title: Polyamidoamine dendrimers used as solubility enhancers of ketoprofen.
abstract: Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.
authors.affiliation: Laboratory of Structural Biology, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China. yycheng@mail.ustc.edu.cn
authors.forename: Cheng
authors.initials: C
authors.lastname: Yiyun
authors.forename: Xu
authors.initials: X
authors.lastname: Tongwen
authors.forename: Fu
authors.initials: F
authors.lastname: Rongqiang
mesh_terms: D050091:Dendrimers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000737:chemistry*; D015394:Molecular Structure; D011073:Polyamines / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D050091:Dendrimers; D011073:Polyamines; D012996:Solutions; D007660:Ketoprofen