Influence of hydrophobe on the release behavior of vinyl acetate miniemulsion polymerization.
Poly(vinyl acetate) (PVAc) nanoparticles containing antibiotic have been prepared by miniemulsion polymerization. To compare the effect of hydrophobe types, hexadecane and poly(vinyl acetate) were used as hydrophobe. The particle characteristics as the manufacturing condition were examined by particle size analyzer. As a result, the diameter of PVAc latexes was adjusted between 80 and 260 nm by homogenization conditions and amounts of surfactant. Also, the miniemulsion by using hexadecane showed the more long shelf stability and led to the more small particle size after polymerization, as compared with the case of using poly(vinyl acetate). This indicated that the use of poly(vinyl acetate) as a hydrophobe could not make the stable emulsion, but it could avoid volatile organic chemical problems in the final product. From the release profile of drug through UV spectra, the drug release was very slow and it could be seen that the release of drug encapsulated with PVAc was occurred with the polymer degradation.
Park
Soo-Jin
SJ
Advanced Materials Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusong, Daejeon 305-600, Republic of Korea. psjin@krict.re.kr
Kim
Ki-Seok
KS
D004337:Drug Carriers / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D049329:Nanostructures; D011108:Polymers / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors; D014466:Ultraviolet Rays; D014753:Vinyl Compounds / Q000737:chemistry*
D004337:Drug Carriers; D011108:Polymers; D011145:Polyvinyls; D013501:Surface-Active Agents; D014753:Vinyl Compounds; C013215:polyvinyl acetate; C011566:vinyl acetate