[Contribution of the endogenous opioid system to regulation of heart resistance to the arrhythmogenic effect of short-term ischemia and reperfusio].
Preliminary selective blockade of micro, delta1, delta2, kappa1, and kappa2 opioid receptors proved to have no effect on the incidence of ventricular arrhythmias during a 10-min coronary occlusion and subsequent reperfusion in ketamine-anesthetized rats. We propose that the endogenous opioid system has no considerable role in regulation of heart resistance to the arrhythmogenic effect of short-term local ischemia and subsequent reperfusion.
Maslov
L N
LN
Liishmanov
A Iu
AIu
Budankova
E V
EV
Stakheev
D L
DL
Solenkova
N V
NV
Barzakh
E I
EI
Oeltgen
P R
PR
Gross
G J
GJ
Chang
W S
WS
D000818:Animals; D006331:Heart Diseases / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009292:Narcotic Antagonists / Q000008:administration & dosage; D018847:Opioid Peptides / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism*
D009292:Narcotic Antagonists; D018847:Opioid Peptides; D011957:Receptors, Opioid