[Effects of bFGF on the nasal mucosa after endoscopic sinus surgery].
OBJECTIVE
To explore the effect of bFGF on nasal mucosa after ESS.


METHODS
Ten cases of type I phase 3 chronic sinusitis were selected randomly. For each patient bFGF was intranasally used in one single nasal cavity a week after ESS. The other cavity, treated with nothing, was used as control. Scanning electron microscopy examinations of middle meatus mucosa were made 1,1. 5, 2 and 3 month after ESS.


RESULTS
In the first month after operation ciliated cells in the mucosa swelled and lined unregularly, the cilia exfoliated. From the sixth week to the 2nd month ciliated cells lined more regularly and the number of cells as well as the density of cilia increased obviously but the cilia aligned in disturbance. In the 3rd month after ESS, the swell of mucosa subside completely and cilia of columnar epithelial cells moved in one direction,which meant the cilia recover the function.


CONCLUSIONS
bFGF can speed up the recovery of nasal mucosa both in number and in function after ESS.
Mu
Junshang
J
Department of Otorhinolaryngology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China. huanbao0001@163.com
Zhang
Xun
X
Cheng
Jun
J
Yuan
Yongyi
Y
D000293:Adolescent; D000328:Adult; D004724:Endoscopy; D004847:Epithelial Cells / Q000187:drug effects; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology*; D012852:Sinusitis / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
D016222:Fibroblast Growth Factor 2