title: [The impairement of bone formation and resorption in 25-year-old man with neglected celiac disease].
abstract: Bone turnover impairement and low bone density in 25-year-old man with active celiac disease was presented. The patient refused gluten-free diet compliance and clinically showed doughy abdomen, hyperpigmentation, finger clubbing and koilonychia. In serum, we obtained about 2-fold of formation markers (osteocalcin, bone alkaline phosphatase) and and 5-fold higher levels of resorption marker (collagen type I crosslinked C-telopeptide). The concentration of osteoprotegerin was slightly above normal range. We observed the trace amounts of 25-(OH)D in serum whereas the level of parathormone was 2-fold higher than in controls. Serum calcium and phosphorus were often below normal range. In dual X-ray absorptiometry (DXA) whole-body bone density was remarkably reduced. Our results suggest, that on gluten-containing diet the patient will develop lower bone mineral density and higher risk of fractures and skeletal deformities.
authors.affiliation: Zakładu Biochemii Klinicznej , Instytutu Matki i Dziecka, Warszawie. biochem@imid.med.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Gajewska
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Ambroszkiewicz
authors.forename: Kamil K
authors.initials: KK
authors.lastname: Hozyasz
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000378:metabolism*; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood; D053244:Osteoprotegerin; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D018160:Receptors, Cytoplasmic and Nuclear / Q000097:blood; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood
chemical_list: D006023:Glycoproteins; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D010710:Phosphates; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C506030:TNFRSF11B protein, human; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002118:Calcium