[Local tolerability of two preparations with eucalyptus oil and pine-needle oil].
The objective of this open-label, single-centre study was to assess the tolerability of two locally applicable eucalyptus oil and pine-needle oil preparations using patch testing as an accepted and standardised method.


METHODS
Two eucalyptus oil and pine-needle oil preparations were applied to the forearm of 46 subjects with healthy skin using standardised patches. The patches were removed after 48 hours and skin reactions were assessed immediately and after 24 and 48 hours. The major objective was the reaction of the patch test.


RESULTS
Neither preparation caused any positive skin reaction in any of the subjects.


CONCLUSIONS
Skin tolerability to the two eucalyptus oil and pine-needle oil preparations is very good with regard to their active ingredients and other excipients.
Willms
R U
RU
Praxis für Dermatologie und Venerologie, Magdeburg. heiro@gmx.de
Funk
P
P
Walther
C
C
D000287:Administration, Topical; D000328:Adult; D001991:Bronchitis / Q000188:drug therapy*; D003139:Common Cold / Q000188:drug therapy*; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D039821:Monoterpenes / Q000009:adverse effects; D009822:Oils, Volatile / Q000009:adverse effects*; D010328:Patch Tests; D008517:Phytotherapy / Q000009:adverse effects*; D028223:Pinus; D010938:Plant Oils / Q000627:therapeutic use*
D004338:Drug Combinations; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; C012384:ingalipt