Perinatal outcome of fetus with isolated congenital second degree atrioventricular block without maternal anti-SSA/Ro-SSB/La antibodies.
OBJECTIVE
We determined the perinatal outcomes of fetuses with isolated congenital second degree atrioventricular block detected in utero and born to mothers seronegative for anti-SSA/Ro-SSB/La antibodies.


METHODS
Isolated second degree atrioventricular block was defined as second degree atrioventricular block detected in utero without the accompanying structural cardiac anomaly, tachyarrhythmia, non-conducted premature atrial beats or long QT syndrome. We review our own cases and search from Medline using keywords such as atrioventricular block, arrhythmia, bradycardia and congenital to collect cases of congenital isolated second degree atrioventricular block.


RESULTS
Two cases were from our institution and five cases from a Medline search; in total seven cases of isolated second degree atrioventricular block without maternal anti-SSA/Ro-SSB/La antibodies were analyzed. Six of the seven fetal arrhythmias reverted to sinus rhythm by delivery and did not recur during the follow-up period. The prognosis of the fetus with isolated second degree atrioventricular block without maternal anti-SSA/Ro-SSB/La antibodies is better than that of the fetus with maternal anti-SSA/Ro-SSB/La antibodies or the fetus of congenital long QT syndrome with second degree atrioventricular block detected in utero.


CONCLUSIONS
The fetus with isolated congenital second degree atrioventricular block carries a good prognosis in the absence of maternal anti-SSA/Ro-SSB/La antibodies.
Chang
Yao-Lung
YL
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, No. 5 Fu-sin Street, Kweishang, Tao-Yuan Hsien, Taiwan.
Hsieh
Peter C C
PC
Chang
Shuenn-Dyh
SD
Chao
An-Shine
AS
Liang
Ching Chung
CC
Soong
Yung-Kuei
YK
D000974:Antibodies, Antinuclear / Q000097:blood*; D015415:Biomarkers; D005260:Female; D005313:Fetal Death; D006327:Heart Block / Q000151:congenital / Q000276:immunology / Q000401:mortality*; D006801:Humans; D008133:Long QT Syndrome / Q000151:congenital / Q000276:immunology / Q000401:mortality*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011379:Prognosis
D000974:Antibodies, Antinuclear; D015415:Biomarkers; C035356:SS-A antibodies; C035357:SS-B antibodies