Synthesis of the C6-C21 segment of amphidinolide E.
[reaction: see text] A convergent approach to a C6-C21 segment of the polyketide amphidinolide E has been developed through combination of three subunits by allenylindium bromide-aldehyde addition and Suzuki sp2-sp3 coupling.
Marshall
James A
JA
Department of Chemistry, University of Virginia, P.O. Box 400319, Charlottesville, Virginia 22904, USA. jam5x@virginia.edu
Schaaf
Gregory
G
Nolting
Andrew
A
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000097442:Amphidinolides
D019086:Bridged Bicyclo Compounds, Heterocyclic; D018942:Macrolides; C452448:amphidinolide E; D000097442:Amphidinolides