Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines.
Eight 5-alkynyl-2'deoxyuridines containing different bulky substituents have been prepared and tested against HSV-1 in Vero cells. The compounds show positive antiviral activity. There is no obvious correlation between activity and substituent size. The nature of the linker between uracil and a substituent appears to be more important for antiviral properties: nucleosides containing arylethynyl groups show higher activity.
Pchelintseva
A A
AA
Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Skorobogatyj
M V
MV
Petrunina
A L
AL
Andronova
V L
VL
Galegov
G A
GA
Astakhova
I V
IV
Ustinov
A V
AV
Malakhov
A D
AD
Korshun
Vladimir A
VA
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002522:Chlorocebus aethiops; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008956:Models, Chemical; D018139:Simplexvirus / Q000378:metabolism*; D014498:Uracil / Q000737:chemistry; D014709:Vero Cells
D000998:Antiviral Agents; D014498:Uracil; D003857:Deoxyuridine