title: Ontogenesis of mammals and gravity.
abstract: The results of the experiments with Wistar rats in microgravity and 2G hypergravity are summarized. Their analysis allows to conclude that adaptive potentials of adult animals in space flights lasting up to 1/50 of their life span are enough for maintenance of adequate reactions to acute and chronic stressors in the postflight period, rapid elimination of space-induced metabolic and structural alterations on return to Earth, maintenance of normal reproductive function after space flight. In embryological experiments it was demonstrated that during space flight it is possible not only to maintain physiological functions of an adult organism, but to form functions of a developing fetus. The animals that spent the portion of their prenatal development in space flight were capable to go through the entire cycle of postnatal development, up to sexual maturity and reproduction. In ground based centrifuge experiments with 2G it was demonstrated the possibility of realizing, under hypergravity, of all the main stages of prenatal and early postnatal development of rats: fertilization, embryon implantation, fetal development, birth and lactation of progeny. Exposure of rats to microgravity did not reduce their life span post flight. Alterations in biological age of animals were small.
authors.affiliation: RF State Scientific Center-Institute of Biomedical Problems of RAS, Moscow, Russia. lvserova@mail.ru
authors.forename: L V
authors.initials: LV
authors.lastname: Serova
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001522:Behavior, Animal; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000502:physiology; D018471:Hypergravity; D008136:Longevity; D008297:Male; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013026:Space Flight; D014893:Weightlessness