title: [Effects of parathyroid hormone gene polymorphism on cardiovascular mortality].
abstract: It is well-known that secondary hyperparathyroidism of uremia influences not only bone and mineral metabolism but also cardiovascular complications. Here we reported the effects of the level of serum intact PTH and its gene polymorphism on cardiovascular and non-cardiovascular mortality in hemodialysis patients. We analyzed the association between clinico-molecular parameters and 3-year survival in 508 hemodialysis patients among whom 90 patients died. The multivariate Cox proportional hazards models showed that the presence of diabetes mellitus, levels of albumin and intact PTH, and BstB I genotype were indicated as independent predictors of cardiovascular mortality, whereas age and albumin level were indicated as those of non-cardiovascular mortality, suggesting that the level of intact PTH and its gene polymorphism effect cardiovascular mortality in hemodialysis patients.
authors.affiliation: Inoue Hospital.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tsujimoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tabata
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Hideki
authors.initials: H
authors.lastname: Tahara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shoji
authors.forename: Kayo
authors.initials: K
authors.lastname: Shinohara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000009:adverse effects*; D015996:Survival Rate
chemical_list: D010281:Parathyroid Hormone