Vascular healing after stenting: the role of 17-beta-estradiol in improving re-endothelialization and reducing restenosis.
The predominant role of the endothelium in vascular healing after balloon injury and stent implantation is better recognized. The endothelium regulates vascular tone, thrombosis, inflammation and cell proliferation. It may be important to favour endothelial recovery after percutaneous coronary intervention (PCI) to reduce restenosis and improve clinical outcome. The present article reviews the scientific rationale, experimental data and early clinical results of 17-beta-estradiol and its role in the acceleration of endothelial recovery in vivo after PCI.
Tanguay
Jean-François
JF
Institut de Cardiologie de Montréal, Research Centre, Montreal Heart Institute, Department of Medicine, Québec. Jean-françois.tanguay@icm-mhi.org
D000818:Animals; D019917:Blood Vessel Prosthesis Implantation / Q000639:trends; D002986:Clinical Trials as Topic; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology / Q000601:surgery; D004958:Estradiol / Q000627:therapeutic use; D006083:Graft Occlusion, Vascular / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D015607:Stents / Q000639:trends; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D004958:Estradiol