Privileged structure-based quinazolinone natural product-templated libraries: identification of novel tubulin polymerization inhibitors.
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
Liu
Ji-Feng
JF
ArQule, Inc., 19 Presidential Way, Woburn, MA 01801, USA. jliu@arqule.com
Wilson
Christopher J
CJ
Ye
Ping
P
Sprague
Kevin
K
Sargent
Katie
K
Si
Ying
Y
Beletsky
Galina
G
Yohannes
Daniel
D
Ng
Shi-Chung
SC
D000818:Animals; D050256:Antimitotic Agents / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000187:drug effects / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D050256:Antimitotic Agents; D001688:Biological Products; D011799:Quinazolines; D014404:Tubulin