Tracking thymocyte migration in situ.
The dynamic process of thymocyte migration can now be visualized in real-time and in the context of the native thymic environment. With improved computational resources, key information can be extracted from real-time imaging data and the migratory behaviors of developing thymocytes can be quantitated. The extraction and exploitation of three dimensional data through time is providing new insight into the nature and regulation of intrathymic migration. In this review we discuss this interdisciplinary approach and the promise it holds for the study of thymocyte migration in situ.
Witt
Colleen M
CM
Division of Immunology, Department of Molecular and Cell Biology, 479 Life Sciences Addition, University of California, Berkeley, CA 94720, USA. colleen.witt@utsa.edu
Robbins
Kay
K
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology