Centrosome maturation: Aurora lights the way to the poles.
The centrosome is the main microtubule organising centre in the cell. During mitosis, centrosomes dramatically increase microtubule nucleating activity, enabling them to form a mitotic spindle. Recent studies show that Aurora A kinase promotes microtubule assembly from centrosomes through the phosphorylation of the conserved centrosomal protein TACC.
Brittle
Amy L
AL
Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, UK.
Ohkura
Hiroyuki
H
D064127:Aurora Kinases; D018385:Centrosome / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D008941:Spindle Apparatus / Q000502:physiology
D064127:Aurora Kinases; D029721:Drosophila Proteins; D008869:Microtubule-Associated Proteins; D017346:Protein Serine-Threonine Kinases; C404402:TACC protein, Drosophila