Effect of Cistus laurifolius L. leaf extracts and flavonoids on acetaminophen-induced hepatotoxicity in mice.
In this study, the effect of the flavonoids quercetin-3-methyl-ether (isorhamnetin) (1), quercetin-3,7-dimethyl-ether (2) and kaempferol-3,7-dimethyl-ether (3) isolated from Cistus laurifolius L. (cistaceae) leaves was assessed on lipid peroxidation (liver and plasma), cellular glutathione (GSH) level and plasma AST (aspartate aminotransferase), ALT (alanine aminotransferase) enzyme activities in acetaminophen-induced liver damage in mice. At 114 mg/kg oral dose quercetin-3,7-dimethyl-ether was shown to possess potent antioxidative activity.
Küpeli
Esra
E
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Hipodrom 06330, Ankara, Turkey. esrak@gazi.edu.tr
Orhan
Didem Deliorman
DD
Yesilada
Erdem
E
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D029758:Cistus / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D044948:Flavonols / Q000302:isolation & purification / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism; D044949:Kaempferols / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008107:Liver Diseases / Q000097:blood / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D014421:Turkey
D000975:Antioxidants; D005419:Flavonoids; D044948:Flavonols; D044949:Kaempferols; D010936:Plant Extracts; C047368:3-methylquercetin; C065497:3,7-dimethoxy-5,3',4'-trihydroxyflavone; D000082:Acetaminophen; D008315:Malondialdehyde; D011794:Quercetin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione