title: Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report.
abstract: OBJECTIVE
  Longitudinal changes in plasma beta amyloid protein 1-42 and 1-40 (Abeta42 and Abeta40) levels and possible relationships with cognitive decline and apolipoprotein (APOE) genotype were studied in healthy elderly individuals.
  
  
  METHODS
  Authors determined cognitive level and plasma Abeta40 and Abeta42 levels twice, approximately 4 years apart, in 34 elderly subjects.
  
  
  RESULTS
  Analyses revealed a selective reduction in Abeta42 levels at follow-up, which were not modulated by the epsilon4 allele. Greater reductions and higher baseline plasma Abeta42 levels were associated with reductions in cognitive scores.
  
  
  CONCLUSIONS
  Alterations in plasma Abeta42 levels may be associated with subtle cognitive decline in elderly subjects without dementia.
authors.affiliation: Geriatric Psychiatry Program, Nathan S. Kline Institute, 140 Old Orangeburg Rd., Bldg. 35, Orangeburg, NY 10962, USA. pomara@nki.rfmh.org
authors.forename: Nunzio
authors.initials: N
authors.lastname: Pomara
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Willoughby
authors.forename: John J
authors.initials: JJ
authors.lastname: Sidtis
authors.forename: Pankaj D
authors.initials: PD
authors.lastname: Mehta
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000097:blood*; D001057:Apolipoproteins E / Q000235:genetics; D003072:Cognition Disorders / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E