Memory cytolytic T-lymphocytes: induction, regulation and implications for vaccine design.
The design of vaccines that protect against intracellular infections or cancer remains a challenge. In many cases, immunity depends on the development of antigen-specific memory CD8+ T-cells that can express cytokines and kill antigen-bearing cells when they encounter the pathogen or tumor. Here, the authors review current understanding of the signals and cells that lead to memory CD8+ T-cell differentiation, the relationship between the primary CD8+ T-cell response and the memory response and the regulation of memory CD8+ T-cell survival and function. The implications of this new knowledge for vaccine design are discussed, and recent progress in the development of lipidated peptide vaccines as a promising approach for vaccination against intracellular infections and cancer is reviewed.
Baz
Adriana
A
Cooperative Research Centre for Vaccine Technology, Queensland Institute of Medical Research, Brisbane, Australia. adriana.baz@qimr.edu.au
Jackson
David C
DC
Kienzle
Norbert
N
Kelso
Anne
A
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D019496:Cancer Vaccines / Q000276:immunology* / Q000627:therapeutic use; D002454:Cell Differentiation; D049109:Cell Proliferation; D017637:Clonal Deletion; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000188:drug therapy; D008074:Lipoproteins / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D014612:Vaccines / Q000276:immunology* / Q000627:therapeutic use
D019496:Cancer Vaccines; D016207:Cytokines; D008074:Lipoproteins; D014612:Vaccines