Skin cancer in organ transplant recipients: effect of pretransplant end-organ disease.
BACKGROUND
Solid organ transplant recipients are at increased risk for posttransplant neoplasms.


OBJECTIVE
Our purpose was to determine whether various diseases causing end-organ failure are associated with different degrees of risk of skin cancer development after transplantation.


METHODS
The Organ Procurement and Transplantation Network/United Network for Organ Sharing Transplant Tumor Registry was searched for the incidence of skin cancer among kidney, liver, and heart transplant recipients in the United States between 1996 and 2001. Multivariate analysis was used to determine the association between disease diagnosis and posttransplant skin cancer.


RESULTS
Transplant recipients with specific pretransplant diseases, such as polycystic kidney disease and cholestatic liver disease, were at increased risk for skin cancer. Patients with diabetes mellitus had a lower incidence of skin cancer after kidney transplantation.


CONCLUSIONS
The study had only a brief follow-up period, indirect assessment of photodamage, and possible underreporting.


CONCLUSIONS
Transplant recipients with a history of certain diseases warrant intensive skin cancer surveillance and strict sun-protective practices.
Otley
Clark C
CC
Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Cherikh
Wida S
WS
Salasche
Stuart J
SJ
McBride
Maureen A
MA
Christenson
Leslie J
LJ
Kauffman
H Myron
HM
D000293:Adolescent; D000328:Adult; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology*