Standard atlas space for C57BL/6J neonatal mouse brain.
A standard atlas space with stereotaxic co-ordinates for the postnatal day 0 (P0) C57BL/6J mouse brain was constructed from the average of eight individual co-registered MR image volumes. Accuracy of registration and morphometric variations in structures between subjects were analyzed statistically. We also applied this atlas coordinate system to data acquired using different imaging protocols as well as to a high-resolution histological atlas obtained from separate animals. Mapping accuracy in the atlas space was examined to determine the applicability of this atlas framework. The results show that the atlas space defined here provides a stable framework for image registration for P0 normal mouse brains. With an appropriate feature-based co-registration strategy, the probability atlas can also provide an accurate anatomical map for images acquired using invasive imaging methods. The atlas templates and the probability map of the anatomical labels are available at http://www.loni.ucla.edu/MAP/ .
Lee
Erh-Fang
EF
Department of Neurology, Laboratory of Neuro Imaging, Reed Neurological Research Center, UCLA School of Medicine, Room 4238, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA.
Jacobs
Russell E
RE
Dinov
Ivo
I
Leow
Alex
A
Toga
Arthur W
AW
D000716:Anatomy, Artistic; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping; D019295:Computational Biology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000592:standards; D008488:Medical Illustration; D008636:Mesencephalon / Q000033:anatomy & histology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000033:anatomy & histology*; D012249:Rhombencephalon / Q000033:anatomy & histology; D013687:Telencephalon / Q000033:anatomy & histology