Lack of association of SDF-1 3'A variant allele with long-term nonprogressive HIV-1 infection is extended beyond 16 years.
We studied the frequency of the SDF-1 3'A allelic variant (801G-->A) in a cohort of white Spaniards made up of (1) HIV-1-infected long-term nonprogressors (LTNPs) older than 16 years of age (n = 57), (2) HIV-1-infected usual progressors (UPs; n = 107), and (3) a group of healthy controls (n = 100). The mutant SDF-1 3'A allele was observed in 28% of LTNPs, 19% of UPs, and 26% of healthy controls (P = not significant). Homozygosity for the 3'A mutation was detected in 7%, 4%, and 3% of LTNPs, UPs, and healthy controls, respectively (P = not significant). Polymorphism at the SDF-1 locus is not associated with LTNP disease of longer than 16 years in Spanish HIV-1-infected patients. This effect is independent of the CCR5Delta32 allele.
Vidal
Francesc
F
Hospital Universitari de Tarragona Joan XXIII and Universitat Rovira i Virgili, Tarragona, Catalonia, Spain. fvidal@comt.es
Peraire
Joaquim
J
Domingo
Pere
P
Broch
Montserrat
M
Knobel
Hernando
H
Pedrol
Enric
E
Dalmau
David
D
Viladés
Consuelo
C
Sambeat
Ma Antònia
MA
Gutiérrez
Cristina
C
Richart
Cristóbal
C
D000328:Adult; D000483:Alleles; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology; D020276:HIV Long-Term Survivors; D015497:HIV-1; D006720:Homozygote; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D013030:Spain
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC