title: Selective regulation of cellular processes via protein cascades acting as band-pass filters for time-limited oscillations.
abstract: We show by mathematical modelling that a two-level protein cascade can act as a band-pass filter for time-limited oscillations. The band-pass filters are then combined into a network of three-level signalling cascades that by filtering the frequency of time-limited oscillations selectively switches cellular processes on and off. The physiological relevance for the selective regulation of cellular processes is demonstrated for the case of regulation by time-limited calcium oscillations.
authors.affiliation: Department of Physics, Faculty of Education, University of Maribor, Slovenia. marko.marhl@uni-mb.si
authors.forename: Marko
authors.initials: M
authors.lastname: Marhl
authors.forename: Matjaz
authors.initials: M
authors.lastname: Perc
authors.forename: Stefan
authors.initials: S
authors.lastname: Schuster
mesh_terms: D020013:Calcium Signaling / Q000502:physiology*; D003198:Computer Simulation; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011506:Proteins