[Effect of shensong yangxin capsule on ventricular premature beat and cardiovascular autonomic nervous function in patients with coronary heart disease].
OBJECTIVE
To observe the clinical efficacy of shensong yangxin capsule (SYC) on ventricular premature beat (VPB) differentiated in TCM as palpitation of Qi-yin deficiency syndrome or Xin collateral stagnation syndrome, and cardiovascular autonomic nervous function in patients with coronary heart disease (CHD).


METHODS
The randomized, double-blind, parallel contrast method was adopted, patients were randomly assigned by 3:1 ratio into two groups. One hundred and sixty-five patients in SYC treated group and 56 in the control group (treated with Xinlvning tablet), and the therapeutic course for both groups was 4 weeks.


RESULTS
The clinical efficacy on VPB and in improving TCM syndromes was better in SYC group than that in the control group (P < 0.01). After treatment, the heart rate variability (HRV) and QT dispersion in the two groups were improved in a certain degree. The changes of SDNN, SDANN, SDNN Index and PNN50 in the two groups were significantly different (P < 0.05, P < 0.01), the efficacy in the treated group was superior to that in the control group.


CONCLUSIONS
SYC has definite effect on VPB and TCM Syndromes, it can obviously meliorate the activity of cardiovascular autonomic nervous system in the patients with CHD.
Gu
Chun-hua
CH
Medicinal Academy, Shijiazhuang. gugu8888@126.com
Wu
Yi-ling
YL
Tian
Shu-yan
SY
Gao
Xuedong
X
Qi
Xiaolin
X
Jia
Zhenhua
Z
Yang
Libo
L
Li
Yunpeng
Y
Xu
Guicheng
G
D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D002214:Capsules; D003327:Coronary Disease / Q000150:complications* / Q000188:drug therapy; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D018879:Ventricular Premature Complexes / Q000188:drug therapy* / Q000209:etiology
D002214:Capsules; D004365:Drugs, Chinese Herbal