Inflammatory granulocytes decrease subcutaneous growth of melanoma in mice.
Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5 x 10(5) melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.
Costa
Madalena M
MM
Department of Anatomy, ICBAS (Abel Salazar Institute for Biomedical Sciences) and UMIB (Unit for Multidisciplinary for Biomedical Research), University of Porto, Portugal, European Union. mcosta@icbas.up.pt
Aguas
Artur P
AP
D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D005122:Exudates and Transudates / Q000166:cytology / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D007279:Injections, Subcutaneous; D008546:Melanoma, Experimental / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D012878:Skin Neoplasms / Q000473:pathology*; D013997:Time Factors; D047368:Tumor Burden / Q000276:immunology
D012710:Serum Albumin, Bovine