Recovery of rod-mediated a-wave during light-adaptation in mGluR6-deficient mice.
The purpose of this study was to compare the a-waves of mGluR6-deficient mice (KO) to that of wild-type mice (WT), and to determine whether the light-adapted electroretinogram of the KO mice originate exclusively from cones. Dark-adapted a-waves were recorded under the same conditions from both types of mice. With a 96-cd/m(2) background, the a-wave from both types of mice showed a rapid recovery over a 50-min period. The analysis of the a-waves in KO mice indicated that the recovery was determined mainly by the rod component. The light-adapted b-wave of WT mice showed no corresponding recovery. We conclude that rod contribution must be considered in the analyses of the light-adapted a-waves of KO mice.
Ueda
Yoshiki
Y
Department of Ophthalmology, Nagahama City Hospital, Oh-Inuicho, Nagahama, Shiga, Japan. yueda@nagahama-hp.jp
Tammitsu
Noritomo
N
Imai
Hiroo
H
Honda
Yoshihito
Y
Shichida
Yoshinori
Y
D000221:Adaptation, Ocular; D000818:Animals; D003623:Dark Adaptation; D004596:Electroretinography; D008029:Lighting; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010775:Photic Stimulation / Q000379:methods; D018094:Receptors, Metabotropic Glutamate / Q000172:deficiency* / Q000502:physiology; D012160:Retina / Q000503:physiopathology; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology; D017948:Retinal Rod Photoreceptor Cells / Q000503:physiopathology*
D018094:Receptors, Metabotropic Glutamate; C113897:metabotropic glutamate receptor 6