[Relationship between basal core promoter combined point mutation of hepatitis B virus and TCM syndrome type].
OBJECTIVE
To investigate the relationship between basal core promoter (BCP) combined point mutation of hepatitis B virus (HBV) and TCM syndrome type.


METHODS
One hundred and two patients with chronic hepatitis with positive HBV DNA and hadn't ever been treated by Lamivudine and interferon were differentiated according TCM syndrome differentiation into 5 types, two excess types (damp-heat blocking zhong-jiao type and blood stasis blocking collaterals type) and three deficiency types, gan-stagnation with pi-dificiency type, gan-shen yin-deficiency type and pi-shen yang-deficiency type. The serum HBV DNA, hepatic biochemical indexes, and the mutation of BCPnt 1762A-T and nt1764G-A combined point were determined, respectively.


RESULTS
The variant strain positive rate detected in the excess type was significantly higher than that in the deficiency type, the highest rate appeared in patients of damp-heat blocking zhong-jiao type.


CONCLUSIONS
BCP combined point mutation may be liable to happen in patients of TCM excess type, especially in patients of damp-heat blocking zhong-jiao type.
Zhou
Fei
F
Department of Hepatopathy, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai. zhoufeii@hotmail.com
Wang
Ling-tai
LT
Chen
Jian-jie
JJ
Zhao
Gang
G
Zhang
Bin
B
D003937:Diagnosis, Differential; D006512:Hepatitis B Core Antigens / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D008516:Medicine, Chinese Traditional; D017354:Point Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics*
D006512:Hepatitis B Core Antigens