Laboratory study to investigate the efficacy of cyfluthrin EW treated nets against phlebotomine sandflies.
Toxic and feeding inhibition effect of cyfluthrin treated nets was assessed and compared with the activity of deltamethrin impregnated nets, before and after 2 and 4 washes against Phlebotomus papatasi. Impregnated cyfluthrin nets (50, 25, 12.5 mg active ingredient (a.i.)/m2) caused knock down and mortality rates higher than 90%, being of 100% at the highest dose, while the nets impregnated with deltamethrin (25, 12.5, 6.25 mg a.i./m2) showed low mortality rates (13.3-43.5%). Also after washing cyfluthrin at the dose of 50 mg a.i./m2 provided higher activity than deltamethrin (25 mg a.i./m2), being mortality rates within 24 hs of 66.7 and 48.9% for cyfluthrin and 38.0 and 2.1% for deltamethrin, respectively after 2 and 4 washes. Before washing, cyfluthrin (50 mg a.i./m2) significantly prevented blood feeding, with respect to both untreated (88.6%) and deltamethrin impregnated nets (56.8%). Deltamethrin (25 mg a.i./m2) showed low feeding inhibition (48.4%), although it was significantly higher than control. The washing of cyfluthrin impregnated nets (50 mg a.i./m2) produced a decrease of the feeding inhibition, being the reduction of 26.6% and 41.3%, respectively after 2 and 4 washes. Two washes of deltamethrin impregnated nets (25 mg a.i./m2) yielded a very high reduction of antifeeding inhibition (68.8%). These laboratory results if confirmed by field evaluation indicate cyfluthrin as good candidate for treatment of mosquito nets to be used against phlebotomine sandflies.
Bongiorno
Gioia
G
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy.
Panchetti
Fabiana
F
Zaim
Morteza
M
Maroli
Michele
M
D000818:Animals; D001512:Bedding and Linens; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006801:Humans; D007300:Insect Control / Q000295:instrumentation* / Q000379:methods; D007303:Insect Vectors / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology; D007896:Leishmaniasis / Q000517:prevention & control / Q000635:transmission; D009570:Nitriles / Q000494:pharmacology; D010691:Phlebotomus / Q000187:drug effects; D011722:Pyrethrins / Q000494:pharmacology; D012995:Solubility; D014867:Water
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014867:Water; C017180:decamethrin; C052570:cyfluthrin