title: Critically short telomeres are associated with sperm DNA fragmentation.
abstract: The influence of critical telomeric attrition, a well-known trigger of apoptosis and cell arrest, on sperm DNA fragmentation was studied in late-generation knockout mice for Terc, the RNA component of telomerase, as a model of choice. Terc knockout mice had a sixfold mean increase in the percentage of sperm cells with fragmented DNA.
authors.affiliation: Unidad de Investigación, Complejo Hospitalario Universitario Juan Canalejo, Instituto de Ciencias de la Salud, Universidad de La Coruña, A Coruña, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Rodríguez
authors.forename: Vicente
authors.initials: V
authors.lastname: Goyanes
authors.forename: Enrique
authors.initials: E
authors.lastname: Segrelles
authors.forename: María
authors.initials: M
authors.lastname: Blasco
authors.forename: Jaime
authors.initials: J
authors.lastname: Gosálvez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Fernández
mesh_terms: D000818:Animals; D053938:DNA Fragmentation / Q000235:genetics*; D005821:Genetic Techniques; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology*; D016615:Telomere / Q000235:genetics* / Q000473:pathology