title: [Histological study of livers from the patients with chronic hepatitis B treated with bicyclol].
abstract: OBJECTIVE
  To study histological changes of the livers in patients with chronic viral hepatitis B treated with bicyclol tablets.
  
  
  METHODS
  Thirty one patients with chronic viral hepatitis B were divided into two groups and were treated with bicyclol orally at doses of 150 mg daily or 75 mg daily for 36 weeds. The histological changes of the livers were observed before and after the treatment.
  
  
  RESULTS
  Compared with pre-treatment findings, there were significant differences in histological activity index in each group (P < 0.01, P < 0.05), there were also significant differences between the two groups (P < 0.05). Decreased inflammatory reaction was also seen (P < 0.05).
  
  
  CONCLUSIONS
  Daily use of 150 mg and 75 mg bicyclol tablets are effective in improving liver histological changes in chronic hepatitis B patients. Bicyclol 150 mg daily was better.
authors.affiliation: Liver Disease Treatment Center, No. 175 Hospital of The People's Liberation Army, Zhangzhou 363000, China.
authors.forename: Rui-dan
authors.initials: RD
authors.lastname: Zheng
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Cheng-run
authors.initials: CR
authors.lastname: Xu
authors.forename: Hai-dong
authors.initials: HD
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001713:Biphenyl Compounds / Q000627:therapeutic use*; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D013607:Tablets; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D001713:Biphenyl Compounds; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006513:Hepatitis B e Antigens; D013607:Tablets; C477843:bicyclol