Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants.
c-Jun N-terminal kinase (JNK) plays an integral role in neuronal death in multiple cell lines following a wide variety of stimuli and in a number of physiological functions that may be involved in human disease, including CNS diseases. In the past decades, many researchers in this field have found and reinforced the concept that prolonged activation of JNK signalling can induce neuronal cell death by both a transcriptional induction of death-promoting genes and modulation of the mitochondrial apoptosis pathways. Data are emerging to extend the understanding of the JNK signalling and confirm the possibility that targeting JNK signalling may offer an effective therapy for pathological conditions in the near future. This review will focus on the pro-apoptotic role of JNK signalling and updated pharmacological inhibitors of this pathway.
Zhang
Guang-Yi
GY
Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou, Jiangsu, 221002, PR China. gyzhang@xzmc.edu.cn
Zhang
Quan-Guang
QG
D000097:Acetonitriles / Q000494:pharmacology; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D052160:Benzothiazoles; D002227:Carbazoles / Q000494:pharmacology; D006801:Humans; D026121:Indole Alkaloids; D007211:Indoles / Q000494:pharmacology; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction; D013844:Thiazoles / Q000494:pharmacology
C489138:1,3-benzothiazol-2-yl(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile; D000097:Acetonitriles; D000873:Anthracenes; D052160:Benzothiazoles; D002227:Carbazoles; D026121:Indole Alkaloids; D007211:Indoles; D018696:Neuroprotective Agents; D047428:Protein Kinase Inhibitors; D013844:Thiazoles; C106592:3,9-bis((ethylthio)methyl)-K-252a; C432165:pyrazolanthrone; C049985:staurosporine aglycone; D048031:JNK Mitogen-Activated Protein Kinases