[Androgen and estrogen receptors in intact, hyperplastic, peritumorous and malignant prostate tissues: a link to proliferation and apoptosis (immunochemical study)].
A total of 134 samples of intact prostate tissue, nodular hyperplasia and prostate cancer were examined. Number of androgen-positive cells was 28.51 +/- 3.50%, Ki-67 expression index - 2.76 +/- 0,45% and Bcl-2--6.25 +/- 1.38% in nodular hyperplastic tissue. In peritumorous epithelial tissue, that parameter dropped to 20.60 +/- 3, 10%, while stromal E+ cells index rose to 19.42 +/- 4, 81. Androgen expression varied 40-90% in tumor epithelium and that of Ki-67--8.26-13.93. Bcl-2 expression was lower in recurrent tumor (4.95 +/- 2.76) as compared with adenocarcinoma microfoci (5.41 +/- 0.71).
Fedosenko
K V
KV
Koval'skiĭ
G B
GB
D000368:Aged; D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000737:chemistry* / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen