title: JAK-STAT pathway in cardiac ischemic stress.
abstract: In our quest for comprehensive protection of ischemic myocardium, both basic and clinical studies have lead us to examine signal transduction pathways involved in ischemia-reperfusion injury for potential therapeutic targets. In this review, we have highlighted the importance of the JAK-STAT pathway in modulating ischemia-reperfusion injury. The mechanisms linking glucose metabolism, angiotensin II, with JAK-STAT pathway in ischemic injury are explored in this review. Clearly, the studies discussed in this review provide rationale for the design and synthesis of selective blockers of JAK-STAT pathway as potential therapeutic adjuncts in protecting ischemic myocardium.
authors.affiliation: Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons 17-401, Columbia University, New York, NY 10032, USA.
authors.forename: Radha
authors.initials: R
authors.lastname: Ananthakrishnan
authors.forename: Kellie
authors.initials: K
authors.lastname: Hallam
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Ramasamy
mesh_terms: D000818:Animals; D005947:Glucose / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D053616:Janus Kinase 3; D017202:Myocardial Ischemia / Q000503:physiopathology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D050791:STAT Transcription Factors / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D050791:STAT Transcription Factors; D011505:Protein-Tyrosine Kinases; C507933:JAK3 protein, human; D053616:Janus Kinase 3; D005947:Glucose