title: [Expression of S100-labeled dendritic cells in glottic squamous cell carcinoma and its correlation to prognosis].
abstract: OBJECTIVE
  Dendritic cells (DCs) are the most important antigen-presenting cells, and can synthesize and secrete S100 protein. This study was designed to investigate the expression of S100-labeled DCs in glottic squamous cell carcinoma, and analyze its correlation to the prognosis.
  
  
  METHODS
  The expression of S100-labeled DCs in peritumoral tissues of 111 specimens of gllotic squamous cell carcinoma was detected by immunohistochemistry; 17 specimens of normal tissues were used as control. The correlation of S100-labeled DCs expression to prognosis of the 111 patients was evaluated.
  
  
  RESULTS
  The positive rates of S100-labeled DCs were 51.35% (57/111) in peritumoral tissues of gllotic squamous cell carcinoma, and 0 in normal tissues. The 5-year survival rate was significantly higher in S100-positive group than in S100-negative group (72.31% vs. 53.91%, P=0.030).
  
  
  CONCLUSIONS
  The glottic squamous cell carcinoma patients with obvious infiltration of S100-labeled DCs may achieve good prognosis.
authors.affiliation: Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P. R. China. chenwenkuan@163.com
authors.forename: Wen-Kuan
authors.initials: WK
authors.lastname: Chen
authors.forename: Fu-Jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Zong-Yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Guo-Hao
authors.initials: GH
authors.lastname: Wu
authors.forename: Zhu-Ming
authors.initials: ZM
authors.lastname: Guo
authors.forename: Mao-Wen
authors.initials: MW
authors.lastname: Wei
authors.forename: An-Kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jie-Hua
authors.initials: JH
authors.lastname: He
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D005931:Glottis; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D009418:S100 Proteins