title: Evaluation of antidiarrheal potential of trichodesma indicum root extract in rats.
abstract: Trichodesma indicum is found as a weed throughout the greater part of India. The decoction of the root is used for diarrhea, dysentery, and fever in Indian traditional medicine. However, the traditional claims need to be validated by suitable experimental animal models. Therefore, this study was undertaken to evaluate its antidiarrheal potential in several animal models. The extract significantly inhibited the castor oil-induced diarrhea and decreased propulsion of charcoal meal through the gastrointestinal tract; it also reduced the castor oil-induced small intestinal fluid accumulation (enteropooling). The ethanol extract of T. indicum root has significant antidiarrheal activity and substantiates the use of this herbal remedy as a nonspecific treatment for diarrhea in folk medicine.
authors.affiliation: Pharmacognosy and Phytochemistry Division, Faculty of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar, Haryana, India.
authors.forename: J B
authors.initials: JB
authors.lastname: Perianayagam
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: K K
authors.initials: KK
authors.lastname: Pillai
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000930:Antidiarrheals / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001834:Body Water / Q000187:drug effects; D028082:Boraginaceae / Q000737:chemistry*; D002368:Castor Oil / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D003672:Defecation / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D000431:Ethanol / Q000737:chemistry; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D007194:India; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013535:Suspensions / Q000008:administration & dosage; D023382:Toxicity Tests, Acute / Q000379:methods
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D013535:Suspensions; D000431:Ethanol; D002368:Castor Oil