[Association of -160(C-->A) polymorphism in CDH1 gene with gastric cancer risk in Fujian Chinese population].
OBJECTIVE
CDH1, encoding E-cadherin, is an important tumor suppressor gene. The present study aims to investigate the association of -160(C-->A) polymorphism in CDH1 gene with susceptibility to gastric cancer in Fujian province.


METHODS
One hundred and two patients from independent families and 101 healthy control subjects were analyzed. Genotype analysis was performed through polymerase chain reaction-based denaturing high performance liquid chromatography. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression model.


RESULTS
The frequencies of -160(C-->A) polymorphism CC, CA and AA genotype in case group and controls were 58(56.9%), 38(37.3%)ì6(5.9%) and 55(54.5%), 41(40.6%), 5(5%), respectively. AA genotype did not present a significantly increased risk for gastric cancer (OR=1.12; 95% CI:0.32-3.95). No association was found between A allele and clinicopathological characteristics of gastric cancer.


CONCLUSIONS
-160(C-->A) polymorphism in CDH1 gene promoter region may not be in association with genetic susceptibility to gastric cancer in Chinese population from Fujian.
Song
Chuan-gui
CG
Department of Oncology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian, PR China. songchuangui@yahoo.com
Huang
Chang-ming
CM
Liu
Xing
X
Lu
Hui-shan
HS
Zhang
Xiang-fu
XF
Huang
Wei
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics*; D002681:China; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology
D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins