title: A new notch in the HIF belt: how hypoxia impacts differentiation.
abstract: In the current issue of Developmental Cell, work by Gustafsson and coworkers demonstrates that hypoxia synergizes with Notch to inhibit differentiation of myogenic and neural precursor cells. This effect requires a newly described interaction between the transcriptionally active form of HIF-1alpha and the intracellular domain of Notch.
authors.affiliation: Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Pilar
authors.initials: P
authors.lastname: Cejudo-Martin
authors.forename: Randall S
authors.initials: RS
authors.lastname: Johnson
mesh_terms: D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D004151:Dipeptides / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051880:Receptors, Notch / Q000187:drug effects / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D002219:Carbamates; D004151:Dipeptides; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C410009:L 685458; D051880:Receptors, Notch