title: [Comparison and improvement in the methods of establishing animals model of experimental chronic sinusitis in rabbits].
abstract: OBJECTIVE
  To compare and improve the methods of establishing animal model of experimental chronic sinusitis in rabbits .
  
  
  METHODS
  Sixty-six New Zealand white rabbits were divided into seven groups: control group, sham-operation group I, sham-operation group II, bacteria inoculation group, ostia-blocked group, ostia-blocked and bacteria inoculation group, incomplete ostium blocked and set-cotton group. The animals were examined by the methods of histology and bacteriology after 42 days.
  
  
  RESULTS
  The positive rate of chronic inflammation in ostium blocked group was 80%, inoculated staphylococcus group was 100%, incomplete ostium blocked and set-cotton group was 100%, and the other groups were 0%. All infected sinuses displayed signs of moderate or severe chronic inflammation. The cultivated bacteria were mainly opportunistic pathogens. The probability of having abscess in maxillary sinus was high in ostia-blocked and bacteria inoculation group.
  
  
  CONCLUSIONS
  The method of incomplete ostium blockage and set cotton can establish stable chronic sinusitis model, it is a simple and perfect method.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Medicine College, Shantou University, Shantou 515041, China. longzaidahai@sohu.com
authors.forename: Bin
authors.initials: B
authors.lastname: Lin
authors.forename: Hui-Ge
authors.initials: HG
authors.lastname: Wang
authors.forename: Xin-Qiang
authors.initials: XQ
authors.lastname: Lin
authors.forename: Xiao-Fen
authors.initials: XF
authors.lastname: Liu
authors.forename: Yuan-Chun
authors.initials: YC
authors.lastname: Huang
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D011817:Rabbits; D012852:Sinusitis / Q000382:microbiology