Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques.
Peptide YY(3-36) [PYY(3-36)] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however, there are conflicting reports of the effects of PYY(3-36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY(3-36) on food intake and body weight in a nonhuman primate. Intravenous PYY(3-36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h intake. Twice-daily or continuous intravenous PYY(3-36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding for the morning but not the evening meal. Twice-daily intravenous PYY(3-36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing insulin response to glucose infusion. These results show that endogenous PYY(3-36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food intake.
Koegler
Frank H
FH
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
Enriori
Pablo J
PJ
Billes
Sonja K
SK
Takahashi
Diana L
DL
Martin
Meghan S
MS
Clark
Randall L
RL
Evans
Anne E
AE
Grove
Kevin L
KL
Cameron
Judy L
JL
Cowley
Michael A
MA
D000818:Animals; D004334:Drug Administration Schedule; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005951:Glucose Tolerance Test; D008253:Macaca mulatta / Q000378:metabolism*; D008297:Male; D010446:Peptide Fragments; D019894:Peptide YY / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D015431:Weight Loss / Q000187:drug effects*
D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)