title: [Lethal anaphylactic shock model induced by human mixed serum in guinea pigs].
abstract: OBJECTIVE
  To establish an anaphylactic shock model induced by human mixed serum in guinea pigs.
  
  
  METHODS
  Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.
  
  
  RESULTS
  Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.
  
  
  CONCLUSIONS
  An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.
authors.affiliation: Department of forensic medicine,Shanxi Medical University, Taiyuan 030001, China. renguangmu@163.com
authors.forename: Guang-Mu
authors.initials: GM
authors.lastname: Ren
authors.forename: Ji-Wei
authors.initials: JW
authors.lastname: Bai
authors.forename: Cai-Rong
authors.initials: CR
authors.lastname: Gao
mesh_terms: D000485:Allergens; D000707:Anaphylaxis / Q000097:blood / Q000276:immunology*; D000818:Animals; D003645:Death, Sudden; D004195:Disease Models, Animal; D005260:Female; D005554:Forensic Medicine; D006168:Guinea Pigs; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay; D011897:Random Allocation; D044967:Serum / Q000276:immunology*
chemical_list: D000485:Allergens; D007074:Immunoglobulin G