Enzymatic functionalization of aromatic N-heterocycles: hydroxylation and carboxylation.
Aromatic N-heterocycles are common structural motifs and versatile building blocks for the synthesis of various biologically active compounds. The application of microbial catalysis is considerably advantageous for the synthesis of N-heterocycle derivatives. Recent progress in the microbial functionalization of aromatic N-heterocyclic compounds is reviewed, focusing on the regiospecific hydroxylation and the carboxylation of aromatic N-heterocycles.
Yoshida
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Department of Biomolecular Science, Gifu University, 1-1 Yanagido, Gifu 631-1193, Japan.
Nagasawa
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