title: [Applanation tonometry in "normal" patients and patients after LASIK].
abstract: BACKGROUND
  Until now it was thought that morphological parameters of the eye such as corneal thickness, corneal curvature and axial length do not affect tonometry results. However, the aim of this study was to find out whether there actually is an influence of these parameters on applanation tonometry.
  
  
  METHODS
  In this prospective study we examined 125 eyes of 125 normal patients with a corneal thickness of 568.8 +/- 43.79 microm, a corneal curvature of 7.72 +/- 0.27 mm and an axial length of 23.62 +/- 2.05 mm. Before performing a phacoemulsification, the anterior chamber was temporarily punctured. With a closed system the intraocular pressure (IOP) was manometrically set at 20, 35 and 50 mmHg using an H (2)O column. The IOP was then measured with a Perkins tonometer. With these patients we compared 102 eyes that had undergone LASIK due to a myopia of 6.3 +/- 2.17 D. Before and 6 months after surgery, IOD, k-values and central corneal thickness of these patients were measured.
  
  
  RESULTS
  At all set pressure levels there was a highly significant correlation of measured IOP and corneal thickness. At all set pressure levels the measured IOP significantly depended on corneal thickness (r(2) = 0.78 - 0.83). After LASIK, IOP was reduced from 16.5 +/- 2.1 to 12.9 +/- 1.9 mmHg. There was a significant correlation between IOP and corneal curvature as well as corneal thickness (r(2) = 0.631; P < 0.001). The biomechanical characteristics of the cornea are changed so that the measured IOP has to be corrected by an additional 0.75 mmHg.
  
  
  CONCLUSIONS
  Since corneal thickness does affect Goldmann applanation tonometry we recommend to use the "Dresden Correction Table" (Tab. ) to achieve the real IOP. Pressure measurements after LASIK are inaccurate because of a change in corneal biomechanics, corneal thickness and curvature and they should be corrected as follows: IOP (real) = IOP (measured) + (540 - CCT)/71 + (43 - K-value)/2.7 + 0.75 mmHg.
authors.affiliation: Universitäts-Augenklinik Carl Gustav Carus, Dresden. markus.kohlhaas@uniklinikum-dresden.de
authors.forename: M
authors.initials: M
authors.lastname: Kohlhaas
authors.forename: E
authors.initials: E
authors.lastname: Spörl
authors.forename: A G
authors.initials: AG
authors.lastname: Böhm
authors.forename: K
authors.initials: K
authors.lastname: Pollack
authors.forename: D
authors.initials: D
authors.lastname: Sandner
authors.forename: L E
authors.initials: LE
authors.lastname: Pillunat
mesh_terms: D000368:Aged; D000465:Algorithms; D016477:Artifacts; D002138:Calibration; D003315:Cornea / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D020731:Keratomileusis, Laser In Situ; D008297:Male; D009216:Myopia / Q000175:diagnosis* / Q000601:surgery*; D011785:Quality Assurance, Health Care / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014065:Tonometry, Ocular / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome