title: Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.
abstract: OBJECTIVE
  Endoventricular patch plasty (the Dor procedure) has gained favor as a surgical treatment for heart failure associated with large anteroapical myocardial infarction. We tested the hypothesis that the Dor procedure reduces left ventricular volume, increases end-systolic elastance, decreases diastolic compliance, and maintains left ventricular function.
  
  
  METHODS
  In 6 male Dorsett sheep, the left anterior descending coronary artery and its second diagonal branch were ligated 40% of the distance from apex to base. Sixteen weeks after myocardial infarction, a Dor procedure was performed with a Dacron patch that was 50% of the infarct neck dimension. Absolute left ventricular volume was measured with magnetic resonance imaging, and left ventricular pressure and relative left ventricular volume changes during pharmacologic preload reduction were measured with a volume conductance catheter 2 weeks before and 2 and 6 weeks after the Dor procedure. End-systolic elastance, diastolic compliance, and Starling relationships were calculated from the resultant left ventricular pressure/volume loops.
  
  
  RESULTS
  Two weeks after the Dor procedure, the left ventricular volume at end systole and end diastole was significantly reduced, and there was no redilation at 6 weeks. Six weeks after the Dor procedure, the ejection fraction was significantly increased. Although stroke volume increased slightly at 6 weeks, the change was not significant. The slopes of end-systolic elastance, diastolic compliance, and Starling relationships were unchanged at 2 and 6 weeks.
  
  
  CONCLUSIONS
  The Dor procedure significantly reduces left ventricular volume. Unlike linear repair, left ventricular volume changes seem stable. The ejection fraction is improved, and left ventricular function (stroke volume and the Starling relationship) is maintained.
authors.affiliation: Department of Surgery, University of California, San Francisco, Calif, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Julius M
authors.initials: JM
authors.lastname: Guccione
authors.forename: Susan I
authors.initials: SI
authors.lastname: Nicholas
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Walker
authors.forename: Philip C
authors.initials: PC
authors.lastname: Crawford
authors.forename: Amin
authors.initials: A
authors.lastname: Shamal
authors.forename: David A
authors.initials: DA
authors.lastname: Saloner
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Wallace
authors.forename: Mark B
authors.initials: MB
authors.lastname: Ratcliffe
mesh_terms: D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods; D006322:Heart Aneurysm / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D012756:Sheep; D016277:Ventricular Function, Left