Behçet's disease, myelodysplastic syndrome, trisomy 8, gastroenterological involvement--an association.
Only a limited number of cases of Behçet's disease and hematological malignancies have been reported in the literature. We report the case of a 45 year old female patient with Behçet's disease who developed myelodysplastic syndrome, refractory anemia with excess blasts in transformation subtype, with complex chromosomal abnormalities, including excess of chromosome 8, following several years of treatment with chlorambucil for Behçet's disease. As has been described in most such cases, gastrointestinal involvement was most prominent. This case is described and the occurrence of myelodysplastic syndrome in Behçet's disease reviewed.
Eder
L
L
Internal Medicine A, Carmel Medical Center, Haifa, Israel. ben@usha.org.il
Rozenbaum
M
M
Boulman
N
N
Aayubkhanov
E
E
Wolfovitz
E
E
Zisman
D
D
Rosner
I
I
D001528:Behcet Syndrome / Q000150:complications* / Q000188:drug therapy; D002699:Chlorambucil / Q000627:therapeutic use; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000235:genetics; D014314:Trisomy
D007166:Immunosuppressive Agents; D002699:Chlorambucil