title: Preparation of substituted pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines via a Pictet-Spengler cyclization.
abstract: [Reaction: see text]. A synthesis of the title compounds, which have found use as inhibitors of certain receptor tyrosine kinases, was achieved using a Pictet-Spengler cyclization as a key step.
authors.affiliation: Department of Chemistry, ImClone Systems, 710 Parkside Avenue, Suite 2, Brooklyn, New York 11226, USA. mattduncton@yahoo.com
authors.forename: Matthew A J
authors.initials: MA
authors.lastname: Duncton
authors.forename: Leon M
authors.initials: LM
authors.lastname: Smith
authors.forename: Sabina
authors.initials: S
authors.lastname: Burdzovic-Wizeman
authors.forename: Aaron
authors.initials: A
authors.lastname: Burns
authors.forename: Hu
authors.initials: H
authors.lastname: Liu
authors.forename: Yunyu
authors.initials: Y
authors.lastname: Mao
authors.forename: Wai C
authors.initials: WC
authors.lastname: Wong
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Kiselyov
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure
chemical_list: D001381:Azepines