title: Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli.
abstract: A time-course gene-expression profile was generated for Escherichia coli TK31 when it was exposed to an organic solvent mixture, and classified by fuzzy adaptive resonance theory (Fuzzy ART). It was found that the purR regulon plays an important role in the organic solvent tolerance (OST) of E. coli.
authors.affiliation: Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimizu
authors.forename: Shuhei
authors.initials: S
authors.lastname: Hayashi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Doukyu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honda
mesh_terms: D004361:Drug Tolerance / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D017143:Fuzzy Logic; D020869:Gene Expression Profiling / Q000379:methods*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects / Q000502:physiology; D008657:Metabolic Clearance Rate; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D009930:Organic Chemicals / Q000494:pharmacology*; D018085:Regulon / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012997:Solvents / Q000494:pharmacology*
chemical_list: D029968:Escherichia coli Proteins; D009930:Organic Chemicals; C489317:PurR protein, E coli; D012097:Repressor Proteins; D012997:Solvents