title: Periosteal osteosarcoma with secondary bone marrow involvement: a case report.
abstract: Periosteal osteosarcoma is an exceedingly rare type of chondroblastic osteosarcoma, showing a rather good prognosis, and secondary bone marrow involvement is unusual. However, there have been some reports describing periosteal sarcoma involving medullary bone. We encountered a patient, a 38-year-old man, who had a bone surface tumor in the left tibia. An X-ray showed an erosive cortical mass extraosseous portion, located in the diaphysis of the tibia. Other images revealed a thin cortex, periosteal reactions, coarse mineralization in the extraosseous portion, and bone marrow involvement. Grossly, surgical materials showed that the tumor mainly existed at the periosteal portion, only a part of the cortex was destroyed, and there was medullary involvement throughout. Histological examinations showed a predominantly chondroid component with malignant osteoid formation. On the basis of the histological macroscopic and microscopic findings, we made the diagnosis of periosteal osteosarcoma with secondary bone marrow involvement.
authors.affiliation: Department of Orthopedic Oncology, Tochigi Cancer Center, Utsunomiya, Tochigi, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Suehara
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yazawa
authors.forename: Kouhei
authors.initials: K
authors.lastname: Hitachi
authors.forename: Masaki
authors.initials: M
authors.lastname: Yazawa
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010521:Periosteum; D013977:Tibia