title: Pathophysiological significance of T-type Ca2+ channels: transcriptional regulation of T-type Ca2+ channel--regulation of CACNA1H by neuron-restrictive silencer factor.
abstract: Expression of T-type Ca(2+) current in the ventricle varies during development and in cardiac diseases. The alteration in quantity of two isoforms of T-type Ca(2+) channel genes in the heart, CACNA1G and CACNA1H, contributes to the changes of T-type Ca(2+) channel activity. However, the precise mechanisms governing the transcription of T-type Ca(2+) channel genes remain largely unknown. In this review, we briefly describe our recent finding that a transcriptional repressor named neuron-restrictive silencer factor is a potent regulator of T-type Ca(2+) channel gene expression.
authors.affiliation: Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan. koichiro.kuwahara@UTSouthwestern.edu
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kuwahara
authors.forename: Makoto
authors.initials: M
authors.lastname: Takano
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000818:Animals; D020747:Calcium Channels, T-Type / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D012097:Repressor Proteins / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic; D000099229:RE1-Silencing Transcription Factor
chemical_list: D020747:Calcium Channels, T-Type; D012097:Repressor Proteins; D014157:Transcription Factors; D000099229:RE1-Silencing Transcription Factor; C479952:CACNA1H protein, human