Hypoglycemia-induced anoxic brain injury possibly associated with levofloxacin.
Reports linking alterations in blood glucose concentrations with fluoroquinolones, mostly gatifloxacin and ciprofloxacin, have been published. We describe an elderly, non-diabetic patient with steroid-induced hyperglycemia prescribed glyburide who later developed severe hypoglycemia resulting in anoxic brain injury soon after initiating therapy with levofloxacin.
Lawrence
Kenneth R
KR
Department of Pharmacy and Division of Infectious Disease and Geographic Medicine, Tufts-New England Medical Center, 750 Washington Street, P.O. Box 420, Boston, MA 02111, USA. klawrence2@tufts-nemc.org
Adra
May
M
Keir
Christopher
C
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D015600:Glasgow Coma Scale; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced* / Q000150:complications*; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000209:etiology*; D064704:Levofloxacin; D008297:Male; D009460:Neurologic Examination; D015242:Ofloxacin / Q000009:adverse effects*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D064704:Levofloxacin; D015242:Ofloxacin