Halogenated helianane derivatives from the sponge Spirastrella hartmani.
Two new halogenated derivatives (1 and 2) of helianane (3) were isolated from the 2-propanol extract of the sponge Spirastrella hartmani. The structures of the new derivatives were determined on the basis of detailed spectroscopic analysis, including (+)-HREIMS and 1D and 2D NMR. Compound 1 showed in vitro cytotoxicity against the human tumor cell lines A549, HT29, and MDA-MB-231.
Martín
María Jesús
MJ
Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770 Colmenar Viejo, Madrid, Spain.
Berrué
Fabrice
F
Amade
Philippe
P
Fernández
Rogelio
R
Francesch
Andrés
A
Reyes
Fernando
F
Cuevas
Carmen
C
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C505682:helianane