Plasmodium permeomics: membrane transport proteins in the malaria parasite.
Membrane transport proteins are integral membrane proteins that mediate the passage across the membrane bilayer of specific molecules and/or ions. Such proteins serve a diverse range of physiological roles, mediating the uptake of nutrients into cells, the removal of metabolic wastes and xenobiotics (including drugs), and the generation and maintenance of transmembrane electrochemical gradients. In this chapter we review the present state of knowledge of the membrane transport mechanisms underlying the cell physiology of the intraerythrocytic malaria parasite and its host cell, considering in particular physiological measurements on the parasite and parasitized erythrocyte, the annotation of transport proteins in the Plasmodium genome, and molecular methods used to analyze transport protein function.
Kirk
K
K
School of Biochemistry and Molecular Biology, The Australian National University, 0200 Canberra, ACT, Australia. Kiaran.Kirk@anu.edu.au
Martin
R E
RE
Bröer
S
S
Howitt
S M
SM
Saliba
K J
KJ
D000818:Animals; D001692:Biological Transport / Q000235:genetics; D002462:Cell Membrane / Q000502:physiology; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000469:parasitology*; D017125:Genes, Protozoan; D007425:Intracellular Membranes / Q000502:physiology; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010539:Permeability; D010961:Plasmodium / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D026901:Membrane Transport Proteins; D015800:Protozoan Proteins