A solid support with a hydroxyallyl linker, full parts of which are potentially reusable for the synthesis of oligonucleotides.
This paper describes a solid support with a hydroxyallyl linker that is regenerated without loss of any parts after having used for the synthesis of nucleotides. Reproduction of the solid support can be achieved through detachment of the oligonucleotide by treatment with an organopalladium catalyst in the presence of triethylammonium acetate and subsequent methanolysis of the resulting allyl acetate.
Hyodo
Mamoru
M
Laboratory of Bioorganic Chemistry, Graduate School of Information Science/Human Informatics, and CRESTJST, Nagoya Univetsity, Nagoya, Japan.
Morimura
Mari
M
Hayakawa
Yoshihiro
Y
D000085:Acetates / Q000737:chemistry; D002384:Catalysis; D002412:Cations; D004247:DNA / Q000737:chemistry; D008697:Methane; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D015345:Oligonucleotide Probes / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012313:RNA / Q000737:chemistry
D000085:Acetates; D002412:Cations; D015345:Oligonucleotide Probes; D009841:Oligonucleotides; D010165:Palladium; D012313:RNA; D004247:DNA; D008697:Methane