title: Sweat production during global heating and during isometric exercise in people with diabetes.
abstract: BACKGROUND
  While sweat production in response to heat is impaired in people with diabetes, sweat production has not been examined during isometric exercise.
  
  
  METHODS
  Eight subjects with type 2 diabetes and 9 control subjects exerted a fatiguing isometric contraction of the handgrip muscles at a tension of 40% of the maximum voluntary strength (MVC) after exposure to a 32 deg C environment for 30 min. compared to 10 controls and 10 subjects with diabetes exposed to a 39 deg C environment.
  
  
  RESULTS
  Sweat was impaired to all areas of the body during heat exposure in patients with diabetes under both environmental conditions. For example, on the chest, the average sweat rates after exposure to the 32 deg environment was 259.2 +/- 55.2 nanoliters/min in control subjects and 198.3 +/- 46.2 nanoliters/min for subjects with diabetes. Compared to the 32 deg C environment, control subjects increased sweat in all 4 areas proportionally more than subjects with diabetes. Sudomotor rhythm was present in sweat in control subjects at a rate of repetition of 11 and 50 seconds but almost absent in subjects with diabetes. During exercise, sweat rates slowly increased from the beginning to the end of the exercise. But the head of the subjects with diabetes showed hypersweating while the other areas showed diminished sweating compared to control subjects.
  
  
  CONCLUSIONS
  Thus some of the impairment in sweating may be due to central mechanisms associated with heat sensitivity or in the hypothalamus and not to the sweat glands themselves.
authors.affiliation: Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA. jerry-petrofsky@sahp.llu.edu
authors.forename: Jerrold Scott
authors.initials: JS
authors.lastname: Petrofsky
authors.forename: Scott
authors.initials: S
authors.lastname: Lee
authors.forename: Chris
authors.initials: C
authors.lastname: Patterson
authors.forename: Melissa
authors.initials: M
authors.lastname: Cole
authors.forename: Brian
authors.initials: B
authors.lastname: Stewart
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D015444:Exercise; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D013545:Sweat Glands / Q000503:physiopathology*; D013546:Sweating