Synthesis of selenium-containing polyphenolic acid esters and evaluation of their effects on antioxidation and 5-lipoxygenase inhibition.
Six novel selenium-containing polyphenolic acid esters were synthesized and evaluated as antioxidants and 5-lipoxygenase inhibitors. Synthesis of the title compounds involved the Mitsunobu reaction of polyphenolic acids with 2-phenylselenoethanol. Compounds and were found to be very effective antioxidants and 5-lipoxygenase inhibitors with activity comparable to or better than caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE).
Lin
Chi-Fu
CF
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Chang
Tsu-Chung
TC
Chiang
Chih-Chia
CC
Tsai
Hou-Jen
HJ
Hsu
Ling-Yih
LY
D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D030421:Peroxynitrous Acid / Q000737:chemistry; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D010851:Picrates / Q000737:chemistry; D059808:Polyphenols; D018036:Selenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D000975:Antioxidants; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D005419:Flavonoids; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors; D010636:Phenols; D010851:Picrates; D059808:Polyphenols; D018036:Selenium Compounds; D030421:Peroxynitrous Acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C040048:caffeic acid