title: Sonohistology for the computerized differentiation of parotid gland tumors.
abstract: A system for the computerized differentiation of parotid gland tumors is proposed. The parotid gland is the largest of the salivary glands. It is found in the subcutaneous tissue of the face, overlying the mandibular ramus and anterior and inferior to the external ear. The classification system is based on a multifeature tissue characterization approach, using fuzzy inference systems as higher-order classifiers. Baseband ultrasonic echo data were acquired during conventional ultrasound imaging examinations using standard ultrasound equipment. Several tissue-describing parameters were calculated within numerous small regions of interest to evaluate spectral and textural tissue properties. The parameters were processed by an adaptive network-based fuzzy inference system, using the results of conventional histology after parotidectomy as the "gold standard." The results of the classification are presented as a numerical score indicating the probability of a certain tumor or alteration for each parotid gland. The score can be presented to the physician during examination of the patient to improve the differentiation between various types of parotid gland tumors. The system was evaluated on n = 23 cases of patients undergoing radical parotidectomy. The receiver operating characteristic curve area is A(ROC) = 0.95 +/- 0.07 when using fourfold cross-validation over cases and differentiating between various benign parotid gland tumors and monomorphic adenoma.
authors.affiliation: Institute of High-Frequency Engineering, Ruhr-University Bochum, Bochum, Germany. Ulrich@Scheipers.org
authors.forename: Ulrich
authors.initials: U
authors.lastname: Scheipers
authors.forename: Stefan
authors.initials: S
authors.lastname: Siebers
authors.forename: Frank
authors.initials: F
authors.lastname: Gottwald
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ashfaq
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bozzato
authors.forename: Johannes
authors.initials: J
authors.lastname: Zenk
authors.forename: Heinrich
authors.initials: H
authors.lastname: Iro
authors.forename: Helmut
authors.initials: H
authors.lastname: Ermert
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008949:Adenoma, Pleomorphic / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003560:Cysts / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D010306:Parotid Gland / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010307:Parotid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011336:Probability; D012372:ROC Curve; D012680:Sensitivity and Specificity; D014463:Ultrasonography