title: Solid-phase, multicomponent reactions of methyleneaziridines: synthesis of 1,3-disubstituted propanones.
abstract: [reaction: see text] Polymer-supported methyleneaziridines undergo ring opening by Grignard reagents under copper catalysis to yield metalloenamines which are alkylated in situ to yield ketimines. Filtration and washing of these Merrifield resin-bound intermediates prior to hydrolysis provides the corresponding 1,3-disubstituted propanones in a high state of purity without recourse to column chromatography.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Margathe
authors.forename: Michael
authors.initials: M
authors.lastname: Shipman
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Smith