title: Effects of long-term oral administration of ketoprofen in clinically healthy beagle dogs.
abstract: To investigate the adverse effects of long-term administration of ketoprofen in dogs, ketoprofen (1 mg/kg) was administered to five clinically healthy beagle dogs (ketoprofen group) and gelatin capsules (control group) were administered to four clinically healthy beagle dogs for 30 days. We monitored the dogs through periodic physical examination, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests, urinalysis, urinary enzyme indices and cuticle bleeding time analysis. The lesions in the stomach, especially in the pyloric antrum, and fecal occult blood progressively worsened in the ketoprofen group. However, the differences between the ketoprofen group and the control group were not statistically significant. One dog in the ketoprofen group temporarily exhibited a decrease in renal plasma flow and two dogs exhibited enzymuria. However, these changes did not persist and the other examinations showed no significant difference between premedication and postmedication in the ketoprofen group. Therefore, the adverse effects of long-term administration of ketoprofen observed in this study were not clinically important in healthy dogs. Nevertheless, further investigation of adverse renal effects from long-term administration of ketoprofen is necessary in the dogs with subclinical renal disease.
authors.affiliation: Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Narita
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tomizawa
authors.forename: Reeko
authors.initials: R
authors.lastname: Sato
authors.forename: Masanobu
authors.initials: M
authors.lastname: Goryo
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hara
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000633:toxicity; D001760:Bleeding Time / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005243:Feces / Q000737:chemistry; D005260:Female; D005773:Gastroscopy / Q000662:veterinary; D006470:Hemorrhage / Q000139:chemically induced / Q000662:veterinary*; D007660:Ketoprofen / Q000009:adverse effects* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects*; D008297:Male; D011706:Pyloric Antrum / Q000187:drug effects*; D013272:Stomach Diseases / Q000139:chemically induced / Q000662:veterinary*; D016482:Urinalysis / Q000662:veterinary
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen