title: Synchronous intracortical adamantinomas with keratin cyst formation.
abstract: Adamantinoma of the long bones is a rare primary bone tumor of uncertain embryogenesis. It tends to involve the tibia almost exclusively. We report on adamantinomas occurring in a 16-year-old male patient, with synchronous tibial and fibular lesions. Histologically, there were characteristic clusters of epithelial cells in a fibrous background, forming a keratin cyst. Immunohistochemically, these cells were strongly positive for cytokeratin. This keratin cyst formation is quite an unusual finding in classic adamantinoma.
authors.affiliation: Department of Pathology, College of Medicine, Kyung Hee University Hospital, 1 Hoeki-dong, Dongdaemoon-gu, Seoul, South Korea. ykpark@khmc.or.kr
authors.forename: Yong-Koo
authors.initials: YK
authors.lastname: Park
authors.forename: Kyung Nam
authors.initials: KN
authors.lastname: Ryu
authors.forename: Chung Soo
authors.initials: CS
authors.lastname: Han
mesh_terms: D050398:Adamantinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D001845:Bone Cysts / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005360:Fibula / Q000473:pathology*; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary; D013977:Tibia / Q000473:pathology*
chemical_list: D007633:Keratins