What are SNPs and haplotypes and how will they help us manage the prevention of adult cancer?
Human genetic variation data are now publicly available on a large scale, from public and private discovery efforts. Datasets from the International Haplotype Map Consortium and Perlegen Sciences provide a level of knowledge about human genetic variation that is unprecedented. In combination with novel high-throughput genotyping technologies, these new resources will allow cancer prevention investigators to identify in a more precise way which genetic subsets of patients are likely to benefit most from chemoprevention and screening interventions.
Velasquez
Jonathan L
JL
Department of Medicine, Division of Hematology-Oncology, University of California, Irvine, 839 Medical Sciences Court, 2nd Floor, Sprague Hall--Lab 250, Irvine, CA 92697, USA.
Lipkin
Steven M
SM
D000328:Adult; D018890:Chemoprevention; D014644:Genetic Variation; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*