title: Protective properties of synthetic peptides of outer meningococcal membrane.
abstract: Peptide fragments of conservative sites of PorA, OpaB, and NspA proteins of the outer membrane of serogroup B meningococci were synthesized. These peptides caused a pronounced protective effect in immunized mice infected with virulent homologous and heterologous strains of serogroups B and A meningococci. The protective effect appreciably increased, if the studied peptides were associated in a polycomponent preparation, which can be used in the construction of meningococcal bivalent B+A vaccine.
authors.affiliation: MM Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow. ovkot.2003@mail.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Kotelnikova
authors.forename: O V
authors.initials: OV
authors.lastname: Chibiskova
authors.forename: V A
authors.initials: VA
authors.lastname: Nesmeyanov
authors.forename: A P
authors.initials: AP
authors.lastname: Alliluev
authors.forename: O V
authors.initials: OV
authors.lastname: Volpina
authors.forename: D O
authors.initials: DO
authors.lastname: Koroev
authors.forename: M N
authors.initials: MN
authors.lastname: Zhmak
authors.forename: M A
authors.initials: MA
authors.lastname: Titova
authors.forename: V T
authors.initials: VT
authors.lastname: Ivanov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control; D022401:Meningococcal Vaccines; D051379:Mice; D008969:Molecular Sequence Data; D038541:Neisseria meningitidis, Serogroup B / Q000737:chemistry / Q000378:metabolism* / Q000472:pathogenicity; D010455:Peptides / Q000235:genetics / Q000276:immunology*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D022401:Meningococcal Vaccines; D010455:Peptides