title: Fluoroquinolone-resistant Vibrio cholerae isolated during a cholera outbreak in India.
abstract: During the cholera epidemic of 2002 in and around Hubli, south India, Vibrio cholerae strains resistant to fluoroquinolones were isolated. Among the isolates of V. cholerae non-O1, non-O139 serogroups, 55.9% and 47.1% were resistant to norfloxacin and ciprofloxacin, respectively. However, only 12.5% of the O1 serogroup strains were resistant to both norfloxacin and ciprofloxacin. Though the O139 serogroup strains were susceptible to these antibiotics, they exhibited multidrug resistance. Emergence of fluoroquinolone-resistant V. cholerae that also exhibited multidrug resistance is of great significance in the epidemiology and control of cholera.
authors.affiliation: Department of Microbiology, Karnataka Institute of Medical Sciences, Hubli 580022, India. bvsk@yahoo.com
authors.forename: B V S
authors.initials: BV
authors.lastname: Krishna
authors.forename: Asha B
authors.initials: AB
authors.lastname: Patil
authors.forename: M R
authors.initials: MR
authors.lastname: Chandrasekhar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology; D002939:Ciprofloxacin / Q000627:therapeutic use; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use; D014734:Vibrio cholerae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D009643:Norfloxacin