title: Evidence for progressive gray matter loss in patients with relapsing-remitting MS.
abstract: Little is known about the temporal evolution of gray matter damage occurring early in the course of multiple sclerosis (MS). The authors investigated the evolution of gray matter volume loss in 117 patients with relapsing-remitting MS, scanned monthly for a 9-month period. Time-trend analysis revealed a decrease of gray matter volumes over the study period (p < 0.001). This study shows that gray matter damage in relapsing-remitting MS evolves markedly over a short period of observation.
authors.affiliation: Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Valsasina
authors.forename: B
authors.initials: B
authors.lastname: Benedetti
authors.forename: M
authors.initials: M
authors.lastname: Rovaris
authors.forename: M P
authors.initials: MP
authors.lastname: Sormani
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D001284:Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis* / Q000503:physiopathology; D009410:Nerve Degeneration / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D011237:Predictive Value of Tests