Bending in the right direction.
The success of a new Monte Carlo algorithm in describing sequence-specific DNA bending is reported. The approach offers the possibility of improved treatments of "indirect readout" effects in the prediction of transcription factor binding sites.
Siggers
Trevor
T
Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Columbia University, 1130 St. Nicholas Avenue, ICRB, Mail Box 200, New York, New York 10032, USA.
Silkov
Tonya
T
Honig
Barry
B
D000465:Algorithms; D001482:Base Composition; D020029:Base Pairing; D001665:Binding Sites; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D004279:DNA, Viral / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009010:Monte Carlo Method; D009690:Nucleic Acid Conformation; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation
D004279:DNA, Viral; D009856:Oncogene Proteins, Viral; C069102:oncogene protein E2, Human papillomavirus type 18