title: Further experience with OK-432 for lymphangiomas.
abstract: This study includes all the children treated with OK-432 for lymphangioma at our institute. Twenty-nine children treated between 1999 and 2003 are reported for the first time: twelve cases regressed completely, eight cases regressed more than 50% and seven remained unchanged; two cases were lost at follow-up. The outcome was related to the size of the cysts, the larger ones having a better prognosis. The adverse reactions are discussed and the methods of treatment are described in detail. Fifteen children, treated before 1999 and already reported, are reviewed after a long-term follow-up. Four had a recurrence: one regressed spontaneously and three needed further treatment. The other 11 had no complaints. Even considering the risk of recurrence, OK-432 therapy remains our first line therapy for lymphangiomas, avoiding surgery in most cases.
authors.affiliation: Division of Pediatric Surgery, University of Padua, Via Giustiniani 3, 35128 Padua, Italy. clalupap@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Luzzatto
authors.forename: R
authors.initials: R
authors.lastname: Lo Piccolo
authors.forename: F
authors.initials: F
authors.lastname: Fascetti Leon
authors.forename: G F
authors.initials: GF
authors.lastname: Zanon
authors.forename: T
authors.initials: T
authors.lastname: Toffolutti
authors.forename: A
authors.initials: A
authors.lastname: Tregnaghi
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018191:Lymphangioma, Cystic / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D010844:Picibanil / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction; D012075:Remission, Spontaneous
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil