title: Lack of prefrontal repetitive transcranial magnetic stimulation effects in time production processing.
abstract: The aim of the present study was to determine the effects of high frequency repetitive transcranial magnetic stimulation (rTMS) over different neuroanatomical areas [left and right doroslateral prefrontal cortex (DLPFC) and right cerebellar hemisphere] on time production task. The study was performed in 16 healthy right-handed men with a cross-over, within subject repeated measures design. There were four rTMS conditions: baseline without stimulation, high frequency rTMS over right, left DLPFC and over right cerebellum. The volunteers were asked to produce a 3-min interval by internal counting. The rTMS was applied during the task. No significantly differences were observed in absolute error scores in time estimation task with any rTMS condition. This preliminary study does not support the role of the prefrontal lobe in time production processes.
authors.affiliation: Cognitive and Movement Disorders Section, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Catalonia, Spain. agironell@santpau.es
authors.forename: A
authors.initials: A
authors.lastname: Gironell
authors.forename: L
authors.initials: L
authors.lastname: Rami
authors.forename: J
authors.initials: J
authors.lastname: Kulisevsky
authors.forename: C
authors.initials: C
authors.lastname: García-Sánchez
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation