[Experimental study on the osseointegration of nanophase hydroxyapatite biograde-coated implants].
OBJECTIVE
To study the osseointegration of the nanophase hydroxyapatite biograde-coated implants and host bone.


METHODS
Nanophase hydroxyapatite biograde-coated implants, hydroxyapatite biograde-coated implants and noncoated Ti-6Al-4V implants were inserted into both femoral of Beagle canines the tissue response, dynamic osteogensis and SEM were studied at 4, 8 and 12 weeks.


RESULTS
The degradation of nanophase hydroxyapatite was slower than hydroxyapatite, dynamic osteogensis and the form of osteoblast were better than the control groups.


CONCLUSIONS
The biological reaction of Nanophase hydroxyapatite biograde-coated implants is better than hydroxyapatite coated implant.
Wang
Yi
Y
Department of Orthopaedic, Ruijn Hospital, Shanghai Second Medical University, Shanghai 200025, China. nealwang@hotmail.com
Tan
Yan-bin
YB
Yang
Qing-ming
QM
Deng
Lian-fu
LF
Zeng
Shao-xian
SX
D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004285:Dogs; D017886:Durapatite / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D053758:Nanoparticles; D016348:Osseointegration / Q000502:physiology; D013499:Surface Properties
D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite