title: A review of tribromoethanol anesthesia for production of genetically engineered mice and rats.
abstract: Tribromoethanol (TBE) is easy and inexpensive to make in the laboratory from readily available reagents, requires no special equipment for its administration, and is not subject to federal or state drug enforcement agency regulations. Intraperitoneal (i.p.) injection of TBE results in the simple and rapid induction of short-term surgical anesthesia; however, recent adverse reports about the efficacy and safety of TBE make its continued routine use as a rodent anesthetic controversial. The authors review the history and use of TBE as an animal anesthetic and conclude that TBE should be relegated to acute terminal studies when administered i.p.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, PO Box 6100, Mississippi State, MS 39762-6100, USA. meyer@cvm.msstate.edu
authors.forename: Robert E
authors.initials: RE
authors.lastname: Meyer
authors.forename: Richard E
authors.initials: RE
authors.lastname: Fish
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D000777:Anesthetics / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D030801:Animals, Genetically Modified; D000830:Animals, Laboratory; D004356:Drug Storage / Q000379:methods; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D051379:Mice / Q000235:genetics; D051381:Rats / Q000235:genetics
chemical_list: D000777:Anesthetics; C062527:tribromoethanol; D000431:Ethanol