K65R and Y181C are less prevalent in HAART-experienced HIV-1 subtype A patients.
The vast majority of HIV-1 infections globally are caused by subtype A or C, although little is known about their drug resistance profiles. We found that HAART-experienced patients infected with subtype A had a lower prevalence of K65R and Y181C than those with subtypes B or C, despite similar exposure to antiretroviral agents that select for these mutations. If confirmed, this information may be important in the planning of antiretroviral regimens in patients infected with HIV-1 subtype A.
Gupta
Ravindra K
RK
Department of Infection, Guy's and St Thomas' NHS Foundation Trust (GSTT), London, UK.
Chrystie
Ian L
IL
O'Shea
Siobhan
S
Mullen
Jane E
JE
Kulasegaram
Ranjababu
R
Tong
Cheuk Y W
CY
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D024921:Drug Resistance, Multiple, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation; D012189:Retrospective Studies