Study of antiparkinsonic activity of panavir on a model of Parkinson syndrome induced by systemic administration of MPTP to outbred rats and C57Bl/6 mice.
The effect of panavir on Parkinson's syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was studied in C57Bl/6 mice and outbred albino rats. Two injections of panavir significantly reduced the severity of oligokinesia and autonomic manifestations of experimentally induced Parkinson's syndrome.
Kalinina
T S
TS
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. tatianakalinina@mail.ru
Nerobkova
L N
LN
Voronina
T A
TA
Stovbun
S V
SV
Litvin
A A
AA
Sergienko
V I
VI
D000818:Animals; D005106:Exploratory Behavior / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009949:Orientation / Q000187:drug effects; D020734:Parkinsonian Disorders / Q000188:drug therapy*; D011341:Probucol / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D018709:Statistics, Nonparametric
D011341:Probucol