Micromachined devices: the impact of controlled geometry from cell-targeting to bioavailability.
Advances in microelectomechanical systems (MEMS) have allowed the microfabrication of polymeric substrates and the development of a novel class of controlled delivery devices. These vehicles have specifically tailored three-dimensional physical and chemical features which, together, provide the capacity to target cells, promote unidirectional controlled release, and enhance permeation across the intestinal epithelial barrier. Examining the biological response at the microdevice biointerface may provide insight into the benefits of customized surface chemistry and structure in terms of complex drug delivery vehicle design. Therefore, the aim of this work was to determine the interfacial effects of selective surface chemistry and architecture of tomato lectin (TL)-modified poly(methyl methacrylate) (PMMA) drug delivery microdevices on the Caco-2 cell line, a model of the gastrointestinal tract.
Tao
Sarah L
SL
Department of Biomedical Engineering, Boston University, MA 02215, USA.
Desai
Tejal A
TA
D001682:Biological Availability; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D004553:Electric Conductivity; D006801:Humans; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D008928:Mitochondria / Q000187:drug effects; D036103:Nanotechnology; D010637:Phenolsulfonphthalein; D037121:Plant Lectins / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D012666:Semiconductors; D013499:Surface Properties; D014343:Trypan Blue
D007202:Indicators and Reagents; D037121:Plant Lectins; D011108:Polymers; C034981:tomato lectin; D019904:Polymethyl Methacrylate; D014343:Trypan Blue; D010637:Phenolsulfonphthalein