[Association of angiotensin I converting enzyme 2 gene polymorphism with essential hypertension in Chinese].
OBJECTIVE
To identify the genetic variants of angiotensin I converting enzyme 2 (ACE2) gene in a Chinese population and to determine whether the ACE2 gene polymorphisms are associated with essential hypertension (EH).


METHODS
Seven hundred and forty-five patients with EH and 362 normal blood pressure controls were included in the study to assess the contribution of polymorphism of ACE2 gene. Direct DNA sequencing was performed to detect the single nucleotide polymorphisms (SNPs) in 20 subjects who were randomly selected from the EH patients.


RESULTS
One SNP named G8790A located in the 4th base of the third intron was found in the 20 patients. The genotyping data indicate that the A allele frequency in male EH patients complicated with cardiac incompetence(55%) is significantly different from that in the control group(43.3%)(P<0.01). The A allele frequency in female patients with cardiac incompetence (56.1%) is higher than that in the controls (50.5%), but the difference does not reach statistical significance.


CONCLUSIONS
The G8790A polymorphism may be related to the essential hypertension with cardiac incompetence in Chinese population. Additional investigation will be need to confirm the association.
Liu
Tong-bao
TB
Department of Cardiology, Shandong Provincial Hospital, Jinan, Shandong, PR China. liutongbao@medmail.com.cn
Shang
Hui-ping
HP
Zhang
Kui-xing
KX
Chen
Liang-hua
LH
Zhu
Xing-lei
XL
Zhang
Yi
Y
Zhu
Ding-liang
DL
Huang
Wei
W
D000368:Aged; D000085962:Angiotensin-Converting Enzyme 2; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2