title: Human trophoblast function during the implantation process.
abstract: The implantation process involves complex and synchronized molecular and cellular events between the uterus and the implanting embryo. These events are regulated by paracrine and autocrine factors. Trophoblast invasion and migration through the uterine wall is mediated by molecular and cellular interactions, controlled by the trophoblast and the maternal microenvironment. This review is focused on the molecular constituents of the human trophoblast, their actions and interactions, including interrelations with the uterine endometrium.
authors.affiliation: Department of Obstetrics and Gynecology, Ha'Emek Medical Center, 18101, Afula, Israel. elsebeth@tx.technion.ac.il
authors.forename: Elsebeth
authors.initials: E
authors.lastname: Staun-Ram
authors.forename: Eliezer
authors.initials: E
authors.lastname: Shalev
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology*; D004815:Epidermal Growth Factor / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005260:Female; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000502:physiology; D016023:Integrins / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D053605:Leukemia Inhibitory Factor; D020782:Matrix Metalloproteinases / Q000502:physiology; D018396:Mucin-1 / Q000502:physiology; D011374:Progesterone / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D012697:Serine Endopeptidases / Q000502:physiology; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014327:Trophoblasts / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D006063:Chorionic Gonadotropin; D016326:Extracellular Matrix Proteins; C587883:HBEGF protein, human; D066257:Heparin-binding EGF-like Growth Factor; C032231:IGFBP1 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D007375:Interleukin-1; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D018396:Mucin-1; D011453:Prostaglandins; D019714:Tissue Inhibitor of Metalloproteinases; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D011374:Progesterone; D004815:Epidermal Growth Factor; D003346:Corticotropin-Releasing Hormone; D012697:Serine Endopeptidases; D020782:Matrix Metalloproteinases