[Effect of neutralizing anti-VEGF antibody on genesis of murine type II collagen-induced arthritis].
OBJECTIVE
To understand the effect of neutralizing anti-vascular endothelial growth factor (VEGF) antibody on the genesis of murine type II collagen (CO II)-induced arthritis (CIA).


METHODS
mice DBA/1J (8-10 weeks) were given intradermal injection chick tape II collagen to set up the murine CIA model. The incidence of CIA and arthritis index were measured and the pathologic changes of articular tissue were observed after the injection of neutralizing anti-VEGF antibody.


RESULTS
The anti-VEGF antibody could notably inhibit the genesis and severity of arthritis (P<0.05) at the early stage of CIA formation; while it made no difference after CIA was completely formed.


CONCLUSIONS
Anti-VEGF neutralizing antibody can significantly inhibit synovial fibroblast proliferation, neovascularization and angeitis genesis, which made it a promising agent for RA treatment.
Lu
Jing
J
Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China. lujingtan@163.com
Shen
Hui
H
Yang
Ping-ting
PT
Xiao
Wei-guo
WG
Zhao
Li-juan
LJ
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D024043:Collagen Type II / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D013583:Synovial Membrane / Q000166:cytology; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*
D000906:Antibodies; D024043:Collagen Type II; D042461:Vascular Endothelial Growth Factor A