title: Concise approach to novel isothiazolidinone phosphotyrosine mimetics: microwave-assisted addition of bisulfite to activated olefins.
abstract: [reaction: see text] A novel and efficient synthesis of isothiazolidinone protein tyrosine phosphatase mimetics is presented. A practical, regiospecific microwave-assisted addition of bisulfite to activated olefins, including unprecedented reactions with styrene derivatives, is highlighted.
authors.affiliation: Discovery Chemistry, Experimental Station, Incyte Corporation, Wilmington, Delaware 19880, USA. mcrawley@incyte.com
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Crawley
authors.forename: Erin
authors.initials: E
authors.lastname: McLaughlin
authors.forename: Wenyu
authors.initials: W
authors.lastname: Zhu
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Combs
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D008872:Microwaves; D018716:Molecular Mimicry; D015394:Molecular Structure; D019000:Phosphotyrosine / Q000737:chemistry*; D013447:Sulfites / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000475:Alkenes; D013447:Sulfites; D013844:Thiazoles; C512915:isothiazolidinone; D019000:Phosphotyrosine