title: Relationship between bone mineral density and myocardial infarction in US adults.
abstract: Cardiovascular disease and osteoporosis have several common risk factors, and quite a few studies suggest a relationship between them. The objective of the present study was to explore the relationship between cardiovascular disease risk factors and bone mineral density in association with having had a previous myocardial infarction in a general population. This cross-sectional study was conducted using data for 5,050 women and men aged 50-79 years who participated in the Third National Health and Nutrition Examination Survey (NHANES III). Race/ethnic and gender-specific mean BMD values for young adults were used to determine race/ethnic and gender-specific T-scores to define osteoporosis and low BMD. Multiple logistic regression analysis revealed that subjects self-reporting a previous myocardial infarction had significantly higher odds (odds ratio 1.28, [95% confidence interval (CI), 1.01 to 1.63] p=0.04) of having low bone mineral density, when adjusting for cardiovascular disease and osteoporosis risk factors. Self-reported myocardial infarction was not significantly associated with low bone mineral density in women, (odds ratio 1.22, [95% CI, 0.80 to 1.86] p=0.37), but was significant in men, (odds ratio 1.39, [95% CI, 1.03 to 1.87] p=0.03). These findings demonstrate that male survivors of myocardial infarction have low bone mineral density. The pathophysiologic connection between the atherosclerotic and the osteoporotic processes needs further elucidation. It is also of importance to study the processes in both men and women.
authors.affiliation: Tulane University Health Sciences Center, School of Public Health and Tropical Medicine, 1440 Canal Street SL-29, New Orleans, LA 70112, USA. jmagnus@tulane.edu
authors.forename: Jeanette H
authors.initials: JH
authors.lastname: Magnus
authors.forename: Danielle L
authors.initials: DL
authors.lastname: Broussard
mesh_terms: D001741:Black or African American; D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology; D015519:Bone Density / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000208:ethnology / Q000503:physiopathology; D010024:Osteoporosis / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D012008:Recurrence; D012307:Risk Factors; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology; D014481:United States / Q000453:epidemiology
chemical_list: D002784:Cholesterol