title: HIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide.
abstract: We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts.
authors.affiliation: Sección de Inmunología, Hospital Donostia, San Sebastian, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Saez
authors.forename: Pilar
authors.initials: P
authors.lastname: Echaniz
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: de Juan
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Iribarren
authors.forename: Emilio
authors.initials: E
authors.lastname: Cuadrado
mesh_terms: D016022:Case-Control Studies; D018450:Disease Progression; D005500:Follow-Up Studies; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*
chemical_list: D009838:Oligodeoxyribonucleotides; D007371:Interferon-gamma