The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans.
Farnesol, a quorum sensing (QS) signal, is produced by Candida albicans during high density growth and has been found to inhibit morphogenesis. This QS auto-inducing signal was discovered to increase amino acid incorporation by C. albicans when concentrations of farnesol increased to 10 microg/mL in yeast nitrogen broth. Farnesol concentrations greater than 10 microg/mL abolished the enhanced incorporation, and the magnitude of the increased incorporation was dependent on cell-surface hydrophobicity.
Braun
Phyllis C
PC
Biology Department, Fairfield University, CT 06824, USA. pcbraun@mail.fairfield.edu
D000596:Amino Acids / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D002473:Cell Wall / Q000378:metabolism / Q000502:physiology*; D003470:Culture Media; D005204:Farnesol / Q000494:pharmacology*; D015966:Gene Expression Regulation, Fungal; D057927:Hydrophobic and Hydrophilic Interactions; D015398:Signal Transduction
D000596:Amino Acids; D003470:Culture Media; D005204:Farnesol