The effect of a nicorandil congener on isolated human myometrium.
OBJECTIVE
To determine the effect of a nicorandil congener, SG-209 on the myometrium.


METHODS
Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.0 and 10 microM). The mean height of contraction and the area under the curve were analysed using a non-parametric test.


RESULTS
At a 10 microM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p<0.05).


CONCLUSIONS
SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.
Parimala
K
K
Department of Pharmacology, Christian Medical College, Vellore, India.
Peedicayil
Jacob
J
Peedicayil
Abraham
A
Nelson
Nissy
N
Ernest
Kalpana
K
D000328:Adult; D019540:Area Under Curve; D004412:Dysmenorrhea / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009215:Myometrium / Q000187:drug effects*; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
D009536:Niacinamide; C035663:SG 209