Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicity.
[Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency ( approximately 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.
Chen
Chunying
C
Lab for Bio-Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Xing
Gengmei
G
Wang
Jiangxue
J
Zhao
Yuliang
Y
Li
Bai
B
Tang
Jun
J
Jia
Guang
G
Wang
Tiancheng
T
Sun
Jin
J
Xing
Li
L
Yuan
Hui
H
Gao
Yuxi
Y
Meng
Huan
H
Chen
Zhen
Z
Zhao
Feng
F
Chai
Zhifang
Z
Fang
Xiaohong
X
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D037741:Fullerenes / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D007107:Immune System / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D000970:Antineoplastic Agents; D019187:Cadmium Compounds; D037741:Fullerenes; C000608549:Gd@C82(OH)22