title: Extracavitary primary effusion lymphoma of the anorectum.
abstract: We report a case of an extracavitary primary effusion lymphoma occurring in the anorectum of a patient with advanced acquired immune deficiency syndrome. The morphology, null cell immunophenotype, and acquisition of plasma cell markers in this case are typical of the so-called solid variant of primary effusion lymphoma. Lymphoma cells in this case were shown to be co-infected with human herpesvirus-8 and Epstein-Barr virus. Following combination chemotherapy and highly active antiretroviral therapy, this patient has remained in clinical remission for > 3.5 years. The purpose of this report is to add another case to the emerging literature regarding the heterogeneous category of extraserous human herpesvirus-8-associated lymphomas.
authors.affiliation: Department of Pathology, Baystate Medical Center, Springfield, MA, USA.
authors.forename: Liron
authors.initials: L
authors.lastname: Pantanowitz
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wu
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Dezube
authors.forename: German
authors.initials: G
authors.lastname: Pihan
mesh_terms: D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000821:virology