title: [Non-invasive ventilation in neonates with Ondine syndrome: a real indication?].
abstract: Ondine's syndrome is a congenital central hypoventilation syndrome due to a disorder in the autonomic control of breathing in the absence of any primary disease that would explain it. Noninvasive ventilation (NIV) has been reported to be effective in the management of these patients, thus avoiding the need for tracheotomy for prolonged mechanical ventilation. We describe our experience of NIV in infants with Ondine's syndrome. Two infants with Ondine's syndrome were transferred to our center for management and adjustment of therapy. On admission NIV (BiPAP VISION) was started with nasal interphase in S/T (spontaneous/timed) mode, which failed to provide suitable ventilation (PCO2 > 70 mmHg). Finally, tracheotomy for continuous mechanical ventilation was performed. Although NIV has been reported to be successful in some patients with Ondine's syndrome, its application in patients younger than 5 years does not seem to be the general norm of treatment.
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Servicio de Pediatría, Unidad Integrada, Hospital Sant Joan de Déu-Clínic, Universitat de Barcelona, España. curune@yahoo.es
authors.forename: J A
authors.initials: JA
authors.lastname: Costa Orvay
authors.forename: M
authors.initials: M
authors.lastname: Pons Odena
authors.forename: I
authors.initials: I
authors.lastname: Jordán García
authors.forename: J
authors.initials: J
authors.lastname: Caritg Bosch
authors.forename: F J
authors.initials: FJ
authors.lastname: Cambra Lasaosa
authors.forename: A
authors.initials: A
authors.lastname: Palomeque Rico
mesh_terms: D005260:Female; D006801:Humans; D007040:Hypoventilation / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D011175:Positive-Pressure Respiration / Q000379:methods*; D012720:Severity of Illness Index; D020182:Sleep Apnea, Central / Q000503:physiopathology* / Q000628:therapy*