Cross-metathesis assisted by microwave irradiation.
Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the phosphine-free Hoveyda-Grubbs catalyst and the "second generation Grubbs' catalyst." While there have been reports that a "microwave effect" is observed in various transformations, the accelerations we observe are due to the efficient and rapid heating and increased pressure in the microwave apparatus.
Bargiggia
Frédéric C
FC
Johnson & Johnson Pharmaceutical Research and Development L.L.C., 1000 Route 202, P.O. Box 300, Raritan, New Jersey 08869, USA.
Murray
William V
WV
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006361:Heating; D008872:Microwaves; D008968:Molecular Conformation; D015394:Molecular Structure
D000475:Alkenes