Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by small cell lung carcinoma.
We report a 75-year-old man who developed herpes simplex encephalitis (HSE), presenting with bilateral hippocampal lesions on magnetic resonance imaging, and this case was simultaneously complicated by small cell lung carcinoma. We identified a new anti-neuronal antibody in the cerebrospinal fluid of this patient. Our findings suggest that HSE and paraneoplastic limbic encephalitis (PLE) can overlap, and we discuss the relationships of HSE, PLE, and related disorders.
Hirai
Ryo
R
First Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Japan.
Ayabe
Mitsuyoshi
M
Shoji
Hiroshi
H
Kaji
Masahide
M
Ichiyama
Takashi
T
Sakai
Koichiro
K
D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000134:cerebrospinal fluid; D018288:Carcinoma, Small Cell / Q000150:complications*; D002531:Cerebellum / Q000276:immunology; D020803:Encephalitis, Herpes Simplex / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D020363:Limbic Encephalitis / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology
D001323:Autoantibodies; D009419:Nerve Tissue Proteins