title: Radical radiotherapy alone for glomus jugulare and tympanicum tumours.
abstract: The management of glomus jugulare and tympanicum tumours is controversial due the long natural history and morbidity associated with intervention. We report the experience of radical radiotherapy (RT) alone for these tumours. Between 1965 and 1987, 49 patients received RT. Median age at presentation was 55 years (range, 23-82). Common presentations were deafness in 27 patients, tinnitus in 25 and cranial nerve palsies in 18. RT was given as a 2D simulator-planned wedge pair in the majority with a median dose of 45 Gy (range, 37.5-50.0) in 15 or 16 fractions over 21 days (range, 20-26). Median follow-up was 7.4 years (range, 2.0-23.4). At 6 months post-RT, complete clinical response was seen in 38 patients, partial response in 4, no response in 1 and no data were available for 6. At both 5 and 10 years, 92% of patients were recurrence-free and cancer-specific survival was 96%. There were no reports of radionecrosis. Although tumour eradication is not the aim, RT can achieve good local control, survival and symptom relief without the significant morbidity that can be associated with radical surgery. Therefore, RT alone has a significant role in the management of these tumours.
authors.affiliation: Department of Clinical Oncology, Christie Hospital, Manchester, UK.
authors.forename: Laura Shelley
authors.initials: LS
authors.lastname: Pemberton
authors.forename: Ric
authors.initials: R
authors.lastname: Swindell
authors.forename: Andrew John
authors.initials: AJ
authors.lastname: Sykes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004307:Dose-Response Relationship, Radiation; D004428:Ear Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005925:Glomus Jugulare Tumor / Q000473:pathology / Q000532:radiotherapy*; D043604:Glomus Tympanicum Tumor / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome