The marriage of glucose and blood vessels: it isn't all that sweet.
The secondary complications of diabetes are the major factors limiting quality of life and longevity in diabetic patients. Among these complications, cardiovascular disease is the major cause of morbidity and mortality. Based on a recent paper by Vikramadithyan et al. (2005), this preview addresses the role of aldose reductase as a contributor to the pathogenesis of diabetic macrovascular disease.
Xiong
Wen-Cheng
WC
Institute of Molecular Medicine & Genomics, Medical College of Georgia, Augusta, Georgia 30912, USA.
Stern
David M
DM
D000449:Aldehyde Reductase / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001808:Blood Vessels / Q000201:enzymology*; D048909:Diabetes Complications / Q000201:enzymology* / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D051379:Mice; D014652:Vascular Diseases / Q000150:complications* / Q000201:enzymology / Q000378:metabolism*
D000449:Aldehyde Reductase; D005947:Glucose