High-density lipoprotein particles may regulate hemostasis in human pregnancy.
We explored the association of apolipoprotein A-I (the major protein constituent of high-density lipoprotein (HDL)) and fibrin fragment D-dimer (a marker of cross-linked fibrin turnover) in pregnant women. A significant inverse correlation between the levels of apolipoprotein A-I and fibrin fragment D-dimer was observed in both pre-eclamptic and normal pregnant women (rs = -0.459, n = 37 and rs = -0.290, n = 55, respectively), suggesting a major regulating role of HDL in hemostasis during pregnancy.
Belo
Luís
L
Department of Biochemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal. luis_fbelo@yahoo.com
Santos-Silva
Alice
A
Lowe
Gordon
G
Rumley
Ann
A
Quintanilha
Alexandre
A
Rebelo
Irene
I
D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D011247:Pregnancy / Q000097:blood* / Q000502:physiology*; D018709:Statistics, Nonparametric
D008075:Lipoproteins, HDL