title: Synthesis of a new N-9 ribityl analogue of cyclic inosine diphosphate ribose (cIDPR) as a mimic of cyclic ADP ribose (cADPR).
abstract: A new analogue of cyclic inosine diphosphate ribose (cIDPR), in which the N-1 and N-9 ribosyl moieties were substituted by a carbocyclic moiety and a hydroxyl-alkyl chain, has been synthesized and characterized.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Napoli, Italy. golivier@unina.it
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.forename: Jussara
authors.initials: J
authors.lastname: Amato
authors.forename: Michela
authors.initials: M
authors.lastname: Varra
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
mesh_terms: D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015195:Drug Design; D006026:Glycoside Hydrolases / Q000737:chemistry; D006868:Hydrolysis; D007288:Inosine / Q000737:chemistry*; D015544:Inositol 1,4,5-Trisphosphate / Q000737:chemistry; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D010710:Phosphates / Q000737:chemistry*; D012266:Ribose / Q000737:chemistry*
chemical_list: D010710:Phosphates; D036563:Cyclic ADP-Ribose; D007288:Inosine; D012266:Ribose; D015544:Inositol 1,4,5-Trisphosphate; D006026:Glycoside Hydrolases