title: Novel prenyltransferase enzymes as a tool for flavonoid prenylation.
abstract: The recent identification of genes encoding a novel family of soluble aromatic prenyltransferases from Streptomyces species and the structural characterization of one of these proteins are challenging discoveries in the biochemistry of natural compounds. In addition to their notable physiological role in the biosynthesis of aminocoumarin antibiotics, these enzymes represent an advanced tool for exploring novel isoprenoid substitutions in aromatic compounds and are expected to foster the emerging pharmacological applications of prenylated flavonoids.
authors.affiliation: Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, 00185 Roma, Italy. bruno.botta@uniroma1.it
authors.forename: Bruno
authors.initials: B
authors.lastname: Botta
authors.forename: Giuliano
authors.initials: G
authors.lastname: Delle Monache
authors.forename: Pilar
authors.initials: P
authors.lastname: Menendez
authors.forename: Alberto
authors.initials: A
authors.lastname: Boffi
mesh_terms: D004122:Dimethylallyltranstransferase / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry*; D017368:Protein Prenylation; D013302:Streptomyces / Q000201:enzymology*; D013379:Substrate Specificity
chemical_list: D005419:Flavonoids; D004122:Dimethylallyltranstransferase