title: Metastatic colon cancer from intrahepatic cholangiocarcinoma.
abstract: A 62-year-old man had been followed because of an elevated serum level of carcinoembryonic antigen without the detection of any cancer lesions. However, there was a sudden increase in the serum level of carcinoembryonic antigen, and abdominal imagings showed a hepatic tumor with peripheral intrahepatic bile duct dilatation, and a submucosal tumor at the sigmoid colon with intact mucosa. Histopathological findings showed that the hepatic tumor had perineural invasion, suggesting an intrahepatic cholangiocarcinoma, and that the colon tumor infiltrated the submucosa, while its mucosa was intact. Both tumors showed similar pathological features and were positive for cytokeratin 20 and 7. These findings suggested intrahepatic cholangiocarcinoma with metastatic sigmoid colon cancer.
authors.affiliation: Department of Surgery, Yodogawa Christian Hospital, 2-9-26 Awaji, Higashi Yodogawa-ku, Osaka 533-0032, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Wakahara
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Shizuo
authors.initials: S
authors.lastname: Kitamura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Watanabe
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tsujimura
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Toyokawa
authors.forename: Norihito
authors.initials: N
authors.lastname: Onishi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hamabe
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Mukai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Teramura
mesh_terms: D001650:Bile Duct Neoplasms / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D002272:Carcinoembryonic Antigen / Q000097:blood; D018281:Cholangiocarcinoma / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000556:secondary*
chemical_list: D002272:Carcinoembryonic Antigen; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins