Genome rearrangements: mother knows best!
In Paramecium, developmentally programmed genome rearrangements can be altered by the presence of homologous sequences within the maternal somatic nucleus. Newly identified RNA-binding proteins appear to mediate the transfer of homologous sequence information from the maternal to the developing somatic nucleus, facilitating epigenetic regulation of this large-scale genome reorganization.
Chalker
Douglas L
DL
Biology Department, Washington University in St. Louis, Campus Box 1137, One Brookings Drive, St. Louis, Missouri 63130, USA. dchalker@biology2.wustl.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D015321:Gene Rearrangement / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D010247:Paramecium / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D012098:Reproduction / Q000235:genetics
D016601:RNA-Binding Proteins