title: Color vision and contrast sensitivity in epilepsy patients treated with initial tiagabine monotherapy.
abstract: The purpose of the study was to determine whether the use of a GABAergic antiepileptic drug (AED), tiagabine, affects color vision and contrast sensitivity. Twenty newly diagnosed patients with partial epilepsy (aged 19-72 years), receiving tiagabine as their initial monotherapy for 5-41 months were examined. Color vision was examined with the Standard Pseudoisochromatic Plates 2 (SPP2), with the Farnsworth-Munsell 100 Hue Test (FM100) and with the Color Vision Meter 712 (CVM) anomaloscope. Contrast sensitivity was measured with the Pelli-Robson letter chart. Three patients excluded from the color vision evaluation for congenital red-green color vision defects. Seven out of 17 patients (41%) had acquired color vision deficit examined with the FM100. The CVM anomaloscope revealed minor defects in two patients. Contrast sensitivity function was within normal ranges. The present study suggests that AED therapy with tiagabine, like with other established and newer AEDs may interfere with color perception.
authors.affiliation: Department of Ophthalmology, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kuopio, Finland; Department of Ophthalmology, University of Kuopio, Kuopio, Finland. Iiris.Sorri@uku.fi
authors.forename: Iiris
authors.initials: I
authors.lastname: Sorri
authors.forename: Reetta
authors.initials: R
authors.lastname: Kälviäinen
authors.forename: Maija
authors.initials: M
authors.lastname: Mäntyjärvi
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D003118:Color Perception / Q000187:drug effects*; D015350:Contrast Sensitivity / Q000187:drug effects*; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009557:Nipecotic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D000078308:Tiagabine; D014787:Vision Tests
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine