The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.
Suh
Young-Ger
YG
College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea. ygsuh@snu.ac.kr
Kim
Sun Nam
SN
Shin
Dong-Yun
DY
Hyun
Soon-Sil
SS
Lee
Do-Sang
DS
Min
Kyung-Hoon
KH
Han
Sae Mi
SM
Li
Funan
F
Choi
Eung-Chil
EC
Choi
Seong-Hak
SH
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D008712:Methicillin / Q000494:pharmacology; D008956:Models, Chemical; D009285:Naphthoquinones / Q000737:chemistry* / Q000378:metabolism; D011809:Quinones / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000378:metabolism; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000737:chemistry
D000890:Anti-Infective Agents; D009285:Naphthoquinones; D011809:Quinones; D012717:Sesquiterpenes; C496018:mansonone F; D014640:Vancomycin; D008712:Methicillin