title: Systemic delivery versus elution of drugs that enhance device performance.
abstract: Questions are being raised as to whether it is better to deliver a drug systemically or via a controlled-release mechanism in situations where it is intended that the drug would enhance medical device performance. The issues are addressed here in relation to cardiovascular devices and orthopaedics.
authors.affiliation: Clinical Engineering Department, Royal Liverpool University Hospital, UK. dfw.ce@liverpool.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Williams
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage*; D004333:Drug Administration Routes; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006350:Heart Valve Prosthesis; D006801:Humans; D007595:Joint Prosthesis; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D013673:Technology Assessment, Biomedical; D013923:Thromboembolism / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants