[Effect of rapid and slow cooling on thermoregulatory responses in hypertensive and normotensive rats after calcium administration].
The effect of iontophoretic administration of calcium ions to skin in the area of cold stimulus application on the thermal thresholds and the magnitude of cold defense responses in normotensive Wistar and hypertensive ISIAH rats was studied. In thermoneutral conditions, administration of calciumions wos without effect on the measured thermoregulatory parameters. Under the effect of calcium, the thresholds of all the thermoregulatory responses to cooling (such as heat loss, oxygen consumption, shivering) are lowered and the values of heat loss and shivering thermogenesis are considerably increased. The effects of calcium on thermoregulatory responses depend on the rate of cooling. All changes are more expressive in hypertensive rats. The increased sensitivity of hypertensives to calcium suggests that change in their calcium metabolism may be a cause of the observed shifts in the thermoregulatory response to cold.
Kozyreva
T V
TV
Lomakina
S V
SV
Tkachenko
E Ia
EIa
Markel'
A L
AL
D000818:Animals; D001831:Body Temperature; D001833:Body Temperature Regulation; D002118:Calcium / Q000008:administration & dosage / Q000378:metabolism*; D003080:Cold Temperature / Q000009:adverse effects*; D004594:Electrophysiology; D006973:Hypertension / Q000503:physiopathology; D007036:Hypothermia, Induced; D007478:Iontophoresis; D009334:Neck Muscles / Q000502:physiology; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D012881:Skin Temperature; D014661:Vasoconstriction
D002118:Calcium