title: Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.
abstract: Phosphoglucomutase catalyses the reversible conversion of glucose-6-P and glucose-1-P. Lithium is a potent inhibitor of phosphoglucomutase in vitro, however, it is not known if phosphoglucomutase was significantly inhibited by Li+ in Li+-treated bipolar patients. Here, we demonstrate that phosphoglucomutase inhibition by chronic Li+ treatment causes alterations of glucose-phosphate levels in various tissues of rats. Also, phosphoglucomutase inhibition results in compensatory elevation of phosphoglucomutase activity in rat tissues and in leukocytes isolated from Li+-treated bipolar patients. The increase of uninhibited phosphoglucomutase activity in leukocytes of Li+-treated bipolar patients is due to the increased expression of the PGM1 gene.
authors.affiliation: Department of Laboratory Medicine, Pécs University, Pécs, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Csutora
authors.forename: Arpád
authors.initials: A
authors.lastname: Karsai
authors.forename: Tamás
authors.initials: T
authors.lastname: Nagy
authors.forename: Bálint
authors.initials: B
authors.lastname: Vas
authors.forename: Gábor
authors.initials: G
authors.lastname: L Kovács
authors.forename: Orsolya
authors.initials: O
authors.lastname: Rideg
authors.forename: Péter
authors.initials: P
authors.lastname: Bogner
authors.forename: Attila
authors.initials: A
authors.lastname: Miseta
mesh_terms: D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002118:Calcium / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D018021:Lithium Chloride / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010733:Phosphoglucomutase / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D018692:Antimanic Agents; D005958:Glucosephosphates; D012333:RNA, Messenger; D019298:Glucose-6-Phosphate; C031590:glucose-1-phosphate; D010733:Phosphoglucomutase; D018021:Lithium Chloride; D008274:Magnesium; D002118:Calcium