title: [A patient with coccidioidal meningoencephalitis].
abstract: A 37-year-old man presented with coccidioidal meningoencephalitis (CM) 1 month after a preceding case of pneumonia. Initially, he could not be definitely diagnosed with CM because of nonspecific features of the clinical, laboratory, and radiological findings. However, we began to suspect CM because the patient had lived in endemic area of coccidioidomycosis, and our subsequent analysis provided evidence of complement-fixing antibodies for Coccidioides immitis in serum and CSF, leading us to a final diagnosis. The CM was intractable, despite intensive administration of fluconazole and amphotericin B. Although the patient's CM gradually and mildly improved, he also suffered from bacterial meningoencephalitis and left putaminal hemorrhage with intraventricular hematoma, which caused persistent right hemiparesis and dementia. The incidence of coccidioidomycosis in Japan is rapidly increasing. The initial clinical manifestation of coccidioidomycosis is usually pneumonia, which in most cases heals spontaneously. Coccidioidomycosis rarely presents with meningoencephalitis, which is thought to be fatal. Immediate and adequate initiation of anti-fugal treatment is necessary to obtain a better prognosis for CM. Careful history-taking after a foreign trip is helpful when there is a suspicion of coccidioidomycosis.
authors.affiliation: Department of Neurology, Narita Red Cross Hospital.
authors.forename: Miho
authors.initials: M
authors.lastname: Nakata
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ito
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Kikkawa
authors.forename: Kaoru
authors.initials: K
authors.lastname: Katayama
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000908:Antibodies, Fungal / Q000032:analysis; D000935:Antifungal Agents / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging; D003045:Coccidioides / Q000276:immunology; D003047:Coccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy; D015725:Fluconazole / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008590:Meningoencephalitis / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000908:Antibodies, Fungal; D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole