title: A review of controlled trials in the pharmacological treatment of premature ejaculation.
abstract: Premature ejaculation is a common sexual problem which presents to genitourinary (GU) medicine services. Five main treatment approaches have been used in clinical trials: behavioural therapy, antidepressants, phosphodiesterase-5 (PDE5) inhibitors, topical anaesthetic agents and alpha-blockers. We have carried out a systematic review of published pharmacological trials. All antidepressants appeared to delay ejaculation to some extent at all doses. Anaesthetic creams appeared to be as successful in slowing ejaculation as antidepressants without systemic side-effects, although some patients did experience erectile problems or unpleasant local symptoms. Anecdotally, behavioural therapy is effective and appears to have long-lasting efficacy. There is a need for quality comparative trial of behavioural therapy, topical anaesthetic agents and antidepressants, including appropriate measures of relapse, follow-up and acceptability of continuing long-term treatment.
authors.affiliation: Jane Wadsworth Clinic, Jefferiss Wing, St Mary's Hospital, London, UK. daniel.richardson@st-marys.nhs.uk
authors.forename: Daniel
authors.initials: D
authors.lastname: Richardson
authors.forename: John
authors.initials: J
authors.lastname: Green
authors.forename: Andrew
authors.initials: A
authors.lastname: Ritcheson
authors.forename: David
authors.initials: D
authors.lastname: Goldmeier
authors.forename: J R Willie
authors.initials: JR
authors.lastname: Harris
mesh_terms: D000317:Adrenergic alpha-Antagonists; D000929:Antidepressive Agents, Tricyclic; D018849:Controlled Clinical Trials as Topic; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D004542:Ejaculation / Q000187:drug effects*; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male
chemical_list: D000317:Adrenergic alpha-Antagonists; D000929:Antidepressive Agents, Tricyclic; D004365:Drugs, Chinese Herbal