title: Chemical composition and pharmacological activity of essential oil of Canarium schweinfurthii.
abstract: The essential oil obtained by hydrodistillation of the resin of Canarium schweinfurthii growing in Central African Republic, was analysed by GC and GC/MS and its analgesic and antiinflammatory effects were studied. The major constituents of the essential oil were octylacetate (60%) and nerolidol (14%). At the doses of 1, 2 and 3 ml/kg i.p. essential oil shows a significant analgesic effect using acetic acid-induced writhing and hot plate methods. However, its was unable to reduce inflammatory process in cotton pellet induced granuloma method.
authors.affiliation: CERPHAMETRA, Université de Bangui, BP1450 Bangui, République Centrafricaine, Congo. jean_koudou@yahoo.fr
authors.forename: J
authors.initials: J
authors.lastname: Koudou
authors.forename: A A
authors.initials: AA
authors.lastname: Abena
authors.forename: P
authors.initials: P
authors.lastname: Ngaissona
authors.forename: J M
authors.initials: JM
authors.lastname: Bessière
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D029403:Burseraceae / Q000737:chemistry*; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009822:Oils, Volatile