Discriminant analysis to study trace elements in biomonitoring: an application on neurodegenerative diseases.
Quantification of 26 elements was performed in blood of patients affected by neurodegenerative pathologies, i.e., Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS), and of a control group to study the potential role of blood elements as markers for the different neurodegenerations. A multivariate discriminant analysis (stepwise method) was applied to determine the best set of variables to discriminate among subjects with different health status. Preliminary results show three classification functions of seven elements, namely Ca, Co, Cu, Fe, Ni, Pb and Zr.
Pino
Anna
A
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
Brescianini
Sonia
S
D'Ippolito
Cristina
C
Fagnani
Corrado
C
Alimonti
Alessandro
A
Stazi
Maria Antonietta
MA
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood; D016002:Discriminant Analysis; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood; D019636:Neurodegenerative Diseases / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood; D014131:Trace Elements / Q000097:blood*
D014131:Trace Elements