title: [Bone and magnesium].
abstract: The half of magnesium exists in the bone. Although the long-term magnesium deficiency causes osteoporosis, most of them are accompanied by complications such as malabsorption syndrome or alcohol abuse. The animal models of magnesium deficiency show that the trabecular number or thickness is reduced, and the histological evaluation revealed that the bone formation is reduced, and bone resorption is enhanced. The trabecular bone volume, maximum load and elastic modulus are reduced. Degree of mineralization and trabecular microhardness are decreased in the hemo-dialysis patients, suggesting that bone quality is exacerbated. The magnesium takes part in the various chemical reactions in the body, but its mechanism of the regulation and the effect on the metabolism of bone are not completely understood.
authors.affiliation: Geriatric Medicine, Postgraduate School of Medicine, Osaka City University Medical School.
authors.forename: Miki
authors.initials: M
authors.lastname: Takami
authors.forename: Saitou
authors.initials: S
authors.lastname: Shinnichi
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000150:complications; D006801:Humans; D008274:Magnesium / Q000502:physiology*; D008275:Magnesium Deficiency / Q000150:complications
chemical_list: D008274:Magnesium