HLA DQB1*0602 positive narcoleptic subjects with cataplexy have CSF lgG reactive to rat hypothalamic protein extract.
Black
John L
JL
Avula
Rajeswari K
RK
Walker
Denise L
DL
Silber
Michael H
MH
Krahn
Lois E
LE
Pankratz
V Shane
VS
Fredrickson
Paul A
PA
Slocumb
Nancy L
NL
D000328:Adult; D000368:Aged; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002385:Cataplexy / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D007031:Hypothalamus / Q000276:immunology* / Q000378:metabolism; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid* / Q000276:immunology*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009290:Narcolepsy / Q000134:cerebrospinal fluid / Q000235:genetics / Q000276:immunology; D064446:Orexin Receptors; D051381:Rats; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide / Q000276:immunology* / Q000378:metabolism; D012895:Sleep, REM / Q000502:physiology
D000906:Antibodies; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; D064446:Orexin Receptors; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide