title: A semi-symmetric two-locus model.
abstract: The two-locus symmetric viability model characterized by its invariance with respect to the exchange of alleles at each locus, is a well-studied model of classical two-locus theory. The symmetric model introduced by Lewontin and Kojima is among the few multi-locus models with epistatic interactions between loci for which a polymorphism with linkage equilibrium can be stable and this happens when recombination is sufficiently large. We show that an analogous property holds true for a different model, in which symmetry need exist at only one locus. The properties of this new semi-symmetric model are compared with those of the classical symmetric model. For tight linkage, two classes of polymorphisms are possible, depending on the magnitude of additive epistasis. The recombination rate above which linkage equilibrium becomes stable is derived analytically. As in the symmetric model, intervals of recombination in which no polymorphism is stable are possible, and stable polymorphisms can coexist with stable fixations.
authors.affiliation: Department of Biological Sciences, Stanford University, CA 94305, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Puniyani
authors.forename: Marcus W
authors.initials: MW
authors.lastname: Feldman
mesh_terms: D000483:Alleles; D004843:Epistasis, Genetic; D005787:Gene Frequency; D005828:Genetics, Population / Q000706:statistics & numerical data*; D006801:Humans; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D014481:United States