title: Risk association between human leukocyte antigen-A allele and high-risk human papillomavirus infection for cervical neoplasia in Chinese women.
abstract: To examine the association between human leukocyte antigen-A (HLA-A) allele polymorphism, human papillomavirus (HPV) infection, and risk for cervical neoplasia in Chinese women, 263 patients (155 with cervical intraepithelial neoplasia [CIN] II/III and 108 with invasive cervical cancer [ICC]) were compared with 572 controls. Overall, regardless of HPV status, a decreased risk for ICC was observed for patients with A*0207/0215N or A*2402, and an increased risk was observed for patients with A*1104. The protective association of A*0207/0215N was reproduced in HPV-16-positive patients with ICC, but not in subgroups infected with other HPV types. The risk association between A*1104 and both HPV-16 and HPV-18 was reproduced in the subgroups with CIN III/ICC. The protective association between A*2402 and HPV-16, HPV-18, HPV-52, and HPV-58 was consistently observed in all subgroups with CIN III/ICC, suggesting a linkage with a general antioncogenic genetic factor. The results of the present study indicate that HLA-A polymorphism is one of the host genetic factors that alter the risk for the development of cervical cancer in Chinese women.
authors.affiliation: Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.
authors.forename: Denise P C
authors.initials: DP
authors.lastname: Chan
authors.forename: Tak-Hong
authors.initials: TH
authors.lastname: Cheung
authors.forename: Ann O Y
authors.initials: AO
authors.lastname: Tam
authors.forename: Jo L K
authors.initials: JL
authors.lastname: Cheung
authors.forename: So-Fan
authors.initials: SF
authors.lastname: Yim
authors.forename: Keith W K
authors.initials: KW
authors.lastname: Lo
authors.forename: Nelson S S
authors.initials: NS
authors.lastname: Siu
authors.forename: Daniel X
authors.initials: DX
authors.lastname: Zhou
authors.forename: Paul K S
authors.initials: PK
authors.lastname: Chan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002681:China; D005260:Female; D015234:HLA-A Antigens / Q000145:classification / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics*; D002578:Uterine Cervical Dysplasia / Q000235:genetics*
chemical_list: D015234:HLA-A Antigens