title: Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients.
abstract: The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. GCT patients with metastatic disease were more likely to have a variant type allele of the polymorphisms at codon 5 (age-adjusted odds ratio (aOR)=6.25; 95% CI=1.09-35.83; P=0.040) and codon 8 (aOR=4.63; 95% CI=1.35-15.93; P=0.015) than those with the localized disease. Therefore, BCL10 polymorphisms at codons 5 and 8 may play a role in the progression to advanced stage GCTs.
authors.affiliation: Department of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Inoue
authors.forename: Takuo
authors.initials: T
authors.lastname: Ito
authors.forename: Shintaro
authors.initials: S
authors.lastname: Narita
authors.forename: Yohei
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Norihiko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakinuma
authors.forename: Mutsuki
authors.initials: M
authors.lastname: Mishina
authors.forename: Eijiro
authors.initials: E
authors.lastname: Nakamura
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kato
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000328:Adult; D000074018:B-Cell CLL-Lymphoma 10 Protein; D002878:Chromosomes, Human, Pair 1; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human