title: Evaluation of the efficacy of emodepside+praziquantel topical solution against cestode (Dipylidium caninum, Taenia taeniaeformis, and Echinococcus multilocularis) infections in cats.
abstract: Emodepside+praziquantel topical solution was developed to provide broad-spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender, BayerAG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo-controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5- 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections.
authors.affiliation: Bayer HealthCare LLC, Animal Health Division, Kansas, USA. sam.charles.b@bayer.com.
authors.forename: S D
authors.initials: SD
authors.lastname: Charles
authors.affiliation: Bayer HealthCare AG, Animal Health Division, R&D Parasiticides, 51368, Leverkusen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Altreuther
authors.affiliation: East Tennessee Clinical Research, Knoxville, Tennessee, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Reinemeyer
authors.affiliation: Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
authors.forename: J
authors.initials: J
authors.lastname: Buch
authors.affiliation: Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
authors.forename: T
authors.initials: T
authors.lastname: Settje
authors.affiliation: Professional Laboratory Research Services, North Carolina, USA.
authors.forename: L
authors.initials: L
authors.lastname: Cruthers
authors.affiliation: ClinVet International, Bloemfontein, South Africa.
authors.forename: D J
authors.initials: DJ
authors.lastname: Kok
authors.affiliation: Cheri Hill Kennel R & D, Michigan, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Bowman
authors.affiliation: Cheri Hill Kennel R & D, Michigan, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Kazacos
authors.affiliation: School of Botany & Zoology, Faculty of Medicine, Australian National University, Canberra, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Jenkins
authors.affiliation: Freie Universität Berlin, Institute for Parasitology and International Animal Health, Berlin, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Schein
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D002589:Cestoda / Q000187:drug effects; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D047630:Depsipeptides / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D011223:Praziquantel / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D047630:Depsipeptides; D011223:Praziquantel; C468987:emodepside