title: [Serum levels and clinical values of soluble intercellular adhesion molecule-1 in patients with nasal polyps].
abstract: OBJECTIVE
  To assess the role of soluble intercellular adhesion molecule-1 (sICAM-1) in etiology of nasal polyps.
  
  
  METHODS
  Twenty-nine patients with nasal polyps and 20 healthy control cases were chosen. Their serum sICAM-1 was determined by a sandwich enzyme-linked immunosorbent assay (ELISA). All patients were treated by glucocorticoid, serum sICAM-1 was determined post-treatment again.
  
  
  RESULTS
  (1) Serum levels of sICAM-1 in patients with nasal polyps were higher than that of control group: (2) Serum levels of sICAM-1 in patients were reduced after glucocorticoid treatment, the decrease of sICAM-1 was more apparent in evident-effect group than in effect group; (3) There was a close correlation between the decrease of polyp-size scores and the decrease of serum sICAM-1.
  
  
  CONCLUSIONS
  The elevated expressions of sICAM-1 in patients with nasal polyps indicate its important role in eosinophil recruitment, which was considered as a representative hallmark for nasal polyps. The sICAM-1 is down-regulated by systemic and topical glucocorticoid treatment and the decrease of sICAM-1 is correlated with clinical effect. To take these lines of evidence together, anti-adhesion therapy may be effective for nasal polyps, serum sICAM-1 levels may be use to monitor the effect of steroid therapy in nasal polyps.
authors.affiliation: Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China. yuanying1973@163.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Yuan
authors.forename: Xinyong
authors.initials: X
authors.lastname: Luan
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zhang
authors.forename: Fenglei
authors.initials: F
authors.lastname: Xu
authors.forename: Dayu
authors.initials: D
authors.lastname: Liu
authors.forename: Dapeng
authors.initials: D
authors.lastname: Lei
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000097:blood* / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D018799:Intercellular Adhesion Molecule-1