Psychopharmacology of the hallucinogenic sage Salvia divinorum.
At present, the Mexican mint Salvia divinorum is an unregulated hallucinogen. This has resulted in various on-line botanical companies advertising and selling S. divinorum as a legal alternative to other regulated plant hallucinogens. It is predictable that its misuse will increase rapidly. The active ingredient in S. divinorum is the neoclerodane diterpene, salvinorin A (1a), which has been shown to be a kappa agonist both in vitro and in vivo. This review will cover the current state of research into the psychopharmacology of S. divinorum.
Prisinzano
Thomas E
TE
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, S327 PHAR, MNPC, 115 S. Grand Ave., Iowa City, IW 52242, USA. thomas-prisinzano@uiowa.edu
D000818:Animals; D006213:Hallucinogens / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D017473:Receptors, Opioid, kappa / Q000819:agonists; D027544:Salvia / Q000009:adverse effects* / Q000737:chemistry / Q000633:toxicity
D006213:Hallucinogens; D017473:Receptors, Opioid, kappa