The correlation between renal function and systolic or diastolic blood pressure in severe preeclamptic women.
OBJECTIVE
To evaluate the correlation between renal function and systolic or diastolic blood pressure in preeclamptic mothers.


METHODS
In this prospective study from August 1998 to September 2002, 28 women >or= 28 weeks gestation with severe preeclampsia were selected. Meanwhile, 56 normotensive pregnant women without proteinuria or edema served as the control group. Urine was collected for 24 hours for all subjects. The concentration of uric acid, blood urea nitrogen, creatinine, sodium, calcium, and albumin in the 24-hour urine and blood of both groups were examined. Neonatal outcome also was evaluated.


RESULTS
The serum and 24-hour urine concentration of blood urea nitrogen, creatinine, and albumin were significantly higher in severe preeclamptic women. Serum uric acid and urinary albumin/creatinine ratio was significantly higher in severe preeclamptic women compared with that in normotensive mothers and showed positive correlation with systolic or diastolic blood pressure. On the other hand, serum calcium/creatinine ratio was significantly lower in the severe preeclamptic group and negatively correlated to blood pressure. In multiple regressions, systolic or diastolic blood pressure was dependent on serum uric acid, albumin/creatinine, and calcium/creatinine ratios. Fetal birth weight was significantly lower in women with severe preeclampsia and with a lower Apgar score < 7 at 1 minute and 5 minutes and more preterm delivery compared with that in normotensive women.


CONCLUSIONS
Renal function in women with severe preeclampsia was significantly impaired and highly correlated with systolic or diastolic blood pressure.
Seow
Kok-Min
KM
Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. m0022492249@yahoo.com.tw
Tang
Ming-Hwa
MH
Chuang
Jesse
J
Wang
Yuan-Yung
YY
Chen
Da-Chung
DC
D000328:Adult; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000378:metabolism; D016009:Chi-Square Distribution; D003404:Creatinine / Q000378:metabolism; D003971:Diastole; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000652:urine*; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013599:Systole; D014527:Uric Acid / Q000378:metabolism
D012709:Serum Albumin; D014527:Uric Acid; D012964:Sodium; D003404:Creatinine; D002118:Calcium