Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis.
This databank-based, multicenter study compared all stroke patients with IV tissue plasminogen activator aged > or = 80 years (n = 38) and those < 80 years old (n = 287). Three-month mortality was higher in older patients. Favorable outcome (modified Rankin scale < or = 1) and intracranial hemorrhage (asymptomatic/symptomatic/fatal) were similarly frequent in both groups. Logistic regression showed that stroke severity, time to thrombolysis, glucose level, and history of coronary heart disease independently predicted outcome, whereas age did not.
Engelter
S T
ST
Departments of Neurology, University Hospital Basel, CH-4031 Basel, Switzerland. sengelter@uhbs.ch
Reichhart
M
M
Sekoranja
L
L
Georgiadis
D
D
Baumann
A
A
Weder
B
B
Müller
F
F
Lüthy
R
R
Arnold
M
M
Michel
P
P
Mattle
H P
HP
Tettenborn
B
B
Hungerbühler
H J
HJ
Baumgartner
R W
RW
Sztajzel
R
R
Bogousslavsky
J
J
Lyrer
P A
PA
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000502:physiology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000592:standards / Q000706:statistics & numerical data; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000453:epidemiology; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D009026:Mortality / Q000639:trends; D018579:Patient Selection; D020521:Stroke / Q000188:drug therapy* / Q000401:mortality* / Q000503:physiopathology; D013557:Switzerland / Q000453:epidemiology; D015912:Thrombolytic Therapy / Q000592:standards / Q000706:statistics & numerical data*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D001786:Blood Glucose; D010959:Tissue Plasminogen Activator