Interspecies pharmacokinetics of xymedon.
Pharmacokinetics of immunomodulator xymedon at different modes of the drug administration was studied in humans, dogs, and rats. the main parameters of xymedon pharmacokinetics varied in different animal species. The results confirmed the efficiency and correctness of using allo-metrical method for extrapolation of pharmacokinetic data for tentative evaluation of drug parameters in humans by the results of preclinical trials on animals.
Pogorel'tsev
V I
VI
Kazan State Medical University, Kazan.
Garmonov
S Yu
SY
Polekhina
O V
OV
Reznik
V S
VS
D000042:Absorption; D000276:Adjuvants, Immunologic / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D004285:Dogs; D006801:Humans; D016014:Linear Models; D011743:Pyrimidines / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D000276:Adjuvants, Immunologic; D011743:Pyrimidines; C069705:xymedon