title: Multi organ transplantation: a review of the Irish experience.
abstract: As the criteria for organ transplantation have broadened, multi organ transplantation has become more common. Calcineurin inhibitor induced end stage renal failure is a common indication for kidney transplantation. We present our experience of 12 kidney transplants, in 11 patients, over a period of 9 years all in the setting of multi-organ transplantation. Kaplan-Meier survival estimates were applied. Estimated patient survival at 1, 3 and 5 years post transplant was 100%, 83% and 66% respectively. Estimated graft survival at 1, 3 and 5 years was 90%, 79% and 63% respectively. The estimated median renal graft survival was 6.2 years. Calcineurin inhibitor toxicity was the most common cause of end stage renal failure in this series of patients. There is a very fine balance between ideal immunosuppression for kidney and other organ transplants. Patients who avoid morbidity such as sepsis or graft rejection enjoy good graft function at 5 years post transplant.
authors.affiliation: Department of Transplantation, Beaumont Hospital, Dublin, Ireland. curranjn@eircom.net
authors.forename: J N
authors.initials: JN
authors.lastname: Curran
authors.forename: P J
authors.initials: PJ
authors.lastname: Conlon
authors.forename: P
authors.initials: P
authors.lastname: O'Kelly
authors.forename: D P
authors.initials: DP
authors.lastname: Hickey
mesh_terms: D016572:Cyclosporine / Q000009:adverse effects*; D006085:Graft Survival; D016027:Heart Transplantation / Q000706:statistics & numerical data*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007494:Ireland; D007676:Kidney Failure, Chronic / Q000139:chemically induced* / Q000601:surgery; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine