title: 11C-methionine PET for the diagnosis and management of recurrent pituitary adenomas.
abstract: OBJECTIVE
  The detection of recurrent pituitary adenoma by magnetic resonance imaging (MRI) is rendered uncertain by the tissue remodelling that follows surgery or radiotherapy. We aimed to evaluate the contribution of PET with 11C-methionine (MET-PET) in the detection and management of recurrent pituitary adenoma.
  
  
  METHODS
  Thirty-three patients with pituitary adenoma were evaluated postoperatively by MET-PET, either because of biological evidence of active residual tumour or because of MRI demonstration of non-functional adenoma growth. We studied 24 secreting adenomas and nine non-functional adenomas.
  
  
  RESULTS
  In 30 patients, MET-PET detected abnormally hypermetabolic tissue. In 14 out of these, MRI did not differentiate between residual tumour and scar formation. In nine of these 14 cases, major therapeutic decisions were undertaken (radiosurgery and surgery). In another group of 16 patients, both MET-PET and MRI detected abnormal tissue. In one case, neither MRI nor MET-PET detected adenomatous tissue. Finally, abnormal tissue was detected in two patients on MRI solely. In these two cases, failure of MET-PET to reveal the adenoma was attributable to concomitant inhibitory therapy. The sensitivity of MET-PET and MRI varied as a function of the tumour type: all non-functional adenomas were localised by both modalities, while MET-PET detected all adrenocorticotropic hormone-secreting adenomas whereas MRI depicted only one of these eight lesions. Fifteen out of 17 patients treated by radiosurgery showed clinical improvement after treatment.
  
  
  CONCLUSIONS
  We suggest that MET-PET is a sensitive technique complementary to MRI for the detection of residual or recurrent pituitary adenomas. It should gain a place in the efficient management of these tumours.
authors.affiliation: PET-Biomedical Cyclotron Unit and Department of Nuclear Medicine, Université Libre de Bruxelles, Erasme Hospital, Brussels, Belgium. Thanh.Tang@ulb.ac.be
authors.forename: B N T
authors.initials: BN
authors.lastname: Tang
authors.forename: M
authors.initials: M
authors.lastname: Levivier
authors.forename: M
authors.initials: M
authors.lastname: Heureux
authors.forename: D
authors.initials: D
authors.lastname: Wikler
authors.forename: N
authors.initials: N
authors.lastname: Massager
authors.forename: D
authors.initials: D
authors.lastname: Devriendt
authors.forename: P
authors.initials: P
authors.lastname: David
authors.forename: N
authors.initials: N
authors.lastname: Dumarey
authors.forename: B
authors.initials: B
authors.lastname: Corvilain
authors.forename: S
authors.initials: S
authors.lastname: Goldman
mesh_terms: D000328:Adult; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008715:Methionine; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods*; D012008:Recurrence; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D002250:Carbon Radioisotopes; D008715:Methionine