C2-symmetric bisprolinamide as a highly efficient catalyst for direct aldol reaction.
[reaction: see text] The catalytic activity of the prolinamide-type catalysts may be improved by introducing additional prolinamide moiety into the catalyst, while the enantioselectivity can still be maintained or further improved. A C2-symmetric bisprolinamide with two prolinamide moieties has been found to be an excellent catalyst for direct aldol reaction with more than doubled reactivity and better asymmetric induction than its monoprolinamide counterpart.
Samanta
Sampak
S
Department of Chemistry, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, Texas 78249-0698, USA.
Liu
Jinyun
J
Dodda
Rajasekhar
R
Zhao
Cong-Gui
CG
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; C116609:3-hydroxybutanal; D011392:Proline; C056291:prolinamide