[Neurogenesis and depression: etiology or new illusion?].
New hippocampal neurons are continuously generated in the adult brain of several animal species. Several studies have demonstrated that a variety of environmental factors, including stress, influence the proliferation of hippocampal cells. Thus, stress induced decrease of hippocampal neurogenesis seem to be an important factor in the etiology of depression. In this review the relationship between neurogenesis and depression has been emphasized.
Scorza
Fulvio Alexandre
FA
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. scorza.nexp@epm.br
Guerra
Alexandro de Borja Gonçalves
Ade B
Cavalheiro
Esper Abrão
EA
Calil
Helena Maria
HM
D000818:Animals; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000503:physiopathology; D003863:Depression / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology