title: Clinical experience with the use of cyclosporin A in psoriasis. Results of a retrospective study.
abstract: The efficacy of cyclosporin A (Sandimmun Neoral) in severe psoriasis was analysed in 70 patients included in a retrospective descriptive study conducted at our Dermatology Department from January 1994 until December 2000. After 8 weeks of treatment, with an initial dose of 2.5-3 mg/kg/day, the reduction in the Psoriasis Area and Severity Index (PASI) score was>75% in 61% of patients. Most of the side effects observed turned out to be susceptible to being reversed over time or by dose reduction. The results of this study show that continuous and low-dose cyclosporin therapy is a safe and efficacious treatment for severe chronic psoriasis.
authors.affiliation: Psoriasis Unit, Department of Dermatology, Hospital Sagrat Cor, Barcelona, Spain. ireuaumu@retemail.es
authors.forename: R
authors.initials: R
authors.lastname: Ojeda
authors.forename: M
authors.initials: M
authors.lastname: Sánchez Regaña
authors.forename: J
authors.initials: J
authors.lastname: Massana
authors.forename: R
authors.initials: R
authors.lastname: Oliete
authors.forename: P
authors.initials: P
authors.lastname: Umbert
mesh_terms: D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine