title: [Study of biocompatibility of polybutylcyanoacrylate nanoparticles].
abstract: OBJECTIVE
  To evaluate the biocompatibility of polybutylcyanoacrylate nanoparticles (PBCA-NP) manufactured by emulsion polymerization technique.
  
  
  METHODS
  MTT assay was performed for evaluation of the cytotoxicity of PBCA-NP (e.g. cell proliferation and hemolytic test) experiments of long-term subcutaneous implantation and implantation in the muscular tissues of PBCA-NP was conducted in rabbits to observe the inflammatory reactions due to the implantation.
  
  
  RESULTS
  No obvious cytotoxicity or hemolytic reactions were observed (with the hemolytic rate at different concentrations of PBCA-NP(5%). Three months after PBCA-NP implantation, obvious lymphocyte infiltration was not observed in the tissues around the implants which underwent gradual degradation.
  
  
  CONCLUSIONS
  PBCA-NP possesses good biocompatibility.
authors.affiliation: Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yaxx@263.net
authors.forename: Xi-xiao
authors.initials: XX
authors.lastname: Yang
authors.forename: Jan-hai
authors.initials: JH
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Guo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D004337:Drug Carriers; D004659:Enbucrilate / Q000494:pharmacology*; D005260:Female; D020007:Implants, Experimental; D008422:Materials Testing; D018482:Muscle, Skeletal / Q000601:surgery; D053758:Nanoparticles; D011090:Polyenes; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011090:Polyenes; C008952:polybutene; D004659:Enbucrilate