[Relationship between cyclooxygenase (COX)-2 and malignant tumors].
Recently, epidemiologic studies and animal experiments have demonstrated that nonsteroidal anti-inflammatory drugs(NSAIDs) reduce the incidence of colorectal carcinoma. Cyclooxygenase(COX) is the principal target of NSAIDs. COX is the first oxidase in the process of prostaglandins(PGs) production from arachidonic acid(AA). PGs and COX enzyme may be involved in the initiation and/or the promotion of carcinogenesis because the major action of NSAIDs is the inhibition of COX. In this review, we demonstrated the expression of COX-2 in urological cancer(renal cell carcinoma, bladder tumor, prostate cancer, and testicular tumor) tissues as well as the effects of COX inhibitors.
Yoshimura
Rikio
R
Department of Urology, Osaka City University Graduate School of Medicine.
Matsuyama
Masahide
M
Tsuchida
Kenji
K
Takemoto
Yoshiaki
Y
Nakatani
Tatsuya
T
D051546:Cyclooxygenase 2 / Q000032:analysis*; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology; D008297:Male; D011471:Prostatic Neoplasms / Q000201:enzymology; D013736:Testicular Neoplasms / Q000201:enzymology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology; D014571:Urologic Neoplasms / Q000201:enzymology*
D051546:Cyclooxygenase 2