[Comparison of Rhesus boxes in Hans and Uighurs].
OBJECTIVE
To study the difference and similarity between Hans and Uighurs in regard to Rhesus box and its significance.


METHODS
The sequence specific primers of upstream, downstream and hybrid Rhesus boxes were designed on the basis of RHD gene sequence. The upstream, downstream and hybrid Rhesus boxes were determined by polymerase chain reaction-sequence specific primer(PCP-SSP) and mismatched PCR.


RESULTS
The percentage of RHD-/RHD-, RHD+/RHD- and RHD+/RHD+ genotypes ascertained in the unrelated Hans with RhD(-) were 61.40%, 34.21% and 4.39% respectively, while those in the unrelated Chinese Uighurs with RhD(-) were 94.44%, 2.78% and 2.78% respectively. Furthermore, all 6 cases of some other minorities were RHD-/RHD- types. The percentage of RHD-/RHD- and RHD+/RHD- genotypes ascertained in the unrelated Chinese Uighurs were significantly higher than those in Chinese Hans (P < 0.01), whereas no statistically significant difference in the percentage of RHD+/RDH+ genotype between the two groups was observed (P > 0.05).


CONCLUSIONS
The Rh blood group of Uighurs in Xingjiang possesses both Oriental and Caucasian characteristics, which embodies a special ethnical aspect of the Chinese nation and is in accord with the anthropologic research results.
Lan
Jiong-cai
JC
Nanfang Hospital, First Military Medical University, Guangzhou, Guangdong, PR China.
Zhou
Hua-you
HY
Bai
Xu-hua
XH
Pang
Gui-zhi
GZ
Wang
Xiao-zhu
XZ
Cai
Ling-jun
LJ
Cao
Qiong
Q
Zhang
Yin-ze
YZ
Xia
Rong
R
Yang
Quan-ke
QK
D002681:China; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D012204:Rh-Hr Blood-Group System