title: Diminazene aceturate resistance on the virulence of Trypanosoma brucei for rats.
abstract: Four groups (A, B, C and D) of 10 naïve rats were used to compare the virulence of isolates of a strain of Trypanosoma brucei before and after the development of diminazene aceturate resistance. Group A rats were uninfected (controls). Group B rats were infected with a trypanosome isolate unexposed to the drug, while groups C and D rats were infected with two different drug-resistant isolates of the same strain. Rats in the three infected groups each received 10(6) trypanosomes intraperitoneally. Prepatent periods were longer (P<0.05) in groups C and D than in group B. The parasitaemic periods in groups B, C and D were similar, but group C and D rats differed from group B rats in surviving longer, and in showing lower degrees of parasitaemia, anaemia and hepatomegaly. No differences were noted between group C and D rats. Thus, diminazene aceturate resistance appeared to reduce the virulence of T. brucei.
authors.affiliation: Department of Veterinary Physiology and Pharmacology, University of Maiduguri, P.M.B. 1069, Maiduguri, Borno State, Nigeria.
authors.forename: T N
authors.initials: TN
authors.lastname: Egbe-Nwiyi
authors.forename: I O
authors.initials: IO
authors.lastname: Igbokwe
authors.forename: P A
authors.initials: PA
authors.lastname: Onyeyili
mesh_terms: D000818:Animals; D004133:Diminazene / Q000031:analogs & derivatives* / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D008297:Male; D051381:Rats; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014346:Trypanosoma brucei brucei / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D014352:Trypanosomiasis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D014774:Virulence / Q000187:drug effects
chemical_list: D014344:Trypanocidal Agents; C003915:diminazene aceturate; D004133:Diminazene