title: Rosin nanoparticles as a drug delivery carrier for the controlled release of hydrocortisone.
abstract: Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167-332 nm diam. The drug was loaded approximately 50% of initial feeding amount in all formulation. Release of hydrocortisone from the nanoparticles in vitro gradually decreased with increasing initial rosin content at pH 7.4. HC was also released very slowly at pH 1.2. Nanoparticles based on rosin thus are potentially useful as a drug delivery system.
authors.affiliation: Interdisciplinary Program of Biomedical Engineering, Chonnam National University, 500-757, Gwangju, South Korea.
authors.forename: Chang-Moon
authors.initials: CM
authors.lastname: Lee
authors.forename: Seung
authors.initials: S
authors.lastname: Lim
authors.forename: Gwang-Yun
authors.initials: GY
authors.lastname: Kim
authors.forename: Dong-Woon
authors.initials: DW
authors.lastname: Kim
authors.forename: Joon Haeng
authors.initials: JH
authors.lastname: Rhee
authors.forename: Ki-Young
authors.initials: KY
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006854:Hydrocortisone / Q000008:administration & dosage*; D049329:Nanostructures; D012116:Resins, Plant
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012116:Resins, Plant; C013893:rosin; D006854:Hydrocortisone