Temperature and vascular volume effects on gastric ulcerogenesis after cord transection.
Gastric ulcers are an important cause of morbidity and mortality in the critically ill, especially those with CNS injury. We used cervical spinal cord transection (CCT) in the rat to model these ulcers and examined the effect of core body temperature and vascular volume on gastric ulcerogenesis. Hypothermia significantly increased ulcerogenesis compared to euthermia, while maintained euthermia produced ulcer indices not different from sham surgery. Hypovolemia (10% blood volume withdrawal) significantly increased ulcerogenesis compared to hypervolemia (10% of blood volume crystalloid infusion) or sham surgery. These results support crystalloid infusion and maintenance of core body temperature in the clinical setting.
Strain
George M
GM
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA. strain@lsu.edu
Waldrop
Ron D
RD
D000818:Animals; D001810:Blood Volume / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology*; D020896:Hypovolemia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000150:complications* / Q000503:physiopathology*; D013276:Stomach Ulcer / Q000150:complications* / Q000503:physiopathology*