Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient.
We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.
Humpert
P M
PM
Department of Medicine I, University Clinics Heidelberg, Germany. per.humpert@med.uni-heidelberg.de
Bärtsch
U
U
Konrade
I
I
Hammes
H-P
HP
Morcos
M
M
Kasper
M
M
Bierhaus
A
A
Nawroth
P P
PP
D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology; D017719:Diabetic Foot / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D018919:Neovascularization, Physiologic; D020127:Recovery of Function; D014182:Transplantation, Autologous; D014945:Wound Healing