[A study of the aggregation of human red blood cells induced by picric acid].
The effect of picric acid on the aggregation of human erythrocytes was studied. It was shown that the addition of picric acid to a suspension of washed erythrocytes leads to a decrease in pH of medium to 1.5-2 and the formation of echinocytes. Stirring the suspension of echinocytes at low pH values results in a strong aggregation of cells. Increasing the pH value to 7.4 leads to a desaggregation of echinocytes. It was found that picric acid does not induce the aggregation of cells fixed by glutaraldehyde. A substantial decrease in the aggegation of spheric erythrocytes obtained after heating the cells at 50 degrees C was observed.
Sheremet'ev
Iu A
IuA
Sheremet'eva
A V
AV
Lednev
A V
AV
D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004912:Erythrocytes / Q000737:chemistry* / Q000166:cytology; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010851:Picrates / Q000494:pharmacology*; D014475:Uncoupling Agents / Q000494:pharmacology*
D010851:Picrates; D014475:Uncoupling Agents; C005858:picric acid