Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection.
OBJECTIVE
To investigate the presence of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection.


METHODS
HBsAg and HBcAg were examined in ovarian biopsy tissues from 26 patients with HBV infection by immunocytochemistry, and HBV DNA was detected in ovarian tissues by PCR.


RESULTS
HBsAg and HBcAg were present with the same positive rate of 34.6% (9/26). The total positive rate was 46.2% (12/26). HBsAg and HBcAg were positive in 6 (23.1%) of the 26 patients. Brown positive particles were diffusely distributed in ovarian cells. The positive rate of HBV DNA was 58.3% (7/12).


CONCLUSIONS
HBsAg, HBcAg, and HBV DNA can be detected in ovarian tissues from patients with HBV infection. The presence of HBsAg and HBcAg in ovarian tissues does not correlate with the HBV markers in serum.
Chen
Li-Zhang
LZ
School of Public Health, Central South University, Changsha 410078, Hunan Province, China. chenliz@mail.csu.edu.cn
Fan
Xue-Gong
XG
Gao
Jian-Ming
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D005260:Female; D006509:Hepatitis B / Q000821:virology*; D006512:Hepatitis B Core Antigens / Q000378:metabolism; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008875:Middle Aged; D010053:Ovary / Q000821:virology*
D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens