title: Restrictive lung disease and serum TGF-beta1 in thalassemia major children.
abstract: A cross sectional study was performed in 21 thalassemia major (TM) children at King Chulalongkorn Memorial Hospital during March to August, 2003 to determine whether restrictive lung disease (RLD) was related to serum transforming growth factor-beta 1 (TGF-beta1). All studied patients (57% female, age 11.2 +/- 2.6 yrs, duration of transfusion 7.7 +/- 4.1 yrs) never had desferoxamine treatment and their pulmonary function, serum ferritin and serum TGF-beta1 were evaluated. Five (24%) had RLD. RLD patients had significantly longer durations of transfusion and higher serum ferritin levels than non-RLD patients (9.1 +/- 1.9 vs 5.5 +/- 3.2 yrs; p = 0.03 and 3,816.6 +/- 1,715.9 vs 2,084.5 +/- 1,504.8 ng/ml; p = 0.04, respectively). TM children had lower serum TGF-beta1 levels than normal children (7.9 vs 78.8 pg/ml; p < 0.001). The serum TGF-beta1 level was not different between RLD and non-RLD patients (13.3 vs 4.2 pg/ml; ns), concluding that RLD was related to longer duration of transfusion and higher serum ferritin but not related to serum TGF-beta1 levels.
authors.affiliation: Division of Pulmonology and Critical Care Medicine, King Chulalongkorn Memorial Hospital, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. suchadacu@hotmail.com
authors.forename: Suchada
authors.initials: S
authors.lastname: Sritippayawan
authors.forename: Piyachat
authors.initials: P
authors.lastname: Lekhanont
authors.forename: Chanthana
authors.initials: C
authors.lastname: Harnruthakorn
authors.forename: Rujipat
authors.initials: R
authors.lastname: Samransamruajkit
authors.forename: Jitladda
authors.initials: J
authors.lastname: Deerojanawong
authors.forename: Panya
authors.initials: P
authors.lastname: Seksarn
authors.forename: Yong
authors.initials: Y
authors.lastname: Poovorawan
authors.forename: Nuanchan
authors.initials: N
authors.lastname: Prapphal
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001803:Blood Transfusion; D002648:Child; D002669:Child Welfare; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008171:Lung Diseases / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D008297:Male; D013785:Thailand / Q000453:epidemiology; D014109:Total Lung Capacity; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1; D017086:beta-Thalassemia / Q000097:blood* / Q000150:complications*
chemical_list: D015415:Biomarkers; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D005293:Ferritins