title: Compounds for the prevention and treatment of noise-induced hearing loss.
abstract: Noise-induced hearing loss (NIHL) is the leading occupational disease and a major contributor to the development of age-related hearing loss. The pharmacological prevention and treatment of NIHL has been under preclinical investigation for the past 20 years. Promising treatments have now been identified and entered into clinical development. Within the next five years, safe and effective drugs could be approved as the first generation of otoprotectants. This review covers strategies that are under investigation for NIHL. Drugs that effectively prevent and treat NIHL will have a significant impact on medical costs, disability compensation and several issues affecting the quality of life.
authors.affiliation: 4010 Stone Way N, Suite 120, Seattle, WA 98103, USA.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Lynch
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kil
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use; D000493:Allopurinol / Q000627:therapeutic use; D001393:Azoles / Q000627:therapeutic use; D005979:Glutathione Peroxidase / Q000627:therapeutic use; D006317:Hearing Loss, Noise-Induced / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D054833:Isoindoles; D008274:Magnesium / Q000627:therapeutic use; D009623:Noise, Occupational; D016566:Organoselenium Compounds / Q000627:therapeutic use
chemical_list: D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D000493:Allopurinol; D005979:Glutathione Peroxidase; D008274:Magnesium; D000111:Acetylcysteine