title: Survival probability of diffusion with trapping in cellular neurobiology.
abstract: The problem of diffusion with absorption and trapping sites arises in the theory of molecular signaling inside and on the membranes of biological cells. In particular, this problem arises in the case of spine-dendrite communication, where the number of calcium ions, modeled as random particles, is regulated across the spine microstructure by pumps, which play the role of killing sites, while the end of the dendritic shaft is an absorbing boundary. We develop a general mathematical framework for diffusion in the presence of absorption and killing sites and apply it to the computation of the time-dependent survival probability of ions. We also compute the ratio of the number of absorbed particles at a specific location to the number of killed particles. We show that the ratio depends on the distribution of killing sites. The biological consequence is that the position of the pumps regulates the fraction of calcium ions that reach the dendrite.
authors.affiliation: Department of Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Holcman
authors.forename: Avi
authors.initials: A
authors.lastname: Marchewka
authors.forename: Zeev
authors.initials: Z
authors.lastname: Schuss
mesh_terms: D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism*; D002470:Cell Survival; D003198:Computer Simulation; D003712:Dendrites / Q000737:chemistry / Q000502:physiology*; D004058:Diffusion; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D008959:Models, Neurological; D015233:Models, Statistical; D009446:Neurobiology / Q000379:methods; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000378:metabolism*; D013569:Synapses / Q000737:chemistry / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents; D002118:Calcium