title: Familial cluster headache. Is atypical cluster headache in family members part of the clinical spectrum?
abstract: Familial cluster headache (CH) was analysed in 21 Swedish families. Diagnosis was made according to The International Classification of Headache Disorders 2004. We identified 55 affected, of whom 42 had episodic or chronic CH, one had probable CH and 12 had atypical symptoms. The atypical cases did not fulfil the diagnostic criteria for CH, but had clinical symptoms with more resemblance to CH than to migraine or other trigeminal autonomic cephalgia syndromes. The overall male : female ratio was 1.8:1. The overall mean age at onset was significantly lower in the second/third generation than in the first generation (mean age at onset 22 vs. 31 years, SD +/- 7 vs. 13 years; P < 0.01). This may be anticipation or selection bias, since individuals with late age at onset from the second/third generation may not yet have symptoms. The prevalence of migraine was 24% (13/55), i.e. similar to the prevalence in the general population. The high incidence of atypical CH cases in the Swedish families with other members affected with CH may suggest that the spectrum of CH is broader than previously thought. We suggest that atypical CH in CH families may represent an expanded spectrum of the disease with a common aetiology, i.e. a common genetic background.
authors.affiliation: Department of Neurology, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden. christina.sjostrand@neurotec.ki.se
authors.forename: C
authors.initials: C
authors.lastname: Sjöstrand
authors.forename: M B
authors.initials: MB
authors.lastname: Russell
authors.forename: K
authors.initials: K
authors.lastname: Ekbom
authors.forename: J
authors.initials: J
authors.lastname: Hillert
authors.forename: E
authors.initials: E
authors.lastname: Waldenlind
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D003027:Cluster Headache / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology; D010375:Pedigree; D015995:Prevalence