Are pharmaceuticals potent environmental pollutants? Part I: environmental risk assessments of selected active pharmaceutical ingredients.
As part of achieving national environmental goals, the Swedish Government commissioned an official report from the Swedish Medical Products Agency on environmental effects of pharmaceuticals. Considering half-lives/biodegradability, environmental occurrence, and Swedish sales statistics, 27 active pharmaceutical ingredients were selected for environmental hazard and risk assessments. Although there were large data gaps for many of the compounds, nine ingredients were identified as dangerous for the aquatic environment. Only the sex hormones oestradiol and ethinyloestradiol were considered to be associated with possible aquatic environmental risks. We conclude that risk for acute toxic effects in the environment with the current use of active pharmaceutical ingredients is unlikely. Chronic environmental toxic effects, however, cannot be excluded due to lack of chronic ecotoxicity data. Measures to reduce potential environmental impact posed by pharmaceutical products must be based on knowledge on chronic ecotoxic effects of both active pharmaceutical ingredients as well as excipients. We believe that the impact pharmaceuticals have on the environment should be further studied and be given greater attention such that informed assessments of hazards as well as risks can be done.
Carlsson
Carina
C
Swedish Medical Products Agency, PO Box 26, SE-751 03 Uppsala, Sweden. carina.carlsson@mpa.se
Johansson
Anna-Karin
AK
Alvan
Gunnar
G
Bergman
Kerstin
K
Kühler
Thomas
T
D004345:Drug Industry; D064420:Drug-Related Side Effects and Adverse Reactions; D017753:Ecosystem; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis / Q000331:legislation & jurisprudence; D004784:Environmental Monitoring / Q000331:legislation & jurisprudence / Q000379:methods; D007220:Industrial Waste / Q000009:adverse effects*; D004364:Pharmaceutical Preparations / Q000032:analysis; D011634:Public Health; D018570:Risk Assessment; D013548:Sweden; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis
D007220:Industrial Waste; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical