G proteins in development.
The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and various ion channels. The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development.
Malbon
Craig C
CC
Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, USA. craig@pharm.stonybrook.edu
D000818:Animals; D015509:Developmental Biology; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis / Q000502:physiology*; D021122:Protein Subunits / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*
D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins