Helicases that interact with replication forks: new candidates from archaea.
Overcoming DNA replication fork blocks is essential for completing genome duplication and cell division. Archaea and eukaryotes drive replication using essentially the same protein machinery. Archaea may be a valuable resource for identifying new helicase components at advancing forks and/or in replication-restart pathways. As described here, these may be relevant to understanding genome instability in metazoans.
Bolt
E L
EL
Institute of Genetics, School of Biology, Queen's Medical Centre, University of Nottingham, Nottingham NG 72UH, UK. ed.bolt@nottingham.ac.uk
D001105:Archaea / Q000201:enzymology*; D019843:Archaeal Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D009690:Nucleic Acid Conformation; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D019843:Archaeal Proteins; D004265:DNA Helicases