title: Effect of 10 yr of the iodine supplementation on the hearing threshold of iodine deficient schoolchildren.
abstract: OBJECTIVE
  Auditory disturbances may be present in iodine deficient children. The aim of this study was to determine the effect of long-term iodine supplementation on auditory thresholds in iodine deficient children.
  
  
  METHODS
  70, 70 and 72 schoolchildren of an area of severe iodine deficiency were studied before intervention (1989), 3 yr after injection of 480 mg iodized oil (1992) and 7 yr after consumption of iodized salt (1999), respectively. Goiter was graded and serum T4, T3, TSH and thyroglobulin concentrations and urinary iodine levels were measured. Audiometry was performed with a pure tone audiometer.
  
  
  RESULTS
  There was significant decrease in the prevalence and severity of goiter and serum TSH and thyroglobulin concentrations, and significant rise in serum T4 in 1992 and 1999, as compared to 1989. Before iodine supplementation, hearing was abnormal in 44% of schoolchildren, mean hearing threshold was 15.8 +/- 5.9 and in all children was >10 dB. Mean hearing threshold decreased to 10.2 +/- 4.6 and 10.0 +/- 5.9, 3 and 10 yr after intervention (p < 0.001). Forty seven and 62% of children had thresholds < 10 dB in 1992 and 1999, respectively. Hearing thresholds > 15 dB were detected in 46, 11 and 10% of schoolchildren in 1989, 1992 and 1999, respectively (p < 0.001).
  
  
  CONCLUSIONS
  Continuous iodine supplementation permanantly improves the auditory thresholds of iodine deficient children.
authors.affiliation: Endocrine Research Center and Department of Medicine, Taleghani Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran I.R., Iran. iced@erc-iran.com
authors.forename: F
authors.initials: F
authors.lastname: Azizi
authors.forename: P
authors.initials: P
authors.lastname: Mirmiran
authors.forename: M
authors.initials: M
authors.lastname: Hedayati
authors.forename: N
authors.initials: N
authors.lastname: Salarkia
authors.forename: S
authors.initials: S
authors.lastname: Noohi
authors.forename: D
authors.initials: D
authors.lastname: Rostamian
mesh_terms: D000293:Adolescent; D001309:Auditory Threshold; D002648:Child; D003430:Cross-Sectional Studies; D019587:Dietary Supplements; D005260:Female; D006043:Goiter, Endemic / Q000473:pathology; D006309:Hearing / Q000502:physiology; D006801:Humans; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency*; D007459:Iodized Oil / Q000008:administration & dosage; D007492:Iran; D008137:Longitudinal Studies; D008297:Male; D011897:Random Allocation; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage
chemical_list: D017673:Sodium Chloride, Dietary; C034024:iodized salt; D007459:Iodized Oil; D007455:Iodine