Photoallergic contact sensitization to 6-methylcoumarin in poikiloderma of Civatte.
A 49-year-old woman presented with asymptomatic progressive erythema, hyperpigmentation, atrophy, and telangiectasia on her neck. The clinical appearance and histopathology of the skin lesion was consistent with poikiloderma of Civatte. Photopatch-testing with our standard photoallergens yielded a positive reaction to 6-methylcoumarin, which was found in the patient's perfume. This report describes the first case in which photoallergic contact sensitization to 6-methylcoumarin may play an important role in the pathogenesis of poikiloderma of Civatte.
Vachiramon
Vasanop
V
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Wattanakrai
Penpun
P
D003374:Coumarins / Q000009:adverse effects*; D017454:Dermatitis, Photoallergic / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010476:Perfume / Q000009:adverse effects*; D011038:Rothmund-Thomson Syndrome / Q000150:complications* / Q000473:pathology
D003374:Coumarins; D010476:Perfume; C018096:6-methylcoumarin