Effect of combined treatment with aspirin and dipyridamole on oxidative homeostasis in mouse serum.
Using the method of peroxidative luminol-dependent chemiluminescence we showed that combined treatment with aspirin in low dose and dipyridamole corrects imbalance in oxidative homeostasis in mouse serum. This state resulted from a sharp increase in prooxidant processes after platelet disaggregation with normal dose of aspirin or dose-dependent inhibition of free radical processes with dipyridamole.
Ivasenko
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IN
Institute of Cardiovascular Diseases, I. P. Pavlov St. Petersburg State Medical University, St. Petersburg. ivasenko@spmu.rssi.ru
Dorofeikov
V V
VV
Shlyakhto
E V
EV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects / Q000378:metabolism*; D004176:Dipyridamole / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects*; D008163:Luminescent Measurements; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D001241:Aspirin