title: Bioactive constituents from Chinese natural medicines. XV. Inhibitory effect on aldose reductase and structures of Saussureosides A and B from Saussurea medusa.
abstract: The 80% aqueous acetone extract from the whole plant of Saussurea medusa MAXIM. was found to inhibit rat lens aldose reductase (IC50=1.4 microg/ml). From this extract, flavonoids, lignans, and quinic acid derivatives were isolated together with two new ionone glycosides, saussureosides A and B. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence including the application of modified Mosher's method. In addition, some isolates were found to show an inhibitory effect on aldose reductase.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: Haihui
authors.initials: H
authors.lastname: Xie
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Tadato
authors.initials: T
authors.lastname: Tani
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006868:Hydrolysis; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D030441:Saussurea / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D001617:beta-Glucosidase / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D006027:Glycosides; C506637:saussureoside A; C506638:saussureoside B; D000449:Aldehyde Reductase; D001617:beta-Glucosidase