title: Automated methodology for determination of stress distribution in human abdominal aortic aneurysm.
abstract: Knowledge of impending abdominal aortic aneurysm (AAA) rupture can help in surgical planning. Typically, aneurysm diameter is used as the indicator of rupture, but recent studies have hypothesized that pressure-induced biomechanical stress may be a better predictor Verification of this hypothesis on a large study population with ruptured and unruptured AAA is vital if stress is to be reliably used as a clinical prognosticator for AAA rupture risk. We have developed an automated algorithm to calculate the peak stress in patient-specific AAA models. The algorithm contains a mesh refinement module, finite element analysis module, and a postprocessing visualization module. Several aspects of the methodology used are an improvement over past reported approaches. The entire analysis may be run from a single command and is completed in less than 1 h with the peak wall stress recorded for statistical analysis. We have used our algorithm for stress analysis of numerous ruptured and unruptured AAA models and report some of our results here. By current estimates, peak stress in the aortic wall appears to be a better predictor of rupture than AAA diameter. Further use of our algorithm is ongoing on larger study populations to convincingly verify these findings.
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA. ml-raghavan@uiowa.edu
authors.forename: Madhavan L
authors.initials: ML
authors.lastname: Raghavan
authors.forename: Mark F
authors.initials: MF
authors.lastname: Fillinger
authors.forename: Steven P
authors.initials: SP
authors.lastname: Marra
authors.forename: Bernhard P
authors.initials: BP
authors.lastname: Naegelein
authors.forename: Francis E
authors.initials: FE
authors.lastname: Kennedy
mesh_terms: D000465:Algorithms; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis* / Q000503:physiopathology*; D001185:Artificial Intelligence; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D011379:Prognosis; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D033081:Shear Strength; D013314:Stress, Mechanical