[The expression of COX-1 and COX-2 following brain injuries].
Cyclooxygenase (COX) is the obligate, rate-limiting enzyme for the conversion of arachidonic acid into prostaglandins, which mediate mitogenesis, apoptosis, angiogenesis, blood flow, secondary injury, and inflammation. COX is consist of 2 subtypes: COX-1 and COX-2. In recent years, there are a number of lines of evidence that COX-1 and COX-2 play a important in role brain injuries.
Guo
Xue-rong
XR
Faculty of Forensic Medicine, Huazhong University of Science & Technology, Wuhan 430030, China.
Zhou
Yi-wu
YW
Ma
Yi-lie
YL
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D016861:Cyclooxygenase Inhibitors; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2