Tissue and intracellular reorganization of rat liver during total body hypothermia.
We studied tissue and intracellular reorganization of the liver during total body hypothermia and evaluated regeneration strategies at different levels of structural organization. Hypothermia results in morphofunctional changes in the liver (degeneration, lysis, necrobiosis, and focal necrosis of hepatocytes developing against the background of disorders in blood and lymph circulation). Decreased sinusoid/hepatocyte volume ratio is the key factor in tissue reorganization of the liver. Intracellular reorganization of hepatocytes is characterized by dysproportional changes in the volume and surface densities of the main cytoplasmic organelles involved in biosynthesis and energy production.
Molodykh
O P
OP
Department of Cellular Biology and Morphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Klinnikova
M G
MG
Lushnikova
E L
EL
Nepomnyashchikh
L M
LM
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology / Q000648:ultrastructure; D018870:Endoplasmic Reticulum, Rough / Q000473:pathology / Q000648:ultrastructure; D018871:Endoplasmic Reticulum, Smooth / Q000473:pathology / Q000648:ultrastructure; D006003:Glycogen / Q000378:metabolism / Q000648:ultrastructure; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D007036:Hypothermia, Induced; D008099:Liver / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D008247:Lysosomes / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008930:Mitochondria, Liver / Q000473:pathology / Q000648:ultrastructure; D009336:Necrosis / Q000473:pathology; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D006003:Glycogen