[Dilated cardiomyopathy as a side effect of treatment with infliximab].
We report a case of heart failure after infusion of Remicade (infliximab) in a patient without heart insufficiency. The patient, a 25-year-old woman with inflammatory bowel disease, developed new-onset heart failure after receiving TNF antagonist therapy. After the treatment was discontinued and heart failure therapy was started, the patient improved significantly. The U.S. Food and Drug Administration has published 47 case reports of heart failure after therapy with a tumor necrosis factor antagonist, where 38 patients developed new-onset heart failure and 9 patients experienced heart failure exacerbation. There are no published reports of heart failure after TNF antagonist therapy in the Danish literature.
Leetmaa
Tina H
TH
Fredericia Sygehus, Medicinsk Afdeling. busybee@get2net.dk
Markenvard
John D
JD
D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006333:Heart Failure / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D000069285:Infliximab; D014463:Ultrasonography
D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab