title: Nephron-sparing surgery for de novo renal cell carcinoma in allograft kidneys.
abstract: Renal cell carcinomas account for 4.6% of post-transplant cancers, 10% of which occur in allograft kidneys. We report three such cases among kidney grafts that were performed or followed from 1970 to 2004. In all patients, we performed a partial allograft nephrectomy after consideration of the tumor size, location, and absence of metastases and local extension. Renal function has remained stable, and there has been no sign of graft rejection, tumor recurrence or metastases. The surgery was technically feasible without exposing the patients to increased postoperative risks. The lateral, peripherally located tumor allowed excision without renal hilar dissection or entry into the collecting system. In agreement with data emerging from the literature, the present cases confirm that even in the setting of long-standing immunosuppression, de novo RCC of the kidney graft warrants a minimally invasive approach to spare patients graft loss and return to hemodialysis.
authors.affiliation: Department of Urology, Tenon Hospital, Paris, France. s_moudouni@yahoo.fr
authors.forename: S Mohamed
authors.initials: SM
authors.lastname: Moudouni
authors.forename: Mohamed
authors.initials: M
authors.lastname: Tligui
authors.forename: Jean Dominique
authors.initials: JD
authors.lastname: Doublet
authors.forename: Francois
authors.initials: F
authors.lastname: Haab
authors.forename: Bernard
authors.initials: B
authors.lastname: Gattegno
authors.forename: Philippe
authors.initials: P
authors.lastname: Thibault
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009399:Nephrons; D015898:Tomography Scanners, X-Ray Computed; D014184:Transplantation, Homologous