A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses.
Graft-versus-leukemia (GVL) response after allogeneic bone marrow transplantation (BMT) represents one of the most potent forms of immunotherapy against malignant diseases. Antigen-presenting cells (APCs) are crucial for the induction of graft-versus-host disease (GVHD), the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.
Reddy
Pavan
P
Department of Internal Medicine, University of Michigan Cancer Center, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0942, USA. reddypr@umich.edu
Maeda
Yoshinobu
Y
Liu
Chen
C
Krijanovski
Oleg I
OI
Korngold
Robert
R
Ferrara
James L M
JL
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D016026:Bone Marrow Transplantation; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control; D020544:Graft vs Leukemia Effect / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology* / Q000378:metabolism; D007942:Leukemia, Experimental / Q000276:immunology / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018183:Transplantation Chimera; D014184:Transplantation, Homologous
D007519:Isoantigens