title: Hypercoagulability markers in young asymptomatic heterozygous carriers of factor V Leiden (G1691A) or prothrombin (G20210A) variant.
abstract: BACKGROUND
  Mutations in factor V (factor V Leiden-G1691A) and prothrombin (G20210A) genes are important risk factors for thrombophilia due to their high incidence in patients with thromboembolic events, especially among the young. However, it is not clear if levels of hypercoagulability markers are significantly altered in asymptomatic young carriers of factor V Leiden or prothrombin G20210A.
  
  
  METHODS
  Hemostatic status of 32 asymptomatic young individuals carrying these mutations and of 18 normal control individuals was investigated through the determination of plasma thrombomodulin (TM), prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT) and D-dimer.
  
  
  RESULTS
  No significant differences were observed in these hemostatic markers when comparing groups of individuals carrying mutations and the control group.
  
  
  CONCLUSIONS
  Analysis of these results leads to the conclusion that the presence of these mutations, in the absence of acquired risk factors, does not constantly predispose these young carriers to a state of hypercoagulability.
authors.affiliation: Faculty of Pharmacy, Federal University of Minas Gerais-Belo Horizonte/Minas Gerais, Brazil.
authors.forename: Lara Carvalho
authors.initials: LC
authors.lastname: Godoi
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Fernandes
authors.forename: Lauro Mello
authors.initials: LM
authors.lastname: Vieira
authors.forename: Daniela Amorim
authors.initials: DA
authors.lastname: Melgaço
authors.forename: Marcos
authors.initials: M
authors.lastname: de Bastos
authors.forename: Monica de F
authors.initials: Mde F
authors.lastname: Ribeiro
authors.forename: Maria das Graças
authors.initials: Md
authors.lastname: Carvalho
authors.forename: Luci Maria Sant Ana
authors.initials: LM
authors.lastname: Dusse
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011516:Prothrombin / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin