title: Association between quality of life scores and short-term outcome after surgery for cancer of the oesophagus or gastric cardia.
abstract: BACKGROUND
  Evidence suggests that baseline quality of life (QOL) scores are independently prognostic for survival in patients with cancer, but the role of QOL data in predicting short-term outcome after surgery is uncertain. This study assessed the association between QOL scores and short-term outcomes after surgery for oesophageal and gastric cancer.
  
  
  METHODS
  Consecutive patients selected for oesophagectomy or total gastrectomy between November 2000 and May 2003 completed the European Organization for Research and Treatment of Cancer's quality of life questionnaire, QLQ-C30. Multivariable regression models, adjusting for known clinical risk factors, were used to investigate relationships between QOL scores, major morbidity, hospital stay and survival status at 6 months.
  
  
  RESULTS
  Of 130 patients, 121 completed the questionnaire (response rate 93.1 per cent). There were 29 major complications (24.0 per cent) and 22 patients (18.2 per cent) died within 6 months of operation. QOL scores were not associated with major morbidity but were significantly related to survival status at 6 months after adjusting for known clinical risk factors. A worse fatigue score of 10 points (scale 0-100) corresponded to an increase in the odds of death within 6 months of surgery of 37.4 (95 per cent confidence interval (c.i.) 12.4 to 67.8) per cent (P = 0.002). Pretreatment social function scores were moderately associated with hospital stay (P = 0.021); a reduction in social function by 10 points corresponded to an increase in hospital stay of 0.93 (95 per cent c.i. 0.12 to 1.74) days.
  
  
  CONCLUSIONS
  QOL scores supplement standard staging procedures for oesophageal and gastric cancer by providing prognostic information, but they do not contribute to perioperative risk assessment.
authors.affiliation: Surgery Level 7, Clinical Sciences at South Bristol, Bristol BS2 8HW, UK. j.m.blazeby@bristol.ac.uk
authors.forename: J M
authors.initials: JM
authors.lastname: Blazeby
authors.forename: C
authors.initials: C
authors.lastname: Metcalfe
authors.forename: J
authors.initials: J
authors.lastname: Nicklin
authors.forename: C P
authors.initials: CP
authors.lastname: Barham
authors.forename: J
authors.initials: J
authors.lastname: Donovan
authors.forename: D
authors.initials: D
authors.lastname: Alderson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002299:Cardia / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods; D005260:Female; D005743:Gastrectomy / Q000379:methods; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000601:surgery*; D016896:Treatment Outcome