Cyclohexenones as Michael acceptors in the Staunton-Weinreb annulation: a simple stannane modification for the synthesis of polycyclic systems.
[reaction: see text] o-Toluate anions generated via transmetalation from the corresponding tributyl stannane underwent a Michael addition-Dieckmann condensation sequence with various cyclohexenones. This protocol provides an efficient entry into complex polycyclic systems without the use of beta-alkoxy enones hitherto required for the reaction.
Hill
Bryan
B
Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1.
Rodrigo
Russell
R