title: Cytomegalovirus cholangitis and pancreatitis in an immunocompetent patient.
abstract: Cholangitis and pancreatitis associated with cytomegalovirus (CMV) infection in an immunocompetent patient is reported. Endoscopic retrograde cholangiography performed on a 55-year-old man for evaluation of the cause of jaundice and liver dysfunction revealed a distal focal irregular narrowing of the common bile duct. Microscopic findings of the resected specimen showed chronic cholangitis and CMV pancreatitis. Immunohistochemistry disclosed that epithelial cells in the inflamed bile duct were positive for CMV antigen, which was compatible with CMV cholangitis. Inflammation of the biliary tract or pancreas by CMV has been commonly reported as a complication in immunocompromised patients. Our report appears to be a rare case, but suggests that CMV cholangitis or pancreatitis should be considered in the differential diagnoses of common bile duct stenosis or pancreatitis even in immunocompetent individuals.
authors.affiliation: Department of Gastroenterology, Shinnittetsu Muroran General Hospital, 1-45 Chiribetsu-cho, Muroran, 050-0076, and Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan.
authors.forename: Takatomi
authors.initials: T
authors.lastname: Oku
authors.forename: Masahiro
authors.initials: M
authors.lastname: Maeda
authors.forename: Eriko
authors.initials: E
authors.lastname: Waga
authors.forename: Yuko
authors.initials: Y
authors.lastname: Wada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nagamachi
authors.forename: Miri
authors.initials: M
authors.lastname: Fujita
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagashima
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D002761:Cholangitis / Q000150:complications* / Q000175:diagnosis / Q000821:virology*; D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000175:diagnosis; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications* / Q000175:diagnosis / Q000821:virology*