Interspecies transmission of chronic wasting disease prions to squirrel monkeys (Saimiri sciureus).
Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.
Marsh
Richard F
RF
Department of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Kincaid
Anthony E
AE
Bessen
Richard A
RA
Bartz
Jason C
JC
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D018562:Disease Transmission, Infectious; D008992:Monkey Diseases / Q000473:pathology / Q000635:transmission*; D018620:PrPSc Proteins / Q000378:metabolism; D012453:Saimiri; D013045:Species Specificity; D034081:Wasting Disease, Chronic / Q000473:pathology / Q000635:transmission*
D018620:PrPSc Proteins