Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation.
Leiomyosarcomas (LM) of the soft tissue comprise approximately 5-10% of all soft tissue sarcomas. Besides the classic LM, several distinctly uncommon features of the cellular and growth patterns of LM have been described. The term "dedifferentiated LM" has rarely been used in the literature to describe soft tissue LM containing areas of undifferentiated, pleomorphic appearance or detectable heterologous differentiation. We report on a case of high-grade LM with almost entire transition to an osteosarcoma, which was classified as recurrent high-grade LM with heterologous osteosarcomatous differentiation. The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies.
Grabellus
Florian
F
Institute of Pathology, University Hospital of Essen, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. florian.grabellus@medizin.uni-essen.de
Sheu
Sien-Yi
SY
Schmidt
Boris
B
Flasshove
Michael
M
Kuhnen
Cornelius
C
Ruchholtz
Steffen
S
Taeger
Georg
G
Schmid
Kurt Werner
KW
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000378:metabolism / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology*