[Prevention of contrast nephropathy; guidelines from the Department Nephrology of the University Medical Centre Groningen].
Contrast nephropathy' is commonly defined as an increase in serum creatinine concentration of more than 44 micromol/l or 25% of the reference value within 48 hours after administration of radiological contrast media. Risk factors are pre-existing renal dysfunction, diabetes mellitus, heart failure, paraproteinaemia, advanced age, use of nephrotoxic medication, intra-arterial use of contrast media and use of large volumes of contrast media. The only form of therapy possible is supportive care, such as renal function replacement therapy. Prevention of contrast nephropathy is of great importance. For patients with risk factors, the treatment of first choice is hydration with intravenous sodium chloride 0.9% combined with oral acetylcysteine given before and after the administration of contrast media.
Huisman
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IA
Universitair Medisch Centrum Groningen, Postbus 30.001, 9700 RB Groningen. i.a.huisman@int.umcg.nl
Stegeman
C A
CA
Gans
R O B
RO
Gansevoort
R T
RT
D003287:Contrast Media / Q000009:adverse effects*; D005919:Glomerular Filtration Rate; D006801:Humans; D009398:Nephrology / Q000592:standards*; D009426:Netherlands; D017410:Practice Guidelines as Topic; D015532:Rehydration Solutions / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000139:chemically induced* / Q000517:prevention & control*; D012955:Societies, Medical; D012965:Sodium Chloride / Q000627:therapeutic use
D003287:Contrast Media; D015532:Rehydration Solutions; D012965:Sodium Chloride