title: Tryptophan catabolism: identification and characterization of a new degradative pathway.
abstract: A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the intermediates 2-aminomuconate and 4-oxalocrotonate. This pathway differs from the proposed mammalian pathway which converts 2-aminomuconate to 2-ketoadipate and, ultimately, glutaryl-coenzyme A.
authors.affiliation: Department of Chemistry, Muhlenberg College, Allentown, PA 18104, USA. colabroy@muhlenberg.edu
authors.forename: Keri L
authors.initials: KL
authors.lastname: Colabroy
authors.forename: Tadhg P
authors.initials: TP
authors.lastname: Begley
mesh_terms: D019342:Acetic Acid / Q000378:metabolism; D001426:Bacterial Proteins / Q000302:isolation & purification; D016956:Burkholderia cepacia / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D008660:Metabolism / Q000235:genetics* / Q000502:physiology*; D005810:Multigene Family; D019289:Pyruvic Acid / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D019289:Pyruvic Acid; D014364:Tryptophan; D019342:Acetic Acid