[Cardiac ion channel disorders--diagnosis and treatment].
BACKGROUND
Inherited arrhythmogenic disorders are a group of genetically determined diseases characterised by ventricular tachyarrhythmias sometimes leading to sudden death. The molecular bases of these disorders are mutations in genes coding for various cardiac ion channels. The most common cardiac ion channel disease is the long QT syndrome. This syndrome is rare, but probably more common in Norway than previously expected. We have recently started genetic testing for cardiac ion channel disorders at Rikshospitalet University Hospital in Oslo. This review describes the current understanding of the etiology, prognosis and management of cardiac ion channel disorders, based on literature and our own clinical experience.


CONCLUSIONS
Cardiac ion channel disorders may lead to sudden cardiac death. Prophylactic and life-saving therapies are available for many of these disorders. Therapy and risk stratification depend on the clinical presentation, the ECG pattern, and which gene is mutated. Genetic testing offers the opportunity to exclude individual family members as mutation carriers.
Haugaa
Kristina Hermann
KH
Hjertemedisinsk avdeling, Rikshospitalet, 0027 Oslo. kristina.haugaa@rikshospitalet.no
Berge
Knut Erik
KE
Früh
Andreas
A
Anfinsen
Ole-Gunnar
OG
Arnestad
Marianne
M
Hallerud
Maria
M
Gjesdal
Knut
K
Leren
Trond P
TP
Amlie
Jan Peder
JP
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D002037:Bundle-Branch Block / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D002648:Child; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D009154:Mutation; D010641:Phenotype; D015221:Potassium Channels / Q000235:genetics / Q000502:physiology; D011379:Prognosis; D012307:Risk Factors; D015222:Sodium Channels / Q000235:genetics / Q000502:physiology; D013577:Syndrome
D015221:Potassium Channels; D015222:Sodium Channels