title: Synthesis, characterization and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with bidentate Schiff bases derived by heterocyclic ketone.
abstract: A series of metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized with newly prepared biologically active ligands. These ligands were prepared by the condensation of 4-amino-5-mercapto-3-methyl-s-triazole (AMMT), 4-Amino-3-ethyl-5-mercapto-s-triazole (AEMT) with 2-acetylpyridine. The structure of the complexes have been proposed by elemental analyses, spectroscopic data i.e. IR, 1H NMR, electronic and magnetic measurements. Thermal studies of the complexes are also reported. Antibacterial activities of 10 complexes have been studied in vitro. Heterocyclic bidentate Schiff bases were associated with substantially higher antibacterial activities than some commercial antibiotics.
authors.affiliation: Department of Chemistry, Kurukshetra University, Kurukshetra, 136119 Haryana, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Singh
authors.forename: Manjeet Singh
authors.initials: MS
authors.lastname: Barwa
authors.forename: Parikshit
authors.initials: P
authors.lastname: Tyagi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D003035:Cobalt / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000187:drug effects; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry / Q000378:metabolism; D012545:Schiff Bases / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis / Q000378:metabolism; D017967:Zinc Compounds / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D007659:Ketones; D008024:Ligands; D012545:Schiff Bases; D014230:Triazoles; D017967:Zinc Compounds; D003035:Cobalt; D003300:Copper; D009532:Nickel