[Correlation between fibrinogen polymorphisms and the type of cerebral infarction].
OBJECTIVE
To study the association of beta-fibrinogen(Fg) gene -148 C/T and 448 G/A polymorphisms, plasma Fg concentration, molecular reactivity and the type of cerebral infarction.


METHODS
Gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The plasma Fg concentration and the molecular reactivity were also determined.


RESULTS
The Fg concentration in MCI patients with T -148 allele was higher than that in PCI patients and controls. The MCI patients with A448 allele had higher Fg concentration, FMPV and FMPV/Amax when compared with controls, and had higher FMPV/Amax when compared with PCI patients.


CONCLUSIONS
FgB beta -148 and 448 mutational genotypes have impact on Fg concentrationì and therefore increase the risk of MCI.
Wang
Shu-juan
SJ
Department of Neurology, Kailuan Hospital, Tangshan, Hebei, PR China.
Yuan
Xiao-dong
XD
Gao
Jie
J
Pei
Huan-zhen
HZ
Li
Hong-fen
HF
D000368:Aged; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D005340:Fibrinogen