Prior clopidogrel use and outcome of acute coronary syndrome.
BACKGROUND
Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.


OBJECTIVE
To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.


METHODS
Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.


METHODS
Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.


RESULTS
Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).


CONCLUSIONS
No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.
Soiza
Roy L
RL
Leslie
Stephen J
SJ
D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D003327:Coronary Disease / Q000188:drug therapy*; D006801:Humans; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin