title: Evolution. Changing the cofactor diet of an enzyme.
authors.affiliation: Departments of Chemistry and Integrative Biology, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. .ellington@mail.utexas.edu
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Ellington
authors.forename: J J
authors.initials: JJ
authors.lastname: Bull
mesh_terms: D050539:3-Isopropylmalate Dehydrogenase / Q000378:metabolism*; D019943:Amino Acid Substitution; D002384:Catalysis; D019143:Evolution, Molecular; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007930:Leucine / Q000096:biosynthesis; D009154:Mutation; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D015202:Protein Engineering; D012313:RNA / Q000378:metabolism; D016337:RNA, Catalytic / Q000378:metabolism; D012641:Selection, Genetic
chemical_list: D016337:RNA, Catalytic; D009243:NAD; D009249:NADP; D012313:RNA; D007521:Isocitrate Dehydrogenase; D050539:3-Isopropylmalate Dehydrogenase; D007930:Leucine