title: Dexamethasone suppresses human interleukin-5 gene promoter.
abstract: Synthetic glucocorticoid dexamethasone suppressed interleukin-5 gene expression in PER-117 human T cells at the level of transcription. The conserved lymphokine element 0 in the interleukin-5 gene promoter context served as a target for dexamethasone.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. mordvin@bionet.nsc.ru
authors.forename: V A
authors.initials: VA
authors.lastname: Mordvinov
authors.forename: C C
authors.initials: CC
authors.lastname: Kok
authors.forename: E
authors.initials: E
authors.lastname: Arthaningtyas
authors.forename: G T F
authors.initials: GT
authors.lastname: Schwenger
authors.forename: A
authors.initials: A
authors.lastname: Cristow
authors.forename: C J
authors.initials: CJ
authors.lastname: Sanderson
mesh_terms: D002478:Cells, Cultured; D017931:DNA Primers; D003907:Dexamethasone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D015848:Interleukin-5 / Q000235:genetics* / Q000378:metabolism; D008156:Luciferases; D009841:Oligonucleotides / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000187:drug effects* / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism*; D014162:Transfection
chemical_list: D017931:DNA Primers; D015848:Interleukin-5; D009841:Oligonucleotides; D003907:Dexamethasone; D008156:Luciferases