Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins.
In the current study we sought to determine whether hypothalamic IL-1beta is regulated by melanocortin signaling and if melanocortin-induced changes in energy balance are dependent on IL-1beta. A melanocortin agonist, MTII, increased hypothalamic IL-1beta mRNA levels by two-fold, whereas a melanocortin antagonist, SHU9119, blunted lipopolysaccharide (LPS)-mediated increase of hypothalamic IL-1beta content. Pharmacological or genetic disruption of IL-1 receptor signaling prevented MTII-mediated reductions in locomotor activity, but did not reduce MTII-induced anorexia. These data suggest a potential role for central melanocortins in mediating the decrease of ambulation characteristic of the 'sickness' response.
Wisse
Brent E
BE
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA. bewisse@u.washington.edu
Ogimoto
Kayoko
K
Schwartz
Michael W
MW
D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis; D007031:Hypothalamus / Q000737:chemistry / Q000378:metabolism*; D007375:Interleukin-1 / Q000235:genetics / Q000502:physiology*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009068:Movement; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction
D007375:Interleukin-1; D009074:Melanocyte-Stimulating Hormones