Oral malignancies in HIV disease: changes in disease presentation, increasing understanding of molecular pathogenesis, and current management.
Infection with human immunodeficiency virus (HIV) and progression to acquired immune deficiency syndrome (AIDS) are associated with a vide variety of morbidities. Local and systemic diseases can develop in association with HIV infection and may manifest themselves as malignancies of the oropharynx. Advances in HIV management, fueled by increasing understanding of molecular pathogenesis, have resulted in marked changes in the prevalence of oral malignant disease. This paper discusses recent trends in the presentation and treatment of malignancies related to HIV and AIDS with an emphasis on malignancies seen in the oral cavity.
Epstein
Joel B
JB
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, Chicago Cancer Center, University of Illinois at Chicago, IL 60612USA. jepstein@uic.edu
Cabay
Robert J
RJ
Glick
Michael
M
D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000453:epidemiology / Q000628:therapy / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D019049:Developed Countries; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D009062:Mouth Neoplasms / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D012514:Sarcoma, Kaposi / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D014481:United States / Q000453:epidemiology
D004279:DNA, Viral