title: The effect of Helicobacter pylori on insulin resistance.
abstract: Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylorihas been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. Sixty-three patients were enrolled in the study. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73+/- 1.1 in the H. pylori-negative group, whereas it was 2.56 +/- 1.54 in the H. pylori-positive group (P < 0.05). This study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance.
authors.affiliation: Department of Gastroenterology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey. selimaydemir@hotmail.com
authors.forename: Selim
authors.initials: S
authors.lastname: Aydemir
authors.forename: Taner
authors.initials: T
authors.lastname: Bayraktaroglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sert
authors.forename: Coskun
authors.initials: C
authors.lastname: Sokmen
authors.forename: Hulusi
authors.initials: H
authors.lastname: Atmaca
authors.forename: Gorkem
authors.initials: G
authors.lastname: Mungan
authors.forename: Banu Dogan
authors.initials: BD
authors.lastname: Gun
authors.forename: Ali
authors.initials: A
authors.lastname: Borazan
authors.forename: Yucel
authors.initials: Y
authors.lastname: Ustundag
mesh_terms: D000328:Adult; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged