title: Synthesis of new artemisinin-derived dimers by self-cross-metathesis reaction.
abstract: [reaction: see text] New artemisinin-derived dimers, fluorinated or not, have been prepared by a self-cross metathesis reaction in the presence of first- or second-generation ruthenium catalysts without degradation of the endoperoxide bridge and with a good E/Z selectivity (up to 100:0).
authors.affiliation: CNRS-BIOCIS, Faculté de Pharmacie Paris XI, rue J. B. Clément, 92296 Châtenay-Malabry, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Grellepois
authors.forename: Benoit
authors.initials: B
authors.lastname: Crousse
authors.forename: Danièle
authors.initials: D
authors.lastname: Bonnet-Delpon
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bégué
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin