title: Increased antibacterial activity of zinc polycarboxylate cement by the addition of chlorhexidine gluconate in fixed prosthodontics.
abstract: OBJECTIVE
  This study evaluated the antibacterial activity of water-activated zinc polycarboxylate cement with adjunctive 0.12% chlorhexidine gluconate on the subgingival microbiota in fixed partial dentures.
  
  
  METHODS
  Thirty-six teeth prepared as fixed partial denture abutments in 9 patients were cemented randomly using water-activated zinc polycarboxylate cement (control group) or water-activated zinc polycarboxylate cement, including 0.12% chlorhexidine gluconate (test group). A total of 108 subgingival plaque samples were analyzed at baseline, immediately before permanent cementation (5 weeks), and 8 weeks later (at 13 weeks).
  
  
  RESULTS
  In the control group, the subgingival microbiota altered to closely resemble the flora of chronic gingivitis (increased proportions of gram-negative anaerobes such as Prevotella intermedia, Fusobacterium nucleatum) by 13 weeks. In contrast, the microflora at test sites comprised predominantly gram-positive facultative cocci and rods at 13 weeks.
  
  
  CONCLUSIONS
  This study demonstrated that the addition of 0.12% chlorhexidine gluconate may enhance the antimicrobial action of polycarboxylate cements to ensure the maintenance of a microflora compatible with periodontal health, at least up to 13 weeks post-cementation.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey. berrinorug@yahoo.com
authors.forename: Berrin Ors
authors.initials: BO
authors.lastname: Orug
authors.forename: Mehmet
authors.initials: M
authors.lastname: Baysallar
authors.forename: Deniz
authors.initials: D
authors.lastname: Cetiner
authors.forename: Ayten
authors.initials: A
authors.lastname: Kucukkaraaslan
authors.forename: Berna
authors.initials: B
authors.lastname: Dogan
authors.forename: Levent
authors.initials: L
authors.lastname: Doganci
authors.forename: Eralp
authors.initials: E
authors.lastname: Akca
authors.forename: Belgin
authors.initials: B
authors.lastname: Bal
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002484:Cementation; D016009:Chi-Square Distribution; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology; D003830:Denture, Partial, Fixed; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D011076:Polycarboxylate Cement / Q000737:chemistry*
chemical_list: D000891:Anti-Infective Agents, Local; D011076:Polycarboxylate Cement; C010882:chlorhexidine gluconate; D002710:Chlorhexidine