Clinical value of epidermal growth factor receptor expression in primary breast cancer.
EGFR expression in primary breast cancer has been extensively investigated for its prognostic and predictive value. However overall there is no consensus on its potential to guide such prognostication. This is largely because of the great heterogeneity in study designs and methods used to assay the EGFR protein. The impetus to standardize such studies is much needed as there are now several tyrosine kinase inhibitors directed against the EGF receptor and phase II trials are showing significant promise.
Rampaul
R S
RS
Nottingham Breast Institute, University of Nottingham, Nottingham City Hospital, NHS Trust, Nottingham, UK. mszrsr@nottingham.ac.uk
Pinder
S E
SE
Nicholson
R I
RI
Gullick
W J
WJ
Robertson
J F
JF
Ellis
I O
IO
D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis
D066246:ErbB Receptors