Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus.
2'3'-Dideoxy furanopyrimidines were shown to display anti-HCMV activity via a non-nucleoside mechanism. Further studies into highly modified sugar derivatives led to the preparation of N-and O-alkylated C10 furanopyrimidine analogues, and this work is described herein. These compounds were tested against HCMV strains, and the first case of submicromolar activity was observed.
Kelleher
M R
MR
Welsh School of Pharmacy, Redwood Building, King Edward VII Ave., CF10 3XF, Cardiff, UK. kellehermr@cf.ac.uk
McGuigan
C
C
Andrei
G
G
Snoeck
R
R
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003587:Cytomegalovirus / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005663:Furans / Q000737:chemistry*; D006801:Humans; D008168:Lung / Q000821:virology; D008956:Models, Chemical; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*
D000998:Antiviral Agents; D005663:Furans; D011743:Pyrimidines