title: Protein components for nanodevices.
abstract: A long-term goal of nanobiotechnology is to build tiny devices that respond to the environment, perform computations and carry out tasks. Considerable progress has been made in building protein components for such devices, and here we describe examples, including self-assembling protein arrays, pores with triggers and switches, and motor proteins harnessed for specific tasks. A major issue that has been successfully addressed in this recent work is the interface between the proteins and other components of the system, such as a metal surface. While further progress is expected in the coming years, the assembly of devices from the components has seen more limited accomplishments. For example, although a wide variety of sensors based on nanobiotechnology has been developed, unresolved problems still confront the construction of complex nanobioelectronic circuits, and the development of nanorobotics with biological components remains a distant dream.
authors.affiliation: Department of Chemistry, University of Oxford, OX1 3TA, England, UK.
authors.forename: Yann
authors.initials: Y
authors.lastname: Astier
authors.forename: Hagan
authors.initials: H
authors.lastname: Bayley
authors.forename: Stefan
authors.initials: S
authors.lastname: Howorka
mesh_terms: D046208:Microchip Analytical Procedures; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D040081:Protein Array Analysis; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
chemical_list: D020409:Molecular Motor Proteins; D011506:Proteins