title: [Clinical course of acute poisoning with olanzapine].
abstract: Olanzapine is a new atypical antipsychotic drug acting on different receptors. A variety of pharmacologic effects are responsible for toxicity and the variety of clinical symptoms seen in overdose: tachycardia, agitation or aggression, dysarthria, extrapyramidal dystonic effects, sedation or coma, small pupils, blurred vision, respiratory depression, hypotension. A retrospective analysis of clinical course of eight acute olanzapine intoxication treated at the Department of Clinical Toxicology Jagiellonian University Medical College is presented. CNS symptoms manifested in fluctuations between somnolence/coma and agitation/aggression and miosis were observed in most of the patients. Increased CPK activity was stated in the most of patients. All of the patients recovered, poisoning severity according PSS was moderate and severe.
authors.affiliation: Katedra Toksykologii Klinicznej i Srodowiskowej, Collegium Medicum, Uniwersytetu Jagiellońskiego, Krakowie.
authors.forename: Barbara
authors.initials: B
authors.lastname: Balicka-Slusarczyk
authors.forename: Jerzy
authors.initials: J
authors.lastname: Szczeklik
authors.forename: Dorota
authors.initials: D
authors.lastname: Szpak
authors.forename: Barbara
authors.initials: B
authors.lastname: Groszek
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000506:poisoning*; D001569:Benzodiazepines / Q000506:poisoning; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D000077152:Olanzapine; D011041:Poisoning / Q000150:complications / Q000175:diagnosis; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine