title: Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce.
abstract: Angiotensin I-converting enzyme (ACE) inhibitory peptides, Ala-Pro, Lys-Pro, and Arg-Pro, were isolated from fermented fish sauce. Five other proline-containing dipeptides having weak ACE inhibitory activity were also isolated from the fermented fish sauce. Orally administered Lys-Pro showed a tendency to lower the blood pressure of spontaneously hypertensive rats. As fermented anchovy sauce also stimulated insulin secretion by cultured RINm5F insulinoma cells, the sauce may be useful as a source of biologically active substances.
authors.affiliation: Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, AIST Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. ichimura@ni.aist.go.jp
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ichimura
authors.forename: Jianen
authors.initials: J
authors.lastname: Hu
authors.forename: Duong Qua
authors.initials: DQ
authors.lastname: Aita
authors.forename: Susumu
authors.initials: S
authors.lastname: Maruyama