Blockade of beta-adrenoceptors and muscarinic cholinergic receptors modulates effect on nitric oxide on heart rate in rats.
Nitroglycerine in doses of 0.4-1.0 mg/kg decreased the heart rate in rats, which was associated with inhibition of adrenergic influences realized via beta-adrenoceptors. The negative chronotropic effect of sodium nitroprusside in a dose of 1 mg/kg was more significant compared to that of nitroglycerine (by 2-3 times). It was associated with inhibition of adrenergic and stimulation of cholinergic influences mediated via beta-adrenoceptors and muscarinic cholinergic receptors, respectively. During blockade of beta-adrenoceptors and muscarinic cholinergic receptors, sodium nitroprusside increased the time of atrioventricular conduction. These data indicate that function of myocytes in the heart conduction system of rats depends on the PQ interval.
Nasyrova
A G
AG
Department of Normal Physiology, Kazan State Medical University.
Nigmatullina
R R
RR
Latfullin
I A
IA
Rakhmatullina
F F
FF
D000319:Adrenergic beta-Antagonists / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000378:metabolism / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000378:metabolism / Q000494:pharmacology*; D005996:Nitroglycerin / Q000378:metabolism / Q000494:pharmacology*; D009599:Nitroprusside / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D018727:Muscarinic Antagonists; D020030:Nitric Oxide Donors; D009599:Nitroprusside; D005996:Nitroglycerin