title: [Methodological studies on selectively removing toxins in Aristolochiae manshuriensis by chinese processing techniques].
abstract: OBJECTIVE
  To investigate the possibility of selectively detoxifying aristolochic acids in Aristolochiae manshuriensis (Guanmutong) by the chemical properties of aristolochic acids and traditional Chinese processing experience.
  
  
  METHODS
  The technical parameters in processing technique of A. manshuriensis were optimized by orthogonal designed methods with aristolochic acid A.
  
  
  RESULTS
  The processing technique was soaked in 0.1 mol x L(-1) baking soda for several times and then processing with vinegar. Temperature was important factor to detoxify aristolochic acids. aristolochic acid A were removed over 90% from A. manshuriensis in laboratory and over 80% in medium-scale production by 10 batches from two origins of botanical drugs with different contents, and decreased to 0.35-0.60 mg x g(-1) in processed products. aristolochic acid A existed mostly salt-forms in the botanical drug.
  
  
  CONCLUSIONS
  Most toxic components in Guanmutong could be removed by the new processing method.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. zhmw123@263.net
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Li-shuang
authors.initials: LS
authors.lastname: You
authors.forename: Xu
authors.initials: X
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Wei-hao
authors.initials: WH
authors.lastname: Wang
authors.forename: Guan
authors.initials: G
authors.lastname: Wang
mesh_terms: D019342:Acetic Acid; D030022:Aristolochia / Q000737:chemistry*; D034341:Aristolochic Acids / Q000032:analysis*; D006358:Hot Temperature; D019999:Pharmaceutical Solutions / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D017693:Sodium Bicarbonate; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
chemical_list: D034341:Aristolochic Acids; D019999:Pharmaceutical Solutions; D017693:Sodium Bicarbonate; C000228:aristolochic acid I; D019342:Acetic Acid