title: Long-term follow-up after invasive approach of coronary artery disease in daily practice.
abstract: BACKGROUND
  To assess long-term survival in unselected patients with coronary artery disease in who an invasive approach is considered.
  
  
  METHODS
  All patients with significant coronary artery disease who were presented for coronary revascularisation to two tertiary centres in 1992 were included. Follow-up data were collected in September 2002. Multivariate Cox' proportional-hazards regression analysis was applied to assess the independent relation between variables and 10-year survival.
  
  
  RESULTS
  A total of 877 patients were included in this analysis. Mean age was 62 and the most common clinical diagnosis was chronic stable angina (60%). Diabetes was present in 12% of the patients. During the follow-up period, 233 patients (27%) died. Predictors of long-term survival were increasing age, diabetes, peripheral vascular disease and a decreased left ventricular function. Compared to medical treated patients, those treated with revascularisation (either by PCI or CABG) had a decreased long-term mortality (p<0.05). Of the patients with PCI 27% had died, compared to 24% in those who had CABG and 36% of those who were treated medically. However, after adjusting for differences in baseline variables, conservative treatment was no significant predictor of long-term mortality. After multivariable analyses, increasing age, decreased left ventricular function and diabetes were independent predictors of long-term mortality.
  
  
  CONCLUSIONS
  In patients with coronary artery disease in whom an invasive approach is considered, increasing age, impaired left ventricular function and diabetes are the strongest predictors of long-term mortality. After adjustments for differences in baseline variables, invasive treatment is not associated with a lower long-term mortality.
authors.affiliation: Department of Cardiology, Isala Klinieken, Locatie Weezenlanden, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands.
authors.forename: Arno
authors.initials: A
authors.lastname: Breeman
authors.forename: Jorik
authors.initials: J
authors.lastname: Timmer
authors.forename: Jan Paul
authors.initials: JP
authors.lastname: Ottervanger
authors.forename: Evelien
authors.initials: E
authors.lastname: Kolkman
authors.forename: Ed
authors.initials: E
authors.lastname: de Kluiver
authors.forename: Henk
authors.initials: H
authors.lastname: Rigter
authors.forename: Piet
authors.initials: P
authors.lastname: Boonstra
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
mesh_terms: D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors