Advances in the synthesis and recent therapeutic applications of 1,2,4-thiadiazole heterocycles.
Chemical properties of 1,2,4-thiadiazole have been reviewed in the last few years. However, the usefulness of 1,2,4-thiadiazole as a privileged system in medicinal chemistry has prompted the advances on the therapeutic potential of this system. This review provides a brief summary of the medicinal chemistry of 1,2,4-thiadiazole system and highlights some examples of 1,2,4-thiadiazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 1,2,4-thiadiazole is presented in sections by generalized synthetic methods.
Castro
Ana
A
Instituto de Química Médica (CSIC), Juan de la Cierva 3, Madrid, Spain.
Castaño
Tania
T
Encinas
Arantxa
A
Porcal
Williams
W
Gil
Carmen
C
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008956:Models, Chemical; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects*; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use
D006571:Heterocyclic Compounds; D043562:Receptors, G-Protein-Coupled; D013830:Thiadiazoles