Keynote review: The auditory system, hearing loss and potential targets for drug development.
There is a huge potential market for the treatment of hearing loss. Drugs are already available to ameliorate predictable, damaging effects of excessive noise and ototoxic drugs. The biggest challenge now is to develop drug-based treatments for regeneration of sensory cells following noise-induced and age-related hearing loss. This requires careful consideration of the physiological mechanisms of hearing loss and identification of key cellular and molecular targets. There are many molecular cues for the discovery of suitable drug targets and a full range of experimental resources are available for initial screening through to functional analysis in vivo. There is now an unparalleled opportunity for translational research.
Holley
Matthew C
MC
Department of Biomedical Sciences, Addison Building, Western Bank, Sheffield S10 2TN, UK. m.c.holley@sheffield.ac.uk
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D003051:Cochlea / Q000033:anatomy & histology; D015195:Drug Design; D007758:Ear, Inner / Q000033:anatomy & histology / Q000196:embryology / Q000502:physiology; D006198:Hair Cells, Auditory / Q000166:cytology / Q000502:physiology; D034381:Hearing Loss / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D012038:Regeneration; D033581:Stem Cell Transplantation