title: Human intoxication with paralytic shellfish toxins: clinical parameters and toxin analysis in plasma and urine.
abstract: This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 +/- 61.37 microg/100 gr of tissue. Data associated with clinical variables and paralytic shellfish toxins analysis in plasma and urine of the intoxicated patients are shown. For this purpose, the evolution of respiratory frequency, arterial blood pressure and heart rate of the poisoned patients were followed and recorded. The clinical treatment to reach a clinically stable condition and return to normal physiological parameters was a combination of hydration with saline solution supplemented with Dobutamine (vasoactive drug), Furosemide (diuretic) and Ranitidine (inhibitor of acid secretion). The physiological condition of patients began to improve after four hours of clinical treatment, and a stable condition was reached between 12 to 24 hours. The HPLC-FLD analysis showed only the GTX3/GTX2 epimers in the blood and urine samples. Also, these epimers were the only paralytic shellfish toxins found in the shellfish extract sample.
authors.affiliation: Laboratorio Bioquímica de Membrana. Depto. Fisología y Biofísica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: García
authors.forename: Marcelo
authors.initials: M
authors.lastname: Lagos
authors.forename: Dominique
authors.initials: D
authors.lastname: Truan
authors.forename: Karinna
authors.initials: K
authors.lastname: Lattes
authors.forename: Omar
authors.initials: O
authors.lastname: Véjar
authors.forename: Beatriz
authors.initials: B
authors.lastname: Chamorro
authors.forename: Verónica
authors.initials: V
authors.lastname: Iglesias
authors.forename: Darío
authors.initials: D
authors.lastname: Andrinolo
authors.forename: Néstor
authors.initials: N
authors.lastname: Lagos
mesh_terms: D000368:Aged; D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004232:Diuretics / Q000627:therapeutic use; D004280:Dobutamine / Q000627:therapeutic use; D005517:Foodborne Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005665:Furosemide / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008387:Marine Toxins / Q000097:blood* / Q000506:poisoning / Q000652:urine*; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use; D057096:Shellfish Poisoning; D012965:Sodium Chloride / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D004232:Diuretics; D008387:Marine Toxins; D004280:Dobutamine; D012965:Sodium Chloride; D005665:Furosemide; D011899:Ranitidine