title: Direct and prolonged exposure to dogs does not influence the degree of skin prick test positivity to dog allergen.
abstract: BACKGROUND
  The relationship between pet ownership and the risk of developing allergic sensitization to pet allergens is still controversial. We assessed the possible effect of direct exposure to dog allergen on skin reactivity in dog-sensitized patients.
  
  
  METHODS
  We studied, in a case-control trial, 116 adults sensitized to dog allergens (55 with a dog at home for at least 10 years and 61 without it). The degree of response was assessed by skin prick test, performed in quadruplicate with three concentrations of allergenic extract: A (1:20 w/v), B (1:200 w/v) and C (1:2000 w/v). The mean diameter of each wheal was assessed using a visilog image analysis software.
  
  
  RESULTS
  No significant difference between the two groups in the wheal diameters induced by the three concentrations of dog allergen could be demonstrated.
  
  
  CONCLUSIONS
  The results of this study suggest that direct dog exposure in adults with respiratory allergy is not associated with greater cutaneous response to dog allergens, as compared to non exposed subjects.
authors.affiliation: Department of Chest Diseases, Division of Pneumology and Allergology, A. Cardarelli Hospital, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Liccardi
authors.forename: G
authors.initials: G
authors.lastname: D'Amato
authors.forename: G
authors.initials: G
authors.lastname: Walter Canonica
authors.forename: M
authors.initials: M
authors.lastname: Hrabina
authors.forename: A
authors.initials: A
authors.lastname: Piccolo
authors.forename: M
authors.initials: M
authors.lastname: D'Amato
authors.forename: G
authors.initials: G
authors.lastname: Passalacqua
mesh_terms: D000293:Adolescent; D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects / Q000032:analysis; D000485:Allergens / Q000032:analysis*; D000818:Animals; D016022:Case-Control Studies; D004285:Dogs; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012130:Respiratory Hypersensitivity / Q000209:etiology*; D012882:Skin Tests; D013997:Time Factors
chemical_list: D000485:Allergens