title: Asterosaponins from the starfish Culcita novaeguineae and their bioactivities.
abstract: Bioassay-guided fractionation of the n-BuOH extract of the starfish Culcita novaeguineae resulted in the isolation of one new sulfated steroidal glycoside (asterosaponin) (1), along with three known asterosaponins, thornasteroside A (2), marthasteroside A(1) (3) and regularoside A (4), as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. Their structures were elucidated by extensive spectral studies and chemical evidences. All the saponins showed moderate cytotoxicity against cancer cell lines K-562 and BEL-7402.
authors.affiliation: Research Center for Marine Drugs, College of Pharmacy, 2nd Military Medical University, Shanghai 200433, PR China. tanghaifeng71@126.com
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: San-Qi
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000187:drug effects; D001681:Biological Assay; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000633:toxicity; D013215:Starfish / Q000737:chemistry*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018675:Toxicity Tests / Q000379:methods
chemical_list: D012503:Saponins; D013261:Sterols; C513248:mathasteroside A1; C513250:regularoside A; C513249:thornasteroside A; C008330:marthasterone