title: Enantiomerically pure 2-bromo-2'-diphenylphosphinyl-1,1'- binaphthyl as a monophosphorus template for electrophilic functionalization in chiral MOP-type ligand synthesis.
abstract: [reaction: see text] Pd-catalyzed monophosphinylation of (R)-2-bromo-2'-iodo-1,1'-binaphthyl with Ph(2)P(O)H afforded (R)-2-bromo-2'-diphenylphosphinyl-1,1'-binaphthyl in good yield with excellent chemoselectivity and no observable racemization. Subsequent lithiation in the presence of excess thiosulfonate furnished an enantiomerically pure sulfenylation product, which was reduced to afford a chiral S-MOP ligand.
authors.affiliation: Faculty of Engineering, Niigata University, Ikarashi, Japan. hoshi@gs.niigata-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Hoshi
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Hagiwara