Transient serous retinal detachment in classic and occult choroidal neovascularization after photodynamic therapy.
OBJECTIVE
To quantify transient serous retinal detachment in classic and occult choroidal neovascularization (CNV) after photodynamic therapy (PDT).


METHODS
Prospective consecutive case series.


METHODS
Consecutive patients with classic and occult CNV were examined by optical coherence tomography before PDT and at 2 and 7 days after PDT.


RESULTS
In classic CNV (n = 6), retinal elevations increased from 217 (SD 42) microm before PDT to 626 (SD 157) microm 2 days after PDT and decreased to 240 (SD 36) microm 7 days after treatment. In occult CNV (n = 4), the mean retinal elevation of 266 (SD 41) microm before PDT increased to 544 (SD 94) microm 2 days after PDT and decreased to 259 (SD 40) microm 7 days after treatment.


CONCLUSIONS
Cross-sectional optical coherence tomography imaging revealed transient subretinal fluid accumulation in classic as well as in occult CNV after PDT. The subretinal location possibly relates to an outer blood-retinal barrier breakdown after PDT.
Mennel
Stefan
S
Department of Ophthalmology, Philipps-University, Marburg, Germany. stefan.mennel@lycos.com
Meyer
Carsten H
CH
Eggarter
Fred
F
Peter
Silvia
S
D001813:Blood-Retinal Barrier; D020256:Choroidal Neovascularization / Q000188:drug therapy*; D005122:Exudates and Transudates; D006801:Humans; D010778:Photochemotherapy; D011183:Postoperative Complications; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology*; D044967:Serum; D041623:Tomography, Optical Coherence / Q000379:methods