title: Sequential treatment for proctalgia fugax. Mid-term follow-up.
abstract: BACKGROUND
  Proctalgia fugax (PF) is a benign, self-limiting disease characterized by episodes of intense anorectal pain at frequent intervals in the absence of organic proctological disease. Even though PF was described more than a century ago, its etiology remains unclear. Currently there is no information available. Few papers quoting many ways of management have been published. The aim of this study was to investigate patients complaining of this condition and to treat them with sequential therapy.
  
  
  METHODS
  We devised a descriptive, prospective study of patients complaining of acute perianal pain--duration less than 30 minutes--without organic disease or previous perianal surgery since 1996 to 2002 in our Department. We treated these patients using a three-step treatment (1: information, hip bath, benzodiazepines; 2: sublingual nifedipine 10 mg, or topic 0.1% nitroglycerin on demand; 3: internal anal sphincterotomy if hypertrophy of the internal anal sphincter was demonstrated by anal ultrasonography and no improvement was confirmed with the previous steps of treatment). We defined remarkable improvement as a decrease in the number of episodes by half or in pain intensity by 50%.
  
  
  RESULTS
  Fifteen patients with an average follow-up of 4 years. Anal endosonography confirmed a grossly thickened internal anal sphincter (IAS) in 5 cases. After the first step of treatment 7 patients improved and 1 patient was cured; after the second step of treatment 3 patients improved and 1 was cured; the third step was applied to 3 patients with a thickened IAS; 1 patient improved and 1 patient was cured.
  
  
  CONCLUSIONS
  A total resolution of PF is not always possible, but we may improve symptoms and their frequency. Almost 50% of patients in our series improved with the first step of treatment; 30% of our patients had IAS hypertrophy. Anal endosonography can help in the diagnosis of organic diseases or IAS hypertrophy, for which we can perform an internal anal sphincter myectomy.
authors.affiliation: Department of Surgery B, Hospital Clínico Universitario, Zaragoza, Spain. josegraciasolanas@hotmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Gracia Solanas
authors.forename: J M
authors.initials: JM
authors.lastname: Ramírez Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Elía Guedea
authors.forename: V
authors.initials: V
authors.lastname: Aguilella Diago
authors.forename: M
authors.initials: M
authors.lastname: Martínez Díez
mesh_terms: D000208:Acute Disease; D000328:Adult; D001003:Anal Canal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001004:Anus Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D001494:Baths; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D059408:Pain Management; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D014665:Vasodilator Agents; D001569:Benzodiazepines; D005996:Nitroglycerin; D009543:Nifedipine