Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers.
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
Ennis
Sarah
S
Genetic Epidemiology & Bioinformatics Group, Human Genetics Division, University of Southampton, Southampton, UK.
Ward
Daniel
D
Murray
Anna
A
D000367:Age Factors; D015139:Blotting, Southern; D004587:Electrophoresis, Agar Gel; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007407:Interviews as Topic; D008593:Menopause / Q000235:genetics*; D008875:Middle Aged; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D012044:Regression Analysis; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human