title: Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides.
abstract: A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
authors.forename: Nanyan
authors.initials: N
authors.lastname: Fu
authors.forename: Qihan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lifang
authors.initials: L
authors.lastname: Duan
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Xu
mesh_terms: D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D019606:Phosphoamino Acids / Q000737:chemistry*; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D063065:Organophosphonates; D019606:Phosphoamino Acids; D010748:Phosphopeptides