Resting metabolic rate is not reduced in obese adults with Down syndrome.
Resting metabolic rate (RMR) of 22 individuals with Down syndrome was compared to that of 20 nondisabled control individuals of similar age (25.7 and 27.4 years, respectively). Using a ventilated hood system, we measured RMR in the early morning after an overnight fast. Peak aerobic capacity (VO2peak) and body composition were also determined. Resting metabolic rate was not different between groups. Adjusting RMR for body weight or body surface area did not change these findings. Using stepwise regression for the total population and each subgroup, we found that only body surface area was a significant predictor of RMR. These data show that individuals with Down syndrome do not have lower RMR than their nondisabled peers, suggesting that reduced RMR does not explain the high incidence of obesity in this population.
Fernhall
Bo
B
College of Applied Life Studies, University of Illinois at Urbana-Champaign, 1206 S. Fourth St. MC-586, Champaign, IL 61820, USA. fernhall@uiuc.edu
Figueroa
Arturo
A
Collier
Scott
S
Goulopoulou
Styliani
S
Giannopoulou
Ifigenia
I
Baynard
Tracy
T
D000293:Adolescent; D000328:Adult; D001481:Basal Metabolism / Q000502:physiology*; D004314:Down Syndrome / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000378:metabolism*