Oral squamous cell carcinoma. Cytometric parameters of prognostic interest.
OBJECTIVE
The present study was made in order to find possible prognostic factors in oral squamous cell carcinoma, given that it is a frequent disease (3-4% of all malignant tumors) and is the cause of a high morbidity and mortality which justifies any attempt to contribute something towards the understanding of this pathology.


METHODS
81 oral squamous cell carcinomas, treated with the same procedure, and retrieved from the archive of the Hospital Universitario Marqués de Valdecilla (Santander) were studied. Flow cytometry was carried out on 67 of the samples.


RESULTS
No statistically significant differences were found between the cellular proliferative index and the mitotic index, ploidy and the S-phase factor. Likewise, none of the cytometric variables studied presented any association with the appearance of local relapse, distant metastases or survival.


CONCLUSIONS
These variables cannot be used as a prognostic factors in squamous cell carcinomas of the oral cavity.
Saiz-Bustillo
Ramón
R
Servicio de Cirugía Oral y Maxilofacial, Hospital Universitario Marqués de Valdecilla, Santander. guacorch@yahoo.es
Corchero-Martín
Guadalupe
G
García-Montesinos-Perea
Belén
B
Gonzalez-Terán
Tomás
T
Sánchez-Santolino
Sergio
S
D000704:Analysis of Variance; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D049109:Cell Proliferation; D020732:Cytogenetic Analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D008940:Mitotic Index; D009062:Mouth Neoplasms / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D016196:S Phase; D016019:Survival Analysis
D004273:DNA, Neoplasm