title: [Progress on genetic susceptibility to ankylosing spondylitis].
abstract: Ankylosing spondylitis (AS) is a highly heritable, common inflammatory rheumatic disease. Since 1970s, evidence has increasingly pointed to HLA-B27 as the major gene involved in susceptibility to AS. However, genome-wide scan and association studies have shown, in addition to HLA, regions outside the HLA are involved in susceptibility to AS. Furthermore, there is compelling evidence that non-B27 genes, either within or outside the HLA, are involved in disease aetiology. This review mainly summarized different genes associated with AS, and the current progress in this exciting area.
authors.affiliation: Institute of Medical Biotechnology & Molecular Genetics, Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China. rwchen@smmu.edu.cn
authors.forename: Rui-Wen
authors.initials: RW
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Shu-Han
authors.initials: SH
authors.lastname: Sun
authors.forename: Shi-Wei
authors.initials: SW
authors.lastname: Duan
mesh_terms: D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D015810:Linkage Disequilibrium; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D015235:HLA-B Antigens; D007375:Interleukin-1; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D019389:Cytochrome P-450 CYP2D6