title: Fiber density index correlates with reduced fractional anisotropy in white matter of patients with glioblastoma.
abstract: A quantitative description of white matter fiber attenuation, the fiber density index (FDi) is described. This measure is derived from quantitative analysis of diffusion tensor imaging and reveals an index of the number of fiber paths traversing a region of interest. In this report, FDi is computed in 10 patients with glioblastoma multiforme, in white matter that is peritumoral and contralateral. FDi is shown to correlate significantly with fractional anisotropy.
authors.affiliation: Department of Medical Imaging, University of Toronto, Toronto, Canada.
authors.forename: Tim P L
authors.initials: TP
authors.lastname: Roberts
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Andrea
authors.initials: A
authors.lastname: Kassner
authors.forename: Susumu
authors.initials: S
authors.lastname: Mori
authors.forename: Abhijit
authors.initials: A
authors.lastname: Guha
mesh_terms: D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D009412:Nerve Fibers / Q000473:pathology*