Preparation and characterization of bolaform surfactant vesicles.
Vesicular formulations (liposomes and niosomes) play an increasingly important role since they can be used as drug delivery and targeting systems. We described the formation of two niosomal systems based on synthetic bolaform surfactants (4,7,10,13-pentaoxa-16-aza-cyclooctadecane)-hexadecanedioc acid diamide (BD-16) and alpha,omega-(4,7,10,13-pentaoxa-16-aza-cyclooctadecane)-hexadecane (BC-16). Systems containing BD-16 or BC-16 and different amount of cholesterol (CH) were prepared by aqueous dispersion of films, followed by examination of methylene blue (MB) entrapment, particle size and morphology. Indeed, we also studied the hydration in the distilled water and physiological solution, in order to investigate the complexing ability on vesicle formation. The results obtained in this study show a high encapsulation capacity and this ability and the size depends on cholesterol content.
Muzzalupo
Rita
R
Department of Pharmaceutical Science, Calabria University, Ponte P. Bucci, Ed. Polifunzionale, 87030 Rende, Italy. rita.muzzalupo@unical.it
Trombino
Sonia
S
Iemma
Francesca
F
Puoci
Francesco
F
La Mesa
Camillo
C
Picci
Nevio
N
D002784:Cholesterol / Q000737:chemistry*; D043844:Crown Ethers / Q000737:chemistry*; D016503:Drug Delivery Systems; D008051:Lipid Bilayers; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry; D008567:Membranes, Artificial; D008751:Methylene Blue / Q000008:administration & dosage / Q000031:analogs & derivatives; D046529:Microscopy, Electron, Transmission; D013501:Surface-Active Agents / Q000737:chemistry*
C508065:BC-16 compound; C508064:BD-16 compound; D043844:Crown Ethers; D008051:Lipid Bilayers; D008081:Liposomes; D008567:Membranes, Artificial; D013501:Surface-Active Agents; C103428:3,7-bis(diethylamino)phenothiazin-5-ium; D002784:Cholesterol; D008751:Methylene Blue