title: Effects of a low sodium diet on bone metabolism.
abstract: Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodium (2-g/day) diet on bone. Forty postmenopausal African-American and Caucasian women were enrolled in a 2-g/day sodium diet for 6 months. Sodium and calcium excretion, bone turnover, and calcitropic hormones (intact parathyroid hormone (PTH) and 1,25 dihydroxyvitamin D) were measured before and 6 months after the intervention. In women who had baseline sodium excretions equal to or greater than the average sodium intake in the United States (> or =3.4 g/day), the low sodium diet resulted in significant decreases in sodium excretion (P = 0.01), in calcium excretion (P = 0.01), and in a biomarker of bone turnover, aminoterminal propeptide of type I collagen (P = 0.04). However, there were no significant changes in calcitropic hormones, including intact PTH (P = 0.97) or 1,25 dihydroxyvitamin D (P = 0.49) with the low sodium diet. These findings suggest that in postmenopausal women with sodium intakes > or =3.4 g/day, a low sodium diet may have benefits for skeletal health.
authors.affiliation: Department of Medicine, University of Tennessee Health Science Center, 956 Court Avenue, Room G326 Coleman Building, Memphis, TN, 38163, USA. lcarbone@utmem.edu
authors.forename: Laura D
authors.initials: LD
authors.lastname: Carbone
authors.forename: Karen D
authors.initials: KD
authors.lastname: Barrow
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Bush
authors.forename: M David
authors.initials: MD
authors.lastname: Boatright
authors.forename: Jean A
authors.initials: JA
authors.lastname: Michelson
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Pitts
authors.forename: Victorina N
authors.initials: VN
authors.lastname: Pintea
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kang
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Watsky
mesh_terms: D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000652:urine; D003094:Collagen / Q000652:urine; D024042:Collagen Type I / Q000032:analysis; D003404:Creatinine / Q000652:urine; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010455:Peptides / Q000652:urine; D011347:Procollagen / Q000032:analysis; D012964:Sodium / Q000652:urine; D044465:White People
chemical_list: D024042:Collagen Type I; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen; D012964:Sodium; D003404:Creatinine; D002118:Calcium