Linkage analysis of two families with X-linked recessive congenital motor nystagmus.
X-linked recessive congenital motor nystagmus was identified in two Chinese families living in the Guangdong province of China. Nystagmus was noticed in early childhood. Only males in the families were affected and all obligate carriers did not have nystagmus. Linkage study was performed using microsatellite markers at about 10 cM intervals on the X chromosome. The nystagmus in these two families is linked to markers in the region of chromosome Xq23-q27, including DXS1001, DXS8009, and DXS1047. DXS1047 gave the highest lod score of 3.53 at theta = 0.
Guo
Xiangming
X
Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
Li
Shiqiang
S
Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
Jia
Xiaoyun
X
Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
Xiao
Xueshan
X
Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
Wang
Panfeng
P
Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China.
Zhang
Qingjiong
Q
Key Laboratory of Ophthalmology of the Ministry of Education, Sun Yat-sen University, Guangzhou, People's Republic of China. qingjiongzhang@yahoo.com.|Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 Xianlie Road, 510060, Guangzhou, People's Republic of China. qingjiongzhang@yahoo.com.
D041321:Chromosomes, Human, X; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D020417:Nystagmus, Congenital / Q000235:genetics*; D010375:Pedigree