title: Gene expression microarray data analysis of decidual and placental cell differentiation.
abstract: Gene expression analysis using DNA microarray approaches have provided new insights into the physiology and pathophysiology of many biological processes. These include identification of genetic programs and pathways that underlie cell and tissue differentiation and gene expression programs responsive to genetic perturbations, drugs, toxins, and infectious agents. In this chapter, we present methods for the analysis of microarray data using earlier investigations from our laboratory as examples of how gene expression patterns for cellular differentiation may be detected and analyzed for biological significance and how regulated genes may be classified into functional categories and pathways.
authors.affiliation: Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Sue
authors.initials: S
authors.lastname: Kong
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Aronow
authors.forename: Stuart
authors.initials: S
authors.lastname: Handwerger
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D016000:Cluster Analysis; D003656:Decidua / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D015345:Oligonucleotide Probes; D010920:Placenta / Q000166:cytology* / Q000378:metabolism*
chemical_list: D015345:Oligonucleotide Probes