Mechanisms of cytotoxicity of selected organogold(III) compounds.
The effects of a few cytotoxic organogold(III) compounds on ovarian A2780 human cancer cells were investigated in comparison to cisplatin and oxaliplatin. The tested compounds produced significant antiproliferative effects and promoted apoptosis to a greater extent than platinum drugs while causing only modest cell cycle modifications. The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase.
Coronnello
Marcella
M
Department of Pharmacology and Chemistry, University of Florence, Florence, Italy, Department of Chemistry, University of Sassari, Sassari, Italy. marcella.coronnello@unifi.it
Mini
Enrico
E
Caciagli
Barbara
B
Cinellu
Maria Agostina
MA
Bindoli
Alberto
A
Gabbiani
Chiara
C
Messori
Luigi
L
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D050607:Organogold Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C505986:(6-(1,1-dimethylbenzyl)-2,2'-bipyridine)(2,6-xylidine)gold(III); D000970:Antineoplastic Agents; D050607:Organogold Compounds; C505987:diacetato(2-(1,1-dimethylbenzyl)pyridine)gold(III)