title: Landiolol attenuates the cardiovascular response to tracheal intubation.
abstract: OBJECTIVE
  The objective of this prospective study was to compare the cardiovascular responses with or without landiolol to the induction of general anesthesia and tracheal intubation.
  
  
  METHODS
  Twenty-two patients were randomly allocated to receive a loading dose of landiolol 125 microg kg(-1) min(-1) for 1 min followed by an infusion at 40 microg kg(-1) min(-1) for 4 min, or placebo. Four minutes after landiolol or placebo was started, propofol and succinylcholine were administered. Laryngoscopy and tracheal intubation were performed 1 min after the administration of succinylcholine. Heart rate and blood pressure were measured noninvasively every minute.
  
  
  RESULTS
  A significant attenuation of the heart rate and blood pressure response were seen in the landiolol group for 3 min after intubation. Heart rate and systolic blood pressure in the landiolol group were decreased for 2 min before intubation and just before intubation compared with baseline, respectively.
  
  
  CONCLUSIONS
  Continuous administration of landiolol before tracheal intubation results in the attenuation of cardiovascular response for tracheal intubation.
authors.affiliation: Department of Anesthesiology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Goyagi
authors.forename: Makoto
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D011229:Preanesthetic Medication; D015742:Propofol; D011446:Prospective Studies; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D018686:Anesthetics, Intravenous; D009025:Morpholines; C077049:landiolol; D014508:Urea; D015742:Propofol