title: The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
abstract: Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.
authors.affiliation: Department of Chemistry and Oxford Centre for Molecular Sciences, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, UKOX1 3TA.
authors.forename: Biswadip
authors.initials: B
authors.lastname: Banerji
authors.forename: Ana
authors.initials: A
authors.lastname: Conejo-Garcia
authors.forename: Luke A
authors.initials: LA
authors.lastname: McNeill
authors.forename: Michael A
authors.initials: MA
authors.lastname: McDonough
authors.forename: Matthew R G
authors.initials: MR
authors.lastname: Buck
authors.forename: Kirsty S
authors.initials: KS
authors.lastname: Hewitson
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Oldham
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D010105:Oxygenases / Q000378:metabolism; D014176:Protein Biosynthesis; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D002264:Carboxylic Acids; D012097:Repressor Proteins; D014157:Transcription Factors; D010105:Oxygenases