Physical analysis of a processive molecular motor: the conventional kinesin.
We present a model that allows for the derivation of the experimentally accessible observables: spatial steps, mean velocity, stall force, useful power, efficiency and randomness, etc. as a function of the [adenosine triphosphate] concentration and an external load F. The model presents a minimum of adjustable parameters and the theoretical predictions compare well with the available experimental results.
Ciudad
A
A
Departament d'Estructura i Constituents de la Matèria, Facultat de Física, Universitat de Barcelona, Diagonal 647, E-08028 Barcelona, Spain. aciudad@ecm.ub.es
Lacasta
A M
AM
Sancho
J M
JM
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000502:physiology; D003198:Computer Simulation; D016547:Kinesins / Q000737:chemistry* / Q000502:physiology*; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000502:physiology*; D009068:Movement / Q000502:physiology
D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D016547:Kinesins