title: Therapeutic applications of superantibodies.
abstract: Superantibody technology represents a method to enhance the potency and utility of monoclonal antibodies. The blueprint for superantibody technology is taken from rare naturally occurring superantibodies with unique sequence regions, conferring specific biological functions not detected on most antibodies. In superantibody technology, peptides with specific amino acid sequences are crosslinked to antibodies using affinity-site-specific chemistry. Three types of superantibodies have been engineered: dimerizing superantibodies with enhanced effector potency, superantibodies with the ability to penetrate living cells and superantibodies as vaccines with built-in molecular adjuvant. Collectively, superantibody technology generates a new class of antibodies with higher levels of therapeutic potency.
authors.affiliation: Immpheron Inc., Lexington KY 40509, USA.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Michael
authors.initials: M
authors.lastname: Russ
authors.forename: Charles
authors.initials: C
authors.lastname: Morgan
authors.forename: Sybille
authors.initials: S
authors.lastname: Muller
authors.forename: Heinz
authors.initials: H
authors.lastname: Kohler
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use*; D019281:Dimerization; D006801:Humans; D009626:Terminology as Topic
chemical_list: D000911:Antibodies, Monoclonal