[Current concepts of the physiopathology of coronary beta-adrenergic receptors, and their clinical applications].
Beta-adrenergic vasodilation plays a key role in the regulation of coronary blood flow, in particular during sympathetic nervous system activation. Beta1-adrenergic receptors are mostly represented in epicardial coronary vessel, while beta2 receptors are located in microvasculature. Coronary atherosclerosis is associated with a significant impairment of beta-adrenergic receptor response. This might contribute to precipitate myocardial ischemia.
Barbato
Emanuele
E
Cattedra di Cardiologia, Università Federico II, Napoli. barba22@hotmail.com
Wijns
William
W
De Bruyne
Bernard
B
Mascia
Giuseppe
G
Piscione
Federico
F
D000318:Adrenergic beta-Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000378:metabolism*; D003326:Coronary Circulation; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D018342:Receptors, Adrenergic, beta-1 / Q000378:metabolism; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2