title: Contrast-enhanced intraoperative ultrasonography during hepatectomies for colorectal cancer liver metastases.
abstract: Preliminary reports showed that contrast-enhanced intraoperative ultrasonography (CEIOUS) provides information on primary or metastatic tumors of the liver that is not obtainable with conventional intraoperative ultrasonography (IOUS). This study validates the impact of CEIOUS, focusing on resective surgery for colorectal cancer (CRC) liver metastases. Twenty-four consecutive patients underwent liver resection using IOUS and CEIOUS for CRC liver metastases. CEIOUS was accomplished with intravenous injection of 4.8 mL of sulphur-hexafluoride microbubbles. CEIOUS found lesions missed at preoperative imaging and at IOUS in four patients and confirmed all of the new findings of IOUS in four patients. In addition, CEIOUS helped to define the tumor margins of the main lesion in 29% of patients with CRC liver metastases. No adverse effects were observed in relation with CEIOUS. In conclusion, CEIOUS improves IOUS accuracy with a significant impact on surgical strategy and radicality in patients who undergo surgery for CRC liver metastases.
authors.affiliation: Third Department of Surgery, Faculty of Medicine, University of Milan, Istituto Clinico Humanitas, IRCCS, Rozzano (Milano), Italy. guido.torzilli@unimi.it
authors.forename: Guido
authors.initials: G
authors.lastname: Torzilli
authors.forename: Daniele
authors.initials: D
authors.lastname: Del Fabbro
authors.forename: Angela
authors.initials: A
authors.lastname: Palmisano
authors.forename: Matteo
authors.initials: M
authors.lastname: Donadon
authors.forename: Paolo
authors.initials: P
authors.lastname: Bianchi
authors.forename: Massimo
authors.initials: M
authors.lastname: Roncalli
authors.forename: Luca
authors.initials: L
authors.lastname: Balzarini
authors.forename: Marco
authors.initials: M
authors.lastname: Montorsi
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007275:Injections, Intravenous; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D008297:Male; D045423:Microbubbles; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D003287:Contrast Media; D013459:Sulfur Hexafluoride