title: Acute transverse myelitis following dengue virus infection.
abstract: The spinal cord is infrequently affected following dengue virus infection. We report a case of transverse myelitis that developed 2 weeks after acute dengue infection and review the literature to elucidate the pathogenesis of spinal cord involvement in dengue infection. We postulate that temporal factors may play a role in the different clinical manifestations, i.e. that acute parainfectious dengue infection presents with flaccid paralysis, whereas late-stage (postinfectious) dengue infection, presents with spastic weakness. Further studies need to be performed to elucidate the mechanisms of spinal neurological damage in dengue.
authors.affiliation: Division of Neurology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. raymond_seet@nus.edu.sg
authors.forename: Raymond C S
authors.initials: RC
authors.lastname: Seet
authors.forename: Erle C H
authors.initials: EC
authors.lastname: Lim
authors.forename: Einar P V
authors.initials: EP
authors.lastname: Wilder-Smith
mesh_terms: D000328:Adult; D003715:Dengue / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D009188:Myelitis, Transverse / Q000209:etiology* / Q000503:physiopathology