Synthesis and biological evaluation of phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides.
The synthesis of carbocyclic 2'-oxa-3'-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.
Chiacchio
Ugo
U
Dipartimento di Scienze Chimiche, Università di Catania, Italy.
Iannazzo
Daniela
D
Piperno
Anna
A
Romeo
Roberto
R
Romeo
Giovanni
G
Rescifina
Antonio
A
Saglimbeni
Monica
M
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D010758:Phosphorus / Q000737:chemistry*; D011684:Purine Nucleosides / Q000737:chemistry*
D000998:Antiviral Agents; D001372:Aza Compounds; D011684:Purine Nucleosides; C468766:oxanine; D010758:Phosphorus