Granulocytic adhesive interactions and their role in sickle cell vaso-occlusion.
Recent research has high-lighted the importance of leukocytes in sickle cell disease (SCD). Here we summarize evidence to show that the granulocytes may play a role in SCD due to their increased numbers and adhesive properties, facilitating their participation in the vaso-occlusive process.
Canalli
Andreia Averci
AA
Hematology and Hemotherapy Center, State University of Campinas-UNICAMP, Brazil. andreiaa.c@uol.com.br
Costa
Fernando Ferreira
FF
Saad
Sara T O
ST
Conran
Nicola
N
D000755:Anemia, Sickle Cell / Q000150:complications / Q000378:metabolism*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D014652:Vascular Diseases / Q000209:etiology / Q000378:metabolism*
D015815:Cell Adhesion Molecules