Gold DNA-conjugates: ion specific self-assembly of gold nanoparticles via the dG-quartet.
The Oxytricha telomere DNA hairpin 5'-d(G4T4G4) immobilized on 13 nm gold nanoparticles forms a supramolecular assembly via dGC-quartets, as determined by the color change and by SEM. The aggregation is ion-dependent and selective for sodium ions. K+ is less efficient while Li+ and Cs+ do not drive the aggregation. This work is the first effort exploring the use of secondary structures of DNA (quadruplexes) for producing self-assemblies of gold nanoparticles.
Seela
Frank
F
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Osnabrück, Germany.
Jawalekar
Anup M
AM
Chi
Lifeng
L
Zhong
Dingyong
D
Fuchs
Harald
H
D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006147:Guanine / Q000737:chemistry; D007477:Ions; D046911:Macromolecular Substances; D008855:Microscopy, Electron, Scanning; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D049329:Nanostructures / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes; D011188:Potassium / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D016615:Telomere / Q000648:ultrastructure; D014466:Ultraviolet Rays
D007477:Ions; D046911:Macromolecular Substances; D009692:Nucleic Acid Heteroduplexes; D006147:Guanine; D006046:Gold; D004247:DNA; D012964:Sodium; C008183:isoguanine; D011188:Potassium