title: Bivariate isotonic design for dose-finding with ordered groups.
abstract: We consider the problem of dose-finding where subjects can be stratified into two populations with possibly different susceptibility to toxicity. The goal is to find the maximally tolerated dose for each population. We propose a non-parametric design for this problem. Toxicity is estimated using the bivariate isotonic regression estimator. The new design is compared with the two-sample continual reassessment method.
authors.affiliation: Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7420, USA. aivanova@bios.unc.edu
authors.forename: Anastasia
authors.initials: A
authors.lastname: Ivanova
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D006801:Humans; D020714:Maximum Tolerated Dose; D015999:Multivariate Analysis; D018709:Statistics, Nonparametric