title: Impairment of Trk-neurotrophin receptor by the serum of a patient with subacute sensory neuropathy.
abstract: BACKGROUND
  Paraneoplastic peripheral neuropathy is sometimes associated with unidentified neuronal autoantibodies.
  
  
  OBJECTIVE
  To examine the effects of serum from a patient with subacute sensory axonopathy on the function of the Trk high-affinity nerve growth factor receptor.
  
  
  METHODS
  An 86-year-old man with sensory neuropathy exhibiting an autoantibody to Trk.
  
  
  METHODS
  Immunoblot analyses of the brain homogenates and immunoprecipitation were performed with human sera. We further examined the effect of sera on nerve growth factor-induced neurite outgrowth and Trk autophosphorylation.
  
  
  RESULTS
  The patient showed sensory nerve axonopathy without well-known paraneoplastic autoantibodies. His serum inhibited nerve growth factor-induced neurite outgrowth and Trk autophosphorylation in PCtrk cells. Moreover, the patient's serum, but not control serum, immunoprecipitated Trk and recognized Trk in brain homogenates as well as in Trk immunoprecipitates.
  
  
  CONCLUSIONS
  These data strongly suggest that an anti-Trk autoantibody might cause subacute sensory neuropathy.
authors.affiliation: Author Affiliations: Department of Neurology, Fujita Health University School of Medicine, Aichi, Japan. tmutoh@fujita-hu.ac.jp
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Mutoh
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tachi
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Yano
authors.forename: Takateru
authors.initials: T
authors.lastname: Mihara
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D009474:Neurons / Q000378:metabolism; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology* / Q000503:physiopathology; D020917:Receptor, trkA / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D020917:Receptor, trkA