Rational design and synthesis of highly potent beta-glucocerebrosidase inhibitors.
Zhu
Xiaoxiang
X
Amicus Therapeutics Inc., Cranbury, NJ 08512, USA.
Sheth
Kamlesh A
KA
Li
Shihong
S
Chang
Hui-Hwa
HH
Fan
Jian-Qiang
JQ
D002236:Carbohydrate Conformation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors*; D050112:Imino Pyranoses / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D050112:Imino Pyranoses; D010880:Piperidines; C098432:isofagomine; D005962:Glucosylceramidase