[Fibroblast growth factor (FGF)-23 in patients with hypoparathyroidism].
Hypoparathyroidism is a well-described cause of hyperphosphatemia. We aimed to clarify the physiological role of FGF-23 in serum phosphate homeostasis in hypoparathyroidism after thyroidectomy. Increased serum FGF-23 levels were found in patients with hyperphosphatemia and hypocalcemia, caused by hypoparathyroidism after thyroidectomy. After the recovery of parathyroid function, the serum level of calcium, phosphate, and FGF-23 was normalized. Serum FGF-23 levels were significantly higher in patients with permanent hypoparathyroidism than in healthy controls. These results indicate that FGF-23 may play an important role in serum phosphate homeostasis by its up-regulation in the hyperphosphatemic condition.
Yamashita
Hiroyuki
H
Noguchi Thyroid Clinic and Hospital Foundation.
Noguchi
Shiro
S
Yamasaki
Yuji
Y
Hasegawa
Hisashi
H
Yamashita
Takeyoshi
T
Fukumoto
Seiji
S
Shigematsu
Takashi
T
Kazama
Junichiro
J
Fukagawa
Masafumi
M
D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000209:etiology; D007011:Hypoparathyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood*; D010760:Phosphorus Metabolism Disorders / Q000097:blood / Q000209:etiology; D013965:Thyroidectomy / Q000009:adverse effects
C000717427:FGF23 protein, human; D010758:Phosphorus; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23