[Alcoholic and nonalcoholic steatohepatitis: the same disease! II. Management].
Both alcoholic and non-alcoholic steatohepatitis share common histological findings and the risk of developing cirrhosis. Liver biopsy is required for the diagnosis, and the aim of treatment is to prevent cirrhosis. In alcoholic steatohepatitis, abstinence from alcohol is associated to prednisone in a severe form, as defined by a Maddrey's score > 32. Due to common pathogenic mechanisms, we recommend that coexisting metabolic alterations that are commonly observed in non-alcoholic steatohepatitis should also be treated in alcoholics. Thus, weight reduction, physical exercise, improvement of insulin sensitivity and reduction of oxidative stress, all may be beneficial both in alcoholic and non-alcoholic steatohepatitis.
Spahr
L
L
Service de gastroentérologie et d'hépatologie Hôpitaux universitaires de Genève. Laurent.Spahr@hcuge.ch
Hadengue
A
A
D000428:Alcohol Drinking; D000975:Antioxidants / Q000627:therapeutic use; D050171:Dyslipidemias / Q000517:prevention & control; D015444:Exercise; D005234:Fatty Liver / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000502:physiology; D018384:Oxidative Stress; D015431:Weight Loss
D000975:Antioxidants; D007328:Insulin