title: Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy.
abstract: The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.
authors.affiliation: Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. linjj@uci.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Lin
authors.forename: N
authors.initials: N
authors.lastname: Salamon
authors.forename: R A
authors.initials: RA
authors.lastname: Dutton
authors.forename: A D
authors.initials: AD
authors.lastname: Lee
authors.forename: J A
authors.initials: JA
authors.lastname: Geaga
authors.forename: K M
authors.initials: KM
authors.lastname: Hayashi
authors.forename: A W
authors.initials: AW
authors.lastname: Toga
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: P M
authors.initials: PM
authors.lastname: Thompson
mesh_terms: D000328:Adult; D001284:Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional; D007407:Interviews as Topic; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D019635:Neurosurgical Procedures; D018579:Patient Selection; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*