title: Radial glia cells are candidate stem cells of ependymoma.
abstract: Tumors of the same histologic type often comprise clinically and molecularly distinct subgroups; however, the etiology of these subgroups is unknown. Here, we report that histologically identical, but genetically distinct, ependymomas exhibit patterns of gene expression that recapitulate those of radial glia cells in the corresponding region of the central nervous system. Cancer stem cells isolated from ependymomas displayed a radial glia phenotype and formed tumors when orthotopically transplanted in mice. These findings identify restricted populations of radial glia cells as candidate stem cells of the different subgroups of ependymoma, and they support a general hypothesis that subgroups of the same histologic tumor type are generated by different populations of progenitor cells in the tissues of origin.
authors.affiliation: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
authors.forename: Helen
authors.initials: H
authors.lastname: Poppleton
authors.forename: Christine
authors.initials: C
authors.lastname: Fuller
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Su
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Liu
authors.forename: Patricia
authors.initials: P
authors.lastname: Jensen
authors.forename: Susan
authors.initials: S
authors.lastname: Magdaleno
authors.forename: James
authors.initials: J
authors.lastname: Dalton
authors.forename: Christopher
authors.initials: C
authors.lastname: Calabrese
authors.forename: Julian
authors.initials: J
authors.lastname: Board
authors.forename: Tobey
authors.initials: T
authors.lastname: Macdonald
authors.forename: Jim
authors.initials: J
authors.lastname: Rutka
authors.forename: Abhijit
authors.initials: A
authors.lastname: Guha
authors.forename: Amar
authors.initials: A
authors.lastname: Gajjar
authors.forename: Tom
authors.initials: T
authors.lastname: Curran
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gilbertson
mesh_terms: D000818:Animals; D004806:Ependymoma / Q000235:genetics / Q000473:pathology*; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009457:Neuroglia / Q000473:pathology*; D013234:Stem Cells / Q000473:pathology*