Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs).
The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-kappaB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.
Lee
Na Kyung
NK
Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Seoul 120-750, Korea.
Lee
Soo Young
SY
D000818:Animals; D017209:Apoptosis; D002462:Cell Membrane / Q000378:metabolism*; D002470:Cell Survival; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D020935:MAP Kinase Signaling System; D016328:NF-kappa B / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D047990:TNF Receptor-Associated Factor 1 / Q000502:physiology; D047992:TNF Receptor-Associated Factor 2 / Q000502:physiology; D048008:TNF Receptor-Associated Factor 3 / Q000502:physiology; D053449:TNF Receptor-Associated Factor 4; D048015:TNF Receptor-Associated Factor 5 / Q000502:physiology; D048029:TNF Receptor-Associated Factor 6 / Q000502:physiology; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / Q000378:metabolism / Q000502:physiology*
D007375:Interleukin-1; D016328:NF-kappa B; D011956:Receptors, Cell Surface; D047990:TNF Receptor-Associated Factor 1; D047992:TNF Receptor-Associated Factor 2; D048008:TNF Receptor-Associated Factor 3; D053449:TNF Receptor-Associated Factor 4; D048015:TNF Receptor-Associated Factor 5; D048029:TNF Receptor-Associated Factor 6; C506367:TRAF4 protein, human; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins