Novel prenyltransferase enzymes as a tool for flavonoid prenylation.
The recent identification of genes encoding a novel family of soluble aromatic prenyltransferases from Streptomyces species and the structural characterization of one of these proteins are challenging discoveries in the biochemistry of natural compounds. In addition to their notable physiological role in the biosynthesis of aminocoumarin antibiotics, these enzymes represent an advanced tool for exploring novel isoprenoid substitutions in aromatic compounds and are expected to foster the emerging pharmacological applications of prenylated flavonoids.
Botta
Bruno
B
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, 00185 Roma, Italy. bruno.botta@uniroma1.it
Delle Monache
Giuliano
G
Menendez
Pilar
P
Boffi
Alberto
A
D004122:Dimethylallyltranstransferase / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry*; D017368:Protein Prenylation; D013302:Streptomyces / Q000201:enzymology*; D013379:Substrate Specificity
D005419:Flavonoids; D004122:Dimethylallyltranstransferase