title: The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study.
abstract: OBJECTIVE
  To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects.
  
  
  METHODS
  Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study.
  
  
  METHODS
  Centres in France, Italy and Northern Ireland.
  
  
  METHODS
  A total of 387 healthy adults, aged 55-87 y.
  
  
  METHODS
  Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC.
  
  
  RESULTS
  Zinc intake was negatively correlated with urinary Pyr and Dpyr (r = -0.298 and -0.304, respectively; P < 0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r = -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r = -0.090; P < 0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (beta = -0.124; P = 0.011).
  
  
  CONCLUSIONS
  There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.
authors.affiliation: Department of Food and Nutritional Sciences, University College, Cork, Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Hill
authors.forename: N
authors.initials: N
authors.lastname: Meunier
authors.forename: M
authors.initials: M
authors.lastname: Andriollo-Sanchez
authors.forename: D
authors.initials: D
authors.lastname: Ciarapica
authors.forename: I
authors.initials: I
authors.lastname: Hininger-Favier
authors.forename: A
authors.initials: A
authors.lastname: Polito
authors.forename: J M
authors.initials: JM
authors.lastname: O'Connor
authors.forename: C
authors.initials: C
authors.lastname: Coudray
authors.forename: K D
authors.initials: KD
authors.lastname: Cashman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015930:Diet Records; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D009752:Nutritional Status / Q000502:physiology*; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood* / Q000652:urine*; D011446:Prospective Studies; D013054:Spectrophotometry, Atomic / Q000379:methods; D015032:Zinc / Q000008:administration & dosage / Q000097:blood* / Q000652:urine*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D015032:Zinc