The role of circulating monocyte chemoattractant protein-1 as a marker of hepatic inflammation in patients with chronic liver disease.
We investigated the relationships between plasma monocyte chemoattractant protein-1, serum C-reactive protein, and the degree of hepatic inflammation in patients with chronic liver disease. Monocyte chemoattractant protein-1 concentration was correlated with the histological hepatic inflammation (estimated by the Knodell index) and with standard liver function tests (P<0.01). C-reactive protein was not correlated with any of the variables studied. These results underline the role of monocyte chemoattractant protein-1 in the pathogenesis of liver impairment and suggest that this chemokine may be a reliable marker of inflammation in hepatic derangements.
Marsillach
Judit
J
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, C/. Sant Joan s/n, 43201 Reus, Spain.
Bertran
Núria
N
Camps
Jordi
J
Ferré
Natàlia
N
Riu
Francesc
F
Tous
Mònica
M
Coll
Blai
B
Alonso-Villaverde
Carlos
C
Joven
Jorge
J
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D018932:Chemokine CCL2 / Q000097:blood*; D054407:Chemokine CCL4; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000032:analysis / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity
D015415:Biomarkers; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins; D002097:C-Reactive Protein