Synthesis of 2'-C-methyl-beta-D-ribofuranosylimidazo [4,5-d]-pyridazine derivatives (2-aza-3-deazapurine nucleoside analogues).
In order to evaluate their antiviral properties, two imidazo[4,5-d]pyridazine 2'-C-methyl-beta-D-ribofuranonucleoside derivatives have been synthesized.
Leroy
F
F
Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
Dukhan
D
D
Durka
M
M
Chaves
D
D
Bragnier
N
N
Storer
R
R
Gosselin
G
G
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003853:Deoxyribonucleosides / Q000138:chemical synthesis*; D015195:Drug Design; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D011684:Purine Nucleosides / Q000737:chemistry*; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry*; D012266:Ribose / Q000737:chemistry; D013696:Temperature; D013997:Time Factors
D000998:Antiviral Agents; D003853:Deoxyribonucleosides; D011684:Purine Nucleosides; D011724:Pyridazines; D012266:Ribose