title: Brain damage after heat stroke.
abstract: Cerebellar syndromes and radiologic cerebellar atrophy after hyperpyrexia have occasionally been reported, mostly in neuroleptic malignant syndromes, but neuropathologic studies are extremely rare. We studied 3 patients (a 74-year-old woman, a 63-year-old man, and an 80-year-old man) who had heat stroke during heat waves in France. One patient had generalized seizures and died 28 hours after admission. The other patients survived one month and 2 months after admission; both had palatal myoclonus, and in one case, magnetic resonance imaging showed high signal intensity in the cerebral peduncles. The main neuropathology in the 3 cases was severe diffuse loss of Purkinje cells associated with heat shock protein 70 expression by Bergmann glia. In situ end labeling was negative in surviving Purkinje cells, suggesting that the mechanism of neuronal death was not apoptosis. Degeneration of Purkinje cells axons resulted in myelin pallor of the white matter of the folia and of the hilum of the dentate nuclei. DNA internucleosomal breakages were identified by in situ end labeling in the dentate nuclei and centromedian nuclei of the thalamus and were associated with degeneration of the cerebellar efferent pathways: superior cerebellar peduncles, decussation of the superior cerebellar peduncles (Wernekinck commissure), and dentatothalamic tract. These findings suggest that the mechanisms of neuronal death in the dentate nuclei and centromedian nuclei of the thalamus was different from that in Purkinje cells and more likely resulted from deafferentation. Ammon's horn and other areas susceptible to hypoxia were spared. These observations confirm the selective vulnerability of Purkinje cells to heat-induced injury and involvement of the cerebellar efferent pathways in palatal myoclonus.
authors.affiliation: Service Central d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisière, Paris, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Bazille
authors.forename: Bruno
authors.initials: B
authors.lastname: Megarbane
authors.forename: Dan
authors.initials: D
authors.lastname: Bensimhon
authors.forename: Anne
authors.initials: A
authors.lastname: Lavergne-Slove
authors.forename: Anne Catherine
authors.initials: AC
authors.lastname: Baglin
authors.forename: Philippe
authors.initials: P
authors.lastname: Loirat
authors.forename: France
authors.initials: F
authors.lastname: Woimant
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Mikol
authors.forename: Françoise
authors.initials: F
authors.lastname: Gray
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001927:Brain Diseases / Q000209:etiology* / Q000378:metabolism; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D018883:Heat Stroke / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged
chemical_list: D018840:HSP70 Heat-Shock Proteins