title: New bis-spirolabdane-type diterpenoids from Leonurus heterophyllus Sw.
abstract: Twelve natural bis-spirolabdane-type diterpenoids, including eight new, named leoheteronones A-E, 15-epileoheteronones B, D, and E, and four known leopersin B, 15-epileopersin B, leopersin C, and 15-epileopersin C, together with hispanone and galeopsin were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus SW. (Lamiaceae) grown in Vietnam. Their structures were determined by spectroscopic analyses. The current study emphasized the accumulation of C-15 oxygenated bis-spirolabdane-type diterpenoids of both 13R and 13S configurations in L. heterophyllus.
authors.affiliation: Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, Vietnam.
authors.forename: Phan Minh
authors.initials: PM
authors.lastname: Giang
authors.forename: Phan Tong
authors.initials: PT
authors.lastname: Son
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Matsunami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Otsuka
mesh_terms: D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry*; D031332:Leonurus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D004224:Diterpenes