title: Frequent expression of neuroendocrine markers in mucinous tubular and spindle cell carcinoma of the kidney.
abstract: Mucinous tubular and spindle cell carcinoma (MTSCC) is a new tumorous entity which has been recently established. In this article, we examined the expression of neuroendocrine markers including neuron specific enolase (NSE), chromogranin A and synaptophysin in 16 cases of MTSCC using immunohistochemistry. The sex ratio (male: female) of the patients was 4:12. In normal kidney, distal tubules or collecting ducts were positive for NSE, but no structures were positive for chromogranin A or synaptophysin. All MTSCCs showed a positive reaction for NSE. Additionally, fifteen of sixteen neoplasms (93.8%) with MTSCC showed the expression of either chromogranin A or synaptophysin or both. Finally, it is possible that MTSCC may be one of renal neoplasms which frequently exhibit the neuroendocrine differentiation.
authors.affiliation: Department of Pathology, Kochi Medical School, Kochi University, Japan. nkuroda@med.kochi-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Kuroda
authors.forename: O
authors.initials: O
authors.lastname: Hes
authors.forename: E
authors.initials: E
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Shuin
authors.forename: H
authors.initials: H
authors.lastname: Enzan
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D049109:Cell Proliferation; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis*; D016708:Synaptophysin / Q000032:analysis*
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase