title: N-terminal pro-brain natriuretic peptide and tombstoning ST-segment elevation in patients with anterior wall acute myocardial infarction.
abstract: Tombstoning ST-segment elevation myocardial infarction (STEMI) has been associated with a poor prognosis ever since Wimalaratna's first description of this clinical entity, and the reasons for this are not fully understood. We studied 87 consecutive patients who had anterior STEMI (January 2004 to September 2004) to compare the form of STEMI, coronary anatomy, and initial N-terminus pro-brain natriuretic peptide (NT-pro-BNP) level. Patients who had tombstoning STEMI had higher levels of NT-pro-BNP despite significant differences in cardiac enzyme levels or extent of coronary disease. This finding suggests that, in addition to changing the shape of repolarization, decreased microcirculation plays a role in the development of increased wall tension. Increased wall tension in turn is the probable cause of higher NT-pro-BNP levels and increased mortality.
authors.affiliation: The Department of Cardiology, Polyclinic of the Hospitaller Brothers of St. John of God, Budapest, Hungary. tomcsanyi.janos@axelero.hu
authors.forename: János
authors.initials: J
authors.lastname: Tomcsányi
authors.forename: András
authors.initials: A
authors.lastname: Marosi
authors.forename: Béla
authors.initials: B
authors.lastname: Bózsik
authors.forename: Miklós
authors.initials: M
authors.lastname: Somlói
authors.forename: András
authors.initials: A
authors.lastname: Zsoldos
authors.forename: Tibor
authors.initials: T
authors.lastname: Vecsey
authors.forename: Hrisula
authors.initials: H
authors.lastname: Arabadzisz
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Nagy
mesh_terms: D015415:Biomarkers / Q000097:blood; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain