Sublingual administration of Delta9-tetrahydrocannabinol/beta-cyclodextrin complex increases the bioavailability of Delta9-tetrahydrocannabinol in rabbits.
The bioavailability of Delta(9)-tetrahydrocannabinol (THC) was determined after its sublingual administration as solid THC/beta-cyclodextrin (THC/beta-CD) complex, and was compared to oral administration of ethanolic THC, in rabbits. The absolute bioavailability of THC after sublingual administration of solid THC/beta-CD complex powder (16.0 +/- 7.5%; mean +/- SD; n = 4) is higher than the bioavailability of THC after oral administration of ethanolic THC solution (1.3 +/- 1.4%; mean +/- SD; n = 4). The results suggest that sublingual administration of THC/beta-CD complex is a useful tool in improving absolute bioavailability of THC.
Mannila
Janne
J
Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland. janne.mannila@uku.fi
Järvinen
Tomi
T
Järvinen
Kristiina
K
Tervonen
Jussi
J
Jarho
Pekka
P
D000284:Administration, Oral; D000286:Administration, Sublingual; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D013759:Dronabinol / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D004333:Drug Administration Routes; D005079:Excipients / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
D005079:Excipients; D047392:beta-Cyclodextrins; D013759:Dronabinol