title: Association between hemodynamic profile during laboratory stress and ambulatory pulse pressure.
abstract: Hemodynamic responses underlying blood pressure reactivity to laboratory stress are theoretically linked to cardiovascular pathophysiology. The present study investigated whether a vascular response predicted ambulatory pulse pressure, a known risk factor for cardiovascular disease. A new model of hemodynamic profile, previously developed by the authors, was applied to 24-h ambulatory data from 30 female and 34 male healthy young adults. Of these, 40 were monitored during a naturalistic stressor (university examination). For females, hemodynamic profile significantly predicted nighttime systolic blood pressure, and 24-h, day-, and nighttime diastolic blood pressure, but not ambulatory pulse pressure. A vascular or mixed hemodynamic profile significantly predicted 24-h and daytime ambulatory pulse pressure in males. The findings are consistent with theories of pathogenic mechanisms involving vascular changes and suggest that, for males, a vascular or mixed hemodynamic profile measured during laboratory stress may be a risk marker for cardiovascular disease, by its association with ambulatory pulse pressure.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Victoria, Australia. elizabeth.douglas@med.monash.edu.au
authors.forename: M Elizabeth Douglas
authors.initials: ME
authors.lastname: Gregg
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Matyas
authors.forename: Jack E
authors.initials: JE
authors.lastname: James
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005080:Exercise Test / Q000523:psychology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D012737:Sex Factors; D013315:Stress, Psychological / Q000503:physiopathology*