4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.
Narender
Tadigoppula
T
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India. tnarender@rediffmail.com
Puri
Anju
A
Shweta
Khaliq
Tanvir
T
Saxena
Rashmi
R
Bhatia
Geetika
G
Chandra
Ramesh
R
D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D006224:Cricetinae; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D007532:Isoleucine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D008297:Male; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D029910:Trigonella / Q000737:chemistry
C104672:4-hydroxyisoleucine; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005227:Fatty Acids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D014280:Triglycerides; D007532:Isoleucine; D002784:Cholesterol