title: CD56-positive acute lymphoblastic leukemia.
abstract: We report a patient with lung cancer who developed CD56-positive acute lymphoblastic leukemia. He was referred to our hospital for thrombocytopenia. Atypical cells were found in the blood and the bone marrow. These cells were immunophenotypically positive for CD3epsilon, CD56, and terminal deoxynucleotidyl transferase, and negative for surface CD3, CD4, CD19, CD33, and myeloperoxidase. A small proportion of leukemic cells express CD13. There were no rearrangements of T-cell receptor (TCR)-beta, TCR-gamma, or immunoglobulin heavy chain. No Epstein-Barr virus was detected. Systemic examination did not detect any tumors other than pulmonary adenocarcinoma, and the patient was diagnosed as having acute natural killer (NK) cell leukemia. Chemotherapy was effective, and he achieved complete remission. The course of the disease was complicated by a lung abscess, and the patient died 3 months after the diagnosis. We considered that the diagnosis was blastic NK cell lymphoma/leukemia subtype. However, it actually was myeloid/NK cell precursor leukemia subtype that weakly expressed CD13.
authors.affiliation: Department of Hematology, Tonami General Hospital, Tonami, Toyama, Japan. eievui7@p1.tst.ne.jp
authors.forename: Sadaya
authors.initials: S
authors.lastname: Matano
authors.forename: Shintaro
authors.initials: S
authors.lastname: Terahata
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Tatshuho
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000368:Aged; D019002:CD56 Antigen / Q000378:metabolism*; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D019002:CD56 Antigen