title: Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis.
abstract: Immunosuppression associated with measles virus (MV) can be demonstrated by cytokine production failure in subacute sclerosing panencephalitis (SSPE) and may have implications on the pathogenesis of the disease. Cytokines (IL-12, IL-10, IL-4, IL-17, IL-18, IFN-alpha, IFN-gamma) and chemokines (CXCL8, CXCL10, CCL2 and CCL5) were measured in the cerebrospinal fluid (CSF) and serum samples from 60 patients with SSPE, 36 patients with infectious and/or inflammatory (IN) and 28 with other non-inflammatory (NIN) neurological diseases by ELISA. IL-12 p70+p40 was elevated in CSF and sera of SSPE when compared to the NIN group. However, the CSF levels of IL-12 p70 alone were not increased, indicating an increase of p40. The CSF of SSPE patients also showed relatively higher levels of IL-10 than that of the NIN group. CXCL10 levels in CSF were significantly higher in SSPE, whereas CXCL8 was increased in sera compared to NIN. No difference was detected in IFN-gamma, IFN-alpha, IL-17, IL-18, IL-4 or CCL2 and CCL5 levels. These results demonstrate that immune response against MV in SSPE may be impaired, although some T cell/Th1 inducing stimulations are present.
authors.affiliation: Department of Physiology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey. gsaruhan@istanbul.edu.tr
authors.forename: Güher
authors.initials: G
authors.lastname: Saruhan-Direskeneli
authors.forename: Candan
authors.initials: C
authors.lastname: Gürses
authors.forename: Veysi
authors.initials: V
authors.lastname: Demirbilek
authors.forename: Sibel P
authors.initials: SP
authors.lastname: Yentür
authors.forename: Gülden
authors.initials: G
authors.lastname: Yilmaz
authors.forename: Emel
authors.initials: E
authors.lastname: Onal
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Yapici
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yalçinkaya
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cokar
authors.forename: Gülşen
authors.initials: G
authors.lastname: Akman-Demir
authors.forename: Ayşen
authors.initials: A
authors.lastname: Gökyiğit
mesh_terms: D054357:Chemokine CXCL10; D018925:Chemokines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D019743:Chemokines, CXC / Q000097:blood / Q000134:cerebrospinal fluid*; D002648:Child; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D018664:Interleukin-12 / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood* / Q000134:cerebrospinal fluid*
chemical_list: D054357:Chemokine CXCL10; D018925:Chemokines; D019743:Chemokines, CXC; D016207:Cytokines; D018664:Interleukin-12