title: Substituted phenanthrenes with basic amino side chains: a new series of anti-breast cancer agents.
abstract: In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC(50) in the range of 3.53-22.25 microM. One of the compounds 15 ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, UP, India.
authors.lastname: Shagufta
authors.forename: Ajay Kumar
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Ramesh
authors.initials: R
authors.lastname: Sharma
authors.forename: Rajeev
authors.initials: R
authors.lastname: Mishra
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Balapure
authors.forename: Puvvada S R
authors.initials: PS
authors.lastname: Murthy
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D020128:Inhibitory Concentration 50; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008956:Models, Chemical; D010616:Phenanthrenes / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013629:Tamoxifen / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D010616:Phenanthrenes; D013629:Tamoxifen; D015127:9,10-Dimethyl-1,2-benzanthracene