Atherosclerosis and cancer: flip sides of the neoplastic response in mammalian cells?
Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer--pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentiation and share many common genomic targets during the course of growth dysregulation. Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin.
Ramos
Kenneth S
KS
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40292, USA. ksramos01@gwise.louisville.edu
Partridge
Charles R
CR
D000818:Animals; D050197:Atherosclerosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D002273:Carcinogens / Q000633:toxicity; D002468:Cell Physiological Phenomena; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology*
D002273:Carcinogens