title: Life saving cyclophosphamide treatment in a girl with giant cell hepatitis and autoimmune haemolytic anaemia: case report and up-to-date on therapeutical options.
abstract: We report the case of a girl affected by giant cell hepatitis associated with autoimmune haemolytic anaemia. Both conditions were severe with a number of life-threatening episodes of liver failure and anaemia unresponsive to several immunosuppressant drugs but cyclophosphamide. After a low-dose long-term treatment with this drug the patient is stably well without any therapy. A review of therapeutical options in this condition is also presented.
authors.affiliation: Department of Pediatrics, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy. vajro@unina.it
authors.forename: P
authors.initials: P
authors.lastname: Vajro
authors.forename: F
authors.initials: F
authors.lastname: Migliaro
authors.forename: C
authors.initials: C
authors.lastname: Ruggeri
authors.forename: N
authors.initials: N
authors.lastname: Di Cosmo
authors.forename: G
authors.initials: G
authors.lastname: Crispino
authors.forename: M
authors.initials: M
authors.lastname: Caropreso
authors.forename: R
authors.initials: R
authors.lastname: Vecchione
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000188:drug therapy*; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006505:Hepatitis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone