title: Parkinson's disease in diphenyl-exposed workers--a causal association?
abstract: We report a cluster of five cases of Parkinson's disease (PD) among paper mill workers exposed to a fungicide, diphenyl. The cause of PD is still unknown, but epidemiological studies have indicated an elevated risk of developing PD after exposure to pesticides. The five cases of PD were found in a group of 255 diphenyl-exposed workers, and the number of expected cases in the exposed group was estimated to be 0.9, resulting in a relative risk of 5.6 (95% CI 1.8-13). Exposure to diphenyl may have contributed to this PD cluster, but chance is an alternative explanation.
authors.affiliation: Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, University of Goteborg, SE-412 66 Goteborg, Sweden. gunilla.wastensson@amm.gu.se
authors.forename: Gunilla
authors.initials: G
authors.lastname: Wastensson
authors.forename: Stig
authors.initials: S
authors.lastname: Hagberg
authors.forename: Eva
authors.initials: E
authors.lastname: Andersson
authors.forename: Bo
authors.initials: B
authors.lastname: Johnels
authors.forename: Lars
authors.initials: L
authors.lastname: Barregård
mesh_terms: D000328:Adult; D000368:Aged; D001713:Biphenyl Compounds / Q000009:adverse effects*; D015331:Cohort Studies; D005602:France / Q000453:epidemiology; D005659:Fungicides, Industrial / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data*; D010300:Parkinson Disease / Q000453:epidemiology* / Q000209:etiology*; D015203:Reproducibility of Results
chemical_list: D001713:Biphenyl Compounds; D005659:Fungicides, Industrial; C010574:biphenyl