Synthesis of some new 1,3/ or 1,4-bis(glucopyranosyl-1,2,4-triazol-5-ylthio)propanes/ or butanes as potential antimicrobial agents.
Glucosidation of the appropriate 1,3 or 1,4-bis(4-amino or arylideneamino-2,4-dihydro-3-thioxo-3H-1,2,4-triazol-5-ylthio)propanes or butanes with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide followed by chromatographic separation gave the corresponding N-, S-, and N,S-bis(glucosides). Chemical transformation leading to new functionalities has been achieved. Antimicrobial screening of 10 selected compounds resulted in their activity against Aspergillus fumigatus, Penicillium italicum, Syncephalastrum racemosum, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.
Abbas
Ashraf A
AA
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Khalil
Nasser S A M
NS
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001671:Biochemistry / Q000379:methods*; D002073:Butanes / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D011407:Propane / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014230:Triazoles / Q000737:chemistry
D000890:Anti-Infective Agents; D002073:Butanes; D005960:Glucosides; D014230:Triazoles; D011407:Propane