Modulation of cellular immune response by orbifloxacin in noninfected and E. coli-infected mice.
The studies were conducted on noninfected and Escherichia (E) coli-infected mice treated with orbifloxacin administered orally 10 times at 24-hr intervals at a dose of 2.5 mg/kg. Orbifloxacin did not change the activity of peritoneal macrophages in noninfected mice. Administration of orbifloxacin in E. coli-infected mice modulated the effects of infection on the percentage of phagocyting macrophages, the percentage of NBT-positive cells, and nitric oxide production. Orbifloxacin did not affect the synthesis and release of interleukin-1 by macrophages. Orbifloxacin exerted a modulating effect on the subsets of lymphocytes in thymus, spleen, and mesenteric lymph node cells in noninfected and E. coli-infected mice.
Szczypka
Marianna
M
Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Agricultural University, Wrocław, Poland. marianna@ozi.ar.wroc.pl
Gaweda
Bartosz
B
Obmińska-Mrukowicz
Bozena
B
D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology
D007375:Interleukin-1; D009569:Nitric Oxide; D002939:Ciprofloxacin; C095163:orbifloxacin