Cholesterol and apoe: a target for Alzheimer's disease therapeutics.
Alzheimer's disease (AD) is a debilitating disease that affects many people. In order to reduce the number of people diagnosed with this disease, drug strategies need to be implemented that target early steps in disease pathogenesis. Elevated cholesterol levels and presence of the apolipoprotein E eta4 allele increase AD risk. How these two factors may contribute to AD pathogenesis and some therapeutic strategies for alleviating AD risk will be discussed.
Fenili
Daniela
D
Centre for Research in Neurodegenerative Diseases and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
McLaurin
Joanne
J
D000544:Alzheimer Disease / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans
D016564:Amyloid beta-Protein Precursor; D000924:Anticholesteremic Agents; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002784:Cholesterol