title: TAP 2 gene Msp-I polymorphism might be associated with calcium oxalate stone disease.
abstract: BACKGROUND
  Inflammation might be one of the causes of stone disease. The function of the transporter associated with antigen-processing protein (TAP) is related to immune response and inflammation. Our aim was to investigate the relationship between stone disease and 5 polymorphic sites of the TAP gene (TAP1-1, 1-2, 2-1, 2-2, 2-3).
  
  
  METHODS
  We compared the frequencies of 5 polymorphisms in the TAP gene between 208 patients with recurrent calcium oxalate stone and 210 healthy controls. The polymorphism was detected by polymerase chain reaction-based restriction analysis.
  
  
  RESULTS
  Significant differences in the frequency of the polymorphism at the TAP2-2 site were detected between normal individuals and calcium stone disease patients (p<0.0001). The distribution of the genotype AA homozygote was higher in stone patients (33.3%) than in the control group (16.3%). The odds ratio for the A allele compared with the G allele was 2.097 (95% CI 1.571-2.802).
  
  
  CONCLUSIONS
  We conclude that the TAP2-2 MspI polymorphism might be associated with calcium stone disease.
authors.affiliation: Division of Urology, Department of Surgery, Changhua Christian Hospital, and Postgraduate Institute of Medical Research, China Medical University, Taichung, Taiwan.
authors.forename: Sheng-Hsien
authors.initials: SH
authors.lastname: Huang
authors.forename: Rong-Hsing
authors.initials: RH
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Wan
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Wen-Chi
authors.initials: WC
authors.lastname: Chen
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000368:Aged; D000483:Alleles; D002129:Calcium Oxalate / Q000032:analysis*; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D014545:Urinary Calculi / Q000097:blood / Q000737:chemistry / Q000235:genetics*
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D005819:Genetic Markers; C071692:TAP2 protein, human; D002129:Calcium Oxalate; D004247:DNA