title: Glucose-stimulated insulin response in non-diabetic patients with lipoprotein lipase deficiency and hypertriglyceridemia.
abstract: Elevations in plasma triglyceride (TG) and free fatty acid (FFA) concentrations are generally thought to play a role in the pathogenesis of insulin-resistant diabetes. The objective of this study was to investigate the relationship between hypertriglyceridemia and glucose-stimulated insulin responsiveness in non-diabetic patients. Forty subjects were divided into three BMI-matched groups as follows: one group consisted of 8 patients with a lipoprotein lipase (LPL) deficiency, another consisted of 12 patients with hypertriglyceridemia and a third consisted of 20 subjects with normal TG levels. In response to a 75 g oral glucose tolerance test, plasma insulin levels in the LPL-deficient subjects were higher (106+/-11 microU/ml) than those in the hypertriglyceridemic (69+/-16 microU/ml) and normolipidemic (29+/-3 microU/ml) subjects, at 30 min. On the other hand, their plasma glucose levels (127+/-6 mg/dl) were less than those seen in the normolipidemic group (165+/-9 mg/dl) after 90 min. Thus, LPL-deficient subjects with hypertriglyceridemia displayed an enhanced glucose-stimulated insulin response as well as lower blood glucose levels, the latter of which is not generally seen in those with hypertriglyceridemia and normolipidemia.
authors.affiliation: Third Department of Internal Medicine, Hirosaki University School of Medicine, Zaifu-5, Hirosaki, Aomori 036-8562, Japan. tmsw@cc.hirosaki-u.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Tamasawa
authors.forename: Jun
authors.initials: J
authors.lastname: Matsui
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murakami
authors.forename: Jutaro
authors.initials: J
authors.lastname: Tanabe
authors.forename: Kohta
authors.initials: K
authors.lastname: Matsuki
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Takagi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suda
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000503:physiopathology*; D007328:Insulin / Q000097:blood*; D008071:Lipoprotein Lipase / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D008071:Lipoprotein Lipase