Hepatitis C virus infection and mixed cryoglobulinaemia vasculitis: a review of neurological complications.
Chronic liver disease caused by hepatitis C virus (HCV) infection is commonly associated with extrahepatic manifestations, mainly mixed cryoglobulinaemia. Neurological complications in HCV-infected patients occur predominantly in the peripheral nervous system. Peripheral neuropathy in HCV infection is primarily associated with mixed cryoglobulinaemia. Central nervous system (CNS) involvement is more rarely reported. In this review, peripheral and CNS involvement associated with chronic HCV infection are described. The underlying mechanisms and treatment possibilities are discussed.
Cacoub
Patrice
P
Department of Internal Medicine, Hôpital La Pitié-Salpêtrière, Paris, France. patrice.cacoub@psl.ap-hop-paris.fr
Saadoun
David
D
Limal
Nicolas
N
Léger
Jean Marc
JM
Maisonobe
Thierry
T
D001927:Brain Diseases / Q000821:virology; D003449:Cryoglobulinemia / Q000821:virology*; D015658:HIV Infections / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D001523:Mental Disorders / Q000821:virology; D009422:Nervous System Diseases / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000821:virology; D014657:Vasculitis / Q000821:virology*