title: Chronic allograft dysfunction: diagnosis and management. Is it always progressive?
abstract: 1. There are many causes of graft dysfunction post-liver transplant, but recurrent disease remains the most common cause. 2. Viral hepatitis, nonalcoholic and alcoholic steatohepatitis, and autoimmune diseases are the most common causes of recurrent disease. 3. Graft hepatitis occurs frequently and in many cases will not progress. 4. Cirrhosis in the absence of any identifiable cause develops in a minority. 5. Treatment is of the underlying cause but some, such as recurrent and de novo autoimmune hepatitis and recurrent primary sclerosing cholangitis may not respond well, and regraft may be required.
authors.affiliation: Liver Unit, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK. J.M.Neuberger@bham.ac.uk
authors.forename: James
authors.initials: J
authors.lastname: Neuberger
mesh_terms: D001707:Biopsy, Needle; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D012008:Recurrence; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler