title: Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum.
abstract: The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin (1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, 42.3%, respectively.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Sung Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Ki Uk
authors.initials: KU
authors.lastname: Jang
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Chung
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Park
authors.forename: Hee Chol
authors.initials: HC
authors.lastname: Kang
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Yang
authors.forename: Hi Jae
authors.initials: HJ
authors.lastname: Cho
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D012250:Rheum / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000880:Anthraquinones; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013267:Stilbenes