Regulatory networks in embryo-derived pluripotent stem cells.
Mammalian development requires the specification of over 200 cell types from a single totipotent cell. Investigation of the regulatory networks that are responsible for pluripotency in embryo-derived stem cells is fundamental to understanding mammalian development and realizing therapeutic potential. Extracellular signals and second messengers modulate cell-autonomous regulators such as OCT4, SOX2 and Nanog in a combinatorial complexity. Knowledge of this circuitry might reveal how to achieve phenotypic changes without the genetic manipulation of Oct4, Nanog and other toti/pluripotency-associated genes.
Boiani
Michele
M
Max-Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Mendelstrasse 7/Von-Esmarch Strasse 56, 48149 Münster, Germany.
Schöler
Hans R
HR
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000166:cytology*; D051379:Mice; D039904:Pluripotent Stem Cells / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors