Reduced immunoreactivities of a vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptor (VPAC1 receptor) in the cerebral cortex, hippocampal region, and amygdala of aged rats.
In this study, we examined expressional changes of VPAC1 receptor in aged rat brains using an immunohistochemical approach and found that its immunoreactivities are significantly reduced in the cerebral cortex, hippocampal region, and amygdala of aged rats. These results suggest that this reduction could underlie aging-associated memory/learning deficits and several other age-induced functional changes in these areas. However, the functional consequences of these down-regulations require further elucidation.
Joo
Kyeung Min
KM
Department of Anatomy, Seoul National University College of Medicine, 28 Yeongeon-dong, Jongno-gu, Seoul 110-799, Korea.
Chung
Yoon Hee
YH
Lim
Heon-chang
HC
Lee
Kyung Hoon
KH
Cha
Choong Ik
CI
D000375:Aging / Q000378:metabolism*; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I / Q000378:metabolism*; D014018:Tissue Distribution; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I; D014660:Vasoactive Intestinal Peptide