[Determinants of postprandial lipemia measured as diurnal triglyceride profile in non diabetic normolipidemic subjects].
OBJECTIVE
We decided to evaluate the clinical and biochemical predictors of postprandial lipemia, measured as daylong capillarly triglycerides (TGc) profiles, in normolipidemic non diabetic subjects.


METHODS
We studied 76 normolipidemic non diabetic subjects (45 premenopausal females). Accutrend was used to measure daylong TGc profiles during 3 days in 6 previously standardized points: fasting, pre and 3 h after dinner and lunch and at bedtime. The area under the curve of TGc (AUC-TGc) was determined as expression of postprandial lipemia.


RESULTS
Males showed significantly higher AUC-TGc (26.20 [11.00] vs 19.12 [6.57] in females; p < 0.001). Obese showed significantly higher values of AUC-TGc (27.87 [12.47] vs 20.05 [7.04]; p < 0.01). The AUC-TGc correlated with: age (r = 0.242; p < 0.05), body mass index (r = 0.312; p < 0.01), waist circumference (r = 0.394; p < 0.01), fasting plasma triglyceride (r = 0.634; p < 0.001), fasting insulinemia (r = 0.485; p < 0.001) and fasting HOMA (r = 0.484; p < 0.001). The multivariate analysis showed that HOMA (regression coefficient: 0.352; p = 0.02) and waist circumference (regression coefficient: 0.4; p = 0.05) were independent predictors of the AUC-TGc.


CONCLUSIONS
Independent determinants of postprandial lipemia were waist circumference and HOMA.
González
Cintia
C
Hospital Clínico Universitario de Valencia, Departamento de Medicina, Universidad de Valencia, Valencia, Spain.
Real
José T
JT
Bartual
Amadaro
A
Chaves
Felipe J
FJ
García-García
Ana B
AB
Blesa
Sebastián
S
Castro-Cabezas
Manuel
M
Ascaso
Juan F
JF
Carmena
Rafael
R
D000328:Adult; D019540:Area Under Curve; D001774:Blood Chemical Analysis; D015992:Body Mass Index; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism; D049629:Waist-Hip Ratio
D014280:Triglycerides