Leptomeningeal cancer in the pediatric patient.
The treatment and prophylaxis of leptomeningeal leukemia and lymphoma in children has dramatically improved disease control and long-term survival. However, the treatment of other leptomeningeal cancers has been less successful and the neurologic morbidity associated with central nervous system-directed therapy has a significant long-term impact on quality of life. Further research is critical to identify new therapeutic strategies for children with or at high risk for leptomeningeal cancer.
Neville
Kathleen A
KA
Texas Children's Cancer Center, Baylor College of Medicine Houston, TX 77030, USA.
Blaney
Susan M
SM
D016543:Central Nervous System Neoplasms / Q000473:pathology; D002648:Child; D006801:Humans; D008223:Lymphoma / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary* / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology