Bax and Bcl-XL apoptosis protein mRNA in rat brain stem and cortex during ontogeny.
Bax mRNA level in fetal rat brain stem increases by day 40 of life and then decreases, while level of Bcl-XL mRNA reaches the adult value over one month. Bax mRNA level in the cerebral cortex decreases from day 8 to day 90 of life, while Bcl-XL mRNA level does not change. Judging from Bcl-XL/Bax mRNA ratio, cortical cells exhibit higher readiness to apoptosis than brain stem cells.
Bannova
A V
AV
Laboratory of Genetic Base of Neuroendocrine Regulation, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Moscow. anitik@bionet.nsc.ru
Men'shanov
P N
PN
Il'inykh
F A
FA
Kalinina
T S
TS
Dygalo
N N
NN
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001933:Brain Stem / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005333:Fetus; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein / Q000235:genetics*; D051020:bcl-X Protein / Q000235:genetics*
D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein