Two functionally distinct pools of Src kinases for PDGF receptor signalling.
The cytoplasmic tyrosine kinases of the Src family (SFK) play important roles in cell responses induced by growth factors, including cell growth, survival and migration. Here, we review how SFK participate in PDGF (platelet-derived growth factor) receptor signalling leading to DNA synthesis and actin assembly. Furthermore, evidence for a spatial compartmentalization of SFK signalling is also discussed.
Veracini
L
L
CRBM CNRS FRE 2593, 1919 Rte de Mende, 34293 Montpellier, France.
Franco
M
M
Boureux
A
A
Simon
V
V
Roche
S
S
Benistant
C
C
D000199:Actins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D008954:Models, Biological; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000378:metabolism*
D000199:Actins; D017479:Receptors, Platelet-Derived Growth Factor; D019061:src-Family Kinases