Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.
To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 degrees C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.
Fujii
Michihiko
M
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Japan.
Tanaka
Nanae
N
Miki
Kensuke
K
Hossain
Mohammad Nazir
MN
Endoh
Morio
M
Ayusawa
Dai
D
D000375:Aging / Q000235:genetics; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D004351:Drug Resistance / Q000235:genetics*; D008136:Longevity; D023421:Models, Animal; D018384:Oxidative Stress; D010269:Paraquat / Q000494:pharmacology*
D010269:Paraquat