Avian flu: isolation of drug-resistant H5N1 virus.
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
Le
Q Mai
QM
National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
Kiso
Maki
M
Someya
Kazuhiko
K
Sakai
Yuko T
YT
Nguyen
T Hien
TH
Nguyen
Khan H L
KH
Pham
N Dinh
ND
Ngyen
Ha H
HH
Yamada
Shinya
S
Muramoto
Yukiko
Y
Horimoto
Taisuke
T
Takada
Ayato
A
Goto
Hideo
H
Suzuki
Takashi
T
Suzuki
Yasuo
Y
Kawaoka
Yoshihiro
Y
D000081:Acetamides / Q000008:administration & dosage* / Q000494:pharmacology / Q000600:supply & distribution / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D004252:DNA Mutational Analysis; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005289:Ferrets; D006146:Guanidines; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D020128:Inhibitory Concentration 50; D009154:Mutation / Q000235:genetics; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D053139:Oseltamivir; D016133:Polymerase Chain Reaction; D011714:Pyrans; D012794:Sialic Acids; D053243:Zanamivir
D000081:Acetamides; D006146:Guanidines; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D011714:Pyrans; D012794:Sialic Acids; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir