'Sweetening' natural products via glycorandomization.
In an effort to explore the contribution of the sugar constituents of pharmaceutically relevant glycosylated natural products, chemists have developed glycosylation methods for the generation of 'glycorandomized' libraries. Each member of these libraries is uniquely differentiated by an attached carbohydrate. Recently, two complementary glycorandomization strategies have emerged: chemoenzymatic glycorandomization, a biocatalytic approach dependent upon the substrate promiscuity of enzymes to activate and attach sugars to natural products, and neoglycorandomization, an efficient one-step chemical sugar ligation reaction that does not require prior sugar protection or activation. These strategies are likely to have a significant impact on fundamental glycoscience and drug discovery.
Griffith
Byron R
BR
Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, 53705, USA.
Langenhan
Joseph M
JM
Thorson
Jon S
JS
D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D006031:Glycosylation; D014166:Transferases / Q000737:chemistry*
D002241:Carbohydrates; D014166:Transferases