Difference in expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with persistent ovarian cysts.
Matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-9 expression with real-time quantitative polymerase chain reaction were analyzed in endometriotic and nonendometriotic ovarian cysts. Although MMP-1 was not detected, MMP-9 and MMP-2 were expressed in all of the cysts. In particular, in five of six nonendometriotic cysts (83.3%) MMP-2 expression was higher than in endometriotic cysts. These data may represent new molecular elements helpful in differential diagnosis of endometriotic lesions.
Raspollini
Maria Rosaria
MR
Department of Human Pathology and Oncology, Perinatology and Reproductive Medicine, University of Florence, School of Medicine, Florence, Italy. mariarosaria.raspollini@unifi.it
Castiglione
Francesca
F
Rossi Degl'Innocenti
Duccio
D
Garbini
Francesca
F
Coccia
Maria Elisabetta
ME
Taddei
Gian Luigi
GL
D002908:Chronic Disease; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D010048:Ovarian Cysts / Q000201:enzymology* / Q000235:genetics; D018709:Statistics, Nonparametric
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9