title: Efficacy of oral telithromycin in community-acquired pneumonia caused by resistant Streptococcus pneumoniae.
abstract: The efficacy of oral telithromycin 800mg once daily for 7 days was evaluated in a multicentre, multinational study in patients with community-acquired pneumonia caused by Streptococcus pneumoniae resistant to penicillin and/or erythromycin. Per-protocol clinical and bacteriological outcomes were assessed 10-17 days post-therapy. Of the 129 patients with S. pneumoniae infection, 16 were infected with strains resistant to penicillin and/or erythromycin. Fifteen of these 16 patients (93.8%) were assessed as clinically and bacteriologically cured at the post-therapy visit.
authors.affiliation: Drs Joynt, Venter and Associates, Medpark Center, P.O. Box 154, Witbank, 1035 South Africa. jp-ass@mweb.co.za
authors.forename: Dirkie
authors.initials: D
authors.lastname: van Rensburg
authors.forename: Charles
authors.initials: C
authors.lastname: Fogarty
authors.forename: María Cristina
authors.initials: MC
authors.lastname: De Salvo
authors.forename: Manickam
authors.initials: M
authors.lastname: Rangaraju
authors.forename: Roomi
authors.initials: R
authors.lastname: Nusrat
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D048628:Ketolides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D010406:Penicillins; D004917:Erythromycin; C106791:telithromycin