Electrochemical study of natamycin--analytical application to pharmaceutical dosage forms by differential pulse voltammetry.
The electrochemical oxidation and determination of natamycin has been carried out at a carbon paste electrode in aqueous solutions in the pH range of 2.5-10.30 by cyclic and differential pulse voltammetry. Best results were obtained with the differential pulse voltammetric technique in 0.5 M sulfuric acid at pH 1.82. The diffusion controlled nature of the waves was established. A differential pulse voltammetric technique for the determination of natamycin 0.5 M sulfuric acid which allows quantitation over the range of 2 x 10(-6)-8 x 10(-5) M range method is proposed. Limit of detection and limit of quantitatification were 1.5 x 10(-6) and 5 x 10(-6) M, respectively. Based on this study a simple, rapid, selective and sensitive voltammetric method was developed for the determination of natamycin in capsules. In order to validate the proposed method, UV spectroscopy was applied.
Aki
C
C
Department of Molecular Biology, Faculty of Arts and Sciences, University of Canakkale Onsekiz Mart, Canakkale, Turkey.
Yilmaz
S
S
Dilgin
Y
Y
Yagmur
S
S
Suren
E
E
D000935:Antifungal Agents / Q000737:chemistry*; D002138:Calibration; D002214:Capsules; D004304:Dosage Forms; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D010866:Natamycin / Q000737:chemistry*; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000935:Antifungal Agents; D002214:Capsules; D004304:Dosage Forms; D007202:Indicators and Reagents; D013607:Tablets; D010866:Natamycin