title: Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.
abstract: Recent evidence suggests that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193 polycytosine [poly-C] tract) contributes to the cause of type 2 diabetes, but previous studies only just reached significance. We aimed to investigate this association. We compared patients with type 2 diabetes (n=992) with two independent control groups (n=536, n=1029) from the UK, and saw no difference in the frequency of the 16184-16193 poly-C tract. This finding was confirmed by a meta-analysis of European studies of 1455 patients and 3132 controls (odds ratio 1.16, 95% CI 0.94-1.44). Genetic variation of the 16184-16193 poly-C tract is unlikely to have a major role in the cause of type 2 diabetes.
authors.affiliation: Mitochondrial Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK. P.F.Chinnery@ncl.ac.uk
authors.forename: P F
authors.initials: PF
authors.lastname: Chinnery
authors.forename: H R
authors.initials: HR
authors.lastname: Elliott
authors.forename: S
authors.initials: S
authors.lastname: Patel
authors.forename: C
authors.initials: C
authors.lastname: Lambert
authors.forename: S M
authors.initials: SM
authors.lastname: Keers
authors.forename: S E
authors.initials: SE
authors.lastname: Durham
authors.forename: M I
authors.initials: MI
authors.lastname: McCarthy
authors.forename: G A
authors.initials: GA
authors.lastname: Hitman
authors.forename: A T
authors.initials: AT
authors.lastname: Hattersley
authors.forename: M
authors.initials: M
authors.lastname: Walker
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D015201:Meta-Analysis as Topic; D011066:Poly C / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial; D011066:Poly C