title: Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: a six-month longitudinal follow-up study.
abstract: Twenty-six chemical elements and oxidative status were determined in serum of 12 patients with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried out. The results were compared with values obtained from healthy subjects living in the same geographic area. Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and Zn--elements strictly body regulated. Significant difference (p < or = 0.05) in mean concentrations of Ba, Ca, Cd, Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.
authors.affiliation: Dipartimento di Neurologia, Ospedale S. Andrea, Università degli Studi La Sapienza, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Visconti
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Cotichini
authors.forename: Stefania
authors.initials: S
authors.lastname: Cannoni
authors.forename: Beatrice
authors.initials: B
authors.lastname: Bocca
authors.forename: Giovanni
authors.initials: G
authors.lastname: Forte
authors.forename: Anna
authors.initials: A
authors.lastname: Ghazaryan
authors.forename: Simone
authors.initials: S
authors.lastname: Santucci
authors.forename: Cristina
authors.initials: C
authors.lastname: D'Ippolito
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Stazi
authors.forename: Marco
authors.initials: M
authors.lastname: Salvetti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ristori
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis; D015331:Cohort Studies; D003711:Demyelinating Diseases; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000097:blood*; D009103:Multiple Sclerosis / Q000097:blood*; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D012825:Silicon / Q000097:blood
chemical_list: D000975:Antioxidants; D008670:Metals; D016877:Oxidants; D012825:Silicon