title: [Synthesis and antitumor activity of arylsubstituted imidazolin-2-one derivatives].
abstract: OBJECTIVE
  To design and synthesize new arylsubstituted imidazolin-2-one analogues as antitumor compounds.
  
  
  METHODS
  Arylsubstituted imidazolin-2-ones were prepared by condensation the appropriate omega-amino-acetophenone hydrochloride with arylisocyanate in toluene. The target compounds prepared in this study were tested for cytotoxicity against PC-3, A549, HO-8910, Hela, HL60, K562 and HL60R cancer cell lines, and mechanism of one of the products 4y was further evaluated with its mechanium.
  
  
  RESULTS
  Thirty-six new compounds were synthesized and confirmed by 1H NMR, MS and elemental analysis. One of the synthesized products, compound 4y, displayed an encouraging selective activity against HL60 cells, and it was partlydue to the cell cycle arrest and cell apoptosis.
  
  
  CONCLUSIONS
  Compound 4y is worthy to be intensively studied.
authors.affiliation: School of Pharmaceutical Science, Zhejiang University, Hangzhou 310031, China.
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Cheng
authors.forename: Yong-zhou
authors.initials: YZ
authors.lastname: Hu
authors.forename: Qiao-jun
authors.initials: QJ
authors.lastname: He
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D018922:HL-60 Cells; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D048288:Imidazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: C518117:3,4-diphenyl-imidazol-2-one-1-carboxylic acid phenyl amide; D000577:Amides; D000970:Antineoplastic Agents; D007093:Imidazoles; D048288:Imidazolines