Course of C-reactive protein during continuous peritoneal dialysis-associated peritonitis.
OBJECTIVE
C-reactive protein (CRP) levels increase during peritonitis. Little is known about the extent and duration of CRP elevation.


METHODS
Patients on continuous peritoneal dialysis (CPD) therapy had a baseline CRP value at the start of the study. CRP values were determined at 48 h, 2 weeks and 4 weeks after an episode of peritonitis developed in the 13 months after the study started.


RESULTS
The demographic values and comorbid diseases of the patients developing and not developing peritonitis were not significantly different. Patients who developed peritonitis had a mean +/- SD CRP value of 15.0 +/- 11.1 mg/L compared with 15.7 +/- 9.9 mg/L in patients without peritonitis. The CRP value rose to 118.35 +/- 96.86 mg/L at 48 h, and decreased to 34.5 +/- 43.6 mg/L at 2 weeks and to 30.1 +/- 39.7 mg/L at 4 weeks after the onset of peritonitis. All types of peritonitis were associated with a significant increase in CRP at 48 h. Nine patients had CRP elevations above baseline at 4 weeks; seven patients had active medical issues.


CONCLUSIONS
CRP values become significantly elevated during peritonitis. Most patients have a decrease in the CRP values toward baseline values at 4 weeks following the onset of peritonitis while 20% of patients had continued elevations. The significance of the elevations is unclear. Given the associations of CRP with cardiovascular mortality in both uremic and non-uremic patients and the association of peritonitis with mortality, the role of this inflammatory marker deserves further evaluation.
Troidle
Laura
L
New Haven CAPD, Renal Research Institute, Hospital of St Raphael and Yale University School of Medicine, New Haven, Connecticut, USA.
Kliger
Alan
A
Gorban-Brennan
Nancy
N
Finkelstein
Fredric
F
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000401:mortality; D016908:Gram-Positive Bacterial Infections / Q000276:immunology / Q000401:mortality; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000401:mortality; D010538:Peritonitis / Q000209:etiology* / Q000276:immunology* / Q000401:mortality; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein