title: [Expression of MMP-2 and E-CD in salivary mucoepidermoid carcinoma and its correlation with infiltration, metastasis and prognosis].
abstract: To study the expressions of matrix metalloproteinase 2 (MMP2) and E-cadherin (E-CD) in salivary mucoepidermoid carcinoma, and their relationship with clinical stages, pathological grading, lymph node metastasis and prognosis.
  
  
  
  Surgical specimens of salivary mucoepidermiod carcinoma and normal salivary gland tissue were collected. MMP-2 and E-CD were stained immunohistochemically with streptavidin peroxidase method.
  
  
  
  The expression of MMP-2 was increased and the expression of E-CD was reduced or negative in salivary mucoepidemoid carcinoma compared with those of the normal salivary gland. Expression of MMP-2 and E-CD was closely correlated with lymph node metastasis of the mucoepidermoid carcinoma. MMP-2 was positively correlated with the prognosis of mucoepidermoid carcinoma, and E-CD was negatively correlated to the prognosis of mucoepidermoid carcinoma.
  
  
  
  The expression of MMP-2 and E-CD is closely correlated with the metastasis and prognosis of salivary mucoepidermoid carcinoma.
authors.affiliation: The Affiliated Stomatological Hospital, College of Medicine, Zhejiang University, Hangzhou 310031, China.
authors.forename: Ji-an
authors.initials: JA
authors.lastname: Hu
authors.forename: Jing-yao
authors.initials: JY
authors.lastname: Xu
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Li
authors.forename: Song-ying
authors.initials: SY
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Ying
mesh_terms: D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D015820:Cadherins; D020778:Matrix Metalloproteinase 2