Infrared analysis of bone in health and disease.
Infrared spectroscopy, microspectroscopy, and microspectroscopic imaging have been used to probe the composition and physicochemical status of mineral and matrix of bone in normal and diseased tissues using a series of validated parameters that reflect quantitative and qualitative properties. In this review, emphasis is placed on changes in bone's composition and physiochemical status during osteoporosis and the impact of currently used therapeutics on these parameters, although the impact of infrared microscopy in other pathological states is briefly discussed.
Boskey
Adele
A
Weill Medical College of Cornell University, Program in Musculoskeletal Integrity, Hospital for Special Surgery, Department of Biochemistry, New York, New York 10021, USA.
Mendelsohn
Richard
R
D000818:Animals; D001842:Bone and Bones / Q000503:physiopathology*; D002113:Calcification, Physiologic; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D011379:Prognosis; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D016896:Treatment Outcome