title: F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp.
abstract: Two new antifungal antibiotics, F2928-1 (1) and -2 (2), were isolated from the culture broth of Cladobotryum sp. These compounds were purified by solvent extraction, silica gel column chromatography and preparative HPLC, consecutively. The structures of these compounds were assigned as a decalin compound on the basis of various spectral analyses. These compounds showed antimicrobial activity against fungi including clinically important fungus, Aspergillus fumigatus.
authors.affiliation: Research Laboratory Agrochemical & Animal Health Products Department, Kaken Pharmaceutical Co., Ltd., 301 Gensuke, Fujieda, Shizuoka 426-8646, Japan. carl-k@syd.odn.ne.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kanai
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tatsumi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tokiwa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishiyama
authors.forename: Toru
authors.initials: T
authors.lastname: Okuda
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004852:Epoxy Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D006999:Hypocreales / Q000737:chemistry* / Q000378:metabolism; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004852:Epoxy Compounds; C506316:F2928-1; C506315:F2928-2; D009281:Naphthalenes