[Effects of levonorgestrel-releasing intrauterine system on serum lipids and hepatic function].
OBJECTIVE
To assess the effect of levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and hepatic function.


METHODS
Blood samples of 35 cases receiving LNG-IUS were collected and determined for serum lipids and hepatic functions.


RESULTS
Six months after insertions, HDL-C and ApoA were increased significantly, while LDL-C and ApoB decreased significantly. TG and TC levels were decreased at the 6th months and showed significant difference till the end of one year. TG/HDL-C and LDL-C/HDL-C ratios were increased and Apo A/ApoB ratio decreased significantly. The indices of hepatic function varied in the normal ranges, while Glb were decreased significantly after one year.


CONCLUSIONS
LNG-IUS is an effective therapy without obvious adverse effect on lipid metabolism and hepatic function.
He
Shu-ming
SM
Department of Obstetrics and Gynecology, Xiaolan People's Hospital, Zhongshan 528415, China. hsm@xlrmyy.com
D000328:Adult; D005260:Female; D006801:Humans; D007436:Intrauterine Devices, Medicated / Q000009:adverse effects*; D016912:Levonorgestrel / Q000008:administration & dosage / Q000009:adverse effects*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000502:physiology*; D008111:Liver Function Tests
D008074:Lipoproteins; D016912:Levonorgestrel