Serous adenocarcinoma of the sigmoid mesentery arising in cystic endosalpingiosis.
This case report describes a Mullerian serous adenocarcinoma arising within a multoloculated cyst lined by ciliated serous-type epithelium located in the sigmoid mesentery. Twenty years previously the patient underwent a hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. The ovaries contained bilateral serous cystadenofibromas, and multiple cysts lined by ciliated serous-type epithelium were present in the omentum. The resection specimen 20 years later contained a 14 cm multiloculated cyst located in the sigmoid mesentery. This was lined largely by benign ciliated serous-type epithelium but a focus of well differentiated serous adenocarcinoma projected into the lumen. Two further peritoneal cysts were present, both of which were lined by ciliated serous-type epithelium. There was a coincidental renal cell carcinoma. This is a unique case of multiple omental, peritoneal, and retroperitoneal cysts (classified as cystic endosalpingiosis), one of which developed a focus of serous adenocarcinoma. Although rarely serous adenocarcinomas, similar to those occurring within the ovary, arise in the retroperitoneum, this is the first reported occurrence in association with a pre-existing benign lesion.
McCoubrey
A
A
Department of Surgery, Ulster Hospital, Dundonald BT16 ORH, Northern Ireland.
Houghton
O
O
McCallion
K
K
McCluggage
W G
WG
D000368:Aged; D002471:Cell Transformation, Neoplastic; D018284:Cystadenocarcinoma, Serous / Q000209:etiology* / Q000473:pathology; D003560:Cysts / Q000150:complications*; D005184:Fallopian Tube Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D008643:Mesentery / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000209:etiology* / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000209:etiology* / Q000473:pathology