[Environmental risk factors and outdoor formaldehyde and risk of congenital heart malformations].
The aim of the study was to assess the relationships between environmental risk factors and the risk of congenital heart malformations.


METHODS
An epidemiological case-control study was conducted. We investigated the effect of 43 potential risk factors for congenital heart malformations and calculated their crude and adjusted odds ratios.


RESULTS
The analysis revealed that maternal age at delivery (< 19 or > or = 35 years), marital status, chronic diseases, reproductive history, maternal and paternal smoking, occupational and residential hazards were associated with increased risk of congenital heart malformations. Residential exposure to ambient formaldehyde (>2.42 microg/m3) tended to increase the risk of congenital heart malformations by 24% (OR=1.24; 95% CI 0.81-2.07).


CONCLUSIONS
Stratified analysis of effects of exposure to occupational and residential hazards together showed that the risk of congenital heart malformations has increased significantly.
Dulskiene
Virginija
V
Institute of Cardiology, Kaunas University of Medicine, Sukileliu 17, 50161 Kaunas, Lithuania. vdulskiene@med.kmu.lt
Grazuleviciene
Regina
R
D000033:Abortion, Threatened; D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D000428:Alcohol Drinking / Q000009:adverse effects; D005220:Fathers; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008423:Maternal Age; D009035:Mothers; D016017:Odds Ratio; D011247:Pregnancy; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D012959:Socioeconomic Factors; D013315:Stress, Psychological / Q000150:complications
D000393:Air Pollutants; D005557:Formaldehyde