Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase.
A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series.
Laporte
M G
MG
ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, PA 19341, USA. mlaporte@gentara.net
Lessen
T A
TA
Leister
L
L
Cebzanov
D
D
Amparo
E
E
Faust
C
C
Ortlip
D
D
Bailey
T R
TR
Nitz
T J
TJ
Chunduru
S K
SK
Young
D C
DC
Burns
C J
CJ
D018938:Caco-2 Cells; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000201:enzymology*; D006801:Humans; D008956:Models, Chemical; D017434:Protein Structure, Tertiary; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry* / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase