title: [Cardiac ion channel disorders--diagnosis and treatment].
abstract: BACKGROUND
  Inherited arrhythmogenic disorders are a group of genetically determined diseases characterised by ventricular tachyarrhythmias sometimes leading to sudden death. The molecular bases of these disorders are mutations in genes coding for various cardiac ion channels. The most common cardiac ion channel disease is the long QT syndrome. This syndrome is rare, but probably more common in Norway than previously expected. We have recently started genetic testing for cardiac ion channel disorders at Rikshospitalet University Hospital in Oslo. This review describes the current understanding of the etiology, prognosis and management of cardiac ion channel disorders, based on literature and our own clinical experience.
  
  
  CONCLUSIONS
  Cardiac ion channel disorders may lead to sudden cardiac death. Prophylactic and life-saving therapies are available for many of these disorders. Therapy and risk stratification depend on the clinical presentation, the ECG pattern, and which gene is mutated. Genetic testing offers the opportunity to exclude individual family members as mutation carriers.
authors.affiliation: Hjertemedisinsk avdeling, Rikshospitalet, 0027 Oslo. kristina.haugaa@rikshospitalet.no
authors.forename: Kristina Hermann
authors.initials: KH
authors.lastname: Haugaa
authors.forename: Knut Erik
authors.initials: KE
authors.lastname: Berge
authors.forename: Andreas
authors.initials: A
authors.lastname: Früh
authors.forename: Ole-Gunnar
authors.initials: OG
authors.lastname: Anfinsen
authors.forename: Marianne
authors.initials: M
authors.lastname: Arnestad
authors.forename: Maria
authors.initials: M
authors.lastname: Hallerud
authors.forename: Knut
authors.initials: K
authors.lastname: Gjesdal
authors.forename: Trond P
authors.initials: TP
authors.lastname: Leren
authors.forename: Jan Peder
authors.initials: JP
authors.lastname: Amlie
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D002037:Bundle-Branch Block / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D002648:Child; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D009154:Mutation; D010641:Phenotype; D015221:Potassium Channels / Q000235:genetics / Q000502:physiology; D011379:Prognosis; D012307:Risk Factors; D015222:Sodium Channels / Q000235:genetics / Q000502:physiology; D013577:Syndrome
chemical_list: D015221:Potassium Channels; D015222:Sodium Channels