title: An approach to heterobifunctional poly(ethyleneglycol) bioconjugates.
abstract: A family of differentially substituted poly(ethyleneglycol) building blocks has been assembled from commercially available material. Their utility is demonstrated by formation of amino acid conjugates, image contrast agents, gold nanoparticles, and functional antibody conjugates. Application in the cellular trafficking of antitumoral agent conjugates is expected.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Jane
authors.initials: J
authors.lastname: Li
authors.forename: Curtis F
authors.initials: CF
authors.lastname: Crasto
authors.forename: James S
authors.initials: JS
authors.lastname: Weinberg
authors.forename: Mansoor
authors.initials: M
authors.lastname: Amiji
authors.forename: Dinesh
authors.initials: D
authors.lastname: Shenoy
authors.forename: Srinivas
authors.initials: S
authors.lastname: Sridhar
authors.forename: Glenn J
authors.initials: GJ
authors.lastname: Bubley
authors.forename: Graham B
authors.initials: GB
authors.lastname: Jones
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000906:Antibodies / Q000737:chemistry; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D001665:Binding Sites; D001692:Biological Transport; D006041:Goats; D007074:Immunoglobulin G; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D000596:Amino Acids; D000906:Antibodies; D000970:Antineoplastic Agents; D007074:Immunoglobulin G; D011092:Polyethylene Glycols