title: Synthesis of novel piperidinyl linker based energy transfer terminators and their potential use in DNA sequencing.
abstract: Synthesis of novel piperidinyl linker based ET cassettes and terminators is described These novel terminators are evaluated in the DNA sequencing experiments using thermostable DNA polymerase.
authors.affiliation: G.E. Healthcare, 800 Centennial Ave., Piscataway, NJ 08855, USA. sudhakar.takellapati@ge.com
authors.forename: T Sudhakar
authors.initials: TS
authors.lastname: Rao
authors.forename: Satyam
authors.initials: S
authors.lastname: Nampalli
authors.forename: Weihong
authors.initials: W
authors.lastname: Zhang
authors.forename: Haiguang
authors.initials: H
authors.lastname: Xiao
authors.forename: Shiv
authors.initials: S
authors.lastname: Kumar
mesh_terms: D004247:DNA / Q000737:chemistry; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry*; D004735:Energy Transfer; D005456:Fluorescent Dyes / Q000494:pharmacology; D006358:Hot Temperature; D007202:Indicators and Reagents / Q000494:pharmacology; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D010880:Piperidines / Q000737:chemistry*; D017422:Sequence Analysis, DNA / Q000295:instrumentation* / Q000379:methods; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D010880:Piperidines; C032727:piperidine; D004247:DNA; D004259:DNA-Directed DNA Polymerase