title: Repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex affects strategic decision-making.
abstract: Although decision-making is typically seen as a rational process, emotions play a role in tasks that include unfairness. Recently, activation in the right dorsolateral prefrontal cortex during offers experienced as unfair in the Ultimatum Game was suggested to subserve goal maintenance in this task. This is restricted to correlational evidence, however, and it remains unclear whether the dorsolateral prefrontal cortex is crucial for strategic decision-making. The present study used repetitive transcranial magnetic stimulation in order to investigate the causal role of the dorsolateral prefrontal cortex in strategic decision-making in the Ultimatum Game. The results showed that repetitive transcranial magnetic stimulation over the right dorsolateral prefrontal cortex resulted in an altered decision-making strategy compared with sham stimulation. We conclude that the dorsolateral prefrontal cortex is causally implicated in strategic decision-making in healthy human study participants.
authors.affiliation: Department of Psychonomics, Helmholtz Research Institute, University of Utrecht, Utrecht, The Netherlands. M.vantWout@fss.uu.nl
authors.forename: Mascha
authors.initials: M
authors.lastname: van 't Wout
authors.forename: René S
authors.initials: RS
authors.lastname: Kahn
authors.forename: Alan G
authors.initials: AG
authors.lastname: Sanfey
authors.forename: André
authors.initials: A
authors.lastname: Aleman
mesh_terms: D000328:Adult; D003657:Decision Making / Q000502:physiology / Q000528:radiation effects*; D005260:Female; D007839:Functional Laterality / Q000528:radiation effects; D005717:Games, Experimental; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology / Q000528:radiation effects*; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D050781:Transcranial Magnetic Stimulation