No association between attention-deficit hyperactivity disorder and catechol-O-methyltransferase gene in Chinese.
Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder(ADHD). Since catechel-O-methyltransferase (COMT) is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems,it is possible that COMT may play a role in ADHD. To test this hypothesis, we used two family-based analyses,the transmission disequilibrium test (TDT) and the haplotype-based haplotype relative risk (HHRR), to examine the possible association between COMT gene and DSM-IV-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT (chi2 = 1.03, df=1, P > 0.05) and HHRR (chi2 = 1.08, df = 1, P > 0.05) analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Our data suggested that there was no association between ADHD and the COMT gene in the Chinese population.
Jiang
San-Duo
SD
Department of Genetics, Shanghai Mental Health Center, Shanghai 200030, China. jiangsanduo@163.com
Wu
Xiao-Dong
XD
Zhang
Ye
Y
Tang
Guo-Mei
GM
Qian
Yi-Ping
YP
Wang
Dong-Xiang
DX
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male
D002394:Catechol O-Methyltransferase