Alterations in cell-mediated immune response in subacute sclerosing panencephalitis.
To investigate T cell responses in subacute sclerosing panencephalitis (SSPE), we analyzed proliferation and cytokine secretion of cells from 35 patients and 42 healthy controls (HC) in response to central nervous system (CNS) antigens. The proliferation in response to myelin basic protein (MBP), myelin oligodendrocyte-glycoprotein (MOG) and alphaB-crystallin did not differ between groups. There was a trend towards a decrease in IL-12 production in response to MBP and in vitro IL-12 secretion of SSPE patients to measles virus vaccine (MVV) was lower than controls. Proliferation, as well as IFN-gamma, IL-12 and IL-10 production in response to purified protein derivate (PPD) was impaired in SSPE patients. The results did not demonstrate any by-stander cellular response against myelin antigens, implicating that CNS is not a predominant target of an autoimmune response in SSPE. The recall responses were lower in SSPE as reported in measles before.
Yentür
Sibel P
SP
Department of Physiology, Istanbul Medical Faculty, Istanbul University, Turkey.
Gürses
Candan
C
Demirbilek
Veysi
V
Yilmaz
Gülden
G
Onal
Ayşe Emel
AE
Yapici
Zuhal
Z
Yalçinkaya
Cengiz
C
Cokar
Ozlem
O
Gökyiğit
Ayşen
A
Saruhan-Direskeneli
Güher
G
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D007381:Intermediate Filament Proteins / Q000276:immunology; D009000:Monocytes / Q000378:metabolism / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins / Q000276:immunology; D011494:Protein Kinases / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood / Q000276:immunology* / Q000473:pathology; D038203:alpha-Crystallin B Chain
C059215:CRYAB protein, human; D016207:Cytokines; D007381:Intermediate Filament Proteins; C571326:MOG protein, human; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D038203:alpha-Crystallin B Chain; D011494:Protein Kinases