The RGK family: a regulatory tail of small GTP-binding proteins.
RGK proteins are small Ras-related GTP-binding proteins that function as potent inhibitors of voltage-dependent calcium channels, and two members of the family, Gem and Rad, modulate Rho-dependent remodeling of the cytoskeleton. Within the Ras superfamily, RGK proteins have distinct structural and regulatory characteristics. It is an open question as to whether RGK proteins catalyze GTP hydrolysis in vivo. Binding of calmodulin and the 14-3-3 protein to RGK proteins controls downstream pathways. Here, we discuss the structural and functional properties of RGK proteins and highlight recent work by Beguin and colleagues addressing the mechanism of Gem regulation by calmodulin and 14-3-3.
Kelly
Kathleen
K
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute/NIH, Building 37, Room 1068, Bethesda, MD 20892, USA. kkelly@helix.nih.gov
D048948:14-3-3 Proteins / Q000502:physiology; D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D002147:Calmodulin / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D017874:Immediate-Early Proteins / Q000737:chemistry / Q000502:physiology; D051379:Mice; D020559:Monomeric GTP-Binding Proteins / Q000737:chemistry* / Q000502:physiology*
D048948:14-3-3 Proteins; D015220:Calcium Channels; D002147:Calmodulin; D017874:Immediate-Early Proteins; C490245:GEM protein, human; C088119:Gem protein, mouse; D020559:Monomeric GTP-Binding Proteins