title: Evaluation of the Brighton Collaboration case definition of acute intussusception during active surveillance.
abstract: To evaluate the Brighton Collaboration case definition of acute intussusception, we reviewed all episodes reported to the Swiss Paediatric Surveillance Unit (SPSU) during 1 year (4/2003--3/2004). Of 96 confirmed episodes 86 (90%, 95% CI 83--96) were captured by the case definition. Of the remaining 10 episodes, 9 resolved spontaneously following presentation with clinical signs and symptoms, and ultrasound findings compatible with intussusception. Eighty-two episodes met level 1 of the definition, the highest level of diagnostic certainty. Compared to level 1, the sensitivity of level 2 (intermediate level) and level 3 (lowest level) was 65% (CI 55--74) and 30% (CI 20--40), respectively. In conclusion, the case definition was useful and applicable to assess the background rate of intussusception in the light of potential future rotavirus immunization.
authors.affiliation: University Children Hospital, Division of Pediatrics Infectious Diseases and Vaccines, Post Box, 4005 Basel, Switzerland.
authors.forename: Terhi
authors.initials: T
authors.lastname: Tapiainen
authors.forename: Gurli
authors.initials: G
authors.lastname: Bär
authors.forename: Jan
authors.initials: J
authors.lastname: Bonhoeffer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Heininger
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007443:Intussusception / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D013557:Switzerland; D014611:Vaccination / Q000009:adverse effects