title: Herpes simplex virus and toll-like receptors.
abstract: The earliest interactions between viruses and host cells are critical to determining the outcome of infections. The interactions between a virus and its host cells that lead to the production of inflammatory cytokines are essential to the development of T cells and antibodies that provide long-term defense against the invaders. At the same time, however, these same cytokines (or sometimes other mediators or chemokines) stimulate inflammation, which may lead to localized tissue damage and/or systemic circulatory collapse and death. This review focuses on the interaction between Toll-like receptors, a critical component of the innate immune system of mammals, and their role in herpes simplex pathogenesis and immunity.
authors.affiliation: Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. robertfinberg@umassmed.edu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Finberg
authors.forename: David M
authors.initials: DM
authors.lastname: Knipe
authors.forename: Evelyn A
authors.initials: EA
authors.lastname: Kurt-Jones
mesh_terms: D000818:Animals; D018925:Chemokines / Q000096:biosynthesis; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D008954:Models, Biological; D015398:Signal Transduction; D018139:Simplexvirus / Q000276:immunology* / Q000472:pathogenicity; D051195:Toll-Like Receptor 2 / Q000276:immunology; D051217:Toll-Like Receptor 9 / Q000276:immunology; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology*
chemical_list: D018925:Chemokines; D051195:Toll-Like Receptor 2; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors; D007372:Interferons