title: Inhibitors of inosine monophosphate dehydrogenase: probes for antiviral drug discovery.
abstract: The role of inosine monophosphate dehydrogenase (IMPDH) at the metabolic branch point of de novo purine nucleotide biosynthesis makes this enzyme an attractive probe for the discovery of antiviral compounds. Introduction of unsaturation at the 2-position of IMP, the natural substrate for IMPDH, produces Michael acceptors at that position, which results in these compounds being inhibitors of IMPDH. Consistent with this mechanism-based molecular design, some of the parent nucleosides exhibited antiviral activity.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, Georgia, 30602, USA.
authors.forename: Sherry
authors.initials: S
authors.lastname: Story
authors.forename: Mukta
authors.initials: M
authors.lastname: Gupta
authors.forename: Eric
authors.initials: E
authors.lastname: Bonsu
authors.forename: Vasu
authors.initials: V
authors.lastname: Nair
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D013379:Substrate Specificity
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D007168:IMP Dehydrogenase