Treatment delay and the risk of prolonged status epilepticus.
Factors contributing to the duration of a single convulsive seizure > 5 minutes were analyzed in 157 children. The medically treated episodes were compared with seizure episodes resolving without treatment (n = 27). Major differences were in age (p = 0.016) and etiology (p = 0.003), and the association between treatment delay and response became significant after 30 minutes when this was analyzed as a single variable (p = 0.003) in Cox regression analysis.
Eriksson
K
K
Pediatric Research Centre, Medical School, University of Tampere, Tampere, Finland. kai.eriksson@uta.fi
Metsäranta
P
P
Huhtala
H
H
Auvinen
A
A
Kuusela
A-L
AL
Koivikko
M
M
D000285:Administration, Rectal; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects; D002675:Child, Preschool; D002985:Clinical Protocols / Q000592:standards*; D018450:Disease Progression; D042241:Early Diagnosis; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000009:adverse effects; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D012189:Retrospective Studies; D055502:Secondary Prevention; D013226:Status Epilepticus / Q000503:physiopathology / Q000517:prevention & control*; D013874:Thiopental / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome
D000927:Anticonvulsants; D001569:Benzodiazepines; D010672:Phenytoin; C043114:fosphenytoin; D013874:Thiopental; D010634:Phenobarbital