title: Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains.
abstract: Two genes recently associated with glycopeptide intermediate resistance in Staphylococcus aureus (GISA) are mprF and tcaA, with inactivation causing shifts in vancomycin resistance. This study reveals that expression levels of both genes are similar in groups of clinical GISA, heteroGISA and glycopeptide susceptible strains, suggesting no association with clinical isolates.
authors.affiliation: Department of Pathology and Microbiology, Bristol Centre for Antimicrobial Research and Evaluation, Medical Sciences, University of Bristol, and North Bristol Healthcare Trust, Southmead Hospital, Bristol, UK. mandy.wootton@bristol.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Wootton
authors.forename: A P
authors.initials: AP
authors.lastname: Macgowan
authors.forename: T R
authors.initials: TR
authors.lastname: Walsh
mesh_terms: D019881:Aminoacyltransferases; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D020713:Vancomycin Resistance
chemical_list: D001426:Bacterial Proteins; D019881:Aminoacyltransferases; C429146:mprF protein, Staphylococcus aureus