title: Screening of some rare endemic Italian plants for inhibitory activity on 5-lipoxygenase.
abstract: The extracts of four rare plants found on the islands of Sicily, Vulcano and Marettimo, Southern Italy, were screened for their inhibitory effect on the production of leukotriene B4 by 5-lipoxygenase in intact cells. The methanol extracts of pods of Cytisus aeolicus and aerial parts of Thymus richardii were the most active extracts, inhibiting almost completely the leukotriene B4 production at 200 and 50 microg/ml, respectively.
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, Valencia, Spain.
authors.forename: José-María
authors.initials: JM
authors.lastname: Prieto
authors.forename: Ammar
authors.initials: A
authors.lastname: Bader
authors.forename: Francesca
authors.initials: F
authors.lastname: Martini
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Ríos
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
mesh_terms: D000818:Animals; D029865:Cytisus; D039761:Genista; D007975:Leukotriene B4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors; D009504:Neutrophils / Q000187:drug effects*; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology*; D029606:Plumbaginaceae; D051381:Rats; D017208:Rats, Wistar; D012802:Sicily; D046930:Thymus Plant
chemical_list: D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D007975:Leukotriene B4