title: Clinical and endoscopic features for alimentary tract cytomegalovirus disease: report of 20 cases with gastrointestinal cytomegalovirus disease.
abstract: BACKGROUND
  The clinical presentations and endoscopic features of cytomegalovirus (CMV) infection in the gastrointestinal (GI) tract are diverse, and can mimic other inflammatory gastrointestinal diseases.
  
  
  METHODS
  From 1987 to 2003 at Chang-Gung Medical Center, 20 patients with CMV infections of the GI tract who were assessed using endoscopic examinations and diagnosed via pathologic studies were retrospectively reviewed.
  
  
  RESULTS
  Most of the patients were adults with immunocompromised conditions (10/20). GI tract bleeding was the most common clinical manifestation (11/20). Five patients presented with abdominal pain, and two patients presented with diarrhea. Fifteen patients suffered from fever. The endoscopic abnormalities could be classified into four main groups: inflammatory mucosa alone (3/20), ulceration alone (7/20), inflammatory mucosa associated with ulcer (9/20) and sub-mucosal tumor with ulcer (1/20). Of the 17 patients with ulcer lesions, ten had multiple ulcers and 12 had large ulcers exceeding 2 centimeters in diameter. Of the six patients followed up with colonoscopy, one was free of disease, one had a single ulcer, and four had colitis and were CMV positive on repeat biopsy. Two patients had colon strictures with persistent CMV colitis.
  
  
  CONCLUSIONS
  Many patients with GI tract CMV infection are immunocompromised. Gastrointestinal bleeding is the most common initial presentation of gastrointestinal CMV disease. Fever is the most common associated toxic sign. Sigmoidoscopy cannot replace colonoscopy for detecting CMV colitis. The most common feature is multiple ulcers with at least one large ulcer. Endoscopic follow-up in patients with CMV colitis is recommended to investigate for possible persistent colitis and strictures.
authors.affiliation: Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taipei.
authors.forename: Wey-Ran
authors.initials: WR
authors.lastname: Lin
authors.forename: Ming-Yao
authors.initials: MY
authors.lastname: Su
authors.forename: Chen-Ming
authors.initials: CM
authors.lastname: Hsu
authors.forename: Yu-Pin
authors.initials: YP
authors.lastname: Ho
authors.forename: Kah-Wai
authors.initials: KW
authors.lastname: Ngan
authors.forename: Cheng-Tang
authors.initials: CT
authors.lastname: Chiu
authors.forename: Pang-Chi
authors.initials: PC
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005767:Gastrointestinal Diseases / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged