Effect of an adzuki bean extract on hepatic anti-oxidant enzyme mRNAs in D-galactosamine-treated rats.
In acute hepatic injury tests, an adzuki bean extract decreased D-galactosamine (GalN)-induced alterations in the serum alanine aminotransferase and aspartate aminotranferase activities to about 37% and 25%, respectively, although there were no significant differences in these activities between the GalN-treated group with the adzuki bean extract and the GalN-treated group without the adzuki bean extract. Furthermore, the hepatic glutathione peroxidase, glutathione reductase, and Mn- and Cu,Zn-superoxide dismutase mRNA levels in the GalN-treated group with the adzuki bean extract were higher than those in the control group and GalN-treated group without the adzuki bean extract.
Ohba
Kiyoshi
K
Hokkaido Tokachi Area Regional Food Processing Technology Center, Obihiro, Japan.
Nirei
Megumi
M
Watanabe
Shoko
S
Han
Kyu-Ho
KH
Hashimoto
Naoto
N
Shimada
Ken-Ichiro
K
Sekikawa
Mitsuo
M
Chiji
Hideyuki
H
Fukushima
Michihiro
M
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D007887:Fabaceae; D005688:Galactosamine / Q000008:administration & dosage / Q000009:adverse effects; D005979:Glutathione Peroxidase / Q000235:genetics; D005980:Glutathione Reductase / Q000235:genetics; D008099:Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000187:drug effects / Q000235:genetics*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012333:RNA, Messenger / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000235:genetics
D010936:Plant Extracts; D012333:RNA, Messenger; D005688:Galactosamine; D010088:Oxidoreductases; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase