title: Personality disorders and the trimensional personality questionnaire factors in major depressive disorder.
abstract: We assessed the potential relationship between personality disorder (PD) clusters, as assessed by the SCID-II, and temperamental traits assessed by the Tridimensional Personality Questionnaire (TPQ) among a well-characterized, unmedicated cohort of outpatients with major depressive disorder (MDD). The TPQ and SCID-II were administered to 263 depressed outpatients (mean age = 39.9 +/- 10.5 years; women = 139, 53%; initial 17-item Hamilton Rating Scale for Depression = 19.6 +/- 3.4) who currently met criteria for MDD and who were enrolled in an 8-week treatment trial. The multiple linear regression method was used to evaluate the relationship between TPQ factors and personality disorder clusters, controlling for age, gender, and initial 17-item Hamilton Rating Scale for Depression score as necessary. Among outpatients with MDD, meeting criteria for a Cluster A PD diagnosis was related to high harm avoidance (HA) scores, as well as low reward dependence and novelty seeking (NS) scores. Additionally, high HA scores were associated with meeting criteria for a Cluster C PD diagnosis, while high NS scores were associated with meeting criteria for a Cluster B PD diagnosis. Certain temperament traits, especially HA and NS, appear to be associated with specific patterns of personality clusters among depressed patients.
authors.affiliation: Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Farabaugh
authors.forename: Dost
authors.initials: D
authors.lastname: Ongur
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fava
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Hamill
authors.forename: Alana M
authors.initials: AM
authors.lastname: Burns
authors.forename: Jonathan
authors.initials: J
authors.lastname: Alpert
mesh_terms: D000328:Adult; D000367:Age Factors; D000553:Ambulatory Care; D015331:Cohort Studies; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology; D005106:Exploratory Behavior; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D010555:Personality Inventory / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012044:Regression Analysis; D012737:Sex Factors; D011795:Surveys and Questionnaires / Q000592:standards