title: Facilitated column selection in pharmaceutical analyses using a simple column classification system.
abstract: In this paper, the performance of a previously developed classification system applied to pharmaceutical chromatographic analyses, is investigated. The separation of seven different drug substances from their respective impurities was studied. The chromatographic procedure for acetylsalicylic acid, clindamycin hydrochloride, buflomedil hydrochloride, chloramphenicol sodium succinate, nimesulide and phenoxymethylpenicillin was performed according to the corresponding European Pharmacopoeia (Ph. Eur.) monograph. The separation of dihydrostreptomycin sulphate was performed according to the literature. It is shown that the column ranking system is a helpful tool in the selection of a suitable column in these analyses.
authors.affiliation: Katholieke Universiteit Leuven, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, Van Evenstraat 4, B-3000 Leuven, Belgium.
authors.forename: Dóra
authors.initials: D
authors.lastname: Visky
authors.forename: Erik
authors.initials: E
authors.lastname: Haghedooren
authors.forename: Pieter
authors.initials: P
authors.lastname: Dehouck
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kovács
authors.forename: Kristof
authors.initials: K
authors.lastname: Kóczián
authors.forename: Béla
authors.initials: B
authors.lastname: Noszál
authors.forename: Jos
authors.initials: J
authors.lastname: Hoogmartens
authors.forename: Erwin
authors.initials: E
authors.lastname: Adams
mesh_terms: D001241:Aspirin / Q000302:isolation & purification; D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000302:isolation & purification; D002853:Chromatography, Liquid / Q000295:instrumentation* / Q000379:methods; D002981:Clindamycin / Q000302:isolation & purification; D004096:Dihydrostreptomycin Sulfate / Q000302:isolation & purification; D010404:Penicillin V / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D011759:Pyrrolidines / Q000302:isolation & purification; D012680:Sensitivity and Specificity; D013449:Sulfonamides / Q000302:isolation & purification
chemical_list: D004364:Pharmaceutical Preparations; D011759:Pyrrolidines; D013449:Sulfonamides; D002981:Clindamycin; D002701:Chloramphenicol; D001241:Aspirin; D004096:Dihydrostreptomycin Sulfate; C012655:nimesulide; C010651:buflomedil; D010404:Penicillin V; C026016:chloramphenicol succinate