A new notch in the HIF belt: how hypoxia impacts differentiation.
In the current issue of Developmental Cell, work by Gustafsson and coworkers demonstrates that hypoxia synergizes with Notch to inhibit differentiation of myogenic and neural precursor cells. This effect requires a newly described interaction between the transcriptionally active form of HIF-1alpha and the intracellular domain of Notch.
Cejudo-Martin
Pilar
P
Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Johnson
Randall S
RS
D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D004151:Dipeptides / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051880:Receptors, Notch / Q000187:drug effects / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D002219:Carbamates; D004151:Dipeptides; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C410009:L 685458; D051880:Receptors, Notch