title: Comparative simulations of aquaporin family: AQP1, AQPZ, AQP0 and GlpF.
abstract: Molecular dynamics simulations were performed for four members of the aquaporin family (AQP1, AQPZ, AQP0, and GlpF) in the explicit membrane environment. The single-channel water permeability, pf, was evaluated to be GlpF approximately AQPZ > AQP1 >> AQP0, while their relative pore sizes were GlpF >> AQP1 > AQPZ >> AQP0. This relation between pf and pore size indicates that water permeability was determined not only by the channel radius, but also another competing factor. Analysis of water dynamics revealed that this factor was the single-file nature of water transport.
authors.affiliation: International Graduate School of Arts and Sciences, Yokohama City University, Tsurumi-ku, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hashido
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ikeguchi
authors.forename: Akinori
authors.initials: A
authors.lastname: Kidera
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D051398:Aquaporin 1 / Q000737:chemistry*; D020346:Aquaporins / Q000737:chemistry*; D003198:Computer Simulation; D006801:Humans; D008969:Molecular Sequence Data; D010539:Permeability; D014867:Water / Q000737:chemistry
chemical_list: D020346:Aquaporins; D014867:Water; D051398:Aquaporin 1