title: Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds from 4-phenylsulfonyl tetrafluoropyridine.
abstract: [Reaction: see text]. Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido[2,3-b]pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.
authors.affiliation: Department of Chemistry and Chemical Crystallography Group, University of Durham, South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Aurelie
authors.initials: A
authors.lastname: Baron
authors.forename: Graham
authors.initials: G
authors.lastname: Sandford
authors.forename: Rachel
authors.initials: R
authors.lastname: Slater
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Yufit
authors.forename: Judith A K
authors.initials: JA
authors.lastname: Howard
authors.forename: Antonio
authors.initials: A
authors.lastname: Vong
mesh_terms: D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D011719:Pyrazines; D011725:Pyridines