Glucocorticoid pathways in chronic obstructive pulmonary disease therapy.
Lung function measures in patients with chronic obstructive pulmonary disease remain insensitive to corticosteroid actions, in contrast to the clinical improvements observed in most patients with asthma. By uncovering the reason for this paradox, physicians should be able to implement treatment regimens that restore corticosteroid sensitivity. Corticosteroids exert their effects by binding to a cytoplasmic glucocorticoid receptor, which is subjected to post-translational modification by phosphorylation. Receptor phosphorylation may influence hormone binding and nuclear translocation, as well as alter other glucocorticoid receptor interactions, its protein half-life, and downregulation processes. This suggests that a "phosphorylation code" may exist for glucocorticoid receptor function. Oxidative stress due to cigarette smoke may also be a mechanism for the corticosteroid resistance observed in chronic obstructive pulmonary disease, as it enhances proinflammatory transcription. Reduced glucocorticoid nuclear translocation along with attenuated histone deacetylase activity may be partially responsible for this effect. Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease.
Adcock
Ian M
IM
Cell and Molecular Biology, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK. ian.adcock@imperial.ac.uk
Ito
Kazuhiro
K
D000280:Administration, Inhalation; D001980:Bronchi / Q000473:pathology; D004351:Drug Resistance; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D018384:Oxidative Stress; D010766:Phosphorylation; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012097:Repressor Proteins / Q000378:metabolism; D014158:Transcription, Genetic
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D012097:Repressor Proteins; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases