title: Antidiabetic effect of Nitobegiku, the herb Tithonia diversifolia, in KK-Ay diabetic mice.
abstract: Nitobegiku (the herb of Tithonia diversifolia (HEMSL) A. GRAY) has been used as a medicinal plant for diabetes. The antidiabetic effect of an 80% ethanol extract of Nitobegiku (Td) was investigated in KK-Ay-mice, an animal model of type 2 diabetes. Td (500 mg/kg body weight) reduced the blood glucose of KK-Ay mice 7 h after a single oral dose. No change in blood glucose in Td-treated normal mice (ddY) was seen. Td (500 mg/kg) reduced blood glucose in KK-Ay mice 3 weeks after a single oral dose and also significantly lowered plasma insulin in KK-Ay mice under similar conditions. Td-treated KK-Ay mouse blood glucose was significantly decreased in an insulin tolerance test. These results support the hypothesis that Td improves glucose metabolism by reducing insulin resistance. Therefore, Nitobegiku may be useful for the treatment of type 2 diabetes.
authors.affiliation: Department of Clinical Nutrition, Suzuka University of Medical Science, Japan. miura@suzuka-u.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Miura
authors.forename: Kosuke
authors.initials: K
authors.lastname: Nosaka
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ishii
authors.forename: Torao
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D031202:Chrysanthemum / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D007328:Insulin; C469787:nitobegiku