Immunization with recombinant Streptococcus pneumoniae neuraminidase NanA protects chinchillas against nasopharyngeal colonization.
Immunization with recombinant S. pneumoniae neuraminidase NanA (rNanA) resulted in a significant reduction in pneumococcal colonization in the chinchilla model. The bacteria were eliminated from the nasopharynx 1 week earlier than that from the control cohort. Our data suggest that rNanA affords protection against pneumococcal nasopharyngeal colonization.
Tong
H H
HH
Division of Otologic Research, College of Medicine and Public Health, The Ohio State University, Room 4331 Cramblett Hall, 456 W. 10th Ave., Columbus, OH 43210, USA.
Li
D
D
Chen
S
S
Long
J P
JP
DeMaria
T F
TF
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology; D002353:Carrier State / Q000382:microbiology; D002682:Chinchilla / Q000276:immunology* / Q000382:microbiology*; D005260:Female; D007114:Immunization; D008297:Male; D009305:Nasopharynx / Q000382:microbiology*; D009439:Neuraminidase / Q000235:genetics / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000201:enzymology* / Q000276:immunology*
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D011994:Recombinant Proteins; D009439:Neuraminidase