[Experimental study of Oleanolic acid liquid acting on climacteric rats].
OBJECTIVE
To study whether the Oleanolic acid had curative effect on climacteric rats as an independent factor.


METHODS
The experimental group was administrated with Oleanolic acid, while the positive group was given with Isoflavniphytoestrogeno, and the climacteric model and adolescent control groups were fed with 0.9% saline water. The effect of Oleanolic acid on rats was observed. In each group the levels of serum E2, SOD, MDA, GSH-Px were tested, the morphology of ovary and adrenal cortex were also studied.


RESULTS
It was showed that Oleanolic acid could increase the levels of serum E2, SOD, GSH-Px (P < 0.05), decrease the level of MDA (P < 0.01) and improve the morphology and the functions of ovary and adrenal cortex.


CONCLUSIONS
It is concluded that Oleanolic acid has curative effect independently on climacteric rats.
Lou
Yan
Y
Nanfang Hospital, Southern Medical University, Guangzhou 510515.
Chen
Zhiliang
Z
Wang
Chunxia
C
D000302:Adrenal Cortex / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002979:Climacteric / Q000097:blood / Q000187:drug effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D031659:Ligustrum / Q000737:chemistry; D008315:Malondialdehyde / Q000097:blood; D009828:Oleanolic Acid / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood
D015415:Biomarkers; D004958:Estradiol; D008315:Malondialdehyde; D009828:Oleanolic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase