Derivatives of tramadol for increased duration of effect.
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.
Shao
Liming
L
Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. liming.shao@sepracor.com
Abolin
Craig
C
Hewitt
Michael C
MC
Koch
Patrick
P
Varney
Mark
M
D000701:Analgesics, Opioid / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D001665:Binding Sites; D003061:Codeine / Q000737:chemistry / Q000627:therapeutic use; D008956:Models, Chemical; D009020:Morphine / Q000737:chemistry / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D051381:Rats; D013997:Time Factors; D014147:Tramadol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use
D000701:Analgesics, Opioid; D014147:Tramadol; D009020:Morphine; D003061:Codeine