title: Teratogenic effects of static magnetic field on mouse fetuses.
abstract: A short period of exposure of pregnant mice to a strong static magnetic field of 400 mT -- 8000 times that of the earth -- in a dorso-ventral direction had teratogenic effects on developing fetuses. Fetuses were exposed to the static magnetic field in utero for 6 min on 1 day from 7.5 to 14.5 days of pregnancy. Exposed and control groups consisted of 10 pregnant mice each; thus 160 animals were used in total. Various malformations were observed in 15.1%, 13.4%, 15.8%, 16.7%, 20.8%, 24.3%, 24.4%, and 14.1% of fetuses exposed on days 7.5, 8.5, 9.5, I0.5, 11.5, 12.5, 13.5, and 14.5 of pregnancy, respectively. Types of malformations were polydactylism, abdominal fissure, fused rib, vestigial 13th rib, lumbar rib, brain hernia, and curled tail, while only a low incidence (up to 2.8%) of curled tail was detected in control group. These deformations apparently caused by SMF exposure but the effect did not reflect so-called exposure period specificity.
authors.affiliation: Department of Veterinary Physiology, Nippon Veterinary and Animal Science University, Musashino-shi, Tokyo 180-8602, Japan. kenichisaito@gold.livedoor.com
authors.forename: Kenichi
authors.initials: K
authors.lastname: Saito
authors.forename: Hiroetsu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Katsushi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000528:radiation effects; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D047109:Fetal Development / Q000528:radiation effects*; D005333:Fetus / Q000002:abnormalities / Q000528:radiation effects*; D005552:Forelimb / Q000002:abnormalities / Q000528:radiation effects; D006614:Hindlimb / Q000002:abnormalities / Q000528:radiation effects; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008815:Mice, Inbred Strains; D017689:Polydactyly / Q000196:embryology / Q000209:etiology; D011247:Pregnancy; D012272:Ribs / Q000002:abnormalities / Q000528:radiation effects; D013270:Stomach / Q000002:abnormalities / Q000528:radiation effects; D013696:Temperature; D018600:Teratology / Q000379:methods