In vivo assessment of emphysema in mice by high resolution X-ray microtomography.
High resolution X-ray microtomography (micro-CT) was used for the detection of emphysema in live mice. Emphysema was induced in C57BL/6 J mice by intratracheal instillation of different amounts of porcine pancreatic elastase. This emphysema could be clearly detected by micro-CT seven weeks post-treatment: analysis of the whole data set of virtual cross-sections showed the presence of a dose-dependent level of emphysema.
Postnov
A A
AA
Department of Biomedical Sciences, Univeristy of Antwerp, Belgium.
Meurrens
K
K
Weiler
H
H
Van Dyck
D
D
Xu
H
H
Terpstra
P
P
De Clerck
N M
NM
D000818:Animals; D021621:Imaging, Three-Dimensional; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*