SIR2 calls upon the ER.
Resveratrol induces longevity in C. elegans through the action of SIR2. Recently published work shows that resveratrol induces genes of the unfolded protein stress response of the endoplasmic reticulum. Paradoxically, these stress genes are repressed by SIR2, suggesting that resveratrol increases life span by inhibiting this SIR2 action.
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Marc
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Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA.
D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D008136:Longevity / Q000187:drug effects; D008565:Membrane Proteins / Q000235:genetics; D000077185:Resveratrol; D037761:Sirtuins / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D013267:Stilbenes; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C466092:ABU-1 protein, C elegans; C109773:ALX-1 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins; D008565:Membrane Proteins; D013267:Stilbenes; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; C507014:SIR-2.1 protein, C elegans; D037761:Sirtuins; D000077185:Resveratrol