Small molecules driving myotube fission.
In this issue of Chemistry & Biology, Duckmanton et al. have rigorously studied myotube fragmentation, or "cellularization," triggered by microtubule-disrupting agents. They convincingly demonstrate that cellularization remains integral to myogenic dedifferentiation, but is insufficient for reentry of the mononucleate progeny into the cell cycle.
Hines
John
J
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D020934:Ciliary Neurotrophic Factor / Q000494:pharmacology; D009025:Morpholines / Q000494:pharmacology; D018485:Muscle Fibers, Skeletal / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*; D011687:Purines / Q000494:pharmacology
D020934:Ciliary Neurotrophic Factor; D009025:Morpholines; D011687:Purines; C407365:myoseverin; C484369:2-(4-morpholinoanilino)-6-cyclohexylaminopurine