p-p70S6K (Thr 389) Expression in nodular sclerosing hodgkin's disease as evidence for receptor tyrosine kinase signaling.
Platelet-derived growth factor receptor-alpha (PDGFR-alpha) expression in the Hodgkin/Reed-Sternberg cells of nodular sclerosing Hodgkin's disease has been demonstrated in 2 studies. Additional receptor tyrosine kinases have also now been documented. This communication reports the correlative expression in nodular sclerosing Hodgkin's disease of activated (phosphorylated) p70S6K, one of the putative downstream effectors common to receptor tyrosine kinase signaling.
Brown
Robert E
RE
Anatomic Pathology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822-0131, USA. rebrown@geisinger.edu
Kamal
Nazmi R
NR
D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D010766:Phosphorylation; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000378:metabolism*; D012598:Sclerosis; D015398:Signal Transduction
D020794:Receptor Protein-Tyrosine Kinases; D038762:Ribosomal Protein S6 Kinases, 70-kDa