[Studies on hyaluronic acid as dendifier in Shuanghuanglian eye-drops].
OBJECTIVE
To study the possibility of hyaluronic acid as densifier of Shuanguangliao eye-drops.


METHODS
The factors related with hyaluronic acid s viscosity, such as pH-value and storing temperature, are tested in this experiment. At the same time, we checked the stimulation, stability of the densifier.


RESULTS
There was not effect on viscosity of pH-value and storing temperature. No stimulation on the eye was found after densified with hyaluronic acid. The viscosity properties of hyaluronic acid are stablile.


CONCLUSIONS
The hyaliuronic acid added to Shuanghuanglian eye-drops are stabiliable and it can be applied in eye-drops. The increased viscosity is benefit to extend the residence time of drug in eye.
Ma
Man-ling
ML
First Hospital of Harbin Medical University, Harbin 150001, China. mamanling@54dr.com
Liu
Lu
L
Sun
Shu-ying
SY
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D004337:Drug Carriers; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D005123:Eye / Q000187:drug effects; D005260:Female; D006820:Hyaluronic Acid / Q000494:pharmacology / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D013696:Temperature; D014783:Viscosity / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009883:Ophthalmic Solutions; D006820:Hyaluronic Acid