title: Neurotrophic factor expression in three infants with Ondine's curse.
abstract: This study investigates the expression of some neurotrophic factors (brain-derived neurotrophic factor, glial-derived neurotrophic factor, and nerve growth factor) in the cerebrospinal fluid of infants suffering from idiopathic congenital central hypoventilation syndrome and determines their correlations with this syndrome. Cerebrospinal fluid samples were collected from three infants suffering from idiopathic congenital central hypoventilation syndrome and 15 control subjects with obstructive hydrocephalus to measure the expression of brain-derived neurotrophic factor, glial-derived neurotrophic factor, and nerve growth factor using an immunoenzymatic assay. In the cerebrospinal fluid of patients, analysis of neurotrophic factors expression indicated a reduction, not statistically significant, of brain-derived neurotrophic factor compared with the mean level of the control group (1554 pg/mL, 1509 pg/mL, and 1582 pg/mL respectively, in comparison to 1954 +/- 103 pg/mL), whereas nerve growth factor and glial-derived neurotrophic factor did not undergo significant variations in either group. Neurotrophic factors, namely brain-derived neurotrophic factor, regulate the maturation and differentiation of respiratory neurons. The reduced expression of brain-derived neurotrophic factor in the cerebrospinal fluid samples of infants with Ondine's curse, although not statistically significant, is suggestive of a dysregulation in the brain-derived neurotrophic factor synthesis that could play an important role in the breathing disorders observed in patients with idiopathic congenital central hypoventilation syndrome.
authors.affiliation: Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Chiaretti
authors.forename: Giulia
authors.initials: G
authors.lastname: Zorzi
authors.forename: Concezio
authors.initials: C
authors.lastname: Di Rocco
authors.forename: Orazio
authors.initials: O
authors.lastname: Genovese
authors.forename: Alessia
authors.initials: A
authors.lastname: Antonelli
authors.forename: Marco
authors.initials: M
authors.lastname: Piastra
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Polidori
authors.forename: Luigi
authors.initials: L
authors.lastname: Aloe
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020932:Nerve Growth Factor / Q000134:cerebrospinal fluid; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D020182:Sleep Apnea, Central / Q000134:cerebrospinal fluid* / Q000151:congenital / Q000503:physiopathology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020932:Nerve Growth Factor