Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats.
Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the present study, we demonstrate in both male and ovariectomized female rats that a single physiological dose of either hormone at 30 min after diffuse traumatic brain injury reduces both blood brain barrier permeability and edema formation. We conclude that both hormones may contribute to reduce edema in females after brain injury.
O'Connor
Christine A
CA
Department of Pathology, University of Adelaide, Adelaide, Australia.
Cernak
Ibolja
I
Vink
Robert
R
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001929:Brain Edema / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology; D002199:Capillary Permeability / Q000502:physiology; D004958:Estradiol / Q000502:physiology*; D005260:Female; D008297:Male; D010052:Ovariectomy; D011374:Progesterone / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors
D011374:Progesterone; D004958:Estradiol