Acute hepatitis and atovaquone/proguanil.
A 31-year-old healthy man developed acute hepatitis after receiving atovaquone (250 mg) and proguanil (100 mg) for malaria prophylaxis daily for 25 days. Although atovaquone/proguanil is generally well-tolerated, this case highlights the hepatotoxic potential with considerable morbidity and should alert physicians to this harmful side effect.
Grieshaber
Matthias
M
Department of Opthamology, Medical University of Southern Africa, Medunsa, South Africa.
Lämmli
Jürg
J
Marcus
Louis
L
D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D053626:Atovaquone; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D009285:Naphthoquinones / Q000009:adverse effects*; D002727:Proguanil / Q000009:adverse effects*
D000962:Antimalarials; D009285:Naphthoquinones; D002727:Proguanil; D053626:Atovaquone