Nocturnal oxygen desaturation as a predictive risk factor for coronary restenosis after coronary intervention.
BACKGROUND
Sleep-disordered breathing may affect coronary artery disease, so patients treated by percutaneous transluminal coronary angioplasty were studied to investigate the relationship between nocturnal oxygen desaturation (NOD) and the loss index.


RESULTS
The nocturnal oxygen desaturation index (ODI) was determined by means of a pulse oximeter in 35 patients with coronary artery disease treated by stent placement. The patients were divided into 3 groups according to ODI: <5 events/h (group N, n=6), between 5 and 14 events/h (group A, n=19), and >or=15 events/h (group B, n=10). The relationship between the ODI and loss index was examined in each group. The loss index, 0.27+/-0.23 in group N, 0.30+/-0.27 in group A, and 0.70+/-0.32 in group B, differed significantly between groups N and B (p=0.007). In all patients, the loss index showed a significant positive correlation with the ODI (R=0.585, p=0.002).


CONCLUSIONS
These findings suggest that NOD may be an important contributor to coronary restenosis in patients treated with stent placement.
Hayashi
Motonori
M
The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Fujimoto
Keisaku
K
Urushibata
Kazutoshi
K
Imamura
Hiroshi
H
Kinoshita
Osamu
O
Kubo
Keishi
K
D000368:Aged; D000800:Angioplasty, Balloon; D001785:Blood Gas Monitoring, Transcutaneous; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000628:therapy*; D023903:Coronary Restenosis / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D011237:Predictive Value of Tests; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000097:blood* / Q000209:etiology
D010100:Oxygen