title: Impact of emergency surgery in the outcome of rectal and left colon carcinoma.
abstract: The negative results in terms of morbidity, mortality and survival among emergency treated patients affected by colorectal cancer are well known. The specific contribution of emergency surgery to adverse outcome is not clear because of the presence in all series of other possible determinants of a poor prognosis. We used a case-control study design to compare a group of 50 patients operated on for cancer of the rectum and left colon presented as emergencies in our department during the last 14 years, and an equal number of patients who underwent elective procedures during the same period. All records of these patients were reviewed and matched for age, stage, tumor location, and medical comorbidities (coronaropathy, diabetes mellitus, cerebral vascular deficiency, chronic obstructive pulmonary disease). Outcome measures included length of hospital stay, morbidity, mortality, and actuarial 5-year survival. Univariate and multivariate analysis of factors potentially influencing survival was performed on the entire population of 100 patients. Age, tumor location, stage of disease, and medical comorbidities were well matched by intent of the study design. Overall surgical morbidity (44% versus 12% P = 0.0004), length of hospital stay (16, 64 versus 10, 97 days P = 0.0026) and postoperative mortality (4% versus 0% P = 0.4949) resulted higher in the emergency group. Actuarial overall 5-year survival was not different between the two groups. The only variables independently predictive of survival in multivariate analysis were age and rectal location of the tumor. Postoperative surgical mortality and long-term survival appear not to be influenced by emergency presentation of colorectal cancer; the negative impact of the emergency procedures is confined to the immediate postoperative period and is probably connected to the acute medical pathology often presented by patients in emergency situations. Dealing with this kind of patient's accurate preoperative assessment and solution of acute medical pathologies before surgical treatment are mandatory.
authors.affiliation: Department of Surgical Science, Catholic University of the Sacred Heart, Largo A. Gemelli 8, Rome 00161, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Coco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Verbo
authors.forename: Alberto
authors.initials: A
authors.lastname: Manno
authors.forename: Claudio
authors.initials: C
authors.lastname: Mattana
authors.forename: Marcello
authors.initials: M
authors.lastname: Covino
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pedretti
authors.forename: Luigi
authors.initials: L
authors.lastname: Petito
authors.forename: Gianluca
authors.initials: G
authors.lastname: Rizzo
authors.forename: Aurelio
authors.initials: A
authors.lastname: Picciocchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery*; D015897:Comorbidity; D013505:Digestive System Surgical Procedures; D004638:Emergency Treatment; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D012811:Sigmoid Neoplasms / Q000601:surgery; D016896:Treatment Outcome