[Lipid profile and alteration of body composition in growth hormone deficient adults].
BACKGROUND
The growth hormone deficiency (GHD) syndrome in adults and the increased associated cardiovascular risk have been extensively studied in recent years. Abnormal body composition with excess of visceral adiposity and adverse lipid profile are important features of this syndrome. Abnormal lipid profile has been described with increased levels of total cholesterol (C), LDL-cholesterol (LDL-C), triglycerides, decreased levels of HDL-cholesterol (HDL-C) and apolipoproteins abnormalities.


METHODS
Lipid profile and the amount of visceral adipose tissue were studied in 31 GHD adults compared with a control group of healthy subjects matched for age, gender and body mass index (BMI). Visceral adipose tissue was evaluated by abdominal computed tomography and anthropometric measurements--BMI (kg/m2) and waist circumference (cm). The lipid profile was studied by measurement of C, LDL-C, HDL-C, triglycerides, apolipoproteins A and B, and Lipoprotein (a).


RESULTS
The GHD adults showed increased visceral adipose tissue (156.66 +/- 72.72 vs. 113.51 +/- 32.97 cm2, p = 0.049), higher levels of triglycerides (158.58 +/- 80.29 vs. 97.17 +/- 12.37 mg/dl; p = 0.007) and lower HDL- cholesterol (45.41 +/- 13.30 vs. 55.34 +/- 14.31 mg/dl; p = 0.002). There were no differences in others aspects of lipid profile and anthropometric measurements.


CONCLUSIONS
Growth Hormone Deficient adults showed increased visceral adipose tissue, higher levels of triglycerides and lower HDL- cholesterol levels.
Lobo
Priscila M
PM
Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ. priscilobo@aol.com
Conceição
Flávia L
FL
Soares
Débora V
DV
Spina
Luciana D C
LD
Brasil
Rosane R L O
RR
Silva
Eliana M C da
EM
Vaisman
Mário
M
D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D019382:Human Growth Hormone / Q000097:blood / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013577:Syndrome; D014057:Tomography, X-Ray Computed
D008055:Lipids; D019382:Human Growth Hormone