title: Effect of GB virus C viremia on HIV acquisition and HIV set-point.
abstract: We performed both a case-control study and a cohort study to determine whether GB virus C (GBV-C) viremia prevents the acquisition of HIV infection or alters the HIV set-point after infection. The prevalence of GBV-C viremia in HIV-uninfected individuals who did and did not acquire HIV were similar (odds ratio 1.32; 95% confidence interval 0.6-2.6). Pre-existing GBV-C viremia at the time of HIV acquisition was also not associated with lower plasma HIV-RNA levels.
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Bisson
authors.forename: Brian L
authors.initials: BL
authors.lastname: Strom
authors.forename: Robert
authors.initials: R
authors.lastname: Gross
authors.forename: Drew
authors.initials: D
authors.lastname: Weissman
authors.forename: Donna
authors.initials: D
authors.lastname: Klinzman
authors.forename: Wei-Ting
authors.initials: WT
authors.lastname: Hwang
authors.forename: Jay R
authors.initials: JR
authors.lastname: Kostman
authors.forename: David
authors.initials: D
authors.lastname: Metzger
authors.forename: Jack T
authors.initials: JT
authors.lastname: Stapleton
authors.forename: Ian
authors.initials: I
authors.lastname: Frank
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications / Q000821:virology*; D029407:GB virus C; D006678:HIV / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000821:virology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D014766:Viremia / Q000150:complications / Q000821:virology*
chemical_list: D012367:RNA, Viral