title: Long-term results in patients with T2-3 N0 distal rectal cancer undergoing radiotherapy before transanal endoscopic microsurgery.
abstract: BACKGROUND
  Local excision after radiotherapy for node-negative low rectal cancer may be an alternative to radical excision. This study evaluated the results of local excision in patients with small (less than 3 cm in diameter) T2 and T3 distal rectal tumours following neoadjuvant therapy.
  
  
  METHODS
  One hundred patients with rectal cancer (54 uT2 and 46 uT3 uN0 tumours) were enrolled. All patients underwent preoperative radiotherapy followed by local excision by means of transanal endoscopic microsurgery.
  
  
  RESULTS
  Definitive histological examination revealed nine pT1, 54 pT2 and 19 pT3 tumours. A complete response (R0) or microscopic residual tumour (R1mic) was found in three and 15 patients respectively. Minor complications occurred in 11 patients and major complications in two. At a median follow-up of 55 (range 7-120) months, the local failure rate was 5 per cent and metastatic disease was found in two patients. The cancer-specific survival rate at 90 months' follow-up was 89 per cent, and the overall survival rate 72 per cent. Salvage abdominoperineal resection was performed in three patients, two of whom were disease free at 15 and 19 months.
  
  
  CONCLUSIONS
  Treatment of small uT2 and uT3 uN0 rectal cancers with preoperative high-dose radiotherapy followed by transanal endoscopic microsurgery is an acceptable alternative to conventional radical resection.
authors.affiliation: Department of Surgery Paride Stefanini, II Clinica Chirurgica, University La Sapienza, Viale del Policlinico, 00161 Rome, Italy. emanuele.lezoche@uniroma1.it
authors.forename: E
authors.initials: E
authors.lastname: Lezoche
authors.forename: M
authors.initials: M
authors.lastname: Guerrieri
authors.forename: A M
authors.initials: AM
authors.lastname: Paganini
authors.forename: M
authors.initials: M
authors.lastname: Baldarelli
authors.forename: A
authors.initials: A
authors.lastname: De Sanctis
authors.forename: G
authors.initials: G
authors.lastname: Lezoche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019160:Endosonography / Q000379:methods* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008866:Microsurgery / Q000379:methods* / Q000401:mortality; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods / Q000401:mortality; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods / Q000401:mortality