title: Meningeal solitary fibrous tumor: report of a case and literature review.
abstract: Solitary fibrous tumor is a rare neoplasm that most often involves the pleura. The increasing numbers of this neoplasm have also been reported to date in extrapleural sites. We report a case of a twenty-four-year-old female with right frontal mass. Histologically, the tumor composed of spindle cell proliferation. Tumor cells were found to be positive for CD34 and CD117 with immunohistochemical studies. Ten months follow-up was uneventful. Seventy seven cases of meningeal solitary fibrous tumor from the literature are analysed and pathological, immunohistochemical and clinical features are discussed. Solitary fibrous tumor has a slight female predominance, with a male to female ratio of 1:1.5. Age distribution is similar to meningioma ranging from 7-81 years. Approximately 23% of cases originate in the spine which is the most common meningeal location. Histopathologic examination shows uniform spindle cell proliferation with various amount of collagen. CD34-positivity usually allows discrimination from schwannomas, meningiomas and hemangiopericytomas. A differential diagnosis is important because most of the solitary fibrous tumors usually behave in a benign fashion. In this study, we also showed CD117 (Kit) expression in a case of meningeal SFT. CD117-positivity can be a good strategy for treatment in malignant and recurrent cases. Further investigations are necessary for therapeutic implication of CD117-positivity in SFT.
authors.affiliation: Department of Pathology, Erciyes University, Faculty of Medicine, Turkey. kdeniz@erciyes.edu.tr
authors.forename: Kemal
authors.initials: K
authors.lastname: Deniz
authors.forename: Olgun
authors.initials: O
authors.lastname: Kontas
authors.forename: Bulent
authors.initials: B
authors.lastname: Tucer
authors.forename: Ali
authors.initials: A
authors.lastname: Kurtsoy
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006393:Hemangiopericytoma / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000473:pathology; D018218:Neoplasms, Fibrous Tissue / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009442:Neurilemmoma / Q000473:pathology; D009455:Neurofibroma / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit