Autoimmune myocarditis and dilated cardiomyopathy: focus on cardiac autoantibodies.
Criteria of organ-specific autoimmunity are fulfilled in a subset of patients with myocarditis/dilated cardiomyopathy (DCM). In particular, circulating heart-reactive autoantibodies are found in patients and symptom-free relatives. These autoantibodies are directed against multiple antigens, some of which are expressed in the heart (organ-specific), others in heart and some skeletal muscle fibres (partially-heart specific) or in heart and skeletal muscle (muscle-specific). Distinct autoantibodies have different frequency in disease and normal controls. Different techniques detect one or more antibodies, thus they cannot be used interchangeably for screening. It is unknown whether the same patients produce more antibodies or different patient groups develop autoimmunity to distinct antigens. IgG antibodies, shown to be cardiac and disease-specific for myocarditis/DCM, can be used as autoimmune markers for identifying patients in whom immunosuppression may be beneficial and relatives at risk. Some autoantibodies may also have a functional role, but further work is needed.
Caforio
A L P
AL
Division of Cardiology, Department of Cardiological, Thoracic and Vascular Sciences, Centro V Gallucci, University of Padova-Policlinico, Padova, Italy. alida.caforio@unipd.it
Daliento
L
L
Angelini
A
A
Bottaro
S
S
Vinci
A
A
Dequal
G
G
Tona
F
F
Iliceto
S
S
Thiene
G
G
McKenna
W J
WJ
D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000502:physiology*; D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D024101:Mitochondrial Proteins / Q000276:immunology; D009205:Myocarditis / Q000276:immunology / Q000503:physiopathology; D043585:Receptor, Muscarinic M2 / Q000276:immunology; D011943:Receptors, Adrenergic, beta / Q000276:immunology; D000254:Sodium-Potassium-Exchanging ATPase / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; D024101:Mitochondrial Proteins; D043585:Receptor, Muscarinic M2; D011943:Receptors, Adrenergic, beta; D000254:Sodium-Potassium-Exchanging ATPase