title: Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors.
abstract: A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
authors.affiliation: ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. jliu@arqule.com
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Wilson
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.forename: Kevin
authors.initials: K
authors.lastname: Sprague
authors.forename: Katie
authors.initials: K
authors.lastname: Sargent
authors.forename: Ying
authors.initials: Y
authors.lastname: Si
authors.forename: Galina
authors.initials: G
authors.lastname: Beletsky
authors.forename: Daniel
authors.initials: D
authors.lastname: Yohannes
authors.forename: Shi-Chung
authors.initials: SC
authors.lastname: Ng
mesh_terms: D000818:Animals; D050256:Antimitotic Agents / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000187:drug effects / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D050256:Antimitotic Agents; D001688:Biological Products; D011799:Quinazolines; D014404:Tubulin