title: [Stereoselective pharmacokinetics of tetrahydropalmatine in rats].
abstract: OBJECTIVE
  To investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.
  
  
  METHODS
  The concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.
  
  
  RESULTS
  The plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.
  
  
  CONCLUSIONS
  Tetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate.
authors.affiliation: Shanghai Key Laboratory for Pharmaceutical Metabolites Research, School of Pharmacy, Second Military Medical University PLA, Shanghai, China.
authors.forename: Zhan-Ying
authors.initials: ZY
authors.lastname: Hong
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Fan
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Chai
authors.forename: Jun
authors.initials: J
authors.lastname: Wen
authors.forename: Xue-Ping
authors.initials: XP
authors.lastname: Yin
authors.forename: Yu-Tian
authors.initials: YT
authors.lastname: Wu
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D031311:Corydalis / Q000737:chemistry; D005260:Female; D008297:Male; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
chemical_list: D001600:Berberine Alkaloids; C014215:tetrahydropalmatine