Novel DNA nanoparticles and networks.
Joining the thrombin-binding aptamer 5-d(GGTTGGTGTGGTTGG) and the minihairpin 5-d(GCGAAGC) leads to new DNA nanoparticles, which are different from rod-like helical double-stranded DNA. Covalent interstrand cross-links in DNA duplexes generated by bifunctional alkadiyne chains were used to build-up the DNA networks.
Seela
Frank
F
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
Jawalekar
Anup M
AM
Sirivolu
Venkata R
VR
Rosemeyer
Helmut
H
He
Yang
Y
Leonard
Peter
P
D052157:Aptamers, Nucleotide / Q000737:chemistry; D020029:Base Pairing; D001665:Binding Sites; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D018014:Gene Transfer Techniques; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D011108:Polymers / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics; D013917:Thrombin / Q000737:chemistry
D052157:Aptamers, Nucleotide; D011108:Polymers; C081676:thrombin aptamer; D004247:DNA; D013917:Thrombin