[Glucose metabolism].
The markedly increased peri-interventional risk (PCI and CABG) in patients with type-2 diabetes mellitus may be reduced by adjusting blood glucose values to a near-normal level. This adjustment should be realized acutely by glucose-insulin-potassium infusions. In long-term therapy, the target value should be achieved independent of the pharmacological principle of blood glucose reduction. Among the available oral antidiabetic agents, metformin, acarbose and glitazones seem to be cardioprotective via pleotropic effects. Given an optimal stent implantation and administration of GP IIb/IIIa inhibitors during coronary interventions, results are similar to those of non-diabetics.
Eckert
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S
Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik, Ruhr-Universität Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany. seckert@hdz-nrw.de
Tschöpe
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D
D002316:Cardiotonic Agents / Q000008:administration & dosage*; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000601:surgery*; D002986:Clinical Trials as Topic; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000401:mortality*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D015994:Incidence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome
D002316:Cardiotonic Agents; D007004:Hypoglycemic Agents