title: Synthesis of isoxazoles via electrophilic cyclization.
abstract: [reaction: see text] A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or PhSeBr.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Jesse P
authors.initials: JP
authors.lastname: Waldo
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis*; D007555:Isoxazoles / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D006846:Hydrocarbons, Halogenated; D007555:Isoxazoles