Effect of the Pro12Ala polymorphism of the PPARg2 gene on serum adiponectin changes.
The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) gene and adiponectin, a protein secreted from adipose tissue, have been associated with insulin sensitivity. The present study demonstrates that in Finnish servicemen who were on a high-caloric diet for 6 mo only subjects with the Ala 12 allele of PPARgamma2 had a significant increase in adiponectin levels with weight loss induced by heavy exercise. This study demonstrates an interaction of genetic and environmental factors in the regulation of serum adiponectin concentrations.
Mousavinasab
Firoozeh
F
Department of Public Health Science and General Practice, University of Oulu, Finland. fmousavi@student.oulu.fi
Tähtinen
Tuula
T
Jokelainen
Jari
J
Koskela
Pentti
P
Vanhala
Mauno
M
Oikarinen
Jorma
J
Keinänen-Kiukaanniemi
Sirkka
S
Laakso
Markku
M
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015444:Exercise; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic; D015431:Weight Loss / Q000235:genetics
D052242:Adiponectin; D047495:PPAR gamma