title: Effects of vagal pacing on food intake and body mass in pigs.
abstract: In obesity patients inexpensive, non-invasive, low risk treatment remains a holy grail. The purpose of this study was to evaluate effect of long term and low frequency vagal pacing on feeding behavior in pigs.
  
  
  METHODS
  Two groups of animals were investigated, first control with sham operation and second group with microchip (MC) on both vagal nerves placed laparoscopically. In both groups EGG was performed before and after MC implantation. Parameters of stimulation were stable (amplitude 170 mV, frequency 1 Hz, impulse duration 170 ms).
  
  
  RESULTS
  MC group demonstrated continuous decrease in body weight gain during 8 weeks of experiment at average of 3.73 +/- 0.5 vs. 4.83 +/- 1.1 (p < 0.05). Food intake also decreased in MC group and was 16.38 +/- 1.3 vs. control 17.5 +/- 1.7 kg/w (ns). EGG recording showed decreased percent normogastria in MC group 26.66 +/- 10 vs. 76.2 +/- 16 (p < 0.05) mostly at cost of tachygastria 62.3 +/- 15 vs. 35.4 +/- 16% of the recording time.
  
  
  CONCLUSIONS
  MC vagal pacing mostly decreased body weight being without significant influence on food intake causing gastric dysrhythmia.
authors.affiliation: I Katedra Chriurgii, Collegium Medicum Uniwersytetu Jagiellońskiego.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Matyja
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Thor
authors.forename: Jacek
authors.initials: J
authors.lastname: Sobocki
authors.forename: Janusz
authors.initials: J
authors.lastname: Laskiewicz
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kekus
authors.forename: Ryszard
authors.initials: R
authors.lastname: Tuz
authors.forename: Józef
authors.initials: J
authors.lastname: Koczanowski
authors.forename: Wiesław
authors.initials: W
authors.lastname: Zaraska
mesh_terms: D000818:Animals; D015992:Body Mass Index; D001835:Body Weight; D004435:Eating; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy / Q000295:instrumentation; D005260:Female; D009765:Obesity / Q000503:physiopathology* / Q000628:therapy; D013552:Swine; D014630:Vagus Nerve / Q000503:physiopathology*