title: Exploiting C3-symmetry in the dynamic coordination of a chiral trisoxazoline to copper(II): improved enantioselectivity, and catalyst stability in asymmetric lewis acid catalysis.
abstract: Chiral C3-symmetric trisoxazolines are highly efficient stereodirecting ligands in enantioselective Cu(II) Lewis acid catalysis which is based on the concept of a stereoelectronic hemilability of the divalent copper; in direct comparison with the analogous bisoxazoline systems they are more efficient in the enantioselective alpha-amination as well as the enantioselective Mannich reaction of prochiral beta-ketoesters.
authors.affiliation: Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
authors.forename: Carole
authors.initials: C
authors.lastname: Foltz
authors.forename: Björn
authors.initials: B
authors.lastname: Stecker
authors.forename: Guido
authors.initials: G
authors.lastname: Marconi
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bellemin-Laponnaz
authors.forename: Hubert
authors.initials: H
authors.lastname: Wadepohl
authors.forename: Lutz H
authors.initials: LH
authors.lastname: Gade