Effect of gravity on liquid plug transport through an airway bifurcation model.
Many medical therapies require liquid plugs to be instilled into and delivered throughout the pulmonary airways. Improving these treatments requires a better understanding of how liquid distributes throughout these airways. In this study, gravitational and surface mechanisms determining the distribution of instilled liquids are examined experimentally using a bench-top model of a symmetrically bifurcating airway. A liquid plug was instilled into the parent tube and driven through the bifurcation by a syringe pump. The effect of gravity was adjusted by changing the roll angle (phi) and pitch angle (gamma) of the bifurcation (phi = gamma =0 deg was isogravitational). Phi determines the relative gravitational orientation of the two daughter tubes: when phi not equal to 0 deg, one daughter tube was lower (gravitationally favored) compared to the other. Gamma determines the component of gravity acting along the axial direction of the parent tube: when gamma not equal to 0 deg, a nonzero component of gravity acts along the axial direction of the parent tube. A splitting ratio Rs, is defined as the ratio of the liquid volume in the upper daughter to the lower just after plug splitting. We measured the splitting ratio, Rs, as a function of: the parent-tube capillary number (Cap); the Bond number (Bo); phi; gamma; and the presence of pre-existing plugs initially blocking either daughter tube. A critical capillary number (Cac) was found to exist below which no liquid entered the upper daughter (Rs = 0), and above which Rs increased and leveled off with Cap. Cac increased while Rs decreased with increasing phi, gamma, and Bo for blocked and unblocked cases at a given Cap > Ca,. Compared to the nonblockage cases, Rs decreased (increased) at a given Cap while Cac increased (decreased) with an upper (lower) liquid blockage. More liquid entered the unblocked daughter with a blockage in one daughter tube, and this effect was larger with larger gravity effect. A simple theoretical model that predicts Rs and Cac is in qualitative agreement with the experiments over a wide range of parameters.
Zheng
Y
Y
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Anderson
J C
JC
Suresh
V
V
Grotberg
J B
JB
D001692:Biological Transport / Q000502:physiology; D001826:Body Fluids / Q000502:physiology*; D001992:Bronchoalveolar Lavage Fluid; D003198:Computer Simulation; D006112:Gravitation; D006801:Humans; D008168:Lung / Q000502:physiology*; D044085:Microfluidics / Q000379:methods*; D008954:Models, Biological; D011663:Pulmonary Surfactants / Q000378:metabolism*; D015656:Respiratory Mechanics / Q000502:physiology*
D011663:Pulmonary Surfactants