Studying cellular processes and detecting disease with protein microarrays.
Protein microarrays are a rapidly developing analytic tool with diverse applications in biomedical research. These applications include profiling of disease markers or autoimmune responses, understanding molecular pathways, protein modifications, and protein activities. One factor that is driving this expanding usage is the wide variety of experimental formats that protein microarrays can take. In this review, we provide a short, conceptual overview of the different approaches for protein microarray. We then examine some of the most significant applications of these microarrays to date, with an emphasis on how global protein analyses can be used to facilitate biomedical research.
Zangar
Richard C
RC
Pacific Northwest National Laboratory, Richland, Washington 99352, USA. richard.zangar@pnl.gov
Varnum
Susan M
SM
Bollinger
Nikki
N
D002468:Cell Physiological Phenomena; D019937:Diagnostic Techniques and Procedures / Q000639:trends*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis; D040081:Protein Array Analysis / Q000379:methods / Q000639:trends*