Novel cyclosal nucleotides with reduced inhibitory potency toward human butyrylcholinesterase.
Two novel cycloSal-d4T monophosphates (d4TMPs) with increased steric demand have been synthesized via a new synthetic route. While 3-cyclohexyl-cycloSal d4TMP did not show a significantly reduced inhibitory potency toward human butyrylcholinesterase, the opposite was the case for the second novel pronucleotide, bis-(cycloSal-d4TMP).
Ducho
C
C
Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
Jessel
S
S
Gisch
N
N
Balzarini
J
J
Meier
C
C
D000998:Antiviral Agents / Q000494:pharmacology; D001665:Binding Sites; D002091:Butyrylcholinesterase / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008956:Models, Chemical; D009711:Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013696:Temperature
D000998:Antiviral Agents; D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D009711:Nucleotides; D002091:Butyrylcholinesterase