title: Human brucellosis in Northern Saudi Arabia.
abstract: OBJECTIVE
  Analysis of the clinical features, laboratory findings, treatment given and complications seen in brucellosis patients at the Northern Area Armed Forces Hospital, Hafr Al-Batin, Kingdom of Saudi Arabia.
  
  
  METHODS
  We retrieved and reviewed the record charts of all patients from January 1995 to December 2001 with a clinical diagnosis of brucellosis whose brucella agglutination titre was 1:160 or greater from the Medical Records Department of Northern Area Armed Forces Hospital, Hafr Al-Batin. We extracted from the files the information on age, gender, occupation, history of raw milk or milk products ingestion, presenting symptoms and physical signs. We also noted the results of routine laboratory tests, treatment given, outcome of treatment and complications.
  
  
  RESULTS
  One hundred and fifty-nine patients (males 101, females 58 with a ratio of 1.7:1) had a diagnostic label of brucellosis and a brucella titre of > or -1:160. Thirty-three (20.8%) were < or -12, 96 (60.3%) were 13-40 years old. Twenty-six (16.4%) were 14-60 years while 4 patients (2.5%) were > or -60 years. Fever (> or -=37.7 degrees C) featured in 126 (79.2%) patients; joint pain in 112 (70.4%); while 77 (48.4%) had bone pain. We recorded the abdominal pain in 18 patients (11.3%) vomiting in 9 (5.7%) and anorexia in 6 (3.8%); splenomegaly in 6 (3.8)%, hepatomegaly and lymphadenopathy in 2 (1.3%) patients. Brucella tube agglutination titres ranged from 1:160 to 1:5120. Thirty-eight (35.8%) patients had anemia (Hb <12 gms/dl); 12 patients (9.8%) had lymphocytosis (lymphocyte count >1 k/L). Ten patients (6.2%) had bacteremia. We used Rifampicin and doxycycline in 87 cases (54.7%), doxycycline and streptomycin in 33 (20.8%), and rifampicin and streptomycin in 20 (12.6%) for 6 weeks or longer (we used combinations including septrin in the remaining patients). We recorded relapse in 18 patients (11.3%). Pneumonia, epididymo-orchitis in 2 cases (1.3%) each, abortion, threatened abortion in one case each, complicated the disease in these patients.
  
  
  CONCLUSIONS
  Brucellosis is endemic in Northern Saudi Arabia as in other parts of the Kingdom. The clinical and laboratory features and response to therapy are also similar.
authors.affiliation: Department of Medicine, Northern Area Armed Forces Hospital, King Khalid Military City, Hafr Al-Batin, Kingdom of Saudi Arabia.
authors.forename: Samira M
authors.initials: SM
authors.lastname: Fallatah
authors.forename: Adekunle J
authors.initials: AJ
authors.lastname: Oduloju
authors.forename: Saad N
authors.initials: SN
authors.lastname: Al-Dusari
authors.forename: Yisa M
authors.initials: YM
authors.lastname: Fakunle
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002002:Brucella / Q000145:classification* / Q000302:isolation & purification; D002006:Brucellosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012529:Saudi Arabia / Q000453:epidemiology; D012720:Severity of Illness Index; D017678:Sex Distribution
chemical_list: D000900:Anti-Bacterial Agents