Evaluation of mitomycin C in reducing postoperative adhesions in strabismus surgery.
OBJECTIVE
The aim of this study was to evaluate the efficacy of mitomycin C in reducing postoperative adhesions following strabismus surgery.


METHODS
This study was a prospective, single-center, interventional case series. We randomized 14 patients with restrictive strabismus to the mitomycin C group (7 patients) or to the control group (7 patients). We used mitomycin C intraoperatively for 5 min at a concentration of 0.2 mg/mL in the mitomycin group after adhesion release. We compared postoperative results using the forced duction test.


RESULTS
Compared to the control group, the mitomycin C group exhibited a better range of passive duction at all postoperative follow-up times; however, mitomycin C did not completely eliminate the problem of postoperative adhesions. Patients receiving mitomycin C did not report any complications during this study.


CONCLUSIONS
The intraoperative application of mitomycin C is a safe and effective adjunct to surgery in the treatment of restrictive strabismus.
Chen
Po-Liang
PL
Department of Ophthalmology, Tri-Service General Hospital, Taipei, Taiwan, Republic of China. ddff36@yahoo.com.tw
Chen
Wan-Ying
WY
Lu
Da-Wen
DW
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions
D016685:Mitomycin