title: Computer-aided detection system for breast masses on digital tomosynthesis mammograms: preliminary experience.
abstract: The purpose of the study was to design a computer-aided detection (CAD) system for breast mass detection on digital breast tomosynthesis (DBT) mammograms and to perform a preliminary evaluation of the performance of this system. Twenty-six patients were imaged with a prototype DBT system. Institutional review board approval and written informed patient consent were obtained. Use of the data set in this study was HIPAA compliant. The CAD system first screened the three-dimensional volume of the mass candidates by means of gradient-field analysis. Each mass candidate was segmented from the structured background, and its image features were extracted. A feature classifier was designed to differentiate true masses from normal tissues. The CAD system was trained and tested by using a leave-one-case-out method. The classifier calculated a mean area under the test receiver operating characteristic curve of 0.91 +/- 0.03 (standard error of mean). The CAD system achieved a sensitivity of 85%, with 2.2 false-positive objects per case. The results demonstrate the feasibility of the authors' approach to the development of a CAD system for DBT mammography.
authors.affiliation: Department of Radiology, University of Michigan, 1500 E Medical Center Dr, UHB1F510B, Ann Arbor, MI 48109-0030, USA. chanhp@umich.edu
authors.forename: Heang-Ping
authors.initials: HP
authors.lastname: Chan
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Berkman
authors.initials: B
authors.lastname: Sahiner
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rafferty
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Marilyn A
authors.initials: MA
authors.lastname: Roubidoux
authors.forename: Richard H
authors.initials: RH
authors.lastname: Moore
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Kopans
authors.forename: Lubomir M
authors.initials: LM
authors.lastname: Hadjiiski
authors.forename: Mark A
authors.initials: MA
authors.lastname: Helvie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000000981:diagnostic imaging*; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation*; D016002:Discriminant Analysis; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008327:Mammography; D008875:Middle Aged; D012372:ROC Curve