[The etiology and pathogenesis of infantile pyloric stenosis].
As it is known, pyloric stenosis among newborns and infants represents a high or complete obturation caused by stomach circular muscles hypertrophy. This disease is widely spread in the world. According to the reference data, the prevalence of this disease is about one per 200-300 newborns. Despite of the many surveys and investigations, ethiopathogenesis of pylorostenosis remains the issue of debates. Some of the authors consider pyloric stenosis as the innate defect of evolution, while others think that the enlargement of pylorus circular muscles is caused by working hypertrophy. According to our tests performed on the laboratory animals and developed experimental model of the disease, pyloric stenosis may be considered as an inborn pathology. The leading place in its etiology takes the partial impenetrability caused by the swelling of pylorus mucus (allergic, inflammation) and as a consequence development of working hypertrophy.
Simonishvili
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Department of Pediatric Surgery and Critical Medicine, department of Clinical Anatomy of Georgian State Medical Academy.
Bagaturia
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I
D000818:Animals; D006801:Humans; D007223:Infant; D011707:Pyloric Stenosis / Q000209:etiology* / Q000503:physiopathology*