title: Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.
abstract: A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse.
authors.affiliation: Gedeon Richter Ltd., Budapest, 10. PO Box 27, H-1475, Hungary. i.borza@richter.hu
authors.forename: István
authors.initials: I
authors.lastname: Borza
authors.forename: Sándor
authors.initials: S
authors.lastname: Kolok
authors.forename: Györgyi
authors.initials: G
authors.lastname: Ignácz-Szendrei
authors.forename: István
authors.initials: I
authors.lastname: Greiner
authors.forename: Gábor
authors.initials: G
authors.lastname: Tárkányi
authors.forename: Kornél
authors.initials: K
authors.lastname: Galgóczy
authors.forename: Csilla
authors.initials: C
authors.lastname: Horváth
authors.forename: Sándor
authors.initials: S
authors.lastname: Farkas
authors.forename: György
authors.initials: G
authors.lastname: Domány
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D018929:Cell Culture Techniques; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D016202:N-Methylaspartate / Q000494:pharmacology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
chemical_list: D007093:Imidazoles; D007211:Indoles; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D000620:Aminoimidazole Carboxamide; D016202:N-Methylaspartate; D002118:Calcium