Autism spectrum disorders associated with X chromosome markers in French-Canadian males.
It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.
Gauthier
J
J
Centre Hospitalier de l'Université de Montréal, Research Centre, Notre Dame Hospital, Montreal, QC, Canada.
Joober
R
R
Dubé
M-P
MP
St-Onge
J
J
Bonnel
A
A
Gariépy
D
D
Laurent
S
S
Najafee
R
R
Lacasse
H
H
St-Charles
L
L
Fombonne
E
E
Mottron
L
L
Rouleau
G A
GA
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002170:Canada; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics; D002675:Child, Preschool; D002874:Chromosome Mapping; D041321:Chromosomes, Human, X / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree
D005819:Genetic Markers