Multivariate analysis of relationships between iodine biological exposure and subclinical thyroid dysfunctions.
OBJECTIVE
To assess the relationships between iodine biological exposure and subclinical thyroid dysfunctions.


METHODS
The cross-sectional survey was performed to obtain the epidemiologic data of population in three communities with different iodine biological exposure: mild iodine deficiency [median urinary iodine concentration (MUI) of 50-99 microg/L], more than adequate iodine intake (MUI of 200-299 microg/L), and excessive iodine intake (MUI over 300 microg/L). Univariate and multivariate analysis (logistic regression analysis) were used to analyze the risk factors of subclinical hypothyroidism and subclinical hyperthyroidism.


RESULTS
Logistic regression analysis with sex and age controlled suggested that more than adequate iodine intake (OR = 3.172, P = 0.0004) and excessive iodine intake (OR = 6.391, P = 0.0001) increased the risk of subclinical hypothyroidism, while excessive iodine intake decreased the risk of subclinical hyperthyroidism (OR = 0.218, P = 0.0001). Logistic regression analysis including interaction of iodine intake and antibodies [thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb)] suggested that excessive iodine intake was an independent risk factor of subclinical hypothyroidism (OR = 6.360, P = 0.0001), but independent protect factor of subclinical hyperthyroidism (OR = 0.193, P = 0.0001). More than adequate iodine intake and it's interaction with TgAb increased the risk of subclinical hypothyroidism independently, in addition, it decreased the risk of subclinical hyperthyroidism at the present of TPOAb.


CONCLUSIONS
Both excessive iodine intake and more than adequate iodine intake could increase risk of subclinical hypothyroidism, supplement of iodine should be controlled to ensure MUI within the safe range.
Chong
Wei
W
Department of Emergency, First Affiliated Hospital, China Medical University, Shenyang 110001.
Shan
Zhong-Yan
ZY
Sun
Wei
W
Teng
Wei-Ping
WP
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002681:China; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000453:epidemiology / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000453:epidemiology / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000276:immunology*; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects / Q000652:urine; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013954:Thyroglobulin / Q000276:immunology*
D001323:Autoantibodies; D013954:Thyroglobulin; D007455:Iodine; D007453:Iodide Peroxidase