title: Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine.
abstract: Rats were trained to discriminate the 5-HT agonist m-chlorophenylpiperazine (mCPP, 1 mg/kg, i.p.) from saline. Ethanol (0.1 to 1 g/kg, i.p.) partially substituted for the discriminative stimulus effects of 1 mg/kg mCPP. Methysergide (10 mg/kg, i.p.), a 5-HT(1/2) receptor antagonist, blocked the ability of ethanol (1 g/kg) to substitute for mCPP. The largest dose of ethanol markedly reduced response rate. These findings suggest an important role of serotonin receptors in mediating the discriminative stimulus effects of ethanol.
authors.affiliation: Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699, USA. mgatch@hsc.unt.edu
authors.forename: Michael B
authors.initials: MB
authors.lastname: Gatch
mesh_terms: D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D008784:Methysergide / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*
chemical_list: D010879:Piperazines; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D000431:Ethanol; C015068:1-(3-chlorophenyl)piperazine; D008784:Methysergide