Effects of multiple pulmonary aspirations of enteral solutions on lung tissue damage.
OBJECTIVE
The aim of this study was to compare the pulmonary histopathologic effects of enteral solutions with various lipid content, after multiple aspirations in rats.


METHODS
Thirty Wistar albino rats were randomly assigned to one of three groups (n = 10). Saline solution (0.9%) (group C, control), Impact (lipid content, 28 g/l; group I), Pulmocare (lipid content, 93.3g/l; group P) were injected into the lung through the trachea, in a volume of 0.8 ml/kg. The aspiration procedure was performed three times in total, in every 2 days. After seven days from the first aspiration, rats were killed, and lungs were examined for histopathologic examination.


RESULTS
Alveolar histiocytes were statistically higher in left lungs of the group I than the left ones of the control group (P < 0.05). Lipid-laden alveolar macrophages were significantly higher in left lungs of groups I and, P than left lungs of the control group (P<0.05).


CONCLUSIONS
Lung tissue damage occurring after multiple pulmonary aspirations of Impact and Pulmocare, is histopathologically similar to each other, and is in the form of lipoid pneumonia. In cases of multiple pulmonary aspirations, volume of the aspirate and chronicity of the aspiration look like major impact factors rather than the amount of the lipid.
Umuroğlu
Tümay
T
Department of Anesthesiology and Reanimation, Marmara University, Tophanelioğlu cad., Yurtacon sok, Istanbul, Turkey. tans6@hotmail.com
Takil
Arzu
A
Irmak
Pinar
P
Yildizeli
Bedrettin
B
Ahiskali
Rengin
R
Doğan
Varlik
V
Göğüş
F Yilmaz
FY
D000818:Animals; D004750:Enteral Nutrition / Q000009:adverse effects*; D005223:Fats / Q000009:adverse effects / Q000032:analysis; D005260:Female; D005526:Food, Formulated / Q000009:adverse effects / Q000032:analysis; D006644:Histiocytes / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D011015:Pneumonia, Aspiration / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D005223:Fats