Expression profiling in the aging brain: a perspective.
To evaluate molecular events associated with the aging process in animal models and human tissues, microarray analysis is performed at the regional and cellular levels to define transcriptional patterns or mosaics that may lead to better understanding of the mechanism(s) that drive senescence. In this review, we outline the experimental and analytical issues associated with high-throughput genomic analyses in aging brain and other tissues for a comprehensive evaluation of the current state of microarray analysis in aging paradigms. Ultimately, the goal of these studies is to apply functional genomics and proteomics approaches to aging research to develop new tools to assess age in cell- and tissue-specific manners in order to develop aging biomarkers for pharmacotherapeutic interventions and disease prevention.
Galvin
James E
JE
Department of Neurology, Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63108, USA. galvinj@neuro.wustl.edu
Ginsberg
Stephen D
SD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000502:physiology; D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000502:physiology*; D001927:Brain Diseases / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control; D004247:DNA / Q000235:genetics; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D008875:Middle Aged; D023421:Models, Animal; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control; D020411:Oligonucleotide Array Sequence Analysis
D015415:Biomarkers; D004247:DNA