title: [Level and heritability analysis of serum apoA I and apoB100 in twins].
abstract: OBJECTIVE
  To describe the serum level of apoA I and apoB100 in twins, and study the contribution of genetic and environmental effects to them.
  
  
  METHODS
  The researchers used immunoturbidimetric assay (ITA) for quantification of the serum apoA I and apoB100 in 329 monozygotic (MZ) and 173 dizygotic (DZ) twins identified by genotyping. Mx was used to fit a variety of genetic models covering age and sex for the variation of apoA I and apoB100.
  
  
  RESULTS
  The serum levels were (1.33+/-0.23) g/L for apoA I and (0.75+/-0.19) g/L for apoB100. Model AES fitted apoA I data best and scalar effects sex-limitation model AE fitted apoB100 best. 60% of the variance in apoA I was due to additive effects and 69% in apoB100.
  
  
  CONCLUSIONS
  The heritability of apoA I and apoB100 in this twin study was 60% and 69%.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China.
authors.forename: Wen-jing
authors.initials: WJ
authors.lastname: Gao
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Li
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Cao
authors.forename: Jun
authors.initials: J
authors.lastname: Lv
authors.forename: Ying
authors.initials: Y
authors.lastname: Qin
authors.forename: Wei-jian
authors.initials: WJ
authors.lastname: Chen
authors.forename: Rong-Fu
authors.initials: RF
authors.lastname: Chen
authors.forename: Yong-hua
authors.initials: YH
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood* / Q000235:genetics*; D053299:Apolipoprotein B-100 / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics
chemical_list: D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100