title: Influence of HIV infection on changes in circulating leukocyte counts during measles in Zambian children.
abstract: Measles remains an important problem in Africa, where human immunodeficiency virus type 1 (HIV-1) infection is prevalent. To identify the consequences of coinfection, Zambian children hospitalized with measles were studied at entry, discharge, and 1 month after discharge. All children had low lymphocyte and eosinophil counts at entry and high leukocyte and monocyte counts during recovery. The death of cultured lymphocytes was more prolonged for HIV-positive children. CD38 and Fas were increased on CD4+ and CD8+ lymphocytes, and CD28 was decreased on CD8+ lymphocytes in all children. Abnormalities in CD4+ and CD8+ lymphocyte percentages and CD28 expression associated with HIV infection were preserved during measles. Therefore, the patterns of changes in leukocyte counts were similar, with little evidence that measles exacerbated HIV-associated lymphocyte abnormalities.
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
authors.forename: Judith J
authors.initials: JJ
authors.lastname: Ryon
authors.forename: William J
authors.initials: WJ
authors.lastname: Moss
authors.forename: Mwaka
authors.initials: M
authors.lastname: Monze
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Quinn
authors.forename: Diane E
authors.initials: DE
authors.lastname: Griffin
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000378:metabolism; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male; D008457:Measles / Q000150:complications* / Q000276:immunology*; D015024:Zambia
chemical_list: D015703:Antigens, CD