[The influence of new hybrid antioxidants ichphans on the kinetics of ascorbate-induced reduction of spin probe radical centers in liposomes].
The influence of new hybrid antioxidants ichphans on the structure of liposome lipid bilayer was studied. The analysis of the kinetics of the ascorbate-induced reduction of spin probe radical centers incorporated in a membrane revealed that ichphans produce a modifying effect on the structure of liposome membrane. It was established that derivates with distinct hydrophobic properties transform different sites of the membrane that are the sites of localization of ichphans in the intramembraneous space. The data obtained suggest that lipid components play an important role in the effects of ichphans on biological membranes.
Parshina
E Iu
EIu
Gendel'
L Ia
LIa
Rubin
A B
AB
D000975:Antioxidants / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013113:Spin Labels
D000975:Antioxidants; D008051:Lipid Bilayers; D008081:Liposomes; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D013113:Spin Labels; D001205:Ascorbic Acid