Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice.
The anticonvulsant activities of Crocus sativus stigma constituents, safranal and crocin, were evaluated in mice using pentylenetetrazole (PTZ)-induced convulsions in mice. Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice from death. Crocin (200 mg/kg, i.p.) did not show anticonvulsant activity.
Hosseinzadeh
Hossein
H
Pharmaceutical Research Center, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir
Talebzadeh
Fatemeh
F
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D027622:Crocus / Q000737:chemistry; D053138:Cyclohexenes; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013729:Terpenes / Q000494:pharmacology*
D000927:Anticonvulsants; D053138:Cyclohexenes; D013729:Terpenes; D002338:Carotenoids; C087963:safranal; C029036:crocin; D010433:Pentylenetetrazole