[Effects on development of the testicle in diet-induced obesity rats].
OBJECTIVE
We established diet-induced obesity animal model and observed the influence of obesity on testicle of the male rats.


METHODS
Rats in model group were fed with fat-enriched diet for 6 weeks. We measured the body weight and the testis weight and observed the development of testicle by microscope, and compared with those of control group. Meanwhile, we measured the serum levels of testosterone (T) and estradiol (E2).


RESULTS
The average body weight in model group rats was higher 29% than that in control group at 6 weeks old, 30% at 9 weeks old. We observed under microscope that most of the convoluted seminiferous tubule developed no good in model group, the 4 layer cells was sparse and the arrangement of them was not in order. The testosterone to estradiol ratios(T/E2) in model group was significant lower then that of control group (P < 0.05).


CONCLUSIONS
The fat-enriched fat diet can induce obesity. It influenced the development of the testicle. This probably related to decrease of the testosterone to estradiol ratios.
Yang
Ai-Jun
AJ
Department of Pediatrics, Beijing Friendship Hospital Affiliate of Capital University of Medical Sciences, Beijing 100050, China.
Cui
Hong
H
Cui
Yan
Y
Ye
Hui-Chu
HC
Li
Yuhang
Y
D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood; D008297:Male; D009765:Obesity / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D051381:Rats; D013737:Testis / Q000254:growth & development* / Q000648:ultrastructure; D013739:Testosterone / Q000097:blood; D014886:Weaning
D004041:Dietary Fats; D013739:Testosterone; D004958:Estradiol