1-Hydroxy-1-norresistomycin and resistoflavin methyl ether: new antibiotics from marine-derived streptomycetes.
Cultivation of the marine-derived streptomycete isolate B8005 delivered three known antibiotics, resistomycin (1), resistoflavin (3a) and tetracenomycin (4), and a further member of the rare resistomycin class, the weakly antibiotically active 1-hydroxy-1-norresistomycin (2). From a related marine strain B4842, 1 and resistoflavin methyl ether (3b) have been isolated. The formation of 2 is of interest from a biosynthetic point of view.
Kock
Ines
I
Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammanstrasse 2, D-37077 Göttingen, Germany.
Maskey
Rajendra P
RP
Biabani
M A Farooq
MA
Helmke
Elisabeth
E
Laatsch
Hartmut
H
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001580:Benzopyrenes / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D004987:Ethers / Q000493:pharmacokinetics; D019015:Geologic Sediments / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011721:Pyrenes / Q000493:pharmacokinetics; D013302:Streptomyces / Q000737:chemistry*
C506325:1-hydroxy-1-norresistomycin; D000900:Anti-Bacterial Agents; D001580:Benzopyrenes; D004987:Ethers; D011721:Pyrenes; C506327:resistoflavin methyl ether; C018379:resistomycin