[Antibacterial spectrum of antibacterial peptides from Musca domestica larvae and synergic interaction between the peptides and antibiotics].
In vitro antibacterial activities of three antibacterial peptides, alone and in combination with the antibiotics were measured by MIC and antibacterial spectrum. Synergy was observed when the peptides were combined with penicillin, streptomycin by FIC. The results show that antibacterial peptides have stronger inhibition of pathogenic bacterium, and antibacterial spectrum are very different. The interaction in antibacterial peptides, antibiotics and bacterium is extraordinary complex, except synergic action, there are antagonism and indifference.
Gong
Xia
X
Department of Food Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, China. gongxia11@tom.com
Le
Guo-Wei
GW
Li
Yun-Fei
YF
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006793:Houseflies / Q000737:chemistry*; D019476:Insect Proteins / Q000494:pharmacology*; D007814:Larva / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D019476:Insect Proteins; D010455:Peptides