Control of mRNA stability in eukaryotes.
mRNA turnover plays a key role in the control of gene expression. Recent work has shown that proteins involved in mRNA turnover are located in multicomponent complexes which are tightly regulated. The control of mRNA stability is also intimately linked with translational processes. This article reviews the pathways and enzymes that control mRNA turnover in eukaryotic cells and discusses their mechanisms of control.
Newbury
S F
SF
Institute of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. s.f.newbury@ncl.ac.uk
D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000502:physiology*; D005095:Exoribonucleases / Q000378:metabolism; D005786:Gene Expression Regulation; D014176:Protein Biosynthesis; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D005095:Exoribonucleases; C487208:pcm protein, Drosophila