Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after the double failure of hematopoietic stem cell transplantation.
An 11-year-old boy with severe chronic active Epstein-Barr virus infection (CAEBV) underwent successful cord blood transplantation (CBT) after consecutive failure of peripheral blood and bone marrow transplantation from his HLA-mismatched mother. CB cells from an unrelated donor were infused after conditioning with total body irradiation (12 Gy), melphalan (120 mg/m(2)), and etoposide (600 mg/m(2)). Complete remission without circulating EBV-DNA has continued for 15 months after a delayed hematologic recovery. This is the first successful report of CBT for CAEBV. CB may therefore be an alternate source of stem cells for the curative treatment of CAEBV, despite the absence of EBV-specific cytotoxic T lymphocytes.
Ishimura
Masataka
M
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ohga
Shouichi
S
Nomura
Akihiko
A
Toubo
Taikai
T
Morihana
Eiji
E
Saito
Yusuke
Y
Nishio
Hisanori
H
Ide
Makoto
M
Takada
Hidetoshi
H
Hara
Toshiro
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D020031:Epstein-Barr Virus Infections / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods*; D017211:Treatment Failure; D014916:Whole-Body Irradiation