title: [Calcium as a regulator of intracellular processes in actinomycetes: a review].
abstract: Data on the effects of calcium ions (Ca2+) on processes of morphological and physiological differentiation in cultures of actinomycetes have been reviewed, with emphasis on representatives of the genus Streptomyces. Evidence accumulated thus far, of the regulatory role of serine-threonine protein kinases in the differentiation and of the possible involvement of Ca2+-dependent protein kinases in secondary metabolism (including antibiotic biosynthesis) are analyzed. The possibility that regulatory elements of apoptosis (including Ca2+-dependent) function in actinomycetes is discussed. A hypothesis is advanced, according to which determinants of antibiotic resistance play a key role in the network of signal transduction systems of actinomycetes.
authors.forename: V N
authors.initials: VN
authors.lastname: Danilenko
authors.forename: V A
authors.initials: VA
authors.lastname: Mironov
authors.forename: S M
authors.initials: SM
authors.lastname: Elizarov
mesh_terms: D039903:Actinobacteria / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology; D002118:Calcium / Q000502:physiology*; D004351:Drug Resistance; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017346:Protein Serine-Threonine Kinases; D002118:Calcium