title: Distraction osteogenesis for segmental bone defect. Physeal change after acute bone shortening followed by gradual lengthening in a rabbit tibia model.
abstract: We investigated physeal change after acute bone shortening followed by distraction osteogenesis in a rabbit tibia model. Distraction osteogenesis was performed on acutely shortened right rabbit tibia after removing a diaphyseal segment until distraction reached the length of the excised segment. Sixty animals were divided into three groups (n=20) according to the amount of shortening (20, 30, and 40% of original length) and radiographic, immunohistochemical, and histomorphometric analyses were performed to evaluate the physeal activity. The results showed no differences between groups and all animals could recover the original length without growth retardation. There was no notable venous congestion or lymphatic kinking associated with acute shortening. These results suggest that distraction osteogenesis at the primary site of shortening may have little adverse effects on the growth plate, when the shortening can provide sufficient soft tissue without vascular compromise and the amount of lengthening does not exceed that of shortening.
authors.affiliation: Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chung
authors.forename: I H
authors.initials: IH
authors.lastname: Choi
authors.forename: W J
authors.initials: WJ
authors.lastname: Yoo
authors.forename: T J
authors.initials: TJ
authors.lastname: Cho
authors.forename: H S
authors.initials: HS
authors.lastname: Gong
authors.forename: S T
authors.initials: ST
authors.lastname: Kwon
mesh_terms: D000818:Animals; D002146:Bony Callus / Q000000981:diagnostic imaging / Q000473:pathology; D004838:Epiphyses / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D023421:Models, Animal; D019857:Osteogenesis, Distraction / Q000295:instrumentation / Q000379:methods*; D011817:Rabbits; D011859:Radiography; D011897:Random Allocation; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*