Asterosaponins from the starfish Culcita novaeguineae and their bioactivities.
Bioassay-guided fractionation of the n-BuOH extract of the starfish Culcita novaeguineae resulted in the isolation of one new sulfated steroidal glycoside (asterosaponin) (1), along with three known asterosaponins, thornasteroside A (2), marthasteroside A(1) (3) and regularoside A (4), as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. Their structures were elucidated by extensive spectral studies and chemical evidences. All the saponins showed moderate cytotoxicity against cancer cell lines K-562 and BEL-7402.
Tang
Hai-Feng
HF
Research Center for Marine Drugs, College of Pharmacy, 2nd Military Medical University, Shanghai 200433, PR China. tanghaifeng71@126.com
Yi
Yang-Hua
YH
Li
Ling
L
Sun
Peng
P
Zhang
San-Qi
SQ
Zhao
Yue-Ping
YP
D000818:Animals; D001203:Ascomycota / Q000187:drug effects; D001681:Biological Assay; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D013215:Starfish / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018675:Toxicity Tests / Q000379:methods
D012503:Saponins; D013261:Sterols; C513248:mathasteroside A1; C513250:regularoside A; C513249:thornasteroside A; C008330:marthasterone