title: Severe hemolytic disease of the newborn due to anti-Cw.
abstract: BACKGROUND
  Pregnancies complicated by Rh isoimmunization have decreased significantly since the widespread use of Rh immune globulin. Uncommon red blood cell antigens have therefore become more clinically evident. We report a case of anti-Cw immunization that resulted in severe fetal anemia that required multiple transfusions.
  
  
  METHODS
  A 28-year-old multigravida presented to our service at 18 weeks of gestation with her fourth pregnancy. Her pregnancy was complicated by anti-Cw isoimmunization that resulted in severe fetal anemia requiring in utero fetal blood transfusions.
  
  
  CONCLUSIONS
  While previous reports recommend only postpartum surveillance when Cw isoimmunization is present, we report a case resulting in severe fetal anemia.
authors.affiliation: San Antonio Uniformed Services Health Education Consortium, Brooke Army Medical Center, San Antonio, Texas, USA. Benjamin.byers@sbcglobal.net
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Byers
authors.forename: Michael C
authors.initials: MC
authors.lastname: Gordon
authors.forename: Kenneth
authors.initials: K
authors.lastname: Higby
mesh_terms: D000328:Adult; D000751:Anemia, Neonatal / Q000209:etiology* / Q000628:therapy; D001787:Blood Group Incompatibility / Q000150:complications*; D001803:Blood Transfusion / Q000379:methods; D001805:Blood Transfusion, Intrauterine / Q000379:methods*; D004899:Erythroblastosis, Fetal / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D049590:Postpartum Period; D011247:Pregnancy; D011256:Pregnancy Outcome; D012203:Rh Isoimmunization / Q000150:complications
chemical_list: D007518:Isoantibodies; C051138:anti-c antibody