title: Genetics. Motivating hotspots.
abstract: Only recently have we begun to characterize fine-scale recombination rates in mammals. In her Perspective, Przeworski discusses the work by Myers et al. in which linkage disequilibrium data have been used to produce a high-resolution recombination map for most of the human genome. More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity.
authors.affiliation: Department of Human Genetics, University of Chicago, 920 East 57th Street, 507F CLSC, Chicago, IL 60637, USA. mfp@uchicago.edu
authors.forename: Molly
authors.initials: M
authors.lastname: Przeworski
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D011995:Recombination, Genetic / Q000235:genetics*