Unusual monomolecular DNA quadruplex structures using bunch-oligonucleotides.
The chemical synthesis of several G-rich bunch-oligonucleotides and the structural characterization of the corresponding monomolecular G-quadruplexes (I-IV) have been reported. The synthetic method allow the achievement of monomolecular DNA quadruplex structures having unusual and predeterminable oligodeoxyribonucleotide (ODN) strand orientation.
Oliviero
Giorgia
G
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Napoli, Italy. golivier@unina.it
Amato
Jussara
J
Borbone
Nicola
N
Galeone
Aldo
A
Varra
Michela
M
Piccialli
Gennaro
G
Mayol
Luciano
L
D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D004247:DNA