One-step labelling of sphingolipids via a scrambling cross-metathesis reaction.
The alkyl chain in the backbone of sphingosine derivatives can be exchanged with functionalised (labelled) side chains in a single step under cross-metathesis reaction conditions.
Nussbaumer
Peter
P
Novartis Institutes for BioMedical Research, Brunnerstrasse 59, Vienna, A-1235, Austria.
Ettmayer
Peter
P
Peters
Carsten
C
Rosenbeiger
Daniela
D
Högenauer
Klemens
K
D002518:Ceramides / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D008697:Methane / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D013109:Sphingomyelins / Q000737:chemistry*; D013110:Sphingosine / Q000737:chemistry
D002518:Ceramides; D003432:Cross-Linking Reagents; D013109:Sphingomyelins; D013110:Sphingosine; D008697:Methane