title: Obsessive-compulsive disorder patients display enhanced latent inhibition on a visual search task.
abstract: Latent inhibition (LI) is a phenomenon that reflects the ability to ignore irrelevant stimuli. LI is attenuated in some schizophrenic patient groups and in high schizotypal normal participants. One study has found enhanced LI in patients with obsessive-compulsive disorder (OCD [Swerdlow, N. R., Hartston, H. J., & Hartman, P. L., 1999. Enhanced visual latent inhibition in obsessive-compulsive disorder. Biological Psychiatry, 45, 482-488]). The present experiment replicated this finding using a within-subject visual search LI task, with OCD patients displaying more LI than healthy controls. The contrasting LI effects in schizophrenia and OCD are discussed in terms of how these groups differentially process relevant and irrelevant stimuli, and how that outcome affects subsequent behavior.
authors.affiliation: The College of Management, Rishon Le Zion, Israel.
authors.forename: Oren
authors.initials: O
authors.lastname: Kaplan
authors.forename: Reuven
authors.initials: R
authors.lastname: Dar
authors.forename: Lirona
authors.initials: L
authors.lastname: Rosenthal
authors.forename: Haggai
authors.initials: H
authors.lastname: Hermesh
authors.forename: Mendel
authors.initials: M
authors.lastname: Fux
authors.forename: R E
authors.initials: RE
authors.lastname: Lubow
mesh_terms: D000328:Adult; D005260:Female; D005364:Field Dependence-Independence; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D010364:Pattern Recognition, Visual; D010775:Photic Stimulation / Q000379:methods; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics