Hypercoagulability markers in young asymptomatic heterozygous carriers of factor V Leiden (G1691A) or prothrombin (G20210A) variant.
BACKGROUND
Mutations in factor V (factor V Leiden-G1691A) and prothrombin (G20210A) genes are important risk factors for thrombophilia due to their high incidence in patients with thromboembolic events, especially among the young. However, it is not clear if levels of hypercoagulability markers are significantly altered in asymptomatic young carriers of factor V Leiden or prothrombin G20210A.


METHODS
Hemostatic status of 32 asymptomatic young individuals carrying these mutations and of 18 normal control individuals was investigated through the determination of plasma thrombomodulin (TM), prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT) and D-dimer.


RESULTS
No significant differences were observed in these hemostatic markers when comparing groups of individuals carrying mutations and the control group.


CONCLUSIONS
Analysis of these results leads to the conclusion that the presence of these mutations, in the absence of acquired risk factors, does not constantly predispose these young carriers to a state of hypercoagulability.
Godoi
Lara Carvalho
LC
Faculty of Pharmacy, Federal University of Minas Gerais-Belo Horizonte/Minas Gerais, Brazil.
Fernandes
Ana Paula
AP
Vieira
Lauro Mello
LM
Melgaço
Daniela Amorim
DA
de Bastos
Marcos
M
Ribeiro
Monica de F
Mde F
Carvalho
Maria das Graças
Md
Dusse
Luci Maria Sant Ana
LM
D000328:Adult; D001778:Blood Coagulation Disorders / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011516:Prothrombin / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin