Normal and transforming functions of RUNX1: a perspective.
Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.
Mikhail
Fady M
FM
Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Sinha
Kislay K
KK
Saunthararajah
Yogen
Y
Nucifora
Giuseppina
G
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics
D050676:Core Binding Factor Alpha 2 Subunit