Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.
A series of N3, 5-Anhydro-4-(beta-D-ribofuranosyl)-8-azapurin-2-ones were prepared in multistep reactions from uridine as potential anti-hepatitis C virus (HCV) agents. The synthetic details as well as biological evaluations are discussed.
Hassan
Abdalla E A
AE
Department of Chemical Sciences, Pharmasset, Inc., Tucker, Georgia, USA.
Wang
Peiyuan
P
McBrayer
Tamara R
TR
Tharnish
Phillip M
PM
Stuyver
Lieven J
LJ
Schinazi
Raymond F
RF
Otto
Michael J
MJ
Watanabe
Kyoichi A
KA
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002474:Cell-Free System; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D016174:Hepacivirus / Q000378:metabolism*; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D008956:Models, Chemical; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012313:RNA / Q000737:chemistry; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry; D012263:Ribonucleosides; D014529:Uridine / Q000737:chemistry
D000998:Antiviral Agents; D011684:Purine Nucleosides; D012263:Ribonucleosides; D012313:RNA; D012324:RNA-Dependent RNA Polymerase; D014529:Uridine