title: The serum levels of calcium, magnesium, iron and zinc in patients with recurrent vulvovaginal candidosis during attack, remission and in healthy controls.
abstract: The real cause of recurrent vulvovaginal candidosis (RVVC) is concealed and the etiopathogenesis of this disease remains to be determined. In a cohort study, concentrations of metals in 44 patients with RVVC and 30 healthy age-matched women were measured and compared. The concentrations of serum calcium (Ca), magnesium (Mg) and iron (Fe) were measured photometrically, the zinc (Zn) levels were determined using flame atomic absorption spectrometry. For statistical analysis were used the Student's t-tests (paired analysis for attack vs. remission; non-paired analysis for patient vs. control). Although all measured metals were within normal ranges the patients with RVVC had in contrast to the healthy controls significantly lower levels of serum Ca, Mg and Zn and insignificantly higher levels of Fe. These relative changes may contribute to the development of attacks in patients with RVVC.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Hradec Kralove, Czech Republic. spacekj@fnhk.cz
authors.forename: Jiri
authors.initials: J
authors.lastname: Spacek
authors.forename: Petr
authors.initials: P
authors.lastname: Jilek
authors.forename: Vladimir
authors.initials: V
authors.lastname: Buchta
authors.forename: Miroslav
authors.initials: M
authors.lastname: Forstl
authors.forename: Miloslav
authors.initials: M
authors.lastname: Hronek
authors.forename: Magdalena
authors.initials: M
authors.lastname: Holeckova
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D002181:Candidiasis, Vulvovaginal / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D008274:Magnesium / Q000097:blood; D016555:Matched-Pair Analysis; D008670:Metals / Q000097:blood*; D008875:Middle Aged; D010783:Photometry; D012008:Recurrence; D012075:Remission, Spontaneous; D013054:Spectrophotometry, Atomic; D015032:Zinc / Q000097:blood
chemical_list: D008670:Metals; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium