title: [Current concepts of the physiopathology of coronary beta-adrenergic receptors, and their clinical applications].
abstract: Beta-adrenergic vasodilation plays a key role in the regulation of coronary blood flow, in particular during sympathetic nervous system activation. Beta1-adrenergic receptors are mostly represented in epicardial coronary vessel, while beta2 receptors are located in microvasculature. Coronary atherosclerosis is associated with a significant impairment of beta-adrenergic receptor response. This might contribute to precipitate myocardial ischemia.
authors.affiliation: Cattedra di Cardiologia, Università Federico II, Napoli. barba22@hotmail.com
authors.forename: Emanuele
authors.initials: E
authors.lastname: Barbato
authors.forename: William
authors.initials: W
authors.lastname: Wijns
authors.forename: Bernard
authors.initials: B
authors.lastname: De Bruyne
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mascia
authors.forename: Federico
authors.initials: F
authors.lastname: Piscione
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000378:metabolism*; D003326:Coronary Circulation; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D018342:Receptors, Adrenergic, beta-1 / Q000378:metabolism; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism
chemical_list: D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2