title: Development of functional Haemophilus influenzae type b antibodies after vaccination.
abstract: Sixteen autologous stem cell transplant recipients received three vaccinations with conjugated haemophilus influenzae type b vaccine. Quantitative and qualitative aspects of the antibody response were studied. The vaccination schedule resulted in high antibody response rates and functional maturation of antibodies, as measured by antibody avidity and phagocytosis-inducing capacity.
authors.forename: Ankie M T
authors.initials: AM
authors.lastname: van der Velden
authors.forename: Anke M E
authors.initials: AM
authors.lastname: Claessen
authors.forename: Heleen
authors.initials: H
authors.lastname: van Velzen-Blad
authors.forename: Douwe H
authors.initials: DH
authors.lastname: Biesma
authors.forename: Ger T
authors.initials: GT
authors.lastname: Rijker
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood; D016667:Bacterial Capsules; D006192:Haemophilus Infections / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use*; D019741:Haemophilus influenzae type b / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use*; D033581:Stem Cell Transplantation / Q000009:adverse effects
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial