title: Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages.
abstract: An in-depth study into the incorporation of multiple 3-S-phosphorothiolate modifications into oligodeoxynucleotides (ODNs) and their subsequent effect on ODN/DNA and ODN/RNA duplex stability. 3-S-Phosphorothiolate linkages increase the stability of ODN/RNA duplexes and decrease the stability of ODN/DNA duplexes.
authors.affiliation: Department of Chemistry, University of Liverpool, Crown St, Liverpool L69 7ZD, UK. joannebuckingham@yahoo.co.uk
authors.forename: Joanne
authors.initials: J
authors.lastname: Buckingham
authors.forename: Ghalia
authors.initials: G
authors.lastname: Sabbagh
authors.forename: John
authors.initials: J
authors.lastname: Brazier
authors.forename: Julie
authors.initials: J
authors.lastname: Fisher
authors.forename: Rick
authors.initials: R
authors.lastname: Cosstick
mesh_terms: D004247:DNA / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013696:Temperature; D013816:Thermodynamics; D013873:Thionucleotides / Q000737:chemistry*
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D013873:Thionucleotides; D010758:Phosphorus; D012313:RNA; D004247:DNA