title: Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation.
abstract: [reaction: see text] We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.
authors.affiliation: Chemical Sciences, The Dow Chemical Company, Midland, Michigan 48674, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Briggs
authors.forename: Jerzy
authors.initials: J
authors.lastname: Klosin
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Whiteker
mesh_terms: D000586:Amination; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000737:chemistry; D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000737:chemistry; D000068180:Aripiprazole; D002384:Catalysis; D008745:Methylation; D015394:Molecular Structure; D017905:Phosphites / Q000737:chemistry* / Q000378:metabolism; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000889:Anti-Arrhythmia Agents; D014150:Antipsychotic Agents; D017905:Phosphites; D010879:Piperazines; D015363:Quinolones; D013449:Sulfonamides; C067192:ibutilide; D000068180:Aripiprazole; D012238:Rhodium