Myogenic stem cells: regeneration and cell therapy in human skeletal muscle.
Human skeletal muscle has been considered as an ideal target for cell-mediated therapy. However, the positive results obtained in dystrophic animal models using the resident precursor satellite cell population have been followed by discouraging evidences obtained in the clinical trials involving Duchenne muscular dystrophy patients. This text reviews the recent advances that many groups have achieved to identify from the stem cell compartment putative candidates for cell therapy. We focused our attention on stem cells with myogenic potential which might be able to improve transplantation efficiency and therefore could be used as a therapeutic tool for neuromuscular diseases.
Negroni
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Cytosquelette et Développement, FRE 2853, Faculté de Médecine Pitié-Salpétrière, Université Pierre et Marie Curie, 105, boulevard de l'Hôpital, 75013 Paris, France.
Butler-Browne
G S
GS
Mouly
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V
D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D006801:Humans; D008938:Mitosis; D023421:Models, Animal; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology*; D009135:Muscular Diseases / Q000628:therapy*; D032446:Myoblasts / Q000637:transplantation; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*