Mitomycin C effect on fibrous adhesions of rabbit temporomandibular joint.
OBJECTIVE
To evaluate influence of mitomycin C on fibrosis in temporomandibular joints of rabbits with mandibular traction.


METHODS
Twenty rabbits (8 control, 12 mitomycin C group) were included. Titanium screws were placed in the anterior edge of the right masseter tuberosity and the posterior part of the right zygoma. Elastic bands were placed between 2 screws to initiate posterio-superior displacement of the mandible to the right. Animals in the control group (CG) received intraarticular NaCl (0.9%) on the nondrawing (left) side, and animals in the study group (SG) received mitomycin C weekly (0.4 mg/mL) for 6 weeks. Rabbits were decapitated, temporomandibular joints were removed, and histopathological investigation was performed.


RESULTS
Microscopically, 4 of 6 rabbits in the CG had fibrosis in the temporomandibular joint, whereas only 1 of 11 rabbits in the SG had fibrosis (P < 0.05).


CONCLUSIONS
Application of mitomycin C to the temporomandibular joint of rabbits significantly reduces formation of intraarticular fibrous adhesions.


CONCLUSIONS
This is the first study in the literature investigating the use of mitomycin C in the joints.


METHODS
B-2.
Aydin
Erdinc
E
Department of Otorhinolaryngology, Faculty of Medicine, Baskent University, Ankara, Turkey. erdinca@baskent-ank.edu.tr
Uckan
Sina
S
Ozdemir
B Handan
BH
Uyar
Pinar
P
D000818:Animals; D001707:Biopsy, Needle; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005355:Fibrosis / Q000473:pathology / Q000517:prevention & control; D007150:Immunohistochemistry; D007270:Injections, Intra-Articular; D008297:Male; D016685:Mitomycin / Q000494:pharmacology*; D011336:Probability; D011817:Rabbits; D011897:Random Allocation; D012016:Reference Values; D012680:Sensitivity and Specificity; D013704:Temporomandibular Joint / Q000187:drug effects* / Q000473:pathology*; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy* / Q000473:pathology; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control
D016685:Mitomycin