[Morphological changes in experimental melanoma B-16 effected by a conjugate of polyvinylpyrrolidone and metal-organic complex of copper and melphalan].
Data on morphological alterations in experimental melanoma B-16 induced by conjugate of polyvinylpyrrolidone and metal-organic complex of copper and melfalon are presented. The antitumor effect of the synthetic conjugate, which inhibits melanoma-16 growth, is adequately tolerated by bone marrow cells. Conjugate accumulation among the dividing cells inhibits the proliferatrive capability of malignant cells and causes other specific morphological changes to occur. It was found that polyvinylpyrrolidone conjugate can be used as a carrier whenever there is a problem of making certain drugs soluble and, thus, more marketable.
Abduvaliev
A A
AA
Gil'dieva
M S
MS
Tamarskiĭ
V P
VP
Muratkhodzhaev
N K
NK
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003300:Copper / Q000008:administration & dosage*; D005260:Female; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology*; D008558:Melphalan / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D009942:Organometallic Compounds / Q000008:administration & dosage*; D011205:Povidone / Q000008:administration & dosage*
D018906:Antineoplastic Agents, Alkylating; D009942:Organometallic Compounds; D003300:Copper; D011205:Povidone; D008558:Melphalan