title: Reversal reaction and Mitsuda conversion in polar lepromatous leprosy: a case report.
abstract: A 22-year-old male polar lepromatous leprosy patient who became Mitsuda positive after 36 months of multidrug therapy (MDT) is reported. Lepromatous leprosy (LL) is a state of specific immunosuppression and is invariably irreversible. The finding of Mitsuda positivity in histopathologically proven polar lepromatous leprosy is extremely uncommon, and conversion of lepromin status following MDT has not so far been reported. This case reports confirms the observations made by Waters et al. regarding lepromin conversion in lepromatous patients.
authors.affiliation: Department of Dermatology, SLR & TC, Karigiri, Vellore, India. karbikash@hotmail.com
authors.forename: Bikash Ranjan
authors.initials: BR
authors.lastname: Kar
authors.forename: C K
authors.initials: CK
authors.lastname: Job
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D006801:Humans; D016867:Immunocompromised Host; D007916:Lepromin / Q000276:immunology*; D007917:Leprostatic Agents / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000188:drug therapy / Q000276:immunology*; D008297:Male
chemical_list: D007917:Leprostatic Agents; D007916:Lepromin