title: Ischaemic cholangiopathy and sickle cell disease.
abstract: We report a case of a 6-year-old girl of Afro-Caribbean origin, known to have sickle cell disease (SCD), with recurrent history of jaundice and abdominal pain. She was extensively investigated, including endoscopic retrograde cholangiopancreatography (ERCP), which revealed diffuse cholangiopathy of both extrahepatic and intrahepatic bile ducts. A pigtail stent was placed and balloon dilatation was performed for stricture of the extrahepatic duct. Since then, she remains well and asymptomatic. We suggest that cholangiopathy is the consequence of sickling in the end arteries of the biliary arterial tree.
authors.affiliation: Institute of Liver Studies, King' College Hospital, Denmark Hill, London, UK.
authors.forename: Mansoor
authors.initials: M
authors.lastname: Ahmed
authors.forename: Moira
authors.initials: M
authors.lastname: Dick
authors.forename: Giorgina
authors.initials: G
authors.lastname: Mieli-Vergani
authors.forename: Phil
authors.initials: P
authors.lastname: Harrison
authors.forename: John
authors.initials: J
authors.lastname: Karani
authors.forename: Anil
authors.initials: A
authors.lastname: Dhawan
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D017734:Bile Ducts, Extrahepatic / Q000098:blood supply*; D002404:Catheterization; D002648:Child; D002779:Cholestasis / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000628:therapy; D015607:Stents