[The efficacy and safety of trazodone in the treatment of adjustment disorders--naturalistic research].
There are a great number of traumatic and stressful events that people are exposed to in the contemporary world. The response to them is the subjectively felt stress and numerous emotional reactions with anxiety and lowering of the mood. These symptoms substantially limit the ability of social and vocational performance. Their appearance allow to diagnose adjustment disorders.


OBJECTIVE
The evaluation of therapeutic efficiency and safety of using trazodone in treatment of adjustment disorders with the particular focus on dominant symptoms in this illness that is anxiety, lowering of the mood, low self-esteem, sleep disorders and also aggression level.


METHODS
52 people of both sexes participated in this study. They were diagnosed with adjustment disorders and underwent some treatment in psychiatric surgery. The completed Hamilton's Depressive Scale and Anxiety Symptoms Scale COVI. Clinical condition of the patients was examined with Clinical General Impression Scale. The level of self-Acceptance was measured with ACL test. The examination lasted 56 days.


RESULTS
Post hoc statistical tests allowed to form the idea that in the case of depression the intensity of the symptoms decreased significantly on the 14th day of the therapy. However, the anxiety symptoms decreased dramatically on the 7th day.


CONCLUSIONS
(1). Trazodone turned out to be an efficacious medicine in the therapy of adjustment disorders. On the 56th day of the study the illness of 65.4% of patients was in remission, 26.9% of them responded to treatment, and 7.7% of them didn't. (2). Trazodone on the 7th day of therapy diminishes considerably the anxiety intensity and sleep disorder, and on the 14th day of the therapy it has an antidepressive effect. (3). As result of treating patients with trazodone the level of self-acceptance measured by ACL test has increased.
Gałecki
Piotr
P
Klinika Psychiatrii i Zaburzeń Nerwicowych z Oddziałem Interwencji Kryzysowych Uniwersytetu Medycznego, Lodzi. galeckipiotr@o2.pl
Zboralski
Krzysztof
K
Florkowski
Antoni
A
D000275:Adjustment Disorders / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D000339:Affect / Q000187:drug effects; D000374:Aggression; D001007:Anxiety / Q000209:etiology / Q000517:prevention & control; D003863:Depression / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012649:Self Concept; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012893:Sleep Wake Disorders / Q000209:etiology / Q000517:prevention & control; D014196:Trazodone / Q000494:pharmacology*; D016896:Treatment Outcome
D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone