title: Normal and transforming functions of RUNX1: a perspective.
abstract: Converging studies from many investigators indicate that RUNX1 has a critical role in the correct maintenance of essential cellular functions during embryonic development and after birth. The discovery that this gene is also frequently mutated in human leukemia has increased the interest in the role that RUNX1 plays in both normal and transforming pathways. Here, we provide an overview of the many roles of RUNX1 in hematopoietic self-renewal and differentiation and summarize the information that is currently available on the many mechanisms of RUNX1 deregulation in human leukemia.
authors.affiliation: Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Fady M
authors.initials: FM
authors.lastname: Mikhail
authors.forename: Kislay K
authors.initials: KK
authors.lastname: Sinha
authors.forename: Yogen
authors.initials: Y
authors.lastname: Saunthararajah
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Nucifora
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit