The direct alpha-zincation of amides, phosphonates and phosphine oxides by H-Zn exchange.
Stoichiometric or catalytic quantities of simple 2 degrees amines greatly increase the rate of H-Zn exchange between ZnPh2 and a range of relatively non-acidic substrates, allowing for the convenient and direct preparation of alpha-functionalized organozincs.
Hlavinka
Mark L
ML
Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA.
Greco
Jeffrey F
JF
Hagadorn
John R
JR