title: Plethysmograph and interrupter resistance measurements in prematurely born young children.
abstract: BACKGROUND
  Airways obstruction in premature infants is often assessed by plethysmography, which requires sedation. The interrupter (Rint) technique does not require sedation, but has rarely been examined in children under 2 years of age.
  
  
  OBJECTIVE
  To compare Rint results with plethysmographic measurements of airway resistance (Raw) in prematurely born, young children.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Infant and Paediatric Lung Function Laboratories.
  
  
  METHODS
  Thirty children with a median gestational age of 25-29 weeks and median postnatal age of 13 months.
  
  
  METHODS
  The infants were sedated, airway resistance was measured by total body plethysmography (Raw), and Rint measurements were made using a MicroRint device. Further Raw and Rint measurements were made after salbutamol administration if the children remained asleep.
  
  
  RESULTS
  Baseline measurements of Raw and Rint were obtained from 30 and 26 respectively of the children. Mean baseline Rint values were higher than mean baseline Raw results (3.45 v 2.84 kPa/l/s, p = 0.006). Limits of agreement for the mean difference between Rint and Raw were -1.52 to 2.74 kPa/l/s. Ten infants received salbutamol, after which the mean Rint result was 3.6 kPa/l/s and mean Raw was 3.1 kPa/l/s (limits of agreement -0.28 to 1.44 kPa/l/s).
  
  
  CONCLUSIONS
  The poor agreement between Rint and Raw results suggests that Rint measurements cannot substitute for plethysmographic measurements in sedated prematurely born infants.
authors.affiliation: Department of Child Health, 4th Floor Golden Jubilee Wing, King's College Hospital, Bessemer Road, London SE5 9RS, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Thomas
authors.forename: G F
authors.initials: GF
authors.lastname: Rafferty
authors.forename: R
authors.initials: R
authors.lastname: Blowes
authors.forename: J L
authors.initials: JL
authors.lastname: Peacock
authors.forename: N
authors.initials: N
authors.lastname: Marlow
authors.forename: S
authors.initials: S
authors.lastname: Calvert
authors.forename: A
authors.initials: A
authors.lastname: Milner
authors.forename: A
authors.initials: A
authors.lastname: Greenough
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis*; D000403:Airway Resistance / Q000502:physiology*; D000420:Albuterol; D001993:Bronchodilator Agents; D005652:Functional Residual Capacity / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D010993:Plethysmography, Whole Body / Q000379:methods* / Q000592:standards; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol