Effect of nonselective beta-adrenoblockers on the state of sympathoadrenal system and ratio of neuroactive amino acids in rat medulla oblongata.
Experiments on rats showed that injection of propranolol into the medulla oblongata increased the contents of epinephrine, norepinephrine, dopamine, and L-DOPA by 3.76, 1.4, 2.0, and 1.7 times, respectively. These propranolol-induced changes in the levels and ratio of neurotransmitters were not accompanied by variations in serotonin content. Propranolol had no significant effects on the content of excitatory amino acids, except marked increase in aspartate content. The level of inhibitory amino acids increased mainly due to an increase in GABA content. The balance between excitatory and inhibitory amino acids was shifted towards inhibitory compounds.
Turovaya
A Yu
AY
Krasnodar Regional Medical Research Center; NV Karsanov Republican Research Center for Medical Biophysics and New Biomedical Technologies, Tbilisi.
Kiguradze
M I
MI
Galenko-Yaroshevskii
P A
PA
Kade
A Kh
AKh
Uvarov
A V
AV
Tatulashvili
D R
DR
Sukoyan
G V
GV
D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000596:Amino Acids; D002395:Catecholamines; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D011433:Propranolol