Substituted phenanthrenes with basic amino side chains: a new series of anti-breast cancer agents.
In the course of our search for new anti-breast cancer agents, substituted phenanthrenes with basic amino side chains were synthesized and some of them showed remarkable antiproliferative activity against ER +ve MCF-7 cell line with IC(50) in the range of 3.53-22.25 microM. One of the compounds 15 ca showed anti-breast cancer activity in 7,12-dimethylbenz[a]anthracene (DMBA) induced hormone-dependent mammary tumor in rat and the activity was comparable to that shown by tamoxifen.
Shagufta
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, UP, India.
Srivastava
Ajay Kumar
AK
Sharma
Ramesh
R
Mishra
Rajeev
R
Balapure
Anil Kumar
AK
Murthy
Puvvada S R
PS
Panda
Gautam
G
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D020128:Inhibitory Concentration 50; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008956:Models, Chemical; D010616:Phenanthrenes / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D013629:Tamoxifen / Q000494:pharmacology; D013997:Time Factors
D000596:Amino Acids; D000970:Antineoplastic Agents; D010616:Phenanthrenes; D013629:Tamoxifen; D015127:9,10-Dimethyl-1,2-benzanthracene