title: Multidrug-resistant tuberculosis detection, Latvia.
abstract: To improve multidrug-resistant tuberculosis (MDR-TB) detection, we successfully introduced the rpoB gene mutation line probe assay into the national laboratory in Latvia, a country with epidemic MDR-TB. The assay detected rifampin resistance with 91% sensitivity and 96% specificity within 1 to 5 days (vs. 12-47 days for BACTEC).
authors.affiliation: State Centre of Tuberculosis and Lung Diseases, Riga, Latvia.
authors.forename: Girts
authors.initials: G
authors.lastname: Skenders
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Fry
authors.forename: Inga
authors.initials: I
authors.lastname: Prokopovica
authors.forename: Silvija
authors.initials: S
authors.lastname: Greckoseja
authors.forename: Lonija
authors.initials: L
authors.lastname: Broka
authors.forename: Beverly
authors.initials: B
authors.lastname: Metchock
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Holtz
authors.forename: Charles D
authors.initials: CD
authors.lastname: Wells
authors.forename: Vaira
authors.initials: V
authors.lastname: Leimane
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology; D006801:Humans; D007844:Latvia / Q000453:epidemiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D013183:Sputum / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*
chemical_list: D000995:Antitubercular Agents