title: Quantification of the effects of melittin on liposome structure.
abstract: An optical technique, dual-polarization interferometry, has been used to examine lipid structures at the solid/liquid interface. Changes in the lipid structures, in real time, were examined as a consequence of challenging them with a peptide (melittin) that is known to induce liposome rupture. This work suggests that it should be possible to obtain a better understanding of the detail of the melittin rupture process.
authors.affiliation: Farfield Sensors Ltd, Unit 51, Salford University Business Park, Salford, Greater Manchester M6 6AJ, UK.
authors.forename: J
authors.initials: J
authors.lastname: Popplewell
authors.forename: N
authors.initials: N
authors.lastname: Freeman
authors.forename: S
authors.initials: S
authors.lastname: Carrington
authors.forename: G
authors.initials: G
authors.lastname: Ronan
authors.forename: C
authors.initials: C
authors.lastname: McDonnell
authors.forename: R C
authors.initials: RC
authors.lastname: Ford
mesh_terms: D005454:Fluorescence Polarization; D008051:Lipid Bilayers; D008081:Liposomes / Q000737:chemistry*; D008555:Melitten / Q000737:chemistry*; D010713:Phosphatidylcholines
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D008555:Melitten; C017251:1,2-oleoylphosphatidylcholine