title: Treatment of chronic rhinosinusitis with low-dose, long-term macrolide antibiotics: an evolving paradigm.
abstract: The 14-membered and 15-membered ring macrolide antibiotics express immunomodulatory effects in chronic respiratory disorders in humans that are distinct from their antimicrobial properties. These drugs downregulate the excessive immune and inflammatory responses observed in these conditions while promoting tissue repair. To this end, chronic rhinosinusitis is characterized by mucosal inflammation of nasal and sinus mucosa for more than 3 months and accounts for significant health care resource allocation due to difficulties in treatment. Clinical efficacy of macrolide antibiotics as biologic response modifiers in patients with chronic rhinosinusitis is suggested by compelling basic research and small, uncontrolled clinical studies. Hence, long-term, prospective double-blind placebo-controlled clinical studies are indicated to establish the utility of these drugs in the treatment of patients with chronic rhinosinusitis.
authors.affiliation: Department of Medicine (M/C 719), University of Illinois at Chicago, 840 South Wood Street, Room 913, Chicago, IL 60616-7323, USA.
authors.forename: Umur
authors.initials: U
authors.lastname: Hatipoglu
authors.forename: Israel
authors.initials: I
authors.lastname: Rubinstein
mesh_terms: D000818:Animals; D002908:Chronic Disease; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D018942:Macrolides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D012220:Rhinitis / Q000188:drug therapy* / Q000473:pathology; D012852:Sinusitis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007155:Immunologic Factors; D018942:Macrolides