title: Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles.
abstract: A series of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indole derivatives have been synthesized and tested against the Gram positive and Gram negative strains of bacteria namely Staphylococcus aureus (MTCCB 737), Salmonella typhi (MTCCB 733), Pseudomonas aeruginosa (MTCCB 741), Streptomyces thermonitrificans (MTCCB 1824) and Escherichia coli (MTCCB 1652). All synthesized compounds showed mild to moderate activity. However, compounds 4d-f were found to have potent activity against pathogenic bacteria used in the study. Their MIC ranged from 3.75 to 60 microg/disc. In vitro toxicity tests demonstrated that toxicity of 4d-f was not significantly different than that of gentamycin. However, at higher concentration (1000-4000 microg/ml) difference was highly significant.
authors.affiliation: Synthetic Organic Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Tiwari
authors.forename: Devender
authors.initials: D
authors.lastname: Singh
authors.forename: Jaspal
authors.initials: J
authors.lastname: Singh
authors.forename: Vibha
authors.initials: V
authors.lastname: Yadav
authors.forename: Ajay K
authors.initials: AK
authors.lastname: Pathak
authors.forename: Rajesh
authors.initials: R
authors.lastname: Dabur
authors.forename: Anil K
authors.initials: AK
authors.lastname: Chhillar
authors.forename: Rambir
authors.initials: R
authors.lastname: Singh
authors.forename: G L
authors.initials: GL
authors.lastname: Sharma
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chandra
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Verma
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles