Intensity-modulated radiotherapy as the boost or salvage treatment of nasopharyngeal carcinoma: the appropriate parameters in the inverse planning and the effect of patient's anatomic factors on the planning results.
The current study demonstrates that the large increase in normal tissue penalty often degrades target dose uniformity without a concomitant large improvement in normal tissue dose, especially in anatomically unfavorable patients. The excessively large normal tissue penalties do not improve treatment plans for patients having unfavorable geometry.
Hsiung
Ching-Yeh
CY
Department of Radiation Oncology, Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung Hsien, Taiwan, ROC. hsiungcy@hotmail.com
Hunt
Margie A
MA
Yorke
Ellen D
ED
Chui
Chen-Shou
CS
Hu
Jason
J
Xiong
Jian-Ping
JP
Ling
Clifton C
CC
Lo
Sing-Kai
SK
Wang
Chong-Jong
CJ
Huang
Eng-Yen
EY
Amols
Howard I
HI
D002277:Carcinoma / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology* / Q000517:prevention & control*; D020266:Radiotherapy, Conformal / Q000379:methods*; D016879:Salvage Therapy