title: Body mass index predicts the incidence of radiation pneumonitis in breast cancer patients.
abstract: In patients receiving breast radiotherapy, the risk of radiation pneumonitis has been associated with the volume of irradiated lung, and concomitant methotrexate, paclitaxel, and tamoxifen therapy. Many of the studies of radiation pneumonitis are based on estimates of pulmonary risk using central lung distance that is calculated using two-dimensional techniques. With the treatment of internal mammary nodes and three-dimensional treatment planning for breast cancer becoming increasingly more common, there is a need to further consider the impact of dose-volume metrics in assessing radiation pneumonitis risk. We herein present a case control study assessing the impact of clinical and dose-volume metrics on the development of radiation pneumonitis in patients receiving sequential chemotherapy and local-regional radiotherapy.
authors.affiliation: Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA. Aallen@lroc.harvard.edu
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Allen
authors.forename: Robert G
authors.initials: RG
authors.lastname: Prosnitz
authors.forename: Randall K
authors.initials: RK
authors.lastname: Ten Haken
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Normolle
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yu
authors.forename: Su-min
authors.initials: SM
authors.lastname: Zhou
authors.forename: Robin
authors.initials: R
authors.lastname: Marsh
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Pierce
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000532:radiotherapy*; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D015994:Incidence; D008168:Lung / Q000528:radiation effects*; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D017564:Radiation Pneumonitis / Q000453:epidemiology* / Q000209:etiology*; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D012189:Retrospective Studies; D016387:Women's Health