[Defect of glycosylation of immunoglobulin G in rheumatoid arthritis patients].
Rheumatoid arthritis (RA) is a multisystem disorder in which immunological abnormalities result in symmetrical joint inflammation, articular erosion, and extra-articular involvement. The etiology of RA is still unknown, but a defect in the glycosylation of IgG may be involved in its immunopathogenesis. Several studies have shown a correlation between the amount of IgG lacking galactose and the activity of RA. IgG galactosylation has been shown to be a useful marker of early RA and an indicator of poor prognosis. Analysis of IgG galactosylation may offer an insight into disease pathogenesis and may also be useful in RA diagnosis.
Gińdzieńska-Sieśkiewicz
Ewa
E
Klinika Reumatologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku. ewajsieskiewicz@op.pl
Klimiuk
Piotr Adrian
PA
Domysławska
Izabela
I
Sierakowski
Stanisław
S
D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D005690:Galactose / Q000032:analysis; D006031:Glycosylation; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D011379:Prognosis
D015415:Biomarkers; D007074:Immunoglobulin G; D005690:Galactose