D-dimer in the early diagnosis of acute mesenteric ischemia secondary to arterial occlusion in rats.
BACKGROUND
Early diagnosis of mesenteric ischemia can be life saving. The aim of this study is to investigate the time-dependent diagnostic value of plasma D-dimer and other ancillary laboratory evaluations such as creatine phosphokinase, lactic dehydrogenase, aspartate aminotransferase, alanine aminotransferase, amylase, and leukocyte count in an experimental superior mesenteric arterial occlusion (SMA-O) model in rats.


METHODS
Forty male Wistar-Albino rats were separated into 4 groups: 2-, 4-, 6-, and 12-hour SMA-O groups. After laparotomy, the SMA was identified and ligated for 2, 4, 6 and 12 h in the 4 respective study groups. Blood samples were taken for laboratory tests 2 h after laparotomy in the control group and at the end of the ischemic period in the study groups.


RESULTS
The longer the duration of mesenteric ischemia, the higher were the serum D-dimer levels in the study groups, and statistical significance was obtained at 2 h (p = 0.021). Sensitivity, positive predictive value, negative predictive value, and accuracy of the relation were 88.8, 88.8, 100 and 90%, respectively. Leukocyte count was significantly higher than controls after 12 h. No other laboratory parameter correlated positively with the duration of mesenteric ischemia.


CONCLUSIONS
Serum D-dimer measurements may be a valuable diagnostic parameter in the early diagnosis of mesenteric ischemia.
Kurt
Y
Y
Department of General Surgery, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
Akin
M L
ML
Demirbas
S
S
Uluutku
A H
AH
Gulderen
M
M
Avsar
K
K
Celenk
T
T
D000818:Animals; D000933:Antifibrinolytic Agents / Q000378:metabolism*; D042241:Early Diagnosis; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000175:diagnosis; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology*; D008641:Mesenteric Vascular Occlusion / Q000097:blood*; D008643:Mesentery / Q000098:blood supply*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000933:Antifibrinolytic Agents; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D