title: A study of fine needle aspiration cytology of salivary gland lesions with histopathological corroboration.
abstract: The diagnostic utility of fine needle aspiration cytology as initial work up of salivary gland enlargement was assessed in one hundred and eighty-five salivary gland specimens over three years period and corroborated with histopathology, whenever feasible. All smears were evaluated according to cell size, amount of cytoplasm, cytologic atypia and presence of lymphocytes. (a) Variable cytologic appearances of pleomorphic salivary adenoma were observed. (b) Cellular pleomorphic adenoma and adenoid cystic carcinoma showed basaloid cell features. (c) Tumours with intermediate size cells and bland cytology included low grade muco-epidermoid carcinoma and cystic lesions. (d) Warthin's tumour, oncocytoma, salivary duct carcinoma and high grade muco-epidermoid carcinoma revealed large cells and abundant cytoplasm with or without atypia. A major diagnostic categories were inflammatory lesions (n = 7 5), cystic lesions (n = 9), benign tumours (n = 81), malignant neoplasms (n = 1 8) and normal acinar pattern (n = 2). Malignant tumours included muco-epidermoid carcinoma (n = 5), adenoid cystic carcinoma (n = 3), acinic cell carcinoma (n = 2), adenocarcinoma (n= 2), squamous cell carcinoma (n = 1), undifferentiated carcinoma (n= 4) and malignant lymphoma (n = 1). Histopathological correlation was possible in 40% of benign and 80% of malignant neoplasms. The overall sensitivity, specificity and diagnostic accuracy were very high. So it can be concluded that fine needle aspiration cytology can play important role in early diagnosis and subsequent therapeutic planning of salivary gland lesions.
authors.affiliation: Department of Pathology, RG Kar Medical College, Kolkata.
authors.forename: Anjali
authors.initials: A
authors.lastname: Bandyopadhyay
authors.forename: Tushar Kanti
authors.initials: TK
authors.lastname: Das
authors.forename: Kalpana
authors.initials: K
authors.lastname: Raha
authors.forename: Ganesh Chandra
authors.initials: GC
authors.lastname: Hati
authors.forename: Pradip Kumar
authors.initials: PK
authors.lastname: Mitra
authors.forename: Anjali
authors.initials: A
authors.lastname: Dasgupta
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012680:Sensitivity and Specificity; D012793:Sialadenitis / Q000473:pathology*