title: Role of mitogen-activated protein (MAP) kinases in cardiovascular diseases.
abstract: Over the last decade important advances have been made in our understanding of the molecular events underlying cellular responses to extracellular signals. Increased understanding of signal transduction mechanisms and gene regulation involved in cardiovascular diseases has created opportunities for the discovery of novel therapeutic compounds useful for the treatment of cardiovascular disorders. One of the best-studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway, which plays a crucial role in many aspects of cardiovascular responses. Here, our current understanding of the MAP kinase pathway is reviewed, as well as recent advances in the design of novel agents that are able to modulate the activity of these signaling cascades.
authors.affiliation: Department of Pharmacology, C. U. Shah College of Pharmacy and Research, Wadhwan City-363030, Dist. Surendranagar, India. pandyapharmacist@rediffmail.com
authors.forename: Nilesh
authors.initials: N
authors.lastname: Pandya
authors.forename: Dev
authors.initials: D
authors.lastname: Santani
authors.forename: Sunita
authors.initials: S
authors.lastname: Jain
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends
chemical_list: D020928:Mitogen-Activated Protein Kinases