Superoxide anion-scavenging effect of 2-amino-1,3-selenazoles.
We investigated the superoxide anion scavenging effects of thirteen 2-amino-1,3-selenazoles using a highly sensitive quantitative chemiluminescence method. At 166 microM, the 2-amino-1,3-selenazoles scavenged in the range of 14.3 to 96.7% of O2-. 2-Piperidino-1,3-selenazole and 4-phenyl-2-piperidino-1,3-selenazole exhibited the strongest superoxide anion-scavenging activity among the 2-amino-1,3-selenazoles. The 50% inhibitory concentrations (IC50) of 2-piperidino-1,3-selenazole and 4-phenyl-2-piperidino-1,3-selenazole were determined to be 4.03 microM and 92.6 microM, respectively. Thus, these compounds acted in vitro as effective O2- scavengers.
Sekiguchi
Akihiro
A
Gunma Industrial Technology Center, Gunma, Japan.
Nishina
Atsuyoshi
A
Kimura
Hirokazu
H
Fukumoto
Ryo-hei
RH
Kanoh
Koichi
K
Ishihara
Hideharu
H
Koketsu
Mamoru
M
D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry*
D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D016566:Organoselenium Compounds; D013481:Superoxides