title: Gadolinium-enhanced magnetic resonance angiography, colour duplex and digital subtraction angiography of the lower limb arteries from the aorta to the tibio-peroneal trunk in patients with intermittent claudication.
abstract: OBJECTIVE
  To evaluate the sensitivity, specificity, positive and negative predictive value of contrast-enhanced (gadolinium) magnetic resonance imaging (CE-MRA) and colour duplex ultrasound (CDU) of lower limb arteries.
  
  
  METHODS
  Prospective, single centre study.
  
  
  METHODS
  A consecutive series of 58 patients with intermittent claudication (IC) were examined with CE-MRA and CDU from the infrarenal aorta to the tibio-peroneal trunk with digital subtraction angiography (DSA) as reference. The arterial tree was divided into 15 segments, pooled into three regions; suprainguinal, thigh and knee. Sensitivity, specificity, positive and negative predictive values for significant obstructions were calculated. Cohen Kappa statistics was used to establish agreement between the three methods.
  
  
  RESULTS
  The sensitivity (specificity in parentheses) for significant obstructions in the suprainguinal region were 96% (94%) for CE-MRA and 91% (96%) for CDU, in the thigh region 92% (95%) for CE-MRA and 76% (99%) for CDU, and in the knee region 93% (96%) for CE-MRA and 33% (98%) for CDU. CDU failed to visualize 10% of suprainguinal, 2% of thigh and 13% of knee-region arterial segments.
  
  
  CONCLUSIONS
  Both CE-MRA and CDU are good alternatives to DSA in the suprainguinal- and thigh-region. In the knee region only CE-MRA can be relied upon as an alternative to DSA. Imaging by CDU is not suited to situations were evaluation of runoff vessels is important.
authors.affiliation: Department of Radiology, Aker University Hospital, Oslo, Norway. eyvind.gjonnass@ulleval.no
authors.forename: E
authors.initials: E
authors.lastname: Gjønnaess
authors.forename: B
authors.initials: B
authors.lastname: Morken
authors.forename: G
authors.initials: G
authors.lastname: Sandbaek
authors.forename: E
authors.initials: E
authors.lastname: Stranden
authors.forename: C-E
authors.initials: CE
authors.lastname: Slagsvold
authors.forename: J J
authors.initials: JJ
authors.lastname: Jørgensen
authors.forename: M
authors.initials: M
authors.lastname: Nylaende
authors.forename: M
authors.initials: M
authors.lastname: Abdelnoor
authors.forename: R
authors.initials: R
authors.lastname: Dullerud
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction / Q000379:methods*; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D007383:Intermittent Claudication / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016909:Tibial Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D018615:Ultrasonography, Doppler, Color / Q000379:methods*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA