title: [Granular cell tumor -- a rare tumor lesion of submandibular gland origin].
abstract: BACKGROUND
  Granular cell tumors are rare entities with manifestations in nearly all organ systems. Appearance in salivary glands is observed in singular cases.
  
  
  METHODS
  We report a 54 years old female patient with a painless submandibular tumor lesion. Using a submandibular approach the tumor was totally removed with the submandibular gland. Histologically a benign granular cell tumor was diagnosed. The immunohistological examination revealed positive for S-100 antigen and vimentin, negative for KL1 antigen. The clinical follow-up for about 3 years was without complications or tumor recidive.
  
  
  CONCLUSIONS
  A differential diagnosis of a submandibular mass is the rare manifestation of a benign granular cell tumor. The neurogen origin can be proven immunohistologically by positive S-100 antigen detection. The complete surgical resection is the therapy of choice.
authors.affiliation: Klinik für HNO-Heilkunde, Kopf- und Halschirurgie. christian_sartorius@web.de
authors.forename: C
authors.initials: C
authors.lastname: Sartorius
authors.forename: B
authors.initials: B
authors.lastname: Plechata
authors.forename: W
authors.initials: W
authors.lastname: Luis
authors.forename: H G
authors.initials: HG
authors.lastname: Kempf
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D016586:Granular Cell Tumor / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D013363:Submandibular Gland / Q000473:pathology / Q000601:surgery; D013365:Submandibular Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins; D014746:Vimentin