title: Bronchiectasis in persons with skin lesions resulting from arsenic in drinking water.
abstract: BACKGROUND
  Arsenic is a unique human carcinogen in that it causes lung cancer by exposure through ingestion (in drinking water) as well as through inhalation. Less is known about nonmalignant pulmonary disease after exposure to arsenic in drinking water.
  
  
  METHODS
  We recruited 108 subjects with arsenic-caused skin lesions and 150 subjects without lesions from a population survey of over 7000 people in an arsenic-exposed region in West Bengal, India. Thirty-eight study participants who reported at least 2 years of chronic cough underwent high-resolution computed tomography (CT); these scans were read by investigators in India and the United States without knowledge of the presence or absence of skin lesions.
  
  
  RESULTS
  The mean (+/-standard deviation) bronchiectasis severity score was 3.4 (+/-3.6) in the 27 participants with skin lesions and 0.9 (+/-1.6) in the 11 participants without these lesions. In subjects who reported chronic cough, CT evidence of bronchiectasis was found in 18 (67%) participants with skin lesions and 3 (27%) subjects without skin lesions. Overall, subjects with arsenic-caused skin lesions had a 10-fold increased prevalence of bronchiectasis compared with subjects who did not have skin lesions (adjusted odds ratio=10; 95% confidence interval=2.7-37).
  
  
  CONCLUSIONS
  These results suggest that, in addition to being a cause of lung cancer, ingestion of high concentrations of arsenic in drinking water may be a cause of bronchiectasis.
authors.affiliation: Institute of Post Graduate Medical Education and Research, Kolkata, India.
authors.forename: D N Guha
authors.initials: DN
authors.lastname: Mazumder
authors.forename: Craig
authors.initials: C
authors.lastname: Steinmaus
authors.forename: Partha
authors.initials: P
authors.lastname: Bhattacharya
authors.forename: Ondine S
authors.initials: OS
authors.lastname: von Ehrenstein
authors.forename: Nilima
authors.initials: N
authors.lastname: Ghosh
authors.forename: Michael
authors.initials: M
authors.lastname: Gotway
authors.forename: Arabinda
authors.initials: A
authors.lastname: Sil
authors.forename: John R
authors.initials: JR
authors.lastname: Balmes
authors.forename: Reina
authors.initials: R
authors.lastname: Haque
authors.forename: Meera M
authors.initials: MM
authors.lastname: Hira-Smith
authors.forename: Allan H
authors.initials: AH
authors.lastname: Smith
mesh_terms: D000328:Adult; D020261:Arsenic Poisoning / Q000453:epidemiology*; D001987:Bronchiectasis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000453:epidemiology; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000139:chemically induced* / Q000453:epidemiology; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D014881:Water Supply / Q000032:analysis*