title: Orthogonal sulfation strategy for synthetic heparan sulfate ligands.
abstract: [reaction: see text] An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, USA.
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Fan
authors.forename: Jihane
authors.initials: J
authors.lastname: Achkar
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Hernández-Torres
authors.forename: Alexander
authors.initials: A
authors.lastname: Wei
mesh_terms: D002240:Carbohydrate Sequence; D006497:Heparan Sulfate / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D008024:Ligands; D008969:Molecular Sequence Data; D013431:Sulfates / Q000737:chemistry*
chemical_list: D006497:Heparan Sulfate; D008024:Ligands; D013431:Sulfates