Protective properties of synthetic peptides of outer meningococcal membrane.
Peptide fragments of conservative sites of PorA, OpaB, and NspA proteins of the outer membrane of serogroup B meningococci were synthesized. These peptides caused a pronounced protective effect in immunized mice infected with virulent homologous and heterologous strains of serogroups B and A meningococci. The protective effect appreciably increased, if the studied peptides were associated in a polycomponent preparation, which can be used in the construction of meningococcal bivalent B+A vaccine.
Kotelnikova
O V
OV
MM Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow. ovkot.2003@mail.ru
Chibiskova
O V
OV
Nesmeyanov
V A
VA
Alliluev
A P
AP
Volpina
O V
OV
Koroev
D O
DO
Zhmak
M N
MN
Titova
M A
MA
Ivanov
V T
VT
D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control; D022401:Meningococcal Vaccines; D051379:Mice; D008969:Molecular Sequence Data; D038541:Neisseria meningitidis, Serogroup B / Q000737:chemistry / Q000378:metabolism* / Q000472:pathogenicity; D010455:Peptides / Q000235:genetics / Q000276:immunology*
D001425:Bacterial Outer Membrane Proteins; D022401:Meningococcal Vaccines; D010455:Peptides