title: Observations in a cohort of infants with severe laryngeal dyskinesia Auditory brainstem response may aid in the diagnosis.
abstract: OBJECTIVE
  Laryngeal dyskinesia is not a well defined clinical entity, and difficult to distinguish from some other laryngeal disorders. We report on the observations, especially auditory brainstem responses, in a series of infants with laryngeal dyskinesia.
  
  
  METHODS
  All infants with laryngeal dyskinesia, diagnosed in Sophia Children's Hospital between 1 January 2000 and 31 June 2003, were included in this retrospective case series study. Auditory brainstem responses were available in most infants. The respiratory, neurological and other symptoms, were recorded.
  
  
  RESULTS
  Nine infants were diagnosed with laryngeal dyskinesia. Eight demonstrated severely abnormal auditory brainstem responses (ABR), indicating brainstem dysfunction. Most infants also had serious respiratory, and/or neurological disorders.
  
  
  CONCLUSIONS
  It is hypothesized that laryngeal dyskinesia is a manifestation of a complex neurological disorder localized in the brainstem, comparable with brainstem dysgenesis syndrome. We suggest to use ABR in the diagnosis of unexplained laryngeal obstructive disorders to better define the pathology, and possibly the etiology of the disease.
authors.affiliation: Department of Otorhinolaryngology, Sophia Children's Hospital, Erasmus MC, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. l.j.hoeve@erasmusmc.nl
authors.forename: L J Hans
authors.initials: LJ
authors.lastname: Hoeve
authors.forename: André
authors.initials: A
authors.lastname: Goedegebure
authors.forename: Koen F M
authors.initials: KF
authors.lastname: Joosten
mesh_terms: D003680:Deglutition Disorders / Q000209:etiology; D020820:Dyskinesias / Q000175:diagnosis* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D007223:Infant; D007818:Laryngeal Diseases / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D009123:Muscle Hypotonia / Q000503:physiopathology*; D014140:Tracheotomy