title: [Clinical study of porous gelatin sphere (YM 670) in transcatheter arterial embolization].
abstract: A clinical study on the use of porous gelatin particles(sterile gelatin embolization material, YM 670, Gelpart) in transcatheter arterial embolization (TAE) was performed in patients with hepatocellular carcinoma, and the efficacy (embolization,anti-tumor effect, recanalization and operationality) and safety (tolerability) were studied. An additive agent comprising porous gelatin particles and low osmolarity contrast media was administered peripherally through a catheter into the hepatic artery proper of 63 patients with hepatocellular carcinoma. Good hepatic arterial embolization was confirmed in all cases (embolization: 100%), and a tumor necrosis effect was obtained in most cases (35/62 patients, 56.5%). Moreover, operationality was assessed as "highly easy to use" or "easy to use" in all cases. Frequencies of adverse events in which a relationship to TAE was not excluded and abnormalities of clinical laboratory data were high at 71.4% and 9 8.4%, respectively. The most common adverse reactions were pyrexia, abdominal pain, queasiness and blood pressure increase;abnormalities in clinical laboratory data included hepatic function with increased AST (GOT), increased ALT (GPT), decreased cholinesterase, increased LDH and increased total bilirubin. These adverse reactions and abnormalities in clinical laboratory data, however, were transient and attributed to the TAE procedure itself, and no adverse reactions related to YM 670 as an embolic material were observed. In addition, with regard to tolerability (safety), the treatment was assessed as suitable for use in all the present cases.
authors.affiliation: Dept. of Radiology, Osaka City University Medical School Hospital.
authors.forename: Ryusaku
authors.initials: R
authors.lastname: Yamada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sawada
authors.forename: Hideo
authors.initials: H
authors.lastname: Uchida
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kumazaki
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ishii
authors.forename: Norio
authors.initials: N
authors.lastname: Nakao
authors.forename: Hironobu
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Taguchi
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005780:Gelatin / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged
chemical_list: C505042:YM 670; D005780:Gelatin