title: Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
abstract: We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.
authors.affiliation: Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442-749, Republic of Korea.
authors.forename: Hye-Seong
authors.initials: HS
authors.lastname: Park
authors.forename: Bo Kyung
authors.initials: BK
authors.lastname: Lee
authors.forename: Sok
authors.initials: S
authors.lastname: Park
authors.forename: Seung U
authors.initials: SU
authors.lastname: Kim
authors.forename: Soo Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Eun Joo
authors.initials: EJ
authors.lastname: Baik
authors.forename: Sunkyung
authors.initials: S
authors.lastname: Lee
authors.forename: Kyu Yang
authors.initials: KY
authors.lastname: Yi
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Yoo
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Moon
authors.forename: Yi-Sook
authors.initials: YS
authors.lastname: Jung
mesh_terms: D000818:Animals; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005110:Extracellular Space / Q000187:drug effects; D018698:Glutamic Acid / Q000009:adverse effects; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D016202:N-Methylaspartate / Q000009:adverse effects; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D015424:Reperfusion / Q000379:methods; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D006146:Guanidines; D017923:Sodium-Hydrogen Exchangers; D013778:Tetrazolium Salts; D013844:Thiazoles; D018698:Glutamic Acid; D016202:N-Methylaspartate; C022616:thiazolyl blue; D002118:Calcium; C476560:sabiporide