The role of the carboxamide group in nicotinamide adenine dinucleotide in relation to hydride transfer: the reduced form of the dinucleotide as remedy in the modulation of neurotransmission.
The stereochemical significance of the carboxamide group in combination with the ring nitrogen in NADH-NAD+ conversions has been demonstrated. This has been shown in model systems as well as under enzymatic conditions. The role of the carboxamide group in selective regiospecific interactions has been discussed for neurodegenerative diseases.
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D000227:Adenine Nucleotides / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D000818:Animals; D002244:Carbon / Q000737:chemistry*; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006801:Humans; D006859:Hydrogen / Q000737:chemistry; D007700:Kinetics; D008968:Molecular Conformation; D009243:NAD / Q000737:chemistry*; D019636:Neurodegenerative Diseases / Q000473:pathology; D009474:Neurons / Q000378:metabolism*; D009584:Nitrogen / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry; D017510:Protein Folding; D013237:Stereoisomerism; D009435:Synaptic Transmission / Q000502:physiology*
D000227:Adenine Nucleotides; D000577:Amides; D015226:Dinucleoside Phosphates; D009711:Nucleotides; D009243:NAD; D002244:Carbon; D006859:Hydrogen; D009584:Nitrogen