title: The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
abstract: A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.
authors.affiliation: Department of Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Andy.K.Takle@gsk.com
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Takle
authors.forename: Murray J B
authors.initials: MJ
authors.lastname: Brown
authors.forename: Susannah
authors.initials: S
authors.lastname: Davies
authors.forename: David K
authors.initials: DK
authors.lastname: Dean
authors.forename: Gerraint
authors.initials: G
authors.lastname: Francis
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gaiba
authors.forename: Alex W
authors.initials: AW
authors.lastname: Hird
authors.forename: Frank D
authors.initials: FD
authors.lastname: King
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Lovell
authors.forename: Antoinette
authors.initials: A
authors.lastname: Naylor
authors.forename: Alastair D
authors.initials: AD
authors.lastname: Reith
authors.forename: Jon G
authors.initials: JG
authors.lastname: Steadman
authors.forename: David M
authors.initials: DM
authors.lastname: Wilson
mesh_terms: D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; C508204:SB-590885; D048493:Proto-Oncogene Proteins B-raf