title: Mild, efficient, selective and "green" benzoylation of nucleosides using benzoyl cyanide in ionic liquid.
abstract: Use of benzoyl cyanide (BzCN) for benzoylation of nucleosides has been studied, both in pyridine and in ionic liquid BzCN in 1-methoxyethyl-3-methylimidazolium methanesulfonate as ionic liquid has been found to be a "green "alternative compared to the pyridine-BzCN system. An efficient and selective benzoylation of nucleosides of both, the 2'-deoxy- and the ribo-series at ambient temperature was accomplished.
authors.affiliation: Rasayan Inc., 2802 Crystal Ridge Road, Encinitas, CA 92008, USA.
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Prasad
authors.forename: Vineet
authors.initials: V
authors.lastname: Kumar
authors.forename: Jyotirmoy
authors.initials: J
authors.lastname: Maity
authors.forename: Yogesh S
authors.initials: YS
authors.lastname: Sanghvi
authors.forename: Vasulinga T
authors.initials: VT
authors.lastname: Ravikumar
authors.forename: Virinder S
authors.initials: VS
authors.lastname: Parmar
mesh_terms: D003486:Cyanides / Q000737:chemistry*; D015195:Drug Design; D007477:Ions; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D012997:Solvents; D013696:Temperature; D013997:Time Factors
chemical_list: D003486:Cyanides; D007477:Ions; D009705:Nucleosides; D009711:Nucleotides; D011725:Pyridines; D012997:Solvents