An E-MAP of the ER.
Genome-wide phenotype mapping has the potential to provide insights into gene function on an unprecedented scale. In this issue of Cell, Schuldiner et al.(2005) show that saturation epistasis analysis of genes implicated in the early secretory pathway in yeast provides a new strategy for uncovering functional relationships using high-throughput genomic data.
Conibear
Elizabeth
E
Center for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver V5Z 4H4, Canada.
D019295:Computational Biology; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000378:metabolism*; D004843:Epistasis, Genetic; D009154:Mutation; D010641:Phenotype; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D029701:Saccharomyces cerevisiae Proteins