Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting.
Sub-Saharan Africa is disproportionately burdened by intestinal helminth and human immunodeficiency virus (HIV)-1 infection. Recent evidence suggests detrimental immunologic effects from concomitant infection with the two pathogens. Few studies, however, have assessed the prevalence of and predictors for intestinal helminth infection among HIV-1-infected adults in urban African settings where HIV infection rates are highest. We collected and analyzed sociodemographic and parasitologic data from 297 HIV-1-infected adults (mean age = 31.1 years, 69% female) living in Lusaka, Zambia to assess the prevalence and associated predictors of helminth infection. We found at least one type of intestinal helminth in 24.9% of HIV-infected adults. Thirty-nine (52.7%) were infected with Ascaris lumbricoides, and 29 (39.2%) were infected with hookworm. More than 80% were light-intensity infections. A recent visit to a rural area, food shortage, and prior history of helminth infection were significant predictors of current helminth status. The high helminth prevalence and potential for adverse interactions between helminths and HIV suggests that helminth diagnosis and treatment should be part of routine HIV care.
Modjarrad
Kayvon
K
Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama, USA. abraxas@uab.edu
Zulu
Isaac
I
Redden
David T
DT
Njobvu
Lungowe
L
Freedman
David O
DO
Vermund
Sten H
SH
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000469:parasitology; D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006373:Helminthiasis / Q000150:complications / Q000453:epidemiology* / Q000469:parasitology; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000150:complications / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D015024:Zambia / Q000453:epidemiology