title: [Adherence to treatment in osteoporosis influence on efficiency].
abstract: Low adherence to therapies has been repeatedly described as a major determinant of poor clinical outcomes in chronic disorders. Bisphosphonates, the most widely prescribed drugs in this field, have been linked to a 12-month persistence lower than 40%. The situation is improved when using the weekly formulation compared to the daily intake of the drug. Low compliance results in lesser increase in bone mineral density and decreased anti-fracture efficacy. New medications, currently developed for the management of osteoporosis, will be user-friendly, allowing to an improvement of compliance and persistence.
authors.affiliation: Unité d'exploration du métabolisme de l'os et du cartilage CHU Centre Ville 45, Quai Godefroid Kurth 4020 Liège, Belgique. jyreginster@ulg.ac.be
authors.forename: J Y
authors.initials: JY
authors.lastname: Reginster
authors.forename: V
authors.initials: V
authors.lastname: Rabenda
mesh_terms: D002626:Chemistry, Pharmaceutical; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D010349:Patient Compliance
chemical_list: D004164:Diphosphonates