title: Fluid-structure interaction in abdominal aortic aneurysms: effects of asymmetry and wall thickness.
abstract: BACKGROUND
  Abdominal aortic aneurysm (AAA) is a prevalent disease which is of significant concern because of the morbidity associated with the continuing expansion of the abdominal aorta and its ultimate rupture. The transient interaction between blood flow and the wall contributes to wall stress which, if it exceeds the failure strength of the dilated arterial wall, will lead to aneurysm rupture. Utilizing a computational approach, the biomechanical environment of virtual AAAs can be evaluated to study the affects of asymmetry and wall thickness on this stress, two parameters that contribute to increased risk of aneurysm rupture.
  
  
  METHODS
  Ten virtual aneurysm models were created with five different asymmetry parameters ranging from beta = 0.2 to 1.0 and either a uniform or variable wall thickness to study the flow and wall dynamics by means of fully coupled fluid-structure interaction (FSI) analyses. The AAA wall was designed to have a (i) uniform 1.5 mm thickness or (ii) variable thickness ranging from 0.5-1.5 mm extruded normally from the boundary surface of the lumen. These models were meshed with linear hexahedral elements, imported into a commercial finite element code and analyzed under transient flow conditions. The method proposed was then compared with traditional computational solid stress techniques on the basis of peak wall stress predictions and cost of computational effort.
  
  
  RESULTS
  The results provide quantitative predictions of flow patterns and wall mechanics as well as the effects of aneurysm asymmetry and wall thickness heterogeneity on the estimation of peak wall stress. These parameters affect the magnitude and distribution of Von Mises stresses; varying wall thickness increases the maximum Von Mises stress by 4 times its uniform thickness counterpart. A pre-peak systole retrograde flow was observed in the AAA sac for all models, which is due to the elastic energy stored in the compliant arterial wall and the expansion force of the artery during systole.
  
  
  CONCLUSIONS
  Both wall thickness and geometry asymmetry affect the stress exhibited by a virtual AAA. Our results suggest that an asymmetric AAA with regional variations in wall thickness would be exposed to higher mechanical stresses and an increased risk of rupture than a more fusiform AAA with uniform wall thickness. Therefore, it is important to accurately reproduce vessel geometry and wall thickness in computational predictions of AAA biomechanics.
authors.affiliation: Biomedical Engineering Department, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. cscotti@andrew.cmu.edu
authors.forename: Christine M
authors.initials: CM
authors.lastname: Scotti
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Shkolnik
authors.forename: Satish C
authors.initials: SC
authors.lastname: Muluk
authors.forename: Ender A
authors.initials: EA
authors.lastname: Finol
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology* / Q000503:physiopathology*; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology* / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical