Low oxygen [correction of oxygene] tension may defence the bone tissue from unloading simulated osteopenia.
The main task of the present study is to investigate the influences of normobaric gas mixture with lowered PO2 (90-110 mm Hg) on the bones metabolism in rats after hind limb unloaded (HLU). We observed increased the glycosaminoglicans (GAG) concentration in blood serum rats with hind limb unloaded in atmospheric air (AA). An increased activity of acid phosphatase (AcP) and tartratresistant acid phosphatase (TRAcP) in blood serum of rats after HLU was observed. The activities of the alkaline phosphatase (AIP) in blood serum did not change. An increased osteocalcin (OST) and C-terminal Propeptide of type I Collagen (CICP) concentration in blood serum, but parathyroid hormone (PTH) decrease comparatively with the control. The above mentioned biochemistry markers in animals after 28 days unloading in normobaric gas mixture (NGM) were more stable and in spite of the same procedure in AA, all dates were near to the controls.
Berezovskii
V A
VA
A.A. Bogomolets Institute of Physiology, Ukranian National Academy of Sciences, Kiev, Ukraine. vadber@serv.biph.kiev.ua
Litovka
I G
IG
Kostyuchenko
A S
AS
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001851:Bone Diseases, Metabolic / Q000188:drug therapy / Q000503:physiopathology*; D016723:Bone Remodeling / Q000187:drug effects*; D006025:Glycosaminoglycans / Q000378:metabolism; D019417:Hindlimb Suspension; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D015675:Osteocalcin / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology* / Q000627:therapeutic use; D010281:Parathyroid Hormone / Q000378:metabolism; D010313:Partial Pressure; D010446:Peptide Fragments / Q000378:metabolism; D011347:Procollagen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000071681:Tartrate-Resistant Acid Phosphatase; D018474:Weightlessness Simulation
D015415:Biomarkers; D006025:Glycosaminoglycans; D007527:Isoenzymes; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D010100:Oxygen