title: Analogues of N-terminal truncated synthetic peptide fragments derived from RANTES inhibit HIV-1 infectivity.
abstract: A series of synthetic peptide fragments derived from RANTES were designed, synthesized, and evaluated to determine the effect of N-terminal truncation on the ability of the lead compound Ac[Ala(10,11)]RANTES-(1-14)NH(2) to inhibit HIV-1 infectivity. Both the lead compound and the truncated analogue Ac[Ala(10,11)]RANTES-(3-14)NH(2) were able to significantly inhibit HIV-1 infectivity. These results suggest that a small synthetic peptide may be able to mimic RANTES and have the ability to prevent transmission of HIV-1.
authors.affiliation: Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06269, USA.
authors.forename: Emabelle J
authors.initials: EJ
authors.lastname: Ramnarine
authors.forename: Anthony L
authors.initials: AL
authors.lastname: Devico
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Vigil-Cruz
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D018946:Chemokine CCL5 / Q000494:pharmacology*; D015195:Drug Design; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D018946:Chemokine CCL5; D010446:Peptide Fragments; D010455:Peptides