title: Combined neurolytic block of celiac, inferior mesenteric, and superior hypogastric plexuses for incapacitating abdominal and/or pelvic cancer pain.
abstract: Thirty-five patients with extensive abdominal or pelvic cancer who suffered uncontrolled, diffuse, extensive, and incapacitating pain were treated with a combination of neurolytic celiac plexus block (CPB), inferior mesenteric plexus block (IMPB), and superior hypogastric plexus block (SHGPB). The combination of neurolytic CPB, IMPB, and SHGPB was performed with alcohol, mainly using a transintervetebral disc approach. The combination neurolysis produced effective immediate pain relief in all the patients (visual analog scale (VAS), reduced from 8.8 +/- 0.2 to 0). This pain relief persisted during the first 3 months (VAS, 2.3 +/- 0.5) or until death. Morphine consumption was significantly decreased for the first 1 month (from 96 +/- 29 mg to 31 +/- 10 mg per day) after the neurolysis and thereafter continued to be lower than before the surgery, though not significantly so. No serious complications were observed to have been caused by the neurolytic procedure on the three sympathetic plexuses. Our preliminary clinical results suggest that the combination of neurolytic CPB, IMPB, and SHGPB improves the quality of life of patients who have incapacitating cancer pain, by reducing both the intensity of the pain and their opioid consumption, without serious complications. This combination procedure may provide a new therapeutic option for pain relief in patients with advanced cancer.
authors.affiliation: Department of Anesthesia, Nagano Municipal Hospital, 1331-1 Tomitake, Nagano 381-8551, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitoh
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Koichi
authors.initials: K
authors.lastname: Ono
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ohfusa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ina
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Otagiri
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy*; D015746:Abdominal Pain / Q000188:drug therapy / Q000209:etiology; D000701:Analgesics, Opioid; D002447:Celiac Plexus; D002492:Central Nervous System Depressants / Q000627:therapeutic use*; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007001:Hypogastric Plexus; D008297:Male; D008643:Mesentery / Q000294:innervation; D009020:Morphine; D009407:Nerve Block; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D010386:Pelvic Neoplasms / Q000188:drug therapy*; D017699:Pelvic Pain / Q000188:drug therapy / Q000209:etiology; D011788:Quality of Life
chemical_list: D000701:Analgesics, Opioid; D002492:Central Nervous System Depressants; D000431:Ethanol; D009020:Morphine