title: Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma.
abstract: OBJECTIVE
  In the present study, the effects of magnesium sulfate (MgSO4) on tissue lactate and malondialdehyde (MDA) levels after spinal cord trauma (SCT) in rabbits were studied.
  
  
  METHODS
  Thirty New Zeland rabbits. Interventions. The rabbits were divided equally into three groups: group I was the sham- operated group, group II suffered from SCT but received no treatment, group III was given a dose of 100 mg/kg of magnesium sulfate intravenously at 5th minute after SCT. MEASUREMENTS. The lactate and MDA levels were measured in contused spinal cord tissue at 60 minutes after SCT. There was a significant increase of lactate and MDA levels in group II (p < 0.05) when compared with groups I and III, and a significant increase in the level of MDA in group III compared with group I, and also a significant decrease compared with group II, which was the trauma group without treatment (p < 0.05).
  
  
  CONCLUSIONS
  The findings of this study showed that magnesium sulfate can attenuate the increase of tissue MDA and supply a normalization of lactate levels following SCT which may be related to the neuroprotective effects of (MgSO4).
authors.affiliation: Orthopedics and Traumatology Department, Selcuk University, Meram Faculty of Medicine, Konya, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozdemir
authors.forename: Sahika Liva
authors.initials: SL
authors.lastname: Cengiz
authors.forename: M
authors.initials: M
authors.lastname: Gürbilek
authors.forename: T C
authors.initials: TC
authors.lastname: Oğün
authors.forename: M E
authors.initials: ME
authors.lastname: Ustün
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D006339:Heart Rate; D019344:Lactic Acid / Q000378:metabolism*; D008278:Magnesium Sulfate / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D011897:Random Allocation; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology
chemical_list: D002245:Carbon Dioxide; D019344:Lactic Acid; D008315:Malondialdehyde; D008278:Magnesium Sulfate; D010100:Oxygen