[Advances in the study on molecular mechanism for maintaining the undifferentiated state of embryonic stem cells].
Embryonic stem cells (ES cells), that are derived from the inner cell mass (ICM) of early embryos at the blastocyst stage, have the ability of self-renewal and multiple differentiation capacity. Now ES cells have been extensively applied in basic research and clinical application. That ES cells maintain their undifferentiated state during culture is the prerequisite and basis of their application, and therefore it is necessary to elucidate the molecular mechanism. This review summarized the latest progress in the study on the molecular mechanism for maintaining the undifferentiated state of embryonic stem cells, and emphasized the function of differentiation suppression factors such as LIF, Oct-3/4 and Nanog.
Du
Juan
J
Institute of Reproduction and Stem Cell Engineering, Xiangya Medical College, Central South University, Changsha, Hunan 410078, China.
Lu
Guang-Xiu
GX
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D053605:Leukemia Inhibitory Factor / Q000378:metabolism*; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3 / Q000378:metabolism; D015398:Signal Transduction
D018398:Homeodomain Proteins; D053605:Leukemia Inhibitory Factor; C486780:NANOG protein, human; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3