title: Acute cholestatic hepatitis probably associated with risperidone.
abstract: OBJECTIVE
  Risperidone is an atypical neuroleptic drug widely used due to the lower incidence and severity of hepatic adverse effects in comparison to phenothiazines. Although idiosyncratic reversible hepatotoxicity may occur in association with risperidone, the interaction with fluoxetine might increase the risk of toxic liver injury in a vulnerable patient.
  
  
  RESULTS
  We present a case of acute cholestatic hepatitis probably associated with the use of risperidone after only a few days of therapy in a patient also treated with fluoxetine. The patient, a 64-year-old male, developed a rapid increase in liver enzymes after starting treatment with only four doses of risperidone 2 mg/day.
  
  
  CONCLUSIONS
  We recommend obtaining baseline liver function tests before starting risperidone and regular monitoring to screen patients for liver damage during therapy whenever a patient is also receiving fluoxetine.
authors.affiliation: Alicante University General Hospital, Spain. paquillinares@eresmas.com
authors.forename: Francisca
authors.initials: F
authors.lastname: Llinares Tello
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández Prats
authors.forename: Nuria
authors.initials: N
authors.lastname: Bosacoma Ros
authors.forename: Enrique
authors.initials: E
authors.lastname: Pérez Martínez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Climent Grana
authors.forename: José Noé
authors.initials: JN
authors.lastname: Navarro Polo
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Ordovás Baines
mesh_terms: D000208:Acute Disease; D014150:Antipsychotic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone