title: Small-bowel perfusion measurement: feasibility with single-compartment kinetic model applied to dynamic contrast-enhanced CT.
abstract: This study was institutional review board approved and HIPAA compliant. Informed consent was obtained from all patients. The purpose of the study was to prospectively examine the feasibility of measuring small-bowel quantitative blood flow by using motion-corrected, contrast-enhanced computed tomographic (CT) images and a single-compartment kinetic model. Seven patients underwent abdominal CT in which 40 10-mm-thick sections were obtained at a single level. Small-bowel images were obtained every 3 seconds after contrast agent administration. Automated application of regions of interest yielded time-enhancement curves for the bowel wall and the aorta. A one-compartment model was applied to each set of time-enhancement curves for determination of the small-bowel volumetric blood flow F(V), volume of distribution V(D), and blood transit time tau. F(V) was also calculated by using the first-pass method and gamma variate analysis for model validation. The F(V) values obtained by using the single-compartment model (mean F(V), 0.47 min(-1)) showed excellent linear correlation with those obtained by using the first-pass method (Pearson r = 0.80) and gamma variate analysis (Pearson r = 0.97). Mean V(D) and tau values were 2.86 (unitless) and 4.28 seconds, respectively. A one-compartment kinetic model can be applied to motion-corrected, contrast-enhanced small-bowel CT images to quantify perfusion.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Sitek
authors.forename: Robert G
authors.initials: RG
authors.lastname: Sheiman
mesh_terms: D001783:Blood Flow Velocity; D003287:Contrast Media / Q000008:administration & dosage; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D007421:Intestine, Small / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012984:Software; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014283:Triiodobenzoic Acids / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C054871:ioversol