Pea3 expression is regulated by FGF signaling in developing retina.
FGF signaling has been implicated as an important regulator of retinal development. As a first step in characterizing potential downstream targets of FGF signaling in the retina, we have analyzed expression of Pea3, a member of the Pea3 class of Ets-domain transcription factors, in the developing eye. We find that Pea3 is expressed in the developing retina, and its transcription is regulated by FGF receptor activation. In addition, FGF signaling activates Cath5, a gene necessary for retinal ganglion cell differentiation. These results suggest that FGF signaling via MAPK up-regulates transcription factors that in turn control retinal ganglion cell differentiation.
McCabe
Kathryn Leigh
KL
Department of Biology, California Institute of Technology, Pasadena, California 91125, USA. klm@caltech.edu
McGuire
Chris
C
Reh
Thomas A
TA
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D002454:Cell Differentiation; D002642:Chick Embryo; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005419:Flavonoids / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000235:genetics*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics
D051792:Basic Helix-Loop-Helix Proteins; D005346:Fibroblast Growth Factors; D005419:Flavonoids; D047428:Protein Kinase Inhibitors; D012333:RNA, Messenger; D014157:Transcription Factors; C065788:transcription factor PEA3; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one