title: Toxic epidermal necrolysis associated with denileukin diftitox (DAB389IL-2) administration in a patient with follicular large cell lymphoma.
abstract: Denileukin diftitox (DAB(389)IL-2 or Ontak) is a synthetic fusion protein with demonstrated efficacy in a number of lymphoproliferative disorders, including non-Hodgkin's lymphoma. We report the case of a 45-year-old man with progressive follicular large cell lymphoma following an autologous stem cell transplant treated with denileukin diftitox who developed a fatal skin rash associated with extensive erythema, edema and large bullae involving his entire body. The clinical features and pathology were compatible with toxic epidermal necrolysis. This is the first reported case of toxic epidermal necrolysis in the literature associated with denileukin diftitox.
authors.affiliation: Memorial Hermann Hospital, University of Texas Health Science Center at Houston, TX, USA.
authors.forename: Kristel
authors.initials: K
authors.lastname: Polder
authors.forename: Chiyu
authors.initials: C
authors.lastname: Wang
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
authors.forename: Abdul H
authors.initials: AH
authors.lastname: Diwan
authors.forename: Donald
authors.initials: D
authors.lastname: Parks
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Jankov
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Walker
authors.forename: Ann T
authors.initials: AT
authors.lastname: Tong
authors.forename: Joan
authors.initials: J
authors.lastname: Bull
authors.forename: Nam H
authors.initials: NH
authors.lastname: Dang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D044383:Black People; D003872:Dermatitis / Q000473:pathology; D004167:Diphtheria Toxin / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects*; D008224:Lymphoma, Follicular / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011993:Recombinant Fusion Proteins / Q000009:adverse effects; D013262:Stevens-Johnson Syndrome / Q000473:pathology*; D013781:Texas; D001741:Black or African American
chemical_list: D000970:Antineoplastic Agents; D004167:Diphtheria Toxin; D007376:Interleukin-2; D011993:Recombinant Fusion Proteins; C078456:denileukin diftitox