title: Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas.
abstract: OBJECTIVE
  To determine whether there is an association between gene expression profile and looping extravascular matrix patterns in primary uveal melanomas.
  
  
  METHODS
  Laboratory investigation.
  
  
  METHODS
  Formalin-fixed, paraffin-embedded sections from 22 primary uveal melanomas that previously were analyzed by microarray gene expression profiling were stained for periodic acid-Schiff and scored in a masked fashion for the presence of looping extravascular matrix patterns.
  
  
  RESULTS
  A strong association was observed between looping patterns and the unfavorable class 2 molecular prognostic signature (P < .001).
  
  
  CONCLUSIONS
  Looping extravascular matrix patterns occur almost exclusively in class 2 uveal melanomas. This finding may provide new insights into the pathogenesis and management of uveal melanoma.
authors.affiliation: Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Onken
authors.forename: Amy Y
authors.initials: AY
authors.lastname: Lin
authors.forename: Lori A
authors.initials: LA
authors.lastname: Worley
authors.forename: Robert
authors.initials: R
authors.lastname: Folberg
authors.forename: J William
authors.initials: JW
authors.lastname: Harbour
mesh_terms: D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D008545:Melanoma / Q000098:blood supply*; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000473:pathology*; D020411:Oligonucleotide Array Sequence Analysis; D010503:Periodic Acid-Schiff Reaction; D014604:Uveal Neoplasms / Q000098:blood supply*
chemical_list: D009363:Neoplasm Proteins