title: Effect of chronic alcoholism on male fertility hormones and semen quality.
abstract: OBJECTIVE
  To evaluate the effects of chronic alcoholism on the male fertility hormones and quality of semen.
  
  
  METHODS
  Non-probability purposive clinical study.
  
  
  METHODS
  Addiction treatment center and an academic research environment.
  
  
  METHODS
  Sixty-six alcoholics free from smoking and drug abuse who consumed a minimum of 180 mL of alcohol per day (brandy and whisky, both 40%-50% alcohol content) for a minimum of 5 days per week for > or =1 year were included. Thirty nonsmoking nonalcoholics were selected as controls.
  
  
  METHODS
  Before starting the addiction treatment for alcoholics, venous blood and semen samples were collected.
  
  
  METHODS
  Complete blood counts, biochemical parameters, levels of the male fertility hormones FSH, LH, T, PRL, P, and E2 in blood, and semen parameters.
  
  
  RESULTS
  In alcoholics, FSH, LH, and E2 levels were significantly increased, and T and P levels were significantly decreased. No significant change was noted in PRL levels. Semen volume, sperm count, motility, and number of morphologically normal sperm were significantly decreased.
  
  
  CONCLUSIONS
  Chronic alcohol consumption has a detrimental effect on male reproductive hormones and on semen quality.
authors.affiliation: The Tamil Nadu Dr. M.G.R. Medical University, Chennai, India. muthusamikr@yahoo.co.in
authors.forename: K R
authors.initials: KR
authors.lastname: Muthusami
authors.forename: P
authors.initials: P
authors.lastname: Chinnaswamy
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000473:pathology*; D016009:Chi-Square Distribution; D005298:Fertility / Q000502:physiology*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000473:pathology; D008297:Male; D012661:Semen / Q000166:cytology* / Q000378:metabolism*
chemical_list: D012739:Gonadal Steroid Hormones