Novel role and regulation of the interleukin-1 receptor associated kinase (IRAK) family proteins.
The interleukin-1 receptor associated kinases (IRAKs) sit at the bottle neck for the Toll-like-receptor (TLR) mediated signal transduction process controlling host innate immune response. However, the exact role and regulation of IRAKs are still in the early stage and not fully understood. This review intends to summarize the recent advancement in this important topic and point out areas that need further intensive investigation.
Huang
Ying Su
YS
Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Misior
Anna
A
Li
Li Wu
LW
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D053592:Interleukin-1 Receptor-Associated Kinases; D047908:Intracellular Signaling Peptides and Proteins / Q000145:classification / Q000276:immunology* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000145:classification / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction
D047908:Intracellular Signaling Peptides and Proteins; D053592:Interleukin-1 Receptor-Associated Kinases; D017346:Protein Serine-Threonine Kinases