title: Study on the supramolecular interaction of thiabendazole and beta-cyclodextrin by spectrophotometry and its analytical application.
abstract: The beta-cyclodextrin-thiabendazole (beta-CD-TBZ) inclusion complex was synthesized and its structure characterized by (1)H NMR and IR. The mechanism of the supramolecular interaction of TBZ and beta-CD has been studied and discussed by spectrophotometry. The results showed that the phenyl ring of TBZ was included in the beta-CD cavity to form a 1:1 host-guest complex with an apparent formation constant of 1.60 x 10(3) mol(-1).L. On the basis of the enhancement of the absorbance of TBZ produced through complex formation, a spectrophotometric method for the determination of TBZ in bulk aqueous solution in the presence of beta-CD was developed. The linear relationship between the absorbance and TBZ concentration was obtained in the range of 8.86 x 10(-7)-1.45 x 10(-5) mol/L. The detection limit was 2.71 x 10(-7)mol/L, and the relative standard deviation was 0.86%. The interference of 48 coexisting substances was slight. The proposed method has been successfully applied to the determination of TBZ in fruits with recoveries of 96-103%.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Huiling
authors.initials: H
authors.lastname: Liang
authors.forename: Baoxiu
authors.initials: B
authors.lastname: Jia
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Chen
mesh_terms: D002021:Buffers; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D013827:Thiabendazole / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D002021:Buffers; D047392:beta-Cyclodextrins; C031215:betadex; D013827:Thiabendazole