title: Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines.
abstract: Eight 5-alkynyl-2'deoxyuridines containing different bulky substituents have been prepared and tested against HSV-1 in Vero cells. The compounds show positive antiviral activity. There is no obvious correlation between activity and substituent size. The nature of the linker between uracil and a substituent appears to be more important for antiviral properties: nucleosides containing arylethynyl groups show higher activity.
authors.affiliation: Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Pchelintseva
authors.forename: M V
authors.initials: MV
authors.lastname: Skorobogatyj
authors.forename: A L
authors.initials: AL
authors.lastname: Petrunina
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: I V
authors.initials: IV
authors.lastname: Astakhova
authors.forename: A V
authors.initials: AV
authors.lastname: Ustinov
authors.forename: A D
authors.initials: AD
authors.lastname: Malakhov
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Korshun
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002522:Chlorocebus aethiops; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D008956:Models, Chemical; D018139:Simplexvirus / Q000378:metabolism*; D014498:Uracil / Q000737:chemistry; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D014498:Uracil; D003857:Deoxyuridine