title: Corticotropin-releasing factor binding protein--a ligand trap?
abstract: The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
authors.affiliation: Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Goettingen, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Jahn
authors.forename: Jelena
authors.initials: J
authors.lastname: Radulovic
authors.forename: Oliver
authors.initials: O
authors.lastname: Stiedl
authors.forename: Hossein
authors.initials: H
authors.lastname: Tezval
authors.forename: Klaus
authors.initials: K
authors.lastname: Eckart
authors.forename: Joachim
authors.initials: J
authors.lastname: Spiess
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D003072:Cognition Disorders / Q000188:drug therapy; D003346:Corticotropin-Releasing Hormone / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D018019:Receptors, Corticotropin-Releasing Hormone / Q000737:chemistry / Q000378:metabolism*; D054832:Urocortins
chemical_list: D002352:Carrier Proteins; D008024:Ligands; D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; C067133:corticotropin releasing factor-binding protein; D003346:Corticotropin-Releasing Hormone