Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides.
Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).
Komatsu
Hironori
H
Catalysis Science Laboratory, Mitsui Chemicals, Inc., Chiba, Japan.
Araki
Tadashi
T
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017338:Cladribine / Q000138:chemical synthesis* / Q000494:pharmacology; D006031:Glycosylation; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry
D000970:Antineoplastic Agents; D009705:Nucleosides; D009711:Nucleotides; D010710:Phosphates; D017338:Cladribine; D011683:Purine-Nucleoside Phosphorylase