[Suicidal ideations and suicide attempts after starting on aripiprazole, a new antipsychotic drug].
In 5 patients, 3 women aged 30, 32 and 41 years and 2 men aged 36 and 56 years, serious side effects developed after starting aripiprazole, a new antipsychotic drug. 2 patients had not been treated with antipsychotic drugs before, while in 3 there was a switch in antipsychotic treatment. The side effects consisted primarily oftroubling feelings ofagitation, akathisia, insomnia and dysphoria. 3 of the patients made a suicide attempt and 2 developed suicidal thoughts. The patients had not previously attempted suicide and the suicidal thoughts disappeared after discontinuation ofaripiprazole. Suicidal tendencies have not been reported before as a side effect ofaripiprazole.
Scholten
M R M
MR
Universitair Medisch Centrum Utrecht, Rudolf Magnus Instituut voor Neurowetenschappen, afd. Psychiatrie, Postbus 85.500, 3508 GA Utrecht. m.r.m.scholten@cs.com
Selten
J P
JP
D000328:Adult; D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000068180:Aripiprazole; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy*; D015363:Quinolones / Q000009:adverse effects* / Q000627:therapeutic use; D013406:Suicide, Attempted / Q000523:psychology; D013850:Thinking / Q000187:drug effects
D014150:Antipsychotic Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole