title: On the multifunctionality of cholinesterases.
abstract: Here we present novel information on non-classical functions of cholinesterases and on a cross-talk linking the two enzymes AChE and BChE. The first part of the article is focussed on the regulation of ChEs and the effects acquired when one of the proteins is knocked down (siRNA for BChE, AChE knock-out mouse). In the second part evidence is presented showing that AChE may exert adhesive properties through its binding to laminin, thus being involved in cell-matrix or cell-cell communication.
authors.affiliation: Darmstadt University of Technology, Developmental Biology and Neurogenetics, Schnittspahnstrasse 3, D-64287 Darmstadt, Germany.
authors.forename: P G
authors.initials: PG
authors.lastname: Layer
authors.forename: K
authors.initials: K
authors.lastname: Allebrandt
authors.forename: P
authors.initials: P
authors.lastname: Andermann
authors.forename: E
authors.initials: E
authors.lastname: Bodur
authors.forename: R
authors.initials: R
authors.lastname: Boopathy
authors.forename: A H
authors.initials: AH
authors.lastname: Bytyqi
authors.forename: L E
authors.initials: LE
authors.lastname: Paraoanu
mesh_terms: D000110:Acetylcholinesterase / Q000235:genetics / Q000378:metabolism*; D000581:Amidohydrolases / Q000378:metabolism; D000818:Animals; D002091:Butyrylcholinesterase / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D007797:Laminin / Q000378:metabolism; D051379:Mice; D011485:Protein Binding; D051381:Rats
chemical_list: D007797:Laminin; C121346:laminin 1; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D000581:Amidohydrolases; C019732:aryl acylamidase