title: Association of human herpesvirus type 6 DNA with human bladder cancer.
abstract: We examined the presence of human herpesvirus type 6 (HHV6) DNA in a series of 74 bladder carcinomas from a Mediterranean population to elucidate their possible role as cofactor in the development of bladder cancer with or without associated human papillomavirus (HPV) infection. HHV-6 type B DNA was present in 5 men (6.8%) out of the 74 tumors investigated; two of them had associated HPV-16 DNA in the same specimen. In one case that had associated urothelial carcinoma in situ, both HHV-6B and HPV-16 DNA were present. In conclusion, the low incidence of HHV-6B in bladder cancer and the ubiquitous nature of HHV-6 infection are more consistent with a bystander role rather than cofactor in the oncogenesis of bladder cancer.
authors.affiliation: Biomedical Research Unit, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain.
authors.forename: Alberto L
authors.initials: AL
authors.lastname: Escudero
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Luque
authors.forename: Ana
authors.initials: A
authors.lastname: Quintero
authors.forename: Jose
authors.initials: J
authors.lastname: Alvarez-Kindelan
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Requena
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics* / Q000472:pathogenicity*; D052162:Human papillomavirus 16 / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D008297:Male; D019083:Mediterranean Region; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications; D019349:Roseolovirus Infections / Q000150:complications*; D001749:Urinary Bladder Neoplasms / Q000821:virology*
chemical_list: D004279:DNA, Viral