Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia.
BACKGROUND
Preeclampsia is a common hereditary disease with unclear aetiology and various genetic and environmental components. We wanted to determine whether genetic variability in the gene encoding plasma cell membrane glycoprotein-1 (PC-1) contributes to individual susceptibility to the development of preeclampsia.


METHODS
The case-control study involved 133 women with preeclampsia and 115 healthy controls. They were genotyped for the K121Q polymorphism in the PC-1 gene. chi(2) analysis was used to assess genotype and allele frequency differences between preeclamptic and control women.


RESULTS
The frequency of the PC-1 gene 121K allele was found to be equal in the two groups, being 90.2% among women with preeclampsia and 90.4% among controls (p = 0.937; OR = 1.024; 95% CI = 0.564-1.861). Also the genotype distribution of the PC-1 K121Q polymorphism was similar (p = 0.516) in the preeclamptic and control groups.


CONCLUSIONS
The K121Q polymorphism of the PC-1 gene is unlikely to be a major genetic factor predisposing to preeclampsia in Finnish women.
Saarela
Tanja
T
Department of Obstetrics and Gynaecology, University of Kuopio, Kuopio, Finland.
Hiltunen
Mikko
M
Helisalmi
Seppo
S
Heinonen
Seppo
S
Laakso
Markku
M
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005973:Glutamine; D006801:Humans; D008239:Lysine; D010727:Phosphoric Diester Hydrolases / Q000235:genetics*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011755:Pyrophosphatases / Q000235:genetics*
D005819:Genetic Markers; D005973:Glutamine; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases; D008239:Lysine