title: The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.
abstract: During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.
authors.affiliation: University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK. j.j.blow@dundee.ac.uk
authors.forename: J Julian
authors.initials: JJ
authors.lastname: Blow
authors.forename: Tomoyuki U
authors.initials: TU
authors.lastname: Tanaka
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D020090:Chromosome Segregation; D002875:Chromosomes / Q000737:chemistry / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004261:DNA Replication; D016193:G1 Phase / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D016196:S Phase / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism; D000097722:Cohesins
chemical_list: D064173:Anaphase-Promoting Complex-Cyclosome; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D018844:Cyclin-Dependent Kinases; D009687:Nuclear Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D000097722:Cohesins