[Expression and significance of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the clinical implication and the expression of CD44v6 and MMP-9 protein in laryngeal squamous cell carcinoma (LSCC).


METHODS
Twenty-seven samples of LSCC and eight biopsies of adjacent non-cancerous tissue were detected with immunohistochemical technique (SABC method). The relationship between positive expression of CD44v6 or MMP-9 in LSCC and invasion or metastasis was analyzed.


RESULTS
Both CD44v6 and MMP-9 overexpressed in LSCC. The positive expression of CD44v6 was correlated with LSCC pathologic grade, cervical lymph node metastasis and postoperation survival rate (P < 0.05). The expression of MMP-9 was positively correlated with clinical staging and cervical lymph node metastasis (P < 0.05). There was a significant positive correlation between the expression of CD44v6 and MMP-9 (P < 0.01).


CONCLUSIONS
There is a relationship between the expression of CD44 and MMP-9. CD44v6 and MMP-9 might be served as an objective indicator for lymph nodal metastatic potency, tumor invasion and prognosis in LSCC.
Qin
Gang
G
Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China. qin-lzm@tom.com
Li
Wanrong
W
Sun
Xingwang
X
Zhu
Lin
L
Chen
Zhengnong
Z
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
C112697:CD44v6 antigen; D018960:Hyaluronan Receptors; D020780:Matrix Metalloproteinase 9