The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.
Banerji
Biswadip
B
Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UKOX1 3TA.
Conejo-Garcia
Ana
A
McNeill
Luke A
LA
McDonough
Michael A
MA
Buck
Matthew R G
MR
Hewitson
Kirsty S
KS
Oldham
Neil J
NJ
Schofield
Christopher J
CJ
D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D010105:Oxygenases / Q000378:metabolism; D014176:Protein Biosynthesis; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
D002264:Carboxylic Acids; D012097:Repressor Proteins; D014157:Transcription Factors; D010105:Oxygenases