Unprecedented asymmetric induction through configurationally stable lithium N-(alpha-methylbenzyl)phosphinamides. A new entry to enantiomerically pure gamma-aminophosphinic acids and esters.
The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral gamma-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown.
Fernández
Ignacio
I
Area de Química Orgánica, Universidad de Almería, Carretera de Sacramento, 04120, Almería, Spain.
Gómez
Gloria Ruiz
GR
Alfonso
Ignacio
I
Iglesias
María J
MJ
Ortiz
Fernando López
FL