An approach to heterobifunctional poly(ethyleneglycol) bioconjugates.
A family of differentially substituted poly(ethyleneglycol) building blocks has been assembled from commercially available material. Their utility is demonstrated by formation of amino acid conjugates, image contrast agents, gold nanoparticles, and functional antibody conjugates. Application in the cellular trafficking of antitumoral agent conjugates is expected.
Li
Jane
J
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Crasto
Curtis F
CF
Weinberg
James S
JS
Amiji
Mansoor
M
Shenoy
Dinesh
D
Sridhar
Srinivas
S
Bubley
Glenn J
GJ
Jones
Graham B
GB
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000906:Antibodies / Q000737:chemistry; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D001665:Binding Sites; D001692:Biological Transport; D006041:Goats; D007074:Immunoglobulin G; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics
D000596:Amino Acids; D000906:Antibodies; D000970:Antineoplastic Agents; D007074:Immunoglobulin G; D011092:Polyethylene Glycols