Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
Veazey
Ronald S
RS
Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433, USA.
Springer
Martin S
MS
Marx
Preston A
PA
Dufour
Jason
J
Klasse
Per Johan
PJ
Moore
John P
JP
D000284:Administration, Oral; D000818:Animals; D065100:CCR5 Receptor Antagonists; D005260:Female; D008251:Macaca / Q000821:virology*; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*; D013997:Time Factors; D014621:Vagina / Q000187:drug effects / Q000821:virology*; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D019562:Viral Load
D065100:CCR5 Receptor Antagonists; C480490:CMPD 167; D011720:Pyrazoles; D014633:Valine