title: Sleep, breathing and the nose.
abstract: During sleep there is a discrete fall in minute ventilation and an associated increase in upper airway resistance. In normal subjects, the nasal part of the upper airway contributes only little to the elevation of the total resistance, which is mainly the consequence of pharyngeal narrowing. Yet, swelling of the nasal mucosa due to congestion of the submucosal capacitance vessels may significantly affect nasal airflow. In many healthy subjects an alternating pattern of congestion and decongestion of the nasal passages is observed. Some individuals demonstrate congestion of the ipsilateral half of the nasal cavity when lying down on the side. Nasal diseases, including structural anomalies and various forms of rhinitis, tend to increase nasal resistance, which typically impairs breathing via the nasal route in recumbency and during sleep. A role of nasal obstruction in the pathogenesis of sleep-disordered breathing has been implicated by many authors. While it proves difficult to show a relationship between the degree of nasal obstruction and the number of disturbed breathing events, the presence of nasal obstruction will most likely have an impact on the severity of sleep-disordered breathing. Identification of nasal obstruction is important in the diagnostic work-up of patients suffering from snoring and sleep apnea.
authors.affiliation: Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium. Dirk.pevernagie@ugent.be
authors.forename: Dirk A
authors.initials: DA
authors.lastname: Pevernagie
authors.forename: Micheline M
authors.initials: MM
authors.lastname: De Meyer
authors.forename: Sofie
authors.initials: S
authors.lastname: Claeys
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D006801:Humans; D009296:Nasal Cavity / Q000502:physiology / Q000503:physiopathology; D009297:Nasal Mucosa / Q000502:physiology / Q000503:physiopathology; D015508:Nasal Obstruction / Q000175:diagnosis / Q000503:physiopathology; D009666:Nose / Q000502:physiology*; D011187:Posture / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000503:physiopathology; D012913:Snoring / Q000175:diagnosis / Q000503:physiopathology