title: Quantifying structural and functional restraints on amino acid substitutions in evolution of proteins.
abstract: One of Oleg Ptitsyn's most important papers (Shakhnovich, E., Abkevich, V., and Ptitsyn, O. (1996) Nature, 379, 96-98) describes how knowledge of structure and function can be used to understand better the nature of amino acid substitutions in families and superfamilies of proteins. The selective advantages of retaining structure and function during evolution can be expressed as restraints on the amino acid substitutions that are accepted.
authors.affiliation: Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, England.
authors.forename: V
authors.initials: V
authors.lastname: Chelliah
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D000465:Algorithms; D019943:Amino Acid Substitution / Q000235:genetics*; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D019143:Evolution, Molecular; D006801:Humans; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D012641:Selection, Genetic
chemical_list: D011506:Proteins