Der(8)t(1;8) in myeloblastic transformation of ET with hydroxyurea as the sole prior treatment.
We described a patient with ET that evolved into MF and then subsequently developed myeloblastic transformation. A novel derivative chromosome der(8)t(1;8) was identified in the AML phase. The only prior treatment had been hydroxyurea. We hypothesized that AML in this case resulted from a complex pre-disposition by the natural progression of ET, prolonged use of HU, and the prior evolution into MF. The leukemogenic risk of HU is critically appraised.
Chim
C S
CS
University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. jcschim@hkucc.hku.hk
Ma
S K
SK
D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D013922:Thrombocytosis / Q000188:drug therapy / Q000473:pathology*; D014178:Translocation, Genetic
D006918:Hydroxyurea