What else has to happen for nitric oxide to induce cell death?
Nitric oxide (NO) can induce cell death; however, NO-induced cell death may be dependent/conditional on factors other than NO itself. Whether NO kills a particular cell depends on the amount of NO, source of NO, time of exposure to NO, cell type and the levels of other factors including, particularly oxygen, superoxide, H2O2, antioxidants, thiols and glycolysis.
Borutaite
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V
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK. vb207@mole.bio.cam.ac.uk
Brown
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G
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism; D006019:Glycolysis / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism
D000975:Antioxidants; D016877:Oxidants; D013481:Superoxides; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D005978:Glutathione; D010100:Oxygen