title: Caucanolides A-F, unusual antiplasmodial constituents from a colombian collection of the gorgonian coral Pseudopterogorgia bipinnata.
abstract: Six new diterpenoids, caucanolides A-F (1-6), have been isolated from extracts of the gorgonian octocoral Pseudopterogorgia bipinnata collected near the Colombian Southwestern Caribbean Sea. The structures of 1-6 were elucidated by comprehensive analysis of spectroscopic data. The caucanolides showed in vitro antiplasmodial activity against the malaria parasite, Plasmodium falciparum. In addition to possessing structures based on novel carbon skeletons, one of these metabolites, caucanolide B (2), constitutes the only example from nature of a secondary metabolite possessing the N(1),N(1)-dimethyl-N(2)-acylformamidine functionality.
authors.affiliation: Department of Chemistry, University of Puerto Rico, P. O. Box 23346, U.P.R. Station, San Juan, Puerto Rico 00931-3346.
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Ospina
authors.forename: Abimael D
authors.initials: AD
authors.lastname: Rodríguez
authors.forename: Juan A
authors.initials: JA
authors.lastname: Sánchez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barria
authors.forename: Todd L
authors.initials: TL
authors.lastname: Capson
authors.forename: Alejandro M S
authors.initials: AM
authors.lastname: Mayer
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017691:Caribbean Region; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D004224:Diterpenes