[Correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus squamous cell carcinoma].
OBJECTIVE
Tumor markers which relate to cell proliferation and metabolism have seldom been studied in maxillary sinus cancer. This study was conducted to identify the correlation of glutathione S-transferase pi (GST-pi) and proliferating cell nuclear antigen (PCNA) expression to prognosis of advanced maxillary sinus squamous cell carcinoma (SCC).


METHODS
The expression of GST-pi and PCNA in 54 specimens of maxillary sinus SCC, 29 specimens of benign maxillary tumor, and 20 specimens of normal nasal mucosa was detected by immunohistochemistry. The correlation of GST-pi and PCNA expression to prognosis of advanced maxillary sinus SCC was analyzed by Kaplan-Meier method. The prognosis was analyzed by Cox multivariate model.


RESULTS
The overexpression rates of GST-pi and PCNA were significantly higher in maxillary sinus SCC than in benign maxillary tumor and normal nasal mucosa (74.1% vs. 89.6% and 15.0%, P<0.01; 79.6% vs. 3.4% and 0, P<0.01). The 5-year survival rate was significantly higher in advanced maxillary sinus SCC patients with high expression of GST-pi than in the patients with low expression of GST-pi (34.5% vs. 21.2%, P=0.025); the difference between the patients with high and low expression of PCNA was not significant (18.0% vs. 27.0%, P=0.890). The expression of GST-pi was an independent prognostic factor of advanced maxillary sinus SCC (P=0.039, odds ratio>1).


CONCLUSIONS
The overexpression of GST-pi is an independent prognostic factor of advanced maxillary sinus SCC, but that of PCNA isn't.
Guo
Gui-Fang
GF
Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P. R. China. gguifang@163.com
Xie
Ru-Hua
RH
Yang
An-Kui
AK
Chen
Zhi-Hua
ZH
Wu
Qiu-Liang
QL
Liu
Wei-Wei
WW
Ou
Shen-Ming
SM
Xia
Liang-Ping
LP
Chen
Ming-Yuan
MY
Zhang
Jin-Xin
JX
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D051549:Glutathione S-Transferase pi / Q000378:metabolism*; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D016016:Proportional Hazards Models; D015996:Survival Rate
D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen; D051549:Glutathione S-Transferase pi