title: [Steroid compounds from far Eastern starfishes Henricia aspera and H. tumida].
abstract: Six new natural compounds were isolated from two Far Eastern starfish species, Henricia aspera and H. tumida, collected in the Sea of Okhotsk. Two new glycosylated steroid polyols were obtained from H. aspera: asperoside A and asperoside B, which were shown to be (20R,24R,25S)-3-O-(2,3-di-O-methyl-beta-D-xylopyranosyl)-24-methyl-5alpha-cholest-4-ene-3beta,6beta,8,15a,16beta,26-hexaol and (20R,24R,25S,22E)-3-O-(2,4-di-O-methyl-beta-D-xylopyranosyl)-24-methyl-5alpha-cholest-22-ene-3beta,4beta,6beta,8,15alpha,26-hexaol, respectively. Two other glycosylated polyols, tumidoside A, with the structure elucidated as (20R,22E)-3-O-(2,4-di-O-methyl-beta-D-xylopyranosyl)-26,27-di-nor-24-methyl-5alpha-cholest-22-ene-3beta,4beta,6beta,8,15alpha,25-hexaol, and tumidoside B, whose structure was elucidated as (20R,24S)-3-O-(2,3-di-O-methyl-beta-D-xylopyranosyl)-5alpha-cholestan-3beta,4beta,6beta,8,15alpha,24-hexaol, were isolated from the two starfish species. (20R,24S)-Salpha-Cholestan-3beta,6beta,15alpha,24-tetraol and (20R,24S)-5alpha-cholestan-3beta,6beta,8,15alpha,24-pentaol were identified only in H. tumida. The known monoglycosides henricioside H1 and laeviuscolosides H and G were also identified in both species.
authors.forename: E V
authors.initials: EV
authors.lastname: Levina
authors.forename: A I
authors.initials: AI
authors.lastname: Kalinovskiĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Stonik
authors.forename: P S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: P V
authors.initials: PV
authors.lastname: Andriiashchenko
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009792:Oceans and Seas; D012426:Russia; D021241:Spectrometry, Mass, Electrospray Ionization; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013081:Sperm Motility / Q000187:drug effects; D013215:Starfish / Q000378:metabolism*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047269:Strongylocentrotus / Q000187:drug effects / Q000254:growth & development; D015053:Zygote / Q000166:cytology / Q000187:drug effects
chemical_list: D013256:Steroids