Bone regeneration in osseous defects using a resorbable nanoparticular hydroxyapatite.
OBJECTIVE
This animal study examined the de novo bone formation in bony defects following the insertion of autogenous bone alone versus an injectable nanoparticle hydroxyapatite alone and in combination with 25% autogenous bone. The regenerative potentials of the tested materials were compared with each other.


METHODS
A model with biological similarity to humans with regard to bone regeneration was a prerequisite for the transferability of the results to clinical practice. Therefore, the adult domestic pig was the animal of choice. A total observation period of 6 months was selected. Microradiographic and histologic evaluation of the bone specimens was completed at 8 defined times.


RESULTS
Microradiography indicated mineralization rates in the 2 bone substitute groups that were not significantly lower than those found in the autogenous bone group. Histologically, there was suitable osseointegration and osteoconduction of the used material. Complete resorption of the nanoparticle hydroxyapatite had taken place after 12 weeks.


CONCLUSIONS
It can be concluded that the evaluated nanoparticular hydroxyapatite met the clinical requirements for a bone substitute material within the limits of this experimental setting. Due to its microstructure, complete resorption took place during the course of this study.
Thorwarth
Michael
M
Department of Oral and Maxillofacial Surgery/Plastic Surgery, University of Jena, Erlanger Allee 101, D-07747 Jena, Germany. michael@thorwarth-online.de
Schultze-Mosgau
Stefan
S
Kessler
Peter
P
Wiltfang
Joerg
J
Schlegel
Karl Andreas
KA
D020341:Absorbable Implants; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods; D005260:Female; D006882:Hydroxyapatites / Q000737:chemistry / Q000494:pharmacology*; D008852:Microradiography; D023421:Models, Animal; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology*; D012886:Skull / Q000000981:diagnostic imaging / Q000601:surgery* / Q000637:transplantation; D034421:Sus scrofa
D018786:Bone Substitutes; D006882:Hydroxyapatites