Recombination between the dfrA12-orfF-aadA2 cassette array and an aadA1 gene cassette creates a hybrid cassette, aadA8b.
Homologous recombination between closely related gene cassettes, such as aadA1 and aadA2, which are 89% identical, can create hybrid cassettes and hybrids of existing cassette arrays. A new cassette array, dfrA12-orfF-aadA8b, which was created by such a recombination event occurring within the aadA2 cassette in the dfrA12-orfF-aadA2 array, has been identified.
Gestal
Alicia M
AM
Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia.
Stokes
H W
HW
Partridge
Sally R
SR
Hall
Ruth M
RM
D001483:Base Sequence; D004722:Endoribonucleases / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009713:Nucleotidyltransferases / Q000235:genetics*; D011995:Recombination, Genetic
D029968:Escherichia coli Proteins; D009713:Nucleotidyltransferases; C020565:gentamicin 2''-nucleotidyltransferase; D004722:Endoribonucleases; C081905:rng protein, E coli