Bone morphogenetic proteins for tendon injuries: an orthopedic primer.
Throughout the world, tendon injuries are a significant source of pain and disability. Most research on treating tendon injuries has been focused on developing new surgical techniques and perfecting existing ones. Recently, attention has turned to the biology of tendon healing as a means to improve the outcome of such injuries. If the biological milieu of the healing tendon can be altered to produce a stronger tendon, then clinical outcome can be improved. Use of bone morphogenetic proteins (BMPs) is one proposed method for improving the biology of tendon healing. BMPs 12, 13, and 14 have each been shown to improve tendon healing in animal models. In this article, I review BMP history, current research and future directions, and potential application in treating tendon injuries.
Mehta
Vishal
V
Section of Orthopaedic Surgery, Department of Surgery, MC 3079, University of Chicago Hospitals, Chicago, IL 60637, USA. vishal@mehtas.com
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D009985:Orthopedics / Q000379:methods*; D013708:Tendon Injuries / Q000188:drug therapy / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins