Obstetric complications in Marfan syndrome.
OBJECTIVE
To investigate the obstetric maternal and neonatal outcome of pregnancy in women with Marfan syndrome.


METHODS
Retrospective observational multi-center study based on congenital heart disease registry.


RESULTS
Sixty-three of the 122 enrolled women with Marfan syndrome had been pregnant 142 times (including 111 pregnancies>20 weeks, 28 (20%) miscarriages and 3 elective abortions). In 40% of all completed pregnancies an obstetric and/ or neonatal complication occurred. The most important complications were an increased percentage of premature deliveries (n=17, 15%) mainly due to preterm premature rupture of membranes and cervical incompetence and a markedly increased combined fetal and neonatal mortality of 7.1%. An obstetric and/or neonatal complication occurred in a similar proportion of pregnancies in women with a diagnosis of Marfan syndrome before pregnancy versus women with a diagnosis of Marfan syndrome after pregnancy (39% vs. 41%, p=0.85, respectively).


CONCLUSIONS
In addition to cardiovascular complications, pregnancy in women with Marfan syndrome is associated with a high rate of premature deliveries, preterm premature rupture of membranes and increased mortality in the offspring.
Meijboom
Lilian J
LJ
Department of Cardiology, Rm B2-240, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, and Department of Cardiology, Radboud Hospital Nijmegen, The Netherlands.
Drenthen
Willem
W
Pieper
Petronella G
PG
Groenink
Maarten
M
van der Post
Joris A M
JA
Timmermans
Janneke
J
Voors
Adriaan A
AA
Roos-Hesselink
Jolien W
JW
van Veldhuisen
Dirk J
DJ
Mulder
Barbara J M
BJ
D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D000368:Aged; D005260:Female; D005865:Gestational Age; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal