Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates.
We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.
Xie
Zhifang
Z
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
Siddiqi
Noman
N
Rubin
Eric J
EJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D010640:Phenothiazines / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010640:Phenothiazines