title: Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats.
abstract: This paper reports the efficacy of emodepside/praziquantel spot-on (Profender), Bayer AG, Leverkusen, Germany), a novel broad-spectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/praziquantel spot-on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/praziquantel spot-on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/praziquantel spot-on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations.
authors.affiliation: Bayer HealthCare AG, Animal Health Division, R&D Parasiticides, 51368, Leverkusen, Germany. gertraut.altreuther@bayerhealthcare.com.
authors.forename: G
authors.initials: G
authors.lastname: Altreuther
authors.affiliation: Animal Sciences Group, Wageningen UR, Division of Infectious Diseases, 8200, AB Lelystad, The Netherlands.
authors.forename: F H M
authors.initials: FHM
authors.lastname: Borgsteede
authors.affiliation: Bayer HealthCare LCC, Animal Health Division, Kansas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Buch
authors.affiliation: Bayer HealthCare LCC, Animal Health Division, Kansas, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Charles
authors.affiliation: Professional Laboratory and Research Services, Corapeake, NC 27926, USA.
authors.forename: L
authors.initials: L
authors.lastname: Cruthers
authors.affiliation: Institute of Parasitology, University of Veterinary Medicine, 30559, Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Epe
authors.affiliation: Young Veterinary Research Services, Turlock, CA 95380, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Young
authors.affiliation: Bayer HealthCare AG, Animal Health Division, R&D Parasiticides, 51368, Leverkusen, Germany.
authors.forename: K J
authors.initials: KJ
authors.lastname: Krieger
mesh_terms: D000287:Administration, Topical; D000722:Ancylostoma / Q000187:drug effects; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D047630:Depsipeptides / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D011223:Praziquantel / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D011223:Praziquantel; C468987:emodepside