Mannose-binding lectin gene polymorphism and its impact on human immunodeficiency virus 1 infection.
Mannose-binding lectin (MBL) is a serum protein whose low concentration is associated with the occurrence of allele variants named MBL*B, MBL*C and MBL*D. The present study investigated the association between MBL gene polymorphism and the susceptibility to HIV-1 infection. The study of 145 HIV-1-infected subjects and 99 healthy controls showed the presence of alleles MBL*A, MBL*B and MBL*D, whose frequencies were 69%, 22% and 09% among patients and 71%, 13% and 16% among healthy controls, respectively. The presence of the variant MBL*B was associated with higher plasma viral load levels, suggesting the importance of the MBL gene polymorphism in the clinical evolution of HIV-1-infected patients.
Vallinoto
Antonio Carlos Rosário
AC
Universidade Federal do Pará, Centro de Ciências Biológicas, Departamento de Patologia, Laboratório de Virologia, 66075-900 Belém, PA, Brazil. vallinoto@ufpa.br
Menezes-Costa
Marcos Rogério
MR
Alves
Anna Elizabeth Martins
AE
Machado
Luiz Fernando Almeida
LF
de Azevedo
Vânia Nakauth
VN
Souza
Lia Lobato Batista
LL
Ishak
Marluísa de Oliveira Guimarães
Mde O
Ishak
Ricardo
R
D000483:Alleles; D001483:Base Sequence; D001938:Brazil; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D015497:HIV-1; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D011110:Polymorphism, Genetic; D014766:Viremia / Q000235:genetics / Q000276:immunology
D037601:Mannose-Binding Lectin; D004247:DNA