Clindamycin in dentistry: more than just effective prophylaxis for endocarditis?
Clindamycin is a broad-spectrum antibiotic with activity against aerobic, anaerobic, and beta-lactamase-producing pathogens. This antibiotic has been used for many years as prophylactic treatment during dental procedures to prevent endocarditis. However, the spectrum and susceptibility of the bacteria species involved in dental infections indicate that clindamycin would also be an effective treatment option for these conditions. In addition to its antiinfective properties, clindamycin has high oral absorption, significant tissue penetration, including penetration into bone, and stimulatory effects on the host immune system. This review discusses the microbiologic and clinical evidence supporting the efficacy and safety of clindamycin for the successful management of dental infections.
Brook
Itzhak
I
Georgetown University School of Medicine, USA.
Lewis
Mike A O
MA
Sándor
George K B
GK
Jeffcoat
Marjorie
M
Samaranayake
L P
LP
Vera Rojas
Jorge
J
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002981:Clindamycin / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use*; D015921:Dental Implants / Q000009:adverse effects; D003788:Dental Pulp Diseases / Q000188:drug therapy / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004697:Endocarditis, Bacterial / Q000517:prevention & control; D005491:Focal Infection, Dental / Q000188:drug therapy* / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D010518:Periodontitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology
D000900:Anti-Bacterial Agents; D015921:Dental Implants; D002981:Clindamycin