An unexpected wide population variation of the G1733A polymorphism of the androgen receptor gene: data on the Mediterranean region.
The androgen receptor (AR) has been proposed as a candidate gene for several cancers (breast, prostate, uterine endometrium, colon, and esophagus). Ethnicity is considered an associated risk factor for some of these cancers. Several case-control genetic studies have been focused in samples of the main ethnic groups, but little is known about the distribution of risk polymorphisms in current populations with accurate ethnic and/or geographic origins. The A allele of the G1733A polymorphism of the AR gene has been associated with increased risk of prostate cancer. We provide data from this marker in 12 samples from 7 Mediterranean countries such as Spain, Italy (Sardinia), Greece, Turkey, Morocco, Algeria, and Egypt. A sample from Ivory Coast has also been analyzed. The A allele distribution shows a frequency in the Ivory Coast population (65.17%) that contrasts with the low values found in Northern Mediterraneans (mean average value of 13.98%). North African populations present two-times higher frequencies (average value of 27.19%) than Europeans. The wide population variation range found for the A allele strengthens the potential interest of further screening as a baseline to the design of future preventive and population health programs.
Esteban
E
E
Department of Animal Biology-Anthropology, Faculty of Biology, University of Barcelona, Barcelona, Spain. mesteban@ub.edu
Via
M
M
González-Pérez
E
E
Santamaría
J
J
Dugoujon
J M
JM
Vona
G
G
Harich
N
N
Luna
F
F
Saetta
A A
AA
Bissar
N
N
Moral
P
P
D000483:Alleles; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008297:Male; D019083:Mediterranean Region / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011944:Receptors, Androgen / Q000097:blood / Q000235:genetics*
D004273:DNA, Neoplasm; D011944:Receptors, Androgen