Recurrent ependymoma treated with high-dose tamoxifen in a peripubertal female: Impact on tumor and the pituitary-ovarian axis.
Due to high rates of recurrence, the prognosis of childhood ependymoma remains guarded. Anecdotal evidence suggests that tamoxifen may have a role in the treatment of these tumors. We present a case of a child with recurrent ependymoma treated with tamoxifen who showed tumor regression on two separate occasions. However, treatment with tamoxifen resulted in the development of large ovarian cysts associated with supraphysiological plasma concentrations of estradiol.
Yoffe
Rona
R
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Khakoo
Yasmin
Y
Dunkel
Ira J
IJ
Souweidane
Mark
M
Lis
Eric
E
Sklar
Charles
C
D002648:Child; D004806:Ependymoma / Q000150:complications* / Q000188:drug therapy*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D010048:Ovarian Cysts / Q000139:chemically induced*; D011627:Puberty; D012008:Recurrence; D013629:Tamoxifen / Q000494:pharmacology* / Q000627:therapeutic use; D047368:Tumor Burden / Q000187:drug effects
D013629:Tamoxifen; D004958:Estradiol