title: Clomipramine-induced hypersensitivity syndrome with unusual clinical features.
abstract: Drug-induced hypersensitivity syndrome is a severe drug eruption with fatal visceral organ failures associated with human herpesvirus-6 (HHV-6) reactivation. We present a case of clomipramine-induced hypersensitivity syndrome, which displayed in succession two different reactions akin to those described for Gianotti-Crosti syndrome and infectious mononucleosis. HHV-6 reactivation was confirmed serologically after the latter reaction, suggesting that our case may have represented a biphasic reaction to HHV-6 reactivation.
authors.affiliation: Department of Dermatology, Tenri Yorozu Hospital, Nara, Japan. n-you-1@msi.biglobe.ne.jp
authors.forename: Youichi
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kitoh
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D002997:Clomipramine / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood; D004342:Drug Hypersensitivity / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D015654:Herpesvirus 6, Human; D006801:Humans; D006967:Hypersensitivity; D008111:Liver Function Tests; D011537:Pruritus / Q000139:chemically induced; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced
chemical_list: D000929:Antidepressive Agents, Tricyclic; D016207:Cytokines; D002997:Clomipramine