title: [Principles of functioning of the complex of transcription initiation by RNA polymerase II].
abstract: This final review describes the general principle and mechanisms that underlie functioning of the machinery of transcription initiation by polymerase II in eukaryotes. The main models of transcription initiation, the module principle underlying the structure of the transcription complex, the regulation of transcription initiation, and the association between the nuclear architecture and transcription are discussed.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Shidlovskiĭ
authors.forename: D V
authors.initials: DV
authors.lastname: Kopytova
authors.forename: M M
authors.initials: MM
authors.lastname: Kurshakova
authors.forename: E N
authors.initials: EN
authors.lastname: Nabirochkina
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011401:Promoter Regions, Genetic / Q000502:physiology*; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D012319:RNA Polymerase II