title: Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.
abstract: The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin).
authors.affiliation: Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: T
authors.initials: T
authors.lastname: Hari Babu
authors.forename: P V
authors.initials: PV
authors.lastname: Srinivas
authors.forename: K
authors.initials: K
authors.lastname: Hara Kishore
authors.forename: U S N
authors.initials: US
authors.lastname: Murthy
authors.forename: J Madhusudana
authors.initials: JM
authors.lastname: Rao
mesh_terms: D018926:Anti-Allergic Agents / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009025:Morpholines / Q000737:chemistry; D010936:Plant Extracts / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D018926:Anti-Allergic Agents; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D009025:Morpholines; D010936:Plant Extracts; C043561:chrysin; D002244:Carbon