[Experimental (in vivo) study of the capacities of use of radachlorine (chlorine E-6) for photodynamic therapy in ophthalmology].
To study the capacities of ophthalmological application of the photosensitizer Radachlorine (0.35% solution for intravenous injection), the authors carried out a series of in vivo experiments on rabbits. They studied the time parameters of distribution of the agent in the chorioretinal complex and the reaction of newly formed vessels to photodynamic therapy. Radiation of a diode laser at a wavelength of 0.662 microm was used to stimulate the photosensitizer. A video micro-camera adapted to the ocular of a split lamp was applied to fluorescence fixation. Superficial corneal vascularization was used as a model of the neovascular membrane in response to the application of a non-penetrating silk suture. The findings suggest that photodynamic therapy using Radachlorine is safe and effective in treating ocular tissue neovascularization.
Siplivyĭ
V I
VI
Bolshunov
A V
AV
Reshetnikov
A V
AV
Goncharov
S E
SE
Armichev
A V
AV
Velieva
I A
IA
Sosnovskiĭ
V V
VV
D000818:Animals; D002735:Chlorophyllides; D020256:Choroidal Neovascularization / Q000188:drug therapy; D016510:Corneal Neovascularization / Q000188:drug therapy; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000188:drug therapy*; D005453:Fluorescence; D007275:Injections, Intravenous; D007834:Lasers; D010778:Photochemotherapy; D011166:Porphyrins / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015861:Retinal Neovascularization / Q000188:drug therapy
D002735:Chlorophyllides; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C062985:phytochlorin