title: Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.
abstract: The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11-type peroxisome proliferators are involved in the proliferation of peroxisomes, defined here as an increase in size and/or number of peroxisomes. Dynamin-related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11-type peroxisome proliferators and dynamin-related proteins in peroxisomal proliferation and division.
authors.affiliation: Ruhr-University-Bochum, Medical Faculty, Institute of Physiological Chemistry, Bochum, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Thoms
authors.forename: Ralf
authors.initials: R
authors.lastname: Erdmann
mesh_terms: D000818:Animals; D002352:Carrier Proteins; D034281:Dynamins / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000502:physiology; D008928:Mitochondria / Q000502:physiology; D024101:Mitochondrial Proteins / Q000502:physiology; D008954:Models, Biological; D064547:Myxovirus Resistance Proteins; D000070778:Perilipin-1; D000074401:Peroxins; D020675:Peroxisomes / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology; D020033:Protein Isoforms / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D033921:Vesicular Transport Proteins
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D064547:Myxovirus Resistance Proteins; C092128:PEX11 protein, S cerevisiae; D000070778:Perilipin-1; D000074401:Peroxins; D010750:Phosphoproteins; D020033:Protein Isoforms; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins; C064553:VPS1 protein, S cerevisiae; C110768:DNM1L protein, human; D034281:Dynamins