Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk.
Several case-control studies performed in populations where the incidence of tuberculosis (TB) is high have examined genetic susceptibility to TB. The Vitamin D receptor (VDR) gene is a good candidate, because it influences immune response, and associations between TaqI and FokI polymorphisms in the VDR gene and pulmonary TB risk have been found. Furthermore, if a relationship between these polymorphisms and TB risk is confirmed this will be important evidence pointing to vitamin D as a potential preventive agent for TB. We carried out a systematic review and meta-analysis, and found that results were inconclusive and studies were underpowered.
Lewis
S J
SJ
Department of Social Medicine, University of Bristol, Bristol, United Kingdom. s.j.lewis@bristol.ac.uk
Baker
I
I
Davey Smith
G
G
D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
D018167:Receptors, Calcitriol