Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity.
The protective effect of tomato extract and lycopene on acute doxorubicin (DOX) myocardial toxicity was evaluated in mice. DOX toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by an elevated serum CPK(MB) and histopathological observations. Tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.) prevented the rise in serum CPK(MB) and ameliorated cardiac cell injury. These results suggest that tomato extract and lycopene inhibit DOX cardiotoxicity and might serve as a novel combination chemotherapeutic agent with DOX to limit free radical-mediated organ injury.
Karimi
Gholamreza
G
Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Gho_karimi@yahoo.com
Ramezani
Mohammad
M
Abdi
Azadeh
A
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D004317:Doxorubicin; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D016166:Free Radical Scavengers; D010936:Plant Extracts; D020011:Protective Agents; D002338:Carotenoids; D004317:Doxorubicin; D003402:Creatine Kinase; D000077276:Lycopene