title: Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH.
authors.affiliation: Center for Drug Chemistry, Moscow, 119815 , Russia.
authors.forename: Nadezhda V
authors.initials: NV
authors.lastname: Kovalevskaya
authors.forename: Yegor D
authors.initials: YD
authors.lastname: Smurnyy
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Polshakov
authors.forename: Berry
authors.initials: B
authors.lastname: Birdsall
authors.forename: Alan F
authors.initials: AF
authors.lastname: Bradbury
authors.forename: Tom
authors.initials: T
authors.lastname: Frenkiel
authors.forename: James
authors.initials: J
authors.lastname: Feeney
mesh_terms: D001665:Binding Sites; D003460:Crystallization; D018360:Crystallography, X-Ray; D005493:Folic Acid Antagonists / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D009249:NADP / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D011487:Protein Conformation; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry*; D014295:Trimethoprim / Q000737:chemistry*
chemical_list: D005493:Folic Acid Antagonists; D009249:NADP; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase