Neurogenic constrictor response of isolated small renal arteries in rats after 2-week simulated microgravity.
The study was aimed at investigation of the effects of 2-week tail suspension upon the constrictor responses of isolated small renal arteries in rats. 1st-2nd-order branches of renal artery were perfused with saline under the constant flow conditions. Constrictor responses to electrical stimulation of periarterial nerves, noradrenaline and serotonin were investigated. In post-suspension rats as compared to controls the response to nerve stimulation was slightly reduced during 15-Hz stimulation, but similar at smaller frequencies. Thus, simulated microgravity has no prominent effect of neurogenic responses of renal vessels, in agreement with non-changed density of periarterial adrenergic nerve plexus. Along with that, in post-suspension rats impairment of prejunctional sympathetic mechanisms might be compensated by augmented sensitivity of vascular smooth muscle to vasoconstrictors.
Kalentchuk
V
V
Faculty of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia. slava102@yandex.ru
Tarasova
O
O
Tsvirkoun
D
D
Vinogradova
O
O
D000818:Animals; D004558:Electric Stimulation; D006614:Hindlimb / Q000098:blood supply / Q000294:innervation / Q000502:physiology; D019417:Hindlimb Suspension; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000294:innervation / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D014661:Vasoconstriction / Q000502:physiology*; D018474:Weightlessness Simulation
D012701:Serotonin; D009638:Norepinephrine