Can neck size in elastase-induced aneurysms be controlled? A prospective study.
OBJECTIVE
An earlier retrospective study indicated that the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the inflated balloon. We report the current prospective study to confirm our previous work.


METHODS
Ninety elastase-induced aneurysms were created in rabbits. Group 1 (n = 62) included cases in which the occlusion balloon resided low, completely within the brachiocephalic/subclavian arteries. Group 2 (n = 28) included cases in which the balloon resided high, within both the common carotid artery and brachiocephalic/subclavian arteries. Follow-up digital subtraction angiography was performed. The aneurysm sizes were measured and compared between groups. The Student t test and the Fisher exact test were used for statistical analysis.


RESULTS
The mean aneurysm neck diameter and width for group 1 was significantly larger than that of group 2 (3.4 +/- 1.2 and 2.3 +/- 0.9 mm, P < .001; 3.8 +/- 1.0 and 3.3 +/- 0.9 mm, P < .05, respectively). The proportion of wide-necked aneurysms in group 1 was significantly larger than that in group 2 (29% vs 4%; P < .005). Mean dome-to-neck ratios were 1.2 +/- 0.4 and 1.7 +/- 0.7 for groups 1 and 2 (P < .005). There was no significant difference in aneurysm height between groups 1 and 2 (8.0 +/- 1.7 and 7.5 +/- 2.2 mm; P > .05).


CONCLUSIONS
The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon.
Ding
Yong Hong
YH
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Dai
Daying
D
Lewis
Debra A
DA
Danielson
Mark A
MA
Kadirvel
Ramanathan
R
Mandrekar
Jayawant N
JN
Cloft
Harry J
HJ
Kallmes
David F
DF
D015901:Angiography, Digital Subtraction; D000818:Animals; D021721:Balloon Occlusion; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology*; D010196:Pancreatic Elastase; D011817:Rabbits
D010196:Pancreatic Elastase