The role of endothelin in heart failure.
Current treatments for heart failure extend the life of the patient but do not stop the progression of the disease process. These treatments may not be addressing the underlying cause of cellular injury. The role of endothelin in cardiac remodeling and inflammation may be important in the progression of failure, and endothelin antagonists may be beneficial in treatment in combination with drugs already in use.
Angerio
Allan D
AD
School of Nursing and Health Studies, Georgetown University, School of Nursing and Health Studies, Washington, DC 20057-1107, USA. angerioa@georgtown.edu
D000804:Angiotensin II / Q000378:metabolism; D017704:Baroreflex; D019332:Endothelin-1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D012084:Renin-Angiotensin System
D019332:Endothelin-1; D000804:Angiotensin II