title: Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia.
abstract: Acquired Glanzmann's thrombasthenia is an uncommon event in association with leukemia. The authors describe a patient with acute lymphoblastic leukemia (ALL) who presented with severe hemorrhagic syndrome, without disseminated intravascular coagulation. The patient's course was complicated by the occurrence of severe hemorrhagic episodes, with a thrombasthenia-like profile, requiring multiple transfusions with packed red cells, platelets, and fresh-frozen plasma. Biological explorations detected anti-GPIIb/IIIa complex antibodies. The patient finally died with refractory disease and persistent bleeding. This case is the first reported of autoantibodies to GPIIb/IIIa in ALL. Such paraneoplastic syndrome is potentially responsible for severe life-threatening hemorrhage.
authors.affiliation: Hospices Civils de Lyon, Hôpital Debrousse, Service d'Onco-Hématologie Pédiatrique, Lyon, France. eli.jm@club-internet.fr
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: André
authors.forename: Claire
authors.initials: C
authors.lastname: Galambrun
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Trzeciak
authors.forename: Yesim
authors.initials: Y
authors.lastname: Dargaud
authors.forename: Cécile
authors.initials: C
authors.lastname: Kaplan-Gouet
authors.forename: Vincent
authors.initials: V
authors.lastname: Jallu
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D016913:Blood Component Transfusion; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000276:immunology / Q000628:therapy; D013915:Thrombasthenia / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D017211:Treatment Failure
chemical_list: D001323:Autoantibodies; D019039:Platelet Glycoprotein GPIIb-IIIa Complex