title: [Lack of direct cytotoxic effect of intracellular nanotubes].
abstract: Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multi wall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of &apoptosis or necrosis at the doses used (up to 125 microg/mI).
authors.affiliation: Dipartimento di Biologia, Università di Roma Tor Vergata.
authors.forename: L
authors.initials: L
authors.lastname: Ghibelli
authors.forename: M
authors.initials: M
authors.lastname: De Nicola
authors.forename: G
authors.initials: G
authors.lastname: Somma
authors.forename: C
authors.initials: C
authors.lastname: Cerella
authors.forename: M
authors.initials: M
authors.lastname: D'Alessio
authors.forename: E
authors.initials: E
authors.lastname: Romeo
authors.forename: A
authors.initials: A
authors.lastname: Magrini
authors.forename: A
authors.initials: A
authors.lastname: Bergamaschi
mesh_terms: D017209:Apoptosis; D002478:Cells, Cultured; D003470:Culture Media; D006801:Humans; D037742:Nanotubes, Carbon / Q000633:toxicity*; D009336:Necrosis; D010586:Phagocytes; D013997:Time Factors; D018675:Toxicity Tests
chemical_list: D003470:Culture Media; D037742:Nanotubes, Carbon