title: Structural brain correlates of unconstrained motor activity in people with schizophrenia.
abstract: Avolition affects quality of life in chronic schizophrenia. We investigated the relationship between unconstrained motor activity and the volume of key executive brain regions in 16 male patients with schizophrenia. Wristworn actigraphy monitors were used to record motor activity over a 20 h period. Structural magnetic resonance imaging brain scans were parcellated and individual volumes for anterior cingulate cortex and dorsolateral prefrontal cortex extracted. Patients'total activity was positively correlated with volume of left anterior cingulate cortex. These data suggest that the volume of specific executive structures may affect (quantifiable) motor behaviours, having further implications for models of the 'will' and avolition.
authors.affiliation: Sheffield Cognition and Neuroimaging Laboratory (SCANLab), Department of Academic Clinical Psychiatry, University of Sheffield,The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT,UK. t.f.farrow@sheffield.ac.uk
authors.forename: Tom F D
authors.initials: TF
authors.lastname: Farrow
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hunter
authors.forename: Iain D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: Russell D J
authors.initials: RD
authors.lastname: Green
authors.forename: Sean A
authors.initials: SA
authors.lastname: Spence
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D002908:Chronic Disease; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000379:methods; D009043:Motor Activity; D017397:Prefrontal Cortex / Q000473:pathology; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology