title: High-density lipoprotein particles may regulate hemostasis in human pregnancy.
abstract: We explored the association of apolipoprotein A-I (the major protein constituent of high-density lipoprotein (HDL)) and fibrin fragment D-dimer (a marker of cross-linked fibrin turnover) in pregnant women. A significant inverse correlation between the levels of apolipoprotein A-I and fibrin fragment D-dimer was observed in both pre-eclamptic and normal pregnant women (rs = -0.459, n = 37 and rs = -0.290, n = 55, respectively), suggesting a major regulating role of HDL in hemostasis during pregnancy.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal. luis_fbelo@yahoo.com
authors.forename: Luís
authors.initials: L
authors.lastname: Belo
authors.forename: Alice
authors.initials: A
authors.lastname: Santos-Silva
authors.forename: Gordon
authors.initials: G
authors.lastname: Lowe
authors.forename: Ann
authors.initials: A
authors.lastname: Rumley
authors.forename: Alexandre
authors.initials: A
authors.lastname: Quintanilha
authors.forename: Irene
authors.initials: I
authors.lastname: Rebelo
mesh_terms: D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D011247:Pregnancy / Q000097:blood* / Q000502:physiology*; D018709:Statistics, Nonparametric
chemical_list: D008075:Lipoproteins, HDL