title: MAP kinases in immune responses.
abstract: MAP kinases are evolutionarily conserved signaling regulators from budding yeast to mammals and play essential roles in both innate and adaptive immune responses. There are three main families of MAPKs in mammals. Each of them has its own activators, inactivators, substrates and scaffolds, which altogether form a fine signaling network in response to different extracellular or intracellular stimulation. In this review, we summarize recent advances in understanding of the regulation of MAP kinases and the roles of MAP kinases in innate and adaptive immune responses.
authors.affiliation: Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, 77030, USA.
authors.forename: Yong Liang
authors.initials: YL
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000818:Animals; D004789:Enzyme Activation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D020928:Mitogen-Activated Protein Kinases / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
chemical_list: D020928:Mitogen-Activated Protein Kinases