title: Combination hepatic arterial infusion therapy is effective for ocular melanoma metastasis to the liver.
abstract: Regional treatments including chemotherapy have been applied to patients with malignant melanoma metastasis to the liver in clinical trials, but with limited efficacy. To improve efficacy, combination therapy may be beneficial. We had a case of multiple liver metastasis from right ocular malignant melanoma. The primary melanoma was surgically resected, and combination hepatic arterial infusion (HAI) therapy using dacarbazine, nimustine, vincristine (DAV), and cisplatin was applied to the metastatic focus. After HAI, marked regression of the liver metastatic focus was observed. Unfortunately, the patient passed away due to involvement of thrombotic thrombocytopenic purpura 9 months after the initial consultation, however, aggravation of the liver metastatic focus was not observed. Combination HAI therapy may have a potent therapeutic effect on malignant melanoma metastasis to the liver, and our regimen using DAV and CDDP may be beneficial to the improvement of prognosis without serious side effects.
authors.affiliation: Third Department of Internal Medicine, Wakayama Medical University, Kimiidera 811-1, Wakayama City 641-0012, Japan. hu11@wakayama-med.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ueda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hamagami
authors.forename: Hiroto
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kida
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ichinose
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D005134:Eye Neoplasms / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D015376:Nimustine / Q000008:administration & dosage; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015376:Nimustine; D014750:Vincristine; D003606:Dacarbazine; D002945:Cisplatin