Topiramate for phantom limb pain: a time-series analysis.
There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.
Harden
R Norman
RN
Center for Pain Studies, Rehabilitation Institute of Chicago/Northwestern University Medical School, Chicago, Illinois 60611, USA. nharden@rehabchicago.org
Houle
Tim T
TT
Remble
Thomas A
TA
Lin
Wendy
W
Wang
Kenten
K
Saltz
Samuel
S
D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy* / Q000523:psychology; D010147:Pain Measurement; D010591:Phantom Limb / Q000188:drug therapy* / Q000523:psychology; D010865:Pilot Projects; D013997:Time Factors; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose