title: Live birth after IVF in a 46-year-old woman.
abstract: Pregnancies after IVF have been reported in women aged > or =44 years, but nobody older than 45 years at oocyte retrieval delivered. We report a case of birth of a healthy child after IVF in a 46-year-old infertile woman. Ovarian stimulation was performed with clomiphene citrate, 150 mg daily for 5 days. Three oocytes were retrieved and one embryo was replaced. The patient delivered a healthy male infant after Caesarean section at 39 weeks. A successful pregnancy after IVF with homologous oocytes can be achieved in women older than 45 years. At this age IVF is not a cost-effective treatment compared with oocyte donation, but it may be offered in countries in which gamete donation is forbidden.
authors.affiliation: Tecnobios Procreazione, Centre for Reproductive Health, Via Dante 15, I-40125 Bologna, Italy. dalprato@tecnobiosprocreazione.it
authors.forename: Luca
authors.initials: L
authors.lastname: Dal Prato
authors.forename: Andrea
authors.initials: A
authors.lastname: Borini
authors.forename: Monica
authors.initials: M
authors.lastname: Cattoli
authors.forename: Maria Serena
authors.initials: MS
authors.lastname: Preti
authors.forename: Lucia
authors.initials: L
authors.lastname: Serrao
authors.forename: Carlo
authors.initials: C
authors.lastname: Flamigni
mesh_terms: D000367:Age Factors; D002996:Clomiphene / Q000494:pharmacology; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000628:therapy; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D009865:Oocytes / Q000166:cytology / Q000378:metabolism; D010053:Ovary / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk
chemical_list: D002996:Clomiphene