title: Type III secretion: the bacteria-eukaryotic cell express.
abstract: Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future.
authors.affiliation: Biozentrum der Universität Basel, Biozentrum, Klingelbergstrasse, 50-70 CH4051 Basel, Switzerland.
authors.forename: Luís Jaime
authors.initials: LJ
authors.lastname: Mota
authors.forename: Isabel
authors.initials: I
authors.lastname: Sorg
authors.forename: Guy R
authors.initials: GR
authors.lastname: Cornelis
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D006090:Gram-Negative Bacteria / Q000378:metabolism / Q000472:pathogenicity*; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D021381:Protein Transport; D014774:Virulence
chemical_list: D001426:Bacterial Proteins