Thrombocytopenia in HIV disease: clinical relevance, physiopathology and management.
HIV infection is associated with a myriad of hematopoietic abnormalities. Thrombocytopenia (TCP), the condition in which platelet counts fall below 150x10(3)/mm3 in two or more consecutive platelet counts, is a condition frequently seen in HIV infected individuals regardless of HIV status, gender, or age. Having recently been associated with rapid disease progression, and by complicating the management of AIDS patients, thrombocytopenia has become a medical challenge, highlighting the urgent need for evidence-based treatment protocols in this area. Due to the physiopathology of HIV, therapeutic options currently available for TCP in this already vulnerable population are severely limited. Whereas clinicians often intervene to prevent life-threatening, thrombocytopenia-associated outcomes in the general population, there is no intervention protocol: for the HIV subjects. Management of the condition seems to be the norm for these individuals. As a result, thrombocytopenia in HIV is a subject that is in urgent need of re-examination. In this review, the importance of thrombocytopenia and current knowledge regarding the physiopathology of HIV-associated thrombocytopenia is discussed, and an overview of current and under-investigation treatment approaches to this adverse hematological condition is provided.
Miguez-Burbano
M J
MJ
Division of Disease Prevention, Department of Psychiatry and Behavioral Sciences (D80), University of Miami-School of Medicine, 1400 N.W. 10th Avenue, 6th Floor, Miami, Florida 33136, USA. mmiguez@med.miami.edu
Jackson
J
J
Hadrigan
S
S
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001803:Blood Transfusion; D002648:Child; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D019290:Megestrol Acetate / Q000627:therapeutic use; D013156:Splenectomy; D013921:Thrombocytopenia / Q000150:complications* / Q000503:physiopathology / Q000628:therapy
D019380:Anti-HIV Agents; D016756:Immunoglobulins, Intravenous; D019290:Megestrol Acetate