[Clinical and pathological features of 112 cases with ocular adnexal lymphoproliferative lesions].
OBJECTIVE
To investigate the histopathological classification and clinical features of ocular adnexal lymphoproliferative lesions.


METHODS
The clinical, histomorphological and immuno-histochemical features of 112 cases of ocular adnexal lymphoproliferative lesions (116 paraffin specimens) were studied retrospectively. The lesions were classified according to the World Health Organization classification of tumors of haematopoietic and lymphoid tissues (2001).


RESULTS
This group of patients' ages averaged at 49. The mean duration between the onset of the symptoms and the time of presentation was 22 months. Sixteen patients (14.3%) had bilateral lesions. Proptosis or local orbital mass was presented in 69 cases (61.6%). Reactive lymphoid hyperplasia was diagnosed in 11 cases (9.8%) and atypical lymphoid hyperplasia in 10 cases (8.9%). The rest 91 cases (81.3%) were diagnosed as lymphoma, among which 74 cases (81.3%) were extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-EMZL).


CONCLUSIONS
MALT-EMZL is the most frequent type of ocular lymphoproliferative lesions in ocular adnexa. The ocular adnexal lymphoproliferative lesions show an indolent course clinically, tending to affect the old. Bilateral case is not uncommon.
You
Qi-sheng
QS
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing 100005, China.
Li
Bin
B
Zhou
Xiao-ge
XG
Sun
Xian-li
XL
An
Yu-zhi
YZ
Shi
Ji-tong
JT
Li
Liao-qing
LQ
Gao
Fei
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003230:Conjunctival Neoplasms / Q000473:pathology; D005142:Eyelid Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D055815:Young Adult