title: Alternative donor bone marrow transplant for children with Philadelphia chromosome ALL.
abstract: Children with Philadelphia chromosome positive (Ph+) acute lymphocytic leukemia (ALL) have only a 20% event-free survival when treated with chemotherapy alone. Bone marrow transplant (BMT) for patients with matched siblings has been associated with significantly better long-term survival. We asked whether children who lack a matched sibling donor would do as well if an alternative donor was utilized. Between 1987 and 2002, we transplanted 29 children and adolescents using either an unrelated donor (23) or a mismatched family member (six). The conditioning regimen included cytosine-arabinoside, cyclophosphamide and total body irradiation. Graft-versus-host disease (GVHD) prophylaxis consisted of T-cell depletion (antibody T10B9 or OKT3 and complement) with post transplant cyclosporine (CSA). All patients engrafted. Four developed grades III-IV acute GVHD. Three of 24 evaluable patients developed extensive chronic GVHD. Two patients died of relapse (7%). Two long-term survivors (>6 years) died of malignant glioblastoma multiforme. Event-free survival at 3, 5, and 10 years is 56, 51, and 46%, respectively. Five of six patients in >CR2 or relapse at the time of transplant died. Our data should encourage the use of alternative donor transplants early in the course of disease for children with Ph+ ALL.
authors.affiliation: Department of Pediatric Hematology, Oncology, Bone Marrow Transplant, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. jtalano@mcw.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Talano
authors.forename: J T
authors.initials: JT
authors.lastname: Casper
authors.forename: B M
authors.initials: BM
authors.lastname: Camitta
authors.forename: C A
authors.initials: CA
authors.lastname: Keever-Taylor
authors.forename: K J
authors.initials: KJ
authors.lastname: Murray
authors.forename: M
authors.initials: M
authors.lastname: Eapen
authors.forename: K L
authors.initials: KL
authors.lastname: Pierce
authors.forename: D A
authors.initials: DA
authors.lastname: Margolis
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D018572:Disease-Free Survival; D046148:Donor Selection / Q000379:methods; D005260:Female; D005909:Glioblastoma / Q000401:mortality; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008212:Lymphocyte Depletion / Q000379:methods / Q000401:mortality; D008297:Male; D016609:Neoplasms, Second Primary / Q000401:mortality; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D019172:Transplantation Conditioning / Q000379:methods; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods / Q000401:mortality
chemical_list: D007166:Immunosuppressive Agents; D003561:Cytarabine; D003520:Cyclophosphamide