Therapy insight: cardiovascular complications associated with muscular dystrophies.
The muscular dystrophies are commonly associated with cardiovascular complications, including cardiomyopathy and cardiac arrhythmias. These complications are caused by intrinsic defects in cardiomyocyte and cardiac conduction system function, and by the presence of severe skeletal muscle disease, which also contributes to cardiac dysfunction. Unlike the skeletal muscle degenerative process, for which treatment options are currently limited, therapy is available for the cardiovascular complications that accompany muscular dystrophy. New therapies for skeletal muscle degeneration are moving into clinical trials and, ultimately, into clinical practice. These therapies are expected to also improve the cardiac function, longevity and wellbeing of muscular dystrophy patients.
McNally
Elizabeth M
EM
Department of Medicine, University of Chicago, IL 60637, USA. emcnally@medicine.bsd.uchicago.edu
MacLeod
Heather
H
D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology*; D016189:Dystrophin / Q000235:genetics; D006801:Humans; D009136:Muscular Dystrophies / Q000150:complications* / Q000235:genetics; D009154:Mutation; D018570:Risk Assessment; D012307:Risk Factors; D049031:Sarcoglycans / Q000235:genetics
C484258:DMD protein, human; D016189:Dystrophin; C483098:SGCB protein, human; D049031:Sarcoglycans