title: Association of interleukin-1 gene polymorphisms with dementia in a community-based sample: the Honolulu-Asia Aging Study.
abstract: The interleukin-1 (IL-1) pro-inflammatory cytokine family participates in inflammatory processes and vessel damage involved in neurodegeneration. Recent studies suggest that Alzheimer's disease (AD) and vascular dementia (VaD) may share genetic risk factors. In this study, the frequency of polymorphisms in the genes coding for interleukin (IL)-1alpha, IL-1beta and the IL-1 receptor antagonist (RN) and their genotype associations with late-onset AD and VaD were determined in a Japanese-American cohort of men (n=931) participating in the Honolulu-Asia Aging Study (HAAS). A significant association was found between the IL-1beta (-511) and IL-1RN (+2018) polymorphisms and AD, suggesting that these variants confer an increased risk. Possessing the IL-1beta (-511) T/T genotype was also associated with VaD. There was no difference in the IL-1beta (+3953) frequency among the groups. Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia.
authors.affiliation: Toxicology and Molecular Biology Branch, Biostatistics Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. byucesoy@cdc.gov
authors.forename: Berran
authors.initials: B
authors.lastname: Yucesoy
authors.forename: Rita
authors.initials: R
authors.lastname: Peila
authors.forename: Lon R
authors.initials: LR
authors.lastname: White
authors.forename: Kim Ming
authors.initials: KM
authors.lastname: Wu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Johnson
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kashon
authors.forename: Michael I
authors.initials: MI
authors.lastname: Luster
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003704:Dementia / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors / Q000235:genetics; D012111:Residence Characteristics; D012189:Retrospective Studies
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D007375:Interleukin-1; D017472:Receptors, Interleukin-1