Association of NOD2/CARD15 mutations with previous surgical procedures in Crohn's disease.
OBJECTIVE
The aim of this study is to assess the importance of NOD2/CARD15 gene mutations as prognostic factors for surgical indications in Crohn's disease. PATIENTS AND EXPERIMENTAL DESIGN: A total of 165 Crohn s disease patients were studied, considering previous surgery related to Crohn's disease. We analyzed for previous surgery in global procedures as well as separately for the two main surgical indications: ileal resection and fistula treatment. The need for appendectomy was also studied. All patients were genotyped for the three CARD15 mutations, and association studies were developed using Chi-square statistics and Fisher's exact test whenever appropriate.


RESULTS
Carriers of the G908R or 1007fs mutation needed surgery more frequently, both for ileal resection and fistula repair. In contrast, appendectomy was not associated with CARD15 mutations.


CONCLUSIONS
As previously reported in this population, the R702W mutation does influence parameters of disease or need of surgery. The need for Crohn's disease-related surgery is higher in carriers of the G908R or 1007fs CARD15 mutation in the Galician population. Nevertheless, the frequency of these mutations does not allow their use to predict the course of disease.
Barreiro
M
M
Department of Gastroenterology, Hospital Clínico Universitario de Santiago de Compostela, Spain. manubarreiro@hotmail.com
Núñez
C
C
Domínguez-Muñoz
J E
JE
Lorenzo
A
A
Barreiro
F
F
Potel
J
J
Peña
A S
AS
D000293:Adolescent; D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000235:genetics* / Q000601:surgery*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D053473:Nod2 Signaling Adaptor Protein; D011379:Prognosis
D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein