Acute suicidal intoxication with tacrolimus in a kidney transplant patient.
A case of a 23-year-old female, after renal transplant, who had tried to commit suicide with 100 mg of Prograf was described. In the presented case despite the relatively high tacrolimus blood concentration level (>30 microg/l) only severe 5-hour lasting headache and short-term mild hyperglycaemia (7.22 mmol/l), hyperkalemia (5.4 mmol/l) and considerable leukocytosis (19.52 x 10(3)) were observed. In this case there was mild clinical course of intoxication despite tacrolimus high blood concentration. It could not be excluded that early administration of gastric lavage and activated carbon was partly responsible for mild course of poisoning.
Sein Anand
Jacek
J
1st Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk ul. Debinki 7, 80-211 Gdańsk, Poland. jsanand@amedec.amg.gda.pl
Chodorowski
Zygmunt
Z
Kujawska
Hanna
H
D000208:Acute Disease; D000328:Adult; D002606:Charcoal / Q000627:therapeutic use; D003863:Depression / Q000209:etiology; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000506:poisoning*; D016030:Kidney Transplantation / Q000523:psychology; D011041:Poisoning / Q000150:complications; D013406:Suicide, Attempted / Q000523:psychology; D016559:Tacrolimus / Q000506:poisoning*; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D002606:Charcoal; D016559:Tacrolimus