[Effects of lactone I from Atractylodes macrocephala Koidz on cytokines and proteolysis-inducing factors in cachectic cancer patients].
OBJECTIVE
To observe the effect of lactone I from Atractylodes macrocephala Koidz (LAMK I) on the cytokines and proteolysis-inducing factors (PIF) in cachectic cancer patients.


METHODS
Sixty-four cachectic cancer patients were randomized into two groups, namely LAMK I group and FOE (fish oil-enriched nutritional supplementation) treatment group. The appetite, body weight changes, mid-arm muscle circumference (MAMC), and KPS scores were recorded 3 and 7 weeks after the treatment. Immunohistochemistry was used to analyze the changes in the cytokines interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-alpha and Western blotting employed to examine the changes of PIF after the treatment.


RESULTS
The patients' appetite and MAMC in LAMKI group was better than those of patients in FOE group, and the serum IL-1 and TNF-alpha levels and urine PIF level were significantly lower than those of FOE group. Body weight and serum IL-6 level were not significantly different between the two groups.


CONCLUSIONS
Lactone I from Atractylodes macrocephala Koidz can be beneficial for treating cancer cachexia.
Liu
Yi
Y
Department of Traditional Chinese Medicine, First affiliated Hospital of Xian Jiaotong University, Xi'an 710061, China. liuyi.jiaotong@163.com
Ye
Feng
F
Qiu
Gen-quan
GQ
Zhang
Mei
M
Wang
Rui
R
He
Qun-ying
QY
Cai
Yun
Y
D000328:Adult; D000368:Aged; D031174:Atractylodes / Q000737:chemistry*; D002100:Cachexia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics; D007783:Lactones / Q000302:isolation & purification / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008517:Phytotherapy; D011509:Proteoglycans / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D007783:Lactones; D011509:Proteoglycans; D014409:Tumor Necrosis Factor-alpha; C042057:proteolysis-inducing peptide