Direct experimental observation of the effect of the base pairing on the oxidation potential of Guanine.
The effect of complementary base pairing on the oxidation potential of a guanosine derivative has been determined by cyclic and differential pulse voltammetry in CHCl3. The formation of the Watson-Crick H-bonded complex lowers the oxidation potential of the free molecule by 0.34 V, which compares well with the value obtained by DFT/B3LYP/6-311++g** computations.
Caruso
Tonino
T
Dipartimento di Chimica, Università di Salerno, via Salvador Allende, 43 Baronissi, Italy 84081.
Carotenuto
Maurizio
M
Vasca
Ermanno
E
Peluso
Andrea
A
D020029:Base Pairing; D004563:Electrochemistry / Q000379:methods; D006147:Guanine / Q000031:analogs & derivatives*; D009841:Oligonucleotides / Q000737:chemistry*; D010084:Oxidation-Reduction
D009841:Oligonucleotides; D006147:Guanine