Optical coherence tomography findings in tamoxifen retinopathy.
OBJECTIVE
To describe optical coherence tomography (OCT) findings in two cases of typical tamoxifen retinopathy.


METHODS
Observational cases report.


METHODS
Two patients with tamoxifen retinopathy were imaged with fluorescein angiography and OCT 3.


RESULTS
Fluorescein angiography showed foveolar hyperfluorescence. OCT revealed a foveolar cystoid space with focal disruption of the photoreceptor line. There was no evidence of macular edema or thickening.


CONCLUSIONS
In both cases, OCT findings are not consistent with previous descriptions of tamoxifen retinopathy, based on fundus examination and fluorescein angiography, which include a description of macular edema. This new imaging suggests that tamoxifen maculopathy may include a foveolar cystoid space different from macular edema.
Gualino
Vincent
V
Department of Ophthalmology, Hôpital Lariboisiĕre, Assistance Publique-Hôpitaux de Paris, Université Paris #7, Paris, France.
Cohen
Salomon Y
SY
Delyfer
Marie-Noëlle
MN
Sahel
José-Alain
JA
Gaudric
Alain
A
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008875:Middle Aged; D012160:Retina / Q000187:drug effects / Q000473:pathology*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D013629:Tamoxifen / Q000009:adverse effects*; D041623:Tomography, Optical Coherence
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen