Gold-catalyzed cycloisomerization of o-alkynylbenzaldehydes with a pendant unsaturated bond: [3 + 2] cycloaddition of gold-bound 1,3-dipolar species with dipolarophiles.
[reaction: see text] A new and novel Au-catalyzed cycloisomerization of ynals bearing a pendant unsaturated bond leading to synthetically valuable [6.7.n]-tricyclic compounds were developed. This study strongly supports the intermediacy of [3 + 2] cycloaddition proposed by DFT calculation and provides an easy access to key skeletons found in a variety of natural products.
Kim
Nakjoong
N
Department of Chemistry, Hanyang University, Sungdong-Gu, Seoul 133-791, Korea.
Kim
Yeongmi
Y
Park
Wooram
W
Sung
Dokyung
D
Gupta
Aruna Kumar
AK
Oh
Chang Ho
CH