Verbal and spatial working memory in autism.
Verbal and spatial working memory were examined in high-functioning children, adolescents, and adults with autism compared to age and cognitive-matched controls. No deficit was found in verbal working memory in the individuals with autism using an N-back letter task and standardized measures. The distinction between the N-back task and others used previously to infer a working memory deficit in autism is that this task does not involve a complex cognitive demand. Deficits were found in spatial working memory. Understanding the basis for the dissociation between intact verbal working memory and impaired spatial working memory and the breakdown that occurs in verbal working memory as information processing demands are increased will likely provide valuable insights into the neural basis of autism.
Williams
Diane L
DL
School of Medicine, University of Pittsburgh, PA 15213, USA.
Goldstein
Gerald
G
Carpenter
Patricia A
PA
Minshew
Nancy J
NJ
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000453:epidemiology* / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D008606:Mental Processes; D008875:Middle Aged; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D013028:Space Perception; D014705:Verbal Behavior