title: Myocardial ischemia induced by nebulized fenoterol for severe childhood asthma.
abstract: We examined for myocardial ischemia induced by continuous inhalation of fenoterol in children with severe acute asthma. Thirty children with severe acute asthma were evaluated for signs of myocardial ischemia when treated with 0.5 mg kg dose (maximum 15 mg) of inhaled fenoterol for one hour. The heart rate was measured before and after inhalation. Cardiac enzymes (creatine kinase, creatine kinase MB fraction and troponin levels) were measured at admission and 12 hours later. An EKG was recorded before inhalation was started and immediately after its completion to detect the presence of any evidence of myocardial ischemia. All patients developed significant increase in heart rate. Six patients showed EKG changes compatible with myocardial ischemia, despite normal enzyme levels. Patients with severe acute asthma show tachycardia and may show EKG changes of myocardial ischemia.
authors.affiliation: Department of Pediatrics, Hospital Universitario, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil. Izzanoni@terra.com.br
authors.forename: L Z
authors.initials: LZ
authors.lastname: Zanoni
authors.forename: D B
authors.initials: DB
authors.lastname: Palhares
authors.forename: L C T
authors.initials: LC
authors.lastname: Consolo
mesh_terms: D000280:Administration, Inhalation; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced*; D018709:Statistics, Nonparametric
chemical_list: D001993:Bronchodilator Agents; D005280:Fenoterol