Viral pneumonias other than cytomegalovirus in transplant recipients.
Community-acquired respiratory viruses (CARVs) are frequent causes of upper and lower respiratory tract infections in transplant recipients. In most series, respiratory syncytial virus and parainfluenza are the most common CARVs, followed by influenza and adenovirus. Significant morbidity and mortality are associated with these infections, particularly when they progress to pneumonia or when they are associated with bacterial or fungal coinfections. Outcomes are also poor with adenovirus, frequently reflecting disseminated infection. Efforts to prevent morbidity and mortality from CARV infection should focus on prevention, because treatment options are limited with inconclusive data to support their efficacy.
Barton
Todd D
TD
Division of Infectious Diseases, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA. todd.barton@uphs.upenn.edu
Blumberg
Emily A
EA
D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects*; D011024:Pneumonia, Viral / Q000209:etiology*