Beta-lactam resistance and Enterobacteriaceae, United States.
Extended-spectrum cephalosporins (ESC) are an important drug class for treating severe Salmonella infections. We screened the human collection from the National Antimicrobial Resistance Monitoring System 2000 for ESC resistance mechanisms. Of non-Typhi Salmonella tested, 3.2% (44/1,378) contained blaCMY genes. Novel findings included blaCMY-positive Escherichia coli O157:H7 and a blaSHV-positive Salmonella isolate. CMY-positive isolates showed a ceftriaxone MIC > or =2 microg/mL.
Whichard
Jean M
JM
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. zyr3@cdc.gov
Joyce
Kevin
K
Fey
Paul D
PD
Nelson
Jennifer M
JM
Angulo
Frederick J
FJ
Barrett
Timothy J
TJ
D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007525:Isoelectric Focusing / Q000379:methods; D008826:Microbial Sensitivity Tests; D014481:United States; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D002511:Cephalosporins; D001618:beta-Lactamases