title: Candida glabrata fungemia cured by antibiotic-lock therapy: case report and short review.
abstract: Catheter removal is now the standard recommendation of catheter-related fungemia even when tunneled devices are used. However, in the clinical practice, this procedure is not always without risks. Antibiotic-lock technique can resolve many cases of catheter-related bacteraemia, but cure of catheter-related candidemia by this method has been attempted in very few instances, reviewed in this article. Herein, we report a case of non-complicated Candida glabrata fungemia related to a Hickman catheter used for parenteral nutrition, cured with intraluminal amphotericin B in addition to systemic therapy. This case demonstrates that 'antifungal-lock therapy' can be effectively used in selected cases of catheter-related candidemia.
authors.affiliation: Unidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Angel-Moreno
authors.forename: M
authors.initials: M
authors.lastname: Boronat
authors.forename: M
authors.initials: M
authors.lastname: Bolaños
authors.forename: A
authors.initials: A
authors.lastname: Carrillo
authors.forename: S
authors.initials: S
authors.lastname: González
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez Arellano
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D041221:Candida glabrata / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000382:microbiology*; D004866:Equipment Contamination / Q000517:prevention & control; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D010288:Parenteral Nutrition
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole