Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.
Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.
Chinnery
P F
PF
Mitochondrial Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. P.F.Chinnery@ncl.ac.uk
Elliott
H R
HR
Patel
S
S
Lambert
C
C
Keers
S M
SM
Durham
S E
SE
McCarthy
M I
MI
Hitman
G A
GA
Hattersley
A T
AT
Walker
M
M
D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D015201:Meta-Analysis as Topic; D011066:Poly C / Q000235:genetics*
D004272:DNA, Mitochondrial; D011066:Poly C