NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro.
Krajewski
Marcin
M
Ozdowy
Przemyslaw
P
D'Silva
Loyola
L
Rothweiler
Ulli
U
Holak
Tad A
TA
D000595:Amino Acid Sequence; D001665:Binding Sites; D002846:Chromatography, Affinity; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004058:Diffusion; D017353:Gene Deletion; D005982:Glutathione Transferase / Q000378:metabolism; D006639:Histidine / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D009363:Neoplasm Proteins / Q000378:metabolism*; D009587:Nitrogen Isotopes / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D051736:Proto-Oncogene Proteins c-mdm2 / Q000737:chemistry / Q000378:metabolism*; D011522:Protons; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D017186:Titrimetry; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009587:Nitrogen Isotopes; D011522:Protons; D011993:Recombinant Fusion Proteins; D016159:Tumor Suppressor Protein p53; C403666:ZNF331 protein, human; D006639:Histidine; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D005982:Glutathione Transferase