title: N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus.
abstract: Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.
authors.affiliation: Pharmasset, Inc., 1860 Montreal Road, Tucker, GA 30084, USA. jdu@pharmasset.com
authors.forename: Jinfa
authors.initials: J
authors.lastname: Du
authors.forename: Laurent
authors.initials: L
authors.lastname: Hollecker
authors.forename: Junxing
authors.initials: J
authors.lastname: Shi
authors.forename: Byoung-Kwon
authors.initials: BK
authors.lastname: Chun
authors.forename: Kyoichi A
authors.initials: KA
authors.lastname: Watanabe
authors.forename: F Schinazi
authors.initials: FS
authors.lastname: Raymond
authors.forename: Tammy Y
authors.initials: TY
authors.lastname: Nachman
authors.forename: Stefania
authors.initials: S
authors.lastname: Lostia
authors.forename: Lieven J
authors.initials: LJ
authors.lastname: Stuyver
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003596:Cytosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D004148:Dioxolanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006515:Hepatitis B virus; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004148:Dioxolanes; D009705:Nucleosides; D003596:Cytosine; C010962:formal glycol