title: Prognostic factors in head and neck adenoid cystic carcinoma.
abstract: The aim of this study was to analyse the clinical, histological and immunohistochemical prognostic factors of a large series of adenoid cystic carcinoma, using univariate and multivariate survival analyses. All cases of head and neck ACC (n = 129) treated in a single institution in Brazil, between 1955 and 1997, were selected for the study. Univariate survival analysis revealed that age older than 45 years (p = 0.04), period of complaints inferior to 18 months (p = 0.007), presence of paresthesia (p = 0.04), T stage (p = 0.01), N stage (p = 0.04), M stage (p < 0.001), clinical stage (p = 0.003), solid histological type ( p< 0.001), presence of residual tumor (p < 0.001) and expression of p53 (p = 0.08) correlated with a poor prognosis. In the multivariate survival analyses, clinical stage, solid histological subtype and increased expression of p53 were independent significant prognostic factors. According to our findings, clinical stage, solid growth pattern and expression of p53 were the most important prognostic factors in patients with ACC.
authors.affiliation: Oral Pathology Division, School of Dentistry of Piracicaba, State University of Campinas (UNICAMP); Av. Limeira, 901, Areão, CEP: 13414-903, Piracicaba/SP, Brazil. perezdec2003@yahoo.com.br
authors.forename: Danyel Elias
authors.initials: DE
authors.lastname: da Cruz Perez
authors.forename: Fábio
authors.initials: F
authors.lastname: de Abreu Alves
authors.forename: Inês
authors.initials: I
authors.lastname: Nobuko Nishimoto
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.forename: Luiz Paulo
authors.initials: LP
authors.lastname: Kowalski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53