[Pathogenesis of primary systemic vasculitides (II): ANCA-negative vasculitides].
The pathogenesis of different types of systemic vasculitis negative for antineutrophil cytoplasm antibodies (ANCA) and involving small or medium-sized vessels is not very well documented. During polyarteritis nodosa (PAN), which is related to hepatitis B virus (HBV) infection, as well as during cryoglobulinemic vasculitides, associated with hepatitis C virus (HCV), and probably during Henoch Schönlein purpura, histological lesions may result from the deposition of immune complexes formed from viral antigens and from antibodies responsible for the activation of the classic complement pathway and for recruitment of polymorphonuclear neutrophils. Two other mechanisms are discussed for other types of ANCA-negative systemic vasculitis: immune complex deposition and sheer stress at arterial bifurcation points. A bacterial superantigen is suspected in Kawasaki disease but remains unproved.
Guilpain
P
P
Université Paris-Descartes, Faculté de médecine, UPRES EA 1833, site Cochin, Paris.
Servettaz
A
A
Tamby
M-C
MC
Chanseaud
Y
Y
Le Guern
V
V
Guillevin
L
L
Mouthon
L
L
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic; D000936:Antigen-Antibody Complex / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D003449:Cryoglobulinemia / Q000276:immunology; D004195:Disease Models, Animal; D016174:Hepacivirus / Q000276:immunology; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus / Q000276:immunology; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology / Q000276:immunology; D051379:Mice; D009080:Mucocutaneous Lymph Node Syndrome / Q000209:etiology / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010488:Polyarteritis Nodosa / Q000209:etiology / Q000276:immunology; D012212:Rheology; D014657:Vasculitis / Q000209:etiology* / Q000276:immunology* / Q000503:physiopathology
D019268:Antibodies, Antineutrophil Cytoplasmic; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral