title: Antimicrobial resistance and plasmid profiles of urinary Escherichia coli isolates from Jordanian patients.
abstract: We investigated antimicrobial resistance patterns and plasmid profiles of uropathogenic Escherichia coli isolates from inpatients and outpatients at Jordan University Hospital in 2000 and 2001. E. coli accounted for 32.4% and 37.4% of all isolates respectively. The lowest susceptibility was for ampicillin (11%), cotrimoxazole (23%) and tetracycline (26%). The relative incidence of resistant isolates of E. coli to nalidixic acid, gentamicin, norfloxacin, cefuroxime and nitrofurantoin was significantly greater for inpatients than for outpatients (P< 0.05). A large, transferable R-plasmid of 28 kb was found in most E. coli isolates (67%) that were resistant to at least ampicillin, cotrimoxazole and tetracycline. This R-plasmid reservoir may contribute to the spread of multiple antibiotic resistance in our Region.
authors.affiliation: Department of Pathology and Microbiology, Faculty of Medicine, University of Jordan, Amman, Jordan.
authors.forename: A A
authors.initials: AA
authors.lastname: Shehabi
authors.forename: A M
authors.initials: AM
authors.lastname: Mahafzah
authors.forename: K Z
authors.initials: KZ
authors.lastname: Al-Khalili
mesh_terms: D017714:Community-Acquired Infections / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D011307:Drug Prescriptions; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004363:Drug Utilization; D004926:Escherichia coli / Q000235:genetics*; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology* / Q000652:urine; D005144:F Factor / Q000235:genetics; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007597:Jordan; D008297:Male; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D010641:Phenotype; D011159:Population Surveillance; D015995:Prevalence; D011446:Prospective Studies; D011815:R Factors / Q000235:genetics*; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology* / Q000652:urine
chemical_list: D004269:DNA, Bacterial