title: Differential brain activation according to chronic social reward frustration.
abstract: Neural correlates of reward frustration are increasingly studied in humans. In line with prediction error theory, omission of an expected reward is associated with relative decreases of cerebral activation in dopaminergic brain areas. We investigated whether a history of chronic work-related reward frustration influences this reward-dependent activation pattern by means of functional magnetic resonance imaging. Solving arithmetic tasks was followed by either monetary reward or omission of reward. Hyperactivations in the medial prefrontal, anterior cingulate and dorsolateral prefrontal cortex were observed in a group of healthy adults with high susceptibility to reward frustration as compared with a group with low susceptibility. Findings indicate a compromised ability of adapting brain activation among those suffering form chronic social reward frustration.
authors.affiliation: Department of Medical Sociology, University of Duesseldorf, Duesseldorf, Germany. seigrist@uni-duesseldorf.de
authors.forename: Johannes
authors.initials: J
authors.lastname: Siegrist
authors.forename: Ingo
authors.initials: I
authors.lastname: Menrath
authors.forename: Tony
authors.initials: T
authors.lastname: Stöcker
authors.forename: Martina
authors.initials: M
authors.lastname: Klein
authors.forename: Thilo
authors.initials: T
authors.lastname: Kellermann
authors.forename: N Jon
authors.initials: NJ
authors.lastname: Shah
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.forename: Frank
authors.initials: F
authors.lastname: Schneider
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002908:Chronic Disease; D004298:Dopamine / Q000502:physiology; D005639:Frustration; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012201:Reward; D012919:Social Behavior; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D004298:Dopamine