title: [Role of magnesium in hypertension therapy].
abstract: Magnesium is the second most abundant intracellular cation, and the important element that has numerous biological functions in the cardiovascular system. Furthermore, magnesium acts as calcium antagonist, regulates the calcium metabolism, and finally participates in blood pressure control. Although the evidence linking magnesium intake to the prevention of cardiovascular diseases was gathered, data from clinical studies about the magnesium usage in hypertension therapy have not been conclusive. The present review discusses the novel molecular and pharmacological effects of magnesium on cardiovascular systems and the implications in the clinical hypertension therapy based on the evaluating of patients' magnesium status.
authors.affiliation: First Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Uzui
authors.forename: Jong-Dae
authors.initials: JD
authors.lastname: Lee
mesh_terms: D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008274:Magnesium / Q000502:physiology / Q000627:therapeutic use*
chemical_list: D008274:Magnesium