N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.
Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.
Du
Jinfa
J
Pharmasset, Inc., 1860 Montreal Road, Tucker, GA 30084, USA. jdu@pharmasset.com
Hollecker
Laurent
L
Shi
Junxing
J
Chun
Byoung-Kwon
BK
Watanabe
Kyoichi A
KA
Raymond
F Schinazi
FS
Nachman
Tammy Y
TY
Lostia
Stefania
S
Stuyver
Lieven J
LJ
Otto
Michael J
MJ
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003596:Cytosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D004148:Dioxolanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006515:Hepatitis B virus; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D004148:Dioxolanes; D009705:Nucleosides; D003596:Cytosine; C010962:formal glycol