title: In vivo volumetric analysis of coronary stent using optical coherence tomography with a novel balloon occlusion-flushing catheter: a comparison with intravascular ultrasound.
abstract: Optical coherence tomography (OCT) is limited as an intravascular imaging tool because of interference with blood. This study tested a new balloon occlusion-flushing catheter for OCT scanning of stented coronary arteries and compared stent measurements between OCT and intravascular ultrasound (IVUS). Motorized pullback with OCT and IVUS was examined in coronary stents deployed in swine. Quantitative measurements were obtained and compared between both groups. In addition, stent strut thickness was compared among OCT, IVUS and actual measurement. The occlusion catheter successfully provided motorized pullback OCT images in the stented coronary arteries without any complications. There were no differences in calculated lumen volume. However, stent volumes were significantly smaller with OCT than with IVUS (p < 0.05). OCT significantly underestimated the stent strut thickness compared with the actual measurement. Although OCT underestimates the stent strut thickness, motorized pullback OCT imaging with the occlusion catheter can provide appropriate in-stent images in the porcine coronary arteries.
authors.affiliation: Cardiology Laboratory for Integrative Physiology and Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. ykawase@partners.org
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawase
authors.forename: Kozo
authors.initials: K
authors.lastname: Hoshino
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Yoneyama
authors.forename: Jennifer
authors.initials: J
authors.lastname: McGregor
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hajjar
authors.forename: Ik-Kyung
authors.initials: IK
authors.lastname: Jang
authors.forename: Motoya
authors.initials: M
authors.lastname: Hayase
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation / Q000379:methods*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000601:surgery; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000601:surgery; D015607:Stents; D013552:Swine; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D018084:Ultrasonography, Interventional / Q000379:methods*