title: Avian flu: isolation of drug-resistant H5N1 virus.
abstract: The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
authors.affiliation: National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
authors.forename: Q Mai
authors.initials: QM
authors.lastname: Le
authors.forename: Maki
authors.initials: M
authors.lastname: Kiso
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Someya
authors.forename: Yuko T
authors.initials: YT
authors.lastname: Sakai
authors.forename: T Hien
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Khan H L
authors.initials: KH
authors.lastname: Nguyen
authors.forename: N Dinh
authors.initials: ND
authors.lastname: Pham
authors.forename: Ha H
authors.initials: HH
authors.lastname: Ngyen
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Muramoto
authors.forename: Taisuke
authors.initials: T
authors.lastname: Horimoto
authors.forename: Ayato
authors.initials: A
authors.lastname: Takada
authors.forename: Hideo
authors.initials: H
authors.lastname: Goto
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
mesh_terms: D000081:Acetamides / Q000008:administration & dosage* / Q000494:pharmacology / Q000600:supply & distribution / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D004252:DNA Mutational Analysis; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005289:Ferrets; D006146:Guanidines; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control / Q000635:transmission / Q000821:virology*; D020128:Inhibitory Concentration 50; D009154:Mutation / Q000235:genetics; D009439:Neuraminidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D053139:Oseltamivir; D016133:Polymerase Chain Reaction; D011714:Pyrans; D012794:Sialic Acids; D053243:Zanamivir
chemical_list: D000081:Acetamides; D006146:Guanidines; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D011714:Pyrans; D012794:Sialic Acids; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir