title: Characterization and biological activities of two copper(II) complexes with diethylenetriamine and 2,2'-bipyridine or 1,10-phenanthroline as ligands.
abstract: Two new mixed ligand copper(II) complexes with diethylenetriamine, 2,2'-bipyridine and 1,10-phenanthroline have been synthesized. The crystal and molecular structures of [Cu(dien)(phen)](ClO(4))(2) and [Cu(dien)(bipy)](BF(4))(2) (dien=diethylenetriamine, phen=1,10-phenanthroline, bipy=2,2'-bipyridine) were determined by X-ray crystallography from single crystal data. These two complexes have similar structures. The EPR spectral data also suggest that these complexes have distorted square pyramidal geometry about copper(II). Anti-microbial and superoxide dismutase activities of these complexes have also been measured. They show the higher SOD activity than the corresponding simple Cu(II)-dien/Cu(II)-PMDT (PMDT=N,N,N',N',N''-pentamethyldiethylenetriamine) complexes because of a strong axial bond of one of the nitrogen atoms of the alpha-diimine. Both the complexes have been found to cleave plasmid DNA in the presence of co-reductants such as ascorbic acid and glutathione.
authors.affiliation: Department of Chemistry, A.P.S. University, Rewa, M.P. 486003, India. rnp64@yahoo.co.uk
authors.forename: R N
authors.initials: RN
authors.lastname: Patel
authors.forename: Nripendra
authors.initials: N
authors.lastname: Singh
authors.forename: K K
authors.initials: KK
authors.lastname: Shukla
authors.forename: J
authors.initials: J
authors.lastname: Niclós-Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Castineiras
authors.forename: V G
authors.initials: VG
authors.lastname: Vaidyanathan
authors.forename: Balachandran Unni
authors.initials: BU
authors.lastname: Nair
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D004926:Escherichia coli / Q000187:drug effects; D007700:Kinetics; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology; D010957:Plasmids / Q000378:metabolism; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology; D011511:Proteus / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D008024:Ligands; D010618:Phenanthrolines; D011073:Polyamines; C005391:diethylenetriamine; D003300:Copper; D013482:Superoxide Dismutase; C025205:1,10-phenanthroline