title: Creatine monohydrate and resistance training increase bone mineral content and density in older men.
abstract: Our purpose was to determine the effects of creatine supplementation combined with resistance training on bone mineral content and density in older men. Twenty-nine older men (age 71 y) were randomized (double blind) to receive creatine (0.3 g/kg creatine for 5 d and 0.07 g/kg thereafter) or placebo while participating in resistance training (12 weeks). Bone mineral content and density were determined by dual energy X-ray absorptiometry before and after training. There was a time main effect for whole-body and leg bone mineral density (p < or = 0.05) with these measures increasing by approximately 0.5%, and 1%, respectively in the combined groups. There was a group by time interaction for arms bone mineral content, with the group receiving creatine increasing by 3.2% (p < 0.01) and the group receiving placebo decreasing by 1.0% (not significant). Changes in lean tissue mass of the arms correlated with changes in bone mineral content of the arms (r = 0.67; p < 0.01). Resistance training of 12 weeks increases bone mineral density in older men and creatine supplementation may provide an additional benefit for increasing regional bone mineral content. The increase in bone mineral content may be due to an enhanced muscle mass with creatine, with potentially greater tension on bone at sites of muscle attachment.
authors.affiliation: College of Kinesiology, University of Saskatchewan, Saskatoon SK, Canada, S7N 5B2. phil.chilibeck@usask.ca
authors.forename: P D
authors.initials: PD
authors.lastname: Chilibeck
authors.forename: M J
authors.initials: MJ
authors.lastname: Chrusch
authors.forename: K E
authors.initials: KE
authors.lastname: Chad
authors.forename: K
authors.initials: K
authors.lastname: Shawn Davison
authors.forename: D G
authors.initials: DG
authors.lastname: Burke
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000222:Adaptation, Physiological; D000368:Aged; D000375:Aging; D000704:Analysis of Variance; D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D003401:Creatine / Q000494:pharmacology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D014891:Weight Lifting / Q000502:physiology*; D016474:Weight-Bearing / Q000502:physiology
chemical_list: D003401:Creatine