Protein lipidation of BACE.
Our research has concentrated upon the protein lipid modification of BACE [beta-site amyloid precursor protein cleaving enzyme (beta-secretase)], of which very little is currently known. Lipidation influences the production of Abeta (amyloid beta-protein) by promoting the dimerization of BACE.
Parsons
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RB
Department of Basic Medical Sciences, St. George's University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK. r.parsons@sgul.ac.uk
Austen
B M
BM
D000544:Alzheimer Disease / Q000628:therapy; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D019308:Palmitic Acid / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D008074:Lipoproteins; D019308:Palmitic Acid; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human