[Evaluation of repellent and anti-feeding effect of garlic oil (Allium sativum) against the bite of phlebotomine sandflies Diptera: Psychodidae].
The repellent and anti-feeding effect of garlic oil was evaluated in laboratory conditions against the bite of Phlebotomus papatasi females. The effectiveness was evaluated by two different laboratory procedures: (i) topical application of garlic oil on five human volunteers, using the "standard cage test", and (ii) feeding sandflies on artificial membranes treated with the compound. Garlic oil showed a significant protection by topical application on the skin of volunteers, being the protection 97% and 40%, respectively at 1% and 0.005% dilution. Garlic oil showed also an anti-feeding effect when tested on the artificial membrane feeding apparatus; the anti-feeding effect was dose dependent, being 100% at 1%. The results of the present study confirm previous observations on the repellent effect of garlic oil against haematophagous arthropods.
Valerio
Laura
L
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Roma.
Maroli
Michele
M
D000279:Administration, Cutaneous; D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005737:Garlic / Q000737:chemistry*; D006225:Hand; D006801:Humans; D007299:Insect Bites and Stings / Q000517:prevention & control*; D007302:Insect Repellents / Q000008:administration & dosage / Q000494:pharmacology*; D007303:Insect Vectors / Q000187:drug effects*; D007896:Leishmaniasis / Q000517:prevention & control / Q000635:transmission; D010691:Phlebotomus / Q000187:drug effects*; D011817:Rabbits; D013440:Sulfides / Q000494:pharmacology*
D000498:Allyl Compounds; D007302:Insect Repellents; D013440:Sulfides; C038491:allyl sulfide