[The calcium receptor and magnesium metabolism].
The calcium receptor (CaR), which regulates Ca(2+) homeostasis, senses Mg(2+) and participates in Mg(2+) metabolism mainly at the parathyroid gland and kidney as well as Ca(2+) metabolism. In the parathyroid gland, Mg(2+) suppresses parathyroid hormone (PTH) secretion by the activation of CaR, and regulates the sensitivity of CaR by its unique effect. In the kidney, the activation of CaR inhibits Mg(2+) reabsorption directly or indirectly, mainly at the downstream of loop of Henle.
Kawata
Takehisa
T
Pharmaceutical Development Laboratories, Phamaceutical Division, Kirin Brewery Company, Limited.
Nagano
Nobuo
N
D000818:Animals; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008274:Magnesium / Q000378:metabolism*; D010280:Parathyroid Glands / Q000502:physiology; D044169:Receptors, Calcium-Sensing / Q000502:physiology*
D044169:Receptors, Calcium-Sensing; D008274:Magnesium