[New insights in the pathogenesis of secondary hyperparathyroidism].
Parathyroid gland growth is a major cause of secondary hyperparathyroidism in renal failure. It is well known that high serum phosphate levels, low serum calcium levels and vitamin D deficiency are the three promoters of parathyroid hyperplasia in renal failure. Recent studies have investigated in depth the potential role of growth factors (transforming growth factor alpha) and their receptors (epidermal growth factor receptor) in the pathogenesis of parathyroid cell hyperplasia in chronic renal failure. The identification of molecular mechanisms involved in calcium, phosphate and vitamin D manipulations in an experimental renal failure model could help design more effective therapy for secondary hyperparathyroidism in uremic patients.
Cozzolino
M
M
U.O. Nefrologia e Dialisi, Azienda Ospedaliera San Paolo, Polo Universitario, Milan. mariocozzolino@hotmail.com
Butti
A
A
Chiarelli
G
G
Rocca-Rey
L
L
Bellasi
A
A
Galassi
A
A
Gallieni
M
M
Brancaccio
D
D
D002118:Calcium / Q000097:blood / Q000172:deficiency; D066246:ErbB Receptors / Q000097:blood; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology* / Q000473:pathology; D006965:Hyperplasia; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology; D010280:Parathyroid Glands / Q000473:pathology*; D010710:Phosphates / Q000097:blood; D016211:Transforming Growth Factor alpha / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
D010710:Phosphates; D016211:Transforming Growth Factor alpha; D066246:ErbB Receptors; D002118:Calcium