title: The influence of age in peripheral facial palsy on brainstem reflex excitability.
abstract: BACKGROUND
  Neuronal plasticity is expected to be different at different ages and adaptive changes developing after peripheral facial palsy (PFP) may provide a clue in this respect.
  
  
  OBJECTIVE
  To investigate the difference in the reorganization developing after facial nerve damage between patients who developed PFP at childhood-youth and middle-old age.
  
  
  METHODS
  Twenty-two patients were divided into two groups according to the age-at-onset of PFP; young (PFP 1), and elderly (PFP 2). Two age-matched control groups (C 1 and C 2) comprised of 32 healthy subjects were included in the study. The latency, R(2) area, and recovery of the R(2) area of the blink reflex were investigated.
  
  
  METHODS
  ANOVA and Bonferroni tests were used.
  
  
  RESULTS
  The R(2) areas were significantly greater on the intact side of the PFP 1 group as compared to that in the control group ( P =0.012). The recovery of R2 component was significantly enhanced on the symptomatic (P = 0.027), and intact (P = 0.041) sides in PFP 1 as compared to that in the C 2 group at the stimulus interval of 600 ms. Significant enhanced recovery was noted at 200 ms stimulus interval on the symptomatic side of the two PFP groups (PFP 1, P = 0.05 and PFP 2, P = 0.025) and on the intact side of the PFP 1 group (P =0.035) as compared to that in the control groups.
  
  
  CONCLUSIONS
  Young age-at-onset of PFP is associated with more prominent excitability changes developing at the neuronal and interneuronal level.
authors.affiliation: Department of Neurology, Istanbul University Cerrahpasa Medical School, Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Kiziltan
authors.forename: N
authors.initials: N
authors.lastname: Uzun
authors.forename: G
authors.initials: G
authors.lastname: Kiziltan
authors.forename: F K
authors.initials: FK
authors.lastname: Savrun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001933:Brain Stem / Q000503:physiopathology*; D002648:Child; D004576:Electromyography; D005158:Facial Paralysis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012018:Reflex / Q000502:physiology*; D012189:Retrospective Studies