title: 5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a useful rice herbicide.
abstract: 5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)-1,2-isoxazoline derivative was synthesized, and its herbicidal activity was assessed under glasshouse and flooded paddy conditions. 5-(2,6-Difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)-1,2-isoxazoline demonstrated good rice selectivity and potent herbicidal activity against annual weeds at 125 g of a.i. ha(-1) under greenhouse conditions. Soil application of this compound showed complete control of barnyard-grass to the fourth leaf stage at 250 g of a.i. ha(-1). Field trials indicated that this compound controlled annual weeds rapidly with a good tolerance on transplanted rice seedlings by post-emergence and soil application. This compound showed a low mammalian and environmental toxicity in various toxicological tests.
authors.affiliation: Korea Research Institute of Chemical Technology, Yuseong, Taejon 305-606, Korea. ithwang@krict.re.kr
authors.forename: In Taek
authors.initials: IT
authors.lastname: Hwang
authors.forename: Hyoung Rae
authors.initials: HR
authors.lastname: Kim
authors.forename: Dong Ju
authors.initials: DJ
authors.lastname: Jeon
authors.forename: Kyung Sik
authors.initials: KS
authors.lastname: Hong
authors.forename: Jong Hwan
authors.initials: JH
authors.lastname: Song
authors.forename: Kwang Yun
authors.initials: KY
authors.lastname: Cho
mesh_terms: D000818:Animals; D006540:Herbicides / Q000008:administration & dosage* / Q000633:toxicity; D007555:Isoxazoles / Q000008:administration & dosage* / Q000633:toxicity; D051379:Mice; D012275:Oryza / Q000187:drug effects / Q000254:growth & development*; D006109:Poaceae / Q000187:drug effects
chemical_list: C506359:5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline; D006540:Herbicides; D007555:Isoxazoles