[Serum levels and clinical values of soluble intercellular adhesion molecule-1 in patients with nasal polyps].
OBJECTIVE
To assess the role of soluble intercellular adhesion molecule-1 (sICAM-1) in etiology of nasal polyps.


METHODS
Twenty-nine patients with nasal polyps and 20 healthy control cases were chosen. Their serum sICAM-1 was determined by a sandwich enzyme-linked immunosorbent assay (ELISA). All patients were treated by glucocorticoid, serum sICAM-1 was determined post-treatment again.


RESULTS
(1) Serum levels of sICAM-1 in patients with nasal polyps were higher than that of control group: (2) Serum levels of sICAM-1 in patients were reduced after glucocorticoid treatment, the decrease of sICAM-1 was more apparent in evident-effect group than in effect group; (3) There was a close correlation between the decrease of polyp-size scores and the decrease of serum sICAM-1.


CONCLUSIONS
The elevated expressions of sICAM-1 in patients with nasal polyps indicate its important role in eosinophil recruitment, which was considered as a representative hallmark for nasal polyps. The sICAM-1 is down-regulated by systemic and topical glucocorticoid treatment and the decrease of sICAM-1 is correlated with clinical effect. To take these lines of evidence together, anti-adhesion therapy may be effective for nasal polyps, serum sICAM-1 levels may be use to monitor the effect of steroid therapy in nasal polyps.
Yuan
Ying
Y
Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China. yuanying1973@163.com
Luan
Xinyong
X
Zhang
Liqiang
L
Xu
Fenglei
F
Liu
Dayu
D
Lei
Dapeng
D
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000097:blood* / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
D005938:Glucocorticoids; D018799:Intercellular Adhesion Molecule-1