[Expression of bcl-2 gene in spleen deficiency syndrome in colorectal carcinoma and the regulatory effect of Jianpikangfu decoction].
OBJECTIVE
To investigate the correlation between spleen deficiency syndrome in colorectal carcinoma and bcl-2 gene expression, and observe the regulatory effect of Jianpikangfu decoction.


METHODS
Forty-five advanced colorectal carcinoma patients with spleen deficiency were randomized into Jianpikangfu decoction treatment group with also symptomatic treatment with western medicine and control group in which the patients were given expectant treatment with western medicine. The activity of salivary amylase and bcl-2 expression in the tumor tissues were detected before and after the treatment.


RESULTS
Jianpikangfu decoction in combination with western medicine treatment produced more obvious inhibition of reduction in salivary amylase activity than exclusive western medicine treatment (t=7.822, P<0.01), and significantly lowered the positivity rate of bcl-2 expression (chi2=4.286, P<0.05) in the tumor tissues, which, however, displayed no obvious changes in response to exclusive western medicine treatment.


CONCLUSIONS
Jianpikangfu decoction can inhibit the decrease in salivary amylase activity and regulate bcl-2 gene expression in colorectal carcinoma patients with spleen deficiency syndrome.
Yang
Chuan-biao
CB
Department of Integrated Traditional Chinese and Western Medicine, Guangzhou Fuda Hospital of Oncology, Guangzhou 510300, China. ycbwh@fimmu.com
Xue
Jun
J
Yin
Ping-shan
PS
Zuo
Jian-sheng
JS
Xu
Ke-cheng
KC
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D013158:Splenic Diseases / Q000188:drug therapy / Q000235:genetics; D016711:Yang Deficiency / Q000188:drug therapy / Q000235:genetics
D004365:Drugs, Chinese Herbal; D019253:Proto-Oncogene Proteins c-bcl-2