Uncialamycin, a new enediyne antibiotic.
[structure: see text] Laboratory cultures of an undescribed streptomycete obtained from the surface of a British Columbia lichen produce uncialamycin (1), a new enediyne antibiotic. The structure of uncialamycin (1) has been elucidated by analysis of spectroscopic data. Uncialamycin (1) exhibits potent in vitro antibacterial activity against gram-positive and gram-negative human pathogens, including Burkholderia cepacia, a major cause of morbidity and mortality in patients with cystic fibrosis.
Davies
Julian
J
Life Sciences Institute, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
Wang
Hao
H
Taylor
Terry
T
Warabi
Kaoru
K
Huang
Xin-Hui
XH
Andersen
Raymond J
RJ
D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D016956:Burkholderia cepacia / Q000187:drug effects*; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C512009:uncialamycin