Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant DeltaV2 Env.
The promising results obtained with the HIV-1 Tat-based vaccines in mice, monkeys and humans, a better understanding of Tat immunomodulatory functions, as well as evidence that vaccination with trimeric V2 loop-deleted HIV-1 Env induces cross-clade neutralizing antibodies led to the rational design of a novel vaccine based on the combination of Tat and V2-deleted Env.
Ensoli
Barbara
B
AIDS National Center, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy. ensoli@iss.it
Cafaro
Aurelio
A
Caputo
Antonella
A
Fiorelli
Valeria
V
Ensoli
Fabrizio
F
Gavioli
Riccardo
R
Ferrantelli
Flavia
F
Cara
Andrea
A
Titti
Fausto
F
Magnani
Mauro
M
D016915:AIDS Vaccines / Q000009:adverse effects / Q000235:genetics / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology*; D015696:Gene Products, tat / Q000235:genetics / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D023421:Models, Animal; D009500:Neutralization Tests; D017778:Vaccines, Combined / Q000009:adverse effects / Q000235:genetics / Q000276:immunology; D022223:Vaccines, Subunit / Q000009:adverse effects / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000235:genetics / Q000276:immunology; D054299:env Gene Products, Human Immunodeficiency Virus; D054322:tat Gene Products, Human Immunodeficiency Virus
D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D015686:Gene Products, env; D015696:Gene Products, tat; D015483:HIV Antibodies; D017778:Vaccines, Combined; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D054299:env Gene Products, Human Immunodeficiency Virus; C097729:gp140 envelope protein, Human immunodeficiency virus 1; D054322:tat Gene Products, Human Immunodeficiency Virus