[Progress on genetic susceptibility to ankylosing spondylitis].
Ankylosing spondylitis (AS) is a highly heritable, common inflammatory rheumatic disease. Since 1970s, evidence has increasingly pointed to HLA-B27 as the major gene involved in susceptibility to AS. However, genome-wide scan and association studies have shown, in addition to HLA, regions outside the HLA are involved in susceptibility to AS. Furthermore, there is compelling evidence that non-B27 genes, either within or outside the HLA, are involved in disease aetiology. This review mainly summarized different genes associated with AS, and the current progress in this exciting area.
Chen
Rui-Wen
RW
Institute of Medical Biotechnology & Molecular Genetics, Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China. rwchen@smmu.edu.cn
Wang
Yong
Y
Sun
Shu-Han
SH
Duan
Shi-Wei
SW
D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D015810:Linkage Disequilibrium; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D015235:HLA-B Antigens; D007375:Interleukin-1; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D019389:Cytochrome P-450 CYP2D6