title: Intraepithelial mucinous carcinoma arising in an endocervical-type mucinous polypoid adenomyoma of the uterine corpus: a case report.
abstract: BACKGROUND
  Benign endocervical-type mucinous adenomyoma arising in the uterine corpus is a rare entity. We report a case of intraepithelial mucinous adenocarcinoma arising in an endocervical-type mucinous adenomyoma of the uterine corpus in a previously healthy woman.
  
  
  METHODS
  A 55-year-old, white woman presented with postmenopausal bleeding. Uterine leiomyomas and endometrial polyps were suggested by ultrasonography. Endometrial curettage showed multiple polypoid tissue fragments, each composed of glands lined with tall columnar endocervical-type mucinous epithelium lying within a background of endometrial-type stroma and smooth muscle fibers. The mucinous glandular epithelium showed a spectrum of architectural and cytologic changes ranging from benign to severe atypia and occasional back-to-back cribriform glands, consistent with adenocarcinoma. The surrounding smooth muscle fibers and endometrial stromal cells were benign. A diagnosis was made of intraepithelial adenocarcinoma arising in a mucinous adenomyoma in the uterine corpus.
  
  
  CONCLUSIONS
  Endocervical-type mucinous adenomyoma, although previously reported as a benign entity, may contain areas of adenocarcinoma.
authors.affiliation: Department of Pathology, Women & Infants Hospital and Brown University Medical School, Providence, RI 02905-2499, USA. mquddus@wihri.org
authors.forename: M Ruhul
authors.initials: MR
authors.lastname: Quddus
authors.forename: Cunxian
authors.initials: C
authors.lastname: Zhang
authors.forename: C James
authors.initials: CJ
authors.lastname: Sung
authors.forename: Donald
authors.initials: D
authors.lastname: Ramos
authors.forename: W Dwayne
authors.initials: WD
authors.lastname: Lawrence
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018194:Adenomyoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D004717:Endometrium / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D017403:In Situ Hybridization; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011127:Polyps / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014592:Uterine Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery