[Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene].
OBJECTIVE
To identify polymorphisms of the serotonin transporter(5-HTT) gene and to find out whether there was relationship between any such polymorphisms and sleep apnea syndrome (SAS).


METHODS
For two polymorphisms of 5-HTT target DNA gene was amplified using polymerase chain reaction (PCR) and 6% non-denaturing polyacrylamide gels electrophoresis. The frequencies of the different forms of the genotypes and alleles of 5-HTT gene were analyzed in 104 patients with SAS and 150 healthy controls.


RESULTS
The frequencies of the S or L alleles and the S/S, S/L or L/L genotypes in promoter region of 5-HTT gene in SAS group were not significantly different to those in healthy controls (P > 0.05). However, the frequencies of 10/10, 12/10 genotypes of 5-HTT-VNTR in SAS patients were significantly higher than those in healthy control subjects (P < 0.05). Moreover, the frequency of the allele 10 of 5-HTT-VNTR in SAS patients was significantly higher than that in healthy controls (P<0.01).


CONCLUSIONS
The allele 10 of 5-HTT-VNTR might be a susceptible factor in the pathogenesis of SAS.
Yue
Wei-hua
WH
Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
Liu
Po-zi
PZ
Hao
Wei
W
Zhang
Xiang-hui
XH
Wang
Xiao-ping
XP
Zhang
Ji-shui
JS
Zhou
Xu-hui
XH
Xie
Yong-biao
YB
Ni
Ming
M
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012891:Sleep Apnea Syndromes / Q000235:genetics*; D055815:Young Adult
D050486:Serotonin Plasma Membrane Transport Proteins