Telling the liver (not) to make bile acids: a new voice from the gut?
The maintenance of adequate amounts of bile acids in the liver, biliary tract, and intestine requires a finely tuned control of their synthesis. A paper in this issue of Cell Metabolism by Inagaki et al. (2005) indicates that sensing of the levels of bile acids in the intestine may trigger the secretion of a hormone which regulates bile acid production in the liver.
Angelin
Bo
B
Department of Endocrinology, Metabolism & Diabetes, Karolinska Insitutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
D001647:Bile Acids and Salts / Q000096:biosynthesis* / Q000378:metabolism; D002790:Cholesterol 7-alpha-Hydroxylase / Q000096:biosynthesis; D004764:Enterohepatic Circulation; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000378:metabolism; D015398:Signal Transduction
D001647:Bile Acids and Salts; C108526:fibroblast growth factor 15, mouse; D005346:Fibroblast Growth Factors; D002790:Cholesterol 7-alpha-Hydroxylase; C502772:Cyp7a1 protein, mouse; D051499:Receptor, Fibroblast Growth Factor, Type 4