title: Kumada coupling of aryl and vinyl tosylates under mild conditions.
abstract: [Reaction: see text]. Aryl and alkenyl tosylates are easily prepared, inexpensive and, thus, attractive for transition-metal-catalyzed couplings, but their reactivity is low. We report examples of mild, palladium-catalyzed coupling of aryl, alkenyl, and alkyl Grignard reagents with aryl and alkenyl tosylates. The resulting biaryls, vinylarenes, and alkylarenes were isolated in good to excellent yield. These couplings were conducted with a nearly equimolar ratio of the two reactants, and many examples were conducted at room temperature.
authors.affiliation: Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Limmert
authors.forename: Amy H
authors.initials: AH
authors.lastname: Roy
authors.forename: John F
authors.initials: JF
authors.lastname: Hartwig
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000494:pharmacology*; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: D014105:Tosyl Compounds; D010165:Palladium