title: Cytogenetic aspects of buprenorphine maintenance treatment program--preliminary report.
abstract: The study was aimed at a preliminary evaluation of the effect of buprenorphine, a synthetic opioid used as a substitute in the therapy of dependence on psychoactive substances, on the structure of the genetic material of patients receiving such treatment. The material for the study were lymphocyte cultures from peripheral blood, analysed by a cytogenetic micronuclear test. The obtained results were compared with the literature data on the mutagenic action of methadone.
authors.affiliation: Department of Anthropology, Institute of Zoology, Jagiellonian University, Kaków, Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Piatek
authors.forename: Dorota
authors.initials: D
authors.lastname: Pach
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kamenczak
authors.forename: Jan
authors.initials: J
authors.lastname: Schmager
mesh_terms: D000328:Adult; D002047:Buprenorphine / Q000494:pharmacology*; D005260:Female; D005819:Genetic Markers / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008691:Methadone / Q000494:pharmacology*; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced / Q000187:drug effects*; D015162:Micronucleus Tests; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000097:blood / Q000235:genetics* / Q000534:rehabilitation*; D011044:Poland
chemical_list: D005819:Genetic Markers; D009292:Narcotic Antagonists; D009294:Narcotics; D002047:Buprenorphine; D008691:Methadone