title: IgE and FcepsilonRI regulation.
abstract: The high-affinity immunoglobulin (Ig)E receptor, FcepsilonRI, regulates the action of mast cells and basophils and therefore, regulates the expression of atopic disease. There have been several recent observations that demonstrate new behaviors for this receptor. The control of FcepsilonRI expression, control of cell function by FcepsilonRI, and expression of FcepsilonRI on other cell types are important new areas of understanding currently being explored.
authors.affiliation: Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA. dmacglas@jhmi.edu
authors.forename: Donald
authors.initials: D
authors.lastname: MacGlashan
mesh_terms: D000818:Animals; D001491:Basophils / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D011110:Polymorphism, Genetic / Q000276:immunology; D021122:Protein Subunits / Q000235:genetics / Q000502:physiology; D017455:Receptors, IgE / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D021122:Protein Subunits; D017455:Receptors, IgE; D007073:Immunoglobulin E