Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Cpl-1, a pneumococcal phage lytic enzyme, was tested in rats with experimental endocarditis due to Streptococcus pneumoniae WB4. High-dose regimen Cpl-1 eliminated pneumococci from blood within 30 min and decreased bacterial titers in vegetations (>4 log10 CFU/g) within 2 h. Rapid bacterial lysis induced by Cpl-1 treatment increased cytokine secretion noticeably.
Entenza
J M
JM
Department of Fundamental Microbiology, Biology Building, University of Lausanne, CH-1015 Lausanne, Switzerland. Jose.Entenza@unil.ch
Loeffler
J M
JM
Grandgirard
D
D
Fischetti
V A
VA
Moreillon
P
P
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D057487:Enzyme Therapy; D004798:Enzymes; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D051381:Rats
D016207:Cytokines; D004798:Enzymes; C028806:lysin, streptococcus bacteriophage