title: Shape optimization in unsteady blood flow: a numerical study of non-Newtonian effects.
abstract: This paper presents a numerical study of non-Newtonian effects on the solution of shape optimization problems involving unsteady pulsatile blood flow. We consider an idealized two dimensional arterial graft geometry. Our computations are based on the Navier-Stokes equations generalized to non-Newtonian fluid, with the modified Cross model employed to account for the shear-thinning behavior of blood. Using a gradient-based optimization algorithm, we compare the optimal shapes obtained using both the Newtonian and generalized Newtonian constitutive equations. Depending on the shear rate prevalent in the domain, substantial differences in the flow as well as in the computed optimal shape are observed when the Newtonian constitutive equation is replaced by the modified Cross model. By varying a geometric parameter in our test case, we investigate the influence of the shear rate on the solution.
authors.affiliation: University of Pennsylvania, Mechanical Engineering and Applied Mechanics, Philadelphia, PA 19104, USA.
authors.forename: Feby
authors.initials: F
authors.lastname: Abraham
authors.forename: Marek
authors.initials: M
authors.lastname: Behr
authors.forename: Matthias
authors.initials: M
authors.lastname: Heinkenschloss
mesh_terms: D000465:Algorithms; D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery; D001698:Biomedical Engineering; D001783:Blood Flow Velocity; D001807:Blood Vessel Prosthesis; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011673:Pulsatile Flow / Q000502:physiology*