title: Bacteriocin (mutacin) production by Streptococcus mutans genome sequence reference strain UA159: elucidation of the antimicrobial repertoire by genetic dissection.
abstract: Streptococcus mutans UA159, the genome sequence reference strain, exhibits nonlantibiotic mutacin activity. In this study, bioinformatic and mutational analyses were employed to demonstrate that the antimicrobial repertoire of strain UA159 includes mutacin IV (specified by the nlm locus) and a newly identified bacteriocin, mutacin V (encoded by SMU.1914c).
authors.affiliation: Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin, New Zealand.
authors.forename: John D F
authors.initials: JD
authors.lastname: Hale
authors.forename: Yi-Tian
authors.initials: YT
authors.lastname: Ting
authors.forename: Ralph W
authors.initials: RW
authors.lastname: Jack
authors.forename: John R
authors.initials: JR
authors.lastname: Tagg
authors.forename: Nicholas C K
authors.initials: NC
authors.lastname: Heng
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001430:Bacteriocins / Q000096:biosynthesis*; D019295:Computational Biology; D016680:Genome, Bacterial; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis; D012015:Reference Standards; D034361:Streptococcus mitis / Q000187:drug effects; D013295:Streptococcus mutans / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D019533:Streptococcus oralis / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D001430:Bacteriocins; C425769:mutacin IV