The proteasome: not just degrading anymore.
The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions.
Baker
Stephen P
SP
Department of Biochemistry and Molecular Genetics, University of Virginia Schol of Medicine, Charlottesville, Virginia 22908, USA.
Grant
Patrick A
PA
D015966:Gene Expression Regulation, Fungal; D006657:Histones / Q000378:metabolism; D011401:Promoter Regions, Genetic; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation; D014452:Ubiquitins / Q000378:metabolism
D006657:Histones; C114551:NAS6 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex