RNA inhibition of beta-secretase reverts AD in mice.
Burton
Adrian
A
D000544:Alzheimer Disease / Q000201:enzymology* / Q000473:pathology / Q000628:therapy*; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D010450:Endopeptidases; D005822:Genetic Vectors; D006624:Hippocampus; D006801:Humans; D007267:Injections; D016086:Lentivirus / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000096:biosynthesis; D034741:RNA, Small Interfering / Q000627:therapeutic use*
D016564:Amyloid beta-Protein Precursor; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse