Tryptophan catabolism: identification and characterization of a new degradative pathway.
A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.
Colabroy
Keri L
KL
Department of Chemistry, Muhlenberg College, Allentown, PA 18104, USA. colabroy@muhlenberg.edu
Begley
Tadhg P
TP
D019342:Acetic Acid / Q000378:metabolism; D001426:Bacterial Proteins / Q000302:isolation & purification; D016956:Burkholderia cepacia / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D008660:Metabolism / Q000235:genetics* / Q000502:physiology*; D005810:Multigene Family; D019289:Pyruvic Acid / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*
D001426:Bacterial Proteins; D019289:Pyruvic Acid; D014364:Tryptophan; D019342:Acetic Acid