[Effects of parathyroid hormone gene polymorphism on cardiovascular mortality].
It is well-known that secondary hyperparathyroidism of uremia influences not only bone and mineral metabolism but also cardiovascular complications. Here we reported the effects of the level of serum intact PTH and its gene polymorphism on cardiovascular and non-cardiovascular mortality in hemodialysis patients. We analyzed the association between clinico-molecular parameters and 3-year survival in 508 hemodialysis patients among whom 90 patients died. The multivariate Cox proportional hazards models showed that the presence of diabetes mellitus, levels of albumin and intact PTH, and BstB I genotype were indicated as independent predictors of cardiovascular mortality, whereas age and albumin level were indicated as those of non-cardiovascular mortality, suggesting that the level of intact PTH and its gene polymorphism effect cardiovascular mortality in hemodialysis patients.
Tsujimoto
Yoshihiro
Y
Inoue Hospital.
Tabata
Tsutomu
T
Inoue
Takashi
T
Tahara
Hideki
H
Shoji
Tetsuo
T
Shinohara
Kayo
K
Inaba
Masaaki
M
Nishizawa
Yoshiki
Y
D002318:Cardiovascular Diseases / Q000209:etiology / Q000401:mortality*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000009:adverse effects*; D015996:Survival Rate
D010281:Parathyroid Hormone