Commentary on: 'old and new data, new issues: the mitochondrial Deltapsi' by H. Tedeschi.
A recent review [H.Tedeschi, Old and New Data, New Issues: the Mitochondrial Deltapsi, Biochim. Biophys. Acta, Bioenerg. (2005)] has questioned the validity of experiments performed more than 30 years ago that provided the first quantitative estimates of the protonmotive force generated by mitochondria. This commentary explains that the review author's confusion stems from ignoring the data in these papers on the trans-membrane pH gradient.
Nicholls
David G
DG
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. dnicholls@buckinstitute.org
D000818:Animals; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D018892:Proton-Motive Force; D051381:Rats; D015203:Reproducibility of Results