title: Serum evaluation of the balance between soluble interleukin-2 and interleukin-4 receptors.
abstract: To elucidate the usefulness of the simultaneous analysis of the multiple kinds of soluble cytokine receptors, we determined both the soluble interleukin 2 receptor (sIL-2R, Th1-type cytokine receptor) and the soluble interleukin 4 receptor (sIL-4R, Th2-type cytokine receptor) levels in the sera of healthy subjects as reference values and preliminarily applied to evaluate the patients with diarrhea positive (D+) hemolytic uremic syndrome (HUS) as the diagnostic parameter of the severity. Both sIL-2R and sIL-4R levels in the sera of healthy children were significantly higher than those of healthy adults (p<0.01). The serum sIL-2R level of the patients with severe HUS (n=4) was higher than that of the patients with mild/moderate HUS (n=6) at the initial stage (p<0.01) or healthy children (n=51, p<0.01). Whereas, the serum sIL-4R level of both the severe and mild/moderate groups was lower than that of the healthy control children, although there was no significant difference among the three groups. Namely, the soluble receptor balance (sIL-2R/sIL-4R) in the patients with severe HUS may shift. We considered that the evaluation of the balance between soluble cytokine receptors might be informative for the evaluation of the immune states, as well as the conventional cytokine balance (Th1/Th2).
authors.affiliation: Department of Pediatrics, Toyohashi Municipal Hospital, 50 Hakken-nishi, Aotake-cho, Toyohashi, 441-8570, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujita
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Gotoh
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yada
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tsunesaburo
authors.initials: T
authors.lastname: Ando
authors.forename: Hajime
authors.initials: H
authors.lastname: Togari
authors.forename: Mikio
authors.initials: M
authors.lastname: Nishida
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000097:blood / Q000209:etiology / Q000276:immunology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D019948:Receptors, Interleukin-4 / Q000097:blood*; D012995:Solubility
chemical_list: D015375:Receptors, Interleukin-2; D019948:Receptors, Interleukin-4