title: HLA-B polymorphism in Japanese HIV-1-infected long-term surviving hemophiliacs.
abstract: Approximately 30% of patients with hemophilia in Japan were infected with human immunodeficiency virus (HIV) in early 1980s through contaminated blood products. In 1995, a cohort of HIV-infected, asymptomatic patients with hemophilia was set up for follow-up study. Although the patients met the criteria for long-term non-progressor (LTNP) at the entry to the cohort, some of them later developed lymphopenia during five more years of observation. We collected blood samples from 80 long-term survivors; 42 of them did not require antiviral therapy, but the rest were under treatment. Analysis of HLA-B genotype revealed that carriers of known HIV-resistant alleles such as HLA-B*5701, B*5801, and alleles of B27 antigenic group were not increased in frequency, but that HLA-B*1507 was increased in the cohort (6.25% vs. 1.03%, OR = 6.40, p = 0.039). We also observed the decrease in carriers of HLA-B*5401 (3.75% vs. 14.95%, OR = 0.22, p = 0.016). HLAB* 5401 is a relatively common allele in East Asian populations and belongs to the same B22 antigenic group as B55 and B56 which were reported to associate with rapid progression. Our data indicated that HLA class I is one of the host factors involved in the retardation of HIV disease progression as also reported in the previous studies; however, the alleles associated with this resistance were not the same because of divergent host genetic background.
authors.affiliation: Department of Microbiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Mwansa
authors.initials: M
authors.lastname: Munkanta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Terunuma
authors.forename: Megumi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Hideji
authors.initials: H
authors.lastname: Hanabusa
authors.forename: Takuma
authors.initials: T
authors.lastname: Miura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Michio
authors.initials: M
authors.lastname: Sakai
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Fujii
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Oka
authors.forename: Juzo
authors.initials: J
authors.lastname: Matsuda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Taki
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Takashima
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Mimaya
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ito
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
authors.forename: Michio
authors.initials: M
authors.lastname: Yasunami
mesh_terms: D000483:Alleles; D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D020276:HIV Long-Term Survivors; D015497:HIV-1; D015235:HLA-B Antigens / Q000235:genetics*; D006467:Hemophilia A / Q000150:complications / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic; D011379:Prognosis
chemical_list: D015235:HLA-B Antigens