Phage display tools for blood typing.
Current technologies used in blood banks for blood group antigen typing and other pretransfusion tests are extraordinarily labor-intensive, prone to human error, and an order of magnitude more expensive per test than those in other clinical laboratories. With a growing shortage of skilled medical technologists, dwindling supplies of human plasma-derived phenotyping reagents, and an inherent difficulty in fully automating agglutination-based methodologies, the ability to perform rapid and accurate pretransfusion testing in a cost-effective manner has become a significant challenge. This paper reviews the latest advances in the use of phage display technologies to address these issues through the development of inexpensive and renewable blood bank testing reagents that are amenable to high-throughput, automatable assay systems.
Siegel
Don L
DL
Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. siegeld@mail.med.upenn.edu
D001788:Blood Grouping and Crossmatching / Q000379:methods*; D006801:Humans; D019151:Peptide Library
D019151:Peptide Library