[Effect of glutamine and growth hormone on adaptation in short bowel syndrome].
OBJECTIVE
To assess the effects of parenteral glutamine and growth hormone supplementation on gut adaptation for patients with short bowel syndrome.


METHODS
Twenty-six patients [male 15, female 11, aged (39 +/- 23) years] with short bowel syndrome received parenteral nutrition (PN) 3-52 months after surgical resection. The median length of remnant small intestine was 42.5(0-100)cm. All patients received growth hormone (0.10+/- 0.06) mg.kg(-1).d(-1) plus glutamine (0.30 +/- 0.17) mg.kg(-1).d(-1) for two or three weeks.


RESULTS
Among the 26 patients, PN was not required soon after treatment in 34.6% (n=9) of the patients, the frequency and volume of PN decreased from (6.0 +/- 1.0) d to (4.2 +/- 1.0) d, from (13.6 +/- 5.2) L per week to (8.2 +/- 3.3) L per week respectively in 30.8% (n=8) of the patients,while 34.6% (n=9) still required PN after treatment.


CONCLUSIONS
The combined administration of glutamine and growth hormone can promote remnant intestinal adaptation in short bowel patients.
Wu
Guo-hao
GH
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. wugh@zshospital.net
Wu
Zhao-han
ZH
Wu
Zhao-guang
ZG
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005973:Glutamine / Q000627:therapeutic use*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011184:Postoperative Period; D012778:Short Bowel Syndrome / Q000378:metabolism / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult
D005973:Glutamine; D013006:Growth Hormone