title: Asymmetric direct vinylogous Michael reaction of activated alkenes to nitroolefins catalyzed by modified cinchona alkaloids.
abstract: [reaction: see text] The first organocatalytic and asymmetric direct vinylogous Michael reaction that employs the electron-deficient vinyl malononitriles as the nucleophilic species has been reported. The novel transformations exhibit exclusive gamma-selectivity and high diastereo- and enantioselectivity in the addition to nitroolefins, which give the multifunctional products with two vicinal chiral centers.
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xue
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Wang
authors.forename: Ling-Feng
authors.initials: LF
authors.lastname: Cun
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.forename: Jin-Gen
authors.initials: JG
authors.lastname: Deng
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002930:Cinchona Alkaloids; D009574:Nitro Compounds; D014753:Vinyl Compounds