title: Synthesis of conformationally constrained cyclic peptides using an intramolecular sonogashira coupling.
abstract: [Reaction: see text]. Small peptides having a 3-bromobenzyl group at the C-termini and n-alkynoyl group at the N-termini undergo a smooth copper-free intramolecular Sonogashira coupling reaction to afford the corresponding cyclic peptides in moderate yields. Scope and limitations of this macrocyclization is demonstrated with di-, tri-, and tetrapeptides.
authors.affiliation: Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad, 500 049, A.P., India.
authors.forename: V
authors.initials: V
authors.lastname: Balraju
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
authors.forename: Mariappan
authors.initials: M
authors.lastname: Periasamy
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010456:Peptides, Cyclic; D010165:Palladium; D003300:Copper