[The Dialysis Outcomes and Practice Patterns Study (DOPPS): results of the Italian cohort].
BACKGROUND
The Dialysis Outcomes and Practice Patterns Study (DOPPS) is an international prospective, longitudinal, observational study examining the relationship between dialysis unit practices and outcomes for hemodialysis (HD) patients in seven developed countries France, Germany, Italy, Spain, United Kingdom, Japan and the United States. Results of the DOPPS in Italy are the subject of this report.


METHODS
A national representative sample of 20 dialysis units (21 in Germany) was randomly selected in each of the European DOPPS countries (Euro-DOPPS). In these units, the HD in-center patients were included on a facility census, and their survival rates continuously monitored. A representative sample of incident (269 in Italy, 1553 in the Euro-DOPPS) and prevalent (600 in Italy, 3038 in the Euro-DOPPS) patients was randomly selected from the census for more detailed longitudinal investigation with regard to medical history, laboratory values and hospital admission.


RESULTS
Comparing the Italian and Euro-DOPPS cohorts we found comparable mean age for prevalent patients (61.4 vs. 59.5 yrs), but incident patients were older in Italy. Italian prevalent patients had less cardiovascular disease, more satisfactory nutritional status and more frequent use of native vascular access. These data were associated with a comparable mortality (15.7 vs. 16.3 deaths/100 patient yrs), but morbidity was lower in Italy. Kt/V levels were comparable in the two cohorts (1.32 vs. 1.37), but 35% of Italian patients showed a Kt/V below the recommended target. Moreover, hemoglobin levels were below 11 g/dL in 60% of Italian patients.


CONCLUSIONS
The DOPPS results bring to light several positive aspects and the opportunity for further possible improvements for Italian patients, but at the same time highlight some critical points that could represent a risk for dialysis quality.
Pontoriero
G
G
Divisione di Nefrologia e Dialisi, Ospedale Alessandro Manzoni, Via Dell'Eremo 9/11, 23900 Lecco, Italy. g.pontoriero@ospedale.lecco.it
Santoro
D
D
Messina
A
A
Vitiello
P
P
Tasco
A
A
Milei
M
M
Capiferri
R
R
Bellazzi
R
R
Flammini
A
A
Baroni
A
A
Morra
M
M
Cappelli
G
G
Mucaria
S
S
Boggi
R
R
Amico
M E
ME
Volzone
A
A
D'andrea
T
T
Paglionico
C
C
Antonucci
F
F
Ivaldi
R
R
Tentori
F
F
Bragg-Gresham
J
J
Pisoni
R
R
Andreucci
V E
VE
Locatelli
F
F
D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy; D007676:Kidney Failure, Chronic / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D016896:Treatment Outcome