title: Dengue virus type 3, Brazil, 2002.
abstract: During the summer of 2002, Rio de Janeiro had a large epidemic of dengue fever; 288,245 cases were reported. A subset of 1,831 dengue hemorrhagic fever cases occurred. In this study, performed in the first half of 2002, samples from 1,559 patients with suspected cases of dengue infection were analyzed. From this total, 1,497 were obtained from patients with nonfatal cases, and 62 were obtained from patients with fatal cases. By the use of different methods, 831 (53.3%) cases, including 40 fatal cases, were confirmed as dengue infection. When virus identification was successful, dengue virus type 3 (DENV-3) was obtained in 99% of cases. Neurologic involvement was shown in 1 patient with encephalitis, confirmed by the detection of DENV-3 RNA in the cerebrospinal fluid. This explosive epidemic of DENV-3 was the most severe dengue epidemic reported in Brazil since dengue viruses were introduced in 1986.
authors.affiliation: Departamento de Virologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil. rita@ioc.fiocruz.br
authors.forename: Rita Maria Ribeiro
authors.initials: RM
authors.lastname: Nogueira
authors.forename: Hermann Gonçalves
authors.initials: HG
authors.lastname: Schatzmayr
authors.forename: Ana Maria Bispo
authors.initials: AM
authors.lastname: de Filippis
authors.forename: Flávia Barreto
authors.initials: FB
authors.lastname: dos Santos
authors.forename: Rivaldo Venâncio
authors.initials: RV
authors.lastname: da Cunha
authors.forename: Janice Oliveira
authors.initials: JO
authors.lastname: Coelho
authors.forename: Luiz José
authors.initials: LJ
authors.lastname: de Souza
authors.forename: Flávia Ramos
authors.initials: FR
authors.lastname: Guimarães
authors.forename: Eliane Saraiva Machado
authors.initials: ES
authors.lastname: de Araújo
authors.forename: Thatiane Santos
authors.initials: TS
authors.lastname: De Simone
authors.forename: Meri
authors.initials: M
authors.lastname: Baran
authors.forename: Gualberto
authors.initials: G
authors.lastname: Teixeira
authors.forename: Marize Pereira
authors.initials: MP
authors.lastname: Miagostovich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003715:Dengue / Q000453:epidemiology* / Q000401:mortality / Q000821:virology; D003716:Dengue Virus / Q000145:classification / Q000302:isolation & purification*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D012699:Serology
chemical_list: D012367:RNA, Viral