title: Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?
abstract: Mantle cell lymphoma (MCL) is a B-cell neoplasm with a relatively aggressive clinical course. There is a very small subgroup of patients who present with atypical lymphocytes in peripheral blood, with or without lymphocytosis, lymphadenopathy, or splenomegaly, and with an indolent clinical course. They frequently show mutated IgV(H) genes and CD5 negativity. We report an asymptomatic elderly patient who presented with a single submandibular lymphadenopathy. The biopsy showed immunophenotype and t(11;14)(q13;q32) consistent with MCL. The abnormal lymphoid population was also detected in peripheral blood and bone marrow. The patient has remained asymptomatic for 5 years without receiving any therapy. It is uncertain whether these cases represent an early-stage event in the development or an indolent form of MCL. The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions.
authors.affiliation: Servei de Patologia (Laboratori de Citogenètica i Biologia Molecular, Laboratori de Citologia Hematològica, Laboratori de Patologia), Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain. bespinet@imas.imim.es
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Francesc
authors.initials: F
authors.lastname: Solé
authors.forename: Carme
authors.initials: C
authors.lastname: Pedro
authors.forename: Mar
authors.initials: M
authors.lastname: Garcia
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.forename: Marta
authors.initials: M
authors.lastname: Salido
authors.forename: Lourdes
authors.initials: L
authors.lastname: Florensa
authors.forename: Francisca I
authors.initials: FI
authors.lastname: Camacho
authors.forename: Teresa
authors.initials: T
authors.lastname: Baró
authors.forename: Josep
authors.initials: J
authors.lastname: Lloreta
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D019938:Cyclin D1 / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000473:pathology*; D008214:Lymphocytes / Q000097:blood / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D016133:Polymerase Chain Reaction
chemical_list: D019938:Cyclin D1