Sperm DNA damage assessment: a test whose time has come.
Multiple techniques have been developed to measure the amount of sperm DNA damage in an effort to identify more objective parameters for evaluation of infertile men. We now have evidence to support that integrity of sperm DNA influences a couple's fertility and helps predict the chances of pregnancy and its successful outcome. The available tests of sperm DNA damage require additional large-scale clinical trials before their integration into routine clinical practice.
Agarwal
Ashok
A
Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. agarwaa@ccf.org
Allamaneni
Shyam S R
SS
D004249:DNA Damage / Q000235:genetics*; D005821:Genetic Techniques; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology*; D008297:Male; D013094:Spermatozoa / Q000473:pathology*