Mitotic entry: a matter of oscillating destruction.
Entry into mitosis is essentially driven by cyclin B1 and its associated catalytically active partner Cdk1. While cyclin B1 is kept cytoplasmic throughout interphase, nuclear accumulation occurs just prior to mitosis. This restriction is thought to be part of an oscillating mechanism to properly time mitotic entry. A novel nuclear SCF-type mammalian E3 ligase defined by the F-box containing protein NIPA (nuclear interaction partner of ALK), SCFNIPA, targets nuclear cyclin B1 in interphase while it allows for accumulation at G2/M. Thus, oscillating ubiquitination of nuclear cyclin B1 driven by the SCFNIPA complex contributes to the timing of mitotic entry in the mammalian cell cycle.
Bassermann
Florian
F
Department of Internal Medicine III, Technical University of Munich, Munich, Germany.
Peschel
Christian
C
Duyster
Justus
J
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins; D019926:Cyclin B / Q000378:metabolism; D056744:Cyclin B1; D044783:F-Box Proteins / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology; D044843:SKP Cullin F-Box Protein Ligases / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism* / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; C534699:CCNB1 protein, human; D018797:Cell Cycle Proteins; D019926:Cyclin B; D056744:Cyclin B1; D044783:F-Box Proteins; D009687:Nuclear Proteins; D025801:Ubiquitin; C477288:ZC3HC1 protein, human; D044843:SKP Cullin F-Box Protein Ligases