title: The addition of O2 to the CO2 does not prevent the systemic effects of the CO2 pneumoperitoneum in a rabbit model.
abstract: CO2 pneumoperitoneum used in endoscopic surgery induces systemic effects by CO2 absorption. It was claimed that a reduction in CO2 pneumoperitoneum-induced metabolic hypoxemia was achieved by the addition of small amounts of O2 to the CO2 in a rabbit ventilated model. We reevaluated the effects of the addition of O2 to the CO2 pneumoperitoneum upon CO2 absorption in a rabbit model. The effects of a pneumoperitoneum using 100% CO2, 90% CO2 + 10% O2, 95% CO2 + 5% O2, or 100% O2 on arterial blood gases, acid base and O2 homeostasis were evaluated in nonintubated rabbits. A pneumoperitoneum pressure of 10 cm H2O (approximately 7.35 mm Hg) was used. CO2 pneumoperitoneum of 120 minutes affected blood gases and acid base homeostasis. Whereas partial pressure of CO2 and HCO3 increased (P < 0.001) during pneumoperitoneum, pH and partial pressure of O2 decreased (P < 0.001). Similar results were obtained in O2-CO2 pneumoperitoneum (P > 0.05). CO2 pneumoperitoneum profoundly affected blood gases and acid base homeostasis, resulting in metabolic hypoxemia. The addition of O2 to the CO2 did not prevent the systemic effects of CO2 pneumoperitoneum in nonintubated animals.
authors.affiliation: Department of Paediatric Surgery and Research Centre of Gülhane Military Medical Academy, Ankara, Turkey. sdemirbag@gata.edu.tr
authors.forename: Suzi
authors.initials: S
authors.lastname: Demirbag
authors.forename: Narter
authors.initials: N
authors.lastname: Yesildaglar
authors.forename: Bülent
authors.initials: B
authors.lastname: Güleç
authors.forename: Osman
authors.initials: O
authors.lastname: Erogul
authors.forename: Mesut
authors.initials: M
authors.lastname: Pekcan
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage; D004724:Endoscopy / Q000379:methods*; D005260:Female; D000860:Hypoxia / Q000209:etiology; D010100:Oxygen / Q000008:administration & dosage*; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D011817:Rabbits
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen