title: Sequential cardiac troponin T following delivery and its relationship with myocardial performance in neonates with respiratory distress syndrome.
abstract: We measured serial cardiac troponin T in babies with respiratory distress syndrome and in "healthy" controls (no cardiorespiratory support required). We investigated relationships between cardiac troponin T and myocardial performance in respiratory distress syndrome. This was a prospective observational study at a large tertiary maternity unit that recruited 104 "healthy" babies from whom individual samples were collected. A further 24 infants with respiratory distress syndrome and 14 "healthy" preterm infants had serial sampling over the first three days. We measured fractional shortening in 14 of the infants with respiratory distress syndrome. Cardiac troponin T rose from a median (interquartile range) of 10 (10-11) pg/mL on day one to 34 (22-46) pg/mL by day three, p=0.005, in "healthy" babies. In respiratory distress syndrome levels were higher, 91 (46-135) pg/mL at 6 (5-7) hours of age, p<0.001, and remained so for all three days. In babies with respiratory distress syndrome on day one cardiac troponin T correlated negatively with fractional shortening, Rho=-0.831, p<0.001, but this correlation did not persist. In "healthy" babies there is a minimal rise of cardiac troponin T by day 3. In respiratory distress syndrome there is an early and sustained elevation of cardiac troponin T, with a negative relationship with fraction shortening, suggesting significant myocardial damage of antenatal/intrapartum origin, giving rise to measurable dysfunction.
authors.affiliation: Jessop Wing, Royal Hallamshire Hospital, Tree Root Walk, Sheffield, S10 2SF, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Clark
authors.forename: Paul
authors.initials: P
authors.lastname: Newland
authors.forename: C William
authors.initials: CW
authors.lastname: Yoxall
authors.forename: Nimish V
authors.initials: NV
authors.lastname: Subhedar
mesh_terms: D002316:Cardiotonic Agents / Q000627:therapeutic use; D004452:Echocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D013318:Stroke Volume / Q000502:physiology; D013997:Time Factors; D020107:Troponin T / Q000097:blood*; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D002316:Cardiotonic Agents; D020107:Troponin T