Landiolol attenuates the cardiovascular response to tracheal intubation.
OBJECTIVE
The objective of this prospective study was to compare the cardiovascular responses with or without landiolol to the induction of general anesthesia and tracheal intubation.


METHODS
Twenty-two patients were randomly allocated to receive a loading dose of landiolol 125 microg kg(-1) min(-1) for 1 min followed by an infusion at 40 microg kg(-1) min(-1) for 4 min, or placebo. Four minutes after landiolol or placebo was started, propofol and succinylcholine were administered. Laryngoscopy and tracheal intubation were performed 1 min after the administration of succinylcholine. Heart rate and blood pressure were measured noninvasively every minute.


RESULTS
A significant attenuation of the heart rate and blood pressure response were seen in the landiolol group for 3 min after intubation. Heart rate and systolic blood pressure in the landiolol group were decreased for 2 min before intubation and just before intubation compared with baseline, respectively.


CONCLUSIONS
Continuous administration of landiolol before tracheal intubation results in the attenuation of cardiovascular response for tracheal intubation.
Goyagi
Toru
T
Department of Anesthesiology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Tanaka
Makoto
M
Nishikawa
Toshiaki
T
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D011229:Preanesthetic Medication; D015742:Propofol; D011446:Prospective Studies; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D018686:Anesthetics, Intravenous; D009025:Morpholines; C077049:landiolol; D014508:Urea; D015742:Propofol