Relapsing sensorimotor neuropathy with ophthalmoplegia, antidisialosyl antibodies, and extramembranous glomerulonephritis.
A 72-year-old man presented with oculomotor dysfunction, subacute relapsing sensorimotor neuropathy, elevated erythrocyte sedimentation rate, IgM monoclonal paraprotein, cold agglutinins, and antidisialosyl IgM antibodies, features previously described by the acronym CANOMAD (chronic ataxic neuropathy with ophthalmoplegia, M protein, agglutination, and disialosyl antibodies). The patient also had extramembranous glomerulopathy associated with this syndrome. Treatment with corticosteroids improved both the neuropathy and glomerulopathy. This case suggests that the spectrum of neuropathy associated with monoclonal gammopathy may be broader than originally believed.
Delval
Arnaud
A
Department of Neurology, CHRU de Lille, France.
Stojkovic
Tanya
T
Vermersch
Patrick
P
D000200:Action Potentials; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001799:Blood Sedimentation; D003450:Cryoglobulins / Q000032:analysis; D004576:Electromyography; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology; D008297:Male; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D009422:Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015840:Oculomotor Nerve Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D009886:Ophthalmoplegia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011597:Psychomotor Performance; D012008:Recurrence; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D003450:Cryoglobulins; D005732:Gangliosides; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein; C029443:cold agglutinins