The last 100 years of sepsis.
Over the last 100 years, huge advances have been made in the field of sepsis in terms of pathophysiology, epidemiology, diagnosis, monitoring, and therapeutics. Here, we offer our perspective of the key changes and current situation in each of these areas. Despite these changes, mortality rates remain unacceptably high and continued progress, particularly in early diagnosis and therapy, is urgently needed.
Vincent
Jean-Louis
JL
Department of Intensive Care, Erasme University Hospital, Brussels, Belgium 1070. jlvincen@ulb.ac.be
Abraham
Edward
E
D049673:History, 20th Century; D006801:Humans; D018805:Sepsis / Q000175:diagnosis / Q000266:history* / Q000628:therapy