Comparative conformational analysis of nucleosides by NMR, X-ray, and semi-empirical (PM3 VS. AM1) methods.
The 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl ortho-aza-purine and -pyrimidine nucleosides manifest an unusually rigid sugar N conformation in solution.
Mikhailopulo
Igor A
IA
Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, Kuopio 70211, Finland.
Sokolov
Yuri A
YA
He
Junlin
J
Chittepu
Padmaja
P
Rosemeyer
Helmut
H
Seela
Frank
F
D001087:Arabinonucleosides / Q000737:chemistry; D055592:Biophysical Phenomena; D001703:Biophysics; D002241:Carbohydrates / Q000737:chemistry; D018360:Crystallography, X-Ray / Q000379:methods; D004247:DNA / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013816:Thermodynamics
D001087:Arabinonucleosides; D002241:Carbohydrates; D009711:Nucleotides; D012313:RNA; D004247:DNA