Nucleotide analogues to investigate RNA structure and function.
RNA plays an essential cellular role in nearly every aspect of the transmission and expression of genetic information, including regulatory roles that have significance for cellular development. Access to RNA bearing synthetic modifications has allowed biological chemists to probe deep into the inner workings of cellular processes. Here, we describe recent advances in harnessing the power of nucleotide analogues to obtain mechanistic and biological insights into RNA structure, function and dynamics.
Das
Subha R
SR
Howard Hughes Medical Institute, Department of Biochemistry & Molecular Biology, The University of Chicago, Chicago, Illinois 60637, USA.
Fong
Robert
R
Piccirilli
Joseph A
JA
D002384:Catalysis; D018360:Crystallography, X-Ray; D008670:Metals / Q000737:chemistry; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry* / Q000502:physiology*; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism
D008670:Metals; D009843:Oligoribonucleotides; D016337:RNA, Catalytic; D012313:RNA