title: Multiple myeloma in 16 cats: a retrospective study.
abstract: BACKGROUND
  There is limited published information regarding feline multiple myeloma. Diagnostic criteria are derived from canine studies and to our knowledge, have not been critically reviewed for cats.
  
  
  OBJECTIVE
  To evaluate the clinical and laboratory findings in cats with multiple myeloma and appraise diagnostic criteria.
  
  
  METHODS
  Retrospective evaluation of medical records was performed. Inclusion required an antemortem diagnosis of multiple myeloma using 2 of 4 criteria: 1) >or=20% plasma cells in the bone marrow, or >or=10% if atypical plasma cells; 2) paraproteinemia; 3) radiographically-evident osteolysis; 4) light chain proteinuria. Alternatively, a postmortem diagnosis was based on the findings of multiple plasma cell neoplasms, with marrow involvement.
  
  
  RESULTS
  Sixteen cats were diagnosed with multiple myeloma between 1996 and 2004, with a median age of 14.0 years; 9 of 16 (56%) were castrated males, and 7 of 16 (44%) were spayed females. Laboratory abnormalities included hyperglobulinemia (14/16, 87.5%), with 11/14 (78.5%) monoclonal and 3/14 (21.4%) biclonal gammopathies; hypoalbuminemia (4/16, 25%); light chain proteinuria, (4/9, 44.4%); hypocholesterolemia (11/16, 68.7%); hypercalcemia, (3/15, 20%); nonregenerative anemia, (11/16, 68.7%); regenerative anemia, (1/16, 6.2%); neutropenia (5/15, 33.3%); thrombocytopenia (8/16, 50%); and marrow plasmacytosis (14/15, 93.3%). Plasma cells were markedly immature, atypical, or both in 10 of 12 (83.3%) cats. Focal or multifocal osteolysis was noted in 6 of 12 (50%) cats for which radiographs were available for review; generalized osteopenia was found in 1 (8.3%) cat. Noncutaneous, extramedullary tumors were found in all cats assessed, 7/7 (100%), including spleen (6), liver (3), and lymph nodes (4). The disease in 1 of 2 cats with cutaneous tumors progressed to plasmacytic leukemia.
  
  
  CONCLUSIONS
  Common findings in feline multiple myeloma include atypical plasma cell morphology, hypocholesterolemia, anemia, bone lesions, and multi-organ involvement. Based on the results of this study, we advocate modifying diagnostic criteria in cats to include consideration of plasma cell morphology and visceral organ infiltration.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Reema T
authors.initials: RT
authors.lastname: Patel
authors.forename: Ana
authors.initials: A
authors.lastname: Caceres
authors.forename: Adrienne F
authors.initials: AF
authors.lastname: French
authors.forename: Patricia M
authors.initials: PM
authors.lastname: McManus
mesh_terms: D000745:Anemia, Hemolytic, Congenital / Q000473:pathology / Q000662:veterinary; D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology; D002415:Cats; D005260:Female; D007952:Leukemia, Plasma Cell / Q000473:pathology / Q000662:veterinary; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010014:Osteolysis / Q000473:pathology / Q000662:veterinary; D010265:Paraproteinemias / Q000473:pathology / Q000662:veterinary; D010950:Plasma Cells / Q000473:pathology; D010954:Plasmacytoma / Q000473:pathology / Q000662:veterinary; D012189:Retrospective Studies