title: Apolipoprotein E genotype in matched men and women with coronary heart disease.
abstract: Apolipoprotein E (apo E) plays an important role in lipid metabolism and its polymorphism may be a risk determinant of coronary heart disease (CHD). Since evidence suggested a gender-specific effect of apo E polymorphism, we studied the influence of gender-specific interaction of the polymorphism on CHD. From a total of 463 Greek Caucasians (314 men and 149 postmenopausal women) with angiographically documented CHD, we selected 79 women (68+/- 9 yr old) and 79 men (66+/- 9 yr old) who were matched for clinical characteristics. Apo E genotyping was performed by PCR and RFLP analysis. Biochemical parameters were also measured. The results were as follows: the E3/3 genotype occurred in 78.5% of the patients, followed by E3/4, E2/3, E2/4, and E4/4 genotypes, which occurred in 9.5%, 9.5%, 1.9%, and 0.6% of the patients, respectively. No significant differences were observed in the apo E allele or apo E genotype distributions between the matched Greek men and women with CHD. The E3/3 men patients were more frequently part of a family with a history of CHD, compared to women (p=0.035).
authors.affiliation: Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece. genkolovou@mail.gr
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Anagnostopoulou
authors.forename: Klelia D
authors.initials: KD
authors.lastname: Salpea
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Hoursalas
authors.forename: Marios A
authors.initials: MA
authors.lastname: Cariolou
authors.forename: Katerina
authors.initials: K
authors.lastname: Koniavitou
authors.forename: Dennis V
authors.initials: DV
authors.lastname: Cokkinos
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D017698:Postmenopause; D012737:Sex Factors; D044465:White People
chemical_list: D001057:Apolipoproteins E