title: The relationship between restrictive and repetitive behaviors in individuals with autism and obsessive compulsive symptoms in parents.
abstract: This study investigated the relationship between repetitive behaviors in individuals with autism and obsessive-compulsive behaviors in parents. We hypothesized that repetitive behaviors in probands with autism would be associated with increased obsessive-compulsive behaviors in parents in sporadic families (1 known case of autism per family and no known history of autism). Parents with clinically significant Y-BOCS scores were more likely to have a family history of obsessive-compulsive disorder. The empirically derived Autism Diagnostic Interview-R (ADI-R) factor, Insistence on Sameness, was positively correlated with obsessive-compulsive behaviors in parents. Further, when probands were grouped on the basis of parental Y-BOCS scores (clinically significant versus non-clinically significant), probands whose parents had clinically significant Y-BOCS scores had higher ADI-R Insistence on Sameness factor scores. The findings of the current study of sporadic families extend previous work that has shown an association between restrictive/repetitive behaviors in probands with autism and obsessive-compulsive features in parents.
authors.affiliation: W.S. Hall Psychiatric Institute, University of South Carolina, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Abramson
authors.forename: S A
authors.initials: SA
authors.lastname: Ravan
authors.forename: H H
authors.initials: HH
authors.lastname: Wright
authors.forename: K
authors.initials: K
authors.lastname: Wieduwilt
authors.forename: C M
authors.initials: CM
authors.lastname: Wolpert
authors.forename: S A
authors.initials: SA
authors.lastname: Donnelly
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: M L
authors.initials: ML
authors.lastname: Cuccaro
mesh_terms: D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology*; D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D005190:Family / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology* / Q000523:psychology*; D010290:Parents / Q000523:psychology*; D010507:Periodicity; D010641:Phenotype; D019956:Stereotypic Movement Disorder / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires