title: Helicases that interact with replication forks: new candidates from archaea.
abstract: Overcoming DNA replication fork blocks is essential for completing genome duplication and cell division. Archaea and eukaryotes drive replication using essentially the same protein machinery. Archaea may be a valuable resource for identifying new helicase components at advancing forks and/or in replication-restart pathways. As described here, these may be relevant to understanding genome instability in metazoans.
authors.affiliation: Institute of Genetics, School of Biology, Queen's Medical Centre, University of Nottingham, Nottingham NG 72UH, UK. ed.bolt@nottingham.ac.uk
authors.forename: E L
authors.initials: EL
authors.lastname: Bolt
mesh_terms: D001105:Archaea / Q000201:enzymology*; D019843:Archaeal Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D009690:Nucleic Acid Conformation; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D004265:DNA Helicases