Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A.
Four differently substituted trimers of the CPS repeating unit have been synthesised in order to investigate the dependence on oligosaccharide size, acetylation and mode of phosphorylation of glycoconjugate vaccines against Neisseria meningitidis group A. A spacer-containing starting monomer, a H-phosphonate elongating monomer and a 6-O-phosphorylated H-phosphonate cap monomer have been synthesised and coupled together to afford, after deprotection, the target trimer structures differing in their acetylation and phosphorylation substitution pattern.
Slättegård
Rikard
R
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden.
Teodorovic
Peter
P
Kinfe
Henok Hadgu
HH
Ravenscroft
Neil
N
Gammon
David W
DW
Oscarson
Stefan
S
D016667:Bacterial Capsules / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D038381:Neisseria meningitidis, Serogroup A / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
D011135:Polysaccharides, Bacterial