title: [Gastrointestinal stromal tumor (GIST) with jejunum localisation, unusual source of digestive bleeding. Considerations about two cases].
abstract: Gastrointestinal stromal tumors are those gastrointestinal tumors , which expression antigens for CD 117 and CD 34. GIST arise from c - kit gene mutation through inadequate function of KIT enzyme (thyroxine kinase). However, the name is gastrointestinal stromal tumor, their localisation maybe under esophagus, stomach, duodenum, small bowel or colorectal.. CT scanning shows tumoral mass with nonspecific affiliation thanks to this development extraluminal and exophytic. Digestive hemorrhage, through GIST with small bowel localisation was called "obscure" because of impossibility to detect preoperative a bleeding source. We present, two cases of hemorrhage through GIST with jejunal localisation, male 70 years old with 10 cm tumor, discovered through CT scanning such as tumoral mass in left hypochondrium and female 55 years old, with 3 m tumor, discovered through emergency laparotomy for severe digestive bleeding. Also, it is discussed the possibility of intraoperative diagnosis, criterion to appreciate benign and malign features of the tumors and to determine their mitotic index for the supervision of these two cases.
authors.affiliation: Clinica Chirurgie II, Spitalul Clinic Judetean de Urgenţă B-dul 1 Mai, Nr. 60, Craiova, Dolj. pasmar@mail.com
authors.forename: M
authors.initials: M
authors.lastname: Paşalega
authors.forename: C
authors.initials: C
authors.lastname: Meşină
authors.forename: D
authors.initials: D
authors.lastname: Vîlcea
authors.forename: Mihaela
authors.initials: M
authors.lastname: Cheie
authors.forename: I
authors.initials: I
authors.lastname: Vasile
mesh_terms: D000368:Aged; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007580:Jejunal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013974:Thyroxine; D016896:Treatment Outcome
chemical_list: D013974:Thyroxine