Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats.
The aim of this study was to clarify the role of the renal sympathetic nerves in the gamma-aminobutyric acid (GABA)-induced hypotensive effect in spontaneously hypertensive rats. Male spontaneously hypertensive rats (SHR/Izm) aged 7 weeks were divided into four groups on the basis of diet (containing 0.05% GABA, or GABA-free control diet) and operation (renal sympathetic-denervated or sham-operated) (n = 10, each). Water intake, urine volume and urinary sodium were, or tended to be, slightly higher, while plasma renin activity was significantly lower in the GABA group than the GABA-free control group. GABA inhibited the development of hypertension in sham-operated spontaneously hypertensive rats but not in renal-denervated spontaneously hypertensive rats. Plasma renin activity was significantly higher in sham-operated spontaneously hypertensive rats fed the control diet than in the other three groups. These results suggest that a reduction in the effects induced by the renal nerves may play an important role in the hypotensive effect induced in spontaneously hypertensive rats by chronic dietary administration of GABA.
Hayakawa
Kazuhito
K
Yakult Central Institute for Microbiological Research, Kunitachi-shi, Tokyo, Japan. kazuhito-hayakawa@yakult.co.jp
Kimura
Masayuki
M
Yamori
Yukio
Y
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000652:urine; D003714:Denervation; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D007668:Kidney / Q000294:innervation*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors; D014556:Urine; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D003404:Creatinine; D012083:Renin