Effects of (-)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart.
The present study was designed to elucidate the antioxidant effect of (-)-epicatechin in streptozotocin (STZ)-induced diabetes in rats. Intraperitoneal administration of (-)-epicatechin at doses of 15 and 30 mg/kg to diabetic rats for a period of 35 days resulted in a significant decrease in blood glucose, thiobarbituric acid reactive substances and hydroperoxides and a significant increase in the concentration of glutathione and the activities of catalase, superoxide dismutase and glutathione peroxidase. (-)-Epicatechin at a dose of 30 mg/kg was found to be more effective. Administration of insulin to diabetic rats normalized the changes caused by STZ.
Quine
Sabarimuthu Darlin
SD
School of Chemical and Biotechnology, Shanmugha Arts, Science, Technology and Research Academy, Deemed University, Thirumalaisamudram, Thanjavur-613402, Tamil Nadu, India. Darstash@chem.sastra.edu
Raghu
Pamakanthan S
PS
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002392:Catechin / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002392:Catechin; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione