Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration to ostriches.
The pharmacokinetics of marbofloxacin was investigated after intravenous (IV) and intramuscular (IM) administration, both at a dose rate of 5 mg/kg BW, in six clinically healthy domestic ostriches. Plasma concentrations of marbofloxacin was determined by a HPLC/UV method. The high volume of distribution (3.22+/-0.98 L/kg) suggests good tissue penetration. Marbofloxacin presented a high clearance value (2.19+/-0.27 L/kgh), explaining the low AUC values (2.32+/-0.30 microgh/mL and 2.25+/-0.70 microgh/mL, after IV and IM administration, respectively) and a short half life and mean residence time (t(1/2 beta)=1.47+/-0.31 h and 1.96+/-0.35 h; MRT=1.46+/-0.02 h and 2.11+/-0.30 h, IV and IM, respectively). The absorption of marbofloxacin after IM administration was rapid and complete (C(max)=1.13+/-0.29 microg/mL; T(max)=0.36+/-0.071 h; MAT=0.66+/-0.22 h and F (%)=95.03+/-16.89).
de Lucas
José Julio
JJ
Cátedra de Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/Puerta de Hierro s.n., 28040 Madrid, Spain. delucas@vet.ucn.
Rodríguez
Casilda
C
Waxman
Samanta
S
González
Fernando
F
Uriarte
Isabel
I
San Andrés
Manuel Ignacio
MI
D000042:Absorption; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D008657:Metabolic Clearance Rate; D015363:Quinolones / Q000493:pharmacokinetics*; D020310:Struthioniformes / Q000097:blood / Q000378:metabolism*
D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin