Prevalence of cholelithiasis in patients with chronic inflammatory bowel disease.
OBJECTIVE
To investigate the effect of chronic inflammatory bowel disease (CIBD) specific risk factors for cholecystolithiasis, as duration and involvement pattern of the disease and prior surgery in patients with Crohn's disease (CD) and ulcerative colitis (UC).


METHODS
A total of 222 patients with CD (135 females, 87 males; average age, 35.8+/-11.8 years; range 17-81 years) and 88 patients with UC (39 females, 49 males; average age, 37.2+/-13.6 years; range 16-81 years) underwent clinical and ultrasound examinations. Besides age, sex and degree of obesity, patients' CIBD specific parameters, including duration and extent of disease and prior operations were documented and evaluated statistically using logistic regression.


RESULTS
The overall prevalence of gallbladder stone disease in patients with CD was 13% (n = 30). Only age could be shown to be an independent risk factor (P = 0.014). Compared to a collective representative for the general population in the same geographic region, the prevalence of cholecystolithiasis was higher in all corresponding age groups. Patients with UC showed an overall prevalence of gallbladder stone disease of only 4.6%.


CONCLUSIONS
Disease-specific factors such as duration and extent of disease, and prior surgery are independent risk factors for the development of cholecystolithiasis in patients with CIBD.
Kratzer
Wolfgang
W
University Hospital Ulm, Department of Internal Medicine I, Robert-Koch-Str. 8, 89081 Ulm, Germany. wolfgang.kratzer@medizin.uni-ulm.de
Haenle
Mark-M
MM
Mason
Richard-A
RA
von Tirpitz
Christian
C
Kaechele
Volker
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002769:Cholelithiasis / Q000453:epidemiology*; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D003424:Crohn Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors