Microwaves synthesis of solid supports for the synthesis of 3'-aminoalkyl oligodeoxynucleotides.
Phthalimido-alkyl alcohol solid supports were rapidly prepared from solid supported phthalic anhydride and amino alcohol condensation induced by microwaves. These supports were used to synthesize 13-aminoalkyl oligodeoxynucleotides allowing a two step deprotection necessary to avoid aminolink alkylation.
Goussu
Charles
C
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université de Montpellier II, Montpellier Cedex 5, France.
Vasseur
Jean-Jacques
JJ
Bazin
Hervé
H
Morvan
François
F
D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry; D008872:Microwaves; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013997:Time Factors; D014466:Ultraviolet Rays
D009841:Oligonucleotides; D004247:DNA