[Effect of Shuanghuang Shengbai granule on radiotherapy or chemotherapy induced leukopenia in mice].
OBJECTIVE
To observe the effect of Shuanghuang Shengbai granule on mice leukopenia induced by ip cyclophosphamide (CTX) or radiation.


METHODS
Mice leukopenia models were induced by ip CTX or radiation, and then treated with Shuanghuang Shengbai granule per oral. The peripheral hemogram, thymus index, spleen index, bone marrow nucleated cell (BMNC) and colony forming unit-spleen (CFU-S) were detected. The bone marrow cell differentiation was examined. The pathological slices of bone marrow were observed.


RESULTS
Shuanghuang Shengbai granule could increase the WBC, BMNC, CFU-S of model mice significantly; Shuanghuang Shengbai granule could make the granulocyte and erythrocyte index recovered to normal level and it could also protect the bone marrow hemotopoietic microenvironment from the harm of radiation.


CONCLUSIONS
Shuanghuang Shengbai granule has apparent leukogenic function.
Shen
Yun-hui
YH
Department of Pharmacology, Shanghai University of Traditional Chinese Madicine, Shanghai 201203, China.
Chen
Chang-xun
CX
Xu
Zhen-ye
ZY
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D002452:Cell Count; D002588:Cesium Radioisotopes; D003520:Cyclophosphamide; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004906:Erythrocyte Count; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D013234:Stem Cells / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014916:Whole-Body Irradiation
D002588:Cesium Radioisotopes; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide