Eater: a big bite into phagocytosis.
The phagocytosis of invading microorganisms by specialized blood cells is a crucial element of innate immunity in both mammals and insects. In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila.
Ertürk-Hasdemir
Deniz
D
Division of Infectious Disease, University of Massachusetts Medical School, Worcester 01605, USA.
Silverman
Neal
N
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D017124:Conserved Sequence; D004330:Drosophila / Q000166:cytology / Q000196:embryology / Q000235:genetics / Q000382:microbiology*; D004625:Embryo, Nonmammalian; D004926:Escherichia coli / Q000472:pathogenicity; D016368:Frameshift Mutation; D017344:Genes, Insect; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D046228:Microarray Analysis; D008969:Molecular Sequence Data; D016296:Mutagenesis; D010587:Phagocytosis; D017434:Protein Structure, Tertiary; D034622:RNA Interference; D051116:Receptors, Scavenger / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D012706:Serratia marcescens / Q000472:pathogenicity
D019476:Insect Proteins; D008565:Membrane Proteins; D051116:Receptors, Scavenger