title: Follicular lymphoma with bilateral testicular and epididymal involvement: case report and review of the literature.
abstract: Testicular involvement with indolent lymphoma is extremely rare, particularly in the absence of transformation to an aggressive histology. We report a case of a 64-year-old man who presented with cervical lymphadenopathy. Staging CT scans revealed extensive lymphadenopathy as well as bilateral testicular and epididymal masses. Histologic examination of lymph node, bone marrow, and testicular/epididymal biopsies revealed involvement with grade I follicular lymphoma. The patient was started on chemotherapy with cyclophosphamide, vincristine, prednisone, and rituximab in addition to intrathecal methotrexate and testicular radiation. He is now 6 months into therapy and responding well. A review of the literature demonstrated this to be the first confirmed case of testicular and epididymal involvement with grade I follicular lymphoma.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Havard Medical School, Boston, 02115, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Jacobsen
authors.forename: Lesley
authors.initials: L
authors.lastname: Lomo
authors.forename: Frederick
authors.initials: F
authors.lastname: Briccetti
authors.forename: Janina
authors.initials: J
authors.lastname: Longtine
authors.forename: Arnold
authors.initials: A
authors.lastname: Freedman
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004822:Epididymis / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D015182:Lymphatic Irradiation; D008224:Lymphoma, Follicular / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013736:Testicular Neoplasms / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed