[Lack of direct cytotoxic effect of intracellular nanotubes].
Nanotubes have a great therapeutic potential due to their astounding physico-chemical features, the possibility to be funtionalised for ad hoc uses, and the specific interaction of nanotubes as such with life molecules (DNA and proteins). These features recommend a thorough toxicological study before widespread pharmaceutic use. We provide evidence that culture cells with phagocytic potential internalise multi wall nanotubes (10-50 nm average size). This is not accompanied by cytotoxicity in terms of induction of &apoptosis or necrosis at the doses used (up to 125 microg/mI).
Ghibelli
L
L
Dipartimento di Biologia, Università di Roma Tor Vergata.
De Nicola
M
M
Somma
G
G
Cerella
C
C
D'Alessio
M
M
Romeo
E
E
Magrini
A
A
Bergamaschi
A
A
D017209:Apoptosis; D002478:Cells, Cultured; D003470:Culture Media; D006801:Humans; D037742:Nanotubes, Carbon / Q000633:toxicity*; D009336:Necrosis; D010586:Phagocytes; D013997:Time Factors; D018675:Toxicity Tests
D003470:Culture Media; D037742:Nanotubes, Carbon