[Amisulpride in Huntington's disease].
OBJECTIVE
Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects.


METHODS
We report four cases of patients with clinically and genetically established Huntington's disease and signs of psychosis who were treated with Amisulpride.


RESULTS
Two patients developed extrapyramidal side effects due to the treatment. The antipsychotic therapy of all patients was effective.


CONCLUSIONS
Due to degeneration of striatal neurons patients suffering from Huntington's disease react early with development of extrapyramidal side effects after therapy with amisulpride.
Saft
Carsten
C
Neurologische Klinik der Ruhr-Universität Bochum, St. Josef-Hospital, Huntington Zentrum NRW, Bochum. carsten.saft@cityweb.de
Andrich
Jürgen
J
Kraus
Peter H
PH
Przuntek
Horst
H
D000368:Aged; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003702:Delusions / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D009483:Neuropsychological Tests; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000175:diagnosis; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride