Lipid-based Nose Ointment for Allergic Rhinitis.
OBJECTIVE
To assess the efficacy of a lipid-based nose ointment in treating allergic rhinitis.


METHODS
Prospective, open, randomized, controlled clinical study in the outpatient departments of 2 tertiary care centers.


RESULTS
No specific adverse effects were observed. The nose ointment under investigation led to a significant improvement in sneezing and nasal itching (17 patients). There was no significant change for nasal congestion and rhinorrhea in the intention-to-treat sets. However, there was still a significant drop of the mean relative total symptom score derived from the individual scores. All scores remained unchanged in the untreated control group (16 patients).


CONCLUSIONS
Topical application of the nose ointment as a supportive treatment leads to a significant improvement of symptoms in allergic rhinitis.


CONCLUSIONS
The prevalence of allergic rhinitis is about 10% to 20% in the population. Our study results are encouraging and should be assessed in further research because changes in the therapeutic guidelines may be suggested.


METHODS
A.
Geisthoff
Urban Wilhelm
UW
ENT Department of the University of the Saarland, Homburg/Saar, Germany. urban.geisthoff@uniklinik-saarland.de
Blum
Andreas
A
Rupp-Classen
Marianne
M
Plinkert
Peter-Karl
PK
D000281:Administration, Intranasal; D000328:Adult; D000553:Ambulatory Care; D018926:Anti-Allergic Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004337:Drug Carriers; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008055:Lipids; D008297:Male; D009824:Ointments; D011446:Prospective Studies; D012016:Reference Values; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis* / Q000188:drug therapy*; D012720:Severity of Illness Index; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D018926:Anti-Allergic Agents; D004337:Drug Carriers; D008055:Lipids; D009824:Ointments