title: Wear patterns on tibial plateau from varus osteoarthritic knees.
abstract: BACKGROUND
  The knowledge of cartilage wear patterns at the medial tibial plateau is important to understand the main causes of arthritis in varus knees. The most important factors influencing knee arthritis in fact seem to be the severity of the degenerative changes determined by the lower limb mechanical axis and the abnormal knee joint kinematics which frequently results from dysfunction of the anterior cruciate ligament.
  
  
  METHODS
  We studied the wear patterns of cartilage damage in 70 medial tibial plateaus resected at operation during total knee arthroplasty indicated for varus osteoarthritic knee. Anterior cruciate ligament and medial meniscus integrity was assessed intra-operatively. Calibrated digital images were used to measure the wear patterns with a standard software tool. The medial compartment of the tibial plateau was divided into six zones, and the amount of cartilage and bone destruction in each zone was classified into two grades.
  
  
  RESULTS
  The wear pattern was found to be highly dependent upon knee varus deformity (Mann Whitney P<0.001) and anterior cruciate ligament integrity (Friedman P<0.0005). Anterior cruciate ligament was found intact in 35.7% of the cases. Wear patterns on intact anterior cruciate ligament knees occurred in the central to medial aspect of the tibial plateau. Anterior cruciate ligament deficient knees had significantly larger wear patterns anteriorly and posteriorly in the most medial region of the medial plateau.
  
  
  CONCLUSIONS
  These observations suggest altered joint mechanics exist in anterior cruciate ligament deficient varus knees, which would worsen cartilage degeneration and osteoarthritis progression.
authors.affiliation: Movement Analysis Laboratory, Istituti Ortopedici Rizzoli, Bologna and Department of Mechanics, University of Calabria, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Moschella
authors.forename: A
authors.initials: A
authors.lastname: Blasi
authors.forename: A
authors.initials: A
authors.lastname: Leardini
authors.forename: A
authors.initials: A
authors.lastname: Ensini
authors.forename: F
authors.initials: F
authors.lastname: Catani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D006801:Humans; D016916:Joint Deformities, Acquired / Q000209:etiology / Q000473:pathology*; D007719:Knee Joint / Q000473:pathology*; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D013977:Tibia