Effect of benzo[a]pyrene on the immune status of mice with anxious-depressive syndrome.
We studied the effect of benzo[a]pyrene on cells of lymphoid organs, energy metabolism of blood lymphocytes, and immunological reactivity in mice with anxious depressive syndrome produced by social stress. Benzo[a]pyrene exhibited a more pronounced immunotoxic activity in anxious-depressive animals, which was more than a simple sum of the effects produced by adverse ecological and psychic factors.
Verbitskaya
L V
LV
Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Tenditnik
M V
MV
Michurina
S V
SV
Shurlygina
A V
AV
Trufakin
V A
VA
D000818:Animals; D001008:Anxiety Disorders / Q000276:immunology*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D001772:Blood Cell Count; D003866:Depressive Disorder / Q000276:immunology*; D004734:Energy Metabolism / Q000187:drug effects*; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D007109:Immunity / Q000187:drug effects*; D007150:Immunohistochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018709:Statistics, Nonparametric; D013385:Succinate Dehydrogenase / Q000378:metabolism
D001564:Benzo(a)pyrene; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase