title: Placentitis associated with leishmaniasis in a dog.
abstract: A 1.5-year-old Coonhound from Maryland aborted 7 fetuses. Placenta and internal tissues of 1 fetus were examined histologically. The predominant lesion was placentitis characterized by necrosis and infiltration of mixed leukocytes. Numerous Leishmania spp amastigotes were identified in placental trophoblasts, and the diagnosis was confirmed by use of immunohistochemical staining with Leishmania-specific antibodies. Protozoa were not found in the fetal tissues. An indirect fluorescent antibody test yielded a serum titer of 1:100, and a recombinant K39 immunoassay of serum yielded positive results for the K39 Leishmania antigen.
authors.affiliation: Animal Parasitic Diseases Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, USDA, Bldg 1001, Beltsville, MD 20705, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Dubey
authors.forename: Alexa C
authors.initials: AC
authors.lastname: Rosypal
authors.forename: Virginia
authors.initials: V
authors.lastname: Pierce
authors.forename: Stuart N
authors.initials: SN
authors.lastname: Scheinberg
authors.forename: David S
authors.initials: DS
authors.lastname: Lindsay
mesh_terms: D000034:Abortion, Veterinary / Q000469:parasitology*; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D004285:Dogs; D005260:Female; D005333:Fetus / Q000473:pathology; D007150:Immunohistochemistry / Q000662:veterinary; D007249:Inflammation / Q000469:parasitology / Q000662:veterinary; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D009336:Necrosis / Q000662:veterinary; D010920:Placenta / Q000469:parasitology* / Q000473:pathology; D010922:Placenta Diseases / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*
chemical_list: D000913:Antibodies, Protozoan