Screening of some rare endemic Italian plants for inhibitory activity on 5-lipoxygenase.
The extracts of four rare plants found on the islands of Sicily, Vulcano and Marettimo, Southern Italy, were screened for their inhibitory effect on the production of leukotriene B4 by 5-lipoxygenase in intact cells. The methanol extracts of pods of Cytisus aeolicus and aerial parts of Thymus richardii were the most active extracts, inhibiting almost completely the leukotriene B4 production at 200 and 50 microg/ml, respectively.
Prieto
José-María
JM
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, Valencia, Spain.
Bader
Ammar
A
Martini
Francesca
F
Ríos
José-Luis
JL
Morelli
Ivano
I
D000818:Animals; D029865:Cytisus; D039761:Genista; D007975:Leukotriene B4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000187:drug effects*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D029606:Plumbaginaceae; D051381:Rats; D017208:Rats, Wistar; D012802:Sicily; D046930:Thymus Plant
D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D007975:Leukotriene B4