title: Demonstration of reversed flow in segmental branches of the portal vein with hand-held color Doppler ultrasonography after hematopoietic stem cell transplantation.
abstract: Hepatic veno-occlusive disease (VOD) is a severe complication of hematopoietic stem cell transplantation (SCT). When monitored with hand-held color Doppler ultrasonography during day -7 to +35 around SCT, reversed blood flow in the segmental branches of the portal vein was detected in nine of 56 patients who had undergone SCT. Three of nine patients had clinical evidence of VOD, but six patients did not fulfill the criteria for diagnosis of VOD initially. Two patients progressed to clinical VOD at a later date and the reversed portal flow disappeared with or without treatment for VOD in the other four patients. Monitoring for reversed portal flow with color Doppler ultrasonography may be a useful tool for the early diagnosis of VOD, and may improve prognosis by allowing early initiation of treatment.
authors.affiliation: Second Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hashiguchi
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: R
authors.initials: R
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Yakushiji
authors.forename: H
authors.initials: H
authors.lastname: Ogata
authors.forename: R
authors.initials: R
authors.lastname: Seki
authors.forename: K
authors.initials: K
authors.lastname: Otsubo
authors.forename: E
authors.initials: E
authors.lastname: Oku
authors.forename: M
authors.initials: M
authors.lastname: Kuroiwa
authors.forename: M
authors.initials: M
authors.lastname: Higuchi
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Gondo
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
authors.forename: K
authors.initials: K
authors.lastname: Nagafuji
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Sata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D018450:Disease Progression; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods*; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography / Q000379:methods; D018608:Ultrasonography, Doppler / Q000379:methods*; D014580:Ursodeoxycholic Acid / Q000494:pharmacology
chemical_list: D014580:Ursodeoxycholic Acid