Tuberculosis: an uncommon cause of cerebral venous thrombosis?
Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations. We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black presented abrupt right hemiparestesis, and hemiparesis. Investigations revealed CVT. Cerebral spinal fluid (CSF) examination evidenced an infection by Mycobacterium. He was heterozygous for G20210A prothrombin mutation. Probably, hypercoagulability mechanisms of TB, added to mutation of prothrombin gene increase the risk of CVT.
Fiorot Júnior
José Antonio
JA
Division of Neurology, Universidade Federal de São Paulo, São Paulo, SP, Brazil. fiorotjr@terra.com.br
Felício
André Carvalho
AC
Fukujima
Márcia Mauimi
MM
Rodrigues
Celso Arraes
CA
Morelli
Vânia Maria
VM
Lourenço
Dayse Maria
DM
Prado
Gilmar Fernandes do
GF
D000328:Adult; D006801:Humans; D020767:Intracranial Thrombosis / Q000382:microbiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D020306:Tuberculosis, Central Nervous System / Q000150:complications*; D020246:Venous Thrombosis / Q000382:microbiology*
D011516:Prothrombin