Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial.
We treated 34 radiation-induced superficial fibrotic lesions with pentoxifylline and vitamin E for 3 months. Mean surface area of the lesions decreased from 112 to 65 cm(2) after treatment (P<0.001). A subgroup of 21 fibrotic lesions received the medications for 6 months, in which surface area decreased from 80 to 27 cm(2) (P<0.001). Pentoxifylline-vitamin E combination improved radiation-induced fibrosis.
Haddad
Peiman
P
Radiation Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. haddad@sina.tums.ac.ir
Kalaghchi
Bita
B
Amouzegar-Hashemi
Farnaz
F
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage / Q000627:therapeutic use*; D017564:Radiation Pneumonitis / Q000188:drug therapy* / Q000209:etiology; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D011837:Radiation-Protective Agents; D014810:Vitamin E; D010431:Pentoxifylline