title: Dynamic imaging of the lungs using x-ray phase contrast.
abstract: High quality real-time imaging of lungs in vivo presents considerable challenges. We demonstrate here that phase contrast x-ray imaging is capable of dynamically imaging the lungs. It retains many of the advantages of simple x-ray imaging, whilst also being able to map weakly absorbing soft tissues based on refractive index differences. Preliminary results reported herein show that this novel imaging technique can identify and locate airway liquid and allows lung aeration in newborn rabbit pups to be dynamically visualized.
authors.affiliation: Monash Centre for Synchrotron Science, Monash University, Victoria 3800, Australia.
authors.forename: R A
authors.initials: RA
authors.lastname: Lewis
authors.forename: N
authors.initials: N
authors.lastname: Yagi
authors.forename: M J
authors.initials: MJ
authors.lastname: Kitchen
authors.forename: M J
authors.initials: MJ
authors.lastname: Morgan
authors.forename: D
authors.initials: D
authors.lastname: Paganin
authors.forename: K K W
authors.initials: KK
authors.lastname: Siu
authors.forename: K
authors.initials: K
authors.lastname: Pavlov
authors.forename: I
authors.initials: I
authors.lastname: Williams
authors.forename: K
authors.initials: K
authors.lastname: Uesugi
authors.forename: M J
authors.initials: MJ
authors.lastname: Wallace
authors.forename: C J
authors.initials: CJ
authors.lastname: Hall
authors.forename: J
authors.initials: J
authors.lastname: Whitley
authors.forename: S B
authors.initials: SB
authors.lastname: Hooper
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006801:Humans; D008168:Lung / Q000473:pathology*; D011817:Rabbits; D011856:Radiographic Image Enhancement; D011858:Radiographic Magnification; D013902:Radiography, Thoracic / Q000379:methods*; D012119:Respiration; D013997:Time Factors; D014965:X-Rays