Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis.
Thioredoxin (TRX) is induced by many oxidative stresses. Serum TRX levels were significantly elevated in nonalcoholic steatohepatitis (NASH) patients, as compared to simple fatty liver (FL) patients or healthy controls. Serum TRX levels in NASH patients were significantly correlated with serum ferritin levels, but not with other variables. Removal of hepatic excess iron by phlebotomy significantly decreased the serum levels of TRX and ALT in NASH patient. Therefore, the pathogenesis of NASH may be associated with iron-related oxidative stress. The serum TRX level is a parameter for discriminating NASH from FL.
Nakashima
Toshiaki
T
Department of Internal Medicine, Saiseikai Kyoto Hospital, Imazato-minamihirao, Nagaoka-kyo, Kyoto 617-0814, Japan.
Sumida
Yoshio
Y
Furutani
Masanori
M
Hirohama
Akihisa
A
Okita
Mika
M
Mitsuyoshi
Hironori
H
Itoh
Yoshito
Y
Okanoue
Takeshi
T