title: Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats.
abstract: The aim of this study was to clarify the role of the renal sympathetic nerves in the gamma-aminobutyric acid (GABA)-induced hypotensive effect in spontaneously hypertensive rats. Male spontaneously hypertensive rats (SHR/Izm) aged 7 weeks were divided into four groups on the basis of diet (containing 0.05% GABA, or GABA-free control diet) and operation (renal sympathetic-denervated or sham-operated) (n = 10, each). Water intake, urine volume and urinary sodium were, or tended to be, slightly higher, while plasma renin activity was significantly lower in the GABA group than the GABA-free control group. GABA inhibited the development of hypertension in sham-operated spontaneously hypertensive rats but not in renal-denervated spontaneously hypertensive rats. Plasma renin activity was significantly higher in sham-operated spontaneously hypertensive rats fed the control diet than in the other three groups. These results suggest that a reduction in the effects induced by the renal nerves may play an important role in the hypotensive effect induced in spontaneously hypertensive rats by chronic dietary administration of GABA.
authors.affiliation: Yakult Central Institute for Microbiological Research, Kunitachi-shi, Tokyo, Japan. kazuhito-hayakawa@yakult.co.jp
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hayakawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kimura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamori
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D003714:Denervation; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D007668:Kidney / Q000294:innervation*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors; D014556:Urine; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D003404:Creatinine; D012083:Renin