Homo and heterodimers of ddI, d4T and AZT: influence of (5'-5') thiolcabonate-carbamate linkage on anti-HIV activity.
New homo and heterodimers of ddI, d4T and AZT with (5-5) thiolcarbonate-carbamate linkages have been prepared with the aim of testing them against wild type and NNRTI resistant HIV mutants. The prepared dimers showed a low activity in comparison to the parent drug.
Taourirte
M
M
Faculty of Sciences and Techniques, Marrakech, Morocco.
Lazrek
H B
HB
Rochdi
A
A
Vasseur
J J
JJ
Engels
J W
JW
D019380:Anti-HIV Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002219:Carbamates / Q000737:chemistry*; D016049:Didanosine / Q000737:chemistry*; D019281:Dimerization; D006678:HIV / Q000235:genetics / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy; D008956:Models, Chemical; D008968:Molecular Conformation; D009154:Mutation; D018119:Stavudine / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D015215:Zidovudine / Q000737:chemistry*
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D002219:Carbamates; D013438:Sulfhydryl Compounds; D015215:Zidovudine; D018119:Stavudine; D016049:Didanosine