A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3.
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a candidate gene for schizophrenia. DISC1 is disrupted by a balanced t(1;11)(q42.1;q14.3) translocation segregating with schizophrenia and related psychiatric illness in a large Scottish family. Here, we show that DISC1 interacts via its globular domain with the p40 subunit of the eukaryotic translation initiation factor 3. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses. Our findings suggest that DISC1 may function as a translational regulator and may be involved in stress response.
Ogawa
Fumiaki
F
Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Kasai
Mana
M
Akiyama
Tetsu
T
D002460:Cell Line; D003594:Cytoplasmic Granules / Q000378:metabolism*; D039621:Eukaryotic Initiation Factor-3 / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D013223:Statistics as Topic
C412476:DISC1 protein, human; D039621:Eukaryotic Initiation Factor-3; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C076751:TIAL1 protein, human