Hemogram and myelogram in progressing non-Hodgkin's lymphomas.
Parameters of hemogram and myelogram were studied in patients with aggressive and indolent non-Hodgkin's lymphomas: the relationships between the parameters recorded before treatment and during remission or progress 6 months after chemotherapy were studied by multifactorial analysis. The progress of indolent non-Hodgkin's lymphomas was associated with changes caused by tumor infiltration of the bone marrow; lymphocytosis in the myelogram or hemogram was associated with a relative decrease in the count of granulocytic hemopoietic stem cells. A sign associated with the absence of remission in aggressive non-Hodgkin's lymphomas was decreased level of hemoglobin and erythroid cells. Changes in myelogram attesting to anemia and suppressed erythropoiesis before chemotherapy are additional prognostic factors indicating obligatory intensification of chemotherapy for patients with aggressive non-Hodgkin's lymphomas.
Domnikova
N P
NP
Laboratory of Molecular Cellular and Immunomorphological Bases of Oncohematology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. pathol@soramn.ru
Degtyareva
V V
VV
Mukhin
O V
OV
Nepomnyashchikh
L M
LM
D000704:Analysis of Variance; D001854:Bone Marrow Cells / Q000166:cytology; D018450:Disease Progression; D004358:Drug Therapy; D041905:Erythroid Cells / Q000166:cytology; D005260:Female; D042381:Granulocyte Precursor Cells / Q000166:cytology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D006454:Hemoglobins