Novel cytogenetic findings revealed by conventional cytogenetic and FISH analyses in leukaemia patients.
OBJECTIVE
To describe novel cytogenetic findings in four leukaemia patients.


METHODS
Conventional cytogenetic (CC) and fluorescence in situ hybridization (FISH) analyses were performed on bone marrow samples of four leukaemia patients.


RESULTS
In this study, t(3;10)(q11;q25) and t(2;22)(p21;q11.2) were detected as novel translocations. t(8;16;21)(q22.1;q13;q22) and t(1;6;9;22)(p36.1;p21.3;q34;q11) were found as variant translocations, and these variant translocations were confirmed by Interphase-FISH and Multi-colour-FISH.


CONCLUSIONS
Newly identified cytogenetic findings can lead us to characterize cytogenetic evolution of the haematological malignancies. Further investigations are certainly warranted to resolve the prognostic impact of these new cytogenetic abnormalities.
Karauzum
S B
SB
Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey. sibelkaruzum@akdeniz.edu.tr
Bilgen
T
T
Karadogan
I
I
Yakut
S
S
Cetin
Z
Z
Ugur
A
A
Luleci
G
G
D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic