title: Effect of SNC19/ST14 gene overexpression on invasion of colorectal cancer cells.
abstract: OBJECTIVE
  To study the effect of SNC19/ST14 gene overexpression on invasion in vitro of colorectal cancer cells.
  
  
  METHODS
  The adhesion of SNC19/ST14 gene-transfected cells to ECM was measured by MTT assay. The cell movement was evaluated by wound healing assay. Cell invasion and migration were determined by invasion assay in vitro.
  
  
  RESULTS
  SNC19/ST14 gene overexpression could enhance invasion of colorectal cancer cells in vitro significantly and influence early cell adherence to ECM, but could not change cell movement significantly.
  
  
  CONCLUSIONS
  SNC19/ST14 gene overexpression increases the local invasion of colorectal cancer cells in vitro.
authors.affiliation: Surgery of Oncology, The Second Affiliated Hospital, School of Medicine, Zhejinag University, Hangzhou 310009, Zhejiang Province, China.
authors.forename: Ke-Feng
authors.initials: KF
authors.lastname: Ding
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Sun
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Ge
authors.forename: Han-Guang
authors.initials: HG
authors.lastname: Hu
authors.forename: Su-Zhan
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
mesh_terms: D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002465:Cell Movement; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness; D012697:Serine Endopeptidases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012697:Serine Endopeptidases; C485596:ST14 protein, human