title: Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity.
abstract: Following T-cell receptor and CD28 signaling, CD8+ T cells express a receptor for CD83, a molecule up-regulated on functionally mature dendritic cells. Although this expression pattern suggests that CD83 is involved in adaptive immunity, little is known about its function in the periphery, and the existence of its ligand on T cells is controversial. We demonstrate that the engagement of the CD83 ligand (CD83L) preferentially enriches and significantly amplifies the number of antigen-specific CD8+ T cells. Coengagement of the T-cell receptor, CD28, and CD83L supports priming of naive CD8+ T cells that retain antigen specificity and cytotoxic function for more than 6 months. Therefore, engagement of the CD83L provides a unique signal to activated CD8+ T cells that could be exploited to generate long-lived antigen-specific cytotoxic T cells for the treatment of cancer and infection.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA. naoto_hirano@dfci.harvard.edu
authors.forename: Naoto
authors.initials: N
authors.lastname: Hirano
authors.forename: Marcus O
authors.initials: MO
authors.lastname: Butler
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Xia
authors.forename: Sascha
authors.initials: S
authors.lastname: Ansén
authors.forename: Michael S
authors.initials: MS
authors.lastname: von Bergwelt-Baildon
authors.forename: Donna
authors.initials: D
authors.lastname: Neuberg
authors.forename: Gordon J
authors.initials: GJ
authors.lastname: Freeman
authors.forename: Lee M
authors.initials: LM
authors.lastname: Nadler
mesh_terms: D015703:Antigens, CD / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003001:Cloning, Molecular; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D019169:Jurkat Cells; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000276:immunology*; D000097802:CD83 Antigen
chemical_list: D015703:Antigens, CD; D018106:CD28 Antigens; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen