title: Portopulmonary hypertension: hemodynamics, pulmonary angiography, and configuration of the heart.
abstract: BACKGROUND
  The goal of the present study was to examine the cardiac configuration and pulmonary vascular changes in patients with portopulmonary hypertension (PPHTN) and compare them with those of idiopathic pulmonary arterial hypertension (IPAH).
  
  
  RESULTS
  The subjects were 10 patients with PPHTN and 18 with IPAH. In PPHTN, the increases in the right ventricular end-diastolic volume index (89+/-19 vs 128+/-50 ml/m2; p=0.04), right end-systolic volume index (50+/-19 vs 95+/-47 ml/m 2; p=0.02) and right ventricular mass index (47+/-18 g/m2 vs 79+/-31; p=0.04) were low compared with IPAH. The decrease in the right ventricular ejection fraction was also low in PPHTN (45+/-10 vs 28+/-13%; p=0.01). The degree of sparse arborization and abrupt narrowing on wedged pulmonary angiography was moderate in PPHTN compared with IPAH. In PPHTN, the proximal pulmonary arteries were dilated near the segmental arteries, which were narrow in IPAH.
  
  
  CONCLUSIONS
  Changes in the configuration of the heart were moderate in PPHTN compared with those in IPAH. The degree of sparse arborization and abrupt narrowing were also moderate in PPHTN.
authors.affiliation: Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine,Sendai, Japan. sakuma@cardio.med.tohoku.ac.jp
authors.forename: Masahito
authors.initials: M
authors.lastname: Sakuma
authors.forename: Shinko
authors.initials: S
authors.lastname: Souma
authors.forename: Osamu
authors.initials: O
authors.lastname: Kitamukai
authors.forename: Jun
authors.initials: J
authors.lastname: Demachi
authors.forename: Tohru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Suzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Nawata
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Sugimura
authors.forename: Minako
authors.initials: M
authors.lastname: Oikawa
authors.forename: Kenya
authors.initials: K
authors.lastname: Saji
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tada
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Fukui
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kagaya
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
authors.forename: Kunio
authors.initials: K
authors.lastname: Shirato
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000000981:diagnostic imaging*; D013318:Stroke Volume; D014055:Tomography, Emission-Computed / Q000379:methods