title: [Effects of lactone I from Atractylodes macrocephala Koidz on cytokines and proteolysis-inducing factors in cachectic cancer patients].
abstract: OBJECTIVE
  To observe the effect of lactone I from Atractylodes macrocephala Koidz (LAMK I) on the cytokines and proteolysis-inducing factors (PIF) in cachectic cancer patients.
  
  
  METHODS
  Sixty-four cachectic cancer patients were randomized into two groups, namely LAMK I group and FOE (fish oil-enriched nutritional supplementation) treatment group. The appetite, body weight changes, mid-arm muscle circumference (MAMC), and KPS scores were recorded 3 and 7 weeks after the treatment. Immunohistochemistry was used to analyze the changes in the cytokines interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-alpha and Western blotting employed to examine the changes of PIF after the treatment.
  
  
  RESULTS
  The patients' appetite and MAMC in LAMKI group was better than those of patients in FOE group, and the serum IL-1 and TNF-alpha levels and urine PIF level were significantly lower than those of FOE group. Body weight and serum IL-6 level were not significantly different between the two groups.
  
  
  CONCLUSIONS
  Lactone I from Atractylodes macrocephala Koidz can be beneficial for treating cancer cachexia.
authors.affiliation: Department of Traditional Chinese Medicine, First affiliated Hospital of Xian Jiaotong University, Xi'an 710061, China. liuyi.jiaotong@163.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Gen-quan
authors.initials: GQ
authors.lastname: Qiu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Qun-ying
authors.initials: QY
authors.lastname: He
authors.forename: Yun
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D031174:Atractylodes / Q000737:chemistry*; D002100:Cachexia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics; D007783:Lactones / Q000302:isolation & purification / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008517:Phytotherapy; D011509:Proteoglycans / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D007783:Lactones; D011509:Proteoglycans; D014409:Tumor Necrosis Factor-alpha; C042057:proteolysis-inducing peptide