title: [Neurological findings in a group of children and adolescents exposed and infected by HIV-1].
abstract: The CNS infection by HIV-1 in infancy could be present immediately after infection or became manifest later. Microcephalia, mental retardation, pyramidal signs, humor and behavioral disorders and antiretroviral therapy complications are common. This is an observational, sectional and descriptive study about findings on neurological examination of 173 patients in a group of children and adolescents infected and exposed to HIV-1 in perinatal period. Most of them had more than one neurological finding or different diagnosis. The more common findings were: encephalopathy, mental retardation, language delay, pyramidal signs, hyporeflexia. The neurological examination was abnormal in 67% of all patients even in seroreverters. We suggest that this group has a high risk to neurological disease and the development of co-morbidity is directly correlated to clinical deterioration by HIV-1 infection.
authors.affiliation: Hospital Santa Marcelina, e Ambulatório de AIDS-Infectopediatria, Universidade Federal de São Paulo, SP, Brasil. cri.rocha2@ig.com.br
authors.forename: Cristiane
authors.initials: C
authors.lastname: Rocha
authors.forename: Aída
authors.initials: A
authors.lastname: Gouvêa
authors.forename: Daisy
authors.initials: D
authors.lastname: Machado
authors.forename: Kelly
authors.initials: K
authors.lastname: Cunegundes
authors.forename: Suênia
authors.initials: S
authors.lastname: Beltrão
authors.forename: Fabiana
authors.initials: F
authors.lastname: Bononi
authors.forename: Regina Célia
authors.initials: RC
authors.lastname: Succi
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001938:Brazil; D020805:Central Nervous System Viral Diseases / Q000150:complications* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000209:etiology* / Q000503:physiopathology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D007223:Infant; D008297:Male; D012021:Reflex, Abnormal / Q000502:physiology; D012189:Retrospective Studies; D017678:Sex Distribution