title: Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.
abstract: The vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic mediators related to inflammation-associated synovial angiogenesis. The aim of this study was to asses the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants with rheumatoid arthritis (RA). The population under study was composed of a total of 753 unrelated RA patients and 801 healthy controls. The VEGF -1154 G-->A and -634 G-->C polymorphism genotyping was performed by real-time polymerase chain reaction technology, using TaqMan 5' allelic discrimination assay. No evidence of association was observed between the -1154 G-->A and the -634 G-->C VEGF polymorphisms, or inferred VEGF haplotypes with RA susceptibility or clinical manifestations. Our results suggest that the analyzed VEGF promoter polymorphisms may not play a relevant role in RA pathogenesis in our population.
authors.affiliation: Instituto de Parasitología y Biomedicina, Granada, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Rueda
authors.forename: M Angel
authors.initials: MA
authors.lastname: González-Gay
authors.forename: M Angel
authors.initials: MA
authors.lastname: López-Nevot
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Arquero
authors.forename: Alejandro
authors.initials: A
authors.lastname: Balsa
authors.forename: J Luis
authors.initials: JL
authors.lastname: Pablos
authors.forename: Dora
authors.initials: D
authors.lastname: Pascual-Salcedo
authors.forename: Emilio Gómez
authors.initials: EG
authors.lastname: de la Concha
authors.forename: M Francisca
authors.initials: MF
authors.lastname: González-Escribano
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
mesh_terms: D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012217:Rheumatoid Factor / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004247:DNA; D012217:Rheumatoid Factor