High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand.
Recent reports have suggested influences of racial difference on the frequency of mutation of EGFR in lung cancer. We therefore sought to characterize the frequency and pattern of mutation of EGFR in lung adenocarcinoma in Thai patients. Overall, EGFR catalytic domain mutations were detected in 35/61 (57.4%). We found 29/60 (48.3%) of exon 19 deletions, 5/54 (9.3%) of exon 21 point mutations, and 1/54 (1.9%) of double-mutation of both exons. The presence of these mutations was significantly associated with non-smoking habit. In summary, we report a strikingly high prevalence of mutation of EGFR in Thai lung adenocarcinoma, which may explain the high response rate to the treatment with TKI among Asian populations.
Sriuranpong
V
V
Medical Oncology Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Ptumwan, Bangkok, Thailand. virote.s@chula.ac.th
Chantranuwat
C
C
Huapai
N
N
Chalermchai
T
T
Leungtaweeboon
K
K
Lertsanguansinchai
P
P
Voravud
N
N
Mutirangura
A
A
D000230:Adenocarcinoma / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D066246:ErbB Receptors / Q000235:genetics*; D005091:Exons; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013785:Thailand
D066246:ErbB Receptors