title: Subacute cutaneous lupus erythematosus associated with leflunomide.
abstract: A skin eruption consistent with subacute cutaneous lupus erythematosus (SCLE) occurred in a patient taking leflunomide for rheumatoid arthritis. The eruption resolved after discontinuation of the medication. Suppression of tumor necrosis factor (TNF)-effector mechanisms by leflunomide may have played a role in the pathogenesis of this disorder.
authors.affiliation: Dermatology Clinic, US Army Medical Department Activity, Fort Drum, New York 13602, USA. anthony.elias@us.army.mil
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Elias
authors.forename: Christine C
authors.initials: CC
authors.lastname: Tam
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: David-Bajar
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D000077339:Leflunomide; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced*; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007555:Isoxazoles; D000077339:Leflunomide