Genotoxic damage in female residents exposed to environmental air pollution in Shenyang city, China.
Air pollution has been suggested to cause genetic damage from investigations of many biological markers that measure cytogenetic damage in humans. Here, we evaluated the genotoxic effects of ambient air pollution by investigating the extent of cytogenetic damage in human blood lymphocytes from rural and industrial female residents of Shenyang city, China, using micronuclei assays and polymorphic analyses of metabolic enzyme and DNA repair genes. After adjustment for potential confounding factors including DNA polymorphisms, industrial female residents were found to have a higher micronuclei frequency. These results provide evidence that micronuclei assays are a sensitive indicator to air pollution-induced genotoxic effects in humans.
Ishikawa
Hitoshi
H
Department of Public Health and Occupational Medicine, Mie University Graduate School of Medicine, Edobashi 2-174, Tsu 514-8507, Japan. h.iskw@med.id.yamagata-u.ac.jp <h.iskw@med.id.yamagata-u.ac.jp>
Tian
Ying
Y
Piao
Fengyuan
F
Duan
Zhiwen
Z
Zhang
Yumin
Y
Ma
Mingyue
M
Li
Haishan
H
Yamamoto
Hidetaka
H
Matsumoto
Yutaka
Y
Sakai
Shigekatsu
S
Cui
Jinshan
J
Yamauchi
Toru
T
Yokoyama
Kazuhito
K
D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D002274:Carcinogens, Environmental / Q000032:analysis / Q000633:toxicity*; D002681:China; D005260:Female; D005449:Fluorenes / Q000032:analysis / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis / Q000633:toxicity*; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis; D014504:Urban Health
D000393:Air Pollutants; D002274:Carcinogens, Environmental; D005449:Fluorenes; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons; C006703:benzo(b)fluoranthene