title: Trace amines reduce GABA(B) receptor-mediated presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta.
abstract: Trace amines (TAs) act in the mammalian brain through amphetamine-like effects and as endogenous agonists of specific receptors. We now show that tyramine and beta-phenylethylamine, in the presence of specific dopamine (DA) receptor antagonists, inhibit the GABA(B)-dependent presynaptic inhibition of GABAergic inputs to midbrain DA neurons. Our results further extend the role of TAs as neuromodulators and propose a novel mechanism by which they modulate DA neurons.
authors.affiliation: Fondazione Santa Lucia IRCCS, Via Ardeatina 306, 00179 Rome, Italy. n.berretta@hsantalucia.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Berretta
authors.forename: Michela
authors.initials: M
authors.lastname: Giustizieri
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bernardi
authors.forename: Nicola B
authors.initials: NB
authors.lastname: Mercuri
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D018755:GABA Agonists / Q000378:metabolism; D009433:Neural Inhibition / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism*
chemical_list: D015306:Biogenic Monoamines; D018755:GABA Agonists; D018377:Neurotransmitter Agents; D018080:Receptors, GABA-B; D004298:Dopamine