title: Ceftriaxone versus ampicillin/cloxacillin as antibiotic prophylaxis in elective caesarean section.
abstract: We carried out a prospective, randomized, controlled clinical trial to evaluate the clinical efficacy of ceftriaxone and ampicillin/cloxacillin prophylaxis in decreasing the frequency of post-caesarean section infection-related morbidity. Two hundred patients randomly received either ceftriaxone (single dose) or ampicillin/cloxacillin (3 doses) intravenously at induction of anaesthesia. There was no statistical difference in incidence of endometritis (P = 0.34), wound infection (P = 0.44), or other febrile morbidity (P = 0.5). Eleven babies had a low Apgar score (< 8) in the ceftriaxone group and 13 in the ampicillin/cloxacillin group (P = 0.82). There were 2 perinatal deaths in each group. One dose of ceftriaxone was as effective as ampicillin/ cloxacillin in preventing post-caesarean section complications and is easier to administer.
authors.affiliation: University of Gezira, Wad Medani, Sudan.
authors.forename: E-T S
authors.initials: ET
authors.lastname: Ahmed
authors.forename: O A
authors.initials: OA
authors.lastname: Mirghani
authors.forename: A S
authors.initials: AS
authors.lastname: Gerais
authors.forename: I
authors.initials: I
authors.lastname: Adam
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001034:Apgar Score; D002443:Ceftriaxone / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects*; D003023:Cloxacillin / Q000627:therapeutic use*; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D017558:Elective Surgical Procedures / Q000009:adverse effects*; D004716:Endometritis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006784:Hospitals, Teaching; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D009017:Morbidity; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D013397:Sudan / Q000453:epidemiology; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D000667:Ampicillin; D003023:Cloxacillin