Chip devices for miniaturized biotechnology.
Chip devices were introduced in chemistry and molecular biology to improve the read-out of information from molecular systems by efficient analytical procedures and to organize automated experiments. Biochips and chip reactor systems are of interest for cellular processes, too, and can be regarded as components in interfaces for the information exchange between living nature and digital electronic systems. In this minireview, different types of chip reactors for biotechnological applications like nanotiterplates, chip thermocyclers and devices for segmented flow operations are discussed. Finally, an outlook is given on the application of chip reactor systems, which are promising tools for automated experiments with highly parallelized screening procedures, for artificial microcompartmentation, cell analogue systems, micro-ecological studies, investigations on modulated morphogenesis, and for a bioanalogue molecular nanotechnology.
Köhler
J Michael
JM
Technische Universität Ilmenau, Institut für Physik, Fachgebiet Physikalische Chemie/Mikroreaktionstechnik, Stiftungslehrstuhl der Deutschen Bundesstiftung Umwelt, Germany. michael.koehler@tu-ilmenau.de
Henkel
Thomas
T
D000818:Animals; D001419:Bacteria / Q000254:growth & development; D019149:Bioreactors; D001709:Biotechnology / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D005898:Glass; D006801:Humans; D008422:Materials Testing; D046208:Microchip Analytical Procedures; D044085:Microfluidics; D049329:Nanostructures; D012825:Silicon
D012825:Silicon