[Adhesion molecules in type 2 diabetes].
Abnormal levels some of serum soluble adhesion molecules (ICAM-1, VICAM-1, E-selectin, P-selectin, L-selectin) have been detected in type 2 diabetic patients. There is some evidence that levels of soluble adhesion molecules depend on glycemic control, disturbances of lipid metabolism, obesity and insulin resistance. There is a few of clinical data till now, which have been suggested the significance role of adhesion molecules in pathogenesis of microangiopathy and macroangiopathy in type 2 diabetics. It is possible that in some cases measurement of serum adhesion molecules may be useful for predicting, early diagnosing prophylactic and monitoring of treatment of diabetic type 2 complications. We can modify serum levels of soluble adhesion molecules by nonpharmacologic and pharmacologic treatment.
Sokup
Alina
A
Katedra i Klinika Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych AMB, SPZOZ Wojewódzki Szpital im. dr J. Biziela 85-168 Bydgoszcz, ul. Ujejskiego 75. alinasokup@o2.pl
D015815:Cell Adhesion Molecules / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D012307:Risk Factors; D019087:Selectins / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D015815:Cell Adhesion Molecules; D019087:Selectins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1