Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice.
In the present paper, we describe the analgesic effects induced by the transient receptor potential vanilloid type 1 (TRPV1) antagonist, capsazepine, and the TRPV1 agonist, resiniferatoxin, on the thermal hyperalgesia induced by the presence of a tibial osteosarcoma or an inflammatory process in mice. The administration of capsazepine abolished the osteosarcoma-induced hyperalgesia at a dose range (3-10 mg/kg; s.c.) ineffective to inhibit the hyperalgesia elicited by the intraplantar administration of complete Freund's adjuvant (CFA). In contrast, the administration of resiniferatoxin (0.01-0.1 mg/kg; s.c.) inhibited both the osteosarcoma- and the CFA-induced hyperalgesia. Remarkably, a single dose of resiniferatoxin abolished the osteosarcoma-induced hyperalgesia for several days and completely prevented the instauration of thermal hyperalgesia when administered at the initial stages of osteosarcoma development. The potential of drugs acting through TRPV1 for the management of some types of bone cancer pain is proposed.
Menéndez
Luis
L
Laboratorio de Farmacología, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, IUOPA, Universidad de Oviedo, C/ Julián Clavería 6, 33006 Oviedo, Spain. luismen@uniovi.es
Juárez
Lucía
L
García
Eva
E
García-Suárez
Olivia
O
Hidalgo
Agustín
A
Baamonde
Ana
A
D000700:Analgesics / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D001859:Bone Neoplasms / Q000150:complications*; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002460:Cell Line; D004195:Disease Models, Animal; D004224:Diterpenes / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005620:Freund's Adjuvant; D007839:Functional Laterality; D007249:Inflammation / Q000139:chemically induced; D051379:Mice; D008809:Mice, Inbred C3H; D012516:Osteosarcoma / Q000150:complications / Q000209:etiology; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000379:methods; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D004224:Diterpenes; D005620:Freund's Adjuvant; C024353:resiniferatoxin; C071423:capsazepine; D002211:Capsaicin