Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand(hi) population.
In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo) (CD62Llo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset.
Kipnis
Andre
A
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Irwin
Scott
S
Izzo
Angelo A
AA
Basaraba
Randall J
RJ
Orme
Ian M
IM
D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000096:biosynthesis*; D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics; D018960:Hyaluronan Receptors / Q000276:immunology / Q000378:metabolism*; D007156:Immunologic Memory / Q000276:immunology*; D016130:Immunophenotyping; D007538:Isoniazid / Q000627:therapeutic use; D019041:L-Selectin / Q000276:immunology / Q000378:metabolism*; D008168:Lung / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013997:Time Factors
D020410:Activated-Leukocyte Cell Adhesion Molecule; D000995:Antitubercular Agents; D001500:BCG Vaccine; C476399:Cd44 protein, mouse; D018398:Homeodomain Proteins; D018960:Hyaluronan Receptors; D019041:L-Selectin; C064658:RAG-1 protein; D007538:Isoniazid