title: An unexpected wide population variation of the G1733A polymorphism of the androgen receptor gene: data on the Mediterranean region.
abstract: The androgen receptor (AR) has been proposed as a candidate gene for several cancers (breast, prostate, uterine endometrium, colon, and esophagus). Ethnicity is considered an associated risk factor for some of these cancers. Several case-control genetic studies have been focused in samples of the main ethnic groups, but little is known about the distribution of risk polymorphisms in current populations with accurate ethnic and/or geographic origins. The A allele of the G1733A polymorphism of the AR gene has been associated with increased risk of prostate cancer. We provide data from this marker in 12 samples from 7 Mediterranean countries such as Spain, Italy (Sardinia), Greece, Turkey, Morocco, Algeria, and Egypt. A sample from Ivory Coast has also been analyzed. The A allele distribution shows a frequency in the Ivory Coast population (65.17%) that contrasts with the low values found in Northern Mediterraneans (mean average value of 13.98%). North African populations present two-times higher frequencies (average value of 27.19%) than Europeans. The wide population variation range found for the A allele strengthens the potential interest of further screening as a baseline to the design of future preventive and population health programs.
authors.affiliation: Department of Animal Biology-Anthropology, Faculty of Biology, University of Barcelona, Barcelona, Spain. mesteban@ub.edu
authors.forename: E
authors.initials: E
authors.lastname: Esteban
authors.forename: M
authors.initials: M
authors.lastname: Via
authors.forename: E
authors.initials: E
authors.lastname: González-Pérez
authors.forename: J
authors.initials: J
authors.lastname: Santamaría
authors.forename: J M
authors.initials: JM
authors.lastname: Dugoujon
authors.forename: G
authors.initials: G
authors.lastname: Vona
authors.forename: N
authors.initials: N
authors.lastname: Harich
authors.forename: F
authors.initials: F
authors.lastname: Luna
authors.forename: A A
authors.initials: AA
authors.lastname: Saetta
authors.forename: N
authors.initials: N
authors.lastname: Bissar
authors.forename: P
authors.initials: P
authors.lastname: Moral
mesh_terms: D000483:Alleles; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008297:Male; D019083:Mediterranean Region / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D011944:Receptors, Androgen / Q000097:blood / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D011944:Receptors, Androgen