Synthesis of monodisperse biodegradable microgels in microfluidic devices.
Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 mum sized monodisperse microgels by emulsifying an aqueous dextran-hydroxyethyl methacrylate (dex-HEMA) phase within an oil phase at the junction of microfluidic channels. Dex-HEMA microgels are biodegradable and are ideally suited for the controlled delivery of proteins.
De Geest
Bruno G
BG
Urbanski
John Paul
JP
Thorsen
Todd
T
Demeester
Jo
J
De Smedt
Stefaan C
SC
D001672:Biocompatible Materials; D005782:Gels; D008689:Methacrylates / Q000737:chemistry; D044085:Microfluidics / Q000295:instrumentation*; D008853:Microscopy; D014466:Ultraviolet Rays
D001672:Biocompatible Materials; D005782:Gels; D008689:Methacrylates; C005044:hydroxyethyl methacrylate