title: Body-size regulation: combining genetics and physiology.
abstract: New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth.
authors.affiliation: Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA. ashingle@princeton.edu
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Shingleton
mesh_terms: D000818:Animals; D049628:Body Size / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins / Q000378:metabolism; D004440:Ecdysone / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007814:Larva / Q000254:growth & development; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; D004440:Ecdysone; D007328:Insulin; D019869:Phosphatidylinositol 3-Kinases; D051059:PTEN Phosphohydrolase; C487101:PTEN protein, Drosophila