title: A highly efficient carbon-carbon bond formation reaction via nucleophilic addition to N-alkylaldimines without acids or metallic species.
abstract: A nucleophilic addition reaction to N-methylaldimines without acid or metal species is described. A novel reagent, dicyanomethyl acetate, is used as a nucleophile to give alpha-(N-methyl-N-acetyl)amino acid methyl esters in excellent yield.
authors.affiliation: Department of Molecular Design and Synthesis, Division of Pharmaceutical Chemistry, The University of Tokushima, 1-78, Sho-machi, Tokushima 770-8505, Japan. nem@ph.tokushima-u.ac.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Nemoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kawamura
authors.forename: Norikazu
authors.initials: N
authors.lastname: Miyoshi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D007097:Imines; D002244:Carbon