title: [Current treatment of hepatocellular carcinoma. Analysis of a series of 123 cases over a 5-year period].
abstract: We analyze a 123-cases experience over a 5-year period in the treatment of hepatocellular carcinoma (HCC). Liver resection, transplantation and hyperthermic ablation of the tumor were used according to the indication and patient selection. Systemic chemotherapy followed resection in 18 cases and hyperthermic ablation in 5 cases. Chemo-embolisation was performed in patients to be transplanted and in other two patients with tumor destruction. A number of 86 liver resections were performed in 84 patients (2 re- resections in 1 patient, subsequently transplanted) - 43 on normal liver and 41 on cirrhotic liver. Postoperative mortality was 4.7% in non-cirrhotic and 4.9% in cirrhotic patients. Survival in non-cirrhotic patients was 77% at 1 year, 65% at 2 years, and constant - 45% at 3 and 4 years, whereas in cirrhotic patients it was 60%, 56%, 56% and 36% (Kaplan-Meyer actuarial survival rates). Nine patients underwent liver transplantation (4 OLTs, 3 living donor LT, 1 split LT and 1 "domino" LT); postoperative mortality was 11% (1 patient). At present five patients are alive and well. One patient died by peritoneal carcinomatosis at 10 months; another patient died at 6 months by severe cholestatic recurrent C virus hepatitis and one patient was discharged with permanent severe neurologic disturbances. In 31 patients hyperthermic ablation of the tumor was used with zero mortality. Actuarial survival rates were 75% at one year and 67% at 2 years. In conclusion, in non-cirrhotic patients with HCC resection is the treatment of choice. In cirrhotic patients limited resections should be preferred and liver transplantation is the best solution in selected cases; local ablative methods may be used for some unresectable tumors. The role of adjuvant chemotherapy has to be determined in future comparative studies.
authors.affiliation: Centrul de Chirurgie Generală şi Transplant Hepatic, Institutul Clinic Fundeni Sos. Fundeni, Nr. 258, Sector 2, Bucureşti. irinel.popescu@icfundeni.ro
authors.forename: I
authors.initials: I
authors.lastname: Popescu
authors.forename: M
authors.initials: M
authors.lastname: Ionescu
authors.forename: S
authors.initials: S
authors.lastname: Ciurea
authors.forename: V
authors.initials: V
authors.lastname: Braşoveanu
authors.forename: Patricia
authors.initials: P
authors.lastname: Sârbu-Boeţi
authors.forename: Doina
authors.initials: D
authors.lastname: Hrehoreţ
authors.forename: V
authors.initials: V
authors.lastname: Tomulescu
authors.forename: S
authors.initials: S
authors.lastname: Alexandrescu
authors.forename: B
authors.initials: B
authors.lastname: Dorobanţu
authors.forename: R
authors.initials: R
authors.lastname: Grigorie
authors.forename: C
authors.initials: C
authors.lastname: Jemna
authors.forename: Liana
authors.initials: L
authors.lastname: Gheorghe
authors.forename: Rodica
authors.initials: R
authors.lastname: Anghel
authors.forename: Adina
authors.initials: A
authors.lastname: Croitoru
authors.forename: V
authors.initials: V
authors.lastname: Herlea
authors.forename: Mirela
authors.initials: M
authors.lastname: Boroş
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012189:Retrospective Studies; D012383:Romania; D016019:Survival Analysis