title: Synthesis of 3'-deoxy-3'-C-hydroxymethyl analogues of tiazofurin and ribavirin.
abstract: On the basis of potent biological activity of 3'-branched-3'-deoxynucleoside analogues, novel ribavirin and tiazofurin derivatives with 3'-C-hydroxymethyl substituent were synthesized, starting from D-xylose.
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Myong Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Shin
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D014994:Xylose / Q000737:chemistry
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D005663:Furans; D009705:Nucleosides; D012254:Ribavirin; D014994:Xylose; C033706:tiazofurin