title: Cocaine induction of ERK proteins in dorsal striatum of Fischer rats.
abstract: Cocaine is an addictive psychostimulant that induces fos and opioid gene expression by activating the dopamine receptors and the PKA pathways in dopamine D1 and a glutamate NMDA-dependent mechanisms in the striatum. In this study, we show that a single cocaine administration induces ERK phosphorylation in the caudate/putamen of Fischer rats. This increase in Phospho-ERK is diminished by pre-administration of SCH23390, or MK801 but not with pre-administration of eticlopride. Furthermore, this single cocaine administration does not alter the levels of phospho-CREB protein or CREB-DNA bindings in the caudate/putamen protein extracts but does increase phospho-Elk-1 protein levels in the same extracts.
authors.affiliation: Department of Psychology, Hunter College of The City University of New York, NY 10021, USA.
authors.forename: Shirzad
authors.initials: S
authors.lastname: Jenab
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Festa
authors.forename: Arbi
authors.initials: A
authors.lastname: Nazarian
authors.forename: Hui Bing K
authors.initials: HB
authors.lastname: Wu
authors.forename: Wei Lun
authors.initials: WL
authors.lastname: Sun
authors.forename: Ruhal
authors.initials: R
authors.lastname: Hazim
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Russo
authors.forename: Vanya
authors.initials: V
authors.lastname: Quinones-Jenab
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D015153:Blotting, Western / Q000379:methods; D003042:Cocaine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D024202:Electrophoretic Mobility Shift Assay / Q000379:methods; D004790:Enzyme Induction / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012457:Salicylamides / Q000494:pharmacology
chemical_list: D001552:Benzazepines; D017362:Cyclic AMP Response Element-Binding Protein; D018492:Dopamine Antagonists; D018765:Dopamine Uptake Inhibitors; D018691:Excitatory Amino Acid Antagonists; D012457:Salicylamides; D016291:Dizocilpine Maleate; D020928:Mitogen-Activated Protein Kinases; D003042:Cocaine; C045989:eticlopride