title: Localized lesions on MRI in a case of hypertensive brainstem encephalopathy.
abstract: We report a case of hypertensive brainstem encephalopathy (HBE) with unusual magnetic resonance imaging (MRI) findings. A 67-year-old woman presented with high blood pressure and stupor as the only symptoms. MRI revealed lesions localized in the area from the upper medulla oblongata to the lower pons with high fluid-attenuated inversion recovery (FLAIR) and T2-weighted signal intensity, but these were not seen in the whole brainstem and there were no accompanying occipital lobe changes. To our knowledge, no similar case has been reported. The lesions and symptoms dramatically improved after normalization of blood pressure. Severe hypertension that exceeded the range of autoregulation may have resulted in segmental vasodilatation and the increased vascular permeability may have lead to vasogenic edema in the localized areas of the brainstem.
authors.affiliation: Department of Neurology, National Hospital Organization Okayama Medical Center, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ono
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Manabe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hamakawa
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Murakami
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Omori
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001933:Brain Stem / Q000473:pathology*; D005260:Female; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000959:Antihypertensive Agents