title: Second primary malignancy of the aerodigestive tract in patients treated for cancer of the oral cavity and larynx.
abstract: BACKGROUND
  We aimed to identify patterns and predictors of second primary malignancy (SPM) of the aerodigestive tract (SPMADT) in patients with squamous cell carcinoma of the oral cavity (SCCOC) and larynx (SCCL).
  
  
  METHODS
  One thousand two hundred fifty-seven patients from two existing databases were studied: 595 with SCCOC (1986-1995) and 662 with SCCL (1984-1998). The primary endpoint of interest was development of SPMADT, defined as a second primary neoplasm of the head and neck, esophagus, or lung.
  
  
  RESULTS
  The 5-year SPMADT rate was 8% in the SCCL versus 10% in the SCCOC subgroup. Lung SPM was more common in the SCCL group; head and neck SPM was more common in the SCCOC group. Smokers had a fivefold increased risk, whereas alcohol use was associated with a twofold increased risk of SPMADT.
  
  
  CONCLUSIONS
  The rates of SPMADT after treatment of SCCOC and SCCL are comparable, but the patterns are different. Smoking and alcohol use are independent predictors of SPMADT development.
authors.affiliation: Head and Neck Service, Department of Surgery, P. O. Box 285, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Lin
authors.forename: Snehal G
authors.initials: SG
authors.lastname: Patel
authors.forename: Pen Yuan
authors.initials: PY
authors.lastname: Chu
authors.forename: Jeannette M S
authors.initials: JM
authors.lastname: Matsuo
authors.forename: Bhuvanesh
authors.initials: B
authors.lastname: Singh
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Wong
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Kraus
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Shaha
authors.forename: Jatin P
authors.initials: JP
authors.lastname: Shah
authors.forename: Jay O
authors.initials: JO
authors.lastname: Boyle
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000473:pathology; D009518:New York / Q000453:epidemiology; D012907:Smoking / Q000009:adverse effects; D016019:Survival Analysis