title: Regulation of alcohol intake with advancing age.
abstract: Previous surveys of alcohol use in the general population have not gathered sufficient data to allow for estimations of the blood alcohol levels (BACs) routinely achieved in survey participants. Our goal was to assess the influence of age on the estimated peak BAC achieved on typical drinking occasions in a representative sample (n=2,626) of the U.S. adult population. Variables related to the quantity and duration of alcohol consumption on typical drinking occasions were assessed by computer-assisted telephone interview. In addition, the height, weight, age, and gender of subjects were ascertained to be used in equations to predict the volume of distribution of ethanol (total body water). Prediction equations were used to estimate the probable peak BACs achieved during the typical drinking occasion. The survey identified 1,833 subjects ("current drinkers") of 18-89 years, who reported alcohol consumption within the past 12 months. Linear regression analyses performed on data from these "current drinkers" revealed that, for both men and women, there was an age-related decrease in the predicted peak BAC achieved on typical drinking occasions. The approaches used to modify the BAC with advancing age differed slightly for men and women, but both relied heavily upon a reduction in the quantity of consumption.
authors.affiliation: State University of New York at Buffalo, Research Institute on Addictions, 1021 Main Street, Buffalo, NY 14203, USA. york@ria.buffalo.edu
authors.forename: James L
authors.initials: JL
authors.lastname: York
authors.forename: John
authors.initials: J
authors.lastname: Welte
authors.forename: Judith
authors.initials: J
authors.lastname: Hirsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000428:Alcohol Drinking / Q000378:metabolism*; D000431:Ethanol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D000431:Ethanol