Invasive chromoblastomycosis and sinusitis due to Phialophora verrucosa in a child from northern Africa.
We report on a severe, verrucous facial mycosis and sinusitis in a 12-year-old Libyan girl. Her disease started with verrucous, hyperkeratotic plaques and subcutaneous violet nodules of unknown origin on her face and upper extremities. Despite topical antimycotic therapy she needed in-hospital treatment because of severely progressive tumorous cutaneous and nasal lesions. Microscopic examination of scale samples taken from the upper extremities and the face revealed brown, thick-walled fungal elements. Under the assumption of a chromoblastomycosis, an oral treatment with itraconazole and fluorocytosin was initiated, with significant improvement of the lesions. The aetiological agent was identified as Phialophora verrucosa.
Hofmann
H
H
Choi
S-M
SM
Wilsmann-Theis
D
D
Horré
R
R
de Hoog
G S
GS
Bieber
T
T
D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002862:Chromoblastomycosis / Q000382:microbiology* / Q000473:pathology*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005145:Face / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008002:Libya; D010676:Phialophora / Q000166:cytology / Q000302:isolation & purification*; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012852:Sinusitis / Q000382:microbiology* / Q000473:pathology; D034941:Upper Extremity / Q000382:microbiology / Q000473:pathology
D000935:Antifungal Agents; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D017964:Itraconazole