title: [Changes in spirometric parameters and arterial oxygen saturation during a mountain ascent to over 3000 meters].
abstract: OBJECTIVE
  To ascertain whether climbing a mountain over 3000 meters high produces any alterations in ventilation, whether such alterations are modified by acclimatization, and whether they correlate with changes in arterial oxygen saturation (SaO2) or the development of acute mountain sickness (AMS).
  
  
  METHODS
  The following parameters were measured in 8 unacclimatized mountaineers who climbed Aneto (3404 m) and spent 3 days at the summit: forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), airway response to inhaled terbutaline, SaO2, and the symptoms of AMS.
  
  
  RESULTS
  At the summit, mean (SD) FEV1 declined by 12.3% (5.7%) and mean FVC by 7.6% (6.7%) while the ratio of FEV1 to FVC remained normal. The means for both parameters were higher on the following day. No airway response to bronchodilator treatment was observed. The restriction disappeared entirely on descent. At the peak, SaO2 increased progressively as the climbers became acclimatized. During the ascent, FEV1 correlated with SaO2 (r=0.79). One participant who suffered from AMS had a ratio of FEV1 to FVC less than 70% and the worst SaO2 during the 3 days on the summit. Obstruction preceded the AMS symptoms, did not respond to bronchodilator treatment, and disappeared when the climber descended.
  
  
  CONCLUSIONS
  The mountaineers who climbed over 3000 meters presented restriction that correlated with hypoxemia. This restriction did not respond to bronchodilator treatment, improved with acclimatization, and disappeared on descent. One person with AMS presented obstruction that did not respond to terbutaline and disappeared on descent.
authors.affiliation: Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain. compte_lui@gva.es
authors.forename: L
authors.initials: L
authors.lastname: Compte-Torrero
authors.forename: J
authors.initials: J
authors.lastname: Botella de Maglia
authors.forename: A
authors.initials: A
authors.lastname: de Diego-Damiá
authors.forename: L
authors.initials: L
authors.lastname: Gómez-Pérez
authors.forename: P
authors.initials: P
authors.lastname: Ramírez-Galleymore
authors.forename: M
authors.initials: M
authors.lastname: Perpiñá-Tordera
mesh_terms: D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000209:etiology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009051:Mountaineering / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D013147:Spirometry; D014797:Vital Capacity
chemical_list: D010100:Oxygen