title: Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction.
abstract: Genetic variation may partially underlie complex personality and physiological traits--such as impulsivity, risk taking and stress responsivity--as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the study of genetic variation in these personality and physiological traits, and their influence on and interaction with addictive diseases.
authors.affiliation: Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA. kreek@rockefeller.edu
authors.forename: Mary Jeanne
authors.initials: MJ
authors.lastname: Kreek
authors.forename: David A
authors.initials: DA
authors.lastname: Nielsen
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Butelman
authors.forename: K Steven
authors.initials: KS
authors.lastname: LaForge
mesh_terms: D000818:Animals; D015897:Comorbidity; D014644:Genetic Variation; D006801:Humans; D007175:Impulsive Behavior / Q000235:genetics*; D008954:Models, Biological; D010551:Personality / Q000235:genetics; D012309:Risk-Taking; D013312:Stress, Physiological / Q000235:genetics*; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology