title: SYNGR1 is associated with schizophrenia and bipolar disorder in southern India.
abstract: Chromosome 22q11-13 is one of the most consistent linkage regions for schizophrenia (SCZ) and bipolar disorder (BPAD). The SYNGR1 gene, which is associated with presynaptic vesicles in neuronal cells, is located on 22q13.1. We have previously identified a novel nonsense mutation in the SYNGR1 gene in a SCZ pedigree. In the present study, a detailed analysis of this gene was performed in a case-control cohort (198 BPAD, 193 SCZ and 107 controls from southern India) to test for association with SCZ and BPAD. Sequence analysis of all exonic and flanking intronic regions of the SYNGR1 gene in 198 BPAD and 193 SCZ cases revealed a novel mutation Lsy99Glu (in one BPAD patient) and two other novel common polymorphisms [synonymous single nucleotide polymorphism (SNP--Ser97Ser) and an Asn ins/del] in the SYNGR1 gene. We also validated 9 out of 14 dbSNPs in our population. Case-control analysis revealed allelic (P = 0.028-0.00007) association of five polymorphisms with SCZ and/or BPAD cases. Further, 3-SNP (with LD block 1 SNPs) and 2-SNP (with LD block 2 SNPs) haplotype analyses did not show any association with either SCZ or BPAD. Our results support SYNGR1 as a probable susceptibility gene for SCZ and BPAD. Also, the observed association of SYNGR1 with both SCZ and BPAD suggests the likely involvement of a common pathway in the etiology of these disorders.
authors.affiliation: Functional Genomics Unit, Institute of Genomics and Integrative Biology (CSIR), Delhi University Campus, Mall Road, Delhi, 110007, India.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Verma
authors.forename: Shobana
authors.initials: S
authors.lastname: Kubendran
authors.forename: Swapan Kumar
authors.initials: SK
authors.lastname: Das
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Jain
authors.forename: Samir K
authors.initials: SK
authors.lastname: Brahmachari
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007194:India / Q000453:epidemiology; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D017422:Sequence Analysis, DNA; D062805:Synaptogyrins
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C507923:SYNGR1 protein, human; D062805:Synaptogyrins