Gender and COPD in patients attending a pulmonary clinic.
OBJECTIVE
To compare gender differences in the clinical expression of COPD patients attending a pulmonary clinic.


METHODS
We compared 53 FEV1-matched men and women with COPD attending a pulmonary clinic. We studied age, smoking pack-years history, Pa(O2), Pa(CO2), functional residual capacity, body mass index (BMI), dyspnea, 6-min walk distance (6MWD), health-related quality of life, presence of comorbidities, and exacerbations in the previous year.


RESULTS
Women were younger (57 years vs 65 years, p < 0.05), smoked less (48 pack-years vs 69 pack-years, p < 0.05), had better Pa(O2) (74 mm Hg vs 67 mm Hg, p < 0.05), lower Pa(CO2) (40 mm Hg vs 45 mm Hg, p < 0.05), lower BMI (25 vs 28, p < 0.05), more exacerbations in the last year (1 vs 0, p < 0.05), and fewer comorbidities (Charlson score 2 vs score 4, p < 0.05) than men. Even though women had the same FEV1, better oxygenation, better Pa(CO2), and fewer comorbidities, they performed poorer in walking distance (6MWD percentage of predicted, 87% vs 105%; p = 0.05), had worse quality-of-life scores (Saint George's Respiratory Questionnaire [SGRQ] symptoms score, 51 vs 41, p < 0.05; SGRQ activity score, 58 vs 47, p < 0.05), and had a higher degree of dyspnea (Modified Medical Research Council scale > 2, 28% vs 6%, p = 0.05).


CONCLUSIONS
In a population of patients with COPD attending a pulmonary clinic, there are gender-related differences in the clinical expression of COPD that need further attention.
de Torres
Juan P
JP
Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain. jupa65@hotmail.com
Casanova
Ciro
C
Hernández
Concepción
C
Abreu
Juan
J
Aguirre-Jaime
Armando
A
Celli
Bartolome R
BR
D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology*; D012129:Respiratory Function Tests; D017678:Sex Distribution; D012907:Smoking