Increased plasma TGF-beta 1 level in patient with salivary gland carcinoma after renal transplantation.
TGF-beta1 maintains homeostasis of rapidly proliferating cells, therefore is a potential tumor suppressor of non-malignant cells. Malignant transformation alters TGF-beta1 signalling pathway, turning it into a stimulator of tumor progression. We describe the case of 54 year old renal transplant patient with highly increased plasma TGF-beta1 level and planoepithelial carcinoma originating from parotid salivary gland. We discuss the role of TGF-beta1 in promotion of carcinogenesis and probable utility in prognosis of malignancy.
Boratyńska
Maria
M
Department of Nephrology and Transplant Medicine, Wrocław Medical University, Poland. Maria.Boratynska@poczta.onet.pl
Watorek
Ewa
E
Falkiewicz
Krzysztof
K
Banasik
Mirosław
M
D002277:Carcinoma / Q000097:blood* / Q000209:etiology*; D017809:Fatal Outcome; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000097:blood* / Q000209:etiology*; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1