title: Prosit, an online service to calculate pseudorotational parameters of nucleosides and nucleotides.
abstract: The online service PROSIT (Pseudo-Rotational Online Service and Interactive Tool) is a free service available at http://cactus.nci.nci.gov/prosit/ that performs pseudorotational analysis of nucleosides(tides). PROSIT reads the 3D coordinates of nucleosides and returns the pseudorotational phase angle P, puckering amplitude vmax and other related information. As examples, the sugar conformations in a parallel-stranded guanine tetraplex and a four-way Holliday junction are presented here.
authors.affiliation: Laboratory of Medicinal Chemistry, NCI-Frederick, CCR, NCI, NIH, DHHS, Frederick, Maryland, USA.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Sun
authors.forename: Johannes H
authors.initials: JH
authors.lastname: Voigt
authors.forename: Victor E
authors.initials: VE
authors.lastname: Marquez
authors.forename: Marc C
authors.initials: MC
authors.lastname: Nicklaus
mesh_terms: D000465:Algorithms; D030561:Databases, Nucleic Acid; D020407:Internet; D008956:Models, Chemical; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D012263:Ribonucleosides / Q000737:chemistry; D012984:Software
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D012263:Ribonucleosides