Genetic, biochemical and structural approaches to talin function.
The cytoskeletal protein talin plays a key role in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton. In this paper I present a brief review on talin and summarize our recent studies, in which we have taken both genetic and structural approaches to further elucidate the function of the protein.
Critchley
D R
DR
Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. drc@le.ac.uk
D000818:Animals; D001665:Binding Sites; D003599:Cytoskeleton / Q000378:metabolism; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016608:Talin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016596:Vinculin / Q000378:metabolism
D020033:Protein Isoforms; D016608:Talin; D016596:Vinculin