Current and potential uses of imiquimod.
Imiquimod, an imidazoquinoline amine, is an immune response modifier first FDA-approved for the treatment of external genital and perianal warts in 1997. Since its appearance on the market, its antiviral and antitumor properties have been used in the treatment of a variety of dermatologic conditions. In this review article, the basic mechanism of action of imiquimod, current FDA-approved and non-FDA-approved uses of imiquimod, and key points of medication application frequency, possible adverse effects, and use in combination therapy are discussed. Common skin conditions that may be eradicated with imiquimod are emphasized.
Chang
Yuchi C
YC
Department of Intemal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Madkan
Vandana
V
Cook-Norris
Robert
R
Sra
Karan
K
Tyring
Stephen
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000634:Aminoquinolines / Q000494:pharmacology / Q000627:therapeutic use*; D006558:Herpes Genitalis / Q000188:drug therapy; D018258:Herpesvirus 2, Human; D006801:Humans; D000077271:Imiquimod; D009369:Neoplasms / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D013653:Tattooing
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod