title: Old method, new drugs: comparison of the efficacy of sevoflurane, isoflurane, and desflurane in achieving controlled hypotension in spinal surgery.
abstract: This study compared the efficacy of isoflurane, sevoflurane, and desflurane in achieving hemodynamic stability in spinal procedures using moderate levels of controlled hypotension. After obtaining ethics committee approval and written informed consent, 32 American Surgical Association I-II patients were randomly allocated to receive isoflurane (n=12), sevoflurane (n=10), or desflurane (n=10) in O2-N2O (1:1) for maintenance of anesthesia. The induction of anesthesia, fentanyl dosage, and initial and maintenance volume replacements were standardized. Blood pressure was invasively monitored and maintained within a target systolic blood pressure (SBP) range of 80 to 90 mm Hg during the study. SBP outside this range was recorded. Volatile anesthetic concentration was adjusted according to the same protocol for all 3 agents. SPB control was maintained better with sevoflurane and isoflurane than desflurane; median SBP was outside the target range during 32% (range, 15%-55%) of study time with isoflurane, 26% (12%-42%) with sevoflurane, and 44% (20%-80%) with desflurane. Total blood loss did not differ among the groups. Sevoflurane and isoflurane administered in 2 L/min fresh gas flow were more effective than desflurane in achieving controlled hypotension in spinal surgery.
authors.affiliation: Department of Anesthesiology and Reanimation, Department of Neurosurgery, Ege University Hospital, Izmir, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Kurt
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Derbent
authors.forename: Kubilay
authors.initials: K
authors.lastname: Demirag
authors.forename: Oguz
authors.initials: O
authors.lastname: Eris
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uyar
authors.forename: Sertac
authors.initials: S
authors.lastname: Islekel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000494:pharmacology / Q000627:therapeutic use*; D000077335:Desflurane; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D008738:Methyl Ethers / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D000077149:Sevoflurane; D013122:Spinal Diseases / Q000601:surgery*; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane