title: A bead-alignment device with a bead-sized microchamber on a rotating cylinder for fabrication of a miniaturized probe array.
abstract: We have developed a compact bead-alignment device with a bead-sized microchamber on a rotating cylinder. The cylinder fits inside a tube with bead-stock pipes containing different probe-conjugated beads and holes for bead-alignment capillaries. The cylinder rotates in the tube, and the microchamber transfers a single 100-microm-diameter bead from a pipe to one of the capillaries in 10 s. By using this process repeatedly, 'bead arrays', which are miniaturized DNA probe arrays in capillaries, were successfully fabricated.
authors.affiliation: Hitachi, Ltd., Central Research Laboratory 1-280 Higashi-Koigakubo, Kokubunji, Tokyo 185-8601, Japan. noda-h@crl.hitachi.co.jp
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Noda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kaise
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kohara
authors.forename: Kazunori
authors.initials: K
authors.lastname: Okano
authors.forename: Hideki
authors.initials: H
authors.lastname: Kambara