Absidia posttraumatic infection: successful treatment with posaconazole.
The class zygomycetes is a large group of filamentous fungi found ubiquitously in nature, primarily in humid soil. Their virulence in immunocompetent hosts is low; therefore, they are usually considered to be contaminants of cultures. In the present study, we describe a patient who had severe traumatic injury with an Absidia infection, who developed intolerance to antifungal treatment with amphotericin B, but responded to posaconazole treatment.
Garbino
J
J
Division of Infectious Diseases, University Hospitals of Geneva, 24, rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. jorge.garbino@hcuge.ch
Uçkay
I
I
Amini
K
K
Puppo
M
M
Richter
M
M
Lew
D
D
D020095:Absidia / Q000187:drug effects*; D000935:Antifungal Agents / Q000627:therapeutic use*; D005151:Facial Injuries / Q000150:complications*; D006801:Humans; D008297:Male; D008338:Mandibular Injuries / Q000150:complications; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology; D009917:Orbital Fractures / Q000150:complications; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole