title: Physiological reactions of primates to 9-D immersion and head-down tilt.
abstract: Purpose of the investigation was to compare physiological reactions of primates (Macaca mulatta) to microgravity simulated by immersion and head-down tilt (HDT). In immersion experiments, primates in waterproof suits were put into motion-restraining chairs and immersed into water (t=35.4 degrees C) breast-deep for 9 days. In 9-d HDT experiments, prone primates were motor restrained in dedicated tilt beds at -5 degrees. It was found that the CNS functioning was significantly affected, the plasma volume reduced and the marrow erythropoietic function declined. Atrophy developed in leg muscles on a backdrop of iliopectineal spongy osteopenia. Loss in hydration, inhibition of erythropoietic hemopoiesis and iliopectineal spongy osteopenia were more pronounced following immersion than HDT.
authors.affiliation: SRC Institute of Biomedical Problems, Moscow, Russia. 1162@imbp.ru
authors.forename: V I
authors.initials: VI
authors.lastname: Korolkov
authors.forename: V P
authors.initials: VP
authors.lastname: Krokotov
authors.forename: Yu V
authors.initials: YV
authors.lastname: Gordeev
authors.forename: A O
authors.initials: AO
authors.lastname: Lazarev
authors.forename: V
authors.initials: V
authors.lastname: Lobachik
authors.forename: T E
authors.initials: TE
authors.lastname: Burkovskaya
authors.forename: M A
authors.initials: MA
authors.lastname: Dotsenko
authors.forename: G N
authors.initials: GN
authors.lastname: Durnova
authors.forename: A S
authors.initials: AS
authors.lastname: Kaplansky
authors.forename: I N
authors.initials: IN
authors.lastname: Chistiakov
authors.forename: O N
authors.initials: ON
authors.lastname: Vasilieva
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D001826:Body Fluids / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000503:physiopathology; D002490:Central Nervous System / Q000502:physiology*; D003213:Conditioning, Psychological; D004920:Erythropoiesis / Q000502:physiology; D018475:Head-Down Tilt; D018476:Hypokinesia / Q000503:physiopathology; D007101:Immersion / Q000503:physiopathology*; D007866:Leg; D008253:Macaca mulatta; D009133:Muscular Atrophy / Q000209:etiology / Q000503:physiopathology; D010953:Plasma Volume / Q000502:physiology; D012149:Restraint, Physical; D013312:Stress, Physiological; D018474:Weightlessness Simulation