title: Renewal processes and fluctuation analysis of molecular motor stepping.
abstract: We present a systematic method of analysis of experiments performed with single motor proteins. The use of such a method should allow a more detailed description of the motor's chemical cycle through the precise fitting of the experimental data. We model the dynamics of a processive or rotary molecular motor using a renewal process, in line with the work initiated by Svoboda, Mitra and Block. We apply a functional technique to compute different types of multiple-time correlation function of the renewal process, which have applications to bead-assay experiments performed both with processive molecular motors, such as myosin V and kinesin, and rotary motors, such as F1-ATPase.
authors.affiliation: Hahn-Meitner Institut, Abteilung Theorie, Glienicker Str. 100, D-14109 Berlin, Germany.
authors.forename: Jaime E
authors.initials: JE
authors.lastname: Santos
authors.forename: Thomas
authors.initials: T
authors.lastname: Franosch
authors.forename: Andrea
authors.initials: A
authors.lastname: Parmeggiani
authors.forename: Erwin
authors.initials: E
authors.lastname: Frey
mesh_terms: D016547:Kinesins / Q000737:chemistry; D008956:Models, Chemical; D020409:Molecular Motor Proteins; D024701:Myosin Type V / Q000737:chemistry; D006180:Proton-Translocating ATPases / Q000737:chemistry
chemical_list: D020409:Molecular Motor Proteins; D024701:Myosin Type V; D006180:Proton-Translocating ATPases; D016547:Kinesins