title: The marriage of glucose and blood vessels: it isn't all that sweet.
abstract: The secondary complications of diabetes are the major factors limiting quality of life and longevity in diabetic patients. Among these complications, cardiovascular disease is the major cause of morbidity and mortality. Based on a recent paper by Vikramadithyan et al. (2005), this preview addresses the role of aldose reductase as a contributor to the pathogenesis of diabetic macrovascular disease.
authors.affiliation: Institute of Molecular Medicine & Genomics, Medical College of Georgia, Augusta, Georgia 30912, USA.
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Xiong
authors.forename: David M
authors.initials: DM
authors.lastname: Stern
mesh_terms: D000449:Aldehyde Reductase / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001808:Blood Vessels / Q000201:enzymology*; D048909:Diabetes Complications / Q000201:enzymology* / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D051379:Mice; D014652:Vascular Diseases / Q000150:complications* / Q000201:enzymology / Q000378:metabolism*
chemical_list: D000449:Aldehyde Reductase; D005947:Glucose