title: Lack of correlation between results of ABO-incompatible living kidney transplantation and anti-ABO blood type antibody titers under our current immunosuppression.
abstract: In this study, we examined the impact of preoperative anti-A/B antibody titers on the results of ABO-incompatible living kidney transplantation (LKT). In all, 167 recipients underwent ABO-incompatible LKT at our institution between 1989 and 2002. These patients were subdivided into those transplanted under cyclosporine with azathioprine or mizoribine (Group 1, n=78) and those transplanted under tacrolimus or mycophenolate mofetil (Group 2, n=89). Overall patient survival at 5 and 10 years was 93.8% and 88.0%, respectively. Overall graft survival at 5 and 10 years was 76.9% and 55.9%, respectively. Graft survival in the patients with anti-A/B IgG titers over 1:128 was significantly lower in group 1, whereas no significant correlation between the anti-A/B IgG titers and graft survival was found in group 2. In conclusion, no correlation between anti-A/B antibody titers and the results of ABO-incompatible LKT was seen after tacrolimus or mycophenolate mofetil application.
authors.affiliation: Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan. shimmura@kc.twmu.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimmura
authors.forename: Kazunari
authors.initials: K
authors.lastname: Tanabe
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishida
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Tokumoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Naoshi
authors.initials: N
authors.lastname: Miyamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Setoguchi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakajima
authors.forename: Shouhei
authors.initials: S
authors.lastname: Fuchinoue
authors.forename: Satoshi
authors.initials: S
authors.lastname: Teraoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Toma
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood; D001787:Blood Group Incompatibility / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival / Q000276:immunology; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged
chemical_list: D000017:ABO Blood-Group System; D000906:Antibodies; D007074:Immunoglobulin G