Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity.
OBJECTIVE
We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients.


METHODS
The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured.


RESULTS
Serum OPG levels (6.1 +/- 1.4 vs. 5.4 +/- 1.3 pmol/l, P = 0.011) and baPWV (1562 +/- 354 vs. 1399 +/- 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R(2) = 0.299).


CONCLUSIONS
In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.
Kim
S M
SM
Department of Family Medicine, Korea University College of Medicine, Seoul.
Lee
J
J
Ryu
O H
OH
Lee
K W
KW
Kim
H Y
HY
Seo
J A
JA
Kim
S G
SG
Kim
N H
NH
Baik
S H
SH
Choi
D S
DS
Choi
K M
KM
D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001916:Brachial Artery / Q000503:physiopathology; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin; D011673:Pulsatile Flow; D018160:Receptors, Cytoplasmic and Nuclear / Q000097:blood*; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D012044:Regression Analysis; D012815:Signal Processing, Computer-Assisted; D013599:Systole; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D006023:Glycoproteins; D015850:Interleukin-6; D008055:Lipids; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C506030:TNFRSF11B protein, human; D014280:Triglycerides; D002097:C-Reactive Protein