title: Primary squamous cell carcinoma arising from an epithelium-lined cyst of the lacrimal gland.
abstract: A 66-year-old man presented with a slowly enlarging, nontender left orbital mass of 2 months' duration. CT and MRI showed a left lacrimal gland mass with enhancement and internal irregularity of cystic structures. Histopathologic analysis of the biopsy specimen revealed a squamous cell carcinoma arising from an epithelium-lined cyst. The patient underwent left orbital exenteration followed by radiation treatment. No evidence of tumor recurrence was observed after a follow-up of 30 months. We believe this primary squamous cell carcinoma may have arisen either from preexisting lacrimal duct cyst (dacryops) with areas of squamous metaplasia or, less likely, from a choristomatous epithelium-lined cyst of the lacrimal gland. Although rare, this entity should be included in the differential diagnosis of cystic lesions of the lacrimal gland.
authors.affiliation: Department of Ophthalmology, Cullen Eye Institute, and the Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Grant W
authors.initials: GW
authors.lastname: Su
authors.forename: Michael
authors.initials: M
authors.lastname: Patipa
authors.forename: Ramon L
authors.initials: RL
authors.lastname: Font
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003560:Cysts / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D004848:Epithelium / Q000473:pathology; D005134:Eye Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed