title: Prognostic value of tissue inhibitor of metalloproteinase-1 for cardiovascular death among patients with cardiovascular disease: results from the AtheroGene study.
abstract: OBJECTIVE
  Metalloproteinases are proteolytic enzymes, which decompose the extracellular matrix, influence cardiac remodelling, and are inhibited by tissue inhibitor of metalloproteinases (TIMPs). Little is known about the prognostic impact of the TIMP-1/matrix metalloproteinase complex in patients with future cardiovascular death.
  
  
  RESULTS
  In 1979 patients with suspected coronary artery disease (CAD), TIMP-1 has been determined at baseline. Among 1945 (98.4%) patients with a mean follow-up period of 2.6+/-1.2 years, 75 patients died because of cardiovascular causes. Mean concentrations of TIMP-1 were higher among patients who experienced a fatal cardiovascular event than among those who did not (820 vs. 692 ng/mL; P<0.001). Age and sex adjusted hazard ratio of future cardiovascular death associated with one standard deviation of TIMP-1 level, was 1.37 (95% CI: 1.17-1.61; P<0.001). The hazard ratio remained nearly identical after adjustment for clinical and therapeutic confounders. B-type natriuretic peptide (2.75, 95% CI: 1.94-3.89; P<0.001), C-reactive protein (1.79, 95% CI: 1.43-2.24; P<0.001), and TIMP-1 (1.30, 95% CI: 1.07-1.58; P=0.008) were independently associated with future cardiovascular death.
  
  
  CONCLUSIONS
  In patients with CAD, TIMP-1 proves as an independent predictor for future cardiovascular death.
authors.affiliation: Department of Medicine II, Johannes Gutenberg-University, Langenbeckstrasse 1, 55101 Mainz, Germany. edithlubos@gmx.de
authors.forename: Edith
authors.initials: E
authors.lastname: Lubos
authors.forename: Renate
authors.initials: R
authors.lastname: Schnabel
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Rupprecht
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Messow
authors.forename: Susanne
authors.initials: S
authors.lastname: Prigge
authors.forename: François
authors.initials: F
authors.lastname: Cambien
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
authors.forename: Thomas
authors.initials: T
authors.lastname: Münzel
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000201:enzymology* / Q000401:mortality; D003324:Coronary Artery Disease / Q000201:enzymology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D019715:Tissue Inhibitor of Metalloproteinase-1