title: Topographic analysis of flash visual evoked potentials in dogs.
abstract: Visual evoked potentials by flash stimulation (flash VEP) were analyzed in dogs using a topographic method. The flash VEP consisted of 3 positive (P1, P2 and P3) and 2 negative (N1 and N2) components by 150 msec after the flash stimuli. On the topographic mappings, a negative response area was observed in the frontal region of the scalp in the stimulated site followed by the shifting of the area to the contralateral frontal region and occipital region, during the first 100 msec. The negative response area in the frontal region in the stimulated site, contralateral frontal and temporal region, and occipital region were corresponded to N1, P2, and N2 on the flash VEP, respectively, according to their latencies. In the dogs with experimentally impaired the right lateral geniculate body, the latency of P2 was prolonged, and N2 and P3 were disappeared after the left eye stimulation. On the topographic mapping, only the early negative response area was detected on the stimulated site of the frontal region of the brain. Therefore, it is concluded that P1 and N1, P2, and N2 are referred to the retinal potentials, the potentials from the retina to the brainstem included the lateral geniculate body, and those from the brainstem to the visual cortex, respectively.
authors.affiliation: Medicinal Safety Research Laboratories, Sankyo Co., Ltd., Shizuoka, Japan.
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Kimotsuki
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Yasuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tamahara
authors.forename: Naoaki
authors.initials: N
authors.lastname: Matsuki
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D001931:Brain Mapping; D004285:Dogs / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D010775:Photic Stimulation; D014795:Visual Pathways / Q000502:physiology*