title: [Nocardia brasiliensis leg ulcer and nodular lymphangitis in France].
abstract: BACKGROUND
  Nocardia brasiliensis is a very rarely reported cause of chronic phagedenic ulcerations. We report the case of an elderly woman who developed such an infection after falling on her right leg on the road in the Bresse country (an essentially agricultural and bovine-cattle breading region) and developed a chronic phagedenic ulcer secondarily complicated by nodular lymphangitis of the thigh.
  
  
  METHODS
  A 75 year-old woman fell on her right leg on the side of the main road outside her hamlet in the Bresse country and secondarily developed a chronique phagedenic ulceration. We first considered her as suffering from pyoderma gangrenosum. A complete scanning only revealed an autoimmune thyroiditis and a rapidly healing gastric ulceration, and none of the treatments, either local or systemic, helped the skin condition to heal. After 3 weeks of application of a local corticoid ointment, the patient developed fever, general malaise, an exacerbation of her wound and an infiltration of the skin round her knee, together with nodular lymphangitic dissemination. A supplementary bacterial swab disclosed massive proliferation of a slow-growing Gram-positive bacillus, which proved to be Nocardia brasiliensis, together with a methicillino-sensitive Staphylococcus aureus. The treatment with sulfamethoxazole-trimetoprim gave a rash after 12 hours and was changed to amoxicillin and clavulanic acid, which rapidly proved to be permanently effective.
  
  
  CONCLUSIONS
  The revelation of this particular slow-growing bacteria is difficult and requires bacterial swabs. Nocardia brasiliensis is relatively rare in primary skin ulcerations and we discuss the reasons why an elderly women should find this bacteria on the road outside her hamlet in the French countryside. This particular infectious condition requires general scanning, to make sure that the primary skin condition does not extend to other organs. We review the therapeutical options for patients who exhibit allergic reactions to the classically effective antibiotic drugs.
authors.affiliation: Unité de Dermatologie, Centre Hospitalier William Morey, Chalon-sur-Saône.
authors.forename: M
authors.initials: M
authors.lastname: Hamm
authors.forename: J
authors.initials: J
authors.lastname: Friedel
authors.forename: C
authors.initials: C
authors.lastname: Siré
authors.forename: J
authors.initials: J
authors.lastname: Semon
mesh_terms: D000058:Accidental Falls; D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D002908:Chronic Disease; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology* / Q000382:microbiology*; D008205:Lymphangitis / Q000209:etiology; D009615:Nocardia / Q000472:pathogenicity; D009617:Nocardia Infections / Q000150:complications* / Q000188:drug therapy
chemical_list: D019980:Amoxicillin-Potassium Clavulanate Combination