Advances in short bowel syndrome: an updated review.
Short bowel syndrome (SBS) continues to be an important clinical problem due to its high mortality and morbidity as well as its devastating socioeconomic effects. The past 3 years have witnessed many advances in the investigation of this condition, with the aim of elucidating the cellular and molecular mechanisms of intestinal adaptation. Such information may provide opportunities to exploit various factors that act as growth agents for the remaining bowel mucosa and may suggest new therapeutic strategies to maintain gut integrity, eliminate dependence on total parenteral nutrition, and avoid the need for intestinal transplantation. This review summarizes current research on SBS over the last few years.
Sukhotnik
Igor
I
Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb Street, P.O.B. 4940, Haifa, 31048 Israel. igor-dr@internet-zahav.net
Coran
Arnold G
AG
Kramer
Alexander
A
Shiloni
Eitan
E
Mogilner
Jorge G
JG
D000220:Adaptation, Biological; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007413:Intestinal Mucosa / Q000637:transplantation; D007422:Intestines / Q000503:physiopathology; D017093:Liver Failure / Q000209:etiology; D018805:Sepsis / Q000209:etiology; D012778:Short Bowel Syndrome / Q000150:complications / Q000503:physiopathology / Q000628:therapy