[Flow injection analysis of ciprofloxacin by terbium sensitized chemiluminescence method].
A new flow injection chemiluminescence (CL) method for the determination of Ciprofloxacin (CPLX) was described. The method was based on the weak CL reaction of Ce(IV)-SO3(2-) sensitized by Tb3+ -CPLX. The relative CL intensity was linear with the concentration of CPLX in the range of 9.0 x 10(-9)-1.0 x 10(-6) mol x L(-1). The detection limit is 2.2 x 10(-11) mol x L(-1). The relative standard deviation (RSD) for the determination of 5.0 x 10(-8) mol x L(-1) CPLX is 3.0% (n = 11). The method has been successfully applied to the analysis of CPLX in tablet and capsule. An original mechanism was proposed to explain this phenomenon.
Lian
Ning
N
Department of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Wang
Jian-chao
JC
Leng
Wen-hong
WH
Chang
Xi-jun
XJ
D002214:Capsules; D002563:Cerium / Q000737:chemistry; D002939:Ciprofloxacin / Q000032:analysis* / Q000097:blood / Q000652:urine; D017022:Flow Injection Analysis; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D008956:Models, Chemical; D015203:Reproducibility of Results; D013447:Sulfites / Q000737:chemistry; D013725:Terbium / Q000737:chemistry*
D002214:Capsules; D013447:Sulfites; D013725:Terbium; D002563:Cerium; D002939:Ciprofloxacin