title: COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.
abstract: Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMT(L)) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence. The 22q11.2 deletion syndrome is a promising model for identifying biomarkers related to the development of schizophrenia.
authors.affiliation: Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, 401 Quarry Road, Stanford, California 94305-5795, USA.
authors.forename: Doron
authors.initials: D
authors.lastname: Gothelf
authors.forename: Stephan
authors.initials: S
authors.lastname: Eliez
authors.forename: Tracy
authors.initials: T
authors.lastname: Thompson
authors.forename: Christine
authors.initials: C
authors.lastname: Hinard
authors.forename: Lauren
authors.initials: L
authors.lastname: Penniman
authors.forename: Carl
authors.initials: C
authors.lastname: Feinstein
authors.forename: Hower
authors.initials: H
authors.lastname: Kwon
authors.forename: Shuting
authors.initials: S
authors.lastname: Jin
authors.forename: Booil
authors.initials: B
authors.lastname: Jo
authors.forename: Stylianos E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: Michael A
authors.initials: MA
authors.lastname: Morris
authors.forename: Allan L
authors.initials: AL
authors.lastname: Reiss
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics*; D004062:DiGeorge Syndrome / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors
chemical_list: D002394:Catechol O-Methyltransferase