Evaluation of the efficacy of emodepside plus praziquantel topical solution against ascarid infections (Toxocara cati or Toxascaris leonina) in cats.
Eleven controlled studies were conducted in the United States and Europe to evaluate the efficacy of a topical solution of emodepside (3 mg/kg)+praziquantel (12 mg/kg) (Profender, Bayer AG, Leverkusen, Germany) against infection with various stages of the ascarid nematodes Toxocara cati and Toxascaris leonina. Infections were induced by administration of larvated ascarid eggs, and stage-specific efficacy was evaluated by treating cats at scheduled intervals post-inoculation. All studies featured random allocation to treatment groups, placebo-treated control animals and assessment of outcome measures by masked personnel. The product (emodepside+praziquantel topical solution) was 100% effective against mature adults and immature adult T. cati. In addition, it was 96.8% effective against third stage larvae and at least 99.4% effective against fourth stage larvae of T. cati, respectively. Efficacy against mature, immature adult and L4 stages of T. leonina exceeded 93.4%, but regulatory "adequacy of infection" criteria were not met in some studies. No adverse reactions to treatment were noted in cats treated with the emodepside+praziquantel topical solution.
Reinemeyer
C R
CR
East Tennessee Clinical Research, Knoxville, Tennessee, USA. creinemey@aol.com.
Charles
S D
SD
Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
Buch
J
J
Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
Settje
T
T
Bayer HealthCare LLC, Animal Health Division, Kansas, USA.
Altreuther
G
G
Bayer HealthCare AG, Animal Health Division, R&D Parasiticides, 51368, Leverkusen, Germany.
Cruthers
L
L
Professional Laboratory Research Services, North Carolina, USA.
McCall
J W
JW
TRS Laboratories, Georgia, USA.
Young
D R
DR
Young Veterinary Research Services, Turlock, Callfornia, USA.
Epe
C
C
Institute of Parasitology, Hannover School of Veterinary Medicine, Hannover, Germany.
D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D047630:Depsipeptides / Q000008:administration & dosage* / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D011223:Praziquantel / Q000008:administration & dosage* / Q000627:therapeutic use*; D014119:Toxocara / Q000145:classification / Q000187:drug effects; D014120:Toxocariasis / Q000188:drug therapy*
D000871:Anthelmintics; D047630:Depsipeptides; D011223:Praziquantel; C468987:emodepside