Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease.
There is now compelling evidence that proteinases and oxidative stress play pathogenetic roles in the following pathologies in chronic obstructive pulmonary disease: airspace enlargement; chronic inflammation in the airways, lung interstitium, and alveolar space; and mucus hypersecretion in the large airways. Proteinases and oxidants may also contribute to remodeling processes in the small airways. In addition, data are emerging that show interactions between classes of proteinases and between proteinases and oxidants, which amplify lung inflammation and injury in chronic obstructive pulmonary disease. This review discusses the biologic roles of proteinases and oxidants, their roles in the pathogenesis of chronic obstructive pulmonary disease, and their potential as targets for therapy.
Owen
Caroline A
CA
Division of Pulmonary and Critical Care Medicine, 905 Thorn Building, Brigham and Women's Hospital, Boston, MA 02115, USA. cowen@rics.bwh.harvard.edu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D016877:Oxidants / Q000502:physiology*; D018384:Oxidative Stress; D010447:Peptide Hydrolases / Q000502:physiology*; D011480:Protease Inhibitors / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016877:Oxidants; D011480:Protease Inhibitors; D010447:Peptide Hydrolases