title: Association between genital tract cytomegalovirus infection and bacterial vaginosis.
abstract: Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.
authors.affiliation: Department of Pediatrics, University of Alabama at Birmingham, 35233, USA. sross@peds.uab.edu
authors.forename: Shannon A
authors.initials: SA
authors.lastname: Ross
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Novak
authors.forename: Guha
authors.initials: G
authors.lastname: Ashrith
authors.forename: Lisa B
authors.initials: LB
authors.lastname: Rivera
authors.forename: William J
authors.initials: WJ
authors.lastname: Britt
authors.forename: Spencer
authors.initials: S
authors.lastname: Hedges
authors.forename: Jane R
authors.initials: JR
authors.lastname: Schwebke
authors.forename: And Suresh
authors.initials: AS
authors.lastname: Boppana
mesh_terms: D000328:Adult; D003587:Cytomegalovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D014621:Vagina / Q000821:virology*; D016585:Vaginosis, Bacterial / Q000150:complications* / Q000453:epidemiology; D014759:Viral Envelope Proteins / Q000235:genetics; D017201:Virus Shedding
chemical_list: D004279:DNA, Viral; D014759:Viral Envelope Proteins; C417883:glycoprotein N, Human cytomegalovirus