title: [Amisulpride in Huntington's disease].
abstract: OBJECTIVE
  Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects.
  
  
  METHODS
  We report four cases of patients with clinically and genetically established Huntington's disease and signs of psychosis who were treated with Amisulpride.
  
  
  RESULTS
  Two patients developed extrapyramidal side effects due to the treatment. The antipsychotic therapy of all patients was effective.
  
  
  CONCLUSIONS
  Due to degeneration of striatal neurons patients suffering from Huntington's disease react early with development of extrapyramidal side effects after therapy with amisulpride.
authors.affiliation: Neurologische Klinik der Ruhr-Universität Bochum, St. Josef-Hospital, Huntington Zentrum NRW, Bochum. carsten.saft@cityweb.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Saft
authors.forename: Jürgen
authors.initials: J
authors.lastname: Andrich
authors.forename: Peter H
authors.initials: PH
authors.lastname: Kraus
authors.forename: Horst
authors.initials: H
authors.lastname: Przuntek
mesh_terms: D000368:Aged; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003702:Delusions / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D009483:Neuropsychological Tests; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000175:diagnosis; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride