[Serum level of soluble forms of membranous antigens of immune system cells in carriers of virus hepatitis G markers].
The levels of soluble CD38 (sCD38), CD50 (sCD50), and CD95 (sCD95) antigens and HLA class I (sHLA-I) were determined in the serum samples from persons infected with hepatitis G virus (HGV). HGV monoinfection was accompanied by a rise in the serum content of sCD38, sCD50, and sCD95 antigens. The serum presence of HGV RNA and anti-E2 HGV antibodies was characterized by the normal content of sCD38 and sCD95 while the level of sCD50 was elevated and the serum content of sHLA-I was decreased. If the serum contained only anti-E2 HGV antibodies, the level of sCD50 remained increased 4-fold. It is suggested that the higher adhesion-inhibiting level of sCD50 is a reason of a weak immune response to HGV and hence of a long HGV persistence in the body.
Kravchenko
G A
GA
Novikov
D V
DV
Ptitsyna
Iu S
IuS
Novikov
V V
VV
D015703:Antigens, CD / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D018178:Flaviviridae Infections / Q000097:blood* / Q000821:virology; D029407:GB virus C / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006680:HLA Antigens / Q000097:blood*; D006508:Hepatitis Antibodies / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000821:virology; D012367:RNA, Viral / Q000097:blood; D012995:Solubility; D014759:Viral Envelope Proteins / Q000276:immunology; D019014:fas Receptor / Q000097:blood*
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006680:HLA Antigens; D006508:Hepatitis Antibodies; C483616:ICAM3 protein, human; D012367:RNA, Viral; D014759:Viral Envelope Proteins; D019014:fas Receptor; C107619:glycoprotein E2, GB virus C