Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases.
The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities.
Gul
Waseem
W
Department of Pharmacognosy, Pharmacology, Chemistry and Biochemistry and National Center for the Development of Natural Products, The University of Mississippi, Oxford, MS 38655, USA.
Hamann
Mark T
MT
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010272:Parasitic Diseases / Q000188:drug therapy*; D018490:Serotonin Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D001688:Biological Products; D004791:Enzyme Inhibitors; D007211:Indoles; D018696:Neuroprotective Agents; D018490:Serotonin Agents