title: Interleaved acquisition of lipid and water images of the heart using a double-inversion fast spin-echo method.
abstract: In this work we present a new method for the improved detection of lipid infiltration in the heart. The method employs a double-inversion fast spin-echo technique where the acquisition of water- and lipid-suppressed k-space data is alternated between TR periods to produce co-registered lipid and water images from data acquired in a breath hold. The lipid and water images can then be combined to generate a lipid/water image with reduced artifacts due to flow and excellent contrast between lipid and myocardium. The method is demonstrated in ex vivo tissue and in vivo. This novel method may improve the detection of lipid infiltration in the heart in pathologies such as arrhythmogenic right ventricular dysplasia.
authors.affiliation: Department of Radiology, University of Arizona, Tucson, Arizona 85724, USA. maltbach@u.arizona.edu
authors.forename: Maria I
authors.initials: MI
authors.lastname: Altbach
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.forename: Ali
authors.initials: A
authors.lastname: Bilgin
authors.forename: Frank I
authors.initials: FI
authors.lastname: Marcus
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Sorrell
authors.forename: Arthur F
authors.initials: AF
authors.lastname: Gmitro
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
mesh_terms: D000465:Algorithms; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000175:diagnosis* / Q000378:metabolism*; D017352:Echo-Planar Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D050356:Lipid Metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels; D014867:Water / Q000378:metabolism*
chemical_list: D013113:Spin Labels; D014867:Water