title: Blood coagulation initiates respiratory burst in neutrophils.
abstract: Using the in vitro reaction of nitroblue tetrazolium reduction we showed that blood coagulation stimulates production of reactive oxygen species by human neutrophils. Heparin and chondroitin sulfate produced by thrombin-activated basophils are good candidates for inductors of these processes. Similar activation probably occurs in vivo under the influence of inductors secreted by mast cells.
authors.affiliation: Institute for Medical Problems of Family, M. Gorky Donetsk State Medical University.
authors.forename: I G
authors.initials: IG
authors.lastname: Gerasimov
authors.forename: D Yu
authors.initials: DY
authors.lastname: Ignatov
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D002809:Chondroitin Sulfates; D005260:Female; D006493:Heparin / Q000378:metabolism; D006801:Humans; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D009580:Nitroblue Tetrazolium; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016897:Respiratory Burst / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D009580:Nitroblue Tetrazolium; D006493:Heparin; D002809:Chondroitin Sulfates