title: Translocation (6;17)(q23;q11.2): a novel cytogenetic abnormality in congenital acute myeloid leukemia?
abstract: Congenital leukemia occurring within 4 weeks of birth is extremely rare and, excluding transient neonatal myeloproliferation associated with Down syndrome, makes up approximately 1% of childhood leukemias. It is usually seen as acute myeloid leukemia (AML), most frequently French-American-British (FAB) types M4 and M5. Recurrent cytogenetic abnormalities have been reported in this group, and in approximately one third of cases the MLL gene at 11q23 is involved. These patients generally have a poor prognosis. We present a case of congenital leukemia (AML FAB type M1) with an acquired translocation between chromosomes 6 and 17.
authors.affiliation: Department of Pediatric Haematology and North Trent Cytogenetics Service, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, United Kingdom.
authors.forename: Elspeth C
authors.initials: EC
authors.lastname: Ferguson
authors.forename: Polly
authors.initials: P
authors.lastname: Talley
authors.forename: Ajay
authors.initials: A
authors.lastname: Vora
mesh_terms: D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002896:Chromosomes, Human, Pair 6; D017809:Fatal Outcome; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000151:congenital / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic