title: [Synthesis of derivatives of (9S)-12-methylene erythromycin and their antibacterial activity in vitro].
abstract: OBJECTIVE
  To synthesizs of derivatives of (9S)-12-methylene erythromycin possessed potent antibacterial activity.
  
  
  METHODS
  Using erythromycin A as a starting material, via two intermediate compounds protected 12,21-dehydroerythromycin A and 6,7: 12,21-didehydro erythromycin A, several 9-O, 11-O-ethylidene compounds were obtained. During this process, benzyl and isopropyl have been selected as the protecting group. The structures of compounds obtained were confirmed with 13C NMR and MS-FAB. Their antibacterial activity in vitro was tested.
  
  
  RESULTS
  Eleven derivatives of erythromycin were synthesized. Five of them were unknown compounds.
  
  
  CONCLUSIONS
  The preliminary biological test showed that two target compounds exhibited less potent antibacterial activity in vitro.
authors.affiliation: Institute of Material Medica, Chinese Academy of Medical Sciences, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Shi
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.forename: Ping-sheng
authors.initials: PS
authors.lastname: Lei
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin