N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase.
Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors.
Gavalda
Sabine
S
Laboratoire de Synthèse et de Physico-Chimie de Molécules d'intérêt Biologique, Groupe de Chimie Organique Biologique, UMR 5068, Université Paul Sabatier, Bât IIR1, 118 route de Narbonne, 31062 Toulouse Cedex 4, France.
Braga
Rémi
R
Dax
Chantal
C
Vigroux
Alain
A
Blonski
Casimir
C
D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors*; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D007700:Kinetics; D008322:Mammals; D063065:Organophosphonates / Q000138:chemical synthesis / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D063065:Organophosphonates; D005634:Fructose-Bisphosphate Aldolase