title: Heparin-induced thrombocytopenia: clinical presentations and therapeutic management.
abstract: With increasing indications for heparin usage, an understanding of heparin-induced thrombocytopenia (HIT) as a complication of heparin therapy is more essential than ever. Complications of HIT can result in significant morbidity and mortality. We review the clinical presentations of HIT, laboratory and diagnostic workup, and treatment agents available or being evaluated.
authors.affiliation: Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA. larne001@mc.duke.edu
authors.forename: Zoë L
authors.initials: ZL
authors.lastname: Larned
authors.forename: Susan I
authors.initials: SI
authors.lastname: O'Shea
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Ortel
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D015897:Comorbidity; D019468:Disease Management; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin