title: True tracers: comparing FDG with glucose and FLT with thymidine.
abstract: As PET metabolic imaging becomes routine in clinical practice, there is a tendency to make imaging and data analysis fast and simple, but interpretation of these pictures by visual inspection does not do justice to the power of PET technology. Tissue data and blood data can be analyzed mathematically to provide parametric images of the PET tracer's biochemistry in terms of a transport parameter and a metabolic flux. The methods for parametric imaging with (11)C tracers of glucose and thymidine have been validated, but the short half-life of this radionuclide and the rapid metabolism of these labeled substrates to [(11)C]CO(2) have led investigators to develop (18)F analogs. While (18)F substitution at critical positions in the natural substrate can block metabolism, it has other effects on the transport and metabolism of the analog tracer. The fidelity with which analog tracers mimic tracers of the authentic substrate is critically evaluated for [(18)F]-2-fluoro-2-deoxyglucose and [(18)F]-3'-fluoro-3'-deoxythymidine.
authors.affiliation: Department of Radiology, University of Washington, Seattle, 98195-6004, USA.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Krohn
authors.forename: David A
authors.initials: DA
authors.lastname: Mankoff
authors.forename: Mark
authors.initials: M
authors.lastname: Muzi
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: Link
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Spence
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D001931:Brain Mapping / Q000379:methods; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D015224:Dideoxynucleosides / Q000493:pharmacokinetics*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013936:Thymidine / Q000378:metabolism*
chemical_list: D015224:Dideoxynucleosides; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose; C002854:alovudine; D013936:Thymidine