title: Incidence of neonatal infection in newborn infants with a maternal history of premature rupture of membranes (PROM) for 18 hours or longer by using Phramongkutklao Hospital Clinical Practice Guideline (CPG).
abstract: BACKGROUND
  Phramongkutklao CPG was developed for detecting infants with maternal PROM > or = 18 hours who had a high risk of infection.
  
  
  OBJECTIVE
  To determine efficacy of the CPG, and risk factors of infection.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Eligible infants were categorized into group I (symptomatic), group II (chorioamnionitis) or group III (asymptomatic). Infants in group I, II and those in group III who had scores > or = 3 were treated with antibiotics. Infants were followed-up until 28 days of age.
  
  
  RESULTS
  104 infants were recruited into the present study. 29 of 104 (27.88%) infants had infection. Risk factors were Apgar scores < or = 5, PROM > 72 hours, gestational age < 34 weeks, and low birth weight. The success rate of using CPG was 98.08% and antibiotic use was reduced by 53.08%.
  
  
  CONCLUSIONS
  Phramongkutklao CPG on PROM is safe and cost saving. All risk factors should be included in the guideline.
authors.affiliation: Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand.
authors.forename: Woranart
authors.initials: W
authors.lastname: Ratanakorn
authors.forename: Witsanuchai
authors.initials: W
authors.lastname: Srijariya
authors.forename: Sangkae
authors.initials: S
authors.lastname: Chamnanvanakij
authors.forename: Preyapan
authors.initials: P
authors.lastname: Saengaroon
mesh_terms: D000328:Adult; D002821:Chorioamnionitis / Q000453:epidemiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D013997:Time Factors