4-aminometyl-3-nitrobenzoic acid--a photocleavable linker for oligonucleotides containing combinatorial libraries.
We detail the design, synthesis, and characterization of an o-nitrobenzyl-based photolabile linker containing amine and carboxyl anchor groups. A model nucleoside monomer modified with an imidazole residue and a precursor unit linked to a heterocyclic base through a photolabile tether is constructed Upon UV irradiation (313- 365 nm), the imidazole containing part of this molecule is released.
Abramova
Tatiana V
TV
The Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia. abramova@niboch.nsc.ru
Silnikov
Vladimir N
VN
D062365:Aminobenzoates / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry; D018716:Molecular Mimicry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D010777:Photochemistry / Q000379:methods; D012260:Ribonucleases / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays; D062368:meta-Aminobenzoates
D062365:Aminobenzoates; D007093:Imidazoles; D009841:Oligonucleotides; D062368:meta-Aminobenzoates; C029899:imidazole; D012260:Ribonucleases; C044855:3-aminobenzoic acid