The influence of cigarette smoke inhalation on bone density. A radiographic study in rats.
The aim of this study was to evaluate the influence of cigarette smoke inhalation (CSI) and its cessation on tibiae bone quality. Forty-one male Wistar rats were randomly assigned to one of the following groups: Group 1--control (n = 14), Group 2--3 months of CSI and 2 months without exposure to CSI (n = 12), and Group 3--5 months of CSI (n = 15). At the end of the experimental period, the animals were sacrificed, the tibiae removed and immediately radiographed for photodensitometric analysis. The results showed that continuous exposure to cigarette smoke promoted a significantly reduced bone density (p < 0.05) (3.22 mm Al eq +/- 0.58; 2.93 mm Al eq +/- 0.45; 1.86 mm Al eq +/- 0.35; for groups 1, 2 and 3, respectively). Similar levels of bone density were observed for the control and cessation groups (groups 1 and 2 - p > 0.05). Thus, within the limits of the present study, it can be concluded that CSI may affect tibiae bone quality, and CSI cessation results in a return towards the level of the control group.
César-Neto
João Batista
JB
Division of Periodontics, School of Dentistry of Piracicaba, State University of Campinas.
Benatti
Bruno Braga
BB
Manzi
Flávio Ricardo
FR
Sallum
Enilson Antônio
EA
Sallum
Antônio Wilson
AW
Nociti
Francisco Humberto Junior
FH
D015502:Absorptiometry, Photon; D000818:Animals; D015519:Bone Density; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000000981:diagnostic imaging* / Q000502:physiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D014028:Tobacco Smoke Pollution