title: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.
abstract: The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p < or = 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p < or = 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).
authors.affiliation: Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy. b.bocca@iss.it
authors.forename: Beatrice
authors.initials: B
authors.lastname: Bocca
authors.forename: Giovanni
authors.initials: G
authors.lastname: Forte
authors.forename: Francesco
authors.initials: F
authors.lastname: Petrucci
authors.forename: Anna
authors.initials: A
authors.lastname: Pino
authors.forename: Francesca
authors.initials: F
authors.lastname: Marchione
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bomboi
authors.forename: Oreste
authors.initials: O
authors.lastname: Senofonte
authors.forename: Franco
authors.initials: F
authors.lastname: Giubilei
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000209:etiology; D015415:Biomarkers; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000009:adverse effects / Q000097:blood*; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012825:Silicon / Q000097:blood; D013048:Specimen Handling
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; D008670:Metals; D016877:Oxidants; D006861:Hydrogen Peroxide; D012825:Silicon