title: Vancomycin versus teicoplanin in the therapy of experimental methicillin-resistant Staphylococcus aureus (MRSA) meningitis.
abstract: The aim of this study was to compare the antibacterial activity of teicoplanin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis using a rabbit meningitis model. The MRSA strain ATCC 43300 was used to infect the rabbits. The vancomycin group received 20 mg/kg vancomycin every 12h (q12h), the teicoplanin group received 6 mg/kg teicoplanin q12h and the control group did not receive any treatment. Drug levels were measured using a bioassay technique. Bacterial counts in the treatment groups were significantly lower (P<0.05) than those of the control group at 12 h and 24 h after treatment. When the treatment groups were compared, the bacterial counts after 12 h or 24 h of treatment were similar (P>0.05). These data suggest that the antibacterial activity of vancomycin and teicoplanin are similar in experimental MRSA meningitis of rabbits.
authors.affiliation: Ege University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, 35100 Bornova, Izmir, Turkey. sipahio@med.ege.edu.tr
authors.forename: Oguz Resat
authors.initials: OR
authors.lastname: Sipahi
authors.forename: Bilgin
authors.initials: B
authors.lastname: Arda
authors.forename: Taskin
authors.initials: T
authors.lastname: Yurtseven
authors.forename: Hilal
authors.initials: H
authors.lastname: Sipahi
authors.forename: Erkin
authors.initials: E
authors.lastname: Ozgiray
authors.forename: Bedia Mutay
authors.initials: BM
authors.lastname: Suntur
authors.forename: Sercan
authors.initials: S
authors.lastname: Ulusoy
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D016106:Methicillin Resistance; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification; D017334:Teicoplanin / Q000627:therapeutic use*; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin