Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes.
A screening study was conducted to examine the effect of a series of synthesized pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes. Sixteen compounds were tested, ten of which showed an inhibitory effect on the growth of promastigotes. Compound 1 demonstrated potent antileishmanial activity, followed by compounds 3 and 7. Some compounds showed less significant activities, while others exhibited little or no activity. Some of these compounds may be potential candidates for future treatment of leishmaniasis.
Al-Qahtani
Ahmed
A
Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Siddiqui
Yunus M
YM
Bekhit
Adnan A
AA
El-Sayed
Ola A
OA
Aboul-Enein
Hassan Y
HY
Al-Ahdalb
Mohammed N
MN
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D011720:Pyrazoles; D011804:Quinolines