Effects of Erigeron breviscapus ethanol extract on neuronal oxidative injury induced by superoxide radical.
Antioxidant activity of the ethanol extract of Erigeron breviscapus (EEEB) were studied by using neuron oxidative injury model induced by superoxide radical. EEEB at the dose of 10-140 mug/ml reduced significantly the lipid peroxidation levels and lactic dehydrogenase (LDH) release from neuron exposed to superoxide radical (generated by xanthine and xanthine oxidase). These results suggest that neuroprotective actions of EEEB may be due to its antioxidant or radical scavenging activity.
Liu
Hong
H
Department of Pharmacy, Wuhan General Hospital, 627 Wuluo Road, Wuhan 430070, PR China. honguil@263.net
Yang
Xianliang
X
Ren
Tang
T
Feng
Yundian
Y
Xu
Huibi
H
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D049919:Erigeron; D045022:Lactate Dehydrogenases / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013481:Superoxides
D000975:Antioxidants; D010936:Plant Extracts; D013481:Superoxides; D045022:Lactate Dehydrogenases