Organogenesis of the endocrine pancreas.
Organogenesis of the endocrine pancreas. Embryonic pancreatic primordia transplanted into diabetic animal hosts undergo selective endocrine differentiation in situ and normalize glucose tolerance. Pancreatic primordia can be transplanted across isogeneic, allogeneic, and both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. This review explores the therapeutic potential for pancreatic organogenesis posttransplantation of embryonic primordia.
Hammerman
Marc R
MR
Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. mhammerm@wustl.edu
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D016332:Fetal Tissue Transplantation; D006801:Humans; D007515:Islets of Langerhans / Q000196:embryology*; D016035:Pancreas Transplantation; D014183:Transplantation, Heterologous