title: Enterococcal prosthetic valve infective endocarditis: report of 45 episodes from the International Collaboration on Endocarditis-merged database.
abstract: Enterococcal prosthetic valve infective endocarditis (PVE) is an incompletely understood disease. In the present study, patients with enterococcal PVE were compared to patients with enterococcal native valve endocarditis (NVE) and other types of PVE to determine differences in basic clinical characteristics and outcomes using a large multicenter, international database of patients with definite endocarditis. Forty-five of 159 (29%) cases of definite enterococcal endocarditis were PVE. Patients with enterococcal PVE were demographically similar to patients with enterococcal NVE but had more intracardiac abscesses (20% vs. 6%; p=0.009), fewer valve vegetations (51% vs. 79%; p<0.001), and fewer cases of new valvular regurgitation (12% vs. 45%; p=0.01). Patients with either enterococcal PVE or NVE were elderly (median age, 73 vs. 69; p=0.06). Rates of in-hospital mortality, surgical intervention, heart failure, peripheral embolization, and stroke were similar in both groups. Patients with enterococcal PVE were also demographically similar to patients with other types of PVE, but mortality may be lower (14% vs. 26%; p=0.08). Notably, 93% of patients with enterococcal PVE came from European centers, as compared with only 79% of patients with enterococcal NVE (p=0.03). Thus, patients with enterococcal PVE have higher rates of myocardial abscess formation and lower rates of new regurgitation compared to patients with enterococcal NVE, but there are no differences between the groups with regard to surgical or mortality rates. In contrast, though patients with enterococcal PVE and patients with other types of PVE share similar characteristics, mortality is higher in the latter group. Importantly, the prevalence of enterococcal PVE was higher in the European centers in this study.
authors.affiliation: Duke University Medical Center and the Duke Clinical Research Institute, Box 3824, Durham, NC 27710, USA. ander077@mc.duke.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Anderson
authors.forename: L
authors.initials: L
authors.lastname: Olaison
authors.forename: J R
authors.initials: JR
authors.lastname: McDonald
authors.forename: J M
authors.initials: JM
authors.lastname: Miro
authors.forename: B
authors.initials: B
authors.lastname: Hoen
authors.forename: C
authors.initials: C
authors.lastname: Selton-Suty
authors.forename: T
authors.initials: T
authors.lastname: Doco-Lecompte
authors.forename: E
authors.initials: E
authors.lastname: Abrutyn
authors.forename: G
authors.initials: G
authors.lastname: Habib
authors.forename: S
authors.initials: S
authors.lastname: Eykyn
authors.forename: P A
authors.initials: PA
authors.lastname: Pappas
authors.forename: V G
authors.initials: VG
authors.lastname: Fowler
authors.forename: D J
authors.initials: DJ
authors.lastname: Sexton
authors.forename: M
authors.initials: M
authors.lastname: Almela
authors.forename: G R
authors.initials: GR
authors.lastname: Corey
authors.forename: C H
authors.initials: CH
authors.lastname: Cabell
mesh_terms: D000368:Aged; D016208:Databases, Factual; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D016983:Enterococcus / Q000145:classification / Q000302:isolation & purification; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006351:Heart Valves / Q000382:microbiology; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery