title: Breast conservation therapy for breast cancer: patient profile and treatment outcome at a tertiary care cancer centre.
abstract: BACKGROUND
  Breast conservation therapy is a well-established treatment modality for early breast cancer. It is not widely practised in developing countries because of a lack of awareness and treatment facilities, and physician and patient bias. We analysed our experience of breast conservation therapy.
  
  
  METHODS
  We retrospectively reviewed 102 patients who had undergone breast conservation surgery and axillary dissection for breast cancer. Surgery was followed by 45 Gy of radiation to the whole breast and 15-20 Gy of tumour bed boost. All high risk patients received adjuvant systemic therapy. The disease profile, morbidity and treatment outcome were analysed.
  
  
  RESULTS
  Out of 902 patients, 102 underwent breast conservation therapy (90 had early breast cancer and 12 had locally advanced breast cancer). Only 19.6% of patients with early breast cancer received breast conservation therapy. One-third of the patients had had a prior surgical intervention. The mean tumour size was 2.8 cm, 44% had nodal involvement and 29% were oestrogen- and progesterone-receptor negative. At a mean follow up of 32 months, only 1 patient had local recurrence, and the 5-year projected disease-free and overall survival were 82% and 88%, respectively.
  
  
  CONCLUSIONS
  Breast conservation therapy should be offered to suitable breast cancer patients. Strict adherence to protocol-based therapy and active multidisciplinary coordination are crucial for a successful breast conservation therapy programme. Education of the patient as well as the physician population is necessary for increasing the breast conservation therapy rates in India.
authors.affiliation: Department of Surgical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. svsdeo@yahoo.co.in
authors.forename: S V S
authors.initials: SV
authors.lastname: Deo
authors.forename: A
authors.initials: A
authors.lastname: Samaiya
authors.forename: N K
authors.initials: NK
authors.lastname: Shukla
authors.forename: B K
authors.initials: BK
authors.lastname: Mohanti
authors.forename: V
authors.initials: V
authors.lastname: Raina
authors.forename: J
authors.initials: J
authors.lastname: Purkayastha
authors.forename: M
authors.initials: M
authors.lastname: Bhutani
authors.forename: M
authors.initials: M
authors.lastname: Kar
authors.forename: S
authors.initials: S
authors.lastname: Hazarika
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016896:Treatment Outcome