title: Increased thickness of the carotid artery intima-media assessed by ultrasonography in Behçet's disease.
abstract: OBJECTIVE
  Behçets disease (BD), is a unique systemic vasculitis, which affects almost all types and sizes of blood vessels. Carotid intima-media thickness (IMT) is an endothelial cell dysfunction (ECD) parameter which may also be associated with atherosclerosis. We aimed to search carotid IMT and plaque formation in BD, using high-resolution B-mode Doppler ultrasonography (USG).
  
  
  METHODS
  We studied 114 BD patients (M/F: 68/46; mean age 38.15 +/- 9.44 years; disease duration 121 +/- 79 months), being followed up by Ege University Rheumatology Department. Age and sex-matched, 77 healthy controls, and as the disease control group 46 non-matched SLE patients were also included. Exclusion criteria for all the study participants were hypertension, hyperlipidemia, diabetes mellitus, obesity and history of cardiovascular or cerebrovascular disease. Comparison of the three groups were made by ANOVA and for post-hoc confirmation, Bonferoni test was used.
  
  
  RESULTS
  The carotid IMT in BD (mean +/- SD, 0.55 +/- 0.14 mm) was significantly higher than in healthy controls (0.48 +/- 0.09 mm) (p = 0.004), but significantly lower than in SLE (0.66 +/- 0.24 mm) (p = 0.001). Likewise, plaque frequency in BD (5/114) was significantly higher than in healthy controls (0/77), but significantly lower than in SLE (8/46) (p < 0.001).
  
  
  CONCLUSIONS
  Despite significantly higher carotid IMT and plaque frequency in BD compared with healthy controls, these parameters in BD were not as marked as in SLE. Less severe carotid artery abnormalities in BD, may partially explain why cardiovascular morbidity and mortality do not seem to be increased in BD, unlike in SLE.
authors.affiliation: Department of Rheumatology, Radiology, Ege University School of Medicine, Izmir, Turkey. agkkeser@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Keser
authors.forename: K
authors.initials: K
authors.lastname: Aksu
authors.forename: S
authors.initials: S
authors.lastname: Tamsel
authors.forename: M
authors.initials: M
authors.lastname: Ozmen
authors.forename: G
authors.initials: G
authors.lastname: Kitapcioglu
authors.forename: C
authors.initials: C
authors.lastname: Kabaroglu
authors.forename: R
authors.initials: R
authors.lastname: Killi
authors.forename: O
authors.initials: O
authors.lastname: Bayindir
authors.forename: E
authors.initials: E
authors.lastname: Doganavsargil
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D001528:Behcet Syndrome / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D017540:Tunica Media / Q000000981:diagnostic imaging*; D018615:Ultrasonography, Doppler, Color / Q000379:methods*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL