title: Design of highly efficient and selective transfer reaction of nitrosyl group to dc and d(M)C resulting in specific deamination.
abstract: Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific deamination.
authors.affiliation: CREST, Japan Science and Technology Agency, Japan.
authors.forename: M Monsur
authors.initials: MM
authors.lastname: Ali
authors.forename: Fumi
authors.initials: F
authors.lastname: Nagatsugi
authors.forename: Shizuka
authors.initials: S
authors.lastname: Nakayama
authors.forename: M Rowshon
authors.initials: MR
authors.lastname: Alam
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry; D003641:Deamination; D006151:Guanosine / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D008969:Molecular Sequence Data; D009154:Mutation; D009569:Nitric Oxide / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry*; D009603:Nitroso Compounds / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013997:Time Factors
chemical_list: D009603:Nitroso Compounds; D009841:Oligonucleotides; D013438:Sulfhydryl Compounds; D006151:Guanosine; D009569:Nitric Oxide; D004247:DNA; D009584:Nitrogen