Synthesis of 3'-deoxy-3'-C-hydroxymethyl analogues of tiazofurin and ribavirin.
On the basis of potent biological activity of 3'-branched-3'-deoxynucleoside analogues, novel ribavirin and tiazofurin derivatives with 3'-C-hydroxymethyl substituent were synthesized, starting from D-xylose.
Chun
Moon Woo
MW
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Kim
Myong Jung
MJ
Shin
Ji Hye
JH
Jeong
Lak Shin
LS
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D014994:Xylose / Q000737:chemistry
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D005663:Furans; D009705:Nucleosides; D012254:Ribavirin; D014994:Xylose; C033706:tiazofurin