title: 3T phased array MRI improves the presurgical evaluation in focal epilepsies: a prospective study.
abstract: BACKGROUND
  Although detection of concordant lesions on MRI significantly improves postsurgical outcomes in focal epilepsy (FE), many conventional MR studies remain negative. The authors evaluated the role of phased array surface coil studies performed at 3 Tesla (3T PA MRI).
  
  
  METHODS
  Forty patients with medically intractable focal epilepsies were prospectively imaged with 3T PA-MRI including high matrix TSE T2, fluid attenuated inversion recovery, and magnetization prepared rapid gradient echo. All patients were considered candidates for epilepsy surgery. 3T PA-MRIs were reviewed by a neuroradiologist experienced in epilepsy imaging with access to clinical information. Findings were compared to reports of prior standard 1.5T MRI epilepsy studies performed at tertiary care centers.
  
  
  RESULTS
  Experienced, unblinded review of 3T PA-MRI studies yielded additional diagnostic information in 48% (19/40) compared to routine clinical reads at 1.5T. In 37.5% (15/40), this additional information motivated a change in clinical management. In the subgroup of patients with prior 1.5T MRIs interpreted as normal, 3T PA-MRI resulted in the detection of a new lesion in 65% (15/23). In the subgroup of 15 patients with known lesions, 3T PA-MRI better defined the lesion in 33% (5/15).
  
  
  CONCLUSIONS
  Phased array surface coil studies performed at 3 Tesla read by an experienced unblinded neuroradiologist can improve the presurgical evaluation of patients with focal epilepsy when compared to routine clinical 1.5T studies read at tertiary care centers.
authors.affiliation: A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA.
authors.forename: S
authors.initials: S
authors.lastname: Knake
authors.forename: C
authors.initials: C
authors.lastname: Triantafyllou
authors.forename: L L
authors.initials: LL
authors.lastname: Wald
authors.forename: G
authors.initials: G
authors.lastname: Wiggins
authors.forename: G P
authors.initials: GP
authors.lastname: Kirk
authors.forename: P G
authors.initials: PG
authors.lastname: Larsson
authors.forename: S M
authors.initials: SM
authors.lastname: Stufflebeam
authors.forename: M T
authors.initials: MT
authors.lastname: Foley
authors.forename: H
authors.initials: H
authors.lastname: Shiraishi
authors.forename: A M
authors.initials: AM
authors.lastname: Dale
authors.forename: E
authors.initials: E
authors.lastname: Halgren
authors.forename: P E
authors.initials: PE
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods* / Q000592:standards; D011446:Prospective Studies