Resolution of EBV(+) CNS lymphoma with appearance of CSF EBV-specific T cells.
Current knowledge of Epstein-Barr virus (EBV)-specific T-cell responses in the cerebrospinal fluid (CSF) of patients with EBV-related lymphoproliferative disease (EBV-LPD) in the central nervous system (CNS) is very limited. Here, we present two recipients of hematopoietic stem cell transplants with EBV-LPD in the CNS. EBV-specific CD8(+) T lymphocytes were detected in CSF and peripheral blood using major histocompatibility complex (MHC) class I multimers loaded with EBV-derived peptides. The appearance of EBV-specific CD8(+) T cells in CSF and blood correlated with neurological improvement and disappearance of EBV-LPD. These observations suggest a role for EBV-specific CD8(+) T cells in the control of EBV-LPD in the CNS.
de Beukelaar
Janet W
JW
Department of Medical Oncology, Erasmus MC, Rotterdam, The Netherlands.
van Arkel
Cornelis
C
van den Bent
Martin J
MJ
van't Veer
Mars B
MB
van Doornum
Gerard J
GJ
Cornelissen
Jan J
JJ
Sillevis Smitt
Peter A
PA
Gratama
Jan W
JW
D000368:Aged; D016827:CD8 Antigens / Q000378:metabolism; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid / Q000601:surgery / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000821:virology; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008223:Lymphoma / Q000134:cerebrospinal fluid / Q000601:surgery / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000821:virology*; D013997:Time Factors; D015534:Trans-Activators / Q000378:metabolism
D016827:CD8 Antigens; C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators