Effect of neonatal injection of sodium glutamate and diethylnitrosamine on hepatocarcinogenesis, reproductive and adrenocortical systems of male mice.
Neonatal injection of sodium glutamate before injection of diethylnitrosamine decreased the number of tumor nodes in the liver of male mice, decreased the weight of the testes and adrenals and blood level of testosterone (but increased blood level of corticosterone), impaired recovery of diethylnitrosamine-disturbed sexual motivation in half of males. Anticarcinogenic effect of sodium glutamate is explained by feminization of males under its effect.
Kuznetsova
E G
EG
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Moscow. amst@bionet.nsc.ru
Amstislavskaya
T G
TG
Bulygina
V V
VV
Il'nitskaya
S I
SI
D000311:Adrenal Glands / Q000187:drug effects*; D000477:Alkylating Agents / Q000633:toxicity; D000818:Animals; D000831:Animals, Newborn; D004052:Diethylnitrosamine / Q000633:toxicity; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000009:adverse effects*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000009:adverse effects*; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D000477:Alkylating Agents; D005503:Food Additives; D004052:Diethylnitrosamine; D013739:Testosterone; D012970:Sodium Glutamate