title: Activated proteinkinase B in breast cancer.
abstract: The content of activated (phosphorylated) form of proteinkinase B in tumors and homologous tissues of 46 patients with breast cancer was measured by enzyme immunoassay. Activity of proteinkinase B was increased in tumors of 48% patients in comparison with homologous histologically unchanged tissue. Activity of proteinkinase B in hormone-dependent mammary tumors was significantly higher than in tumor tissue from patients with negative receptor status.
authors.affiliation: N. N. Blokhin Russian Oncological Research Center, Russian Academy of Medical Sciences, Moscow. cesaro@front.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Shcherbakov
authors.forename: E S
authors.initials: ES
authors.lastname: Gershtein
authors.forename: O A
authors.initials: OA
authors.lastname: Anurova
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D011960:Receptors, Estrogen; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt