Mechanisms of regulation of erythropoiesis during experimental neuroses.
We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and alpha- and beta-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.
Skurikhin
E G
EG
Laboratory of Pathophysiology and Experimental Therapy, Group of Psychopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Dygai
A M
AM
Provalova
N V
NV
Minakova
M Yu
MY
Suslov
N I
NI
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000502:physiology; D003114:Colony-Forming Units Assay; D003220:Conflict, Psychological; D004087:Dihydroergotamine / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000502:physiology*; D004920:Erythropoiesis / Q000502:physiology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D006413:Hematopoietic System / Q000502:physiology; D009921:Metaproterenol / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D009497:Neurotic Disorders / Q000503:physiopathology*; D011433:Propranolol / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D012892:Sleep Deprivation / Q000503:physiopathology; D012895:Sleep, REM
D018759:Adrenergic Uptake Inhibitors; D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D018491:Dopamine Agonists; D005730:Ganglionic Blockers; D000644:Quaternary Ammonium Compounds; D011941:Receptors, Adrenergic; D004087:Dihydroergotamine; D009921:Metaproterenol; C040648:pentamine; D012110:Reserpine; D011433:Propranolol