Concentration of elements in serum of patients affected by multiple sclerosis with first demyelinating episode: a six-month longitudinal follow-up study.
Twenty-six chemical elements and oxidative status were determined in serum of 12 patients with first demyelinating episode and brain magnetic resonance imaging compatible with the disease at different time points. Quantifications of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, V, Tl, W, Zn and Zr, as well as of serum oxidative status and antioxidant capacity were carried out. The results were compared with values obtained from healthy subjects living in the same geographic area. Concentration variability, expressed as coefficient of variation (CV), was evaluated over a six months longitudinal follow-up. The CV was higher for Li and Pb, while showed minimal variation for Ca, Cu, Mg and Zn--elements strictly body regulated. Significant difference (p < or = 0.05) in mean concentrations of Ba, Ca, Cd, Cr, Li, Mn, Mo, Ni, Sb, Si, Sn and Zr between patients at time 0 and controls was also found.
Visconti
Andrea
A
Dipartimento di Neurologia, Ospedale S. Andrea, Università degli Studi La Sapienza, Rome, Italy.
Cotichini
Rodolfo
R
Cannoni
Stefania
S
Bocca
Beatrice
B
Forte
Giovanni
G
Ghazaryan
Anna
A
Santucci
Simone
S
D'Ippolito
Cristina
C
Stazi
Maria Antonietta
MA
Salvetti
Marco
M
Alimonti
Alessandro
A
Ristori
Giovanni
G
D000328:Adult; D000975:Antioxidants / Q000032:analysis; D015331:Cohort Studies; D003711:Demyelinating Diseases; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000097:blood*; D009103:Multiple Sclerosis / Q000097:blood*; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress; D012825:Silicon / Q000097:blood
D000975:Antioxidants; D008670:Metals; D016877:Oxidants; D012825:Silicon