title: Human brain derived cell culture models of HIV-1 infection.
abstract: During the clinical course of acquired immune deficiency syndrome, infection of the CNS by human immunodeficiency virus-1 (HIV-1) may ultimately result in the impairment of cognitive, behavioral and motor functions. Viral neuropathogenesis involves inflammatory molecules and neurotoxins produced from infected and immune-activated lymphocytes, microglial cells and astrocytes. Here, we discuss the current understanding of HIV-1 infection of the CNS and various cell culture systems from the developing human brain in order to study the neurobiology of HIV-1 infection, the mechanisms contributing to HIV-1 infection, and disease progression.
authors.affiliation: Molecular and Cellular Neuroscience, National Brain Research Centre, Manesar, India.
authors.forename: P
authors.initials: P
authors.lastname: Seth
authors.forename: E O
authors.initials: EO
authors.lastname: Major
mesh_terms: D015526:AIDS Dementia Complex / Q000473:pathology*; D001921:Brain / Q000166:cytology* / Q000473:pathology*; D002478:Cells, Cultured; D015658:HIV Infections / Q000473:pathology*; D015497:HIV-1; D006801:Humans; D013234:Stem Cells / Q000473:pathology / Q000821:virology