A fine-scale map of recombination rates and hotspots across the human genome.
Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.
Myers
Simon
S
Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
Bottolo
Leonardo
L
Freeman
Colin
C
McVean
Gil
G
Donnelly
Peter
P
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D019143:Evolution, Molecular; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic / Q000235:genetics*