Changes in plasma volume associated with mental stress ischemia in patients with coronary artery disease.
Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radionuclide ventriculography during a multiple stress challenge. Plasma volume was assessed during rest and at the end of the stress task. Flow-mediated dilatation was also measured. Controlling for endothelial function and medications, patients with ischemia had greater reductions in plasma volume than non-ischemic patients. Reduced plasma volume may be one mechanism by which mental stress may increase the risk for acute coronary events.
Bacon
Simon L
SL
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. simon.bacon@concordia.ca
Sherwood
Andrew
A
Hinderliter
Alan L
AL
Coleman
R Edward
RE
Waugh
Robert
R
Blumenthal
James A
JA
D000368:Aged; D001143:Arousal / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D014664:Vasodilation / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology