Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice.
The anti-diabetic effect of Cinnamomi cassiae extract (Cinnamon bark: Lauraceae) in a type II diabetic animal model (C57BIKsj db/db) was studied. Cinnamon extract was administered at different dosages (50, 100, 150 and 200 mg/kg) for 6 weeks. It was found that blood glucose concentration is significantly decreased in a dose-dependent manner (P<0.001) with the most in the 200 mg/kg group compared with the control. In addition, serum insulin levels and HDL-cholesterol levels were significantly higher (P<0.01) and the concentration of triglyceride, total cholesterol and intestinal alpha-glycosidase activity were significantly lower after 6 weeks of the administration. These results suggest that cinnamon extract has a regulatory role in blood glucose level and lipids and it may also exert a blood glucose-suppressing effect by improving insulin sensitivity or slowing absorption of carbohydrates in the small intestine.
Kim
Sung Hee
SH
Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Hyun
Sun Hee
SH
Choung
Se Young
SY
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000502:physiology; D002935:Cinnamomum zeylanicum; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts