title: New drug delivery for corneal neovascularization using polyion complex micelles.
abstract: OBJECTIVE
  To introduce photodynamic therapy (PDT) for corneal neovascularization (NV) by polyion complex (PIC) micelles, a novel drug delivery system.
  
  
  RESULTS
  Development of specific drug delivery systems to corneal NV sites is an important part of next-generation photodynamic therapy. Nanocarriers consisting of PIC micelles bound by polyethylene glycol (PEG) shell exhibit good stability, high drug-loading capacity, and excellent potential for controlled drug release. Encapsulation of the photosensitizer dendrimer porphyrin (DP) into PIC micelles (DP-micelles) conveys adequate stability and increased photocytotoxicity without compromising photophysical properties of DP stability. We assessed the accumulation of DP-micelles and observed that the DP-micelles were incorporated into the corneal NV area.
  
  
  CONCLUSIONS
  PIC micelles possess attractive features of selective accumulation at the corneal NV site. PDT using DP-micelles appears to be effective and safe for the treatment of corneal NV.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. tomohiko-tky@umin.ac.jp
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Usui
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugisaki
authors.forename: Shiro
authors.initials: S
authors.lastname: Amano
authors.forename: Woo-Dong
authors.initials: WD
authors.lastname: Jang
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishiyama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000818:Animals; D016510:Corneal Neovascularization / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000639:trends; D007477:Ions; D008823:Micelles; D049329:Nanostructures; D010778:Photochemotherapy / Q000379:methods
chemical_list: D007477:Ions; D008823:Micelles