A new insertion in the HIV-1 reverse transcriptase gene inducing major resistance to non-nucleoside reverse transcriptase inhibitors.
We identified an HIV-1 isolate with a 3 base pairs insertion in the 100-105 region of the reverse transcriptase gene (RT) along with a G190E and a V75A mutation. Virus carrying the insertion alone or in association with G190A was not infectious. The association of G190E and the 100-105 insertion displayed a high level of resistance to non-nucleoside reverse transcriptase inhibitors; the addition of the insertion to G190E may increase the activity of RT.
Amiel
Corinne
C
Virology Laboratory, Hôpital Tenon, Paris, France.
Desire
Nathalie
N
Schneider
Veronique
V
Delphin
Nathalie
N
Race
Ester
E
Clavel
Françoise
F
Piolot
Tristan
T
Dam
Elisabeth
E
Rozenbaum
Willy
W
Nicolas
Jean-Claude
JC
D004251:DNA Transposable Elements / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*
D004251:DNA Transposable Elements; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase