title: Serum Müllerian-inhibiting substance levels in adolescent girls with normal menstrual cycles or with polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare serum müllerian-inhibiting substance (MIS) concentrations in adolescent girls with polycystic ovary syndrome (PCOS) or normal menstrual cycles.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University department of obstetrics and gynecology.
  
  
  METHODS
  Thirty-one girls (12-18 years old) with PCOS and 17 girls (12-19 years old) with normal menstrual cycles.
  
  
  METHODS
  Serum was collected from girls with PCOS or normal cycles during the early follicular phase of the menstrual cycle, stored frozen until assayed.
  
  
  METHODS
  Serum levels of MIS, E2, free-T, androstenedione, LH, and FSH.
  
  
  RESULTS
  Serum MIS levels in girls with PCOS were significantly higher compared with normal girls (4.1 +/- 2.2 [SD] and 2.4 +/- 1.0 ng/mL, respectively). The subjects were stratified for body mass index (BMI) (< and >25 kg/m2). Serum MIS levels in PCOS girls (4.2 +/- 3.0 ng/mL [BMI <25 kg/m2] and 4.0 +/- 1.6 [BMI >25 kg/m2]) were significantly higher compared with normal girls (2.2 +/- 0.8 and 2.6 +/- 0.7 ng/mL, respectively).
  
  
  CONCLUSIONS
  Adolescent girls with PCOS have significantly higher serum MIS levels compared with normally cycling girls. Serum MIS levels in PCOS were not influenced by BMI. Increased MIS production may represent an early manifestation of the disease.
authors.affiliation: Department of Surgery, University of Louisville, Louisville, Kentucky, USA. ysiow@louisville.edu
authors.forename: Yong
authors.initials: Y
authors.lastname: Siow
authors.forename: Sari
authors.initials: S
authors.lastname: Kives
authors.forename: Paige
authors.initials: P
authors.lastname: Hertweck
authors.forename: Sally
authors.initials: S
authors.lastname: Perlman
authors.forename: Mary E
authors.initials: ME
authors.lastname: Fallat
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone; D015415:Biomarkers / Q000097:blood; D002648:Child; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood*; D009095:Mullerian Ducts / Q000473:pathology / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology; D011446:Prospective Studies; D013735:Testicular Hormones / Q000097:blood*; D013781:Texas
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone