title: Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones.
abstract: Streptococcus pneumoniae is a major pathogen causing community-acquired pneumonia and acute bronchitis. Macrolides, fluoroquinolones (FQs), and, recently, telithromycin (TEL) constitute primary therapeutic options, and rare cases of resistance have been reported. In this report, we describe the emergence of an S. pneumoniae clinical isolate with high-level TEL resistance (MIC, 256 microg/ml) and simultaneous resistance to FQs. Ongoing studies are oriented to elucidate the precise mechanism of resistance to TEL.
authors.affiliation: Servicio Antimicrobianos, INEI-ANLIS "Dr. Carlos G. Malbrán," Av. Velez Sarsfield 563 (1281), Buenos Aires, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Faccone
authors.forename: Patricia
authors.initials: P
authors.lastname: Andres
authors.forename: Marcelo
authors.initials: M
authors.lastname: Galas
authors.forename: Marta
authors.initials: M
authors.lastname: Tokumoto
authors.forename: Adriana
authors.initials: A
authors.lastname: Rosato
authors.forename: Alejandra
authors.initials: A
authors.lastname: Corso
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D048628:Ketolides / Q000494:pharmacology; D008969:Molecular Sequence Data; D011008:Pneumococcal Infections / Q000382:microbiology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D016415:Sequence Alignment; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification*
chemical_list: D001426:Bacterial Proteins; D024841:Fluoroquinolones; D048628:Ketolides; D011500:Protein Synthesis Inhibitors; C025651:CCCGGG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific; C106791:telithromycin