title: Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China.
abstract: Air pollution has been suggested to cause genetic damage from investigations of many biological markers that measure cytogenetic damage in humans. Here, we evaluated the genotoxic effects of ambient air pollution by investigating the extent of cytogenetic damage in human blood lymphocytes from rural and industrial female residents of Shenyang city, China, using micronuclei assays and polymorphic analyses of metabolic enzyme and DNA repair genes. After adjustment for potential confounding factors including DNA polymorphisms, industrial female residents were found to have a higher micronuclei frequency. These results provide evidence that micronuclei assays are a sensitive indicator to air pollution-induced genotoxic effects in humans.
authors.affiliation: Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan. h.iskw@med.id.yamagata-u.ac.jp <h.iskw@med.id.yamagata-u.ac.jp>
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Piao
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Duan
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mingyue
authors.initials: M
authors.lastname: Ma
authors.forename: Haishan
authors.initials: H
authors.lastname: Li
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Shigekatsu
authors.initials: S
authors.lastname: Sakai
authors.forename: Jinshan
authors.initials: J
authors.lastname: Cui
authors.forename: Toru
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yokoyama
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D002274:Carcinogens, Environmental / Q000032:analysis / Q000633:toxicity*; D002681:China; D005260:Female; D005449:Fluorenes / Q000032:analysis / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis / Q000633:toxicity*; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D014504:Urban Health
chemical_list: D000393:Air Pollutants; D002274:Carcinogens, Environmental; D005449:Fluorenes; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons; C006703:benzo(b)fluoranthene