Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine.
To investigate the relationship between 48 bp variant number tandem repeat polymorphism in dopamine D4 receptor gene and response to clozapine in schizophrenic patients, the authors included 81 inpatients with a DSM-IV diagnosis of schizophrenia and patients meeting criteria for refractory to treatment were excluded. This study found that the frequencies of five 48 bp repeats homozygous genotype and five 48 bp repeats allele were significantly less in the responders than the nonresponders, which divided by improving total schizophrenic symptom. The results of this study suggest that inherited variants of D4 may explain some of the interindividual variation seen in patient response to clozapine.
Zhao
Ai-Ling
AL
Departmernt of Psychiatry, The Second Xiangya Hospital Central South University, Changsha, Hunan, PR China.
Zhao
Jing-Ping
JP
Zhang
Yu-Hu
YH
Xue
Zhi-Min
ZM
Chen
Jin-Dong
JD
Chen
Xiao-Gang
XG
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D010597:Pharmacogenetics / Q000379:methods; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012333:RNA, Messenger / Q000378:metabolism; D050638:Receptors, Dopamine D4 / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics
D014150:Antipsychotic Agents; D012333:RNA, Messenger; D050638:Receptors, Dopamine D4; D003024:Clozapine