title: Metals and oxidative stress in patients with Parkinson's disease.
abstract: Twenty-six metals and the oxidative status in 71 patients affected by Parkinson's disease and 44 healthy individuals were compared in order to identify potential biomarkers of the disease. In the patients, the following significant imbalances were found (p < or = 0.05): i) in serum, an increment of Ca, Mg, Ni, Si and V, and a decrement of Cd, Co, Fe, Li, Sn, Zn and Zr; ii) in blood, raised levels of Co, Li, Ni and Si and decreased of Al, Be, Ca, Cd, Fe, Mg, Mo, Sn, Zn and Zr; iii) increased formation of oxidant species and lowered anti-oxidant capacity (p < or = 0.001 for both). Barium, Bi, Cr, Cu, Hg, Mn, Pb, Sb, Sr, Tl and W did not change with the disease. The best discriminating variables between patients and controls were Cd, Co, Fe, Ni and Si in serum (91.2% of cases correctly classified), and Al, Cd, Co, Fe, Mo and Si in blood (98.2% of cases properly classified).
authors.affiliation: Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Forte
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
authors.forename: Anna
authors.initials: A
authors.lastname: Pino
authors.forename: Paolo
authors.initials: P
authors.lastname: Stanzione
authors.forename: Sonia
authors.initials: S
authors.lastname: Brescianini
authors.forename: Livia
authors.initials: L
authors.lastname: Brusa
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sancesario
authors.forename: Nicola
authors.initials: N
authors.lastname: Violante
authors.forename: Beatrice
authors.initials: B
authors.lastname: Bocca
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000009:adverse effects / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D012825:Silicon / Q000097:blood
chemical_list: D000978:Antiparkinson Agents; D008670:Metals; D012825:Silicon