Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia.
A serotonin transporter gene linked polymorphic region (5-HTTLPR) has been investigated in several genetic association studies, including studies of schizophrenia and suicidality. The current study was designed to examine whether the new long (A/G) variant polymorphism of the 5-HTT gene may be associated with suicide attempts of 290 Caucasian schizophrenic patients. Among these patients, 92 had a history of suicide attempt. No association with history of suicide attempt was found in the multiallelic 5-HTTLPR (p = 0.305), however we found significant association with the intron 2 VNTR polymorphism (p = 0.018). When we performed a haplotype analysis, we found association between suicide attempt and haplotype distribution (p = 0.031). These findings suggest that the intron 2 VNTR polymorphism in serotonin transporter gene may influence suicidal behaviour in schizophrenia.
De Luca
Vincenzo
V
Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street R-30, Toronto, Ontario, Canada M5T 1R8. Vincenzo_Deluca@camh.net
Zai
Gwyneth
G
Tharmalingam
Subi
S
de Bartolomeis
Andrea
A
Wong
Greg
G
Kennedy
James L
JL
D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007438:Introns; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012044:Regression Analysis; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013406:Suicide, Attempted
D050486:Serotonin Plasma Membrane Transport Proteins