Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.
Chen
Kevin X
KX
Schering-Plough Research Institute, 2015 Galloping Hill Road, K-15-3/3545, Kenilworth, NJ 07033, USA. kevin.chen@spcorp.com
Njoroge
F George
FG
Vibulbhan
Bancha
B
Prongay
Andrew
A
Pichardo
John
J
Madison
Vincent
V
Buevich
Alexei
A
Chan
Tze-Ming
TM
D018360:Crystallography, X-Ray; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D011392:Proline / Q000737:chemistry*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D047028:Macrocyclic Compounds; D015842:Serine Proteinase Inhibitors; D011392:Proline; D019272:Leukocyte Elastase