title: Autologous cell based therapy for treating chronic infarct myocardium.
abstract: Recent experimental and clinical studies have shown that autologous cell based therapy using skeletal myoblasts or bone marrow-derived stem cells might have beneficial effects in chronic ischemic heart disease. The underlying concept is based on the repopulation of necrotic tissue by either readily contractile myoblasts or by bone marrow-derived stem cells. However, there is a need to resolve a number of issues for determining the better way to perform these treatments and, moreover, for assessing the real beneficial functional effect of each of these cell therapies. In this mini-review, we will discuss (i) the issues of the selection of chronic infarct animal to truly determine the impact of cell therapy on cardiac function recovery, and (ii) the evaluation of the bio-availability and the bio-distribution of transplanted cells. Some new investigational methodologies based on clinical end-points are also proposed.
authors.affiliation: Department of Cell Therapy and Tissue Engineering, UMR7563 CNRS, Faculty of Medicine-Nancy, France. Nguyen.Tran@medecine.uhp-nancy.fr
authors.forename: Nguyen
authors.initials: N
authors.lastname: Tran
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Marie
authors.forename: Joseph
authors.initials: J
authors.lastname: Nloga
authors.forename: Fatiha
authors.initials: F
authors.lastname: Mascali
authors.forename: Philippe
authors.initials: P
authors.lastname: Franken
authors.forename: Tony
authors.initials: T
authors.lastname: Lahoutte
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Laurent
authors.initials: L
authors.lastname: Antunes
authors.forename: Assia
authors.initials: A
authors.lastname: El Jaafari
authors.forename: Daniele
authors.initials: D
authors.lastname: Bensoussan
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Stoltz
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Villemot
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D002465:Cell Movement; D002908:Chronic Disease; D006801:Humans; D032448:Myoblasts, Skeletal / Q000637:transplantation; D009203:Myocardial Infarction / Q000628:therapy*; D017202:Myocardial Ischemia / Q000628:therapy; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous