Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H-pyrimidine-2,4-diones.
A stepwise synthetic approach involving substitution of 6-chloro-1,3-dialkyluracils (5 and 6) with 3-(tert-amino)-2-hydroxypropylamines and subsequent acylation at C5 of uracil has been used to synthesize pyrimidinediones 27-33 in 61-89% overall yield. The conformational aspects of the new molecules based upon NMR data have been discussed.
Singh
Palwinder
P
Department of Chemistry, Guru Nanak Dev University, Amritsar, 143005, India. palwinder_singh_2000@yahoo.com
Paul
Kamaldeep
K
Holzer
Wolfgang
W
D000215:Acylation; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011437:Propylamines / Q000737:chemistry; D011744:Pyrimidinones / Q000138:chemical synthesis*; D014498:Uracil / Q000031:analogs & derivatives / Q000737:chemistry
D011437:Propylamines; D011744:Pyrimidinones; D014498:Uracil