title: Conjugate pneumococcal vaccine in HIV-infected Ugandans and the effect of past receipt of polysaccharide vaccine.
abstract: We investigated the immunogenicity of a 7-valent conjugate pneumococcal vaccine (CPV) in human immunodeficiency virus-infected Ugandan adults and measured the effect of past pneumococcal polysaccharide vaccine (PPV) receipt given as part of a controlled trial. Two doses of CPV, 4 weeks apart, were given to 54 past PPV recipients and 55 past placebo recipients (84% female; median CD4 cell count, 251 cells/ microL [range, 1-936 cells/ microL]). Postvaccination anticapsular immunoglobulin G (IgG) concentrations were directly correlated with CD4 cell count (P < .01 for all serotypes). There were significant increases in anticapsular IgG concentrations for all serotypes after the first dose (P < .01) and for all serotypes except 14 and 9V after the second dose. Past receipt of PPV did not affect vaccine response.
authors.affiliation: Medical Research Council Programme on AIDS, Entebbe, Uganda.
authors.forename: George
authors.initials: G
authors.lastname: Miiro
authors.forename: Helena
authors.initials: H
authors.lastname: Kayhty
authors.forename: Christine
authors.initials: C
authors.lastname: Watera
authors.forename: Helen
authors.initials: H
authors.lastname: Tolmie
authors.forename: James A G
authors.initials: JA
authors.lastname: Whitworth
authors.forename: Charles F
authors.initials: CF
authors.lastname: Gilks
authors.forename: Neil
authors.initials: N
authors.lastname: French
mesh_terms: D000328:Adult; D016667:Bacterial Capsules / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology; D016896:Treatment Outcome; D014454:Uganda; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate