title: Synthesis of conformationally restricted nucleic acid fragments using ring-closing alkene and enyne metathesis reactions.
abstract: In the aim of constructing conformationally restricted nucleic acid fragments for the recognition of secondary RNA structures, we have synthesized different mono- and dinucleotides containing extra rings. These rings were prepared by ring-closing alkene or enyne metathesis reactions from nucleotide substrates in which double or triple bonds have been introduced.
authors.affiliation: Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense, Denmark.
authors.forename: Signe I
authors.initials: SI
authors.lastname: Steffansen
authors.forename: Mikkel S
authors.initials: MS
authors.lastname: Christensen
authors.forename: Philip
authors.initials: P
authors.lastname: Børsting
authors.forename: Poul
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry; D009705:Nucleosides / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D013777:Tetrazoles / Q000737:chemistry; D014529:Uridine / Q000737:chemistry
chemical_list: D000475:Alkenes; D000480:Alkynes; D009696:Nucleic Acids; D009705:Nucleosides; D009711:Nucleotides; D013777:Tetrazoles; D012313:RNA; D014529:Uridine