[Structure-function organization of neurokinin A and neurokinin B molecules. III. A conformational study of glycine-monosubstituted analogues of neurokinins A and B].
The conformational features of some glycine-monosubstituted analogues of neurokinins A and B were investigated by the method of theoretical conformational analysis. The calculated geometry and energy parameters permitted one to determine the structural role of each of these substituted amino acids in the mechanism of folding of the low-energy conformational states of neuropeptides. On the basis of the calculated data and the results of biological tests of these analogues, the structure-function relationships of neurokinins A and B were discussed.
Agaeva
G A
GA
Kerimli
N N
NN
Godzhaev
N M
NM
D019943:Amino Acid Substitution / Q000235:genetics; D005998:Glycine / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D015288:Neurokinin A / Q000737:chemistry* / Q000235:genetics; D015287:Neurokinin B / Q000737:chemistry* / Q000235:genetics; D017433:Protein Structure, Secondary / Q000235:genetics
D015288:Neurokinin A; D015287:Neurokinin B; D005998:Glycine