title: Synthesis and antioxidant efficiency of a new copolymer containing phosphorylated myo-inositol.
abstract: New data are constantly gathered to show the role of oxidative stress and the involvement of reactive oxygen species in the pathogenesis of degenerative diseases. InsP6 is able to coordinate iron metal in order to prevent iron-catalyzed free radical formation. The aim of the present paper is to describe a new synthetic strategy in order to prepare a polymeric structure containing chemical functions able to coordinate iron ions. Here, we report the synthesis of a copolymer containing phosphorylated myo-inositol groups and we evaluate its antioxidant efficiency. Such a system was synthesized by binding chemical groups susceptible of radical polymerization to myo-inositol. The synthesized monomer was copolymerized with N,N-dimethylacrylamide (DMAA) (molar ratio 1:3) and submitted to exhaustive phosphorylation. The reaction was proved by an assay specific for phosphate groups. Finally, we evaluated the copolymer's ability in inhibiting lipid peroxidation in rat liver microsomal membranes. This study showed that the designed macromolecular system is particularly effective as antioxidant.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università della Calabria, 87036 Rende (CS), Italy. francesca.iemma@unical.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Iemma
authors.forename: Sonia
authors.initials: S
authors.lastname: Trombino
authors.forename: Francesco
authors.initials: F
authors.lastname: Puoci
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cirillo
authors.forename: Umile Gianfranco
authors.initials: UG
authors.lastname: Spizzirri
authors.forename: Rita
authors.initials: R
authors.lastname: Muzzalupo
authors.forename: Nevio
authors.initials: N
authors.lastname: Picci
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007295:Inositol Phosphates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D000178:Acrylamides; D000975:Antioxidants; D007295:Inositol Phosphates; D011108:Polymers; C507883:poly(4-vinylbenzylinositol polyphosphate-co-N,N-dimethylacrylamide)