The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes.
The intestinal fatty-acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] <20 microg/min; n = 529), microalbuminuria (UAE 20-199 microg/min; n = 217), or proteinuria (UAE >199 microg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1-5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0-7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients.
Canani
Luis H
LH
Endocrine Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Capp
Clarissa
C
Ng
Daniel P K
DP
Choo
Serena G L
SG
Maia
Ana Luiza
AL
Nabinger
Gustavo B
GB
Santos
Kátia
K
Crispim
Daisy
D
Roisemberg
Israel
I
Krolewski
Andrzej S
AS
Gross
Jorge L
JL
D001938:Brazil; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000150:complications* / Q000235:genetics*; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008404:Massachusetts; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*
C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins