title: [DNA-chips in the diagnosis of hematological malignancies].
abstract: In hematological malignancies, gene expression profiling using DNA-microarrays led to the discovery of novel lymphoma and leukemia subgroups. The heterogeneous entity of diffuse large B-cell lymphoma could be subdivided into the germinal center B-cell-like and the activated B-cell-like subtype which differ in pathogenesis and clinical behavior. In leukemia, existing entities defined by morphological, cytogenetic, molecular and immunophenotypic criteria were confirmed on the global gene expression level; in addition, new important molecular subgroups could be identified. In retrospective clinical lymphoma and leukemia studies, robust gene expression signatures were discovered that predict the clinical course at the time of diagnosis. Given the huge potential of the DNA-microarray technology, application in the routine diagnostic setting appears possible.
authors.affiliation: Medizinische Klinik III, Klinikum Grosshadern der Ludwig-Maximilians-Universität München.
authors.forename: M
authors.initials: M
authors.lastname: Feuring-Buske
authors.forename: E M
authors.initials: EM
authors.lastname: Hartmann
authors.forename: G
authors.initials: G
authors.lastname: Ott
authors.forename: H
authors.initials: H
authors.lastname: Reuter
authors.forename: C
authors.initials: C
authors.lastname: Buske
authors.forename: A
authors.initials: A
authors.lastname: Rosenwald
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000378:metabolism*; D008223:Lymphoma / Q000175:diagnosis* / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000032:analysis*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods* / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins