title: Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats.
abstract: Eleven controlled studies were conducted in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid nematodes Toxocara cati and Toxascaris leonina. Infections were induced by administration of larvated ascarid eggs, and stage-specific efficacy was evaluated by treating cats at scheduled intervals post-inoculation. All studies featured random allocation to treatment groups, placebo-treated control animals and assessment of outcome measures by masked personnel. The product (emodepside+praziquantel topical solution) was 100% effective against mature adults and immature adult T. cati. In addition, it was 96.8% effective against third stage larvae and at least 99.4% effective against fourth stage larvae of T. cati, respectively. Efficacy against mature, immature adult and L4 stages of T. leonina exceeded 93.4%, but regulatory "adequacy of infection" criteria were not met in some studies. No adverse reactions to treatment were noted in cats treated with the emodepside+praziquantel topical solution.
authors.affiliation: East Tennessee Clinical Research, Knoxville, Tennessee, USA. creinemey@aol.com.
authors.forename: C R
authors.initials: CR
authors.lastname: Reinemeyer
authors.affiliation: Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Charles
authors.affiliation: Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Buch
authors.affiliation: Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
authors.forename: T
authors.initials: T
authors.lastname: Settje
authors.affiliation: Bayer HealthCare AG, Animal Health Division, R&D Parasiticides, 51368, Leverkusen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Altreuther
authors.affiliation: Professional Laboratory Research Services, North Carolina, USA.
authors.forename: L
authors.initials: L
authors.lastname: Cruthers
authors.affiliation: TRS Laboratories, Georgia, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: McCall
authors.affiliation: Young Veterinary Research Services, Turlock, Callfornia, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Young
authors.affiliation: Institute of Parasitology, Hannover School of Veterinary Medicine, Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Epe
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D047630:Depsipeptides / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D011223:Praziquantel / Q000008:administration & dosage* / Q000627:therapeutic use*; D014119:Toxocara / Q000145:classification / Q000187:drug effects; D014120:Toxocariasis / Q000188:drug therapy*
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D011223:Praziquantel; C468987:emodepside