Fulminant hepatitis due to varicella zoster virus in a girl with acute lymphoblastic leukemia in remission: report of a case and review.
The authors describe a 4-year-old girl with acute lymphoblastic leukemia in remission who developed fulminant hepatic failure due to varicella-zoster virus (VZV). Diagnosing VZV visceral infection in immunocompromised patients is often difficult due to atypical clinical presentation with few or no skin lesions and severe abdominal or back pain. Prompt initiation of empirical treatment with acyclovir and VZV immunoglobulin pending results of the serum polymerase chain reaction for VZV is warranted in this clinical setting.
Mantadakis
Elpis
E
Department of Pediatric Hematology/Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece.
Anagnostatou
Nicole
N
Danilatou
Vassiliki
V
Markaki
Erasmia-Athina
EA
Spanaki
Anna-Maria
AM
Briassoulis
George
G
Kalmanti
Maria
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002644:Chickenpox / Q000188:drug therapy / Q000821:virology*; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000821:virology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000503:physiopathology*; D012074:Remission Induction