New quinolone resistance phenomenon in Salmonella enterica: nalidixic acid-susceptible isolates with reduced fluoroquinolone susceptibility.
We describe the emergence of a new quinolone resistance pattern in Salmonella enterica isolates from Southeast Asia. These isolates are susceptible to nalidixic acid but exhibit reduced susceptibility to ciprofloxacin. The increase of such strains may threaten the value of the nalidixic acid disk test to screen for reduced fluoroquinolone susceptibility in salmonellas.
Hakanen
Antti J
AJ
Antimicrobial Research Laboratory, National Public Health Institute, P.O. Box 57, 20521 Turku, Finland. antti.hakanen@utu.fi
Lindgren
Marianne
M
Huovinen
Pentti
P
Jalava
Jari
J
Siitonen
Anja
A
Kotilainen
Pirkko
P
D000890:Anti-Infective Agents / Q000494:pharmacology; D001208:Asia; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009268:Nalidixic Acid / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*; D012480:Salmonella Infections / Q000382:microbiology; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics; D014195:Travel
D000890:Anti-Infective Agents; D015363:Quinolones; D009268:Nalidixic Acid; D002939:Ciprofloxacin