A case of disseminated histoplasmosis successfully treated with the investigational drug posaconazole.
A 79-year-old man with a 3-month history of weight loss and fever was diagnosed with disseminated histoplasmosis. When the infection became refractory to itraconazole therapy, posaconazole was prescribed. The patient became asymptomatic within 1 month of beginning treatment, and his general health improved. Posaconazole was discontinued after 6 months, and the patient has remained well since.
Clark
B
B
Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Glossop Road, Sheffield, South Yorkshire, UK. ben.clark@bdgh-tr.trent.nhs.uk
Foster
R
R
Tunbridge
A
A
Green
S
S
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006658:Histoplasma / Q000187:drug effects; D006660:Histoplasmosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D015507:Drugs, Investigational; D014230:Triazoles; C101425:posaconazole