title: Transverse elasticity and blood perfusion of sciatic nerves under in situ circular compression.
abstract: Biomechanical properties and microcirculation of peripheral nerves under circular compression are vital factors for nerve repair and for developing neural prostheses. Quasi-static circular compression experiments on six rabbit sciatic nerves were performed. The mean estimated Young's modulus of the sciatic nerves in the transverse direction was 66.9+/-8.0 kPa. The blood perfusion of the nerve started to decrease at a mean pressure of 30.5 mmHg and reached a stable lower level of 30% of pre-compression value at 102.8 mmHg. The findings may make a contribution to safer design of cuff electrodes to be used in neural prostheses.
authors.affiliation: Department of Mechanical Engineering, National Cheng Kung University, 1 Ta-Hsueh Road, Tainan 701, Taiwan. msju@mail.ncku.edu.tw
authors.forename: Ming-Shaung
authors.initials: MS
authors.lastname: Ju
authors.forename: Chou-Ching K
authors.initials: CC
authors.lastname: Lin
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Fan
authors.forename: Rung-Jian
authors.initials: RJ
authors.lastname: Chen
mesh_terms: D000818:Animals; D004548:Elasticity; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation / Q000502:physiology; D011817:Rabbits; D012039:Regional Blood Flow; D012584:Sciatic Nerve / Q000098:blood supply* / Q000502:physiology*; D013314:Stress, Mechanical