An epidermal growth factor receptor intron 1 polymorphism in healthy women in Poland.
The frequency of CA allele combinations was assessed in healthy women from Poland and compared to previously published polymorphism data of individuals from Germany and a Caucasian reference group. There were close similarities between these three geographically and ethnically similar populations. By contrast, the distribution of these alleles in European and Asian (Japan) populations proved to be different. There might therefore be major ethnic differences in allelic frequencies of EGFR intron 1 polymorphism. Our results provide new data on EGFR microsatellite instability and may contribute to the understanding of EGFR gene expression regulation. The clinical relevance of these findings warrants further evaluation.
Bielawski
K P
KP
Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Germany. bielawsk@biotech.univ.gda.pl
Klos
P
P
Welnicka-Jaskiewicz
M
M
Tidow
M
M
Brandt
B
B
Falkiewicz
B
B
Zaczek
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D018900:Dinucleotide Repeats / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005858:Germany; D006801:Humans; D007438:Introns; D007564:Japan; D008875:Middle Aged; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
D066246:ErbB Receptors