title: Directional positive selection on an allele of arbitrary dominance.
abstract: Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.
authors.affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA. kteshima@uchicago.edu
authors.forename: Kosuke M
authors.initials: KM
authors.lastname: Teshima
authors.forename: Molly
authors.initials: M
authors.lastname: Przeworski
mesh_terms: D000465:Algorithms; D000483:Alleles; D005075:Biological Evolution; D005787:Gene Frequency; D005799:Genes, Dominant; D005808:Genes, Recessive; D014644:Genetic Variation; D005828:Genetics, Population; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012641:Selection, Genetic