Neonatal screening for glucose-6-phosphate dehydrogenase deficiency.
OBJECTIVE
This study was carried out to detect the incidence of erythrocytic Glucose-6 -Phosphate dehydrogenase (G-6-PD) deficiency, to compare the incidence of hyperbilirubinemia in G-6-PD deficient neonates as compared to G-6-PD normal neonates and to asses the usefulness of neonatal screening for G-6-PD deficiency.


METHODS
In a retrospective hospital based study 2,479 male and female neonates consecutively born at Indraprastha Apollo hospital between July 1998 to June 2003 who were screened for G-6-PD levels were evaluated for the incidence of G-6-PD deficiency.


RESULTS
Incidence of G-6-PD deficiency was found to be 2.0%. Incidence in males was 283% and female was 1.05%. The incidence of hyperbilirubinemia was found to be 32% in G-6-PD deficient neonates which was significantly higher than the incidence of hyperbilirubinemia in neonates with normal G-6-PD, which was 12.3% (P< 0.001).


CONCLUSIONS
Our data suggests that neonatal screening for G-6-PD deficiency is a useful test for preventing and early treatment of complications associated with it.
Pao
Mritunjay
M
Division of Neonatology, Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, New Delhi, India.
Kulkarni
Anjali
A
Gupta
Vidya
V
Kaul
Sushma
S
Balan
Saroja
S
D000367:Age Factors; D001663:Bilirubin / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D006932:Hyperbilirubinemia / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D010789:Phototherapy; D017354:Point Mutation; D012189:Retrospective Studies; D012737:Sex Factors
D005954:Glucosephosphate Dehydrogenase; D001663:Bilirubin