title: Effects of acepromazine on three-phase 99mTc-MDP bone imaging in 11 horses.
abstract: Horses undergoing skeletal scintigraphy can have decreased radiopharmaceutical bone uptake in the limbs. This reduces the diagnostic value of the scan. The aim of the present study was to measure the changes in count density caused by vasodilatation and increased blood flow associated with intravenous injection of acepromazine during bone scintigraphy in normal horses. A three-phase bone scan was performed twice in 11 adult horses to study the effects of acepromazine on the count density of the resultant scintigrams. With acepromazine, there was a statistically significant mean difference of 12 s for initial blood flow and 21 s for peak flow. The time to initial blood flow and time to peak flow occurred earlier for the scans in which acepromazine was used. There were no significant differences in the bone to soft tissue ratios during the soft tissue and bone phases of the scan between procedures. Intravenous administration of acepromazine increases peripheral blood flow causing an earlier onset of the vascular phase during the three-phase bone scan. Acepromazine did not increase the count density of the bone phase scintigrams. As expected, the vasodilatation and increased blood flow associated with intravenous injection of acepromazine affected the count density of the vascular phase of the bone scan.
authors.affiliation: Department of Clinical Sciences, Tufts University, School of Veterinary Medicine, North Grafton, MA 01536, USA. Mauricio.solano@tufts.edu
authors.forename: Mauricio
authors.initials: M
authors.lastname: Solano
authors.forename: Jeremy
authors.initials: J
authors.lastname: Welcome
authors.forename: Karen
authors.initials: K
authors.lastname: Johnson
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006736:Horses / Q000378:metabolism* / Q000502:physiology; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D011877:Radionuclide Imaging / Q000662:veterinary; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011884:Radius / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014457:Ulna / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D000075:Acepromazine