title: The combination of shared family environment and individual-specific developmental deviance as a cause for treated psychiatric morbidity in children.
abstract: OBJECTIVE
  There is an incomplete understanding of why some children growing up in the same family are in need of treatment for psychiatric morbidity whilst their siblings are not. The present paper examined the possible role of individual-specific developmental risk factors.
  
  
  METHODS
  Three case-control analyses were conducted: i) 80 children referred to the Community Mental Health Centre (cases) and 320 population controls, ii) 68 healthy siblings of cases and 272 population controls, and iii) 80 children and 68 healthy siblings. Measures of development and psychosocial circumstances were obtained from routine, longitudinal, standardized child medical records.
  
  
  RESULTS
  Given shared family environments, additional presence of delays in speech and motor development contributed most to differential sibling mental health outcomes. In addition, cases displayed both earlier expression and more severe levels of developmental behavioural deviance than their healthy siblings, who in turn had higher levels of behavioural deviance than population controls.
  
  
  CONCLUSIONS
  In siblings sharing a familial risk environment, development of psychiatric morbidity may be canalized through additional individual-specific developmental exposures.
authors.affiliation: Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Gunther
authors.forename: M
authors.initials: M
authors.lastname: Drukker
authors.forename: F
authors.initials: F
authors.lastname: Feron
authors.forename: A
authors.initials: A
authors.lastname: Korebrits
authors.forename: J
authors.initials: J
authors.lastname: van Os
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D004777:Environment; D005195:Family Relations; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology*; D008603:Mental Health; D019957:Motor Skills Disorders; D012307:Risk Factors; D035781:Siblings; D013064:Speech Disorders