Angiotensinogen and plasminogen activator inhibitor-1 gene polymorphism in relation to renovascular disease.
The present study was designed to evaluate angiotensinogen (AGT) M235T and plasminogen activator inhibitor-1 (PAI-1) (4G/5G) polymorphisims in relation to the occurrence of atherosclerotic renal artery stenosis (ARAS) and recurrent stenosis. In this study, 30 patients were enrolled after angiographic demonstration of ARAS; 100 healthy subjects for AGT polymorphism and 80 healthy subjects for PAI-1 polymorphism were considered the control group. The patients were followed for a mean 46.1 +/- 9.2 months. The patients had significantly higher frequencies of the MT genotype and the T allele than control group (chi(2) = 18.2, p < 0.001 and chi(2) = 11.5 p < 0.001). There were no significant differences in the PAI-1 genotype and allele findings when the data for all patients were compared with that for the controls (chi(2)= 2.45, p = 0.29 and chi(2) = 0.019, p = 0.89). There were no significant differences in the genotype and allele findings for the patients with and without restenosis (p > 0.05). The C-reactive protein (CRP) level was higher in the patients with restenosis than in the patients without restenosis (7.694 +/- 0.39 mg/L and 1.56 +/- 1.08 mg/L) (p = 0.001). Our results suggest that the M235T MT genotype and T allele might be associated with increased risk of atherosclerotic renal artery stenosis. The CRP level might be an independent predictor for recurrent stenosis.
Reis
Kadriye Altok
KA
Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey. akadriyer@hotmail.com
Onal
Baran
B
Gonen
Sevim
S
Arinsoy
Turgay
T
Erten
Yasemin
Y
Ilgit
Erhan
E
Soylemezoglu
Oguz
O
Derici
Ulver
U
Guz
Galip
G
Bali
Musa
M
Sindel
Sukru
S
D000483:Alleles; D000792:Angiography; D000808:Angiotensinogen / Q000235:genetics*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012008:Recurrence; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000235:genetics*; D018709:Statistics, Nonparametric
D017395:Plasminogen Activator Inhibitor 1; D000808:Angiotensinogen