title: Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.
abstract: In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia.
authors.affiliation: Department of East-West Medicine, Graduate School, Kyung-Hee University, Seoul, South Korea.
authors.forename: Sun Kwang
authors.initials: SK
authors.lastname: Kim
authors.forename: Byung-Il
authors.initials: BI
authors.lastname: Min
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Byung Gil
authors.initials: BG
authors.lastname: Hwang
authors.forename: Gi Yong
authors.initials: GY
authors.lastname: Yoo
authors.forename: Dong Suk
authors.initials: DS
authors.lastname: Park
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Na
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003080:Cold Temperature; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control*; D017288:Pain Threshold / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology*; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D011224:Prazosin / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000601:surgery*; D013997:Time Factors; D015016:Yohimbine / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D015016:Yohimbine; D011224:Prazosin; D010646:Phentolamine