Different gamma/delta T clones sustain GVM and GVH effects in multiple myeloma patients after non-myeloablative transplantation.
TCR gamma/delta profiles were analyzed in 13 multiple myeloma patients after allogeneic non-myeloablative transplantation. Results show that both aGVHD and minimal residual disease (MRD) eradication did significantly affect TCR gamma/delta profile. During follow-up, six patients developed an aGVHD episode; in five of them, this event fitted with a modification of the TCR profile. Eleven patients achieved PCR-negativity during follow-up. In the 90% of them, the appearance of a new predominant TCR peak was concomitant to the disappearance of the IgH clone. These results suggest that different T gamma/delta populations would sustain GVM and GVH effects after non-myeloablative allogeneic transplant.
Galimberti
Sara
S
Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, Ospedale S. Chiara, Via Roma, 56, 56100 PISA, Italy. s.galimberti@med.unipi.it
Benedetti
Edoardo
E
Morabito
Fortunato
F
Petrini
Iacopo
I
Battolla
Barbara
B
Papineschi
Federico
F
Fazzi
Rita
R
Ciabatti
Elena
E
Martino
Massimo
M
Cuzzola
Mariella
M
Console
Giuseppe
G
Iacopino
Pasquale
P
Petrini
Mario
M
D000328:Adult; D000368:Aged; D002999:Clone Cells; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D020350:Graft vs Tumor Effect / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D018365:Neoplasm, Residual / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis / Q000235:genetics*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D007143:Immunoglobulin Heavy Chains; D016692:Receptors, Antigen, T-Cell, gamma-delta