Serum uric acid levels and the risk of Parkinson disease.
In a prospective population-based cohort study among 4,695 participants aged 55 years and older, with repeated in-person examination and on average 9.4 years of follow-up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51-0.98]), with evidence for a dose-effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid.
de Lau
Lonneke M L
LM
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Koudstaal
Peter J
PJ
Hofman
Albert
A
Breteler
Monique M B
MM
D000368:Aged; D000369:Aged, 80 and over; D018672:Community Health Planning; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000097:blood* / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid