title: The impact of medical therapy on surgery for benign prostatic hyperplasia: a study comparing changes in a decade (1992-2002).
abstract: OBJECTIVE
  To compare the clinical profile (age, comorbidities, symptom severity, and incidence of acute urinary retention, AUR), the type and duration of medical treatment, and indications for surgery of patients undergoing surgery for benign prostatic hyperplasia (BPH) in 1992 and 2002 at one centre.
  
  
  METHODS
  In this single-centre, retrospective, cross-sectional observational study, the medical history of all patients who had surgery for BPH in the first semester of 1992 (85) and 2002 (70) was reviewed. The preoperative clinical profile was determined by assessing age, main comorbidities, prostatic volume, maximum urinary flow rate and symptom severity. The type and duration of pharmacology for BPH was evaluated from the medical history and telephone contact with the patients. Indications for surgery, the method of operation and the weight of removed tissue (open adenectomy) or the volume of the resected tissue (transurethral resection) were obtained from the patients' records and compared. Surgical complications in both groups were assessed, as was the average stay in hospital.
  
  
  RESULTS
  In our institution, surgery for BPH decreased by 17.6% in the decade, with patients having surgery when older, at a mean (sd) of 69.1 (8.57) vs 72.3 (7.59) years, i.e. 3.1 years older (P = 0.028), but with similar comorbidities. Reasons for surgery in 1992/2002, respectively, were AUR in 41/37%, and symptoms worsening in 48/51%. The few cases of haematuria and bladder stone were similarly distributed in both groups. Pharmacology for BPH was prescribed in 46% of patients in 1992, phytotherapy being the most common (89%), whereas in 2002, 82% (P < 0.01) were treated, most of them with alpha-adrenergic antagonists (79%). Open surgery was indicated in 18.8% of patients in 1992 (mean adenoma weight 73.8 g, sd 37.12) and in 28.6% in 2002 (79.8 g, sd 35.41; P = 0.625). The mean (sd) hospital stay was 8.9 (4.06) vs 5.0 (1.22) days in 1992 and 2002, respectively (P < 0.01) for transurethral resection, and 14.1 (5.74) vs 8.7 (4.83) for open adenectomy (P = 0.013). The complication rate was similar for both groups.
  
  
  CONCLUSIONS
  Compared with 1992, fewer patients with BPH have surgery, when older and after receiving medical treatment for longer. The indications for surgery are similar. Significantly more patients had open surgery, perhaps because the progressive increase in prostate volume was not affected by the medical therapy used predominantly during this decade.
authors.affiliation: Department of Urology, Clinical Epidemiology Unit, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain. rvela@fjd.es
authors.forename: Remigio
authors.initials: R
authors.lastname: Vela-Navarrete
authors.forename: Carmen
authors.initials: C
authors.lastname: Gonzalez-Enguita
authors.forename: Juan V
authors.initials: JV
authors.lastname: Garcia-Cardoso
authors.forename: Felix
authors.initials: F
authors.lastname: Manzarbeitia
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Sarasa-Corral
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Granizo
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000236:Adenoma / Q000188:drug therapy / Q000601:surgery*; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000367:Age Factors; D000368:Aged; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D018120:Finasteride / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D008517:Phytotherapy / Q000706:statistics & numerical data; D011467:Prostate / Q000601:surgery; D011468:Prostatectomy / Q000639:trends*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies
chemical_list: D058891:5-alpha Reductase Inhibitors; D000317:Adrenergic alpha-Antagonists; D004791:Enzyme Inhibitors; D018120:Finasteride