title: Protection of tilapia (Oreochromis mosambicus) from edwardsiellosis by vaccination with Edwardsiella tarda ghosts.
abstract: The vaccine potential of Edwardsiella tarda ghosts produced by gene E mediated lysis was investigated using tilapia (Oreochromis mosambicus). Tilapia immunized with E. tarda ghosts (ETG) and formalin killed E. tarda (FKC) vaccines showed significantly higher serum agglutination titers than control fish. Fish immunized with ETG showed no significant differences with fish immunized with FKC in serum agglutination titers, but showed significantly higher bactericidal activity than fish immunized with FKC. Furthermore, fish immunized with ETG showed higher protection than fish immunized with FKC. As this promising type of a non-living whole cell envelope preparation seems to be favorable over conventional vaccines, we suggest E. tarda ghosts as a new vaccine candidate.
authors.affiliation: Department of Aquatic Life Medicine, Pukyong National University, Pusan 608-737, Republic of Korea.
authors.forename: Se Ryun
authors.initials: SR
authors.lastname: Kwon
authors.forename: Yoon Kwon
authors.initials: YK
authors.lastname: Nam
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Kim
authors.forename: Ki Hong
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D020609:Edwardsiella tarda / Q000166:cytology / Q000276:immunology*; D004756:Enterobacteriaceae Infections / Q000517:prevention & control / Q000662:veterinary*; D005393:Fish Diseases / Q000382:microbiology* / Q000517:prevention & control*; D017210:Tilapia; D013997:Time Factors; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D015164:Vaccines, Inactivated / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; C029555:E protein, bacteriophage X174; D015164:Vaccines, Inactivated; D014764:Viral Proteins