title: Teenage asthma after severe infantile bronchiolitis or pneumonia.
abstract: OBJECTIVE
  The purpose of the study was to evaluate asthma at >13 y of age in children with infantile bronchiolitis or pneumonia.
  
  
  METHODS
  In 1981-1982, 127 children at <2 y of age were hospitalized for bronchiolitis (n = 81) or pneumonia (n = 46). Respiratory syncytial virus (RSV) infection, eosinophilia and markers of atopy were assessed and recorded on admission. At a median age of 14.9 y, atopic and asthmatic symptoms were screened by a written questionnaire in 98/127 (77%) study subjects.
  
  
  RESULTS
  Asthma was present, according to two definitions, in 14% to 23% in the original bronchiolitis and in 12% to 15% in the original pneumonia group. The figures were 8% to 17% in the RSV infection and 16% to 23% in the non-RSV infection group. Early asthma-predictive factors were repeated wheezing, atopic dermatitis and elevated blood eosinophils. All but one of the teenage asthmatics had allergic rhinitis.
  
  
  CONCLUSIONS
  An increased risk for asthma persists until the teenage period after bronchiolitis and pneumonia in infancy. Both early and later atopy were significant risk factors. The present study was unable to demonstrate the association between early RSV infection and teenage asthma.
authors.affiliation: Department of Paediatrics, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Mari
authors.initials: M
authors.lastname: Hyvärinen
authors.forename: Eija
authors.initials: E
authors.lastname: Piippo-Savolainen
authors.forename: Kaj
authors.initials: K
authors.lastname: Korhonen
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology*; D001990:Bronchiolitis, Viral / Q000150:complications* / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016001:Confidence Intervals; D004198:Disease Susceptibility / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016017:Odds Ratio; D011014:Pneumonia / Q000150:complications* / Q000175:diagnosis; D015995:Prevalence; D011336:Probability; D011379:Prognosis; D012129:Respiratory Function Tests; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index; D017678:Sex Distribution