title: Tuberculosis: an uncommon cause of cerebral venous thrombosis?
abstract: Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations. We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black presented abrupt right hemiparestesis, and hemiparesis. Investigations revealed CVT. Cerebral spinal fluid (CSF) examination evidenced an infection by Mycobacterium. He was heterozygous for G20210A prothrombin mutation. Probably, hypercoagulability mechanisms of TB, added to mutation of prothrombin gene increase the risk of CVT.
authors.affiliation: Division of Neurology, Universidade Federal de São Paulo, São Paulo, SP, Brazil. fiorotjr@terra.com.br
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Fiorot Júnior
authors.forename: André Carvalho
authors.initials: AC
authors.lastname: Felício
authors.forename: Márcia Mauimi
authors.initials: MM
authors.lastname: Fukujima
authors.forename: Celso Arraes
authors.initials: CA
authors.lastname: Rodrigues
authors.forename: Vânia Maria
authors.initials: VM
authors.lastname: Morelli
authors.forename: Dayse Maria
authors.initials: DM
authors.lastname: Lourenço
authors.forename: Gilmar Fernandes do
authors.initials: GF
authors.lastname: Prado
mesh_terms: D000328:Adult; D006801:Humans; D020767:Intracranial Thrombosis / Q000382:microbiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D020306:Tuberculosis, Central Nervous System / Q000150:complications*; D020246:Venous Thrombosis / Q000382:microbiology*
chemical_list: D011516:Prothrombin