A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.
Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
Chambers
Robert J
RJ
Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. Robert.J.Chambers@pfizer.com
Abrams
Kristin
K
Castleberry
Tessa A
TA
Cheng
John B
JB
Fisher
Douglas A
DA
Kamath
Ajith V
AV
Marfat
Anthony
A
Nettleton
David O
DO
Pillar
Joann D
JD
Salter
Eben D
ED
Sheils
Alissa L
AL
Shirley
John T
JT
Turner
Claudia R
CR
Umland
John P
JP
Lam
Kelvin T
KT
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000502:physiology*; D002633:Chemotaxis / Q000187:drug effects; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004804:Eosinophils / Q000187:drug effects / Q000502:physiology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D009536:Niacinamide / Q000037:antagonists & inhibitors*; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020889:Rolipram / Q000737:chemistry / Q000494:pharmacology
D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors; D009536:Niacinamide; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram