[Effect of high-iodine intake on MBP mRNA expression in cerebrum of filial mice and selenium intervention].
OBJECTIVE
To study the effect of selenium supplementation on myelin basic protein (MBP) mRNA expression in cerebrum of high-iodine intake filial mice.


METHODS
135 weanling female Balb/C mice were assigned into 3 groups and given drinking water including different doses of iodine and selenium. Normal control (NC, tap water), high iodine intake group (HI, 3.0 mg/L I of drinking water), high iodine intake and selenium supplementation group I (HI + Se, 3.0 mg/L I + 0.5 mg/L Se of drinking water). All the male and female mice were mated after 4 months later, related indicators of filial mice on 14 day were determined.


RESULTS
In filial mice, compared with NC group, serum TT4 decreased significantly in HI groups, TT3 also decreased, and mRNA expression of MBP in cerebrum was down-regulated 27%. The selenium suppleme ntation groups inhibited the decrease of TT4 and TT3, up regulated the m RNA expression of MBP in cerebrum.


CONCLUSIONS
High-iodine Intake can decrease thyroxine of filial mice, which maybe is the reason for down-regulated m RNA expression of MBP in cerebrum, and selenium can exert some intervention by thyroxine, but need to verify more.
Hou
Xiao-Hui
XH
Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yang
Xue-Feng
XF
Sun
Xiu-Fa
XF
Guo
Huai-Lan
HL
Xu
Jian
J
Chen
Xiaoyi
X
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D007455:Iodine / Q000008:administration & dosage* / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D004676:Myelin Basic Protein / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012643:Selenium / Q000494:pharmacology*; D014886:Weaning
D004676:Myelin Basic Protein; D012333:RNA, Messenger; D007455:Iodine; D012643:Selenium