Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.
Capecitabine is used to treat advanced breast and gastrointestinal malignancies. A single case of encephalopathy and three cases of peripheral neuropathy are the only neurotoxicities reported. The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.
Videnovic
A
A
Davee Department of Neurology and Neurological Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Semenov
I
I
Chua-Adajar
R
R
Baddi
L
L
Blumenthal
D T
DT
Beck
A C
AC
Simuni
T
T
Futterer
S
S
Gradishar
W
W
Tellez
C
C
Raizer
J J
JJ
D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D001943:Breast Neoplasms / Q000188:drug therapy; D000069287:Capecitabine; D002277:Carcinoma / Q000188:drug therapy; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000188:drug therapy; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D028761:Withholding Treatment
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil