title: Treating chronic anal fissure with botulinum neurotoxin.
abstract: Recent reports confirm that the management of chronic anal fissure has undergone extensive re-evaluation during the past few years. This rejuvenation of interest is attributable to the application of neurochemical treatment, which has contributed to the tendency to treat the disease on an outpatient basis. The use of botulinum neurotoxin seems to be a promising and safe approach for the treatment of chronic anal fissure, particularly in patients at high risk for incontinence. Indeed, botulinum neurotoxin has been successfully used selectively to weaken the internal anal sphincter as a treatment for chronic anal fissure. It is also more efficacious than nitrate therapy, and is not related to the patient's willingness to complete treatment.
authors.affiliation: Department of Surgery, Catholic School of Medicine, University Hospital Agostino Gemelli, Rome, Italy. g.brisin@tin.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Brisinda
authors.forename: Federica
authors.initials: F
authors.lastname: Cadeddu
authors.forename: Francesco
authors.initials: F
authors.lastname: Brandara
authors.forename: Donatella
authors.initials: D
authors.lastname: Brisinda
authors.forename: Giorgio
authors.initials: G
authors.lastname: Maria
mesh_terms: D001905:Botulinum Toxins / Q000008:administration & dosage*; D002908:Chronic Disease; D005401:Fissure in Ano / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009465:Neuromuscular Agents / Q000008:administration & dosage*
chemical_list: D009465:Neuromuscular Agents; D001905:Botulinum Toxins