Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly population.
Proliferation to phytohemagglutinin (PHA) and cell-mediated responses to influenza vaccine (FLU) were assessed in healthy elderly Caucasians, African Americans, Latinos and young Caucasians before and after immunization. Both PHA- and FLU-induced proliferation were reduced in elderly subgroups. FLU-induced proliferation increased post-vaccination in all elderly, except African Americans, but responses were lower than young. IL-2 and IFN-gamma levels did not change after vaccination of elderly, regardless of race. The altered response to FLU in elderly African Americans, compared to elderly Caucasians and Latinos, indicates that racial background is important when drawing conclusions about immune responses to FLU in mixed elderly populations.
Gardner
Elizabeth M
EM
Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA. eg25@drexel.edu
Gonzalez
Elizabeth W
EW
Nogusa
Shoko
S
Murasko
Donna M
DM
D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D044383:Black People; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D014611:Vaccination; D044465:White People; D001741:Black or African American
D007252:Influenza Vaccines; D007376:Interleukin-2; D007371:Interferon-gamma