Hypotensive activity and toxicology of constituents from root bark of Polyalthia longifolia var. pendula.
A defatted extract of Polyalthia longifolia var. pendula root bark (PRB) in 50% methanol showed a significant ability to reduce blood pressure. It caused a 22% and 47% fall in mean arterial blood pressure (MABP) in rats at doses of 3 mg/kg and 30 mg/kg, respectively. Compounds purified from this extract include kolavenic acid (3), clerodane (1) and its isomer (2), liriodenine (4), lysicamine (5) and bisclerodane imide (6) and its isomer (7). Of these, only kolavenic acid produced a 22% fall in MABP, at a dose of 30 mg/kg. PRB showed a decrease in blood pressure of normotensive and egg yolk induced hypertensive rats. The LD50 of PRB was determined as 100 mg/kg in mice.
Saleem
Rubeena
R
Dr. HMI Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi-74600, Pakistan. rs127pk@yahoo.com
Ahmed
Muhammad
M
Ahmed
Syed Iqbal
SI
Azeem
Mohammad
M
Khan
Rashid Ali
RA
Rasool
Najma
N
Saleem
Hina
H
Noor
Fatima
F
Faizi
Shaheen
S
D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004530:Egg Yolk; D006973:Hypertension / Q000188:drug therapy; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D031044:Polyalthia; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D010936:Plant Extracts