title: Diagnostic yield of closed pleural brushing.
abstract: The aim of this study was to assess the diagnostic yield of closed pleural brushing (CPBR) in the diagnosis of malignant pleural effusion. Twenty-one adult patients (20 men and 1 woman); aged 62.9 +/- 8.6 were participated to this prospective study. Thoracentesis, CPBR and closed pleural biopsy (CPB) following the brushing were applied to every patient. While CPBR provided diagnosis in 12 (57.1%) of 21 cases, in 3 of these 12 cases, pleural fluid cytology (PFC) and CPB were negative. The sensitivities of PFC, CPBR and CPB in the diagnosis of malignant effusions were 33%, 57% and 52%, respectively. When three procedures were used in combination, the sensitivity increased to 67%. When CPBR is performed in addition to PFC and CPB, the yield of the diagnosis increased 14% additionally. There was no mortality due to these interventions. Complications were chest pain in 3 (14.2%) cases, hypotension in 2 (9.5%) cases, cough in 1 (4.8%) case, pneumothorax in 1 (4.8%) case, and hemothorax in 1 (4.8%) case. In conclusion, CPBR as a safe, simple and well tolerated procedure provides high diagnostic yield in diagnosis of patients with malignant pleural effusion.
authors.affiliation: Department of Chest Disease, Süreyyapaşa Chest and Cardiovascular Disease Education and Research Hospital, Istanbul, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Aksoy
authors.forename: Güliz
authors.initials: G
authors.lastname: Ataç
authors.forename: Tülin
authors.initials: T
authors.lastname: Sevim
authors.forename: Gökay
authors.initials: G
authors.lastname: Güngör
authors.forename: Tülay
authors.initials: T
authors.lastname: Törün
authors.forename: Emin
authors.initials: E
authors.lastname: Maden
authors.forename: Kemal
authors.initials: K
authors.lastname: Tahaoğlu
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000166:cytology / Q000473:pathology*; D016066:Pleural Effusion, Malignant / Q000175:diagnosis* / Q000473:pathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity