title: Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest.
abstract: Orthostatic intolerance is common after space flight and head-down tilt (HDT) bed rest. We hypothesized that HDT-induced impairments of arterial blood pressure (AP) control would be more marked during exercise and that recovery of baroreflex function after very long-term HDT would be delayed. Six subjects were studied before (BDC) during (day 60, D60; D113) and after (recovery day 0, R0; R3; R15) 120 days of HDT. Supine resting subjects were exposed to repeated 1 min passive tilts to upright at 3-min interval. During 50 W steady-state exercise corresponding tilt had a 2-min duration at 4-min interval. The amplitudes of the tilt-induced transient beat-by-beat deviations in AP and rate (HR) were determined during the gravity transients. At rest these deviations did not change over time, but during exercise the total peak-to-nadir range of deviations in systolic AP (SAP) at up-tilt and down-tilt increased to 168+/-16% (mean+/-SEM) of BDC at D113 with no clear recovery upto and including R15. Counter-regulatory HR responses were not increased proportionally and especially not tachycardic responses to up-tilt, resulting in a reduction of baroreflex sensitivity (deltaRR-interval/deltaSAP) by 55+/-9% of BDC at D113 with no recovery upto and including R15. We conclude that prolonged bed rest cause long-lasting impairments in AP control and baroreflex function in exercising humans.
authors.affiliation: Section of Environmental Physiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden. Dag.Linnarsson@fyfa.ki.se
authors.forename: D
authors.initials: D
authors.lastname: Linnarsson
authors.forename: J
authors.initials: J
authors.lastname: Spaak
authors.forename: P
authors.initials: P
authors.lastname: Sundblad
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D017704:Baroreflex; D001510:Bed Rest; D015444:Exercise; D018475:Head-Down Tilt; D006339:Heart Rate; D006801:Humans; D008297:Male; D011187:Posture; D013995:Time; D013997:Time Factors