title: Effects of multiple pulmonary aspirations of enteral solutions on lung tissue damage.
abstract: OBJECTIVE
  The aim of this study was to compare the pulmonary histopathologic effects of enteral solutions with various lipid content, after multiple aspirations in rats.
  
  
  METHODS
  Thirty Wistar albino rats were randomly assigned to one of three groups (n = 10). Saline solution (0.9%) (group C, control), Impact (lipid content, 28 g/l; group I), Pulmocare (lipid content, 93.3g/l; group P) were injected into the lung through the trachea, in a volume of 0.8 ml/kg. The aspiration procedure was performed three times in total, in every 2 days. After seven days from the first aspiration, rats were killed, and lungs were examined for histopathologic examination.
  
  
  RESULTS
  Alveolar histiocytes were statistically higher in left lungs of the group I than the left ones of the control group (P < 0.05). Lipid-laden alveolar macrophages were significantly higher in left lungs of groups I and, P than left lungs of the control group (P<0.05).
  
  
  CONCLUSIONS
  Lung tissue damage occurring after multiple pulmonary aspirations of Impact and Pulmocare, is histopathologically similar to each other, and is in the form of lipoid pneumonia. In cases of multiple pulmonary aspirations, volume of the aspirate and chronicity of the aspiration look like major impact factors rather than the amount of the lipid.
authors.affiliation: Department of Anesthesiology and Reanimation, Marmara University, Tophanelioğlu cad., Yurtacon sok, Istanbul, Turkey. tans6@hotmail.com
authors.forename: Tümay
authors.initials: T
authors.lastname: Umuroğlu
authors.forename: Arzu
authors.initials: A
authors.lastname: Takil
authors.forename: Pinar
authors.initials: P
authors.lastname: Irmak
authors.forename: Bedrettin
authors.initials: B
authors.lastname: Yildizeli
authors.forename: Rengin
authors.initials: R
authors.lastname: Ahiskali
authors.forename: Varlik
authors.initials: V
authors.lastname: Doğan
authors.forename: F Yilmaz
authors.initials: FY
authors.lastname: Göğüş
mesh_terms: D000818:Animals; D004750:Enteral Nutrition / Q000009:adverse effects*; D005223:Fats / Q000009:adverse effects / Q000032:analysis; D005260:Female; D005526:Food, Formulated / Q000009:adverse effects / Q000032:analysis; D006644:Histiocytes / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D011015:Pneumonia, Aspiration / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005223:Fats