[Analgesic actions after local peripheral administration of Lornoxicam in a model of formalin test in the rat].
OBJECTIVE
To investigate analgesic actions after local peripheral administration of Lornoxicam in an animal model of formalin test.


METHODS
Male Spague-Dawley rats were randomly divided into 3 groups, namely the control, the ipsilateral and the contralateral groups. Each group consisted of 8 rats. Thirty minutes prior to subcutaneous injections of 20 g/L formalin 50 microl into the plantar surface of the right hind-paw, the rats of ipsilateral group received Lornoxicam in the plantar surface of the right hind-paw, and the rats of contralateral group received Lornoxicam in the contralateral plantar surface of the hindpaw. Pain response was recorded for a period of 60 minutes. The summation of time (in seconds) spent in licking and biting responses to the injected paw during each 5 minutes block was analyzed for comparison.


RESULTS
The pain response in the first phase (from 0 to 10 minutes) was not inhibited (P > 0.05). The pain response in the second phase (from 10 to 60 minutes) was inhibited in the ipsilateral group (P < 0.05).


CONCLUSIONS
Local peripheral administration of Lornoxicam has analgesic effect on the rat's planta in the second phase of a formalin test model; the mechanism involved is mainly local, but not systemic.
Li
Guo-Yan
GY
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yang
Bang-Xiang
BX
Liu
Hui
H
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D005557:Formaldehyde; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement / Q000187:drug effects*; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D005557:Formaldehyde; C059451:lornoxicam