Effect of two-week tail suspension on forelimb and hindlimb [correction of hindlimd] small arteries in rats.
This study was aimed at comparing the effect of 2-week tail suspension on the characteristics of median artery and saphenous artery isolated from forelimb and hindlimb, accordingly. The segments of arteries were mounted in two-channel myograph for recording their isometric wall tension. In post-suspension rats segments of saphenous artery showed augmented sensitivity to noradrenaline and serotonin. More than two-fold decreased of EC50 was observed both before and after endothelium removal. Along with that, the sensitivity of median artery segments to vasoconstrictors was similar in post-suspension and control rats. However, the diameter of relaxed median artery in post-suspension rats was increased. Relaxation to acetylcholine compared to controls was augmented in both vascular regions of post-suspension rats being more pronounced in saphenous artery preparations.
Tarasova
O
O
State Research Center of The Russian Federation-Institute for Biomedical Problems, Moscow, Russia. ovin@imbp.ru
Kalentchuk
V
V
Tsvirkoun
D
D
Vinogradova
O
O
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects; D005552:Forelimb / Q000098:blood supply*; D006614:Hindlimb / Q000098:blood supply*; D019417:Hindlimb Suspension; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects; D018474:Weightlessness Simulation
D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine