KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.
OBJECTIVE
To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.


METHODS
Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.


RESULTS
Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).


CONCLUSIONS
The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
Tang
Wei
W
Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
Inagaki
Yoshinori
Y
Kokudo
Norihiko
N
Guo
Qian
Q
Seyama
Yasuji
Y
Nakata
Munehiro
M
Imamura
Hiroshi
H
Sano
Keiji
K
Sugawara
Yasuhiko
Y
Makuuchi
Masatoshi
M
D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D000941:Antigens / Q000378:metabolism*; D000951:Antigens, Neoplasm; D003138:Common Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000378:metabolism*
D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins