title: B-type natriuretic peptide plasma concentration in acutely poisoned patients.
abstract: B-type natriuretic peptide (BNP) is synthesized in the cardiac ventricles upon ventricular myocyte stretch. BNP plasma concentration is useful in cardiology especially for identifying patients with congestive heart failure (CHF), as a prognostic marker of acute coronary syndromes and independent predictor of sudden cardiac death. Its value in clinical toxicology is unclear. As toxins frequently produce deleterious effects on the cardiovascular system we have decided to carry out the pilot study on BNP plasma levels in acutely poisoned patients. The 117 patients (65 males and 52 females) treated at the Department of Clinical Toxicology Jagiellonian University Medical College in Kraków in 2004 were included. 42 of them were intoxicated with ethanol, 35 with pharmaceuticals (mostly tricyclic antidepressants), 13 with CO. The mean age of examined group was 34.07 +/- 12.08 year. The control group consisted of 54 healthy volunteers and employees of the Department (mean age; 32.7 +/- 11.74). A significantly higher BNP concentration was found in poisoned patients than in the control group. The highest BNP plasma concentration was noted in pharmaceutical poisoned patients. Mean BNP concentration in poisonings of minor severity (grade 1) was significantly lower then in moderate (grade 2) or severe (grade 3) poisonings. BNP plasma measurement as an additional marker of cardiac disturbances in clinical toxicology practice may be suggested.
authors.affiliation: Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Pach
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gawlikowski
authors.forename: Dorota
authors.initials: D
authors.lastname: Targosz
authors.forename: Barbara
authors.initials: B
authors.lastname: Groszek
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wilimowska
mesh_terms: D000208:Acute Disease; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000097:blood / Q000506:poisoning*; D015415:Biomarkers / Q000097:blood; D002249:Carbon Monoxide Poisoning / Q000097:blood*; D016022:Case-Control Studies; D002492:Central Nervous System Depressants / Q000097:blood / Q000506:poisoning*; D000431:Ethanol / Q000097:blood / Q000506:poisoning*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011041:Poisoning / Q000097:blood; D011044:Poland; D012720:Severity of Illness Index
chemical_list: D000929:Antidepressive Agents, Tricyclic; D015415:Biomarkers; D002492:Central Nervous System Depressants; D020097:Natriuretic Peptide, Brain; D000431:Ethanol