Scaffolds for microtubule inhibition through extensive modification of the epothilone template.
Cachoux
Frédéric
F
ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Hönggerberg, HCI H 405, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
Isarno
Thomas
T
Wartmann
Markus
M
Altmann
Karl-Heinz
KH
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D034261:Epothilones; D014404:Tubulin