Does antioxidant supplementation alter the effects of acute exercise on erythrocyte aggregation, deformability and endothelium adhesion in untrained rats?
This study aimed to determine whether high-dose antioxidant supplementation had an impact on the acute exercise effects related to erythrocyte membrane mechanics. Experimental animals (n=32) were divided into four groups as control, exercised, supplemented, and supplemented + exercise. Four-week antioxidant supplementation (vitamin C, vitamin E, and zinc) was applied to experimental animals. Following acute exercise on a motor-driven rodent treadmill, erythrocyte aggregation and deformability, erythrocyte adhesion to endothelial cells, superoxide dismutase (SOD), and glutathione peroxidase activities of the erythrocytes were analyzed. In both supplemented and non-supplemented exercised groups, there was a significant decrease in SOD activities and erythrocyte aggregation, and an increase in adhesion to endothelial cell although there was no change on erythrocyte deformability. There were no differences in the responses to the exercise of supplemented and nonsupplemented rats. The data suggested that high-dose antioxidant supplementation did not alter the effects of acute exercise on erythrocyte membrane mechanics.
Kayatekin
Berkant Muammer
BM
Dokuz Eylul University, School of Medicine, Department of Physiology, Izmir, Turkey. kayabm@deu.edu.tr
Uysal
Nazan
N
Resmi
Halil
H
Bediz
Cem Seref
CS
Temiz-Artmann
Aysegül
A
Genç
Sermin
S
Tugyan
Kazim
K
Açikgöz
Osman
O
Gönenç
Sevil
S
Akhisaroglu
Mustafa
M
Cehreli
Rüksan
R
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D018920:Coculture Techniques; D019587:Dietary Supplements; D004730:Endothelium, Vascular / Q000166:cytology / Q000201:enzymology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000378:metabolism*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D013482:Superoxide Dismutase