title: Distribution of strain families of Mycobacterium tuberculosis causing pulmonary and extrapulmonary disease in hospitalized children in Cape Town, South Africa.
abstract: We studied the association between strain family and extrapulmonary tuberculosis among 285 children presenting to a pediatric hospital. Extrapulmonary disease occurred in 56% of children without known human immunodeficiency virus infection, with meningitis accounting for 22% of the cases. Two strain families, LAM3/F11 and W-Beijing, predominated; but there was no overall association with extrapulmonary disease.
authors.affiliation: Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa. mnicol@curie.uct.ac.za
authors.forename: Mark P
authors.initials: MP
authors.lastname: Nicol
authors.forename: Christophe
authors.initials: C
authors.lastname: Sola
authors.forename: Bradley
authors.initials: B
authors.lastname: February
authors.forename: Nalin
authors.initials: N
authors.lastname: Rastogi
authors.forename: Lafras
authors.initials: L
authors.lastname: Steyn
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Wilkinson
mesh_terms: D002675:Child, Preschool; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics; D012189:Retrospective Studies; D013019:South Africa; D013045:Species Specificity; D014376:Tuberculosis / Q000382:microbiology*