title: The lymphatic vasculature: recent progress and paradigms.
abstract: The field of lymphatic research has been recently invigorated by the identification of genes and mechanisms that control various aspects of lymphatic development. We are beginning to understand how, starting from a subgroup of embryonic venous endothelial cells, the whole lymphatic system forms in a stepwise manner. The generation of genetically engineered mice with defects in different steps of the lymphangiogenic program has provided models that are increasing our understanding of the lymphatic system in health and disease. This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis.
authors.affiliation: Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. guillermo.oliver@stjude.org
authors.forename: Guillermo
authors.initials: G
authors.lastname: Oliver
authors.forename: Kari
authors.initials: K
authors.lastname: Alitalo
mesh_terms: D000818:Animals; D006801:Humans; D008207:Lymphatic Metastasis / Q000503:physiopathology; D008208:Lymphatic System / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D042601:Lymphatic Vessels / Q000033:anatomy & histology / Q000502:physiology*; D008209:Lymphedema / Q000503:physiopathology; D008954:Models, Biological; D042582:Vascular Endothelial Growth Factor C / Q000037:antagonists & inhibitors / Q000502:physiology; D042643:Vascular Endothelial Growth Factor D / Q000037:antagonists & inhibitors / Q000502:physiology
chemical_list: D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D