[Comparison and improvement in the methods of establishing animals model of experimental chronic sinusitis in rabbits].
OBJECTIVE
To compare and improve the methods of establishing animal model of experimental chronic sinusitis in rabbits .


METHODS
Sixty-six New Zealand white rabbits were divided into seven groups: control group, sham-operation group I, sham-operation group II, bacteria inoculation group, ostia-blocked group, ostia-blocked and bacteria inoculation group, incomplete ostium blocked and set-cotton group. The animals were examined by the methods of histology and bacteriology after 42 days.


RESULTS
The positive rate of chronic inflammation in ostium blocked group was 80%, inoculated staphylococcus group was 100%, incomplete ostium blocked and set-cotton group was 100%, and the other groups were 0%. All infected sinuses displayed signs of moderate or severe chronic inflammation. The cultivated bacteria were mainly opportunistic pathogens. The probability of having abscess in maxillary sinus was high in ostia-blocked and bacteria inoculation group.


CONCLUSIONS
The method of incomplete ostium blockage and set cotton can establish stable chronic sinusitis model, it is a simple and perfect method.
Lin
Bin
B
Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Medicine College, Shantou University, Shantou 515041, China. longzaidahai@sohu.com
Wang
Hui-Ge
HG
Lin
Xin-Qiang
XQ
Liu
Xiao-Fen
XF
Huang
Yuan-Chun
YC
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D011817:Rabbits; D012852:Sinusitis / Q000382:microbiology