Quantification of the effects of melittin on liposome structure.
An optical technique, dual-polarization interferometry, has been used to examine lipid structures at the solid/liquid interface. Changes in the lipid structures, in real time, were examined as a consequence of challenging them with a peptide (melittin) that is known to induce liposome rupture. This work suggests that it should be possible to obtain a better understanding of the detail of the melittin rupture process.
Popplewell
J
J
Farfield Sensors Ltd, Unit 51, Salford University Business Park, Salford, Greater Manchester M6 6AJ, UK.
Freeman
N
N
Carrington
S
S
Ronan
G
G
McDonnell
C
C
Ford
R C
RC
D005454:Fluorescence Polarization; D008051:Lipid Bilayers; D008081:Liposomes / Q000737:chemistry*; D008555:Melitten / Q000737:chemistry*; D010713:Phosphatidylcholines
D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D008555:Melitten; C017251:1,2-oleoylphosphatidylcholine