Peculiarities of proliferation of epidermal cambial cells in mouse skin.
The long axis of epidermal cambial cells determining the direction of their division is determined before the beginning of division and is oriented perpendicularly, but not parallel, to the basal membrane, as in other basal cells. As a result, only one of the two newly formed cells adheres to the basal membrane and at the expense of traction forces detaching one cell from the other and elastic force of the basal membrane is formed as a maternal cell and stays in the focus of multiplication. The other cell, turning around under the effect of traction forces perpendicularly to the maternal cell, cardinally changes the direction of its long axis and is polarized parallel to the basal membrane like other cells. This cell becomes the daughter cell, its shape with the "head" and "tail" allows its rapid migration into other rosettes for differentiation.
Yavisheva
T M
TM
N. N. Blokhin National Center for Cancer Research, Russian Academy of Medical Sciences, Moscow.
Shcherbakov
S D
SD
Dubinkin
I V
IV
D000818:Animals; D002455:Cell Division / Q000502:physiology*; D049109:Cell Proliferation; D000078404:Epidermal Cells; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins; D013234:Stem Cells / Q000166:cytology*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim