title: Fusariotoxin transfer in animal.
abstract: Mycotoxin fusariotoxins, essentially represented by trichothecenes, zearalenone and fumonisins, are widely scattered in cereals and their products. Human and animals are particularly concerned by toxicity consecutive to oral chronic exposure. Human exposure can be direct via cereals or indirect via products of animals having eaten contaminated feed. As this alimentary risk is considered as a major problem in public health, it is thus of great importance to determine bioavailability, metabolic pathways and distribution of these mycotoxins in animal and human organism. Most studies indicate that fusariotoxins can be rapidly absorbed in the small intestine but the mechanisms involved remain unclear. Except NIV, fusariotoxins can be partly metabolised into more hydrophilic molecules in digestive tract or liver. Fumonisins present different behaviour as they seem very few and slowly absorbed and metabolised. The main part of absorbed fusariotoxins shows a rapid elimination within 24h after ingestion, followed by a slower excretion of small amounts. However, traces of fusariotoxins or their derivates can be found in animal products. This manuscript, reviewing literature published on fusariotoxin transfer, highlights that too little data are available to correctly appreciate fusariotoxin transfer in organism. Further studies focusing on mechanisms involved in the transfer are needed before clarifying risk assessment for human health.
authors.affiliation: UMR INRA-DGER Métabolisme et Toxicologie Comparée des Xénobiotiques, Ecole Nationale Vétérinaire de Lyon, Marcy l'Etoile, France. cavret@isara.fr
authors.forename: S
authors.initials: S
authors.lastname: Cavret
authors.forename: S
authors.initials: S
authors.lastname: Lecoeur
mesh_terms: D000818:Animals; D001682:Biological Availability; D003257:Consumer Product Safety; D002523:Edible Grain / Q000737:chemistry*; D005243:Feces / Q000737:chemistry; D005506:Food Contamination; D006801:Humans; D007408:Intestinal Absorption; D008892:Milk / Q000737:chemistry; D011634:Public Health; D018570:Risk Assessment; D013045:Species Specificity; D013605:T-2 Toxin / Q000378:metabolism / Q000493:pharmacokinetics*; D016482:Urinalysis
chemical_list: D013605:T-2 Toxin