title: [A device for fluorescence diagnosis and photodynamic therapy of eye diseases, by using photosense].
abstract: By having a high photodynamic effectiveness and an ability of fluorescence, a Photosense photosensibilizer provides a way of combining photodynamic therapy (PDT) and monitoring its control within a session, which enhances the efficiency of treatment for the subretinal neovascular membrane. A slit lamp-based apparatus complex has been developed to employ the methods of fluorescence diagnosis (FD) and PDT, by applying this photosensitizer. The complex comprises an optical adapter that focusing laser radiation on the fundus of the eye in a range of 100-1000 microm, a video adapter that includes color and high-sensitive monochromic video cameras, as well as a personal computer and software that processes video information from the high-sensitive camera and displays the obtained images in real time. The original system of filters provides an image of the eye fundus in the fluorescent and usual color light at once during a FR procedure. The spatial resolution of the developed apparatus was tested on the test object specially devised for these purposes, which was 10 microm. The sensitivity of the complex is sufficient to record slightly fluorescent objects on the fundus of the eye.
authors.forename: S A
authors.initials: SA
authors.lastname: Shevchik
authors.forename: M V
authors.initials: MV
authors.lastname: Loshchenov
authors.forename: G A
authors.initials: GA
authors.lastname: Meerovich
authors.forename: M V
authors.initials: MV
authors.lastname: Budzinskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Ermakova
authors.forename: S S
authors.initials: SS
authors.lastname: Kharnas
authors.forename: V B
authors.initials: VB
authors.lastname: Loshchenov
mesh_terms: D005453:Fluorescence; D005456:Fluorescent Dyes; D005654:Fundus Oculi; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007211:Indoles / Q000627:therapeutic use; D008838:Microcomputers; D008991:Monitoring, Physiologic; D009885:Ophthalmology / Q000295:instrumentation*; D009942:Organometallic Compounds / Q000627:therapeutic use; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D015861:Retinal Neovascularization / Q000175:diagnosis* / Q000188:drug therapy*; D012680:Sensitivity and Specificity; D012984:Software; D014741:Video Recording
chemical_list: D005456:Fluorescent Dyes; D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C048577:aluminum tetrasulfophthalocyanine