Lack of association between interferon-gamma receptor-1 polymorphism and pulmonary TB in Iranian population sample.
BACKGROUND
Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-gammaR1.


OBJECTIVE
Determination of susceptibility to tuberculosis with polymorphism of IFN-gammaR1 gene.


METHODS
Study was prospective case-control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-gammaR1 gene was detected with Newport method. Data were analysed with SPSS version 11.


RESULTS
Mean age of patients and control were 55+/-20 and 53+/-13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-gammaR1 gene. In control group there were no mutations.


CONCLUSIONS
Genetically susceptibility to TB is not in 395 colon of IFN-gammaR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population.
Mirsaeidi
S M
SM
National Research Institute of Tuberculosis and Lung Disease, Tehran, Iran. mmirsaeidi@nritld.ac.ir
Houshmand
M
M
Tabarsi
P
P
Banoei
M M
MM
Zargari
L
L
Amiri
M
M
Mansouri
S D
SD
Sanati
M H
MH
Masjedi
M R
MR
D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D017471:Receptors, Interferon / Q000235:genetics*; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000235:genetics*; D000096743:Interferon gamma Receptor
D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor