title: Synthesis and antiinflammatory activity of 1,5-diarylimidazoles.
abstract: A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed PGE2 production. 1,5-Diarylimidazoles were obtained from imimes and p-toluenesulfonylmethyl cyanide (TosMIC). Imines were prepared from commercially available amines and aldehydes. Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4-methylsulfonylphenyl)imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed PGE2 production.
authors.affiliation: College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea.
authors.forename: Truong Ngoc
authors.initials: TN
authors.lastname: Tuyen
authors.forename: Kwang-Seog
authors.initials: KS
authors.lastname: Sin
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
authors.forename: Haeil
authors.initials: H
authors.lastname: Park
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice
chemical_list: D000893:Anti-Inflammatory Agents; D007093:Imidazoles