title: Single-fraction radiosurgery for the treatment of spinal breast metastases.
abstract: BACKGROUND
  The spine is the most common site of bony metastases in patients with osseous breast carcinoma metastases. Spine metastases are the source of significant pain and occasionally neurologic deficit in this patient population. Conventional external beam radiotherapy lacks the precision to allow delivery of large single-fraction doses of radiation and simultaneously limit the dose to radiosensitive structures such as the spinal cord. This study evaluated the clinical efficacy of the treatment of spinal breast carcinoma metastases with a single-fraction radiosurgical technique.
  
  
  METHODS
  In this prospective cohort evaluation, 68 breast carcinoma metastases to the spine in 50 patients were treated with a single-fraction radiosurgery technique with a follow-up period of 6-48 months, median 16 months. The most common indication for radiosurgery treatment was pain in 57 lesions, as a primary treatment modality in 8 patients, and for radiographic tumor progression, as a postsurgical boost, and for a progressive neurologic deficit in 1 patient each.
  
  
  RESULTS
  Tumor volume ranged from 0.8-197 cm3 (mean, 27.7 cm3). Maximum tumor dose was maintained at 15-22.5 Gy (mean, 19 Gy). No radiation-induced toxicity occurred during the follow-up period (6-48 mo). Long-term axial and radicular pain improvement occurred in 55 of 57 (96%) patients who were treated primarily for pain. Long-term radiographic tumor control was seen in all patients who underwent radiosurgery as their primary treatment modality, for radiographic tumor progression, or as a postsurgical treatment.
  
  
  CONCLUSIONS
  Spinal radiosurgery was found to be feasible, safe, and clinically effective for the treatment of spinal metastases from breast carcinoma. The results indicate the potential of radiosurgery in the treatment of patients with spinal breast metastases, especially those with solitary sites of spine involvement, to improve long-term palliation.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. gersztenpc@upmc.edu
authors.forename: Peter C
authors.initials: PC
authors.lastname: Gerszten
authors.forename: Steven A
authors.initials: SA
authors.lastname: Burton
authors.forename: William C
authors.initials: WC
authors.lastname: Welch
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brufsky
authors.forename: Barry C
authors.initials: BC
authors.lastname: Lembersky
authors.forename: Cihat
authors.initials: C
authors.lastname: Ozhasoglu
authors.forename: William J
authors.initials: WJ
authors.lastname: Vogel
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary* / Q000601:surgery*; D001943:Breast Neoplasms / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000556:secondary* / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D016634:Radiosurgery; D013131:Spine / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome