title: [Spinal anaesthesia for Caesarean section: dose injection speed have an effect on the incidence of hypotension?].
abstract: OBJECTIVE
  To study effect of injection rate on spinal blockade and haemodynamic of spinal bupivacaine for Caesarean section.
  
  
  METHODS
  Prospective and randomized.
  
  
  METHODS
  Sixty ASA I-II patients scheduled for elective Caesarean section were randomized to receive either fast (20 seconds, group R, n=30) or slow (60 seconds, group L, n=30) spinal injection of 10 mg of hyperbaric bupivacaine 0.5% associated with 25 microg of fentanyl and 100 microg of morphine. Sensory and motor blockade and haemodynamic parameters were recorded.
  
  
  RESULTS
  Profiles of sensory and motor block were similar in both groups. Variations of arterial blood pressure and total dose of ephedrine were not different between R and L groups. However, the number of patient with systolic blood pressure lower than 100 mmHg were significantly lower in L group than in R group (p=0.04). Incidences of adverse effects were similar in both groups.
  
  
  CONCLUSIONS
  Result of the present study suggests that a slow rate of injection would induce lower incidence of hypotension induced by spinal bupivacaine for Caesarean section.
authors.affiliation: Service d'anesthésie-réanimation, centre de maternité et de néonatologie de Tunis, rue Jabel-Lakhdar, 1007 La Rabta, Tunis, Tunisie. mouradbouchnak@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Bouchnak
authors.forename: N
authors.initials: N
authors.lastname: Belhadj
authors.forename: T
authors.initials: T
authors.lastname: Chaaoua
authors.forename: W
authors.initials: W
authors.lastname: Azaiez
authors.forename: M
authors.initials: M
authors.lastname: Hamdi
authors.forename: H
authors.initials: H
authors.lastname: Maghrebi
mesh_terms: D000759:Adjuvants, Anesthesia; D000328:Adult; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine; D002585:Cesarean Section; D004311:Double-Blind Method; D004809:Ephedrine / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005283:Fentanyl; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000453:epidemiology*; D009020:Morphine; D009046:Motor Neurons / Q000187:drug effects; D009407:Nerve Block; D009475:Neurons, Afferent / Q000187:drug effects; D011247:Pregnancy; D011446:Prospective Studies; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000759:Adjuvants, Anesthesia; D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D009020:Morphine; D004809:Ephedrine; D005283:Fentanyl; D002045:Bupivacaine