title: Plasma carotene and alpha-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA).
abstract: BACKGROUND
  Only a few observational studies have related plasma carotene and alpha-tocopherol to mortality in elderly subjects.
  
  
  OBJECTIVE
  The objective was to study the association of plasma carotene (alpha-and beta-carotene) and alpha-tocopherol with all-cause and cause-specific mortality in elderly subjects who participated in a European prospective study.
  
  
  METHODS
  Plasma concentrations of carotene and alpha-tocopherol were measured in 1168 elderly men and women. After a follow-up period of 10 y, 388 persons had died. The association between plasma antioxidants and mortality was analyzed by using Cox proportional hazard models. To put our results in context, we performed a meta-analysis of 5 studies on plasma antioxidants and all-cause mortality in elderly populations.
  
  
  RESULTS
  Plasma carotene concentrations were associated with a lower mortality risk [adjusted rate ratio (RR) for an increment of 0.39 micromol/L: 0.79; 95% CI: 0.70, 0.89]. This lower mortality risk was observed for both cancer (RR: 0.59; 95% CI: 0.44, 0.79) and cardiovascular disease (RR: 0.83; 95% CI: 0.70, 1.00). The lower risk of cardiovascular death was confined to those with a body mass index (in kg/m2) <25 (RR: 0.67; 95% CI: 0.49, 0.94). Plasma concentrations of alpha-tocopherol were not associated with all-cause or cause-specific mortality. The results for both plasma antioxidants and all-cause mortality were confirmed by the meta-analysis.
  
  
  CONCLUSIONS
  This prospective study suggests that high plasma concentrations of carotene are associated both with lower mortality from all causes and with cancer in the elderly. For cardiovascular mortality, the inverse association was confined to elderly with body mass indexes <25.
authors.affiliation: Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands. brian.buijsse@rivm.nl
authors.forename: Brian
authors.initials: B
authors.lastname: Buijsse
authors.forename: Edith J M
authors.initials: EJ
authors.lastname: Feskens
authors.forename: Daniela
authors.initials: D
authors.lastname: Schlettwein-Gsell
authors.forename: Monique
authors.initials: M
authors.lastname: Ferry
authors.forename: Frans J
authors.initials: FJ
authors.lastname: Kok
authors.forename: Daan
authors.initials: D
authors.lastname: Kromhout
authors.forename: Lisette C P G M
authors.initials: LC
authors.lastname: de Groot
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000401:mortality*; D002338:Carotenoids / Q000097:blood*; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008019:Life Style; D008297:Male; D015201:Meta-Analysis as Topic; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality*; D009752:Nutritional Status; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011446:Prospective Studies; D024502:alpha-Tocopherol / Q000097:blood*; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D002338:Carotenoids; D024502:alpha-Tocopherol