[The rimantadine sensitivity spectrum in influenza A viruses circulating in the 2002-2004 epidemic seasons].
A total of 200 influenza A virus strains were studied. Among them there 32 strains of A(H1N1) and 84 strains of A(H3N2) from the 2002-2003 epidemic season and 84 strains of A(H3N2) from the 2003-2004 epidemic season. Most rimantadine-sensitive strains whose infectivity and hemagglutinating activity were found to decrease by the drug given at a concentration of 0.5 microg/ml. In terms of infectivity and hemagglutinating activity, the number of rimantadine-resistant strains of A (H1N1) was equal to 9.0% for A(H1N1) influenza viruses and to 10.0 and 14.0% for A (H3N2) influenza viruses in different seasons, respectively.
Shevchenko
E S
ES
Burtseva
E I
EI
Slepushkin
A N
AN
Merkulova
L N
LN
Gatich
R Z
RZ
Ivanova
V T
VT
Oskerko
T A
TA
D000998:Antiviral Agents / Q000494:pharmacology*; D004196:Disease Outbreaks; D024882:Drug Resistance, Viral; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000821:virology*; D008826:Microbial Sensitivity Tests; D012299:Rimantadine / Q000494:pharmacology*; D012426:Russia / Q000453:epidemiology; D013045:Species Specificity
D000998:Antiviral Agents; D012299:Rimantadine