Impact of mass distribution of azithromycin on the antibiotic susceptibilities of ocular Chlamydia trachomatis.
In a community of Tanzania where trachoma is endemic, we cultured conjunctival swabs from all residents who had active trachoma and were PCR positive for ocular Chlamydia trachomatis, both before (43 isolates) and 2 months after (9 isolates) mass antibiotic treatment. No clinically or programmatically significant increase in azithromycin or tetracycline resistance was observed.
Solomon
Anthony W
AW
Clinical Research Unit, London School of Hygiene & Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. anthony.solomon@lshtm.ac.uk
Mohammed
Zeena
Z
Massae
Patrick A
PA
Shao
John F
JF
Foster
Allen
A
Mabey
David C W
DC
Peeling
Rosanna W
RW
D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D002692:Chlamydia trachomatis / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D005123:Eye / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014141:Trachoma / Q000188:drug therapy*
D017963:Azithromycin