Reparative osteogenesis during transplantation of mesenchymal stem cells.
Reparative osteogenesis was studied after xenotransplantation of suspension cell graft from human mesenchymal stem cells. A model of experimental damage to rat femoral diaphysis was developed. The state of animals was satisfactory and non-depressed in the early and late postoperation period. We revealed no local pathological reactions and complications. Administration of mesenchymal stem cells into the area of bone defect accelerated and improved regeneration. Unilateral transplantation of the cell graft stimulated regeneration in the contralateral limb due to acceleration of bone tissue maturation. On day 90 after treatment the bone regenerate was completely developed in the area of defect in animals of various groups. The newly formed bone tissue was well integrated into the bone organ.
Fatkhudinov
T Kh
TKh
Institute of Stem Cell and Cell Technologies, Russian Academy of Medical Sciences, Moscow. fatkhudinov@iscct.ru
Goldshtein
D V
DV
Pulin
A A
AA
Shamenkov
D A
DA
Rzhaninova
A A
AA
Gornostaeva
S A
SA
Grigor'yan
A S
AS
Kulakov
A A
AA
D000818:Animals; D018483:Diaphyses / Q000293:injuries; D005269:Femur / Q000293:injuries*; D006652:Histological Techniques; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D012038:Regeneration / Q000502:physiology*; D014183:Transplantation, Heterologous; D014945:Wound Healing / Q000502:physiology*