title: Hypoplastic left heart syndrome: from in-utero diagnosis to school age.
abstract: HLHS can be treated with successful survival outcome. Prenatal diagnosis of the anomaly is now quite common. Our understanding of the developmental aspects of HLHS during the second and third trimesters of gestation is advancing. Survivors of surgery are being closely followed and studied as they proceed forwards in time. A number of morbidities are identified. Many questions concerning the pathophysiological mechanisms of these morbidities exist. New therapies and treatments will certainly arise to meet the challenges these children face as they enter into adulthood, and as our understanding of this unique cardiovascular state progresses.
authors.affiliation: Fetal Heart Program, The Cardiac Center at The Children's Hospital of Philadelphia, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. rychik@email.chop.edu
authors.forename: Jack
authors.initials: J
authors.lastname: Rychik
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000000981:diagnostic imaging* / Q000601:surgery*; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011379:Prognosis; D015996:Survival Rate; D016216:Ultrasonography, Prenatal