Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
To obtain further insight into the interactions between the N-methyl-D-aspartate receptor and opioid receptor systems, we have investigated the effects of the acute treatment of morphine on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The morphine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. The present results are the first to suggest an interaction between the expression of the mRNAs for the D-serine-related enzymes and the opioid receptor activation.
Yoshikawa
Masanobu
M
Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259-1143, Japan.
Andoh
Hidehiro
H
Ito
Kenji
K
Suzuki
Toshiyasu
T
Kawaguchi
Mitsuru
M
Kobayashi
Hiroyuki
H
Oka
Tetsuo
T
Hashimoto
Atsushi
A
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003605:D-Amino-Acid Oxidase / Q000096:biosynthesis / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D019998:Racemases and Epimerases / Q000096:biosynthesis / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D000099300:Serine Racemase
D000701:Analgesics, Opioid; D003605:D-Amino-Acid Oxidase; D009020:Morphine; D012333:RNA, Messenger; D019998:Racemases and Epimerases; D016194:Receptors, N-Methyl-D-Aspartate; D011957:Receptors, Opioid; D000099300:Serine Racemase