Individual and simultaneous spectrophotometric determination of dapsone and metoclopramide HCl in pharmaceutical dosage forms and synthetic binary mixtures.
A rapid, sensitive and selective spectrophotometric method has been developed for the quantitative determination of dapsone (DAP) and metoclopramide hydrochloride (MCP) in both pure and dosage forms. Individual and simultaneous methods are based on the diazo coupling reaction of these drugs with benzoylacetone (BAC) in alkaline medium. The resulting azo dyes exhibit maximum absorption at 437 and 411 nm with a molar absorptivity of 4.14x10(4) and 2.97x10(4) l mol-1 cm-1 for DAP and MCP, respectively. Simultaneous determination of DAP and MCP was developed utilizing first-order digital derivative spectrophotometry. All variables have been optimized. No interferences were observed from drug excipients and the validity of the methods was tested against reference methods.
Omran
Ahmed Ahmed
AA
Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, Egypt. ahmed_omran@yahoo.com
D000932:Antiemetics / Q000032:analysis*; D002074:Butanones / Q000737:chemistry; D003622:Dapsone / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007917:Leprostatic Agents / Q000032:analysis*; D008787:Metoclopramide / Q000032:analysis*; D019999:Pharmaceutical Solutions; D012015:Reference Standards; D012977:Sodium Nitrite; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000932:Antiemetics; D002074:Butanones; D007202:Indicators and Reagents; D007917:Leprostatic Agents; D019999:Pharmaceutical Solutions; D013607:Tablets; D003622:Dapsone; C035851:benzoylacetone; D008787:Metoclopramide; D012977:Sodium Nitrite