title: Antimicrobial, cytotoxic and antioxidant activity of selected basidiomycetes from Yemen.
abstract: Dichloromethane, methanol and aqueous extracts of 23 selected Basidiomycetes species fruiting bodies collected in Yemen were screened in vitro for their antibacterial activities against three Gram-positive bacteria (Staphyloccocus aureus, Bacillus subtilis, Micrococcus flavus), two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and against one yeast fungus (Candida maltosa), as well as for their cytotoxic and antioxidant activity. The highest antibacterial activity was shown by extracts from Agaricus sp. (Type 1), Coriolopsis caperata, Ganoderma colossus, Ganoderma resinaceum, Phellorinia herculea and Tulostoma obesum. Strong antioxidative effects employing the DPPH assay were exhibited by methanol extracts from Ganoderma resinaceum, Inonotus ochroporus, Phellinus rimosus and Phellorinia herculea. The results provide evidence that some of the studied fungi might be potential sources for new biologically active agents.
authors.affiliation: Department of Pharmacognosy, Aden University, Aden, Yemen.
authors.forename: M
authors.initials: M
authors.lastname: Al-Fatimi
authors.forename: M
authors.initials: M
authors.lastname: Wurster
authors.forename: H
authors.initials: H
authors.lastname: Kreisel
authors.forename: U
authors.initials: U
authors.lastname: Lindequist
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry* / Q000145:classification; D001713:Biphenyl Compounds; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D010851:Picrates / Q000737:chemistry; D012997:Solvents; D015006:Yemen
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D001713:Biphenyl Compounds; D010851:Picrates; D012997:Solvents; C004931:1,1-diphenyl-2-picrylhydrazyl