[Correlation of serum Bio-intact PTH (1-84) and parathyroid gland size in hemodialysed patients].
Bio-intact parathyroid hormone (Bio-PTH) assay, which measures exclusively intact PTH (1-84) molecule, provides a better assay for estimating parathyroid function in hemodialysis (HD) patients, whereas intact PTH (I-PTH) assay cross-react with PTH (7-84) as well as PTH (1-84). We have found that PTH (7-84) accumulated into serum of hemodialysis patients due probably to its impaired excretion into urine. We have reported that parathyroid gland size is one of major predictor for vitamin D responsiveness in secondary hyperparathyroidism. Therefore, we investigated whether serum Bio-PTH, in comparison with serum I-PTH, may provide a relevant assay to estimate parathyroid function as evidence by its correlation with parathyroid gland size on ultrasound examination.
Inaba
Masaaki
M
Department of Metabolism, Endocrinilogy and Molecular Medicine, Osaka City University Graduate School of Medicine.
Imanishi
Yasuo
Y
Ueda
Misako
M
Cho
Hidenori
H
Tahara
Hideki
H
Ishimura
Eiji
E
Nishizawa
Yoshiki
Y
Yamakawa
Tomoyuki
T
Okuno
Senji
S
D015415:Biomarkers / Q000097:blood; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis* / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010280:Parathyroid Glands / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000009:adverse effects*; D014463:Ultrasonography; D014807:Vitamin D / Q000378:metabolism
D015415:Biomarkers; D010281:Parathyroid Hormone; D010446:Peptide Fragments; C414937:parathyroid hormone (7-84); D014807:Vitamin D