title: KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.
abstract: OBJECTIVE
  To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.
  
  
  METHODS
  Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.
  
  
  RESULTS
  Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).
  
  
  CONCLUSIONS
  The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
authors.affiliation: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Inagaki
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kokudo
authors.forename: Qian
authors.initials: Q
authors.lastname: Guo
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Seyama
authors.forename: Munehiro
authors.initials: M
authors.lastname: Nakata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Keiji
authors.initials: K
authors.lastname: Sano
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D000941:Antigens / Q000378:metabolism*; D000951:Antigens, Neoplasm; D003138:Common Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000378:metabolism*
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins