Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0.
Preparation and evaluation of a number of stationary phases for improved chromatographic purification of pneumocandin B0, a key intermediate in the synthesis of the antifungal agent, Cancidas, has led to the identification of several materials with potential for improved performance.
Welch
Christopher J
CJ
Merck Research Laboratories, Merck & Co. Inc., Rahway, NJ 07065, USA.
DaSilva
Jimmy O
JO
Nti-Gyabaah
Joseph
J
Antia
Firoz
F
Goklen
Kent
K
Boyd
Russell
R
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D054714:Echinocandins; D010456:Peptides, Cyclic / Q000302:isolation & purification*; D012822:Silicon Dioxide
D054714:Echinocandins; D010456:Peptides, Cyclic; C079465:pneumocandin B(0); D012822:Silicon Dioxide