title: Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines.
abstract: Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
authors.affiliation: Infectious Diseases Division, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. xingz@mcmaster.ca
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xing
authors.forename: Michael
authors.initials: M
authors.lastname: Santosuosso
authors.forename: Sarah
authors.initials: S
authors.lastname: McCormick
authors.forename: Teng-Chih
authors.initials: TC
authors.lastname: Yang
authors.forename: James
authors.initials: J
authors.lastname: Millar
authors.forename: Mary
authors.initials: M
authors.lastname: Hitt
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Wan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bramson
authors.forename: H Martin
authors.initials: HM
authors.lastname: Vordermeier
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D002417:Cattle; D005822:Genetic Vectors; D051379:Mice; D011212:Poxviridae / Q000235:genetics*; D032581:Tuberculosis Vaccines / Q000627:therapeutic use; D014614:Vaccines, Synthetic / Q000627:therapeutic use; D014616:Vaccinia virus / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000494:pharmacology
chemical_list: D032581:Tuberculosis Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines