Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase.
Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a hydrogen bonding donor is essential for inhibitory activity.
Moon
Hyung Ryong
HR
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Lee
Kang Man
KM
Lee
Joo Hyun
JH
Lee
Sang Kook
SK
Park
Seung Bin
SB
Chun
Moon Woo
MW
Jeong
Lak Shin
LS
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000998:Antiviral Agents / Q000494:pharmacology; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D013329:Structure-Activity Relationship; D013696:Temperature
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; C031096:neplanocin A; D006859:Hydrogen; D043383:Adenosylhomocysteinase; D000241:Adenosine