A bead-alignment device with a bead-sized microchamber on a rotating cylinder for fabrication of a miniaturized probe array.
We have developed a compact bead-alignment device with a bead-sized microchamber on a rotating cylinder. The cylinder fits inside a tube with bead-stock pipes containing different probe-conjugated beads and holes for bead-alignment capillaries. The cylinder rotates in the tube, and the microchamber transfers a single 100-microm-diameter bead from a pipe to one of the capillaries in 10 s. By using this process repeatedly, 'bead arrays', which are miniaturized DNA probe arrays in capillaries, were successfully fabricated.
Noda
Hideyuki
H
Hitachi, Ltd., Central Research Laboratory 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan. noda-h@crl.hitachi.co.jp
Kaise
Masahiro
M
Kohara
Yoshinobu
Y
Okano
Kazunori
K
Kambara
Hideki
H