Novel transdermal drug delivery system with polyhydroxyalkanoate and starburst polyamidoamine dendrimer.
In search of an efficient transdermal drug delivery system (TDDS), a polyhydroxyalkanoate (PHA)-based system with a polyamidoamine dendrimer was examined. Tamsulosin was used as the model drug. The dendrimer was found to act as the weak enhancer. By adding the dendrimer, the dendrimer-containing PHA matrix achieved the clinically required amount of tamsulosin permeating through the skin model. This is also the first report of the application of PHA and dendrimer to the TDDS.
Wang
Zhioxiong
Z
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita 565-0871, Japan.
Itoh
Yoshiaki
Y
Hosaka
Yoshifumi
Y
Kobayashi
Ichiro
I
Nakano
Yoshihisa
Y
Maeda
Isamu
I
Umeda
Fusako
F
Yamakawa
Junji
J
Kawase
Masaya
M
Yag
Kiyohito
K