An efficient and practical synthesis of bis(indolyl)methanes catalyzed by aminosulfonic acid under ultrasound.
Synthesis of bis(indolyl)methanes via electrophilic substitution reactions of indoles with aromatic aldehydes and ketones catalyzed by aminosulfonic acid was carried out in 23-96% yield at 30-38 degrees C in EtOH aqueous solution under ultrasound irradiation.
Li
Ji-Tai
JT
College of Chemistry and Environmental Science, Hebei University, Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, PR China. orgsyn@mail.hbu.edu.cn
Dai
Hong-Guang
HG
Xu
Wen-Zhi
WZ
Li
Tong-Shuang
TS
D002384:Catalysis; D007211:Indoles / Q000737:chemistry* / Q000528:radiation effects; D008697:Methane / Q000737:chemistry* / Q000528:radiation effects; D013010:Sonication; D013451:Sulfonic Acids / Q000737:chemistry* / Q000528:radiation effects
D007211:Indoles; D013451:Sulfonic Acids; C005741:sulfamic acid; D008697:Methane