title: Results of sentinel node biopsy not affected by previous excisional biopsy.
abstract: OBJECTIVE
  Sentinel lymph node (SN) biopsy has been validated in the treatment of breast carcinoma. Patients with previous excisional biopsy are regarded as ineligible for SN biopsy. We evaluated the results of SN biopsy for this group of patients based on confirmatory axillary lymph node dissection.
  
  
  METHODS
  From April 1997 all 88 patients with stage T(1-3) breast cancer who had previously undergone diagnostic excisional biopsy followed by complete axillary lymph node dissection, were enrolled into a prospective study to determine the validity of the sentinel node procedure.
  
  
  RESULTS
  Lymphoscintigraphy visualized one or more axillary hot spots in 84/88 patients. A successful SN biopsy was performed in 87 patients. Complete axillary lymph-node dissection showed no false-negative SN biopsy among the 87 SN procedures.
  
  
  CONCLUSIONS
  SN biopsy is a reliable and safe method following excisional biopsy as is confirmed by completion axillary lymph node dissection. Therefore, patients with previous excisional biopsy are eligible for sentinel node procedure and can be spared unnecessary axillary lymph node dissection.
authors.affiliation: Department of Surgery, Maaslandziekenhuis, Walramstraat 23, 6131 BK Sittard, The Netherlands. e.heuts@orbisconcern.nl
authors.forename: E M
authors.initials: EM
authors.lastname: Heuts
authors.forename: F W C
authors.initials: FW
authors.lastname: van der Ent
authors.forename: R A M
authors.initials: RA
authors.lastname: Kengen
authors.forename: H A G
authors.initials: HA
authors.lastname: van der Pol
authors.forename: K W E
authors.initials: KW
authors.lastname: Hulsewé
authors.forename: A G M
authors.initials: AG
authors.lastname: Hoofwijk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D021701:Sentinel Lymph Node Biopsy