title: Sealing of the hepatic resection area using fibrin glue reduces significant amount of postoperative drain fluid.
abstract: OBJECTIVE
  To investigate whether the routine use of fibrin glue applied onto the hepatic resection area can diminish postoperative volume of bloody or biliary fluids drained via intraoperatively placed perihepatic tubes and can thus lower the complication rate.
  
  
  METHODS
  Two groups of consecutive patients with a comparable spectrum of recent hepatic resections were compared: (1) 13 patients who underwent application of fibrin glue immediately after resection of liver parenchyma; (2) 12 patients who did not. Volumes of postoperative drainage fluid were determined in 4-h intervals through 24 h indicating the intervention caused bloody and biliary segregation.
  
  
  RESULTS
  Through the first 8 h postoperatively, there was a tendency of higher amounts of fluids in patients with no additional application of fibrin glue while through the following intervals, a significant increase of drainage volumes was documented in comparison with the first two 4-h intervals, e.g., after 12 h, 149.6 mL +/-110 mL vs 63.2 mL +/-78 mL. Using fibrin glue, postoperative fluid amounts were significantly lower through the postoperative observation period of 24 h (851 mL +/-715 mL vs 315 mL +/-305 mL).
  
  
  CONCLUSIONS
  For hepatic resections, the use of fibrin glue appears to be advantageous in terms of a significant decrease of surgically associated segregation of blood or bile out of the resection area. This might result in a better outcome.
authors.affiliation: Department of Surgery, University Hospital, Leipziger Strasse 44, Magdeburg D-39120, Germany. frank.eder@medizin.uni-magdeburg.de
authors.forename: Frank
authors.initials: F
authors.lastname: Eder
authors.forename: Frank
authors.initials: F
authors.lastname: Meyer
authors.forename: Gerd
authors.initials: G
authors.lastname: Nestler
authors.forename: Zuhir
authors.initials: Z
authors.lastname: Halloul
authors.forename: Hans
authors.initials: H
authors.lastname: Lippert
mesh_terms: D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000502:physiology; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000379:methods; D004322:Drainage; D005260:Female; D015718:Fibrin Tissue Adhesive; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D014014:Tissue Adhesives
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives