[Level and heritability analysis of serum apoA I and apoB100 in twins].
OBJECTIVE
To describe the serum level of apoA I and apoB100 in twins, and study the contribution of genetic and environmental effects to them.


METHODS
The researchers used immunoturbidimetric assay (ITA) for quantification of the serum apoA I and apoB100 in 329 monozygotic (MZ) and 173 dizygotic (DZ) twins identified by genotyping. Mx was used to fit a variety of genetic models covering age and sex for the variation of apoA I and apoB100.


RESULTS
The serum levels were (1.33+/-0.23) g/L for apoA I and (0.75+/-0.19) g/L for apoB100. Model AES fitted apoA I data best and scalar effects sex-limitation model AE fitted apoB100 best. 60% of the variance in apoA I was due to additive effects and 69% in apoB100.


CONCLUSIONS
The heritability of apoA I and apoB100 in this twin study was 60% and 69%.
Gao
Wen-jing
WJ
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China.
Li
Li-ming
LM
Cao
Wei-hua
WH
Lv
Jun
J
Qin
Ying
Y
Chen
Wei-jian
WJ
Chen
Rong-Fu
RF
Hu
Yong-hua
YH
D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood* / Q000235:genetics*; D053299:Apolipoprotein B-100 / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics
D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100