title: [A tumor-like lymphocytis mastitis].
abstract: A 44-year-old woman presenting with an inflammatory and palpable firm breast lump underwent surgical excision. Intraoperative frozen section analysis showed an extensive lesion consisting of ducts with intraluminal "necrosis". In addition, a very dense stromal inflammation was observed around these ducts, suggesting an invasive ductal carcinoma with predominant intraductal proliferation. However, on paraffin sections, epithelial cells close to the lymphocytic infiltrate were rare, subatrophic, without any neoplastic feature. The density and architecture of the lymphocytic infiltrate mimicked a breast lymphoma. However, immunochemistry and molecular biology investigation favored the diagnosis of a tumor-like lymphocytic mastitis. Although extremely rare, this particular form of lymphocytic mastitis, a diagnostic pitfall particularly during peroperative examination, should be recognized by pathologists.
authors.affiliation: Service d'Anatomie et Cytologie Pathologiques du Pr Colette Taranger-Charpin, CHU Nord, Chemin des Bourelly, 13915 Marseille Cedex 20. sophie.giusiano@netcourrier.com
authors.forename: Sophie
authors.initials: S
authors.lastname: Giusiano
authors.forename: Lucile
authors.initials: L
authors.lastname: Andrac-Meyer
authors.forename: Séverine
authors.initials: S
authors.lastname: Meunier-Carpentier
authors.forename: Luc
authors.initials: L
authors.lastname: Xerri
authors.forename: L
authors.initials: L
authors.lastname: Boubli
authors.forename: Colette
authors.initials: C
authors.lastname: Taranger-Charpin
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007249:Inflammation; D008214:Lymphocytes / Q000473:pathology*; D008413:Mastitis / Q000473:pathology* / Q000601:surgery; D009336:Necrosis