Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells.
The bioassay-guided fractionation of the MeOH extract of Galla Rhois furnished two hepatoprotective compounds, an equilibrium mixture of 3-galloyl-gallic acid and 4-galloyl-gallic acid isomers (3), 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (4), and two inactive phenolic compounds, gallic acid methyl ester (1) and gallic acid (2). Compounds 3 and 4 showed significant hepatoprotective effects with EC50 values of 70.39+/-5.4 and 29.51+/-0.7 microM, respectively, against tacrine-induced cytotoxicity, and 150.9+/-6.4 and 23.81+/-0.5 microM, respectively, against nitrofurantoin-induced cytotoxicity in Hep G2 cells.
An
Ren-Bo
RB
College of Pharmacy, Wonkwang University, Korea.
Oh
Hyuncheol
H
Kim
Youn-Chul
YC
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009582:Nitrofurantoin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013619:Tacrine / Q000037:antagonists & inhibitors* / Q000633:toxicity*
D004365:Drugs, Chinese Herbal; D010636:Phenols; D010936:Plant Extracts; D013619:Tacrine; D009582:Nitrofurantoin