title: Heart block and empirical therapy after transcatheter closure of perimembranous ventricular septal defect.
abstract: Two patients with perimembranous ventricular septal defects (VSDs) and inlet extension have undergone uncomplicated transcatheter device closure using the Amplatzer membranous VSD device. Both patients developed complete heart block 2-4 days from the closure. Both patients responded well to high-dose intravenous therapy with steroids and high-dose oral anti-inflammatory aspirin. Both patients remain in normal sinus rhythm 8 weeks and 10 months, respectively, from the episode.
authors.affiliation: Pediatric Cardiology Service, Gleneagles Hospital, Singapore.
authors.forename: William C L
authors.initials: WC
authors.lastname: Yip
authors.forename: Frank
authors.initials: F
authors.lastname: Zimmerman
authors.forename: Ziyad M
authors.initials: ZM
authors.lastname: Hijazi
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D006328:Cardiac Catheterization / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006327:Heart Block / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007223:Infant; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin