title: [Epithelial cell proliferation in nasal polyps].
abstract: The mechanism stimulating the growth of nasal polyps remains unclear. The fact that nasal polyps formation is connected with increase of the epithelial surface suggests that the dysregulation of epithelial cell proliferation takes part in their pathogenesis. Furthermore, macroscopically nonsuspected nasal polyp, usually benign tissue lesion, occasionally may be misdiagnosed such as neoplasm. Only a few studies have undertaken the subject of cell proliferation in nonneoplastic respiratory epithelium. We examined 30 nasal polyps specimens by immunohistochemistry to recognize the expression of nuclear antigen present in proliferating cells, using rabbit anti-human Ki-67 antigen. Our study revealed significantly higher Ki-67 index in nasal polyps than in nasal mucosa (p < 0.005, tab.I). Based on this findings it seems that increased epithelial cell proliferation and chronic inflammation generate the lesion of the nasal mucosa leading to nasal polyps formation.
authors.affiliation: Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej AM im. prof. Feliksa Skubiszewskiego w Lublinie.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Tryka
authors.forename: Danuta
authors.initials: D
authors.lastname: Skomra
authors.forename: Janusz
authors.initials: J
authors.lastname: Klatka
authors.forename: Regina
authors.initials: R
authors.lastname: Gieroba
authors.forename: Witold
authors.initials: W
authors.lastname: Olszański
mesh_terms: D049109:Cell Proliferation; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D009298:Nasal Polyps / Q000473:pathology*
chemical_list: D019394:Ki-67 Antigen