[Placental functional assessment using MRI: mice today, humans tomorrow?].
Placental insufficiency, a process due to either poor placental perfusion or permeability, may lead to progressive deterioration in placental function and materno-fetal morbidity. Advances in MR contrast media pharmacokinetic studies of transit through tissues and dynamic MRI allow to characterize organs microcirculation in vivo. Placental function assessment might be achieved using analysis of dynamic contrast enhanced MRI of tracers. A murine model of placental assessment has been constructed. Herein, principles, results and limitations of such techniques are discussed as well as their potential interest and weaknesses in humans.
Salomon
L-J
LJ
Laboratoire de Recherche en Imagerie, Paris V, Faculté de Médecine Necker.
Siauve
N
N
Taillieu
F
F
Balvay
D
D
Clément
O
O
Vayssettes
C
C
Frija
G
G
Ville
Y
Y
Cuénod
C-A
CA
D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D008833:Microcirculation / Q000502:physiology; D010920:Placenta / Q000098:blood supply* / Q000502:physiology; D010927:Placental Insufficiency / Q000175:diagnosis*; D011247:Pregnancy
D003287:Contrast Media