title: QT interval prolongation and torsade de pointes associated with indapamide.
abstract: Direct blockade of the delayed rectifier repolarising potassium current is the major underlying mechanism of drug-induced QT interval prolongation. Indapamide is a well known blocker of the slow component of the delayed rectifier current leading to prolongation of cardiac repolarization. The case of an acquired long QT and torsade de pointes ventricular tachycardia in a woman with systemic lupus erythematosus and hypertension receiving prednisolone and indapamide, respectively, is described in the present report.
authors.forename: Konstantinos P
authors.initials: KP
authors.lastname: Letsas
authors.forename: Ioannis P
authors.initials: IP
authors.lastname: Alexanian
authors.forename: Loukas K
authors.initials: LK
authors.lastname: Pappas
authors.forename: Stavros P
authors.initials: SP
authors.lastname: Kounas
authors.forename: Michalis
authors.initials: M
authors.lastname: Efremidis
authors.forename: Antonios
authors.initials: A
authors.lastname: Sideris
authors.forename: Fotis
authors.initials: F
authors.lastname: Kardaras
mesh_terms: D000328:Adult; D004232:Diuretics / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007190:Indapamide / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology; D016171:Torsades de Pointes / Q000139:chemically induced*; D014693:Ventricular Fibrillation / Q000139:chemically induced
chemical_list: D004232:Diuretics; D007190:Indapamide