Synthesis and antioxidant properties of some indole ethylamine derivatives as melatonin analogs.
The synthesis and lipid peroxidation (LP) inhibition activity of several novel indole melatonin analogues are reported. Compounds have shown variable antioxidant features depending on the substitution pattern. Melatonin and the antioxidant reference compound butyl hydroxy toluen (BHT) were used to compare the antioxidant capability of the compounds synthesized.
Ates-Alagoz
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy (ECZACILIK), University of Ankara, Turkey.
Buyukbingol
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Buyukbingol
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E
D000215:Acylation; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D005021:Ethylamines / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008550:Melatonin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D014363:Tryptamines / Q000138:chemical synthesis
D000975:Antioxidants; D005021:Ethylamines; D007202:Indicators and Reagents; D007211:Indoles; D014363:Tryptamines; D008550:Melatonin