title: Topiramate for phantom limb pain: a time-series analysis.
abstract: There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.
authors.affiliation: Center for Pain Studies, Rehabilitation Institute of Chicago/Northwestern University Medical School, Chicago, Illinois 60611, USA. nharden@rehabchicago.org
authors.forename: R Norman
authors.initials: RN
authors.lastname: Harden
authors.forename: Tim T
authors.initials: TT
authors.lastname: Houle
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Remble
authors.forename: Wendy
authors.initials: W
authors.lastname: Lin
authors.forename: Kenten
authors.initials: K
authors.lastname: Wang
authors.forename: Samuel
authors.initials: S
authors.lastname: Saltz
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy* / Q000523:psychology; D010147:Pain Measurement; D010591:Phantom Limb / Q000188:drug therapy* / Q000523:psychology; D010865:Pilot Projects; D013997:Time Factors; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose