title: Salivary and serum interleukin 6 and basic fibroblast growth factor levels in patients with oral squamous cell carcinoma.
abstract: OBJECTIVE
  A role of various cytokines has been implicated in the pathogenesis of many carcinomas, and albeit the role of interleukin 6 (IL-6) and basic fibroblast growth factor (bFGF) in sera has been studied in patients with oral carcinomas, data upon salivary IL-6 and bFGF are lacking. The aim of this study was to evaluate levels of IL-6 and bFGF in the saliva and serum of patients with oral squamous cell carcinoma.
  
  
  METHODS
  Salivary and serum IL-6 and bFGF were evaluated in a group of 33 patients (28 men, 5 women) with oral squamous cell carcinoma (OSCC), age range 40-73 years , mean 54.05 years. Control group consisted of 23 healhy participants, mean age 25 years.
  
  
  RESULTS
  Serum IL-6 and bFGF levels were not significantly different between patients with OSCC and healthy controls. Elevated levels of salivary IL-6 and bFGF in patients with OSCC when compared to the healthy controls were found (p<0.001).
  
  
  CONCLUSIONS
  The conclusion is drawn that higher levels of salivary IL-6 and bFGF in patients with OSCC might originate from the local production, probably from carcinoma cells.
authors.affiliation: Department of Oral medicine, School of Dental Medicine, University of Zagreb Zagreb, Croatia. vvboras@hotmail.com
authors.forename: V
authors.initials: V
authors.lastname: Vucicević Boras
authors.forename: N
authors.initials: N
authors.lastname: Cikes
authors.forename: J
authors.initials: J
authors.lastname: Lukać
authors.forename: M
authors.initials: M
authors.lastname: Virag
authors.forename: A
authors.initials: A
authors.lastname: Cekić-Arambasin
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis* / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology*; D012463:Saliva / Q000737:chemistry*
chemical_list: D015850:Interleukin-6; D016222:Fibroblast Growth Factor 2