Uncoupling proteins: targets of endocrine disruptors?
The roles of uncoupling proteins (UCPs) are discussed. Particular attention has been paid to the roles of UCP2 to UCP5 as agents mediating thermogenesis, and to the concept of limited or "mild" uncoupling as a means of reducing oxidative stress. The role of the endocrine system, thyroid hormones and catecholamines, in regulating expression of UCPs is also discussed.
Pawade
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Department of Medicine, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, UK.
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Kwok
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Ramsden
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D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology; D052244:Endocrine Disruptors / Q000494:pharmacology*; D006801:Humans; D007473:Ion Channels; D008565:Membrane Proteins / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D022722:Thermogenesis / Q000502:physiology*; D013963:Thyroid Hormones / Q000502:physiology; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D002395:Catecholamines; D052244:Endocrine Disruptors; D007473:Ion Channels; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D013963:Thyroid Hormones; C000604389:UCP2 protein, human; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3; D000255:Adenosine Triphosphate