Structural biology of the thioester-dependent degradation and synthesis of fatty acids.
The fatty acid degradation and synthesis pathways consist of the same four chemical transformations. These transformations are facilitated by conjugating the fatty acid, via a thioester bond, to coenzyme A or acyl carrier protein in, respectively, the degradation and synthesis pathways. These pathways are compartmentalized in the peroxisomes, mitochondria and cytosol of eukaryotic cells. Current structural knowledge of the enzymes comprising these pathways shows that the approximately 130 entries in the RCSB Protein Data Bank can be grouped into seven superfamilies. Multifunctional enzymes are important in both pathways.
Bhaumik
Prasenjit
P
Biocenter Oulu and Department of Biochemistry, University of Oulu, Linnanmaa, PO Box 3000, FIN-90014 Oulu, Finland.
Koski
M Kristian
MK
Glumoff
Tuomo
T
Hiltunen
J Kalervo
JK
Wierenga
Rik K
RK
D000213:Acyl Carrier Protein / Q000378:metabolism; D000818:Animals; D003065:Coenzyme A / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004746:Enoyl-CoA Hydratase / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000378:metabolism*; D010084:Oxidation-Reduction; D020675:Peroxisomes / Q000378:metabolism; D011487:Protein Conformation; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D000213:Acyl Carrier Protein; D005227:Fatty Acids; D009097:Multienzyme Complexes; D013438:Sulfhydryl Compounds; D064429:Fatty Acid Synthases; D004746:Enoyl-CoA Hydratase; D003065:Coenzyme A