Evaluation of the Brighton Collaboration case definition of acute intussusception during active surveillance.
To evaluate the Brighton Collaboration case definition of acute intussusception, we reviewed all episodes reported to the Swiss Paediatric Surveillance Unit (SPSU) during 1 year (4/2003--3/2004). Of 96 confirmed episodes 86 (90%, 95% CI 83--96) were captured by the case definition. Of the remaining 10 episodes, 9 resolved spontaneously following presentation with clinical signs and symptoms, and ultrasound findings compatible with intussusception. Eighty-two episodes met level 1 of the definition, the highest level of diagnostic certainty. Compared to level 1, the sensitivity of level 2 (intermediate level) and level 3 (lowest level) was 65% (CI 55--74) and 30% (CI 20--40), respectively. In conclusion, the case definition was useful and applicable to assess the background rate of intussusception in the light of potential future rotavirus immunization.
Tapiainen
Terhi
T
University Children Hospital, Division of Pediatrics Infectious Diseases and Vaccines, Post Box, 4005 Basel, Switzerland.
Bär
Gurli
G
Bonhoeffer
Jan
J
Heininger
Ulrich
U
D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D013557:Switzerland; D014611:Vaccination / Q000009:adverse effects