[Russian photosensitizer radachlorine in photodynamic therapy for epibulbar and choroid tumors: experimental studies].
The authors used the Russian agent Radachlorine as a photosensitizer (PS) in photodynamic therapy (PDT) for epibulbar and chorioid tumors. Analyzing the results suggests that the efficacy of Radachlorine used as PS in a correctly adjusted dose in PDT may be high. The optimization of effects in the experiment was observed when Radachlorine was used in a dose of 3 mg/kg with a light radiation dose of 500 mW/cm2 upon 5-min exposure. However, a rapid relapse in some cases indicates the instability of the effect and makes it necessary to make repeated PS injections and PDT sessions.
Avetisov
S E
SE
Likhvantseva
V G
VG
Reshetnikov
A V
AV
Fedorov
A A
AA
Vereshchagina
M V
MV
Balaian
M L
ML
Krupnov
R N
RN
D000818:Animals; D002735:Chlorophyllides; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005451:Fluorescein Angiography; D008297:Male; D008546:Melanoma, Experimental / Q000175:diagnosis / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011166:Porphyrins / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D011829:Radiation Dosage; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
D002735:Chlorophyllides; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin