title: Mechanisms of cytotoxicity of selected organogold(III) compounds.
abstract: The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
authors.affiliation: Department of Pharmacology and Chemistry, University of Florence, Florence, Italy, Department of Chemistry, University of Sassari, Sassari, Italy. marcella.coronnello@unifi.it
authors.forename: Marcella
authors.initials: M
authors.lastname: Coronnello
authors.forename: Enrico
authors.initials: E
authors.lastname: Mini
authors.forename: Barbara
authors.initials: B
authors.lastname: Caciagli
authors.forename: Maria Agostina
authors.initials: MA
authors.lastname: Cinellu
authors.forename: Alberto
authors.initials: A
authors.lastname: Bindoli
authors.forename: Chiara
authors.initials: C
authors.lastname: Gabbiani
authors.forename: Luigi
authors.initials: L
authors.lastname: Messori
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D050607:Organogold Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C505986:(6-(1,1-dimethylbenzyl)-2,2'-bipyridine)(2,6-xylidine)gold(III); D000970:Antineoplastic Agents; D050607:Organogold Compounds; C505987:diacetato(2-(1,1-dimethylbenzyl)pyridine)gold(III)