title: Interobserver reproducibility of histological features in cutaneous malignant melanoma.
abstract: OBJECTIVE
  To assess the interobserver reproducibility of certain histological features proposed for the diagnosis of melanoma.
  
  
  METHODS
  In a series of melanomas, 13 histological parameters were analysed: dimension > 6 mm, asymmetry, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, cytological atypia, mitoses, dermal lymphocytic infiltrate, and necrosis.
  
  
  RESULTS
  The agreement (reproducibility) between the nine observers was excellent (kappa > 0.75) for 10 of the 13 examined features (dimension > 6 mm, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, mitoses, and necrosis). The agreement for asymmetry was very close to excellence (kappa = 0.74), and that for cytological atypia (kappa = 0.65) and dermal lymphocytic infiltrate (kappa = 0.47) was slightly lower, but in the fair to good agreement range. The kappa values obtained by comparison with the majority diagnosis were generally high (> or = 0.85); the mean value of kappa was lower (0.70) for only one parameter (dermal lymphocytic infiltrate).
  
  
  CONCLUSIONS
  The parameters investigated showed an overall good reproducibility.
authors.affiliation: Dermatopathology Section, S. M. Annunziata Hospital, Health Unit 10 of Florence, I-50011 Antella, Florence, Italy. cylaur@tin.it
authors.forename: C
authors.initials: C
authors.lastname: Urso
authors.forename: F
authors.initials: F
authors.lastname: Rongioletti
authors.forename: D
authors.initials: D
authors.lastname: Innocenzi
authors.forename: C
authors.initials: C
authors.lastname: Saieva
authors.forename: D
authors.initials: D
authors.lastname: Batolo
authors.forename: S
authors.initials: S
authors.lastname: Chimenti
authors.forename: R
authors.initials: R
authors.lastname: Filotico
authors.forename: R
authors.initials: R
authors.lastname: Gianotti
authors.forename: M
authors.initials: M
authors.lastname: Lentini
authors.forename: C
authors.initials: C
authors.lastname: Tomasini
authors.forename: A
authors.initials: A
authors.lastname: Rebora
authors.forename: M
authors.initials: M
authors.lastname: Pippione
mesh_terms: D006801:Humans; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D008938:Mitosis; D009336:Necrosis; D015588:Observer Variation; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D008543:Melanins