title: Expression of HBsAg and HBcAg in the ovaries and ova of patients with chronic hepatitis B.
abstract: OBJECTIVE
  To investigate the expression and distribution of HBV in the ovaries and ova.
  
  
  METHODS
  The immunohistochemistry method was used to detect the HBsAg and HBcAg in the ovaries of patients with chronic hepatitis B.
  
  
  RESULTS
  Expression of HBsAg in the ova, granular and interstitial cells of the ovaries was located in the cytomembrane and cytoplasm. Expression of HBcAg in the ova, granular, interstitial and endothelial cells of interstitial blood vessels of the ovaries was found in the cytomembrane, cytoplasm, and nuclei.
  
  
  CONCLUSIONS
  HBV can infect the ova at different stages of development and replicate in it.
authors.affiliation: Department of Infectious Disease, First Hospital of Xi'an Jiaotong University, Jiankang Road 1#, Xi'an 710061, Shaanxi Province, China. yefeng.jiaotong@163.com
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Ya-Fei
authors.initials: YF
authors.lastname: Yue
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Tian-Yan
authors.initials: TY
authors.lastname: Chen
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Zhang
authors.forename: Gui-Qin
authors.initials: GQ
authors.lastname: Bai
authors.forename: Min
authors.initials: M
authors.lastname: Liu
mesh_terms: D005260:Female; D015967:Gene Expression Regulation, Viral; D006512:Hepatitis B Core Antigens / Q000235:genetics / Q000378:metabolism*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000378:metabolism*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D010053:Ovary / Q000166:cytology / Q000821:virology*; D010063:Ovum / Q000166:cytology / Q000821:virology*
chemical_list: D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens