title: Cytotoxic activities of ethyl acetate extract and a metabolite from a Monocillium species.
abstract: The ethyl acetate soluble fraction of a cultural broth of a Monocillium species afforded the isolation of 5-hydroxymethylfurfural. Both the extract and 5-hydroxymethylfurfural showed significant cytotoxic activities in a brine shrimp bioassay and the LC(50) values were found to be 14.96 microg/mL and 23.71 microg/mL, respectively.
authors.affiliation: Department of Pharmacy, University of Rajshahi, Bangladesh.
authors.forename: Proma
authors.initials: P
authors.lastname: Khondkar
authors.forename: M Mukhlesur
authors.initials: MM
authors.lastname: Rahman
authors.forename: Anwarul
authors.initials: A
authors.lastname: Islam
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001156:Artemia / Q000187:drug effects; D005662:Furaldehyde / Q000031:analogs & derivatives / Q000633:toxicity; D007928:Lethal Dose 50; D003904:Mitosporic Fungi / Q000378:metabolism*; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde