title: Pd-catalyzed silicon hydride reductions of aromatic and aliphatic nitro groups.
abstract: [reaction: see text] Room-temperature reduction of aromatic nitro groups to amines can be accomplished in high yield, with wide functional group tolerance and short reaction times (30 min) using a combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS). Replacing PMHS/KF with triethylsilane allows aliphatic nitro groups to be reduced to their hydroxylamines.
authors.affiliation: Department of Chemistry, Michigan State University, East Lansing, 48824, USA.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Rahaim
authors.forename: Robert E
authors.initials: RE
authors.lastname: Maleczka
mesh_terms: D002384:Catalysis; D006838:Hydrocarbons / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*
chemical_list: D006838:Hydrocarbons; D006841:Hydrocarbons, Aromatic; D009574:Nitro Compounds; D012821:Silanes; D012833:Siloxanes; C402373:poly(methylhydrosiloxane); C512918:triethylsilane; D010165:Palladium