Time-kill curves as a tool for targeting ceftazidime serum concentration during continuous infusion for treatment of septicaemic melioidosis.
Melioidosis is a fatal community-acquired infection endemic in tropical areas. Ten isolates of the causative microorganism were subjected to time-kill study using a range of ceftazidime concentrations. This study demonstrated that a ceftazidime concentration of eight times the minimum inhibitory concentration yielded an optimal bactericidal effect and should be the target concentration administered by continuous infusion.
Soontornpas
Cheardchai
C
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Khon Kaen University, Friendship Highway, Khon Kaen 40002, Thailand. chesoo@kku.ac.th
Saraya
Sumarn
S
Chulasiri
Malyn
M
Chindavijak
Busba
B
Mootsikapun
Piroon
P
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood*; D016957:Burkholderia pseudomallei / Q000187:drug effects; D002442:Ceftazidime / Q000008:administration & dosage* / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007262:Infusions, Intravenous; D008554:Melioidosis / Q000097:blood* / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D018805:Sepsis / Q000097:blood* / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002442:Ceftazidime