[Expression of corticotropin-releasing hormone and its receptor type-1 in the placental cotyledon vessels].
OBJECTIVE
To study the expression of corticotropin-releasing hormone(CRH) and its receptor type-1 in the placental cotyledon vessels at term.


METHODS
IHC-SP staining and ISH methods were used to investigate the expression patterns of CRH and its receptor CRH-R1 in the placental cotyledon vessels at term from women who had undergone uncomplicated pregnancies. Placental tissues were collected after cesarian section before threatened labor.


RESULTS
This study revealed for the first time that endothelial cells and even smooth muscle cells of the cotyledon vessel expressed CRH messenger ribonucleic acid and peptide as well as the CRH-R1.


CONCLUSIONS
The novel findings disclosed that the CRH derived from endothelial cells and even smooth muscle cells of the cotyledon vessel may represent the main source of CRH levels in fetal plasma, thus indicating the capability of mobilizing the compensation mechanism for adapting to the acute stress.
Wang
Xiao-Dong
XD
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Yu
Hai-Yan
HY
Yao
Qiang
Q
Liu
Shu-Yun
SY
D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D005311:Fetal Hypoxia; D006801:Humans; D010920:Placenta / Q000098:blood supply* / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D018019:Receptors, Corticotropin-Releasing Hormone / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D018019:Receptors, Corticotropin-Releasing Hormone; D003346:Corticotropin-Releasing Hormone