title: Detection and measurements of soluble intercellular adhesion molecules at implants and teeth: a comparative study.
abstract: BACKGROUND
  Adhesion molecules on endothelial cells and in the periodontal tissues control the immigration and retention of cells. The level of soluble intercellular adhesion molecules (sICAMs) has been used as a marker of the severity and/or extent of the inflammatory process in a wide range of pathologies, including periodontitis.
  
  
  OBJECTIVE
  This study was designed to detect and compare sICAM-1 at teeth and implants in relation to clinical periodontal and periimplant parameters.
  
  
  METHODS
  Regular recall patients with (1) implants and teeth, (2) implants, and (3) teeth were examined. Samples of sulcus fluid were collected from teeth and implants. The concentration of sICAM-1 was measured by enzyme-linked immunoabsorbent assay. Periodontal parameters were recorded after sampling.
  
  
  RESULTS
  The range of measured sICAM-1 was large (from below 100 to 1,200 ng/mL). The concentration of sICAM-1 was not different for teeth and implants but was significantly elevated in sites with positive bleeding on probing (BoP), namely, 571 ng/mL at teeth and 529 ng/mL at implants compared with 150 ng/mL and 169 ng/mL, respectively, with negative BoP. The regression analysis showed that the concentration of sICAM-1 was highly associated with positive BoP but was not dependent on the fluid volume.
  
  
  CONCLUSIONS
  A similarity of the sulcus fluid at teeth and implants was observed with regard to the detection of sICAM-1.
authors.affiliation: Department of Prosthodontics, University of Bern, Bern, Switzerland.
authors.forename: Ceyda
authors.initials: C
authors.lastname: Oezcakir
authors.forename: Mohammed
authors.initials: M
authors.lastname: Fekry-Khedr
authors.forename: Regina
authors.initials: R
authors.lastname: Mericske-Stern
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000276:immunology* / Q000378:metabolism; D012044:Regression Analysis; D016037:Single-Blind Method; D018709:Statistics, Nonparametric
chemical_list: D015921:Dental Implants; D018799:Intercellular Adhesion Molecule-1