In vitro photo-release of a TRPV1 agonist.
Intracellular photolysis of a novel 'caged' capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1.
Carr
James L
JL
EaStCHEM, School of Chemistry and Centre for Biomolecular Sciences, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK.
Wease
Kerrie N
KN
Van Ryssen
Michael P
MP
Paterson
Suzanne
S
Agate
Ben
B
Gallagher
Katherine A
KA
Brown
C Tom A
CT
Scott
Roderick H
RH
Conway
Stuart J
SJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002211:Capsaicin / Q000031:analogs & derivatives*; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology; D004594:Electrophysiology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008027:Light; D008956:Models, Chemical; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013329:Structure-Activity Relationship; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors*
D004224:Diterpenes; D007473:Ion Channels; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; C493922:Trpv1 protein, rat; C024353:resiniferatoxin; D002211:Capsaicin; D002118:Calcium