Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis.
Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.
Kirkpatrick
William R
WR
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, Texas 78229-3900, USA. kirkpatrick@uthscsa.edu
Vallor
Ana C
AC
McAtee
Robert K
RK
Ryder
Neil S
NS
Fothergill
Annette W
AW
Rinaldi
Michael G
MG
Patterson
Thomas F
TF
D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000008:administration & dosage*; D011817:Rabbits; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000666:Amphotericin B; D000077291:Terbinafine