Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains.
The brain neurotransmitter serotonin is involved in the regulation of aggressive behavior. The main factor determining the brain serotonin level is the activity of the rate-limiting enzyme in the biosynthesis of the neurotransmitter--tryptophan hydroxylase isoform (TPH) 2 encoded by the Tph2 gene. Recently the C1473G single-nucleotide polymorphism in the Tph2 gene was reported. Here we study the C1473G polymorphism in 10 inbred mouse strains (C57BL/6J, AKR/J, DD/He, C3H/HeJ, YT/Y, BALB/cJLac, CC57BR/Mv and A/He) and demonstrate the association of the polymorphism with brain TPH activity and intermale aggressiveness. TPH activity in the midbrain of mice homozygous for the 1473C allele was higher than that in mice carrying 1473G alleles. A close association of the 1473C allele with increased number of attacks towards another male was found. The results support a link between the C1473G polymorphism in Tph2 gene, tryptophan hydroxylase activity and intensity of intermale aggression.
Kulikov
A V
AV
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, ave. Lavryentyev 10, 630090 Novosibirsk, Russia. akulikov@ngs.ru
Osipova
D V
DV
Naumenko
V S
VS
Popova
N K
NK
D000374:Aggression / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013045:Species Specificity; D018709:Statistics, Nonparametric; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000502:physiology
C487802:Tph2 protein, mouse; D014365:Tryptophan Hydroxylase