title: Hemocompatibility of low-friction boron-carbon-nitrogen containing coatings.
abstract: Mechanical heart valves are exposed to extreme mechanical demands, which require a surface showing not only nonhaemostatic properties, but also wear resistance and low friction. As alternative to different forms of amorphous carbon (a-C), so-called diamond-like carbon (DLC), the suitability of boron carbonitride (BCN) coatings is tested here for hemocompatible coatings. They have similar mechanical properties like a-C surfaces, but superior chemical stability at ferrous substrates or counterparts. BCN films with different nitrogen content were compared with hydrogenated a-C films regarding their mechanical properties, surface energy, adsorption of albumin and fibrinogen, blood platelet adherence, and activation of the contact system of the clotting cascade and kinin system. Similar mechanical properties and biological response have been found in the BCN films with respect to a-C, indicating the potential of these coatings for biomedical applications. The increase in the crystallinity and tribological properties of the BCN samples with a higher incorporation of N was also followed by a lower protein adsorption and low activation of the contact system, but an increased adherence of thrombocytes.
authors.affiliation: Institute of Ion Beam Physics and Materials Research, Forschungszentrum Rossendorf, PF 510119, 01314 Dresden, Germany. manfred@maitz-online.de
authors.forename: M F
authors.initials: MF
authors.lastname: Maitz
authors.forename: R
authors.initials: R
authors.lastname: Gago
authors.forename: B
authors.initials: B
authors.lastname: Abendroth
authors.forename: M
authors.initials: M
authors.lastname: Camero
authors.forename: I
authors.initials: I
authors.lastname: Caretti
authors.forename: U
authors.initials: U
authors.lastname: Kreissig
mesh_terms: D001769:Blood / Q000378:metabolism; D001895:Boron / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism; D004789:Enzyme Activation; D015956:Factor XIIa / Q000378:metabolism; D017276:Friction; D006350:Heart Valve Prosthesis; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D008422:Materials Testing; D009584:Nitrogen / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011474:Prosthesis Design; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D002244:Carbon; D007610:Kallikreins; D015956:Factor XIIa; D009584:Nitrogen; D001895:Boron