Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin.
We present two cases of infertile male patients with oligoasthenozoospermia who were receiving anti-epilepsy medication. Complete reversal of the spermatic dysfunction followed by a successful conception was achieved after discontinuation of sodium valproate, suggesting that the drug was responsible for spermatic dysfunction in these individuals.
Hayashi
Tetsuo
T
Department of Urology, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan.
Yoshida
Soichiro
S
Yoshinaga
Atushi
A
Ohno
Rena
R
Ishii
Nobuyuki
N
Yamada
Takumi
T
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000139:chemically induced* / Q000517:prevention & control; D010672:Phenytoin / Q000627:therapeutic use*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid; D010672:Phenytoin