title: Topical delivery of retinyl ascorbate co-drug: 6. Determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes.
abstract: The maximum effective dose of retinyl ascorbate and its potential therapeutic benefits against induced oxidative damage were assessed in vitro using cultured human epidermal keratinocytes. RA-AsA exhibited toxic effects at concentrations >6 microM. The findings indicate to the potency of RA-AsA as free radical scavenger and cell proliferation regulator.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, UK.
authors.forename: K
authors.initials: K
authors.lastname: Abdulmajed
authors.forename: C
authors.initials: C
authors.lastname: McGuigan
authors.forename: C M
authors.initials: CM
authors.lastname: Heard
mesh_terms: D000287:Administration, Topical; D000975:Antioxidants / Q000008:administration & dosage* / Q000633:toxicity*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D002452:Cell Count; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D012176:Retinoids / Q000008:administration & dosage* / Q000633:toxicity*; D000084562:Retinyl Esters; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D012176:Retinoids; D000084562:Retinyl Esters; C504062:retinyl ascorbate; D001205:Ascorbic Acid