title: Fast-melting tablets based on highly plastic granules.
abstract: Highly plastic granules that can be compressed into tablets at low pressure were developed to make fast-melting tablets (FMTs) by compression method. The highly plastic granules are composed of three components: a plastic material, a material enhancing water penetration, and a wet binder. One of the unique properties of the highly plastic granules is that they maintain a porous structure even after compression into tablets. The porous and plastic nature of the granules allows fast absorption of water into the compressed tablet for fast melting/dissolution of the tablet. The prepared tablets possess tablet strength and friability that are suitable for multi-tablet packages. The three-component highly plastic granules provide an effective way of making FMTs by compression.
authors.affiliation: Akina Inc., West Lafayette, IN 47906, USA.
authors.forename: Yourong
authors.initials: Y
authors.lastname: Fu
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients; D006244:Hardness; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010539:Permeability; D010969:Plastics / Q000737:chemistry*; D011208:Powders; D012995:Solubility; D013607:Tablets; D014867:Water / Q000737:chemistry
chemical_list: D005079:Excipients; D010969:Plastics; D011208:Powders; D013607:Tablets; D014867:Water