title: Looking glass inhibitors: efficient synthesis and biological evaluation of D-deoxyfuconojirimycin.
abstract: 1,6-Dideoxygalactostatin, the mirror image of 1-deoxy-L-fuconojirimycin, was efficiently prepared from 2,3-O-isopropylidene-L-lyxonolactone in four steps and evaluated as a glycosidase inhibitor.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. yves.bleriot@chimie.ens.fr
authors.forename: Yves
authors.initials: Y
authors.lastname: Blériot
authors.forename: Dirk
authors.initials: D
authors.lastname: Gretzke
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Krülle
authors.forename: Terry D
authors.initials: TD
authors.lastname: Butters
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Dwek
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Nash
authors.forename: Naoki
authors.initials: N
authors.lastname: Asano
authors.forename: George W J
authors.initials: GW
authors.lastname: Fleet
mesh_terms: D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D006801:Humans; D050112:Imino Pyranoses / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D050112:Imino Pyranoses; D013402:Sugar Alcohols; D017485:1-Deoxynojirimycin; C062662:deoxyfuconojirimycin; D006026:Glycoside Hydrolases