title: Complete resolution of hepatic aspergillosis after non-myeloablative hematopoietic stem cell transplantation in a patient with acute myeloid leukemia.
abstract: Fungal infections due to Aspergillus are a frequent cause of transplant-related mortality. For this reason, leukemic patients with severe fungal infection are usually excluded from conventional allotransplantation. Recently, some authors suggested a role for non-myeloablative hematopoietic stem cell transplantation (HSCT) in this subset of patients. We used this therapeutic approach in a patient with high-risk acute myeloid leukemia in second complete remission (CR) with pre-existing hepatic aspergillosis refractory to conventional anti-fungal therapy. A complete regression of hepatic lesions was observed after 3 months from allogeneic stem cell transplantation. Our work confirms previous reports suggesting that non-myeloablative HSCT is effective in patients not eligible for conventional transplantation because of invasive aspergillosis.
authors.affiliation: Division of Hematology and Hematopoietic Stem Cell Transplantation, University of Siena, Italy. marotta@unisi.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marotta
authors.forename: Monica
authors.initials: M
authors.lastname: Tozzi
authors.forename: Simona
authors.initials: S
authors.lastname: Sammassimo
authors.forename: Marzia
authors.initials: M
authors.lastname: Defina
authors.forename: Donatella
authors.initials: D
authors.lastname: Raspadori
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gozzetti
authors.forename: Francesco
authors.initials: F
authors.lastname: Lauria
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D008099:Liver / Q000000981:diagnostic imaging / Q000382:microbiology; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D011859:Radiography; D019172:Transplantation Conditioning / Q000379:methods
chemical_list: D000935:Antifungal Agents