title: Effect of povidone-iodine liposome hydrogel on colonic anastomosis.
abstract: BACKGROUND
  To evaluate the effect of povidone-iodine liposome hydrogel on colonic anastomosis.
  
  
  METHODS
  70 Wistar-Albino male rats were randomly divided into seven groups. The left colon was transected and end-to-end anastomosis was performed. PVP-I liposome hydrogel was applied around the anastomoses in groups 2 and 5. Colonic bursting pressures and tissue hydroxyproline contents were measured on postoperative days 3 and 7.
  
  
  RESULTS
  PVP-I application did not cause any difference in the bursting pressures on postoperative day 3, but anastomotic strength was significantly increased by the use of PVP-I on postoperative day 7. The use of PVP-I liposome hydrogel had no effect on the level of perianastomotic hydroxyproline on postoperative day 3 but had positive effects on postoperativeday 7.
  
  
  CONCLUSIONS
  We concluded that the beneficial effects of PVP-I liposome hydrogel might be due to the combination of broad-spectrum antimicrobial activity of PVP-I with the drug delivery properties and moisturizing molecular film effects of the liposome hydrogel.
authors.affiliation: Ankara Training and Research Hospital, 4th General Surgery Department, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ustek
authors.forename: K
authors.initials: K
authors.lastname: Kismet
authors.forename: M A
authors.initials: MA
authors.lastname: Akkus
authors.forename: A H
authors.initials: AH
authors.lastname: Ozcan
authors.forename: A
authors.initials: A
authors.lastname: Aydogan
authors.forename: N
authors.initials: N
authors.lastname: Renda
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000601:surgery; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry / Q000494:pharmacology*; D006909:Hydroxyproline / Q000378:metabolism; D008081:Liposomes; D008297:Male; D011206:Povidone-Iodine / Q000737:chemistry / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013530:Surgical Wound Infection / Q000517:prevention & control; D014014:Tissue Adhesives / Q000737:chemistry / Q000494:pharmacology; D014945:Wound Healing
chemical_list: D000891:Anti-Infective Agents, Local; D008081:Liposomes; D014014:Tissue Adhesives; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011206:Povidone-Iodine; D006909:Hydroxyproline