Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides.
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters.
Fu
Nanyan
N
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Zhang
Qihan
Q
Duan
Lifang
L
Xu
Jiaxi
J
D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D019606:Phosphoamino Acids / Q000737:chemistry*; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000737:chemistry
D063065:Organophosphonates; D019606:Phosphoamino Acids; D010748:Phosphopeptides