A comparision of the hemostatic effects of notoginseng and yun nan bai yao to placebo control.
BACKGROUND
We previously demonstrated the hemostatic effects of notoginseng using a rat bleeding model. Yun-Nan-Bai-Yao is a proprietary product for external use in China to treat bleeding but the hemostatic effects have not been proven. This study was conducted to compare the hemostatic effects of notoginseng to that of Yun-Nan- Bai-Yao and placebo control.


METHODS
Rats (n = 37) were randomized into 3 groups and their tails were transected 5mm from the tip in this blinded investigation. Group 1 received placebo (wheat flour, n = 17), group 2 received notoginseng (n = 10) and group 3 received the Yun-Nan-Bai-Yao (n = 10). The total bleeding time was determined and compared among groups.


RESULTS
Beeding time in minutes was 29.7% and 22.3% lower in the notoginseng and Yun-Nan-Bai-Yao groups than the placebo group (p < 0.001 and p < 0.001, respectively). No significant difference was found between the two active groups (p = 0.418).


CONCLUSIONS
When applied externally, both notoginseng and Yun-Nan-Bai-Yao provide appreciable hemostatic effects compared to placebo.
Fan
Chengde
C
Hartford Hospital, 80 Seymour Street, Storrs, CT 06102, USA.
Song
Jessica
J
White
C Michael
CM
D000704:Analysis of Variance; D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D005894:Panax; D008517:Phytotherapy; D015990:Placebo Effect; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D006490:Hemostatics; D010936:Plant Extracts