Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptides.
In situ hybridization on paraffin sections of the rat brain showed that synthetic peptides Vilon, Epithalon, and Cortagen modulated the expression of IL-2 gene in vivo in cells of some hypothalamic structures depending on the terms and routes of administration.
Kazakova
T B
TB
Department of General Pathology and pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Moscow.
Barabanova
S V
SV
Novikova
N S
NS
Glushikhina
M S
MS
Khavinson
V Kh
VKh
Malinin
V V
VV
Korneva
E A
EA
D000280:Administration, Inhalation; D000818:Animals; D007031:Hypothalamus / Q000166:cytology* / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007273:Injections, Intramuscular; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D007376:Interleukin-2; D009842:Oligopeptides; D012333:RNA, Messenger