Effect of polycyclic cage amines on the transmembrane potential of neuronal cells.
A series of pentacycloundecylamine derivatives were synthesized and their influence on the transmembrane potential of human SH-SY5Y neuroblastoma cells was evaluated using laser scanning confocal microscopy in combination with the potentiometric dye tetramethylrhodamine methyl ester. Results indicate that these derivatives influence the profile of KCl-induced membrane depolarization and cause an overall reduction in cell membrane depolarization.
Grobler
Erika
E
Department of Pharmaceutical Chemistry, North-West University, Potchefstroom, South Africa.
Grobler
Anne
A
Van der Schyf
Cornelis J
CJ
Malan
Sarel F
SF
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003500:Cyclization; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
D000588:Amines