Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein.
Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.
Kim
Hye-Young
HY
Department of Chemistry and Center for Molecular Toxicology, Vanderbilt University, Nashville, TN 37235, USA.
Pratt
Derek A
DA
Seal
Jennifer R
JR
Wijtmans
Maikel
M
Porter
Ned A
NA
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014364:Tryptophan / Q000737:chemistry; D024502:alpha-Tocopherol / Q000097:blood / Q000737:chemistry*
D000975:Antioxidants; D008077:Lipoproteins, LDL; D011725:Pyridines; C023500:3-hydroxypyridine; D014364:Tryptophan; D024502:alpha-Tocopherol