Posaconazole therapy for systemic coccidioidomycosis in a chimpanzee (Pan troglodytes): a case report.
Systemic coccidioidomycosis was diagnosed in a 4-year-old male chimpanzee (Pan troglodytes) with ascites and failure to thrive. Physical examination, laboratory and radiological studies, and exploratory laparotomy showed signs of systemic fungal infection that included penetration into the central nervous system (CNS). Serum and cerebrospinal fluid (CSF) titres, along with ascites cytology findings, confirmed the presence of Coccidioides immitis. However, the organism could not be cultured from the CSF. Treatment with fluconazole 10 mg kg(-1) daily for 6 months was not associated with clinical improvement. Subsequent treatment with posaconazole 50 mg kg(-1) daily for approximately 24 months resulted in negative serum titres and improved clinical status. Illness not directly related to the C. immitis infection caused the chimpanzee's deterioration and eventual killing. Histological examination performed during necropsy provided no evidence of coccidioidomycosis; however, a positive C. immitis serum antibody titre was noted. The successful suppression of coccidioidomycosis observed in this chimpanzee suggests that posaconazole may have a role in the treatment of CNS infections caused by susceptible fungi.
Herrin
Kimberly Vinette
KV
Miranda
Abraham
A
Loebenberg
David
D
D000818:Animals; D000908:Antibodies, Fungal / Q000097:blood; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018420:Ape Diseases / Q000188:drug therapy* / Q000382:microbiology; D001769:Blood / Q000382:microbiology; D020314:Central Nervous System Fungal Infections / Q000382:microbiology / Q000662:veterinary; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003045:Coccidioides / Q000187:drug effects / Q000302:isolation & purification*; D003047:Coccidioidomycosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D010535:Laparoscopy; D008297:Male; D002679:Pan troglodytes; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*
D000908:Antibodies, Fungal; D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D015725:Fluconazole