title: [Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province].
abstract: OBJECTIVE
  To investigate the polymorphism of HLA-A, -B, -DRB1 genes in Han population in Shanxi of China.
  
  
  METHODS
  Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to identify the polymorphism of HLA-A, -B, -DRB1 genes of 7440 healthy and unrelated individuals of Han population in Shanxi, and the gene frequency distribution of HLA-A, -B, -DRB1 genes in population was compared with the results from other populations.
  
  
  RESULTS
  Eighteen HLA-A, forty HLA-B and thirteen HLA-DRB1 alleles were found. The frequencies of A*02, A*24, A*11, A*01, A*03, B*13, B*51, B*15, B*40, B*35, DRB1*15, DR*09, DR*12, DR*04, DR*07 alleles in Hans of Shanxi were significantly higher and displayed distinctive distribution profiles when compared with those of Caucasian and Afro-American.
  
  
  CONCLUSIONS
  The HLA-A,-B,-DRB1 distribution in Shanxi Han population shares some genetic characteristics with other Han populations in northern part of China, but it exhibits its own characteristics.
authors.affiliation: Department of Pediatrics, People's Hospital of Shanxi Province, Taiyuan, Shanxi, PR China. Lantao111@sina.com
authors.forename: Tao
authors.initials: T
authors.lastname: Lan
authors.forename: De-mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Gui-qin
authors.initials: GQ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains