title: Relapsing sensorimotor neuropathy with ophthalmoplegia, antidisialosyl antibodies, and extramembranous glomerulonephritis.
abstract: A 72-year-old man presented with oculomotor dysfunction, subacute relapsing sensorimotor neuropathy, elevated erythrocyte sedimentation rate, IgM monoclonal paraprotein, cold agglutinins, and antidisialosyl IgM antibodies, features previously described by the acronym CANOMAD (chronic ataxic neuropathy with ophthalmoplegia, M protein, agglutination, and disialosyl antibodies). The patient also had extramembranous glomerulopathy associated with this syndrome. Treatment with corticosteroids improved both the neuropathy and glomerulopathy. This case suggests that the spectrum of neuropathy associated with monoclonal gammopathy may be broader than originally believed.
authors.affiliation: Department of Neurology, CHRU de Lille, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Delval
authors.forename: Tanya
authors.initials: T
authors.lastname: Stojkovic
authors.forename: Patrick
authors.initials: P
authors.lastname: Vermersch
mesh_terms: D000200:Action Potentials; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001799:Blood Sedimentation; D003450:Cryoglobulins / Q000032:analysis; D004576:Electromyography; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology; D008297:Male; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D009422:Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D015840:Oculomotor Nerve Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D009886:Ophthalmoplegia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011597:Psychomotor Performance; D012008:Recurrence; D013577:Syndrome
chemical_list: D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D003450:Cryoglobulins; D005732:Gangliosides; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein; C029443:cold agglutinins