Molecular links between centrosome and midbody.
The terminal step in cytokinesis that severs a cell in two-abscission-is poorly understood. In Developmental Cell, Fabbro et al (2005) identify a centrosome protein whose multiple phosphorylations regulate its movement from centrosome to midbody and completion of abscission.
Doxsey
Stephen J
SJ
Program in Molecular Medicine, University of Massachusetts Medical School, Biotech 2, 373 Plantation Street, Worcester, Massachusetts 01605, USA.
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism*; D048749:Cytokinesis / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*
C474898:CNTRL protein, human; D018797:Cell Cycle Proteins; C505378:Cep55 protein, human; D003598:Cytoskeletal Proteins; D009687:Nuclear Proteins