Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery.
OBJECTIVE
To investigate whether maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis are markers of preterm delivery.


METHODS
One hundred and forty-one pregnant women were included in this prospective study. Amniotic fluid and maternal serum CRP and PAPP-A concentrations were determined by using commercially available kits. Receiver-operating characteristic (ROC) analysis was performed to determine the efficacy of maternal serum and amniotic fluid CRP and PAPP-A levels in predicting women with preterm delivery.


RESULTS
The prevalence of spontaneous preterm delivery before 37 weeks of gestation was 9.9%. ROC analysis revealed that amniotic fluid CRP level was the only parameter, which had a significant power in the prediction of preterm delivery. The optimum cut-off level was 0.65 mg/L. The sensitivity and specificity were 92.9% and 78.7%, respectively.


CONCLUSIONS
The amniotic fluid CRP level has a high sensitivity and specificity in the prediction of preterm delivery and this may be helpful in predicting preterm delivery during genetic amniocentesis.
Ozer
Kamer T
KT
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Marmara University School of Medicine, Istanbul, Turkey. drkamerozer@hotmail.com
Kavak
Zehra N
ZN
Gökaslan
Hüsnü
H
Elter
Koray
K
Pekin
Tanju
T
D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005820:Genetic Testing; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D047928:Premature Birth / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D012372:ROC Curve; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein; D011266:Pregnancy-Associated Plasma Protein-A