The assignment of the absolute configuration of 1,2-diols by low-temperature NMR of a single MPA derivative.
[reaction: see text] The absolute configuration of 1,2-primary/secondary diols can be easily assigned by low-temperature NMR of a bis-MPA ester derivative. The assignment requires the analysis of just the methylene protons, is not limited by the absence of signals from the R group of the diol, and requires a very small and recoverable sample.
Freire
Félix
F
Departamento de Química Orgánica, Facultad de Química, and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, Spain.
Seco
José Manuel
JM
Quiñoá
Emilio
E
Riguera
Ricardo
R
D000438:Alcohols / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D004952:Esters; D010648:Phenylacetates; C512803:alpha-methoxy-alpha-phenylacetic acid