The insulin-like growth factor system: IGFs, IGF-binding proteins and IGFBP-proteases.
Insulin-like growth factors (IGF-I/-II) are not only the endocrine mediators of growth hormone-induced metabolic and anabolic actions but also polypeptides that act in a paracrine and autocrine manner to regulate cell growth, differentiation, apoptosis and transformation. The IGF system is a complex network comprised of two growth factors (IGF-I and -II), cell surface receptors (IGF-IR and -IIR), six specific high affinity binding proteins (IGFBP-I to IGFBP-6), IGFBP proteases as well as several other IGFBP-interacting molecules, which regulate and propagate IGF actions in several tissues. Besides their broad-spectrum physiological and pathophysiological functions, recent evidence suggests even a link between IGFs and different malignancies.
Lelbach
A
A
2nd Department of Internal Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Muzes
Gy
G
Feher
J
J
D000375:Aging / Q000502:physiology; D000818:Animals; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology*; D008666:Metalloendopeptidases / Q000502:physiology; D011266:Pregnancy-Associated Plasma Protein-A / Q000502:physiology; D017526:Receptor, IGF Type 1 / Q000502:physiology; D017527:Receptor, IGF Type 2 / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D013002:Somatomedins / Q000502:physiology*
D018969:Insulin-Like Growth Factor Binding Proteins; D017527:Receptor, IGF Type 2; D013002:Somatomedins; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin; D010450:Endopeptidases; C095329:IGFBP-2 protease; D008666:Metalloendopeptidases; D011266:Pregnancy-Associated Plasma Protein-A