Dibutyl phthalate, an alpha-glucosidase inhibitor from Streptomyces melanosporofaciens.
Dibutyl phthalate was found to inhibit alpha-glucosidase, alpha- and beta-mannosidases and beta-glucosidase, in that order of inhibition strength. Dibutyl phthalate was shown to be a reversible, slow-binding, noncompetitive inhibitor of yeast alpha-glucosidase with a K(i) value of 3.9 microM.
Lee
D S
DS
Department of Microbiology, College of Natural Science, Kyungpook National University, Taegu 702-701, Korea.