title: New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
abstract: Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.
authors.affiliation: Southern Research Institution, Birmingham, Alabama, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Suling
authors.forename: L E
authors.initials: LE
authors.lastname: Seitz
authors.forename: R C
authors.initials: RC
authors.lastname: Reynolds
authors.forename: W W
authors.initials: WW
authors.lastname: Barrow
mesh_terms: D004094:Dihydropteroate Synthase / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D011743:Pyrimidines; C506974:SRI-8858; D004094:Dihydropteroate Synthase