[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats].
OBJECTIVE
To study the effects of Ligustrazine (Lig) and Radix Astragali (Rad) on activities of myosin adenosine triphosphatase (mATPase) of soleus muscle and atrophy in tail-suspended rat.


METHODS
Weightlessness was simulated by tail suspension in female rats. The activities of mATPase of intrafusal and extrafusal fibres in soleus muscle were detected by method of Ca2(+)-ATPase.


RESULTS
1) Compared with tail-suspended (TS) group, the percentage of type II fibres of SOL in both Ligustrazine (Lig) group and Rad group decreased distinctly. Furthermore, the percentage of type I and type II fibres of SOL in Rad group showed no difference with control (CON) group. 2) The type I CSA of Lig group was markedly larger than that in TS group, and there was no difference as compared with that of CON group. CSA of type I, II and average CSA of Rad group were remarkably larger than those in TS group, and there were no difference as compared with those of CON group. 3) mATPase activities of intrafusal fibres in both Lig group and Rad group were approximate to that of CON group.


CONCLUSIONS
Lig and Rad are both able to effectively prevent muscle atrophy caused by tail suspension, restrain the slow-twitch muscle transform to fast-twitch muscle and control the increase of mATPase activities caused by weightlessness.
Gao
Yun-fang
YF
Fan
Xiao-li
XL
He
Zhi-xian
ZX
Wu
Su-di
SD
Song
Xin-ai
XA
D000818:Animals; D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D018656:Muscle Fibers, Fast-Twitch / Q000187:drug effects; D018657:Muscle Fibers, Slow-Twitch / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects*; D009133:Muscular Atrophy / Q000517:prevention & control*; D009218:Myosins / Q000187:drug effects; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018474:Weightlessness Simulation
D004365:Drugs, Chinese Herbal; D011719:Pyrazines; C027492:Huang Qi; D009218:Myosins; C017953:tetramethylpyrazine