Fibrolamellar hepatocellular carcinoma arising in a background of focal nodular hyperplasia: a report of 2 cases.
BACKGROUND
Fibrolamellar carcinoma, a rare variant of hepatocellular carcinoma, and focal nodular hyperplasia, a benign lesion, are rare hepatic lesions that are known to occur in young women with noncirrhotic livers. Some have suggested that fibrolamellar carcinoma might be the malignant counterpart of focal nodular hyperplasia. The coexistence of the 2 lesions is very rare.


METHODS
Two cases of fibrolamellar hepatocellular carcinoma arising in a background of focal nodular hyperplasia followed long-term oral contraception, and 1 of the 2 occurred during pregnancy.


CONCLUSIONS
Distinguishing fibrolamellar carcinoma from focal nodular hyperplasia has important implications for treatment and prognosis. One should be aware of such conditions, especially in patients with a long history of oral contraception.
Imkie
Marwa
M
Departments of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA.
Myers
Stephen A
SA
Li
Yu
Y
Fan
Fang
F
Bennett
Timothy L
TL
Forster
Jameson
J
Tawfik
Ossama
O
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
D003276:Contraceptives, Oral