title: The influence of cigarette smoke inhalation on bone density. A radiographic study in rats.
abstract: The aim of this study was to evaluate the influence of cigarette smoke inhalation (CSI) and its cessation on tibiae bone quality. Forty-one male Wistar rats were randomly assigned to one of the following groups: Group 1--control (n = 14), Group 2--3 months of CSI and 2 months without exposure to CSI (n = 12), and Group 3--5 months of CSI (n = 15). At the end of the experimental period, the animals were sacrificed, the tibiae removed and immediately radiographed for photodensitometric analysis. The results showed that continuous exposure to cigarette smoke promoted a significantly reduced bone density (p < 0.05) (3.22 mm Al eq +/- 0.58; 2.93 mm Al eq +/- 0.45; 1.86 mm Al eq +/- 0.35; for groups 1, 2 and 3, respectively). Similar levels of bone density were observed for the control and cessation groups (groups 1 and 2 - p > 0.05). Thus, within the limits of the present study, it can be concluded that CSI may affect tibiae bone quality, and CSI cessation results in a return towards the level of the control group.
authors.affiliation: Division of Periodontics, School of Dentistry of Piracicaba, State University of Campinas.
authors.forename: João Batista
authors.initials: JB
authors.lastname: César-Neto
authors.forename: Bruno Braga
authors.initials: BB
authors.lastname: Benatti
authors.forename: Flávio Ricardo
authors.initials: FR
authors.lastname: Manzi
authors.forename: Enilson Antônio
authors.initials: EA
authors.lastname: Sallum
authors.forename: Antônio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Francisco Humberto Junior
authors.initials: FH
authors.lastname: Nociti
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000000981:diagnostic imaging* / Q000502:physiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution