title: N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase.
abstract: Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors.
authors.affiliation: Laboratoire de Synthèse et de Physico-Chimie de Molécules d'intérêt Biologique, Groupe de Chimie Organique Biologique, UMR 5068, Université Paul Sabatier, Bât IIR1, 118 route de Narbonne, 31062 Toulouse Cedex 4, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Gavalda
authors.forename: Rémi
authors.initials: R
authors.lastname: Braga
authors.forename: Chantal
authors.initials: C
authors.lastname: Dax
authors.forename: Alain
authors.initials: A
authors.lastname: Vigroux
authors.forename: Casimir
authors.initials: C
authors.lastname: Blonski
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors*; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D007700:Kinetics; D008322:Mammals; D063065:Organophosphonates / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D063065:Organophosphonates; D005634:Fructose-Bisphosphate Aldolase