) had pulmonary metastasis diagnosed with chest X-rays. The most common radiologic pattern was well defined nodule. The radiologic features of patients who had lung metastases alone were not significantly different from those who had associated metastases in other organs. 27 patients (84.3%) received multiple chemotherapy and 6 required more than one regimen. The mean number of chemotherapy was 7 cycles (range 3-23). Adjuvant surgery consisted of hysterectomy (11), salpingo-oophorectomy (1), thoracotomy (2), and craniotomy (1). Four patients received whole brain irradiation for brain metastases. Among 10 patients with lung metastasis alone, 8 (80%) attained complete remission, the remaining 2 patients were lost to follow-up. Among 22 patients with associated multiple organ metastases, 16 (72.7%) had complete remission, 2 died from diseases, 4 were lost to follow-up.
  
  
  CONCLUSIONS
  The most common radiologic pattern of pulmonary metastasis in GTT patients was well-defined multiple lung nodules. The radiologic features of patients who had lung metastases alone were not significantly different from those who developed metastases in other organs.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. psuprase@mail.med.cmu.ac.th
authors.forename: Prapaporn
authors.initials: P
authors.lastname: Suprasert
authors.forename: Juntima
authors.initials: J
authors.lastname: Eua-Throngchit
authors.forename: Jatupol
authors.initials: J
authors.lastname: Srisomboon
authors.forename: Kittipat
authors.initials: K
authors.lastname: Charoenkwan
authors.forename: Sitthicha
authors.initials: S
authors.lastname: Siriaree
authors.forename: Chailert
authors.initials: C
authors.lastname: Phongnarisorn
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D011859:Radiography; D015996:Survival Rate; D016896:Treatment Outcome