[The effect of sphyngolipids on the mechanical properties of epidermis and its permeability for water].
The effect of water, glycerol, Lipotec(s.a), a hydrophobic sphyngolipid complex, and a liposome water emulsion (prepared from pig brain glycosphyngolipids) on the skin elasticity, evaluated from its resonance frequency, was investigated. It was shown that moistening of skin with water leads to swelling of epidermis cells, which is accompanied by an increase in cellular membrane tension and elasticity growth. This shows up in a statistically authentic (alpha = 0.0025, T-test) growth of skin resonance frequency (on the average by 48.5 +/- 13% in 3 min). Skin moistening by a glycosphyngolipid liposome water emulsion causes a more intensive swelling of epidermis (skin resonance frequency in three minutes increases on the average by 75.8 +/- 22.1%, alpha = 0.0059). No swelling of epidermis was observed if skin was moistened by glycerol or by hydrophobic sphyngolipid complex Lipotec(s.a). It was concluded that pig brain glycosphyngolipid molecules having volumetric negatively charged polar heads are built into lamellar structures of the skin lipid barrier and increase its hydrophilicity and permeability for water.
Timofeev
A B
AB
Mukhtarov
E I
EI
Mukhtarova
S E
SE
Timofeev
G A
GA
D000818:Animals; D004817:Epidermis / Q000502:physiology*; D006028:Glycosphingolipids / Q000494:pharmacology*; D006801:Humans; D010539:Permeability / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects*; D013552:Swine; D014867:Water / Q000378:metabolism*
D006028:Glycosphingolipids; D014867:Water