title: Time course of diastolic and systolic function improvement after pulmonary valve replacement in adult patients with tetralogy of Fallot.
abstract: OBJECTIVE
  The aim of this research was to assess right ventricular diastolic and systolic function before and after pulmonary valve replacement (PVR) in adult patients after repair of tetralogy of Fallot.
  
  
  BACKGROUND
  Pulmonary valve replacement (PVR) in adult patients late after repair of tetralogy of Fallot leads to rapid improvement of right ventricular (RV) systolic function.
  
  
  METHODS
  A total of 16 patients and 8 healthy subjects were included. Median age at initial repair was 4.9 (0.9 to 13.1) years, and mean age at PVR was 28.7 (19.5 to 45.6) years. Cardiac magnetic resonance imaging was performed before and 8 and 22 months after PVR. Right ventricular volumes and function as well as RV in- and outflow patterns were assessed.
  
  
  RESULTS
  The volume of the early filling of the RV (Evol) increased from 49.8 +/- 14.7 ml to 53.8 +/- 19.3 ml (not significant) and 62.0 +/- 18.9 ml, respectively (p < 0.05), whereas the volume of the atrial contraction (Avol) remained unchanged. Consequently, the Evol/Avol ratio increased from 1.4 +/- 0.7 before PVR to 1.6 +/- 0.7 at 8 months (not significant) and 2.3 +/- 1.2 at 22 months (p < 0.01). The Evol/Avol ratio was not significantly different from the healthy subjects at 22 months, indicating late recovery of diastolic function. Systolic function improved rapidly after PVR; the indexed RV end-systolic volume decreased from 93.7 +/- 33.0 ml/m2 to 60.9 +/- 18.4 ml/m2 (p < 0.01) and 54.8 +/- 21.0 ml/m2 (p < 0.01).
  
  
  CONCLUSIONS
  In adult patients late after total repair of Fallot, PVR leads to late improvement of diastolic function. We speculate that the rapid volume unloading after PVR increases systolic performance, whereas improvement in diastolic function requires long-term remodeling.
authors.affiliation: Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. A.van_Straten@LUMC.nl
authors.forename: Alexander
authors.initials: A
authors.lastname: van Straten
authors.forename: Hubert W
authors.initials: HW
authors.lastname: Vliegen
authors.forename: Hildo J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: Stijntje D
authors.initials: SD
authors.lastname: Roes
authors.forename: Ernst E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: Mark G
authors.initials: MG
authors.lastname: Hazekamp
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011664:Pulmonary Valve / Q000601:surgery*; D013771:Tetralogy of Fallot / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D016278:Ventricular Function, Right