title: Quassinoids from the leaves of the Madagascan Simaroubaceae Samadera madagascariensis.
abstract: An investigation of the leaves of the Madagascan Simaroubaceae Samadera madagascariensis has yielded three C18 quassinoids, 5beta,6-dihydrosamaderine A, 2-chlorosamaderine A, and samaderolactone A, and a C19 quassinoid, 3,4beta-dihydrosamaderine C, together with the known quassinoids samaderine A, samaderine B, and cedronin. The compounds isolated displayed little or no anti-tumour activity.
authors.affiliation: School of Chemistry, University of KwaZulu-Natal, Howard College Campus, Durban 4041, South Africa.
authors.forename: Philip H
authors.initials: PH
authors.lastname: Coombes
authors.forename: Dashnie
authors.initials: D
authors.lastname: Naidoo
authors.forename: Dulcie A
authors.initials: DA
authors.lastname: Mulholland
authors.forename: Milijaona
authors.initials: M
authors.lastname: Randrianarivelojosia
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008270:Madagascar; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D036702:Quassins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029641:Simaroubaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036702:Quassins; C090500:cedronin; C432979:samaderin A; C432981:samaderin B