title: Synthesis of homo-N-nucleoside with 1,2,4-triazole-3-carboxamide.
abstract: On the basis of potent biological activities of ribavirin and homo-N-nucleosides, a novel homo-N-1,2,4-triazole-3-carboxamide derivative 1 was synthesized starting from 2,3,5-tri-O-benzoylribofuranosyl-1-acetate as a potential antiviral agent.
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Myong Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Bo Ram
authors.initials: BR
authors.lastname: Kim
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003486:Cyanides / Q000737:chemistry; D004261:DNA Replication / Q000187:drug effects; D015195:Drug Design; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry; D012254:Ribavirin / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D003486:Cyanides; D009705:Nucleosides; D009711:Nucleotides; D014230:Triazoles; D014297:Trimethylsilyl Compounds; C017957:1,2,4-triazole-3-carboxamide; D012254:Ribavirin; C058010:trimethylsilyl cyanide