Interactions of interleukin-1 with neurotrophic factors in the central nervous system: beneficial or detrimental?
Interleukin (IL)-1 is a multifunctional cytokine that plays a key role in mediating inflammation in the brain. Many different cell types in the brain express the IL-1 receptor and respond to this cytokine by activating cell-type-specific signaling pathways leading to distinct functional responses, which collectively comprise the inflammatory response in the brain. One key effect of IL-1 in the brain is the induction of trophic factor production by glial cells, which has traditionally been considered a neuroprotective response to injury or disease. However, recent studies have shown that nerve growth factor, which is regulated by IL-1, can induce neuronal survival or apoptosis via different receptors. This article examines the interaction of IL-1 with different trophic factors in the brain.
Friedman
Wilma J
WJ
Department of Biological Sciences, Rutgers University, Newark, NJ, USA. wilmaf@andromeda.rutgers.edu
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D015398:Signal Transduction
D018836:Inflammation Mediators; D007375:Interleukin-1; D009414:Nerve Growth Factors