Receptors, G proteins, and their interactions.
Membrane receptors coupling to intracellular G proteins (G protein-coupled receptors) form one of the major classes of membrane signaling proteins. They are of great importance to the practice of anesthesiology because they are involved in many systems of relevance to the specialty (cardiovascular and respiratory control, pain transmission, and others) and many drugs target these systems. In recent years, understanding of these signaling systems has grown. The structure of receptors and G proteins has been elucidated in more detail, their regulation is better understood, and the complexity of interactions between the various parts of the system (receptors, G proteins, effectors, and regulatory molecules) has become clear. These findings may help explain both actions and side effects of drugs. In addition, these newly discovered targets are likely to play important roles in disease states of relevance to anesthesiologists.
Hollmann
Markus W
MW
Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908-0710, USA.
Strumper
Danja
D
Herroeder
Susanne
S
Durieux
Marcel E
ME
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D000777:Anesthetics; D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins