title: Investigations on gossypol: past and present developments.
abstract: Gossypol has received significant attention as a result of its potential therapeutic application as a male antifertility agent. Furthermore, recent research examining the biological activity of gossypol has revealed a number of other promising lines of enquiry. These have focused on the antitumour, antiviral and antioxidant actions of the compound in various disease states. This article provides an overview of the studies on the biological activity of gossypol, with particular attention paid to the mechanisms of its activity and its prospect as a medicinal product.
authors.affiliation: Sunderland Pharmacy School, University of Sunderland, Sunderland SR1 3SD, UK. kalliopi.dodou@sunderland.ac.uk
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Dodou
authors.forename: Rosaleen J
authors.initials: RJ
authors.lastname: Anderson
authors.forename: David A P
authors.initials: DA
authors.lastname: Small
authors.forename: Paul W
authors.initials: PW
authors.lastname: Groundwater
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects; D006072:Gossypol / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051336:Mitochondrial Membranes / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D006072:Gossypol