Acute pancreatitis induced by short-term propofol administration.
The incidence of a drug-induced pancreatitis is rare and so far more than 85 different drugs have been reported to have induced pancreatitis. Some case reports consider a relationship between propofol and acute pancreatitis. However, in these cases a number of different drugs were coadministered, thus preventing a clear causal link being established. We report a case of a drug-induced acute pancreatitis that was most likely triggered by a single dosage of propofol. It occurred in a young girl who underwent elective magnetic resonance imaging. She developed pancreatitis within hours after exposure to propofol. Other possible triggers, e.g. gallstones or infection were ruled out. Physicians should consider pancreatitis as a potentially life-threatening adverse event associated with propofol sedation, which is nowadays extensively used.
Gottschling
Sven
S
Department of Pediatric Hematology and Oncology, Universtiy Children's Hospital, Kirrbergestr, Homburg/Saar, Germany. kisgot@uniklinik-saarland.de
Larsen
Reinhard
R
Meyer
Sascha
S
Graf
Norbert
N
Reinhard
Harald
H
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000175:diagnosis; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000601:surgery*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D018237:Germinoma / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010195:Pancreatitis / Q000139:chemically induced*; D015742:Propofol / Q000009:adverse effects*; D016896:Treatment Outcome
D018686:Anesthetics, Intravenous; D015742:Propofol