Blood coagulation initiates respiratory burst in neutrophils.
Using the in vitro reaction of nitroblue tetrazolium reduction we showed that blood coagulation stimulates production of reactive oxygen species by human neutrophils. Heparin and chondroitin sulfate produced by thrombin-activated basophils are good candidates for inductors of these processes. Similar activation probably occurs in vivo under the influence of inductors secreted by mast cells.
Gerasimov
I G
IG
Institute for Medical Problems of Family, M. Gorky Donetsk State Medical University.
Ignatov
D Yu
DY
D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D002809:Chondroitin Sulfates; D005260:Female; D006493:Heparin / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D009580:Nitroblue Tetrazolium; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016897:Respiratory Burst / Q000502:physiology*
D017382:Reactive Oxygen Species; D009580:Nitroblue Tetrazolium; D006493:Heparin; D002809:Chondroitin Sulfates