title: The new trends in theophylline therapy.
abstract: Sustained-release theophylline pellets formulation for once-daily evening administration significantly improved patients compliance and adjusted serum levels profile of the drug. The patients conversion from i.v. to p.o. therapy is one of the most critical steps in the treatment of asthma according to its chronopathophysiological character. In our study we have examined safety and efficiency of this conversion in twelve hospitalised asthmatic patients who were given the new sustained-release theophylline pellets formulation for once-daily evening administration. The lung function parameters (FEV1, VC, RV, and Rt) and serum theophylline concentrations were monitored. So, the values obtained for the last day of i.v. therapy and the fifth day of p.o. therapy were compared. We found that 75% of the patients had no change or improved lung function on the conversion. Our results indicate that this conversion from i.v. to p.o. theophylline therapy is safe and could be efficacious. Also, the maximum theophylline serum levels could safely be predicted by measuring only one serum concentration in p.o. therapy with sustained-release theophylline pellets formulation for once-daily evening administration.
authors.affiliation: Department of Pharmacokinetics, University of Sarajevo, Faculty of Pharmacy, Cekalusa 90, Bosnia and Herzegovina.
authors.forename: Aida
authors.initials: A
authors.lastname: Mehmedagić
authors.forename: Edina
authors.initials: E
authors.lastname: Vranić
authors.forename: Sabira
authors.initials: S
authors.lastname: Hadzović
authors.forename: Milena
authors.initials: M
authors.lastname: Pokrajac
authors.forename: Jela
authors.initials: J
authors.lastname: Milić
authors.forename: Bakir
authors.initials: B
authors.lastname: Mehić
authors.forename: Hasan
authors.initials: H
authors.lastname: Zutić
authors.forename: Abdulah
authors.initials: A
authors.lastname: Konjicija