title: Current treatment of leptomeningeal metastases: systemic chemotherapy, intrathecal chemotherapy and symptom management.
abstract: Treatment of leptomeningeal metastases is multifaceted and includes symptomatic therapy, intrathecal and systemic chemotherapy, and radiotherapy. As the majority of patients have widespread incurable systemic tumor, treatment is predominantly palliative; however, some patients with leukemia, lymphoma or breast cancer may have prolonged remissions and the possibility of cure.
authors.affiliation: Norris Cancer Center, University of Southern California, Los Angeles, Ca. 90089, USA.
authors.forename: Stacey L
authors.initials: SL
authors.lastname: Berg
authors.forename: Marc C
authors.initials: MC
authors.lastname: Chamberlain
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D007938:Leukemia / Q000473:pathology; D008223:Lymphoma / Q000473:pathology; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D009369:Neoplasms / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents