Ganglioglioma with anaplastic recurrence of the neuronal element following radiotherapy.
Gangliogliomas are rare tumours in adults representing between 0.5% and 1% of all neuroepithelial tumours. They are of mixed cellularity comprised both of a neuronal and a glial population. Although malignant transformation is rare, and this mostly occurs in the glial element, we present a case of malignant neuroblastomatous transformation of a ganglioglioma. This is only the second ever case to our knowledge in the literature reporting the participation of the neuronal element in the malignant transformation of a ganglioglioma. In contrast with the previous published case, our patient has received post-operative therapeutic radiotherapy. The related literature is reviewed and the oncogenic role of therapeutic irradiation is discussed.
Tarnaris
Andrew
A
Department of Neurosurgery, Morriston Hospital, Swansea SA6 6NL, UK. andrewtarnaris@gmail.com
O'Brien
Ciaran
C
Redfern
Robert M
RM
D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D016371:Cranial Irradiation; D003399:Craniotomy; D005260:Female; D005500:Follow-Up Studies; D018303:Ganglioglioma / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009447:Neuroblastoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009474:Neurons / Q000473:pathology / Q000528:radiation effects; D009778:Occipital Lobe / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed