title: Regulating mammalian transcription with RNA.
abstract: Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA. david.corey@utsouthwestern.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Corey
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D006801:Humans; D008322:Mammals; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D010944:Plants / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012313:RNA; D004247:DNA