title: MAP-based kinetic analysis for voxel-by-voxel compartment model estimation: detailed imaging of the cerebral glucose metabolism using FDG.
abstract: We propose a novel algorithm for voxel-by-voxel compartment model analysis based on a maximum a posteriori (MAP) algorithm. Voxel-by-voxel compartment model analysis can derive functional images of living tissues, but it suffers from high noise statistics in voxel-based PET data and extended calculation times. We initially set up a feature space of the target radiopharmaceutical composed of a measured plasma time activity curve and a set of compartment model parameters, and measured the noise distribution of the PET data. The dynamic PET data were projected onto the feature space, and then clustered using the Mahalanobis distance. Our method was validated using simulation studies, and compared with ROI-based ordinary kinetic analysis for FDG. The parametric images exhibited an acceptable linear relation with the simulations and the ROI-based results, and the calculation time took about 10 min. We therefore concluded that our proposed MAP-based algorithm is practical.
authors.affiliation: Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1, Naka, Itabashi, Tokyo 173-0022, Japan. ukimura@ieee.org
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Mika
authors.initials: M
authors.lastname: Naganawa
authors.forename: Jun
authors.initials: J
authors.lastname: Yamaguchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takabayashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Uchiyama
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oda
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology; D001931:Brain Mapping; D003196:Computer Graphics; D003198:Computer Simulation; D004734:Energy Metabolism / Q000502:physiology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007700:Kinetics; D016018:Least-Squares Analysis; D017711:Nonlinear Dynamics; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000706:statistics & numerical data*; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18