title: Cell cycle: how cyclin E got its groove back.
abstract: CDK1 has long been known to orchestrate the passage of mammalian cells into and through mitosis. Recent work revisits the idea that CDK1, in conjunction with cyclin E, participates in S-phase entry as well. The new results shed light on a recent cell-cycle mystery, and provide another dramatic example of apparent functional redundancy among cyclins and cyclin-dependent kinases.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
authors.forename: Markus
authors.initials: M
authors.lastname: Welcker
authors.forename: Bruce
authors.initials: B
authors.lastname: Clurman
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D019927:Cyclin E / Q000378:metabolism*; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D016196:S Phase / Q000502:physiology*; D015003:Yeasts
chemical_list: D019927:Cyclin E; D016203:CDC2 Protein Kinase; D051357:Cyclin-Dependent Kinase 2