title: Dual cryogenic fixation for mechanical testing of soft musculoskeletal tissues.
abstract: Mechanical testing of soft musculoskeletal structures like tendons and ligaments are essential to medical advances. A long-standing limitation for testing these structures in isolation has been the ability to solidly fix both ends of the tendon. Cryogenic fixation technology was leveraged into the development of a dual cryogenic fixation (DCF) device. Results of the study show that the DCF allows tendons to be tested in isolation, at physiologic temperatures, with excellent reproducibility.
authors.affiliation: Bone and Joint Research Laboratory, University of Ottawa, 451 Smyth Road, Rm. 1321, Ottawa, ON K1H 8M5 Canada. nanthanr@uottawa.ca
authors.forename: Nanthan
authors.initials: N
authors.lastname: Ramachandran
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Koike
authors.forename: Philippe
authors.initials: P
authors.lastname: Poitras
authors.forename: David
authors.initials: D
authors.lastname: Backman
authors.forename: Hans K
authors.initials: HK
authors.lastname: Uhthoff
authors.forename: Guy
authors.initials: G
authors.lastname: Trudel
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000295:instrumentation* / Q000379:methods; D015925:Cryopreservation / Q000295:instrumentation* / Q000379:methods; D004548:Elasticity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008022:Ligaments / Q000502:physiology*; D009132:Muscles / Q000502:physiology*; D010812:Physical Stimulation / Q000295:instrumentation* / Q000379:methods; D011817:Rabbits; D013314:Stress, Mechanical; D013710:Tendons / Q000502:physiology*; D016707:Tissue Fixation / Q000295:instrumentation* / Q000379:methods