title: Comparison of the levels of heat resistance of wild-type, cpe knockout, and cpe plasmid-cured Clostridium perfringens type A strains.
abstract: An enterotoxin (cpe) plasmid was cured from a Clostridium perfringens non-food-borne gastrointestinal disease (NFBGID) isolate, and the heat resistance levels of wild-type, cpe knockout, and cpe plasmid-cured strains were compared. Our results demonstrated that (i) wild-type cpe has no influence in mediating high-level heat resistance in C. perfringens and (ii) the cpe plasmid does not confer heat sensitivity on NFBGID isolates.
authors.affiliation: Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
authors.forename: Deepa
authors.initials: D
authors.lastname: Raju
authors.forename: Mahfuzur R
authors.initials: MR
authors.lastname: Sarker
mesh_terms: D001427:Bacterial Toxins / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D003016:Clostridium perfringens / Q000235:genetics / Q000254:growth & development* / Q000502:physiology*; D004768:Enterotoxins / Q000235:genetics; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D018869:Heat-Shock Response; D006358:Hot Temperature; D010957:Plasmids / Q000235:genetics*; D013171:Spores, Bacterial / Q000235:genetics / Q000254:growth & development; D010738:Type C Phospholipases / Q000235:genetics*
chemical_list: D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D004768:Enterotoxins; C035598:enterotoxin, Clostridium; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens