Possible role of calcitonin gene-related peptide in osmoregulation via the endocrine control of the gill in a teleost, the eel, Anguilla anguilla.
Osmoregulation is a major challenge in aquatic animals involving a complex endocrine control. We investigated the potential role of calcitonin gene-related peptide (CGRP, a neuromediator in mammals) in the endocrine control of the gill in a teleost, the eel. Transfer from freshwater to seawater induced an hyperosmolality and a concomitant large increase in plasma CGRP levels. Specific CGRP binding sites were characterized in the gill and their number was up-regulated after seawater transfer. This study suggests that the endocrine control of gill function during osmoregulation may represent an ancient role of CGRP in vertebrates.
Lafont
Anne-Gaëlle
AG
Muséum National d'Histoire Naturelle, Département des Milieux et Peuplements Aquatiques, USM 0401, UMR 5178, Biologie des Organismes Marins et Ecosystèmes, Station de Biologie Marine, 29900 Concarneau, France. anne-gaelle.lafont@wanadoo.fr
Fitzpatrick
Thomas
T
Cliff Rankin
J
J
Dufour
Sylvie
S
Fouchereau-Peron
Martine
M
D000811:Anguilla / Q000378:metabolism*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D005618:Fresh Water; D005880:Gills / Q000378:metabolism*; D010949:Plasma / Q000737:chemistry; D012623:Seawater; D014882:Water-Electrolyte Balance / Q000502:physiology*
D015740:Calcitonin Gene-Related Peptide