title: Effect of polycyclic cage amines on the transmembrane potential of neuronal cells.
abstract: A series of pentacycloundecylamine derivatives were synthesized and their influence on the transmembrane potential of human SH-SY5Y neuroblastoma cells was evaluated using laser scanning confocal microscopy in combination with the potentiometric dye tetramethylrhodamine methyl ester. Results indicate that these derivatives influence the profile of KCl-induced membrane depolarization and cause an overall reduction in cell membrane depolarization.
authors.affiliation: Department of Pharmaceutical Chemistry, North-West University, Potchefstroom, South Africa.
authors.forename: Erika
authors.initials: E
authors.lastname: Grobler
authors.forename: Anne
authors.initials: A
authors.lastname: Grobler
authors.forename: Cornelis J
authors.initials: CJ
authors.lastname: Van der Schyf
authors.forename: Sarel F
authors.initials: SF
authors.lastname: Malan
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003500:Cyclization; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines