Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy.
The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.
Lin
J J
JJ
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. linjj@uci.edu
Salamon
N
N
Dutton
R A
RA
Lee
A D
AD
Geaga
J A
JA
Hayashi
K M
KM
Toga
A W
AW
Engel
J
J
Thompson
P M
PM
D000328:Adult; D001284:Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional; D007407:Interviews as Topic; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D019635:Neurosurgical Procedures; D018579:Patient Selection; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*