A six-step asymmetric synthesis of (+)-hyperaspine.
[reaction: see text] The ladybird alkaloid, (+)-hyperaspine, has been synthesized in a concise and highly stereoselective manner. The total synthesis was accomplished in six steps and 21% overall yield.
Comins
Daniel L
DL
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA. daniel_comins@ncsu.edu
Sahn
James J
JJ
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D010880:Piperidines; D011807:Quinolizines; C512011:hyperaspine