Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease.
BACKGROUND
No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease.


METHODS
We genotyped a tetranucleotide repeat mapped in the 3'UTR of the LEP gene (LEP-tet) in 109 subjects with cardiovascular events and in 109 control subjects.


RESULTS
Univariate analysis and multivariate logistic regression analysis adjusted for age, gender, smoking status, history of hyperlipidemia, hypertension or diabetes showed not significant association between the genotype of the LEP-tet and cardiovascular diseases. Moreover, no differences were observed in the plasma leptin concentrations between cases and control subjects (22 +/- 19 vs 22 +/- 14 ng/ml, P = 0.52) and in relation to the LEP-tet classes or carriage of specific alleles (P = 0.76 for the association between LEP-tet classes and leptin levels in overall analysis).


CONCLUSIONS
In conclusion, our data do not support an association between the LEP-tet microsatellite polymorphism of the human LEP gene and cardiovascular diseases.
Porreca
E
E
Department of Medicine and Aging, and Aging Research Center, CeSI., GD'Annunzio University Foundation, Chieti-Pescara, Italy. eporreca@unich.it
Di Febbo
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C
Pintor
S
S
Baccante
G
G
Gatta
V
V
Moretta
V
V
Nisio
M Di
MD
Palka
C
C
Cuccurullo
F
F
Stuppia
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L
D020413:3' Untranslated Regions; D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics; D020738:Leptin / Q000097:blood / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors; D012907:Smoking
D020413:3' Untranslated Regions; D020738:Leptin