Prediction and validation of microRNAs and their targets.
MicroRNAs are short non-coding RNAs that inhibit translation of target genes by binding to their mRNAs, and have been shown to play a central role in gene regulation in health and disease. Sophisticated computer-based prediction approaches of microRNAs and of their targets, and effective biological validation techniques for validating these predictions, now play a central role in discovery of microRNAs and elucidating their functions.
Bentwich
Isaac
I
Rosetta Genomics Ltd., 10 Plaut Street, Science Park, Rehovot 76706, Israel.
D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D001665:Binding Sites; D019295:Computational Biology; D017124:Conserved Sequence; D019143:Evolution, Molecular; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry* / Q000502:physiology; D046228:Microarray Analysis / Q000379:methods*; D008954:Models, Biological; D008957:Models, Genetic; D012313:RNA / Q000737:chemistry; D034622:RNA Interference; D012322:RNA Precursors; D012333:RNA, Messenger / Q000378:metabolism; D018749:RNA, Plant
D035683:MicroRNAs; D012322:RNA Precursors; D012333:RNA, Messenger; D018749:RNA, Plant; D012313:RNA