title: Dose reduction for CT in children with cystic fibrosis: is it feasible to reduce the number of images per scan?
abstract: BACKGROUND
  Reducing the dose for each CT scan is important for children with cystic fibrosis (CF).
  
  
  OBJECTIVE
  To determine whether the number of CT images and therefore the dose per CT scan could be reduced without any significant loss of information in children with CF.
  
  
  METHODS
  A cohort of children with CF was followed with biennial surveillance CT scans, obtained in inspiration after a voluntary breath-hold as 1-mm thick images at 10-mm intervals from lung apex to base. A random set of 20 baseline CT scans and 10 follow-up CT scans were blinded. Sets of every image (10-mm intervals), every second image (20-mm intervals), every third image (30-mm intervals) and a selection of three and five images were scored randomly using a published CT scoring system by one experienced observer.
  
  
  RESULTS
  The 20 subjects were 10 years of age with a range of 3.7-17.6 years at baseline. Fewer CT images resulted in a significantly lower (less abnormal) CT score and the number of patients positive for abnormalities decreased subsequently. At intervals greater than 20 mm no significant change in CT score over 2 years could be detected, while the CT scores at 10-mm (P=0.02) and 20-mm (P=0.02) intervals worsened significantly.
  
  
  CONCLUSIONS
  A reduction in the number of inspiratory CT images by increasing the interval between images to greater than 10 mm is not a valid option for radiation dose reduction in children with CF.
authors.affiliation: Department of Paediatric Pulmonology and Allergology, Erasmus MC, Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands.
authors.forename: Pim A
authors.initials: PA
authors.lastname: de Jong
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Nakano
authors.forename: Maarten H
authors.initials: MH
authors.lastname: Lequin
authors.forename: Harm A W M
authors.initials: HA
authors.lastname: Tiddens
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging*; D005240:Feasibility Studies; D006801:Humans; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards*