Changes in body composition and insulin sensitivity in severely obese subjects after laparoscopic adjustable silicone gastric banding (LASGB).
BACKGROUND
Laparoscopic adjustable silicone gastric banding (LASGB) is a viable therapeutic approach to achieve stable body weight reduction in severe obesity. The aim of this study was to evaluate body composition and metabolic features in morbidly obese patients before and after LASGB.


METHODS
There were 15 severely obese patients (Ob) (M/F: 4/11; mean age: 32.5 +/- 3.8 years) and 16 age-and sex-matched healthy lean controls (C) (M/F: 4/12; mean age: 39.5 +/- 2 years). Body mass index (BMI), waist circumference, waist-to-hip ratio, blood pressure, lipid profile, serum glucose and insulin during OGTT, and HOMA-IR were evaluated in all subjects. Body composition and fat distribution were measured using dual energy X-ray absorptiometry (DEXA). Patients were assessed before and six months after LASGB.


RESULTS
The obese subjects showed several metabolic alterations. There were also positive correlations between waist, fat mass (FM), and HOMA-IR at baseline. After LASGB, mean BMI fell from 42.2 kg/m2 to 33.2 kg/m2; waist circumference and abdominal FM% decreased significantly. FM% declined, whereas FFM% increased. The ratio of FM loss to FFM loss was 3.7:1. Serum glucose and insulin levels during OGTT diminished slightly after weight loss and triglyceride levels fell dramatically. After LASGB, fasting insulin and HOMA-IR declined.


RESULTS
LASGB induced a significant improvement in insulin sensitivity and a redistribution of body composition with a relative increase of FFM.
Garrapa
Gabriella G M
GG
Division of Endocrinology, Polytechnic University of Marche, Ancona, Italy.
Canibus
Paola
P
Gatti
Cristina
C
Santangelo
Milena
M
Frezza
Frederica
F
Feliciotti
Francesco
F
Boscaro
Marco
M
Faloia
Emanuela
E
D015502:Absorptiometry, Photon; D000328:Adult; D000886:Anthropometry; D001823:Body Composition; D005260:Female; D015391:Gastroplasty / Q000379:methods*; D006801:Humans; D007333:Insulin Resistance; D010535:Laparoscopy; D008297:Male; D009767:Obesity, Morbid / Q000378:metabolism / Q000628:therapy*; D012828:Silicones; D013270:Stomach / Q000601:surgery*; D015431:Weight Loss
D012828:Silicones