title: A case of hypoplastic left heart syndrome and bicuspid aortic valve in monochorionic twins.
abstract: The etiology of hypoplastic left heart syndrome (HLHS) remains unclear. Since a genetic cause for HLHS has not been obvious, it is generally considered to be inherited in a multifactorial manner. Studies of twins are valuable in elucidating the genetic contribution to a birth defect such as HLHS. We report a case of monochorionic twins in whom one has HLHS and the other has a bicuspid aortic valve. Predisposing genetic and environmental influences on individuals with identical genotypes, such as twins, may result in discordance of left-sided flow lesions.
authors.affiliation: Wilford Hall Medical Center/859th MDOS, 2200 Bergquist Drive, Suite 1, Lackland AFB, TX 78236-5300, USA. thornton.mu@lackland.af.mil
authors.forename: T S
authors.initials: TS
authors.lastname: Mu
authors.forename: R M
authors.initials: RM
authors.lastname: McAdams
authors.forename: D M
authors.initials: DM
authors.lastname: Bush
mesh_terms: D001021:Aortic Valve / Q000002:abnormalities*; D004200:Diseases in Twins; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D007231:Infant, Newborn; D008297:Male; D014430:Twins, Monozygotic