A genotype probability index for multiple alleles and haplotypes.
We use linear algebra to calculate an index of information content in genotype probabilities which has previously been calculated using trigonometry. The new method can be generalized allowing the index to be calculated for loci with more than two alleles. Applications of this index include its use in genotyping strategies, strategies to manage genetic disorders and in estimation of genotype effects.
Percy
A
A
School of Applied Science and Engineering, Monash University, Gippsland, Australia. andrew.percy@sci.monash.edu.au
Kinghorn
B P
BP
D000483:Alleles; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D008957:Models, Genetic; D011336:Probability