[Study of biocompatibility of polybutylcyanoacrylate nanoparticles].
OBJECTIVE
To evaluate the biocompatibility of polybutylcyanoacrylate nanoparticles (PBCA-NP) manufactured by emulsion polymerization technique.


METHODS
MTT assay was performed for evaluation of the cytotoxicity of PBCA-NP (e.g. cell proliferation and hemolytic test) experiments of long-term subcutaneous implantation and implantation in the muscular tissues of PBCA-NP was conducted in rabbits to observe the inflammatory reactions due to the implantation.


RESULTS
No obvious cytotoxicity or hemolytic reactions were observed (with the hemolytic rate at different concentrations of PBCA-NP(5%). Three months after PBCA-NP implantation, obvious lymphocyte infiltration was not observed in the tissues around the implants which underwent gradual degradation.


CONCLUSIONS
PBCA-NP possesses good biocompatibility.
Yang
Xi-xiao
XX
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yaxx@263.net
Chen
Jan-hai
JH
Guo
Dan
D
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D004337:Drug Carriers; D004659:Enbucrilate / Q000494:pharmacology*; D005260:Female; D020007:Implants, Experimental; D008422:Materials Testing; D018482:Muscle, Skeletal / Q000601:surgery; D053758:Nanoparticles; D011090:Polyenes; D011817:Rabbits
D001672:Biocompatible Materials; D004337:Drug Carriers; D011090:Polyenes; C008952:polybutene; D004659:Enbucrilate