In vitro oocyte maturation and subsequent delayed fertilization is associated with increased embryo aneuploidy.
Failed fertilization and the appearance of immature oocytes are common in IVF practice; rescue intracytoplasmic sperm injection can be used as a therapy. However, this study indicates that embryos created after in vitro maturation and delayed intracytoplasmic sperm injection contain an increase in aneuploidy (79.7%) over control embryos (60.5%). Therefore, patients should be informed of the possible risk when presented with delayed intracytoplasmic sperm injection.
Emery
Benjamin R
BR
Division of Urology, Department of Surgery, Utah School of Medicine, Salt Lake City, Utah, USA.
Wilcox
Aaron L
AL
Aoki
Vincent W
VW
Peterson
C Matthew
CM
Carrell
Douglas T
DT
D000328:Adult; D000782:Aneuploidy; D016009:Chi-Square Distribution; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D005306:Fertilization / Q000235:genetics*; D006801:Humans; D009865:Oocytes / Q000254:growth & development / Q000502:physiology*; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013997:Time Factors