Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients.
The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. GCT patients with metastatic disease were more likely to have a variant type allele of the polymorphisms at codon 5 (age-adjusted odds ratio (aOR)=6.25; 95% CI=1.09-35.83; P=0.040) and codon 8 (aOR=4.63; 95% CI=1.35-15.93; P=0.015) than those with the localized disease. Therefore, BCL10 polymorphisms at codons 5 and 8 may play a role in the progression to advanced stage GCTs.
Inoue
Takamitsu
T
Department of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Ito
Takuo
T
Narita
Shintaro
S
Horikawa
Yohei
Y
Tsuchiya
Norihiko
N
Kakinuma
Hideaki
H
Mishina
Mutsuki
M
Nakamura
Eijiro
E
Kato
Tetsuro
T
Ogawa
Osamu
O
Habuchi
Tomonori
T
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D000074018:B-Cell CLL-Lymphoma 10 Protein; D002878:Chromosomes, Human, Pair 1; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human