title: Injection-moulded models of major and minor arteries: the variability of model wall thickness owing to casting technique.
abstract: Cardiovascular disease of major and minor arteries is a common cause of death in Western society. The wall mechanics and haemodynamics within the arteries are considered to be important factors in the disease formation process. This paper is concerned with the development of an efficient computer-integrated technique to manufacture idealized and realistic models of diseased major and minor arteries from radiological images and to address the issue of model wall thickness variability. Variations in wall thickness from the original computer models to the final castings are quantified using a CCD camera. The results found that wall thickness variation from the major and minor idealized artery models to design specification were insignificant, up to a maximum of 16 per cent. In realistic models, however, differences were up to 23 per cent in the major arterial models and 58 per cent in the minor arterial models, but the wall thickness variability remained within the limits of previously reported wall thickness results. It is concluded that the described injection moulding procedure yields idealized and realistic castings suitable for use in experimental investigations, with idealized models giving better agreement with design. Wall thickness is variable and should be assessed after the models are manufactured.
authors.affiliation: Centre for Applied Biomedical Engineering Research and Materials and Surface Science Institute, Department of Mechanical and Aeronautical Engineering, University of Limerick, Limerick, Ireland. thomas.obrien@ul.ie
authors.forename: T
authors.initials: T
authors.lastname: O'Brien
authors.forename: L
authors.initials: L
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: O'Donnell
authors.forename: M
authors.initials: M
authors.lastname: Walsh
authors.forename: T
authors.initials: T
authors.lastname: McGloughlin
mesh_terms: D019412:Anatomy, Cross-Sectional / Q000295:instrumentation* / Q000379:methods*; D000818:Animals; D001158:Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008420:Manufactured Materials; D008953:Models, Anatomic; D008955:Models, Cardiovascular