title: Adverse events diagnosed within three days of vaccine administration in dogs.
abstract: OBJECTIVE
  To determine incidence rates and potential risk factors for vaccine-associated adverse events (VAAEs) diagnosed within 3 days of administration in dogs.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  1,226,159 dogs vaccinated at 360 veterinary hospitals.
  
  
  METHODS
  Electronic records from January 1, 2002, through December 31, 2003, were searched for possible VAAEs (nonspecific vaccine reaction, allergic reaction, urticaria, or anaphylaxis) diagnosed within 3 days of vaccine administration. Information included age, weight, sex, neuter status, and breed. Specific clinical signs and treatments were reviewed in a random sample of 400 affected dogs. The association between potential risk factors and a VAAE was estimated by use of multivariate logistic regression.
  
  
  RESULTS
  4,678 adverse events (38.2/10,000 dogs vaccinated) were associated with administration of 3,439,576 doses of vaccine to 1,226,159 dogs. The VAAE rate decreased significantly as body weight increased. Risk was 27% to 38% greater for neutered versus sexually intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years old versus 2 to 9 months old. The risk of a VAAE significantly increased as the number of vaccine doses administered per office visit increased; each additional vaccine significantly increased risk of an adverse event by 27% in dogs < or = 10 kg (22 lb) and 12% in dogs > 10 kg.
  
  
  CONCLUSIONS
  Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination. These factors should be considered in risk assessment and risk communication with clients regarding vaccination.
authors.affiliation: Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-2027, USA.
authors.forename: George E
authors.initials: GE
authors.lastname: Moore
authors.forename: Lynn F
authors.initials: LF
authors.lastname: Guptill
authors.forename: Michael P
authors.initials: MP
authors.lastname: Ward
authors.forename: Nita W
authors.initials: NW
authors.lastname: Glickman
authors.forename: Karen K
authors.initials: KK
authors.lastname: Faunt
authors.forename: Hugh B
authors.initials: HB
authors.lastname: Lewis
authors.forename: Lawrence T
authors.initials: LT
authors.lastname: Glickman
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D002369:Castration / Q000009:adverse effects / Q000662:veterinary; D015331:Cohort Studies; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control; D004285:Dogs / Q000276:immunology*; D005260:Female; D015994:Incidence; D008297:Male; D015999:Multivariate Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary*