title: More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines.
abstract: Despite recent advances in antibiotic therapy and intensive care, sepsis remains widespread problems in critically ill patients. The high mortality of sepsis is in part mediated by bacterial endotoxin, which stimulates macrophages/monocytes to sequentially release early (e.g., TNF, IL-1, and IFN-gamma) and late (e.g., HMGB1) pro-inflammatory cytokines. In light of our recent discovery of HMGB1 as a late mediator of lethal systemic inflammation, and the observation that green tea (Camellia sinensis) dose-dependently attenuated bacterial endotoxin-induced HMGB1 release, we propose that regular tea intake might decrease the incidence of and mortality rates from lethal endotoxemia and sepsis.
authors.affiliation: Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Haichao
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015153:Blotting, Western; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D019446:Endotoxemia / Q000378:metabolism / Q000473:pathology; D004731:Endotoxins / Q000378:metabolism*; D024243:HMGB1 Protein / Q000378:metabolism; D007249:Inflammation; D051379:Mice; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology*; D013662:Tea; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D004731:Endotoxins; D024243:HMGB1 Protein; D013662:Tea