title: Dynamic chirality in donor-acceptor pretzelanes.
abstract: [Figure: see text]. A series of donor-acceptor pretzelanes has been synthesized, using self-assembly and template-directed protocols, and the dynamic processes that these pretzelanes undergo have been investigated in solution. These compounds exist as libraries of diastereoisomers as a result of their multiple stereoelements, which are dynamically interconverted by several different, in some cases competing, processes. Altering the structure of the pretzelanes changes the rates and mechanisms by which these diastereoisomers equilibrate. Additionally, inserting an element of fixed chirality allows the equilibrium to be biased, while maintaining the barrier to the equilibration processes. These results bode well for the future construction of molecular devices based on switchable diastereoisomerism involving metastable states.
authors.affiliation: California NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095-1569, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S A
authors.initials: SA
authors.lastname: Vignon
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: P A
authors.initials: PA
authors.lastname: Bonvallet
authors.forename: S I
authors.initials: SI
authors.lastname: Khan
authors.forename: K N
authors.initials: KN
authors.lastname: Houk
authors.forename: J F
authors.initials: JF
authors.lastname: Stoddart