Plasma antioxidant activity and chromosome aberrations in humans exposed to long-term low-dose gamma-irradiation.
Plasma antioxidant activity was evaluated in the lecithin-Fe(2+) model system and cytogenetic studies were carried out in 16 men. A relationship between elevated antioxidant activity of the plasma and increased level of chromatid aberrations and with percentage of aberrant cells was detected in the experimental group, but no correlation was found between antioxidant activity and the integral dose of gamma-irradiation and rate of its accumulation. An assumption was made about exhaustion of the buffer capacity of the antioxidant defense system resulting from long-term exposure to unidentified factors of technogenic nature increasing plasma antioxidant activity and level of chromosome aberrations. In subjects with high level of antioxidant defense, naturally low antioxidant activity and low percentage of chromatid aberrations were probably maintained.
Marusin
A V
AV
Institute of Medical Genetics, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Moscow. marussin@img.tsu.ru
Popova
N A
NA
Salyukov
V B
VB
Stepanov
V A
VA
Nazarenko
S A
SA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002478:Cells, Cultured; D002842:Chromatids / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000528:radiation effects*; D015331:Cohort Studies; D003078:Colchicine / Q000494:pharmacology; D020732:Cytogenetic Analysis; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000528:radiation effects*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D016273:Occupational Exposure; D010835:Phytohemagglutinins / Q000494:pharmacology; D011829:Radiation Dosage; D012426:Russia; D013997:Time Factors
D000975:Antioxidants; D008934:Mitogens; D010835:Phytohemagglutinins; D003078:Colchicine