title: Highly efficient synthesis of isoquinolines via nickel-catalyzed annulation of 2-iodobenzaldimines with alkynes: evidence for dual pathways of alkyne insertion.
abstract: [reaction: see text] A wide range of substituted isoquinolines were synthesized via a highly efficient nickel-catalyzed annulation of the tert-butyl imines of 2-iodobenzaldehydes and various alkynes; examination of the regiochemistry of isoquinolines synthesized indicates that there are two different alkyne insertion pathways for the catalytic reactions.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Rajendra Prasad
authors.initials: RP
authors.lastname: Korivi
authors.forename: Chien-Hong
authors.initials: CH
authors.lastname: Cheng