Cytotoxic phenolic constituents from the root of Actinidia chinensis.
Twelve phenolic compounds, including four novel skeleton phenolic compounds, planchols A-D (1-4), together with four pairs of isomeric flavanoids (5-12) were isolated from the root of Actinidia chinensis Planch (Actinidiaceae). Their structures were elucidated by spectroscopic analysis and chemical evidence. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it was found that 1 and 2 showed remarkable cytotoxic activity against P-388 and A-549 cell lines.
Chang
Jun
J
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China [corrected] jch1@uic.edu
Case
Ryan
R
D029042:Actinidia; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D010636:Phenols / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts