Enantioselective construction of quaternary carbon centers by catalytic [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes.
[reaction: see text] The enantioselective [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes using chiral rhodium catalysts gave cycloadducts containing quaternary carbon stereocenters. Both symmetrical and unsymmetrical alkynes and acetylene could be used as coupling partners, and the corresponding bicyclic cyclohexa-1,3-dienes were obtained in good to excellent ee.
Shibata
Takanori
T
Department of Chemistry, School of Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan. tshibata@waseda.jp
Arai
Yoshikazu
Y
Tahara
Yu-Ki
YK