title: Invasive aspergillosis of the central nervous system after allogeneic stem cell transplantation.
abstract: Central nervous system aspergillosis is a rare infectious complication in patients submitted to allogeneic stem cell transplantation. When it arises, this infection appears early post-transplant and most patients present with multiple central nervous system lesions. We report the clinical case of a 52 year old woman with IgGk multiple myeloma in relapse after a matched related allogeneic bone marrow transplant, who presented with a single large central nervous system Aspergillus lesion 11 months post-transplant in the setting of acute graft vs. host disease developing after the infusion of donor leucocytes. Although liposomal amphotericin B was promptly instituted, the patient died 1 week after the diagnosis.
authors.affiliation: Hematology, Neurosurgery and Radiology Services, Hospital de Santa Maria, University of Lisbon, Lisbon, Portugal. jflacerda@netcabo.pt
authors.forename: João F
authors.initials: JF
authors.lastname: Lacerda
authors.forename: Carlos
authors.initials: C
authors.lastname: Martins
authors.forename: José A
authors.initials: JA
authors.lastname: Carmo
authors.forename: F
authors.initials: F
authors.lastname: Lourenço
authors.forename: M Moura
authors.initials: MM
authors.lastname: Guedes
authors.forename: Paulo
authors.initials: P
authors.lastname: Sequeira
authors.forename: J M F
authors.initials: JM
authors.lastname: Lacerda
mesh_terms: D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000382:microbiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology; D020314:Central Nervous System Fungal Infections / Q000000981:diagnostic imaging / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011859:Radiography; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous / Q000009:adverse effects*