title: Influence of gravity changes induced by parabolic flight on cytokine production in mouse spleen.
abstract: Dysregulation of the immune system has been a well-documented effect of human exposure to a microgravity environment during space flight. These effects have included altered cytokine production, reduced proliferative responses, altered signal transduction pathways and altered distribution of peripheral immune cells. Recent reports have documented immunologic studies performed in-flight. When tested during space flight, delayed-type hypersensitivity was reduced, indicating a dysregulation of cell-mediated immune function. However, the mechanisms by which this occurs remain unclear. The production of cytokines plays a critical role in the ability of a host to mount an immune response against an invading microorganism. In this study, the alteration of cytokine responses in mice following parabolic flight (PF) was investigated.
authors.affiliation: Department of Microbiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kita
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Imanishi
authors.forename: Akira
authors.initials: A
authors.lastname: Fuse
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005260:Female; D015870:Gene Expression / Q000276:immunology; D018471:Hypergravity; D007371:Interferon-gamma / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D013026:Space Flight; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014893:Weightlessness
chemical_list: D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma