Time-course of vibratory adaptation and recovery in cutaneous mechanoreceptive afferents.
Extended suprathreshold vibratory stimulation applied to the skin results in a desensitization of cutaneous mechanoreceptive afferents. In a companion paper, we describe the dependence of the threshold shift on the parameters of the adapting stimulus and discuss neural mechanisms underlying afferent adaptation. Here we describe the time-course of afferent adaptation and recovery. We found that absolute and entrainment thresholds rise and fall exponentially during adaptation and recovery with time constants that vary with fiber type. slowly adapting type I (SA1) afferents adapt most rapidly, and pacinian (PC) afferents adapt most slowly, whereas rapidly adapting (RA) afferents exhibit intermediate rates of adaptation; SA1 fibers also recover more rapidly from adaptation than RA and PC fibers. We also showed that threshold adaptation is accompanied by a shift in the timing of the spikes within individual cycles of the adapting stimulus (i.e., a shift in the impulse phase). We invoked an integrate-and-fire model to explore possible mechanisms underlying afferent adaptation. Finally, we found that the time-course of afferent adaptation is more rapid than that of its psychophysical counterpart, as is the time-course of recovery from adaptation, suggesting that central factors play a role in the psychophysical phenomenon.
Leung
Y Y
YY
Krieger Mind/Brain Institute, Baltimore, MD 21218, USA.
Bensmaïa
S J
SJ
Hsiao
S S
SS
Johnson
K O
KO
D000200:Action Potentials / Q000502:physiology; D000222:Adaptation, Physiological / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D007700:Kinetics; D008253:Macaca mulatta; D008465:Mechanoreceptors / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008959:Models, Neurological; D010812:Physical Stimulation / Q000379:methods; D012867:Skin / Q000294:innervation*; D012879:Skin Physiological Phenomena; D013997:Time Factors; D014110:Touch / Q000502:physiology*; D014732:Vibration