Glycosaminoglycans of the vertebral body growth plate in patients with idiopathic scoliosis.
The concentrations of keratan sulfates and unmodified keratan sulfates increased in the vertebral body growth plate in patients with idiopathic scoliosis. Sulfation and acetylation of total glycosaminoglycans decreased by 50 and 30%, respectively. These changes reflect the decrease in biological activity of molecules that modulate function of the growth plate.
Rusova
T V
TV
Novosibirsk Institute of Traumatology and Orthopedics, Russian Ministry of Health, Russia. trusova@niito.ru
Rykova
V I
VI
Korel
A V
AV
Zaidman
A M
AM
Tkachev
D S
DS
D000107:Acetylation; D000293:Adolescent; D016022:Case-Control Studies; D006025:Glycosaminoglycans / Q000032:analysis* / Q000737:chemistry; D006132:Growth Plate / Q000737:chemistry* / Q000503:physiopathology; D006801:Humans; D007632:Keratan Sulfate / Q000032:analysis / Q000737:chemistry; D012600:Scoliosis / Q000378:metabolism* / Q000503:physiopathology*; D013131:Spine / Q000737:chemistry* / Q000503:physiopathology; D013904:Thoracic Vertebrae / Q000737:chemistry / Q000503:physiopathology
D006025:Glycosaminoglycans; D007632:Keratan Sulfate