Lipid peroxidation and trace elements in systemic sclerosis.
Oxidative stress appears to be important in the causation and perpetuation of tissue injury and fibrosis in systemic sclerosis or scleroderma (SSc). We conducted a case-control study to assess lipid peroxidation levels as determined by measuring fasting plasma malondialdehyde (MDA) and serum levels of the trace elements selenium, iron, zinc and copper in SSc. Plasma MDA levels were almost tenfold higher in patients than in controls (p=0.00007), and an inverse relationship between MDA levels and disease duration (r=-0.52, p=0.044) was observed. Selenium levels were lower in patients than in controls (p=0.012). Within the patient cohort, copper correlated inversely with the total skin score (r=-0.52, p=0.03). Our findings provide further evidence that lipid peroxidation is increased and antioxidant capacity is reduced in SSc. The gradual decline in MDA levels with time suggests that antioxidant therapy, if to be useful in SSc, is most likely to be effective early in the course of the disease.
Tikly
Mohammed
M
Department of Medicine, Division of Rheumatology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, P.O. Berstham 2013, Johannesburg, South Africa. tiklym@medicine.wits.ac.za
Channa
Kalavati
K
Theodorou
Penny
P
Gulumian
Mairam
M
D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D006304:Health Status; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D012595:Scleroderma, Systemic / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D012867:Skin / Q000473:pathology; D011795:Surveys and Questionnaires; D013997:Time Factors; D014131:Trace Elements / Q000097:blood*
D014131:Trace Elements; D008315:Malondialdehyde