title: Multihydroxylated [Gd@C82(OH)22]n nanoparticles: antineoplastic activity of high efficiency and low toxicity.
abstract: [Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency ( approximately 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.
authors.affiliation: Lab for Bio-Environmental Health Sciences of Nanoscale Materials and Key Lab of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.forename: Gengmei
authors.initials: G
authors.lastname: Xing
authors.forename: Jiangxue
authors.initials: J
authors.lastname: Wang
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Bai
authors.initials: B
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Guang
authors.initials: G
authors.lastname: Jia
authors.forename: Tiancheng
authors.initials: T
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Sun
authors.forename: Li
authors.initials: L
authors.lastname: Xing
authors.forename: Hui
authors.initials: H
authors.lastname: Yuan
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Gao
authors.forename: Huan
authors.initials: H
authors.lastname: Meng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Chai
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Fang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D019187:Cadmium Compounds / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D037741:Fullerenes / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D007107:Immune System / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D019187:Cadmium Compounds; D037741:Fullerenes; C000608549:Gd@C82(OH)22