title: [Experimental study on the osseointegration of nanophase hydroxyapatite biograde-coated implants].
abstract: OBJECTIVE
  To study the osseointegration of the nanophase hydroxyapatite biograde-coated implants and host bone.
  
  
  METHODS
  Nanophase hydroxyapatite biograde-coated implants, hydroxyapatite biograde-coated implants and noncoated Ti-6Al-4V implants were inserted into both femoral of Beagle canines the tissue response, dynamic osteogensis and SEM were studied at 4, 8 and 12 weeks.
  
  
  RESULTS
  The degradation of nanophase hydroxyapatite was slower than hydroxyapatite, dynamic osteogensis and the form of osteoblast were better than the control groups.
  
  
  CONCLUSIONS
  The biological reaction of Nanophase hydroxyapatite biograde-coated implants is better than hydroxyapatite coated implant.
authors.affiliation: Department of Orthopaedic, Ruijn Hospital, Shanghai Second Medical University, Shanghai 200025, China. nealwang@hotmail.com
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Tan
authors.forename: Qing-ming
authors.initials: QM
authors.lastname: Yang
authors.forename: Lian-fu
authors.initials: LF
authors.lastname: Deng
authors.forename: Shao-xian
authors.initials: SX
authors.lastname: Zeng
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004285:Dogs; D017886:Durapatite / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D053758:Nanoparticles; D016348:Osseointegration / Q000502:physiology; D013499:Surface Properties
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite