Bacteriocin (mutacin) production by Streptococcus mutans genome sequence reference strain UA159: elucidation of the antimicrobial repertoire by genetic dissection.
Streptococcus mutans UA159, the genome sequence reference strain, exhibits nonlantibiotic mutacin activity. In this study, bioinformatic and mutational analyses were employed to demonstrate that the antimicrobial repertoire of strain UA159 includes mutacin IV (specified by the nlm locus) and a newly identified bacteriocin, mutacin V (encoded by SMU.1914c).
Hale
John D F
JD
Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin, New Zealand.
Ting
Yi-Tian
YT
Jack
Ralph W
RW
Tagg
John R
JR
Heng
Nicholas C K
NC
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis*; D019295:Computational Biology; D016680:Genome, Bacterial; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis; D012015:Reference Standards; D034361:Streptococcus mitis / Q000187:drug effects; D013295:Streptococcus mutans / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D019533:Streptococcus oralis / Q000187:drug effects
D001426:Bacterial Proteins; D001430:Bacteriocins; C425769:mutacin IV