title: Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae.
abstract: The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated. Bioassay-guided fractionation of the crude extract, monitored by larvicidal assay, led to the isolation of a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol). This compound was quite potent against A. aegypti larvae (LC50 26.3 microg/ml).
authors.affiliation: Laboratório de Farmacognosia, Faculdade de Ciências da Saúde, Universidade de Brasília, Brasília, Brazil.
authors.forename: A M S
authors.initials: AM
authors.lastname: Rodrigues
authors.forename: J E
authors.initials: JE
authors.lastname: de Paula
authors.forename: F
authors.initials: F
authors.lastname: Roblot
authors.forename: A
authors.initials: A
authors.lastname: Fournet
authors.forename: L S
authors.initials: LS
authors.lastname: Espíndola
mesh_terms: D000330:Aedes; D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry
chemical_list: D007306:Insecticides; D009285:Naphthoquinones; C008252:lapachol