Regulating mammalian transcription with RNA.
Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.
Corey
David R
DR
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA. david.corey@utsouthwestern.edu
D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D006801:Humans; D008322:Mammals; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010944:Plants / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs; D012313:RNA; D004247:DNA