A new catalytic conjugate addition/aldol strategy that avoids preformed metalated nucleophiles.
A new conjugate addition/aldol strategy has been developed. Unlike conventional procedures that require metalation of the nucleophilic species, the procedure allows the direct coupling of aryl iodides, aldehydes, and acrylates in a nickel-catalyzed, organozinc-promoted process.
Subburaj
Kandasamy
K
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Montgomery
John
J