[Anti-CD4 autoimmunity in HIV-infected persons in Russia].
The frequency of anti-CD4 antibodies was determined in the sera or plasma derived from the patients infected with HIV-1 belonging to different genetic subgroups. The anti-CD4-antibodies in a dilution of > or = 1:1000 were found in 14% of the patients infected with the gagA/envA virus characteristic for injectable drug users in East Europe. The frequency of autoimmune antibodies among the HIV-infected patients with envB virus was substantially less (4.4%). Competitive ELISA using monoclonal antibodies to different CD4 domains demonstrated that irrespective of the viral genotype, the autoimmune epitope is located within the D4 or D3/D4 domains of CD4 receptor.
Lideman
L F
LF
Kasennova
E V
EV
Denisova
G F
GF
Stakhanova
V M
VM
Zverev
S Ia
SIa
Gibadulin
R A
RA
Bobkov
A F
AF
D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000097:blood*; D015704:CD4 Antigens / Q000276:immunology*; D016384:Consensus Sequence; D018984:Epitopes, T-Lymphocyte; D005260:Female; D015693:Gene Products, nef / Q000235:genetics; D015658:HIV Infections / Q000097:blood* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D054298:Human Immunodeficiency Virus Proteins; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D013045:Species Specificity; D015819:Substance Abuse, Intravenous / Q000097:blood; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics; D054311:nef Gene Products, Human Immunodeficiency Virus; D000086082:Viroporin Proteins
D001323:Autoantibodies; D015704:CD4 Antigens; D018984:Epitopes, T-Lymphocyte; D015693:Gene Products, nef; D054298:Human Immunodeficiency Virus Proteins; D054334:Viral Regulatory and Accessory Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins