Interactions of the ergosterol biosynthetic pathway with other lipid pathways.
Micro-organisms have recently received broad attention as sources of novel lipids. An increased understanding of the effects of fats and oils and their composition on the metabolism and on health has shifted the focus towards the use of lipids for disease treatment and prevention and for the promotion of good health. A large range of lipidic products produced by yeast is known today. Ergosterol and its metabolic precursors are major lipidic components of industrial and commercial interest. Having in mind the aim to increase the productivity of ergosterol and its precursor metabolites, both the knowledge of regulatory mechanisms of the biosynthetic pathway and its interactions with other lipid pathways like those of sphingolipids, phospholipids and fatty acids are crucial.
Veen
M
M
Institut für Biotechnologie, Technische Universität Berlin, FG Mikrobiologie und Genetik, Gustav-Meyer-Allee 25, D-13355 Berlin, Germany.
Lang
C
C
D004875:Ergosterol / Q000096:biosynthesis*; D008055:Lipids / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000502:physiology
D008055:Lipids; D004875:Ergosterol