title: The relation between progressive osteoarthritis of the knee and long term progression of osteoarthritis of the hand, hip, and lumbar spine.
abstract: BACKGROUND
  The association between progression of knee osteoarthritis and progression of osteoarthritis at sites distant from the knee is unclear because of a lack of multisite longitudinal progression data.
  
  
  OBJECTIVE
  To examine the association between radiological progression of knee osteoarthritis and osteoarthritis of the hands, hips, and lumbar spine in a population based cohort.
  
  
  METHODS
  914 women had knee x rays taken 10 years apart, which were read for the presence of osteophytes and joint space narrowing (JSN). Progression status was available for hand, hip, and lumbar spine x rays over the same 8 to 10 year period. The association between progression of knee osteoarthritis and osteoarthritis at other sites was analysed using odds ratios (OR) and 95% confidence intervals (CI) in logistic regression models.
  
  
  RESULTS
  89 of 133 women had progression of knee osteoarthritis based on osteophytes, and 51 of 148 based on JSN definition. Progression of JSN in the knee was predicted by progression in lumbar spine disc space narrowing (OR = 2.9 (95% CI 1.2 to 7.5)) and hip JSN (OR = 2.0 (1.0 to 4.2)). No consistent effects were seen for hand osteoarthritis. The associations remained after adjustment for age and body mass index.
  
  
  CONCLUSIONS
  Progression of knee osteoarthritis is associated with progression of lumbar spine and hip osteoarthritis. This may have implications for trial methodology, the selection of patients for osteoarthritis research, and advice for patients on prognosis of osteoarthritis.
authors.affiliation: Twin Research and Genetic Epidemiology Unit, St. Thomas' Hospital, London, UK. geraldinehassett@bigpond.com
authors.forename: G
authors.initials: G
authors.lastname: Hassett
authors.forename: D J
authors.initials: DJ
authors.lastname: Hart
authors.forename: D V
authors.initials: DV
authors.lastname: Doyle
authors.forename: L
authors.initials: L
authors.lastname: March
authors.forename: T D
authors.initials: TD
authors.lastname: Spector
mesh_terms: D000328:Adult; D018450:Disease Progression; D004812:Epidemiologic Methods; D005260:Female; D005500:Follow-Up Studies; D006225:Hand / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000473:pathology; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging* / Q000473:pathology; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012720:Severity of Illness Index; D013122:Spinal Diseases / Q000000981:diagnostic imaging* / Q000473:pathology