title: [Role of interleukin-1 receptor antagonist in protecting kidney from injury induced by asphyxia in neonatal rats].
abstract: OBJECTIVE
  To observe the role of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in protecting kidney from injury induced by asphyxia in neonatal rats.
  
  
  METHODS
  Neonatal rats were used as experimental animals. The changes in intrarenal inflammatory response and renal injury were examined in the control group (n=13), and 2, 24 and 48 hours after asphyxia followed by normal saline treatment in those treated with rhIL-1ra.
  
  
  RESULTS
  In normal saline group, the white blood cell count, the blood interleukin-1 (IL-1), IL-8, IL-6, nitric oxide (NO), endothelin (ET-1) levels, and the renal coefficient (LRC), the scores of injured tubules of the left kidney were significantly increased at 2 hours (n=10), 24 hours (n=11), and 48 hours (n=10, P<0.05 or P<0.01). Compared with the normal saline group, the levels of the above parameters, except IL-6, were significantly decreased in rhIL-1ra treatment group at the same time points (P<0.05 or P<0.01). Serum IL-6 at 24 hours and 48 hours was also decreased in rhIL-1ra treatment group significantly (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  The results suggest that rhIL-1ra may protect renal injury after asphyxia via inhibiting intrarenal inflammatory response.
authors.affiliation: Department of Pediatrics, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan, China.
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Dong
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Chen
authors.forename: Shu-qin
authors.initials: SQ
authors.lastname: Chen
authors.forename: Han-an
authors.initials: HA
authors.lastname: Long
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Xue-song
authors.initials: XS
authors.lastname: Qu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zou
authors.forename: Zhang-hua
authors.initials: ZH
authors.lastname: Tang
authors.forename: Cun-liang
authors.initials: CL
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Hua
mesh_terms: D000818:Animals; D001237:Asphyxia / Q000188:drug therapy / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D053590:Interleukin 1 Receptor Antagonist Protein / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein