title: [Correlation between fibrinogen polymorphisms and the type of cerebral infarction].
abstract: OBJECTIVE
  To study the association of beta-fibrinogen(Fg) gene -148 C/T and 448 G/A polymorphisms, plasma Fg concentration, molecular reactivity and the type of cerebral infarction.
  
  
  METHODS
  Gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The plasma Fg concentration and the molecular reactivity were also determined.
  
  
  RESULTS
  The Fg concentration in MCI patients with T -148 allele was higher than that in PCI patients and controls. The MCI patients with A448 allele had higher Fg concentration, FMPV and FMPV/Amax when compared with controls, and had higher FMPV/Amax when compared with PCI patients.
  
  
  CONCLUSIONS
  FgB beta -148 and 448 mutational genotypes have impact on Fg concentrationì and therefore increase the risk of MCI.
authors.affiliation: Department of Neurology, Kailuan Hospital, Tangshan, Hebei, PR China.
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Wang
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Yuan
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Huan-zhen
authors.initials: HZ
authors.lastname: Pei
authors.forename: Hong-fen
authors.initials: HF
authors.lastname: Li
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005340:Fibrinogen