CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.
Individual CD1-restricted T cells can recognize either endogenous or foreign lipid Ags, but the extent to which the same CD1-restricted TCR can react to both self and microbial lipids is unknown. In this study, we have identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells. Remarkably, microbial Ags presented by CD1 are even more potent agonists for these same T cells. The alphabeta T cell receptors from such clones are diverse and confer specificity for both self-CD1 and foreign lipid Ags. The dual reactivity of these CD1-restricted cells suggests that the capacity for rapid responses to inflammatory stimuli without memory coexists with the capacity for strong Ag-specific responses and the generation of memory in vivo.
Vincent
Michael S
MS
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. mvicent@amgen.com
Xiong
Xiaowei
X
Grant
Ethan P
EP
Peng
Wei
W
Brenner
Michael B
MB
D018949:Antigens, CD1 / Q000235:genetics / Q000378:metabolism*; D001324:Autoantigens / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007156:Immunologic Memory; D066298:In Vitro Techniques; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014162:Transfection
D018949:Antigens, CD1; D001324:Autoantigens; C437944:CD1C protein, human; C419393:CD1a antigen; C419394:CD1b antigen; D016207:Cytokines; D006023:Glycoproteins; D016693:Receptors, Antigen, T-Cell, alpha-beta