Transfusion-related acute lung injury.
OBJECTIVE
Transfusion-related acute lung injury is an uncommon complication of blood transfusion typically manifested by shortness of breath, fever, and hypotension. Transfusion-related acute lung injury is an important cause of transfusion-related morbidity and mortality.


RESULTS
Much about the pathogenesis, treatment, and prevention of transfusion-related acute lung injury is poorly understood or is controversial. There is increasing recognition that transfusion-related acute lung injury is an important clinical syndrome, causing most transfusion-related deaths.


CONCLUSIONS
In this report, what is known about transfusion-related acute lung injury is summarized with particular emphasis on recent studies. Some of the areas in which knowledge and/or consensus are currently lacking are identified.
Webert
Kathryn E
KE
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Blajchman
Morris A
MA
D006801:Humans; D011654:Pulmonary Edema / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D065227:Transfusion Reaction