title: Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens.
abstract: Bioactivity-guided fractionation of the petroleum ether extract of the leaves of Hyptis suaveolens, widely used in Traditional Medicine, has led to the isolation of an abietane-type diterpenoid endoperoxide, 13 alpha-epi-dioxiabiet-8(14)-en-18-ol, displaying high antiplasmodial activity (IC(50) 0.1 microg/ml).
authors.affiliation: Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X0l, Scottsville 3209, South Africa.
authors.forename: J C
authors.initials: JC
authors.lastname: Chukwujekwu
authors.forename: P
authors.initials: P
authors.lastname: Smith
authors.forename: P H
authors.initials: PH
authors.lastname: Coombes
authors.forename: D A
authors.initials: DA
authors.lastname: Mulholland
authors.forename: J
authors.initials: J
authors.lastname: van Staden
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D031331:Hyptis / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D004224:Diterpenes