title: Polymorphisms of the BRCA2 and RAD51 genes in breast cancer.
abstract: We performed a case-control study (150 cases and 150 controls) to test the association between three polymorphisms in BRCA2 and RAD51 genes and breast cancer risk. Genotypes were determined in DNA from blood cells by PCR-RFLP. Cancer occurrence was strongly associated with the BRCA2 Met/1915Thr homozygous polymorphic variants, whereas heterozygous variant was associated with significant reduction in breast cancer risk. Gene-gene interaction between the BRCA2-Met1915Thr Thr/Thr and BRCA2-Met784Val Met/Met homozygous variants increased the risk. Therefore, the Met1915Thr polymorphism in the BRCA2 gene may be considered as an independent marker of breast cancer.
authors.affiliation: Department of Molecular Genetics, University of Lodz, Lodz, Poland, januszb@biol.uni.lodz.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sliwinski
authors.forename: Renata
authors.initials: R
authors.lastname: Krupa
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Majsterek
authors.forename: Jan
authors.initials: J
authors.lastname: Rykala
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kolacinska
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Morawiec
authors.forename: Jozef
authors.initials: J
authors.lastname: Drzewoski
authors.forename: Marek
authors.initials: M
authors.lastname: Zadrozny
authors.forename: Janusz
authors.initials: J
authors.lastname: Blasiak
mesh_terms: D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D051135:Rad51 Recombinase / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D024682:BRCA2 Protein; D004247:DNA; C495153:RAD51 protein, human; D051135:Rad51 Recombinase