title: [Fetus and magnesium].
abstract: Chronic magnesium deficiency in pregnant women is frequently seen because of inadequate or low intake of magnesium. Magnesium deficiency during pregnancy can induce not only maternal and fetal nutritional problem, but also pediatric consequences that might last throughout life. Many epidemiological studies have disclosed that restricted fetal growth, i.e., intrauterine growth retardation (IUGR) is associated with an increased risk of insulin resistance in adult life. We previously postulated that intracellular magnesium of cord blood platelets is lower in the small for gestational age than in the appropriate for gestational age group, suggesting chronic intrauterine magnesium deficiency may result in IUGR. Taken together, chronic intrauterine magnesium deficiency in the fetus may lead to or program the insulin resistance after birth. Prospective study whether the children born with magnesium induced IUGR are at high-risk for metabolic syndrome in childhood or adulthood is currently undertaken.
authors.affiliation: Department of Pediatrics, Kansai Medical University.
authors.forename: Junji
authors.initials: J
authors.lastname: Takaya
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D008274:Magnesium / Q000502:physiology*; D008275:Magnesium Deficiency / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications
chemical_list: D008274:Magnesium