title: Phenolic and triterpene glycosides from the stems of Ilex litseaefolia.
abstract: Chemical investigation on the stems of Ilex litseaefolia afforded four new phenolic glycosides, litseaefolosides A-D (1-4), and two new triterpene glycosides, spathodic acid 28-O-beta-d-glucopyranoside (5) and (20S)-niga-ichigoside F1 (6), along with 28 known compounds. The structures of 1-6 were determined on the basis of chemical and spectroscopic evidence. Litseaefoloside C (3) showed inhibitory activities in vitro for alpha-glucosidase and lipase with IC(50) values of 34.0 and 0.31 microg/mL, respectively.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
authors.forename: Ai-Lian
authors.initials: AL
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Ye
authors.forename: Bo-Gang
authors.initials: BG
authors.lastname: Li
authors.forename: Hua-Yi
authors.initials: HY
authors.lastname: Qi
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Zhang
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030017:Ilex / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008049:Lipase / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D010636:Phenols; D014315:Triterpenes; C505676:litseaefoloside C; D008049:Lipase