Two new antioxidant stilbene dimers, parthenostilbenins A and B from Parthenocissus tricuspidata.
The ethyl acetate fraction of an aqueous alcoholic extract from the stem of Parthenocissus tricuspidata yielded 11 known compounds (1-11) and two new stilbene dimers parthenostilbenins A (12) and B (13) upon purification either by preparative TLC or reversed phase HPLC. The structures of the new isolates were identified using a combination of FAB-MS and NMR. These compounds were assessed for antioxidant activities in three different bioassay systems. Among them, piceatannol showed the strongest inhibitory activity in these assay systems. Two new compounds, parthenostilbenins A (12) and B (13) inhibited lipid peroxidation (IC (50) = 20.35 +/- 1.22 and 18.68 +/- 0.51 microg/mL, respectively) in a rat liver homogenate.
Kim
Hyoung Ja
HJ
Division of Life Sciences, Korea Institute of Science and Technology, Cheongryang, Seoul, Korea.
Saleem
Muhammad
M
Seo
Seon Hee
SH
Jin
Changbae
C
Lee
Yong Sup
YS
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D027844:Vitaceae
D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D010936:Plant Extracts; D013267:Stilbenes; C004931:1,1-diphenyl-2-picrylhydrazyl