title: [Splenectomy in haematologic diseases. Clinical indications and surgical technique].
abstract: After the introduction of corticosteroids fifty years ago the indications for splenectomy in benign haematological diseases became more controversial, also due to the morbidity and mortality associated at that time with open splenectomy. The advent of minimally invasive techniques has provided safe procedures for removal of the spleen in cases of benign as well as malignant haematological disease. Laparoscopic splenectomy has been performed for spleens of normal size or larger size or weight. In this study the indications in haematological diseases and the results after splenectomy are analysed. From June 1998 to December 2004 107 patients with benign or malignant haematological disease were referred to our unit for splenectomy. Splenomegaly was defined as a spleen diameter > 15 cm and weight > 400 g and was present in 53% of cases in this series. Open splenectomy was carried out in 30 cases and laparoscopic splenectomy in 77. Operating time, blood loss, conversion rate, need for transfusion, complications, length of hospital stay and operative morbidity were analysed for both open and laparoscopic procedures. In the laparoscopic splenectomy group the outcomes after removal of spleens < 15 cm and > 15 cm were compared. Clinical results after splenectomy in haemolytic anaemia and idiopathic thrombocytopenic purpura are reported. In the open splenectomy group the spleens were larger and heavier, hence the operating time was greater than in the laparoscopic splenectomy group. The mean age of patients in the open group was 65 years as against 43 years in the laparoscopic group. Morbidity was 23% in the open group and 10% in the laparoscopic group. Mortality was nil in both groups. The overall conversion rate in the laparoscopic group was 2.6% owing to extensive adhesions and bleeding in 2 large spleens measuring > 27 cm and weighing > 2 kg (conversion rate for larger spleens: 6.2%). Spleens > 15 cm were associated with greater blood loss (p < 0.01), longer operating times and a longer hospital stay. No cases of overwhelming post-splenectomy infection were registered in either group. The healing rate for idiopathic thrombocytopenic purpura after splenectomy was 87%, while for haemolytic anaemia it was 100%. In this study splenomegaly was associated with malignant haematological disease occurring in patients aged 65 on average in whom an open splenectomy was generally carried out. Benign diseases occurred in patients aged 43 on average in whom laparoscopic splenectomy was the preferred procedure. Conversion rate, morbidity and length of hospital stay were comparable with those of other series. Laparoscopic splenectomy can be considered the gold standard procedure for benign disease in young patients and also as a safe procedure in selected cases of malignant haematological disease.
authors.affiliation: Divisione di Chirurgia Generale e d'Urgenza, Ospedale Niguarda Ca' Granda - Milano.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pugliese
authors.forename: Dario
authors.initials: D
authors.lastname: Maggioni
authors.forename: Ildo
authors.initials: I
authors.lastname: Scandroglio
authors.forename: Fabio
authors.initials: F
authors.lastname: Sansonna
authors.forename: Giovanni
authors.initials: G
authors.lastname: Grilloa
authors.forename: Stefano
authors.initials: S
authors.lastname: Di Lernia
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Ferrari
authors.forename: Marco
authors.initials: M
authors.lastname: Boniardi
authors.forename: Andrea
authors.initials: A
authors.lastname: Costanzi
authors.forename: Carmelo
authors.initials: C
authors.lastname: Magistro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006402:Hematologic Diseases / Q000150:complications / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013156:Splenectomy / Q000379:methods; D013163:Splenomegaly / Q000209:etiology / Q000601:surgery; D016896:Treatment Outcome