title: Significance of the relationship between irregular regeneration and two hepatocarcinogenic pathways: "de novo" and so-called "dysplastic nodule-hepatocellular carcinoma" sequence.
abstract: OBJECTIVE
  Irregular regeneration of hepatocytes has been reported as an important factor in the hepatocarcinogenesis, so we studied the relationship between irregular regeneration and two hepatocarcinogenic pathways, "de novo" and "dysplastic nodule-hepatocellular carcinoma sequence."
  
  
  METHODS
  Liver tissue was obtained from surgically resected 112 specimens, early well differentiated hepatocellular carcinomas and non-cancerous tissue. Hepatocellular carcinomas were divided into two groups; carcinoma with dysplastic area (type A) and without dysplastic area (type B) and were compared with irregular regeneration of hepatocytes in the non-cancerous tissue.
  
  
  RESULTS
  Eighty-eight of 112 cases were judged to have irregular regeneration, such as anisocytosis, pleomorphism, bulging and map-like distribution. The degree of irregular regeneration was not correlated to the type of early well differentiated hepatocellular carcinomas. However, the existence of pleomorphism, map-like distribution and bulging are significantly correlated with type A.
  
  
  CONCLUSIONS
  Type A might be more frequently occurring in a carcinogenic liver showing some kinds of irregular regeneration.
authors.affiliation: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Taguchi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Shuji
authors.initials: S
authors.lastname: Matsuura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Terashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000473:pathology*; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D022781:Hepatocytes / Q000502:physiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology*; D008115:Liver Regeneration; D011230:Precancerous Conditions / Q000473:pathology