Predictors of edge stenosis following sirolimus-eluting stent deployment (a quantitative intravascular ultrasound analysis from the SIRIUS trial).
To study the interaction of the sirolimus-eluting stent and vessel margins, we analyzed the intravascular ultrasound parameters in 317 edges of 167 stents having 18 edge stenoses at 8 months of follow-up from the SIRIUS trial. Of the baseline parameters, a larger reference percentage of plaque area and a larger edge stent area/reference minimum lumen area were associated with edge stenosis in the sirolimus-eluting stent cohort compared with the incidence of edge stenosis in the bare metal stent cohort. Thus, full lesion coverage and matching the stented segment properly to the adjacent segment using intravascular ultrasound guidance may improve sirolimus-eluting stent implantation efficacy further.
Sakurai
Ryota
R
Center for Research in Cardiovascular Interventions, Stanford University Medical Center, Stanford, California, USA.
Ako
Junya
J
Morino
Yoshihiro
Y
Sonoda
Shinjo
S
Kaneda
Hideaki
H
Terashima
Mitsuyasu
M
Hassan
Ali H M
AH
Leon
Martin B
MB
Moses
Jeffrey W
JW
Popma
Jeffrey J
JJ
Bonneau
Heidi N
HN
Yock
Paul G
PG
Fitzgerald
Peter J
PJ
Honda
Yasuhiro
Y
D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000601:surgery; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008670:Metals; D015337:Multicenter Studies as Topic; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D011475:Prosthesis Failure; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020123:Sirolimus / Q000494:pharmacology*; D015607:Stents; D018084:Ultrasonography, Interventional
D020099:Coated Materials, Biocompatible; D007166:Immunosuppressive Agents; D008670:Metals; D020123:Sirolimus