title: A longitudinal study of the influence of shift work on serum uric acid levels in workers at a telecommunications company.
abstract: BACKGROUND
  Hyperuricemia is a lifestyle-related disease. Although there have been many previous reports about the association of serum uric acid (UA) levels with lifestyle, including eating habits and alcohol intake, there has been no report of a longitudinal study of the relationship between serum UA levels and shift work.
  
  
  OBJECTIVE
  To clarify the influence of shift work on serum UA levels in Japanese workers.
  
  
  METHODS
  This was a 4-year cohort study of 15 871 workers at a telecommunications company. Pooled logistic regression analyses by sex were performed, with job schedule type, age, body mass index (BMI), lifestyle and the results of blood chemistries as covariates.
  
  
  RESULTS
  In males, shift work, part-time work, BMI, consumption of alcohol (less than twice per week, two to five times per week or more than five times per week) and little preference for vegetables were positively associated with the development of increased serum UA (>or=8 mg/dl in males, >or=6 mg/dl in females). In females, age, BMI and a history of smoking were positively associated with the development of increased serum UA.
  
  
  CONCLUSIONS
  This study revealed that shift work is independently related to increased serum UA in males.
authors.affiliation: Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuohku, Chiba 260-8670, Japan. muetani@faculty.chiba-u.jp
authors.forename: Mirei
authors.initials: M
authors.lastname: Uetani
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suwazono
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Takeya
authors.initials: T
authors.lastname: Inaba
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Oishi
authors.forename: Koji
authors.initials: K
authors.lastname: Nogawa
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology*; D012307:Risk Factors; D013685:Telecommunications; D014527:Uric Acid / Q000097:blood; D014940:Work Schedule Tolerance / Q000502:physiology*
chemical_list: D014527:Uric Acid