Corticotropin-releasing factor binding protein--a ligand trap?
The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
Jahn
Olaf
O
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Goettingen, Germany.
Radulovic
Jelena
J
Stiedl
Oliver
O
Tezval
Hossein
H
Eckart
Klaus
K
Spiess
Joachim
J
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D003072:Cognition Disorders / Q000188:drug therapy; D003346:Corticotropin-Releasing Hormone / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D018019:Receptors, Corticotropin-Releasing Hormone / Q000737:chemistry / Q000378:metabolism*; D054832:Urocortins
D002352:Carrier Proteins; D008024:Ligands; D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; C067133:corticotropin releasing factor-binding protein; D003346:Corticotropin-Releasing Hormone