Animal models of leptomeningeal cancer.
Animal models are a critical tool for our understanding of pathogenic mechanisms and the development of therapeutic strategies. Since the 1970's, numerous syngeneic and allogeneic rodent models of leptomeningeal cancer have been developed; in this chapter, we present representative models and discuss their clinical and translational implications.
Raja
Ali
A
University of Illinois at Chicago, Chicago, IL 60612, USA.
Engelhard
Herbert H
HH
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology*; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D014183:Transplantation, Heterologous