title: A matter of motion or an emotional matter? Management of depression in Parkinson's disease.
abstract: Depression is one of the most frequent comorbidities occurring in Parkinson's disease, affecting up to 50% of patients. Depression is associated with severe negative symptoms and has been shown to contribute to an increased rate of decline of both cognitive and motor function, profoundly impacting on the patient's quality of life. The symptoms of depression overlap with the motor features of Parkinson's disease, making detection difficult. Moreover, the lack of specialized screening tools means that depression remains undiagnosed and untreated in a high percentage of patients. However, depression in Parkinson's disease, when identified early, can be effectively treated with a variety of antidepressant medications, improving quality of life and preserving daily function. The focus of this review is to provide an overview of current knowledge regarding depression in Parkinson's disease, followed by a practical discussion addressing the issues of the detection, diagnosis and treatment.
authors.affiliation: School of Psychiatry, The University of New South Wales, Australia.
authors.forename: Jim
authors.initials: J
authors.lastname: Lagopoulos
authors.forename: Gin S
authors.initials: GS
authors.lastname: Malhi
authors.forename: Belinda
authors.initials: B
authors.lastname: Ivanovski
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Cahill
authors.forename: John G L
authors.initials: JG
authors.lastname: Morris
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D003863:Depression / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005104:Expert Testimony; D006801:Humans; D009038:Motion; D010300:Parkinson Disease / Q000150:complications* / Q000453:epidemiology
chemical_list: D000928:Antidepressive Agents