Alternative splicing--when two's a crowd.
Various mechanisms have been proposed to explain mutually exclusive splicing of pairs of exons. A paper in this issue of Cell (Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.
Smith
Christopher W J
CW
Department of Biochemistry, Cambridge, UK.
D000818:Animals; D006801:Humans; D017398:Alternative Splicing / Q000235:genetics; D015815:Cell Adhesion Molecules; D004331:Drosophila melanogaster / Q000235:genetics; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics; D005091:Exons / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D022821:RNA Splice Sites / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017381:Spliceosomes / Q000235:genetics
D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; C491736:Dscam1 protein, Drosophila; D022821:RNA Splice Sites; D012333:RNA, Messenger