Synthesis and transformation of [difluoro(phenylseleno)methyl]- trimethylsilane.
[reaction: see text] A novel and efficient strategy was developed to synthesize [difluoro(phenylseleno)methyl]trimethylsilane (PhSeCF(2)TMS, 2), which was further utilized as a nucleophilic difluoromethylating reagent to incorporate the difluoro(phenylseleno)methyl (PhSeCF(2)) group into carbonyl compounds in good yields. The resulting PhSeCF(2)-containing alcohols 3 could be conveniently converted into corresponding difluoromethyl alcohols 4 by a radical deselenylation.
Qin
Ying-Ying
YY
College of Chemistry and Chemical Engineering, Donghua University, Shanghai, China.
Qiu
Xiao-Long
XL
Yang
Yan-Yan
YY
Meng
Wei-Dong
WD
Qing
Feng-Ling
FL