title: Effect of body mass index at time of transplantation and weight gain after transplantation on allograft function in kidney transplant recipients in Shiraz.
abstract: Chronic renal allograft dysfunction is the most common cause of graft loss, for which there are multiple risk factors, including obesity before transplantation, which is believed to lower long-term renal allograft survival. One hundred eighty-two kidney transplant recipients were studied. Body mass index (BMI) at the date of transplantation was calculated. BMI values were classified into 4 categories: (1) patients with BMI <20, (2) BMI between 20 and <25, (3) BMI between 25 and <30, and (4) BMI > or =30. The minimum follow-up period in this study was 3 years after transplantation. The link between categorized BMI and the presence of renal allograft dysfunction and mortality within 3 years posttransplantation was investigated using independent sample t test. BMI at the date of transplantation showed statistically significant association with presence of renal allograft dysfunction and mortality within 3 years posttransplantation (P = .008, P = .01, respectively). BMI at the date of transplantation has a strong association with outcomes after renal transplantation. The extremes of very high and very low BMI are important risk factors for chronic renal allograft dysfunction; therefore, weight adjustment before kidney transplantation can be useful in improving the function of a transplanted kidney and increasing patient's survival.
authors.affiliation: Southern Organ Transplant Center, Shiraz, Iran. ali_ra@yahoo.com
authors.forename: G A
authors.initials: GA
authors.lastname: Raiss-Jalali
authors.forename: A R
authors.initials: AR
authors.lastname: Mehdizadeh
authors.forename: A
authors.initials: A
authors.lastname: Razmkon
authors.forename: J
authors.initials: J
authors.lastname: Rouzbeh
authors.forename: S
authors.initials: S
authors.lastname: Behzadi
authors.forename: H
authors.initials: H
authors.lastname: Memari
authors.forename: S A
authors.initials: SA
authors.lastname: Malek-Hosseini
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007492:Iran; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D011184:Postoperative Period; D012189:Retrospective Studies; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000502:physiology; D015430:Weight Gain
chemical_list: D003404:Creatinine