title: Increased mutation frequencies in Escherichia coli isolates harboring extended-spectrum beta-lactamases.
abstract: Hypermutable (mutation frequency [f], > or = 4 x 10(-8)) Escherichia coli strains were more frequently found (43%) in a collection of 89 extended-spectrum beta-lactamase (ESBL)-producing isolates from different patients (77 pulsed-field gel electrophoresis clones, 12 ESBL types) than in non-ESBL E. coli (26%) strains (P = 0.03). Among urinary tract isolates, the frequency of hypermutation was 40% in ESBL versus 26% in non-ESBL isolates (P = 0.03).
authors.affiliation: Department of Microbiology, Ramón y Cajal University Hospital, Madrid, Spain.
authors.forename: María-Rosario
authors.initials: MR
authors.lastname: Baquero
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Galán
authors.forename: María
authors.initials: M
authors.lastname: del Carmen Turrientes
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Coque
authors.forename: José Luis
authors.initials: JL
authors.lastname: Martínez
authors.forename: Fernando
authors.initials: F
authors.lastname: Baquero
mesh_terms: D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics*; D006801:Humans; D009154:Mutation; D001618:beta-Lactamases / Q000032:analysis*
chemical_list: D001618:beta-Lactamases