title: Difference in expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with persistent ovarian cysts.
abstract: Matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-9 expression with real-time quantitative polymerase chain reaction were analyzed in endometriotic and nonendometriotic ovarian cysts. Although MMP-1 was not detected, MMP-9 and MMP-2 were expressed in all of the cysts. In particular, in five of six nonendometriotic cysts (83.3%) MMP-2 expression was higher than in endometriotic cysts. These data may represent new molecular elements helpful in differential diagnosis of endometriotic lesions.
authors.affiliation: Department of Human Pathology and Oncology, Perinatology and Reproductive Medicine, University of Florence, School of Medicine, Florence, Italy. mariarosaria.raspollini@unifi.it
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Raspollini
authors.forename: Francesca
authors.initials: F
authors.lastname: Castiglione
authors.forename: Duccio
authors.initials: D
authors.lastname: Rossi Degl'Innocenti
authors.forename: Francesca
authors.initials: F
authors.lastname: Garbini
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Coccia
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Taddei
mesh_terms: D002908:Chronic Disease; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D010048:Ovarian Cysts / Q000201:enzymology* / Q000235:genetics; D018709:Statistics, Nonparametric
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9