[Do prothrombin time, transaminases, and platelet count predict the severity of fibrosis in viral liver diseases?].
The goal of our study is to assess the performance of a score combining 3 serological parameters (PT, platelets and transminases) in predictive hepatic fibrosis. The study involved 54 patients, 29 of which resulted in distributing them according to the score of Metavir into 2 groupes: Group A with mild fibrosis (F1,F2) and group B with severe fibrosis (F3,F4). PT, platelets and transminase values in serum were assessed for all patients. The total score of the 3 biological parameters combined, was significantly more elabled in the severe fibrosis group than in the mild fibrosis group (P = 0.01) but it was not of much importance in 30% of cases as it did not allow to classify the patients with certainty in group A or in group B. This score does not seem to grant exemption from needle liver biopsy, but it can be improved by the association of other direct markers of fibrosis.
Mohamed
Mossaddok Azzouz
MA
Service de Gastroentérologie, Hôpital Mohamed Tahar Maamouri de Naheul.
Majda
Essid
E
Mohamed
Ktari
K
Bechir
Zouari
Z
Sana
Kallel
K
Ehsène
Ben Brahim
BB
Samia
Chatti
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000821:virology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011517:Prothrombin Time; D012720:Severity of Illness Index; D000637:Transaminases / Q000097:blood*
D015415:Biomarkers; D000637:Transaminases