title: Synthesis and transformation of [difluoro(phenylseleno)methyl]- trimethylsilane.
abstract: [reaction: see text] A novel and efficient strategy was developed to synthesize [difluoro(phenylseleno)methyl]trimethylsilane (PhSeCF(2)TMS, 2), which was further utilized as a nucleophilic difluoromethylating reagent to incorporate the difluoro(phenylseleno)methyl (PhSeCF(2)) group into carbonyl compounds in good yields. The resulting PhSeCF(2)-containing alcohols 3 could be conveniently converted into corresponding difluoromethyl alcohols 4 by a radical deselenylation.
authors.affiliation: College of Chemistry and Chemical Engineering, Donghua University, Shanghai, China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Qin
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Qiu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Yang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Meng
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing