title: [Contribution of stem cells to renal repair after ischemia/reperfusion].
abstract: Repair of inflammatory and/or ischemic renal injury involves endothelial, mesangial and epithelial regeneration. These structures may be rebuilt by resident progenitor cells and bone marrow-derived stem cells. Resident progenitor cells in adult kidney have not yet been conclusively identified. They are likely to be slowly cycling cells located mainly in the outer medulla and renal papilla. In glomerulonephritis with mesangiolysis, mesangial regenera- tion involves progenitor cells migrating from the juxtaglomerular apparatus and also bone marrow-derived cells. In acute ischemic renal failure, epithelial regeneration of proximal tubules results from the migration, proliferation and differentiation of resident progenitor cells; bone marrow-derived cells may play an accessory role. Molecular mechanisms underlying these repair processes could be targets for new therapeutic approaches.
authors.affiliation: INSERM U 702 et Service d'Explorations Fonctionnelles Multidisciplinaires, Hôpital Tenon-- 4, rue de la Chine - 75020 Paris.
authors.forename: Laurent
authors.initials: L
authors.lastname: Baud
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Haymann
authors.forename: Agnès
authors.initials: A
authors.lastname: Bellocq
authors.forename: Bruno
authors.initials: B
authors.lastname: Fouqueray
mesh_terms: D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000166:cytology / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology; D015427:Reperfusion Injury / Q000628:therapy*; D013234:Stem Cells / Q000502:physiology*