Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein.
Kaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus (KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain of human immunoglobulin G1 to create vOX2:Fc, suppressed neutrophil oxidative burst and inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte chemoattractant protein 1) by monocyte/macrophage cells. vOX2:Fc suppressed the acute inflammatory response in mice in which neutrophil-mediated inflammation was induced by carrageenan. The data suggest that vOX2 can contribute to immune dysfunction and could have anti-inflammatory therapeutic potential.
Rezaee
S A Rahim
SA
Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, UK.
Gracie
J Alastair
JA
McInnes
Iain B
IB
Blackbourn
David J
DJ
D000818:Animals; D015536:Down-Regulation; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000378:metabolism / Q000821:virology*; D016897:Respiratory Burst; D012514:Sarcoma, Kaposi / Q000276:immunology*; D014764:Viral Proteins / Q000502:physiology*
D014764:Viral Proteins; C510890:vOX2 protein, Kaposi's sarcoma-associated herpesvirus