title: Gamma/delta T-cell receptor type granular lymphocyte proliferative disorder associated with rheumatoid arthritis.
abstract: We present here a case report of a 69-year-old female patient with T granular lymphocyte proliferative disorder (T-GLPD) expressing the gamma/delta T-cell receptor. The patient had been treated for rheumatoid arthritis for 25 years, and presented with mild anaemia. Cell-surface marker analysis was carried out using flow cytometry and natural killer function was determined using a chromium release assay. The case report is followed by a summary of the 21 other gamma/delta T-GLPD cases reported in the literature and a comparison of their clinical characteristics with those of T-GLPD cases expressing the alpha/beta T-cell receptor. The clinical symptoms and the frequency of association with rheumatoid arthritis are similar in gamma/delta and alpha/beta T-GLPD, but a prevalence of the CD8- cell-surface marker and enhanced natural killer function appear to be characteristics of gamma/delta T-GLPD.
authors.affiliation: Department of Medicine, Kakogawa Prefectural Hospital, Kakogawa, Hyogo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Zenibayashi
authors.forename: K
authors.initials: K
authors.lastname: Saigo
authors.forename: N
authors.initials: N
authors.lastname: Chayahara
authors.forename: Y
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Inujima
authors.forename: Y
authors.initials: Y
authors.lastname: Imamura
authors.forename: M
authors.initials: M
authors.lastname: Takada
authors.forename: S
authors.initials: S
authors.lastname: Kawano
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: S
authors.initials: S
authors.lastname: Kumagai
mesh_terms: D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D016692:Receptors, Antigen, T-Cell, gamma-delta