The contributions of biosynthesis and acyl chain remodelling to the molecular species profile of phosphatidylcholine in yeast.
Phosphatidylcholine (PC) is a very abundant membrane lipid in most eukaryotes, including yeast. The molecular species profile of PC, i.e. the ensemble of PC molecules with acyl chains differing in number of carbon atoms and double bonds, is important for membrane function. Pathways of PC synthesis and turnover maintain PC homoeostasis and determine the molecular species profile of PC. Studies addressing the processes involved in establishing the molecular species composition of PC in yeast using stable isotope labelling combined with detection by MS are reviewed.
Boumann
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HA
Department Biochemistry of Membranes, Bijvoet Institute and Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
de Kroon
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D010713:Phosphatidylcholines / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013045:Species Specificity; D013329:Structure-Activity Relationship
D010713:Phosphatidylcholines