The effects of oxidative stress in urinary tract infection during pregnancy.
The purpose of this study was to determine the effect of urinary tract infection (UTI) on antioxidant systems and lipid peroxidation (LPO) levels during pregnancy. We also investigated if these antioxidant systems and LPO levels differed in each trimester. One hundred forty-three nonpregnant women, as a control group, and 77 pregnant women were included in the study. Urine cultures were performed according to standard techniques. Catalase (CAT), superoxide dismutase (SOD), and LPO levels were measured using a spectrophotometer. UTI was observed in 14 of 77 pregnant women and the isolated microorganisms were Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus. CAT, SOD, and LPO levels were increased in pregnant women compared with nonpregnant women (P<.01). CAT, SOD activities, and LPO levels were increased from the first trimester to the third trimester in pregnancy without UTI. However, CAT and SOD activities were decreased, LPO levels were increased from the first trimester to the third trimester in pregnancy with UTI (P<.01). Pregnancy causes oxidative stress and also UTI during pregnancy may aggravate oxidative stress.
Ciragil
Pinar
P
Department of Clinical Microbiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Turkey. pinarciragil@yahoo.com
Kurutas
Ergul Belge
EB
Gul
Mustafa
M
Kilinc
Metin
M
Aral
Murat
M
Guven
Alanur
A
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000652:urine*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000652:urine*; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism / Q000652:urine*; D012016:Reference Values; D013482:Superoxide Dismutase / Q000652:urine*; D014552:Urinary Tract Infections / Q000378:metabolism / Q000652:urine*
D000975:Antioxidants; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase