title: Linkage analysis of two families with X-linked recessive congenital motor nystagmus.
abstract: X-linked recessive congenital motor nystagmus was identified in two Chinese families living in the Guangdong province of China. Nystagmus was noticed in early childhood. Only males in the families were affected and all obligate carriers did not have nystagmus. Linkage study was performed using microsatellite markers at about 10 cM intervals on the X chromosome. The nystagmus in these two families is linked to markers in the region of chromosome Xq23-q27, including DXS1001, DXS8009, and DXS1047. DXS1047 gave the highest lod score of 3.53 at theta = 0.
authors.affiliation: Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Guo
authors.affiliation: Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Jia
authors.affiliation: Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
authors.forename: Xueshan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
authors.forename: Panfeng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China. qingjiongzhang@yahoo.com.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China. qingjiongzhang@yahoo.com.
authors.forename: Qingjiong
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D041321:Chromosomes, Human, X; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D020417:Nystagmus, Congenital / Q000235:genetics*; D010375:Pedigree