cadherin-6 message expression in the nervous system of developing zebrafish.
Cadherins are cell surface adhesion molecules that play important roles in development of a variety of tissues including the nervous system. In this study, we analyzed expression pattern of cadherin-6, a member of the type II cadherin subfamily, in the embryonic zebrafish nervous system using in situ hybridization methods. cadherin-6 message is first expressed by the neural keel, then by restricted regions in the brain and spinal cord. cadherin-6 expression in the brain transiently delineates specific brain regions. In the peripheral nervous system, cadherin-6 message is expressed by the neurogenic placodes and the dorsal root ganglia. As development proceeds, cadherin-6 expression domain and/or expression levels increased in the embryonic nervous system. Our results show that cadherin-6 expression in the zebrafish developing nervous system is both spatially and temporally regulated, implicating a role for cadherin-6 in the formation of these nervous structures.
Liu
Qin
Q
Department of Biology, University of Akron, Akron, Ohio 44325-3908, USA. qliu@uakron.edu
Liu
Bei
B
Wilson
Amy L
AL
Rostedt
Jason
J
D000818:Animals; D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics*; D002490:Central Nervous System / Q000737:chemistry / Q000378:metabolism*; D017933:Peripheral Nervous System / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics* / Q000378:metabolism
D015820:Cadherins; D012333:RNA, Messenger; C087310:K cadherin