title: Stereoselective synthesis of novel thioiso dideoxy nucleosides with exocyclic methylene as potential antiviral agents.
abstract: Novel thioiso pyrimidine and purine nucleosides substituted with exocyclic methylene have been synthesized, starting from D-xylose. Cyclization of the dimesylate to the 4-thiosugar 6a proceeded in pure SN2 reaction in the presence of allylic functional group.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: Prashantha
authors.initials: P
authors.lastname: Gunaga
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Hyun Ji
authors.initials: HJ
authors.lastname: Kim
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006838:Hydrocarbons / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D014994:Xylose / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D006838:Hydrocarbons; D009705:Nucleosides; C030011:carbene; D014994:Xylose; D008697:Methane