Heterotrimeric G proteins and regulation of size asymmetry during cell division.
The generation of daughter cells of different fate and size depends on the orientation, positioning and morphology of the mitotic spindle. In both C. elegans and Drosophila, heterotrimeric G proteins have emerged as central and conserved regulators of this process. Although the same molecular players are involved in worms and flies, there are clear differences in the mechanisms used. Interestingly, recent work in mammalian cells suggests that heterotrimeric G proteins may control spindle positioning in higher organisms during symmetric and asymmetric cell divisions.
Bellaiche
Yohanns
Y
Institut Curie, CNRS UMR 144, 26 rue d'Ulm, Paris, 75248 France.
Gotta
Monica
M
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D048429:Cell Size; D020962:Heterotrimeric GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000737:chemistry
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; C467518:LET-99 protein, C elegans; C404808:lin-5 protein, C elegans; D020962:Heterotrimeric GTP-Binding Proteins