Plasma levels of endothelin-1, angiotensin II, nitric oxide and prostaglandin E in the venous and cavernosal blood of patients with erectile dysfunction.
OBJECTIVE
To determine the alterations in the plasma levels of endothelin-1, angiotensin II, nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in the venous and cavernosal blood of patients with organic and psychogenic erectile dysfunction (ED).


METHODS
The study included 32 patients complaining of ED; they were subdivided into two equal groups with either organic or psychogenic ED. Fifteen healthy potent age-matched male volunteers were enrolled as a control group. For each patient, venous and cavernosal blood samples were obtained, while venous blood was obtained from the controls.


RESULTS
There were significantly greater mean plasma levels of endothelin-1 and angiotensin II, and significantly lower mean plasma levels of NO and PGE(2), in the venous blood of patients with ED than in the controls. Patients with organic ED had significantly higher levels of endothelin-1 and significantly lower levels of NO in both venous and cavernosal blood than had those with psychogenic ED. There were significant positive correlations in both venous and cavernosal blood between endothelin-1 and angiotensin II, and between NO and PGE(2) in all patients with ED and the two subgroups. There were significant negative correlations between venous and cavernosal endothelin-1 and NO, endothelin-1 and PGE(2), angiotensin II and NO, and between angiotensin II and PGE(2).


CONCLUSIONS
The present results suggest that endothelin-1 could be a clinical marker of diffuse endothelial disease manifested by ED. As angiotensin-converting enzyme (ACE) activity controls angiotensin II there might be a rationale for the use of ACE inhibitors to prevent or treat ED. NO and PGE(2) may provide new strategies for the pharmacological treatment of ED.
El Melegy
Nagla Taha
NT
Medical Biochemistry, Faculty of Medicine, Assiut, Egypt. elmelegynagla@yahoo.com
Ali
Mohamed-Esam M
ME
Awad
Efat M A
EM
D000328:Adult; D000804:Angiotensin II / Q000097:blood*; D016022:Case-Control Studies; D015232:Dinoprostone / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D007172:Erectile Dysfunction / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010413:Penis / Q000098:blood supply; D020018:Sexual Dysfunctions, Psychological / Q000097:blood / Q000503:physiopathology; D014664:Vasodilation
D019332:Endothelin-1; D000804:Angiotensin II; D009569:Nitric Oxide; D015232:Dinoprostone