title: Phomoxins B and C: polyketides from an endophytic fungus of the genus Eupenicillium.
abstract: Chemical investigations of the culture broth from an endophytic fungus Eupenicillium sp. have afforded two natural products phomoxins B (1) and C (2) as well as the previously reported fungal metabolite eupenoxide (3). Compounds 1 and 2 both contain a cyclic carbonate moiety that is rare among natural products. This paper reports the full spectroscopic characterisation of phomoxins B (1) and C (2) by NMR, UV, IR and MS data. All compounds were inactive against a panel of nosocomial microbes.
authors.affiliation: Chemical Biology Program, Eskitis Institute, Griffith University, Brisbane, Qld 4111, Australia. r.davis@griffith.edu.au
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Vesna
authors.initials: V
authors.lastname: Andjic
authors.forename: Michael
authors.initials: M
authors.lastname: Kotiw
authors.forename: Roger G
authors.initials: RG
authors.lastname: Shivas
mesh_terms: D004353:Drug Evaluation, Preclinical; D032641:Eurotiales / Q000737:chemistry*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; C508101:Phomoxin B; C508100:Phomoxin C; C495645:eupenoxide