[Pressure stress in glaucoma--assessment through classical techniques and computational modelling].
Even if glaucoma remains a major eye illness with unknown etiology, the importance of vascular factors associated with mechanical factors contributing to the pathogenesis and development of glaucomatous optic neuropathy has been emphasized. the objective of the study consists in elaboration of a biomechanical model of the human eye correlated with clinical and ultrasonography evaluations aiming to early identification of changes induced by pressure stress in open angle glaucoma (OAG) at retrobulbar arteries and optic nerve head level.


METHODS
The present study included a lot formed by 97 patients without glaucoma, aged 20-75 years (lot 1) and a lot formed by 71 patients with open angle glaucoma, aged 45-80 years (lot 2). We used usual methods in ophthalmological examinations and diagnosis (bottom ocular fundus examinations eye examinations, visual - field examinations, measurements of PIO), ultrasonography methods (CDI, pulsed Doppler, spectral Doppler and power-angio), computational modelling methods for ocular structures.


CONCLUSIONS
In open angle glaucoma color Doppler imaging shows changes in retrobulbar hemodynamic for most of the studied cases, ultrasonography techniques being considered as an important tool for the diagnosis and progression control in glaucomatous damage. Limitations of ultrasonography techniques consist of early identification of these alterations and can be improved by the elaboration of a biomechanical model of the human eye that will permit an abstraction and generalisation of the hemodynamic aspects with the aim of simulation of changes induced by high intraocular pressure on retrobulbar arteries level, the possibility of viewing these changes in their dynamics (on lower pressure values than 30 mmHg).
Mercuţ
Georgeta
G
Spitalul Militar Craiova.
Rinderu
Elena Taina
ET
Andriţoiu
A C
AC
Gruionu
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003936:Diagnosis, Computer-Assisted; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods; D013312:Stress, Physiological; D014065:Tonometry, Ocular; D018615:Ultrasonography, Doppler, Color / Q000379:methods; D014794:Visual Fields