[Management of children with hypercholesterolemia].
The management of children with hypercholesterolemia (HC) depends on the level of premature atherosclerosis - associated risk. Inherited autosomal-dominant forms of HC (Family HC, Familial deficiency of apolipoprotein B, Family combined dyslipidemia) are at high risk of premature cardiovascular disease. These inherited forms of HC need to be systematically screened during childhood in case of family history and require a long term follow-up in order to prevent adult coronary insufficiency. The first recommended therapy consists in dietary intervention. When necessary, treatment with statin can be used from 8 years old. Before this age, acid-binding resins remain the first step treatment. Plant sterol-esters enriched spreads could be an additional useful treatment.
Girardet
J-P
JP
Service de gastroentérologie et de nutrition pédiatriques, hôpital Armand-Trousseau, 26, avenue du Docteur-Arnold-Netter, 75571 Paris, cedex 12 France. jean-philippe.girardet@trs.aphp.fr
D017668:Age of Onset; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy* / Q000188:drug therapy* / Q000235:genetics; D012307:Risk Factors
D000924:Anticholesteremic Agents