Prominent positive U waves appearing with high-dose intravenous phenylephrine.
A 71-year-old woman who had critical cerebral ischemia secondary to a carotid artery occlusion was receiving high-dose intravenous phenylephrine for a trial of hypertensive therapy. While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug. The possible underlying electrophysiological mechanisms of this phenomenon are discussed in this paper.
Hefer
David
D
Department of Pharmacology, Columbia University, New York, NY 10032, USA. dvh2101@columbia.edu
Bukharovich
Inna
I
Nasrallah
E John
EJ
Plotnikov
Alexei
A
D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D010656:Phenylephrine / Q000008:administration & dosage* / Q000009:adverse effects*
D000959:Antihypertensive Agents; D010656:Phenylephrine