Molecularly imprinted polymers: a bridge to advanced drug delivery.
Specific molecular recognition is a fundamental requirement of living systems on which processes as diverse as neural transmittance, respiration, immune defence, cellular differentiation and nutrition rely. It is therefore not surprising that scientists have invested huge amounts of time and effort into harnessing, and more recently mimicking, biological function. A number of synthetic approaches have been developed and one of the most promising of these is molecular imprinting. Molecular imprinted polymers have routinely been used, as robust and effective synthetic molecular receptors, in a diverse range of technologies. But it is perhaps in the area of drug delivery, in particular 'intelligent drug release' and 'magic bullet' drug targeting, that significant future opportunities lie.
Sellergren
Börje
B
INFU, Universität Dortmund, D-44221 Dortmund, Germany. borje@infu.uni-dortmund.de
Allender
Chris J
CJ
D040761:Biomimetic Materials / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D011108:Polymers