Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p < or = 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p < or = 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).
Bocca
Beatrice
B
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy. b.bocca@iss.it
Forte
Giovanni
G
Petrucci
Francesco
F
Pino
Anna
A
Marchione
Francesca
F
Bomboi
Giuseppe
G
Senofonte
Oreste
O
Giubilei
Franco
F
Alimonti
Alessandro
A
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000209:etiology; D015415:Biomarkers; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000009:adverse effects / Q000097:blood*; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012825:Silicon / Q000097:blood; D013048:Specimen Handling
D015415:Biomarkers; D008054:Lipid Peroxides; D008670:Metals; D016877:Oxidants; D006861:Hydrogen Peroxide; D012825:Silicon