title: Neoadjuvant chemotherapy in vulvar cancer: avoiding primary exenteration.
abstract: OBJECTIVE
  To determine whether neoadjuvant cisplatin and 5-fluorouracil chemotherapy can be used to preserve the anal sphincter and/or urethra in patients with advanced vulvar cancer involving these sites.
  
  
  METHODS
  Fourteen patients with advanced vulvar cancer (1997-2003) involving the anal sphincter and/or urethra were given 3-4 cycles of neoadjuvant chemotherapy to attempt preservation of these pelvic structures rather than undergoing a primary pelvic exenteration. Following 3 cycles, a radical vulvectomy and groin lymph node dissection were planned. All patients had lesion size documented by measurement and photograph prior to and following chemotherapy.
  
  
  RESULTS
  The median age was 63 years (range 39-88). Thirteen patients received a median of 3 cycles (range 2-4) of neoadjuvant chemotherapy. Ten patients received cisplatin and 5-fluorouracil, while three received cisplatin alone. The median time from diagnosis to surgery was 77 days (range 54-143). All patients with cisplatin and 5-fluorouracil chemotherapy underwent surgery except one patient who had a synchronous renal cell carcinoma and died prior to surgery. Patients receiving cisplatin alone showed no measurable response, while all patients receiving cisplatin and 5-fluorouracil demonstrated at least a partial response. Two patients had no residual invasive carcinoma on final pathology. All patients receiving cisplatin and 5-fluorouracil followed by surgery are disease-free, while two of three receiving cisplatin have progressive disease. The anal sphincter and urethra were conserved in all patients receiving cisplatin and 5-fluorouracil.
  
  
  CONCLUSIONS
  Neoadjuvant cisplatin and 5-fluorouracil in advanced vulvar cancer demonstrated a response rate of 100%. The anal sphincter and urethra were conserved in all patients receiving cisplatin and 5-fluorouracil. Responders are disease-free at this time. This response rate demonstrates superior activity of 5-fluorouracil in vulvar cancer and spares these patients the morbidity of exenteration or radiation.
authors.affiliation: Indiana Women's Oncology, University of Iowa-Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, St. Vincent Hospitals, 8301 Harcourt Road, Suite 201, Indianapolis, IN 46260, USA. jgeisler@indianawomensoncology.com
authors.forename: John P
authors.initials: JP
authors.lastname: Geisler
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Manahan
authors.forename: Richard E
authors.initials: RE
authors.lastname: Buller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010385:Pelvic Exenteration; D014846:Vulvar Neoplasms / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil