Effect of ethanol on the growth and differentiation of spinal motoneurons and possibility of correcting this effect in vitro.
We studied the effect of ethanol on the growth and differentiation of spinal cells in 14-day chick embryos in vitro and the possibility of correcting the destructive changes with dolivin (antioxidant). Ethanol blocked migration of glial cells and growth of axons. Addition of dolivin into the nutrient medium together with ethanol prevented the effect of ethanol and stimulated axon growth and migration of glial cells.
Museridze
D P
DP
Laboratory of Neuromorphology, IS Beritashvili Institute of Physiology, Academy of Sciences of Georgia, Tbilisi. nanajaparidze2000@yahoo.com
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D002642:Chick Embryo; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D009046:Motor Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology / Q000254:growth & development; D046509:Tissue Culture Techniques
D000975:Antioxidants; D000431:Ethanol