title: The essential role of phosphoinositide 3-kinases (PI3Ks) in regulating pro-inflammatory responses and the progression of cancer.
abstract: Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.
authors.affiliation: School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China. kchen@ncifcrf.gov
authors.forename: Keqiang
authors.initials: K
authors.lastname: Chen
authors.forename: Pablo
authors.initials: P
authors.lastname: Iribarren
authors.forename: Wanghua
authors.initials: W
authors.lastname: Gong
authors.forename: Ji-Ming
authors.initials: JM
authors.lastname: Wang
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D017382:Reactive Oxygen Species; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt