[Study on the expression of HSP70 and HSP90beta in nasopharyngeal carcinoma and the clinical significance].
OBJECTIVE
To study the expression of HSP70 and HSP90beta and its clinical significance in human nasopharyngeal carcinoma.


METHODS
Immunohistochemical method SP was used to detect the expression of HSP70 and HSP90beta in 50 cases and its clinical significance were studied.


RESULTS
The positive rate of HSP70 and HSP90beta were 72% and 56% respectively. Analysis of patients, survival demonstrated that the prognosis of NPC with HSP70 (-) and HSP90beta (-) expression were significantly better than the others.


CONCLUSIONS
The overexpression of HSP70 and HSP90beta were probably concerned with the occurrence, development and prognosis of nasopharyngeal carcinoma.
Liu
Tao
T
Department of Otorhinolaryngology, West China Hospital, Sichuan University, Chengdu 610041, China.
Liang
Chuanyu
C
Tian
Ling
L
Wei
Yuquan
Y
Zhao
Jumei
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D055815:Young Adult
D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C493165:HSP90AB1 protein, human