[Optimization of artificial inseminations with donor semen: a four-year experience].
OBJECTIVE
Our aim was to analyse the results of a donor insemination program using ovarian stimulation, swim-up sperm preparation and intrauterine insemination proposed to women with a maximum age of 39. Incidence of several clinical and biological parameters on success rates was investigated.


METHODS
Retrospective analysis of the results of 249 cycles performed in 106 couples during a four-year period is reported.


RESULTS
Overall pregnancy rate of 28.1% and delivery rate of 22% per cycle were achieved, with a multiple pregnancy rate of 11.4%. Most of the pregnancies (84%) were obtained before the fourth insemination. Among the different parameters studied the total number of motile sperm inseminated was found to be the most important factor for success rate: pregnancy rate per cycle reached 40.4% if more than 1.5 million progressive sperm were inseminated vs. 24.7% if they were less than 1.5 million (P<0.05).


CONCLUSIONS
In precise conditions, outcome of inseminations with donor semen can reach satisfying pregnancy rates, being a valuable help for couples suffering of long-time infertility.
Achard
V
V
Centre d'assistance médicale à la procréation (AMP), CHU la Conception, 147, boulevard Baille, 13005 Marseille, France. vincent.achard@mail.ap-hm.fr
Perrin
J
J
Saias-Magnan
J
J
Noizet
A
A
Grillo
J-M
JM
Paulmyer-Lacroix
O
O
D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D008297:Male; D011247:Pregnancy; D013076:Sperm Count; D013081:Sperm Motility; D016896:Treatment Outcome