title: t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma.
abstract: Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.
authors.affiliation: Department of Haematological Oncology, University of Leeds, United Kingdom. j.a.l.fenton@leeds.ac.uk
authors.forename: James A L
authors.initials: JA
authors.lastname: Fenton
authors.forename: Ed
authors.initials: E
authors.lastname: Schuuring
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Barrans
authors.forename: Alison H
authors.initials: AH
authors.lastname: Banham
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Rollinson
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Morgan
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Jack
authors.forename: J Han J M
authors.initials: JH
authors.lastname: van Krieken
authors.forename: Philip M
authors.initials: PM
authors.lastname: Kluin
mesh_terms: D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14; D002893:Chromosomes, Human, Pair 3; D017931:DNA Primers; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D016393:Lymphoma, B-Cell / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D017931:DNA Primers; C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins