title: Diagnosis and management of adult onset Still's disease.
abstract: BACKGROUND
  Adult onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown aetiology that is responsible for a significant proportion of cases of fever of unknown origin and can also have serious musculoskeletal sequelae.
  
  
  OBJECTIVE
  To assess and synthesise the evidence for optimal diagnosis and management of AOSD.
  
  
  METHODS
  The key terms, adult onset Still's disease, AOSD, adult Still's disease, ASD, Still's disease were used to search Medline (1966-2005) and PubMed (1966-2005) for all available articles in the English language. Clinically relevant articles were subsequently selected. Bibliographies, textbooks, and websites of recent rheumatology conferences were also assessed.
  
  
  RESULTS
  Data on diagnosis and treatment of AOSD are limited in the medical literature and consist mainly of case reports, small series, and modest scale retrospective studies. Diagnosis is clinical and requires exclusion of infectious, neoplastic, and other autoimmune diseases. Laboratory tests are non-specific and reflect heightened immunological activity. Treatment comprises non-steroidal anti-inflammatory drugs, corticosteroids, immunosuppressive drugs (methotrexate, leflunomide, gold, azathioprine, cyclosporin A, cyclophosphamide), and intravenous gammaglobulin. The recent successful application of biological agents (anti-tumour necrosis factor, anti-interleukin (IL)1, anti-IL6), often in combination with traditional immunosuppressive drugs, has been very promising.
  
  
  CONCLUSIONS
  AOSD often poses a diagnostic and therapeutic challenge and clinical guidelines are lacking. The emergence of validated diagnostic criteria, discovery of better serological markers, and the application of new biological agents may all provide the clinician with significant tools for the diagnosis and management of this complex systemic disorder.
authors.affiliation: Department of Medicine, New Jersey Medical School, UMDNJ, Newark, NJ 07101, USA. efthimpv@umdnj.edu
authors.forename: P
authors.initials: P
authors.lastname: Efthimiou
authors.forename: P K
authors.initials: PK
authors.lastname: Paik
authors.forename: L
authors.initials: L
authors.lastname: Bielory
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D018501:Antirheumatic Agents