title: Characteristics of vitamin C immobilized particles and sodium alginate beads containing immobilized particles.
abstract: This paper reports the properties of vitamin C encapsulated sodium alginate beads prepared by an alternative approach. The alternative encapsulation process mainly involves immobilization of vitamin C in hydrated zinc oxide layers and encapsulation of prepared immobilized particles in sodium alginate bead. The immobilization of vitamin C in hydrated zinc oxide layers was achieved by a coprecipitation process. Fourier transform infrared (FTIR) spectroscopy showed that the vitamin C was found to be stable after its immobilization. X-ray diffraction (XRD) studies revealed that anionic vitamin C molecules are adsorbed between positively charged zinc hydroxide layers with a 1:1 layer sequence, since well-defined change in basal spacing was observed. Well-defined change in surface morphology was observed by scanning electron microscopy (SEM) when vitamin C immobilized particles are encapsulated in sodium alginate bead. The biological activity of vitamin C was retained, even after its immobilization which was confirmed by 4-dihydroxy-L-phenylalanine (L-DOPA) oxidase inhibition and free radical scavenging activity studies. The release rate of vitamin C from immobilized particles and beads was sustained through an ion exchange process. A higher amount of stable vitamin C was recovered from the bead when compared to neat vitamin C itself.
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, Sungbuk-ku, Seoul, South Korea.
authors.forename: K G H
authors.initials: KG
authors.lastname: Desai
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D014442:Monophenol Monooxygenase; D001205:Ascorbic Acid; D015034:Zinc Oxide