[Isopropyl myristate molecular gels and drug-loaded transdermal capability].
OBJECTIVE
To prepare of isopropyl myristate (IPM) molecular gels and investigate of its transdermal capability.


METHODS
Microstructure of IPM gels was studied by scanning electron microscope (SEM) and optical microscope (OM). The rheology and thixotropy of IPM gels were investigated by viscosity. Triptolide was used as model drug to investigate its transdermal capability.


RESULTS
The microstructure of IPM gels was a three-dimension network formed by the aggregation of Span 60 in IPM, which was rod-like tubular aggregate. It has good rheology and thixotropy. There was a good linear correlation between the accumulative permeated amount per unit area and the time for triptolide-loaded IPM gels. The permeation process agreed with zero order pharmacokinetics. The average permeability through rat skin for triptolide was 19.26 ng x cm(-2) x h(-1), which was 2.92 times of triptolide unguents obtained commercially available.


CONCLUSIONS
Isopropyl myristate molercular gel can be formed by span 60 assemblies. Transdermal capability drug-loaded IPM gels was better than that of triptolide unguents.
Lin
Li-hua
LH
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China.
Zhang
Xue-qin
XQ
Yang
Ya-jiang
YJ
Yang
Xiang-liang
XL
Xu
Hui-bi
HB
D000279:Administration, Cutaneous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004224:Diterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D004337:Drug Carriers; D004852:Epoxy Compounds; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009226:Myristates / Q000737:chemistry / Q000494:pharmacology*; D010616:Phenanthrenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D010946:Plants, Medicinal / Q000737:chemistry; D012212:Rheology; D012869:Skin Absorption / Q000187:drug effects*; D029757:Tripterygium / Q000737:chemistry; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D004337:Drug Carriers; D004852:Epoxy Compounds; D009226:Myristates; D010616:Phenanthrenes; C008205:isopropyl myristate; C001899:triptolide