Comparative assessment of conduction anesthesia produced by procaine, marcaine, richlocaine, and RU-353.
Conduction anesthesia of the vagus nerve produced by procaine (0.5%), marcaine (0.25%), richlocaine (0.5%), and imidazobenzoimidazole derivative RU-353 (0.25%) was compared in acute experiments on cats. RU-353 produced the most long-term local anesthesia (assessed by inhibition of cardiochronotropic effect of vagus nerve).
Galenko-Yaroshevskii
A P
AP
Krasnodar Regional Research Medical Center, Moscow.
Sheikh-Zade
Yu P
YP
Cherednik
I L
IL
D000765:Anesthesia, Conduction; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology*; D002415:Cats; D004353:Drug Evaluation, Preclinical; D010880:Piperidines / Q000494:pharmacology*; D011343:Procaine / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects
D000779:Anesthetics, Local; D001562:Benzimidazoles; D010880:Piperidines; C507880:RU 353; C493511:richlocaine; D011343:Procaine; D002045:Bupivacaine