title: The use of non-human primates in biological and medical research: evidence submitted by FRAME to the Academy of Medical Sciences/Medical Research Council/Royal Society/Wellcome Trust Working Group.
abstract: The Academy of Medical Sciences, the Medical Research Council, the Royal Society and the Wellcome Trust are undertaking a study into the use of non-human primates in biological and medical research. An independent working group of scientific experts, led by Sir David Weatherall, aims to produce a report summarising the findings of this study, early in 2006. The trends in primate research, and the nature and effects of recent and proposed changes in the global use of non-human primates in research, will be investigated. The associated ethical, welfare and regulatory issues, and the role and impact of the Three Rs principles of refinement, reduction and replacement will also be reviewed. As part of this study, a call for evidence was made. The evidence submitted by FRAME emphasised that the use of non-human primates for fundamental research or for regulatory testing still fails to take into account the fact that, although non-human primates are anatomically and physiologically similar to humans, they are not necessarily relevant models for studies on human disease or human physiology. FRAME continues to believe that we have a duty to ensure that these animals are not used without overwhelming evidence that they are the only suitable and relevant models for use in work of undeniable significance.
authors.affiliation: FRAME, 96-98 North Sherwood Street, Nottingham, NG1 4EE, UK. Nirmala@frame.org.uk
authors.forename: Nirmala
authors.initials: N
authors.lastname: Bhogal
authors.forename: Michelle
authors.initials: M
authors.lastname: Hudson
authors.forename: Michael
authors.initials: M
authors.lastname: Balls
authors.forename: Robert D
authors.initials: RD
authors.lastname: Combes
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D032761:Animal Experimentation / Q000941:ethics* / Q000706:statistics & numerical data; D000826:Animal Testing Alternatives; D000827:Animal Welfare; D000818:Animals; D030801:Animals, Genetically Modified; D001694:Biological Warfare; D035843:Biomedical Research / Q000941:ethics*; D015658:HIV Infections; D023321:Poliovirus Vaccines; D011323:Primates; D045169:Severe Acute Respiratory Syndrome; D014183:Transplantation, Heterologous
chemical_list: D023321:Poliovirus Vaccines