title: The use of phase inversion temperature (PIT) microemulsion technology to enhance oil utilisation during Streptomyces rimosus fed-batch fermentations to produce oxytetracycline.
abstract: The use of a rapeseed oil emulsion feed, produced by a phase inversion temperature (PIT) process, produced more biomass, gave a 3-fold increase in oil utilisation and a higher oxytetracycline titre but a higher residual oil concentration when compared to a conventional fed-batch Streptomyces rimosus process fed with crude rapeseed oil. Importantly, microbial utilisation of the surfactant was confirmed for the first time.
authors.affiliation: Biochemical Engineering, Department of Chemical Engineering, The University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK.
authors.forename: Panos A
authors.initials: PA
authors.lastname: Papapanagiotou
authors.forename: Henry
authors.initials: H
authors.lastname: Quinn
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Molitor
authors.forename: Alvin W
authors.initials: AW
authors.lastname: Nienow
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hewitt
mesh_terms: D019149:Bioreactors; D003470:Culture Media; D004655:Emulsions; D007218:Industrial Microbiology / Q000379:methods; D009821:Oils / Q000378:metabolism*; D010118:Oxytetracycline / Q000096:biosynthesis*; D013302:Streptomyces / Q000254:growth & development*; D013696:Temperature
chemical_list: D003470:Culture Media; D004655:Emulsions; D009821:Oils; D010118:Oxytetracycline