title: New quinolone resistance phenomenon in Salmonella enterica: nalidixic acid-susceptible isolates with reduced fluoroquinolone susceptibility.
abstract: We describe the emergence of a new quinolone resistance pattern in Salmonella enterica isolates from Southeast Asia. These isolates are susceptible to nalidixic acid but exhibit reduced susceptibility to ciprofloxacin. The increase of such strains may threaten the value of the nalidixic acid disk test to screen for reduced fluoroquinolone susceptibility in salmonellas.
authors.affiliation: Antimicrobial Research Laboratory, National Public Health Institute, P.O. Box 57, 20521 Turku, Finland. antti.hakanen@utu.fi
authors.forename: Antti J
authors.initials: AJ
authors.lastname: Hakanen
authors.forename: Marianne
authors.initials: M
authors.lastname: Lindgren
authors.forename: Pentti
authors.initials: P
authors.lastname: Huovinen
authors.forename: Jari
authors.initials: J
authors.lastname: Jalava
authors.forename: Anja
authors.initials: A
authors.lastname: Siitonen
authors.forename: Pirkko
authors.initials: P
authors.lastname: Kotilainen
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D001208:Asia; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009268:Nalidixic Acid / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*; D012480:Salmonella Infections / Q000382:microbiology; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics; D014195:Travel
chemical_list: D000890:Anti-Infective Agents; D015363:Quinolones; D009268:Nalidixic Acid; D002939:Ciprofloxacin