title: Visual loss as a first sign of adult-type chronic myeloid leukemia in a child.
abstract: OBJECTIVE
  To report the unusual case of retinal leukemic infiltration in a child with adult-type chronic myelocytic leukemia.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  Complete ophthalmologic examination, including visual acuity measurement and funduscopy. The diagnosis was established by blood cell counts and confirmed by a positive Philadelphia-chromosome translocation (t [9,22]). Treatment consisted of hydroxyurea and stem-cell transplantation.
  
  
  RESULTS
  After therapy, complete regression of the retinal lesion was observed with full recovery of visual acuity.
  
  
  CONCLUSIONS
  This case underlines the importance of interdisciplinary cooperation between ophthalmologists and pediatric oncologists in the diagnosis and treatment of this disease.
authors.affiliation: Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany. guenther.rudolph@med.uni-muenchen.de
authors.forename: Günther
authors.initials: G
authors.lastname: Rudolph
authors.forename: Christos
authors.initials: C
authors.lastname: Haritoglou
authors.forename: Irene
authors.initials: I
authors.lastname: Schmid
authors.forename: Friedericke
authors.initials: F
authors.lastname: Hochhaus
authors.forename: Anselm
authors.initials: A
authors.lastname: Kampik
mesh_terms: D001766:Blindness / Q000175:diagnosis* / Q000628:therapy; D001772:Blood Cell Count; D002648:Child; D005451:Fluorescein Angiography; D018380:Hematopoietic Stem Cell Transplantation; D006529:Hepatomegaly; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000628:therapy; D007964:Leukocytosis / Q000175:diagnosis; D008297:Male; D010677:Philadelphia Chromosome; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D013163:Splenomegaly; D014178:Translocation, Genetic; D014792:Visual Acuity
chemical_list: D006918:Hydroxyurea