Structural characteristics of lysophosphatidic acid biological targets.
Lysophosphatidic acid (LPA; 1-acyl-3-phosphoglycerol) exerts its biological activity through both extracellular and intracellular targets. Receptor targets include the cell-surface G-protein-coupled receptors LPA(1-4) and the nuclear PPAR-gamma (peroxisome-proliferator-activated receptor gamma). Enzyme targets include the secreted cancer cell motility factor, autotaxin, and the transmembrane phosphatases, LPP1-3 (where LPP stands for lipid phosphate phosphatase). Ion channel targets include the two pore domain ion channels in the TREK family, TREK-1, TREK-2 and TRAAK. Structural features of these targets and their interactions with LPA are reviewed.
Parrill
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AL
Department of Chemistry and Computational Research on Materials Institute (CROMIUM), The University of Memphis, Memphis, TN 38152, USA. aparrill@memphis.edu
D000595:Amino Acid Sequence; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D047495:PPAR gamma / Q000378:metabolism; D024683:Potassium Channels, Tandem Pore Domain / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D020033:Protein Isoforms / Q000378:metabolism; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism; D016415:Sequence Alignment
D008246:Lysophospholipids; D047495:PPAR gamma; D024683:Potassium Channels, Tandem Pore Domain; D020033:Protein Isoforms; D049368:Receptors, Lysophosphatidic Acid; C103742:potassium channel protein TREK-1; C032881:lysophosphatidic acid