title: 4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300.
abstract: Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Tokyo 142-8501, Japan. hosoe@hoshi.ac.jp
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Toru
authors.initials: T
authors.lastname: Iizuka
authors.forename: Shin-ichirou
authors.initials: S
authors.lastname: Komai
authors.forename: Daigo
authors.initials: D
authors.lastname: Wakana
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itabashi
authors.forename: Koohei
authors.initials: K
authors.lastname: Nozawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Fukushima
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kawai
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D001593:Benzyl Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020036:Onygenales / Q000737:chemistry*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D014665:Vasodilator Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C508103:4-benzyl-3-phenyl-5H-furan-2-one; D001593:Benzyl Compounds; D005663:Furans; D014665:Vasodilator Agents; D011188:Potassium; D002118:Calcium