A combined approach for locating box H/ACA snoRNAs in the human genome.
A novel combined method for locating box H/ACA small nucleolar RNAs (snoRNAs) is described, together with a software tool. The method adopts both a probabilistic hidden Markov model (HMM) and a minimum free energy (MFE) rule, and filters possible candidate box H/ACA snoRNAs obtained from genomic DNA sequences. With our novel method 12 known box H/ACA snoRNAs, and one strong candidate were identified in 30 nucleolar protein genomic sequences.
Eo
Hae Seok
HS
School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
Jo
Kwang Sun
KS
Lee
Seung Won
SW
Kim
Chang-Bae
CB
Kim
Won
W
D000465:Algorithms; D001483:Base Sequence; D030561:Databases, Nucleic Acid; D004735:Energy Transfer / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008390:Markov Chains; D008954:Models, Biological; D008969:Molecular Sequence Data; D020537:RNA, Small Nucleolar / Q000235:genetics*; D015203:Reproducibility of Results; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D012984:Software / Q000592:standards*
D020537:RNA, Small Nucleolar