title: A solid support with a hydroxyallyl linker, full parts of which are potentially reusable for the synthesis of oligonucleotides.
abstract: This paper describes a solid support with a hydroxyallyl linker that is regenerated without loss of any parts after having used for the synthesis of nucleotides. Reproduction of the solid support can be achieved through detachment of the oligonucleotide by treatment with an organopalladium catalyst in the presence of triethylammonium acetate and subsequent methanolysis of the resulting allyl acetate.
authors.affiliation: Laboratory of Bioorganic Chemistry, Graduate School of Information Science/Human Informatics, and CRESTJST, Nagoya Univetsity, Nagoya, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Hyodo
authors.forename: Mari
authors.initials: M
authors.lastname: Morimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D000085:Acetates / Q000737:chemistry; D002384:Catalysis; D002412:Cations; D004247:DNA / Q000737:chemistry; D008697:Methane; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D015345:Oligonucleotide Probes / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D012313:RNA / Q000737:chemistry
chemical_list: D000085:Acetates; D002412:Cations; D015345:Oligonucleotide Probes; D009841:Oligonucleotides; D010165:Palladium; D012313:RNA; D004247:DNA; D008697:Methane