Ortho-hydroxylation of benzoic acids with hydrogen peroxide at a non-heme iron center.
The iron-assisted hydroxylation of benzoic acid to salicylic acid by 1/H2O2 has been achieved in good yield under mild conditions (where is [Fe(II)(BPMEN)(CH3CN)2](ClO4)2 and BPMEN =N,N'-dimethyl-N,N'-bis(2-pyridylmethyl)ethane-1,2-diamine); the product of this reaction is a novel mononuclear iron(III) complex with a chelating salicylate.
Taktak
Sonia
S
Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155, USA.
Flook
Margaret
M
Foxman
Bruce M
BM
Que
Lawrence
L
Rybak-Akimova
Elena V
EV
D001565:Benzoates / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D006900:Hydroxylation; D008958:Models, Molecular; D015394:Molecular Structure; D019159:Nonheme Iron Proteins / Q000737:chemistry*
D001565:Benzoates; D019159:Nonheme Iron Proteins; D006861:Hydrogen Peroxide