title: Speech and language findings associated with paraneoplastic cerebellar degeneration.
abstract: Paraneoplastic cerebellar degeneration (PCD) is an autoimmune disease that can be associated with cancer of the breast, lung, and ovary. The clinical presentation of PCD commonly includes ataxia, visual disturbances, and dysarthria. The speech disturbances associated with PCD have not been well characterized, despite general acceptance that dysarthria is often part of the initial presentation. A retrospective study was conducted of the speech, language, and swallowing concerns of patients with PCD evaluated at the Mayo Clinic in Rochester, MN, between 1990 and 2001. Prospective speech and language assessments were then conducted with 5 patients who had PCD. While ataxic dysarthria was the most common speech diagnosis, a spastic component was recognized frequently enough to suggest that the subacute (days to weeks) emergence and progression of an ataxic or mixed ataxic-spastic dysarthria in the setting of a more diffuse cerebellar ataxia should raise suspicions about PCD and justify further investigation of a possible immune-related etiology.
authors.affiliation: Department of Educational Psychology and Special Education, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. teresa.paslawski@usask.ca
authors.forename: Teresa
authors.initials: T
authors.lastname: Paslawski
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Duffy
authors.forename: Steven
authors.initials: S
authors.lastname: Vernino
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology; D001943:Breast Neoplasms / Q000150:complications; D004401:Dysarthria / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications; D020362:Paraneoplastic Cerebellar Degeneration / Q000209:etiology / Q000503:physiopathology*; D010534:Peritoneal Neoplasms / Q000150:complications; D012189:Retrospective Studies
chemical_list: D000951:Antigens, Neoplasm; C505096:PCA-1 antigen, human