Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats.
Administration of simvastatin (80 mg/kg, po. evening dose) and gemfibrozil (600 mg/kg, po twice) for 30 days produced significant decrease in the level of reduced glutathione, superoxide dismutase, catalase and increase in the level of lipid peroxidation and various serum parameters (creatine phosphokinase, lactate dehydrogenase, serum glutamate oxaloacetate transaminase, creatinine, urea and blood urea nitrogen). This suggested involvement of oxidative stress in rhabdomyolysis. Increase in the level of reduced glutathione, superoxide dismutase, catalase and decrease in the level of lipid peroxidation and serum parameters after administration of antioxidant CoQ10 (10 mg/kg.ip) proved the protective effect of CoQ10 in rhabdomyolysis.
Farswan
Mamta
M
Department of Pharmacy, Faculty of Technology and Engineering, M.S. University of Baroda, Baroda 390 001, India. mamta_fr2002@yahoo.co.in
Rathod
S P
SP
Upaganlawar
A B
AB
Semwal
Arvind
A
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000097:blood; D003067:Coenzymes; D003404:Creatinine / Q000097:blood; D005260:Female; D015248:Gemfibrozil / Q000009:adverse effects*; D005978:Glutathione / Q000097:blood; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects; D015227:Lipid Peroxidation; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000097:blood* / Q000139:chemically induced*; D019821:Simvastatin / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D000975:Antioxidants; D003067:Coenzymes; D000960:Hypolipidemic Agents; D016877:Oxidants; D014451:Ubiquinone; D019821:Simvastatin; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; C024989:coenzyme Q10; D005978:Glutathione; D015248:Gemfibrozil