title: Total synthesis of a diastereomer of the marine natural product clavosolide A.
abstract: The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally glycosidation.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK.
authors.forename: Conor S
authors.initials: CS
authors.lastname: Barry
authors.forename: Nick
authors.initials: N
authors.lastname: Bushby
authors.forename: Jonathan P H
authors.initials: JP
authors.lastname: Charmant
authors.forename: Jon D
authors.initials: JD
authors.lastname: Elsworth
authors.forename: John R
authors.initials: JR
authors.lastname: Harding
authors.forename: Christine L
authors.initials: CL
authors.lastname: Willis
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D019281:Dimerization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D018942:Macrolides; C455699:clavosolide A