Rhabdomyosarcoma of the cervix in sisters with review of the literature.
OBJECTIVE
Pediatric embryonal heterologous rhabdomyosarcoma of the cervix is a rare tumor.


METHODS
We present an interesting clinico-pathologic situation of two sisters presenting with pediatric embryonal heterologous rhabdomyosarcoma of the cervix.


RESULTS
Pediatric embryonal heterologous rhabdomyosarcomas of the cervix are relatively uncommon. After a Pubmed search from 1952 to present, to our knowledge, this is the only report involving sisters presenting with this disease. Treatment has been extrapolated from collaborative groups such as Intergroup Rhabdomyosarcoma Study (IRS) Group so that optimal management may be achieved.


CONCLUSIONS
We urge continued reporting of these rare tumors to enhance understanding if there may be a genetic component associated with them.
Villella
Jeannine A
JA
Department of Surgery, Division of Gynecologic Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14209, USA.
Bogner
Paul N
PN
Jani-Sait
Sheila N
SN
Block
Anne Marie W
AM
Lele
Shashikant
S
D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D006801:Humans; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000473:pathology; D035781:Siblings; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology