KAI1/CD82, a tumor metastasis suppressor.
Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these motility-related proteins to inhibit cell migration. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin.
Liu
Wei M
WM
Vascular Biology Center and Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Zhang
Xin A
XA
D000818:Animals; D002465:Cell Movement; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D051861:Kangai-1 Protein / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009369:Neoplasms / Q000517:prevention & control; D025521:Tumor Suppressor Proteins / Q000502:physiology*
C497688:CD82 protein, human; C497689:Cd82 antigen, mouse; C497690:Cd82 protein, rat; D051861:Kangai-1 Protein; D025521:Tumor Suppressor Proteins