title: Differences between patients', physicians' and pharmacists' preferences for treatment products in haemophilia: a discrete choice experiment.
abstract: The provision of health care to patients with haemophilia through replacement of the deficient coagulation factor is the result of a complex interaction between patients, physicians and policy makers, each carrying their individual sets of preferences. Preferences of patients, physicians and pharmacists towards perceived viral safety, risk of inhibitor development, infusion frequency during prophylaxis, pharmaceutical dosage form, distribution modes and price were evaluated by conjoint analysis, using a discrete choice experiment. Overall 178 patients', 69 physicians and 58 pharmacists completed the study. Patients, physicians and pharmacists displayed preferences: (i) similar in direction and strength for risk of inhibitors and frequency of prophylaxis, (ii) similar in direction, but not in strength for perceived viral safety and price, with patients showing lower strength compared with physicians and pharmacists, and (iii) dissimilar in direction and/or strength for: (i) dosage form, which tested important only for pharmacists and (ii) distribution mode, which tested important for patients and physicians only. Our study provides evidence of the differences between different stakeholders in the preferences towards haemophilia replacement therapy, indicating that different opinions should be taken into account when planning optimal care.
authors.affiliation: Centre of Pharmacoeconomics, Department of Pharmacological Sciences, University of Milan, Italy. lorenzo.mantovani@unimi.it
authors.forename: L G
authors.initials: LG
authors.lastname: Mantovani
authors.forename: M S
authors.initials: MS
authors.lastname: Monzini
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
authors.forename: L
authors.initials: L
authors.lastname: Scalone
authors.forename: M
authors.initials: M
authors.lastname: Villa
authors.forename: A
authors.initials: A
authors.lastname: Gringeri
mesh_terms: D000293:Adolescent; D000328:Adult; D001291:Attitude of Health Personnel; D002755:Choice Behavior; D015331:Cohort Studies; D005164:Factor IX / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005169:Factor VIII / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy / Q000523:psychology*; D002836:Hemophilia B / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010595:Pharmacists / Q000523:psychology; D010820:Physicians / Q000523:psychology; D012720:Severity of Illness Index
chemical_list: D005169:Factor VIII; D005164:Factor IX