title: Evaluation of the effect of methadone maintenance treatment program on the frequency of DNA lesions revealed as micronuclei and sister chromatid exchanges.
abstract: The aim of the present paper was to examine the effect of substitution methadone treatment on the frequency of DNA lesions using a micronuclear and a sister chromatid exchange tests. The material under study were lymphocyte cultures from peripheral blood, collected 3 times at 3-month intervals from 24 patients. The obtained results may suggest that methadone treatment combined with a change in lifestyle significantly reduces the risk of genome lesions.
authors.affiliation: Department of Anthropology, Institute of Zoology, Jagiellonian University, Kraków, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Furtak
authors.forename: Dorota
authors.initials: D
authors.lastname: Pach
authors.forename: Jan
authors.initials: J
authors.lastname: Chrostek Maj
authors.forename: Jan
authors.initials: J
authors.lastname: Schmager
mesh_terms: D000328:Adult; D004249:DNA Damage / Q000187:drug effects*; D005260:Female; D005819:Genetic Markers / Q000187:drug effects; D006801:Humans; D008019:Life Style; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008691:Methadone / Q000494:pharmacology*; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced / Q000187:drug effects*; D008875:Middle Aged; D009294:Narcotics / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000235:genetics*; D011044:Poland; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors
chemical_list: D005819:Genetic Markers; D009294:Narcotics; D008691:Methadone