title: Leptostatin: a synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B.
abstract: Four stereoisomeric hybrids of the polyketide natural products callystatin A and leptomycin B have been prepared by parallel synthetic routes involving chiral allenylstannane methodology. Like their natural counterparts, these hybrids exhibit nanomolar levels of cytotoxicity toward HCT-116 human colon cancer cells.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA. jam5x@virginia.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Marshall
authors.forename: Ann M
authors.initials: AM
authors.lastname: Mikowski
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Bourbeau
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Schaaf
authors.forename: Frederick
authors.initials: F
authors.lastname: Valeriote
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D005231:Fatty Acids, Unsaturated; C421091:callystatin A; C508200:leptostatin; C038753:leptomycin B