[Clinical and pathological analysis of oral manifestations of 40 patients with secondary syphilis].
OBJECTIVE
To analyze the clinical and pathological features of 40 patients with secondary syphilis.


METHODS
A total of 40 cases of secondary syphilis confirmed by serology were collected during 1994-2004 and were first diagnosed on presentation with oral lesions.


RESULTS
The white patch in oral mucosa was found in 32 cases with painless or slight pain in most cases. The most common site of the lesion was the tongue. The histological examination on eight cases was initially misdiagnosed as oral candidosis or lichen planus, but confirmed as syphilis after serology revealed nonspecific inflammation with intraepithelial microabscess and dense perivascular infiltration of lymphocytes and plasma cells in connective tissue. The symptoms showed dramatic improvement in 16 cases after benzathine penicillin treatment.


CONCLUSIONS
The oral manifestations of syphilis have specific clinical and pathological feature and attention should be paid to the suspicious oral lesions when patients are first presented in a dental office.
Hua
Hong
H
Deaprtment of Oral Medicine, Peking University School of Stomatology, Beijing 100081, China. honghua1968@yahoo.com.cn
Yan
Zhi-min
ZM
Shi
Rui-tang
RT
Gao
Yan
Y
Xu
Yan-ying
YY
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D019226:Oral Ulcer / Q000209:etiology; D013587:Syphilis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*