title: The fundamental theorem of neutral evolution: rates of substitution and mutation should factor in premeiotic clusters.
abstract: Mutations do not always arise as single events. Many new mutations actually occur in the cell lineage before germ cell formation or meiosis and are therefore replicated pre-meiotically. The increased likelihood of substitutions caused by these clusters of new mutant alleles can change the fundamental theorem of neutral evolution.
authors.affiliation: Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA. rwoodru@bgnet.bgsu.edu
authors.forename: R C
authors.initials: RC
authors.lastname: Woodruff
authors.forename: J N
authors.initials: JN
authors.lastname: Thomson
mesh_terms: D000483:Alleles; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008540:Meiosis / Q000235:genetics; D008957:Models, Genetic; D005810:Multigene Family; D009154:Mutation