Spinal cord injury: a model of central neuropathic pain.
The condition of pain after spinal cord injury (SCI) affects the life quality of nearly 70% of individuals with SCI. Clinical studies over the past decade have provided important insights into the complexities of the clinical and psychosocial characteristics of this debilitating consequence of SCI. The use of experimental models developed to study at-level or below-level pain has provided an appreciation for the mechanism(s) responsible for the onset and progression of these conditions. Important to the studies related to SCI pain has been the focus on the molecular, biochemical, anatomical, and functional consequences of SCI that have identified potential therapeutic targets for the design of novel treatment strategies.
Yezierski
Robert P
RP
Comprehensive Center for Pain Research and the McKnight Brain Institute University of Florida, Gainesville, FL 32610, USA. ryezierski@dental.ufl.edu
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D010146:Pain / Q000209:etiology*; D017288:Pain Threshold / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013119:Spinal Cord Injuries / Q000150:complications* / Q000378:metabolism / Q000473:pathology