Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II.
Severe hyperbilirubinemia in a pregnant mother suffering from Crigler-Najjar syndrome type II is a threat to the unborn child and may result in brain injury. We report the case of a Gly71-->Arg/Tyr486-->Asp homozygous mother of East Asian descent, who was treated with phototherapy during embryogenesis and with phenobarbital during the rest of the pregnancy. This resulted in significantly reduced bilirubin levels in the mother, who gave birth to a healthy boy. A neonatal hyperbilirubinemia resolved spontaneously.
Holstein
Andreas
A
1st Department of Medicine, Klinikum Lippe-Detmold, Germany. Andreas.Holstein@t-online.de
Plaschke
Armin
A
Lohse
Peter
P
Egberts
Eick-Hartwig
EH
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D003414:Crigler-Najjar Syndrome / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D010789:Phototherapy; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome
D000927:Anticonvulsants; D010634:Phenobarbital