Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.
OBJECTIVE
To compare the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.


METHODS
Fifteen patients with fibromyalgia participated in this randomized, double-blind crossover study composed of two trials separated by a 2-week washout phase. The pharmacy randomly assigned patients to two groups: (a) placebo (glucose) in the morning and 25 mg amitriptyline at bedtime or (b) 20 mg fluoxetine in the morning and placebo at bedtime. The VO(2max) and Wingate anaerobic test were evaluated. Within 24 h after 15-day medication, the tests were repeated.


RESULTS
Peak power and fatigue index increased, and VO(2max) and VT did not change with both fluoxetine and amitriptyline. Mean power significantly increased after fluoxetine but not after amitriptyline.


CONCLUSIONS
Both amitriptyline administration and fluoxetine administration in patients with fibromyalgia have beneficial effects on anaerobic performance. These effects may be important in life quality of the female patients with fibromyalgia.
Ozerbil
Onder
O
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Selcuk University, Meram, Konya, Turkey. ozerbil@yahoo.com
Okudan
Nilsel
N
Gökbel
Hakki
H
Levendoğlu
Funda
F
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects*; D005221:Fatigue / Q000517:prevention & control; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy*; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged
D000928:Antidepressive Agents; D005473:Fluoxetine; D000639:Amitriptyline