title: Rhabdomyosarcoma of the cervix in sisters with review of the literature.
abstract: OBJECTIVE
  Pediatric embryonal heterologous rhabdomyosarcoma of the cervix is a rare tumor.
  
  
  METHODS
  We present an interesting clinico-pathologic situation of two sisters presenting with pediatric embryonal heterologous rhabdomyosarcoma of the cervix.
  
  
  RESULTS
  Pediatric embryonal heterologous rhabdomyosarcomas of the cervix are relatively uncommon. After a Pubmed search from 1952 to present, to our knowledge, this is the only report involving sisters presenting with this disease. Treatment has been extrapolated from collaborative groups such as Intergroup Rhabdomyosarcoma Study (IRS) Group so that optimal management may be achieved.
  
  
  CONCLUSIONS
  We urge continued reporting of these rare tumors to enhance understanding if there may be a genetic component associated with them.
authors.affiliation: Department of Surgery, Division of Gynecologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14209, USA.
authors.forename: Jeannine A
authors.initials: JA
authors.lastname: Villella
authors.forename: Paul N
authors.initials: PN
authors.lastname: Bogner
authors.forename: Sheila N
authors.initials: SN
authors.lastname: Jani-Sait
authors.forename: Anne Marie W
authors.initials: AM
authors.lastname: Block
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006801:Humans; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000473:pathology; D035781:Siblings; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology