A nuclear RNA is cut out for translation.
In this issue of Cell, Prasanth et al. (2005) provide evidence that an inosine-containing RNA that is normally retained in the nucleus is cleaved within its 3' untranslated region following cellular stress. It is then transported to the cytoplasm and translated into protein. These findings suggest that the nucleus may store RNAs destined for translation that then can be released, as needed, in response to specific cellular signals.
Bass
Brenda L
BL
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA.
Hellwig
Sabine
S
Hundley
Heather A
HA
D020121:5' Untranslated Regions; D000818:Animals; D027202:Cationic Amino Acid Transporter 2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D005786:Gene Expression Regulation; D051379:Mice; D008954:Models, Biological; D041681:NIH 3T3 Cells; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism; D015138:RNA, Nuclear / Q000235:genetics / Q000378:metabolism*
D020121:5' Untranslated Regions; D027202:Cationic Amino Acid Transporter 2; D012333:RNA, Messenger; D015138:RNA, Nuclear