[Estimation of antioxidative effect of atorvastatin and fluvastatin used in primary prevention of coronary heart disease--effect on antioxidative enzymatic activity].
The effect of atorvastatin and fluvastatin on antioxidative enzymatic activity was studied in CHD risk patients. The study comprised 35 patients (20 men and 15 women) aged 35-47 years, who were allotted into two groups: I--18 patients were administered fluvastatin (Lescol) in a dose of 40 mg once daily at bed time for 6 weeks and II--17 patients were administered atorvastatin (Sortis) in a dose of 10 mg once daily at bed time for 6 weeks. The control group consisted of 12 clinically healthy subjects, aged 34-42 years. SOD-1, GSH-Px and CAT activity in erythrocytes was measured. Greater increase of low erythrocyte antioxidative enzymatic activity was observed in atorvastatin than in fluvastatin group.
Kowalski
Jan
J
Z Katedry Rehabilitacji z Klinika Chorób Wewnetrznych i Rehabilitacji Kardiologicznej, Uniwersytetu Medycznego, Lodzi.
Pawlicki
Lucjan
L
Grycewicz
Joanna
J
Błaszczyk
Jan
J
Irzmańiski
Robert
R
Ceglińiski
Tomasz
T
Kowalczyk
Edward
E
Liban-Gałka
Beata
B
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D000069059:Atorvastatin; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D000077340:Fluvastatin; D006538:Heptanoic Acids / Q000008:administration & dosage*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011322:Primary Prevention; D011758:Pyrroles / Q000008:administration & dosage*; D016896:Treatment Outcome
D000975:Antioxidants; D005229:Fatty Acids, Monounsaturated; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D011758:Pyrroles; D000077340:Fluvastatin; D000069059:Atorvastatin