title: Trichodermamide A and aspergillazine A, two cytotoxic modified dipeptides from a marine-derived fungus Spicaria elegans.
abstract: Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
authors.affiliation: Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Qian-Qun
authors.initials: QQ
authors.lastname: Gu
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Zhu
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Cui
authors.forename: Guo-Tao
authors.initials: GT
authors.lastname: Fan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D014871:Water Microbiology
chemical_list: D000970:Antineoplastic Agents; D004151:Dipeptides; C505497:aspergillazine A; C476747:trichodermamide A