Antagonistic combinations of occupational carcinogens.
Several epidemiological and experimental studies demonstrate that combinations of carcinogens may interact in a synergistic way. This has prompted speculations that modulating interactions of individual chemical carcinogens are synergistic as a rule. However, various combinations of chemical carcinogens have been described which interact not even additively but in an antagonistic way. The aim of this review is to collect information of antagonistic interactions of occupational carcinogens obtained by epidemiologic and animal studies. In addition, appropriate in vitro studies with the genotoxic endpoints DNA-adducts and micronuclei are included. The toxicological mechanisms of antagonistic interactions, although speculative in some cases, are discussed.
Ruediger
Hugo W
HW
Division of Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. hugo.ruediger@meduniwien.ac.at
D016588:Anticarcinogenic Agents; D001151:Arsenic / Q000493:pharmacokinetics; D002273:Carcinogens / Q000493:pharmacokinetics*; D006801:Humans; D008748:Methylcholanthrene / Q000493:pharmacokinetics; D016273:Occupational Exposure; D012907:Smoking; D014481:United States
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D008748:Methylcholanthrene; D001151:Arsenic