Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease.
In the last decade, it has become more apparent the important role genes play in the development of late-onset Alzheimer's disease (AD). Great efforts, involving human genome scans and candidate gene studies, have been given towards identifying susceptibility genes for AD. A number of regions on different chromosomes have been reported to demonstrate linkage for AD. Of these, findings on chromosome 12 are some of the most compelling. Worldwide genetic association studies pre-dating and subsequent to recent linkage studies have identified and focused upon a number of genes that map to the areas of reported linkage on chromosome 12, however, analyses of those genes studied to date, on the whole, remain inconclusive and ambiguous. This paper reviews studies that have provided evidence of linkage for AD on chromosome 12 and in turn discusses the work conducted to date on candidate genes that have been identified and map to the chromosome 12 regions of interest.
D'Introno
Alessia
A
Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy.
Solfrizzi
Vincenzo
V
Colacicco
Anna Maria
AM
Capurso
Cristiano
C
Amodio
Margherita
M
Todarello
Orlando
O
Capurso
Antonio
A
Kehoe
Patrick G
PG
Panza
Francesco
F
D000544:Alzheimer Disease / Q000235:genetics*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D004268:DNA-Binding Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics; D016615:Telomere / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011973:Receptors, LDL; C501906:TFCP2 protein, human; D014157:Transcription Factors