title: Initial ischemic event: perfusion-weighted MR imaging and apparent diffusion coefficient for stroke evolution.
abstract: OBJECTIVE
  To prospectively determine if the degree of acute perfusion or diffusion abnormalities measured prior to treatment onset help predict the evolution of brain infarction on magnetic resonance (MR) images.
  
  
  METHODS
  Local ethics committee approval and informed consent were obtained. On parametric maps obtained in 64 patients (mean age, 64 years +/- 13 [standard deviation]; 37 men and 27 women) with acute middle cerebral artery infarction, lesion volumetry was performed to determine time to peak, mean transit time, cerebral blood volume, and apparent diffusion coefficient obtained within 3 hours of symptom onset. The infarct lesions were assessed on T2-weighted MR images obtained at follow-up on day 8. Cerebrovascular changes were determined on MR angiograms. Inferential and correlation statistics were used.
  
  
  RESULTS
  A perfusion delay of more than 6 seconds relative to the nonaffected hemisphere on time-to-peak maps helped to predict the lesion volume on T2-weighted images (r = 0.686, P < .001). In contrast, neither the volume nor the degree of the diffusion abnormality helped to predict the infarct volume (r < 0.46). This was because in one subgroup of patients there was an increase and in one subgroup there was a decrease in infarct volume on the T2-weighted images (P < .001). There was a greater prevalence (P < .02) of cerebral artery abnormalities in the patients with larger infarcts. Clinically, the neurologic impairment was more severe (P < .01) and the mean arterial pressure higher (P < .04) in these patients.
  
  
  CONCLUSIONS
  The results suggest that in acute stroke the severity of the initial ischemic event as determined on time-to-peak maps indicates hemodynamic compromise in addition to internal carotid artery or middle cerebral artery occlusion, because of abnormalities in other cerebral arteries.
authors.affiliation: Department of Neurology, Heinrich-Heine University of Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany. seitz@neurologie.uni-duesseldorf.de
authors.forename: Rüdiger J
authors.initials: RJ
authors.lastname: Seitz
authors.forename: Stefanie
authors.initials: S
authors.lastname: Meisel
authors.forename: Patrick
authors.initials: P
authors.lastname: Weller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Junghans
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Wittsack
authors.forename: Mario
authors.initials: M
authors.lastname: Siebler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000175:diagnosis* / Q000628:therapy; D002560:Cerebrovascular Circulation; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D020521:Stroke / Q000175:diagnosis* / Q000628:therapy; D015912:Thrombolytic Therapy