title: Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.
abstract: In order to improve the oral bioavailability of 2-C-methylcytidine, a potent anti-HCV agent, the corresponding 3'-O-L-valinyl ester derivative (NM 283) has been synthesized Based on its ease of synthesis and its physicochemical properties, NM 283 has emerged as a promising antiviral drug for treatment of chronic HCV infection.
authors.affiliation: Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, Montpellier Cedex 5, France.
authors.forename: C
authors.initials: C
authors.lastname: Pierra
authors.forename: S
authors.initials: S
authors.lastname: Benzaria
authors.forename: A
authors.initials: A
authors.lastname: Amador
authors.forename: A
authors.initials: A
authors.lastname: Moussa
authors.forename: S
authors.initials: S
authors.lastname: Mathieu
authors.forename: R
authors.initials: R
authors.lastname: Storer
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003841:Deoxycytidine / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008956:Models, Chemical; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011355:Prodrugs; D011741:Pyrimidine Nucleosides; D003841:Deoxycytidine; C506207:valopicitabine