title: Enzymatic removal of carboxyl protecting groups. 2. Cleavage of the benzyl and methyl moieties.
abstract: [reaction: see text] Enzymes are versatile reagents for the efficient removal of methyl and benzyl protecting groups. An esterase from Bacillus subtilis (BS2) and a lipase from Candida antarctica (CAL-A) allow a mild and selective removal of these moieties in high yields without affecting other functional groups.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Greece.
authors.forename: Efrosini
authors.initials: E
authors.lastname: Barbayianni
authors.forename: Irene
authors.initials: I
authors.lastname: Fotakopoulou
authors.forename: Marlen
authors.initials: M
authors.lastname: Schmidt
authors.forename: Violetta
authors.initials: V
authors.lastname: Constantinou-Kokotou
authors.forename: Uwe T
authors.initials: UT
authors.lastname: Bornscheuer
authors.forename: George
authors.initials: G
authors.lastname: Kokotos
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology; D001554:Benzene / Q000737:chemistry*; D002175:Candida / Q000201:enzymology; D004952:Esters / Q000737:chemistry; D006868:Hydrolysis; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D008745:Methylation; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D010741:Phospholipases A / Q000037:antagonists & inhibitors
chemical_list: D004952:Esters; D010455:Peptides; D008049:Lipase; D010741:Phospholipases A; D010196:Pancreatic Elastase; D001554:Benzene