title: Synthesis and biological evaluation of phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides.
abstract: The synthesis of carbocyclic 2'-oxa-3'-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Chiacchio
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannazzo
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.forename: Roberto
authors.initials: R
authors.lastname: Romeo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Romeo
authors.forename: Antonio
authors.initials: A
authors.lastname: Rescifina
authors.forename: Monica
authors.initials: M
authors.lastname: Saglimbeni
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D010758:Phosphorus / Q000737:chemistry*; D011684:Purine Nucleosides / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D001372:Aza Compounds; D011684:Purine Nucleosides; C468766:oxanine; D010758:Phosphorus