Fluoroquinolone-resistant Vibrio cholerae isolated during a cholera outbreak in India.
During the cholera epidemic of 2002 in and around Hubli, south India, Vibrio cholerae strains resistant to fluoroquinolones were isolated. Among the isolates of V. cholerae non-O1, non-O139 serogroups, 55.9% and 47.1% were resistant to norfloxacin and ciprofloxacin, respectively. However, only 12.5% of the O1 serogroup strains were resistant to both norfloxacin and ciprofloxacin. Though the O139 serogroup strains were susceptible to these antibiotics, they exhibited multidrug resistance. Emergence of fluoroquinolone-resistant V. cholerae that also exhibited multidrug resistance is of great significance in the epidemiology and control of cholera.
Krishna
B V S
BV
Department of Microbiology, Karnataka Institute of Medical Sciences, Hubli 580022, India. bvsk@yahoo.com
Patil
Asha B
AB
Chandrasekhar
M R
MR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology; D002939:Ciprofloxacin / Q000627:therapeutic use; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use; D014734:Vibrio cholerae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D009643:Norfloxacin