Gastroprotective action of glucocorticoid hormones during NSAID treatment.
In this article we present an overview of the results of our studies suggesting that endogenous glucocorticoid hormones play a role as natural defensive factors in maintaining the integrity of the gastric mucosa during treatment with non-steroidal anti-inflammatory drugs (NSAIDs). In-domethacin and aspirin at ulcerogenic doses induce a rise in corticosterone, which helps the gastric mucosa to resist the harmful actions of these ulcerogenic agents. The gastroprotective action of glucocorticoids during NSAID treatment may be mediated by multiple actions, including maintenance of glucose homeostasis, mucus production and attenuation of enhanced gastric motility and microvascular permeability. According to our findings, glucocorticoid hormones also participate in the healing processes of NSAID-induced gastric injury. It was demonstrated that there is some cooperative interaction between glucocorticoids and prostaglandins (PGs) in gastroprotection, in a way that a deficiency of one protective factor can lead to an apparently compensatory increase of the other. The gastric mucosa becomes more susceptible to injury during deficiency of both glucocorticoids and PGs.
Filaretova
L P
LP
Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, St. Petersburg 199034, Russia. filaretova@pavlov.infran.ru
Podvigina
T T
TT
Bagaeva
T R
TR
Tanaka
A
A
Takeuchi
K
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D025461:Feedback, Physiological / Q000502:physiology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D005938:Glucocorticoids / Q000378:metabolism / Q000502:physiology*; D006801:Humans
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids