Effect of GB virus C viremia on HIV acquisition and HIV set-point.
We performed both a case-control study and a cohort study to determine whether GB virus C (GBV-C) viremia prevents the acquisition of HIV infection or alters the HIV set-point after infection. The prevalence of GBV-C viremia in HIV-uninfected individuals who did and did not acquire HIV were similar (odds ratio 1.32; 95% confidence interval 0.6-2.6). Pre-existing GBV-C viremia at the time of HIV acquisition was also not associated with lower plasma HIV-RNA levels.
Bisson
Gregory P
GP
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Strom
Brian L
BL
Gross
Robert
R
Weissman
Drew
D
Klinzman
Donna
D
Hwang
Wei-Ting
WT
Kostman
Jay R
JR
Metzger
David
D
Stapleton
Jack T
JT
Frank
Ian
I
D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications / Q000821:virology*; D029407:GB virus C; D006678:HIV / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000821:virology*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000821:virology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D014766:Viremia / Q000150:complications / Q000821:virology*
D012367:RNA, Viral