[Phenotypic and functional analysis of T lymphocytes in cancer patients].
In preclinical tumor model and in human cancer, tumor antigen specific T lymphocytes play a key role in the control of tumor development. Nevertheless in numerous cases, the infiltrating tumor T cells do not seem to influence the clinical progression of the tumor. A better phenotypic and functional characterization of T cells in close contact with tumor associated with a comprehensive analysis of tumor evasion mechanism to the host response should lead to an optimization of cancer immunotherapy protocols.
Badoual
Cécile
C
INSERM U 255, Institut Biomédical des Cordeliers, Université Paris 5.
Vingert
Benoît
B
Agueznay
Nour
N
Adotevi
Olivier
O
Haicheur
Nacilla
N
Molina
Thierry
T
Bruneval
Patrick
P
Fridman
Wolf H
WH
Tartour
Eric
E
D015703:Antigens, CD / Q000276:immunology; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology*; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology*
D015703:Antigens, CD