title: Correlation between polarimetric retinal nerve fiber layer thickness and retinal sensitivity determined with frequency-doubling technology.
abstract: OBJECTIVE
  Correlation between polarimetric retinal nerve fiber layer thickness measured with variable corneal compensation and retinal sensitivity measured with frequency-doubling technology (FDT) and standard automated perimetry (SAP) was investigated.
  
  
  METHODS
  Twenty-four consecutive patients with chronic open-angle glaucoma and 17 healthy control subjects (1 randomly selected eye for each subject) were evaluated.
  
  
  RESULTS
  For all subjects, quadrant scanning laser polarimetry parameters correlated positively with both FDT and SAP mean sensitivity of the opposite hemifield (P< .001). Global scanning laser polarimetry parameters correlated positively with FDT-mean sensitivity, SAP-mean sensitivity, and FDT-mean deviation, and negatively with SAP-mean deviation (in SAP, mean deviation is positive in case of sensitivity loss) (P < or = .02). The nerve fiber indicator also correlated with FDT-pattern standard deviation and SAP-corrected loss variance (P < or = .01). Using un-logged sensitivity values, no further correlations were found.
  
  
  CONCLUSIONS
  Our results show that a similar structure-function relationship exists between polarimetric retinal nerve fiber layer thickness determined with variable corneal compensation and retinal sensitivity measured with SAP and FDT.
authors.affiliation: 1st Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Katsanos
authors.forename: P
authors.initials: P
authors.lastname: Kóthy
authors.forename: A G P
authors.initials: AG
authors.lastname: Konstas
authors.forename: P
authors.initials: P
authors.lastname: Vargha
authors.forename: G
authors.initials: G
authors.lastname: Holló
mesh_terms: D000328:Adult; D000886:Anthropometry; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007834:Lasers; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000473:pathology*