An efficient synthesis of risperidone via stille reaction: antipsychotic, 5-HT2, and dopamine-D2-antagonist.
Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.
Kim
Dong-Myung
DM
PDT Bio Co. Ltd., Kyung Hee University, Seoul 130-701, Korea.
Kang
Min-Seok
MS
Kim
Jeong Sook
JS
Jeong
Jin-Hyun
JH
D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D018492:Dopamine Antagonists / Q000138:chemical synthesis*; D065127:Dopamine D2 Receptor Antagonists; D018967:Risperidone / Q000138:chemical synthesis*; D058830:Serotonin 5-HT2 Receptor Antagonists; D012702:Serotonin Antagonists / Q000138:chemical synthesis*
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D012702:Serotonin Antagonists; D018967:Risperidone