title: The more closed the bypass system the better: a pilot study on the effects of reduction of cardiotomy suction and passive venting on hemostatic activation during on-pump coronary artery bypass grafting.
abstract: Cardiac surgery with cardiopulmonary bypass (CPB) leads to a powerful activation of the hemostatic system. We assessed to what extent this activation can be attenuated by comparing three different perfusion regimens for on-pump coronary artery bypass grafting (CABG): 1) use of a closed CPB system with aspiration of blood from the operation field via the cardiotomy suction line and active venting of the heart via a roller pump; 2) use of a closed CPB system avoiding aspiration of blood from the operation field via the cardiotomy suction line, but with active venting of the heart; and 3) use of a closed system, avoidance of aspiration of blood from the operation field via the cardiotomy suction line and with passive venting of the heart into the collapsible venous reservoir. Our data show that avoidance of aspiration of blood via the cardiotomy suction line significantly reduces hemostatic activation during on-pump CABG. However, further attenuation of hemostatic activation can be achieved by further closing the system and minimizing the blood/air interface by passive venting of the heart.
authors.affiliation: Department of Anesthesia, Deutsches Herzzentrum Berlin, Berlin, Germany. koster@dhzb.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Koster
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Böttcher
authors.forename: Frank
authors.initials: F
authors.lastname: Merkel
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Hermann
authors.initials: H
authors.lastname: Kuppe
mesh_terms: D001777:Blood Coagulation; D016063:Blood Loss, Surgical; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006464:Hemoperfusion / Q000009:adverse effects / Q000379:methods; D006487:Hemostasis; D006801:Humans; D008722:Methods; D010865:Pilot Projects; D013396:Suction