Hydrolysed milk in preterm infants: an open problem.
OBJECTIVE
To review knowledge about the role, indications and nutritional adequacy of protein hydrolysate formulas (HF) in the preterm newborn.


METHODS
A review of the available literature was carried out.


RESULTS
No data support the use of HF for atopy prevention. HF could have a positive role in the early feeding of very-low-birthweight infants, but several concerns exist about their nutritional adequacy.


CONCLUSIONS
Further investigations addressing protein and mineral metabolism as well as long-term effects, including neurodevelopment, are needed.
Zuppa
Antonio A
AA
Division of Neonatology, Department of Paediatrics, Catholic University of the Sacred Heart, Rome, Italy. zuppaaa@rm.unicatt.it
Visintini
Federica
F
Cota
Francesco
F
Maggio
Luca
L
Romagnoli
Costantino
C
Tortorolo
Giuseppe
G
D002657:Child Development / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D016269:Milk Hypersensitivity / Q000517:prevention & control*; D008895:Milk, Human / Q000737:chemistry*; D009751:Nutritional Requirements; D018529:Nutritional Support; D011492:Protein Hydrolysates / Q000737:chemistry*
D011492:Protein Hydrolysates