A cautionary note on the use of the 31P NMR spectroscopy in stereochemical correlation analysis.
Stereoselectivity in condensation of protected ribonucleoside 3'-H-phosphonates with hydroxylic components was investigated using 31P NMR spectroscopy. The correlation between absolute configuration at the phosphorus center and the chemical shifts of the produced H-phosphonate diesters and the corresponding phosphorothioates, was studied.
Sobkowski
Michal
M
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14 61-704 Poznań, Poland. msob@ibch.poznan.pl
Jankowska
Jadwiga
J
Stawinski
Jacek
J
Kraszewski
Adam
A
D000431:Ethanol / Q000737:chemistry; D006151:Guanosine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry; D010758:Phosphorus; D010759:Phosphorus Isotopes / Q000737:chemistry; D011522:Protons; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods*; D013237:Stereoisomerism
D009841:Oligonucleotides; D063065:Organophosphonates; D010759:Phosphorus Isotopes; D011522:Protons; D012997:Solvents; D006151:Guanosine; D010758:Phosphorus; D000431:Ethanol