[Expression of S100-labeled dendritic cells in glottic squamous cell carcinoma and its correlation to prognosis].
OBJECTIVE
Dendritic cells (DCs) are the most important antigen-presenting cells, and can synthesize and secrete S100 protein. This study was designed to investigate the expression of S100-labeled DCs in glottic squamous cell carcinoma, and analyze its correlation to the prognosis.


METHODS
The expression of S100-labeled DCs in peritumoral tissues of 111 specimens of gllotic squamous cell carcinoma was detected by immunohistochemistry; 17 specimens of normal tissues were used as control. The correlation of S100-labeled DCs expression to prognosis of the 111 patients was evaluated.


RESULTS
The positive rates of S100-labeled DCs were 51.35% (57/111) in peritumoral tissues of gllotic squamous cell carcinoma, and 0 in normal tissues. The 5-year survival rate was significantly higher in S100-positive group than in S100-negative group (72.31% vs. 53.91%, P=0.030).


CONCLUSIONS
The glottic squamous cell carcinoma patients with obvious infiltration of S100-labeled DCs may achieve good prognosis.
Chen
Wen-Kuan
WK
Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P. R. China. chenwenkuan@163.com
Chen
Fu-Jin
FJ
Zeng
Zong-Yuan
ZY
Wu
Guo-Hao
GH
Guo
Zhu-Ming
ZM
Wei
Mao-Wen
MW
Yang
An-Kui
AK
Zhang
Quan
Q
He
Jie-Hua
JH
Hou
Jing-Hui
JH
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D005931:Glottis; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism*; D015996:Survival Rate
D009418:S100 Proteins