title: Determination of salbutamol in pharmaceuticals by capillary electrophoresis.
abstract: A capillary electrophoresis (CE) method for the separation and determination of salbutamol (SAL) in commercial pharmaceuticals was developed. Several parameters affecting the separations were studied including type and concentration of the carrier ion, counter ion, and the pH of the buffer. A hydrodynamically closed CE separation mode employing a 300 mum I.D. capillary, dynamically coated by polymeric buffer additive, provided good performance parameters (precision, accuracy, sensitivity). The obtained results suggest that the proposed method is suitable for routine assay of SAL in pharmaceutical preparations and can be used as an alternative to the conventional open CE mode for this application.
authors.affiliation: Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. mikus@fpharm.uniba.sk
authors.forename: Peter
authors.initials: P
authors.lastname: Mikus
authors.forename: Iva
authors.initials: I
authors.lastname: Valásková
authors.forename: Emil
authors.initials: E
authors.lastname: Havránek
mesh_terms: D000318:Adrenergic beta-Agonists / Q000032:analysis*; D000420:Albuterol / Q000032:analysis*; D004573:Electrolytes; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D013607:Tablets
chemical_list: D000318:Adrenergic beta-Agonists; D004573:Electrolytes; D004364:Pharmaceutical Preparations; D013607:Tablets; D000420:Albuterol