title: cadherin-6 message expression in the nervous system of developing zebrafish.
abstract: Cadherins are cell surface adhesion molecules that play important roles in development of a variety of tissues including the nervous system. In this study, we analyzed expression pattern of cadherin-6, a member of the type II cadherin subfamily, in the embryonic zebrafish nervous system using in situ hybridization methods. cadherin-6 message is first expressed by the neural keel, then by restricted regions in the brain and spinal cord. cadherin-6 expression in the brain transiently delineates specific brain regions. In the peripheral nervous system, cadherin-6 message is expressed by the neurogenic placodes and the dorsal root ganglia. As development proceeds, cadherin-6 expression domain and/or expression levels increased in the embryonic nervous system. Our results show that cadherin-6 expression in the zebrafish developing nervous system is both spatially and temporally regulated, implicating a role for cadherin-6 in the formation of these nervous structures.
authors.affiliation: Department of Biology, University of Akron, Akron, Ohio 44325-3908, USA. qliu@uakron.edu
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Bei
authors.initials: B
authors.lastname: Liu
authors.forename: Amy L
authors.initials: AL
authors.lastname: Wilson
authors.forename: Jason
authors.initials: J
authors.lastname: Rostedt
mesh_terms: D000818:Animals; D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics*; D002490:Central Nervous System / Q000737:chemistry / Q000378:metabolism*; D017933:Peripheral Nervous System / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism
chemical_list: D015820:Cadherins; D012333:RNA, Messenger; C087310:K cadherin