Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes.
New Baylis-Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity.
Narender
P
P
Organic Chemistry Division-II, Indian Institute of Chemical Technology,Uppal Road, Tarnaka, Hyderabad 500007, India.
Srinivas
U
U
Gangadasu
B
B
Biswas
Sukla
S
Rao
V Jayathirtha
VJ
D000447:Aldehydes / Q000138:chemical synthesis*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D002712:Chlorides; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000447:Aldehydes; D000962:Antimalarials; D002712:Chlorides; C014785:3-pyridinaldehyde