title: Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and osteoporosis induced by a -6 degrees head-down bedrest.
abstract: We have reported that centrifuge-induced artificial gravity with ergometric exercise could reduce developing cardiovascular deconditioning in humans. In the present study, we examined this load could prevent the myatrophy and osteoporosis induced by head-down bedrest for 20 days. Subjects were ten healthy male volunteers with informed consent. They were requested to lie down at -6 degrees for 20 days, and evaluation for cardiovascular deconditioning, myatrophy, and osteoporosis. As the result, high G-load with low intensity exercise suppressed the orthostatic intolerance and increase in serum osteoporotic marker, whereas low G-load with high intensity ergometric exercise maintained the maximal oxygen intake, heart dimension, and prevented myatrophy. The combination of high/low G-load with low/high intensity exercise will determine the optimal protocol for prevention of cardiovascular deconditioning, myatrophy, and osteoporosis.
authors.affiliation: Dept. Physiol. II, Aichi Med. Univ., Aichi, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwase
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takada
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Ishida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akima
authors.forename: Keisho
authors.initials: K
authors.lastname: Katayama
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Iwase
authors.forename: Kaname
authors.initials: K
authors.lastname: Hirayanagi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Shiozawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Hamaoka
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Masuo
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Custaud
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000652:urine; D001510:Bed Rest / Q000009:adverse effects*; D015415:Biomarkers; D018488:Bone Demineralization, Pathologic / Q000517:prevention & control; D018493:Cardiovascular Deconditioning / Q000502:physiology*; D002498:Centrifugation; D004452:Echocardiography; D015444:Exercise / Q000502:physiology*; D018495:Fluid Shifts / Q000502:physiology; D018470:Gravity, Altered; D018475:Head-Down Tilt; D006339:Heart Rate; D006801:Humans; D018471:Hypergravity; D007024:Hypotension, Orthostatic / Q000517:prevention & control; D007866:Leg; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D009133:Muscular Atrophy / Q000517:prevention & control; D010101:Oxygen Consumption; D010953:Plasma Volume / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D018544:Weightlessness Countermeasures
chemical_list: D000596:Amino Acids; D015415:Biomarkers; C036020:deoxypyridinoline