title: [Treatment of Hailey-Hailey disease with carbon dioxide laser vaporization].
abstract: BACKGROUND
  Only ablative methods lead to long term remission of areas affected by Hailey-Hailey disease: excision/skin graft, cryosurgery, dermabrasion... The method using the CO2 laser is a recent addition in the management of this dermatitis. We report our experience with this technique in 4 patients.
  
  
  METHODS
  Carbon dioxide laser vaporization was proposed to 4 patients exhibiting Hailey-Hailey disease resistant to classical treatments. A test under local anesthesia was performed beforehand in all the patients. A 60 year-old man had an immediate reaction and refused to continue treatment. In the other 3 cases, the result of the test at 6 months was considered satisfactory. These patients were treated under general anesthesia in a single area of 50 to 70 cm2, and a half-body for comparison. The CO2 laser was used in pulse mode, with successive irradiations, until a homogenous, whitish-yellow aspect with first retraction was obtained.
  
  
  RESULTS
  Although the healing delays were long (a mean of 1 month) and required major analgesics over the first few days, the cosmetic results were satisfactory and no abnormal scarring was observed. After a median follow-up of 27 months, no relapse of the disease other than punctiform elements was noted. All the patients wanted treatment of the other remaining affected areas be continued. In 2 patients, CO2 laser vaporization permitted treatment of areas not easily accessible to other ablative methods (around the mouth, the anus and the vulva) with anatomy and normal function spared.
  
  
  CONCLUSIONS
  These results are globally good. Although the time to healing was long, the cosmetic and functional results were always satisfactory, without abnormal scarring. Moreover, in 2 of the patients, CO2 laser was able to treat areas inaccessible to other methods. The reason for the efficacy of ablative methods is debated. Re-epidermization with keratinocytes of appendices and not expressing the molecular defect, and the constitution of dermal cicatricial tissue, are two currently proposed hypotheses.
authors.affiliation: Service de Dermatologie, Hôpital Sainte-Marguerite, Marseille.
authors.forename: A-M
authors.initials: AM
authors.lastname: Collet Villette
authors.forename: M-A
authors.initials: MA
authors.lastname: Richard
authors.forename: F
authors.initials: F
authors.lastname: Fourquet
authors.forename: S
authors.initials: S
authors.lastname: Monestier
authors.forename: C
authors.initials: C
authors.lastname: Gaudy
authors.forename: J-J
authors.initials: JJ
authors.lastname: Bonerandi
authors.forename: J-J
authors.initials: JJ
authors.lastname: Grob
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D000772:Anesthesia, Local; D002245:Carbon Dioxide; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D016506:Pemphigus, Benign Familial / Q000601:surgery*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide