title: Pharmaceutical cost comparison analysis of antimicrobial use for surgical prophylaxis on gastrectomy patients in a tertiary care hospital.
abstract: The present study investigated the clinical effects and therapeutic cost of cefazolin (CEZ) and ampicillin/sulbactam (SBT/ABPC) compared to analyze cost-effectiveness for surgical prophylaxis in gastric cancer patients. 157 inpatients who underwent surgery for gastric cancer were investigated. There was no difference between the two groups with regard to sex, age, incidence of complication, stage of cancer, operative time and blood loss, length of hospitalization, the appearance of systematic inflammatory responses syndrome and the prophylactic effect of infection. Meanwhile, decision analysis indicated that the anticipated therapeutic cost per patient in CEZ group was less than that of SBT/ABPC group (USD 142.72 and USD 187.17, respectively). In this case, CEZ use was more cost-effective, insofar as only drug cost was considered.
authors.affiliation: Department of Pharmaceutical Service, Nippon Medical School Hospital, Tokyo, Japan. yuyaise@nms.ac.jp
authors.forename: Yuya
authors.initials: Y
authors.lastname: Ise
authors.forename: Ken
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Onda
authors.forename: Miwako
authors.initials: M
authors.lastname: Kamei
authors.forename: Shirou
authors.initials: S
authors.lastname: Katayama
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishizawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirano
authors.forename: Teruo
authors.initials: T
authors.lastname: Kiyama
mesh_terms: D000667:Ampicillin / Q000191:economics* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000191:economics*; D001424:Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control; D002437:Cefazolin / Q000191:economics* / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D004359:Drug Therapy, Combination; D005743:Gastrectomy; D006801:Humans; D007564:Japan; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D013274:Stomach Neoplasms / Q000601:surgery*; D013407:Sulbactam / Q000191:economics* / Q000627:therapeutic use
chemical_list: D000667:Ampicillin; D002437:Cefazolin; D013407:Sulbactam