Development of functional Haemophilus influenzae type b antibodies after vaccination.
Sixteen autologous stem cell transplant recipients received three vaccinations with conjugated haemophilus influenzae type b vaccine. Quantitative and qualitative aspects of the antibody response were studied. The vaccination schedule resulted in high antibody response rates and functional maturation of antibodies, as measured by antibody avidity and phagocytosis-inducing capacity.
van der Velden
Ankie M T
AM
Claessen
Anke M E
AM
van Velzen-Blad
Heleen
H
Biesma
Douwe H
DH
Rijker
Ger T
GT
D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D016667:Bacterial Capsules; D006192:Haemophilus Infections / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use*; D019741:Haemophilus influenzae type b / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use*; D033581:Stem Cell Transplantation / Q000009:adverse effects
D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial