[Course and prognosis of basaloid squamous cell carcinoma: case-control study of 49 patients].
BACKGROUND
The course and prognosis of basaloid squamous cell carcinoma (BSCC) are not well known.


OBJECTIVE
To study the course and prognosis in a population of BSCC patients.


METHODS
We analyzed a retrospective cohort of 49 patients with BSCC in comparison with a cross-matched population of 49 patients treated for well- to moderately differentiated squamous cell carcinoma (SCC).


RESULTS
The statistical analysis showed that survival in BSCC group was lower than in the SCC group. Local recurrence in the BSCC group was not higher than in the SCC group, but mortality by distant metastasis was six times higher than in the SCC population.


CONCLUSIONS
We consider BSCC patients as a high-risk population and we complete diagnosis explorations including a FDG-PET before curative treatment. We also recommend post-operative or exclusive radiotherapy which may be associated with concomitant chemotherapy.
Soriano
E
E
Service d'ORL, Hôpital Michallon, CHU BP 217, 38043 Grenoble cedex.
Righini
Ch
Ch
Faure
Cl
C
Lantuejoul
S
S
Colonna
M
M
Bolla
M
M
Brambilla
E
E
Reyt
E
E
D002281:Carcinoma, Basosquamous / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis