Vaccines based on Nef and on Nef/DeltaV2 Env.
Modified vaccinia virus Ankara (MVA) is a potent vaccine vector, which proved its safety, immunogenity and efficacy in preclinical and clinical studies. The rational for the development of a vaccine against HIV based on the regulatory protein Nef delivered by MVA combined with a V2-deleted Env protein is discussed.
Erfle
Volker
V
Institute of Molecular Virology, GSF-National Research Center for Environment and Health, Ingolstaedter Landstrasse 1a, 85764 Neuherberg, Germany. erfle@gsf.de
Goebel
Frank D
FD
Guzman
Carlos A
CA
Le Grand
Roger
R
D016915:AIDS Vaccines / Q000009:adverse effects / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use; D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D015686:Gene Products, env / Q000235:genetics / Q000276:immunology*; D015693:Gene Products, nef / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000628:therapy; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D051379:Mice; D023421:Models, Animal; D017778:Vaccines, Combined / Q000235:genetics / Q000276:immunology; D019444:Vaccines, DNA; D022223:Vaccines, Subunit / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D054299:env Gene Products, Human Immunodeficiency Virus; D054311:nef Gene Products, Human Immunodeficiency Virus
D016915:AIDS Vaccines; D015686:Gene Products, env; D015693:Gene Products, nef; C483360:MVA-HIV-1 nef vaccine; D017778:Vaccines, Combined; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D054299:env Gene Products, Human Immunodeficiency Virus; C097729:gp140 envelope protein, Human immunodeficiency virus 1; D054311:nef Gene Products, Human Immunodeficiency Virus