title: Prognostic value of umbilical-middle cerebral artery pulsatility index ratio in fetuses with growth restriction.
abstract: OBJECTIVE
  To study the utility of Doppler velocimetry and computerized cardiotocography in the management of intrauterine growth restriction and prediction of neonatal outcome.
  
  
  METHODS
  Seventy-two pregnant women with fetuses showing growth restriction and delivered within 48 h of their last Doppler velocimetry evaluation. The last computerized cardiotocographic trace from these fetuses was used for statistical analysis, and the last trace from the healthy fetuses of 93 consecutive women undergoing cesarean section was used as control. Umbilical artery pulsatility index (UA PI), middle cerebral artery pulsatility index (MCA PI), UA PI/MCA PI ratio, and uterine artery resistance index (Ut RI) were assessed.
  
  
  RESULTS
  Among women with growth-restricted fetuses, all parameters were significantly higher in those who had hypertension; and in those who had diabetes, only the UA PI/MCA ratio was significantly higher. Umbilical artery PI values and the UA PI/MCA ratio were higher in those who had a nonreassuring result to computerized nonstress test immediately before delivery. A multiple logistic analysis showed that the UA PI/MCA ratio was the only Doppler velocimetry parameter predicting cardiotocographic nonreactivity; furthermore, the predictivity of extended newborn hospitalization (longer than 15 days) was verified, with a sensitivity of 56% and a specificity of 92% when the ratio was higher than 1.26.
  
  
  CONCLUSIONS
  The MCA PI of fetuses with growth restriction should be assessed. The UA PI/MCA ratio is predictive of a nonreactive computerized cardiotocography trace and of prolonged neonatal hospitalization.
authors.affiliation: Institute of Gynecological Sciences, Perinatology and Child Health, University, Rome, Italy. jjpiazze2000@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Piazze
authors.forename: F
authors.initials: F
authors.lastname: Padula
authors.forename: A
authors.initials: A
authors.lastname: Cerekja
authors.forename: E V
authors.initials: EV
authors.lastname: Cosmi
authors.forename: M M
authors.initials: MM
authors.lastname: Anceschi
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D015148:Cardiotocography; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced; D007231:Infant, Newborn; D020768:Middle Cerebral Artery / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics; D011673:Pulsatile Flow / Q000502:physiology*; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000502:physiology*