title: Evaluation of coated oxygenators in cardiopulmonary-bypass systems and their impact on neurocognitive function.
abstract: BACKGROUND
  Coronary artery bypass graft surgery (CABG) using cardiopulmonary bypass (CPB) is assumed to be associated with a decline of neurocognitive functions. This study was designed to analyse the neurocognitive function of patients with coronary heart disease before and after CABG and to determine possible protective effects of oxygenator surface coating on neurological outcome.
  
  
  METHODS
  Forty patients scheduled for selective CABG were prospectively randomized into two groups of 20 patients each according to the type of hollow-fibre membrane oxygenator used. Non-coated oxygenators (Group A) were compared to phosphorylcholine (PC)coated oxygenators (Group B). A battery of six neurological tests was administered preoperatively, 7-10 days and 4-6 months after surgery.
  
  
  RESULTS
  One patient of Group A suffered from a perioperative stroke and died on postoperative day 3, presumably because of sudden heart failure. Two patients of Group A (10%) developed a symptomatic transitory delirious psychotic syndrome (STPT) on postoperative days 3 and 5. None of the patients of Group B had perioperative complications. The test analysis revealed a trend of declined neurocognitive function early after CABG, but did not show any difference in neurocognitive outcome between the two groups.
  
  
  CONCLUSIONS
  PC coating of the oxygenators did not show any significant benefit on neurocognitive function after CABG using CPB.
authors.affiliation: Department of Cardiac Surgery, University of Rostock, Rostock, Germany.
authors.forename: Amir
authors.initials: A
authors.lastname: Khosravi
authors.forename: Christian A
authors.initials: CA
authors.lastname: Skrabal
authors.forename: Bernd
authors.initials: B
authors.lastname: Westphal
authors.forename: Guenther
authors.initials: G
authors.lastname: Kundt
authors.forename: Brigitte
authors.initials: B
authors.lastname: Greim
authors.forename: Erwin
authors.initials: E
authors.lastname: Kunesch
authors.forename: Andreas
authors.initials: A
authors.lastname: Liebold
authors.forename: Gustav
authors.initials: G
authors.lastname: Steinhoff
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000592:standards* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000209:etiology / Q000517:prevention & control; D009483:Neuropsychological Tests; D010107:Oxygenators, Membrane / Q000009:adverse effects* / Q000592:standards; D010767:Phosphorylcholine / Q000627:therapeutic use; D020011:Protective Agents / Q000592:standards / Q000627:therapeutic use
chemical_list: D020099:Coated Materials, Biocompatible; D020011:Protective Agents; D010767:Phosphorylcholine