title: Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.
abstract: The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) gene and adiponectin, a protein secreted from adipose tissue, have been associated with insulin sensitivity. The present study demonstrates that in Finnish servicemen who were on a high-caloric diet for 6 mo only subjects with the Ala 12 allele of PPARgamma2 had a significant increase in adiponectin levels with weight loss induced by heavy exercise. This study demonstrates an interaction of genetic and environmental factors in the regulation of serum adiponectin concentrations.
authors.affiliation: Department of Public Health Science and General Practice, University of Oulu, Finland. fmousavi@student.oulu.fi
authors.forename: Firoozeh
authors.initials: F
authors.lastname: Mousavinasab
authors.forename: Tuula
authors.initials: T
authors.lastname: Tähtinen
authors.forename: Jari
authors.initials: J
authors.lastname: Jokelainen
authors.forename: Pentti
authors.initials: P
authors.lastname: Koskela
authors.forename: Mauno
authors.initials: M
authors.lastname: Vanhala
authors.forename: Jorma
authors.initials: J
authors.lastname: Oikarinen
authors.forename: Sirkka
authors.initials: S
authors.lastname: Keinänen-Kiukaanniemi
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015444:Exercise; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D015431:Weight Loss / Q000235:genetics
chemical_list: D052242:Adiponectin; D047495:PPAR gamma