Efficacy of penicillin versus cefdinir in eradication of group A streptococci and tonsillar flora.
Core tonsillar cultures were obtained from 40 children with recurrent tonsillitis treated with either penicillin or cefdinir. Group A beta-hemolytic streptococci were isolated from 11 penicillin- and 3 cefdinir-treated (P < 0.001) patients. beta-Lactamase producers were recovered from 17 penicillin- and 3 cefdinir-treated (P < 0.01) patients. Inhibiting alpha-hemolytic streptococci were isolated less often from penicillin-treated patients than from cefdinir-treated patients.
Brook
Itzhak
I
Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA. ib6@georgetown.edu
Foote
Perry A
PA
D000077525:Cefdinir; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000382:microbiology*; D010406:Penicillins / Q000494:pharmacology* / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000187:drug effects*; D014069:Tonsillitis / Q000188:drug therapy*
D002511:Cephalosporins; D010406:Penicillins; D000077525:Cefdinir