The significance of elevated CSF lactate.
The final diagnosis of 158 patients who had a cerebrospinal fluid (CSF) lactate concentration greater than 2 mmol/l was ascertained. The conditions included seizures, inflammatory changes, and proven metabolic disorders. For the diagnosis of congenital lactic acidoses, CSF lactate should ideally be measured in a seizure free patient after any acute illness.
Chow
S L
SL
Metabolic Unit, Great Ormond Street Hospital for Children, London, UK.
Rooney
Z J
ZJ
Cleary
M A
MA
Clayton
P T
PT
Leonard
J V
JV
D000140:Acidosis, Lactic / Q000134:cerebrospinal fluid / Q000151:congenital / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid / Q000175:diagnosis; D019344:Lactic Acid / Q000134:cerebrospinal fluid*; D008661:Metabolism, Inborn Errors / Q000134:cerebrospinal fluid / Q000175:diagnosis; D009369:Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis; D012640:Seizures / Q000134:cerebrospinal fluid
D015415:Biomarkers; D019344:Lactic Acid