title: [A Case of advanced gastric cancer successfully treated with TS-1/low-dose CDDP as neoadjuvant chemotherapy].
abstract: TS-1 was introduced into the treatment of advanced or recurrent gastric cancer cases. Along with independent administration of TS-1, a high antitumor effect has been reported in combination with various anticancer agents. We report a patient with gastric cancer successfully treated with TS-1 and low-dose CDDP as neoadjuvant chemotherapy. The patient was a 46-year-old man who was diagnosed as type 3 gastric cancer with suspected invasion of the pancreas. Histopathological findings demonstrated the degeneration of cancer cells and fibrosis in the primary tumor. The changes against neoadjuvant chemotherapy were judged to be Grade 3. The treatment was completed without adverse events. TS-1 and low-dose CDDP therapy can be one of the effective methods as neoadjuvant chemotherapy without remarkable toxicity.
authors.affiliation: Dept. of Surgery, Public Kanagi Hospital.
authors.forename: Kyogo
authors.initials: K
authors.lastname: Yamada
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Kageyoshi
authors.initials: K
authors.lastname: Seino
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kobori
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Ebina
authors.forename: Shigeru
authors.initials: S
authors.lastname: Shibata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Sasaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011725:Pyridines / Q000008:administration & dosage; D011788:Quality of Life; D011860:Radiography, Abdominal; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin