title: Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors.
abstract: NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, Camerino, Italy. palmarisa.franchetti@unicam.it
authors.forename: Palmarisa
authors.initials: P
authors.lastname: Franchetti
authors.forename: R
authors.initials: R
authors.lastname: Petrelli
authors.forename: L
authors.initials: L
authors.lastname: Cappellacci
authors.forename: M
authors.initials: M
authors.lastname: Pasqualini
authors.forename: P
authors.initials: P
authors.lastname: Vita
authors.forename: L
authors.initials: L
authors.lastname: Sorci
authors.forename: F
authors.initials: F
authors.lastname: Mazzola
authors.forename: N
authors.initials: N
authors.lastname: Raffaelli
authors.forename: Giulio
authors.initials: G
authors.lastname: Magni
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D009243:NAD / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D008024:Ligands; D009243:NAD; D009612:Nicotinamide-Nucleotide Adenylyltransferase