title: A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.
abstract: Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
authors.affiliation: Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. Robert.J.Chambers@pfizer.com
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Chambers
authors.forename: Kristin
authors.initials: K
authors.lastname: Abrams
authors.forename: Tessa A
authors.initials: TA
authors.lastname: Castleberry
authors.forename: John B
authors.initials: JB
authors.lastname: Cheng
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Fisher
authors.forename: Ajith V
authors.initials: AV
authors.lastname: Kamath
authors.forename: Anthony
authors.initials: A
authors.lastname: Marfat
authors.forename: David O
authors.initials: DO
authors.lastname: Nettleton
authors.forename: Joann D
authors.initials: JD
authors.lastname: Pillar
authors.forename: Eben D
authors.initials: ED
authors.lastname: Salter
authors.forename: Alissa L
authors.initials: AL
authors.lastname: Sheils
authors.forename: John T
authors.initials: JT
authors.lastname: Shirley
authors.forename: Claudia R
authors.initials: CR
authors.lastname: Turner
authors.forename: John P
authors.initials: JP
authors.lastname: Umland
authors.forename: Kelvin T
authors.initials: KT
authors.lastname: Lam
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000502:physiology*; D002633:Chemotaxis / Q000187:drug effects; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004804:Eosinophils / Q000187:drug effects / Q000502:physiology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D009536:Niacinamide / Q000037:antagonists & inhibitors*; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020889:Rolipram / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors; D009536:Niacinamide; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram