Growth and growth hormone in children born small for gestational age.
Although most children born small for gestational age catch up in growth by age 2 y, up to 14% remain more than 2 standard deviations below the mean for height. Recombinant growth hormone is approved by the US Food and Drug Administration and by the European Agency for Evaluation of Medicinal Products for the treatment of children born small for gestational age who fail to manifest catch-up growth by 2 y or 4 y, respectively.


CONCLUSIONS
We conclude from clinical studies that growth hormone therapy can induce catch-up growth in these children.
Rapaport
Robert
R
Division of Pediatric Endocrinology and Diabetes, Mount Sinai School of Medicine, New York, NY 10029-5216, USA. robert.rapaport@msnyuhealth.org
Tuvemo
Torsten
T
D001827:Body Height / Q000187:drug effects*; D002657:Child Development / Q000187:drug effects; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I