title: Using computational modeling to drive the development of targeted therapeutics.
abstract: Computational biology is impacting drug design and has the potential to revolutionize the drug development process. Here, we describe how data-driven computational models can optimize the design of targeted therapeutics to yield improved safety and efficacy. We propose that, in the future, this approach will improve drug discovery, clinical development, diagnosis and treatment.
authors.affiliation: Merrimack Pharmaceuticals Inc, Cambridge, MA 02142, USA. unielsen@merrimackpharma.com
authors.forename: Ulrik B
authors.initials: UB
authors.lastname: Nielsen
authors.forename: Brigit
authors.initials: B
authors.lastname: Schoeberl
mesh_terms: D019295:Computational Biology / Q000379:methods / Q000639:trends*; D003198:Computer Simulation; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006801:Humans