Synthesis and antiinflammatory activity of 1,5-diarylimidazoles.
A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed PGE2 production. 1,5-Diarylimidazoles were obtained from imimes and p-toluenesulfonylmethyl cyanide (TosMIC). Imines were prepared from commercially available amines and aldehydes. Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4-methylsulfonylphenyl)imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed PGE2 production.
Tuyen
Truong Ngoc
TN
College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea.
Sin
Kwang-Seog
KS
Kim
Hyun Pyo
HP
Park
Haeil
H
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice
D000893:Anti-Inflammatory Agents; D007093:Imidazoles