title: [Clinical and pathological analysis of oral manifestations of 40 patients with secondary syphilis].
abstract: OBJECTIVE
  To analyze the clinical and pathological features of 40 patients with secondary syphilis.
  
  
  METHODS
  A total of 40 cases of secondary syphilis confirmed by serology were collected during 1994-2004 and were first diagnosed on presentation with oral lesions.
  
  
  RESULTS
  The white patch in oral mucosa was found in 32 cases with painless or slight pain in most cases. The most common site of the lesion was the tongue. The histological examination on eight cases was initially misdiagnosed as oral candidosis or lichen planus, but confirmed as syphilis after serology revealed nonspecific inflammation with intraepithelial microabscess and dense perivascular infiltration of lymphocytes and plasma cells in connective tissue. The symptoms showed dramatic improvement in 16 cases after benzathine penicillin treatment.
  
  
  CONCLUSIONS
  The oral manifestations of syphilis have specific clinical and pathological feature and attention should be paid to the suspicious oral lesions when patients are first presented in a dental office.
authors.affiliation: Deaprtment of Oral Medicine, Peking University School of Stomatology, Beijing 100081, China. honghua1968@yahoo.com.cn
authors.forename: Hong
authors.initials: H
authors.lastname: Hua
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Yan
authors.forename: Rui-tang
authors.initials: RT
authors.lastname: Shi
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.forename: Yan-ying
authors.initials: YY
authors.lastname: Xu
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D019226:Oral Ulcer / Q000209:etiology; D013587:Syphilis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*