Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy.
We report a patient with gastric small cell carcinoma (SCC) who showed a marked response to neoadjuvant chemotherapy. The patient was a 72-year-old Japanese man who was admitted because of epigastralgia. Subsequent examination revealed the presence of advanced gastric carcinoma in the lesser curvature of the lower body of the stomach, with multiple abdominal lymph node metastases. Endoscopic biopsy specimens from the tumor revealed SCC with moderately differentiated adenocarcinoma. The patient received neoadjuvant chemotherapy consisting of carboplatin (400 mg/m2, for 1 day), epirubicin (27 mg/m2, for 1 day), etoposide (70 mg/m2, for 3 days), and 5-fluorouracil (330 mg/m2, for 11 days). Clinically, the primary tumor and lymph node metastases were markedly reduced. Subsequently the patient underwent curative surgery and was alive without recurrence for more than 3 years after the surgery.
Nakamura
Yasuhiro
Y
Department of Pathology, Tohoku Graduate University School of Medicine, 2-1 Seiryo-machi, Sendai 980-8575, Japan. nakamura@patholo2.med.tohoku.ac.jp
Otani
Setsuya
S
Otaka
Michiro
M
Shimada
Tomoyuki
T
Takahashi
Satsuki
S
Saito
Masahiro
M
Takahashi
Tohru
T
Komatsu
Masahumi
M
Suzuki
Toshie
T
Okubo
Shunji
S
Hayashi
Masato
M
Sasano
Hironobu
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery