title: [Diagnosis and treatment of invasive cervical cancer in Cambodia (apropos of 35 cases)].
abstract: Uterine cervix cancer is an important public health problem in developing countries. In Cambodia, incidence (24. 10-5) and mortality (12,77. 10-5) rates due to this cancer are higher than in other southeast Asian countries. 35 consecutive women with a diagnosis of invasive cervical cancer were identified from the histology laboratory of the Institut Pasteur in Phnom Penh. Information on history, clinical findings, ancillary investigations and treatment were obtained by clinical files review. Patients were from Phnom Penh, the main city and from outlying provinces. The mean age was 50 years, 2 months. They all presented with clinical symptoms at the time of diagnosis, and lesions had spread beyond the uterus in nearly half of the cases. Squamous cell carcinoma (80%) was more frequent than adenocarcinoma (14%). Microinvasive squamous cell carcinomas were rare (2.8%). Treatment was mainly surgical, but lacked standardization, as radical hysterectomy including lymphadenectomy was not systematic, even when the tumor spread beyond the uterine cervix. Few women that required adjuvant radiotherapy received it as this technique has only recently been introduced in Cambodia. Many patients were lost to follow-up. None of the cases was detected by pap smear. This technique is not in general use in the country. Cervical cancer screening could be carried out by visual inspection of the cervix with acetic acid wash that is less expensive and nearly as sensitive as pap smear. Treatments are still insufficiently standardized, due to the lack of technical means, and lack of patient compliance.
authors.affiliation: Institut Pasteur du Cambodge, Pnom Penh, Cambodge. dmonchy@pasteur-kh.org
authors.forename: D
authors.initials: D
authors.lastname: Monchy
authors.forename: C R
authors.initials: CR
authors.lastname: Lieng
authors.forename: L S
authors.initials: LS
authors.lastname: Kruy
authors.forename: K
authors.initials: K
authors.lastname: Kahler
authors.forename: S
authors.initials: S
authors.lastname: Eav
mesh_terms: D019342:Acetic Acid; D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000465:Algorithms; D002160:Cambodia / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D004396:Coloring Agents; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015994:Incidence; D008197:Lymph Node Excision; D008403:Mass Screening; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery
chemical_list: D004396:Coloring Agents; D019342:Acetic Acid