Individual venom variability in Crotalus durissus ruruima snakes, a subspecies of Crotalus durissus from the Amazonian region.
Venoms of six specimens of Crotalus durissus ruruima snakes from the same geographical site in the Brazilian State of Roraima, were individually assayed for their main pharmacological properties. Quantitative and qualitative differences were found and the presence of crotoxin-like isoforms in these venoms was indicated. Our findings corroborate the existence of a considerable intrapopulational variability in C. d. ruruima venoms, and the importance of using a pool of venoms for antivenom production, in general, in order to assure the neutralization of the maximum possible number of toxins from a given species.
Dos-Santos
Maria Cristina
MC
Laboratório de Imunologia, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Av. Rodrigo Octávio Jordão Ramos 3.000, CEP 69077-000 Manaus, Brazil. mcsantos@ufam.edu.br
Assis
Eduardo Borgesde
EB
Moreira
Thémis Desiré
TD
Pinheiro
Janete
J
Fortes-Dias
Consuelo Latorre
CL
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001938:Brazil; D003435:Crotalid Venoms / Q000737:chemistry*; D017839:Crotalus; D003439:Crotoxin / Q000302:isolation & purification* / Q000633:toxicity*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010741:Phospholipases A / Q000378:metabolism; D020033:Protein Isoforms / Q000302:isolation & purification / Q000633:toxicity; D013045:Species Specificity
D003435:Crotalid Venoms; D020033:Protein Isoforms; D003439:Crotoxin; D010741:Phospholipases A