On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease.
The human oxidised low-density lipoprotein receptor 1 (OLR1) gene is a functional candidate for atherosclerosis. An association of the OLR1 gene with acute myocardial infarction (AMI) or coronary artery disease (CAD) has recently been reported. In the present study a total of 677 Italian subjects, 327 CAD-free, 350 CAD, of which 190 with AMI and 160 AMI-free, was genotyped for the following four OLR1 single nucleotide polymorphisms: exon 4 K167N, IVS4 -73C>T, IVS4 -14A>G, and 3'UTR 188 C>T. No statistically significant difference was observed in allele or genotype distribution of the exon 4, intron 4, or 3'UTR SNPs in CAD patients compared to CAD-free subjects, or within CAD, in AMI patients compared to AMI-free patients. A correlation was found between the K167N G/G genotype and the increased number of obstructed vessels. Even if the OLR1 genotype frequency distribution data in CAD or AMI subjects here reported do not fully confirm the positive results of some other association studies, an association with a marker of CAD severity was observed.
Trabetti
Elisabetta
E
Department of Mother and Child and of Biology-Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy. elisabetta.trabetti@univr.it
Biscuola
Michele
M
Cavallari
Ugo
U
Malerba
Giovanni
G
Girelli
Domenico
D
Olivieri
Oliviero
O
Martinelli
Nicola
N
Corrocher
Roberto
R
Pignatti
Pier Franco
PF
D020413:3' Untranslated Regions; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy; D009203:Myocardial Infarction / Q000235:genetics*; D010084:Oxidation-Reduction; D020641:Polymorphism, Single Nucleotide; D051127:Scavenger Receptors, Class E / Q000235:genetics*
D020413:3' Untranslated Regions; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E