title: Formation of bone-like apatite on organic polymers treated with a silane-coupling agent and a titania solution.
abstract: Polyethylene terephthalate (PET), ethylene-vinyl alcohol copolymer (EVOH) and Nylon 6 in plate form were treated with silane-coupling agents, a titanium alkoxide-alcohol solution and a hot HCl solution to form a thin crystalline titanium oxide layer. When placed in a simulated body fluid with ion concentrations nearly equal to those of the human blood plasma, nanosized bone-like apatite formed uniformly on the surfaces of these treated polymers: within 2 days for PET and Nylon 6, and 7 days for EVOH. This indicates that such titania-modified polymers might form bone-like apatite in the living body, and bond to living bone through this apatite layer. Three-dimensional fabrics of these polymer fibers, with open spaces in various sizes, are expected to be useful as bone substitutes, as they will be integrated with the natural bone.
authors.affiliation: Institute of Science and Technology Research, Chubu University, 1200, Matsumoto-cho, Kasugai-shi, Aichi 487-8501, Japan.
authors.forename: Francisco
authors.initials: F
authors.lastname: Balas
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawashita
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kokubo
mesh_terms: D001031:Apatites / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D010949:Plasma / Q000737:chemistry; D011093:Polyethylene Terephthalates / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D011093:Polyethylene Terephthalates; D011108:Polymers; D011145:Polyvinyls; D012821:Silanes; D012996:Solutions; C009495:titanium dioxide; C009916:nylon 6; C020320:ethylene-vinyl alcohol copolymer; D002209:Caprolactam; D014025:Titanium