title: [In vitro transdermal permeation of lidocaine-dodecanol binary eutectic system].
abstract: OBJECTIVE
  To study the effect of lidocaine-dodecanol binary eutectic system on the transdermal permeation of lidocaine.
  
  
  METHODS
  Binary eutectic mixture of different proportions of lidocaine and dodecanol were prepared and the patch containing the binary eutectic mixture was developed. The solubilities of pure lidocaine and lidocaine from the binary eutectic system were determined in pH 7.9 phosphate buffer. The transdermal flux of lidocaine from the patches containing the binary eutectic system and pure lidocaine were measured using Franz-type single diffusion cell.
  
  
  RESULTS
  The melting point of the lidocaine-dodecanol binary eutectic system was markedly lower than that of pure lidocaine. The steady state transdermal flux of lidocaine from the patch of the binary eutectic system was six times as much as that of pure lidocaine patch.
  
  
  CONCLUSIONS
  The lidocaine-dodecanol binary eutectic system could produce high thermodynamic activity of the drug and the high driving force for transdermal permeation of lidocaine.
authors.affiliation: College of Science, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Guang-ming
authors.initials: GM
authors.lastname: Ke
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Wan-liang
authors.initials: WL
authors.lastname: Lu
authors.forename: Shu-ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Hong-you
authors.initials: HY
authors.lastname: Guo
mesh_terms: D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D007851:Dodecanol / Q000008:administration & dosage* / Q000737:chemistry; D004338:Drug Combinations; D004355:Drug Stability; D006168:Guinea Pigs; D008012:Lidocaine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D012869:Skin Absorption; D012995:Solubility
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D007851:Dodecanol; D008012:Lidocaine