title: Host receptors in malaria merozoite invasion.
abstract: The clinical manifestations of Plasmodium falciparum malaria are directly linked to the blood stage of the parasite life cycle. At the blood stage, the circulating merozoites invade erythrocytes via a specific invasion pathway often identified with its dependence or independence on sialic acid residues of the host receptor. The invasion process involves multiple receptor-ligand interactions that mediate a complex series of events in a period of approximately 1 min. Although the mechanism by which merozoites invade erythrocytes is not fully understood, recent advances have put a new perspective on the importance of developing a multivalent blood stage-malaria vaccine. In this review, we highlight the role of currently identified host invasion receptors in blood-stage malaria.
authors.affiliation: Division of Cell Biology, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Oh
authors.forename: A H
authors.initials: AH
authors.lastname: Chishti
mesh_terms: D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000502:physiology; D004375:Duffy Blood-Group System / Q000502:physiology; D004912:Erythrocytes / Q000469:parasitology*; D006021:Glycophorins / Q000502:physiology; D006790:Host-Parasite Interactions; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology*; D010961:Plasmodium / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology
chemical_list: C473745:ACKR1 protein, human; D001457:Anion Exchange Protein 1, Erythrocyte; D004375:Duffy Blood-Group System; D006021:Glycophorins; D011956:Receptors, Cell Surface