Antigen-specific down-regulation of immunopathological events in an experimental autoimmune kidney disease.
Heymann nephritis (HN) is an experimental autoimmune disease of rats characterized by immune-complex (IC) depositions on the epithelial side of the glomerular basement membrane (GBM) and by proteinuria. Several forms of HN have been produced by various investigators, but one thing has been common to all of them, namely their inducement by the development of pathogenic IgG autoantibodies (aabs). The aim of this review is to describe how pathogenic IgG aab production (which initiates and maintains the disease) in slowly progressive HN (SPHN) can be specifically terminated by injections of ICs made up of native rat renal tubular antigens and IgM antibodies directed against them.
Barabas
Arpad Zsigmond
AZ
Department of Surgery, University of Calgary Health Sciences Centre, 2802 Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4N1. barabas@ucalgary.ca
Lafreniere
Rene
R
D000818:Animals; D000936:Antigen-Antibody Complex / Q000096:biosynthesis; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology*; D001324:Autoantigens / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D001485:Basement Membrane / Q000378:metabolism; D015536:Down-Regulation / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology*
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001324:Autoantigens