title: The rational design of vaccines.
abstract: This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host-pathogen interactions. The key question addressed here is, with all our research and understanding, have we reached a new echelon in vaccine development, that of rational design?
authors.affiliation: Medicines Research Unit, School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
authors.forename: Vincent W
authors.initials: VW
authors.lastname: Bramwell
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Perrie
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods; D015195:Drug Design; D006801:Humans; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D014612:Vaccines