From transcription to mRNA: PAF provides a new path.
Two new studies reveal a novel connection between transcription and pre-mRNA processing: the Paf1 elongation complex is involved in the 3' end formation of polyadenylated and nonpolyadenylated RNA polymerase II transcripts.
Rosonina
Emanuel
E
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Manley
James L
JL
D005786:Gene Expression Regulation; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D026721:RNA 3' End Processing / Q000502:physiology*; D012319:RNA Polymerase II / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors; D014158:Transcription, Genetic
D009687:Nuclear Proteins; C097698:PAF1 protein, S cerevisiae; C501972:PAF1 protein, human; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II