Conversion of a carboxylesterase into a triacylglycerol lipase by a random mutation.
Reyes-Duarte
Dolores
D
Institute of Catalysis, CSIC, Cantoblanco, 28049 Madrid, Spain.
Polaina
Julio
J
López-Cortés
Nieves
N
Alcalde
Miguel
M
Plou
Francisco J
FJ
Elborough
Kieran
K
Ballesteros
Antonio
A
Timmis
Kenneth N
KN
Golyshin
Peter N
PN
Ferrer
Manuel
M
D043182:Carboxylesterase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000235:genetics*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000235:genetics*; D016296:Mutagenesis; D009154:Mutation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D043182:Carboxylesterase; D008049:Lipase