Synthesis of isoxazoles via electrophilic cyclization.
[reaction: see text] A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or PhSeBr.
Waldo
Jesse P
JP
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Larock
Richard C
RC
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis*; D007555:Isoxazoles / Q000138:chemical synthesis*; D015394:Molecular Structure
D000480:Alkynes; D006846:Hydrocarbons, Halogenated; D007555:Isoxazoles