[Correction of thrombocyte hemostasis and biological age reduction in metabolic syndrome].
The study shows that application of metformin, hypocaloric diet, and rational physical loads in patients with arterial hypertension (AH) with metabolic syndrome and impaired glucose tolerance (IGT), reduces pathologically hightened biological age (BA), eliminating shifts in blood lipid spectrum, moderating peroxidation syndrome, and reducing changes in thrombocyte homeostasis. Such complex therapy normalizes the adhesive and aggregation function of thrombocytes in vitro, and their intravascular activity. The parameters of the subjects had approximated the control level by the end of the 24th week of treatment. To reduce the biological age down to the level of chronological one, stabilize metabolic processes and thrombocyte homeostasis in patients with AH and IGT, the offered therapy should be prolonged and controlled.
Medvedev
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IN
Gromnatskiĭ
N I
NI
D000375:Aging / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000628:therapy*; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology