title: Effects of high NaCl diet on arterial pressure in Sprague-Dawley rats with hepatic and sinoaortic denervation.
abstract: The Na(+) receptor that exists in the hepatoportal region plays an important role in postprandial natriuresis and the regulation of Na(+) balance during NaCl load. Thus it would be considered that a dysfunction of the hepatic Na(+) receptor might result in the elevation of arterial pressure under a condition of high NaCl diet. To elucidate this hypothesis, arterial pressure was continuously measured during three weeks of high NaCl diet (8% NaCl) in four groups of rats: (i) intact rats, (ii) rats with hepatic denervation (HD), (iii) rats with sinoaortic denervation (SAD), and (iv) rats with SAD+HD. During a 1-week normal NaCl diet period, there was no difference in arterial pressure among the four groups. A high NaCl diet had no influence on arterial pressure in intact or HD rats; however, it significantly increased by 11 +/- 3 mmHg in SAD rats. The addition of HD to SAD had no synergistic effect on arterial pressure; i.e., in SAD+HD rats, mean arterial pressure increased by 13 +/- 1 mmHg. In conclusion, sinoaortic baroreceptor, but not hepatic Na(+) receptor, has a significant role in the long-term regulation of arterial pressure on a high NaCl diet.
authors.affiliation: Department of Physiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan.
authors.forename: Shuang
authors.initials: S
authors.lastname: Gao
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Taro M
authors.initials: TM
authors.lastname: Gotoh
authors.forename: Hironobu
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D001011:Aorta / Q000294:innervation*; D001794:Blood Pressure / Q000187:drug effects*; D002346:Carotid Sinus / Q000294:innervation*; D003714:Denervation; D006339:Heart Rate / Q000187:drug effects; D008099:Liver / Q000294:innervation*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
chemical_list: D017673:Sodium Chloride, Dietary