title: A formal synthesis of (+)-lactacystin.
abstract: A synthetic route to the neurotrophic agent (+)-lactacystin has been developed utilizing a base-promoted intramolecular alkylidenecarbene C-H insertion as the key transformation.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, IL, USA. wardropd@uic.edu
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Wardrop
authors.forename: Edward G
authors.initials: EG
authors.lastname: Bowen
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000478:Alkylation; D006838:Hydrocarbons / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry
chemical_list: D006838:Hydrocarbons; D011758:Pyrroles; C067713:lactacystin; C030011:carbene; C013231:pyrroline; D008697:Methane; D000111:Acetylcysteine