title: Sodium chloride enhanced oligomerization of L-glutamic acid in aqueous solution.
abstract: The presence of NaCl was found to significantly enhance the formation of longer peptides in N,N'-carbonyldiimidazole induced oligomerization of L-glutamic acid in homogeneous aqueous solution. The enhancement was detected in the presence of as low as 0.01-M NaCl and the highest yield of longer oligomers was achieved in the presence of 1-M NaCl. The possible prebiotic relevance is discussed.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. wangkj@moon.ibp.ac.cn
authors.forename: Kong-Jiang
authors.initials: KJ
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.forename: Chen
authors.initials: C
authors.lastname: Li
mesh_terms: D002851:Chromatography, High Pressure Liquid; D019418:Evolution, Chemical; D018698:Glutamic Acid / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D007700:Kinetics; D000069497:Origin of Life; D011108:Polymers / Q000138:chemical synthesis*; D012965:Sodium Chloride / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D011108:Polymers; D018698:Glutamic Acid; D012965:Sodium Chloride; C006900:N,N-carbonyldiimidazole