Heart block and empirical therapy after transcatheter closure of perimembranous ventricular septal defect.
Two patients with perimembranous ventricular septal defects (VSDs) and inlet extension have undergone uncomplicated transcatheter device closure using the Amplatzer membranous VSD device. Both patients developed complete heart block 2-4 days from the closure. Both patients responded well to high-dose intravenous therapy with steroids and high-dose oral anti-inflammatory aspirin. Both patients remain in normal sinus rhythm 8 weeks and 10 months, respectively, from the episode.
Yip
William C L
WC
Pediatric Cardiology Service, Gleneagles Hospital, Singapore.
Zimmerman
Frank
F
Hijazi
Ziyad M
ZM
D001241:Aspirin / Q000627:therapeutic use*; D006328:Cardiac Catheterization / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006327:Heart Block / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007223:Infant; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
D005938:Glucocorticoids; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin