Genetic determinants of blood pressure regulation.
Hypertension is a multifactorial disorder that probably results from the inheritance of a number of susceptibility genes and involves multiple environmental determinants. Existing evidence suggests that the genetic contribution to blood pressure variation is about 30-50%. Although a number of candidate genes have been studied in different ethnic populations, results from genetic analysis are still inconsistent and specific causes of hypertension remain unclear. Furthermore, the abundance of data in the literature makes it difficult to piece together the puzzle of hypertension and to define candidate genes involved in the dynamic of blood pressure regulation. In this review, we attempt to highlight the genetic basis of hypertension pathogenesis, focusing on the most important existing genetic variations of candidate genes and their potential role in the development of this disease. Our objective is to review current knowledge and discuss limitations to clinical applications of genotypic information in the diagnosis, evaluation and treatment of hypertension. Finally, some principles of pharmacogenomics are presented here along with future perspectives of hypertension.
Marteau
Jean-Brice
JB
INSERM U525, Equipe 4, Faculté de Pharmacie, Université Henri Poincare, Nancy, France.
Zaiou
Mohamed
M
Siest
Gérard
G
Visvikis-Siest
Sophie
S
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics; D001794:Blood Pressure / Q000187:drug effects / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D016232:Endothelins / Q000235:genetics; D053503:Epithelial Sodium Channels; D014644:Genetic Variation; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology*; D008955:Models, Cardiovascular; D010597:Pharmacogenetics; D011943:Receptors, Adrenergic, beta / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D012964:Sodium / Q000378:metabolism; D015222:Sodium Channels / Q000235:genetics
D016207:Cytokines; D016232:Endothelins; D053503:Epithelial Sodium Channels; D011943:Receptors, Adrenergic, beta; D015222:Sodium Channels; D009320:Atrial Natriuretic Factor; D012964:Sodium