Two-way traffic: centrosomes and the cell cycle.
The well recognized activities of the mammalian centrosome--microtubule nucleation, duplication, and organization of the primary cilium--are under the control of the cell cycle. However, the centrosome is more than just a follower of the cell cycle; it can also be essential for the cell to transit G1 and enter S phase. How the centrosome influences G1 progression is a mystery.
Sluder
Greenfield
G
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01605, USA. greenfield.sluder@umassmed.edu
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018385:Centrosome / Q000378:metabolism* / Q000648:ultrastructure; D008866:Microsurgery; D015398:Signal Transduction / Q000502:physiology