title: Onset of inflammatory bowel diseases during combined alpha-interferon and ribavirin therapy for chronic hepatitis C: report of two cases.
abstract: We report two patients who developed an inflammatory bowel disease (IBD) shortly after beginning combined alpha-interferon and ribavirin treatment for HCV-related chronic hepatitis. The previous clinical history was negative for IBD in both patients, who developed diarrhoea and rectal bleeding 10 days and 6 months, respectively, after the initiation of therapy. The history, therapeutic management and the possible causal relationships of these cases are discussed.
authors.affiliation: Department of Gastroenterology, IRCCS Policlinico Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Villa
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Rumi
authors.forename: Clementina
authors.initials: C
authors.lastname: Signorelli
authors.forename: Simone
authors.initials: S
authors.lastname: Saibeni
authors.forename: Ersilio
authors.initials: E
authors.lastname: Del Ninno
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrero Bogetto
authors.forename: Roberto
authors.initials: R
authors.lastname: de Franchis
authors.forename: Maurizio
authors.initials: M
authors.lastname: Vecchi
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced*; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin