Effect of ME-3451-106, an aqueous extract of Stichaster striatus with inhibitory activity of voluntary alcohol intake, in genetically drinker rats: Isolation and identification of the active fraction.
The aqueous extract obtained from Stichaster striatus Müller & Troschel (Asteroidea, Stichasteridae) has been shown to possess activity as an alcohol appetite inhibitor after oral administration in a rat model with a genetically established excessive appetite for alcohol (Wistar rats, lineage UChB). A significant decrease in the consumption of ethanol was observed (unrelated to a possible disulfiram effect) without a change in the normal food or water intake during the experimentation period. A bio-guided fractionation of the extract was carried out in order to identify the most active fraction, in which the presence of a group of natural endogenous polyamines in undetermined proportions is suspected. Our hypothesis was to relate the activity obtained for the original ME-3451-106 extract with the presence of these polyamines in the extract in question. The activity shown by a series of commercially available polyamines (putrescine (Pu), spermidine (SPD) and spermine (SP)) in inhibiting voluntary ethanol intake lends support to our hypothesis. The extract was selected on the basis of oral tradition, which claimed that the consumption of a "soup" obtained by boiling starfish, later identified as Stichaster striatus, prevented the appearance of alcoholism in laborers on properties entrusted to the Jesuit order during the middle period of the Spanish conquest of America (17-18th century).
Font
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Molecular Modeling Unit, Department of Organic and Medicinal Chemistry, University of Navarra, Irunlarrea no. 1, 31008 Pamplona, Spain. mfont@unav.es
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Contreras
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Paeile
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García
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D000427:Alcohol Deterrents / Q000494:pharmacology*; D000428:Alcohol Drinking / Q000235:genetics; D000818:Animals; D001688:Biological Products / Q000494:pharmacology*; D051381:Rats; D013215:Starfish / Q000737:chemistry*
D000427:Alcohol Deterrents; D001688:Biological Products