Ring-closing metathesis reactions in nucleic acid chemistry-cyclic dinucleotides for targeting secondary nucleic acid structures.
Cyclic dinucleotides are synthesized using a ring-closing metathesis protocol and incorporated into oligonucleotides. A stabilization of a three-way junction is observed by an oligodeoxynucleotide containing a central 2'-C to 3'-phosphate connection.
Nielsen
Poul
P
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Børsting
Philip
P
D015226:Dinucleoside Phosphates / Q000737:chemistry; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D009841:Oligonucleotides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
D015226:Dinucleoside Phosphates; D009711:Nucleotides; D009841:Oligonucleotides; D010710:Phosphates