Discovering causes and cures for cancer from gene expression analysis.
Tumorigenesis is governed by a series of complex genetic and epigenetic changes. Both mechanisms can result in either the silencing or aberrant expression of messages in a cell. Gene expression profiling techniques such as the serial analysis of gene expression (SAGE) or microarray analysis can provide global overviews of these changes, as well identify key genes and pathways involved in this process. This review outlines the current roles of these techniques in cancer research, and how they may contribute to finding not only mechanisms of this disease, but potential targets for therapy.
Weeraratna
Ashani T
AT
Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Drive, Box 21, Baltimore, MD 21224, USA. weerarat@grc.nia.nih.gov
D014408:Biomarkers, Tumor / Q000235:genetics; D002986:Clinical Trials as Topic; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D020411:Oligonucleotide Array Sequence Analysis; D010597:Pharmacogenetics; D011379:Prognosis; D014176:Protein Biosynthesis; D014158:Transcription, Genetic
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm