Differential brain activation according to chronic social reward frustration.
Neural correlates of reward frustration are increasingly studied in humans. In line with prediction error theory, omission of an expected reward is associated with relative decreases of cerebral activation in dopaminergic brain areas. We investigated whether a history of chronic work-related reward frustration influences this reward-dependent activation pattern by means of functional magnetic resonance imaging. Solving arithmetic tasks was followed by either monetary reward or omission of reward. Hyperactivations in the medial prefrontal, anterior cingulate and dorsolateral prefrontal cortex were observed in a group of healthy adults with high susceptibility to reward frustration as compared with a group with low susceptibility. Findings indicate a compromised ability of adapting brain activation among those suffering form chronic social reward frustration.
Siegrist
Johannes
J
Department of Medical Sociology, University of Duesseldorf, Duesseldorf, Germany. seigrist@uni-duesseldorf.de
Menrath
Ingo
I
Stöcker
Tony
T
Klein
Martina
M
Kellermann
Thilo
T
Shah
N Jon
NJ
Zilles
Karl
K
Schneider
Frank
F
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002908:Chronic Disease; D004298:Dopamine / Q000502:physiology; D005639:Frustration; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012201:Reward; D012919:Social Behavior; D013315:Stress, Psychological / Q000503:physiopathology*
D004298:Dopamine