[Stereoselective pharmacokinetics of tetrahydropalmatine in rats].
OBJECTIVE
To investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.


METHODS
The concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.


RESULTS
The plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.


CONCLUSIONS
Tetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate.
Hong
Zhan-Ying
ZY
Shanghai Key Laboratory for Pharmaceutical Metabolites Research, School of Pharmacy, Second Military Medical University PLA, Shanghai, China.
Fan
Guo-Rong
GR
Chai
Yi-Feng
YF
Wen
Jun
J
Yin
Xue-Ping
XP
Wu
Yu-Tian
YT
D000818:Animals; D019540:Area Under Curve; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D031311:Corydalis / Q000737:chemistry; D005260:Female; D008297:Male; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D001600:Berberine Alkaloids; C014215:tetrahydropalmatine