title: Conditions of primary excessive daytime sleepiness.
abstract: Excessive daytime somnolence is a prevalent problem in medical practice and in society. It exacts a great toll in quality of life, personal and public safety, and productivity. The causes of EDS are myriad, and careful evaluation is needed to determine the cause in each case. Although much progress has been made in discovering the pathophysiology of narcolepsy, much more remains to be understood, and far less is known about other primary conditions of EDS. Several methods have been developed to assess EDS, although each of them has limitations. Treatment is available for the great majority of cases.
authors.affiliation: Stanford Sleep Disorders Center, Sleep Medicine Division, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. MajorSleep@yahoo.com
authors.forename: Jed E
authors.initials: JE
authors.lastname: Black
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Brooks
authors.forename: Seiji
authors.initials: S
authors.lastname: Nishino
mesh_terms: D001334:Automobile Driving; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D002490:Central Nervous System / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006680:HLA Antigens / Q000502:physiology; D006212:Hallucinations / Q000175:diagnosis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid; D000077408:Modafinil; D009290:Narcolepsy / Q000175:diagnosis / Q000503:physiopathology; D009479:Neuropeptides / Q000134:cerebrospinal fluid; D000068797:Orexins; D017286:Polysomnography; D012307:Risk Factors; D020188:Sleep Paralysis / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D006680:HLA Antigens; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D000077408:Modafinil