Bacterial interference for prevention of urinary tract infection: a prospective, randomized, placebo-controlled, double-blind pilot trial.
This prospective, randomized, placebo-controlled, double-blind pilot trial examined the efficacy of bacterial interference in preventing urinary tract infection (UTI) in 27 patients with spinal cord injury. Patients whose bladders became colonized with Escherichia coli 83972 were half as likely (P=.01) than noncolonized patients to develop UTI during the subsequent year.
Darouiche
Rabih O
RO
Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas, USA. rdarouiche@aol.com
Thornby
John I
JI
Cerra-Stewart
Colleen
C
Donovan
William H
WH
Hull
Richard A
RA
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004926:Escherichia coli / Q000145:classification / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013119:Spinal Cord Injuries / Q000150:complications; D001743:Urinary Bladder / Q000382:microbiology; D014546:Urinary Catheterization / Q000009:adverse effects; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control* / Q000652:urine; D014556:Urine / Q000382:microbiology