title: Cost-effectiveness of basal flow sevoflurane anaesthesia using the Komesaroff vaporizer inside the circle system.
abstract: After ethics committee approval, 51 consenting ASA physical status 1 or 2 adult patients were given basal flow sevoflurane anaesthesia using fresh gas flows of 150 to 300 ml x min(-1) oxygen. A Komesaroff vaporizer was placed on the inspiratory limb of the circle system. Basal flows were introduced immediately following intravenous induction of anaesthesia. The vaporizer was set to deliver the maximum concentration until the inspired sevoflurane concentration (FSI) reached 3%. The dial was then adjusted to maintain the FSI at 3%. After every 60 minutes, the circuit was washed out with 100% oxygen at a flow rate of 10 l x min(-1) for one minute. The FSI reached 3% after an average of 8.5 (3.8) [mean (SD)] minutes. The trends in FSI and the expired sevoflurane concentrations were significantly different (P<0.05) between the mechanically ventilated patients (n=21) and the spontaneously ventilating patients (n =30) and demonstrated a more gradual build-up in the former group. The consumption of sevoflurane was found to be 9.2 (2.8) ml x h(-1). This represented a 52.5% cost saving over the clinical application of the Mapleson's ideal fresh gas flow sequence for low-flow anaesthesia.
authors.affiliation: Department of Anaesthesia, Gloucestershire Royal Hospital, Gloucester, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Nandalan
authors.forename: R J
authors.initials: RJ
authors.lastname: Eltringham
authors.forename: Q W
authors.initials: QW
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D000764:Anesthesia, Closed-Circuit / Q000191:economics* / Q000295:instrumentation / Q000379:methods; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000191:economics*; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000191:economics*; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane