Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.
The vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic mediators related to inflammation-associated synovial angiogenesis. The aim of this study was to asses the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants with rheumatoid arthritis (RA). The population under study was composed of a total of 753 unrelated RA patients and 801 healthy controls. The VEGF -1154 G-->A and -634 G-->C polymorphism genotyping was performed by real-time polymerase chain reaction technology, using TaqMan 5' allelic discrimination assay. No evidence of association was observed between the -1154 G-->A and the -634 G-->C VEGF polymorphisms, or inferred VEGF haplotypes with RA susceptibility or clinical manifestations. Our results suggest that the analyzed VEGF promoter polymorphisms may not play a relevant role in RA pathogenesis in our population.
Rueda
Blanca
B
Instituto de Parasitología y Biomedicina, Granada, Spain.
González-Gay
M Angel
MA
López-Nevot
M Angel
MA
García
A
A
Fernández-Arquero
M
M
Balsa
Alejandro
A
Pablos
J Luis
JL
Pascual-Salcedo
Dora
D
de la Concha
Emilio Gómez
EG
González-Escribano
M Francisca
MF
Martín
Javier
J
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012217:Rheumatoid Factor / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000235:genetics*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004247:DNA; D012217:Rheumatoid Factor