Selective regulation of cellular processes via protein cascades acting as band-pass filters for time-limited oscillations.
We show by mathematical modelling that a two-level protein cascade can act as a band-pass filter for time-limited oscillations. The band-pass filters are then combined into a network of three-level signalling cascades that by filtering the frequency of time-limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time-limited calcium oscillations.
Marhl
Marko
M
Department of Physics, Faculty of Education, University of Maribor, Slovenia. marko.marhl@uni-mb.si
Perc
Matjaz
M
Schuster
Stefan
S
D020013:Calcium Signaling / Q000502:physiology*; D003198:Computer Simulation; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D013997:Time Factors
D011506:Proteins