The efficacy of an oral treatment with paromomycin against an experimental infection with Giardia in calves.
A controlled and blinded study was conducted to evaluate the efficacy and safety of a treatment with paromomycin sulphate against an experimental Giardia infection in calves. Animals were infected with 10(5)Giardia cysts of cattle origin and were either treated 11 days later with 25, 50 or 75 mg paromomycin/(kg body weight per day) during 5 consecutive days or not treated (control group). Efficacy was evaluated based on reduction in cyst excretion. Furthermore weight gain and diarrhea scores were monitored. In the group treated with 75 mg/kg per day there was a 100% reduction in cyst excretion until 9 days after the start of the treatment (D9) and a very high reduction (> or =98%) until D13. There was a high reduction (> or =93%) until D9 and D13 in the groups treated with 25 and 50 mg/kg, respectively. The cumulative cyst excretion on D13 was significantly (P<0.05) lower in the groups treated with 75 and 50 mg/kg compared to the control group. Although there was a trend towards higher weight gain and less diarrhea in the treated groups, differences between groups were not significant. No adverse reactions to the paromomycin treatment were recorded. Furthermore, the need for reliable parameters for evaluation of treatments against protozoal infections is emphasised.
Geurden
T
T
Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. thomas.geurden@ugent.be
Claerebout
E
E
Dursin
L
L
Deflandre
A
A
Bernay
F
F
Kaltsatos
V
V
Vercruysse
J
J
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003967:Diarrhea / Q000453:epidemiology / Q000469:parasitology / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D005872:Giardia / Q000187:drug effects*; D005873:Giardiasis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D010303:Paromomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D016896:Treatment Outcome; D015430:Weight Gain
D000981:Antiprotozoal Agents; D010303:Paromomycin