title: Effect of pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes.
abstract: A screening study was conducted to examine the effect of a series of synthesized pyrazoloquinoline derivatives on the growth of Leishmania donovani promastigotes. Sixteen compounds were tested, ten of which showed an inhibitory effect on the growth of promastigotes. Compound 1 demonstrated potent antileishmanial activity, followed by compounds 3 and 7. Some compounds showed less significant activities, while others exhibited little or no activity. Some of these compounds may be potential candidates for future treatment of leishmaniasis.
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Qahtani
authors.forename: Yunus M
authors.initials: YM
authors.lastname: Siddiqui
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Bekhit
authors.forename: Ola A
authors.initials: OA
authors.lastname: El-Sayed
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
authors.forename: Mohammed N
authors.initials: MN
authors.lastname: Al-Ahdalb
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects* / Q000254:growth & development; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D011720:Pyrazoles; D011804:Quinolines