Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages.
An in-depth study into the incorporation of multiple 3-S-phosphorothiolate modifications into oligodeoxynucleotides (ODNs) and their subsequent effect on ODN/DNA and ODN/RNA duplex stability. 3-S-Phosphorothiolate linkages increase the stability of ODN/RNA duplexes and decrease the stability of ODN/DNA duplexes.
Buckingham
Joanne
J
Department of Chemistry, University of Liverpool, Crown St, Liverpool L69 7ZD, UK. joannebuckingham@yahoo.co.uk
Sabbagh
Ghalia
G
Brazier
John
J
Fisher
Julie
J
Cosstick
Rick
R
D004247:DNA / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics; D013873:Thionucleotides / Q000737:chemistry*
D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D013873:Thionucleotides; D010758:Phosphorus; D012313:RNA; D004247:DNA