Review of immediate-release omeprazole for the treatment of gastric acid-related disorders.
Immediate-release omeprazole (Zegerid, Santarus) is the first immediate-release oral proton pump inhibitor to reach the market. As a powder formulation for oral suspension, it is indicated for the treatment of gastroesophageal reflux disease, erosive oesophagitis, duodenal ulcer and gastric ulcer, and is the only proton pump inhibitor approved for the reduction of risk of upper gastrointestinal bleeding in critically ill patients. Administration of immediate-release omeprazole at bedtime results in a rapid and sustained elevation of gastric pH, and seems to provide better night time control of gastric acidity than that observed with conventional morning dosing of delayed-release proton pump inhibitors. The immediate-release formulation may provide a good treatment option for patients who require flexible dosing, quick onset of action and nocturnal gastric acid control.
Castell
Donald
D
Esophageal Disorders Program, Medical University of South Carolina, CSB Box 250327, Charleston, SC 29425, USA. castell@musc.edu
D000284:Administration, Oral; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002940:Circadian Rhythm; D004304:Dosage Forms; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D009853:Omeprazole / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000378:metabolism; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000378:metabolism; D054328:Proton Pump Inhibitors; D016032:Randomized Controlled Trials as Topic
D000897:Anti-Ulcer Agents; D004304:Dosage Forms; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors; D009853:Omeprazole