Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia.
Acquired Glanzmann's thrombasthenia is an uncommon event in association with leukemia. The authors describe a patient with acute lymphoblastic leukemia (ALL) who presented with severe hemorrhagic syndrome, without disseminated intravascular coagulation. The patient's course was complicated by the occurrence of severe hemorrhagic episodes, with a thrombasthenia-like profile, requiring multiple transfusions with packed red cells, platelets, and fresh-frozen plasma. Biological explorations detected anti-GPIIb/IIIa complex antibodies. The patient finally died with refractory disease and persistent bleeding. This case is the first reported of autoantibodies to GPIIb/IIIa in ALL. Such paraneoplastic syndrome is potentially responsible for severe life-threatening hemorrhage.
André
Jean-Marie
JM
Hospices Civils de Lyon, Hôpital Debrousse, Service d'Onco-Hématologie Pédiatrique, Lyon, France. eli.jm@club-internet.fr
Galambrun
Claire
C
Trzeciak
Marie-Christine
MC
Dargaud
Yesim
Y
Kaplan-Gouet
Cécile
C
Jallu
Vincent
V
Bertrand
Yves
Y
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D016913:Blood Component Transfusion; D017809:Fatal Outcome; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000276:immunology / Q000628:therapy; D013915:Thrombasthenia / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D017211:Treatment Failure
D001323:Autoantibodies; D019039:Platelet Glycoprotein GPIIb-IIIa Complex