title: The frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children.
abstract: Ex vivo interferon (IFN)- gamma -producing CD8 T cells specific for human immunodeficiency virus (HIV) Env, Gag, and Pol antigens were measured in the peripheral blood of 55 children not receiving highly active antiretroviral therapy (HAART) and 70 children receiving HAART. In children not receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was positively correlated with age and was not associated with plasma viral load or CD4 T cell levels. In children receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was directly correlated with plasma viral load, and its association with age remained significant. In conclusion, the frequency of HIV-specific IFN- gamma -producing CD8 T cells in children is primarily determined by both age and plasma viral load.
authors.affiliation: Unite Postulante d'Immunopathologie Virale, Institut Pasteur, Paris, France. florence@pasteur.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Buseyne
authors.forename: Daniel
authors.initials: D
authors.lastname: Scott-Algara
authors.forename: N
authors.initials: N
authors.lastname: Bellal
authors.forename: M
authors.initials: M
authors.lastname: Burgard
authors.forename: C
authors.initials: C
authors.lastname: Rouzioux
authors.forename: Stephane
authors.initials: S
authors.lastname: Blanche
authors.forename: Yves
authors.initials: Y
authors.lastname: Riviere
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000276:immunology*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D012367:RNA, Viral / Q000097:blood; D012191:Retroviridae Proteins / Q000276:immunology; D019562:Viral Load
chemical_list: D012367:RNA, Viral; D012191:Retroviridae Proteins; D007371:Interferon-gamma