Multidrug-resistant tuberculosis detection, Latvia.
To improve multidrug-resistant tuberculosis (MDR-TB) detection, we successfully introduced the rpoB gene mutation line probe assay into the national laboratory in Latvia, a country with epidemic MDR-TB. The assay detected rifampin resistance with 91% sensitivity and 96% specificity within 1 to 5 days (vs. 12-47 days for BACTEC).
Skenders
Girts
G
State Centre of Tuberculosis and Lung Diseases, Riga, Latvia.
Fry
Alicia M
AM
Prokopovica
Inga
I
Greckoseja
Silvija
S
Broka
Lonija
L
Metchock
Beverly
B
Holtz
Timothy H
TH
Wells
Charles D
CD
Leimane
Vaira
V
D000995:Antitubercular Agents / Q000494:pharmacology; D006801:Humans; D007844:Latvia / Q000453:epidemiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*
D000995:Antitubercular Agents