Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli.
A time-course gene-expression profile was generated for Escherichia coli TK31 when it was exposed to an organic solvent mixture, and classified by fuzzy adaptive resonance theory (Fuzzy ART). It was found that the purR regulon plays an important role in the organic solvent tolerance (OST) of E. coli.
Shimizu
Kazunori
K
Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Hayashi
Shuhei
S
Doukyu
Noriyuki
N
Kobayashi
Takeshi
T
Honda
Hiroyuki
H
D004361:Drug Tolerance / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D017143:Fuzzy Logic; D020869:Gene Expression Profiling / Q000379:methods*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects / Q000502:physiology; D008657:Metabolic Clearance Rate; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D009930:Organic Chemicals / Q000494:pharmacology*; D018085:Regulon / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012997:Solvents / Q000494:pharmacology*
D029968:Escherichia coli Proteins; D009930:Organic Chemicals; C489317:PurR protein, E coli; D012097:Repressor Proteins; D012997:Solvents