title: Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.
abstract: To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 degrees C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.
authors.affiliation: Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City University, Japan.
authors.forename: Michihiko
authors.initials: M
authors.lastname: Fujii
authors.forename: Nanae
authors.initials: N
authors.lastname: Tanaka
authors.forename: Kensuke
authors.initials: K
authors.lastname: Miki
authors.forename: Mohammad Nazir
authors.initials: MN
authors.lastname: Hossain
authors.forename: Morio
authors.initials: M
authors.lastname: Endoh
authors.forename: Dai
authors.initials: D
authors.lastname: Ayusawa
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D004351:Drug Resistance / Q000235:genetics*; D008136:Longevity; D023421:Models, Animal; D018384:Oxidative Stress; D010269:Paraquat / Q000494:pharmacology*
chemical_list: D010269:Paraquat