The effect of highly active antiretroviral treatment on viral load and antiretroviral drug levels in breast milk.
Viral load and drug levels were measured in the plasma and breast milk of nine mothers treated with highly active antiretroviral therapy (HAART) and one woman treated only with zidovudine during delivery. In all HAART-treated women after delivery the viral load was less than 400 copies/ml in plasma and breast milk. Compared with the plasma concentration, the breast milk concentration was between 68 and 90% for nevirapine, 6 and 24% for nelfinavir and 90 and 540% for indinavir.
Colebunders
Robert
R
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Hodossy
Beata
B
Burger
David
D
Daems
Tania
T
Roelens
Kristien
K
Coppens
Marc
M
Van Bulck
Ben
B
Jacquemyn
Yves
Y
Van Wijngaerden
Eric
E
Fransen
Katrien
K
D000328:Adult; D019380:Anti-HIV Agents / Q000378:metabolism*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D019562:Viral Load
D019380:Anti-HIV Agents