Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.
A series of dithiines were synthesized by cyclization of 4-(alkylamino)-4-oxobutanoic acids under the action of SOCl2. Their in vitro antibacterial and antifungal activities have been evaluated against reference strains and versus reference compounds. The so-called 'isoimides' 2a, 2b were totally inactive whereas some imides had low MICs for few bacteria and for few fungal microorganisms.
Zentz
F
F
Chimie et biologie des substances naturelles, FRE 2125 CNRS, 6, rue de l'Université, 29000 Quimper, France. zentz@univ-brest.fr
Labia
R
R
Sirot
D
D
Faure
O
O
Grillot
R
R
Valla
A
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003500:Cyclization; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007094:Imides / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007094:Imides; D013388:Succinimides; D013457:Sulfur Compounds