Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.
Stable isotope labeled 3-acetyldeoxynivalenol (3-AcDON) was synthesized in excellent yield from deoxynivalenol as starting material. This is the first synthesis of a stable isotope labeled type-B trichothecene suitable as internal standard for HPLC-MS/MS or GC-MS analysis of trichothecene mycotoxins. The isotopic purity of the 3-d(3)-AcDON was determined to be 94.9%.
Bretz
Michael
M
Institut für Lebensmittelchemie, Westfälische Wilhelms-Universität Münster, Correnstrasse 45, 48149 Münster, Germany.
Beyer
Marita
M
Cramer
Benedikt
B
Humpf
Hans-Ulrich
HU
D002851:Chromatography, High Pressure Liquid / Q000592:standards; D008401:Gas Chromatography-Mass Spectrometry / Q000592:standards; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry / Q000592:standards; D015394:Molecular Structure; D009183:Mycotoxins / Q000032:analysis; D014255:Trichothecenes / Q000032:analysis / Q000138:chemical synthesis* / Q000737:chemistry
D009183:Mycotoxins; D014255:Trichothecenes; C043247:3-acetyldeoxynivalenol; C007262:deoxynivalenol