title: Expression of the immediate-early gene cFos in brain of the rats exposed to repeated 2 G influence.
abstract: Early gene c-Fos expression was studied by means of c-Fos protein immunostaining in brain locus coeruleus (LC) of the rats exposed to primary and repeated hypergravity. One-hour 2 G influence on rats induced in LC cells expression of c-Fos protein, pointing out early gene c-Fos expression and synaptic activation of LC neurons. After repeated 1-hour 2 G, postponed for 35 days after primary 30-day 2 G influence, expression of c-Fos protein in LC neurons was not found. This fact is considered as a sign of memorizing of primary hypergravity influence.
authors.affiliation: Endocrinological Scientific Centre of RAMS, Moscow, Russia. igakmajev@mtu-net.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Fidelina
authors.forename: I B
authors.initials: IB
authors.lastname: Krasnov
mesh_terms: D000818:Animals; D002498:Centrifugation; D005786:Gene Expression Regulation / Q000502:physiology*; D016762:Genes, fos / Q000502:physiology*; D018471:Hypergravity; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D014446:Tyrosine 3-Monooxygenase