Disorders in the lungs-placenta system under conditions of experimental gestosis in rats.
Study of the arteriovenous difference in hormone levels and hemostasis parameters in rats with experimental gestosis induced by hyper-sodium diet showed decreased production of progesterone, increased level of hydrocortisone (resultant from its increased production and additional release of the hormone by the lungs), hypercoagulation, and retarded fetal development. Involvement of the lungs into the maintenance of optimum rheological parameters of arterial blood and a relationship between the level of fetoplacental hormones and the function of pulmonary fibrinolytic filter were detected.
Myasnikova
V V
VV
Krasnodar Affiliated Branch of Southern Bureau of Russian Academy of Medical Sciences; N. V. Karsanov National Research Center of Medical Biophysics and Introduction of New Biomedical Technologies, Tbilisi.
Lysenkov
S P
SP
Galenko-Yaroshevskii
P A
PA
Barbakidze
T R
TR
Sukoyan
G V
GV
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation / Q000502:physiology; D001835:Body Weight; D005260:Female; D047109:Fetal Development / Q000502:physiology; D005340:Fibrinogen / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D008168:Lung / Q000473:pathology*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D011225:Pre-Eclampsia / Q000139:chemically induced* / Q000473:pathology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D011922:Rats, Mutant Strains; D012212:Rheology; D017673:Sodium Chloride, Dietary / Q000633:toxicity; D013997:Time Factors
D017673:Sodium Chloride, Dietary; D011374:Progesterone; D000990:Antithrombin III; D005340:Fibrinogen; D006854:Hydrocortisone