Rosin nanoparticles as a drug delivery carrier for the controlled release of hydrocortisone.
Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167-332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery system.
Lee
Chang-Moon
CM
Interdisciplinary Program of Biomedical Engineering, Chonnam National University, 500-757, Gwangju, South Korea.
Lim
Seung
S
Kim
Gwang-Yun
GY
Kim
Dong-Woon
DW
Rhee
Joon Haeng
JH
Lee
Ki-Young
KY
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006854:Hydrocortisone / Q000008:administration & dosage*; D049329:Nanostructures; D012116:Resins, Plant
D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012116:Resins, Plant; C013893:rosin; D006854:Hydrocortisone