Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.
Phosphoglucomutase catalyses the reversible conversion of glucose-6-P and glucose-1-P. Lithium is a potent inhibitor of phosphoglucomutase in vitro, however, it is not known if phosphoglucomutase was significantly inhibited by Li+ in Li+-treated bipolar patients. Here, we demonstrate that phosphoglucomutase inhibition by chronic Li+ treatment causes alterations of glucose-phosphate levels in various tissues of rats. Also, phosphoglucomutase inhibition results in compensatory elevation of phosphoglucomutase activity in rat tissues and in leukocytes isolated from Li+-treated bipolar patients. The increase of uninhibited phosphoglucomutase activity in leukocytes of Li+-treated bipolar patients is due to the increased expression of the PGM1 gene.
Csutora
Péter
P
Department of Laboratory Medicine, Pécs University, Pécs, Hungary.
Karsai
Arpád
A
Nagy
Tamás
T
Vas
Bálint
B
L Kovács
Gábor
G
Rideg
Orsolya
O
Bogner
Péter
P
Miseta
Attila
A
D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002118:Calcium / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D018021:Lithium Chloride / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010733:Phosphoglucomutase / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D018692:Antimanic Agents; D005958:Glucosephosphates; D012333:RNA, Messenger; D019298:Glucose-6-Phosphate; C031590:glucose-1-phosphate; D010733:Phosphoglucomutase; D018021:Lithium Chloride; D008274:Magnesium; D002118:Calcium