title: Cibenzoline induced Brugada ECG pattern.
abstract: We report a case of a 61-year-old female patient who presented with palpitations. The baseline electrocardiogram showed incomplete right bundle branch block with saddle back pattern of the ST segment in one precordial lead, but without any significant ST elevation. She was treated with oral cibenzoline. The subsequent ECG showed a coved Brugada ECG (type I) pattern, which resolved following the discontinuation of cibenzoline. An ajmaline test reproduced the coved type Brugada ECG pattern. Our case is the first report of oral cibenzoline therapy unmasking the diagnostic coved Brugada ECG pattern in a patient with a baseline normal ECG. Cibenzoline, a class I sodium channel blocker antiarrhythmic drug, should probably be avoided in the treatment of patients with Brugada syndrome.
authors.affiliation: Cardiovascular Research and Teaching Institute, Aalst Cardiovascular Center, OLV Hospital, Moorselbaan 164, 9300 Aalst, Belgium. andreasarkozy@yahoo.ca
authors.forename: Andrea
authors.initials: A
authors.lastname: Sarkozy
authors.forename: Axel
authors.initials: A
authors.lastname: Caenepeel
authors.forename: Peter
authors.initials: P
authors.lastname: Geelen
authors.forename: Peter
authors.initials: P
authors.lastname: Peytchev
authors.forename: Marc
authors.initials: M
authors.lastname: de Zutter
authors.forename: Pedro
authors.initials: P
authors.lastname: Brugada
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002037:Bundle-Branch Block / Q000139:chemically induced / Q000175:diagnosis*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D026941:Sodium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D026941:Sodium Channel Blockers; C032151:cifenline