Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials.
In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.
Chen
Shengfu
S
Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
Zheng
Jie
J
Li
Lingyan
L
Jiang
Shaoyi
S
D000327:Adsorption; D000818:Animals; D002417:Cattle; D006023:Glycoproteins / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D018625:Microscopy, Atomic Force / Q000379:methods; D015394:Molecular Structure; D010316:Particle Size; D010767:Phosphorylcholine / Q000138:chemical synthesis / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D055672:Static Electricity; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013499:Surface Properties; D013997:Time Factors
D006023:Glycoproteins; D013438:Sulfhydryl Compounds; D010767:Phosphorylcholine; D012710:Serum Albumin, Bovine; D006046:Gold