Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose.
A model synthesis of a nucleoside boranophosphoramidate prodrug with (L)-tryptophan methyl ester was accomplished in a one-pot reaction via an H-phosphonate approach. This new type of compound is expected to possess the potent antiviral and anticancer advantages conferred by boranophosphates and normal nucleoside amino acid phosphoramidate.
Li
Ping
P
Department of Chemistry, Duke University, Box 90346, Durham, NC 27708-0346, USA.
Shaw
Barbara Ramsay
BR
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry; D000970:Antineoplastic Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004952:Esters / Q000737:chemistry; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D063065:Organophosphonates / Q000737:chemistry; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology
D000577:Amides; D000596:Amino Acids; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004952:Esters; D009705:Nucleosides; D063065:Organophosphonates; D010756:Phosphoric Acids; D011355:Prodrugs; C011067:phosphoramidic acid