Human brain derived cell culture models of HIV-1 infection.
During the clinical course of acquired immune deficiency syndrome, infection of the CNS by human immunodeficiency virus-1 (HIV-1) may ultimately result in the impairment of cognitive, behavioral and motor functions. Viral neuropathogenesis involves inflammatory molecules and neurotoxins produced from infected and immune-activated lymphocytes, microglial cells and astrocytes. Here, we discuss the current understanding of HIV-1 infection of the CNS and various cell culture systems from the developing human brain in order to study the neurobiology of HIV-1 infection, the mechanisms contributing to HIV-1 infection, and disease progression.
Seth
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Molecular and Cellular Neuroscience, National Brain Research Centre, Manesar, India.
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D015526:AIDS Dementia Complex / Q000473:pathology*; D001921:Brain / Q000166:cytology* / Q000473:pathology*; D002478:Cells, Cultured; D015658:HIV Infections / Q000473:pathology*; D015497:HIV-1; D006801:Humans; D013234:Stem Cells / Q000473:pathology / Q000821:virology