Recombinant polymers for cancer gene therapy: a minireview.
A major challenge for successful cancer gene therapy is the development of safe and effective gene delivery vectors. Gene delivery vectors can be viral or nonviral. Among nonviral vectors various polymeric vectors have shown potential in gene delivery. However, much work needs to be done in order to correlate polymer structure with gene release at the target site and transfection efficiency. This article is a brief introduction into cancer gene therapy, barriers and methods for gene transfer with emphasis on the applications of recombinant polymers for cancer gene therapy.
Haider
M
M
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, 21201, USA.
Hatefi
A
A
Ghandehari
H
H
D000595:Amino Acid Sequence; D000818:Animals; D003692:Delayed-Action Preparations; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D011994:Recombinant Proteins