Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds from 4-phenylsulfonyl tetrafluoropyridine.
[Reaction: see text]. Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido[2,3-b]pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.
Baron
Aurelie
A
Department of Chemistry and Chemical Crystallography Group, University of Durham, South Road, Durham, DH1 3LE, United Kingdom.
Sandford
Graham
G
Slater
Rachel
R
Yufit
Dmitry S
DS
Howard
Judith A K
JA
Vong
Antonio
A
D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis*; D011725:Pyridines / Q000737:chemistry*
D011719:Pyrazines; D011725:Pyridines