Efficient rhodium-catalyzed asymmetric hydrogenation for the synthesis of a new class of N-aryl beta-amino acid derivatives.
[reaction: see text] N-Aryl beta-amino esters were obtained by asymmetric hydrogenation of a new class of N-aryl beta-enamino esters. High conversions and up to 96.3% ee values were achieved with a Rh-TangPhos catalyst.
Dai
Qian
Q
Department of Chemistry, The Pennsylvania State University, 104 Chemistry Building, University Park, Pennsylvania 16802, USA.
Yang
Weiran
W
Zhang
Xumu
X
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000145:classification; D002384:Catalysis; D006865:Hydrogenation; D007202:Indicators and Reagents; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000596:Amino Acids; D007202:Indicators and Reagents; D012238:Rhodium