title: Biotransformation of citrus aromatics nootkatone and valencene by microorganisms.
abstract: Biotransformations of the sesquiterpene ketone nootkatone from the crude drug Alpiniae Fructus and grapefruit oil, and the sesquiterpene hydrocarbon valencene from Valencia orange oil were carried out with microorganisms such as Aspergillus niger, Botryosphaeria dothidea, and Fusarium culmorum to afford structurally interesting metabolites. Their stereostructures were established by a combination of high-resolution NMR spectral and X-ray crystallographic analysis and chemical reaction. Metabolic pathways of compounds and by A. niger are proposed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Furusawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Noma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D002957:Citrus / Q000737:chemistry*; D005658:Fungi / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D000081223:Polycyclic Sesquiterpenes; D011817:Rabbits; D012717:Sesquiterpenes / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C506706:valencene; C050302:nootkatone