title: Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers.
abstract: FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
authors.affiliation: Genetic Epidemiology & Bioinformatics Group, Human Genetics Division, University of Southampton, Southampton, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ennis
authors.forename: Daniel
authors.initials: D
authors.lastname: Ward
authors.forename: Anna
authors.initials: A
authors.lastname: Murray
mesh_terms: D000367:Age Factors; D015139:Blotting, Southern; D004587:Electrophoresis, Agar Gel; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007407:Interviews as Topic; D008593:Menopause / Q000235:genetics*; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D012044:Regression Analysis; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human