Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol.
The planned MADIT-CRT trial is designed to determine if CRT-D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I-II) and non-ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF<or=0.30), and prolonged intraventricular conduction (QRS duration>or=130 ms).
Moss
Arthur J
AJ
Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. heartajm@heart.rochester.edu
Brown
Mary W
MW
Cannom
David S
DS
Daubert
James P
JP
Estes
Mark
M
Foster
Elyse
E
Greenberg
Henry M
HM
Hall
W Jackson
WJ
Higgins
Steven L
SL
Klein
Helmut
H
Pfeffer
Mark
M
Wilber
David
D
Zareba
Wojciech
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial / Q000706:statistics & numerical data*; D015897:Comorbidity; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000628:therapy*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology / Q000628:therapy*