Reduction in dietary calcium/phosphorus ratio reduces bone mass and strength in ovariectomized rats enhancing bone turnover.
To clarify the effects of the dietary calcium (Ca)/phosphorus (P) ratio on bone mineralization under the condition of estrogen deficiency, Wistar strain female rats were ovariectomized (OVX) at 12 weeks old. At 16 weeks old, the rats were divided into three dietary groups fed varying levels of P containing 0.5% Ca: 0.25% P, Ca/P = 2; 0.5% P, Ca/P = 1; and 1.0% P, Ca/P = 0.5 respectively. This study indicates that the reduction of the dietary Ca/P ratio impairs trabecular bone turnover accompanying the acceleration of bone formation in OVX rats.
Koshihara
Moyuru
M
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Sakuragaoka, Japan.
Masuyama
Ritsuko
R
Uehara
Mariko
M
Suzuki
Kazuharu
K
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects*; D002113:Calcification, Physiologic; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D010012:Osteogenesis; D010052:Ovariectomy; D016226:Phosphorus, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002136:Calcium, Dietary; D004967:Estrogens; D016226:Phosphorus, Dietary