title: Acral necrotizing mycosis fungoides.
abstract: A 65-year-old male with long-standing acral "eczema" and patches of mycosis fungoides suddenly developed a transformed, necrotizing ulcerative cutaneous T-cell lymphoma manifesting as necrotic lesions of the toe and lip. The tumor had brown and/or black eschars on the surface and grew multiple opportunistic organisms. Markers CD3, Epstein-Barr virus-encoded small RNA, and T-cell receptor g gene rearrangement were positive, with CD4, 8, 30, 56, and TIA-1 negative. In spite of initial response to radiation, the patient succumbed to infection within 3 months.
authors.affiliation: Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Tasneem
authors.initials: T
authors.lastname: Poonawalla
authors.forename: Dan
authors.initials: D
authors.lastname: Jones
authors.forename: Fredrick
authors.initials: F
authors.lastname: Hagemeister
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008048:Lip Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy; D009336:Necrosis / Q000150:complications / Q000473:pathology / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy