The vitamin D epidemic and its health consequences.
Vitamin D deficiency is now recognized as an epidemic in the United States. The major source of vitamin D for both children and adults is from sensible sun exposure. In the absence of sun exposure 1000 IU of cholecalciferol is required daily for both children and adults. Vitamin D deficiency causes poor mineralization of the collagen matrix in young children's bones leading to growth retardation and bone deformities known as rickets. In adults, vitamin D deficiency induces secondary hyperparathyroidism, which causes a loss of matrix and minerals, thus increasing the risk of osteoporosis and fractures. In addition, the poor mineralization of newly laid down bone matrix in adult bone results in the painful bone disease of osteomalacia. Vitamin D deficiency causes muscle weakness, increasing the risk of falling and fractures. Vitamin D deficiency also has other serious consequences on overall health and well-being. There is mounting scientific evidence that implicates vitamin D deficiency with an increased risk of type I diabetes, multiple sclerosis, rheumatoid arthritis, hypertension, cardiovascular heart disease, and many common deadly cancers. Vigilance of one's vitamin D status by the yearly measurement of 25-hydroxyvitamin D should be part of an annual physical examination.
Holick
Michael F
MF
Boston University School of Medicine, Department of Medicine, Section of Endocrinology, Vitamin D Laboratory, Boston, MA 02118, USA. mfholick@bu.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000517:prevention & control; D001842:Bone and Bones / Q000502:physiology; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002762:Cholecalciferol / Q000096:biosynthesis; D004032:Diet; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D009369:Neoplasms / Q000517:prevention & control; D009751:Nutritional Requirements; D013472:Sunlight; D014807:Vitamin D / Q000008:administration & dosage / Q000096:biosynthesis / Q000502:physiology; D014808:Vitamin D Deficiency / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy
D014807:Vitamin D; D002762:Cholecalciferol