[Correlation of multiple primary lung cancer with bronchial and alveolar epithelial dysplasia].
To investigate the correlation of multiple primary lung cancer with bronchial epithelial dysplasia and atypical adenomatous hyperplasia of bronchiolo-alveolar epithelium.



Careful pathological examinations were performed on 114 surgical specimens of primary lung carcinoma. The correlation of multiple primary lung cancer with bronchial epithelial dysplasia and atypical adenomatous hyperplasia of bronchiolo-alveolar epithelium was analyzed.



Of 114 cases of primary lung cancer,13 cases of multiple primary lung cancer (11.4 %) was identifiedìwhich consisted of 6 cases containing two primary bronchogenic carcinoma and 7 containing one bronchogenic carcinoma and one bronchiolo-alveolar carcinoma. The rate of multiple primary lung cancers was significantly higher in individuals with high grade bronchial epithelial dysplasia than in those with low grade dysplasia (r=0.238, P<0.05).



Bronchial and alveolar epithelial cells may develop malignancy synchronously or metachronously. The probability of developing multiple primary lung cancer will increase in the lungs with extensive and severe bronchial epithelial dysplasia.
Wang
Guo-feng
GF
Department of Pathology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Lai
Mao-de
MD
Chen
Pei-hui
PH
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D001980:Bronchi / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology*; D020545:Respiratory Mucosa / Q000473:pathology