Progressive toxemia with acetaldehyde in a reactive form of alcohol withdrawal syndrome.
We carried out a complex clinical and laboratory examination of 169 patients with reactive form of alcohol withdrawal syndrome. Progressive toxemia with acetaldehyde (key pathogenetic stage) and volemic changes were followed by homeostasis disorders and gradual decompensation of the natural detoxification system. The patients with this form of alcohol withdrawal syndrome did not exhibit physical and psychic dependence on alcohol. The proposed therapeutic algorithm for the treatment of various pathogenetic stages rapidly and efficiently restored homeostasis parameters and prevented the development of serious and life-threating complications.
Remennik
A G
AG
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Moscow.
Nepomnyashchikh
L M
LM
Remennik
V I
VI
D000079:Acetaldehyde / Q000627:therapeutic use* / Q000633:toxicity*; D003422:Critical Care; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D020896:Hypovolemia / Q000209:etiology / Q000628:therapy; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D014115:Toxemia / Q000139:chemically induced*
D000431:Ethanol; D000079:Acetaldehyde