A new fungicide produced by a Streptomyces sp. GAAS7310.
Directed bioassay guided fraction led to a new macrodiolide antimycin A(17) (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of 1D and 2D NMR data and comparison with the known antimycin A(1a).
Chen
Guangying
G
Department of Chemistry, Hainan Normal University, Haikou 571158, People's Republic of China.
Lin
Birun
B
Lin
Yongcheng
Y
Xie
Fengchun
F
Lu
Wen
W
Fong
Wang-Fun
WF
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000968:Antimycin A / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020231:Colletotrichum / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D012233:Rhizopus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
D000935:Antifungal Agents; D000968:Antimycin A