Unusual olefin formation by PhSe-F trans-elimination.
A new approach to the synthesis of 2',3'-didehydro-2',3-dideoxynucleosides was described in excellent yield through unusual olefin formation by PhSe-F trans-elimination.
Du
Jinfa
J
Pharmasset, Inc., Tucker, Georgia 30084, USA. jdu@pharmasset.com
Shi
Junxing
J
Chun
Byoung-Kwon
BK
Hobbs
Ann
A
Hollecker
Laurent
L
Watanabe
Kyoichi A
KA
D000475:Alkenes / Q000737:chemistry*; D001671:Biochemistry / Q000379:methods; D015224:Dideoxynucleosides / Q000138:chemical synthesis / Q000737:chemistry*
D000475:Alkenes; D015224:Dideoxynucleosides