title: Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation.
abstract: Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2alpha concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2alpha produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction.
authors.affiliation: Department of Experimental Pathology, William Harvey Research Institute, St Bartholomew's & Royal London School of Medicine & Dentistry, Charterhouse Square, London EC1M 6BQ, UK. Paul.Colville-Nash@epsom-sthelier.nhs.uk
authors.forename: Paul R
authors.initials: PR
authors.lastname: Colville-Nash
authors.forename: Derek W
authors.initials: DW
authors.lastname: Gilroy
authors.forename: Dean
authors.initials: D
authors.lastname: Willis
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Paul-Clark
authors.forename: Adrian R
authors.initials: AR
authors.lastname: Moore
authors.forename: Derek A
authors.initials: DA
authors.lastname: Willoughby
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000633:toxicity; D015237:Dinoprost / Q000096:biosynthesis*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D009578:Nitrobenzenes / Q000494:pharmacology / Q000633:toxicity; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000494:pharmacology / Q000633:toxicity
chemical_list: D016861:Cyclooxygenase Inhibitors; D009578:Nitrobenzenes; D011461:Prostaglandins F, Synthetic; D011982:Receptors, Prostaglandin; D013449:Sulfonamides; C034671:prostaglandin F2alpha receptor; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; C006326:fluprostenol; D015237:Dinoprost; D051546:Cyclooxygenase 2