The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism.
Inflammatory processes are made up of a multitude of complex cascades. Under physiological conditions these processes aid in tissue repair. However, under pathophysiological environments, such as wound healing and hypoxia-ischaemia (HI), inflammatory mediators become imbalanced, resulting in tissue destruction. This review addresses the changes in reactive oxygen species (ROS), L-arginine and arachidonic acid metabolism in wound healing and HI and subsequent treatments with promising anti-oxidants. Even though these models may appear divergent, anti-oxidant treatments are nevertheless still having favourable effects. On the basis of recent findings, it is apparent that protection with anti-oxidants is not solely attributed to scavenging of ROS. In addition, the actions of anti-oxidants must be considered in light of the inflammatory process being assessed. To this end, there does not appear to be any universally applicable single mechanism to explain the actions of anti-oxidants.
Kapoor
M
M
Department of Pharmacology and Toxicology, University of Otago, Dunedin, P.O. Box 913, New Zealand.
Clarkson
A N
AN
Sutherland
B A
BA
Appleton
I
I
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000502:physiology / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D000975:Antioxidants; D017382:Reactive Oxygen Species; D016718:Arachidonic Acid; D001120:Arginine