Intestinal dysmotility in inflammatory bowel disease: mechanisms of the reduced activity of smooth muscle contraction.
Inflammation suppresses intestinal motility, which secondarily induces abnormal growth of intestinal flora. Disturbance of this flora plays a role in the pathogenesis of mucosal inflammation, which in turn aggravates the intestinal dysmotility. Therefore, it is important to know the mechanism of alteration in motor function in the inflamed intestine. Recent studies have shown molecular mechanisms responsible for the motility disorder in the inflamed gut. These include an increase in the activity of myosin light-chain phosphatase and an alteration of ion channel activity in smooth muscle cells.
Ozaki
Hiroshi
H
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan. aozaki@mail.ecc.u-tokyo.ac.jp
Hori
Masatoshi
M
Kinoshita
Kazuya
K
Ohama
Takashi
T
D000818:Animals; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005769:Gastrointestinal Motility; D015212:Inflammatory Bowel Diseases / Q000378:metabolism / Q000503:physiopathology*; D007410:Intestinal Diseases / Q000503:physiopathology; D008954:Models, Biological; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology*
D018925:Chemokines; D016207:Cytokines