Attenuation of sensory and affective responses to heat pain: evidence for contralateral mechanisms.
Attenuation of responses to repeated sensory events has been thoroughly studied in many modalities; however, attenuation of pain perception has not yet benefitted from such extensive investigation. Described here are two psychophysical studies that examined the effects of repeated exposure to thermal stimuli, assessing potential attenuation of the perception of pain and its possible spatial specificity. Twenty-two subjects were presented thermal stimuli to the volar surface of the right and left forearms. Twelve subjects in study 1 received the same stimuli and conditions on each of five daily experimental sessions, whereas 10 subjects in study 2 received thermal stimuli, which were restricted to one side for four daily sessions and then applied to the other side on the fifth session. Ratings of warmth intensity, pain intensity, and pain unpleasantness were recorded while the subjects performed a thermal sensory discrimination task. Results of study 1 demonstrate that repeated stimulation with noxious heat can lead to long-term attenuation of pain perception; results of study 2 extend these findings of attenuation to both pain intensity and unpleasantness and show that this effect is highly specific to the exposed body side for both aspects of the pain experience. We suggest that the functional plasticity underlying this attenuation effect lies in brain areas with a strong contralateral pattern of pain-related activation.
Gallez
Ariane
A
Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montreal, Quebec, Canada.
Albanese
Marie-Claire
MC
Rainville
Pierre
P
Duncan
Gary H
GH
D000222:Adaptation, Physiological; D000328:Adult; D000339:Affect; D001921:Brain / Q000503:physiopathology; D019317:Evidence-Based Medicine / Q000379:methods; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009473:Neuronal Plasticity; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D017288:Pain Threshold / Q000502:physiology*; D020886:Somatosensory Disorders / Q000209:etiology / Q000503:physiopathology*