Host receptors in malaria merozoite invasion.
The clinical manifestations of Plasmodium falciparum malaria are directly linked to the blood stage of the parasite life cycle. At the blood stage, the circulating merozoites invade erythrocytes via a specific invasion pathway often identified with its dependence or independence on sialic acid residues of the host receptor. The invasion process involves multiple receptor-ligand interactions that mediate a complex series of events in a period of approximately 1 min. Although the mechanism by which merozoites invade erythrocytes is not fully understood, recent advances have put a new perspective on the importance of developing a multivalent blood stage-malaria vaccine. In this review, we highlight the role of currently identified host invasion receptors in blood-stage malaria.
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Division of Cell Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.
Chishti
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D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000502:physiology; D004375:Duffy Blood-Group System / Q000502:physiology; D004912:Erythrocytes / Q000469:parasitology*; D006021:Glycophorins / Q000502:physiology; D006790:Host-Parasite Interactions; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology*; D010961:Plasmodium / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology
C473745:ACKR1 protein, human; D001457:Anion Exchange Protein 1, Erythrocyte; D004375:Duffy Blood-Group System; D006021:Glycophorins; D011956:Receptors, Cell Surface