title: A QSAR study on influenza neuraminidase inhibitors.
abstract: Influenza is a major respiratory infection associated with significant morbidity in the general population and mortality in elderly and high-risk patients. It is an RNA virus that contains two major surface glycoproteins, neuraminidase and hemagglutinin. These proteins are essential for infection. Neuraminidase has been found to be a potential target to control influenza virus. In this paper, we have developed 17 quantitative structure-activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward influenza neuraminidase.
authors.affiliation: Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
authors.forename: Rajeshwar P
authors.initials: RP
authors.lastname: Verma
authors.forename: Corwin
authors.initials: C
authors.lastname: Hansch
mesh_terms: D000577:Amides / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D019817:Benzoic Acid / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003517:Cyclopentanes / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009975:Orthomyxoviridae / Q000201:enzymology*; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000577:Amides; D000998:Antiviral Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D007546:Isoquinolines; D011759:Pyrrolidines; D019817:Benzoic Acid; D009439:Neuraminidase; C039109:isoquinoline; C032519:pyrrolidine