title: Chemo-inducible gene therapy.
abstract: Chemo-inducible cancer gene therapy is a potential new treatment for solid tumors that may in part enhance the anti-tumor effects of chemotherapy while minimizing toxicity. This approach combines viral vectors expressing cytotoxic transgenes that can be transcriptionally activated by DNA-damaging agents. The development of chemo-inducible gene therapy has numerous implications for the treatment of both localized and metastatic disease in patients with solid tumors.
authors.affiliation: Department of Surgery, University of Chicago Hospitals, Chicago, Illinois 60637, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Mezhir
authors.forename: Hank
authors.initials: H
authors.lastname: Schmidt
authors.forename: Bakhtiar
authors.initials: B
authors.lastname: Yamini
authors.forename: Neil N
authors.initials: NN
authors.lastname: Senzer
authors.forename: Mitchell C
authors.initials: MC
authors.lastname: Posner
authors.forename: Donald W
authors.initials: DW
authors.lastname: Kufe
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Weichselbaum
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D051766:Early Growth Response Protein 1 / Q000235:genetics; D019450:Genes, MDR / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000628:therapy*; D011401:Promoter Regions, Genetic / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects* / Q000528:radiation effects; D048069:Tumor Necrosis Factors / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D048069:Tumor Necrosis Factors; D004247:DNA