title: Angiotensinogen and plasminogen activator inhibitor-1 gene polymorphism in relation to renovascular disease.
abstract: The present study was designed to evaluate angiotensinogen (AGT) M235T and plasminogen activator inhibitor-1 (PAI-1) (4G/5G) polymorphisims in relation to the occurrence of atherosclerotic renal artery stenosis (ARAS) and recurrent stenosis. In this study, 30 patients were enrolled after angiographic demonstration of ARAS; 100 healthy subjects for AGT polymorphism and 80 healthy subjects for PAI-1 polymorphism were considered the control group. The patients were followed for a mean 46.1 +/- 9.2 months. The patients had significantly higher frequencies of the MT genotype and the T allele than control group (chi(2) = 18.2, p < 0.001 and chi(2) = 11.5 p < 0.001). There were no significant differences in the PAI-1 genotype and allele findings when the data for all patients were compared with that for the controls (chi(2)= 2.45, p = 0.29 and chi(2) = 0.019, p = 0.89). There were no significant differences in the genotype and allele findings for the patients with and without restenosis (p > 0.05). The C-reactive protein (CRP) level was higher in the patients with restenosis than in the patients without restenosis (7.694 +/- 0.39 mg/L and 1.56 +/- 1.08 mg/L) (p = 0.001). Our results suggest that the M235T MT genotype and T allele might be associated with increased risk of atherosclerotic renal artery stenosis. The CRP level might be an independent predictor for recurrent stenosis.
authors.affiliation: Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey. akadriyer@hotmail.com
authors.forename: Kadriye Altok
authors.initials: KA
authors.lastname: Reis
authors.forename: Baran
authors.initials: B
authors.lastname: Onal
authors.forename: Sevim
authors.initials: S
authors.lastname: Gonen
authors.forename: Turgay
authors.initials: T
authors.lastname: Arinsoy
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Erten
authors.forename: Erhan
authors.initials: E
authors.lastname: Ilgit
authors.forename: Oguz
authors.initials: O
authors.lastname: Soylemezoglu
authors.forename: Ulver
authors.initials: U
authors.lastname: Derici
authors.forename: Galip
authors.initials: G
authors.lastname: Guz
authors.forename: Musa
authors.initials: M
authors.lastname: Bali
authors.forename: Sukru
authors.initials: S
authors.lastname: Sindel
mesh_terms: D000483:Alleles; D000792:Angiography; D000808:Angiotensinogen / Q000235:genetics*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012008:Recurrence; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000235:genetics*; D018709:Statistics, Nonparametric
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D000808:Angiotensinogen