title: The alpha 2 type IX collagen gene tryptophan polymorphism is not associated with rheumatoid arthritis in the Japanese population.
abstract: The aim of this study was to investigate whether the alpha 2 type IX collagen (COL9A2) polymorphism that introduces tryptophan residue into the collagen triple-helix is a marker of susceptibility to, or severity of, rheumatoid arthritis (RA). The study included 749 Japanese patients with RA. One hundred twenty-four unrelated healthy individuals served as the control subjects. The relationship between the COL9A2 gene polymorphism and clinical manifestations of RA was evaluated. For the number of subjects positive for COL9A2 tryptophan polymorphism, there was no statistically significant difference between RA patients and normal controls. Furthermore, we did not detect any association of COL9A2 tryptophan polymorphism with disease status, least erosive subset, more erosive subset, or mutilating disease. The lack of association of COL9A2 tryptophan polymorphism with RA and the clinical findings in our study implies that the polymorphism may not function as a candidate gene marker for screening RA patients.
authors.affiliation: Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Takata
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Matsui
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hamada
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Goto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Egawa
authors.forename: Shunji
authors.initials: S
authors.lastname: Nakano
authors.forename: Fumio
authors.initials: F
authors.lastname: Shinomiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Itakura
authors.forename: Natsuo
authors.initials: N
authors.lastname: Yasui
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D024081:Collagen Type IX / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014364:Tryptophan / Q000235:genetics*
chemical_list: D024081:Collagen Type IX; D005819:Genetic Markers; D014364:Tryptophan