Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA.
In the period of 1998-2004, seven workers affected by manganese-induced Parkinsonism were diagnosed, studied and treated with CaNa2EDTA at our Occupational Health Ward. Biological markers, as well as magnetic resonance imaging and clinical examinations, were used to assess the disease trend. Those workers still employed were immediately removed from exposure. Our results seem to confirm that very good clinical, biological and neuroradiological results can be obtained by timely removal from exposure and chelating treatment, and that amelioration can persist in time. Manganism is, however, a severe condition that can also progress independent of further exposure. Therefore, chelating treatment can be a great aid in overt manganism, but particular attention must be paid to primary prevention, as this disease should now be totally preventable and definitely merits eradication.
Herrero Hernandez
Elena
E
Department of Traumatology, Orthopaedics and Occupational Health, Neurotoxicology Unit, University of Turin, Via Zuretti 29, 10126 Turin, Italy. elena.herrero@unito.it
Discalzi
Gianluigi
G
Valentini
Consuelo
C
Venturi
Fabrizio
F
Chiò
Adriano
A
Carmellino
Caterina
C
Rossi
Luigi
L
Sacchetti
Anna
A
Pira
Enrico
E
D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008345:Manganese / Q000097:blood; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D014896:Welding
D002614:Chelating Agents; D008345:Manganese; D004492:Edetic Acid