title: A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists.
abstract: Enantiomerically pure (R)-2-chloro-1-(pyridin-3-yl)ethanol has been prepared by kinetic resolution performed in the presence of Candida antarctica SP435-L lipase immobilized on a macroporous polyacrylate resin (Novozym 435). It was converted into (R)-1-(pyridin-3-yl)-2-aminoethanol, left-hand side of beta(3)-adrenergic receptor ligands.
authors.affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Perrone
authors.forename: Ernesto
authors.initials: E
authors.lastname: Santandrea
authors.forename: Erika
authors.initials: E
authors.lastname: Giorgio
authors.forename: Laura
authors.initials: L
authors.lastname: Bleve
authors.forename: Antonio
authors.initials: A
authors.lastname: Scilimati
authors.forename: Paolo
authors.initials: P
authors.lastname: Tortorella
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D002175:Candida / Q000201:enzymology; D004800:Enzymes, Immobilized / Q000378:metabolism; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D008958:Models, Molecular; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D022702:Receptors, Adrenergic, beta-3 / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: C508669:(R)-1-(pyridin-3-yl)-2-aminoethanol; D058667:Adrenergic beta-3 Receptor Agonists; D004800:Enzymes, Immobilized; D004983:Ethanolamines; D011725:Pyridines; D022702:Receptors, Adrenergic, beta-3; D008049:Lipase