title: Large cell neuroendocrine carcinoma of the uterine cervix with cytogenetic analysis by comparative genomic hybridization: a case study.
abstract: Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a newly introduced category of the revised World Health Organization classification. We reported a case of cervical LCNEC with cytogenetic analysis by comparative genomic hybridization (CGH). The cervical tumor showed moderately increased mitotic activity (8-14 mitotic figures per 10 high-power fields) and focal necrosis, which made it problematic to differentiate from atypical carcinoid. CGH analysis failed to detect chromosome 11q loss that has been reported to be characteristic of pulmonary atypical carcinoids. Furthermore, chromosome 3q amplification, which has been detected frequently in pulmonary small cell carcinomas and LCNECs but not in pulmonary typical and atypical carcinoids, was the most remarkable chromosomal aberration. Although CGH reports are extremely rare in neuroendocrine tumors of the uterine cervix, specific chromosomal aberrations may be useful in their distinction.
authors.affiliation: Department of Pathology, Yamaguchi University School of Medicine, Yamaguchi 755-8505, Japan. shig@yamaguchi-u.ac.jp
authors.forename: Shigeto
authors.initials: S
authors.lastname: Kawauchi
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Okuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Morioka
authors.forename: Fumio
authors.initials: F
authors.lastname: Iwasaki
authors.forename: Fujimi
authors.initials: F
authors.lastname: Fukuma
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Chochi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Furuya
authors.forename: Atsunori
authors.initials: A
authors.lastname: Oga
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D002276:Carcinoid Tumor / Q000175:diagnosis; D018287:Carcinoma, Large Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology*; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3; D020732:Cytogenetic Analysis; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008938:Mitosis; D010052:Ovariectomy; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D014626:Vaginal Smears
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D004273:DNA, Neoplasm; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase