title: K65R and Y181C are less prevalent in HAART-experienced HIV-1 subtype A patients.
abstract: The vast majority of HIV-1 infections globally are caused by subtype A or C, although little is known about their drug resistance profiles. We found that HAART-experienced patients infected with subtype A had a lower prevalence of K65R and Y181C than those with subtypes B or C, despite similar exposure to antiretroviral agents that select for these mutations. If confirmed, this information may be important in the planning of antiretroviral regimens in patients infected with HIV-1 subtype A.
authors.affiliation: Department of Infection, Guy's and St Thomas' NHS Foundation Trust (GSTT), London, UK.
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Gupta
authors.forename: Ian L
authors.initials: IL
authors.lastname: Chrystie
authors.forename: Siobhan
authors.initials: S
authors.lastname: O'Shea
authors.forename: Jane E
authors.initials: JE
authors.lastname: Mullen
authors.forename: Ranjababu
authors.initials: R
authors.lastname: Kulasegaram
authors.forename: Cheuk Y W
authors.initials: CY
authors.lastname: Tong
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D024921:Drug Resistance, Multiple, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D012189:Retrospective Studies