title: [Association of -160(C-->A) polymorphism in CDH1 gene with gastric cancer risk in Fujian Chinese population].
abstract: OBJECTIVE
  CDH1, encoding E-cadherin, is an important tumor suppressor gene. The present study aims to investigate the association of -160(C-->A) polymorphism in CDH1 gene with susceptibility to gastric cancer in Fujian province.
  
  
  METHODS
  One hundred and two patients from independent families and 101 healthy control subjects were analyzed. Genotype analysis was performed through polymerase chain reaction-based denaturing high performance liquid chromatography. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression model.
  
  
  RESULTS
  The frequencies of -160(C-->A) polymorphism CC, CA and AA genotype in case group and controls were 58(56.9%), 38(37.3%)ì6(5.9%) and 55(54.5%), 41(40.6%), 5(5%), respectively. AA genotype did not present a significantly increased risk for gastric cancer (OR=1.12; 95% CI:0.32-3.95). No association was found between A allele and clinicopathological characteristics of gastric cancer.
  
  
  CONCLUSIONS
  -160(C-->A) polymorphism in CDH1 gene promoter region may not be in association with genetic susceptibility to gastric cancer in Chinese population from Fujian.
authors.affiliation: Department of Oncology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, Fujian, PR China. songchuangui@yahoo.com
authors.forename: Chuan-gui
authors.initials: CG
authors.lastname: Song
authors.forename: Chang-ming
authors.initials: CM
authors.lastname: Huang
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.forename: Hui-shan
authors.initials: HS
authors.lastname: Lu
authors.forename: Xiang-fu
authors.initials: XF
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics*; D002681:China; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins