title: [Do prothrombin time, transaminases, and platelet count predict the severity of fibrosis in viral liver diseases?].
abstract: The goal of our study is to assess the performance of a score combining 3 serological parameters (PT, platelets and transminases) in predictive hepatic fibrosis. The study involved 54 patients, 29 of which resulted in distributing them according to the score of Metavir into 2 groupes: Group A with mild fibrosis (F1,F2) and group B with severe fibrosis (F3,F4). PT, platelets and transminase values in serum were assessed for all patients. The total score of the 3 biological parameters combined, was significantly more elabled in the severe fibrosis group than in the mild fibrosis group (P = 0.01) but it was not of much importance in 30% of cases as it did not allow to classify the patients with certainty in group A or in group B. This score does not seem to grant exemption from needle liver biopsy, but it can be improved by the association of other direct markers of fibrosis.
authors.affiliation: Service de Gastroentérologie, Hôpital Mohamed Tahar Maamouri de Naheul.
authors.forename: Mossaddok Azzouz
authors.initials: MA
authors.lastname: Mohamed
authors.forename: Essid
authors.initials: E
authors.lastname: Majda
authors.forename: Ktari
authors.initials: K
authors.lastname: Mohamed
authors.forename: Zouari
authors.initials: Z
authors.lastname: Bechir
authors.forename: Kallel
authors.initials: K
authors.lastname: Sana
authors.forename: Ben Brahim
authors.initials: BB
authors.lastname: Ehsène
authors.forename: Chatti
authors.initials: C
authors.lastname: Samia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000821:virology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011517:Prothrombin Time; D012720:Severity of Illness Index; D000637:Transaminases / Q000097:blood*
chemical_list: D015415:Biomarkers; D000637:Transaminases