Anti-IgE therapy in allergic asthma.
Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.
Rolinck-Werninghaus
Claudia
C
Department of Paediatric Pneumology and Immunology, Charité, Campus Virchow, University Children's Hospital, Humboldt-University, Augustenburger Platz 1, D-13353 Berlin, Germany.
Wahn
Ulrich
U
Hamelmann
Eckard
E
D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D001249:Asthma / Q000628:therapy*; D005512:Food Hypersensitivity / Q000628:therapy; D006801:Humans; D007073:Immunoglobulin E / Q000737:chemistry / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy
D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies; D007073:Immunoglobulin E