F2928-1 and -2, new antifungal antibiotics from Cladobotryum sp.
Two new antifungal antibiotics, F2928-1 (1) and -2 (2), were isolated from the culture broth of Cladobotryum sp. These compounds were purified by solvent extraction, silica gel column chromatography and preparative HPLC, consecutively. The structures of these compounds were assigned as a decalin compound on the basis of various spectral analyses. These compounds showed antimicrobial activity against fungi including clinically important fungus, Aspergillus fumigatus.
Kanai
Yoshinori
Y
Research Laboratory Agrochemical & Animal Health Products Department, Kaken Pharmaceutical Co., Ltd., 301 Gensuke, Fujieda, Shizuoka 426-8646, Japan. carl-k@syd.odn.ne.jp
Tatsumi
Yoshiyuki
Y
Tokiwa
Toshiyuki
T
Watanabe
Yoko
Y
Fujimaki
Tsukasa
T
Ishiyama
Daisuke
D
Okuda
Toru
T
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004852:Epoxy Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D006999:Hypocreales / Q000737:chemistry* / Q000378:metabolism; D009281:Naphthalenes / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D004852:Epoxy Compounds; C506316:F2928-1; C506315:F2928-2; D009281:Naphthalenes