Radiotherapy-induced ocular surface disease.
Today radiation is routinely used as a therapeutic modality for select tumors of the orbit, adnexa, paranasal sinus, and nasopharynx. Despite significant improvements in mechanisms of delivery and protective shielding, acute and chronic complications of radiation can affect different segments of the eye. In this report, we provide an overview of ocular damage secondary to radiotherapy. We identify the characteristic clinical changes and underlying pathophysiologic mechanisms involving the ocular surface and provide a rational approach to their prevention and treatment.
Barabino
Stefano
S
Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, 02114, USA.
Raghavan
Anita
A
Loeffler
Jay
J
Dana
Reza
R
D005123:Eye / Q000528:radiation effects*; D005128:Eye Diseases / Q000209:etiology*; D005134:Eye Neoplasms / Q000532:radiotherapy; D006801:Humans; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D012720:Severity of Illness Index