[Fluorescence spectroscopy and imaging for optical biopsy].
In the past few years extensive attention has turned toward optical biopsy, because of its ability to perform noninvasive, real time and accurate diagnosis of tissue pathologies, especially precancer. Fluorescence spectroscopy is one of a series of techniques widely developed for optical biopsy, and can be generally divided into two categories: fluorescence spectroscopy and imaging. This paper reviews the applications of autofluorescence and exogenous fluorescence to optical biopsy, and the principle and advantages as well as the clinic applications of various steady-state and time-resolved fluorescence spectroscopy and imaging techniques. Furthermore, the development perspectives of optical biopsy by using fluorescence spectroscopy and imaging are also briefly discussed.
Li
Bu-hong
BH
Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China.
Xie
She-sen
SS
D001706:Biopsy / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000295:instrumentation* / Q000379:methods*