Protein surface recognition and proteomimetics: mimics of protein surface structure and function.
Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, alpha-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV.
Fletcher
Steven
S
Department of Chemistry, Yale University, CT 06520-8107, USA.
Hamilton
Andrew D
AD
D004791:Enzyme Inhibitors / Q000737:chemistry; D018716:Molecular Mimicry; D015394:Molecular Structure; D010449:Peptide Mapping; D011166:Porphyrins / Q000737:chemistry / Q000235:genetics; D011487:Protein Conformation; D017510:Protein Folding; D025941:Protein Interaction Mapping; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000502:physiology*
D004791:Enzyme Inhibitors; D011166:Porphyrins; D011506:Proteins