Relative stability of quadruplexes containing different number of G-tetrads.
The aim of this work is to compare the physicochemical properties of three oligonucleotidic sequences, d(TGGGT), d(TGGGGT) and d(TGGGGGT), which assemble to form quadruplex structures with the same molecularity, but containing three, four, and five G-quartets, respectively. The addition of one or two G-tetrads greatly increases both the enthalpy and Tm values of the quadruplex dissociation.
Petraccone
Luigi
L
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano (SA), Italy.
Erra
Eva
E
Duro
Ida
I
Esposito
Veronica
V
Randazzo
Antonio
A
Mayol
Luciano
L
Mattia
Carlo Andrea
CA
Barone
Guido
G
Giancola
Concetta
C
D055592:Biophysical Phenomena; D001703:Biophysics; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006358:Hot Temperature; D008967:Molecular Biology / Q000379:methods*; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D004247:DNA