title: Detection of an mRNA polymorphism by differential display.
abstract: Differential display technology was utilized to compare programs of gene expression in primary cultures of human skin fibroblasts from normal volunteers and patients diagnosed with melancholic depression. Polymorphic transcripts of a single gene differing by one tandem repeat sequence of four nucleotides (TGAT) in the 3' noncoding region were detected.
authors.affiliation: Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Liang
authors.forename: S Paul
authors.initials: SP
authors.lastname: Rossby
authors.forename: Peng
authors.initials: P
authors.lastname: Liang
authors.forename: Richard C
authors.initials: RC
authors.lastname: Shelton
authors.forename: D Hal
authors.initials: DH
authors.lastname: Manier
authors.forename: Amitabha
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: Fridolin
authors.initials: F
authors.lastname: Sulser
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry; D018076:DNA, Complementary / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012313:RNA / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012867:Skin / Q000166:cytology; D014158:Transcription, Genetic
chemical_list: D018076:DNA, Complementary; D009711:Nucleotides; D012333:RNA, Messenger; D012313:RNA; D004247:DNA