Cell cycle: how cyclin E got its groove back.
CDK1 has long been known to orchestrate the passage of mammalian cells into and through mitosis. Recent work revisits the idea that CDK1, in conjunction with cyclin E, participates in S-phase entry as well. The new results shed light on a recent cell-cycle mystery, and provide another dramatic example of apparent functional redundancy among cyclins and cyclin-dependent kinases.
Welcker
Markus
M
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Clurman
Bruce
B
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D019927:Cyclin E / Q000378:metabolism*; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D016196:S Phase / Q000502:physiology*; D015003:Yeasts
D019927:Cyclin E; D016203:CDC2 Protein Kinase; D051357:Cyclin-Dependent Kinase 2