Distribution of strain families of Mycobacterium tuberculosis causing pulmonary and extrapulmonary disease in hospitalized children in Cape Town, South Africa.
We studied the association between strain family and extrapulmonary tuberculosis among 285 children presenting to a pediatric hospital. Extrapulmonary disease occurred in 56% of children without known human immunodeficiency virus infection, with meningitis accounting for 22% of the cases. Two strain families, LAM3/F11 and W-Beijing, predominated; but there was no overall association with extrapulmonary disease.
Nicol
Mark P
MP
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa. mnicol@curie.uct.ac.za
Sola
Christophe
C
February
Bradley
B
Rastogi
Nalin
N
Steyn
Lafras
L
Wilkinson
Robert J
RJ
D002675:Child, Preschool; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics; D012189:Retrospective Studies; D013019:South Africa; D013045:Species Specificity; D014376:Tuberculosis / Q000382:microbiology*