title: [A case of advanced gastric cancer effectively treated by combined chemotherapy of TS-1 and paclitaxel].
abstract: A patient was a 66-year-old male who had advanced gastric cancer with left gastric artery lymph node metastasis and invasion of pancreas and spleen. We thought a complete resection was difficult, so he was given neo-adjuvant chemotherapy by combined of TS-1 100 mg/day (2 weeks administration and 1 week rest) and Paclitaxel (PTX) 75 mg/body (day 1, 8). After 2 courses of this neo-adjuvant chemotherapy, tumor and lymph node swelling had decreased in size, and the tumor markers were reduced remarkably (CEA 9 2.5 --> 12.2 ng/ml, CA 19-9 2, 739 --> 19 3 U/ml). He underwent total gastrectomy and Roux-en Y reconstruction. No.4 d and No.7 lymph nodes were swollen and hard, but white with a neurotic-like appearance. On pathological study, no malignancy was seen in the lymph nodes, and a good partial response was achieved. In this chemotherapy, no side effects were seen, and he maintained good quality of life. TS-1/PTX therapy was thought to be an effective neoadjuvant chemotherapy for advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Kanagawa Prefectural Asigarakami Hospital.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamagawa
authors.forename: Katuya
authors.initials: K
authors.lastname: Yoneyama
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sugano
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Jin
authors.forename: Akio
authors.initials: A
authors.lastname: Kasahara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takanashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
mesh_terms: D000368:Aged; D000713:Anastomosis, Roux-en-Y; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009361:Neoplasm Invasiveness; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000473:pathology; D011725:Pyridines / Q000008:administration & dosage; D013160:Splenic Neoplasms / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel