title: Predictive power of maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis for the preterm delivery.
abstract: OBJECTIVE
  To investigate whether maternal serum and amniotic fluid CRP and PAPP-A concentrations at the time of genetic amniocentesis are markers of preterm delivery.
  
  
  METHODS
  One hundred and forty-one pregnant women were included in this prospective study. Amniotic fluid and maternal serum CRP and PAPP-A concentrations were determined by using commercially available kits. Receiver-operating characteristic (ROC) analysis was performed to determine the efficacy of maternal serum and amniotic fluid CRP and PAPP-A levels in predicting women with preterm delivery.
  
  
  RESULTS
  The prevalence of spontaneous preterm delivery before 37 weeks of gestation was 9.9%. ROC analysis revealed that amniotic fluid CRP level was the only parameter, which had a significant power in the prediction of preterm delivery. The optimum cut-off level was 0.65 mg/L. The sensitivity and specificity were 92.9% and 78.7%, respectively.
  
  
  CONCLUSIONS
  The amniotic fluid CRP level has a high sensitivity and specificity in the prediction of preterm delivery and this may be helpful in predicting preterm delivery during genetic amniocentesis.
authors.affiliation: Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Marmara University School of Medicine, Istanbul, Turkey. drkamerozer@hotmail.com
authors.forename: Kamer T
authors.initials: KT
authors.lastname: Ozer
authors.forename: Zehra N
authors.initials: ZN
authors.lastname: Kavak
authors.forename: Hüsnü
authors.initials: H
authors.lastname: Gökaslan
authors.forename: Koray
authors.initials: K
authors.lastname: Elter
authors.forename: Tanju
authors.initials: T
authors.lastname: Pekin
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005820:Genetic Testing; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D047928:Premature Birth / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D011266:Pregnancy-Associated Plasma Protein-A