Acute myeloid leukemia with concurrent myeloid sarcoma treated with autologous bone marrow transplantation: two illustrative cases and a literature review.
Myeloid sarcoma (MS) is an invasive extramedullary solid tumor composed of immature cells of the myeloid series. It complicates the clinical course of a minority of patients with acute myeloid leukemia (AML). Traditionally its presence has been regarded as an indicator of aggressive disease. Currently, the optimal treatment of AML with concurrent MS remains to be determined. We report two cases of autologous bone marrow transplantation (auto-BMT) for AML with concurrent MS followed by a review of the literature.
Finnegan
D P J
DP
Department of Hematology, Belfast City Hospital, Belfast, Northern Ireland. dfinnegan2@doctors.org.uk
Jones
F G C
FG
McMullin
M F
MF
D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008113:Liver Neoplasms / Q000628:therapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000150:complications / Q000628:therapy*; D018410:Pneumonia, Bacterial / Q000150:complications; D012008:Recurrence; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000150:complications / Q000628:therapy*; D013290:Streptococcal Infections / Q000150:complications; D013899:Thoracic Neoplasms / Q000150:complications / Q000628:therapy*; D014182:Transplantation, Autologous