title: Innate control of adaptive immunity via remodeling of lymph node feed arteriole.
abstract: The adaptive immune system relies on rare cognate lymphocytes to detect pathogen-derived antigens. Naïve lymphocytes recirculate through secondary lymphoid organs in search of cognate antigen. Here, we show that the naïve-lymphocyte recirculation pattern is controlled at the level of innate immune recognition, independent of antigen-specific stimulation. We demonstrate that inflammation-induced lymphocyte recruitment to the lymph node is mediated by the remodeling of the primary feed arteriole, and that its physiological role is to increase the efficiency of screening for rare antigen-specific lymphocytes. Our data reveal a mechanism of innate control of adaptive immunity: by increasing the pool of naïve lymphocytes for detection of foreign antigens via regulation of vascular input to the local lymph node.
authors.affiliation: Section of Immunobiology, John B. Pierce Laboratory and Department of Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Soderberg
authors.forename: Geoffrey W
authors.initials: GW
authors.lastname: Payne
authors.forename: Ayuko
authors.initials: A
authors.lastname: Sato
authors.forename: Ruslan
authors.initials: R
authors.lastname: Medzhitov
authors.forename: Steven S
authors.initials: SS
authors.lastname: Segal
authors.forename: Akiko
authors.initials: A
authors.lastname: Iwasaki
mesh_terms: D000818:Animals; D001160:Arterioles / Q000473:pathology*; D005260:Female; D006984:Hypertrophy; D007113:Immunity, Innate; D007249:Inflammation / Q000473:pathology; D008198:Lymph Nodes / Q000098:blood supply / Q000473:pathology*; D042601:Lymphatic Vessels / Q000473:pathology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018417:Th1 Cells / Q000276:immunology