Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked.
Bhatt
Apoorva
A
Department of Biochemistry, University of Cambridge, UK.
Stark
Christian B W
CB
Harvey
Barbara M
BM
Gallimore
Andrew R
AR
Demydchuk
Yuliya A
YA
Spencer
Jonathan B
JB
Staunton
James
J
Leadlay
Peter F
PF
D003500:Cyclization; D008968:Molecular Conformation; D008985:Monensin / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D011090:Polyenes / Q000737:chemistry*; D048630:Polyketide Synthases / Q000737:chemistry*; D013237:Stereoisomerism; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics
D011090:Polyenes; D048630:Polyketide Synthases; D008985:Monensin