Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.
The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.
Canli
T
T
Department of Psychology, Stony Brook University, Stony Brook, NY, USA.
Congdon
E
E
Gutknecht
L
L
Constable
R T
RT
Lesch
K P
KP
D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000201:enzymology*; D004252:DNA Mutational Analysis; D004644:Emotions / Q000502:physiology*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019964:Mood Disorders / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D005819:Genetic Markers; D012701:Serotonin; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase