title: [Cystic fibrosis (CF) of adults--current problem of laryngologists. The role of genetic research].
abstract: BACKGROUND
  The goal of this work is to evaluate DNA in the direction of gene mutation in the patients with nasal polyps and/or recurring inflammation of the sinuses, and who tested negative for allergic basis of those ailments.
  
  
  METHODS
  50 patients aged 20-45 have been included in the research by the University Hospital and the Laryngological Outpatient Clinic SPSK in Białystok. The patients had symptoms of nasal polyps and recurring inflammation of the sinuses. The analysis of DNA samples of the blood according to the PCR method using the ABI Prism 3100 device and testing for finding mutations of cystic fibrosis--The Cystic Fibrosis Assay.
  
  
  RESULTS
  We discovered 1 mutation of delta F508 in a 40-year-old patient, with recurring inflammation of nasal sinuses (described in the case of this patient).
  
  
  CONCLUSIONS
  The DNA research method can be used for discovering atypical forms of CF in patients with recurring symptoms of the inflammation of the sinuses and nasal polyps, and who tested negative for allergic basis of those ailments. A wide routine screening in the direction of the mutation of CF may lead to an explanation the reason of the nasal polyps and inflammation of the sinuses.
authors.affiliation: Klinika Otolaryngologii AM w Białymstoku.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rózańska-Kudelska
authors.forename: Marek
authors.initials: M
authors.lastname: Rogowski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Godlewska-Zoładkowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sieśkiewicz
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Skawrońska
authors.forename: Witold
authors.initials: W
authors.lastname: Pepiński
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000235:genetics*; D004247:DNA / Q000032:analysis*; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012852:Sinusitis / Q000235:genetics*
chemical_list: D004247:DNA