Trichodermamide A and aspergillazine A, two cytotoxic modified dipeptides from a marine-derived fungus Spicaria elegans.
Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
Liu
Rui
R
Key laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China.
Gu
Qian-Qun
QQ
Zhu
Wei-Ming
WM
Cui
Cheng-Bin
CB
Fan
Guo-Tao
GT
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D014871:Water Microbiology
D000970:Antineoplastic Agents; D004151:Dipeptides; C505497:aspergillazine A; C476747:trichodermamide A