title: Response of integrated biomarkers of fish (Lateolabrax japonicus) exposed to benzo[a]pyrene and sodium dodecylbenzene sulfonate.
abstract: Fish Lateolabrax japonicus were exposed to 0.1 and 1mg/L of anion surfactant sodium dodecylbenzene sulfonate (SDBS) and to 2 and 20 microg/L of benzo[a]pyrene (B[a]P) for 6, 12, and 18 days, with control and solvent control groups. Liver antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and glutathione S-transferase (GST), were determined; brain acetylcholinesterase (AChE) and liver inducible nitric oxide synthase (iNOS) activities were also measured. The results indicated that (1) L. japonicus avoided oxidative damage through antioxidant systems; (2) SOD, GPx, and GSH were induced, and GST was inhibited and then induced by B[a]P exposure; and (3) CAT, GPx, and AChE were induced while iNOS was inhibited, and GST was induced and then inhibited by SDBS stress in experimental period.
authors.affiliation: Key Laboratory of Marine Ecology and Environmental Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Jifa
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Yu
authors.forename: Song
authors.initials: S
authors.lastname: Xiuxian
authors.forename: Wang
authors.initials: W
authors.lastname: You
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001492:Bass / Q000378:metabolism*; D001557:Benzenesulfonates / Q000493:pharmacokinetics / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000493:pharmacokinetics / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D001557:Benzenesulfonates; D015415:Biomarkers; D014874:Water Pollutants, Chemical; D001564:Benzo(a)pyrene; C001114:dodecylbenzenesulfonic acid