title: Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer.
abstract: In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita 565-0871, Japan.
authors.forename: Zhioxiong
authors.initials: Z
authors.lastname: Wang
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Itoh
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakano
authors.forename: Isamu
authors.initials: I
authors.lastname: Maeda
authors.forename: Fusako
authors.initials: F
authors.lastname: Umeda
authors.forename: Junji
authors.initials: J
authors.lastname: Yamakawa
authors.forename: Masaya
authors.initials: M
authors.lastname: Kawase
authors.forename: Kiyohito
authors.initials: K
authors.lastname: Yag