title: Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient.
abstract: We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.
authors.affiliation: Department of Medicine I, University Clinics Heidelberg, Germany. per.humpert@med.uni-heidelberg.de
authors.forename: P M
authors.initials: PM
authors.lastname: Humpert
authors.forename: U
authors.initials: U
authors.lastname: Bärtsch
authors.forename: I
authors.initials: I
authors.lastname: Konrade
authors.forename: H-P
authors.initials: HP
authors.lastname: Hammes
authors.forename: M
authors.initials: M
authors.lastname: Morcos
authors.forename: M
authors.initials: M
authors.lastname: Kasper
authors.forename: A
authors.initials: A
authors.lastname: Bierhaus
authors.forename: P P
authors.initials: PP
authors.lastname: Nawroth
mesh_terms: D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology; D017719:Diabetic Foot / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D018919:Neovascularization, Physiologic; D020127:Recovery of Function; D014182:Transplantation, Autologous; D014945:Wound Healing