Preparation of substituted pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines via a Pictet-Spengler cyclization.
[Reaction: see text]. A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.
Duncton
Matthew A J
MA
Department of Chemistry, ImClone Systems, 710 Parkside Avenue, Suite 2, Brooklyn, New York 11226, USA. mattduncton@yahoo.com
Smith
Leon M
LM
Burdzovic-Wizeman
Sabina
S
Burns
Aaron
A
Liu
Hu
H
Mao
Yunyu
Y
Wong
Wai C
WC
Kiselyov
Alexander S
AS
D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure
D001381:Azepines