The fundamental theorem of neutral evolution: rates of substitution and mutation should factor in premeiotic clusters.
Mutations do not always arise as single events. Many new mutations actually occur in the cell lineage before germ cell formation or meiosis and are therefore replicated pre-meiotically. The increased likelihood of substitutions caused by these clusters of new mutant alleles can change the fundamental theorem of neutral evolution.
Woodruff
R C
RC
Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA. rwoodru@bgnet.bgsu.edu
Thomson
J N
JN
D000483:Alleles; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008540:Meiosis / Q000235:genetics; D008957:Models, Genetic; D005810:Multigene Family; D009154:Mutation