title: Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase.
abstract: A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series.
authors.affiliation: ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, PA 19341, USA. mlaporte@gentara.net
authors.forename: M G
authors.initials: MG
authors.lastname: Laporte
authors.forename: T A
authors.initials: TA
authors.lastname: Lessen
authors.forename: L
authors.initials: L
authors.lastname: Leister
authors.forename: D
authors.initials: D
authors.lastname: Cebzanov
authors.forename: E
authors.initials: E
authors.lastname: Amparo
authors.forename: C
authors.initials: C
authors.lastname: Faust
authors.forename: D
authors.initials: D
authors.lastname: Ortlip
authors.forename: T R
authors.initials: TR
authors.lastname: Bailey
authors.forename: T J
authors.initials: TJ
authors.lastname: Nitz
authors.forename: S K
authors.initials: SK
authors.lastname: Chunduru
authors.forename: D C
authors.initials: DC
authors.lastname: Young
authors.forename: C J
authors.initials: CJ
authors.lastname: Burns
mesh_terms: D018938:Caco-2 Cells; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000201:enzymology*; D006801:Humans; D008956:Models, Chemical; D017434:Protein Structure, Tertiary; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry* / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase