title: Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells.
abstract: The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 microg ml(-1))-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1beta and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 microg ml(-1 )inhibited the LPS-induced increase in the transcription of IL-1beta and iNOS and nitric oxide (NO) production in a dose-dependent manner.
authors.affiliation: Laboratory of Veterinary Pharmacology & Toxicology, College of Veterinary Medicine, Kyungpook National University, 702-701, Daegu, Republic of Korea.
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Hwang
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Lim
authors.forename: Hyo-In
authors.initials: HI
authors.lastname: Yun
authors.forename: Man-Hee
authors.initials: MH
authors.lastname: Rhee
authors.forename: Jae-Youl
authors.initials: JY
authors.lastname: Cho
authors.forename: Walter H
authors.initials: WH
authors.lastname: Hsu
authors.forename: Seung-Chun
authors.initials: SC
authors.lastname: Park
mesh_terms: D000818:Animals; D001412:Bacillus subtilis / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects*; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000235:genetics; D055666:Lipopeptides; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis* / Q000235:genetics; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D007375:Interleukin-1; D055666:Lipopeptides; D008070:Lipopolysaccharides; D010456:Peptides, Cyclic; C009365:surfactin peptide; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse