title: [Russian photosensitizer radachlorine in photodynamic therapy for epibulbar and choroid tumors: experimental studies].
abstract: The authors used the Russian agent Radachlorine as a photosensitizer (PS) in photodynamic therapy (PDT) for epibulbar and chorioid tumors. Analyzing the results suggests that the efficacy of Radachlorine used as PS in a correctly adjusted dose in PDT may be high. The optimization of effects in the experiment was observed when Radachlorine was used in a dose of 3 mg/kg with a light radiation dose of 500 mW/cm2 upon 5-min exposure. However, a rapid relapse in some cases indicates the instability of the effect and makes it necessary to make repeated PS injections and PDT sessions.
authors.forename: S E
authors.initials: SE
authors.lastname: Avetisov
authors.forename: V G
authors.initials: VG
authors.lastname: Likhvantseva
authors.forename: A V
authors.initials: AV
authors.lastname: Reshetnikov
authors.forename: A A
authors.initials: AA
authors.lastname: Fedorov
authors.forename: M V
authors.initials: MV
authors.lastname: Vereshchagina
authors.forename: M L
authors.initials: ML
authors.lastname: Balaian
authors.forename: R N
authors.initials: RN
authors.lastname: Krupnov
mesh_terms: D000818:Animals; D002735:Chlorophyllides; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005451:Fluorescein Angiography; D008297:Male; D008546:Melanoma, Experimental / Q000175:diagnosis / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011166:Porphyrins / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D011829:Radiation Dosage; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002735:Chlorophyllides; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin