title: Highly efficient production of nootkatone, the grapefruit aroma from valencene, by biotransformation.
abstract: Nootkatone, the most important and expensive aromatic of grapefruit, decreases the somatic fat ratio, and thus its demand is increasing in the cosmetic and fiber sectors. A sesquiterpene hydrocarbon, (+)-valencene, which is cheaply obtained from Valencia orange, was biotransformed by the green algae Chlorella species and fungi such as Mucor species, Botryosphaeria dothidea, and Botryodiplodia theobromae to afford nootkatone in high yield.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Furusawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Noma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D001711:Biotransformation; D002708:Chlorella / Q000378:metabolism; D002957:Citrus / Q000737:chemistry*; D005658:Fungi / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D007700:Kinetics; D009812:Odorants; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000378:metabolism*
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C506706:valencene; C050302:nootkatone