[Central fat deposits contribute to atherosclerosis and insulin resistance and peripheral fat deposits protect against atherosclerosis and insulin resistance in postmenopausal women--secondary publication].
An analysis of 290 postmenopausal women, subdivided into four distinct body fat distribution groups, showed that peripheral fat mass (PFM) confers insulin-sensitizing and anti-atherogenic effects. PFM contributes to circulating adiponectin, an adipocyte-derived hormone with insulin-sensitizing, anti-inflammatory, and anti-atherogenic effects. In generally obese women, the secretion of adiponectin by PFM provides effective anti-atherogenic protection. In postmenopausal women, body fat distribution has more critical implications for metabolic and cardiovascular risk than overall obesity per se.
Tanko
Laszlo B
LB
Center for Clinical and Basic Research, Ballerup. lbt@ccbr.dk
Richelsen
Bjørn
B
Larsen
Philip J
PJ
D015502:Absorptiometry, Photon; D052242:Adiponectin; D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000378:metabolism; D000886:Anthropometry; D001012:Aorta, Abdominal / Q000473:pathology; D001018:Aortic Diseases / Q000209:etiology; D001161:Arteriosclerosis / Q000209:etiology*; D001823:Body Composition; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D010641:Phenotype; D017698:Postmenopause; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D052242:Adiponectin; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D012738:Sex Hormone-Binding Globulin; D004958:Estradiol