Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase.
Wu
Jiaquan
J
Department of Chemistry, Box H, Brown University, Providence, RI 02912-9108, USA.
He
Weiguo
W
Khosla
Chaitan
C
Cane
David E
DE
D018360:Crystallography, X-Ray; D006868:Hydrolysis; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D048630:Polyketide Synthases / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D018942:Macrolides; C008517:methymycin; D048630:Polyketide Synthases; C003145:picromycin