[Arctic teleost fishes with canceled accelerated senescence program are a potential source of stress protectors and cancer drugs].
A new approach to the development of natural cancer drugs from hydrobionts selected for longevity and stress resistance is analyzed. The accelerated senescence program was successfully canceled in holarctic stickleback Gasterosteus aculeatus by crossing the marine and freshwater forms in ponds and selection of hybrids. Prolongation of fish life was accompanied by an increased production of the antistress exocrine secretion by the renal epithelium of male sticklebacks (glycoproteins, peptides, and mucoids), required for successful egg development. Trials of the biologic prepared from this secretion in salmons with epithelioma, guinea pigs with affected skin, and mice with transplantable tumors demonstrated a good therapeutic effect of the biologic.
Ziuganov
V V
VV
Popkovich
E G
EG
D019588:Aging, Premature / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism*; D008136:Longevity; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D020011:Protective Agents / Q000302:isolation & purification / Q000627:therapeutic use; D011506:Proteins / Q000302:isolation & purification / Q000627:therapeutic use; D023701:Smegmamorpha / Q000235:genetics / Q000378:metabolism*; D013312:Stress, Physiological / Q000188:drug therapy
D000970:Antineoplastic Agents; D020011:Protective Agents; D011506:Proteins