Cyclopeptide alkaloids from Scutia buxifolia Reiss and their antimicrobial activity.
The present study reports a cyclopeptide alkaloid, scutianine M, isolated from the methanolic root bark extract of Scutia buxifolia Reiss (Rhamnaceae) along with six known compounds, scutianines-B, -C, -D, -E, -F, and scutianene D. Its structure was established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. As part of a study of the bioactive compounds of medicinal plants from southern Brazil, we also compared the antimicrobial activity of the isolated compounds towards Gram (+), Gram (-) bacteria, and yeasts.
Morel
Ademir F
AF
Departamento de Química (NPPN), Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. afmorel@base.ufsm.br
Maldaner
Graciela
G
Ilha
Vinicius
V
Missau
Fabiana
F
Silva
Ubiratan F
UF
Dalcol
Ionara I
II
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D027823:Rhamnaceae / Q000737:chemistry*
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic