title: Applications of gene targeting technology to mental retardation and developmental disability research.
abstract: The human and mouse genome projects elucidated the sequence and position map of innumerous genes expressed in the central nervous system (CNS), advancing our ability to manipulate these sequences and create models to investigate regulation of gene expression and function. In this article, we reviewed gene targeting methodologies with emphasis on applications to CNS development and neurodevelopmental disorders.
authors.affiliation: Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37203, USA.
authors.forename: Aurea F
authors.initials: AF
authors.lastname: Pimenta
authors.forename: Pat
authors.initials: P
authors.lastname: Levitt
mesh_terms: D000483:Alleles; D000818:Animals; D002648:Child; D002658:Developmental Disabilities / Q000235:genetics*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D019426:Integrases / Q000494:pharmacology; D008607:Intellectual Disability / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D017354:Point Mutation / Q000235:genetics
chemical_list: C045073:Cre recombinase; D019426:Integrases