Tremors and chorea induced by trimethoprim-sulfamethoxazole in a child with Pneumocystis pneumonia.
A 1.5-year-old girl developed high frequency tremors and chorea after receiving a dose of 120 mg/kg/d trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of Pneumocystis pneumonia. The child was human immunodeficiency virus-negative but immunocompromised because of prolonged immunosuppressive therapy. These symptoms disappeared 3 days after TMP-SMX was discontinued. Pediatricians should be aware of tremors and chorea among the potential adverse effects of high doses of TMP-SMX.
Bua
Jenny
J
Department of Pediatrics, Institute of Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Marchetti
Federico
F
Barbi
Egidio
E
Sarti
Armando
A
Ventura
Alessandro
A
D000890:Anti-Infective Agents / Q000009:adverse effects*; D002819:Chorea / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007223:Infant; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000382:microbiology; D014202:Tremor / Q000139:chemically induced*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination