title: Relative stability of quadruplexes containing different number of G-tetrads.
abstract: The aim of this work is to compare the physicochemical properties of three oligonucleotidic sequences, d(TGGGT), d(TGGGGT) and d(TGGGGGT), which assemble to form quadruplex structures with the same molecularity, but containing three, four, and five G-quartets, respectively. The addition of one or two G-tetrads greatly increases both the enthalpy and Tm values of the quadruplex dissociation.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano (SA), Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Petraccone
authors.forename: Eva
authors.initials: E
authors.lastname: Erra
authors.forename: Ida
authors.initials: I
authors.lastname: Duro
authors.forename: Veronica
authors.initials: V
authors.lastname: Esposito
authors.forename: Antonio
authors.initials: A
authors.lastname: Randazzo
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
authors.forename: Carlo Andrea
authors.initials: CA
authors.lastname: Mattia
authors.forename: Guido
authors.initials: G
authors.lastname: Barone
authors.forename: Concetta
authors.initials: C
authors.lastname: Giancola
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006358:Hot Temperature; D008967:Molecular Biology / Q000379:methods*; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D004247:DNA