Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.
The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin).
Suresh Babu
K
K
Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
Hari Babu
T
T
Srinivas
P V
PV
Hara Kishore
K
K
Murthy
U S N
US
Rao
J Madhusudana
JM
D018926:Anti-Allergic Agents / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009025:Morpholines / Q000737:chemistry; D010936:Plant Extracts / Q000378:metabolism*; D013329:Structure-Activity Relationship
D018926:Anti-Allergic Agents; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D009025:Morpholines; D010936:Plant Extracts; C043561:chrysin; D002244:Carbon