title: Embryo culture does not affect the longevity of offspring in mice.
abstract: The oldest assisted reproductive technologies (ART)-conceived child is only 27 years old. Thus, the effects of ART on longevity are unknown, and it will be many years before this can be assessed in humans. We recently reported that culturing preimplantation mouse embryos under suboptimal conditions results in differences in how the offspring perform in behavioral assays that reflect anxiety (elevated zero maze) and spatial memory (Morris hidden water maze; Ecker et al. 2004). Here we monitored the mice generated in our previous study and found no difference in their longevity.
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Joshua
authors.initials: J
authors.lastname: Sommovilla
authors.forename: Warren B
authors.initials: WB
authors.lastname: Bilker
authors.forename: Ted
authors.initials: T
authors.lastname: Abel
authors.forename: Richard M
authors.initials: RM
authors.lastname: Schultz
mesh_terms: D000375:Aging; D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D046149:Embryo Culture Techniques; D005260:Female; D005838:Genotype; D008136:Longevity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D012044:Regression Analysis; D027724:Reproductive Techniques, Assisted; D012737:Sex Factors