Distribution of anticancer drug camptothecin in Nothapodytes foetida.
The topoisomerase I-DNA inhibitor alkaloid camptothecin has been evaluated from the various parts of Nothapodytes foetida. The bark contained 0.27% dry wt of camptothecin and 0.11% dry wt 9-methoxycamptothecin followed by the root, stem, and leaves. Immature seeds contained higher concentrations of camptothecin (0.32% dry wt) and 9-methoxycamptothecin (0.16% dry wt) compared to mature seeds. Various parts of mature and immature seeds were analysed to determine the content of the major alkaloids. Zygotic embryos of immature seeds contained 0.11% dry wt of camptothecin and 0.04% dry wt of 9-methoxycamptothecin. The highest concentration of camptothecin (0.42% dry wt) and 9-methoxycamptothecin (0.18% dry wt) were accumulated in the cotyledons of immature seeds.
Fulzele
Devanand P
DP
Plant Biotechnology and Secondary Products Section, Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai-400085, India. dfulzele@hotmail.com
Satdive
Ramesh K
RK
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D019684:Magnoliopsida / Q000737:chemistry*; D018514:Plant Structures / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; C025724:9-methoxycamptothecin; D002166:Camptothecin