title: Paraquat-induced Fanconi syndrome.
abstract: The ingestion of paraquat, a non-selective herbicide, can be fatal in humans. Paraquat is toxic to multiple organs, including the kidney, heart, gastrointestinal tract and central nervous system. Although paraquat has been established as one cause of acute tubular necrosis, Fanconi syndrome presenting as severe hypophosphataemia after paraquat intoxication has not been reported. Here, we report the case of a 44-year-old Korean woman who presented with generalized proximal tubular dysfunction including aminoaciduria, phosphaturia and glycosuria after paraquat intoxication. We found that severe hypophosphataemia induces deep drowsiness. Renal biopsy findings indicated the presence of acute tubular necrosis that may be reversible.
authors.affiliation: Department of Internal Medicine and Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea.
authors.forename: Hyo W
authors.initials: HW
authors.lastname: Gil
authors.forename: Jong O
authors.initials: JO
authors.lastname: Yang
authors.forename: Eun Y
authors.initials: EY
authors.lastname: Lee
authors.forename: Sae Y
authors.initials: SY
authors.lastname: Hong
mesh_terms: D000328:Adult; D001706:Biopsy; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000473:pathology*; D005260:Female; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D017674:Hypophosphatemia / Q000139:chemically induced / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology; D010269:Paraquat / Q000506:poisoning*
chemical_list: D006540:Herbicides; D010269:Paraquat