Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.
Park
Hye-Seong
HS
Department of Physiology, School of Medicine, Ajou University, Suwon, Kyungkido 442-749, Republic of Korea.
Lee
Bo Kyung
BK
Park
Sok
S
Kim
Seung U
SU
Lee
Soo Hwan
SH
Baik
Eun Joo
EJ
Lee
Sunkyung
S
Yi
Kyu Yang
KY
Yoo
Sung Eun
SE
Moon
Chang-Hyun
CH
Jung
Yi-Sook
YS
D000818:Animals; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002545:Brain Ischemia / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005110:Extracellular Space / Q000187:drug effects; D018698:Glutamic Acid / Q000009:adverse effects; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D016202:N-Methylaspartate / Q000009:adverse effects; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D015424:Reperfusion / Q000379:methods; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors*; D013778:Tetrazolium Salts; D013844:Thiazoles
D006146:Guanidines; D017923:Sodium-Hydrogen Exchangers; D013778:Tetrazolium Salts; D013844:Thiazoles; D018698:Glutamic Acid; D016202:N-Methylaspartate; C022616:thiazolyl blue; D002118:Calcium; C476560:sabiporide