title: [Study on expression and relationship between proliferating cell nuclear antigen and p53 oncoprotein in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To observe PCNA p53 gene expression and their relationship with clinicopathologic factors in primary nasopharyngeal carcinoma(NPC).
  
  
  METHODS
  PCNA, p53 proteins were assayed with immunohistochemical technique.
  
  
  RESULTS
  The expression of p53 protein was 9.5% in chronic inflammation of nasopharyngeal epithelium(CINE), which was significantly lower than it in NPCs with 76.3% (P < 0.01). In NPCs. p53 gene expression was significantly correlated with cervical lymph node metastasis of NPCs (P < 0.01), The expression of p53 in stage II, III, lV (93.3%, 80.0% and 100% respectively) were significantly higher than that in stage I (40.0%) (P < 0.01), the expression of PCNA and p53 protein was highly correlated (P < 0.01).
  
  
  CONCLUSIONS
  The expression of p53 is the useful factor in diagnosis of NPC, the overexpression of p53 is related with the stage and cervical lymph node metastasis of NPC. And PCNA PI may represent the proliferative state of NPC, all of them may play important roles in the pathogenesis of nasopharyngeal carcinoma.
authors.affiliation: Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China. cqjj74@163.com
authors.forename: Qing
authors.initials: Q
authors.lastname: Cheng
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wei
authors.forename: Xiang
authors.initials: X
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53