title: Highly dense protein layers confirmed by atomic force microscopy and quartz crystal microbalance.
abstract: Protein adsorption on a gold surface is investigated by comparing the results of quartz crystal microbalance method and atomic force microscopy. The adsorption of streptavidin on functional gold surfaces is directly monitored by a quartz crystal microbalance, and confirmed by atomic force microscopy. For this investigation, a modified gold substrate is fabricated to obtain a topographic image of streptavidin molecules. Both methods show a correlation in terms of the highly dense protein single-layer formation, and the modified gold electrode shows a slightly denser protein layer formation because of the difference in substrate geometry as compared with that of a mica surface.
authors.affiliation: The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
authors.forename: Jongmin
authors.initials: J
authors.lastname: Kim
authors.forename: Ryujiroh
authors.initials: R
authors.lastname: Yamasaki
authors.forename: Jongwan
authors.initials: J
authors.lastname: Park
authors.forename: Hosup
authors.initials: H
authors.lastname: Jung
authors.forename: Heayeon
authors.initials: H
authors.lastname: Lee
authors.forename: Tomoji
authors.initials: T
authors.lastname: Kawai