Hypolipidaemic efficacy of Capparis decidua fruit and shoot extracts in cholesterol fed rabbits.
High fat diet caused significant (8-fold) increase in serum total cholesterol in rabbits. Administration of C. decidua fruit extract (50% ethanolic) at the dose of 500 mg/kg body weight significantly reduced serum total cholesterol (61%), LDL cholesterol (71%), triglycerides (32%) and phospholipids (25%). Similarly C. decidua shoot extract lowered serum total cholesterol (48%), LDL cholesterol (57%), triglycerides (38%) and phospholipids (36%). The cholesterol content of aorta was decreased by 44 and 28% in fruit and shoot extract treatment respectively. The HDL to total cholesterol ratio and atherogenic index was significantly decreased in plant extract treated groups suggesting antiatherosclerotic nature of these plant extract. These results reveal the hypolipidaemic potential of C. decidua fruit and shoot.
Purohit
Ashok
A
Department of Zoology, JNV University, Jodhpur 342 001, India. purohit1411@yahoo.com
Vyas
Keshav Bihari
KB
D000818:Animals; D001011:Aorta / Q000378:metabolism; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism; D001835:Body Weight; D031484:Capparis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D000431:Ethanol; D005638:Fruit; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008297:Male; D009929:Organ Size; D010743:Phospholipids / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D011817:Rabbits; D014280:Triglycerides / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010743:Phospholipids; D010936:Plant Extracts; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol