title: Variant Creutzfeldt-Jakob disease: implications for the health care system.
abstract: The recognition of the first cases of variant Creutzfeldt-Jakob Disease in the United Kingdom (UK) in 1996 and the realisation that this new disease represented the human form of the cattle disease BSE has prompted a considerable investment in research, particularly in the UK, Europe and the United States (US). Much has been learnt about this disease but much is still unknown. Infectivity is not destroyed by conventional sterilisation and disinfection treatment methods. This, combined with the widespread distribution throughout the lymphoid system as well as the central nervous system, raises the spectre of transmission through both surgical and ophthalmological procedures. Reports in 2004 of two likely transfusion-transmitted cases of vCJD suggest the probability of infection through blood transfusion and tissue transplantation. The risk of hospital-based and community-based transmission has not been quantified. To complicate matters even further, there is no suitable ante-mortem screening test or effective treatment for this fatal disease. The incubation period prior to onset of clinical disease is many years and there is good evidence for the existence of subclinical infection and infectivity during this stage. The extent of under-diagnosis and misdiagnosis is probably significant, adding to the risk of human-to-human transmission.
authors.affiliation: Australian Biosecurity CRC for Emerging Infectious Disease, School of Biomedical Sciences, Curtin University, Western Australia. r.dunstan@curtin.edu.au
authors.forename: R A
authors.initials: RA
authors.lastname: Dunstan
authors.forename: M P
authors.initials: MP
authors.lastname: Alpers
mesh_terms: D000818:Animals; D001315:Australia / Q000453:epidemiology; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D003695:Delivery of Health Care; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D065227:Transfusion Reaction; D006113:United Kingdom / Q000453:epidemiology; D014481:United States