Small intestinal submucosa intracardiac patch: an experimental study.
In this experimental study, small intestinal submucosa was implanted as an atrial prosthesis in calves. Echocardiography and histology showed this to be an impermeable prosthesis that develops a neointimal nonthrombogenic surface making it safe for repair of defects in a low-pressure system. Further study with small intestinal submucosa in an intracardiac position is warranted.
Rosen
Michael
M
Cleveland Clinic Foundation Department of General Surgery, Cleveland, OH 44195, USA.
Roselli
Eric E
EE
Faber
Cristiano
C
Ratliff
Norman B
NB
Ponsky
Jeffrey L
JL
Smedira
Nicholas G
NG
D000818:Animals; D001707:Biopsy, Needle; D006348:Cardiac Surgical Procedures / Q000379:methods*; D002417:Cattle; D004195:Disease Models, Animal; D006084:Graft Rejection; D006085:Graft Survival; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000637:transplantation*; D007421:Intestine, Small; D008297:Male; D008943:Mitral Valve / Q000473:pathology* / Q000601:surgery*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013524:Surgical Flaps