title: The significance of elevated CSF lactate.
abstract: The final diagnosis of 158 patients who had a cerebrospinal fluid (CSF) lactate concentration greater than 2 mmol/l was ascertained. The conditions included seizures, inflammatory changes, and proven metabolic disorders. For the diagnosis of congenital lactic acidoses, CSF lactate should ideally be measured in a seizure free patient after any acute illness.
authors.affiliation: Metabolic Unit, Great Ormond Street Hospital for Children, London, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Chow
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Rooney
authors.forename: M A
authors.initials: MA
authors.lastname: Cleary
authors.forename: P T
authors.initials: PT
authors.lastname: Clayton
authors.forename: J V
authors.initials: JV
authors.lastname: Leonard
mesh_terms: D000140:Acidosis, Lactic / Q000134:cerebrospinal fluid / Q000151:congenital / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid / Q000175:diagnosis; D019344:Lactic Acid / Q000134:cerebrospinal fluid*; D008661:Metabolism, Inborn Errors / Q000134:cerebrospinal fluid / Q000175:diagnosis; D009369:Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis; D012640:Seizures / Q000134:cerebrospinal fluid
chemical_list: D015415:Biomarkers; D019344:Lactic Acid