Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European union BIOSAFEPAPER project.
An European Union (EU)-funded project QLK1-CT-2001-00930 (BIOSAFEPAPER) involves the development, validation and intercalibration of a short-term battery of toxicological tests for the safety assessment of food-contact paper and board. Dissemination of the results to industry, legislators (e.g. DG Consumer Protection, DG Enterprises, DG Research), standardization bodies such as CEN, and consumers will create an agreed risk evaluation procedure. The project involves pre-normative research in order to establish a set of in-vitro cytotoxicity and genotoxicity tests that will be easily adaptable to food-contact fibre-based materials and have endpoints relevant to consumer safety, including sub-lethal cellular events. These tests will be performed on samples representing actual migration conditions from food-contact paper and board with respect to different foodstuffs, and should form an experimental basis for scientifically sound recommendations for a harmonized system of risk evaluation and product testing.
Severin
I
I
Université de Bourgogne, Food Toxicology Laboratory, Campus Universitaire, 1, esplanade Erasme, F-21 000 Dijon, France.
Dahbi
L
L
Lhuguenot
J-C
JC
Andersson
M A
MA
Hoornstra
D
D
Salkinoja-Salonen
M
M
Turco
L
L
Zucco
F
F
Stammati
A
A
Dahlman
O
O
Castle
L
L
Savolainen
M
M
Weber
A
A
Honkalampi-Hämäläinen
U
U
Von Wright
A
A
D000818:Animals; D045744:Cell Line, Tumor; D002477:Cells / Q000187:drug effects; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000032:analysis / Q000633:toxicity; D004781:Environmental Exposure / Q000009:adverse effects; D000431:Ethanol / Q000032:analysis; D005062:European Union; D005504:Food Analysis / Q000379:methods; D005506:Food Contamination; D018857:Food Packaging; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008322:Mammals; D051379:Mice; D008954:Models, Biological; D009152:Mutagenicity Tests / Q000379:methods; D010209:Paper; D018570:Risk Assessment / Q000379:methods; D012449:Safety; D018675:Toxicity Tests / Q000379:methods*; D014867:Water
D014867:Water; D000431:Ethanol; D004121:Dimethyl Sulfoxide