title: Hyperbaric oxygen-induced changes in bacterial translocation and acinar ultrastructure in rat acute necrotizing pancreatitis.
abstract: BACKGROUND
  We aimed to investigate the effects of hyperbaric oxygen therapy on bacterial translocation and acinar cell ultrastructure in a rat model of acute necrotizing pancreatitis.
  
  
  METHODS
  Forty-eight male Sprague-Dawley rats were randomly divided into three groups. Acute pancreatitis was induced in groups II and III. Groups I and II did not receive any treatment, and group III was treated with hyperbaric oxygen. All surviving animals were killed 48 h after the induction of pancreatitis. Bacterial translocation and histological and ultrastructural changes were determined.
  
  
  RESULTS
  The incidence of bacterial translocation in group III was significantly lower in comparison with group II (P<0.001). Histopathological and ultrastructural injury scores were also significantly lower in group III (P<0.001 and P<0.04, respectively).
  
  
  CONCLUSIONS
  Hyperbaric oxygen therapy displayed beneficial effects on pancreatic superinfection and or histopathological and ultrastructural changes in experimental necrotizing pancreatitis.
authors.affiliation: Department of Anatomy, Hacettepe School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Nuket
authors.initials: N
authors.lastname: Mas
authors.forename: Ahmet Turan
authors.initials: AT
authors.lastname: Isik
authors.forename: M Refik
authors.initials: MR
authors.lastname: Mas
authors.forename: Bilgin
authors.initials: B
authors.lastname: Comert
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Salih
authors.initials: S
authors.lastname: Deveci
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozyurt
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Ates
authors.forename: Levent
authors.initials: L
authors.lastname: Yamanel
authors.forename: Huseyin
authors.initials: H
authors.lastname: Doruk
authors.forename: Nuran
authors.initials: N
authors.lastname: Yener
mesh_terms: D000818:Animals; D018988:Bacterial Translocation; D006931:Hyperbaric Oxygenation; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000382:microbiology* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley