title: A mathematical model of the response of semicircular canal and otolith to head rotation under gravity.
abstract: The mathematical model of the system composed of two sensors: semicircular canal and sacculus, is presented. The system is described by three series of blocks: biomechanical block, mechanoelectrical transduction mechanism and hair cell ionic currents and membrane potential dynamics. The response of the aforecited system to various stimuli (head rotation under gravity and falling) was investigated. The identification of the model parameters was fulfilled for the experimental data, obtained for the axolotle (Ambystoma tigrinum) in Institute of Physiology, Autonomous University of Puebla, Mexico. The comparative analysis of canal and sacculus membrane potential was realized.
authors.affiliation: Faculty of Mechanics and Mathematics, Moscow State University, Russia. i_nelly@hotmail.com
authors.forename: V V
authors.initials: VV
authors.lastname: Alexandrov
authors.forename: T B
authors.initials: TB
authors.lastname: Alexandrova
authors.forename: T G
authors.initials: TG
authors.lastname: Astakhova
authors.forename: N V
authors.initials: NV
authors.lastname: Kulikovskaya
authors.forename: V I
authors.initials: VI
authors.lastname: Kurilov
authors.forename: S S
authors.initials: SS
authors.lastname: Migunov
authors.forename: N E
authors.initials: NE
authors.lastname: Shulenina
authors.forename: E
authors.initials: E
authors.lastname: Soto
authors.forename: R
authors.initials: R
authors.lastname: Vega
mesh_terms: D000054:Acceleration; D000557:Ambystoma; D000818:Animals; D001522:Behavior, Animal; D006198:Hair Cells, Auditory / Q000502:physiology*; D019416:Head Movements / Q000502:physiology; D008433:Mathematics; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D012399:Rotation; D012444:Saccule and Utricle / Q000502:physiology*; D012665:Semicircular Canals / Q000502:physiology*; D013550:Swimming; D014722:Vestibule, Labyrinth / Q000502:physiology