Evaluation of the effect of methadone maintenance treatment program on the frequency of DNA lesions revealed as micronuclei and sister chromatid exchanges.
The aim of the present paper was to examine the effect of substitution methadone treatment on the frequency of DNA lesions using a micronuclear and a sister chromatid exchange tests. The material under study were lymphocyte cultures from peripheral blood, collected 3 times at 3-month intervals from 24 patients. The obtained results may suggest that methadone treatment combined with a change in lifestyle significantly reduces the risk of genome lesions.
Furtak
Sylwia
S
Department of Anthropology, Institute of Zoology, Jagiellonian University, Kraków, Poland.
Pach
Dorota
D
Chrostek Maj
Jan
J
Schmager
Jan
J
D000328:Adult; D004249:DNA Damage / Q000187:drug effects*; D005260:Female; D005819:Genetic Markers / Q000187:drug effects; D006801:Humans; D008019:Life Style; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008691:Methadone / Q000494:pharmacology*; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced / Q000187:drug effects*; D008875:Middle Aged; D009294:Narcotics / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000235:genetics*; D011044:Poland; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors
D005819:Genetic Markers; D009294:Narcotics; D008691:Methadone