title: Derivatives of tramadol for increased duration of effect.
abstract: Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.
authors.affiliation: Sepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. liming.shao@sepracor.com
authors.forename: Liming
authors.initials: L
authors.lastname: Shao
authors.forename: Craig
authors.initials: C
authors.lastname: Abolin
authors.forename: Michael C
authors.initials: MC
authors.lastname: Hewitt
authors.forename: Patrick
authors.initials: P
authors.lastname: Koch
authors.forename: Mark
authors.initials: M
authors.lastname: Varney
mesh_terms: D000701:Analgesics, Opioid / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D001665:Binding Sites; D003061:Codeine / Q000737:chemistry / Q000627:therapeutic use; D008956:Models, Chemical; D009020:Morphine / Q000737:chemistry / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy; D051381:Rats; D013997:Time Factors; D014147:Tramadol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol; D009020:Morphine; D003061:Codeine