title: Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
abstract: Previously we found that 3,4-(methylenedioxy)-1-(2',3'-epoxypropyl)-benzene (safrole oxide) induced a typical apoptosis in A549 human lung cancer cells. In this study, we further investigated which caspases were activated by safrole oxide during the apoptosis. The data showed that the activity of caspase-3, -8, and -9 was significantly enhanced by the compound, which suggested that safrole oxide might be used as a caspase promoter to initiate lung cancer cell apoptosis.
authors.affiliation: Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.
authors.forename: Aiying
authors.initials: A
authors.lastname: Du
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Zhao
authors.forename: Deling
authors.initials: D
authors.lastname: Yin
authors.forename: Shangli
authors.initials: S
authors.lastname: Zhang
authors.forename: Junying
authors.initials: J
authors.lastname: Miao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis; D053148:Caspase 3; D053178:Caspase 6; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000378:metabolism*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003124:Colorimetry; D015195:Drug Design; D006801:Humans; D007249:Inflammation; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008956:Models, Chemical; D012451:Safrole / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; C009196:safrole oxide; C505407:CASP3 protein, human; C505514:CASP6 protein, human; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053148:Caspase 3; D053178:Caspase 6; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases; D012451:Safrole