An analysis on gene architecture in human and mouse genomes.
A comparative genome analysis on exon-intron distribution profiles is performed for human and mouse genomes to deduce similarities and differences between them. Interestingly, both in human and mouse genomes, the total length in introns and intergenic DNA on each chromosome is significantly correlated to the chromosome size. The results presented provide a framework for understanding the nature and patterns of exon-intron length distributions, the constraints on them and their role in genome design and evolution.
Sakharkar
Meena Kishore
MK
Nanyang Centre for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798. mmeena@ntu.edu.sg
Perumal
Bagavathi S
BS
Sakharkar
Kishore R
KR
Kangueane
Pandjassarame
P
D000818:Animals; D002875:Chromosomes / Q000235:genetics; D021901:DNA, Intergenic; D019143:Evolution, Molecular; D005091:Exons; D015894:Genome, Human; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
D021901:DNA, Intergenic