Enantioface-selective palladium-catalyzed silaboration of allenes via double asymmetric induction.
Enantioenriched beta-borylallylsilanes were synthesized by palladium-catalyzed enantioface-selective addition of the silicon-boron bond to terminal allenes using a palladium catalyst possessing a chiral monodentate phosphine ligand. Use of a silylborane bearing a chiral auxiliary on the boron atom was beneficial to gain enantioface selectivities as high as 96% de.
Suginome
Michinori
M
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, and PRESTO, Japan Science and Technology Corporation (JST), Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. suginome@sbchem.kyoto-u.ac.jp
Ohmura
Toshimichi
T
Miyake
Yoshihiro
Y
Mitani
Shin'ichirou
S
Ito
Yoshihiko
Y
Murakami
Masahiro
M