title: Synthesis and evaluation of azaindole-alpha-alkyloxyphenylpropionic acid analogues as PPARalpha/gamma agonists.
abstract: A series of azaindole-alpha-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure-activity relationship was developed for PPARalpha/gamma dual agonism. One of the synthesized compound 7a was identified as a potent, selective PPARalpha/gamma dual agonist.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
authors.forename: Zhefeng
authors.initials: Z
authors.lastname: Cai
authors.forename: Jun
authors.initials: J
authors.lastname: Feng
authors.forename: Yanshen
authors.initials: Y
authors.lastname: Guo
authors.forename: Pingping
authors.initials: P
authors.lastname: Li
authors.forename: Zhufang
authors.initials: Z
authors.lastname: Shen
authors.forename: Fengming
authors.initials: F
authors.lastname: Chu
authors.forename: Zongru
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D002460:Cell Line; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D047493:PPAR alpha / Q000819:agonists*; D047495:PPAR gamma / Q000819:agonists*; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011993:Recombinant Fusion Proteins / Q000819:agonists; D013329:Structure-Activity Relationship
chemical_list: D047493:PPAR alpha; D047495:PPAR gamma; D010666:Phenylpropionates; D011993:Recombinant Fusion Proteins