Flies on steroids: the interplay between ecdysone and insulin signaling.
In the fruit fly Drosophila melanogaster, the insulin and ecdysone signaling pathways have long been known to regulate growth and developmental timing, respectively. Recent findings reveal that crosstalk between these pathways allows coordination of growth and developmental timing and thus determines final body size.
Orme
Mariam H
MH
Growth Regulation Laboratory, Cancer Research UK London Research Institute, PO Box 123, 44 Lincolns Inn Fields, London WC2A 3PX, United Kingdom.
Leevers
Sally J
SJ
D000818:Animals; D049628:Body Size; D004331:Drosophila melanogaster / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D004440:Ecdysone / Q000378:metabolism*; D004441:Ecdysterone / Q000096:biosynthesis / Q000378:metabolism*; D005216:Fat Body / Q000254:growth & development; D007328:Insulin / Q000502:physiology*; D007329:Insulin Antagonists / Q000378:metabolism; D007814:Larva / Q000254:growth & development; D008675:Metamorphosis, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction
D007328:Insulin; D007329:Insulin Antagonists; D004440:Ecdysone; D004441:Ecdysterone; D019869:Phosphatidylinositol 3-Kinases