title: Intravenous gamma globulin is effective as an urgent treatment in Brucella-induced severe thrombocytopenic purpura.
abstract: Severe thrombocytopenia is a rare hematologic manifestation of brucellosis, which can occasionally be associated with bleeding into the skin and from mucosal sites. Prompt recognition of this brucellosis complication and aggressive therapy is vital because the mortality rate associated with bleeding into the central nervous system is high. We report a case of a patient infected with Brucella melitensis who was admitted with a severe case of thrombocytopenic purpura. The patient responded well to intravenous gamma globulin (IVIg) treatment with platelet recovery within 2-3 days. For cases of Brucella-induced thrombocytopenic purpura, IVIg may be administered as an urgent therapy until the microbial therapy takes effect.
authors.affiliation: Department of Hematology, Erciyes University, Faculty of Medicine, Kayseri, Turkey. faltuntas@hotmail.com
authors.forename: Fevzi
authors.initials: F
authors.lastname: Altuntas
authors.forename: Orhan
authors.initials: O
authors.lastname: Yildiz
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Bulent
authors.initials: B
authors.lastname: Eser
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.forename: Ali
authors.initials: A
authors.lastname: Unal
mesh_terms: D000328:Adult; D002002:Brucella; D002006:Brucellosis / Q000150:complications* / Q000188:drug therapy; D003422:Critical Care; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous