title: Scaffolds for microtubule inhibition through extensive modification of the epothilone template.
authors.affiliation: ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Hönggerberg, HCI H 405, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Cachoux
authors.forename: Thomas
authors.initials: T
authors.lastname: Isarno
authors.forename: Markus
authors.initials: M
authors.lastname: Wartmann
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Altmann
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D034261:Epothilones; D014404:Tubulin