title: Stereoselective synthesis and anti-inflammatory activities of 6- and 7-membered dioxacycloalkanes.
abstract: A class of 5-trifluoroacetylamino-1,3-dioxacycloalkanes, 5-benzoylamino-1,3-dioxacycloalkanes, and 5-amino-1,3-dioxacycloalkane compounds were stereoselectively synthesized as potential anti-inflammatory drug candidates. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model, from which multiple compounds possessing anti-inflammatory properties which surpass aspirin were identified; these compounds were then compared to establish structure-activity relationships.
authors.affiliation: College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing, PR China.
authors.forename: Keli
authors.initials: K
authors.lastname: Gu
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Cheryl
authors.initials: C
authors.lastname: Dolan
authors.forename: Michael C
authors.initials: MC
authors.lastname: Kao
authors.forename: Jeffrey B-H
authors.initials: JB
authors.lastname: Tok
authors.forename: Shiqi
authors.initials: S
authors.lastname: Peng
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000494:pharmacology; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014992:Xylenes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003516:Cycloparaffins; D014992:Xylenes; D001241:Aspirin