[Uric acid as a marker of pathophysiological mechanisms in patients with cardiovascular disease].
Uric acid can serve as a marker of pathophysiological mechanisms in patients with cardiovascular disease, which may explain why serum uric acid contains prognostic information. Uric acid is the end product of purine degradation. It is catalyzed by the enzyme xanthin oxidase, which is responsible for the production of uric acid and damaging free radicals. This is a central link in the association between serum uric acid and myocardial ischemia, myocardial dysfunction and non-cardial function, which is determined primarily by impaired peripheral blood flow. Inhibition of xanthin oxidase with allopurinol may be used in future treatment of heart patients.
Calberg
Maiken J
MJ
Amtssygehuset i Herlev, Akutmedicinsk Kardiologisk Afdeling S.
Kjøller
Erik
E
D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology; D006801:Humans; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology; D011379:Prognosis; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid