[Experience in treating advanced prostate cancer with bladder outlet obstruction].
OBJECTIVE
The incidence and discovery rate of prostate cancer is increased in recent years; with advanced age and multiple organs dysfunction, the advanced prostate cancer patients have poor quality of life. This study was to explore suitable treatment for these patients.


METHODS
A total of 80 advanced prostate cancer patients with bladder outlet obstruction were treated by transurethral electrovaporization of the prostate (TVP), plus castration and antiandrogen therapy. Preoperative individualized preparation was performed for each patient. International prostatic symptom score (IPSS), maximum flow rate of urine (Q(max)), prostatic-special antigen (PSA), and ultrasonography were measured before and 3 months after operation.


RESULTS
TVP were successful in all cases. Postoperative IPSS was significantly lower than preoperative IPSS in patients with or without urine retention (13+/-3 vs. 31+/-2, 11+/-3 vs. 31+/-2, P<0.01); postoperative Q(max) was significantly higher than preoperative Q(max) in patients with or without urine retention [(19.0+/-3.3) ml/s vs. 0, (19.4+/-2.7) ml/s vs. (8.9+/-3.4) ml/s, P<0.01]. Postoperative PSA was significantly lower than preoperative PSA [(80.4+/-133.4) mg/L vs. (0.1+/-0.4) mg/L, P<0.05]. The volume of prostate was obviously reduced.


CONCLUSIONS
TVP plus castration and endocrine therapy is a safe and effective treatment for advanced prostate cancer patients with bladder outlet obstruction.
Sheng
Xu-Jun
XJ
Department of Urology, Xinhua Hospital, Shanghai Second Medical University, Shanghai, P.R. China. shengxujunjj@hotmail.com
Zhu
Ying-Jian
YJ
Ye
Min
M
Chen
Jian-Hua
JH
Zhang
Liang
L
Kong
Liang
L
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000097:blood; D005485:Flutamide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D020728:Transurethral Resection of Prostate; D001748:Urinary Bladder Neck Obstruction / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000601:surgery*
D000726:Androgen Antagonists; D000951:Antigens, Neoplasm; C019454:pancreas-specific antigen; D005485:Flutamide