Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists.
A novel series of phenylamino acetamide derivatives was synthesized. These amides were shown to be potent and selective kappa opioid receptor agonists.
Chu
Guo-Hua
GH
Department of Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA. ghchu@adolor.com
Gu
Minghua
M
Cassel
Joel A
JA
Belanger
Serge
S
Stabley
Gabriel J
GJ
DeHaven
Robert N
RN
Conway-James
Nathalie
N
Koblish
Mike
M
Little
Patrick J
PJ
DeHaven-Hudkins
Diane L
DL
Dolle
Roland E
RE
D000081:Acetamides / Q000737:chemistry*; D000701:Analgesics, Opioid / Q000737:chemistry* / Q000494:pharmacology; D000814:Aniline Compounds / Q000737:chemistry*; D000818:Animals; D006801:Humans; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013329:Structure-Activity Relationship
D000081:Acetamides; D000701:Analgesics, Opioid; D000814:Aniline Compounds; D017473:Receptors, Opioid, kappa; C030686:acetamide