title: Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates.
abstract: We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Xie
authors.forename: Noman
authors.initials: N
authors.lastname: Siddiqi
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Rubin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D010640:Phenothiazines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010640:Phenothiazines