title: Interdigital involvement in a case of primary cutaneous canine histoplasmosis in Japan.
abstract: A 5-year-old male Siberian husky bred outdoor in Tokyo had a swollen paw with interdigital granulomatous lesions in the left hindlimb. The dog had no apparent pulmonary or gastrointestinal involvement. Histopathological analysis of the skin lesions demonstrated yeast-like organisms predominantly within macrophages. Sequence analysis of fungal ribosome RNA gene isolated from a paraffin sample revealed a 100% homology with the teleomorph of Histoplasma capsulatum. The present case may support the concept of primary cutaneous canine histoplasmosis as an endemic phenotype recognized in Japan.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo160-8582.
authors.forename: K
authors.initials: K
authors.lastname: Nishifuji
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: A
authors.initials: A
authors.lastname: Sano
authors.forename: M
authors.initials: M
authors.lastname: Kadoya
authors.forename: K
authors.initials: K
authors.lastname: Kamei
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001483:Base Sequence; D004271:DNA, Fungal / Q000032:analysis* / Q000737:chemistry; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D006614:Hindlimb / Q000473:pathology; D006658:Histoplasma / Q000235:genetics / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D007564:Japan; D008297:Male; D008969:Molecular Sequence Data; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal