[Is there a difference between low-molecular-weight heparins?].
Low-molecular-weight heparins share many properties and are commonly referred to as a group, but structurally and pharmacologically they are dissimilar. The size spectrum of the heparin molecules varies between the different products and as assessed in vitro, their anticoagulant properties differ. In particular, the ratio anti-factor Xa : anti-factor IIa activities varies. The clinical consequences of these differences are unknown. The efficacy and safety of two different low-molecular-weight heparins have been compared in only a few clinical studies; no significant differences in outcome were shown. However, low-molecular-weight heparins should be used according to the approved indication for each product and in doses shown effective and safe in clinical studies. A change from one low-molecular-weight heparin to another in the same patient should be avoided. Fondaparinux is a synthetic penta-saccharide which may be regarded as an extreme low-molecular-weight heparin with a ratio of anti-factor Xa : anti-factor IIa activity as 1 : 0, and with a promising efficacy/safety profile. So far, the approved clinical indication for its use is limited to prophylaxis in orthopaedic surgery.
Eritsland
Jan
J
Hjertemedisinsk avdeling, Ullevål universitetssykehus, 0407 Oslo. jan.eritsland@ulleval.no
D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D003327:Coronary Disease / Q000188:drug therapy; D017985:Dalteparin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D017984:Enoxaparin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D000077425:Fondaparinux; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D015912:Thrombolytic Therapy; D000078222:Tinzaparin; D020246:Venous Thrombosis / Q000188:drug therapy / Q000517:prevention & control
D000925:Anticoagulants; D017984:Enoxaparin; D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D011134:Polysaccharides; D000078222:Tinzaparin; D000077425:Fondaparinux; D017985:Dalteparin