title: Can neck size in elastase-induced aneurysms be controlled? A prospective study.
abstract: OBJECTIVE
  An earlier retrospective study indicated that the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the inflated balloon. We report the current prospective study to confirm our previous work.
  
  
  METHODS
  Ninety elastase-induced aneurysms were created in rabbits. Group 1 (n = 62) included cases in which the occlusion balloon resided low, completely within the brachiocephalic/subclavian arteries. Group 2 (n = 28) included cases in which the balloon resided high, within both the common carotid artery and brachiocephalic/subclavian arteries. Follow-up digital subtraction angiography was performed. The aneurysm sizes were measured and compared between groups. The Student t test and the Fisher exact test were used for statistical analysis.
  
  
  RESULTS
  The mean aneurysm neck diameter and width for group 1 was significantly larger than that of group 2 (3.4 +/- 1.2 and 2.3 +/- 0.9 mm, P < .001; 3.8 +/- 1.0 and 3.3 +/- 0.9 mm, P < .05, respectively). The proportion of wide-necked aneurysms in group 1 was significantly larger than that in group 2 (29% vs 4%; P < .005). Mean dome-to-neck ratios were 1.2 +/- 0.4 and 1.7 +/- 0.7 for groups 1 and 2 (P < .005). There was no significant difference in aneurysm height between groups 1 and 2 (8.0 +/- 1.7 and 7.5 +/- 2.2 mm; P > .05).
  
  
  CONCLUSIONS
  The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Ding
authors.forename: Daying
authors.initials: D
authors.lastname: Dai
authors.forename: Debra A
authors.initials: DA
authors.lastname: Lewis
authors.forename: Mark A
authors.initials: MA
authors.lastname: Danielson
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Kadirvel
authors.forename: Jayawant N
authors.initials: JN
authors.lastname: Mandrekar
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Cloft
authors.forename: David F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D021721:Balloon Occlusion; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology*; D010196:Pancreatic Elastase; D011817:Rabbits
chemical_list: D010196:Pancreatic Elastase