title: New acyclonucleosides: synthesis and anti-HIV activity.
abstract: The synthesis of new acyclic nucleosides is described. These syntheses were accomplished by various methods: glycosylation, selective or total deprotection, oxidation/reduction, chlorination or azidation of hydroxyl groups. The compounds were characterized with NMR, mass and IR spectroscopy. Antiviral properties of these compounds were evaluated on HIV-1 infected cell lines.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France.
authors.forename: Amel
authors.initials: A
authors.lastname: Hadj-Bouazza
authors.forename: Rachida
authors.initials: R
authors.lastname: Zerrouki
authors.forename: Pierre
authors.initials: P
authors.lastname: Krausz
authors.forename: Géraldine
authors.initials: G
authors.lastname: Laumond
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Aubertin
authors.forename: Yves
authors.initials: Y
authors.lastname: Champavier
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015497:HIV-1; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D009705:Nucleosides