The alpha(1D)-adrenergic receptor: cinderella or ugly stepsister.
This Perspective focuses on the alpha(1D)-adrenergic receptor (AR), the often neglected sibling of the alpha(1)-AR family. This neglect is due in part to its poor cell-surface expression. However, it has recently been shown that dimerization of the alpha(1D)-AR with either the alpha(1B)-AR or the beta(2)-AR increases alpha(1D)-AR cell-surface expression, and in this issue of Molecular Pharmacology, Hague et al. (p. 45) demonstrate that dimerization of the alpha(1D)-AR with the alpha(1B)-AR not only leads to increased cell-surface expression but also results in the formation of a novel functional entity.
Finch
Angela M
AM
Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, 2010 NSW, Australia.
Graham
Robert M
RM
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D019281:Dimerization; D006801:Humans; D011485:Protein Binding; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism / Q000502:physiology*
C547719:ADRA1D protein, human; D018340:Receptors, Adrenergic, alpha-1