Highly regioselective palladium-catalyzed annulation reactions of heteroatom-substituted allenes for synthesis of condensed heterocycles.
We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In addition, subsequent functionalizations of annulated products were carried out using alkyl metal reagents, and the introduction of alkyl moieties was accomplished.
Inamoto
Kiyofumi
K
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Yamamoto
Akio
A
Ohsawa
Kazutoshi
K
Hiroya
Kou
K
Sakamoto
Takao
T
D000147:Acids, Heterocyclic / Q000138:chemical synthesis*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D000147:Acids, Heterocyclic; D010165:Palladium