title: Anatomy and physiology of the leptomeninges and CSF space.
abstract: The arachnoid membrane and pia mater are the two membranous layers that comprise the leptomeninges. Cerebrospinal fluid is made within the ventricular system by cells of the choroid plexus and ependyma. This chapter describes in detail the normal anatomic structure and physiologic interactions of the cerebrospinal fluid and leptomeningeal space that are critical to our understanding and treatment of leptomeningeal metastases.
authors.affiliation: The University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Barshes
authors.forename: Alexis
authors.initials: A
authors.lastname: Demopoulos
authors.forename: Herbert H
authors.initials: HH
authors.lastname: Engelhard
mesh_terms: D001099:Arachnoid / Q000033:anatomy & histology* / Q000502:physiology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000166:cytology* / Q000502:physiology*; D002831:Choroid Plexus / Q000033:anatomy & histology / Q000502:physiology; D004805:Ependyma / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D013116:Spinal Cord / Q000033:anatomy & histology / Q000502:physiology; D013346:Subarachnoid Space / Q000033:anatomy & histology* / Q000502:physiology*