title: No association between attention-deficit hyperactivity disorder and catechol-O-methyltransferase gene in Chinese.
abstract: Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder(ADHD). Since catechel-O-methyltransferase (COMT) is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems,it is possible that COMT may play a role in ADHD. To test this hypothesis, we used two family-based analyses,the transmission disequilibrium test (TDT) and the haplotype-based haplotype relative risk (HHRR), to examine the possible association between COMT gene and DSM-IV-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT (chi2 = 1.03, df=1, P > 0.05) and HHRR (chi2 = 1.08, df = 1, P > 0.05) analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Our data suggested that there was no association between ADHD and the COMT gene in the Chinese population.
authors.affiliation: Department of Genetics, Shanghai Mental Health Center, Shanghai 200030, China. jiangsanduo@163.com
authors.forename: San-Duo
authors.initials: SD
authors.lastname: Jiang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Wu
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhang
authors.forename: Guo-Mei
authors.initials: GM
authors.lastname: Tang
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Qian
authors.forename: Dong-Xiang
authors.initials: DX
authors.lastname: Wang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male
chemical_list: D002394:Catechol O-Methyltransferase