Antidiabetic stilbene and anthraquinone derivatives from Rheum undulatum.
The antidiabetic-activity-guided fractionation and isolation of the 80% EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin (1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, 42.3%, respectively.
Choi
Sang Zin
SZ
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
Lee
Sung Ok
SO
Jang
Ki Uk
KU
Chung
Sung Hyun
SH
Park
Sang Hyun
SH
Kang
Hee Chol
HC
Yang
Eun Young
EY
Cho
Hi Jae
HJ
Lee
Kang Ro
KR
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008813:Mice, Inbred ICR; D012250:Rheum / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000880:Anthraquinones; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013267:Stilbenes