Thresholds as a unifying theme in regulatory toxicology.
The scientific basis for the US Food and Drug Administration (FDA) threshold of regulation is discussed in relation to its toxicological testing recommendations for food contact substances and the existing methods it employs for exposure estimation. A case is made that the FDA's threshold of regulation is a natural extension of its toxicity testing regime. The genetic toxicity tests recommended in the exposure-based toxicological testing framework for food contact substances are examined regarding their ability to predict positively carcinogens of varying potency. In addition, the computational toxicology program MULTICASE v. 3.1 is also examined for its ability to predict positively carcinogens of varying potency. It is concluded that MULTICASE can provide equivalent results to genetic toxicity tests at the lowest dietary concentrations.
Cheeseman
M A
MA
Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA. Mitchell.Cheeseman@FDA.Gov
D015197:Carcinogenicity Tests; D002274:Carcinogens, Environmental / Q000633:toxicity; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects; D005506:Food Contamination; D006801:Humans; D009152:Mutagenicity Tests; D018570:Risk Assessment / Q000379:methods; D012984:Software; D013329:Structure-Activity Relationship; D020711:Threshold Limit Values; D018675:Toxicity Tests; D014481:United States; D014486:United States Food and Drug Administration / Q000592:standards*
D002274:Carcinogens, Environmental