Development of a biosensor for measuring plasma fibrinogen based on an enzyme kinetic model.
A biosensor has been designed for measuring plasma fibrinogen concentrations based on an enzyme kinetic model. The values obtained correspond linearly to those of a clinical method but have a higher sensitivity within the normal range of fibrinogen. By using the disposable biosensor technology, this method is easy to follow, quick (within 2 min) and precise (with coefficients of variation to be as low as below 5%) and requires only a small amount of plasma sample (<50 microl). This biosensor technology also holds potential for use in point-of-care diagnostics.
Yang
Zhen
Z
College of Life Sciences, Shenzhen University, 518060, Shenzhen, China. zyang@szu.edu.cn
Zhou
Dao Min
DM
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D010949:Plasma / Q000737:chemistry*; D012680:Sensitivity and Specificity
D005340:Fibrinogen