Models of epilepsy in the developing and adult brain: implications for neuroprotection.
Repeated seizures cause a sequence of molecular and cellular changes in both the developing and adult brain, which may lead to intractable epilepsy. This article reviews this sequence of neuronal alterations, with emphasis on the kindling model. At each step, the opportunity exists for strategic intervention to prevent or reduce the downstream consequences of epileptogenesis and seizure-induced adverse plasticity. The concept of seizure-induced brain damage must be expanded to include behavioral and cognitive deficits, as well as structural neuronal damage and increased predisposition to seizures.
Stafstrom
Carl E
CE
Department of Neurology, University of Wisconsin, Madison, WI 53792, USA. stafstrom@neurology.wisc.edu
Sutula
Thomas P
TP
D000328:Adult; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000503:physiopathology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D018696:Neuroprotective Agents