title: Gold nanoparticle decoration of DNA on silicon.
abstract: Electrostatic assembly of cationic nanoparticles onto the negatively charged backbone of double-stranded DNA has been shown to produce one-dimensional chains with potential use as nanoelectronic components. In this paper, micron long DNA templates stretched on aminosilane- and hexamethyldisilazane-modified silicon surfaces are used to assemble 3.5 nm gold nanoparticles passivated with cationic thiocholine. Atomic force microscopy is used to analyze the density and defects along the approximately 5 nm high structures, with comparison between positively charged and neutral surfaces. Low background adsorption of nanoparticles is facilitated by both these surface chemistries, while the neutral surface yields a more densely packed assembly.
authors.affiliation: Department of Chemistry and Biochemistry, Biomolecular Science and Engineering Program, University of California, Santa Barbara, 93106-9510, USA.
authors.forename: Gary
authors.initials: G
authors.lastname: Braun
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Inagaki
authors.forename: R August
authors.initials: RA
authors.lastname: Estabrook
authors.forename: D K
authors.initials: DK
authors.lastname: Wood
authors.forename: Eran
authors.initials: E
authors.lastname: Levy
authors.forename: A N
authors.initials: AN
authors.lastname: Cleland
authors.forename: Geoffrey F
authors.initials: GF
authors.lastname: Strouse
authors.forename: Norbert O
authors.initials: NO
authors.lastname: Reich
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles; D018625:Microscopy, Atomic Force; D012825:Silicon / Q000737:chemistry*
chemical_list: D006046:Gold; D004247:DNA; D012825:Silicon