title: Effect of ganglioside on synaptic plasticity of hippocampus in lead-exposed rats in vivo.
abstract: Synaptic plasticity, including long-term potentiation (LTP), long-term depression (LTD) and depotentiation (DP), is important for learning and memory. Previous studies proved that chronic lead exposure especially during early post-natal development induced impairment on synapse plasticity. The purpose of this study is to evaluate the effect of ganglioside on the lead-induced impairments of LTP and DP in rat dentate gyrus in vivo. The experiments were carried out in three groups of rats (control, lead-exposed, ganglioside-treated lead-exposed, respectively). The input-output (I/O) function, pair pulses reaction, excitatory post-synaptic potential (EPSP) and population spike (PS) amplitude were measured in the dentate gyrus (DG) of adult rats (70-90 days) in response to stimulation applied to the lateral perforant path. The results show that (1) chronic lead exposure impaired LTP/DP measured on both EPSP slope and PS amplitude in DG area of the hippocampus. (2) The amplitudes of LTP/DP of lead-exposed group were significantly increased by supplying ganglioside. These results suggest intraperitoneally injection with ganglioside could reverse the lead-induced impairments of synaptic plasticity in rats and might be effective in attenuating the cognitive deficits induced by lead.
authors.affiliation: School of Life Science and Institute of Polar Environment, University of Science and Technology of China, Hefei, Anhui 230027, PR China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: She
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Da-Miao
authors.initials: DM
authors.lastname: Zhu
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Sun
authors.forename: Di-Yun
authors.initials: DY
authors.lastname: Ruan
mesh_terms: D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D005732:Gangliosides / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007854:Lead / Q000633:toxicity*; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
chemical_list: D005732:Gangliosides; D007854:Lead