title: [Sneddon syndrome with anti-mitochondrial type M5 antibodies].
abstract: BACKGROUND
  Antimitochondrial type M5 antibodies (AMA-M5) are among the immunological abnormalities associated with Sneddon syndrome.
  
  
  METHODS
  A 45 year-old woman, hospitalized for diplopia and with a 20-year history of obstetrical accidents, internuclear ophthalmoplegia and livedo, was diagnosed with Sneddon syndrome associated with primary antiphospholipid syndrome (APS) aggravated by the presence of AMA-M5.
  
  
  CONCLUSIONS
  AMA-M5 are immunological markers of APS to the same extent as antiphospholipid antibodies. This case demonstrates the interest of screening for AMA-M5 in cases of strong clinical suspicion of APS when the anticoagulant lupus test is normal and no anti-cardiolipin, anti-b2 glycoprotein I or antiprothrombin antibodies are found.
authors.affiliation: Unité de médecine vasculaire 10 C, Département pluridisciplinaire de médecine, CHU de Grenoble, BP 217, 38043 La Tronche Cedex. CSeinturier@chu-grenoble.fr
authors.forename: C
authors.initials: C
authors.lastname: Seinturier
authors.forename: B
authors.initials: B
authors.lastname: Imbert
authors.forename: D
authors.initials: D
authors.lastname: Ponard
authors.forename: C
authors.initials: C
authors.lastname: Drouet
authors.forename: J-L
authors.initials: JL
authors.lastname: Debru
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*; D018860:Sneddon Syndrome / Q000150:complications* / Q000175:diagnosis
chemical_list: D001323:Autoantibodies