A model of anxious depression: persistence of behavioral pathology.
Chronic psychoemotional stress induced by negative experience of social defeats in intermale confrontations over a period of 30 days was found to lead to the development of anxious-depressive symptomatology in male mice. Cessation of the psychopathogenic conditions and placing of depressed animals in comfortable conditions for 1-2 weeks with females did not lift the pathological state. Individuals continued to show marked anxiety, a behavioral deficit, decreased communicativeness, and a high level of depressivity, as revealed by a variety of behavioral tests. Persistence of the resulting psychoemotional disturbance in these animals is evidence for the development and persistence of the behavioral pathology requiring drug treatment.
Avgustinovich
D F
DF
Neurogenetics of Social Behavior Laboratory, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia.
Kovalenko
I L
IL
Kudryavtseva
N N
NN
D000704:Analysis of Variance; D000819:Animal Communication; D000818:Animals; D001008:Anxiety Disorders / Q000503:physiopathology* / Q000523:psychology*; D001522:Behavior, Animal; D003220:Conflict, Psychological; D003863:Depression / Q000503:physiopathology* / Q000523:psychology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009068:Movement / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D018709:Statistics, Nonparametric