t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma.
Strong expression of Forkhead box-P1 (FOXP1), a winged-helix transcription factor, has been identified as an independent prognostic factor in diffuse large B-cell lymphoma (DLBCL). However, possible mechanisms of deregulation of this gene, on 3p14.1, have yet to be elucidated. We have identified a breakpoint at the IGA1 gene in the immunoglobulin heavy chain (IGH) locus at 14q32 that was juxtaposed to the FOXP1 gene locus in a gastric DLBCL that showed strong expression of FOXP1. This may be one possible mechanism of deregulating FOXP1 expression by placing it under the control of IGH enhancers.
Fenton
James A L
JA
Department of Haematological Oncology, University of Leeds, United Kingdom. j.a.l.fenton@leeds.ac.uk
Schuuring
Ed
E
Barrans
Sharon L
SL
Banham
Alison H
AH
Rollinson
Sara J
SJ
Morgan
Gareth J
GJ
Jack
Andrew S
AS
van Krieken
J Han J M
JH
Kluin
Philip M
PM
D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14; D002893:Chromosomes, Human, Pair 3; D017931:DNA Primers; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D016393:Lymphoma, B-Cell / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D014178:Translocation, Genetic
D017931:DNA Primers; C486626:FOXP1 protein, human; D051858:Forkhead Transcription Factors; D012097:Repressor Proteins