Pharmacological properties of indazole derivatives: recent developments.
The chemistry of indazole and its N-oxide derivatives is very well-known. Indazole derivatives were extensively studied as bioactive compounds, such as anti-aggregatory and vasorelaxant activity by NO release and increase of cGMP levels and anticancer effects, antimicrobial and antiparasitic properties, among others. Recently, the research and development in the medicinal chemistry of these systems have produced compounds with contraceptive activities for men, for the treatment of osteoporosis, inflammatory disorders and neurodegenerative diseases. On the other hand, indazole N-oxide derivatives were poorly studied as bioactive compounds, but recently compounds with antiparasitic properties were produced. In this presentation, recent developments in the chemistry and medicinal chemistry of indazole and its N-oxide derivatives will be reviewed.
Cerecetto
Hugo
H
Departamento de Química Orgánica, Facultad de Química y Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay. hcerecet@fq.edu.uy
Gerpe
Alejandra
A
González
Mercedes
M
Arán
Vicente J
VJ
de Ocáriz
Carmen Ochoa
CO
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D003272:Contraceptive Agents, Male / Q000737:chemistry / Q000494:pharmacology; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007191:Indazoles / Q000737:chemistry* / Q000494:pharmacology*; D010024:Osteoporosis / Q000188:drug therapy; D010272:Parasitic Diseases / Q000188:drug therapy; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003272:Contraceptive Agents, Male; D003497:Cyclic N-Oxides; D007191:Indazoles; D014665:Vasodilator Agents