Probing dipeptide trans/cis stereochemistry using pH control of thiopeptide analogues, and application to the PepT1 transporter.
The stereochemistry of thiodipeptides of proline [e.g. Ala-Psi[CS-N]-Pro] can be controlled using pH, allowing the trans-preference for substrates of the peptide transporter PepT1 to be confirmed.
Bailey
Patrick D
PD
School of Chemistry, Faraday Building, The University of Manchester, Manchester, UKM60 1QD. pat.bailey@manchester.ac.uk
Boyd
C A Richard
CA
Collier
Ian D
ID
Kellett
George L
GL
Meredith
David
D
Morgan
Keith M
KM
Pettecrew
Rachel
R
Price
Richard A
RA
D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D026901:Membrane Transport Proteins; D010455:Peptides; D013438:Sulfhydryl Compounds