title: Notch signaling is an important regulator of type 2 immunity.
abstract: Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4+ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.
authors.affiliation: Department of Pathology and Laboratory Medicine, School of Veterinary Medicine, Philadelphia, PA 19104, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Tu
authors.forename: Terry C
authors.initials: TC
authors.lastname: Fang
authors.forename: David
authors.initials: D
authors.lastname: Artis
authors.forename: Olga
authors.initials: O
authors.lastname: Shestova
authors.forename: Seth E
authors.initials: SE
authors.lastname: Pross
authors.forename: Ivan
authors.initials: I
authors.lastname: Maillard
authors.forename: Warren S
authors.initials: WS
authors.lastname: Pear
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D017931:DNA Primers; D005434:Flow Cytometry; D049452:Green Fluorescent Proteins; D007111:Immunity, Cellular / Q000276:immunology*; D007891:Leishmania / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D051880:Receptors, Notch / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D018418:Th2 Cells / Q000378:metabolism*; D014258:Trichuris / Q000276:immunology
chemical_list: D017931:DNA Primers; D051880:Receptors, Notch; D049452:Green Fluorescent Proteins