Stereometrical peculiriaties of energy-forming ultrastructures of pancreatic beta -cells under lipid loading during aging.
Chronic lipid loading in pancreatic beta -cells mitochondria of young and old animals causes the activation of ATP generation necessary for insulin secretion, activation of signalling system necessary for initiation of insulin secretion (the morphologic equivalents of which are revealed by elevation of volume share of mitochondrial matrix and increase of volume and number of crysts in the beta -cells), more prominent in old organisms. After loading with lipids in the certain term in young age mitochondrial processes are normalized (matrix turns back to initial volume, the crysts - to initial size and number), whereas in old age in comparison with the norm the activity of ATP-synthesis and signalling system are markedly impaired (significant decrease of matrix volume part and number of crysts, very marked elevation of volume part of aggregative-destructive sites, most important widening of intramembranous space); in some part of mitochondria complete energetic lack and blockage of signalling system take place (in some mitochondria the destructive-disorganization processes are markedly evident).
Kasradze
D
D
Department of Pathology, Tbilisi State Medical University.
Beriashvili
R
R
D000375:Aging / Q000502:physiology*; D000818:Animals; D004032:Diet; D004734:Energy Metabolism / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000648:ultrastructure*; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats; D015398:Signal Transduction / Q000502:physiology
D005230:Fatty Acids, Nonesterified; D007328:Insulin