title: Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.
abstract: A novel series of phenylamino acetamide derivatives was synthesized. These amides were shown to be potent and selective kappa opioid receptor agonists.
authors.affiliation: Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA. ghchu@adolor.com
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Chu
authors.forename: Minghua
authors.initials: M
authors.lastname: Gu
authors.forename: Joel A
authors.initials: JA
authors.lastname: Cassel
authors.forename: Serge
authors.initials: S
authors.lastname: Belanger
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Stabley
authors.forename: Robert N
authors.initials: RN
authors.lastname: DeHaven
authors.forename: Nathalie
authors.initials: N
authors.lastname: Conway-James
authors.forename: Mike
authors.initials: M
authors.lastname: Koblish
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Little
authors.forename: Diane L
authors.initials: DL
authors.lastname: DeHaven-Hudkins
authors.forename: Roland E
authors.initials: RE
authors.lastname: Dolle
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000701:Analgesics, Opioid / Q000737:chemistry* / Q000494:pharmacology; D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D006801:Humans; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000701:Analgesics, Opioid; D000814:Aniline Compounds; D017473:Receptors, Opioid, kappa; C030686:acetamide