title: Relationship between upper airway obstruction and gastroesophageal reflux in a dog model.
abstract: The association between gastroesophageal reflux (GER) and upper airway obstruction in children is recognized but not well understood. Our objective was to determine if the creation of a model of upper airway obstruction in dogs would cause GER and to determine if the GER is related to intrathoracic pressure changes. Five dogs underwent evaluation with esophageal manometry and pH probe at baseline and 1 week after creation of an upper airway obstruction. Airway obstruction was created by placement of a fenestrated cuffed tracheostomy tube, which was then capped and the cuff was inflated, requiring the animals to breathe via the fenestrations. The negative inspiratory pressure (Pes) (+/- SD) increased from 11.8 +/- 4.8 cm H(2)O at baseline to 17.6 +/- 4.9 cm H(2)O 1 week after creation of an airway obstruction (p = .029). None of the dogs had GER at baseline with a reflux index (RI) value of 0.0; however, 1 week after creation of airway obstruction, three out of five dogs had GER, with a mean RI value of 21.2 +/- 21.2. There was a significant (p = .023) correlation (r = .928) of the changes in Pes and RI values following airway obstruction. Upper airway obstruction (UAO) does cause GER in this canine model. Severity of GER is significantly correlated with Pes changes.
authors.affiliation: Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, USA.
authors.forename: Richard Paul
authors.initials: RP
authors.lastname: Boesch
authors.forename: Prashant
authors.initials: P
authors.lastname: Shah
authors.forename: Mikhail
authors.initials: M
authors.lastname: Vaynblat
authors.forename: Michael
authors.initials: M
authors.lastname: Marcus
authors.forename: Murali
authors.initials: M
authors.lastname: Pagala
authors.forename: Shivinder
authors.initials: S
authors.lastname: Narwal
authors.forename: Mikhail
authors.initials: M
authors.lastname: Kazachkov
mesh_terms: D000402:Airway Obstruction / Q000150:complications*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration