title: Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test.
abstract: Four Trypanosoma (T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kénédougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation infectivity test (DIIT). All field stocks from Kénédougou were resistant to 1.0 mg/kg bw isometamidium in the SMT. Fourteen stocks (87.5%) also proved to be refractory to 10 mg/kg bw. Testing with the DIIT confirmed the results of the SMT. By comparison to reference clones, all the Kénédougou populations expressed high levels of resistance to isometamidium.
authors.affiliation: Institute for Parasitoloy and International Animal Health, Freie Universität Berlin, Königsweg 67, D-14163 Berlin, Germany.
authors.forename: Tanja Nikola
authors.initials: TN
authors.lastname: Knoppe
authors.forename: Burkhard
authors.initials: B
authors.lastname: Bauer
authors.forename: John J
authors.initials: JJ
authors.lastname: McDermott
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Peregrine
authors.forename: Dieter
authors.initials: D
authors.lastname: Mehlitz
authors.forename: Peter-Henning
authors.initials: PH
authors.lastname: Clausen
mesh_terms: D000818:Animals; D002050:Burkina Faso; D002417:Cattle; D004351:Drug Resistance; D051379:Mice; D051189:Murinae; D010617:Phenanthridines / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014348:Trypanosoma congolense / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity*; D014353:Trypanosomiasis, African / Q000469:parasitology; D014354:Trypanosomiasis, Bovine / Q000469:parasitology
chemical_list: D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride