Macrophage polarization comes of age.
Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).
Mantovani
Alberto
A
Istituto Clinico Humanitas, and Institute of General Pathology, University of Milan, Milan, Italy.
Sica
Antonio
A
Locati
Massimo
M
D002454:Cell Differentiation / Q000276:immunology*; D008264:Macrophages / Q000145:classification* / Q000166:cytology / Q000276:immunology*