[Effect of nebivolol on parameters of cerebral haemodynamics and 24-hour blood pressure profile in patients with arterial hypertension].
OBJECTIVE
To elucidate effect of nebivolol on parameters of cerebral hemodynamics and 24-hour blood pressure (BP) profile in patients with hypertension.


METHODS
Patients with hypertension of 2nd degree (n=55, age 35-50 years) were divided into 2 groups with similar age, sex, duration of hypertension, and office BP level. Thirty one patients received nebivolol (5-7.5 mg/day), 24 -- atenolol (75-100 mg/day) for 8 weeks.


RESULTS
Nebivolol affected positively 24-hour BP profile (decreased variability and morning increase of BP), improved parameters of cerebral hemodynamics (increased index of cerebrovascular reactivity which reflected the state of adaptation of cerebral arteries). Atenolol exerted similar antihypertensive action but did not alter variability and morning increase of BP. Effect of atenolol on cerebral hemodynamics comprised increases of cerebrovascular reactivity index and vasoconstriction reserve.


CONCLUSIONS
Compared with atenolol nebivolol exerts more favorable effect on 24-hour BP profile and improves cerebral hemodynamics at the account of increased vasodilatation reserve.
Gapon
L I
LI
Prilepova
A A
AA
Tsygol'nik
M D
MD
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D001262:Atenolol / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic
D000319:Adrenergic beta-Antagonists; D001262:Atenolol