Electrical communication between NAD-dependent enzyme and metal electrode using ferrocene-labeled NAD derivatives.
The target N6-ferrocene substituted NAD derivatives (ferrocene-labeled NAD, Fc-NAD) were synthesized as an electron-relay NAD cofactor. The synthesized NAD derivatives possessed some biological activities as substrates in the alcohol dehydrogenase systems. The oxidation current depended on both addition of ethanol and spacer length of Fc-NAD.
Kijima
Tatsuro
T
Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan. kijima@yz.yamagata-u.ac.jp
Suzuki
Tatsunori
T
Izumi
Taeko
T