Regulation of temporal identities during Drosophila neuroblast lineage development.
One of the major goals of neurobiology is to describe, in molecular terms, how a neural progenitor cell can generate an ordered series of uniquely fated neurons and glia. It has become clear that many, or all, neural-subtype identities can be linked to sequentially changing regulatory programs within neural precursors. Recent studies shed light on regulatory inputs and timing mechanisms that generate temporally defined cell identities, and new contributions are beginning to establish a link between the temporal network and cell function.
Brody
Thomas
T
Neural Cell-Fate Determinants Section, NINDS, NIH, Bethesda, Maryland, USA. brodyt@ninds.nih.gov
Odenwald
Ward F
WF
D000818:Animals; D019070:Cell Lineage / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology*; D004330:Drosophila / Q000166:cytology / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D009474:Neurons / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*