title: Acute myocardial infarction in a young woman with antiphospholipid syndrome and occasional cocaine abuse.
abstract: We describe a case of acute myocardial infarction in a 19-year-old woman reporting a history of occasional cocaine abuse with last exposure 4 days before symptom onset, otherwise at low cardiovascular risk. Coronary angiography showed thrombotic occlusion of anterior descending coronary artery without atherosclerotic plaques, and complete recanalization of the vessel after anticoagulation with enoxaparine. Hypercoagulability evaluation revealed the presence of antiphospholipid antibodies. We suppose that cocaine abuse may have had a delayed effect as trigger of acute myocardial infarction. This action may be due to cocaine-induced endothelial activation and to a synergic prothrombotic activity of cocaine and antiphospholipid antibodies.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Raddino
authors.forename: Claudio
authors.initials: C
authors.lastname: Pedrinazzi
authors.forename: Gregoriana
authors.initials: G
authors.lastname: Zanini
authors.forename: Roberto
authors.initials: R
authors.lastname: Procopio
authors.forename: Livio
authors.initials: L
authors.lastname: Dei Cas
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D019970:Cocaine-Related Disorders / Q000150:complications*; D017023:Coronary Angiography; D017984:Enoxaparin / Q000627:therapeutic use; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D015912:Thrombolytic Therapy / Q000379:methods
chemical_list: D017152:Antibodies, Antiphospholipid; D017984:Enoxaparin; D005343:Fibrinolytic Agents