Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression.
In this study, we examined the impact of preoperative anti-A/B antibody titers on the results of ABO-incompatible living kidney transplantation (LKT). In all, 167 recipients underwent ABO-incompatible LKT at our institution between 1989 and 2002. These patients were subdivided into those transplanted under cyclosporine with azathioprine or mizoribine (Group 1, n=78) and those transplanted under tacrolimus or mycophenolate mofetil (Group 2, n=89). Overall patient survival at 5 and 10 years was 93.8% and 88.0%, respectively. Overall graft survival at 5 and 10 years was 76.9% and 55.9%, respectively. Graft survival in the patients with anti-A/B IgG titers over 1:128 was significantly lower in group 1, whereas no significant correlation between the anti-A/B IgG titers and graft survival was found in group 2. In conclusion, no correlation between anti-A/B antibody titers and the results of ABO-incompatible LKT was seen after tacrolimus or mycophenolate mofetil application.
Shimmura
Hiroaki
H
Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan. shimmura@kc.twmu.ac.jp
Tanabe
Kazunari
K
Ishida
Hideki
H
Tokumoto
Tadahiko
T
Ishikawa
Nobuo
N
Miyamoto
Naoshi
N
Shirakawa
Hiroki
H
Setoguchi
Kiyoshi
K
Nakajima
Ichiro
I
Fuchinoue
Shouhei
S
Teraoka
Satoshi
S
Toma
Hiroshi
H
D000017:ABO Blood-Group System / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood; D001787:Blood Group Incompatibility / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged
D000017:ABO Blood-Group System; D000906:Antibodies; D007074:Immunoglobulin G