Immunogenicity and safety of inactivated influenza virus vaccine in young children in 2003-2004.
This study assessed the safety and immunogenicity of a pediatric formulation of the 2003-2004 inactivated, trivalent, split virion influenza vaccine, administered in a 2-dose schedule in healthy children ages 6-36 months, of whom 94% had protective titers (> or =1/40) to at least 1 antigen. The 2003-2004 split virion influenza vaccine was safe and immunogenic in young children.
Mitchell
Douglas K
DK
Center for Pediatric Research, Eastern Virginia Medical School, Norfolk, 23510, USA. dkmitchel@chkd.com
Ruben
Frederick L
FL
Gravenstein
Stefan
S
D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control*; D016896:Treatment Outcome; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D014771:Virion / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated