Radiosurgery in metastatic brain cancer.
Radiosurgery offers patients with brain metastases an effective and minimally invasive treatment modality. Radiosurgery provides local tumor control and prolongs survival in select patients with brain metastases. This review will discuss numerous aspects of radiosurgery, including the various delivery techniques and radiobiology. Treatment recommendations will be outlined in view of the available clinical data. Although surgery or radiosurgery with whole-brain radiotherapy remains an important option for patients with a solitary brain metastasis, radiosurgery with or without whole-brain radiotherapy should be considered in patients with a limited number of small tumors and a good prognosis.
McDermott
Michael W
MW
Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143, USA. McDermottM@neurosurg.ucsf.edu
Sneed
Penny K
PK
D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D006801:Humans; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods / Q000639:trends*; D017410:Practice Guidelines as Topic; D011853:Radiobiology; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods / Q000639:trends*; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies