title: In vivo assessment of emphysema in mice by high resolution X-ray microtomography.
abstract: High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.
authors.affiliation: Department of Biomedical Sciences, Univeristy of Antwerp, Belgium.
authors.forename: A A
authors.initials: AA
authors.lastname: Postnov
authors.forename: K
authors.initials: K
authors.lastname: Meurrens
authors.forename: H
authors.initials: H
authors.lastname: Weiler
authors.forename: D
authors.initials: D
authors.lastname: Van Dyck
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: P
authors.initials: P
authors.lastname: Terpstra
authors.forename: N M
authors.initials: NM
authors.lastname: De Clerck
mesh_terms: D000818:Animals; D021621:Imaging, Three-Dimensional; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*