title: Severe preeclampsia is associated with a positive family history of hypertension and hypercholesterolemia.
abstract: OBJECTIVE
  To investigate an association between a family history of cardiovascular disease and severe preeclampsia and/or HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low Platelets).
  
  
  METHODS
  One hundred twenty-eight women with a history of severe preeclampsia and/or HELLP syndrome and 123 women with previous uncomplicated pregnancies only were included in the study. All participants completed questionnaires about diagnoses of cardiovascular diseases, hypertension, and hypercholesterolemia among their first-degree relatives, which were subsequently confirmed by the relatives' general practitioners. The main outcome measures were the prevalence of cardiovascular diseases, hypertension, and hypercholesterolemia among first-degree relatives of both groups. Statistical analysis was done using chi(2)-analysis.
  
  
  RESULTS
  The prevalence of familial cardiovascular disease among women with a history of severe preeclampsia and/or HELLP syndrome (23%) compared to controls (19%) was not significantly different (OR 1.3, 95%CI 0.7-2.5). However, women with a history of severe preeclampsia and/or HELLP syndrome more often had one or more first-degree relatives with hypertension and/or hypercholesterolemia before the age of 60 years compared to controls (54% vs. 32%, respectively; OR 2.6, 95%CI 1.5-4.3). The prevalence of hypertension and hypercholesterolemia among first-degree relatives, irrespective of age, also was significantly higher among women with a history of severe preeclampsia and/or HELLP syndrome as compared to controls (60% vs. 42%, respectively; OR 2.0, 95%CI 1.2-3.4).
  
  
  CONCLUSIONS
  Severe preeclampsia is associated with a positive family history of hypertension and/or hypercholesterolemia.
authors.affiliation: Department of Obstetrics and Gynaecology, University Medical Center, Nijmegen, The Netherlands.
authors.forename: E M
authors.initials: EM
authors.lastname: Roes
authors.forename: R
authors.initials: R
authors.lastname: Sieben
authors.forename: M T M
authors.initials: MT
authors.lastname: Raijmakers
authors.forename: W H M
authors.initials: WH
authors.lastname: Peters
authors.forename: E A P
authors.initials: EA
authors.lastname: Steegers
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D017359:HELLP Syndrome / Q000235:genetics*; D006801:Humans; D006937:Hypercholesterolemia / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D012307:Risk Factors; D011795:Surveys and Questionnaires