New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.
Suling
W J
WJ
Southern Research Institution, Birmingham, Alabama, USA.
Seitz
L E
LE
Reynolds
R C
RC
Barrow
W W
WW
D004094:Dihydropteroate Synthase / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D011743:Pyrimidines; C506974:SRI-8858; D004094:Dihydropteroate Synthase