title: Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol.
abstract: The planned MADIT-CRT trial is designed to determine if CRT-D will reduce the risk of mortality and HF events by approximately 25% in subjects with ischemic (NYHA class I-II) and non-ischemic (NYHA class II) cardiomyopathy, left ventricular dysfunction (EF<or=0.30), and prolonged intraventricular conduction (QRS duration>or=130 ms).
authors.affiliation: Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. heartajm@heart.rochester.edu
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Moss
authors.forename: Mary W
authors.initials: MW
authors.lastname: Brown
authors.forename: David S
authors.initials: DS
authors.lastname: Cannom
authors.forename: James P
authors.initials: JP
authors.lastname: Daubert
authors.forename: Mark
authors.initials: M
authors.lastname: Estes
authors.forename: Elyse
authors.initials: E
authors.lastname: Foster
authors.forename: Henry M
authors.initials: HM
authors.lastname: Greenberg
authors.forename: W Jackson
authors.initials: WJ
authors.lastname: Hall
authors.forename: Steven L
authors.initials: SL
authors.lastname: Higgins
authors.forename: Helmut
authors.initials: H
authors.lastname: Klein
authors.forename: Mark
authors.initials: M
authors.lastname: Pfeffer
authors.forename: David
authors.initials: D
authors.lastname: Wilber
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zareba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial / Q000706:statistics & numerical data*; D015897:Comorbidity; D017147:Defibrillators, Implantable / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000628:therapy*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology / Q000628:therapy*