Radical medicine: treating ageing to cure disease.
The incidence of many diseases rises sharply with age. Although clearly separable, ageing and certain age-related diseases might share common mechanisms. Cellular metabolism and subsequent generation of reactive oxygen species might contribute both to the rate at which we age and to our susceptibility to numerous chronic diseases, therefore therapies that directly target the ageing process might provide new ways to treat human diseases.
Finkel
Toren
T
Cardiovascular Branch ofthe National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA. finkelt@nih.gov
D000375:Aging / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism*; D013812:Therapeutics / Q000639:trends*
D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase