The stereochemistry of ketoreduction.
In this issue of Chemistry & Biology, Leadlay and coworkers report overproduction of a number of ketoreductase domains from modular polyketide synthases. These discrete enzymes allow the stereochemistry of polyketide ketoreduction to be studied in isolation.
Caffrey
Patrick
P
School of Biomolecular and Biomedical Science and Centre for Synthesis and Chemical Biology, University College Dublin, Ireland.
D000429:Alcohol Oxidoreductases / Q000737:chemistry*; D001665:Binding Sites; D007659:Ketones / Q000737:chemistry; D010084:Oxidation-Reduction; D017434:Protein Structure, Tertiary; D013237:Stereoisomerism
D007659:Ketones; D000429:Alcohol Oxidoreductases