title: Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate.
abstract: Optical tomography has been used to reconstruct three-dimensional images of the entire neonatal head during motor evoked responses. Data were successfully acquired during passive movement of each arm on four out of six infants examined, from which eight sets of bilateral images of hemodynamic parameters were reconstructed. Six out of the eight images showed the largest change in total hemoglobin in the region of the contralateral motor cortex. The mean distance between the peak response in the image and the estimated position of the contralateral motor cortex was 10.8 mm. These results suggest that optical tomography may provide an appropriate technique for non-invasive cot-side imaging of brain function.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London WC1E 6BT, UK. agibson@medphys.ucl.ac.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Gibson
authors.forename: T
authors.initials: T
authors.lastname: Austin
authors.forename: N L
authors.initials: NL
authors.lastname: Everdell
authors.forename: M
authors.initials: M
authors.lastname: Schweiger
authors.forename: S R
authors.initials: SR
authors.lastname: Arridge
authors.forename: J H
authors.initials: JH
authors.lastname: Meek
authors.forename: J S
authors.initials: JS
authors.lastname: Wyatt
authors.forename: D T
authors.initials: DT
authors.lastname: Delpy
authors.forename: J C
authors.initials: JC
authors.lastname: Hebden
mesh_terms: D000465:Algorithms; D001132:Arm / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D014054:Tomography / Q000379:methods*
chemical_list: D006454:Hemoglobins; D010100:Oxygen