Involvement of E2F transcription factor family in cancer.
The E2F family of transcription factors is a central modulator of important cellular events, including cell cycle progression, apoptosis and DNA damage response. The role of E2F family members in various human malignancies is yet unclear and may provide vital clues to the diagnosis, prognosis and therapy of cancer patients. In this review we provide a brief but concise overview of E2F function and its putative role in the most common human tumour types.
Tsantoulis
P K
PK
Department of Histology and Embryology, Molecular Carcinogenesis Group, School of Medicine, University of Athens, Antaiou 53 Str, Lamprini, Ano Patissia, GR-11146, Athens, Greece.
Gorgoulis
V G
VG
D000818:Animals; D002453:Cell Cycle; D045744:Cell Line, Tumor; D004249:DNA Damage / Q000235:genetics; D050684:E2F Transcription Factors / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*
D050684:E2F Transcription Factors