Visual loss as a first sign of adult-type chronic myeloid leukemia in a child.
OBJECTIVE
To report the unusual case of retinal leukemic infiltration in a child with adult-type chronic myelocytic leukemia.


METHODS
Interventional case report.


METHODS
Complete ophthalmologic examination, including visual acuity measurement and funduscopy. The diagnosis was established by blood cell counts and confirmed by a positive Philadelphia-chromosome translocation (t [9,22]). Treatment consisted of hydroxyurea and stem-cell transplantation.


RESULTS
After therapy, complete regression of the retinal lesion was observed with full recovery of visual acuity.


CONCLUSIONS
This case underlines the importance of interdisciplinary cooperation between ophthalmologists and pediatric oncologists in the diagnosis and treatment of this disease.
Rudolph
Günther
G
Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany. guenther.rudolph@med.uni-muenchen.de
Haritoglou
Christos
C
Schmid
Irene
I
Hochhaus
Friedericke
F
Kampik
Anselm
A
D001766:Blindness / Q000175:diagnosis* / Q000628:therapy; D001772:Blood Cell Count; D002648:Child; D005451:Fluorescein Angiography; D018380:Hematopoietic Stem Cell Transplantation; D006529:Hepatomegaly; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000628:therapy; D007964:Leukocytosis / Q000175:diagnosis; D008297:Male; D010677:Philadelphia Chromosome; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D013163:Splenomegaly; D014178:Translocation, Genetic; D014792:Visual Acuity
D006918:Hydroxyurea