title: A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation.
abstract: Different experiential, psychophysiological, and neurobiological responses to traumatic symptom provocation in posttraumatic stress disorder (PTSD) have been reported in the literature. Two subtypes of trauma response have been hypothesized, one characterized predominantly by hyperarousal and the other primarily dissociative, each one representing unique pathways to chronic stress-related psychopathology. Recent PTSD neuroimaging findings in our own laboratory support this notion and are consistent with the view that grouping all PTSD subjects, regardless of their different symptom patterns, in the same diagnostic category may interfere with our understanding of posttrauma psychopathology. This review will integrate findings of different experiential, psychophysiological, and neurobiological responses to traumatic symptom provocation with the clinical symptomatology and the neurobiology of PTSD.
authors.affiliation: Department of Psychiatry, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, P.O. Box 5339, London, Ont., Canada N6A 5A5. ruth.lanius@lhsc.on.ca
authors.forename: R A
authors.initials: RA
authors.lastname: Lanius
authors.forename: R
authors.initials: R
authors.lastname: Bluhm
authors.forename: U
authors.initials: U
authors.lastname: Lanius
authors.forename: C
authors.initials: C
authors.lastname: Pain
mesh_terms: D001921:Brain / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis* / Q000503:physiopathology*