title: Gastric small cell carcinoma with marked response to neoadjuvant chemotherapy.
abstract: We report a patient with gastric small cell carcinoma (SCC) who showed a marked response to neoadjuvant chemotherapy. The patient was a 72-year-old Japanese man who was admitted because of epigastralgia. Subsequent examination revealed the presence of advanced gastric carcinoma in the lesser curvature of the lower body of the stomach, with multiple abdominal lymph node metastases. Endoscopic biopsy specimens from the tumor revealed SCC with moderately differentiated adenocarcinoma. The patient received neoadjuvant chemotherapy consisting of carboplatin (400 mg/m2, for 1 day), epirubicin (27 mg/m2, for 1 day), etoposide (70 mg/m2, for 3 days), and 5-fluorouracil (330 mg/m2, for 11 days). Clinically, the primary tumor and lymph node metastases were markedly reduced. Subsequently the patient underwent curative surgery and was alive without recurrence for more than 3 years after the surgery.
authors.affiliation: Department of Pathology, Tohoku Graduate University School of Medicine, 2-1 Seiryo-machi, Sendai 980-8575, Japan. nakamura@patholo2.med.tohoku.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Setsuya
authors.initials: S
authors.lastname: Otani
authors.forename: Michiro
authors.initials: M
authors.lastname: Otaka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shimada
authors.forename: Satsuki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.forename: Tohru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Masahumi
authors.initials: M
authors.lastname: Komatsu
authors.forename: Toshie
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shunji
authors.initials: S
authors.lastname: Okubo
authors.forename: Masato
authors.initials: M
authors.lastname: Hayashi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery