title: [Prevalence and risk factors for bacteriuria in patients with cirrhosis].
abstract: Bacterial infections occur frequently in patients with cirrhosis and may worsen the disease outcome. We investigated the prevalence of bacteriuria in 500 consecutive patients with cirrhosis, in different Child-Pugh stages (41.4% A; 40.8% B; 17% C) and analysed the associated risk factors. Most of the cirrhosis cases were virus related; alcohol abuse was recorded in 6.2% of the patients. Bacteriuria was detected in 139 (27.8%) cases: 32.4% were more than 100,000 cfu/ml; 7.9% between 100,000 and 1.000,000 cfu/ml and the remaining cases more than 1000,000 cfu/ml. Escherichia coli was the most frequent isolated agent (84.5%); Proteus spp. strains were detected only in bacteriuria with more than 100,000 cfu/ml. At univariate analysis, female gender, age and presence of diabetes were significantly associated to bacteriuria, while Child-Pugh stage and the presence of hepatocellular carcinoma were not. In a multivariate model, only female gender and diabetes were significantly associated to bacteriuria. These results indicate that advanced cirrhosis was not a risk for bacteriuria, that was associated rather to gender and diabetes, which are common risk factors for bacteriuria in non-cirrhotic patients.
authors.affiliation: Divisione Epatiti Virali Acute e Croniche, Dipartimento di Malattie Infettive, Seconda Universita di Napoli, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Amato
authors.forename: Davide Ferdinando
authors.initials: DF
authors.lastname: Precone
authors.forename: Novella
authors.initials: N
authors.lastname: Carannante
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Brancaccio
authors.forename: Gianfranca
authors.initials: G
authors.lastname: Stornaiuolo
authors.forename: Domenico
authors.initials: D
authors.lastname: Galante
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Gaeta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001437:Bacteriuria / Q000150:complications / Q000453:epidemiology*; D015897:Comorbidity; D048909:Diabetes Complications / Q000453:epidemiology; D004198:Disease Susceptibility; D004927:Escherichia coli Infections / Q000150:complications / Q000453:epidemiology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology; D006801:Humans; D016867:Immunocompromised Host; D008103:Liver Cirrhosis / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011512:Proteus Infections / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors