Topical delivery of retinyl ascorbate co-drug: 6. Determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes.
The maximum effective dose of retinyl ascorbate and its potential therapeutic benefits against induced oxidative damage were assessed in vitro using cultured human epidermal keratinocytes. RA-AsA exhibited toxic effects at concentrations >6 microM. The findings indicate to the potency of RA-AsA as free radical scavenger and cell proliferation regulator.
Abdulmajed
K
K
Welsh School of Pharmacy, Cardiff University, UK.
McGuigan
C
C
Heard
C M
CM
D000287:Administration, Topical; D000975:Antioxidants / Q000008:administration & dosage* / Q000633:toxicity*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D002452:Cell Count; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D012176:Retinoids / Q000008:administration & dosage* / Q000633:toxicity*; D000084562:Retinyl Esters; D013056:Spectrophotometry, Ultraviolet
D000975:Antioxidants; D016166:Free Radical Scavengers; D012176:Retinoids; D000084562:Retinyl Esters; C504062:retinyl ascorbate; D001205:Ascorbic Acid