Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae.
In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 microg of glucan by i.p. route, were assayed. In vivo beta-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work.
Pelizon
A C
AC
Department of Microbiology and Immunology, Institute of Biosciences, State University of Sao Paulo, Sao Paulo, Brasil.
Kaneno
R
R
Soares
A M V C
AM
Meira
D A
DA
Sartori
A
A
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010228:Paracoccidioides / Q000166:cytology / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D047071:beta-Glucans / Q000008:administration & dosage* / Q000276:immunology*
D000935:Antifungal Agents; D016207:Cytokines; D007155:Immunologic Factors; D047071:beta-Glucans