title: Tissue restoration after resorption of polyglycolide and poly-laevo-lactic acid screws.
abstract: Despite worldwide clinical use of bio-absorbable devices for internal fixation in orthopaedic surgery, the degradation behaviour and tissue replacement of these implants are not fully understood. In a long-term experimental study, we have determined the patterns of tissue restoration 36 and 54 months after implantation of polyglycolic acid and poly-laevo-lactic acid screws in the distal femur of the rabbit. After 36 months in the polyglycolic acid group the specimens showed no remaining polymer and loose connective tissue occupied 80% of the screw track. Tissue restoration remained poor at 54 months, the amounts of trabecular bone and haematopoietic elements being significantly lower than those in the intact control group. The amount of trabecular bone within the screw track at 54 months in the polyglycolic acid group was less than in the empty drill holes (p = 0.04). In the poly-laevo-lactic acid group, polymeric material was present in abundance after 54 months, occupying 60% of the cross-section of the core area of the screw track. When using absorbable internal fixation implants we should recognise that the degradation of the devices will probably not be accompanied by the restoration of normal trabecular bone.
authors.affiliation: Department of Orthopaedics and Trauma Surgery, Helsinki University Hospital, P. O. Box 266, FIN-00029, Helsinki, Finland. Ole.Bostman@Helsinki.fi
authors.forename: O M
authors.initials: OM
authors.lastname: Böstman
authors.forename: O M
authors.initials: OM
authors.lastname: Laitinen
authors.forename: O
authors.initials: O
authors.lastname: Tynninen
authors.forename: S T
authors.initials: ST
authors.lastname: Salminen
authors.forename: H K
authors.initials: HK
authors.lastname: Pihlajamäki
mesh_terms: D020341:Absorbable Implants; D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D001863:Bone Screws; D001842:Bone and Bones / Q000473:pathology; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods; D006410:Hematopoiesis; D016268:Internal Fixators; D019344:Lactic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D008297:Male; D011100:Polyglycolic Acid / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011184:Postoperative Period; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; C445939:polylevolactic acid; D011100:Polyglycolic Acid; D019344:Lactic Acid