[Polarographic behavior and determination of glimepiride].
OBJECTIVE
To establish a polarographic method of parallel catalytic hydrogen wave for determination of glimepiride.


METHODS
The catalytic wave of glimepiride in the presence of K2S2O8 was used to improve the analytical sensitivity. The rapid determination of glimepiride was done by linear single sweep polarography.


RESULTS
The catalytic hydrogen wave of glimepiride was measured at ca. -1.36 (vs SCE) in 0.09 mol x L(-1) Na2B4O7-KH2PO4 (pH 6.24 +/- 0.1) supporting electrolyte. When 1.0 x 10(-2) mol x L(-1) K2S2O8 was present, the current increased by 25 times, and the peak potentioal was unchanged, producing a more sensitive parallel catalytic hydrogen wave. The peak current of the parallel catalytic hydrogen wave was rectilinear to the glimepiride concentration in the range 1.0 x 10(-7) - 4.2 x 10(-5) mol x L(-1) (r = 0.9990, n = 9). The detection limit was 5.0 x 10(-8) mol x L(-1).


CONCLUSIONS
The proposed method could be applied to the determination of glimepiride in pharmaceuticals without preliminary separation.
Ma
Huai-ling
HL
Department of Chemistry, Shangqiu Normal College, Shangqiu 476000, China. mahuailing@eyou.com
Xu
Mao-tian
MT
Qu
Peng
P
Ma
Xiao-hua
XH
D002384:Catalysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000032:analysis / Q000652:urine; D008297:Male; D011048:Polarography / Q000379:methods*; D017680:Potassium Compounds / Q000032:analysis; D013431:Sulfates / Q000032:analysis; D013453:Sulfonylurea Compounds / Q000032:analysis* / Q000652:urine
D007004:Hypoglycemic Agents; D017680:Potassium Compounds; D013431:Sulfates; D013453:Sulfonylurea Compounds; C009007:potassium persulfate; C057619:glimepiride