Anaesthesia and the acute phase protein response in children undergoing circumcision.
Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anaesthesia with mask, n=20), group 3 (ketamine, n=20), group 4 (local anaesthesia, n=35). Blood samples were obtained, 24 hours before circumcision, after premedication, and 24 hours after circumcision. CRP and albumin before circumcision were comparable for all groups. There was no increase in CRP, and albumin remained steady throughout the study. No difference was observed among the groups, and related to anaesthesia. No responsiveness may be explained with the size of injured tissue or anatomical and histological type of preputium.
Buyukkocak
Unase
U
Department of Anaesthesiology and Ranimation, School of Medicine, Kirikkale University, Turkey. unaseb@yahoo.com
Caglayan
Fatma
F
Caglayan
Osman
O
Basar
Murat
M
Cakmak
Murat
M
Batislam
Ertan
E
Ulusoy
Sevgi
S
D000209:Acute-Phase Proteins; D000210:Acute-Phase Reaction; D000293:Adolescent; D000758:Anesthesia / Q000009:adverse effects*; D000768:Anesthesia, General / Q000009:adverse effects; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D000772:Anesthesia, Local / Q000009:adverse effects; D002097:C-Reactive Protein / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002944:Circumcision, Male; D006801:Humans; D007223:Infant; D008297:Male; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism*
D000209:Acute-Phase Proteins; D012709:Serum Albumin; D002097:C-Reactive Protein