[Clinical significance of PTH (1-84) and PTH (7-84) in patients with predialysis chronic renal failure in relation to bone metabolism markers].
Serum levels of parathyroid hormone (PTH) in predialysis patients with chronic renal failure (CRF) were measured using both the "intact PTH" and "bio PTH" assays, and serum levels of PTH (7-84) were assessed by subtracting bio PTH from intact PTH. The PTH values measured by the two assays were strongly correlated, and were also significantly positively correlated with both bone formation and resorption markers. PTH (7-84) was significantly positively correlated with both the intact PTH and bio PTH, and was also significantly positively correlated with the bone metabolism markers. There is no significant relationship between bio PTH/PTH (7-84) ratio and bone metabolism markers. In conclusion, bio PTH and intact PTH assays have similar clinical significance in predialysis CRF patients. The PTH (7-84) and even the ration of bio-PTH/PTH (7-84) have little specific clinical effect on bone metabolism.
Tsuchida
Takao
T
Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine.
Ishimura
Eiji
E
Hirowatari
Kaname
K
Matsumoto
Naoki
N
Jono
Shuichi
S
Miki
Takami
T
Inaba
Masaaki
M
Nishizawa
Yoshiki
Y
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000175:diagnosis* / Q000209:etiology* / Q000378:metabolism; D001862:Bone Resorption; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D003956:Dialysis; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood
D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C414937:parathyroid hormone (7-84); D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase