Nicotine prevents HIVgp120-caused electrophysiological and motor disturbances in rats.
Human immunodeficiency virus (HIV)-associated dementia (HAD) is a frequent complication in HIV+ subjects. Several electrophysiological markers and motor control are altered in HIV+ subjects, including event-related potentials (N2-P3 changes). These are electrophysiological indicators of cognitive processing. The mechanisms by which HIV induces neurophysiological abnormality is still under research. However, several neurotransmitters have been implicated. For example, glutamate and the vasoactive intestinal neuropeptide (VIP). In this study, we support further this notion indicating that HIVgp120, a glycoprotein derived from HIV, is involved in the pathogenesis of neuropsychiatric abnormalities. We also have observations suggesting that one HIVgp120 mechanism of action is to interfere with cholinergic neurotransmission. Our results indicate that event-related potentials (ERP) were affected by HIVgp120, in particular N2 and P3. In addition, motor coordination was severely affected. Both parameters were maintained near normality when rats were simultaneously treated with nicotine. These results support further an HIVgp120-caused alteration of cholinergic neurotransmission that might be part of the etiology of neuropsychiatric disturbances.
González-Lira
Británico
B
Grupo de Neurociencias, Depto. de Fisiología, Fac. de Medicina, Universidad Nacional Autónoma de México.
Rueda-Orozco
Pavel E
PE
Galicia
Oscar
O
Montes-Rodríguez
Corinne J
CJ
Guzmán
Khalil
K
Guevara-Martínez
Marcela
M
Elder
John H
JH
Prospéro-García
Oscar
O
D000818:Animals; D004347:Drug Interactions; D004569:Electroencephalography / Q000379:methods; D019054:Evoked Potentials, Motor / Q000187:drug effects*; D015699:HIV Envelope Protein gp120; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D018722:Nicotinic Agonists / Q000008:administration & dosage*; D011596:Psychomotor Disorders / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D045442:Rotarod Performance Test / Q000379:methods
D015699:HIV Envelope Protein gp120; D018722:Nicotinic Agonists; D009538:Nicotine