Metaplastic carcinoma of the breast with neuroglial differentiation.
We present a case of a 34-year-old female who had a rapidly enlarging right breast mass. Biopsy results were consistent with a neuroblastic neoplasm of the breast. Neoadjuvant chemotherapy for a neuroblastoma was performed followed by a modified radical mastectomy was performed. Final pathology revealed small foci of poorly differentiated carcinoma randomly distributed within extensive areas of neuroglial differentiation. Such a lesion has not been described in the current literature to our knowledge, and we propose that this neoplasm is a metaplastic carcinoma with a novel heterogeneous differentiation. Subsequent therapy consisted of standard adjuvant breast cancer chemotherapy and radiation therapy.
Golshan
Mehra
M
Department of Surgery Brigham and Women's Hospital 75 Francis Street, Boston, MA, 02115 USA. mgolshan@partners.org
Kuten
Adam
A
William
Jacquleine
J
Richardson
Andrea
A
Modarressi
Amir
A
Matulonis
Ursula
U
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D002454:Cell Differentiation; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009457:Neuroglia / Q000473:pathology*; D018714:Radiotherapy, Adjuvant