[Effect of zinc on thymulin level in mice].
OBJECTIVE
In order to investigate the roles of the different levels of zinc nutrition status on the thymulin of the mice.


METHODS
The experiment included two periods: zinc depleted period and repletion period. In the depleted period, mice were divided into 3 dose groups: zinc deficient group (ZD, 5.2 mg/kg), zinc pair-fed group (PZ) and normal zinc group(NZ,25.6 mg/kg). In the repletion period, mice were divided into 3 dose groups: ZD group, DZ-NZ group and PZ-NZ group.


RESULTS
The results showed that a signification decrease of thymulin level was observed as a result of zinc deficiency and was increased rapidly follow zinc supplement, while the plasma zinc was kept the same level.


CONCLUSIONS
The thymulin is a sensitive biomarker for assess the zinc status.
Chen
Jing
J
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Qu
Ning
N
Xia
Yi-Ming
YM
D000818:Animals; D015415:Biomarkers / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013935:Thymic Factor, Circulating / Q000032:analysis*; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency* / Q000494:pharmacology*
D015415:Biomarkers; D013935:Thymic Factor, Circulating; D015032:Zinc