title: The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
abstract: For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, Republic of Korea. ygsuh@snu.ac.kr
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Sun Nam
authors.initials: SN
authors.lastname: Kim
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Shin
authors.forename: Soon-Sil
authors.initials: SS
authors.lastname: Hyun
authors.forename: Do-Sang
authors.initials: DS
authors.lastname: Lee
authors.forename: Kyung-Hoon
authors.initials: KH
authors.lastname: Min
authors.forename: Sae Mi
authors.initials: SM
authors.lastname: Han
authors.forename: Funan
authors.initials: F
authors.lastname: Li
authors.forename: Eung-Chil
authors.initials: EC
authors.lastname: Choi
authors.forename: Seong-Hak
authors.initials: SH
authors.lastname: Choi
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D008712:Methicillin / Q000494:pharmacology; D008956:Models, Chemical; D009285:Naphthoquinones / Q000737:chemistry* / Q000378:metabolism; D011809:Quinones / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000378:metabolism; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D009285:Naphthoquinones; D011809:Quinones; D012717:Sesquiterpenes; C496018:mansonone F; D014640:Vancomycin; D008712:Methicillin