1-Hydroxy-1-norresistomycin, a new cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.
In our systematic screening programme for marine actinomycetes, a bioactive streptomycete was isolated from marine sediment samples of the Bay of Bengal, India. The isolate yielded a new cytotoxic compound. This was obtained by solvent extraction followed by chromatographic purification. The pure compound was identified from spectroscopic data as a quinone-related antibiotic, 1-hydroxy-1-norresistomycin (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro. It also exhibited antibacterial activities against Gram-positive and Gram-negative bacteria.
Gorajana
Adinarayana
A
Biotechnology Division, Dept. of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India.
Kurada
Bapiraju V V S N
BV
Peela
Sujatha
S
Jangam
Premkumar
P
Vinjamuri
Saisha
S
Poluri
Ellaiah
E
Zeeck
Axel
A
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D011721:Pyrenes / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C506325:1-hydroxy-1-norresistomycin; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D011721:Pyrenes