Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study.
OBJECTIVE
Stem cell therapy may be useful in chronic myocardial infarction (MI); this is conceivable, but not yet demonstrated in humans.


BACKGROUND
After acute MI, bone marrow-derived cells improve cardiac function.


METHODS
We treated 18 consecutive patients with chronic MI (5 months to 8.5 years old) by the intracoronary transplantation of autologous bone marrow mononuclear cells and compared them with a representative control group without cell therapy.


RESULTS
After three months, in the transplantation group, infarct size was reduced by 30% and global left ventricular ejection fraction (+15%) and infarction wall movement velocity (+57%) increased significantly, whereas in the control group no significant changes were observed in infarct size, left ventricular ejection fraction, or wall movement velocity of infarcted area. Percutaneous transluminal coronary angioplasty alone had no effect on left ventricular function. After bone marrow cell transplantation, there was an improvement of maximum oxygen uptake (VO2max, +11%) and of regional 18F-fluor-desoxy-glucose uptake into infarct tissue (+15%).


CONCLUSIONS
These results demonstrate that functional and metabolic regeneration of infarcted and chronically avital tissue can be realized in humans by bone marrow mononuclear cell transplantation.
Strauer
Bodo E
BE
Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University, Düsseldorf, Germany. strauer@med.uni-duesseldorf.de
Brehm
Michael
M
Zeus
Tobias
T
Bartsch
Thomas
T
Schannwell
Christina
C
Antke
Christine
C
Sorg
Rüdiger V
RV
Kögler
Gesine
G
Wernet
Peter
P
Müller
Hans-Wilhelm
HW
Köstering
Matthias
M
D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000601:surgery*; D003331:Coronary Vessels; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D009206:Myocardium; D012038:Regeneration