title: New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta.
abstract: Two novel phenanthrene derivatives, aristololactam IVa (1) and 9-hydroxy aristolochic acid I (2) were isolated from the stem and leaves of Anstolochia contorta Bunge, together with 17 known compounds (3-19). The structures of these compounds were determined by spectroscopic analysis. The phenanthrenes obtained were tested for cytotoxicity against renal proximal tubular epithelial cell line (HK-2). Aristololactam IVa and 7-methoxy aristololactam IV were found to have strong cytotoxic activity against HK-2 cells with a potency similar to or even stronger than those of aristolochic acid I and aristololactam I.
authors.affiliation: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Su
authors.forename: C M
authors.initials: CM
authors.lastname: Ma
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wen
authors.forename: M Y
authors.initials: MY
authors.lastname: Shang
authors.forename: X M
authors.initials: XM
authors.lastname: Li
authors.forename: G X
authors.initials: GX
authors.lastname: Liu
authors.forename: S Q
authors.initials: SQ
authors.lastname: Cai
mesh_terms: D030022:Aristolochia / Q000737:chemistry*; D034341:Aristolochic Acids / Q000737:chemistry* / Q000302:isolation & purification; D002460:Cell Line; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C505883:9-hydroxy aristolochic acid I; D034341:Aristolochic Acids; D010616:Phenanthrenes; C505882:aristololactam IVa; C000228:aristolochic acid I