[Cancer genetic predisposition: current events and perspectives 2005].
Studies performed during these last twenty years have had a major impact on the understanding of carcinogenesis. They have opened a new field : cancer genetic predisposition. At the present time, most of the cancer predispositions linked to the alteration of one gene, associated with a high risk of cancer and with a specific phenotype have been identified. About 40 genes have been identified and have led to genetic testing. The indication of genetic testing, the management of at risk patients need the establishment of guidelines. The next challenge is the identification of cancer predisposing genes associated with low risk or modifying the effect of treatment.
Stoppa-Lyonnet
Dominique
D
Service de Génétique, Institut Curie, Paris, France. dominique.stoppa-lyonnet@curie.fr
Lenoir
Gilbert
G
D005260:Female; D005544:Forecasting; D005799:Genes, Dominant; D005808:Genes, Recessive; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D009154:Mutation; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D010641:Phenotype; D012306:Risk