title: Acute effects of liver vein occlusion by stent-graft placed in transjugular intrahepatic portosystemic shunt channel: an experimental study.
abstract: The purpose of this study was to evaluate the effects of hepatic vein occlusion by stent-graft used in transjugular intrahepatic portosystemic shunt (TIPS). The experiments were performed in six healthy pigs under general anesthesia. Following percutaneous transhepatic implantation of a port-a-cath in the right hepatic vein, TIPS was created with a stent-graft (Viatorr; W L Gore, Flagstaff, AZ, USA). The outflow from the hepatic vein, blocked by the stent-graft was documented by injection of contrast medium and repeated injections of (99)Tc(m)-labeled human serum albumin through the port-a-cath. After 2 weeks, the outflow was re-evaluated, the pigs were sacrificed, and histopathologic examination of the liver was performed. Occlusion of the hepatic vein by a stent-graft had a short and temporary effect on the outflow. Histopathological examination from the affected liver segment showed no divergent pattern. Stent-grafts used in TIPS block the outflow from the liver vein, but do not have a prolonged circulatory effect and do not affect the liver parenchyma.
authors.affiliation: Department of Radiology, University Hospital, Lund, Sweden. inger.keussen@skane.se
authors.forename: Inger
authors.initials: I
authors.lastname: Keussen
authors.forename: Lennart
authors.initials: L
authors.lastname: Bergqvist
authors.forename: Pehr
authors.initials: P
authors.lastname: Rissler
authors.forename: Wojciech
authors.initials: W
authors.lastname: Cwikiel
mesh_terms: D000818:Animals; D006503:Hepatic Veins / Q000000981:diagnostic imaging* / Q000601:surgery*; D008099:Liver / Q000098:blood supply; D008102:Liver Circulation / Q000502:physiology; D015609:Organotechnetium Compounds; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012709:Serum Albumin; D015607:Stents; D013552:Swine
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012709:Serum Albumin; C107869:technetium Tc 99m serum albumin