title: [Effect of neutralizing anti-VEGF antibody on genesis of murine type II collagen-induced arthritis].
abstract: OBJECTIVE
  To understand the effect of neutralizing anti-vascular endothelial growth factor (VEGF) antibody on the genesis of murine type II collagen (CO II)-induced arthritis (CIA).
  
  
  METHODS
  mice DBA/1J (8-10 weeks) were given intradermal injection chick tape II collagen to set up the murine CIA model. The incidence of CIA and arthritis index were measured and the pathologic changes of articular tissue were observed after the injection of neutralizing anti-VEGF antibody.
  
  
  RESULTS
  The anti-VEGF antibody could notably inhibit the genesis and severity of arthritis (P<0.05) at the early stage of CIA formation; while it made no difference after CIA was completely formed.
  
  
  CONCLUSIONS
  Anti-VEGF neutralizing antibody can significantly inhibit synovial fibroblast proliferation, neovascularization and angeitis genesis, which made it a promising agent for RA treatment.
authors.affiliation: Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China. lujingtan@163.com
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Ping-ting
authors.initials: PT
authors.lastname: Yang
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Xiao
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D024043:Collagen Type II / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D013583:Synovial Membrane / Q000166:cytology; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*
chemical_list: D000906:Antibodies; D024043:Collagen Type II; D042461:Vascular Endothelial Growth Factor A