title: Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura.
abstract: Two new dihydrochalcones, 2',4'-dihydroxy-3'-methoxydihydrochalcone, (-)-3'-methoxy-2',4',beta-trihydroxydihydrochalcone, a new flavanone, (2 S)-(-)-5'-hydroxy-7,3',4'-trimethoxyflavanone, and a new flavonol derivative, muntingone, along with sixteen known compounds, were isolated from the leaves of Muntingia calabura. The structures of these new compounds were determined using spectral analyses including extensive 2D NMR data. Among the isolates, (2 S)-5'-hydroxy-7,3',4'-trimethoxyflavanone, 4'-hydroxy-7-methoxyflavanone, 2',4'-dihydroxychalcone, and 2',4'-dihydroxy-3'-methoxychalcone exhibited cytotoxicity (IC (50) values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Technology, Tajen Institute of Technology, Pingtung, Taiwan 907, R.O.C. jjchen@ccsun.tajen.edu.tw
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Hsinn-Hsing
authors.initials: HH
authors.lastname: Lee
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D047188:Chalcones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D029646:Tiliaceae
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D005419:Flavonoids; D010936:Plant Extracts