title: Comparison of cardiac troponin I levels in serum and sodium-citrate plasma using the ACCESS 2 immunoassay.
abstract: The aim of this study was to determine if sodium-citrate plasma is a suitable substitute for serum for cardiac troponin I (cTnI) measurement using the Beckman ACCESS 2 immunoassay. Linear regression analysis of cTnI levels in paired serum and sodium-citrate plasma samples from 80 patients provided a y-intercept of -0.0193 and a slope of 1.044. The correlation was good [r=0.995; 95% confidence interval 1.017 to 1.068, p <0.0001]. The paired results were not significantly different by Student's t-test. Serum and sodium-citrate plasma appear to be interchangeable as samples for cTnI measurement using the ACCESS 2 assay. Furthermore, the use of plasma reduces the turnaround time and may avoid false positive cTnI results due to residual fibrin.
authors.affiliation: Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Yu-Sin
authors.initials: YS
authors.lastname: Wang
authors.forename: Chen-Fen
authors.initials: CF
authors.lastname: Feng
authors.forename: Tze-Kiong
authors.initials: TK
authors.lastname: Er
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Tsai
authors.forename: Chian-Yu
authors.initials: CY
authors.lastname: Chen
authors.forename: Shun-Jen
authors.initials: SJ
authors.lastname: Chang
authors.forename: Bai-Hsiun
authors.initials: BH
authors.lastname: Chen
mesh_terms: D005189:False Positive Reactions; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D010949:Plasma / Q000737:chemistry*; D015203:Reproducibility of Results; D044967:Serum / Q000737:chemistry*; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I