title: Bystin in perineural invasion of prostate cancer.
abstract: BACKGROUND
  Bystin, Trophinin, and Tastin are component proteins of an adhesion molecule complex that plays a crucial role in the initial attachment of the embryo to the uterus.
  
  
  METHODS
  Profiling of genes differentially expressed in the perineural invasion (PNI) in vitro model by gene microarray analysis showed overexpression of bystin in prostate cancer cells co-cultured with nerves. Validation was performed at the RNA levels using quantitative PCR.
  
  
  RESULTS
  Bystin is overexpressed in cells co-cultured with nerves. Bystin is also present in human prostatic carcinoma (PCa) cells in PNI location in increasing gradient. Bystin is present in the supernatant of the PNI co-culture.
  
  
  CONCLUSIONS
  Their adhesive and invasive functions in the trophoblast suggest that they might also play a role in perineural adhesion. Bystin is, therefore, an important therapeutic target for neurotropic cancers.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA. gayala@bcm.tmc.edu
authors.forename: Gustavo E
authors.initials: GE
authors.lastname: Ayala
authors.forename: Hong
authors.initials: H
authors.lastname: Dai
authors.forename: Rile
authors.initials: R
authors.lastname: Li
authors.forename: Michael
authors.initials: M
authors.lastname: Ittmann
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Thompson
authors.forename: David
authors.initials: D
authors.lastname: Rowley
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Wheeler
mesh_terms: D000818:Animals; D015153:Blotting, Western; D015815:Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D005727:Ganglia, Spinal; D006801:Humans; D008297:Male; D051379:Mice; D009361:Neoplasm Invasiveness; D020411:Oligonucleotide Array Sequence Analysis; D010525:Peripheral Nerves / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D012334:RNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C112245:BYSL protein, human; D015815:Cell Adhesion Molecules; D012334:RNA, Neoplasm