title: Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence.
abstract: HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TITAGGG)4 human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, University of Naples, Faculty of Pharmacy, via Domenico Montesano 49, Napoli 80131, Italy. borbone@unina.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Borbone
authors.forename: Giuliana
authors.initials: G
authors.lastname: D'Isa
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
authors.forename: Michela
authors.initials: M
authors.lastname: Varra
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
mesh_terms: D000171:Acrolein / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides / Q000737:chemistry*; D012091:Repetitive Sequences, Nucleic Acid; D021241:Spectrometry, Mass, Electrospray Ionization; D016615:Telomere / Q000648:ultrastructure*
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D000171:Acrolein; D004247:DNA