title: [Historical background of researches in headache].
abstract: In seventeenth century, Thomas Willis pointed out the source of headache is distention of the vessels nearly identical with Wolf's twentieth century vascular hypothesis of migraine. The concept of the pathophysiology in migraine swung to neural cause by Edward Liveing (1873). The research evidence for special role of serotonin was revealed by modern approach and the mechanism of migraine was presented in trigeminovascular system. The development of the basic science leads to new treatments in headache clinic.
authors.affiliation: Department of Medicine, Tokyo Women's Medical University, School of Medicine, Daini Hospital.
authors.forename: Koichi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D006261:Headache / Q000266:history*; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D008881:Migraine Disorders / Q000266:history