Relationship between immune status and activity of the lymphocyte energy supply system in adolescents suffering from frequent diseases.
Children and adolescents aged 4-16 years with the diagnosis of acute respiratory viral infection with long-lasting fever, manifestations of intoxication syndrome, and catarrhal symptoms were examined. In children and adolescents suffering from frequent diseases and presented with acute respiratory viral infection we found disorders in the immune status (depression of the cellular component, helper/suppressor imbalance, suppressed production of IgA and hyperproduction of IgM, decreased concentration of secretory IgA in the saliva) in comparison with children rarely falling ill. The redox potential and lymphocyte cytochrome C content were decreased in adolescents often falling ill, while the content of cytochrome oxidase did not change. A negative multiple correlation (R=6.8, p<0.005) was detected between the decrease in cytochrome C content and NADP/NADPH redox potential and increase in the immunoregulatory index. ATP content in lymphocyte from adolescents frequently falling ill remained 21% decreased during the first 2 weeks after acute respiratory viral infection, while the ATP/ADP ratio was shifted towards dinucleotide, which also indicated disorders in ATP synthesis in lymphocytes.
Sukoyan
G V
GV
N. V. Karsanov National Center of Medical Biophysics and Introduction of Biomedical Technologies, Tbilisi.
Mamuchishvili
I G
IG
Pagava
K I
KI
D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000032:analysis; D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000378:metabolism; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003574:Cytochrome c Group / Q000032:analysis; D004734:Energy Metabolism; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007958:Leukocyte Count; D008156:Luciferases / Q000378:metabolism; D009113:Muramidase / Q000032:analysis; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology / Q000821:virology*; D012463:Saliva / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000911:Antibodies, Monoclonal; D003574:Cytochrome c Group; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009243:NAD; D009249:NADP; D000255:Adenosine Triphosphate; D008156:Luciferases; D009113:Muramidase