Diversity of gastric carcinogenesis.
Gastric cancer is still the second leading cause of cancer death worldwide, although the incidence of this disease has been gradually decreasing. The diversity of gastric cancer is well known. However, the mechanism underlying this diversity is still unknown. We have performed experimental and clinical studies on gastric carcinogenesis. These results suggest that the variety in the type and extent of inflammation in the stomach, and the different response to inflammation are responsible for the diversity in gastric carcinogenesis. This concept is supported by clinical and experimental evidence that eradication of Helicobacter pylori diminishes the incidence of gastric cancer and that PPAR gamma ligand, a modulator of inflammation and cell differentiation, prevents gastric carcinogenesis.
Kaminishi
Michio
M
Department of Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. e05011@h.u-tokyo.ac.jp
D000818:Animals; D005756:Gastritis / Q000150:complications; D016481:Helicobacter Infections / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000150:complications*; D047492:Peroxisome Proliferator-Activated Receptors / Q000502:physiology; D011230:Precancerous Conditions; D012727:Sex Characteristics; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology
D047492:Peroxisome Proliferator-Activated Receptors