Bacterial mechanisms to overcome inhibitory effects of dietary tannins.
High concentrations of tannins in fodder plants inhibit gastrointestinal bacteria and reduce ruminant performance. Increasing the proportion of tannin-resistant bacteria in the rumen protects ruminants from anti-nutritional effects. The reason for the protective effect is unclear, but could be elucidated if the mechanism(s) by which tannins inhibit bacteria and the mechanisms of tannin resistance were understood. A review of the literature indicates that the ability of tannins to complex with polymers and minerals is the basis of the inhibitory effect on gastrointestinal bacteria. Mechanisms by which bacteria can overcome inhibition include tannin modification/degradation, dissociation of tannin-substrate complexes, tannin inactivation by high-affinity binders, and membrane modification/repair and metal ion sequestration. Understanding the mechanism of action of tannins and the mechanism(s) bacteria use to overcome the inhibitory effects will allow better management of the rumen ecosystem to reduce the anti-nutritional effects of tannin-rich fodder plants and thereby improve ruminant production.
Smith
Alexandra H
AH
Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.
Zoetendal
Erwin
E
Mackie
Roderick I
RI
D000821:Animal Feed; D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D010944:Plants / Q000737:chemistry; D051381:Rats; D012417:Rumen / Q000382:microbiology*; D013634:Tannins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D013634:Tannins