title: Prophylactic antimicrobials for traveler's diarrhea: an early history.
abstract: The prevention of traveler's diarrhea by use of pharmacologic agents has been of great interest since the early 1960s. It was not until the discovery of enterotoxigenic Escherichia coli as the dominant causative organism of travelers' diarrhea, however, that rational antimicrobial therapy could be studied. Selected antimicrobials have proven to be highly efficacious, but, by consensus, are not widely used.
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. rsack@jhsph.edu
authors.forename: R Bradley
authors.initials: RB
authors.lastname: Sack
mesh_terms: D000900:Anti-Bacterial Agents / Q000266:history* / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology; D049673:History, 20th Century; D006801:Humans; D014195:Travel
chemical_list: D000900:Anti-Bacterial Agents