title: Effect of positive end-expiratory-pressure on regional ventilation in patients with acute lung injury evaluated by electrical impedance tomography.
abstract: OBJECTIVE
  For the treatment of patients with adult respiratory distress syndrome and acute lung injury bedside measurements of regional lung ventilation should be considered for optimizing ventilatory settings. The aim was to investigate the effect of positive end-expiratory pressure (PEEP) on regional ventilation in mechanically ventilated patients at the bedside by electrical impedance tomography.
  
  
  METHODS
  Eight mechanically ventilated patients were included in the study. PEEP levels were increased from 0 to 5, 10, 15 mbar and back to 0 mbar. Regional ventilation in 912 regions of the thorax was investigated at each PEEP by electrical impedance tomography. The obtained regions were divided in four groups: none (none and poorly ventilated regions including chest wall and mediastinum), bad, moderate and well-ventilated regions.
  
  
  RESULTS
  Increasing the PEEP stepwise from 0 to 15 mbar decreased the non-ventilated regions (none: 540 regions at PEEP 0 and 406 regions at PEEP 15). In contrast, the other regions increased (bad: 316 regions at PEEP 0 and 380 regions at PEEP 15; moderate: 40 regions at PEEP 0 and 100 regions at PEEP 15; well: 0 region at PEEP 0 and 34 regions at PEEP 15 (median values)) indicating an improvement of regional ventilation.
  
  
  CONCLUSIONS
  Increasing PEEP in mechanically ventilated patients reduces none ventilated regions (atelectasis). Furthermore, it leads to a shift from none and bad ventilated regions to moderately and well-ventilated regions. Electrical impedance tomography is a bedside technique and might be an alternative to computed tomography scan to assess aerated lung regions.
authors.affiliation: University Göttingen, Emergency and Intensive Care Medicine, Department of Anaesthesiology, Göttingen, Germany. mail@josehinz.de
authors.forename: J
authors.initials: J
authors.lastname: Hinz
authors.forename: O
authors.initials: O
authors.lastname: Moerer
authors.forename: P
authors.initials: P
authors.lastname: Neumann
authors.forename: T
authors.initials: T
authors.lastname: Dudykevych
authors.forename: G
authors.initials: G
authors.lastname: Hellige
authors.forename: M
authors.initials: M
authors.lastname: Quintel
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D017097:Electric Impedance; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology / Q000628:therapy*; D008176:Lung Volume Measurements; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D015656:Respiratory Mechanics / Q000502:physiology*; D014054:Tomography / Q000379:methods*