title: Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case.
abstract: In following up a patient with non-Hodgkin's lymphoma, we encountered a case of pulmonary pleomorphic carcinoma with mediastinal direct invasion. A 65-year-old man with hemoptysis was found to have an abnormal shadow in the right upper lung field. A 6.4 x 4.8-cm tumor adjacent to the upper mediastinum occupied the right anterior segment of the upper lobe (S3) and invaded the superior vena cava (SVC). The serum level of neuron-specific enolase was elevated to 11.9 ng/ml. A specimen from a transbronchial lung biopsy of the right B3b bronchus revealed giant tumor cells. A right upper lobectomy with SVC reconstruction was performed. The resected tumor was diagnosed as a pulmonary pleomorphic carcinoma with a large component of giant and spindle cells, and it is considered to be a rare histologic type.
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakajima
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iizasa
authors.forename: Akira
authors.initials: A
authors.lastname: Iyoda
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yasufuku
authors.forename: Masako
authors.initials: M
authors.lastname: Chiyo
authors.forename: Takashi
authors.initials: T
authors.lastname: Anayama
authors.forename: Hidemi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ohwada
authors.forename: Takehiko
authors.initials: T
authors.lastname: Fujisawa
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018286:Carcinoma, Giant Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000175:diagnosis; D019043:Vascular Neoplasms / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D014683:Vena Cava, Superior