title: [Blood pressure control after a one year follow-up in high risk subject screened in occupational medicine].
abstract: OBJECTIVE
  To identify factors predicting the success or the failure of intervention on blood pressure in a population estimated at high risks.
  
  
  METHODS
  The program "Coeur 2001" has analysed the absolute cardiovascular risk (ACVR Framingham) in 107 371 voluntary French railways employees. In the company, were considered at high risk (HR), subjects for whom risk was > or = to the 95th percentile of the distribution of the observed ACVR by age range: ACVR > or = 4.5% before 35 years, 12% between 35 and 45 years and 19% beyond 45 years, i.e. a total of 4 190 subjects. These subjects were warned about their risk and advised to choose and consult a physician. A two-year follow up was planned. Identical data (risk factors, ACVR, type of management and therapies) were collected during the first consultation with the occupational physician (T0), one year later (T1) and two years later (T2).
  
  
  RESULTS
  Our work concerned 2376 employees at HR, consulting at T1. At T1, 54% of subjects were in the hight risk group (SHR) [48% when BP at T1 was < 140/90 mmHg and 62% when the BP was > or = 140/90 mmHg]. The mean decrease of the systolic BP (SBP) was 4 mmHg in the whole sample, 7.7 mmHg in subjects with normalised ACVR, and it remained stable in the group still at HR (-0.7 mmHg). At T0, blood pressure (BP) was > or = 140/90 mmHg in 55.8% of the patients and 38.4 at T1. This high BP was associated with higher frequency of diabetes (14 vs 7%) and overweight (BMI > or =30 kg/m2; 32.8 vs 19.7%). The percentage of treated hypertensive subjects had increased from 35 to 62% but one third of uncontrolled hypertensive subjects was treated by mono therapies at T1.
  
  
  CONCLUSIONS
  To keep BP under control is a difficult task in routine medicine. At T1, despite a more aggressive treatment, 38% of subjects at high risk were still hypertensive subjects.
authors.affiliation: INSERM U558, Faculté de médecine, Toulouse. camboujp@aol.com
authors.forename: J P
authors.initials: JP
authors.lastname: Cambou
authors.forename: C
authors.initials: C
authors.lastname: Cothereau
authors.forename: G
authors.initials: G
authors.lastname: Chatellier
authors.forename: P
authors.initials: P
authors.lastname: Saliou
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: L
authors.initials: L
authors.lastname: Capron
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D005602:France; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009790:Occupations; D010349:Patient Compliance; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents