title: Common variants of LRRK2 are not associated with sporadic Parkinson's disease.
abstract: Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8). The Gly2019Ser mutation appears to be common in different populations. To investigate whether this novel gene influences the non-Mendelian sporadic form of Parkinson's disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a set of 340 Parkinson's disease patients and 680 matched control subjects from Germany. No association could be demonstrated. We have therefore no evidence for the existence of a common variant in LRRK2 that has a strong influence on Parkinson's disease risk.
authors.affiliation: Institute of Human Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany.
authors.forename: Saskia
authors.initials: S
authors.lastname: Biskup
authors.forename: Jakob C
authors.initials: JC
authors.lastname: Mueller
authors.forename: Manu
authors.initials: M
authors.lastname: Sharma
authors.forename: Peter
authors.initials: P
authors.lastname: Lichtner
authors.forename: Alexander
authors.initials: A
authors.lastname: Zimprich
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Ullrich
authors.initials: U
authors.lastname: Wüllner
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
mesh_terms: D017668:Age of Onset; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D012307:Risk Factors
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases