Free insulin-like growth factor-1 levels in bladder growth following spinal cord injury experimentally.
BACKGROUND
To determine the levels of spinal cord injury (SCI) on free insulin-like growth factor-1 (IGF-1) content in the bladder and the possible role of free IGF-1 in growth in hypertrophic bladders in an experimental model.


METHODS
The contents of free IGF-1 and protein in paraplegic and non-paraplegic rats which was induced experimentally by SCI were measured. The wet weights of the bladders were also determined. The results gained were compared.


RESULTS
The mean bladder free IGF-1 level in paraplegic rats was significantly higher than the corresponding bladder free IGF-1 level in sham-operated bladder (p<0.05). Mean wet weight bladder in paraplegic rats was significantly higher than the sham-operated rats (p<0.05). Paraplegic bladder had a significantly higher mean protein content than the sham-operated bladder (p<0.05). Serum free IGF-1 levels in the two groups were not different.


CONCLUSIONS
Our pilot study reveals that free IGF-1 may be effective in SCI.
Serel
T Ahmet
TA
Department of Urology, Suleyman Demirel University, School of Medicine, Isparta, and Ankara Numune Hospital, Turkey. aserel@med.sdu.edu.tr
Uysal
Eda
E
Kutluhan
Süleyman
S
Soyupek
Sedat
S
Kiliç
Sahir
S
Hoşcan
M Burak
MB
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D006984:Hypertrophy / Q000378:metabolism / Q000473:pathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000150:complications / Q000378:metabolism*; D001743:Urinary Bladder / Q000254:growth & development* / Q000294:innervation / Q000378:metabolism*; D001745:Urinary Bladder Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology
D015415:Biomarkers; D007334:Insulin-Like Growth Factor I