title: Absolute configuration of TPU-0043, a pentaene macrolide from Streptomyces sp.
abstract: An antifungal pentaene macrolide TPU-0043 was isolated from Streptomyces sp. TP-A0625. The absolute configuration of TPU-0043 was determined to be 2R-(n-butyl)-16-methyl-3S,5S,7S,9R,11R,13R,15S,26S, 27R-nonahydroxyoctacosa-16,18,20,22,24-pentaenoic acid, 27-lactone, by X-ray crystallography of its 13-p-bromobenzenesulfonyl derivative.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: In
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Ishida
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamakawa
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Onaka
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Furumai
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011073:Polyamines; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C506324:2R-(n-butyl)-16-methyl-3S,5S,7S,9R,11R,13R,15S,26S, 27R-nonahydroxyoctacosa-16,18,20,22,24-pentaenoic acid, 27-lactone; D000935:Antifungal Agents; D018942:Macrolides; D011073:Polyamines