title: [Effect of the pre-hospital systematic treatment on prognosis patients of with severe acute organophosphorus pesticide poisoning].
abstract: OBJECTIVE
  To investigate if the duration from poisoning to treatment (no treatment period) is related to the prognosis of patients with severe acute organophosphorus pesticide poisoning (SAOPP).
  
  
  METHODS
  One hundred and seventy-four patients with the pre-hospital systematic treatment served as the treatment group while 160 patients going to the hospital by themselves without treatment or rejecting gastrolavage served as the control group. Patients in both groups were treated by gastrolavage, pralidoxime chloride, atropine and other expectant treatment. The duration of no treatment period, death, and severe complication were observed. The time of disappearance of symptoms, the recovery time of acetyl cholinesterase (AChE), atropinization time, atropine dosage, pralidoxime chloride dosage, naloxone dosage, hospitalization days and other targets were also observed.
  
  
  RESULTS
  The duration of no treatment period in treatment group [(1.2 +/- 0.3) h] was significantly shorter than that in control group [(2.8 +/- 0.5) h, (P < 0.01)]. The mortality rate in treatment group was 6.32% while that in control group 22.5% (P < 0.01). The incidence of respiratory failure, heart injury, brain injury, atropine poisoning, intermediate syndrome, liver injury in treatment group (12.64%, 5.75%, 8.62%, 1.72%, 4.60%, 5.17% respectively) were lower than those in control group (25.63%, 13.75%, 17.50%, 6.25%, 7.50%, 9.38% respectively, P < 0.05 or P < 0.01). The time of symptoms disappearance, the recovery time of AChE, atropinization time, atropine dosage, pralidoxime chloride dosage, naloxone dosage, hospitalization days in treatment group were significantly superior to those in control group (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  The pre-hospital systematic treatment can improve the prognosis of the patients with SAOPP, which is worth popularizing and using.
authors.affiliation: Emergency Department, Harrison International Peace Hospital, Hengshui, Hebei Province 053000, China.
authors.forename: Wei-zhan
authors.initials: WZ
authors.lastname: Wang
authors.forename: Ya-qin
authors.initials: YQ
authors.lastname: Li
authors.forename: Jian-zhi
authors.initials: JZ
authors.lastname: Zhang
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Guo-ying
authors.initials: GY
authors.lastname: Ma
authors.forename: Shuang-qing
authors.initials: SQ
authors.lastname: Cao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008297:Male; D062025:Organophosphate Poisoning; D010575:Pesticides / Q000506:poisoning*; D011379:Prognosis
chemical_list: D007306:Insecticides; D010575:Pesticides