Psychopharmacological profile of hydro-alcoholic extract of Euphorbia neriifolia leaves in mice and rats.
The leaf extract of E. neriifolia significantly reduced apomorphine-induced stereotypy in mice at all doses (100, 200, 400 mg/kg body weight) in mice and rats and was devoid of catalepsic effect thereby, suggesting specific dopaminergic receptor modulating activity. The extract (400 mg/kg) potentiated pentobarbitone-induced hypnosis. It showed protection against maximal electro-shock-induced convulsion at 400 mg/kg. E. neriifolia leaf extract had anxiolytic action at 400 mg/kg by increasing the percentage of time spent in open arm in elevated plus-maze. The extract did not reverse scopolamine-induced amnesia on elevated plus-maze. It increased transfer latency at 200 and 400 mg/kg and also in combination with scopolamine. These results indicated anti-anxiety, anti-psychotic and anti-convulsant activity of E. neriifolia leaf extract in mice and rats. Phytochemical study showed the presence of steroidal saponin, reducing sugar, tannins, flavonoids in the crude leaf extract
Bigoniya
Papiya
P
Department of Pharmaceutical Sciences, Dr H S Gour University, Sagar, 470 003, India. p_bigoniya2@hotmail.com
Rana
A C
AC
D000438:Alcohols / Q000378:metabolism; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001835:Body Weight; D002241:Carbohydrates; D002490:Central Nervous System / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology; D015259:Dopamine Agents / Q000378:metabolism; D004597:Electroshock; D028481:Euphorbia / Q000378:metabolism*; D006990:Hypnosis; D018782:Maze Learning; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D012503:Saponins / Q000378:metabolism*; D013997:Time Factors
D000438:Alcohols; D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D002241:Carbohydrates; D002492:Central Nervous System Depressants; D015259:Dopamine Agents; D010936:Plant Extracts; D012503:Saponins; D010424:Pentobarbital; D001058:Apomorphine