title: Survey of the year 2004: literature on applications of isothermal titration calorimetry.
abstract: The market for commercially available isothermal titration calorimeters continues to grow as new applications and methodologies are developed. Concomitantly the number of users (and abusers) increases dramatically, resulting in a steady increase in the number of publications in which isothermal titration calorimetry (ITC) plays a role. In the present review, we will focus on areas where ITC is making a significant contribution and will highlight some interesting applications of the technique. This overview of papers published in 2004 also discusses current issues of interest in the development of ITC as a tool of choice in the determination of the thermodynamics of molecular recognition and interaction.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Abdessamad
authors.initials: A
authors.lastname: Ababou
authors.forename: John E
authors.initials: JE
authors.lastname: Ladbury
mesh_terms: D002151:Calorimetry / Q000295:instrumentation / Q000379:methods*; D018360:Crystallography, X-Ray; D004268:DNA-Binding Proteins / Q000737:chemistry; D015195:Drug Design; D008823:Micelles; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D035181:TATA-Box Binding Protein / Q000737:chemistry; D013816:Thermodynamics; D017186:Titrimetry / Q000295:instrumentation / Q000379:methods
chemical_list: D004268:DNA-Binding Proteins; D008823:Micelles; D035181:TATA-Box Binding Protein