title: Hypertrophic cardiomyopathy in systemic sclerosis. A report of two cases.
abstract: We describe two patients with diffuse systemic sclerosis (SSc) where the echocardiogram revealed asymmetric hypertrophy of the interventricular septum with signs of subaortic obstruction consistent with hypertrophic obstructive cardiomyopathy. Hypertrophic cardiomyopathy is associated with the human lymphocyte antigen (HLA DR3), and this may provide a possible link with SSc, as this HLA phenotype is common in the latter condition. However, further studies should examine whether a true association exists.
authors.affiliation: Department of Cardiology, Laiko Hospital, 6-8 Glykonos street, 106-75 Athens, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Moyssakis
authors.forename: D P
authors.initials: DP
authors.lastname: Papadopoulos
authors.forename: G
authors.initials: G
authors.lastname: Anastasiadis
authors.forename: P
authors.initials: P
authors.lastname: Vlachoyannopoulos
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D004452:Echocardiography; D005260:Female; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D014700:Verapamil