Remission of severe antiphospholipid syndrome associated with non-Hodgkin's B-cell lymphoma after combined treatment with rituximab and chemotherapy.
The association of lymphoid neoplasms and antiphospolipid antibodies (APA), with or without thromboembolic complications, has been reported in several cases. We describe one case of B-cell non-Hodgkinís lymphoma (NHL) in which the combination of rituximab with standard chemotherapy led to the complete remission of a severe hypercoagulable state associated with APA.
Veneri
Dino
D
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Università di Verona, Italy. dino.veneri@univr.it
Ambrosetti
Achille
A
Franchini
Massimo
M
Mosna
Federico
F
Poli
Giovanni
G
Pizzolo
Giovanni
G
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000925:Anticoagulants / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016736:Antiphospholipid Syndrome / Q000209:etiology*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology; D012008:Recurrence; D012074:Remission Induction; D000069283:Rituximab; D013156:Splenectomy; D019851:Thrombophilia / Q000188:drug therapy / Q000209:etiology*; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage; D014859:Warfarin / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000925:Anticoagulants; D000069283:Rituximab; D014750:Vincristine; D014859:Warfarin; D004317:Doxorubicin; D003520:Cyclophosphamide; D006493:Heparin; D011241:Prednisone