title: Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids.
abstract: Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll-like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made without loss of TLR2 antagonistic activity.
authors.affiliation: Lead Optimization Department, Eisai Research Institute, 100 Research Drive, Wilmington, MA 01887, USA. mark_spyvee@eisai.com
authors.forename: Mark R
authors.initials: MR
authors.lastname: Spyvee
authors.forename: Huiming
authors.initials: H
authors.lastname: Zhang
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Hawkins
authors.forename: Jesse C
authors.initials: JC
authors.lastname: Chow
mesh_terms: D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D008958:Models, Molecular; D010743:Phospholipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D051195:Toll-Like Receptor 2 / Q000037:antagonists & inhibitors*
chemical_list: D007202:Indicators and Reagents; D010743:Phospholipids; D051195:Toll-Like Receptor 2