title: Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta.
abstract: The acute control of human placental lactogen (hPL) and chorionic gonadotrophin (hCG) secretion by the placenta remains elusive. The in vitro release of both hormones can be stimulated by calcium inflow and by albumin. To investigate the placental secretory response to putative ligand(s) present in the maternal circulation, we evaluated the coupling of the hPL and hCG releases from term placenta with intracellular signaling pathways. Addition of NaF, forskolin or sodium nitroprusside, activators of the inositol phosphates (IPs), cAMP and cGMP pathways, significantly increased their respective messengers in villous explants but failed to affect the hPL and hCG releases from syncytiotrophoblast. By contrast, albumin did not modify the IPs, cAMP and cGMP villous content but significantly stimulated the placental hormonal release. These data suggest that the hPL and hCG secretion is not regulated through the IPs, cAMP and cGMP signaling pathways.
authors.affiliation: Laboratory of Experimental Hormonology, Université Libre de Bruxelles, 808 Lennik Road, Campus Erasme, CP 626, Brussels 1070, Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lambot
authors.forename: Lambot
authors.initials: L
authors.lastname: Nathalie
authors.forename: Philippe
authors.initials: P
authors.lastname: Lebrun
authors.forename: Lebrun
authors.initials: L
authors.lastname: Philippe
authors.forename: Christine
authors.initials: C
authors.lastname: Delporte
authors.forename: Delporte
authors.initials: D
authors.lastname: Christine
authors.forename: Carine
authors.initials: C
authors.lastname: De Vriese
authors.forename: De Vriese
authors.initials: de V
authors.lastname: Carine
authors.forename: Josiane
authors.initials: J
authors.lastname: Delogne-Desnoeck
authors.forename: Delogne-Desnoeck
authors.initials: DD
authors.lastname: Josiane
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Vanbellinghen
authors.forename: Vanbellinghen
authors.initials: V
authors.lastname: Anne Marie
authors.forename: Guy
authors.initials: G
authors.lastname: Graff
authors.forename: Graff
authors.initials: G
authors.lastname: Guy
authors.forename: Sylvain
authors.initials: S
authors.lastname: Meuris
authors.forename: Meuris
authors.initials: M
authors.lastname: Sylvain
mesh_terms: D006063:Chorionic Gonadotropin / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D010920:Placenta / Q000187:drug effects / Q000502:physiology*; D010928:Placental Lactogen / Q000378:metabolism*; D011247:Pregnancy; D015398:Signal Transduction; D012969:Sodium Fluoride / Q000494:pharmacology
chemical_list: D006063:Chorionic Gonadotropin; D007295:Inositol Phosphates; D009599:Nitroprusside; D005576:Colforsin; D012969:Sodium Fluoride; D010928:Placental Lactogen; D000242:Cyclic AMP; D006152:Cyclic GMP