Role of Thy 1,2+ cells in the regulation of hemopoiesis during experimental neuroses.
We studied the direct and stromal cell-mediated effects of bone marrow Thy 1,2+ cells on the growth of granulocyte-macrophage and erythroid colonies from the bone marrow of CBA/CaLac mice with experimental neuroses (conflict situation and paradoxical sleep deprivation). Proliferation and differentiation of hemopoietic precursors during neuroses are controlled by regulatory T cells. In conflict situation Thy 1,2+ cells stimulate the growth of hemopoietic precursors, which is associated with their direct effect and interaction with adherent cells of the hemopoiesis-inducing microenvironment. The interaction of Thy 1,2+ cells with adherent bone marrow cells during paradoxical sleep deprivation stimulates the formation of only granulocyte-macrophage colonies.
Skurikhin
E G
EG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Pershina
O V
OV
Suslov
N I
NI
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D002454:Cell Differentiation; D049109:Cell Proliferation; D003114:Colony-Forming Units Assay; D015672:Erythroid Precursor Cells / Q000502:physiology*; D006098:Granulocytes / Q000473:pathology; D006410:Hematopoiesis / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D009497:Neurotic Disorders / Q000503:physiopathology* / Q000523:psychology; D012892:Sleep Deprivation / Q000503:physiopathology / Q000523:psychology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*