title: A family based study of the genetic association between the PLA2G4D gene and schizophrenia.
abstract: The present study detected two single nucleotide polymorphisms (SNPs) at the PLA2G4D locus, rs2459692 and rs4924618, to investigate a genetic association between the PLA2G4D gene and schizophrenia. A total of 236 Chinese parent-offspring trios of Han descent were recruited for the genetic analysis. The transmission disequilibrium test (TDT) did not show allelic association either for rs2459692 (chi(2) = 0.217, P = 0.641) or for rs4924618 (chi(2) = 0.663, P = 0.416). To see the combined effect of the PLA2G4D locus with the other three PLA2G4 genes, we applied the above two SNPs as a conditional marker to test the pair-wise combination for a disease association. The conditioning on allele (COA) test revealed a weak association for the rs2459692-PLA2G4A combination (chi(2) = 6.03, df = 2, P = 0.049), the rs2459692-PLA2G4B combination (chi(2) = 7.16, df = 3, P = 0.028) and the rs4924618-PLA2G4C combination (chi(2) = 7.01, df = 2, P = 0.03), whereas the conditioning on genotype (COG) test showed a weak association only for the rs4924618-PLA2G4C combination (chi(2) = 8.52, df = 3, P = 0.036). Because we performed a multi-locus analysis in this study, the weak association shown by the conditional tests could make little biological sense. In conclusion, the PLA2G4D gene may not be involved in a susceptibility to schizophrenia.
authors.affiliation: Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Tao
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Jieping
authors.initials: J
authors.lastname: Shi
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Guo
authors.forename: Chunxiu
authors.initials: C
authors.lastname: Wang
authors.forename: Baihui
authors.initials: B
authors.lastname: Han
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Xie
authors.forename: Shuzheng
authors.initials: S
authors.lastname: Liu
authors.forename: Guizhi
authors.initials: G
authors.lastname: Ju
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
mesh_terms: D000328:Adult; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D010741:Phospholipases A