title: Expression of chondrogenic potential of mouse trunk neural crest cells by FGF2 treatment.
abstract: There is a significant difference between the developmental patterns of cranial and trunk neural crest cells in the amniote. Thus, whereas cranial neural crest cells generate bone and cartilage, trunk neural crest cells do not contribute to skeletal derivatives. We examined whether mouse trunk neural crest cells can undergo chondrogenesis to analyze how the difference between the developmental patterns of cranial and trunk neural crest cells arises. Our present data demonstrate that mouse trunk neural crest cells have chondrogenic potential and that fibroblast growth factor (FGF) 2 is an inducing factor for their chondrogenesis in vitro. FGF2 altered the expression patterns of Hox9 genes and Id2, a cranial neural crest cell marker. These results suggest that environmental cues may play essential roles in generating the difference between developmental patterns of cranial and trunk neural crest cells.
authors.affiliation: Department of Biology, Graduate School of Science, Osaka University, Osaka, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ido
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ito
mesh_terms: D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D020219:Chondrogenesis / Q000187:drug effects*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D051797:Inhibitor of Differentiation Protein 2 / Q000235:genetics; D051379:Mice; D009432:Neural Crest / Q000166:cytology / Q000187:drug effects* / Q000196:embryology* / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C497452:Idb2 protein, mouse; D051797:Inhibitor of Differentiation Protein 2; D017468:Receptors, Fibroblast Growth Factor; D014157:Transcription Factors; D016222:Fibroblast Growth Factor 2