title: Synthesis and study of conformationally restricted 3'-deoxy-3',4'-exo-methylene nucleoside analogues.
abstract: Hitherto unknown restricted 3'-deoxy-3',4'-exo-methylene nucleoside derivatives bearing the nucleic acid naturally occurring pyrimidine bases have been synthesized. The compounds were tested for their activity against HIV, HBV, and several RNA viruses, but they did not show significant antiviral effect.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-Université Montpellier II, Montpellier, Cedex 5, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Gagneron
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Christophe
authors.initials: C
authors.lastname: Mathé
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy; D006509:Hepatitis B / Q000188:drug therapy; D006515:Hepatitis B virus / Q000378:metabolism; D006838:Hydrocarbons / Q000138:chemical synthesis / Q000737:chemistry; D066298:In Vitro Techniques; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012328:RNA Viruses / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D006838:Hydrocarbons; D009705:Nucleosides; C030011:carbene; D008697:Methane