title: ADAM33: a newly identified gene in the pathogenesis of asthma.
abstract: There is much to find out about this fascinating and complex molecule in relation to the development and progression of asthma. Added to it are three further new asthma/allergy genes identified by positional cloning: PDH Finger Protein II (PHF11) on chromosome 13q14, which encodes NY-REN-34 a protein first described in patients with renal cell carcinoma [67]; Dipeptidyl diptidase 10 (DDP10) on chromosome 2q14 [68]; and G protein-coupled receptor for asthma susceptibility (GPRA) on chromosome 7p [69]. For each of these genes, as is the case for ADAM33, determining their normal function(s) and how these become disordered in asthma is the future challenge.
authors.affiliation: Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK. sth@soton.ac.uk
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Holgate
authors.forename: Donna E
authors.initials: DE
authors.lastname: Davies
authors.forename: Rob M
authors.initials: RM
authors.lastname: Powell
authors.forename: John W
authors.initials: JW
authors.lastname: Holloway
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human