Decrease in the glyceraldehyde derived advanced glycation end products in the sera of patients with Vogt-Koyanagi-Harada disease.
OBJECTIVE
Advanced glycation end products (AGEs) are considered to act as mediators of both age related pathologies and diabetic complications. It was recently reported that glyceraldehyde derived AGE (AGE-2) has a strong biological effect on various diseases. The aim of this study was to investigate the serum AGE-2 levels in Vogt-Koyanagi-Harada (VKH) disease.


METHODS
Sera were obtained from 31 patients with active VKH. 20 of these 31 patients were treated with systemic corticosteroids. As controls, 33 healthy volunteers were also examined. The serum AGE-2 levels were determined with a competitive enzyme linked immunosorbent assay using AGE-2 polyclonal antibody.


RESULTS
The mean AGE-2 level in the sera of patients with VKH disease was 4.91 (SD 2.23) U/ml, which was significantly lower than that of the healthy control subjects (8.32 (2.94), p<0.001). The average serum AGE-2 level significantly increased to 13.49 (2.17) U/ml after the patients were treated with systemic corticosteroids (p<0.001).


CONCLUSIONS
These results suggest that AGE-2 may be involved in the onset of VKH disease.
Kitamura
M
M
Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan. mizukita825@ybb.ne.jp
Kitaichi
N
N
Takeuchi
M
M
Kitamei
H
H
Namba
K
K
Yamagishi
S-I
SI
Iwabuchi
K
K
Onoé
K
K
Ohno
S
S
D000208:Acute Disease; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D005985:Glyceraldehyde / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D014607:Uveomeningoencephalitic Syndrome / Q000097:blood* / Q000188:drug therapy
D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D005985:Glyceraldehyde