title: Two case reports of successful prevention of overdosing in borderline patients.
abstract: Overdosing often occurs among patients with borderline personality disorder (BPD) and confronts physicians with the dilemma of whether to prescribe psychotropic agents for them or not. Prescribing psychotropic agents is often unavoidable in the real world, because psychotherapy alone is sometimes insufficient to control their labile emotions. We report two cases of BPD in which overdosing was successfully prevented by changing the dosage form from tablets to a powder and adding a bitter taste to make it difficult to swallow a large dose at one time. Prevention of overdosing by BPD patients definitely requires a comprehensive treatment approach in terms of its social, biological, psychological, and psychopathological aspects. Although no perfect method of preventing overdosing is currently available, our method provides an option when psychotropic agents are prescribed for BPD patients in clinical practice.
authors.affiliation: Department of Neuro-Psychiatry, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. mcn41320@biglobe.ne.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uchida
authors.forename: Koichiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takefumi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Akiko
authors.initials: A
authors.lastname: Goto
authors.forename: Haruo
authors.initials: H
authors.lastname: Kashima
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000188:drug therapy*; D062787:Drug Overdose / Q000517:prevention & control; D005260:Female; D006801:Humans; D011208:Powders; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D016728:Self-Injurious Behavior / Q000523:psychology
chemical_list: D011208:Powders; D011619:Psychotropic Drugs