ERG and anatomical abnormalities suggesting retinopathy in dementia with Lewy bodies.
The authors used flash electroretinography to demonstrate dysfunction of the photopic and scotopic retina in patients with dementia with Lewy bodies and visual hallucinations (VHs) compared with patients with Parkinson disease, patients without VHs, and controls. The retinal dysfunction may be related to slight alteration of the photoreceptors and numerous pale inclusions in the outer plexiform layer found at the post mortem examination, suggesting a specific retinopathy.
Devos
D
D
Service de Neurologie et Pathologie du Mouvement, EA2683, MENRT, Centre Hospitalier Universitaire de Lille, France. d-devos@chru-lille.fr
Tir
M
M
Maurage
C A
CA
Waucquier
N
N
Defebvre
L
L
Defoort-Dhellemmes
S
S
Destée
A
A
D000368:Aged; D004596:Electroretinography; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology / Q000648:ultrastructure; D020961:Lewy Body Disease / Q000150:complications*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010775:Photic Stimulation; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology / Q000648:ultrastructure; D011237:Predictive Value of Tests; D012160:Retina / Q000473:pathology* / Q000503:physiopathology*; D012164:Retinal Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000473:pathology / Q000648:ultrastructure