[Granular cell tumor -- a rare tumor lesion of submandibular gland origin].
BACKGROUND
Granular cell tumors are rare entities with manifestations in nearly all organ systems. Appearance in salivary glands is observed in singular cases.


METHODS
We report a 54 years old female patient with a painless submandibular tumor lesion. Using a submandibular approach the tumor was totally removed with the submandibular gland. Histologically a benign granular cell tumor was diagnosed. The immunohistological examination revealed positive for S-100 antigen and vimentin, negative for KL1 antigen. The clinical follow-up for about 3 years was without complications or tumor recidive.


CONCLUSIONS
A differential diagnosis of a submandibular mass is the rare manifestation of a benign granular cell tumor. The neurogen origin can be proven immunohistologically by positive S-100 antigen detection. The complete surgical resection is the therapy of choice.
Sartorius
C
C
Klinik für HNO-Heilkunde, Kopf- und Halschirurgie. christian_sartorius@web.de
Plechata
B
B
Luis
W
W
Kempf
H G
HG
D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D016586:Granular Cell Tumor / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D013363:Submandibular Gland / Q000473:pathology / Q000601:surgery; D013365:Submandibular Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D009418:S100 Proteins; D014746:Vimentin