title: 1-Hydroxy-1-norresistomycin, a new cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.
abstract: In our systematic screening programme for marine actinomycetes, a bioactive streptomycete was isolated from marine sediment samples of the Bay of Bengal, India. The isolate yielded a new cytotoxic compound. This was obtained by solvent extraction followed by chromatographic purification. The pure compound was identified from spectroscopic data as a quinone-related antibiotic, 1-hydroxy-1-norresistomycin (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro. It also exhibited antibacterial activities against Gram-positive and Gram-negative bacteria.
authors.affiliation: Biotechnology Division, Dept. of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India.
authors.forename: Adinarayana
authors.initials: A
authors.lastname: Gorajana
authors.forename: Bapiraju V V S N
authors.initials: BV
authors.lastname: Kurada
authors.forename: Sujatha
authors.initials: S
authors.lastname: Peela
authors.forename: Premkumar
authors.initials: P
authors.lastname: Jangam
authors.forename: Saisha
authors.initials: S
authors.lastname: Vinjamuri
authors.forename: Ellaiah
authors.initials: E
authors.lastname: Poluri
authors.forename: Axel
authors.initials: A
authors.lastname: Zeeck
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D011721:Pyrenes / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: C506325:1-hydroxy-1-norresistomycin; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D011721:Pyrenes