[Association between expression of survivin and high-risk human papillomavirus infection in cervical cancer and precancerous tissues].
OBJECTIVE
To investigate the expression of survivin and its association with high-risk human papillomavirus (HPV) infection in cervical cancer and precancerous tissues.


METHODS
In 76 patients with cervical intraepithelial neoplasia (CIN) or cervical carcinoma, the expression of survivin was detected by immunohistochemistry and the infection rates of high-risk HPV including HPV16, 18, 31, 33, 52, and 58 were assayed by touch-down PCR, with 10 cases of normal cervical specimens serving as the control.


RESULTS
Survivin expression tended to increase along with the tumor progression (P<0.05), and was associated with the histological grade of invasive carcinoma (P<0.05) but not with the patients' age, clinical stage or histological classification (P>0.05). The positivity rate of high-risk HPV increased only in association with tumor progression (P<0.05) but not with the patients' age, clinical stage or histological classification (P>0.05). Positive correlation between the expression of survivin and high-risk HPV infection was observed in cervical carcinoma.


CONCLUSIONS
Survivin might play an important role in the occurrence and development of cervical carcinoma in coordination with high-risk HPV.
Lang
Yan
Y
Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan 430010, China. babyjulialang@126.com
Xiong
Yong-yan
YY
Chen
Hui-zhen
HZ
D017209:Apoptosis / Q000235:genetics*; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000302:isolation & purification; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D030361:Papillomavirus Infections / Q000235:genetics* / Q000378:metabolism; D011230:Precancerous Conditions / Q000378:metabolism / Q000821:virology; D000077022:Survivin; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000821:virology*
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin