title: The rhythm and blues of gene expression in the rodent pineal gland.
abstract: In all vertebrates, melatonin is rhythmically synthesized in the pineal gland and functions as a hormonal message, encoding for the duration of night. In rodents, the nocturnal rise and fall of the arylalkylamine N-ace-tyltransferase (AA-NAT) activity controls the rhythmic synthesis of melatonin. This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). CREB is activated by phosphorylation, which is one of the fastest responses in pinealocytes upon adrenergic stimulation, occurring within minutes. ICER in turn accumulates only after several hours, a time gap resulting from the required de novo protein synthesis upon adrenergic stimulation. However, these molecular components of neuroendocrine signaling in the rodent pineal gland are supplemented by the impact of a variety of neurotransmitters and neuromodulators, and by translational and post-translational mechanisms. By molecular crosstalk, those different inputs on pinealocytes seem to fine-tune the shape of the melatonin signal, by interacting at various levels with the NE/cAMP/pCREB/ICER pathway. In addition, these alternate signaling routes may be important in acute "emergency" situations. Together, concerted signaling events in the rodent pineal gland help to generate a stable and reliable hormonal message of darkness for the body, that, however, can be altered rapidly upon sudden and unexpected "error" signals.
authors.affiliation: Dr. Senckenbergische Anatomie, Institute of Anatomy III, and Institute of Anatomy II, Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Karolczak
authors.forename: Horst-Werner
authors.initials: HW
authors.lastname: Korf
authors.forename: Jörg H
authors.initials: JH
authors.lastname: Stehle
mesh_terms: D000818:Animals; D005075:Biological Evolution; D015870:Gene Expression / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D008550:Melatonin / Q000096:biosynthesis* / Q000235:genetics*; D018377:Neurotransmitter Agents; D010507:Periodicity; D010870:Pineal Gland / Q000502:physiology*; D012377:Rodentia / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents; D008550:Melatonin