title: Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid.
abstract: A novel bridged nucleic acid (BNA) analogue, 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid (2',4'-BNA(COC)), was synthesized and incorporated into oligonucleotides. The 2',4'-BNA(COC) modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hari
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Ryo
authors.initials: R
authors.lastname: Ohnishi
authors.forename: Ken
authors.initials: K
authors.lastname: Eguchi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Osaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohishi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D043264:Phosphodiesterase I / Q000378:metabolism; D012911:Snakes; D013696:Temperature
chemical_list: D006571:Heterocyclic Compounds; D009696:Nucleic Acids; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom