High-resolution real-time spiral MRI for guiding vascular interventions in a rabbit model at 1.5 T.
OBJECTIVE
To study the feasibility of a combined high spatial and temporal resolution real-time spiral MRI sequence for guiding coronary-sized vascular interventions.


METHODS
Eight New Zealand White rabbits (four normal and four with a surgically-created stenosis in the abdominal aorta) were studied. A real-time interactive spiral MRI sequence combining 1.1 x 1.1 mm(2) in-plane resolution and 189-msec total image acquisition time was used to image all phases of an interventional procedure (i.e., guidewire placement, balloon angioplasty, and stenting) in the rabbit aorta using coronary-sized devices on a 1.5 T MRI system.


RESULTS
Real-time spiral MRI identified all rabbit aortic stenoses and provided high-temporal-resolution visualization of guide-wires crossing the stenoses in all animals. Angioplasty balloon dilatation and deployment of coronary-sized copper stents in the rabbit aorta were also successfully imaged by real-time spiral MRI.


CONCLUSIONS
Combining high spatial and temporal resolution with spiral MRI allows real-time MR-guided vascular intervention using coronary-sized devices in a rabbit model. This is a promising approach for guiding coronary interventions.
Terashima
Masahiro
M
Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305-5233, USA.
Hyon
MinSu
M
de la Pena-Almaguer
Erasmo
E
Yang
Phillip C
PC
Hu
Bob S
BS
Nayak
Krishna S
KS
Pauly
John M
JM
McConnell
Michael V
MV
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000473:pathology* / Q000601:surgery*; D001185:Artificial Intelligence; D003199:Computer Systems; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014656:Vascular Surgical Procedures / Q000379:methods*