title: Reduction in central line-associated bloodstream infections among patients in intensive care units--Pennsylvania, April 2001-March 2005.
abstract: Each year, an estimated 250,000 cases of central line-associated (i.e., central venous catheter-associated) bloodstream infections (BSIs) occur in hospitals in the United States, with an estimated attributable mortality of 12%-25% for each infection. The marginal cost to the health-care system is approximately 25,000 dollars per episode. In 2001, CDC was invited by the Pittsburgh Regional Healthcare Initiative (PRHI) to provide technical assistance for a hospital-based intervention to prevent central line-associated BSIs among intensive care unit (ICU) patients in southwestern Pennsylvania. During a 4-year period, BSI rates among ICU patients declined 68%, from 4.31 to 1.36 per 1,000 central line days. The results suggest that a coordinated, multi-institutional infection-control initiative might be an effective approach to reducing health-care-associated infections.
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000592:standards*; D006801:Humans; D017053:Infection Control; D007362:Intensive Care Units / Q000706:statistics & numerical data; D010414:Pennsylvania / Q000453:epidemiology; D018805:Sepsis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*