Notch signaling is an important regulator of type 2 immunity.
Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4+ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.
Tu
Lili
L
Department of Pathology and Laboratory Medicine, School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Fang
Terry C
TC
Artis
David
D
Shestova
Olga
O
Pross
Seth E
SE
Maillard
Ivan
I
Pear
Warren S
WS
D000818:Animals; D015139:Blotting, Southern; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D017931:DNA Primers; D005434:Flow Cytometry; D049452:Green Fluorescent Proteins; D007111:Immunity, Cellular / Q000276:immunology*; D007891:Leishmania / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D018418:Th2 Cells / Q000378:metabolism*; D014258:Trichuris / Q000276:immunology
D017931:DNA Primers; D051880:Receptors, Notch; D049452:Green Fluorescent Proteins