title: Protective effect of coenzyme Q10 in simvastatin and gemfibrozil induced rhabdomyolysis in rats.
abstract: Administration of simvastatin (80 mg/kg, po. evening dose) and gemfibrozil (600 mg/kg, po twice) for 30 days produced significant decrease in the level of reduced glutathione, superoxide dismutase, catalase and increase in the level of lipid peroxidation and various serum parameters (creatine phosphokinase, lactate dehydrogenase, serum glutamate oxaloacetate transaminase, creatinine, urea and blood urea nitrogen). This suggested involvement of oxidative stress in rhabdomyolysis. Increase in the level of reduced glutathione, superoxide dismutase, catalase and decrease in the level of lipid peroxidation and serum parameters after administration of antioxidant CoQ10 (10 mg/kg.ip) proved the protective effect of CoQ10 in rhabdomyolysis.
authors.affiliation: Department of Pharmacy, Faculty of Technology and Engineering, M.S. University of Baroda, Baroda 390 001, India. mamta_fr2002@yahoo.co.in
authors.forename: Mamta
authors.initials: M
authors.lastname: Farswan
authors.forename: S P
authors.initials: SP
authors.lastname: Rathod
authors.forename: A B
authors.initials: AB
authors.lastname: Upaganlawar
authors.forename: Arvind
authors.initials: A
authors.lastname: Semwal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D002374:Catalase / Q000097:blood; D003067:Coenzymes; D003404:Creatinine / Q000097:blood; D005260:Female; D015248:Gemfibrozil / Q000009:adverse effects*; D005978:Glutathione / Q000097:blood; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects; D015227:Lipid Peroxidation; D016877:Oxidants / Q000494:pharmacology; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000097:blood* / Q000139:chemically induced*; D019821:Simvastatin / Q000009:adverse effects*; D013482:Superoxide Dismutase / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D000960:Hypolipidemic Agents; D016877:Oxidants; D014451:Ubiquinone; D019821:Simvastatin; D003404:Creatinine; D002374:Catalase; D013482:Superoxide Dismutase; C024989:coenzyme Q10; D005978:Glutathione; D015248:Gemfibrozil