title: Strain-specific mycobacterial lipids and the stimulation of protective immunity to tuberculosis.
abstract: Control of Mycobacterium tuberculosis (M. tuberculosis) infection is dependent on recognition of bacilli by cells of the innate immune system in the lung and the subsequent generation of an acquired effector T lymphocyte response. Lipid moieties of M. tuberculosis are important stimulators of innate immunity mediated predominantly through recognition by Toll-like receptors. In this paper, we will discuss how the lipid composition of different clinical isolates (strains) of M. tuberculosis affect that strain's ability to direct innate immunity, and ultimately influence whether infection is controlled or active disease develops.
authors.affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, Newark, NJ, USA. mmendels@curie.uct.ac.za
authors.forename: Marc
authors.initials: M
authors.lastname: Mendelson
authors.forename: Shaun
authors.initials: S
authors.lastname: Walters
authors.forename: Issar
authors.initials: I
authors.lastname: Smith
authors.forename: Gilla
authors.initials: G
authors.lastname: Kaplan
mesh_terms: D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000276:immunology*; D008213:Lymphocyte Activation; D009161:Mycobacterium / Q000276:immunology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000378:metabolism; D014376:Tuberculosis / Q000276:immunology*; D014774:Virulence
chemical_list: C510665:19K antigen, Mycobacterium tuberculosis; D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D051193:Toll-Like Receptors; C050016:lipoarabinomannan