Information networks in the mammary gland.
Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation, differentiation, survival and death of cells. Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections.
Hennighausen
Lothar
L
Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. lotharh@amb.niddk.nih.gov
Robinson
Gertraud W
GW
D000818:Animals; D030801:Animals, Genetically Modified; D019070:Cell Lineage; D016207:Cytokines / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology / Q000637:transplantation; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000254:growth & development* / Q000502:physiology*; D042361:Mammary Glands, Human / Q000033:anatomy & histology / Q000254:growth & development* / Q000502:physiology*; D011247:Pregnancy; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
D016207:Cytokines; D014157:Transcription Factors