A new furofuran lignan with antioxidant and antiseizure activities from the leaves of Petasites japonicus.
A new furofuran lignan (1) was isolated from the n-butanol fraction of the methanolic extract of the leaves of Petasites japonicus (Sieb. et Zucc.) Maxim. (Compositae). The structure of compound 1 was determined to be 2alpha-(4'-hydroxy-3'-methoxyphenyl)-6alpha-(4"-hydroxy-3"-methoxyphenyl)-8alpha-hydroxy-3,7-dioxabicyclo[3.3.0octane 4'-O-(beta-D-glucopyranoside) by spectroscopic methods including 2D-NMR. In further studies, it was found that the compound 1 expressed an antioxidant activity in DPPH radical scavenging assay, and moreover, ameliorated the seizure in kainic acid-treated mice.
Min
Byung-Sun
BS
College of Pharmacy, Catholic University of Daegu, Gyongbook 712-702, Korea.
Cui
Hui Song
HS
Lee
Hyeong-Kyu
HK
Sok
Dai-Eun
DE
Kim
Mee Ree
MR
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D036901:Petasites / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*
D000927:Anticonvulsants; D000975:Antioxidants; D017705:Lignans