title: [Biphenyl ferulate from Glehnia littoralis].
abstract: OBJECTIVE
  To investigate the prolyl oligopeptidase inhibitory constituents from Glehnia littoralis.
  
  
  METHODS
  To determine the prolyl oligopeptidase inhibitory activity in vitro of ethanol extract of G. littoralis and its fractions with Yoshimoto's method, to separate the constituents of the active fractions by repeated silica gel column chromatogrphy.
  
  
  RESULTS
  Two ferulate compounds were isolated from EtOAc-soluble fractions of ethanol extract of G. littoralis, which (100 microg/ml) showed mile activity (inhibitory rate: 50%). Compound I, named glehnilate, was a new biphenyl ferulate. Compound II, identified as 2-(4'-hydroxyphenol)-glycol mono trans-ferulate, was isolated from this plant for the first time. Their structures were determined on the basis of their spectral data.
authors.affiliation: School of Pharmacy, Changchun College of Traditional Chinese Medicine, Changchun 130021.
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004791:Enzyme Inhibitors; D004952:Esters; D010636:Phenols; D010936:Plant Extracts; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases