Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors.
NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme.
Franchetti
Palmarisa
P
Dipartimento di Scienze Chimiche, Università di Camerino, Camerino, Italy. palmarisa.franchetti@unicam.it
Petrelli
R
R
Cappellacci
L
L
Pasqualini
M
M
Vita
P
P
Sorci
L
L
Mazzola
F
F
Raffaelli
N
N
Magni
Giulio
G
D000970:Antineoplastic Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D009243:NAD / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D008024:Ligands; D009243:NAD; D009612:Nicotinamide-Nucleotide Adenylyltransferase