Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-alpha, PPAR-gamma, and PPAR-delta, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. In this review, we summarize the critical role of PPARs in regulating inflammation, lipoprotein metabolism, and glucose homeostasis and their potential implications for the treatment of obesity, diabetes, and atherosclerosis.
Blaschke
Florian
F
Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. fblaschke@mednet.ucla.edu
Takata
Yasunori
Y
Caglayan
Evren
E
Law
Ronald E
RE
Hsueh
Willa A
WA
D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism*
D047492:Peroxisome Proliferator-Activated Receptors