ADAM and Eph: how Ephrin-signaling cells become detached.
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.
Mancia
Filippo
F
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Shapiro
Lawrence
L
D051722:ADAM Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000072197:ADAM10 Protein; D000595:Amino Acid Sequence; D053829:Amyloid Precursor Protein Secretases; D018360:Crystallography, X-Ray; D003545:Cysteine / Q000737:chemistry; D036383:Ephrin-A2 / Q000378:metabolism*; D036384:Ephrin-A3 / Q000737:chemistry / Q000378:metabolism*; D036386:Ephrin-A5 / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D016296:Mutagenesis; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D036121:Receptor, EphA3 / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
D036383:Ephrin-A2; D036384:Ephrin-A3; D036386:Ephrin-A5; D008024:Ligands; D008565:Membrane Proteins; D036121:Receptor, EphA3; D053829:Amyloid Precursor Protein Secretases; D051722:ADAM Proteins; D000072197:ADAM10 Protein; C491236:ADAM10 protein, human; D003545:Cysteine