Apolipoprotein E genotype in matched men and women with coronary heart disease.
Apolipoprotein E (apo E) plays an important role in lipid metabolism and its polymorphism may be a risk determinant of coronary heart disease (CHD). Since evidence suggested a gender-specific effect of apo E polymorphism, we studied the influence of gender-specific interaction of the polymorphism on CHD. From a total of 463 Greek Caucasians (314 men and 149 postmenopausal women) with angiographically documented CHD, we selected 79 women (68+/- 9 yr old) and 79 men (66+/- 9 yr old) who were matched for clinical characteristics. Apo E genotyping was performed by PCR and RFLP analysis. Biochemical parameters were also measured. The results were as follows: the E3/3 genotype occurred in 78.5% of the patients, followed by E3/4, E2/3, E2/4, and E4/4 genotypes, which occurred in 9.5%, 9.5%, 1.9%, and 0.6% of the patients, respectively. No significant differences were observed in the apo E allele or apo E genotype distributions between the matched Greek men and women with CHD. The E3/3 men patients were more frequently part of a family with a history of CHD, compared to women (p=0.035).
Kolovou
Genovefa D
GD
Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece. genkolovou@mail.gr
Anagnostopoulou
Katherine K
KK
Salpea
Klelia D
KD
Panagiotakos
Demosthenes B
DB
Hoursalas
Ioannis S
IS
Cariolou
Marios A
MA
Koniavitou
Katerina
K
Cokkinos
Dennis V
DV
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D017698:Postmenopause; D012737:Sex Factors; D044465:White People
D001057:Apolipoproteins E