title: Radiation-induced capsule tissue reactions around textured breast implants in a rat model.
abstract: Capsule fibrosis and other complications around various filled breast implants were evaluated in a rat radiation model after 12 months of implantation. Model implants, one per rat, were implanted subcutaneously. One month after subcutaneous implantation, high voltage radiation followed one half each group. A higher rate of capsule fibrosis occurred in radiated animals. Malignant tumors at the implantation site developed in 40% of radiated and 24% of non-radiated animals, with a much higher rate of mitosis in the radiated group (Mann-Whitney, P=0.008). The presence of an implant is a cofactor for tumor development in rats (chi2-test, chi2=6.927; P=0.008) as well as radiation, since none of the control animals developed tumors. Applied to humans, capsule contracture (fibrosis) is a common complication of radiation, while development of radiation-induced sarcoma is a rare complication after postoperative radiotherapy by all account. Still further long-term follow-up human studies are necessary.
authors.affiliation: Institute of Pathology, University of Muenster, Domagkstr. 17, 48149 Muenster FRG, Germany. eltze@uni-muenster.de
authors.forename: E
authors.initials: E
authors.lastname: Eltze
authors.forename: U
authors.initials: U
authors.lastname: Schäfer
authors.forename: O
authors.initials: O
authors.lastname: Bettendorf
authors.forename: A
authors.initials: A
authors.lastname: Rody
authors.forename: F
authors.initials: F
authors.lastname: Herchenröder
authors.forename: T
authors.initials: T
authors.lastname: Chiwritsch
authors.forename: C
authors.initials: C
authors.lastname: Jackisch
authors.forename: B
authors.initials: B
authors.lastname: Pfleiderer
mesh_terms: D000818:Animals; D018427:Breast Implants / Q000009:adverse effects*; D003286:Contracture / Q000473:pathology*; D005354:Fibrosarcoma / Q000532:radiotherapy* / Q000601:surgery*; D005355:Fibrosis; D005549:Foreign-Body Reaction / Q000209:etiology*; D007150:Immunohistochemistry; D008297:Male; D023421:Models, Animal; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D011474:Prosthesis Design; D011878:Radiotherapy / Q000009:adverse effects; D051381:Rats; D017207:Rats, Sprague-Dawley