title: Fermented mushroom milk-supplemented dietary fibre prevents the onset of obesity and hypertriglyceridaemia in Otsuka Long-Evans Tokushima fatty rats.
abstract: OBJECTIVE
  Fermented milk product containing edible mushroom water extracts (mushroom yogurt; MY) has been reported to have glycaemic control and triglyceride-lowering effects in streptozotocin (STZ)-induced diabetic rats and Zucker diabetic fatty (ZDF) rats. Here, we investigated how MY-supplemented dietary fibre (10 and 20%, v/w) influences the onset of obesity and hypertriglyceridaemia in Otsuka Long-Evans Tokushima fatty (OLETF) rats.
  
  
  METHODS
  The OLETF rats were fed a powdered chow diet supplemented with MY at the levels of 10 (v/w) and 20% for 6 weeks from 10 weeks of age, but the OLETF control rats were not supplemented. Their weight, fat distribution and lipid profile have been determined.
  
  
  RESULTS
  The body weights in MY-fed rats were reduced compared with the control rats. The perirenal fat was decreased in both MY groups, but the visceral and epididymal fats reduced only in the MY 20% group. The concentrations of serum triglyceride and non-esterified fatty acid in MY-fed rats were decreased in a dose-dependent manner. However, the levels of other serum lipid profiles [total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol] were comparable among all rats.
  
  
  CONCLUSIONS
  Anti-obesity and triglyceride lowering by MY-supplemented dietary fibre in OLETF rats might have resulted from the synergistic effect of components in the fermented mushroom-milk product.
authors.affiliation: BioHub Co., Ltd, Gyeongsang National University, Jinju, Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Jeon
authors.forename: J W
authors.initials: JW
authors.lastname: Park
authors.forename: B K
authors.initials: BK
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: T S
authors.initials: TS
authors.lastname: Jung
authors.forename: J R
authors.initials: JR
authors.lastname: Hahm
authors.forename: D R
authors.initials: DR
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
authors.forename: J Y
authors.initials: JY
authors.lastname: Cha
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000363:Agaricales; D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use; D004043:Dietary Fiber / Q000627:therapeutic use; D015228:Hypertriglyceridemia / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D020334:Rats, Inbred OLETF; D015430:Weight Gain / Q000187:drug effects; D015014:Yogurt
chemical_list: D019440:Anti-Obesity Agents; D004043:Dietary Fiber; D008055:Lipids; D010936:Plant Extracts