Successful clinical application of extracorporal albumin dialysis in a patient with benign recurrent intrahepatic cholestasis (BRIC).
This is a case report of a 36 years old man who has been suffering for 20 years from benign recurrent intrahepatic cholestasis (BRIC). BRIC is a rare autosomal recessive disease characterised by prolonged episodes of intrahepatic cholestasis and pruritus alternating with periods of nearly normal liver function, and does not progress to cirrhosis. Since all former approaches to medical treatment of the patients severe pruritus were ineffective, the patient was treated by 3 sessions of albumin dialysis (MARS, Molecular Adsorbents Recirculating System). MARS dialysis decreased serum bilirubin levels by more than 60 % and effectively lowered serum bile acid levels by 45 %. The course of serum parameters was accompanied by a dramatic clinical improvement of the patients symptoms (pruritus, jaundice, fatigue etc.). MARS therapy appeared to shorten the duration of the cholestatic attack.
Huster
D
D
Department of Medicine I and II, University of Leipzig, Philipp-Rosenthal-Strasse 27, 04103 Leipzig. husterd@medizin.uni-leipzig.de
Schubert
C
C
Achenbach
H
H
Caca
K
K
Mössner
J
J
Berr
F
F
D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D002780:Cholestasis, Intrahepatic / Q000517:prevention & control*; D005112:Extracorporeal Circulation / Q000379:methods*; D006801:Humans; D008297:Male; D020127:Recovery of Function; D006435:Renal Dialysis / Q000379:methods*; D055502:Secondary Prevention; D012709:Serum Albumin / Q000302:isolation & purification*; D016896:Treatment Outcome
D012709:Serum Albumin