title: The amyloid-beta precursor protein: integrating structure with biological function.
abstract: Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.
authors.affiliation: Laboratory for Neuronal Cell Biology and Gene Transfer, Department of Human Genetics, Center for Human Genetics, KU Leuven and VIB, Leuven, Belgium.
authors.forename: Constanze
authors.initials: C
authors.lastname: Reinhard
authors.forename: Sébastien S
authors.initials: SS
authors.lastname: Hébert
authors.forename: Bart
authors.initials: B
authors.lastname: De Strooper
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000737:chemistry* / Q000502:physiology*; D000818:Animals; D006801:Humans; D017434:Protein Structure, Tertiary / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D016564:Amyloid beta-Protein Precursor