Leptin sensitivity in skeletal muscle is modulated by diet and exercise.
Leptin reduces intracellular lipid stores and improves insulin sensitivity. Thus, the development of leptin resistance in obesity may be an early event leading to elevated intramuscular lipids and insulin resistance. Recent data indicate that obesity-causing high-fat diets lead to leptin resistance in muscle, whereas supplementation with dietary fish oil and aerobic training can partially reverse this resistance.
Dyck
David J
DJ
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
D000818:Animals; D004041:Dietary Fats / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009765:Obesity / Q000503:physiopathology
D004041:Dietary Fats; D005227:Fatty Acids; D020738:Leptin