ADAM33: a newly identified gene in the pathogenesis of asthma.
There is much to find out about this fascinating and complex molecule in relation to the development and progression of asthma. Added to it are three further new asthma/allergy genes identified by positional cloning: PDH Finger Protein II (PHF11) on chromosome 13q14, which encodes NY-REN-34 a protein first described in patients with renal cell carcinoma [67]; Dipeptidyl diptidase 10 (DDP10) on chromosome 2q14 [68]; and G protein-coupled receptor for asthma susceptibility (GPRA) on chromosome 7p [69]. For each of these genes, as is the case for ADAM33, determining their normal function(s) and how these become disordered in asthma is the future challenge.
Holgate
Stephen T
ST
Infection, Inflammation, and Repair Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire, SO16 6YD, UK. sth@soton.ac.uk
Davies
Donna E
DE
Powell
Rob M
RM
Holloway
John W
JW
D051722:ADAM Proteins / Q000235:genetics*; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D051722:ADAM Proteins; C450441:ADAM33 protein, human