title: [Pituitary-adrenal axis system condition in patients with open angle glaucoma].
abstract: Our study included 71 patients (38 males and 33 females) with diagnosed open angle glaucoma and healthy 71 persons for control group. Their age ranged from 45 to 70. The patients and healthy persons were divided into three groups: I group--45-55 years old persons, II group--55-65 years old persons, III group--65-75 years old persons. Examination included ophthalmologic and hormonal research. To assess the function of pituitary-adrenal axis, we measured the concentrations of cortisol, aldosterone and adrenocorticotropic hormone (ACTH) in the plasma of patients and control groups by radioimmunoassay method. The level of ACTH was decreased in I and II groups of females and in III group of males. The level of cortisol was increased in all--I, II and III groups of males. Aldosterone was decreased in III group of males and in I and III groups of females. According to our studies there were some changes in secretion of these hormones as well as in their regulation. The findings confirmed the role pituitary-adrenal axis of in the regulation of IOP. In compliance to our data, the investigation of the hormonal status of patients with glaucoma is recommended for complete understanding of glaucoma etiology and pathogenesis.
authors.affiliation: Al. Natishvili Institute of Experimental Morphology of the Academy of Sciences of Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Dzhodzhua
authors.forename: Ts
authors.initials: Ts
authors.lastname: Sumbadze
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology*
chemical_list: D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone