title: Infection with Fasciola hepatica.
abstract: Fascioliasis, caused by the liver fluke Fasciola hepatica, is an infection that occurs worldwide, although humans are accidental hosts. F. hepatica infection comprises two stages, hepatic and biliary, with different signs and symptoms. Stool examination and ELISA can be used for the initial diagnosis. Radiographic techniques, such as computerised tomography and ultrasonography, as well as magnetic resonance imaging, are used widely for confirmation and follow-up of the disease. Invasive techniques, such as percutaneous cholangiography, endoscopic retrograde cholangiography and liver biopsy, may aid in the diagnosis but are not essential. Triclabendazole is recommended as the first-line agent for the treatment of F. hepatica infection, with bithionol as an alternative.
authors.affiliation: Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey. duyguyaks@yahoo.com
authors.forename: D Y
authors.initials: DY
authors.lastname: Aksoy
authors.forename: U
authors.initials: U
authors.lastname: Kerimoglu
authors.forename: A
authors.initials: A
authors.lastname: Oto
authors.forename: S
authors.initials: S
authors.lastname: Erguven
authors.forename: S
authors.initials: S
authors.lastname: Arslan
authors.forename: S
authors.initials: S
authors.lastname: Unal
authors.forename: F
authors.initials: F
authors.lastname: Batman
authors.forename: Y
authors.initials: Y
authors.lastname: Bayraktar
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D001706:Biopsy; D001735:Bithionol / Q000494:pharmacology / Q000627:therapeutic use; D002758:Cholangiography; D004797:Enzyme-Linked Immunosorbent Assay; D005210:Fasciola hepatica / Q000187:drug effects; D005211:Fascioliasis / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005243:Feces / Q000469:parasitology; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D000077682:Triclabendazole; D014463:Ultrasonography
chemical_list: D000980:Antiplatyhelmintic Agents; D001562:Benzimidazoles; D000077682:Triclabendazole; D001735:Bithionol