Expression of HBsAg and HBcAg in the ovaries and ova of patients with chronic hepatitis B.
OBJECTIVE
To investigate the expression and distribution of HBV in the ovaries and ova.


METHODS
The immunohistochemistry method was used to detect the HBsAg and HBcAg in the ovaries of patients with chronic hepatitis B.


RESULTS
Expression of HBsAg in the ova, granular and interstitial cells of the ovaries was located in the cytomembrane and cytoplasm. Expression of HBcAg in the ova, granular, interstitial and endothelial cells of interstitial blood vessels of the ovaries was found in the cytomembrane, cytoplasm, and nuclei.


CONCLUSIONS
HBV can infect the ova at different stages of development and replicate in it.
Ye
Feng
F
Department of Infectious Disease, First Hospital of Xi'an Jiaotong University, Jiankang Road 1#, Xi'an 710061, Shaanxi Province, China. yefeng.jiaotong@163.com
Yue
Ya-Fei
YF
Li
Shu-Hong
SH
Chen
Tian-Yan
TY
Zhang
Shu-Ling
SL
Bai
Gui-Qin
GQ
Liu
Min
M
D005260:Female; D015967:Gene Expression Regulation, Viral; D006512:Hepatitis B Core Antigens / Q000235:genetics / Q000378:metabolism*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000378:metabolism*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D010053:Ovary / Q000166:cytology / Q000821:virology*; D010063:Ovum / Q000166:cytology / Q000821:virology*
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens