UV-photocrosslinking of inulin derivatives to produce hydrogels for drug delivery application.
In this work, INU, a natural polysaccharide, has been chemically modified in order to obtain new photocrosslinkable derivatives. To reach this goal, INU has been derivatized with MA thus obtaining four samples (INU-MA derivatives) as a function of the temperature and time of reaction. An aqueous solution of the derivative INU-MA1 was irradiated by using a UV lamp with an emission range from 250 to 364 nm and without using photoinitiators. The obtained hydrogel showed a remarkable water affinity but it underwent a partial degradation in simulated gastric fluid. To overcome this drawback, INU-MA1 was derivatized with SA thus obtaining the INU-MA1-SA derivative designed to produce a hydrogel showing a low swelling and an increased chemical stability in acidic medium. Ibuprofen, as a model drug, was loaded by soaking into INU-MA1 and INU-MA1-SA hydrogels and its release from these matrices was evaluated in simulated gastrointestinal fluids. INU-MA1 hydrogel showed the ability to quickly release the entrapped drug thus indicating its potential as a matrix for an oral formulation. INU-MA1-SA hydrogel showed a pH-responsive drug delivery. Therefore it is a promising candidate for controlled drug release in the intestinal tract.
Tripodo
Giuseppe
G
Dipartimento di Chimica e Tecnologie Farmaceutiche Università degli Studi di Palermo, Via Archirafi n.32, 90123-Palermo, Italy.
Pitarresi
Giovanna
G
Palumbo
Fabio Salvatore
FS
Craparo
Emanuela Fabiola
EF
Giammona
Gaetano
G
D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007444:Inulin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D010777:Photochemistry; D013386:Succinates / Q000138:chemical synthesis / Q000737:chemistry*; D014466:Ultraviolet Rays
D003692:Delayed-Action Preparations; D020100:Hydrogels; C507886:INU-MA1-SA; D013386:Succinates; D007444:Inulin