title: Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, K-15-3/3545, Kenilworth, NJ 07033, USA. kevin.chen@spcorp.com
authors.forename: Kevin X
authors.initials: KX
authors.lastname: Chen
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
authors.forename: Bancha
authors.initials: B
authors.lastname: Vibulbhan
authors.forename: Andrew
authors.initials: A
authors.lastname: Prongay
authors.forename: John
authors.initials: J
authors.lastname: Pichardo
authors.forename: Vincent
authors.initials: V
authors.lastname: Madison
authors.forename: Alexei
authors.initials: A
authors.lastname: Buevich
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
mesh_terms: D018360:Crystallography, X-Ray; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D011392:Proline / Q000737:chemistry*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D047028:Macrocyclic Compounds; D015842:Serine Proteinase Inhibitors; D011392:Proline; D019272:Leukocyte Elastase