title: Enzymatic functionalization of aromatic N-heterocycles: hydroxylation and carboxylation.
abstract: Aromatic N-heterocycles are common structural motifs and versatile building blocks for the synthesis of various biologically active compounds. The application of microbial catalysis is considerably advantageous for the synthesis of N-heterocycle derivatives. Recent progress in the microbial functionalization of aromatic N-heterocyclic compounds is reviewed, focusing on the regiospecific hydroxylation and the carboxylation of aromatic N-heterocycles.
authors.affiliation: Department of Biomolecular Science, Gifu University, 1-1 Yanagido, Gifu 631-1193, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa