title: Anti-IgE therapy in allergic asthma.
abstract: Despite the advanced and increasing understanding of the pathophysiology of asthma and other allergic diseases, current treatment remains unspecific and targets late events within the allergic cascade. Therefore, a novel and promising approach to treat allergic asthma is antagonizing IgE by anti-IgE antibodies. This review analyzes the role of IgE for the pathology of asthma, summarize the current data about action, safety and efficacy of anti-IgE therapy, and tries to give a rational approach for future indications and directions of treatment with anti-IgE antibodies.
authors.affiliation: Department of Paediatric Pneumology and Immunology, Charité, Campus Virchow, University Children's Hospital, Humboldt-University, Augustenburger Platz 1, D-13353 Berlin, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Rolinck-Werninghaus
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wahn
authors.forename: Eckard
authors.initials: E
authors.lastname: Hamelmann
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use*; D001249:Asthma / Q000628:therapy*; D005512:Food Hypersensitivity / Q000628:therapy; D006801:Humans; D007073:Immunoglobulin E / Q000737:chemistry / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy
chemical_list: D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies; D007073:Immunoglobulin E