title: Anti-malarial activity of Baylis-Hillman adducts from substituted 2-chloronicotinaldehydes.
abstract: New Baylis-Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity.
authors.affiliation: Organic Chemistry Division-II, Indian Institute of Chemical Technology,Uppal Road, Tarnaka, Hyderabad 500007, India.
authors.forename: P
authors.initials: P
authors.lastname: Narender
authors.forename: U
authors.initials: U
authors.lastname: Srinivas
authors.forename: B
authors.initials: B
authors.lastname: Gangadasu
authors.forename: Sukla
authors.initials: S
authors.lastname: Biswas
authors.forename: V Jayathirtha
authors.initials: VJ
authors.lastname: Rao
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D002712:Chlorides; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D000962:Antimalarials; D002712:Chlorides; C014785:3-pyridinaldehyde