title: Comparison of the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.
abstract: OBJECTIVE
  To compare the effects of two antidepressants on exercise performance of the female patients with fibromyalgia.
  
  
  METHODS
  Fifteen patients with fibromyalgia participated in this randomized, double-blind crossover study composed of two trials separated by a 2-week washout phase. The pharmacy randomly assigned patients to two groups: (a) placebo (glucose) in the morning and 25 mg amitriptyline at bedtime or (b) 20 mg fluoxetine in the morning and placebo at bedtime. The VO(2max) and Wingate anaerobic test were evaluated. Within 24 h after 15-day medication, the tests were repeated.
  
  
  RESULTS
  Peak power and fatigue index increased, and VO(2max) and VT did not change with both fluoxetine and amitriptyline. Mean power significantly increased after fluoxetine but not after amitriptyline.
  
  
  CONCLUSIONS
  Both amitriptyline administration and fluoxetine administration in patients with fibromyalgia have beneficial effects on anaerobic performance. These effects may be important in life quality of the female patients with fibromyalgia.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Selcuk University, Meram, Konya, Turkey. ozerbil@yahoo.com
authors.forename: Onder
authors.initials: O
authors.lastname: Ozerbil
authors.forename: Nilsel
authors.initials: N
authors.lastname: Okudan
authors.forename: Hakki
authors.initials: H
authors.lastname: Gökbel
authors.forename: Funda
authors.initials: F
authors.lastname: Levendoğlu
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test / Q000187:drug effects*; D005221:Fatigue / Q000517:prevention & control; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy*; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D000639:Amitriptyline