title: [Study on the expression of HSP70 and HSP90beta in nasopharyngeal carcinoma and the clinical significance].
abstract: OBJECTIVE
  To study the expression of HSP70 and HSP90beta and its clinical significance in human nasopharyngeal carcinoma.
  
  
  METHODS
  Immunohistochemical method SP was used to detect the expression of HSP70 and HSP90beta in 50 cases and its clinical significance were studied.
  
  
  RESULTS
  The positive rate of HSP70 and HSP90beta were 72% and 56% respectively. Analysis of patients, survival demonstrated that the prognosis of NPC with HSP70 (-) and HSP90beta (-) expression were significantly better than the others.
  
  
  CONCLUSIONS
  The overexpression of HSP70 and HSP90beta were probably concerned with the occurrence, development and prognosis of nasopharyngeal carcinoma.
authors.affiliation: Department of Otorhinolaryngology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Chuanyu
authors.initials: C
authors.lastname: Liang
authors.forename: Ling
authors.initials: L
authors.lastname: Tian
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
authors.forename: Jumei
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D055815:Young Adult
chemical_list: D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C493165:HSP90AB1 protein, human