title: Nonlinear photodynamic therapy: method of pulsed oxygen depletion.
abstract: The photodynamic therapy technique involving pulsed oxygen depletion (POD) in tissue by long high-energy pulses of light was studied theoretically. The possibility of creating a uniform distribution of a therapeutic dose throughout a tumor using both surface and interstitial irradiation is shown. Possible thickness of the treated tissue layer is estimated. The comparison with other methods of nonlinear photodynamic therapy is made.
authors.affiliation: Organic Intermediates and Dyes Institute, B. Sadovaya str. 1/4, 123995 Moscow, Russia. bkogan@mail.mipt.ru
authors.forename: Boris Ya
authors.initials: BY
authors.lastname: Kogan
mesh_terms: D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D008027:Light; D008962:Models, Theoretical; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism*; D010101:Oxygen Consumption / Q000528:radiation effects; D010777:Photochemistry; D010778:Photochemotherapy / Q000379:methods*
chemical_list: D010100:Oxygen