Follicular B helper T cells in antibody responses and autoimmunity.
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4(+) T cells in the tonsils and memory CD4(+) T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.
Vinuesa
Carola G
CG
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australia.
Tangye
Stuart G
SG
Moser
Bernhard
B
Mackay
Charles R
CR
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D051379:Mice; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000096:biosynthesis / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
C095085:CXCR5 protein, human; C513179:CXCR5 protein, mouse; D054380:Receptors, CXCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine