title: [The biotransformation of kaempferitrin by human intestinal flora].
abstract: OBJECTIVE
  To study the biotransformation of kaempferitrin, a major chemical principle of the fruits of Siraitia grosvenori (Swingle) C. Jeffery, with human intestinal flora.
  
  
  METHODS
  The kaempferitrin was incubated with human intestinal flora. The biotransformation products were isolated and purified by chromatographic methods and the structures were determined by spectroscopic techniques.
  
  
  RESULTS
  Kaempferitrin was converted into kaempferol 3-O-alpha-L-rhamnoside (afzelin, I) , kaempferol 7-O-alpha-L-rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora. rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora.
  
  
  CONCLUSIONS
  The structure of kaempferitrin can be biotransformatedly converted by human intestinal flora.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. xwyang@bjmu.edu.cn
authors.forename: Xiu-wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Jian-ye
authors.initials: JY
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Wei-qing
authors.initials: WQ
authors.lastname: Zhang
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D044949:Kaempferols / Q000302:isolation & purification / Q000378:metabolism / Q000493:pharmacokinetics*; D008362:Mannosides / Q000378:metabolism; D029775:Momordica / Q000737:chemistry; D010226:Parabens / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D044945:Proanthocyanidins / Q000378:metabolism
chemical_list: D044949:Kaempferols; D008362:Mannosides; D010226:Parabens; D044945:Proanthocyanidins; C477954:afzelin; C006552:kaempferol; C038193:4-hydroxybenzoic acid; C042728:lespenefril