[The role of protein conformational disturbances in the pathomechanism of the extrapyramidal system diseases].
Neurodegenerative disorders are characterised by cell damage due to accumulation of toxic, pathologic proteins. Mutations in genes coding different cell proteins result in conformational disturbances of the protein structure, their accumulation and aggregation manifested at the level of light microscope as various intracellular inclusions. This paper is an attempt of approach to cellular mechanisms underlying neurodegenerative diseases of the extrapyramidal system with special attention to ubiquitin-proteasome pathway -- the pathway whose discoverers received the 2004 Nobel Prize in chemistry.
Dziewulska
Dorota
D
Klinika i Katedra Neurologii, Akademia Medyczna, ul. Banacha 1a, 02-097 Warszawa. ddziewul@amwaw.edu.pl
Rafałowska
Janina
J
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005116:Extrapyramidal Tracts / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D051844:alpha-Synuclein / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D011506:Proteins; D025801:Ubiquitin; D051844:alpha-Synuclein; D016875:tau Proteins; D046988:Proteasome Endopeptidase Complex