title: Halogenated helianane derivatives from the sponge Spirastrella hartmani.
abstract: Two new halogenated derivatives (1 and 2) of helianane (3) were isolated from the 2-propanol extract of the sponge Spirastrella hartmani. The structures of the new derivatives were determined on the basis of detailed spectroscopic analysis, including (+)-HREIMS and 1D and 2D NMR. Compound 1 showed in vitro cytotoxicity against the human tumor cell lines A549, HT29, and MDA-MB-231.
authors.affiliation: Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770 Colmenar Viejo, Madrid, Spain.
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Martín
authors.forename: Fabrice
authors.initials: F
authors.lastname: Berrué
authors.forename: Philippe
authors.initials: P
authors.lastname: Amade
authors.forename: Rogelio
authors.initials: R
authors.lastname: Fernández
authors.forename: Andrés
authors.initials: A
authors.lastname: Francesch
authors.forename: Fernando
authors.initials: F
authors.lastname: Reyes
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; C505682:helianane