PDF has found its receptor.
The neuropeptide pigment-dispersing factor (PDF) is a crucial component of the insect circadian clock, but the identity of its receptor has long remained a mystery. In this issue of Neuron, three papers (Hyun et al., Lear et al., and Mertens et al.) identify the PDF receptor.
Helfrich-Förster
Charlotte
C
University of Regensburg, Institute of Zoology, Universitätsstrasse 31, 93040 Regensburg, Germany.
D000818:Animals; D001921:Brain / Q000166:cytology; D002940:Circadian Rhythm / Q000502:physiology; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009479:Neuropeptides / Q000378:metabolism* / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism* / Q000502:physiology
D029721:Drosophila Proteins; D009479:Neuropeptides; D043562:Receptors, G-Protein-Coupled; C113883:pdf protein, Drosophila