title: Inotropic response of the myocardium in rats with postinfarction cardiosclerosis exposed to extrasystolic treatment.
abstract: The inotropic response of the myocardium to extrasystolic treatment was studied on isolated perfused papillary muscles from rats with postinfarction cardiosclerosis. The development of postinfarction cardiosclerosis was accompanied by a decrease in myocardial excitability. The amplitude of extrasystolic contractions in the remodeled myocardium far surpassed the control. However, the amplitude of postextrasystolic contraction did not surpass that in normal contraction-relaxation cycle. Our results suggest that the ability of the sarcoplasmic reticulum in cardiomyocytes to accumulate Ca2+ is impaired during postinfarction remodeling.
authors.affiliation: Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. ugdina@mail.ru
authors.forename: D S
authors.initials: DS
authors.lastname: Kondrat'eva
authors.forename: S A
authors.initials: SA
authors.lastname: Afanas'ev
authors.forename: L P
authors.initials: LP
authors.lastname: Falaleeva
authors.forename: V P
authors.initials: VP
authors.lastname: Shakhov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004558:Electric Stimulation; D006352:Heart Ventricles / Q000378:metabolism; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D010210:Papillary Muscles / Q000502:physiology; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D013599:Systole
chemical_list: D000889:Anti-Arrhythmia Agents; D002118:Calcium