title: Inhibition of pro-inflammatory cytokine receptor signalling by cAMP in vascular endothelial cells.
abstract: The anti-inflammatory effects of the prototypical second messenger cAMP have been extensively documented in multiple cell types. However, in many instances, the molecular mechanisms by which cAMP elevation disrupts specific pro-inflammatory signalling cascades are unknown. In this review, we will describe the importance of the JAK-STAT (where JAK stands for Janus kinase and STAT for signal transducer and activator of transcription) signalling pathway in vascular endothelial cell function, outline key inhibitory processes that serve to reduce cytokine-stimulated tyrosine phosphorylation and activation of STAT proteins, and discuss possible mechanisms by which intracellular cAMP sensors could interact with these inhibitory processes to diminish cytokine receptor-mediated pro-inflammatory signalling.
authors.affiliation: Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK.
authors.forename: W A
authors.initials: WA
authors.lastname: Sands
authors.forename: T M
authors.initials: TM
authors.lastname: Palmer
mesh_terms: D000242:Cyclic AMP / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D018121:Receptors, Cytokine / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D050826:Suppressor of Cytokine Signaling Proteins / Q000502:physiology
chemical_list: D018121:Receptors, Cytokine; D050826:Suppressor of Cytokine Signaling Proteins; D000242:Cyclic AMP