Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease.
A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD.
Meier
Andreas
A
Department of Psychiatry and Psychotherapy, Sleep Disorders Center, Georg-August-University, von-Siebold-Strasse 5, 37075 Goettingen, Germany. ameier2@gwdg.de
Mollenhauer
Brit
B
Cohrs
Stefan
S
Rodenbeck
Andrea
A
Jordan
Wolfgang
W
Meller
Johannes
J
Otto
Markus
M
D015415:Biomarkers / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D011237:Predictive Value of Tests
D015415:Biomarkers; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins