[Infections associated to severe thrombotic events and antiphospholipid antibodies].
The authors present 2 cases of infections in which the presence of antiphospholipid antibodies (APL), anticardiolipin and anti-beta2-GP1, was associated to the occurrence of significant thrombotic events: 1) a 55-year-old male patient whose serology (indirect immunofluorescence) revealed Coxiella burnetii infection (phase 2 antigens) with IgG at 1,600 and IgM at 50 (significant titer: IgG>or=200 and IgM>or=50); 2) and a 20-year-old male patient with a CMV infection confirmed by serology (IgG: 44 U/ml, significant threshold 6, IgM: 2.1 U/ml, significant threshold 0.9).
Vidal
M
M
Service de maladies infectieuses et tropicales, Hôtel-Dieu, CHU de Clermont-Ferrand, boulevard Léon-Malfreyt, 63000 Clermont-Ferrand, France.
Corbin
V
V
Chanet
V
V
Ruivard
M
M
Gourdon
F
F
Laurichesse
H
H
Beytout
J
J
Lesens
O
O
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000097:blood* / Q000209:etiology*; D012720:Severity of Illness Index; D013927:Thrombosis / Q000097:blood* / Q000150:complications*
D017152:Antibodies, Antiphospholipid