Cytotoxic phenylpropanoid glycosides from the stems of Smilax china.
Bioassay-guided fractionation of an ethanol extract of Smilax china led to the isolation of nine phenylpropanoids including six new compounds, smilasides A-F (1-6), and three known phenylpropanoids, smiglaside E, heloniosides B, and 2',6'-diacetyl-3,6-diferuloylsucrose. Structural elucidation of isolates 1-6 was based on spectroscopic data analysis. These new phenylpropanoids were evaluated against several human tumor cell lines.
Kuo
Yao-Haur
YH
National Research Institute of Chinese Medicine, Taipei, 112 Taiwan, Republic of China. kuoyh@nricm.edu.tw
Hsu
Ya-Wen
YW
Liaw
Chia-Ching
CC
Lee
Jiun Kuan
JK
Huang
Hui-Chi
HC
Kuo
Li-Ming Yang
LM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032281:Smilax / Q000737:chemistry*; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D020005:Propanols