Use of human VEGF(165) gene for therapeutic angiogenesis in coronary patients: first results.
The paper presents the first results of therapeutic angiogenesis in clinical cardiosurgery: human VEGF(165) gene transplantation to coronary patients. The use of this therapeutic method is particularly effective in patients with inoperable cardiovascular injuries, i.e. patients with the most severe condition, in whom treatment remains little effective at the modern level of cardiosurgery development.
Bokeriya
L A
LA
A. N. Bakulev Institute of Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow.
Golukhova
E Z
EZ
Eremeeva
M V
MV
Aslanidi
I P
IP
Merzlyakov
V Yu
VY
Georgiev
G P
GP
Kiselev
S L
SL
Berishvili
I I
II
Vakhromeeva
M N
MN
Serov
R A
RA
Artyukhina
T V
TV
Basarab
Yu S
YS
Polyakova
E S
ES
Lukashkin
M A
MA
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000601:surgery; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography; D004562:Electrocardiography; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply; D009204:Myocardial Revascularization; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010957:Plasmids / Q000235:genetics / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D011788:Quality of Life; D051381:Rats; D015899:Tomography, Emission-Computed, Single-Photon; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000627:therapeutic use*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2