Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro.
Rosmarinic acid (RA), a water-soluble polyphenolic compound with anti-oxidative and anti-inflammatory activities, inhibited several important steps of angiogenesis including proliferation, migration, adhesion and tube formation of human umbilical vein endothelial cells (HUVEC) in a concentration-dependent manner. RA also reduced intracellular reactive oxygen species (ROS) level, H2O2-dependent VEGF expression and IL-8 release of endothelial cells. These findings suggested that the anti-angiogenic potential of RA might be related to its anti-oxidative activity, which further resulted in the inhibition of ROS-associated VEGF expression and IL-8 release.
Huang
Shuang-sheng
SS
School of Life Sciences, Institute of Biophysics, Lanzhou University, Lanzhou 730000, China.
Zheng
Rong-liang
RL
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D002934:Cinnamates / Q000494:pharmacology*; D053630:Depsides; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D011863:Radioimmunoassay; D000097123:Rosmarinic Acid
D020533:Angiogenesis Inhibitors; D002934:Cinnamates; D053630:Depsides; D000097123:Rosmarinic Acid