New trends in synthesis of pyrazole nucleosides as new antimetabolites.
Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.
Elgemeie
Galal H
GH
Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt.
Zaghary
Wafaa A
WA
Amin
Kamelia M
KM
Nasr
Tamer M
TM
D000577:Amides; D000963:Antimetabolites / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004267:DNA Viruses; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D012266:Ribose; D013329:Structure-Activity Relationship; D014777:Virus Diseases / Q000188:drug therapy*
D000577:Amides; D000963:Antimetabolites; D000998:Antiviral Agents; D011720:Pyrazoles; D012263:Ribonucleosides; C031280:pyrazole; C002997:pyrazofurin; D012266:Ribose