title: Acid-base, coordination and oxidative properties of systems containing ATP, L-histidine and Ni(II) ions.
abstract: Potentiometric measurements of ATP-His system proved an existence of five adducts in the solution with stoichiometries ranging from H(5)(ATP)(His) to H(ATP)(His)(4-). Their formation is a consequence of electrostatic interactions only. In the ternary Ni(II)-ATP-His system, two complex species NiH(ATP)(His)(2-) and Ni(ATP)(His)(3-), were found. In the former, stacking interaction between the aromatic moiety of ATP and the imidazole ring of l-histidine is crucial to the adduct stability. All studied systems are able to generate single strand lesions of plasmid DNA in the presence of hydrogen peroxide. However, only binary systems produce linear form of DNA, which is a consequence of the accumulation of the single-stranded breaks.
authors.affiliation: Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kaczmarek
authors.forename: Wojciech
authors.initials: W
authors.lastname: Szczepanik
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jezowska-Bojczuk
mesh_terms: D000143:Acids / Q000737:chemistry; D000225:Adenine / Q000737:chemistry*; D000255:Adenosine Triphosphate / Q000737:chemistry*; D002413:Cations, Divalent; D018736:DNA Adducts / Q000737:chemistry; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000737:chemistry; D006639:Histidine / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D010957:Plasmids / Q000737:chemistry / Q000187:drug effects; D011199:Potentiometry; D055672:Static Electricity
chemical_list: D000143:Acids; D002413:Cations, Divalent; D018736:DNA Adducts; D004277:DNA, Single-Stranded; D006639:Histidine; D009532:Nickel; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D000225:Adenine