title: Impact of rapid urine antigen tests to determine the etiology of community-acquired pneumonia in adults.
abstract: OBJECTIVE
  To evaluate the rapid urine antigen tests, including a new rapid immunochromatographic test (ICT) for the detection of the Streptococcus pneumoniae antigen and an enzyme immunoassay (EIA) for the detection of the Legionella antigen, in order to improve the diagnosis of community-acquired pneumonia (CAP) in adults.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  A tertiary hospital in Spain.
  
  
  METHODS
  We consecutively recruited 107 adults with CAP evaluated at our hospital.
  
  
  METHODS
  The analyses included blood and sputum cultures, pleural fluid culture (if present) and serologic studies. The detection of the Legionella pneumophila urinary antigen was performed by EIA, and the detection of S. pneumoniae antigen in urine samples was performed by counterimmunoelectrophoresis (CIE) and a rapid ICT.
  
  
  RESULTS
  Using conventional microbiologic tests we succeeded in performing the etiologic diagnosis of 39 out of the 107 cases (36.4%). The inclusion of rapid antigen detection techniques increased the percentage of diagnosis to 54.2%, which represents a total increase of 17.8% (P=0.034).
  
  
  CONCLUSIONS
  The data obtained in this study indicate that rapid urine antigen tests are very useful to determine CAP etiology in adults and, consequently, to quickly identify a group of patients in whom narrow spectrum antibiotics may be used.
authors.affiliation: Department of Pneumology, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain. feli120@separ.es
authors.forename: Felipe
authors.initials: F
authors.lastname: Andreo
authors.forename: José
authors.initials: J
authors.lastname: Domínguez
authors.forename: Juan
authors.initials: J
authors.lastname: Ruiz
authors.forename: Silvia
authors.initials: S
authors.lastname: Blanco
authors.forename: Elisabet
authors.initials: E
authors.lastname: Arellano
authors.forename: Cristina
authors.initials: C
authors.lastname: Prat
authors.forename: Josep
authors.initials: J
authors.lastname: Morera
authors.forename: Vicente
authors.initials: V
authors.lastname: Ausina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000652:urine*; D002845:Chromatography / Q000379:methods; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000382:microbiology / Q000652:urine; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D016952:Legionella pneumophila / Q000276:immunology / Q000302:isolation & purification*; D007876:Legionellosis / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011014:Pneumonia; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis* / Q000382:microbiology / Q000652:urine; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013030:Spain; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000942:Antigens, Bacterial; D011933:Reagent Kits, Diagnostic