title: Discriminant analysis to study trace elements in biomonitoring: an application on neurodegenerative diseases.
abstract: Quantification of 26 elements was performed in blood of patients affected by neurodegenerative pathologies, i.e., Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS), and of a control group to study the potential role of blood elements as markers for the different neurodegenerations. A multivariate discriminant analysis (stepwise method) was applied to determine the best set of variables to discriminate among subjects with different health status. Preliminary results show three classification functions of seven elements, namely Ca, Co, Cu, Fe, Ni, Pb and Zr.
authors.affiliation: Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Pino
authors.forename: Sonia
authors.initials: S
authors.lastname: Brescianini
authors.forename: Cristina
authors.initials: C
authors.lastname: D'Ippolito
authors.forename: Corrado
authors.initials: C
authors.lastname: Fagnani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Stazi
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood; D016002:Discriminant Analysis; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood; D019636:Neurodegenerative Diseases / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood; D014131:Trace Elements / Q000097:blood*
chemical_list: D014131:Trace Elements