title: On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease.
abstract: The human oxidised low-density lipoprotein receptor 1 (OLR1) gene is a functional candidate for atherosclerosis. An association of the OLR1 gene with acute myocardial infarction (AMI) or coronary artery disease (CAD) has recently been reported. In the present study a total of 677 Italian subjects, 327 CAD-free, 350 CAD, of which 190 with AMI and 160 AMI-free, was genotyped for the following four OLR1 single nucleotide polymorphisms: exon 4 K167N, IVS4 -73C>T, IVS4 -14A>G, and 3'UTR 188 C>T. No statistically significant difference was observed in allele or genotype distribution of the exon 4, intron 4, or 3'UTR SNPs in CAD patients compared to CAD-free subjects, or within CAD, in AMI patients compared to AMI-free patients. A correlation was found between the K167N G/G genotype and the increased number of obstructed vessels. Even if the OLR1 genotype frequency distribution data in CAD or AMI subjects here reported do not fully confirm the positive results of some other association studies, an association with a marker of CAD severity was observed.
authors.affiliation: Department of Mother and Child and of Biology-Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy. elisabetta.trabetti@univr.it
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Trabetti
authors.forename: Michele
authors.initials: M
authors.lastname: Biscuola
authors.forename: Ugo
authors.initials: U
authors.lastname: Cavallari
authors.forename: Giovanni
authors.initials: G
authors.lastname: Malerba
authors.forename: Domenico
authors.initials: D
authors.lastname: Girelli
authors.forename: Oliviero
authors.initials: O
authors.lastname: Olivieri
authors.forename: Nicola
authors.initials: N
authors.lastname: Martinelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Corrocher
authors.forename: Pier Franco
authors.initials: PF
authors.lastname: Pignatti
mesh_terms: D020413:3' Untranslated Regions; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy; D009203:Myocardial Infarction / Q000235:genetics*; D010084:Oxidation-Reduction; D020641:Polymorphism, Single Nucleotide; D051127:Scavenger Receptors, Class E / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E