Animal models in oral cancer research.
Biologically and clinically relevant animal models are essential in investigation of the progression of diseases and the elaboration of diagnostic or therapeutic protocols. The several rodent models used for in vivo evaluation for oral cancer employ chemical, transplantation and genetic (knockout and transgenic) induction methods. These models are described together with their advantages and disadvantages. Their optimization and application in future research may improve the early detection and treatment of oral cancer.
Mognetti
B
B
Pharmacology Unit, Department of Biological and Clinical Science, University of Turin, Ospedale San Luigi, Orbassano (TO), Italy.
Di Carlo
F
F
Berta
G N
GN
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000209:etiology / Q000235:genetics; D003043:Cocarcinogenesis; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic