title: [Effectiveness of green tea catechines for the correction of the alimentary obesity in the experiment].
abstract: Obesity is one of the most important problems of the modern medicine. The immobile life-style and consumption of high-calorie food are the most remarkable risk-factors of the obesity, which in presence of genetic predisposition contribute to the increasing of the body weight. In the modern literature there are numerous data about the important role of free radical oxidation in the pathogenesis of the obesity. In this relation application of natural antioxidants for the purpose of the correction of excess weight has gained an active research interest. Numerous researches showed natural antioxidants to be effective in correction of elevated blood cholesterol, triglycerides and LDL levels. In this relation the purpose of our research was to investigate effectiveness of green tea catechizes on lipid metabolism disorder, antioxidant status and excess body weight during experimental alimentary obesity. Experiment was conducted on rats kept on high-calorie diet for 7 weeks. Simultaneously one group of animals had been administered catechines in addition to the high-calorie diet during last 4 weeks. The experiment established corrective effect of catechines on the parameters of lipid metabolism (blood cholesterol, triglyceride and LDL levels), epididymal fat mass and antioxidant enzymes activity. Obtained results may be important for the development of weight losing diets.
authors.affiliation: Institute of Medical Biotechnology, Georgian Academy of Sciences, Tbilisi State Medical University.
authors.forename: T
authors.initials: T
authors.lastname: Chanadiri
authors.forename: T
authors.initials: T
authors.lastname: Sanikidze
authors.forename: M
authors.initials: M
authors.lastname: Esaishvili
authors.forename: I
authors.initials: I
authors.lastname: Chkhikvishvili
authors.forename: I
authors.initials: I
authors.lastname: Datunashvili
mesh_terms: D000818:Animals; D028241:Camellia sinensis; D008066:Lipolysis / Q000187:drug effects; D009765:Obesity / Q000628:therapy*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013053:Spectrophotometry; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; C465546:green tea extract AR25