title: Poor clinical course in a child with myelodysplastic syndrome and del(13)(q14q22).
abstract: Myelodysplastic syndromes (MDS) are rare in children, representing 3% or less of all hematopoietic malignancies. Cytogenetic abnormalities, such as -7/7q-, +8, and +21 have been reported in 55-80% of children with MDS. Cytogenetic studies have an important impact on diagnosis, treatment selection, and monitoring therapeutic protocols when combined with morphologic data. We report on a pediatric case of MDS with the presence of the rare clonal abnormality del(13)(q14q22) which underwent a malignant transformation to leukemia and ran a very poor clinical course.
authors.affiliation: Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine, 35340 Balçova, Izmir, Turkey. hale.oren@deu.edu.tr
authors.forename: Hale
authors.initials: H
authors.lastname: Oren
authors.forename: Erdinç
authors.initials: E
authors.lastname: Yüksel
authors.forename: Sebnem
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Meral
authors.initials: M
authors.lastname: Türker
authors.forename: Fatih
authors.initials: F
authors.lastname: Demircioğlu
authors.forename: Gülersu
authors.initials: G
authors.lastname: Irken
mesh_terms: D002675:Child, Preschool; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D017384:Sequence Deletion