[Suitable examination intervals for hemodialysis patients with secondary hyperparathyroidism treated with maxacalcitol].
Five patients with secondary hyperparathyroidism undergoing chronic hemodialysis, whose level of intact-PTH was less than 500 pg/mL, were treated with maxacalcitol for 16 weeks. The levels of serum intact-PTH, corrected calcium, phosphorous, ALP and BAP were measured every 2 weeks, and we investigated the suitable examination intervals to evaluate parathyroid function in these patients. Intact-PTH decreased significantly after 6 weeks, and thereafter corrected serum calcium level increased. From these results it is necessary to put emphasis to the time before 8 weeks in the measurement of intact-PTH, and on the other hand, after 8 weeks in the measurement of corrected serum calcium. ALP showed no significant change during the administration period. As a bone metabolic marker, BAP is more useful, and its measurement is enough for every 2 months. In conclusion, suitable examination intervals during the period of maxacalcitol treatment might not be adapted to the recommendation in the K/DOQI guideline 8B.2.
Yamada
Yoshihiro
Y
Dialysis Section, Toyoshina Red Cross Hospital.
Kumafuji
Masahiro
M
Sodeyama
Takanori
T
Suzawa
Taichi
T
Momose
Mitsuo
M
Tokoo
Masuo
M
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D017410:Practice Guidelines as Topic; D006435:Renal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors
D015415:Biomarkers; D010281:Parathyroid Hormone; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002117:Calcitriol; C051883:maxacalcitol; D002118:Calcium