title: Synthesis of 5-aza-7-deazaguanine nucleoside derivatives as potential anti-flavivirus agents.
abstract: Coupling suitable sugars (D- or L-ribofuranose, 2' or 3-deoxysugar, branched sugars) with 2-aminoimidazo[1,2-a]-s-triazin-4-one was carried out using the different reaction conditions: 1) condensation in the presence of sodium hydride; or 2) condensation using Vorbrüggen's methods. The 5-aza- 7-deazaguanine nucleoside analogues obtained were evaluated in cell culture experiments for the inhibition of the replication of a number of RNA viruses, including BVDV, YFV, and WNV.
authors.affiliation: Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
authors.forename: D
authors.initials: D
authors.lastname: Dukhan
authors.forename: F
authors.initials: F
authors.lastname: Leroy
authors.forename: J
authors.initials: J
authors.lastname: Peyronnet
authors.forename: E
authors.initials: E
authors.lastname: Bosc
authors.forename: D
authors.initials: D
authors.lastname: Chaves
authors.forename: M
authors.initials: M
authors.lastname: Durka
authors.forename: R
authors.initials: R
authors.lastname: Storer
authors.forename: P
authors.initials: P
authors.lastname: La Colla
authors.forename: F
authors.initials: F
authors.lastname: Seela
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D005416:Flavivirus / Q000378:metabolism*; D018177:Flavivirus Infections / Q000188:drug therapy*; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006801:Humans; D008956:Models, Chemical; D009705:Nucleosides / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000737:chemistry; D012263:Ribonucleosides / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D011741:Pyrimidine Nucleosides; D012263:Ribonucleosides; D006151:Guanosine; D006147:Guanine; C066856:7-deazaguanine