title: Intraoral delivery of antimicrobials.
abstract: Antimicrobial therapies for oral diseases have been in use for centuries, but have undergone rapid changes in the last decade. In the coming years, antimicrobial strategies will become more sophisticated and efficacy will be greatly improved as new therapeutic technologies emerge. New delivery systems for common antimicrobials and novel agents to modulate the immune system, as well as biofilm formation and maturation, may be on the horizon. This review describes the development and the application of intraoral antimicrobial drug delivery in the oral environment. Current clinical uses of antimicrobials as well as future approaches to the treatment and prevention of oral infectious diseases are discussed.
authors.affiliation: Division of Periodontics and Department of Surgical Sciences, School of Dentistry, Marquette University, Milwaukee, Wisconsin 53201, USA.
authors.forename: Periathamby Antony
authors.initials: PA
authors.lastname: Raj
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Dentino
mesh_terms: D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D018441:Biofilms / Q000187:drug effects; D002986:Clinical Trials as Topic; D023082:Defensins / Q000008:administration & dosage / Q000627:therapeutic use; D003773:Dental Plaque / Q000188:drug therapy* / Q000382:microbiology; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D005891:Gingivitis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D010456:Peptides, Cyclic / Q000008:administration & dosage / Q000627:therapeutic use; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D011506:Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D013282:Stomatitis, Denture / Q000188:drug therapy* / Q000382:microbiology; D000099053:Histidine-Rich Glycoprotein
chemical_list: D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D023082:Defensins; D004337:Drug Carriers; D010456:Peptides, Cyclic; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein; C056454:bactenecin