title: Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by small cell lung carcinoma.
abstract: We report a 75-year-old man who developed herpes simplex encephalitis (HSE), presenting with bilateral hippocampal lesions on magnetic resonance imaging, and this case was simultaneously complicated by small cell lung carcinoma. We identified a new anti-neuronal antibody in the cerebrospinal fluid of this patient. Our findings suggest that HSE and paraneoplastic limbic encephalitis (PLE) can overlap, and we discuss the relationships of HSE, PLE, and related disorders.
authors.affiliation: First Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Hirai
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Ayabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shoji
authors.forename: Masahide
authors.initials: M
authors.lastname: Kaji
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichiyama
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000368:Aged; D000818:Animals; D001323:Autoantibodies / Q000134:cerebrospinal fluid; D018288:Carcinoma, Small Cell / Q000150:complications*; D002531:Cerebellum / Q000276:immunology; D020803:Encephalitis, Herpes Simplex / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D066298:In Vitro Techniques; D020363:Limbic Encephalitis / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology
chemical_list: D001323:Autoantibodies; D009419:Nerve Tissue Proteins