An update on the treatment options for gout and calcium pyrophosphate deposition.
Gout and calcium pyrophosphate deposition disease are two common causes of inflammatory joint disease. Despite differences underlying their pathogenesis, their clinical presentation and treatment share some common features. Optimal treatment for both requires prompt resolution of acute synovitis, reduction of chronic joint damage and management of associated conditions. Available therapeutic interventions and future strategies are reviewed in this article.
Choy
Gregory
G
Division of Rheumatology, University of Toronto, Sunnybrook and Women's College Health Science Centre, M1-401, Toronto, ON, M4N 3M5, Canada.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000188:drug therapy / Q000209:etiology; D002805:Chondrocalcinosis / Q000188:drug therapy* / Q000473:pathology; D003078:Colchicine / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000069465:Febuxostat; D006073:Gout / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D006074:Gout Suppressants / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015337:Multicenter Studies as Topic; D011339:Probenecid / Q000008:administration & dosage / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use; D014527:Uric Acid / Q000097:blood / Q000378:metabolism; D014528:Uricosuric Agents / Q000008:administration & dosage / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004791:Enzyme Inhibitors; D006074:Gout Suppressants; D013844:Thiazoles; D014528:Uricosuric Agents; D000069465:Febuxostat; D014527:Uric Acid; D000493:Allopurinol; D000324:Adrenocorticotropic Hormone; D014969:Xanthine Oxidase; D011339:Probenecid; D003078:Colchicine