title: [Methotrexate for the treatment of patients with chronic cutaneous sarcoidosis: 4 cases].
abstract: BACKGROUND
  Pathogenesis of sarcoidosis remains partially unknown. Cutaneous lesions are frequent (20 to 35% of cases). Their clinical features and follow-up data are highly variable. Numerous treatments have been proposed. The clinical features and follow up data of four patients with chronic cutaneous sarcoidosis treated with methotrexate are reported.
  
  
  METHODS
  Mean age of patients (3 female, 1 male) was 40 years old (34-49 years). One patient presented with a lupus pernio, two patients with papules and nodules, and the last with an annular lesion of the face. All patients had been previously treated with topical corticosteroids and/or hydroxychloroquine without any success. Patients were treated with methotrexate at doses ranging from 12.5 mg to 30 mg per week for at least 6 months. Complete remission of cutaneous lesions was observed in 3 of 4 patients after a mean treatment duration of 29 months (16 to 36). Methotrexate side effects were observed in one patient (elevated liver enzymes) leading to methotrexate discontinuation.
  
  
  CONCLUSIONS
  Methotrexate seems to be an effective treatment of cutaneous sarcoidosis. It should be used namely in patients who failed to respond to previous treatments with topical corticosteroids or antimalarial drugs.
authors.affiliation: Clinique Dermatologique, CHU de Rouen.
authors.forename: A
authors.initials: A
authors.lastname: Gary
authors.forename: A-B
authors.initials: AB
authors.lastname: Modeste
authors.forename: C
authors.initials: C
authors.lastname: Richard
authors.forename: C
authors.initials: C
authors.lastname: Jubert
authors.forename: F
authors.initials: F
authors.lastname: Majour
authors.forename: G
authors.initials: G
authors.lastname: Nouvet
authors.forename: B
authors.initials: B
authors.lastname: Remond
authors.forename: P
authors.initials: P
authors.lastname: Joly
mesh_terms: D000328:Adult; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D012507:Sarcoidosis / Q000188:drug therapy* / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate