title: Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques.
abstract: Peptide YY(3-36) [PYY(3-36)] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however, there are conflicting reports of the effects of PYY(3-36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY(3-36) on food intake and body weight in a nonhuman primate. Intravenous PYY(3-36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h intake. Twice-daily or continuous intravenous PYY(3-36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding for the morning but not the evening meal. Twice-daily intravenous PYY(3-36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing insulin response to glucose infusion. These results show that endogenous PYY(3-36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food intake.
authors.affiliation: Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
authors.forename: Frank H
authors.initials: FH
authors.lastname: Koegler
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Enriori
authors.forename: Sonja K
authors.initials: SK
authors.lastname: Billes
authors.forename: Diana L
authors.initials: DL
authors.lastname: Takahashi
authors.forename: Meghan S
authors.initials: MS
authors.lastname: Martin
authors.forename: Randall L
authors.initials: RL
authors.lastname: Clark
authors.forename: Anne E
authors.initials: AE
authors.lastname: Evans
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Grove
authors.forename: Judy L
authors.initials: JL
authors.lastname: Cameron
authors.forename: Michael A
authors.initials: MA
authors.lastname: Cowley
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005951:Glucose Tolerance Test; D008253:Macaca mulatta / Q000378:metabolism*; D008297:Male; D010446:Peptide Fragments; D019894:Peptide YY / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)