title: Invasive chromoblastomycosis and sinusitis due to Phialophora verrucosa in a child from northern Africa.
abstract: We report on a severe, verrucous facial mycosis and sinusitis in a 12-year-old Libyan girl. Her disease started with verrucous, hyperkeratotic plaques and subcutaneous violet nodules of unknown origin on her face and upper extremities. Despite topical antimycotic therapy she needed in-hospital treatment because of severely progressive tumorous cutaneous and nasal lesions. Microscopic examination of scale samples taken from the upper extremities and the face revealed brown, thick-walled fungal elements. Under the assumption of a chromoblastomycosis, an oral treatment with itraconazole and fluorocytosin was initiated, with significant improvement of the lesions. The aetiological agent was identified as Phialophora verrucosa.
authors.forename: H
authors.initials: H
authors.lastname: Hofmann
authors.forename: S-M
authors.initials: SM
authors.lastname: Choi
authors.forename: D
authors.initials: D
authors.lastname: Wilsmann-Theis
authors.forename: R
authors.initials: R
authors.lastname: Horré
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
authors.forename: T
authors.initials: T
authors.lastname: Bieber
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002862:Chromoblastomycosis / Q000382:microbiology* / Q000473:pathology*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005145:Face / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008002:Libya; D010676:Phialophora / Q000166:cytology / Q000302:isolation & purification*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012852:Sinusitis / Q000382:microbiology* / Q000473:pathology; D034941:Upper Extremity / Q000382:microbiology / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D017964:Itraconazole