title: Microwave irradiation for accelerating the synthesis of acyclonucleosides of 1,2,4-triazole.
abstract: The 3-(D-alditol-1-yl)-4-amino-5-mercapto-1,2,4-triazoles 4 and 5 can be successfully prepared using microwave irradiation. Condensation of 4 and 5 with p-nitrobenzaldehyde afforded Schiff bases 6 and 7, respectively. Reaction 4 and 5 with ethylchloroacetate gave the corresponding alkylated products 10 and 11. Better yields and much less time were the characteristic features of using the microwave heating over the conventional one. The structure of the prepared compounds was confirmed by 1H-NMR, 2D-NMR and mass spectra.
authors.affiliation: Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt. eelashry60@link.net
authors.forename: E S H
authors.initials: ES
authors.lastname: El Ashry
authors.forename: L F
authors.initials: LF
authors.lastname: Awad
authors.forename: H M
authors.initials: HM
authors.lastname: Abdel Hamid
authors.forename: A I
authors.initials: AI
authors.lastname: Atta
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis*; D012545:Schiff Bases; D013997:Time Factors; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009705:Nucleosides; D012545:Schiff Bases; D014230:Triazoles; C045575:1,2,4-triazole