title: Venlafaxine-induced urinary incontinence resolved after switching to sertraline.
abstract: The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine. UI resolved after discontinuation of the drug and did not reappear after switching to sertraline therapy. A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day. Symptoms resolved without consequence 48 hours after discontinuation of venlafaxine. The patient was then treated with sertraline without experiencing any incontinence episodes. Urinary incontinence is an important medical condition with clinical and social implications. Further studies need to be carried out to clarify the pharmacologic differences between dual and selective 5-HT and norepinephrine reuptake inhibitors on lower urinary tract function.
authors.affiliation: Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy. gpolimeni@unime.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Polimeni
authors.forename: Francesco
authors.initials: F
authors.lastname: Salvo
authors.forename: Paola
authors.initials: P
authors.lastname: Cutroneo
authors.forename: Giulio
authors.initials: G
authors.lastname: Nati
authors.forename: Alessandra
authors.initials: A
authors.lastname: Russo
authors.forename: Ettore Saffi
authors.initials: ES
authors.lastname: Giustini
authors.forename: Edoardo
authors.initials: E
authors.lastname: Spina
mesh_terms: D003511:Cyclohexanols / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D012701:Serotonin / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D014549:Urinary Incontinence / Q000139:chemically induced*; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride