title: The kinome is not enough.
abstract: Mechanism of action studies are essential to link observable effects on cells with molecular targets of small molecules. Caligiuri and coworkers describe how yeast three-hybrid screening identified kinases that might mediate an intriguing tumor cell-specific antiproliferative effect.
authors.affiliation: Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor, 48105, USA.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Toogood
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D013379:Substrate Specificity; D020798:Two-Hybrid System Techniques; D015003:Yeasts / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D010770:Phosphotransferases