E Pluribus Unum: 3' end formation of polyadenylated mRNAs, histone mRNAs, and U snRNAs.
The 3' ends of almost all eukaryotic RNAs are generated by nucleolytic cleavage. Remarkably, three groups now demonstrate that similar or identical endonucleases of the metallo-beta-lactamase family generate the 3' ends of polyadenylated mRNAs, nonpolyadenylated histone mRNAs, and U snRNAs.
Weiner
Alan M
AM
Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington 98195, USA.
D000818:Animals; D005057:Eukaryotic Cells / Q000201:enzymology; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D026723:Polyadenylation / Q000235:genetics*; D026721:RNA 3' End Processing / Q000502:physiology*; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism*; D012342:RNA, Small Nuclear / Q000737:chemistry / Q000378:metabolism*; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism
D006657:Histones; D012333:RNA, Messenger; D012342:RNA, Small Nuclear; D001618:beta-Lactamases