title: The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women.
abstract: Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus, burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.
authors.affiliation: Faculty of Management, Tel Aviv University, Tel Aviv, Israel. tokersha@post.tau.ac.il
authors.forename: Sharon
authors.initials: S
authors.lastname: Toker
authors.forename: Arie
authors.initials: A
authors.lastname: Shirom
authors.forename: Itzhak
authors.initials: I
authors.lastname: Shapira
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
authors.forename: Samuel
authors.initials: S
authors.lastname: Melamed
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D001007:Anxiety / Q000097:blood* / Q000175:diagnosis; D015992:Body Mass Index; D002055:Burnout, Professional; D002097:C-Reactive Protein / Q000378:metabolism*; D003863:Depression / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
chemical_list: D005340:Fibrinogen; D002097:C-Reactive Protein