Claudin proteins in human cancer: promising new targets for diagnosis and therapy.
The tight junction proteins claudins are abnormally regulated in several human cancers. In particular, claudin-3 and claudin-4 are frequently overexpressed in several neoplasias, including ovarian, breast, pancreatic, and prostate cancers. Although the exact roles of these proteins in tumorigenesis are still being uncovered, it is clear that they represent promising targets for cancer detection, diagnosis, and therapy.
Morin
Patrice J
PJ
Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Baltimore, Maryland 21224, USA. Morinp@grc.nia.nih.gov
D062465:Claudin-3; D062506:Claudin-4; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D019108:Tight Junctions / Q000378:metabolism
C568122:CLDN3 protein, human; C568157:CLDN4 protein, human; D062465:Claudin-3; D062506:Claudin-4; D008565:Membrane Proteins