[Preparation of silymarin proliposomes and its pharmacokinetics in rats].
OBJECTIVE
To study the preparation of silymarin proliposomes. To study its physicochemic properties, its pharmacokinetical characteristics and bioavailability in rats after oral administration.


METHODS
Silymarin proliposomes were prepared by film-deposition on carriers. When the proliposomes were contacted with water to form liposome suspensions, the tests of physicochemical properties including encapsulation efficiency, particle size and stability of the formed liposome suspensions were determined by HPLC, laser-particle-sizer and etc. The concentrations of non-conjugated and overall silymarin in plasma of rats and their pharmacokinetic behaviors after oral administration were studied by RP-HPLC. The pharmacokinetic parameters were computed by software program 3P97.


RESULTS
The encapsulation efficiency of silymarin liposomes could be more than 90%, with an average particle size of about 238.8 nm and a very good stability. The high bioavailability of silymarin proliposomes could be gotten by oral administration.


CONCLUSIONS
Compared with silymarin, silymarin proliposome is a stable and easily industrialized preparation and did enchance the gastrointestinal absorption of silymarin.
Xiao
Yan-yu
YY
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Song
Yun-mei
YM
Chen
Zhi-peng
ZP
Ping
Qi-neng
QN
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004337:Drug Carriers; D004355:Drug Stability; D008081:Liposomes; D008297:Male; D020944:Silybum marianum / Q000737:chemistry; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012838:Silymarin / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D013678:Technology, Pharmaceutical / Q000379:methods
D004337:Drug Carriers; D008081:Liposomes; D012838:Silymarin