Simultaneous deep vein thrombosis and transverse myelitis with negative serology as a first sign of antiphospholipid syndrome: a case report and review of the literature.
Transverse myelitis is a rare manifestation of antiphospholipid syndrome, usually secondary to systemic lupus erythematosus (Rheum Dis Clin North Am 20:129-158, 1994). Only about 110 reports of this complication have been reported (Lupus 10:851-856, 2001). A connection has been demonstrated between positive serology for antiphospholipid and transverse myelitis (Lupus 8:109-115, 1999). Herein, we report of a young patient admitted with deep vein thrombosis and neurological manifestations of transverse myelitis with negative serology for systemic lupus erythematosus and antiphospholipid, who developed positive anticardiolipin antibody during pulse therapy with cyclophosphamide and methylprednisolone.
Carter
Dan
D
Internal Medicine, Sheba Medical Center, Tel Hashomer, 52621 Ramat Gan, Israel. carterd@zahav.net.il
Olchovsky
David
D
Yonath
Hagit
H
Langevitz
Pnina
P
Ezra
David
D
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009188:Myelitis, Transverse / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D020551:Pulse Therapy, Drug; D012698:Serologic Tests; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014859:Warfarin / Q000627:therapeutic use
D017153:Antibodies, Anticardiolipin; D007166:Immunosuppressive Agents; D014859:Warfarin; D003520:Cyclophosphamide; D008775:Methylprednisolone