Gamma/delta T-cell receptor type granular lymphocyte proliferative disorder associated with rheumatoid arthritis.
We present here a case report of a 69-year-old female patient with T granular lymphocyte proliferative disorder (T-GLPD) expressing the gamma/delta T-cell receptor. The patient had been treated for rheumatoid arthritis for 25 years, and presented with mild anaemia. Cell-surface marker analysis was carried out using flow cytometry and natural killer function was determined using a chromium release assay. The case report is followed by a summary of the 21 other gamma/delta T-GLPD cases reported in the literature and a comparison of their clinical characteristics with those of T-GLPD cases expressing the alpha/beta T-cell receptor. The clinical symptoms and the frequency of association with rheumatoid arthritis are similar in gamma/delta and alpha/beta T-GLPD, but a prevalence of the CD8- cell-surface marker and enhanced natural killer function appear to be characteristics of gamma/delta T-GLPD.
Zenibayashi
M
M
Department of Medicine, Kakogawa Prefectural Hospital, Kakogawa, Hyogo, Japan.
Saigo
K
K
Chayahara
N
N
Sakamoto
Y
Y
Inujima
K
K
Imamura
Y
Y
Takada
M
M
Kawano
S
S
Tatsumi
E
E
Kumagai
S
S
D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets
D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D016692:Receptors, Antigen, T-Cell, gamma-delta