title: A case of elderly-onset systemic lupus erythematosus presenting as acute renal failure due to disseminated intravascular coagulation.
abstract: Herein we describe a case of a patient with elderly-onset systemic lupus erythematosus presenting as acute renal failure due to disseminated intravascular coagulation. A 78-year-old man was admitted to our hospital with fever and generalized lymphadenopathy. He was diagnosed as having systemic lupus erythematosus on the basis of renal involvement, hematological abnormality and positivity for antinuclear and anti-double-stranded DNA antibodies. Renal biopsy revealed lupus nephritis (class III and V (A/C)) with focal glomerular thrombosis. He responded to hemodialysis and corticosteroid therapy with remission of serological values and renal function. Possible mechanisms underlying the coexistence of these conditions are discussed.
authors.affiliation: Department of Nephrology, Showa University, School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. iyoda@med.showa-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Iyoda
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Hato
authors.forename: A
authors.initials: A
authors.lastname: Kuroki
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Kitazawa
authors.forename: T
authors.initials: T
authors.lastname: Sugisaki
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000368:Aged; D001706:Biopsy; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D006801:Humans; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron