Progressive multifocal leukoencephalopathy in an HTLV-I carrier.
This report describes a previously 28-year-old healthy woman, identified as an asymptomatic human T-lymphotropic virus type I (HTLV-I) carrier, who developed both progressive multifocal leukoencephalopathy (PML) and Pneumocystis jiroveci pneumonia. For diagnostic confirmation of PML, stereotactic brain biopsy demonstrated multiple demyelinating lesions with the presence of JC viral antigen. Intramuscular alpha-interferon therapy for 2 weeks brought considerable neurologic improvement. Three years later, the patient developed lymphoma-type of adult T-cell leukemia, suggesting that HTLV-I carrier might be one of the underlying diseases of PML.
Kimura
Akiko
A
Division of Neurology and Neuromuscular Disorders, Department of Brain and Nerve Science, Oita University Faculty of Medicine, Hasama-machi, Oita 879-5593, Japan.
Ueyama
Hidetsugu
H
Kimura
Noriyuki
N
Fujimoto
Shin
S
Kumamoto
Toshihide
T
D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D002353:Carrier State / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology / Q000821:virology; D015486:HTLV-I Antigens / Q000097:blood; D015490:HTLV-I Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007273:Injections, Intramuscular; D016898:Interferon-alpha / Q000008:administration & dosage; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000473:pathology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009836:Oligodendroglia / Q000473:pathology / Q000821:virology; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed
D015486:HTLV-I Antigens; D016898:Interferon-alpha