title: Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature.
abstract: BACKGROUND
  Oral mucosa squamous cell carcinoma (OSCC) has locoregional evolution, with frequent neck involvement (the most important parameter for prognosis). There are still many doubts concerning the best way to approach N0 neck disease in early-stage lesions (T1 and T2). Many parameters have been studied to identify N0 patients with a high likelihood of harboring occult node metastases or of having them develop.
  
  
  METHODS
  A review of the studies analyzing "tumor thickness"/"depth of invasion" in predicting regional metastases and survival was undertaken.
  
  
  RESULTS
  The literature suggests that "tumor thickness"/"depth of invasion" is a reliable parameter for predicting regional nodal involvement and survival in OSCC.
  
  
  CONCLUSIONS
  Authors are in substantial agreement regarding the reliability of tumor thickness. The lack of comparable study groups, measurement techniques, and cut-off values points to the need for further studies so as to reach a consensus and to develop therapy protocols that include tumor thickness.
authors.affiliation: Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Clinica Odontostomatologica, Sezione di Patologia e Medicina Orale, Corso Dogliotti 38, 10126 Torino, Italy. monica.pentenero@unito.it
authors.forename: Monica
authors.initials: M
authors.lastname: Pentenero
authors.forename: Sergio
authors.initials: S
authors.lastname: Gandolfo
authors.forename: Marco
authors.initials: M
authors.lastname: Carrozzo
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D011379:Prognosis; D016019:Survival Analysis