title: L-nucleosides containing modified nucleobases.
abstract: The synthesis of base modified L-nucleosides is described with pyrrolo[2,3-d]pyrimidines, pyrazolo[3,4-d]pyrimidines, benzimidazoles, and imidazo[1,2-a]-s-triazines as nucleobases. The conformation of the nucleosides is studied and the antiviral activity is evaluated.
authors.affiliation: Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Seela
authors.forename: W
authors.initials: W
authors.lastname: Lin
authors.forename: Z
authors.initials: Z
authors.lastname: Kazimierczuk
authors.forename: H
authors.initials: H
authors.lastname: Rosemeyer
authors.forename: V
authors.initials: V
authors.lastname: Glaron
authors.forename: X
authors.initials: X
authors.lastname: Peng
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.forename: X
authors.initials: X
authors.lastname: Ming
authors.forename: M
authors.initials: M
authors.lastname: Andrzejewska
authors.forename: A
authors.initials: A
authors.lastname: Gorska
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Eickmeier
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D001482:Base Composition; D001562:Benzimidazoles / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018360:Crystallography, X-Ray; D015195:Drug Design; D006031:Glycosylation; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D011687:Purines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D014227:Triazines / Q000737:chemistry; D014965:X-Rays
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D009705:Nucleosides; D011687:Purines; D011743:Pyrimidines; D014227:Triazines; C015008:triazolopyrimidinone; C031000:benzimidazole