title: Polar localization of a soluble methyl-accepting protein of Pseudomonas aeruginosa.
abstract: A soluble methyl-accepting chemotaxis protein (MCP) of Pseudomonas aeruginosa, McpS, showed polar localization by immunofluorescence microscopy. Overexpression of McpS resulted in a dominant-negative effect on chemotaxis and caused a loss of polar clustering of the general MCP population. The polar localization of a soluble MCP defines a third, and unexpected, paradigm for cellular MCP localization.
authors.affiliation: Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, 48109, USA.
authors.forename: Sonia L
authors.initials: SL
authors.lastname: Bardy
authors.forename: Janine R
authors.initials: JR
authors.lastname: Maddock
mesh_terms: D001426:Bacterial Proteins / Q000032:analysis*; D002628:Chemoreceptor Cells; D002633:Chemotaxis; D015870:Gene Expression; D008565:Membrane Proteins / Q000032:analysis*; D008856:Microscopy, Fluorescence; D011550:Pseudomonas aeruginosa / Q000737:chemistry* / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins