L-nucleosides containing modified nucleobases.
The synthesis of base modified L-nucleosides is described with pyrrolo[2,3-d]pyrimidines, pyrazolo[3,4-d]pyrimidines, benzimidazoles, and imidazo[1,2-a]-s-triazines as nucleobases. The conformation of the nucleosides is studied and the antiviral activity is evaluated.
Seela
Frank
F
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
Lin
W
W
Kazimierczuk
Z
Z
Rosemeyer
H
H
Glaron
V
V
Peng
X
X
He
Y
Y
Ming
X
X
Andrzejewska
M
M
Gorska
A
A
Zhang
X
X
Eickmeier
H
H
La Colla
P
P
D000998:Antiviral Agents / Q000494:pharmacology; D001482:Base Composition; D001562:Benzimidazoles / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018360:Crystallography, X-Ray; D015195:Drug Design; D006031:Glycosylation; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D014227:Triazines / Q000737:chemistry; D014965:X-Rays
D000998:Antiviral Agents; D001562:Benzimidazoles; D009705:Nucleosides; D011687:Purines; D011743:Pyrimidines; D014227:Triazines; C015008:triazolopyrimidinone; C031000:benzimidazole