title: Total synthesis of reblastatin.
abstract: Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramolecular Buchwald-like amidation reaction to close the 19-membered macrolactam.
authors.affiliation: Department of Chemistry, Boston University, Boston, Massachusetts 02215, USA.
authors.forename: Iwona E
authors.initials: IE
authors.lastname: Wrona
authors.forename: Ana E
authors.initials: AE
authors.lastname: Gabarda
authors.forename: Gwilherm
authors.initials: G
authors.lastname: Evano
authors.forename: James S
authors.initials: JS
authors.lastname: Panek
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D008956:Models, Chemical; D011809:Quinones / Q000138:chemical synthesis*
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011809:Quinones; C414123:reblastatin