title: [Clinical experience of sivelestat sodium hydrate for severe reexpansion pulmonary edema; report of a case].
abstract: An 81-year-old man was referred to our hospital for the treatment for left spontaneous pneumothorax. A chest X-ray revealed a left-sided total pneumothorax and complete collapse of the lung. After intravenous administration of methylprednisolone, a 16 Fr chest tube was inserted, and drainage was started without negative pressure suction. Four hours after chest tube insertion, the patient's condition deteriorated. He complained severe cough and dyspnea, and pulse oximetry reading was 70%. A repeat chest X-ray demonstrated diffuse reexpansion pulmonary edema (RPE) on the left. After mechanical ventilation and intravenous infusion therapy with sivelestat sodium hydrate, methylprednisolone and ulinastatin were started, P(O2)/ Fi(O2) ratio improved rapidly. He was extubated on hospital day 6 and was discharged after pleurodesis for the pneumothorax. This case suggests that sivelestat sodium hydrate may be useful for the treatment for RPE.
authors.affiliation: Department of Thoracic and General Surgery, Akita Kumiai General Hospital, Akita, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Endo
authors.forename: A
authors.initials: A
authors.lastname: Tsukahara
authors.forename: M
authors.initials: M
authors.lastname: Shimoyama
authors.forename: M
authors.initials: M
authors.lastname: Mitsui
authors.forename: K
authors.initials: K
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004322:Drainage; D005998:Glycine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D011030:Pneumothorax / Q000628:therapy*; D011654:Pulmonary Edema / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D020551:Pulse Therapy, Drug; D012121:Respiration, Artificial; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; C069195:sivelestat; D005998:Glycine; D008775:Methylprednisolone