Chronic bacterial-viral vasculitis as manifestation of systemic inflammatory response syndrome in females.
Study involved 52 women (mean age 43+/-1,3) without any evidence of CHD, suffering from dull or acute prolonged non-anginal chest pain, with undergoing chronic bacterial-viral infection--Chlamydia pneumonia in combination with HSV-I, CMV and/or EBV. 30--patients serum-positive to plasma markers (IgG antibodies) of previous infection were enclosed in group I, 22--with plasma consumption of IgA+IgG antibody complex demonstrating re-infection/reactivation phase of disease--in group II and 20 healthy serum-negative females (median age 47+/-2,8 years)--controls (group III). The intergroup analysis revealed the complex of disturbances in some plasma parameters of II group patients, namely significant elevation of CRP, F and LPO activity vs. I and III group data, along with reduced parameters of immune status in both groups of infected persons. The patients with mixed infections showed the high frequency of specific re-polarization phase abnormalities, cardiac rhythm and conduction disturbances. These changes together with intimate-medial wall injuries of inflammatory origin disclosed by DS technique enables us to suggest that in women with previous chronic untreated or insufficiently treated infection, in cases of their overload activity, recurrent or super-infection may provide deep immunosuppressive conditions leading to farther cardio-vascular abnormalities.
Kvantaliani
T
T
Tsinamdzgvrishvili Institute of Cardiology, Research Laboratory 'Test-Physician's House', Center of Angiology and Vascular Surgery, Tbilisi.
Tsiklauri
P
P
Pargalava
N
N
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008875:Middle Aged; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000276:immunology; D014657:Vasculitis / Q000175:diagnosis* / Q000382:microbiology* / Q000821:virology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M