Morphometry of pseudoepitheliomatous hyperplasia: objective comparison to normal and dysplastic oral mucosae.
OBJECTIVE
To compare the architectural and morphometric features of pseudoepitheliomatous hyperplasia (PEH) associated with oral granular cell tumors (GCT), normal oral mucosa and oral epithelial dysplasia.


METHODS
Quantitative comparisons between the diagnostic entities were carried out at the tissue level by estimating the fractal complexity of the epithelial connective tissue interface and at the cellular level by analyzing the morphometric features of algorithmically segmented epithelial cell areas.


RESULTS
Casewise multivariate analysis showed that the fractal properties produced a correct discrimination rate of 96.4% between PEH and normal mucosa. Cellular parameters gave a 100% correct discrimination rate between PEH and mild dysplasia. Combining the fractal and cellular properties also showed 100% discrimination between PEH and normal mucosa and between PEH and mild dysplasia.


CONCLUSIONS
The results show that PEH associated with GCT displays quantifiable morphometric features that make it differentiable from normal oral mucosa and oral epithelial dysplasia.
Abu Eid
Rasha
R
Oral Pathology Unit, School of Dentistry, University of Birmingham, St. Chad's Queensway, B4 6NN Birmingham, United Kingdom. r.f.abueid.1@bham.ac.uk
Landini
Gabriel
G
D000328:Adult; D003937:Diagnosis, Differential; D016586:Granular Cell Tumor / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology* / Q000473:pathology* / Q000648:ultrastructure; D015999:Multivariate Analysis