title: New tandem Zn-promoted Brook rearrangement/ene-allene carbocyclization reactions.
abstract: [reaction: see text] A new tandem reaction was developed for the carbocyclization reaction of propargylic zinc reagents. First, we have shown that zinc salt promotes the Brook rearrangement into the carbanionic species followed by a stereospecific Zn-ene-allene carbocyclization reaction to lead to the corresponding cyclopentylmethylzinc derivatives. A single diastereoisomer is formed, even when a tertiary and a quaternary center are linked in the process.
authors.affiliation: The Mallat Family Laboratory of Organic Chemistry, Department of Chemistry, Institute of Catalysis Science and Technology, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel.
authors.forename: Rozalia
authors.initials: R
authors.lastname: Unger
authors.forename: Theodore
authors.initials: T
authors.lastname: Cohen
authors.forename: Ilan
authors.initials: I
authors.lastname: Marek