A case of monophasic synovial sarcoma presenting as a vulvar mass.
BACKGROUND
Synovial sarcoma is the fourth most commonly occurring sarcoma, accounting for 8-10% of all sarcomas. They arise from unknown pleuripotent stem cells that are capable of differentiating into mesenchymal and/or epithelial structures. Synovial sarcoma is characterized by specific chromosomal translocation t (X; 18)(p11, q11).


METHODS
We report the first case of monophasic synovial sarcoma arising in soft tissues of the vulva in a 33-year-old female. Complete excision of the mass was possible with tumor-free margins.


CONCLUSIONS
Only four previous cases of biphasic synovial sarcoma arising in the vulva have been reported. The finding of the SYT-SSX2 translocation is generally associated with a better prognosis, besides tumor negative margins after excision offer the possibility of a better outlook for this patient.
Ambani
Dipika S
DS
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA. dambani@bcm.tmc.edu
White
Beverly
B
Kaplan
Alan L
AL
Alberto
Ayala
A
D000328:Adult; D005260:Female; D006801:Humans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014846:Vulvar Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery