Centaurin beta4 in cancer.
Centaurin beta4 proteins are products of the DDEF1 (development and differentiation-enhancing factor 1) locus on human chromosome 8q24.1-24.2. Recent reports have indicated that this region and its products are amplified during development of several human cancers. Centaurins are GAPs (GTPase-activating proteins) that, together with GEFs (guanine nucleotide-exchange factors), regulate cyclic activation of Arfs (ADP-ribosylation factors), members of the Ras GTPase superfamily. Centaurin beta4 proteins associate with a variety of cellular signalling components implicated in control of growth, survival and movement and may act to direct assembly and/or disassembly of molecular complexes in concert with Arf, lipid and protein phosphorylation signalling pathways.
Martin
R K
RK
Dermatological Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK.
Jackson
T R
TR
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D008055:Lipids / Q000737:chemistry; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology
C117891:ASAP1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D008055:Lipids