Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section.
This prospective, placebo-controlled, double-blinded, and randomized study was undertaken to compare the efficacy of granisetron, droperidol, and combinations of granisetron with droperidol or dexamethasone on postoperative nausea and vomiting in patients undergoing general anesthesia for cesarean section. Patients (n = 150) who were scheduled for cesarean section under general anesthesia were randomly assigned to one of the five groups: physiological saline 5 ml in Group A, granisetron 40 microg/kg + dexamethasone 8 mg in Group B, granisetron 40 microg/kg + droperidol 1.25 mg in Group C, droperidol 1.25 mg in Group D, and granisetron 40 microg/kg in Group E were administered intravenously after clamping of the fetal umbilical cord. Postoperative nausea and vomiting was observed for 024 h after the anesthesia. Cesarean sections were all performed under general anesthesia. Postoperative nausea and vomiting was more common in placebo group (56.7%) than the others during the 0-24 h after the anesthesia (p < 0.05). All granisetron groups were more effective than placebo and droperidol groups during the postoperative 3-24 h (p < 0.01). Although this trial lacks statistical power, granisetron alone and combinations with droperidol or dexamethasone were effective similarly. All treatment groups, except droperidol during the postoperative 3-24 h, were effective for prevention of postoperative nausea and vomiting during the postoperative 0-24 h.
Kocamanoglu
I S
IS
Department of Anesthesiology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. serhatk@omu.edu.tr
Baris
S
S
Karakaya
D
D
Sener
B
B
Tur
A
A
Cetinkaya
M
M
D000328:Adult; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D000932:Antiemetics / Q000627:therapeutic use*; D002585:Cesarean Section; D003907:Dexamethasone / Q000627:therapeutic use*; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000627:therapeutic use
D000932:Antiemetics; D003907:Dexamethasone; D004329:Droperidol; D004338:Drug Combinations; D017829:Granisetron; D012702:Serotonin Antagonists