title: Magnetic resonance spectroscopy facilitates assessment of intramyocellular lipid changes: a preliminary short-term study following biliopancreatic diversion.
abstract: BACKGROUND
  Intramyocellular content of lipid (IMCL) appears to be important in the pathogenesis of insulin resistance, and the improvement of insulin activity observed following biliopancreatic diversion (BPD) for obesity has to be related to reduction of IMCL. This study evaluates the possibility of detecting changes after BPD in IMCL by means of H1 magnetic resonance spectroscopy.
  
  
  METHODS
  The investigation was carried out in obese patients undergoing BPD prior to and at 1 month following the operation. Insulin sensitivity was assessed according to the homeostatic model of assessment (HOMA), and IMCL was determined by the spectroscopy of the tibialis anterior muscle.
  
  
  RESULTS
  At 1 month following BPD, an improvement in insulin action was observed in all subjects, and in nearly all cases the IMCL signal decreased.
  
  
  CONCLUSIONS
  The data from this study indicate that magnetic resonance spectroscopy can detect IMCL changes following BPD and is fully suitable for longitudinal studies on muscle metabolic status.
authors.affiliation: Dipartimento di Discipline Chirurgiche, Università di Genova, Genova, Italy. adami@unige.it
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Adami
authors.forename: Roberto Carlo
authors.initials: RC
authors.lastname: Parodi
authors.forename: Francesco
authors.initials: F
authors.lastname: Papadia
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marinari
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camerini
authors.forename: Roberta
authors.initials: R
authors.lastname: Corvisieri
authors.forename: Nicola
authors.initials: N
authors.lastname: Scopinaro
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000737:chemistry*; D009767:Obesity, Morbid / Q000378:metabolism* / Q000601:surgery*
chemical_list: D001786:Blood Glucose; D008055:Lipids