title: Progress in modeling of protein structures and interactions.
abstract: The prediction of the structures and interactions of biological macromolecules at the atomic level and the design of new structures and interactions are critical tests of our understanding of the interatomic interactions that underlie molecular biology. Equally important, the capability to accurately predict and design macromolecular structures and interactions would streamline the interpretation of genome sequence information and allow the creation of macromolecules with new and useful functions. This review summarizes recent progress in modeling that suggests that we are entering an era in which high-resolution prediction and design will make increasingly important contributions to biology and medicine.
authors.affiliation: Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
authors.forename: Ora
authors.initials: O
authors.lastname: Schueler-Furman
authors.forename: Chu
authors.initials: C
authors.lastname: Wang
authors.forename: Phil
authors.initials: P
authors.lastname: Bradley
authors.forename: Kira
authors.initials: K
authors.lastname: Misura
authors.forename: David
authors.initials: D
authors.lastname: Baker
mesh_terms: D003198:Computer Simulation; D003205:Computing Methodologies; D008958:Models, Molecular; D011487:Protein Conformation