title: Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis.
abstract: A case--control study was conducted to evaluate the relationship between C481T and G590A polymorphisms of arylamine-N-acetyltransferase 2 and predisposition to atopic dermatitis in children. Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects.
authors.affiliation: Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Russia. makar@soramn.ru
authors.forename: S I
authors.initials: SI
authors.lastname: Makarova
authors.forename: E M
authors.initials: EM
authors.lastname: Dodunova
authors.forename: G G
authors.initials: GG
authors.lastname: Ivanova
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: L F
authors.initials: LF
authors.lastname: Kaznacheeva
authors.forename: V V
authors.initials: VV
authors.lastname: Lyakhovich
mesh_terms: D000293:Adolescent; D000483:Alleles; D019943:Amino Acid Substitution; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000097:blood / Q000235:genetics; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000378:metabolism; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D004247:DNA; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human; D005998:Glycine