title: New trends in synthesis of pyrazole nucleosides as new antimetabolites.
abstract: Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.
authors.affiliation: Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt.
authors.forename: Galal H
authors.initials: GH
authors.lastname: Elgemeie
authors.forename: Wafaa A
authors.initials: WA
authors.lastname: Zaghary
authors.forename: Kamelia M
authors.initials: KM
authors.lastname: Amin
authors.forename: Tamer M
authors.initials: TM
authors.lastname: Nasr
mesh_terms: D000577:Amides; D000963:Antimetabolites / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004267:DNA Viruses; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D012266:Ribose; D013329:Structure-Activity Relationship; D014777:Virus Diseases / Q000188:drug therapy*
chemical_list: D000577:Amides; D000963:Antimetabolites; D000998:Antiviral Agents; D011720:Pyrazoles; D012263:Ribonucleosides; C031280:pyrazole; C002997:pyrazofurin; D012266:Ribose