Transposable elements--is there a link between evolution and cancer?
Currently, the most predominant theory concerning the formation of cancer is that it is a genetic accident. Accordingly, various agents are thought to cause DNA damage which then subsequently activates oncogenes and inactivates tumor suppressor genes. This article, however, describes a theory that interprets cancer as a misguided adaptation. Stressors, which cannot be compensated for with the usual cell possibilities might arouse evolutionary mechanisms intended to create new protein variants. One of these is the activation of transposable elements which leads to a reformatting of the genome. The result of this process is either a cell that survives very well under stress (and will, therefore, never be detected), a dead cell (in case the process is ineffective), or a more or less abnormal and harmful cell that builds up a new but cancerous organ. This theory explains the complex genetic alterations which are present in almost all cancer cells. It also explains the action of non-mutagenic carcinogens. As part of the reformatting process of the cancer cell genome, activation of oncogenes and inactivation of tumor suppressor genes are not stochastic events but the result of an unlucky genomic composition.
Hauptmann
Steffen
S
Institute of Pathology, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse 14, D-06097 Halle (Saale), Germany. steffen.hauptmann@medizin.uni-halle.de
Schmitt
Wolfgang D
WD
D002273:Carcinogens; D004249:DNA Damage; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D016678:Genome; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D008962:Models, Theoretical; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology
D002273:Carcinogens; D004251:DNA Transposable Elements