Similarities between ATP-dependent and ion-coupled multidrug transporters.
The movement of drugs across biological membranes is mediated by two major classes of membrane transporters. Primary-active, ABC (ATP-binding cassette) multidrug transporters are dependent on ATP-binding/hydrolysis, whereas secondary-active multidrug transporters are coupled to the proton (or sodium)-motive force that exists across the plasma membrane. Recent work on LmrA, an ABC multidrug transporter in Lactococcus lactis, suggests that primary- and secondary-active multidrug transporters share functional and structural features. Some of these similarities and their implications for the mechanism of transport by ABC multidrug transporters will be discussed.
Venter
H
H
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Shahi
S
S
Balakrishnan
L
L
Velamakanni
S
S
Bapna
A
A
Woebking
B
B
van Veen
H W
HW
D000255:Adenosine Triphosphate / Q000378:metabolism*; D017920:Antiporters / Q000378:metabolism; D018432:Drug Resistance, Multiple; D026901:Membrane Transport Proteins / Q000378:metabolism; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*
D000255:Adenosine Triphosphate; D017920:Antiporters; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins