Dexamethasone suppresses human interleukin-5 gene promoter.
Synthetic glucocorticoid dexamethasone suppressed interleukin-5 gene expression in PER-117 human T cells at the level of transcription. The conserved lymphokine element 0 in the interleukin-5 gene promoter context served as a target for dexamethasone.
Mordvinov
V A
VA
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. mordvin@bionet.nsc.ru
Kok
C C
CC
Arthaningtyas
E
E
Schwenger
G T F
GT
Cristow
A
A
Sanderson
C J
CJ
D002478:Cells, Cultured; D017931:DNA Primers; D003907:Dexamethasone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D015848:Interleukin-5 / Q000235:genetics* / Q000378:metabolism; D008156:Luciferases; D009841:Oligonucleotides / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000187:drug effects* / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism*; D014162:Transfection
D017931:DNA Primers; D015848:Interleukin-5; D009841:Oligonucleotides; D003907:Dexamethasone; D008156:Luciferases