Histological study on comparison between NASH and ALD.
We examined the histological findings of non-alcoholic steatohepatitis (NASH) and ALD to study resemblance and difference of these two diseases. At a glance of H&E staining, they looked same, however, careful examination on silver impregnation histology, the fibrosis of NASH showed lattice fibrosis on the other hand ALD showed solid fibrosis. The appearance of fibrosis was different due to qualitative difference. More examination on the change of hepatocytes, there were some difference in incidence of the findings such as megamitochondria, bile stasis, hemosiderin deposition, vacuolic nuclei, and lipogranuroma. So we are able to differentiate NASH and ALD histologically.
Nakano
Masayuki
M
National Hospital Organization, Chiba Medical Center (former National Chiba Hospital), Division of Laboratory Investigation, 4-1-2, Tsubakimori, Chuo-ku, Chiba 260-8606, Japan.
Fukusato
Toshio
T