title: Traumatic lung injury treated by extracorporeal membrane oxygenation (ECMO).
abstract: BACKGROUND
  Conventional mechanical ventilation is the mainstay of treatment for severe respiratory failure associated with trauma. However, when extensive lung injury is present, this technique may not be sufficient to prevent hypoxia, and furthermore, may exacerbate pulmonary damage by barotrauma. Extracorporeal membrane oxygenation (ECMO) has been used successfully in critically ill adult trauma patients and can offer an additional treatment modality. This study reports the use of ECMO in a cohort of adults referred with severe respiratory failure following trauma.
  
  
  METHODS
  Retrospective analysis over an 8-year period of all 28 adult patients referred to a single tertiary unit for ECMO support. Survival relative to Injury severity score (ISS), lung injury score (Murray grade), duration of treatment and patient age was evaluated.
  
  
  RESULTS
  Twenty of 28 patients who received ECMO with severe trauma related respiratory failure (mean PaO2/FiO2 of 62 mmHg) survived. Most patients had long bone fractures, blunt chest trauma, or combined injuries. Lung injury and injury severity scores, patient age, ECMO duration and oxygenation indices pre-ECMO (PaO2/FiO2) were similar in both the survivor and non-survivor groups.
  
  
  CONCLUSIONS
  A high proportion of trauma patients treated with ECMO for severe lung injury survived. This outcome appears to compare favourably to conventional ventilation techniques and may have a role in patients who develop acute severe respiratory distress associated with trauma.
authors.affiliation: Heartlink ECMO Centre, The Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. mailto:jamescordellsmith@hotmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Cordell-Smith
authors.forename: N
authors.initials: N
authors.lastname: Roberts
authors.forename: G J
authors.initials: GJ
authors.lastname: Peek
authors.forename: R K
authors.initials: RK
authors.lastname: Firmin
mesh_terms: D000063:Accidents, Traffic; D000293:Adolescent; D000328:Adult; D004630:Emergencies; D015199:Extracorporeal Membrane Oxygenation / Q000401:mortality; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000150:complications / Q000628:therapy; D011655:Pulmonary Embolism / Q000209:etiology / Q000401:mortality / Q000628:therapy; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality / Q000628:therapy; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D015996:Survival Rate; D013898:Thoracic Injuries / Q000150:complications / Q000401:mortality / Q000628:therapy; D016896:Treatment Outcome