[Distribution of epidermal growth factor in central nervous system of adult rhesus monkey].
OBJECTIVE
To investigate the distribution of epidermal growth factor (EGF) in the CNS of adult rhesus monkey.


METHODS
Frozen sections were incubated in specific polyclonal anti-EGF antibody by the immunohistochemical SP method.


RESULTS
The EGF immunopositive reaction was observed in the plasma of neurons. The neurons with strong positive immuno-reaction signals were detected in cerebral cortex, cerebellar Purkinje cells, cerebellar nuclei, pyramidal neurons of hippocampus, caudate nucleus, lentiform nucleus, claustrum, nuclei in diencephalons, substantia nigra, cranial nerve nuclei, reticular formation in brain stem, pontine nuclei, red nucleus, superior and inferior olivary nucleus, gracile nucleus, cuneate nucleus, also the ventral horn, lateral horn, dorsal horn and the central gray matter in spinal cord. Furthermore, a few EGF immunopositive glias and fibres were observed in some white matter of central nervous system.


CONCLUSIONS
EGF immunoreactive material was extensively distributed in the CNS of the adult rhesus monkey. The results suggest that EGF may be concerned with various types of neurons and other cells.
Lu
Yong-Chao
YC
Department of Histology, Embryology and Neurobiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Qi
Jian-Guo
JG
Wang
Ting-Hua
TH
Zhou
Xue
X
Feng
Zhong-Tang
ZT
D000818:Animals; D001923:Brain Chemistry; D002490:Central Nervous System / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D007150:Immunohistochemistry; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000378:metabolism; D014018:Tissue Distribution
D004815:Epidermal Growth Factor