title: Factors influencing low-molecular-weight solute clearance during hemodialysis.
abstract: The relationship between delivered urea Kt/V and survival has raised concerns in recent outcome trials in chronic dialysis patients. Nevertheless, measurement of delivered small solute clearance remains the most common approach to quantify therapy. The purpose of this review is to provide an overview of the numerous factors influencing small solute clearance during hemodialysis. Although the focus of the review is on the manner in which dialyzer characteristics influence small solute clearances, factors related to other aspects of the extracorporeal circuit and to the patient will also be discussed.
authors.affiliation: Department of Mechanical Engineering, Widener University, Chester, Pennsylvania 19013, USA. zhuang@mail.widener.edu
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Huang
authors.forename: William R
authors.initials: WR
authors.lastname: Clark
authors.forename: Dayong
authors.initials: D
authors.lastname: Gao
mesh_terms: D015312:Hemodialysis Solutions / Q000737:chemistry; D006801:Humans; D008962:Models, Theoretical; D008970:Molecular Weight; D006435:Renal Dialysis / Q000379:methods; D014508:Urea / Q000737:chemistry / Q000378:metabolism
chemical_list: D015312:Hemodialysis Solutions; D014508:Urea