title: Paracoccidioidomycosis in patients with human immunodeficiency virus: review of 12 cases observed in an endemic region in Brazil.
abstract: OBJECTIVE
  To study the clinical characteristics of 12 patients with paracoccidioidomycosis (PCM) and human immunodeficiency virus (HIV) infection.
  
  
  METHODS
  The clinical manifestations, diagnosis, treatment, and outcome of PCM in 12 patients infected with HIV attended at a University Hospital of Mato Grosso do Sul, Brazil, were evaluated.
  
  
  RESULTS
  All patients were men, mean age 36.1 years old, and 11 had a diagnosis other than PCM as the aids-defining illness. Lymph nodes were the organs most often involved (10 patients, 83.3%), followed by lung involvement, usually with an interstitial pattern (seven patients, 58.3%), papule-nodular skin lesions with central ulceration in six (50%) and ulcerated lesions of oral mucous membrane in five (41.6%) patients. Pleural involvement occurred in one patient who presented large pleural effusion beside a pathologic rib fracture caused by P. brasiliensis. Seven patients showed involvement in more than one extrapulmonary organ. In eight (66.6%) cases the diagnosis was established by direct microscopy of clinical specimens. All patients used trimethoprim-sulfamethoxazole and seven patients were also treated with amphotericin B. Eight patients died with progressive PCM manifestations.
  
  
  CONCLUSIONS
  Our review demonstrates that PCM, an endemic systemic mycosis in Brazil, when associated with AIDS, behaves clinically as an opportunistic disease.
authors.affiliation: Postgraduate Program, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, RJ, Brazil. anapaniago@terra.com.br
authors.forename: Anamaria Mello Miranda
authors.initials: AM
authors.lastname: Paniago
authors.forename: Ana Carolina Carli
authors.initials: AC
authors.lastname: de Freitas
authors.forename: Eliana Setti Albuquerque
authors.initials: ES
authors.lastname: Aguiar
authors.forename: José Ivan Albuquerque
authors.initials: JI
authors.lastname: Aguiar
authors.forename: Rivaldo Venâncio
authors.initials: RV
authors.lastname: da Cunha
authors.forename: Ana Rita Coimbra Motta
authors.initials: AR
authors.lastname: Castro
authors.forename: Bodo
authors.initials: B
authors.lastname: Wanke
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D019353:Endemic Diseases; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010228:Paracoccidioides / Q000302:isolation & purification; D010229:Paracoccidioidomycosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents