title: Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy.
abstract: BACKGROUND
  In Korea, it is customary to prescribe iron and folic acid supplements to pregnant women after the 20th wk of gestation; however, little evidence exists to support this practice.
  
  
  OBJECTIVE
  The objective was to determine the effects of time of initiation and dose of prenatal iron and folic acid supplementation on the iron and folate nutriture of Korean women during pregnancy.
  
  
  METHODS
  A total of 131 pregnant women were placed into 1 of 5 experimental groups, either the control group or 1 of 4 supplemented groups. The supplemented groups varied by time of initiation, which was either during the first trimester or at week 20 of gestation, and by dose of iron and folic acid supplements provided, which consisted of either 30 mg Fe plus 175 microg folic acid or 60 mg Fe plus 350 microg folic acid. All supplemented groups continued supplementation until delivery.
  
  
  RESULTS
  Improvements in iron and folate nutriture were highly dependent on when the supplement program was initiated, but both supplement doses were equally effective. In contrast, the influence of folic acid supplementation on maternal folate status was not as pronounced as was the influence of iron supplementation on iron status.
  
  
  CONCLUSIONS
  In pregnant Korean women, initiating iron and folic acid supplementation earlier during pregnancy may prevent the deterioration of iron and folate nutriture more than does increasing supplement doses in later stages of pregnancy.
authors.affiliation: Department of Food and Nutrition, College of Human Ecology, Chonnam National University, Gwangju, Korea.
authors.forename: Jong-Im
authors.initials: JI
authors.lastname: Lee
authors.forename: Jeong-A
authors.initials: JA
authors.lastname: Lee
authors.forename: Hyeon-Sook
authors.initials: HS
authors.lastname: Lim
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018798:Anemia, Iron-Deficiency / Q000517:prevention & control*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood; D006710:Homocysteine / Q000097:blood; D006801:Humans; D019266:Iron, Dietary / Q000008:administration & dosage*; D007723:Korea; D009436:Neural Tube Defects / Q000517:prevention & control; D009751:Nutritional Requirements; D009752:Nutritional Status; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D011262:Pregnancy Trimester, Second; D039401:Prenatal Nutritional Physiological Phenomena; D013997:Time Factors
chemical_list: D019266:Iron, Dietary; D006710:Homocysteine; D005492:Folic Acid