title: Rational design and synthesis of highly potent beta-glucocerebrosidase inhibitors.
authors.affiliation: Amicus Therapeutics Inc., Cranbury, NJ 08512, USA.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Zhu
authors.forename: Kamlesh A
authors.initials: KA
authors.lastname: Sheth
authors.forename: Shihong
authors.initials: S
authors.lastname: Li
authors.forename: Hui-Hwa
authors.initials: HH
authors.lastname: Chang
authors.forename: Jian-Qiang
authors.initials: JQ
authors.lastname: Fan
mesh_terms: D002236:Carbohydrate Conformation; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005962:Glucosylceramidase / Q000037:antagonists & inhibitors*; D050112:Imino Pyranoses / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D050112:Imino Pyranoses; D010880:Piperidines; C098432:isofagomine; D005962:Glucosylceramidase