Genetics. Motivating hotspots.
Only recently have we begun to characterize fine-scale recombination rates in mammals. In her Perspective, Przeworski discusses the work by Myers et al. in which linkage disequilibrium data have been used to produce a high-resolution recombination map for most of the human genome. More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity.
Przeworski
Molly
M
Department of Human Genetics, University of Chicago, 920 East 57th Street, 507F CLSC, Chicago, IL 60637, USA. mfp@uchicago.edu
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D011995:Recombination, Genetic / Q000235:genetics*