Reduced pulsatility does not explain renal hyporesponsiveness to cardiac natriuretic peptides in pulmonary hypertension.
A pulsatile secretory pattern is assumed to improve hormonal efficiency. We examined the short-term time courses of circulating atrial (ANP) and brain natriuretic peptides (BNP) in patients with pulmonary hypertension (PH) and reduced renal efficiency of ANP-BNP, reflected by low natriuresis/ANP or BNP ratios. Compared to controls, we observed a persistence of ANP and BNP pulsatility in PH patients with a similar periodicity of 20min. Pulse amplitude increased proportionally to the rise in mean plasma level observed in patients (around 27%). In PH patients, the decrease in ANP-BNP renal efficiency is not attributable to a loss of the rhythmic pulsatility of these hormones.
Charloux
Anne
A
Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Institut de Physiologie, 4 rue Kirschleger, 67085 Strasbourg Cedex, France. Anne.Charloux@chru-strasbourg.fr
Chaouat
Ari
A
Brandenberger
Gabrielle
G
Piquard
François
F
Weitzenblum
Emmanuel
E
Geny
Bernard
B
D006328:Cardiac Catheterization; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D045265:Natriuretic Peptides / Q000494:pharmacology*; D010507:Periodicity; D013997:Time Factors
D045265:Natriuretic Peptides; D020097:Natriuretic Peptide, Brain