Association between genital tract cytomegalovirus infection and bacterial vaginosis.
Women with sexually transmitted diseases (STDs) and bacterial vaginosis (BV) have increased rates of cytomegalovirus (CMV) seroprevalence and CMV seroconversion. To characterize the association between genital tract CMV infection and BV, vaginal wash specimens from 52 women attending an STD clinic were analyzed. Significantly more women with BV shed CMV in the lower genital tract than did women without BV. In addition, most of the women who were shedding CMV were infected with >1 virus strain. These results suggest that local CMV replication and infection with multiple CMV strains is facilitated by the presence of BV.
Ross
Shannon A
SA
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA. sross@peds.uab.edu
Novak
Zdenek
Z
Ashrith
Guha
G
Rivera
Lisa B
LB
Britt
William J
WJ
Hedges
Spencer
S
Schwebke
Jane R
JR
Boppana
And Suresh
AS
D000328:Adult; D003587:Cytomegalovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D014621:Vagina / Q000821:virology*; D016585:Vaginosis, Bacterial / Q000150:complications* / Q000453:epidemiology; D014759:Viral Envelope Proteins / Q000235:genetics; D017201:Virus Shedding
D004279:DNA, Viral; D014759:Viral Envelope Proteins; C417883:glycoprotein N, Human cytomegalovirus