Electrospray ionization mass spectrometry study on dipeptide 4-chlorobutyl ester produced from refluxing of amino acid with phosphoryl chloride in tetrahydrofuran.
Phosphoryl chloride was able to promote the formation of peptide and the ringopening of tetrahydrofuran (THF) followed by a sequence of successive reactions by simply refluxing. ESI multistage tandem mass spectrometry was applied to trace the reaction and elucidate the product structures, dipeptide 4-chlorobutyl ester.
Zhou
Gui Ji
GJ
Department of Chemistry and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, 361005, P.R. China.
Liu
Ze
Z
Wang
Tong Jian
TJ
Xu
Peng Xiang
PX
Tang
Gou
G
Ye
Yong
Y
Zhao
Yu Fen
YF
D000596:Amino Acids / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D017553:Phosphorus Compounds / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D000596:Amino Acids; D004151:Dipeptides; D005663:Furans; D017553:Phosphorus Compounds; D012997:Solvents; C018674:tetrahydrofuran; C013196:phosphoryl chloride