title: Ultrasonographic and biochemical parameters in the non-invasive evaluation of liver fibrosis in hepatitis C virus chronic hepatitis.
abstract: BACKGROUND
  Prior studies suggest that platelet counts of <140 000/microL can discriminate patients with different stages of fibrosis.
  
  
  OBJECTIVE
  To determine the added value of abdominal ultrasound analysis of morphological liver features in increasing the diagnostic accuracy of platelet counts for the prediction of liver fibrosis at histology.
  
  
  METHODS
  In a retrospective study, clinical records of 1143 chronic hepatitis C patients at their first presentation, naives to both liver biopsy and anti-viral treatment, were reviewed. Sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios of following indices were evaluated singularly or in combination: platelet counts <140 000/microL; nodular liver surface, spleen and portal vein size.
  
  
  RESULTS
  All indices had specificity rate of > or =90% in excluding bridging fibrosis/cirrhosis, whereas sensitivity was acceptable (51%) for only platelet counts <140 000/microL. None of the ultrasonographic parameters singularly evaluated and reached an acceptable sensitivity rate. For ruling cirrhosis in or out, specificity rate was > or =82% for all tests, with the highest value reported by portal vein size. Low platelet counts plus nodular liver surface had the best sensitivity.
  
  
  CONCLUSIONS
  No additional significant predictive value was given by adding ultrasonographic parameters to low platelet counts, whereas only a mild non-significant improvement in sensitivity was obtained combining platelet counts <140 000/microL with the presence of nodular liver surface. The platelet counts <140 000/microL showed the best predictive value for including both significant fibrosis and cirrhosis.
authors.affiliation: Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy. an.iacobellis@libero.it
authors.forename: A
authors.initials: A
authors.lastname: Iacobellis
authors.forename: S
authors.initials: S
authors.lastname: Fusilli
authors.forename: A
authors.initials: A
authors.lastname: Mangia
authors.forename: R
authors.initials: R
authors.lastname: Clemente
authors.forename: V
authors.initials: V
authors.lastname: Festa
authors.forename: A
authors.initials: A
authors.lastname: Giacobbe
authors.forename: D
authors.initials: D
authors.lastname: Facciorusso
authors.forename: G
authors.initials: G
authors.lastname: Niro
authors.forename: P
authors.initials: P
authors.lastname: Conoscitore
authors.forename: A
authors.initials: A
authors.lastname: Andriulli
mesh_terms: D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014463:Ultrasonography