title: Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials.
abstract: In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.
authors.affiliation: Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
authors.forename: Shengfu
authors.initials: S
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Lingyan
authors.initials: L
authors.lastname: Li
authors.forename: Shaoyi
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000327:Adsorption; D000818:Animals; D002417:Cattle; D006023:Glycoproteins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D018625:Microscopy, Atomic Force / Q000379:methods; D015394:Molecular Structure; D010316:Particle Size; D010767:Phosphorylcholine / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D055672:Static Electricity; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors
chemical_list: D006023:Glycoproteins; D013438:Sulfhydryl Compounds; D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; D006046:Gold