Kidney dysfunction in the recipients of liver transplants.
1. Pretransplant kidney function is an important predictor of posttransplant kidney function. 2. Chronic kidney disease is present in 20% of liver transplant recipients by 5 years. 3. Kidney function is impacted by pretransplant management of the consequences of the hepatorenal syndrome. 4. The use of calcineurin inhibitor (CNI)-based immunosuppression is an important factor in the development of chronic kidney disease, and the use of mycophenolic acid- or sirolimus-based immunosuppression with reduced-dose CNI may be of benefit.
Wilkinson
Alan
A
Department of Medicine, Kidney and Pancreas Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1693, USA. awilkinson@mednet.ucla.edu
Pham
Phuong-Thu
PT
D065095:Calcineurin Inhibitors; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000378:metabolism; D016031:Liver Transplantation / Q000009:adverse effects*; D012307:Risk Factors
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents