title: [Acute response of serum PTH and bone markers after injection of 1alpha,25 (OH)2D3 and 22-oxacalcitrol in hemodialysis patient].
abstract: Time-course changes of serum PTH and various bone markers were compared after injection of 1alpha,25 (OH)(2)D(3) with that of 22-oxacalcitriol (OCT) in hemodialysis patients. Five patients (M/F; 3/2, mean ages of 61.6 years) were enrolled into the present study. Oral administration of vitamin D(3) derivatives was stopped at least one week before initiation of vitamin injection. After 1 week of single intravenous injection of OCT (5 microg), 1alpha,25 (OH)(2)D(3) (0.5 microg) was followed. Serum levels of intact PTH, intact osteocalcin, bone alkaline phosphatase, cross-linked N-telopeptides of type I collagen, calcium, and phosphate were measured before, 24h, and 48 h after injections of vitamin D(3) derivatives. Significant difference did not exist in time-course changes of serum PTH, any of bone markers, calcium and phosphate between after OCT and 1alpha,25 (OH)(2)D(3) injection. In conclusion, the present study may not support the presence of significant direct effect of vitamin D(3) derivatives on bone metabolism in hemodialysis patients.
authors.affiliation: Nozaki Clinic.
authors.forename: Genichi
authors.initials: G
authors.lastname: Shimizu
authors.forename: Shinji
authors.initials: S
authors.lastname: Mitani
authors.forename: Shin
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Kawakami
authors.forename: Kanji
authors.initials: K
authors.lastname: Nozaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Imanishi
authors.forename: Takami
authors.initials: T
authors.lastname: Miki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002117:Calcitriol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D015675:Osteocalcin; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002117:Calcitriol; C051883:maxacalcitol; D002118:Calcium