title: Endocervical-like mucinous borderline tumors of the ovary: clinicopathological features and electron microscopic findings.
abstract: Endocervical-like mucinous borderline tumor (EMBT) is a distinct entity of the ovary that seems to be underrecognized. It occurs with relatively high frequency in Japanese women. Compared with intestinal-type mucinous borderline tumor (IMBT), more frequent bilateral occurrence, paucilocular cysts, association with endometriosis, absence of pseudomyxoma but possible association of peritoneal implants and lymph node metastases, and lower mortality rate are the characteristic features. Histologically, it consists of a mixture of two types of epithelium, tall columnar mucinous cells and stratified eosinophilic cells. Electron microscopy revealed that they were endocervical glandlike mucinous cells and ciliated columnar epithelium reminiscent of the fallopian tube. As the mixture of EMBT and serous borderline tumor (seromucinous borderline tumor) occurs, these findings may show that the tumor shows MUllerian origin with two-way differentiation, or differentiation toward endocervical glands with metaplastic features as seen in reactive endocervical lesions.
authors.affiliation: Department of Pathology, Tohoku University Hospital, Aoba-ku, Sendai 980-8574, Japan. moriya@patholo2.med.tohoku.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Moriya
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Mikami
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Mareyuki
authors.initials: M
authors.lastname: Endoh
authors.forename: Junji
authors.initials: J
authors.lastname: Takeyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shizue
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Mika
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Monobe
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D002277:Carcinoma / Q000145:classification / Q000473:pathology* / Q000556:secondary; D018282:Cystadenocarcinoma, Mucinous / Q000473:pathology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010051:Ovarian Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000473:pathology