title: Catheter-associated recurrent intracardiac thrombosis and factor V Leiden mutation in a child with non-Hodgkin's lymphoma.
abstract: Patients with cancer have an increased risk for thromboembolism, which might be related to several factors including central venous catheters and chemotherapeutics. Congenital prothrombotic risk factors might also contribute to thrombotic events. In this report, we present a catheter-related recurrent intracardiac thrombosis in a boy with non-Hodgkin's lymphoma and factor V Leiden mutation. Screening for factor V Leiden mutation in children with cancer and recurrent thrombotic events is recommended. Periodic echocardiography may be considered for a group of patients if the catheter tip is in the right atrium and therapy includes L-asparaginase and corticosteroids.
authors.affiliation: Department of Pediatrics, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Corapçioğlu
authors.forename: Kamer Mutafoğlu
authors.initials: KM
authors.lastname: Uysal
authors.forename: Erdem
authors.initials: E
authors.lastname: Silistreli
authors.forename: Nurettin
authors.initials: N
authors.lastname: Unal
authors.forename: Hale
authors.initials: H
authors.lastname: Oren
authors.forename: Unal
authors.initials: U
authors.lastname: Açikel
mesh_terms: D002408:Catheters, Indwelling / Q000009:adverse effects*; D002648:Child; D005165:Factor V / Q000235:genetics*; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D012008:Recurrence; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D014463:Ultrasonography
chemical_list: C095381:factor V Leiden; D005165:Factor V