title: Strain driven fast osseointegration of implants.
abstract: BACKGROUND
  Although the bone's capability of dental implant osseointegration has clinically been utilised as early as in the Gallo-Roman population, the specific mechanisms for the emergence and maintenance of peri-implant bone under functional load have not been identified. Here we show that under immediate loading of specially designed dental implants with masticatory loads, osseointegration is rapidly achieved.
  
  
  METHODS
  We examined the bone reaction around non- and immediately loaded dental implants inserted in the mandible of mature minipigs during the presently assumed time for osseointegration. We used threaded conical titanium implants containing a titanium2+ oxide surface, allowing direct bone contact after insertion. The external geometry was designed according to finite element analysis: the calculation showed that physiological amplitudes of strain (500-3,000 ustrain) generated through mastication were homogenously distributed in peri-implant bone. The strain-energy density (SED) rate under assessment of a 1 Hz loading cycle was 150 Jm-3 s-1, peak dislocations were lower then nm.
  
  
  RESULTS
  Bone was in direct contact to the implant surface (bone/implant contact rate 90%) from day one of implant insertion, as quantified by undecalcified histological sections. This effect was substantiated by ultrastructural analysis of intimate osteoblast attachment and mature collagen mineralisation at the titanium surface. We detected no loss in the intimate bone/implant bond during the experimental period of either control or experimental animals, indicating that immediate load had no adverse effect on bone structure in peri-implant bone.
  
  
  CONCLUSIONS
  In terms of clinical relevance, the load related bone reaction at the implant interface may in combination with substrate effects be responsible for an immediate osseointegration state.
authors.affiliation: Department of Cranio-Maxillofacial Surgery, University of Münster, Waldeyerstrasse, Münster, Germany. Joos@uni-muenster.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Joos
authors.forename: Andre
authors.initials: A
authors.lastname: Büchter
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Wiesmann
authors.forename: Ulrich
authors.initials: U
authors.lastname: Meyer
mesh_terms: D015921:Dental Implants; D006801:Humans; D008334:Mandible / Q000473:pathology* / Q000601:surgery; D016348:Osseointegration / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: D015921:Dental Implants