title: Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients.
abstract: BACKGROUND
  Continuous peripheral nerve block (CPNB) is the technique of choice for postoperative analgesia after painful orthopedic surgery. However, the incidence of neurologic and infectious adverse events in the postoperative period are not well established. This issue was the aim of the study.
  
  
  METHODS
  Patients scheduled to undergo orthopedic surgery performed with a CPNB were prospectively included during 1 yr in a multicenter study. Efficacy of postoperative analgesia, bacteriologic cultures of the catheter, and acute neurologic and infectious adverse events were evaluated after surgery in 1,416 patients at arrival in the postanesthesia care unit, at hour 1, and every 24 h up to day 5. Risk factors for adverse events were determined using logistic regression.
  
  
  RESULTS
  The median duration of CPNB was 56 h. Both general anesthesia and CPNB were performed in 73.6% of the patients. Postoperative analgesia was effective in 96.3%, but an increase in pain scores was noted at hour 24 (P = 0.01). Hypoesthesia or numbness occurred in 3% and 2.2%, respectively, and paresthesia occurred in 1.5%. Three neural lesions (0.21%) were noted after continuous femoral nerve block. Two of these patients were anesthetized during block procedure. Nerve damage completely resolved 36 h to 10 weeks later. Cultures from 28.7% of the catheters were positive. Three percent of patients had local inflammatory signs. The bacterial species most frequently found were coagulase-negative staphylococcus (61%) and gram-negative bacillus (21.6%). A Staphylococcus aureus psoas abscess (0.07%) was reported in one diabetic woman. Independent risk factors for paresthesia/dysesthesia were postoperative monitoring in intensive care, age less than 40 yr, and use of bupivacaine. Risk factors for local inflammation/infection were postoperative monitoring in intensive care, catheter duration greater than 48 h, male sex, and absence of antibiotic prophylaxis.
  
  
  CONCLUSIONS
  CPNB is an effective technique for postoperative analgesia. Minor incidents and bacterial colonization of catheters are frequent, with no adverse clinical consequences in the large majority of cases. Major neurologic and infectious adverse events are rare.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Lapeyronie University Hospital, Montpellier, France. x-capdevila@chu-montpellier.fr
authors.forename: Xavier
authors.initials: X
authors.lastname: Capdevila
authors.forename: Philippe
authors.initials: P
authors.lastname: Pirat
authors.forename: Sophie
authors.initials: S
authors.lastname: Bringuier
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Gaertner
authors.forename: François
authors.initials: F
authors.lastname: Singelyn
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bernard
authors.forename: Olivier
authors.initials: O
authors.lastname: Choquet
authors.forename: Hervé
authors.initials: H
authors.lastname: Bouaziz
authors.forename: Francis
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000009:adverse effects*; D009422:Nervous System Diseases / Q000139:chemically induced / Q000453:epidemiology; D019637:Orthopedic Procedures; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology*; D010525:Peripheral Nerves; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000779:Anesthetics, Local