title: Heart rate and systolic blood pressure variability: the impact of thinness and aging in human male subjects.
abstract: BACKGROUND
  Life spans are steadily increasing in developing countries where 'thinness' is widely prevalent. However, the interaction of aging and thinness has been poorly studied in terms of its physiological consequences.
  
  
  OBJECTIVE
  To determine the impact of aging and 'thinness' (body mass index (BMI) < 18.5 kg/m2) on resting heart rate and systolic blood pressure (SBP) variability indices in the frequency domain.
  
  
  METHODS
  Ninety seven healthy male subjects were divided into two age categories; young; 18-30 yrs and old superior 60 yrs. The subjects were further divided on the basis of BMI into young, thin (n=32), young, normal BMI (BMI 18.5-25, n = 27), old, thin (n = 15) and old, normal BMI (n = 23) groups.
  
  
  METHODS
  Cardiac autonomic nerve function was determined using heart rate variability indices in the frequency domain (low frequency, cardiac sympathetic 0.04- 0.15 Hz; high frequency, cardiac parasympathetic 0.15-0.4 Hz). Vasomotor sympathetic activity was determined from the low frequency component of SBP variability. Baroreflex sensitivity was determined from the spectral power of both RR variability and SBP variability between 0.07 to 0.14 Hz.
  
  
  RESULTS
  Thinness was associated with a reduction in the absolute total, low and high frequency heart rate power spectrum as compared to individuals of normal BMI, but this difference was only apparent in young adults (P < 0.05) and not in older subjects. The age related decline in heart rate variability (absolute units) was apparent for subjects of both low and normal BMI (P < 0.05). There were no differences in SBP variability either with age or BMI.
  
  
  CONCLUSIONS
  The data suggest that aging has a pronounced effect on heart rate variability, which may mask differences in heart rate variability related to thinness.
authors.affiliation: Division of Nutrition and Department of Physiology, St John's Medical College, Bangalore 560034, India. mariovaz@divnut.net
authors.forename: M
authors.initials: M
authors.lastname: Vaz
authors.forename: S
authors.initials: S
authors.lastname: Sucharita
authors.forename: A V
authors.initials: AV
authors.lastname: Bharathi
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D000886:Anthropometry; D001341:Autonomic Nervous System / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013851:Thinness / Q000503:physiopathology*