Miple1 and miple2 encode a family of MK/PTN homologues in Drosophila melanogaster.
Midkine (MK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. To date, this family of proteins has been implicated in multiple processes, such as growth, survival, and migration of various cells, and has roles in neurogenesis and epithelial-mesenchymal interaction during organogenesis. In this report, we have characterized two members of the MK/PTN family of proteins in Drosophila, named Miple1 and Miple2, from Midkine and Pleiotrophin. Drosophila miple1 and miple2 encode secreted proteins which are expressed in spatially restricted, nonoverlapping patterns during embryogenesis. Expression of miple1 can be found at high levels in the central nervous system, while miple2 is strongly expressed in the developing midgut endoderm. The identification of homologues of the MK/PTN family in this genetically tractable model organism should allow an analysis of their function during complex developmental processes.
Englund
Camilla
C
Umeå Center for Molecular Pathogenesis, Umeå University, Umeå, 901 87, Sweden,
Birve
Anna
A
Falileeva
Ludmilla
L
Grabbe
Caroline
C
Palmer
Ruth H
RH
D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D016207:Cytokines / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics*; D006801:Humans; D000078792:Midkine; D008969:Molecular Sequence Data; D005810:Multigene Family
D002352:Carrier Proteins; D016207:Cytokines; D029721:Drosophila Proteins; C514347:Miple1 protein, Drosophila; C514348:Miple2 protein, Drosophila; C066845:pleiotrophin; D000078792:Midkine