title: [Expression and significance of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the clinical implication and the expression of CD44v6 and MMP-9 protein in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  Twenty-seven samples of LSCC and eight biopsies of adjacent non-cancerous tissue were detected with immunohistochemical technique (SABC method). The relationship between positive expression of CD44v6 or MMP-9 in LSCC and invasion or metastasis was analyzed.
  
  
  RESULTS
  Both CD44v6 and MMP-9 overexpressed in LSCC. The positive expression of CD44v6 was correlated with LSCC pathologic grade, cervical lymph node metastasis and postoperation survival rate (P < 0.05). The expression of MMP-9 was positively correlated with clinical staging and cervical lymph node metastasis (P < 0.05). There was a significant positive correlation between the expression of CD44v6 and MMP-9 (P < 0.01).
  
  
  CONCLUSIONS
  There is a relationship between the expression of CD44 and MMP-9. CD44v6 and MMP-9 might be served as an objective indicator for lymph nodal metastatic potency, tumor invasion and prognosis in LSCC.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China. qin-lzm@tom.com
authors.forename: Gang
authors.initials: G
authors.lastname: Qin
authors.forename: Wanrong
authors.initials: W
authors.lastname: Li
authors.forename: Xingwang
authors.initials: X
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Zhengnong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: C112697:CD44v6 antigen; D018960:Hyaluronan Receptors; D020780:Matrix Metalloproteinase 9