title: Obstetric complications in Marfan syndrome.
abstract: OBJECTIVE
  To investigate the obstetric maternal and neonatal outcome of pregnancy in women with Marfan syndrome.
  
  
  METHODS
  Retrospective observational multi-center study based on congenital heart disease registry.
  
  
  RESULTS
  Sixty-three of the 122 enrolled women with Marfan syndrome had been pregnant 142 times (including 111 pregnancies>20 weeks, 28 (20%) miscarriages and 3 elective abortions). In 40% of all completed pregnancies an obstetric and/ or neonatal complication occurred. The most important complications were an increased percentage of premature deliveries (n=17, 15%) mainly due to preterm premature rupture of membranes and cervical incompetence and a markedly increased combined fetal and neonatal mortality of 7.1%. An obstetric and/or neonatal complication occurred in a similar proportion of pregnancies in women with a diagnosis of Marfan syndrome before pregnancy versus women with a diagnosis of Marfan syndrome after pregnancy (39% vs. 41%, p=0.85, respectively).
  
  
  CONCLUSIONS
  In addition to cardiovascular complications, pregnancy in women with Marfan syndrome is associated with a high rate of premature deliveries, preterm premature rupture of membranes and increased mortality in the offspring.
authors.affiliation: Department of Cardiology, Rm B2-240, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, and Department of Cardiology, Radboud Hospital Nijmegen, The Netherlands.
authors.forename: Lilian J
authors.initials: LJ
authors.lastname: Meijboom
authors.forename: Willem
authors.initials: W
authors.lastname: Drenthen
authors.forename: Petronella G
authors.initials: PG
authors.lastname: Pieper
authors.forename: Maarten
authors.initials: M
authors.lastname: Groenink
authors.forename: Joris A M
authors.initials: JA
authors.lastname: van der Post
authors.forename: Janneke
authors.initials: J
authors.lastname: Timmermans
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Voors
authors.forename: Jolien W
authors.initials: JW
authors.lastname: Roos-Hesselink
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: van Veldhuisen
authors.forename: Barbara J M
authors.initials: BJ
authors.lastname: Mulder
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D000368:Aged; D005260:Female; D005865:Gestational Age; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal