title: Severe allergic reactions to guinea pig.
abstract: BACKGROUND
  Allergic sensitization and reactions to guinea pig (Cavia porcellus) have been well documented in laboratory animal handlers, primarily manifesting as rhinitis, conjunctivitis, and asthma. Severe allergic reactions, however, are rare.
  
  
  METHODS
  We report two patients with severe allergic reactions following non-occupational exposure to guinea pigs. The first patient, an 11-year-old female, developed ocular, nasal, skin and laryngeal edema symptoms immediately after handling a guinea pig. The second patient, a 24-year-old female, developed symptoms of isolated laryngeal edema after cleaning a guinea pig cage. Percutaneous skin testing, RAST, ELISA and ELISA inhibition testing with guinea pig extract were performed.
  
  
  RESULTS
  Both patients had IgE-mediated allergy to guinea pig confirmed by ELISA and either RAST or skin testing. ELISA inhibition studies confirmed the specificity of the IgE reactivity to guinea pig.
  
  
  CONCLUSIONS
  Severe IgE-mediated reactions can occur following non-occupational guinea pig exposure. Physicians should be aware of this possibility.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. mzach@mcw.edu
authors.forename: Michael C
authors.initials: MC
authors.lastname: Zacharisen
authors.forename: Michael B
authors.initials: MB
authors.lastname: Levy
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Shaw
authors.forename: Viswanath P
authors.initials: VP
authors.lastname: Kurup