title: A cautionary note on the use of the 31P NMR spectroscopy in stereochemical correlation analysis.
abstract: Stereoselectivity in condensation of protected ribonucleoside 3'-H-phosphonates with hydroxylic components was investigated using 31P NMR spectroscopy. The correlation between absolute configuration at the phosphorus center and the chemical shifts of the produced H-phosphonate diesters and the corresponding phosphorothioates, was studied.
authors.affiliation: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14 61-704 Poznań, Poland. msob@ibch.poznan.pl
authors.forename: Michal
authors.initials: M
authors.lastname: Sobkowski
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Jankowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Stawinski
authors.forename: Adam
authors.initials: A
authors.lastname: Kraszewski
mesh_terms: D000431:Ethanol / Q000737:chemistry; D006151:Guanosine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry; D010758:Phosphorus; D010759:Phosphorus Isotopes / Q000737:chemistry; D011522:Protons; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D009841:Oligonucleotides; D063065:Organophosphonates; D010759:Phosphorus Isotopes; D011522:Protons; D012997:Solvents; D006151:Guanosine; D010758:Phosphorus; D000431:Ethanol