The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study.
OBJECTIVE
To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects.


METHODS
Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study.


METHODS
Centres in France, Italy and Northern Ireland.


METHODS
A total of 387 healthy adults, aged 55-87 y.


METHODS
Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC.


RESULTS
Zinc intake was negatively correlated with urinary Pyr and Dpyr (r = -0.298 and -0.304, respectively; P < 0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r = -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r = -0.090; P < 0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (beta = -0.124; P = 0.011).


CONCLUSIONS
There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.
Hill
T
T
Department of Food and Nutritional Sciences, University College, Cork, Ireland.
Meunier
N
N
Andriollo-Sanchez
M
M
Ciarapica
D
D
Hininger-Favier
I
I
Polito
A
A
O'Connor
J M
JM
Coudray
C
C
Cashman
K D
KD
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D015930:Diet Records; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D009752:Nutritional Status / Q000502:physiology*; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood* / Q000652:urine*; D011446:Prospective Studies; D013054:Spectrophotometry, Atomic / Q000379:methods; D015032:Zinc / Q000008:administration & dosage / Q000097:blood* / Q000652:urine*
D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D015032:Zinc