Mechanisms of iron-sulfur cluster assembly: the SUF machinery.
Biosynthesis of iron-sulfur clusters is a cellular process which depends on complex protein machineries. Escherichia coli contains two such biosynthetic systems, ISC and SUF. In this review article we specifically make a presentation of the various Suf proteins and discuss the molecular mechanisms by which these proteins work together to assemble Fe and S atoms within a scaffold and to transfer the resulting cluster to target proteins.
Fontecave
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Laboratoire de Chimie et Biochimie des Centres Rédox Biologiques, DRDC-CB, CEA/CNRS/Université Joseph Fourier, CEA-Grenoble, Grenoble Cedex 09, France. mfontecave@cea.fr
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D004926:Escherichia coli / Q000378:metabolism; D007501:Iron / Q000737:chemistry*; D007506:Iron-Sulfur Proteins / Q000096:biosynthesis* / Q000235:genetics*; D013455:Sulfur / Q000737:chemistry*
D007506:Iron-Sulfur Proteins; D013455:Sulfur; D007501:Iron