title: Treatment of massive cerebral infarction.
abstract: Stroke is the third leading cause of death in the United States, with a person dying every 3 minutes of a stroke. Massive ischemic stroke accounts for 10% to 20% of ischemic strokes, has traditionally been associated with a high mortality and morbidity, and requires a unique management strategy. Recent advances in management, fueled by an increased understanding of the pathophysiology, may help decrease mortality and improve outcomes. Rapid access to reperfusion therapies remains the most critical element of stroke care and the cornerstone of therapy. This article focuses on newer therapies, including osmotic therapy, hypothermia, maintained normothermia, strict glycemic control, induced hypertension, and hemicraniectomy, all of which show promise for reducing mortality and improving functional outcome. These interventions have become integrated into neurologic intensive care units around the world. They are complicated, require a high level of expertise, and carry a significant learning curve. In order for these new management techniques to be effective, an expedited, aggressive, meticulous, and potentially prolonged medical management approach is needed. To accomplish this there is a growing need for focused specialists in the areas of neurointensive care and stroke.
authors.affiliation: Neurological Institute, 710 West 168th Street, New York, NY 10032, USA. dpalestrant@neuro.columbia.edu
authors.forename: David
authors.initials: D
authors.lastname: Palestrant
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Frontera
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Mayer
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002544:Cerebral Infarction / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D004632:Emergency Medical Services; D006801:Humans; D007036:Hypothermia, Induced; D019635:Neurosurgical Procedures; D015424:Reperfusion; D020521:Stroke / Q000150:complications* / Q000453:epidemiology; D015912:Thrombolytic Therapy; D016896:Treatment Outcome