title: Flies and their golden apples: the effect of dietary restriction on Drosophila aging and age-dependent gene expression.
abstract: Reduced nutrient availability (dietary restriction) extends lifespan in species as diverse as yeast, nematode worms, Daphnia, Drosophila, and mammals. Recent demographic experiments have shown that moderate nutrient manipulation in adult Drosophila affects current mortality rate in a completely reversible manner, which suggests that dietary restriction in Drosophila increases lifespan through a reduction of the current risk of death rather than a slowing of aging-related damage. When examined in the light of the new demographic data, age-dependent changes in gene expression in normal and diet-restricted flies can provide unique insight into the biological processes affected by aging and may help identify molecular pathways that regulate it.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. pletcher@bcm.tmc.edu
authors.forename: Scott D
authors.initials: SD
authors.lastname: Pletcher
authors.forename: Sergiy
authors.initials: S
authors.lastname: Libert
authors.forename: Danielle
authors.initials: D
authors.lastname: Skorupa
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology; D000818:Animals; D031204:Caloric Restriction; D004247:DNA / Q000235:genetics; D004032:Diet; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D017344:Genes, Insect; D008136:Longevity; D023421:Models, Animal; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software
chemical_list: D004247:DNA