title: syn-selective direct catalytic asymmetric Mannich-type reactions of hydroxyketones using Y{N(SiMe3)2}3/linked-BINOL complexes.
abstract: [reaction, structure: see text] Chiral Y{N(SiMe3)2}3/linked-BINOL catalyst generated Y-enolate in situ from various hydroxyketones (R2 = aryl, heteroaryl). Beta-amino-alpha-hydroxy ketones (R1 = aryl, heteroaryl, alkenyl) were obtained syn-selectively (up to 96/4) in high ee (up to 98%) and good yield (up to 98% yield).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Sugita
authors.forename: Akitake
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yamagiwa
authors.forename: Shinya
authors.initials: S
authors.lastname: Handa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki