title: Microbial glycosylation and acetylation of brefeldin A.
abstract: The brefeldin A (BFA) derivatives 4-O-acetyl BFA, 7-O-acetyl BFA, and 4-O-D-glucosyl BFA were found by the microbial conversion of BFA. 4-O-D-Glucosyl BFA is a novel compound produced by the conversion of BFA with Streptomyces sp. Q53834. The cytotoxicity and antifungal activity of all of the compounds were markedly less than those of BFA.
authors.affiliation: Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. shibazak@yamanouchi.co.jp
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Shibazaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Takeo
authors.initials: T
authors.lastname: Sugawara
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamamoto