title: Carcinoma ex benign pleomorphic adenoma of the parotid gland.
abstract: BACKGROUND
  Carcinoma in pleomorphic salivary adenoma is a common histologic subtype of primary parotid malignancy.
  
  
  METHODS
  In this study, 28 patients (predominantly male) with histologically diagnosed carcinoma in pleomorphic salivary adenoma presenting over 10 years were retrospectively reviewed.
  
  
  RESULTS
  Only 25 percent of patients had a previously treated pleomorphic salivary adenoma. Although the presenting features suggested malignancy in some cases, overall they were nonspecific, overlapping with the presentation of benign disease. Preoperative investigations included fine needle aspiration cytology, which was only 29-percent sensitive, and computed tomography and/or magnetic resonance imaging. There were 14 superficial and 12 total or radical parotidectomies. The facial nerve was resected en bloc with the tumor in nine cases and immediately reconstructed with good reanimation results in patients with recent-onset facial paresis. Only 44 percent of patients had a complete histologic tumor clearance, and this was the most significant determinant of survival (p < 0.01, log-rank analysis). The locoregional control rate was 66 percent at 5 years, but recurrent disease proved invariably fatal. Five-year disease-specific survival was 44 percent with a high rate of disease-specific mortality (87 percent).
  
  
  CONCLUSIONS
  Carcinoma in pleomorphic salivary adenoma is very difficult to diagnose preoperatively. Fine needle aspiration cytology had a disappointingly low sensitivity for this tumor, potentially misdirecting surgical management. While good locoregional disease control could be achieved with surgery and radiotherapy, carcinoma in pleomorphic salivary adenoma was shown to be aggressive with a high disease-specific rate of mortality. Given that incomplete tumor resection was the most important prognostic factor, a high index of clinical suspicion, radical ablative surgery, and immediate soft-tissue and nerve reconstruction for proven cases are advocated.
authors.affiliation: Hammersmith Hospital, London, United Kingdom. rn@cantab.net
authors.forename: S A Reza
authors.initials: SA
authors.lastname: Nouraei
authors.forename: Kirsten L
authors.initials: KL
authors.lastname: Hope
authors.forename: Charles G
authors.initials: CG
authors.lastname: Kelly
authors.forename: Neil R
authors.initials: NR
authors.lastname: McLean
authors.forename: James V
authors.initials: JV
authors.lastname: Soames
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D019583:Dose Fractionation, Radiation; D004739:England / Q000453:epidemiology; D005154:Facial Nerve / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D016019:Survival Analysis