title: High average daily intake of PCDD/Fs and serum levels in residents living near a deserted factory producing pentachlorophenol (PCP) in Taiwan: influence of contaminated fish consumption.
abstract: An abandoned pentachlorophenol plant and nearby area in southern Taiwan was heavily contaminated by dioxins, impurities formed in the PCP production process. The investigation showed that the average serum PCDD/Fs of residents living nearby area (62.5 pg WHO-TEQ/g lipid) was higher than those living in the non-polluted area (22.5 and 18.2 pg WHO-TEQ/g lipid) (P<0.05). In biota samples, average PCDD/F of milkfish in sea reservoir (28.3 pg WHO-TEQ/g) was higher than those in the nearby fish farm (0.15 pg WHO-TEQ/g), and Tilapia and shrimp showed the similar trend. The average daily PCDD/Fs intake of 38% participants was higher than 4 pg WHO-TEQ/kg/day suggested by the world health organization. Serum PCDD/F was positively associated with average daily intake (ADI) after adjustment for age, sex, BMI, and smoking status. In addition, a prospective cohort study is suggested to determine the long-term health effects on the people living near factory.
authors.affiliation: Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan.
authors.forename: C C
authors.initials: CC
authors.lastname: Lee
authors.forename: W T
authors.initials: WT
authors.lastname: Lin
authors.forename: P C
authors.initials: PC
authors.lastname: Liao
authors.forename: H J
authors.initials: HJ
authors.lastname: Su
authors.forename: H L
authors.initials: HL
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000822:Animal Husbandry; D000818:Animals; D001572:Benzofurans / Q000008:administration & dosage / Q000097:blood*; D002617:Chemical Industry; D000072338:Dibenzofurans, Polychlorinated; D004435:Eating; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity; D005260:Female; D005399:Fishes; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009792:Oceans and Seas; D010416:Pentachlorophenol / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D013624:Taiwan; D017210:Tilapia; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity
chemical_list: D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D014874:Water Pollutants, Chemical; D010416:Pentachlorophenol