title: Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development.
abstract: We isolated a new gene which shares all the features of the Ly-6/neurotoxin superfamily, from gene organization to predicted 3D structure. As it is preferentially expressed in the nervous system, we called this gene lynx2, by analogy with lynx1, a nAChR modulator. In embryonic and postnatal mouse, lynx2 is expressed in postmitotic central and peripheral neurons. These include subpopulations of motor neurons, sensory neurons, interneurons and neurons of the autonomous nervous system. In addition, lynx2 is transiently expressed around the growing nerves in the limb bud. Comparison of its spatio-temporal expression pattern with that of two other members of this family, lynx1 and ly-6h, shows that these genes are detected both in distinct and overlapping neuron populations.
authors.affiliation: INSERM UMR 623, Developmental Biology Institute of Marseille (INSERM, CNRS), Case 907, 13288 Marseille Cedex 09, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Dessaud
authors.forename: Danièle
authors.initials: D
authors.lastname: Salaün
authors.forename: Odile
authors.initials: O
authors.lastname: Gayet
authors.forename: Marie
authors.initials: M
authors.lastname: Chabbert
authors.forename: Odile
authors.initials: O
authors.lastname: deLapeyrière
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004622:Embryo, Mammalian / Q000033:anatomy & histology / Q000502:physiology*; D017403:In Situ Hybridization; D007381:Intermediate Filament Proteins / Q000235:genetics / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009479:Neuropeptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D064531:Peripherins; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D064531:Peripherins; C120222:Lynx1 protein, mouse; C510894:Lypd1 protein, mouse