title: Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women.
abstract: We examined the relationships among serum ferritin, alanine aminotransferase (ALT) levels, and cardiovascular risk factors of metabolic syndrome in Korean postmenopausal women. We conducted a cross-sectional study of 959 postmenopausal women without an apparent cause of liver disease. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low high-density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Serum ferritin and ALT levels were found to be correlated (r=0.374, P<.001) and to be associated with the components of metabolic syndrome. Subjects with metabolic syndrome showed significantly higher serum ferritin (74.7+/- 2.0 vs 59.6+/- 2.0 ng/mL, P<.001) and ALT levels (21.3+/-1.6 vs 18.7+/-1.5 IU/L, P<.001). Moreover, the greater the number of metabolic syndrome components present, the higher were the serum ferritin and ALT levels (P<.001). Multiple regression analysis showed that serum ALT levels are significantly associated with serum ferritin levels, waist circumference, fasting blood glucose, age, and white blood cell count (adjusted R(2)=0.147). Elevated iron stores were positively associated with serum ALT levels and metabolic syndrome in Korean postmenopausal women.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Seoul 152-050, Korea.
authors.forename: K M
authors.initials: KM
authors.lastname: Choi
authors.forename: K W
authors.initials: KW
authors.lastname: Lee
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: J A
authors.initials: JA
authors.lastname: Seo
authors.forename: S G
authors.initials: SG
authors.lastname: Kim
authors.forename: N H
authors.initials: NH
authors.lastname: Kim
authors.forename: D S
authors.initials: DS
authors.lastname: Choi
authors.forename: S H
authors.initials: SH
authors.lastname: Baik
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007723:Korea; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism*; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D005293:Ferritins; D000410:Alanine Transaminase