Nonlinear photodynamic therapy: method of pulsed oxygen depletion.
The photodynamic therapy technique involving pulsed oxygen depletion (POD) in tissue by long high-energy pulses of light was studied theoretically. The possibility of creating a uniform distribution of a therapeutic dose throughout a tumor using both surface and interstitial irradiation is shown. Possible thickness of the treated tissue layer is estimated. The comparison with other methods of nonlinear photodynamic therapy is made.
Kogan
Boris Ya
BY
Organic Intermediates and Dyes Institute, B. Sadovaya str. 1/4, 123995 Moscow, Russia. bkogan@mail.mipt.ru
D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D008027:Light; D008962:Models, Theoretical; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism*; D010101:Oxygen Consumption / Q000528:radiation effects; D010777:Photochemistry; D010778:Photochemotherapy / Q000379:methods*
D010100:Oxygen