Infections caused by clostridium difficile in kidney or liver graft recipients.
OBJECTIVE
Antibiotic-associated diarrhea is defined as otherwise unexplained diarrhea which occurs in association with the administration of antibiotics. The incidence of this diagnosis increases worldwide due to augmentative usage of broad spectrum antibiotics. Clostridium difficile is the most common identifiable pathogen, leading to antibiotic-associated diarrhea. The aim of the article was to describe our own experience in diagnostics and treatment of infections caused by C. difficile in solid organs recipients.


METHODS
In the article, retrospective analysis of infections caused by C. difficile that occurred during first six months of 2003 in the Department of Immunology, Transplant Medicine and Internal Diseases of the Medical University of Warsaw was performed.


RESULTS
In this period 18 infections in 16 kidney or/and liver graft recipients were diagnosed. Risk factors are considered and clinical manifestation is described.


CONCLUSIONS
Proper diagnostics and therapy in this population of patients are proposed and preventive procedures are discussed.
Niemczyk
Mariusz
M
Department of Immunology, Transplant Medicine and Internal Diseases, Medical University of Warsaw, Poland. mariuszniemczyk@wp.pl
Leszczyńiski
Piotr
P
Wyzgał
Janusz
J
Paczek
Leszek
L
Krawczyk
Marek
M
Luczak
Mirosław
M
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D016360:Clostridioides difficile; D003967:Diarrhea / Q000139:chemically induced / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000382:microbiology*; D008099:Liver / Q000382:microbiology*; D016031:Liver Transplantation; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors
D000900:Anti-Bacterial Agents