Magnetic resonance spectroscopy facilitates assessment of intramyocellular lipid changes: a preliminary short-term study following biliopancreatic diversion.
BACKGROUND
Intramyocellular content of lipid (IMCL) appears to be important in the pathogenesis of insulin resistance, and the improvement of insulin activity observed following biliopancreatic diversion (BPD) for obesity has to be related to reduction of IMCL. This study evaluates the possibility of detecting changes after BPD in IMCL by means of H1 magnetic resonance spectroscopy.


METHODS
The investigation was carried out in obese patients undergoing BPD prior to and at 1 month following the operation. Insulin sensitivity was assessed according to the homeostatic model of assessment (HOMA), and IMCL was determined by the spectroscopy of the tibialis anterior muscle.


RESULTS
At 1 month following BPD, an improvement in insulin action was observed in all subjects, and in nearly all cases the IMCL signal decreased.


CONCLUSIONS
The data from this study indicate that magnetic resonance spectroscopy can detect IMCL changes following BPD and is fully suitable for longitudinal studies on muscle metabolic status.
Adami
Gian Franco
GF
Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy. adami@unige.it
Parodi
Roberto Carlo
RC
Papadia
Francesco
F
Marinari
Giuseppe
G
Camerini
Giovanni
G
Corvisieri
Roberta
R
Scopinaro
Nicola
N
D000328:Adult; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000737:chemistry*; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery*
D001786:Blood Glucose; D008055:Lipids