Regulation of microbial immunity: the suppressor cell renaissance.
Regulatory/suppressor cells have become rehabilitated and respectable. They returned as regulators of autoimmunity, but are now acknowledged to critically influence immunity to foreign antigens, such as those found on microbes. This review describes the principal types of regulatory cells that influence immunity to microbes, focusing on viruses. We discuss both the merits and downside of the Treg response during infection. The mechanisms by which Treg are induced, recognize microbes, and exert their function is also discussed. Finally, we examine approaches that might prove useful to manipulate regulatory cell response against infections.
Suvas
Susmit
S
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0854, USA.
Rouse
Barry T
BT
D000818:Animals; D000956:Antigens, Viral; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000821:virology*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology*
D000956:Antigens, Viral; D016212:Transforming Growth Factor beta