[Effects of cadmium on levels of insulin in rats].
OBJECTIVE
To explore the effect of cadmium on insulin in rats.


METHODS
96 of SD rats were administered with cadmium at different doses (0, 50, 100, 200 mg/L) by drinking water for 30 days, 60 days, and 90 days. The levels of insulin, the contents of cadmium in the blood, urine, and tissues (liver, kidney, and pancreas) were determined.


RESULTS
The level of insulin were decreased in the groups of 100 and 200 mg/L at the 30-day and in the group of 100 mg/L at the 60-day. Cadmium in blood and tissues (liver, kidney, and pancreas) were higher in exposed groups than those in control group. But the contents of cadmium in pancreas are lower than that in kidney and liver.


CONCLUSIONS
It is suggested that cadmium could be accumulated in pancreas. Then it maybe related to the change of the levels of insulin in serum.
Lei
Li-Jian
LJ
School of Public Health, Fudan University, Shanghai 200032, China.
Jin
Tai-Yi
TY
Zhou
Yuan-Fen
YF
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D007328:Insulin / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004785:Environmental Pollutants; D007328:Insulin; D002104:Cadmium