Gene therapy for lung cancer.
Over the past three decades, the molecular biology of lung cancer has been progressively delineated. Concurrently, gene therapy techniques have been developed that allow targeting or replacement of dysfunctional genes in cancer cells, such as activated tumor-promoting oncogenes, inactivated tumor-suppressing, or apoptosis-promoting genes. This article will review the therapeutic implications of molecular changes associated with non-small cell lung cancer and the status of gene therapy.
Toloza
Eric M
EM
Department of Surgery, Duke Thoracic Oncology Program, Duke University Medical Center, Durham, NC 27710, USA. toloz001@mc.duke.edu
D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D016207:Cytokines / Q000235:genetics; D041722:Genes, Transgenic, Suicide; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*
D016207:Cytokines