Hematological malignancy manifesting as ascites.
BACKGROUND
A 63-year-old Caucasian woman presented with intermittent, left-sided abdominal discomfort without other symptoms. Physical examination revealed massive splenomegaly and complete blood counts showed thrombocytopenia. Splenectomy was recommended but the patient declined. She was lost to follow-up twice but returned with tense ascites about 2 years after the initial presentation. Despite aggressive medical management, the ascites did not improve.


METHODS
Bone-marrow and liver biopsies, abdominal ultrasound, esophagogastroduodenoscopy, abdominal CT scan and peripheral blood smear.


METHODS
Primary splenic lymphoma with hepatic infiltration causing portal hypertension and ascites.


RESULTS
Paracentesis, dietary sodium restriction and diuretics, splenectomy, splenorenal shunt and chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone).
Lazaridis
Konstantinos N
KN
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Abraham
Susan C
SC
Kamath
Patrick S
PS
D001201:Ascites / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D006971:Hypersplenism / Q000209:etiology* / Q000601:surgery; D006975:Hypertension, Portal / Q000209:etiology; D008875:Middle Aged; D013156:Splenectomy