Epstein-Barr virus: inhibition of apoptosis as a mechanism of cell transformation.
Epstein-Barr virus is a potent mitogen for human B lymphocytes and is associated with a large number of human malignancies. This large virus expresses several genes that may contribute to the transformed phenotype of infected cells and it possesses multiple strategies for the inhibition of apoptosis. The interferon-inducible protein kinase PKR is an important target for the anti-apoptotic actions of the virus and its activity is regulated by the small untranslated RNA, EBER-1. This review summarizes the mechanisms of action of EBER-1 and other Epstein-Barr virus gene products in the regulation of apoptosis, and presents a model of how EBER-1 exerts its effects on PKR activity.
Clemens
Michael J
MJ
Translational Control Group, Centre for Molecular and Metabolic Signalling, Division of Basic Medical Sciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. M.Clemens@sgul.ac.uk
D017209:Apoptosis / Q000502:physiology*; D001402:B-Lymphocytes / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D009690:Nucleic Acid Conformation; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D019892:eIF-2 Kinase / Q000378:metabolism
C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral; D019892:eIF-2 Kinase