title: Cross-metathesis assisted by microwave irradiation.
abstract: Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the phosphine-free Hoveyda-Grubbs catalyst and the "second generation Grubbs' catalyst." While there have been reports that a "microwave effect" is observed in various transformations, the accelerations we observe are due to the efficient and rapid heating and increased pressure in the microwave apparatus.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development L.L.C., 1000 Route 202, P.O. Box 300, Raritan, New Jersey 08869, USA.
authors.forename: Frédéric C
authors.initials: FC
authors.lastname: Bargiggia
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006361:Heating; D008872:Microwaves; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D000475:Alkenes