Positive ion pair cooperativity exhibited for the binding of phosphate under physiological conditions.
The synthesis of a heteroditopic receptor which exhibits positive cooperativity for the binding of phosphate ion pairs under physiological conditions. Optimised complementarity between crown ether host and metal guest leads to increased binding affinity, Ka.
Gunning
Patrick T
PT
University of Glasgow, Joseph Black Building, Dept. of Chemistry, Glasgow, UKG12 8QQ. patrick.gunning@yale.edu
D001665:Binding Sites; D032701:Biomimetics / Q000379:methods*; D043844:Crown Ethers / Q000737:chemistry*; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007477:Ions; D008024:Ligands; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D010710:Phosphates / Q000737:chemistry*; D013816:Thermodynamics; D017186:Titrimetry
D043844:Crown Ethers; D000080027:Cyclams; D006571:Heterocyclic Compounds; D007477:Ions; D008024:Ligands; D008670:Metals; D010710:Phosphates; C038072:cyclen