title: Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report.
abstract: Primary lymphoma of the central nervous system (PCNSL) is extremely rare, especially in childhood. A 9-year-old Japanese boy was diagnosed as having precursor-B cell-type lymphoblastic lymphoma, based on morphologic and immunocytochemical analysis of mononuclear cells in the cerebrospinal fluid and a positive reaction for terminal deoxynucleotidyl transferase (TdT), CD19, CD79a, and CD179b. After seven courses of chemotherapy and craniospinal radiotherapy, the patient is alive, well, and in continuous complete remission. Despite its rarity, PCNSL should be included in the differential diagnosis in the presence of symptoms of increased intracranial pressure and/or unusual imaging findings of the brain.
authors.affiliation: Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan. y-shio@mte.biglobe.ne.jp
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shiozawa
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kiyokawa
authors.forename: Junya
authors.initials: J
authors.lastname: Fujimura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yarita
authors.forename: Junichiro
authors.initials: J
authors.lastname: Fujimoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamashiro
mesh_terms: D015703:Antigens, CD / Q000134:cerebrospinal fluid; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D002648:Child; D004253:DNA Nucleotidylexotransferase / Q000134:cerebrospinal fluid; D006801:Humans; D007121:Immunocompetence; D016393:Lymphoma, B-Cell / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D015703:Antigens, CD; D004253:DNA Nucleotidylexotransferase