Rodent model systems for studies of HIV-1 associated dementia.
Understanding of HIV-1 neuropathogenesis and development of rationale therapeutic approaches requires relevant animal models. The putative mechanisms of neuroinflammatory and neurotoxic events triggered by HIV-1 brain infection are reflected by a number of rodent models. These include transgenic animals (either expressing viral proteins or pro-inflammatory factors), infection with murine retroviruses, and severe combined immunodeficient (SCID) mice reconstituted with human lymphocytes and injected intracerebrally with HIV-1-infected human monocyte-derived macrophages. The potential importance and limitations of the models in reflecting human disease are discussed with emphasis on their utility for development of therapies to combat HIV-1-associated neurologic impairment.
Persidsky
Y
Y
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA. ypersids@unmc.edu
Potula
R
R
Haorah
J
J
D015526:AIDS Dementia Complex / Q000473:pathology* / Q000523:psychology*; D000818:Animals; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000473:pathology / Q000523:psychology; D015497:HIV-1; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D008822:Mice, Transgenic; D051381:Rats; D012190:Retroviridae