title: Catalytic asymmetric reductive Michael cyclization.
abstract: A highly efficient and chemo-, regio-, diastereo-, and enantioselective organocatalytic tandem conjugate reduction-Michael cyclization of enal enones has been developed. Accordingly, treating the enal enone with a Hantzsch dihydropyridine in the presence of a catalytic amount of an imidazolidinone organocatalyst provides cyclic keto aldehydes in high yields and enantiomeric excesses. The reaction works well with aliphatic and aromatic substrates in the synthesis of five- and six-membered carbacyclic derivatives.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany.
authors.forename: Jung Woon
authors.initials: JW
authors.lastname: Yang
authors.forename: Maria T
authors.initials: MT
authors.lastname: Hechavarria Fonseca
authors.forename: Benjamin
authors.initials: B
authors.lastname: List