title: Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase.
authors.affiliation: Department of Chemistry, Box H, Brown University, Providence, RI 02912-9108, USA.
authors.forename: Jiaquan
authors.initials: J
authors.lastname: Wu
authors.forename: Weiguo
authors.initials: W
authors.lastname: He
authors.forename: Chaitan
authors.initials: C
authors.lastname: Khosla
authors.forename: David E
authors.initials: DE
authors.lastname: Cane
mesh_terms: D018360:Crystallography, X-Ray; D006868:Hydrolysis; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D048630:Polyketide Synthases / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C008517:methymycin; D048630:Polyketide Synthases; C003145:picromycin