title: Surveillance of nosocomial infections in paediatric recipients of bone marrow or peripheral blood stem cell transplantation during neutropenia, compared with adult recipients.
abstract: The aim of this prospective study was to analyse the incidence of nosocomial infections (NIs) during neutropenia after haematopoietic stem cell transplantation (HSCT) in paediatric and adult patients. Diagnosis of NI followed the modified surveillance protocol of the German National Reference Centre for Surveillance of NIs. During the 24-month study period, 38 and 39 transplantations were performed in paediatric and adult patients, respectively. Eighty percent and 92% of the paediatric and adult patients, respectively, underwent allogenic HSCT. In total, 1156 neutropenic days were documented. The incidence of NI during neutropenia in all recorded cases was 38.9 NI per 1000 days, without significant difference between the groups. No difference was found in the incidence rates of pneumonia, while there was a trend towards a higher incidence of bloodstream infection in adult patients. Significantly more episodes of fever of unknown origin were found in paediatric than adult patients. Pathogens were isolated in 19 of 45 cases of NI. Of the clinically documented infections, Gram-positive organisms were isolated in 79%, Gram-negative organisms were isolated in 16% and fungi were isolated in 5%. Surveillance of NI is an effective instrument to control the quality of health care. It should focus on device-associated infections or specific high-risk targets such as nosocomial pneumonia.
authors.affiliation: Department of Paediatric Oncology, Haematology and Immunology, University Hospital of Düsseldorf, Düsseldorf, Germany. laws@med.uni-dusseldorf.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Laws
authors.forename: G
authors.initials: G
authors.lastname: Kobbe
authors.forename: D
authors.initials: D
authors.lastname: Dilloo
authors.forename: M
authors.initials: M
authors.lastname: Dettenkofer
authors.forename: R
authors.initials: R
authors.lastname: Meisel
authors.forename: R
authors.initials: R
authors.lastname: Geisel
authors.forename: R
authors.initials: R
authors.lastname: Haas
authors.forename: U
authors.initials: U
authors.lastname: Göbel
authors.forename: R
authors.initials: R
authors.lastname: Schulze-Röbbecke
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011159:Population Surveillance; D011446:Prospective Studies