title: Modelling and simulation in the development and use of anti-cancer agents: an underused tool?
abstract: To help identify the role of modelling and simulation in the development of anti-cancer agents, their main advantages and the obstacles to their rational use, an expert meeting was organized by COST B15. This manuscript presents a synthesis of views expressed at that meeting and indicates future directions. The manuscript also shows some examples where modelling and simulation have proven to be of relevant value in the drug development process for anti-cancer agents.
authors.affiliation: Department for Modelling and Simulation, Grünenthal GmbH, P.O. Box 500444, 52088 Aachen, Germany.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Rombout
authors.forename: Leon
authors.initials: L
authors.lastname: Aarons
authors.forename: Mats
authors.initials: M
authors.lastname: Karlsson
authors.forename: Anthony
authors.initials: A
authors.lastname: Man
authors.forename: France
authors.initials: F
authors.lastname: Mentré
authors.forename: Peter
authors.initials: P
authors.lastname: Nygren
authors.forename: Amy
authors.initials: A
authors.lastname: Racine
authors.forename: Hans
authors.initials: H
authors.lastname: Schaefer
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Steimer
authors.forename: Iñaki
authors.initials: I
authors.lastname: Troconiz
authors.forename: Achiel
authors.initials: A
authors.lastname: van Peer
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000069287:Capecitabine; D002986:Clinical Trials as Topic; D003198:Computer Simulation; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077143:Docetaxel; D004334:Drug Administration Schedule; D015195:Drug Design; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008954:Models, Biological; D011358:Product Surveillance, Postmarketing; D011788:Quality of Life; D043823:Taxoids / Q000627:therapeutic use; D014747:Vinblastine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D003841:Deoxycytidine; D000077143:Docetaxel; C111217:vinflunine; D014747:Vinblastine; D000069287:Capecitabine; D005472:Fluorouracil