Pathophysiological significance of T-type Ca2+ channels: transcriptional regulation of T-type Ca2+ channel--regulation of CACNA1H by neuron-restrictive silencer factor.
Expression of T-type Ca(2+) current in the ventricle varies during development and in cardiac diseases. The alteration in quantity of two isoforms of T-type Ca(2+) channel genes in the heart, CACNA1G and CACNA1H, contributes to the changes of T-type Ca(2+) channel activity. However, the precise mechanisms governing the transcription of T-type Ca(2+) channel genes remain largely unknown. In this review, we briefly describe our recent finding that a transcriptional repressor named neuron-restrictive silencer factor is a potent regulator of T-type Ca(2+) channel gene expression.
Kuwahara
Koichiro
K
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan. koichiro.kuwahara@UTSouthwestern.edu
Takano
Makoto
M
Nakao
Kazuwa
K
D000818:Animals; D020747:Calcium Channels, T-Type / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic; D000099229:RE1-Silencing Transcription Factor
D020747:Calcium Channels, T-Type; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor; C479952:CACNA1H protein, human