title: [Effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch].
abstract: OBJECTIVE
  To study the effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch.
  
  
  METHODS
  We firstly established the experimental method of transdermal penetration, and the methodology study was carried out at the same time. Furthermore, we added 5% Azone, 10% Oleic acid, 1% PG + 4% Azone, 2% PG + 8% Oleic acid into the patch. The cumulative penetration amounts were determined during the test of transdermal penetration and the part lagged in the skin was determined after the test.
  
  
  RESULTS
  The cumulative penetration amounts released from the patch increased, while the part lagged in the skin decreased at the same time.
  
  
  CONCLUSIONS
  The results indicate that penetration enhancers can facilitate drug through corneum into dermis, but can't enhance the drug' s accumulation in the corneum. It is concluded that penetration enhancers can destroy the two-molecule structure of liposomes and cause drug leakage, so penetration enhancers should not be added into liposome patch of part functions.
authors.affiliation: Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Liling
authors.initials: L
authors.lastname: Zhou
authors.forename: Jiajun
authors.initials: J
authors.lastname: Ling
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001381:Azepines / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D008081:Liposomes; D008297:Male; D029583:Menispermaceae / Q000737:chemistry*; D009019:Morphinans / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019301:Oleic Acid / Q000008:administration & dosage / Q000494:pharmacology; D019946:Propylene Glycol / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011923:Rats, Nude; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D001381:Azepines; D008081:Liposomes; D009019:Morphinans; D019301:Oleic Acid; C009271:sinomenine; D019946:Propylene Glycol