Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complex infection in a pediatric patient with AIDS.
A 5-year-old girl presented with disseminated Mycobacterium avium complex infection during advanced human immunodeficiency virus infection. Interferon-gamma or interleukin-2 monotherapy showed only limited effects. Use of a combination of interferon-gamma and interferon-2 resulted in a remarkable improvement in the patient's condition, accompanied by an increase in circulating CD4+ T cells.
Sekiguchi
Yukio
Y
Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Yasui
Kozo
K
Yamazaki
Takashi
T
Agematsu
Kazunaga
K
Kobayashi
Norimoto
N
Koike
Kenichi
K
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D018791:CD4 Lymphocyte Count; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use*; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications* / Q000188:drug therapy*
D007376:Interleukin-2; D007371:Interferon-gamma