Mechanism underlying the effect of myelopeptides on lymphocyte proliferation in vitro.
We studied the role of monocytes in the effect of myelopid and myelopeptides MP-1, MP-3, MP-5, and MP-6 on functional activity of peripheral blood lymphocytes in the reaction of blast transformation. Myelopeptides MP-1, MP-3, and MP-6 suppressed blast transformation of lymphocytes. The effect depended on the presence of monocytes in a cell culture.
Gavrilova
T V
TV
Analytical Laboratory, Institute for Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm.
Gein
S V
SV
Pogudina
T A
TA
Chereshnev
V A
VA
D000328:Adult; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000166:cytology* / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D009842:Oligopeptides / Q000276:immunology* / Q000494:pharmacology; D012588:Scintillation Counting
D007155:Immunologic Factors; D009842:Oligopeptides; C048617:myelopeptides