[Particular features of the treatment of ulcer recurrence in patients with myocardial infarction].
107 patients with myocardial infarction and ulcer recurrence were examined. It was revealed that the ulcerous process proceeded with focal trombohemorragic disorders of local microcirculation in the gastroduodenal mucous coat in severe cases of myocardial infarction and with tromboischemic disorders of terminal blood flow in extremely severe cases. It was accompanied by the activation of acid and pepsin production, depression of mucopolysaccharides production and hypermotor gastric dyskinesis in patients with severe coronary pathology, in patients with the extremely severe pathology--by the depression of all functions of the stomach, except for normal acid production. The administration of an antiulcerous therapy helped to reduce the period of elimination of ulcer recurrence symptoms, liquidated microcirculatory and gastric functional disorders, and promoted the healing of ulcers. The therapy included omeprazole, sucralfate, long-term form of nifedipine for patients with severe myocardial infarction, and ranitidine, sucralfate and doxazosin in common doses for 20-25 days for patients with extremely severe cases.
Osadchiĭ
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VA
D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000473:pathology; D009203:Myocardial Infarction / Q000150:complications*; D055502:Secondary Prevention; D013276:Stomach Ulcer / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D014665:Vasodilator Agents