title: Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis.
abstract: Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, Texas 78229-3900, USA. kirkpatrick@uthscsa.edu
authors.forename: William R
authors.initials: WR
authors.lastname: Kirkpatrick
authors.forename: Ana C
authors.initials: AC
authors.lastname: Vallor
authors.forename: Robert K
authors.initials: RK
authors.lastname: McAtee
authors.forename: Neil S
authors.initials: NS
authors.lastname: Ryder
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000008:administration & dosage*; D011817:Rabbits; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000666:Amphotericin B; D000077291:Terbinafine