Biologic transplantation and neurotrophin-induced neuroplasticity after traumatic brain injury.
OBJECTIVE
In this review, we analyze progress in the treatment of traumatic brain injury with neurotrophins, growth factors and cell and tissue neurotransplantation. The primary objective of these therapies is to reduce neurologic deficits associated with the trauma by inducing neuroplasticity. These therapies are restorative and not necessarily neuroprotective.


METHODS
An extensive literature on administration of neurotrophics factors and cell and tissue cerebral transplantation is reviewed. The effects of these therapeutic approaches on brain biochemical, molecular, cellular, and tissue responses are summarized.


CONCLUSIONS
The cumulative data indicate that cell therapy shows substantial promise in the treatment of neural injury.
Lu
Dunyue
D
Department of Neurosurgery, Henry Ford Health System, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
Mahmood
Asim
A
Chopp
Michael
M
D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D009414:Nerve Growth Factors / Q000627:therapeutic use*; D009417:Nerve Tissue / Q000637:transplantation*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000637:transplantation*; D018377:Neurotransmitter Agents / Q000378:metabolism; D020127:Recovery of Function
D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents