Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas.
OBJECTIVE
To determine whether there is an association between gene expression profile and looping extravascular matrix patterns in primary uveal melanomas.


METHODS
Laboratory investigation.


METHODS
Formalin-fixed, paraffin-embedded sections from 22 primary uveal melanomas that previously were analyzed by microarray gene expression profiling were stained for periodic acid-Schiff and scored in a masked fashion for the presence of looping extravascular matrix patterns.


RESULTS
A strong association was observed between looping patterns and the unfavorable class 2 molecular prognostic signature (P < .001).


CONCLUSIONS
Looping extravascular matrix patterns occur almost exclusively in class 2 uveal melanomas. This finding may provide new insights into the pathogenesis and management of uveal melanoma.
Onken
Michael D
MD
Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Lin
Amy Y
AY
Worley
Lori A
LA
Folberg
Robert
R
Harbour
J William
JW
D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D008545:Melanoma / Q000098:blood supply*; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis; D010503:Periodic Acid-Schiff Reaction; D014604:Uveal Neoplasms / Q000098:blood supply*
D009363:Neoplasm Proteins