Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile.
[reaction: see text] A new, mild, and reversible method to convert primary amides to nitriles in good yields using PdCl2 in aqueous acetonitrile is described.
Maffioli
Sonia I
SI
Vicuron Pharmaceuticals, via R. Lepetit 34, Gerenzano (VA), Italy. smaffioli@vicuron.it
Marzorati
Ettore
E
Marazzi
Alessandra
A