Solid lipid nanoparticles containing tamoxifen characterization and in vitro antitumoral activity.
Solid lipid nanoparticles (SLNs) containing tamoxifen, a nonsteroidal antiestrogen used in breast cancer therapy, were prepared by microemulsion and precipitation techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration, and in vitro plasmatic drug release studies demonstrated that these systems are able to give a prolonged release of the drug in the intact form. Preliminary study of antiproliferative activity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. The results of characterization studies and of in vitro antiproliferative activity strongly support the potential application of tamoxifen-loaded SLNs as a carrier system at prolonged release useful for intravenous administration in breast cancer therapy.
Fontana
Giacomo
G
Dipartimento di Chimica e Tecnologie Farmaceutiche, Università di Palermo, Palermo, Italy. gfontana@unipa.it
Maniscalco
Laura
L
Schillaci
Domenico
D
Cavallaro
Gennara
G
Giammona
Gaetano
G
D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry*; D049329:Nanostructures; D000442:Octanols / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013629:Tamoxifen / Q000737:chemistry* / Q000494:pharmacology; D013997:Time Factors; D014867:Water / Q000737:chemistry
D018931:Antineoplastic Agents, Hormonal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; D000442:Octanols; D014867:Water; D013629:Tamoxifen