title: Serum total acid phosphatase for monitoring the clinical course of giant cell tumors of bone--26 patients with 5 local recurrences.
abstract: BACKGROUND
  Giant cell tumor of bone (GCT) is a bone-destroying tumor that sometimes recurs locally after treatment. A recent study showed increased levels of serum total acid phosphatase (TACP).
  
  
  METHODS
  We assessed TACP in the serum of 26 patients with primary GCT, and in 5 of them who developed a local recurrence.
  
  
  RESULTS
  We found a correlation between TACP level in serum and tumor size. TACP levels that were elevated preoperatively in patients with GCT became normalized after surgery, but increased in 3 of the 5 patients with local recurrence.
  
  
  CONCLUSIONS
  TACP could be used as a tumor marker for monitoring response to treatment of GCT.
authors.affiliation: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Akahane
authors.forename: Ken'ichi
authors.initials: K
authors.lastname: Isobe
authors.forename: Tominaga
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000201:enzymology* / Q000601:surgery; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000097:blood / Q000201:enzymology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000201:enzymology*
chemical_list: D014408:Biomarkers, Tumor; D000135:Acid Phosphatase