Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitis.
A case--control study was conducted to evaluate the relationship between C481T and G590A polymorphisms of arylamine-N-acetyltransferase 2 and predisposition to atopic dermatitis in children. Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects.
Makarova
S I
SI
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Russia. makar@soramn.ru
Dodunova
E M
EM
Ivanova
G G
GG
Vavilin
V A
VA
Kaznacheeva
L F
LF
Lyakhovich
V V
VV
D000293:Adolescent; D000483:Alleles; D019943:Amino Acid Substitution; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000097:blood / Q000235:genetics; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000378:metabolism; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
D004247:DNA; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human; D005998:Glycine