[Neurogenesis: a novel strategy for the treatment of depression].
It is now generally accepted that the birth of new neurons occurs in brain areas such as hippocampus throughout the lifespan. The waning and waxing of neurogenesis in hippocampus is proposed as a key factor in the decent into and recovery from depression. If hippocampal neurogenesis was blocked, antidepressant would lose its behavioral effects in behavioral models of depression. Long-term, but not short-term, treatment with different classes of antidepressant could stimulate neurogenesis in the hippocampus remarkably. As the regulation of adult neurogenesis continues to be identified, it will provide novel avenues of studying the mechanism and developing pharmacological agents for depressive disorder.
Zhang
Li-Ming
LM
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850.
Li
Yun-Feng
YF
Gong
Ze-Hui
ZH
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration / Q000187:drug effects*; D009473:Neuronal Plasticity; D012701:Serotonin / Q000378:metabolism
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D012701:Serotonin