title: Minimally invasive surgery for live kidney donors: techniques and challenges.
abstract: Live kidney donation is assuming an increasingly prominent role in kidney transplantation programs. The traditional operative approach has been through an incision in the upper quadrant of the abdomen or in the loin, with the attendant potential postoperative complications associated with a large surgical wound. These problems may act as disincentives to prospective donors. The introduction of laparoscopic donor surgery in 1995 heralded a new era offering reduced post-operative pain and improved cosmetic result. It is hoped that these benefits may counter some disincentives and thereby increase donation rates. Three minimal-access approaches and their advantages and disadvantages are described: classical laparoscopic, hand-assisted laparoscopic, and retroperitoneoscopic surgery. Published reports indicate extensive experience with the first 2 of these approaches and less experience with the latter. All 3 approaches present technical, physiological, and anatomical challenges in the context of retrieving an organ that is fit for transplantation. For minimal-access surgery to be accepted as the procedure of choice for live kidney donors, it must be demonstrated that morbidity is not transferred from donor to recipient when these techniques are used. Some concerns about these procedures are addressed. High-level evidence in the form of randomized controlled trials is generally lacking, but experiences of surgeons and patients suggest that, with appropriate modifications, these techniques are safe for both donors and allografts and also benefit donors' recovery.
authors.affiliation: University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Brook
authors.forename: Michael L
authors.initials: ML
authors.lastname: Nicholson
mesh_terms: D002983:Clinical Competence; D003362:Cost-Benefit Analysis; D003404:Creatinine / Q000097:blood; D019317:Evidence-Based Medicine; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D007511:Ischemia / Q000209:etiology; D016030:Kidney Transplantation; D010535:Laparoscopy / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D007902:Length of Stay; D019520:Living Donors; D009017:Morbidity; D009392:Nephrectomy / Q000009:adverse effects / Q000191:economics / Q000193:education / Q000379:methods*; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects; D011187:Posture; D012187:Retroperitoneal Space; D016896:Treatment Outcome; D014513:Ureter / Q000098:blood supply
chemical_list: D003404:Creatinine