title: Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.
abstract: A series of dithiines were synthesized by cyclization of 4-(alkylamino)-4-oxobutanoic acids under the action of SOCl2. Their in vitro antibacterial and antifungal activities have been evaluated against reference strains and versus reference compounds. The so-called 'isoimides' 2a, 2b were totally inactive whereas some imides had low MICs for few bacteria and for few fungal microorganisms.
authors.affiliation: Chimie et biologie des substances naturelles, FRE 2125 CNRS, 6, rue de l'Université, 29000 Quimper, France. zentz@univ-brest.fr
authors.forename: F
authors.initials: F
authors.lastname: Zentz
authors.forename: R
authors.initials: R
authors.lastname: Labia
authors.forename: D
authors.initials: D
authors.lastname: Sirot
authors.forename: O
authors.initials: O
authors.lastname: Faure
authors.forename: R
authors.initials: R
authors.lastname: Grillot
authors.forename: A
authors.initials: A
authors.lastname: Valla
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003500:Cyclization; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007094:Imides / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007094:Imides; D013388:Succinimides; D013457:Sulfur Compounds