Familial Dandy-Walker syndrome: a case report supporting an autosomal inheritance.
BACKGROUND
We report an isolated pedigree in which a consanguineous couple had twin sons with Dandy-Walker malformation (DWM). The mother is similarly affected with the disorder.


CONCLUSIONS
DWM is an abnormality of the central nervous system, which leads to hydrocephalus and is associated with other abnormalities.


CONCLUSIONS
Inheritance of the disorder remains controversial, with the majority perceived to be sporadic cases. This report suggests an autosomal inheritance.
Bragg
Thomas W H
TW
Department of Neurosurgery, Diana Princess of Wales Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK. twhbragg@hotmail.com
St George
Edward J
EJ
Wynne-Jones
Guy A
GA
Hockley
Anthony
A
Morton
Jenny E V
JE
D000328:Adult; D003616:Dandy-Walker Syndrome / Q000235:genetics*; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006801:Humans; D006849:Hydrocephalus; D007223:Infant; D008297:Male; D011247:Pregnancy