TORCs rev up gluconeogenesis.
Transducer of regulated CREB activity (TORC) proteins promote transactivation by the cAMP response element binding protein (CREB) and mediate effects of cAMP agonists on gene expression. Koo et al. now report that TORC phosphorylation and nuclear/cytoplasmic shuttling play a key role in the regulation of gluconeogenesis by cAMP. Control of TORC phosphorylation and function may integrate the effects of multiple factors involved in metabolic control, including cAMP agonists, insulin, and AMP kinases. TORCs, and kinases affecting TORC function, are promising new therapeutic targets for the treatment of diabetes mellitus.
Patil
Sandip
S
Department of Medicine and Physiology, University of Illinois at Chicago College of Medicine, Medical Research Service, USA.
Unterman
Terry G
TG
D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005943:Gluconeogenesis; D010750:Phosphoproteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D017362:Cyclic AMP Response Element-Binding Protein; D010750:Phosphoproteins; D014157:Transcription Factors