title: Conversion of a carboxylesterase into a triacylglycerol lipase by a random mutation.
authors.affiliation: Institute of Catalysis, CSIC, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Reyes-Duarte
authors.forename: Julio
authors.initials: J
authors.lastname: Polaina
authors.forename: Nieves
authors.initials: N
authors.lastname: López-Cortés
authors.forename: Miguel
authors.initials: M
authors.lastname: Alcalde
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Plou
authors.forename: Kieran
authors.initials: K
authors.lastname: Elborough
authors.forename: Antonio
authors.initials: A
authors.lastname: Ballesteros
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: Timmis
authors.forename: Peter N
authors.initials: PN
authors.lastname: Golyshin
authors.forename: Manuel
authors.initials: M
authors.lastname: Ferrer
mesh_terms: D043182:Carboxylesterase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000235:genetics*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000235:genetics*; D016296:Mutagenesis; D009154:Mutation; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D043182:Carboxylesterase; D008049:Lipase