title: Lipase-catalyzed kinetic resolution of 2,3-epoxy-1-tridecanol and its application to facile synthesis of (+)-disparlure.
abstract: Acylation of (+/-)-2,3-epoxy-1-tridecanol with acetic anhydride in diisopropyl ether by porcine pancreatic lipase yielded (2R, 3S)-2,3-epoxy-1-tridecanol as the remaining substrate with an optical purity of over 99% ee. (+)-Disparlure was synthesized in two steps from this optically active epoxy alcohol.
authors.affiliation: Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 Japan.
authors.forename: E
authors.initials: E
authors.lastname: Fukusaki
authors.forename: S
authors.initials: S
authors.lastname: Satoda
authors.forename: S
authors.initials: S
authors.lastname: Senda
authors.forename: T
authors.initials: T
authors.lastname: Omata