title: All-phase MR angiography using independent component analysis of dynamic contrast enhanced MRI time series: phi-MRA.
abstract: Dynamic contrast enhanced magnetic resonance imaging (dynamic MRI) represents a MRI version of non-diffusible tracer methods, the main clinical use of which is the physiological construction of what is conventionally referred to as perfusion images. The raw data utilized for constructing MRI perfusion images are time series of pixel signal alterations associated with the passage of a gadolinium containing contrast agent. Such time series are highly compatible with independent component analysis (ICA), a novel statistical signal processing technique capable of effectively separating a single mixture of multiple signals into their original independent source signals (blind separation). Accordingly, we applied ICA to dynamic MRI time series. The technique was found to be powerful, allowing for hitherto unobtainable assessment of regional cerebral hemodynamics in vivo.
authors.affiliation: Center for Integrated Brain Science, Brain Research Institute, University of Niigata, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Matsuzawa
authors.forename: Hironaka
authors.initials: H
authors.lastname: Igarashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakayama
authors.forename: Ingrid L
authors.initials: IL
authors.lastname: Kwee
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002544:Cerebral Infarction / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA