[Alcoholic ketoacidosis: not rare cause of metabolic acidosis].
Alcoholic ketoacidosis is an often overlooked disorder, which affects chronic ethanol abusers who have usually had a binge culminating in severe vomiting with resulting hypovolemia, acute starvation and then a beta-hydroxybutyrate dominated ketoacidosis (due to the conjonction of enhanced Glucagon/Insuline and NADH/NAD ratios). Although the pathophysiology is complex, the syndrome is quickly reversible with the administration of saline and glucose solutions along with the correction of electrolyte disturbances, often unmasked during the treatment. Insuline and bicarbonates are not indicated. The prognosis, which is excellent, depends mainly on the coexisting acute disorders, which should be purchased and treated appropriately.
Sibaï
K
K
Clinique médicale 2, Département de médecine interne HUG, 1211 Genève. karimsibai@hotmail.com
Eggimann
P
P
D000138:Acidosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000437:Alcoholism / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D007662:Ketosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy