title: A new insertion in the HIV-1 reverse transcriptase gene inducing major resistance to non-nucleoside reverse transcriptase inhibitors.
abstract: We identified an HIV-1 isolate with a 3 base pairs insertion in the 100-105 region of the reverse transcriptase gene (RT) along with a G190E and a V75A mutation. Virus carrying the insertion alone or in association with G190A was not infectious. The association of G190E and the 100-105 insertion displayed a high level of resistance to non-nucleoside reverse transcriptase inhibitors; the addition of the insertion to G190E may increase the activity of RT.
authors.affiliation: Virology Laboratory, Hôpital Tenon, Paris, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Amiel
authors.forename: Nathalie
authors.initials: N
authors.lastname: Desire
authors.forename: Veronique
authors.initials: V
authors.lastname: Schneider
authors.forename: Nathalie
authors.initials: N
authors.lastname: Delphin
authors.forename: Ester
authors.initials: E
authors.lastname: Race
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel
authors.forename: Tristan
authors.initials: T
authors.lastname: Piolot
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Dam
authors.forename: Willy
authors.initials: W
authors.lastname: Rozenbaum
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Nicolas
mesh_terms: D004251:DNA Transposable Elements / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*
chemical_list: D004251:DNA Transposable Elements; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase