Preparation of 4-pentenoic acid ester of Neu5Ac and 4-pentenyl glycoside of Neu5Ac and their application to glycosylation.
Novel sialosyl donors, 4-pentenoic acid ester of N-acetylneuraminic acids (Neu5Ac) and 4-pentenyl glycoside of Neu5Ac were successfully prepared from the corresponding per-O-acetylated 2-hydroxy and 2-chloro derivatives of Neu5Ac, respectively and applied to the synthesis of O-sialosides.
Ikeda
Kiyoshi
K
School of Pharmaceutical Sciences, University of Shizuoka, Japan. ikeda@u-shizuoka-ken.ac.jp
Fukuyo
Jun
J
Sato
Kazuki
K
Sato
Masayuki
M
D002240:Carbohydrate Sequence; D004987:Ethers; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry; D006031:Glycosylation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004987:Ethers; D006027:Glycosides; D007202:Indicators and Reagents; D012997:Solvents; D019158:N-Acetylneuraminic Acid