title: Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0.
abstract: Preparation and evaluation of a number of stationary phases for improved chromatographic purification of pneumocandin B0, a key intermediate in the synthesis of the antifungal agent, Cancidas, has led to the identification of several materials with potential for improved performance.
authors.affiliation: Merck Research Laboratories, Merck & Co. Inc., Rahway, NJ 07065, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch
authors.forename: Jimmy O
authors.initials: JO
authors.lastname: DaSilva
authors.forename: Joseph
authors.initials: J
authors.lastname: Nti-Gyabaah
authors.forename: Firoz
authors.initials: F
authors.lastname: Antia
authors.forename: Kent
authors.initials: K
authors.lastname: Goklen
authors.forename: Russell
authors.initials: R
authors.lastname: Boyd
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D054714:Echinocandins; D010456:Peptides, Cyclic / Q000302:isolation & purification*; D012822:Silicon Dioxide
chemical_list: D054714:Echinocandins; D010456:Peptides, Cyclic; C079465:pneumocandin B(0); D012822:Silicon Dioxide