Isolated abducens nerve palsy associated with retinoic acid therapy: a case report.
Isolated abducens nerve palsy is a rare complication of treatment with various drugs. Here, the authors report the case of a 23-year-old female with isolated left abducens nerve palsy after long-term retinoic acid therapy. The association is based on the temporal relationship and the exclusion of other possible etiologic factors following extensive laboratory and imaging diagnostics. The authors suggest that isolated abducens nerve palsy may be a presenting sign of a toxic neuropathy associated with retinoic acid therapy. After the exclusion of other organic lesions, especially idiopathic intracranial hypertension, and an assessment of the risk-benefit ratio, discontinuation of treatment must be considered in such cases.
Alemdar
Murat
M
Department of Neurology, Kocaeli University Faculty of Medicine, Izmit, Kocaeli, Turkey. drmuratalemdar@yahoo.com
Iseri
Pervin
P
Selekler
Hamit Macit
HM
Serbest
Alev Selek
AS
Komsuoglu
Sezer Sener
SS
D020434:Abducens Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D000328:Adult; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D014212:Tretinoin