Deficits in sexual and aggressive behaviors in Cnga2 mutant mice.
Odors detected by the vomeronasal organ or the main olfactory epithelium (MOE) trigger social behaviors in many animals. It is unknown whether MOE neurons detect cues that initiate mating or aggression. We demonstrate that mice lacking functional CNGA2 (cyclic nucleotide-gated channel alpha2), which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors.
Mandiyan
Vidya S
VS
Neuroscience Graduate Program, Department of Anatomy, Box 2722, University of California San Francisco, San Francisco, California 94143, USA.
Coats
Jennifer K
JK
Shah
Nirao M
NM
D000374:Aggression / Q000502:physiology*; D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels; D005260:Female; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009490:Neurosecretory Systems / Q000502:physiology; D009830:Olfactory Bulb / Q000502:physiology; D009831:Olfactory Mucosa / Q000378:metabolism*; D009833:Olfactory Pathways / Q000502:physiology; D010675:Pheromones / Q000502:physiology*; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000502:physiology*; D012903:Smell / Q000235:genetics*; D009435:Synaptic Transmission / Q000502:physiology; D019147:Vomeronasal Organ / Q000502:physiology
D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels; D010675:Pheromones