title: Static pressure volume curves and body posture in acute respiratory failure.
abstract: OBJECTIVE
  In acute respiratory distress syndrome the body posture effects on pressure-volume (PV) curves are still unclear. We examined the effects of prone position on inflation PV curves and their potential relationships with postural alterations in gas exchange.
  
  
  METHODS
  Prospective study with patients serving as their own controls in a university-affiliated 30-bed intensive care unit.
  
  
  METHODS
  Thirteen anesthetized, paralyzed, semirecumbent, mechanically ventilated patients with early/severe/diffuse ARDS.
  
  
  METHODS
  Sequential body posture changes: preprone semirecumbent, prone, and postprone semirecumbent.
  
  
  RESULTS
  In each posture hemodynamics, gas exchange, and lung volumes were determined before/during removal and after restoration of positive end-expiratory pressure (PEEP=10.2+/-0.6 cmH2O). At zero PEEP PV curves of respiratory system, lung, and chest wall were constructed. Prone position vs. preprone semirecumbent resulted in significantly reduced pressure at lower inflection point of lung PV curve (2.2+/-0.2 vs. 3.7+/-0.5 cmH2O) and increased volume at upper inflection point (0.87+/-0.03 vs. 0.69+/-0.05 l). Postural reduction in lower inflection point pressure of lung PV curve was the sole independent predictor of pronation-induced increases in PaO2/FIO2 (R2=0.76). PaO2/FIO2 increases were also significantly related with increases in functional residual capacity (R2=0.60).
  
  
  CONCLUSIONS
  In early/severe/diffuse ARDS prone position reduces lower inflection point pressure and increases upper inflection point UIP volume of the lung PV curve. Lower inflection point pressure reductions explain oxygenation improvements, which are also associated with a postural increase in functional residual capacity.
authors.affiliation: sdm@hol.gr
authors.forename: Spyros D
authors.initials: SD
authors.lastname: Mentzelopoulos
authors.forename: Charis
authors.initials: C
authors.lastname: Roussos
authors.forename: Spyros G
authors.initials: SG
authors.lastname: Zakynthinos
mesh_terms: D000328:Adult; D002407:Catheterization, Swan-Ganz; D005260:Female; D005652:Functional Residual Capacity; D006439:Hemodynamics; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011175:Positive-Pressure Respiration / Q000379:methods*; D011187:Posture; D016684:Prone Position; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D015656:Respiratory Mechanics