title: Pulmonary hypertension: classification and diagnostic algorithm.
abstract: Pulmonary arterial hypertension (PAH) is defined as a group of diseases characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and premature death. Recently, the diagnostic approach has been more clearly defined according to the new clinical classification and with consensus reached on algorithms of various investigative tests and procedures that exclude other causes and ensure an accurate diagnosis of PAH. The diagnostic procedures include clinical history and physical examination, ECG, chest X-ray, transthoracic Doppler echocardiography, pulmonary function tests, arterial blood gas analysis, ventilation and perfusion lung scan, high-resolution computed tomography of the lungs, contrast-enhanced spiral computed tomography of the lungs and pulmonary angiography, blood tests and immunology, abdominal ultrasound scan, exercise capacity assessment, and hemodynamic evaluation. Invasive and non-invasive markers of disease severity, either biomarkers or physiological parameters and tests that can be widely applied, have been proposed to reliably monitor the clinical course.
authors.affiliation: Institute of Cardiology, University of Bologna, Bologna, Italy. amanes@orsola-malpighi.med.unibo.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Manes
authors.forename: Carlo
authors.initials: C
authors.lastname: Campana
mesh_terms: D000465:Algorithms; D003952:Diagnostic Imaging / Q000379:methods*; D004562:Electrocardiography; D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification* / Q000175:diagnosis*; D011379:Prognosis; D012129:Respiratory Function Tests; D012720:Severity of Illness Index