Role of lipooligosaccharide in the attachment of Moraxella catarrhalis to human pharyngeal epithelial cells.
The goal of this study was to determine the role of lipooligosaccharide in the attachment of Moraxella catarrhalis to human pharyngeal epithelial cells. Strain 2951 and its P(k) mutant strain 2951 galE were used in this study. This study suggests that the P(k) epitope of LOS is not an adhesin for M. catarrhalis, but plays a crucial role by its surface charge in the initial stage of attachment.
Akgul
Gulcan
G
Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.
Erturk
Ali
A
Turkoz
Mustafa
M
Turan
Tolga
T
Ichinose
Akitoyo
A
Nagatake
Tsuyoshi
T
Ahmed
Kamruddin
K
D018829:Adhesins, Bacterial / Q000502:physiology*; D001422:Bacterial Adhesion / Q000502:physiology*; D002460:Cell Line; D004847:Epithelial Cells / Q000382:microbiology*; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism*; D001936:Moraxella catarrhalis / Q000472:pathogenicity* / Q000502:physiology; D010614:Pharynx / Q000166:cytology / Q000382:microbiology*; D011135:Polysaccharides, Bacterial / Q000502:physiology*
D018829:Adhesins, Bacterial; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; C055239:bacterial adhesins, polysaccharide; C023023:lipid-linked oligosaccharides