Cardiac toxicity from phenylpropanolamine overdose in a dog.
A 5-year-old, 29-kg, female Labrador retriever developed tachypnea, tachycardia, and ataxia following ingestion of approximately 48 mg/kg of phenylpropanolamine. Initial diagnostic tests showed multiform ventricular tachycardia, left ventricular dilatation with a focal dyskinetic region in the dorsal interventricular septum, and elevations in creatinine kinase and cardiac troponin I. All abnormalities resolved within 6 months. The transient electrocardiographic, echocardiographic, and biochemical abnormalities were consistent with myocardial necrosis from infarction or direct catecholamine-induced myocardial toxicity.
Crandell
John M
JM
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.
Ware
Wendy A
WA
D000818:Animals; D001262:Atenolol / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D062787:Drug Overdose / Q000662:veterinary; D004452:Echocardiography / Q000662:veterinary; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D010665:Phenylpropanolamine / Q000633:toxicity*; D013566:Sympathomimetics / Q000633:toxicity*; D016896:Treatment Outcome
D013566:Sympathomimetics; D010665:Phenylpropanolamine; D001262:Atenolol; D004656:Enalapril