[Cytological basis and significance of mesenchymal stem cells differentiated into endothelial cells].
Mesenchymal stem cells (MSCs) are a multipotent population which mainly localized in the bone marrow. MSCs were also isolated from the umbilical blood, peripheral blood, fatty tissue, skin and so on. MSCs have special immunity and persist in the xenogeneic explantation which expand the clinical application. At present, the system of culturation, induction and identification of MSCs are gradually becoming mature. Meanwhile, MSCs differentiate into cells derived from mesoderm in the theory. Endothelial cells derived from the mesoderm, MSCs have potency of differentiated into endothelial cells (ECs). This review focuses on the significance and cytological basis of human MSCs differentiate into endothelial cells, as well as the recent advancement and application on the tissue engineering.
Guo
Xin
X
The Key Laboratory of Pathobiology, Ministry of Education, Basic Medical School, Jilin University, Changchun 130021.
Li
Yu-Lin
YL
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D023822:Tissue Engineering