title: New and one pot chemoselective synthesis of nucleoside 5'-H-phosphonate diesters.
abstract: Arbuzov reaction of phenyl phosphorodichloridite with two equiv of alcohol, or mixture of one equiv of alcohol and one equiv of tert-butyl alcohol led to the corresponding aryl H-phosphonate diesters. Following displacement of the H-phosphonate diesters with unprotected nucleosides chemoselectively produced nucleoside 5-H-phosphonate diesters in good yields, respectively.
authors.affiliation: Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D001671:Biochemistry / Q000379:methods*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry*; D010766:Phosphorylation
chemical_list: D004952:Esters; D009705:Nucleosides; D063065:Organophosphonates