[Haemostatic and fibrinolytic variables in women with anorexia nervosa].
OBJECTIVE
The aim of this study was to evaluate haemostatic variables in women with anorexia nervosa --AN.


METHODS
23 obese female patients, and 39 female anorexic patients diagnosed acc. to DSM-IV and ICD-10 criteria were recruited. The studied group was compared to a control group--37 healthy female volunteers. BMI was calculated for AN, obese, and the control group. The following measurements were taken: prothrombin index, prothrombin time, thrombin time, fibrinogen, factor VII, ATIII, D-dimers, INR, APTT, protein C and PAI-1 activity, t-PA activity, PAI-1 antigen, t-PA antigen, glucose level, insulin level, E2 and total fat.


RESULTS
In the AN group the INR, prothrombin time, PAI-1 activity, t-PA activity, protein C level were increased, whereas PAI-1 antigen, t-PA antigen, prothrombin index, fasting insulin level and fasting glucose level were decreased.


CONCLUSIONS
We conclude that, in the AN group, an impaired fibrinolysis and coagulation are observed and there is a correlation between fibrinolytic and coagulation parameters and carbohydrate metabolism.
Sobieszczańska
Sylwia
S
Klinika Zaburzeń Afektywnych i Psychiatrii Młodziezowej, Katedry Psychiatrii UM w Lodzi.
Rabe-Jabłońska
Jolanta
J
D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D000990:Antithrombin III / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001824:Body Constitution; D015992:Body Mass Index; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000097:blood*; D010960:Plasminogen Activators / Q000097:blood; D015849:Plasminogen Inactivators / Q000097:blood; D011486:Protein C / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000097:blood
D001779:Blood Coagulation Factors; D001786:Blood Glucose; D007328:Insulin; D015849:Plasminogen Inactivators; D011486:Protein C; D000990:Antithrombin III; D005169:Factor VIII; D005340:Fibrinogen; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator