title: Experimental evaluation of Pentas lanceolata flowers for wound healing activity in rats.
abstract: The ethanolic extract of the flowers of Pentas lanceolata given by oral route to rats at dose of 150 mg kg(-1) day(-1) for 10 days, was studied for its effect on wound healing, using excision wound mode. Significant increase in granulation tissue weight, tensile strength, hydroxyproline and glycosaminoglycan content was observed. Moderate increase in protein content was seen. There was significant reduction in the wound area measurement of the test group as compared to that of controls. The efficacious prohealing action may be due to increased collagen deposition as well as better alignment and maturation.
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal Pin 576104, Karnataka, India. shivnayak25@yahoo.co.in
authors.forename: B S
authors.initials: BS
authors.lastname: Nayak
authors.forename: B
authors.initials: B
authors.lastname: Vinutha
authors.forename: B
authors.initials: B
authors.lastname: Geetha
authors.forename: B
authors.initials: B
authors.lastname: Sudha
mesh_terms: D000284:Administration, Oral; D000818:Animals; D035264:Flowers; D006097:Granulation Tissue / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019666:Rubiaceae; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts