Enzymes in the biosynthesis of aromatic polyketide antibiotics.
Aromatic polyketides are secondary metabolites that afford some of the most common antibiotics and anti-cancer drugs currently in clinical use. Not least because of their medical importance, the biosynthesis of these compounds has attracted considerable interest during the past few years; important advances have been made in the structural and mechanistic characterisation of the enzymes involved. These studies are expected to have implications for the production of novel therapeutic agents by combinatorial biosynthesis.
Schneider
Gunter
G
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheele's väg 2, S-17177 Stockholm, Sweden. gunter.schneider@mbb.ki.se
D018943:Anthracyclines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*
D018943:Anthracyclines; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004798:Enzymes; D011084:Polycyclic Aromatic Hydrocarbons