title: Three new pimaren diterpenoids from marine mangrove plant, Bruguiera gymnorrhiza.
abstract: Three new pimaren diterpenoids, ent-8(14)-pimarene-15R, 16-diol (1), ent-8(14)-pimarene-1alpha,15R,16-triol (2), and (5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol (3), along with three known diterpenoids (4-6) have been isolated from the stem of mangrove plant Bruguiera gymnorrhiza. The structures of compounds 1-3 were determined by extensive spectroscopic (2D NMR, MS, IR, and CD) analysis, and 3 and 5 showed moderate cytotoxic activities against L-929 and K562, respectively.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
authors.forename: I
authors.initials: I
authors.lastname: Sattler
authors.forename: H M
authors.initials: HM
authors.lastname: Dahse
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Fu
authors.forename: S
authors.initials: S
authors.lastname: Grabley
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018547:Plant Stems / Q000737:chemistry; D043982:Rhizophoraceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: C505642:(5R, 9S, 10R, 13S, 15S)-ent-8(14)-pimarene-1-oxo-15R,16-diol; D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007202:Indicators and Reagents; C505643:ent-8(14)-pimarene-15R, 16-diol; C505641:ent-8(14)-pimarene-1alpha,15R,16-triol