title: Coronary artery atherosclerosis is related to reduced regional left ventricular function in individuals without history of clinical cardiovascular disease: the Multiethnic Study of Atherosclerosis.
abstract: OBJECTIVE
  We investigated whether regional coronary calcium score by computed tomography is related to regional left ventricular systolic function measured by MRI tagging in participants of the Multiethnic Study of Atherosclerosis.
  
  
  RESULTS
  The Multiethnic Study of Atherosclerosis is a prospective observational study of men and women without a history of previous heart disease from 4 ethnic groups. Calcium scores were measured separately for the left anterior descendent (LAD), left circumflex (LCX), and right (RCA) coronary arteries. Left ventricular strain and strain rate were determined by tagged MRI in the corresponding vascular territories of the coronary vessels in 509 participants. Greater coronary calcification in the LAD, LCX, and right RCA coronary arteries were related to worse function in their respective perfusion. Anterior wall strain rate was -1.37+/-0.41 when LAD calcium was zero versus -1.17+/-0.24 1/s in the highest quartile of calcium score (P<0.001). Similar relationships were evident in the LCX and RCA regions. Participants with 1- and 2-vessel coronary artery calcium had better myocardial function in the remote area compared with the territory supplied by the diseased artery.
  
  
  CONCLUSIONS
  High-local calcium score is related to regional dysfunction in the corresponding coronary territory among individuals without a history of previous heart disease. These results indicate a link between atherosclerosis and subclinical regional left ventricular dysfunction.
authors.affiliation: Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287-0409, USA.
authors.forename: Thor
authors.initials: T
authors.lastname: Edvardsen
authors.forename: Robert
authors.initials: R
authors.lastname: Detrano
authors.forename: Boaz D
authors.initials: BD
authors.lastname: Rosen
authors.forename: J Jeffrey
authors.initials: JJ
authors.lastname: Carr
authors.forename: Kiang
authors.initials: K
authors.lastname: Liu
authors.forename: Shenghan
authors.initials: S
authors.lastname: Lai
authors.forename: Steven
authors.initials: S
authors.lastname: Shea
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.forename: João A C
authors.initials: JA
authors.lastname: Lima
mesh_terms: D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002114:Calcinosis / Q000208:ethnology / Q000473:pathology / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000208:ethnology* / Q000473:pathology / Q000503:physiopathology*; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology; D005006:Ethnicity; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000208:ethnology* / Q000473:pathology / Q000503:physiopathology*; D044465:White People
chemical_list: D002118:Calcium