title: [Toxicity of hydroxyapatite nanoparticles on rabbits].
abstract: OBJECTIVE
  To study the toxicity of nano-hydroxyapatite on rabbits by vein.
  
  
  METHODS
  The hydroxyapatite solution was intravenous injected into 50 New Zealand white rabbits with different concentration, then to observe the reactions and the survial rates of rabbits, and to investigate the effects of nano-HA to the liver function, renal function, enzyme and Ca, Mg, P.
  
  
  RESULTS
  The medium lethal dosege of nano-HA administrated intravenous (iv) was determined as 200mg/kg. The level of phosphorous increased but calcium and magnesium kept stable. LDH, CPK, GOP and GDT dramatically increased in 30 minutes after injection, arriving the peak at 2 hours later, however, they all returned to normal 24h after injection. BUN and ALP got to the peak at 24 hours later, then decreased rapidly to normal level. The other indexes almost maintained at normal level.
  
  
  CONCLUSIONS
  Nano-hydroxyapatite has no accumulative toxicity to rabbits, it is suggested that it is safe when the hydroxyapatite-sol was applied intravenously as a drug carrier in small dosage more less than the medium lethal dose, even as a kind of anticancer drug.
authors.affiliation: Biomedical Engineering Dept, and Institute of Ultrasound Engineering in Medicine, Chongqing University of Medical Sciences, Chongqing 400016, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Liu
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Xiao
authors.forename: Zi-Wen
authors.initials: ZW
authors.lastname: Xiao
authors.forename: Zhi-Biao
authors.initials: ZB
authors.lastname: Wang
authors.forename: Chongyan
authors.initials: C
authors.lastname: Li
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Gong
mesh_terms: D000818:Animals; D017886:Durapatite / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D053758:Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D023382:Toxicity Tests, Acute
chemical_list: D017886:Durapatite