Metals and oxidative stress in patients with Parkinson's disease.
Twenty-six metals and the oxidative status in 71 patients affected by Parkinson's disease and 44 healthy individuals were compared in order to identify potential biomarkers of the disease. In the patients, the following significant imbalances were found (p < or = 0.05): i) in serum, an increment of Ca, Mg, Ni, Si and V, and a decrement of Cd, Co, Fe, Li, Sn, Zn and Zr; ii) in blood, raised levels of Co, Li, Ni and Si and decreased of Al, Be, Ca, Cd, Fe, Mg, Mo, Sn, Zn and Zr; iii) increased formation of oxidant species and lowered anti-oxidant capacity (p < or = 0.001 for both). Barium, Bi, Cr, Cu, Hg, Mn, Pb, Sb, Sr, Tl and W did not change with the disease. The best discriminating variables between patients and controls were Cd, Co, Fe, Ni and Si in serum (91.2% of cases correctly classified), and Al, Cd, Co, Fe, Mo and Si in blood (98.2% of cases properly classified).
Forte
Giovanni
G
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
Alimonti
Alessandro
A
Pino
Anna
A
Stanzione
Paolo
P
Brescianini
Sonia
S
Brusa
Livia
L
Sancesario
Giuseppe
G
Violante
Nicola
N
Bocca
Beatrice
B
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000009:adverse effects / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D012825:Silicon / Q000097:blood
D000978:Antiparkinson Agents; D008670:Metals; D012825:Silicon