title: [Successful treatment with continuous infusion of coagulation factor concentrates in severe hemophilia A complicated with mixed trauma, crush syndrome and acute renal failure].
abstract: Treatment method of hemophilia with continuous infusion of clotting factor concentrates is not widespread. We report our experience with the use of continuous infusion of factor VIII in patient with mixed trauma, crush syndrome and acute renal failure. Patient was successfully treated with fasciotomy of left upper arm and forearm, 6 procedures of hemodialysis, 34.500 units of clotting factor VIII concentrate, and 13 red blood cells units. Our experience confirms the safety, efficiency, and economy of the method of the constant infusion of clotting factor concentrates for hemophilia patient requiring replacement therapy, surgical intervention, and hemodialysis.
authors.affiliation: Clinic of Hematology, Kaunas University of Medicine, Kaunas, Lithuania. hema@takas.lt
authors.forename: Rasa
authors.initials: R
authors.lastname: Griniūte
authors.forename: Rolandas
authors.initials: R
authors.lastname: Gerbutavicius
authors.forename: Vidas
authors.initials: V
authors.lastname: Pilvinis
authors.forename: Algimantas
authors.initials: A
authors.lastname: Pamerneckas
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000628:therapy; D000328:Adult; D003444:Crush Syndrome / Q000150:complications* / Q000628:therapy; D005169:Factor VIII / Q000008:administration & dosage*; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009104:Multiple Trauma / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005169:Factor VIII