Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents.
Suicidal behavior runs in families and is partially genetically determined. Since greater serotonin 5-HT(2A) receptor binding has been reported in postmortem brain and platelets of suicide victims, the 5-HT(2A) receptor gene polymorphism T102C became one of the candidate sites in the study of suicide and impulsive-aggressive traits. However, studies that examined the association of this polymorphism with suicidality have contradictory results. This study used a family-based method and one homogenous ethnic group to overcome ethnic stratification in order to test this association.


METHODS
Thirty families of inpatient adolescents from Jewish Ashkenazi origin, with a recent suicide attempt, were genotyped. All subjects were interviewed for clinical diagnosis, depressive and impulsive-aggressive traits and demographic data. Allele frequencies were assessed using the Haplotype Relative Risk method for trios.


RESULTS
No difference was found in allelic distribution between transmitted and non-transmitted alleles. There was no significant association of genotype with any of the clinical traits


CONCLUSIONS
These preliminary results suggest that the 5-HT(2A) T102C polymorphism is unlikely to be associated with suicidal behavior and related traits in adolescent suicide attempters.
Zalsman
Gil
G
Child and Adolescent Division, Geha Mental Health Center, Petach Tikva, and a Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. zalsman@neuron.cpmc.columbia.edu
Frisch
Amos
A
Baruch-Movshovits
Ruth
R
Sher
Leo
L
Michaelovsky
Elena
E
King
Robert A
RA
Fischel
Tsvi
T
Hermesh
Haggai
H
Goldberg
Pablo
P
Gorlyn
Marianne
M
Misgav
Sagit
S
Apter
Alan
A
Tyano
Sam
S
Weizman
Abraham
A
D000293:Adolescent; D000483:Alleles; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006778:Hospitals, Psychiatric; D006784:Hospitals, Teaching; D006801:Humans; D007297:Inpatients / Q000523:psychology*; D007557:Israel; D008297:Male; D011110:Polymorphism, Genetic; D000297:Psychology, Adolescent; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*
D044402:Receptor, Serotonin, 5-HT2A