A new marker for lipid peroxidation: serum paraoxonase activity in non-alcoholic steatohepatitis.
OBJECTIVE
Relationship between hepatic antioxidant paraoxonase 1 (PON1) activity, lipid peroxidation and liver injury was investigated in patients with non-alcoholic steatohepatitis.


METHODS
A total of 23 patients with non-alcoholic steatohepatitis (15 males, 8 females; mean age: 40.30+/-7.67 yrs) and 23 healthy controls (14 males, 9 females; mean age: 39.70+/- 8.78 yrs) were enrolled in the study. Serum paraoxonase 1 activity and levels of a well-known lipid peroxidation marker, serum malondialdehyde, were determined.


RESULTS
Serum paraoxonase 1 activity decreased significantly in non-alcoholic steatohepatitis compared to the control group (p<0.01). Serum malondialdehyde levels were significantly higher in patients with non-alcoholic steatohepatitis as compared with the control group (p<0.05). No statistically significant correlations were found between serum paraoxonase 1 activities and the grade-stage of non-alcoholic steatohepatitis, serum lipid levels or serum malondialdehyde levels (p>0.05).


CONCLUSIONS
Increased lipid peroxidation may be either a cause or a result of liver injury in patients with non-alcoholic steatohepatitis. Although serum paraoxonase 1 activity does not reflect the degree of liver damage in non-alcoholic steatohepatitis, reduced paraoxonase 1 activity, especially in the presence of mild disease, could be interpreted as a biochemical marker of the lipid peroxidation.
Başkol
Mevlüt
M
Department of Gastroenterology, School of Medicine, Erciyes University, Kayseri, Turkey. mbaskol@erciyes.edu.tr
Başkol
Gülden
G
Deniz
Kemal
K
Ozbakir
Omer
O
Yücesoy
Mehmet
M
D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D005234:Fatty Liver / Q000097:blood / Q000201:enzymology*; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000201:enzymology*; D006526:Hepatitis C / Q000097:blood / Q000201:enzymology*; D006801:Humans; D006937:Hypercholesterolemia / Q000201:enzymology; D015228:Hypertriglyceridemia / Q000201:enzymology; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000201:enzymology; D012720:Severity of Illness Index; D014421:Turkey
D015415:Biomarkers; D008315:Malondialdehyde; D043303:Aryldialkylphosphatase