title: Investigation of erythrocyte shape, plasma membrane fluidity and conformation of haemoglobin haemoporphyrin under the influence of long-term space flight.
abstract: The investigation of long-term space flight (SF) effect on the blood cells function is of great importance for modern space biology and medicine. We established that the number of discocytes decreased in the period of early rehabilitation after long-term SF. After SF plasma membrane fluidity and phospholipid content decreased and cholesterol content increased. After SF the amount of haemoglobin decreased and the parameters characterizing haemoglobin haemoporyphyrin (HH) conformation changed. We suppose that erythrocyte shape, membrane fluidity and HH conformation are among factors affecting oxygen transfer during and after space flight.
authors.affiliation: State Scientific Center-Institute of Biomedical Problems, Moscow, Russia. maxim@biophys.msu.ru
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoriev
authors.forename: G V
authors.initials: GV
authors.lastname: Maksimov
authors.forename: B V
authors.initials: BV
authors.lastname: Morukov
authors.forename: S M
authors.initials: SM
authors.lastname: Ivanova
authors.forename: Yu V
authors.initials: YV
authors.lastname: Yarlikova
authors.forename: O G
authors.initials: OG
authors.lastname: Luneva
authors.forename: N A
authors.initials: NA
authors.lastname: Ulyanova
authors.forename: E Yu
authors.initials: EY
authors.lastname: Parshina
authors.forename: A B
authors.initials: AB
authors.lastname: Rubin
mesh_terms: D002784:Cholesterol / Q000097:blood; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology*; D006454:Hemoglobins / Q000502:physiology; D006801:Humans; D008560:Membrane Fluidity; D010743:Phospholipids / Q000097:blood; D011166:Porphyrins / Q000097:blood / Q000502:physiology; D013026:Space Flight; D014893:Weightlessness
chemical_list: D006454:Hemoglobins; D010743:Phospholipids; D011166:Porphyrins; D002784:Cholesterol