Pleomorphic carcinoma of the lung with mediastinal extension following malignant lymphoma: report of a case.
In following up a patient with non-Hodgkin's lymphoma, we encountered a case of pulmonary pleomorphic carcinoma with mediastinal direct invasion. A 65-year-old man with hemoptysis was found to have an abnormal shadow in the right upper lung field. A 6.4 x 4.8-cm tumor adjacent to the upper mediastinum occupied the right anterior segment of the upper lobe (S3) and invaded the superior vena cava (SVC). The serum level of neuron-specific enolase was elevated to 11.9 ng/ml. A specimen from a transbronchial lung biopsy of the right B3b bronchus revealed giant tumor cells. A right upper lobectomy with SVC reconstruction was performed. The resected tumor was diagnosed as a pulmonary pleomorphic carcinoma with a large component of giant and spindle cells, and it is considered to be a rare histologic type.
Nakajima
Takahiro
T
Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Japan.
Iizasa
Toshihiko
T
Iyoda
Akira
A
Hiroshima
Kenzo
K
Yasufuku
Kazuhiro
K
Chiyo
Masako
M
Anayama
Takashi
T
Suzuki
Hidemi
H
Shibuya
Kiyoshi
K
Ohwada
Hidemi
H
Fujisawa
Takehiko
T
D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018286:Carcinoma, Giant Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000175:diagnosis; D019043:Vascular Neoplasms / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D014683:Vena Cava, Superior