title: Impact of mass distribution of azithromycin on the antibiotic susceptibilities of ocular Chlamydia trachomatis.
abstract: In a community of Tanzania where trachoma is endemic, we cultured conjunctival swabs from all residents who had active trachoma and were PCR positive for ocular Chlamydia trachomatis, both before (43 isolates) and 2 months after (9 isolates) mass antibiotic treatment. No clinically or programmatically significant increase in azithromycin or tetracycline resistance was observed.
authors.affiliation: Clinical Research Unit, London School of Hygiene & Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. anthony.solomon@lshtm.ac.uk
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Solomon
authors.forename: Zeena
authors.initials: Z
authors.lastname: Mohammed
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Massae
authors.forename: John F
authors.initials: JF
authors.lastname: Shao
authors.forename: Allen
authors.initials: A
authors.lastname: Foster
authors.forename: David C W
authors.initials: DC
authors.lastname: Mabey
authors.forename: Rosanna W
authors.initials: RW
authors.lastname: Peeling
mesh_terms: D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D002692:Chlamydia trachomatis / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D005123:Eye / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014141:Trachoma / Q000188:drug therapy*
chemical_list: D017963:Azithromycin