[On the mechanism of the nonspecific cell response to the action of damaging agents and the nature of hormesis].
A conception of the molecular mechanism of the universal nonspecific cell response (NCR) to the action of all damaging factors of physical and chemical nature is described. The mechanism is shown to be closely related to the general principles of the structural-functional organization of cells and to the properties of biological macromolecules. Among them are the phenomenon of nonspecific regulation of the enzyme activity by low-molecular substances and the compartmentation of the latter within the cell, which is provided by the system of intracellular membranes. Special attention is paid to the role of disturbance of the barrier function, of membranes in the development of the nonspecific cell response, and the activation of repair of cell injuries. Based on the theory of nonspecific cell response, the stimulating effect of weak action of agents that damage the cells at high doses (the phenomenon named as hormesis) is explained.
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D000818:Animals; D006224:Cricetinae; D005347:Fibroblasts / Q000502:physiology; D006706:Homeostasis / Q000502:physiology* / Q000528:radiation effects; D051379:Mice; D009865:Oocytes / Q000502:physiology / Q000528:radiation effects