Investigations on gossypol: past and present developments.
Gossypol has received significant attention as a result of its potential therapeutic application as a male antifertility agent. Furthermore, recent research examining the biological activity of gossypol has revealed a number of other promising lines of enquiry. These have focused on the antitumour, antiviral and antioxidant actions of the compound in various disease states. This article provides an overview of the studies on the biological activity of gossypol, with particular attention paid to the mechanisms of its activity and its prospect as a medicinal product.
Dodou
Kalliopi
K
Sunderland Pharmacy School, University of Sunderland, Sunderland SR1 3SD, UK. kalliopi.dodou@sunderland.ac.uk
Anderson
Rosaleen J
RJ
Small
David A P
DA
Groundwater
Paul W
PW
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects; D006072:Gossypol / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051336:Mitochondrial Membranes / Q000187:drug effects
D000970:Antineoplastic Agents; D000975:Antioxidants; D000998:Antiviral Agents; D006072:Gossypol