Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level.
In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. To begin to assess whether beta-amyloid (Abeta) is associated with alpha-synuclein (AS) aggregation [secondary Lewy body (LB) formation], we used immunohistochemical techniques to compare the amygdala of 11 subjects with pathological aging and 18 with Alzheimer's disease. Overall, Abeta-40 plaque level was greater in cases with secondary AS aggregates. Abeta-42 plaque level was not associated with AS aggregation. Abeta-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation.
Lippa
Sara M
SM
Department of Neurology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Lippa
Carol F
CF
Mori
Hiroshi
H
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D000679:Amygdala / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis*; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D010446:Peptide Fragments / Q000032:analysis; D058225:Plaque, Amyloid / Q000473:pathology / Q000648:ultrastructure; D012016:Reference Values; D051844:alpha-Synuclein / Q000032:analysis*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D051844:alpha-Synuclein