title: Steroidal glycosides from Cynanchum forrestii Schlechter.
abstract: Nine new steroidal glycosides, cynaforrosides B, C, D, E, and F, based on a 13, 14: 14, 15-disecopregnane-type skeleton, cynaforrosides G, H, and I with a new aglycone named cynaforrogenin A, and cynaforroside J together with three known C21 steroidal glycosides cynatratoside A, hancoside and komaroside C were isolated from the ethanol extract of the roots of Cynanchum forrestii Schlechter. The structures of new compounds were determined on the basis of spectral and chemical evidence. Steroidal glycosides with three kinds of skeletons were isolated from this plant simultaneously. The sugar units of cynaforrosides B-I contained two moieties of glucoses and especially cynaforrosides E-I contained two glucoses with the mode of 1-->6 linkage, which were rare among steroidal glycosides of the genus Cynanchum.
authors.affiliation: Key Laboratory of Bioactive Substances, Ministry of Education, Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.forename: Youcai
authors.initials: Y
authors.lastname: Hu
authors.forename: Shishan
authors.initials: S
authors.lastname: Yu
authors.forename: Guangmiao
authors.initials: G
authors.lastname: Fu
authors.forename: Xiangzhong
authors.initials: X
authors.lastname: Huang
authors.forename: Lihua
authors.initials: L
authors.lastname: Fan
mesh_terms: D029062:Apocynaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D008279:Magnetic Resonance Imaging; D018517:Plant Roots / Q000737:chemistry; D013256:Steroids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D007166:Immunosuppressive Agents; D013256:Steroids