title: Hemolymphangiomatosis of the spleen: imaging features.
abstract: Hemolymphangiomatosis is an extremely rare entity that has never been described in the diffuse form. Its main pathologic feature is proliferation of lymphatic and vascular cells inducing interstitial and hematic lakes and then splenomegaly. We report a complete imaging study, including magnetic resonance (MR) imaging, after administration of a superparamagnetic contrast agent. Ultrasonography (US), basal MR imaging, and late computed tomography (CT) contrastographic features are quite similar to those of other diffuse benign vascular neoplasms, without real hemangioma-like enhancement during the vascular phase. Its late contrastographic pattern could be considered specific if CT and iron oxide-enhanced MR imaging are applied as complementary diagnostic tools, however.
authors.affiliation: Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Università degli Studi di Firenze, Azienda Ospedaliero--Universitaria di Careggi, Florence, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Santoro
authors.forename: Valeria
authors.initials: V
authors.lastname: Santini
authors.forename: Simonetta Di
authors.initials: SD
authors.lastname: Lollo
authors.forename: Andrea
authors.initials: A
authors.lastname: Valeri
authors.forename: Stefano
authors.initials: S
authors.lastname: Colagrande
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007472:Iohexol / Q000031:analogs & derivatives; D007501:Iron; D018192:Lymphangioleiomyomatosis / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles; D010087:Oxides; D035583:Rare Diseases; D013154:Spleen / Q000000981:diagnostic imaging* / Q000473:pathology*; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013163:Splenomegaly / Q000209:etiology; D013997:Time Factors; D036542:Tomography, Spiral Computed / Q000379:methods; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D007472:Iohexol; C038192:iopromide; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide