Toxic effects of chromatographic fractions of Phyllanthus amarus on the serum biochemistry of rats.
Chromatographic fractions obtained from Phyllanthus amarus were tested for toxicity on the serum biochemistry of rats. The results revealed that some fractions of P. amarus had potentially deleterious effects on the blood and therefore caution should be exercised in the use of P. amarus as a medicinal plant.
Adedapo
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Department of Veterinary Physiology/Pharmacology, University of Ibadan, Nigeria. Adedapo3a@yahoo.co.uk
Abatan
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Idowu
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Olorunsogo
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D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001774:Blood Chemical Analysis; D004305:Dose-Response Relationship, Drug; D029803:Phyllanthus; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves; D051381:Rats; D012709:Serum Albumin / Q000187:drug effects*
D010936:Plant Extracts; D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase