title: Understanding the genesis of psychotic disorder: issues in the prediction and prophylaxis of those at 'ultra-high risk'.
abstract: OBJECTIVE
  Recent research is starting to identify individuals at an increased risk of developing a psychotic disorder. This review seeks to identify the 'state of the art' with respect to the clinical identification and treatment of individuals at 'ultra-high risk'.
  
  
  METHODS
  The research and clinical literature are reviewed with respect to a wide range of predictors relevant across development.
  
  
  RESULTS
  The review draws on evidence from childhood and adolescence to suggest that a range of biological, cognitive, personality, and social features are predictive of, but often not specific to, psychosis within the context of the diathesis-stress model. Much evidence supports the view that environmental stressors act in combination with vulnerability factors to increase risk of transition, often during late adolescence and early adulthood.
  
  
  CONCLUSIONS
  Recent clinical research has used both retrospective and prospective means of identifying individuals at ultra-high risk and has made substantial gains in predicting transition. The clinical implications of their identification are discussed in the context of current pharmacological and psychosocial treatment studies. However, significant unresolved clinical and ethical issues remain with both types of study.
authors.affiliation: School of Psychology, University College London, UK. o.mason@ucl.ac.uk
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Mason
authors.forename: Julie
authors.initials: J
authors.lastname: Beavan-Pearson
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000328:Adult; D003071:Cognition; D006801:Humans; D008960:Models, Psychological; D010551:Personality; D011618:Psychotic Disorders / Q000209:etiology* / Q000503:physiopathology*; D012307:Risk Factors; D012919:Social Behavior; D013315:Stress, Psychological