Development of methods for the quantification of essential and toxic elements in human biomonitoring.
Analytical methods using sector field ICP-MS and ICP-AES were developed for the determination of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, Tl, V, W, Zn and Zr in cerebrospinal fluid, urine, serum and blood. Sample treatment procedures merging high sample throughput, simplicity and low contamination risk were set up. Method performances were evaluated in terms of detection limits, accuracy and precision. The limits were below 0.05 ng ml(-1) for all the elements, except for Al (all matrices), Hg (blood), Pb (blood) and Sn (serum and blood). The accuracy varied from 86% to 110% and the precision was always below 6%.
Bocca
Beatrice
B
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
Forte
Giovanni
G
Petrucci
Francesco
F
Senofonte
Oreste
O
Violante
Nicola
N
Alimonti
Alessandro
A
D016477:Artifacts; D001826:Body Fluids / Q000737:chemistry* / Q000528:radiation effects; D002138:Calibration; D019963:Clinical Chemistry Tests; D004602:Elements; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D007202:Indicators and Reagents; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D008670:Metals / Q000032:analysis; D008872:Microwaves; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000378:metabolism; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods*; D014131:Trace Elements / Q000032:analysis
D004602:Elements; D007202:Indicators and Reagents; D008670:Metals; D014131:Trace Elements