title: [The influenza season 2004/'05 in the Netherlands with the largest epidemic of the last 5 years caused by the virus variant A/California and the composition of the vaccine for the season 2005/'06].
abstract: In the Netherlands, the influenza epidemic of the 2004/'05 season started late. The background value of 3 cases of an influenza-like illness per 10,000 inhabitants per week was exceeded from week 1 until week 14 of 2005. The magnitude of the epidemic was the largest of the last 5 years, namely 104 per 10,000 inhabitants. As usual, the epidemic was caused mainly by influenza-A viruses of subtype H3N2 and to a lesser degree by A/H1N1 and B viruses. The H3N2-virus isolates belonged to the newly emerged variant A/California/7/04, which deviated slightly from the vaccine strain used for the 2004/'05 season. The influenza-B and H1N1 viruses matched the corresponding vaccine viruses well. For the 2005/'06 season, the World Health Organization has recommended the following vaccine composition: A/California/7/04 (H3N2), A/New Caledonia/20/99 (HiNI), and B/Shanghai/361/02.
authors.affiliation: Erasmus MC, afd. Virologie, Postbus 1738, 3000 DR Rotterdam. jc.de.jong@wxs.nl
authors.forename: J C
authors.initials: JC
authors.lastname: de Jong
authors.forename: G F
authors.initials: GF
authors.lastname: Rimmelzwaan
authors.forename: A I M
authors.initials: AI
authors.lastname: Bartelds
authors.forename: A
authors.initials: A
authors.lastname: Meijer
authors.forename: R A M
authors.initials: RA
authors.lastname: Fouchier
authors.forename: A D M E
authors.initials: AD
authors.lastname: Osterhaus
mesh_terms: D014943:Global Health; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D009426:Netherlands / Q000453:epidemiology; D011159:Population Surveillance; D012621:Seasons
chemical_list: D007252:Influenza Vaccines