Tryptophan hydroxylase polymorphism is associated with age of onset of alcoholism related behaviors.
The purpose of this study was to explore the association of a tryptophan hydroxylase gene polymorphism (TPH1 A218C) with the age of alcoholism onset in a Korean population. The genotype and allele frequencies of TPH1 were investigated in 182 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for alcohol dependence. Alcoholics with the TPH1 AA or AC genotypes had an earlier age of disease onset (median age of onset, 26.5 years) than those with the CC genotype (median age of onset, 30 years; p=.002). Age of onset has been used in classifying alcoholics. The TPH1 polymorphism may explain, in part, the biological basis for these typologies.
Chung
In-Won
IW
Department of Neuropsychiatry, Dongguk University International Hospital, Gyeonggi, Republic of Korea. ciw@duih.org
Kim
Heon
H
Sribney
William
W
Hong
Joo-Bong
JB
Lee
Chul-Ho
CH
Lee
Kyu-Young
KY
Nan
Hong-Mei
HM
Kim
Yong-Sik
YS
Manowitz
Paul
P
D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012907:Smoking / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D014365:Tryptophan Hydroxylase